Happening @ Michigan https://events.umich.edu/list/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. Thesis Defense: Single Particle Microscopic and Spectroscopic Chemical Analysis of Primary and Secondary Aerosols (November 30, 2017 12:30pm) https://events.umich.edu/event/46720 46720-10592238@events.umich.edu Event Begins: Thursday, November 30, 2017 12:30pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Amy Bondy (Advisor: Dr. Andrew Ault)

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Other Thu, 30 Nov 2017 18:15:29 -0500 2017-11-30T12:30:00-05:00 2017-11-30T13:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
EEB Thursday Seminar: Toward translational evolutionary biology using the lens of genomics (November 30, 2017 4:00pm) https://events.umich.edu/event/42931 42931-9685656@events.umich.edu Event Begins: Thursday, November 30, 2017 4:00pm
Location: Chemistry Dow Lab
Organized By: Ecology and Evolutionary Biology

The process by which bacterial populations evolve to adapt to new hosts is broadly important and still uncertain. We study two key parts of this process: the nature and trajectories of beneficial mutations, and the eco-evolutionary dynamics that emerge when bacteria form biofilm communities. Identifying and tracking the spread of beneficial mutations has been empowered by contemporary genomics, and has allowed us to find commonalities among beneficial mutations in many evolving bacterial systems. Our study of biofilms has been aided by a simple model enabling long-term evolution in a biofilm life cycle. Focusing on bacteria of the Burkholderia cepacia complex and Pseudomonas aeruginosa, we find this model surprisingly selects for mutations in genes that commonly mutate during chronic infections of the cystic fibrosis airway and in wounds. This system also selects for persistent genetic diversity that reflect adaptations to different biofilm niches. More recently, we have been studying more rapid evolution of bacteria exposed to stronger selection like antibiotics or specific host association, often in vivo. In these conditions, we find strongly parallel mutations that show functional details of the traits that underlie adaptation. Further, growing cases of strong parallelism raise the probability that evolution may be predictable and useful to solve problems in medicine like drug resistance. Last and most important, we have used the simplicity of our biofilm model to develop a curriculum in high school classes to allow introductory biology students to learn key concepts in evolution and heredity by doing an evolution experiment. Both this curriculum and clear examples of evolution-in-action during infections offer the promise of broader appreciation of the utility of evolutionary biology.

View YouTube video of seminar: https://youtu.be/l7JHJ5eZLfM

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Lecture / Discussion Wed, 14 Feb 2018 16:31:26 -0500 2017-11-30T16:00:00-05:00 2017-11-30T17:00:00-05:00 Chemistry Dow Lab Ecology and Evolutionary Biology Lecture / Discussion Vaughn research image
Synthesis, Structures, and Photophysical Properties of Long-Chain Oligogermanes (November 30, 2017 4:00pm) https://events.umich.edu/event/45521 45521-10200819@events.umich.edu Event Begins: Thursday, November 30, 2017 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

It is expected that catenated compounds of germanium might function as luminescent or optical materials once a sufficient number of germanium atoms are connected together in the chain. We have prepared and characterized the penta- and hexagermanes Pri3Ge(GePh2)nGePri3 (n = 3 or 4), where the hexagermane is the longest structurally characterized linear oligogermane reported to date. Initial studies indicated that these molecules were luminescent in solution, and we have now investigated its photophysical properties of Pri3Ge(GePh2)4GePri3 in the solid state. The hexagermane exhibits temperature dependent absorbance and emission spectra, where vibrational fine structure is observed below 240 K. In addition, a blue emission in the visible region is observed upon excitation at 300 nm at 80 K. The synthesis of the two oligogermanes Pri3Ge(GePh2)nGePri3 (n = 3 or 4) and the nature of its absorbance and emission properties will be discussed in conjunction with DFT investigations. The structure/property relationships of other oligogermanes, including the branched systems (Ph3Ge)3GeX (X = H, F, Cl, Br, I, Ph, or GePh3), will also be discussed.














Scott Weinert (Oklahoma State University)

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Other Thu, 30 Nov 2017 18:15:29 -0500 2017-11-30T16:00:00-05:00 2017-11-30T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: Applications of Sterically Protected Hydrogen Bond Donors in the Secondary Coordination Sphere (December 1, 2017 2:00pm) https://events.umich.edu/event/46721 46721-10592239@events.umich.edu Event Begins: Friday, December 1, 2017 2:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Eric Dahl (Advisor: Dr. Nathaniel Szymczak)

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Other Fri, 01 Dec 2017 18:15:31 -0500 2017-12-01T14:00:00-05:00 2017-12-01T15:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: Microfabricated Probes for Monitoring Brain Chemistry at High Spatial and Temporal Resolution (December 5, 2017 10:00am) https://events.umich.edu/event/46722 46722-10592240@events.umich.edu Event Begins: Tuesday, December 5, 2017 10:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Thitaphat (Non) Ngernsutivorakul (Advisor: Dr. Robert Kennedy)

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Other Tue, 05 Dec 2017 18:15:29 -0500 2017-12-05T10:00:00-05:00 2017-12-05T11:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Ion Mobility Spectrometry: Beyond Separation and Structural Characterization (December 5, 2017 4:00pm) https://events.umich.edu/event/41470 41470-9269833@events.umich.edu Event Begins: Tuesday, December 5, 2017 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

When exposed to a constant electric field, ions in the gas phase move at constant drift velocities; the proportionality constant between an ion’s velocity and the applied electric field is termed the ion mobility. Correspondingly, ion mobility spectrometry (IM) is a gas phase separation technique in which analyte ions (as small as atomic ions and up to charged aerosol particles) are separated temporally or spatially in an electric. Recent years have seen increased usage of IM in two specific applications. First, it is used as a pre-separation technique with mass spectrometry to better identify analytes in complex mixtures. Second, IM is used as a tool to characterize the structures of protein and multiprotein complex ions in the gas phase. In both of these applications, IM is used primarily as a structural characterization tool, and the chemical information obtained in measurement is limited to collision cross section inference (a parameter directly linked to ion mobility). This presentation will discuss novel applications of IM developed in our laboratory group, where measurements go beyond collision cross section determination. Specifically, in conjunction with mass spectrometry, we are developing techniques to examine ion-neutral complex formation in the gas phase (with applications in chemical warfare agent detection, fundamental studies of ion-induced nucleation, and measurement of the properties of atmospheric nanoclusters) and as a standalone technique we utilize IM to examine nanoparticle-protein conjugation. Also discussed will be the potential application of ion mobility-mass spectrometry in air pollution monitoring, using newly developed data inversion schemes to isolate atmospheric aerosol populations from one another.














Chris Hogan (University of Minnesota)

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Other Tue, 05 Dec 2017 18:15:29 -0500 2017-12-05T16:00:00-05:00 2017-12-05T05:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: Rational Design and Activation of Metal-Organic Frameworks Towards Targeted Structures and Porosity (December 6, 2017 1:00pm) https://events.umich.edu/event/46936 46936-10703010@events.umich.edu Event Begins: Wednesday, December 6, 2017 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Jialiu Ma (Advisor: Dr. Adam Matzger)

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Other Wed, 06 Dec 2017 18:15:36 -0500 2017-12-06T13:00:00-05:00 2017-12-06T14:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
EEB Thursday Seminar: The role of Beringia in high latitude faunal diversification (December 7, 2017 4:00pm) https://events.umich.edu/event/46828 46828-10647793@events.umich.edu Event Begins: Thursday, December 7, 2017 4:00pm
Location: Chemistry Dow Lab
Organized By: Ecology and Evolutionary Biology

The Beringian Coevolution Project (BCP), a field program underway in the high northern latitudes since 1999, focuses on building basic scientific infrastructure for integrated specimen-based studies on mammals and their associated parasites. BCP has contributed new insights across temporal and spatial scales into how ancient climate and environmental change have shaped faunas, emphasizing processes of assembly, persistence and diversification across the vast Beringian region. BCP collections also represent baseline records of biotic diversity from across the northern high latitudes at a time of accelerated environmental change. Because of the dual focus on hosts and parasites, the BCP record also provides a foundation for comparative analyses that can document the effects of dynamic change on the geographic distribution, transmission dynamics, and emergence of pathogens. Using specific examples from carnivores, shrews, lagomorphs, rodents and their associated parasites, I show how broad, integrated field collections provide permanent infrastructure to explore the effect of climate change on natural populations and inform policy regarding human impacts on these environments.

View YouTube video of seminar: https://youtu.be/wC72vyA14xY

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Lecture / Discussion Wed, 14 Feb 2018 16:32:55 -0500 2017-12-07T16:00:00-05:00 2017-12-07T17:00:00-05:00 Chemistry Dow Lab Ecology and Evolutionary Biology Lecture / Discussion Beringia map
Enabling Medicinal Chemistry with Synthesis and Technology (December 7, 2017 4:00pm) https://events.umich.edu/event/41361 41361-9170360@events.umich.edu Event Begins: Thursday, December 7, 2017 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

In the Beeler Research Group we take a multidisciplinary approach toward developing small molecule tools for human disease. This lecture will focus on new technologies and synthetic strategies that provide a foundation for our medicinal chemistry programs. It will highlight ongoing efforts to develop platforms that enable us to explore and leverage the biological activities of complex natural products. A common theme in our lab, and in this lecture, is the use of flow chemistry to enable critical reactions. Why flow chemistry? Reactions have been carried out in batch vessels for over two centuries and amazingly the tools chemists use have remained largely unchanged. As such, many of the challenges presented by batch reactions are still unsolved. Issues related to mass transfer, heat transfer, or photon penetration can be exceptionally challenging in batch reactors, but are often overcome in flow. Ultimately, I hope to demonstrate how flow chemistry provides us a tool for development of new and more efficient reactions that are robust, highly scalable, and provide access to complex and novel chemotypes.



