{ "140029-21886500": { "datetime_modified":"20250929T154847", "datetime_start":"20251009T120000", "datetime_end":"20251009T130000", "has_end_time":1, "date_start":"2025-10-09", "date_end":"2025-10-09", "time_start":"12:00:00", "time_end":"13:00:00", "time_zone":"America\/Detroit", "event_title":"Tools and Technology Seminar by Michelle Kim", "occurrence_title":"", "combined_title":"Tools and Technology Seminar by Michelle Kim: \u201cDetermining the driving factors shaping genetic architecture of complex traits in recently admixed populations\u201d", "event_subtitle":"\u201cDetermining the driving factors shaping genetic architecture of complex traits in recently admixed populations\u201d", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Abstract\r\n\r\nUnderstanding the genetic basis of complex traits in admixed populations is challenging due to diverse genetic backgrounds, particularly for highly prevalent diseases. Misinterpreting admixture\u2019s impact can have significant consequences for biomedical research. This study employs advanced computational biology to investigate how admixture shapes the genetic architecture of complex traits and influences GWAS outcomes. Using the forward-in-time population genetic simulator SLiM, we model trait evolution under admixture by varying the relationship between causal variant effect sizes and selection coefficients while accounting for population size changes and migration across five admixture scenarios. \r\n\r\nOur findings reveal that GWAS power is influenced by genetic architecture and population demographic history. Traits with weak correlations between effect size and fitness (e.g., anthropometric traits) show higher GWAS power compared to traits with stronger correlations (e.g., genetic diseases). Populations with recent bottlenecks exhibit higher GWAS power, highlighting the role of rare variants. Surprisingly, fine- mapping ability remains consistent across traits. Empirical validation using data from diverse populations, including the All of Us database, supports our simulation predictions. For anthropometric traits like height, common variants exhibit moderate effects, while for traits like malignant neoplasms, rare variants show larger effects and common variants minimal effects. \r\n\r\nBy integrating population and complex trait genetics, this study provides insights into how population history shapes genetic architecture and heritability. Our findings improve understanding of genetic studies in diverse populations, enabling more accurate biomedical applications and personalized medicine strategies. \r\n\r\nAbout The Tools & Technology Seminar Series\r\n\r\nThe DCMB Tools and Technology Seminar Series is held in Palmer Commons, Room 2036, each Thursday at 12pm EST. Each seminar highlights a computational tool, technology, or methodology that is under development or in current use and is of special interest to DCMB and University researchers. Presenters are U-M researchers and students.\r\n\r\nThese seminars are live-streamed and recorded and made available for future viewing via the DCMB YouTube Channel.", "occurrence_notes":null, "guid":"140029-21886500@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/140029", "building_id":"1005047", "building_name":"Palmer Commons", "campus_maps_id":"188", "room":"2036", "location_name":"Palmer Commons", "has_livestream":0, "cost":"", "tags":["Basic Science","Bioinformatics","Biosciences","Information and Technology"], "website":"https:\/\/umich.zoom.us\/j\/94417089006", "sponsors":[ { "group_name":"Department of Computational Medicine and Bioinformatics DCMB", "group_id":"5384", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2025\/09\/event_140029_original-1.png", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_thumb\/media\/attachments\/2025\/09\/event_140029_original-1.png", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2025\/09\/event_140029_original-1.png", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_2x\/media\/attachments\/2025\/09\/event_140029_original-1.png", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2025\/09\/event_140029_original-1.png", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb\/media\/attachments\/2025\/09\/event_140029_original-1.png", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb_square\/media\/attachments\/2025\/09\/event_140029_original-1.png", "group_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large\/media\/attachments\/2025\/09\/event_140029_original-1.png", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large_lightbox\/media\/attachments\/2025\/09\/event_140029_original-1.png", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_crop\/media\/attachments\/2025\/09\/event_140029_original-1.png", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2025\/09\/event_140029_original-1.png", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2025\/09\/event_140029_original-1.png", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2025\/09\/event_140029_original-1.png", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_grid_2x\/media\/attachments\/2025\/09\/event_140029_original-1.png", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_large\/media\/attachments\/2025\/09\/event_140029_original-1.png", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_thumb\/media\/attachments\/2025\/09\/event_140029_original-1.png" }, "occurrence_count":1, "first_occurrence":21886500 } , "137707-21880605": { "datetime_modified":"20250910T133959", "datetime_start":"20251009T120000", "datetime_end":"20251009T150000", "has_end_time":1, "date_start":"2025-10-09", "date_end":"2025-10-09", "time_start":"12:00:00", "time_end":"15:00:00", "time_zone":"America\/Detroit", "event_title":"U-M Farm Stand", "occurrence_title":"", "combined_title":"U-M Farm Stand", "event_subtitle":"", "event_type":"Well-being", "event_type_id":"12", "description":"New location, same Farm Stand! Join the U-M Sustainable Food Program (SL Sustainability) and the Campus Farm (Matthaei Botanical Gardens) every Thursday from 12-3pm to get produce grown by students for students. While the Diag is under construction, the Farm Stand will park just west of the North University Building. As always, students get a 30% discount and revenue from the Farm Stand will support the Student Food Empowerment Fund, which offers grants to students and student organizations to pursue student-powered sustainable food projects on and off-campus.", "occurrence_notes":"Just West of NUB, facing Chemistry Building, adjacent to the CCTC", "guid":"137707-21880605@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/137707", "building_id":"1000188", "building_name":"1100 North University Building", "campus_maps_id":"678", "room":"", "location_name":"1100 North University Building", "has_livestream":0, "cost":"", "tags":["campus farm","food","Food Justice","Sustainability","Well-being"], "website":"http:\/\/instagram.com\/umfarmstand", "sponsors":[ { "group_name":"University of Michigan Sustainable Food Program (UMSFP)", "group_id":"3267", "website":"http:\/\/umsustainablefood" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2025\/08\/event_137707_original-2.png", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2025\/08\/event_137707_original-2.png", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2025\/08\/event_137707_original-2.png", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2025\/08\/event_137707_original-2.png", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2025\/08\/event_137707_original-2.png", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2025\/08\/event_137707_original-2.png", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2025\/08\/event_137707_original-2.png", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2025\/08\/event_137707_original-2.png", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2025\/08\/event_137707_original-2.png", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2025\/08\/event_137707_original-2.png", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2025\/08\/event_137707_original-2.png", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2025\/08\/event_137707_original-2.png", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2025\/08\/event_137707_original-2.png", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2025\/08\/event_137707_original-2.png", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2025\/08\/event_137707_original-2.png", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2025\/08\/event_137707_original-2.png" }, "occurrence_count":13, "first_occurrence":21880598 } , "138950-21884284": { "datetime_modified":"20260427T090939", "datetime_start":"20251009T120000", "datetime_end":"20251009T170000", "has_end_time":1, "date_start":"2025-10-09", "date_end":"2025-10-09", "time_start":"12:00:00", "time_end":"17:00:00", "time_zone":"America\/Detroit", "event_title":"Watcher of the Sky: Making and Remaking the Detroit Observatory", "occurrence_title":"", "combined_title":"Watcher of the Sky: Making and Remaking the Detroit Observatory", "event_subtitle":"", "event_type":"Exhibition", "event_type_id":"7", "description":"The Detroit Observatory was once a hub of astronomical discovery that put the University of Michigan on the map as a world-class research institution. A century later, it was an abandoned building with an uncertain future. From cornerstone to keystone, from the first director to the people who saved it from destruction, explore the life of a historic observatory 170 years in the making.\n\n\"Watcher of the Sky\" is being developed by student docents at the Detroit Observatory. Presented by the Judy and Stanley Frankel Detroit Observatory, part of the Bentley Historical Library.