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        "event_title":"Utilizing Biocatalysis and Synthetic Chemistry to Access New Natural Products",
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        "combined_title":"Utilizing Biocatalysis and Synthetic Chemistry to Access New Natural Products: Elizabeth Parkinson (Purdue)",
        "event_subtitle":"Elizabeth Parkinson (Purdue)",
        "event_type":"Workshop \/ Seminar",
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        "description":"Natural products (NPs) are a bountiful source of bioactive molecules. Bioinformatics data suggest hundreds-of-thousands of novel NPs remain to be discovered.  Unfortunately, many NPs are not produced under standard laboratory conditions. We are developing methods to access NPs from cryptic biosynthetic gene clusters (BGCs) utilizing a combination of bioinformatics, synthetic chemistry, and biocatalysis. Specifically, we are focused in two areas: cyclic peptides and \u03b3-butyrolactone (GBL) hormones. For cyclic peptides, we recently developed SNaPP (Synthetic Natural Product Inspired Cyclic Peptides). SNaPP expedites bioactive molecule discovery by combining bioinformatics predictions of non-ribosomal peptide synthetases with chemical synthesis of the predicted natural products. SNaPP enabled us to discover several bioactive cyclic peptides. However, it also opened our eyes to the challenge of synthesizing small cyclic peptides. Using the results from SNaPP, we identified a PBP-like cyclase capable of performing challenging cyclizations, such as for tetrapeptides with a greatly expanded substrate scope that could have great utility as a biocatalyst. For GBLs, these molecules have previously been found to induce production of many bioactive NPs. Over half of Streptomyces strains are predicted to have GBL signaling pathways. Unfortunately, only a few GBLs and their cognate repressors are known because 1) GBLs are produced at very low quantities and 2) no rapid, efficient assays exist to identify them. We bioinformatically predicted previously uncharacterized GBL receptors that we predict bind to known GBLs or close derivatives. We have developed synthetic and biocatalytic methods to access GBLs and derivatives in fewer steps and improved stereoselectivies. Finally, we have developed GFP-based assays that allow rapid identification of active hormones. This information will allow us to further explore the addition of exogenous hormones as a method to induce production of cryptic biosynthetic gene clusters.",
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        "event_title":"Ziwet Lecture I: Lorentzian Polynomials, Matroids over Hyperfields, and Related Topics",
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        "combined_title":"Ziwet Lecture I: Lorentzian Polynomials, Matroids over Hyperfields, and Related Topics: June Huh (Princeton University)",
        "event_subtitle":"June Huh (Princeton University)",
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        "description":"Lorentzian polynomials serve as a bridge between continuous and discrete convex analysis, with tropical geometry providing the critical link. The tropical connection is used to produce Lorentzian polynomials from discrete convex functions, leading for example to a short proof of Mason's conjecture on the number of independent sets of a matroid. This lecture series will explore the intricate relationships among Grassmannians over hyperfields, dequantization processes, and the theory of Lorentzian polynomials. In ongoing collaborative work with Matt Baker, Mario Kummer, and Oliver Lorscheid, we extend the connection between Lorentzian polynomials and discrete convex functions to matroids over triangular hyperfields, as introduced by Viro. This extension deepens our understanding of the space of Lorentzian polynomials, revealing a complex interplay among analysis, combinatorics, and geometry.\r\n\r\nThe three lectures in this series are designed to be accessible to a broad audience and appropriate for a Department Colloquium.\r\n\r\nAmong his many honors, Prof. Huh is a recipient of the Fields Medal (2022), the MacArthur Fellowship (2022), and the New Horizons in Mathematics Prize (2019). He received his PhD in Mathematics from U-M in 2014.",
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        "event_title":"Administrative Fellowship Webinar",
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        "event_title":"Sanger Leadership Center Info Session",
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        "datetime_modified":"20240515T155253",
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        "event_title":"Wallenberg Medal and Lecture | Nnimmo Bassey, Environmental Leader, Architect, Poet",
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        "combined_title":"Wallenberg Medal and Lecture | Nnimmo Bassey, Environmental Leader, Architect, Poet",
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        "description":"Full details on the Wallenberg website: https:\/\/myumi.ch\/kZdE2\r\n\r\nNnimmo Bassey, executive director of the Health of Mother Earth Foundation and a global environmental activist, will receive the 2024 Wallenberg Medal from the University of Michigan on Tuesday, September 10th in Ann Arbor.\r\n\r\nNnimmo Bassey is an architect and director of the Nigeria-based ecological think-tank, Health of Mother Earth Foundation (HOMEF) and member of the steering committee of Oilwatch International, a network resisting the expansion of fossil fuel extraction in the Global South. He chaired Friends of the Earth International (2008-2012), was a co-recipient of the 2010 Right Livelihood Award, also known as the \u201cAlternative Nobel Prize,\u201d and received the Rafto Human Rights Prize in 2012. Bassey has received honorary doctorate degrees from University of York (UK) in 2019 and from York University (Canada) in 2023. Bassey\u2019s books include *To Cook a Continent: Destructive Extraction* and *The Climate Crisis in Africa and Oil Politics: Echoes of Ecological War*. His poetry collections include: *We Thought It Was Oil But It Was Blood* (1998), *I Will Not Dance to Your Beat* (2010), and *I See the Invisible* (2024). \r\n\r\n\u201cAs an architect, poet, writer, and human rights advocate, Nnimmo Bassey works to address root cause issues driving climate migration, environmental and social impacts of extractive production, and hunger in the Niger Delta. His commitment to socio-ecological justice connects large-scale issues of climate change, exploitation of natural resources, and political\/corporate intransigence to the lives of individuals in the Niger Delta and beyond,\u201d said Sioban Harlow, Professor Emerita of Epidemiology and Global Public Health and chair of the Wallenberg Medal Executive Committee. \u201cJust as Raoul Wallenberg trained as an architect at the University of Michigan before bringing his multifaceted skills to humanitarian work, Bassey\u2019s background as an architect undergirds his environmental leadership.\u201d\r\n\r\n______________________________\r\n\r\nThe Wallenberg Medal and Lecture honors the legacy of Raoul Wallenberg who graduated from U-M\u2019s College of Architecture in 1935 and saved the lives of tens of thousands of Hungarian Jews near the end of World War II. In 1944, at the request of Jewish organizations and the American War Refugee Board, the Swedish Foreign Ministry sent Wallenberg on a rescue mission to Budapest. Over the course of six months, Wallenberg issued thousands of protective passports and placed many thousands of Jews in safe houses throughout the besieged city. He confronted Hungarian and German forces to secure the release of Jews, whom he claimed were under Swedish protection, and saved more than 80,000 lives.\r\n\r\nAdministered by the University\u2019s Donia Human Rights Center, U-M awards the Wallenberg Medal to those who, through their actions and personal commitment, perpetuate Wallenberg\u2019s extraordinary accomplishments and human values, and demonstrate the capacity of the human spirit to stand up for the helpless, to defend the integrity of the powerless, and to speak out on behalf of the voiceless.\r\n\r\nThe Wallenberg Medal and Lecture ceremony is free and open to the public. Tickets are not required. Please direct any inquiries about the event and requests for event accommodations to wallenberglecture@umich.edu or 734-936-3973.",
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