Aaron Beeler (Boston University)

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Other Thu, 07 Dec 2017 18:15:35 -0500 2017-12-07T16:00:00-05:00 2017-12-07T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
POSTPONED to Jan. 26, 2018 : Time and Motivation (December 8, 2017 12:15pm) https://events.umich.edu/event/46562 46562-10547332@events.umich.edu Event Begins: Friday, December 8, 2017 12:15pm
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Our seminar speaker has been invited to the Nobel ceremony so we are postponing this seminar. New date: January 26, 2018
Host: Orie Shafer

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Workshop / Seminar Tue, 14 Nov 2017 17:26:32 -0500 2017-12-08T12:15:00-05:00 2017-12-08T13:15:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Chemistry Dow Lab
Thesis Defense: Pharmaceutical Hydrates: Prevalence, Properties, and Progess (December 8, 2017 3:00pm) https://events.umich.edu/event/46723 46723-10592241@events.umich.edu Event Begins: Friday, December 8, 2017 3:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Kortney M. Kersten (Advisor: Dr. Adam Matzger)

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Other Fri, 08 Dec 2017 18:15:32 -0500 2017-12-08T15:00:00-05:00 2017-12-08T16:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: Computational Chemistry Studies of Organometallic Energy Lanscapes (December 11, 2017 10:30am) https://events.umich.edu/event/46937 46937-10703011@events.umich.edu Event Begins: Monday, December 11, 2017 10:30am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Ian Pendleton (Advisor: Drs. Melanie Sanford and Paul Zimmerman)

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Other Mon, 11 Dec 2017 18:15:27 -0500 2017-12-11T10:30:00-05:00 2017-12-11T11:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: Derivation Methods for Improved Metabolome Analysis by LC-MS/MS (December 13, 2017 9:30am) https://events.umich.edu/event/47283 47283-10857855@events.umich.edu Event Begins: Wednesday, December 13, 2017 9:30am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Paige Malec (Advisor: Dr. Robert T. Kennedy)

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Other Wed, 13 Dec 2017 18:15:23 -0500 2017-12-13T09:30:00-05:00 2017-12-13T10:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: Investigation of Cytochrome P450 Enzymes as Biocatalysts for Multifunctional C-H Oxidation; and a Case Study of a Graduate/Undergraduate Laboratory Exchange Program (December 13, 2017 1:00pm) https://events.umich.edu/event/46724 46724-10592242@events.umich.edu Event Begins: Wednesday, December 13, 2017 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Jessica Stachowski (Advisor: Dr. John Montgomery)

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Other Wed, 13 Dec 2017 18:15:22 -0500 2017-12-13T13:00:00-05:00 2017-12-13T14:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: Structural Characterization of Ribonucleic Acids and their Complexes by Negative-ion Mode Mass Spectrometry (December 13, 2017 4:00pm) https://events.umich.edu/event/47284 47284-10857856@events.umich.edu Event Begins: Wednesday, December 13, 2017 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Kevin Ileka (Advisor: Dr. Kristina I. Håkansson)

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Other Wed, 13 Dec 2017 18:15:23 -0500 2017-12-13T16:00:00-05:00 2017-12-13T17:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
EEB Thursday Seminar: How to eat something bigger than your head - microbial community assembly at the micron scale (December 14, 2017 4:00pm) https://events.umich.edu/event/47318 47318-10866128@events.umich.edu Event Begins: Thursday, December 14, 2017 4:00pm
Location: Chemistry Dow Lab
Organized By: Ecology and Evolutionary Biology

In this talk I will present our work showing how ecological interactions control the assembly and function of microbial communities at micro-scales. Using model marine particles composed of a variety of biopolymers commonly found in the ocean, I will show how microbial interactions such as cross-feeding and social cheating lead to rapid successional community assembly on particles. By comparing successions on different biopolymer particles, I’ll show how the bow tie structure of metabolic networks can lead to highly reproducible, convergent community dynamics that are independent of the initial carbon source. Finally, I will argue that community composition, in particular the load of primary degraders to cross-feeders, plays a fundamental role in controlling community function, i.e. the rates of particle turnover in the environment.

View YouTube video of seminar: https://youtu.be/6cl0D2LPCmY

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Lecture / Discussion Wed, 14 Feb 2018 16:34:24 -0500 2017-12-14T16:00:00-05:00 2017-12-14T17:00:00-05:00 Chemistry Dow Lab Ecology and Evolutionary Biology Lecture / Discussion microbial community
Thesis Defense: Development of Biocatalytic Strategies for the Directed Oxidation of Small Molecule and Macrocyclic Substrates (December 15, 2017 10:00am) https://events.umich.edu/event/47285 47285-10857857@events.umich.edu Event Begins: Friday, December 15, 2017 10:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Michael M. Gilbert (Advisor: Dr. John Montgomery)

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Other Fri, 15 Dec 2017 18:15:23 -0500 2017-12-15T10:00:00-05:00 2017-12-15T11:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
No EEB Thursday Seminar today (January 4, 2018 4:10pm) https://events.umich.edu/event/47958 47958-11157188@events.umich.edu Event Begins: Thursday, January 4, 2018 4:10pm
Location: Chemistry Dow Lab
Organized By: Ecology and Evolutionary Biology

See you next week

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Workshop / Seminar Tue, 02 Jan 2018 11:41:11 -0500 2018-01-04T16:10:00-05:00 2018-01-04T17:00:00-05:00 Chemistry Dow Lab Ecology and Evolutionary Biology Workshop / Seminar Chemistry Dow Lab
EEB Thursday Seminar: Mutation, drift, and the origin of subcellular features (January 11, 2018 4:00pm) https://events.umich.edu/event/47360 47360-10880012@events.umich.edu Event Begins: Thursday, January 11, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Ecology and Evolutionary Biology

Abstract
Although natural selection may be the most powerful force in the biological world, it is not all powerful. As a consequence, many aspects of evolution of the molecular level can only be explained by the inability of natural selection to operate. This general principle explains a lot about the diversity of genome architectures across species, and also appears to extend to numerous higher-level features of cells: the evolution of the ~1000-fold range in mutation rates that exists among species; greatly elevated rates of transcription error; the divergence of the multimeric states of proteins; and the phylogenetic drift of gene-regulatory vocabulary.

An attempt will be made to describe how these biological observations can be explained at the theoretical level, in some cases using methods derived from statistical mechanics. A fundamental principle is that although natural selection relentlessly pushes traits to the highest possible level of refinement, the limits to perfection are dictated by the power of random genetic drift rather than by intrinsic molecular limitations on repair mechanisms or by selection for an optimum mutation rate. The implications of this drift-barrier hypothesis are that the population-genetic environment imposes a fundamental constraint on the paths that are open vs. closed for evolutionary exploration in various phylogenetic lineages, hence defining the patterns of adaptation seen at the molecular and cellular level. Additional examples may be drawn from recent observations on the bioenergetic costs of maintaining and expressing genes.

Light refreshments are served at 4 p.m.

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Lecture / Discussion Thu, 11 Jan 2018 13:18:06 -0500 2018-01-11T16:00:00-05:00 2018-01-11T17:00:00-05:00 Chemistry Dow Lab Ecology and Evolutionary Biology Lecture / Discussion DNA strands
Cell Cycle Regulation of Cell Invasive Behavior (January 12, 2018 12:15pm) https://events.umich.edu/event/47193 47193-10813710@events.umich.edu Event Begins: Friday, January 12, 2018 12:15pm
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Hosts: Laura Buttitta and Gyorgyi Csankovszki

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Workshop / Seminar Thu, 30 Nov 2017 17:14:31 -0500 2018-01-12T12:15:00-05:00 2018-01-12T13:15:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar microscopic image
MICDE Seminar (January 16, 2018 4:00pm) https://events.umich.edu/event/41547 41547-9336682@events.umich.edu Event Begins: Tuesday, January 16, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


Theresa Windus (Iowa State University)

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Other Tue, 16 Jan 2018 18:15:29 -0500 2018-01-16T16:00:00-05:00 2018-01-16T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Theresa Windus: The Challenges of Exascale from the View of a Molecular Chemist (January 16, 2018 4:00pm) https://events.umich.edu/event/47787 47787-11012554@events.umich.edu Event Begins: Tuesday, January 16, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Michigan Institute for Computational Discovery and Engineering

Theresa Windus is a professor of Chemistry at Iowa State University. She earned her Ph.D. from Iowa State University in 1993 and did post-doctoral research at Northwestern University. Theresa was also the Director of Computational Chemistry/Training at Ohio Supercomputer Center and the Computational Chemistry lead at the Wright Patterson Air Force Base Major Shared Resource Center. Most recently, she was the manager of the Molecular Science Software Group and the Visualization and User Services group in the Molecular Science Computing Facility in the Environmental Molecular Sciences Laboratory of Pacific Northwest National Laboratory.

This talk will focus on the challenges that computational chemistry faces in taking the equations that model the very small (molecules and the reactions they undergo) to efficient and scalable implementations on the very large computers of today and tomorrow.

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Workshop / Seminar Tue, 19 Dec 2017 10:48:47 -0500 2018-01-16T16:00:00-05:00 2018-01-16T17:00:00-05:00 Chemistry Dow Lab Michigan Institute for Computational Discovery and Engineering Workshop / Seminar Windus
EEB Thursday Seminar: Genome evolution in laboratory populations of yeast (January 18, 2018 4:00pm) https://events.umich.edu/event/47365 47365-10880014@events.umich.edu Event Begins: Thursday, January 18, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Ecology and Evolutionary Biology

In his 1989 book, Wonderful Life, Stephen Jay Gould proposed the following thought experiment: Rewind the tape of life and let evolution play out a second time. Does the replay produce anything like what we see today? In other words, is evolution reproducible, or do chance events (perhaps inconsequential at the time) cause evolutionary paths to diverge? Using experimental evolution we can perform Gould's thought experiment in the laboratory by evolving hundreds of replicate populations.

We evolved ~600 replicate populations of the budding yeast, Saccharomyces cerevisiae, for 1,000 generations in rich glucose medium. We used whole-genome whole-population sequencing to examine the dynamics of genome sequence. Combining experimental evolution and quantitative genetics, we quantify the fitness effects of all mutations in 11 lineages and we identify genetic interactions.

Our results show that patterns of genome sequence evolution are driven by a balance between chance effects, which increase stochastic variation in evolutionary outcomes, and the deterministic action of selection on individual mutations, which favors parallel evolutionary solutions in replicate populations.

View YouTube video of seminar: https://youtu.be/QkVqvtbDq3Q

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Lecture / Discussion Wed, 14 Feb 2018 16:38:15 -0500 2018-01-18T16:00:00-05:00 2018-01-18T17:00:00-05:00 Chemistry Dow Lab Ecology and Evolutionary Biology Lecture / Discussion GregLangimage
Nutrient Regulation of Signaling and Transcription by O-GlcNAcylation (January 19, 2018 12:15pm) https://events.umich.edu/event/47194 47194-10813711@events.umich.edu Event Begins: Friday, January 19, 2018 12:15pm
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Yanzhuang Wang

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Workshop / Seminar Wed, 10 Jan 2018 15:15:57 -0500 2018-01-19T12:15:00-05:00 2018-01-19T13:15:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar diagram of signaling pathway
EEB Special Seminar: What 1.25 million scientific papers tell us about global biases in the creation and diffusion of scientific knowledge (and what we can do about it) (January 24, 2018 4:00pm) https://events.umich.edu/event/49092 49092-11375474@events.umich.edu Event Begins: Wednesday, January 24, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Ecology and Evolutionary Biology

"What 1.25 million scientific papers tell us about global biases in the creation and diffusion of scientific knowledge (and what we can do about it)"

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Lecture / Discussion Wed, 24 Jan 2018 13:23:23 -0500 2018-01-24T16:00:00-05:00 2018-01-24T17:00:00-05:00 Chemistry Dow Lab Ecology and Evolutionary Biology Lecture / Discussion scientific papers
EEB Thursday Seminar: Ecological impacts of chemical cues in marine systems (January 25, 2018 4:00pm) https://events.umich.edu/event/47817 47817-11015156@events.umich.edu Event Begins: Thursday, January 25, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Ecology and Evolutionary Biology

Among the many pressures that marine organisms face, intense competition and predation have contributed to the evolution of chemical defenses and the ability to sense chemical cues. Chemical ecologists have long sought to understand the identities, functions, and consequences of these compounds in the marine environment. However, traditional approaches to connect naturally occurring chemical compounds with ecological outcomes have often been unsatisfactory, especially for cases in which chemical cues and signaling molecules are waterborne and unstable; yields are low or variable; multiple compounds act synergistically or additively; and behavioral assays are labor-intensive or consume considerable amounts of a scarce molecule. We have developed a metabolomics-based strategy to take advantage of the natural variation in production of chemical cues across different environmental conditions towards identifying ecologically important waterborne molecules and their effects on organism behavior and physiology. As expected, marine organisms respond to a diversity of chemical species in their watery worlds, exhibiting dramatic behavioral and physiological changes when exposed to predators and competitors.