\n\n\"Watcher of the Sky\" is now on display at the Detroit Observatory (1398 Ann Street, Ann Arbor, 48109). View the exhibit during the Observatory's open hours:\nThursdays 12-5 pm\nFridays 12-11 pm\nSelected Saturdays 12-5 pm", "occurrence_notes":null, "guid":"138950-21884284@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/138950", "building_id":"1000198", "building_name":"Detroit Observatory", "campus_maps_id":"189", "room":"", "location_name":"Detroit Observatory", "has_livestream":0, "cost":"", "tags":["Astronomers","astronomy","bentley historical library","bentley library","Education","educational","Exhibition","free","history","Museum","museums","Science","U-m History","university history","university of michigan history"], "website":"https:\/\/detroitobservatory.umich.edu\/exhibit\/watcher-of-the-sky-making-and-remaking-the-detroit-observatory\/", "sponsors":[ { "group_name":"Judy and Stanley Frankel Detroit Observatory", "group_id":"5385", "website":"https:\/\/detroitobservatory.umich.edu\/" }, { "group_name":"Bentley Historical Library", "group_id":"2901", "website":"http:\/\/bentley.umich.edu" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2025\/09\/event_138950_original-1.jpg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2025\/09\/event_138950_original-1.jpg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2025\/09\/event_138950_original-1.jpg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2025\/09\/event_138950_original-1.jpg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2025\/09\/event_138950_original-1.jpg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2025\/09\/event_138950_original-1.jpg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2025\/09\/event_138950_original-1.jpg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2025\/09\/event_138950_original-1.jpg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2025\/09\/event_138950_original-1.jpg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2025\/09\/event_138950_original-1.jpg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2025\/09\/event_138950_original-1.jpg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2025\/09\/event_138950_original-1.jpg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2025\/09\/event_138950_original-1.jpg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2025\/09\/event_138950_original-1.jpg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2025\/09\/event_138950_original-1.jpg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2025\/09\/event_138950_original-1.jpg" }, "occurrence_count":96, "first_occurrence":21884281 } , "138640-21883517": { "datetime_modified":"20250904T121715", "datetime_start":"20251009T121500", "datetime_end":"20251009T124500", "has_end_time":1, "date_start":"2025-10-09", "date_end":"2025-10-09", "time_start":"12:15:00", "time_end":"12:45:00", "time_zone":"America\/Detroit", "event_title":"Division Street Pipes", "occurrence_title":"", "combined_title":"Division Street Pipes: Ben Sidoti, organ", "event_subtitle":"Ben Sidoti, organ", "event_type":"Performance", "event_type_id":"15", "description":"\nJoin us as undergraduate student Ben Sidoti performs a 30-minute organ recital.\n\nThe University of Michigan Organ Department presents Division Street Pipes - the organ recital series at St. Andrew\u2019s Episcopal Church that brought weekly joy to attendees during its first season earlier this year - returns and will continue through early December.\n\nDivision Street Pipes concerts take place on Thursdays at 12:15 pm. Each recital features talented students and faculty of the U-M Organ Department. These 30-minute performances are free and open to the public, and audience members are invited to enjoy their lunch while listening. The series is co-sponsored by the University of Michigan Organ Department and St. Andrew\u2019s Episcopal Church in an effort to bring organ music to local audiences while connecting U-M organ students with the wider community. Concerts offer attendees the opportunity to hear the versatility of the pipe organ beyond a worship setting. \n\nPerformances begin on September 11, 2025 at 12:15pm and will occur every Thursday until December 4 (with the exception of November 27, Thanksgiving). You can be sure that each week, you will be in for a thrilling musical experience.", "occurrence_notes":null, "guid":"138640-21883517@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/138640", "building_id":"null", "building_name":"Off Campus Location", "campus_maps_id":"1", "room":"", "location_name":"St. Andrew\u2019s Episcopal Church, 306 N. Division St, Ann Arbor, MI 48104", "has_livestream":0, "cost":"Free - no tickets required", "tags":["Free","Music"], "website":"", "sponsors":[ { "group_name":"School of Music, Theatre & Dance (SMTD)", "group_id":"155", "website":"http:\/\/smtd.umich.edu\/events" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2025\/09\/event_138640_original-1.jpg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2025\/09\/event_138640_original-1.jpg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2025\/09\/event_138640_original-1.jpg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2025\/09\/event_138640_original-1.jpg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2025\/09\/event_138640_original-1.jpg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2025\/09\/event_138640_original-1.jpg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2025\/09\/event_138640_original-1.jpg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2025\/09\/event_138640_original-1.jpg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2025\/09\/event_138640_original-1.jpg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2025\/09\/event_138640_original-1.jpg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2025\/09\/event_138640_original-1.jpg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2025\/09\/event_138640_original-1.jpg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2025\/09\/event_138640_original-1.jpg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2025\/09\/event_138640_original-1.jpg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2025\/09\/event_138640_original-1.jpg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2025\/09\/event_138640_original-1.jpg" }, "occurrence_count":1, "first_occurrence":21883517 } , "139879-21886270": { "datetime_modified":"20251024T123156", "datetime_start":"20251009T130000", "datetime_end":"20251009T150000", "has_end_time":1, "date_start":"2025-10-09", "date_end":"2025-10-09", "time_start":"13:00:00", "time_end":"15:00:00", "time_zone":"America\/Detroit", "event_title":"2025 Coffee Chats with Morgan Stanley Investment Banking at University of Michigan", "occurrence_title":"", "combined_title":"2025 Coffee Chats with Morgan Stanley Investment Banking at University of Michigan", "event_subtitle":"", "event_type":"Careers \/ Jobs", "event_type_id":"2", "description":"Join us on Thursday, October 9 at University of Michigan for coffee chats with Morgan Stanley\u2019s Investment Banking Division. These informational coffee chats are designed to provide sophomores interested in our immersive summerinternships with the support and tools they need on their career journey.During your coffee chats with the Investment Banking\u00a0team, you\u2019ll have the opportunity to:\nLearn more aboutthe application and selection process for our internship programs\nGain valuable career advice and mentorship\nPolish your resumeand rehearse for interviews\nAsk any questions you may have about Morgan Stanley, our teams, or the industry in general\n\u00a0As this event is invite only and space is limited, please register to attend using this link by 5:00pm on Friday, October 3. We will notify you once your participation is confirmed. If selected, you will receive additional details and instructions on how to sign up for a timeslot.Date: Thursday, October 9Time: 1:00pm-3:00pm; if selected for a coffee chat, you will sign up for a specific 20-minute timeslotLocation: in-person (exact location to be disclosed once registration is confirmed)\u00a0No matter your field of interest or background, if you are ready to excel and looking for an opportunity to work alongside the best and brightest, in an environment where youare supported and empowered, then we hope to meet you! If you have any questions, please reach out to kaitlyn.amaro@morganstanley.com.", "occurrence_notes":null, "guid":"139879-21886270@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/139879", "building_id":"", "building_name":"", "campus_maps_id":"", "room":"", "location_name":"Michigan Union, Anderson Room, 530 S State St, Ann Arbor, MI 48109, USA", "has_livestream":0, "cost":"", "tags":[], "website":"", "sponsors":[ { "group_name":"University Career Center UCC", "group_id":"1140", "website":"http:\/\/careercenter.umich.edu" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21886270 } , "139845-21886161": { "datetime_modified":"20251024T123149", "datetime_start":"20251009T130000", "datetime_end":"20251009T150000", "has_end_time":1, "date_start":"2025-10-09", "date_end":"2025-10-09", "time_start":"13:00:00", "time_end":"15:00:00", "time_zone":"America\/Detroit", "event_title":"2025 Coffee Chats with Morgan Stanley Wealth Management at Michigan", "occurrence_title":"", "combined_title":"2025 Coffee Chats with Morgan Stanley Wealth Management at Michigan", "event_subtitle":"", "event_type":"Careers \/ Jobs", "event_type_id":"2", "description":"Join us on Thursday, October 9th, 2025 at the University of Michigan\u00a0for coffee chats with Morgan Stanley\u2019s Wealth Management. These informational coffee chats are designed to provide sophomores interested in our immersive summer internships with the support and tools they need on their career journey.During your coffee chats with the Wealth Management team, you\u2019ll have the opportunity to:\nLearn more about the application and selection process for our internship programs\nGain valuable career advice and mentorship\nPolish your resume and rehearse for interviews\nAsk any questions you may have about Morgan Stanley, our teams, or the industry ingeneral\nPlease register on the Morgan Stanley Portal: 2025 Coffee Chats with Morgan Stanley Wealth Management at Michigan - Morgan Stanley CampusAs this event is invite only and space is limited, please register to attend by 11:55pm EST on Sunday, October 5th, 2025. We will notify you once your participation is confirmed. 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