View YouTube video of seminar: https://youtu.be/7JkJ9ehjpoU

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Lecture / Discussion Wed, 14 Feb 2018 16:39:14 -0500 2018-01-25T16:00:00-05:00 2018-01-25T17:00:00-05:00 Chemistry Dow Lab Ecology and Evolutionary Biology Lecture / Discussion lady on tank
Time and Motivation (January 26, 2018 12:15pm) https://events.umich.edu/event/47195 47195-10813712@events.umich.edu Event Begins: Friday, January 26, 2018 12:15pm
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Orie Shafer

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Workshop / Seminar Fri, 19 Jan 2018 10:30:31 -0500 2018-01-26T12:15:00-05:00 2018-01-26T13:15:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar sleeping woman, domenico fetti
EEB Thursday Seminar: Demographic and evolutionary consequences of new gene flow into small populations (February 1, 2018 4:00pm) https://events.umich.edu/event/47839 47839-11025471@events.umich.edu Event Begins: Thursday, February 1, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Ecology and Evolutionary Biology

Rapidly changing rates of gene flow pose urgent challenges for wild populations as well as exciting opportunities for ecological and evolutionary study. Predicting fitness effects of altered gene flow among contemporary populations is crucial because there is a large range of potential outcomes that can go so far as to determine the difference between extinction and persistence. I study wild and experimental populations of Trinidadian guppies as a model system for understanding the effects of new gene flow on adaptation, fitness, and demography. Previous work has documented genetic rescue, an increase in population growth caused by the introduction of new alleles, in wild populations. I will recap this work as well as discuss preliminary findings from experimental mesocosms that highlight the potential for gene flow to provide longterm benefits when populations are exposed to novel stress.

View YouTube video of seminar: https://youtu.be/-hj6XA9CCEw

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Lecture / Discussion Wed, 14 Feb 2018 16:40:18 -0500 2018-02-01T16:00:00-05:00 2018-02-01T17:00:00-05:00 Chemistry Dow Lab Ecology and Evolutionary Biology Lecture / Discussion fishes
Contrasting Regulatory DNA Variation and Flexible Transcription Factor Function (February 2, 2018 12:15pm) https://events.umich.edu/event/47196 47196-10813713@events.umich.edu Event Begins: Friday, February 2, 2018 12:15pm
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Andrzej Wierzbicki

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Workshop / Seminar Fri, 19 Jan 2018 10:39:37 -0500 2018-02-02T12:15:00-05:00 2018-02-02T13:15:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar plant, yeast, worm
Krimm Special Lectureship: "Glutamate transporter dynamics: how fast can it go?" (February 2, 2018 4:00pm) https://events.umich.edu/event/48478 48478-11241169@events.umich.edu Event Begins: Friday, February 2, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Glutamate transporters are responsible for the uptake of the neurotransmitter glutamate from the synaptic cleft into glial cells in a process driven by the energy of ionic gradients. Extensive studies on a bacterial homologue GltPh have shown that these transporters operate by a so-called elevator mechanism, where a distinct “transport” domain moves the substrate and coupled ions across the membrane. The dynamics of this process, as well as that of substrate and ion binding and release, determine the rate at which the transporter operates. We aim to understand the nature of the energetic barriers that determine the dynamics and function of these transporters.

The Krimm lectureship was endowed by the Krimm family, and named after Professor Emeritus of Biophysics, Samuel Krimm. We thank Dr. Krimm for his many contributions and years of service to the University and the Biophysics Department.

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Workshop / Seminar Fri, 26 Jan 2018 15:23:53 -0500 2018-02-02T16:00:00-05:00 2018-02-02T17:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Olga Boudker
Science for the People: Then and Now (February 2, 2018 6:30pm) https://events.umich.edu/event/49507 49507-11465095@events.umich.edu Event Begins: Friday, February 2, 2018 6:30pm
Location: Chemistry Dow Lab
Organized By: Science for the People

Organizers from the original and current Science for the People will discuss the history of the radical science movement, the consequences of apolitical science, and the challenges the revitalized Science for the People faces. The event consists of three 30-minute presentations by the speakers, followed by a question-and-answer session.

Speaker Bios:

Ben Allen is a biologist and activist in east Tennessee. He is an organizer for the revitalized Science for the People and was a member of the Science for the People Research Collective. He works as a contractor on computational biology projects related to energy and environment.

Dr. Sigrid Schmalzer is a professor in the History Department and an officer in the faculty union at the University of Massachusetts Amherst. Her publications include two books, The People's Peking Man: Popular Science and Human Identity in Twentieth-Century China (2008) and Red Revolution, Green Revolution: Scientific Farming in Socialist China (2016). She was also the lead organizer for the 2014 conference "Science for the People: The 1970s and Today,” and she is co-editor, with Alyssa Botelho and Daniel S. Chard, of the new primary source volume Science for the People: Documents from America’s Movement of Radical Scientists (2017).

Dr. John Vandermeer is the Asa Gray Distinguished University Professor of Ecology and Evolutionary Biology as well as the Arthur F. Thurnau Professor in LSA's Department of Ecology and Evolutionary Biology. He has been involved in research and teaching in food and agriculture related topics for the past 40 years. His research has concentrated on the ecology of the coffee agroecosystem in Mexico, elaborating the complex ecological structures involved in complicated dynamics of the pest control system there. He has authored 15 books, mainly concerned with agroecosystems and more than 200 publications in theoretical ecology, tropical ecology and agroecology. He is a founding member of the New World Agriculture and Ecology Group. He is currently a professor of ecology at the University of Michigan. ​

*************

This event kicks off Science for the People's weekend-long convention. During the convention, we will be making collective decisions about our organizational structure, ratifying our foundational principles and bylaws, and developing national projects, we plan to include time to get to know one another, to learn from each other, and to further our political self-education. The original Science for the People arose in 1969 out of the anti-war movement and lasted until 1989. With radical analysis and non-hierarchical governing structure, Science for the People tackled the militarization of scientific research, the corporate control of research agendas, the political implications of sociobiology and other scientific theories, the environmental consequences of energy policy, inequalities in health care, and many other issues.

Its members opposed racism, sexism, and classism in science and above all sought to mobilize people working in scientific fields to become active in agitating for science, technology, and medicine that would serve social needs rather than military and corporate interests. They organized in universities and communities, published a magazine offering sharp political analysis, and sought meaningful scientific exchange internationally in Vietnam, China, Cuba, Nicaragua, and other countries.

Some of the issues we face today have changed in important ways, but fundamental questions of power, ideology, and democracy in science remain.

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Lecture / Discussion Wed, 31 Jan 2018 22:06:22 -0500 2018-02-02T18:30:00-05:00 2018-02-02T20:30:00-05:00 Chemistry Dow Lab Science for the People Lecture / Discussion A flyer with the same text as the event details.
Development of New Technologies for Medicinal Chemistry (February 6, 2018 4:00pm) https://events.umich.edu/event/47033 47033-10774244@events.umich.edu Event Begins: Tuesday, February 6, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Drug discovery programs are largely driven by the tools and techniques available to the synthetic medicinal chemist. Advancing these tools is critical to continued effectiveness in discovering molecules well suited to testing biological hypotheses in the clinic. This talk will highlight two such initiatives: strategic development of new chemical methods and creation of a platform to better integrate high-throughput experimentation into daily work.










Joseph Tucker (Pfizer)

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Other Tue, 06 Feb 2018 18:15:32 -0500 2018-02-06T16:00:00-05:00 2018-02-06T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
EEB Thursday Seminar: Can the Fisher-Lande process account for birds of paradise and other sexual radiations (February 8, 2018 4:00pm) https://events.umich.edu/event/48512 48512-11243800@events.umich.edu Event Begins: Thursday, February 8, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Ecology and Evolutionary Biology

Models of the Fisher-Lande process (FLP) have been used successfully to explore many aspects of evolution by sexual selection. Despite this success, quantitative tests of these models using data from sexual radiations are rare. Consequently, we do not know whether realistic versions of the FLP can account for the extent and the rate of evolution of sexually-selected traits. To answer this question, we generalize the basic FLP model of sexual coevolution and compare predictions of that basic model with patterns observed in an iconic sexual radiation, birds-of-paradise. Our model tracks the coevolution of male and female traits (two in each sex) while relaxing some restrictive assumptions. Using computer simulations, we evaluate the behavior of the model and confirm that it is an Ornstein-Uhlenbeck (OU) process. We also assess the ability of the FLP to account for the quantitative aspects of ornament evolution in the genus Paradisaea using published measurements of display traits and a phylogeny of the genus. Finally, we use program OUwie to compare model fits to generic OU and Brownian motion processes and to estimate FLP parameters. We show that to explain the sexual radiation of the genus Paradisaea one must either invoke extremely weak stabilizing selection on female mating preferences or allow the preference optimum to undergo Brownian motion at a modest rate.

View YouTube video of seminar: https://youtu.be/wx6hIxCuAaY

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Lecture / Discussion Wed, 14 Feb 2018 16:43:35 -0500 2018-02-08T16:00:00-05:00 2018-02-08T17:00:00-05:00 Chemistry Dow Lab Ecology and Evolutionary Biology Lecture / Discussion birds on branch
HP1B - a Euchromatic HP1 Homolog with Links to Metabolism (February 9, 2018 12:15pm) https://events.umich.edu/event/47197 47197-10813714@events.umich.edu Event Begins: Friday, February 9, 2018 12:15pm
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Gyorgyi Csankovszki

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Workshop / Seminar Thu, 30 Nov 2017 17:28:00 -0500 2018-02-09T12:15:00-05:00 2018-02-09T13:15:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar fly
Seminar Title: "Evolution, Epistasis and Ensembles: Studies of Protein Evolution Through Sequence Space" (February 9, 2018 4:00pm) https://events.umich.edu/event/48005 48005-11167561@events.umich.edu Event Begins: Friday, February 9, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

In the Harms lab, we are interested in the interplay between the biophysical properties of proteins and their evolution. I will discuss two ongoing projects. In the first, we are investigating how the map between protein genotype and phenotype shapes evolutionary outcomes. We have uncovered extensive multi-way interactions between mutations, meaning that the effect of a given mutation depends strongly on the presence of two or more other mutations. The magnitudes of these interactions are small, but they have an out-size effect on the accessibility of evolutionary trajectories. We have further found that we can produce these multi-way interactions using a simple, statistical thermodynamic model of proteins. This work reveals that the effect of mutations will be different if they occur early or late in evolution, and that knowing the effects of a mutation early in a trajectory is insufficient to predict future evolution. In the second project, we are experimentally investigating the evolution of new peptide binding specificity in several members of the S100 protein family. These proteins bind to extremely diverse, short regions of target proteins. Despite this apparent lack of specificity, we find that the same peptide binding profile has been conserved for different protein family members for the last 300 million years, suggesting this profile has been maintained by natural selection. To understand the origins of the specificity of these proteins, we next constructed a predictive binding model using a high-throughput peptide interaction assays coupled to supervised machine learning. We find that these proteins discriminate peptides based largely on packing and shape criteria rather than specific polar contacts. Further, by repeating these analyses on reconstructed ancestral proteins, we were able to reveal that protein specificity increased on one lineage while decreasing along the other. This reveals that extremely “sloppy” low-specificity proteins exhibit evolutionary patterns similar to those of well-studied high-specificity proteins.

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Workshop / Seminar Tue, 16 Jan 2018 11:32:48 -0500 2018-02-09T16:00:00-05:00 2018-02-09T17:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Michael Harms
EEB Tuesday Lunch Seminar: Evolution of vision in butterflies: phenotypic plasticity, gene duplication, and sexual dimorphism (February 13, 2018 12:10pm) https://events.umich.edu/event/47267 47267-10855077@events.umich.edu Event Begins: Tuesday, February 13, 2018 12:10pm
Location: Chemistry Dow Lab
Organized By: Ecology and Evolutionary Biology

PLEASE NOTE ROOM CHANGE. Join us for our weekly brown bag lunch seminar.

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Workshop / Seminar Tue, 06 Feb 2018 08:59:56 -0500 2018-02-13T12:10:00-05:00 2018-02-13T13:00:00-05:00 Chemistry Dow Lab Ecology and Evolutionary Biology Workshop / Seminar butterfly on a flower
Perovskite – a Wonder for Photovoltaic & Optoelectronic Applications (February 14, 2018 4:00pm) https://events.umich.edu/event/41621 41621-9391284@events.umich.edu Event Begins: Wednesday, February 14, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

A new type of perovskite, a hybrid material with both organic and inorganic components, has appeared to be a wonder for its excellent optical absorption, long range charge-carrier diffusion and apparent tolerance to defects. In the last few years, it has been emerged as a primary candidate material for various photovoltaic, optoelectronic and photoelectronic applications. In just a few years, the power conversion efficiency (PCE) of the perovskite solar cells has been improved from 3.8% to >22%. Moreover, the solar cell fabrication processes based on the planar architecture have been particularly enthusiastic thanks to their low temperature fabrication and compatibility with a range of substrates. Comparing solution deposition and vacuum deposition, the vacuum processes for thermal co-deposition and sequential deposition of PbCl2 and CH3NH3I materials are recognized as efficient means to prepare perovskite film with good uniformity and high surface coverage.
A vacuum deposition process has been developed to fabricate high efficiency perovskite solar cells with high stability using alternating layer-by-layer vacuum deposition. The new deposition process allows us to relax the strict deposition monitoring and control measures, while realizing superior uniformity in film morphology, surface coverage and smoothness, together with crystalline phase purity. More importantly, we have developed a superior low temperature TiO2 coating and transferred the cell fabrication process onto lightweight flexible polymeric substrate. Our current status for the rigid thin film cell efficiency is 22% and that for the flexible device over 18.3%, both are the highest for their respective category. Meanwhile, the devices show very good stability over long term exposure in ambient with very low degradation. After a representative cell was exposed in ambient lab condition for a year, its final cell efficiency is as high as over 95% of its initial efficiency with its degradation accounts for only smaller than 5%. Further analysis on the stability of the perovskite solar cells will be discussed.
We have also developed a series of single-crystalline perovskites with superior stability and optoelectronic performance.

References:
[1] D. Yang, R. Yang, X. Ren, X. Zhu, Z. Yang, C. Li, S. Liu*, Advanced Materials, http://dx.doi.org/10.1002/adma.201600446.
[2] D. Yang, R. Yang, J. Zhang, Z. Yang, S. Liu, C. Li, Energy Environ. Sci. 2015, 8, 3208.
[3] D. Yang, Z. Yang, W. Qin, Y. Zhang, S. Liu, C. Li, J. Mater. Chem. A 2015, 3, 9401.














Shengzhong (Frank) Liu (Shaanxi Normal University and Dalian Institute of Chemical Physics)

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Other Wed, 14 Feb 2018 18:15:54 -0500 2018-02-14T16:00:00-05:00 2018-02-14T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
EEB Thursday Seminar: Plant variability and the ecology of plant-insect interactions (February 15, 2018 4:00pm) https://events.umich.edu/event/49125 49125-11375514@events.umich.edu Event Begins: Thursday, February 15, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Ecology and Evolutionary Biology

Organism grow and reproduce best under a specific set of biotic and abiotic conditions, yet a quick look outside reveals a world that is astoundingly variable. Organisms face massive biotic and abiotic variability and only rarely experience their optimal conditions. How all this variability influences population and community ecology is poorly understood. In this talk, I explore how plant trait diversity affects the performance and population dynamics of insect herbivores. First, I use a meta-analysis to show that variance in plant nutrient levels reduces insect herbivore performance, suggesting that plant diversity suppresses insects, while monocultures benefit insects. Second, I use a natural plant-herbivore system to show that average plant quality can be less important than variance in plant quality for insect population dynamics. Finally, I present preliminary results from a new experimental approach to studying the consequences of trait variability along specific trait axes.

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Lecture / Discussion Tue, 23 Jan 2018 10:09:25 -0500 2018-02-15T16:00:00-05:00 2018-02-15T17:00:00-05:00 Chemistry Dow Lab Ecology and Evolutionary Biology Lecture / Discussion wetzel lab
Elucidation of catalytic strategies of small nucleolytic ribozymes from combined experimental and theoretical approaches (February 15, 2018 4:00pm) https://events.umich.edu/event/48444 48444-11235883@events.umich.edu Event Begins: Thursday, February 15, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The catalytic strategies that RNA uses to catalyze reactions have been examined for 40 years. I will present our labs latest efforts to elucidate how small nucleoyotic ribozymes catalyze chemical reactions. I will describe both experimental and theoretical approaches that we have taken on, with an emphasis of the last few years.

















Phil Bevilacqua (Penn State University)

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Other Thu, 15 Feb 2018 18:15:54 -0500 2018-02-15T16:00:00-05:00 2018-02-15T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other ribosome mechanism
Evolution and Development of Butterfly Wing Patterns (February 16, 2018 12:15pm) https://events.umich.edu/event/47198 47198-10813715@events.umich.edu Event Begins: Friday, February 16, 2018 12:15pm
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Ken Cadigan

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Workshop / Seminar Tue, 30 Jan 2018 13:12:24 -0500 2018-02-16T12:15:00-05:00 2018-02-16T13:15:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar butterfly wing close-up
Recent Advances in Fluorine (Radio) chemistry (February 16, 2018 2:00pm) https://events.umich.edu/event/48624 48624-11264839@events.umich.edu Event Begins: Friday, February 16, 2018 2:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The success of Positron Emission Tomography (PET) and renewed interest in [18F]radiochemistry led to creative methods to incorporate 18F into molecules of increasing complexity. Despite these advances, clinically useful radiotracers lie within a narrow accessible space with [18F]fluoroalkanes and [18F]fluoroarenes at the forefront. Many potentially high value PET 18F-labeled tracers and drugs lie outside this radiochemical space, and the ability to test tracers not amenable to traditional or newly developed 18F-labeling intervention would be a major boost for PET imaging. A more diverse range of 18F-tags could immediately serve medicinal chemists by informing the selection of lead compounds much earlier in the drug discovery pipeline. This lecture will present our general approach to late stage 18F-fluorination and the recent contribution we have made to this field of research with the labeling of a range of 18F-tags for PET.




















Veronique Gouverneur (University of Oxford)

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Other Fri, 16 Feb 2018 18:15:55 -0500 2018-02-16T14:00:00-05:00 2018-02-16T15:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
A Recent Story from Pharmaceutical Process Chemistry (February 19, 2018 4:00pm) https://events.umich.edu/event/49202 49202-11389445@events.umich.edu Event Begins: Monday, February 19, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The development, technology transfer, and current Good Manufacturing Practices implementation of a synthetic route designed for continuous processing is discussed in the context of an active clinical candidate.


















Kevin Cole (Eli Lilly)

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Other Mon, 19 Feb 2018 18:15:47 -0500 2018-02-19T16:00:00-05:00 2018-02-19T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Quantifying oxygen’s role in promoting aggressive cancer phenotypes with a paper-based 3D culture platform (February 20, 2018 4:00pm) https://events.umich.edu/event/40780 40780-8750076@events.umich.edu Event Begins: Tuesday, February 20, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Oxygen is a master regulator of a number of cellular processes. In tissues, gradients of oxygen and nutrients extend radially from blood vessels. The gradients in these diffusion-dominated environments increase greatly when a blood vessel is occluded, or in the case of the tumors, when the rate of proliferation outpaces the rate of vascularization. The extent of hypoxia in tumors has been correlated with cancer aggressiveness, drug resistance, and invasiveness. Gradients of oxygen are also believed to direct cellular invasion from the solid tumor mass to neighboring healthy tissue.
Despite the pivotal role that oxygen plays in tumor biology, there are a limited number of in vitro assays able to quantify cellular morphology, gene- and protein-expression, or drug sensitivities in well-defined oxygen gradients. Due to the lack of experimental tools, many studies compare cellular differences at a single normoxic (21% O2) and hypoxic (~0.2% O2) condition. Monolayer cultures are also commonly used in these normoxia-hypoxia comparisons. These experiments provide a simplified view of oxygen-mediated regulation, overlooking the importance of gradients by exposing cells to a single oxygen and nutrient concentration. Evaluating a limited number of oxygen tensions has led to the inadequate interpretation that cellular responses to oxygen are a binary phenomenon, eliciting a particular hypoxic phenotype or not.
We are developing a 3D culture platform utilizing paper-based scaffolds to prepare tissue- or organ-like structures. We are able to engineer extracellular environments with specific oxygen or nutrient gradients, and to tease apart the nuanced responses of cells in gradients of different steepness and shape. In this talk, I will highlight the paper-based culture platform as well as other technologies we are developing to address three long-standing questions in tumor biology. First is the role that oxygen gradients play in directing cellular movement. We have recently shown that oxygen is a chemo-attractant in diffusion-dominated environments, and are exploring what additional extracellular conditions (e.g., gradient steepness, presence of overlapping nutrient gradients) promote this directed invasion. Second is the oxygen-mediated mechanisms through which hypoxic cells become drug resistant. In particular, we use invasion assays and tumor-like structures to evaluate the relationship between oxygen tension, active resistance (upregulation of drug efflux pumps), and passive resistance (altered metabolism or halted proliferation). Third is the relationship between hypoxia and hormone responsiveness in estrogen receptor alpha positive (ER+) breast cancers.


















Matthew Lockett (University of North Carolina)

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Other Tue, 20 Feb 2018 18:15:47 -0500 2018-02-20T16:00:00-05:00 2018-02-20T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
EEB Thursday Seminar: America's next top model: what do we really know about her? (February 22, 2018 4:00pm) https://events.umich.edu/event/49254 49254-11397836@events.umich.edu Event Begins: Thursday, February 22, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Ecology and Evolutionary Biology

View YouTube video of seminar: https://youtu.be/SpUxRwMiteA

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Lecture / Discussion Tue, 27 Mar 2018 16:03:24 -0400 2018-02-22T16:00:00-05:00 2018-02-22T17:00:00-05:00 Chemistry Dow Lab Ecology and Evolutionary Biology Lecture / Discussion Xenopus
Orai 1 from Microdomain to Microbiome (February 22, 2018 4:00pm) https://events.umich.edu/event/47200 47200-10813716@events.umich.edu Event Begins: Thursday, February 22, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Note that this seminar is not at the usual MCDB seminar time.
Host: Haoxing Xu

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Workshop / Seminar Wed, 14 Feb 2018 10:59:06 -0500 2018-02-22T16:00:00-05:00 2018-02-22T17:00:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Chemistry Dow Lab
Ti-Catalyzed Nitrene Transfer Reactions: Harnessing the Ti(II)/Ti(IV) Redox Couple for New Organic Methods (February 22, 2018 4:00pm) https://events.umich.edu/event/48788 48788-11308872@events.umich.edu Event Begins: Thursday, February 22, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Titanium is an ideal metal for green and sustainable catalysis—it is the 2nd most earth-abundant transition metal, and the byproducts of Ti reactions (TiO2) are nontoxic. However, a significant challenge of utilizing early transition metals for catalytic redox processes is that they typically do not undergo facile oxidation state changes because of the thermodynamic stability of their high oxidation states. We have recently discovered that Ti imidos (LnTi=NR) can catalyze oxidative nitrene transfer reactions from diazenes via a TiII/TiIV redox couple, and are using this new mode of reactivity to develop a large suite of practical synthetic methods. In this talk, our latest synthetic and mechanistic discoveries related to Ti nitrene transfer catalysis will be discussed, including new synthetic methods for the modular, selective construction of pyrroles via [2+2+1] cycloaddition of alkynes with Ti nitrenes and alkynes, as well as new methods for catalytic oxidative carboamination of other unsaturated organics by Ti nitrenes.
















Ian Tonks (University of Minnesota)

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Other Thu, 22 Feb 2018 18:15:50 -0500 2018-02-22T16:00:00-05:00 2018-02-22T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Free Practice LSAT (February 22, 2018 5:30pm) https://events.umich.edu/event/49946 49946-11608278@events.umich.edu Event Begins: Thursday, February 22, 2018 5:30pm
Location: Chemistry Dow Lab
Organized By: Newnan LSA Academic Advising Center

Participate in a proctored LSAT practice exam. Registration required: https://sessions.studentlife.umich.edu/track/event/session/6546

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Workshop / Seminar Fri, 16 Feb 2018 11:41:43 -0500 2018-02-22T17:30:00-05:00 2018-02-22T20:30:00-05:00 Chemistry Dow Lab Newnan LSA Academic Advising Center Workshop / Seminar Pre-Law Event Image
Thesis Defense: Probing the Chemical Stability and Adsorption Properties of Molecule|Metal Oxide Architectures under Conditions of Photoelectrochemical Water Oxidation (February 23, 2018 1:00pm) https://events.umich.edu/event/49920 49920-11577477@events.umich.edu Event Begins: Friday, February 23, 2018 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Samuel L. Esarey (Advisor: Bart M. Bartlett)

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Other Fri, 23 Feb 2018 18:15:47 -0500 2018-02-23T13:00:00-05:00 2018-02-23T14:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
"MOLECULAR DETAILS OF GLYCAN SCAVENGING AT THE BACTERIAL CELL SURFACE: THE BACTEROIDETES SUS-LIKE PARADIGM" (February 23, 2018 4:00pm) https://events.umich.edu/event/50247 50247-11690347@events.umich.edu Event Begins: Friday, February 23, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

The Bacteroidetes are a dominant Bacterial phylum in the mammalian gastrointestinal tract and have a greatly expanded capacity for complex carbohydrate utilization. Most of the glycosidic potential within the Bacteroidetes is packaged into discrete polysaccharide utilization loci (PULs) that each encode a series of enzymes and cell-surface proteins that coordinate with a cognate TonB-dependent transporter in order to bind, degrade and import carbohydrate nutrition. PUL-encoded carbohydrate processing systems are referred to as “Sus-like systems” after the starch utilization system first described in Bacteroides thetaiotaomicron. However, since the discovery of the Sus, similar systems have been found in the genomes of every gut associated Bactetoidetes, extending a Sus-like paradigm for glycan uptake within this Bacterial phylum. Our work over the past few years has described the protein structures of the surface glycan binding proteins (SGBPs) found within the Sus of B. thetaiotaomicron, as well other PUL-encoded Sus like systems that target different glycans. Here we describe our current work to determine how the SGBPs of various human gut Bacteroides species allow the cells to select and import specific glycans from the intestinal environment.

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Workshop / Seminar Mon, 19 Feb 2018 14:54:53 -0500 2018-02-23T16:00:00-05:00 2018-02-23T17:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Nicole Koropatkin
Reaction Development in the Amide Playground (March 5, 2018 4:00pm) https://events.umich.edu/event/48625 48625-11264840@events.umich.edu Event Begins: Monday, March 5, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

I will deliver 4 topics on the amide functionality;

1. Direct enolization chemistry of amide via designed asymmetric cooperative catalytic system. [JACS 2015, 137, 15929, etc.]

2. Utility of asymmetric amide-based ligand for asymmetric flow catalysis.
[ACIE 2013, 52, 6196, etc.]

3. Catalytic direct dehydrative amidation by a novel B3NO2 heterocyclic catalyst. [Nature Chem. doi:10.1038/nchem2708, etc.]

4. Twisting amide planarity: structural study and reactivity. [Chem. Sci. 2017, 8, 85, etc.]

These issues will be discussed with emphasis on synthetic utility and reaction mechanisms.








Naoya Kumagai (Institute of Microbial Chemistry, Tokyo)

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Other Mon, 05 Mar 2018 18:15:34 -0500 2018-03-05T16:00:00-05:00 2018-03-05T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Photoisomerization for the Synthesis of Enantioenriched Beta-Aryloxyesters and the Evolution of a Process Route to ABT-333 (March 6, 2018 4:00pm) https://events.umich.edu/event/47214 47214-10819237@events.umich.edu Event Begins: Tuesday, March 6, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Two project highlights from AbbVie Process Chemistry will be discussed.
















Elizabeth Swift (AbbVie)

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Other Tue, 06 Mar 2018 18:15:37 -0500 2018-03-06T16:00:00-05:00 2018-03-06T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Master’s Thesis Defense: Phillip Yang (March 7, 2018 8:00am) https://events.umich.edu/event/50548 50548-11796690@events.umich.edu Event Begins: Wednesday, March 7, 2018 8:00am
Location: Chemistry Dow Lab
Organized By: Biomedical Engineering

Osteoporosis is a degenerative bone disease that causes a significant decrease in bone density and quality. It affects 73 million people worldwide and is usually diagnosed at fracture. Under-treatment of the disease can lead to preventable fracture, falls, and death; whereas over-treatment can cause associated negative effects, such as atypical fracture.

The changes to the collagen nano- and micro-structure and the changes in mineral to matrix composition are not fully understood, and these changes are important to better understanding the biomechanics of bone.

Thus, the lumbar vertebrae (LV) 2 and 4 of cyno monkeys that were treated, osteoporotic, or healthy were studied. One group was submitted to Sham surgery, and the rest were ovariectomized (OVX). Two years post-surgery, the monkeys were either treated with Alendronate, a Cathepsin K inhibitor, Denosumab, or left untreated.

Atomic force microscopy (AFM) coupled to infrared (IR) spectroscopy was used for topographical imaging and chemical composition characterizations of the LV4. This data provides both structural and chemical data over a length scale that is applicable to the biomechanical properties of bone.

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Presentation Wed, 28 Feb 2018 18:41:02 -0500 2018-03-07T08:00:00-05:00 2018-03-07T09:00:00-05:00 Chemistry Dow Lab Biomedical Engineering Presentation Chemistry Dow Lab
Thesis Defense: Folate Binding Protein as a Therapeutic Natural Nanotechnology (March 7, 2018 10:00am) https://events.umich.edu/event/50001 50001-11613944@events.umich.edu Event Begins: Wednesday, March 7, 2018 10:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Rachel L. Wallace (Advisor: Dr. Mark Banaszak Holl)

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Other Wed, 07 Mar 2018 18:15:39 -0500 2018-03-07T10:00:00-05:00 2018-03-07T11:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: "Fatigue Failure Mechanism of Anterior Cruciate Ligament Fracture" (March 7, 2018 1:00pm) https://events.umich.edu/event/50455 50455-11771159@events.umich.edu Event Begins: Wednesday, March 7, 2018 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Junjie Chen (Advisor: Dr. Mark Banaszak Holl)

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Other Wed, 07 Mar 2018 18:15:39 -0500 2018-03-07T13:00:00-05:00 2018-03-07T14:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
EEB Thursday Seminar: Seeing the forest through the leaves: reconstructing ancient forest ecosystems in Wyoming and Ethiopia (March 8, 2018 4:00pm) https://events.umich.edu/event/49165 49165-11383832@events.umich.edu Event Begins: Thursday, March 8, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Ecology and Evolutionary Biology

Fossil plants are most often preserved as isolated leaves, not entire organisms, making it especially challenging to reconstruct 3-dimensional ecosystems from fossil remains. New proxies involving leaf venation, micromorphological structure, and carbon isotopes are currently being developed to reconstruct vegetation structure from isolated leaf fossils. Fossil leaves also record insect feeding traces, direct evidence of two levels in a fossil food web, and changes in insect herbivory can be related to environmental changes. Case studies using fossil leaves from the western US and Ethiopia will examine changes in forest ecosystems during times of climate change, including the Paleocene-Eocene Thermal Maximum, a geologically abrupt perturbation to the carbon cycle and global climate that is the best geologic analog for modern-day global warming.

View YouTube video of seminar: https://youtu.be/Tc3Q6y3ytQw

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Lecture / Discussion Tue, 27 Mar 2018 16:04:44 -0400 2018-03-08T16:00:00-05:00 2018-03-08T17:00:00-05:00 Chemistry Dow Lab Ecology and Evolutionary Biology Lecture / Discussion leaf fossils
Mighty Chemistry of Bacterial Small Molecules (March 8, 2018 4:00pm) https://events.umich.edu/event/47034 47034-10774245@events.umich.edu Event Begins: Thursday, March 8, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Bacteria live a rich metabolic life. They synthesize a remarkable array of small molecules that exhibit intriguing chemical structures and potent biological activities. As a result, these molecules have found wide use as life-saving medicine and tools to study biology. This talk will discuss our work on deciphering the chemistry in the mode of action and biosynthesis of antimicrobial small molecules. A new mode of action has been identified for a broad-spectrum antimicrobial compound called holomycin produced by a soil bacterium. The action of holomycin involves chelating metal ions in the target bacterial cell and inhibiting the activity of metalloenzymes. This mechanism may be explored to control multidrug-resistant bacterial infections. The biosynthesis of antimicrobial nonproteinogenic amino acids will also be discussed.













Bo Li (University of North Carolina - Chapel Hill)

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Other Thu, 08 Mar 2018 18:15:36 -0500 2018-03-08T16:00:00-05:00 2018-03-08T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: "A quaternary Lewis base reductive aldol towards isopalhinine A" (March 9, 2018 9:00am) https://events.umich.edu/event/50505 50505-11785336@events.umich.edu Event Begins: Friday, March 9, 2018 9:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Yvonne DePorre (Advisor: Corinna Schindler)

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Other Fri, 09 Mar 2018 18:15:38 -0500 2018-03-09T09:00:00-05:00 2018-03-09T10:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
The Sodium/Iodide Symporter (NIS): From Patient to Molecule and Back (March 9, 2018 12:15pm) https://events.umich.edu/event/47201 47201-10813717@events.umich.edu Event Begins: Friday, March 9, 2018 12:15pm
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Randy Stockbridge

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Workshop / Seminar Fri, 23 Feb 2018 11:54:45 -0500 2018-03-09T12:15:00-05:00 2018-03-09T13:15:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar cell diagram and molecule diagram
CANCELED -Seminar Title: "Folded Viral RNAs that Sense and Manipulate the Host Cell Machinery: Windows into RNA Structure-Based Regulation" (March 9, 2018 4:00pm) https://events.umich.edu/event/48480 48480-11241171@events.umich.edu Event Begins: Friday, March 9, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

RNA is perhaps the most functionally diverse biological macromolecule, due in large part to its ability to adopt a wide range of conformationally dynamic structures. The Kieft Lab is interested in understanding how RNA can adopt diverse three-dimensional folds, how those folds give rise to its many biological roles, and how conformational changes confer RNA’s ability to regulate so many processes. We are particularly interested in viral RNAs, which are fine-tuned by evolution to elegantly and powerfully interact with and manipulate the cellular machinery of the host cell; these viral RNAs provide a “window” into the greater RNA world. In this presentation, I will present some of our recent findings in regard to a viral RNA that adopts an unexpected tertiary structure. This RNA element undergoes programmed conformational changes that are triggered by its interactions with the host cell machinery and this is responsible for its unique function. This RNA may be a paradigm for novel modes of regulation linked to dynamic RNA conformational changes.

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Workshop / Seminar Thu, 08 Mar 2018 10:59:14 -0500 2018-03-09T16:00:00-05:00 2018-03-09T17:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Jeffrey Kieft
Thesis Defense: "Remote C-H Functionalization of Aliphatic Amines" (March 12, 2018 1:00pm) https://events.umich.edu/event/50456 50456-11771160@events.umich.edu Event Begins: Monday, March 12, 2018 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Melissa Lee (Advisor: Dr. Melanie Sanford)

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Other Mon, 12 Mar 2018 18:15:36 -0400 2018-03-12T13:00:00-04:00 2018-03-12T14:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
ELI Winter Workshop Series: Finding Your Voice -- Confidence and Clarity for Public Speaking (March 13, 2018 12:00pm) https://events.umich.edu/event/48482 48482-11241173@events.umich.edu Event Begins: Tuesday, March 13, 2018 12:00pm
Location: Chemistry Dow Lab
Organized By: English Language Institute

When you give a presentation, does your voice express confidence? Is it loud enough? Do your listeners easily understand you? Is your audience engaged? Come to this workshop to explore voice and pronunciation techniques to make your presentations shine. You will receive hands-on practice presenting for one minute on a topic of your choice such as a self-introduction, an overview of your broad area of research, a new development in your field, or a quick story of something interesting you’ve experienced. Bring a script or outline with you to work on together.

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Workshop / Seminar Mon, 12 Mar 2018 10:45:32 -0400 2018-03-13T12:00:00-04:00 2018-03-13T14:00:00-04:00 Chemistry Dow Lab English Language Institute Workshop / Seminar ELI Winter Workshop Series
Thesis Defense: A New Decarboxylase: A Mechanistic Characterization of PrFMN Decarboxylase FDC1 (March 14, 2018 1:00pm) https://events.umich.edu/event/50711 50711-11853301@events.umich.edu Event Begins: Wednesday, March 14, 2018 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Kyle Ferguson (Advisor: Dr. E. Neil G. Marsh)

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Other Wed, 14 Mar 2018 18:15:38 -0400 2018-03-14T13:00:00-04:00 2018-03-14T14:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: "Insights into Crystalline and Material Solids from Advances in Magic Angle Spinning NMR" (March 14, 2018 2:30pm) https://events.umich.edu/event/50457 50457-11771161@events.umich.edu Event Begins: Wednesday, March 14, 2018 2:30pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Joshua Damron (Advisor: Dr. Ayyalusamy Ramamoorthy)

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Other Wed, 14 Mar 2018 18:15:38 -0400 2018-03-14T14:30:00-04:00 2018-03-14T15:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Elastomeric Surfaces for the Rational Synthesis, Assembly, and Fabrication of Adaptive, Functional Materials (March 14, 2018 4:00pm) https://events.umich.edu/event/49885 49885-11566241@events.umich.edu Event Begins: Wednesday, March 14, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

We are investigating new synthetic strategies for the fabrication of adaptive, hybrid structures comprised of combinations of soft materials (e.g., polymers) and hard materials (e.g., inorganic crystals) with functional (optical, mechanical, magnetic, etc.) characteristics. Central to these efforts are elastomeric surfaces with heterogeneous chemical and physical properties that can be reversibly reconfigured using simple, macro-scale processes such as mechanical deformations—we refer to these mechanically tunable surfaces as 2D “assembly substrates.” Specifically, we focus on systems fabricated from elastomeric polymers, such as silicones, which provide a diversity of chemical and mechanical properties. In this talk I will highlight our recent findings related to the synthesis and application of mechanically tunable surfaces, which include the assembly of solids (e.g., inorganic films with switchable reflectance and microparticles with optical/catalytic activity) and the manipulation of liquids (e.g., picoliter-volume droplets of aqueous solutions and prepolymer droplets). The unique properties of these surfaces and the diverse capabilities they provide will enable new methods and structures for the micro-/nanoscale manipulation, organization, and assembly of liquids/solids, and provide new techniques for the fabrication of hybrid structures applicable to emergent technologies, for example, soft sensors, optics, and electronics, soft actuators for soft machines/robotics, and smart surfaces with adaptive adhesion. Furthermore, the ability of the strategies we demonstrate to operate simultaneously on large numbers of micro-/nanoscale functional components using macroscale processing (e.g., tensile deformations) presents unique advantages in the scalable, advanced manufacturing of functional structures.














Stephen Morin (University of Nebraska-Lincoln)

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Other Wed, 14 Mar 2018 18:15:38 -0400 2018-03-14T16:00:00-04:00 2018-03-14T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
A mechanistic approach to metal-organic framework synthesis and applications (March 15, 2018 4:00pm) https://events.umich.edu/event/50281 50281-11701586@events.umich.edu Event Begins: Thursday, March 15, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

As metal-organic frameworks continue to gain prominence and more targeted syntheses become the norm, mechanistic elaboration of the synthesis of these materials, specifically the formation of the secondary building unit (SBU) is paramount. Through a combination of solvothermal synthesis, solid-state to solid-state transformations, and in situ Raman spectroscopy, proposed mechanisms of formation (along with their synthetic consequences) of select indium-derived SBUs will be presented. Additionally, the non-covalent interactions involved in solution-phase sorptive extraction of pharmaceuticals and heavy metals (Pb and Cs) by select MOFs will be examined.










Doug Genna (Youngstown State University)

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Other Thu, 15 Mar 2018 18:15:38 -0400 2018-03-15T16:00:00-04:00 2018-03-15T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
EEB Thursday Seminar: The role of a biology education gateway in promoting faculty teaching scholarship and increasing project impact (March 15, 2018 4:00pm) https://events.umich.edu/event/49172 49172-11386605@events.umich.edu Event Begins: Thursday, March 15, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Ecology and Evolutionary Biology

The landscape of undergraduate biology education is populated by diverse and innovative efforts to engage and motivate learners. However, these projects are generally isolated, often resource intensive, and rarely have impacts beyond the original context of their development. Understanding more about how to foster and sustain science education reform including support for the implementation of new materials in diverse classrooms is widely recognized as a wicked problem. I coordinate the Quantitative Undergraduate Biology Education & Synthesis (QUBES) project which acts as a scientific gateway for biology education reform by providing access to community specific tools, opportunities for collaboration, and data resources. We have integrated a set of social norms with our technical infrastructure to promote teaching scholarship through faculty communities of practice, publication of open education resources, and impact metrics. This suite of resources and tools has been embraced by a broad interdisciplinary consortium of projects, professional societies, institutions, and organizations who are vested in the development of biology students’ quantitative reasoning skills. This seminar will share findings from our ongoing work in promoting reform uptake and describe next steps including an emphasis on teaching with data and building data literacy skills.

View YouTube video of seminar: https://youtu.be/HQbx0SFJn4U

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Lecture / Discussion Tue, 27 Mar 2018 16:05:20 -0400 2018-03-15T16:00:00-04:00 2018-03-15T17:00:00-04:00 Chemistry Dow Lab Ecology and Evolutionary Biology Lecture / Discussion Graph on teaching practices
Making, Breaking, and Linking Memories (March 16, 2018 12:15pm) https://events.umich.edu/event/47202 47202-10813718@events.umich.edu Event Begins: Friday, March 16, 2018 12:15pm
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Sara Aton

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Workshop / Seminar Wed, 21 Feb 2018 10:06:00 -0500 2018-03-16T12:15:00-04:00 2018-03-16T13:15:00-04:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar cartoon of neuron with trophy
Thesis Defense: Applications of Raman Microspectroscopy to the Study of Atmospheric Aerosol Particles (March 16, 2018 1:00pm) https://events.umich.edu/event/49921 49921-11577478@events.umich.edu Event Begins: Friday, March 16, 2018 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Rebecca L. Craig (Advisor: Andrew Ault)

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Other Fri, 16 Mar 2018 18:15:36 -0400 2018-03-16T13:00:00-04:00 2018-03-16T14:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title:“Dynamics of Translation” (March 16, 2018 4:00pm) https://events.umich.edu/event/48519 48519-11243808@events.umich.edu Event Begins: Friday, March 16, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Translation of proteins by the ribosome is intrinsically dynamic, involving specific assembly of ribosomes on an mRNA, elongation of the polypeptide chain through directional movement on that mRNA, and subsequent termination and recycling of the subunits. We have developed single-molecule approaches, combined with structural methods, to provide a real time view of translation and its control. We will show how translation elongation is controlled by RNA structure, nascent peptides and drugs.

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Workshop / Seminar Wed, 07 Mar 2018 10:57:02 -0500 2018-03-16T16:00:00-04:00 2018-03-16T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Joseph Puglisi
Titration of a Single Molecule of DNA in a Protein Nanoreactor (March 20, 2018 4:00pm) https://events.umich.edu/event/50282 50282-11701587@events.umich.edu Event Begins: Tuesday, March 20, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Measurement of single molecule reactions can elucidate microscopic mechanisms that are often hidden from ensemble analysis. We describe the acid-base titration of a single DNA duplex confined within the α-hemolysin (α-HL) nanopore for up to 4 h, while monitoring the ionic current through the nanopore. Modulation between two states in the current-time trace for duplexes containing the C:C mismatch in proximity to the latch constriction of α-HL is attributed to the base flipping of the C:C mismatch. As the pH is lowered, the rate for the C:C mismatch to flip from the intra-helical state to the extra-helical state decreases, while the rate for base flipping from the extra-helical state to the intra-helical state remains unchanged. Analysis of the pH-dependent kinetics of base flipping using a hidden Markov kinetic model demonstrates that protonation/deprotonation occurs while the base pair is in the intra-helical state. We also demonstrate that the rate of protonation is limited by transport of H+ into the α-HL nanopore. Our experiments correspond to the longest single-molecule measurements performed using a nanopore, and demonstrate its application in interrogating mechanisms of single-molecule reactions in confined geometries.











Henry White (University of Utah)

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Other Mon, 19 Mar 2018 06:15:31 -0400 2018-03-20T16:00:00-04:00 2018-03-20T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: From Small Molecules to Polymers: Linear and Nonlinear Optical Properties of Organic Conjugated Systems for Solar Applications (March 22, 2018 11:00am) https://events.umich.edu/event/51085 51085-11956307@events.umich.edu Event Begins: Thursday, March 22, 2018 11:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Bradley Keller (Advisor: Prof. Theodore Goodson III)

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Other Thu, 22 Mar 2018 18:15:34 -0400 2018-03-22T11:00:00-04:00 2018-03-22T12:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
EEB Thursday Seminar: Avian speciation in the tropics (March 22, 2018 4:00pm) https://events.umich.edu/event/49259 49259-11397842@events.umich.edu Event Begins: Thursday, March 22, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Ecology and Evolutionary Biology

My talk will summarize our efforts to understand the evolutionary factors underlying the extraordinary richness of Neotropical bird species. I will present data collected at multiple taxonomic scales, including phylogenomic analyses of large bird radiations and fine-scale population genetic analyses of single species. These data highlight the importance of the physical landscape in driving speciation, but, contrary to much biogeographic theory, provide scant evidence that specific events in Earth history have influenced speciation in a unified fashion. Instead, the relative timing of speciation events within lineages is largely idiosyncratic and influenced primarily by natural history characteristics of the species, such as dispersal ability.

View YouTube video of seminar: https://youtu.be/V55JU1ZnLHM

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Lecture / Discussion Tue, 27 Mar 2018 16:05:55 -0400 2018-03-22T16:00:00-04:00 2018-03-22T17:00:00-04:00 Chemistry Dow Lab Ecology and Evolutionary Biology Lecture / Discussion Species map of tropical birds
Of comprehension and text: Studies of language and learning chemistry (March 22, 2018 4:00pm) https://events.umich.edu/event/47252 47252-10849571@events.umich.edu Event Begins: Thursday, March 22, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

While mathematical ability has long been implicated as crucial for learning chemistry, language ability remains largely uninvestigated. This contribution explores correlations between language comprehension and performance in general chemistry, as well as how general chemistry students interact with text-based learning materials. Structure Building, a model that describes how linguistic information is incorporated into one’s existing knowledge base, guides our work. We demonstrate that comprehension ability correlates strongly with chemistry course performance. An examination of variables predicted to interact by the Structure Building Framework suggests that high comprehension ability may be sufficient to compensate for low prior knowledge. We also report the design and analysis of a multiple-testing intervention strategy that differentially aids those of low comprehension ability. The effect of question type (multiple choice versus elaborative interrogation) on this multiple-quizzing strategy has also been investigated. With regard to text-based learning materials, we carried out linguistic analyses of popular general chemistry texts, the results of which suggest that these materials are appropriate for only low-knowledge students. Further studies probing the extent to which students benefit from reading texts on chemical bonding and redox concepts revealed an expertise reversal effect, corroborating these textual analyses.














Sam Pazicni (University of New Hampshire)

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Other Thu, 22 Mar 2018 18:15:34 -0400 2018-03-22T16:00:00-04:00 2018-03-22T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seeing and Understanding Biology, One Molecule at a Time (March 23, 2018 12:15pm) https://events.umich.edu/event/47203 47203-10813719@events.umich.edu Event Begins: Friday, March 23, 2018 12:15pm
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Anthony Vecchiarelli

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Workshop / Seminar Thu, 01 Mar 2018 16:24:09 -0500 2018-03-23T12:15:00-04:00 2018-03-23T13:15:00-04:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar one molecule highlighted
Thesis Defense: Advances in Glucose Sensing Techniques: Novel Non-Invasive and Continuous Electrochemical Glucose Monitoring Systems (March 26, 2018 3:00pm) https://events.umich.edu/event/51086 51086-11956308@events.umich.edu Event Begins: Monday, March 26, 2018 3:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Kyoung Ha Cha (Advisor: Prof. Mark E. Meyerhoff)

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Other Mon, 26 Mar 2018 18:15:29 -0400 2018-03-26T15:00:00-04:00 2018-03-26T16:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
The When, Why, and How of Flow Chemistry (March 26, 2018 4:00pm) https://events.umich.edu/event/50283 50283-11701588@events.umich.edu Event Begins: Monday, March 26, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Flow chemistry has the potential to revolutionize the synthesis of organic molecules. Flow systems can reduce reaction times, increase efficiency, and obviate problems often encountered in scaling up. In addition to these important practical advantages, flow chemistry expands the “toolbox” of organic reactions available to scientists engaged in the synthesis of molecules – from small-scale experiments to large-scale production. These benefits are a direct result of several features of flow synthesis that batch synthesis typically cannot achieve, for example, the ability to control fluid flow precisely, the access to temperature and pressure regimes not usually considered to be practical, and the enhanced safety characteristics of flow chemical systems. In this lecture we will discuss some of our investigations in this area in the form of case studies, wherein a specific target or family of organic molecules has served as an inspiration for the development of new methods of organic synthesis in flow. Flow chemistry represents an important conceptual advance in the design and execution of chemical syntheses.


















Timothy Jamison (Massachusetts Institute of Technology)

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Other Mon, 26 Mar 2018 18:15:29 -0400 2018-03-26T16:00:00-04:00 2018-03-26T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Electrochemical sensors and scanning electrochemical sensors (SECM): a new tool to study biomaterials and associated biofilms (March 27, 2018 4:00pm) https://events.umich.edu/event/50284 50284-11701589@events.umich.edu Event Begins: Tuesday, March 27, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

My research program at Oregon State University is involved in developing new electrochemical sensors to study microbial metabolism at high spatial and temporal resolution. We are specifically interested in studying bacterial metabolic interactions with other bacterial species, biomaterials,
and the immediate microenvironment surrounding the bacteria. We have developed micron-sized Ca2+, pH, H2O2, NH4+ and lactate sensors to be used as a chemical probe in scanning electrochemical microscopy (SECM) to quantitatively map the local chemical environment produced by live dental biofilms and their effects on the integrity of the dental composites. In
addition, we are also involved in synthesizing a variety of glucose-modified dendron molecules to construct bacterial microhabitat using 3D hydrogel printing to study the bacterial metabolic interactions between different bacterial species.


















Dipankar Koley (Oregon State University)

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Other Tue, 27 Mar 2018 18:15:28 -0400 2018-03-27T16:00:00-04:00 2018-03-27T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Protonic solar cells by sensitization of passive ion-selective polymers with photoacid dyes (March 28, 2018 4:00pm) https://events.umich.edu/event/50235 50235-11690312@events.umich.edu Event Begins: Wednesday, March 28, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Most electrochemical technologies that operate under ambient conditions require ion-conducting polymer electrolytes. These polymers are passive in that electric bias drives ion migration in the thermodynamically favored direction. Recently, my group engineered two important features into passive ion-selective polymers to introduce the active function of photovoltaic action and demonstration of an ionic solar cell. These features were covalent bonding of photoacid dyes to the polymers such that absorption of visible light resulted in liberation of protons, and synthesis of polymer membranes with charge-selective contacts to facilitate separation and collection of H+ and OH–. Light excitation from either side of the polymer membranes resulted in H+ dissociation followed by directional charge collection. The charge collection direction was dictated by the electrostatic asymmetry in the polymers, which was formed due to an external pH difference setup across the membrane.

Joining a monopolar cation-selective polymer to a monopolar anion-selective polymer forms a bipolar membrane, which mimics a rectifying semiconductor pn-junction diode in form and function, and is able to maintain pH differences across it. Using a photoacid-dye-modified bipolar membrane, we measured a photovoltage of ~120 mV under conditions of solar-simulated excitation. In addition to more traditional electrochemical techniques, insights into materials function were obtained using finite-element numerical modeling of photoacid kinetics and membrane physics; beam-line x-ray scattering measurements; electrochemical impedance, solid-state NMR, and pulsed-laser spectroscopies; and fluorescence, electron, and force microscopies. Collectively, these photo-responsive polymers represent a new class of functional materials that use light to trigger changes in local ion concentration and electrostatic potential. These local changes can be used to affect macroscopic processes such as direct sunlight-driven redox chemistry or desalination of salt water, chemical catalysis, and triggering of cellular processes.

References
(1) Reiter, R. S.; White, W.; Ardo, S. Journal of The Electrochemical Society, 2016, 163, H3132–H3134. Electrochemical characterization of commercial bipolar membranes under electrolyte conditions relevant to solar fuels technologies.
(2) White, W.; Sanborn, C. D.; Reiter, R. S.; Fabian, D. M.; Ardo, S. Journal of the American Chemical Society, 2017, 139, 11726–11733. Observation of photovoltaic action from photoacid-modified Nafion due to light-driven ion transport.
(3) White, W.; Sanborn, C. D.; Fabian, D. M.; Ardo, S. Joule, 2018, 2, 94–109. Conversion of visible light into ionic power using photoacid-dye-sensitized bipolar ion-exchange membranes.












Shane Ardo (University of California Irvine)

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Other Wed, 28 Mar 2018 18:15:30 -0400 2018-03-28T16:00:00-04:00 2018-03-28T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
EEB Thursday Seminar: Genome variation and mutation in yeast mitochondrial genomes (March 29, 2018 4:00pm) https://events.umich.edu/event/49177 49177-11386612@events.umich.edu Event Begins: Thursday, March 29, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Ecology and Evolutionary Biology

Mitochondria are the powerhouse of the cell, and they encode their own DNA. Yeast mitochondrial DNAs are of striking difference in genome architectures and mutation rates. I will discuss some evolutionary and functional aspects of such fascinating variation regarding yeast mitochondrial DNAs.

View YouTube video of seminar: https://youtu.be/u9xyOGc3AMU

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Lecture / Discussion Tue, 10 Apr 2018 15:42:42 -0400 2018-03-29T16:00:00-04:00 2018-03-29T17:00:00-04:00 Chemistry Dow Lab Ecology and Evolutionary Biology Lecture / Discussion Chemistry Dow Lab
Oxyfunctionalization of Remote C–H Bonds of Aliphatic Amines via Decatungstate Photocatalysis (March 29, 2018 4:00pm) https://events.umich.edu/event/47056 47056-10779760@events.umich.edu Event Begins: Thursday, March 29, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Derivatized aliphatic amines represent a common and important class of chemical building blocks prevalent in the pharmaceutical, agrochemical and material industry. As a result, approaches to directly install functionality on simple and unbiased amine precursors remain of paramount importance. While functionalizing alpha to the nitrogen has been well-studied and numerous methods exist, achieving remote amine functionalization remains largely underdeveloped. Consequently, we reasoned that a direct and protecting group free oxygenation of aliphatic amines (to arrive at keto-amine products) would provide an ideal means for introducing diverse functionality. Through the use of high throughput experimentation (HTE) a photochemical oxidation was identified that relied upon hydrogen peroxide (or oxygen) as the oxidant in combination with a non-precious metal photocatalyst. These conditions were shown to selectively oxidize a series of diverse aliphatic amine starting materials to their remotely oxidized analogs and was amenable to scale-up in flow.
















Danielle Schultz (Merck - Enabling Technologies Group)

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Other Thu, 29 Mar 2018 18:15:29 -0400 2018-03-29T16:00:00-04:00 2018-03-29T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
CALCIUM Event (March 30, 2018 12:00am) https://events.umich.edu/event/48255 48255-11194113@events.umich.edu Event Begins: Friday, March 30, 2018 12:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry










Jason Rohde (NIH/NCATS)

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Other Fri, 30 Mar 2018 18:15:34 -0400 2018-03-30T00:00:00-04:00 2018-03-30T00:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
3D Genome and Polycomb in Development and Epigenetic Inheritance (March 30, 2018 12:15pm) https://events.umich.edu/event/47204 47204-10813720@events.umich.edu Event Begins: Friday, March 30, 2018 12:15pm
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Head of the Institute of Human Genetics, Montpellier, France
Host: Monica Dus

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Workshop / Seminar Tue, 20 Mar 2018 16:51:28 -0400 2018-03-30T12:15:00-04:00 2018-03-30T13:15:00-04:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar combination of science images of analysis, microscope images
Thesis Defense: "Homogeneous, Heterogeneous, and Heterogenized-Homogeneous Catalytic Hydrogenation for the Cascade Conversion of Carbon Dioxide to Methanol" (March 30, 2018 1:00pm) https://events.umich.edu/event/51249 51249-12024284@events.umich.edu Event Begins: Friday, March 30, 2018 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Danielle Samblanet (Advisor: Prof. Melanie Sanford)

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Other Fri, 30 Mar 2018 18:15:34 -0400 2018-03-30T13:00:00-04:00 2018-03-30T14:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: "Engineering Biochemical Systems Using A Cell-Free Expression Toolbox" (March 30, 2018 4:00pm) https://events.umich.edu/event/48522 48522-11243811@events.umich.edu Event Begins: Friday, March 30, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

I will present an all E. coli cell-free expression platform (TXTL) specifically developed to construct and characterize dynamical systems programmed with gene circuits executed in either test tube reactions, microfluidics or cell-sized liposomes. TXTL is used in many applications from prototyping single gene regulatory elements to the complete synthesis of bacteriophages and the assembly of synthetic cell analogs.

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Workshop / Seminar Tue, 27 Mar 2018 10:11:26 -0400 2018-03-30T16:00:00-04:00 2018-03-30T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Vincent Noireaux
Thesis Defense: Finite-temperature Green’s Function Methods for ab-initio Quantum Chemistry (April 3, 2018 10:00am) https://events.umich.edu/event/51506 51506-12126781@events.umich.edu Event Begins: Tuesday, April 3, 2018 10:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Alicia Rae Welden (Advisor: Dominika Zgid)

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Other Tue, 03 Apr 2018 18:15:26 -0400 2018-04-03T10:00:00-04:00 2018-04-03T11:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
ELI Winter Workshop Series: Power Up Your English with Great Self-Study Apps + Sites (April 3, 2018 12:00pm) https://events.umich.edu/event/48485 48485-11241175@events.umich.edu Event Begins: Tuesday, April 3, 2018 12:00pm
Location: Chemistry Dow Lab
Organized By: English Language Institute

There are so many free websites and apps for improving English that it can be hard to find the really useful ones, especially for advanced speakers and writers. In this hands-on workshop, you will learn about a small set of powerful English sites and apps and practice techniques for using these tools to take your advanced English writing and speaking to the next level. We will look at resources for improving speaking, listening, writing, reading, and vocabulary. Bring your laptop, tablet, or phone to try things out on your own device during the workshop.

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Workshop / Seminar Mon, 12 Mar 2018 10:47:07 -0400 2018-04-03T12:00:00-04:00 2018-04-03T14:00:00-04:00 Chemistry Dow Lab English Language Institute Workshop / Seminar ELI Winter Workshop Series
Lipid Corona Formation from Nanoparticle Interactions with Bilayers and Membrane-Specific Biological Outcomes (April 3, 2018 4:00pm) https://events.umich.edu/event/44504 44504-9923098@events.umich.edu Event Begins: Tuesday, April 3, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

While mixing nanoparticles with certain biological molecules can result in coronas that afford some control over how engineered nanomaterials interact with living systems, corona formation mechanisms remain enigmatic. Here, we report spontaneous lipid corona formation, i.e. without active mixing, upon attachment to stationary lipid bilayer model membranes and bacterial cell envelopes, and present ribosome-specific outcomes for multi-cellular organisms. Experiments show that polycation-wrapped particles disrupt the tails of zwitterionic lipids, increase bilayer fluidity, and leave the membrane with reduced ζ-potentials. Computer simulations show contact ion pairing between the lipid headgroups and the polycations’ ammonium groups leads to the formation of stable, albeit fragmented, lipid bilayer coronas, while microscopy shows fragmented bilayers around nanoparticles after interacting with Shewanella oneidensis. Our mechanistic insight can be used to improve control over nano-bio interactions and to help understand why some nanomaterial/ligand combinations are detrimental to organisms, like Daphnia magna, while others are not.








Franz Geiger (Northwestern University)

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Other Tue, 03 Apr 2018 18:15:25 -0400 2018-04-03T16:00:00-04:00 2018-04-03T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Engineering Cross Campus Transfer Orientation (April 3, 2018 5:30pm) https://events.umich.edu/event/50875 50875-11893579@events.umich.edu Event Begins: Tuesday, April 3, 2018 5:30pm
Location: Chemistry Dow Lab
Organized By: Michigan Engineering Transfer Support (METS)

Welcome to the College of Engineering! Learn more about the College, how to get connected, and how to register for your Fall Term classes correctly. Dinner will be served! RSVP required: https://goo.gl/forms/QXwsSpJAviDkBFtN2

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Meeting Fri, 09 Mar 2018 11:39:15 -0500 2018-04-03T17:30:00-04:00 2018-04-03T19:00:00-04:00 Chemistry Dow Lab Michigan Engineering Transfer Support (METS) Meeting M Engr Logo
Organic Chemistry at the Interface of Materials and Mechanics (April 4, 2018 2:00pm) https://events.umich.edu/event/50529 50529-11793843@events.umich.edu Event Begins: Wednesday, April 4, 2018 2:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

In this talk, I will discuss the molecular design of organic
structural materials that mimic the ability of living systems to
protect, report, heal and even regenerate themselves in response to
damage, with the goal of increasing lifetime, safety and
sustainability of many manufactured items. I will emphasize recent
developments in frontal ring-opening metathesis polymerization (FROMP)
to manufacture composites with minimal energy consumption. The talk
will also present a workflow for the design, evaluation, and
development of new “mechanophores”, a term that has come to mean a
molecular unit that chemically responds in a selective manner to a
mechanical perturbation. Mechanophores are building blocks for the
development of mechanoresponsive materials with protection and sensing
functions. The impact and challenges of introducing these capabilities
in real-world situations will be mentioned.


Jeffrey Moore (UIUC)

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Other Wed, 04 Apr 2018 18:15:30 -0400 2018-04-04T14:00:00-04:00 2018-04-04T15:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
There is plenty of room at the bottom just no room for error (April 4, 2018 4:00pm) https://events.umich.edu/event/49143 49143-11378285@events.umich.edu Event Begins: Wednesday, April 4, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our research focuses on the rational design, deterministic assembly, and detailed investigation of the physical phenomena emerging from quantum confinement effects in graphene nanomaterials. We pursue a highly integrated multidisciplinary program, founded on synthetic bottom-up approaches toward functional materials with precisely defined structure. We control their assembly into hierarchically ordered architectures, and evaluate inherent physical properties using modern scanning probe techniques across multiple length, time, and energy scales. The technological advancements enabled through our research have sparked the development of low-energy high-performance computing architectures, the next generation of energy conversion nanocatalysts and storage systems, and have established surface mediated chemical transformations as competent synthetic methodologies for target-directed organic synthesis.
















Felix Fischer (UC Berkeley)

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Other Wed, 04 Apr 2018 18:15:30 -0400 2018-04-04T16:00:00-04:00 2018-04-04T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Illuminating acetylation’s dark matter with chemoproteomics (April 5, 2018 2:00pm) https://events.umich.edu/event/50712 50712-11853302@events.umich.edu Event Begins: Thursday, April 5, 2018 2:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

A paradox of modern acetylation biology is that the while number of sites of acetylation has climbed rapidly, the number of enzymes thought to catalyze this process has stayed relatively constant. Here we describe the utility of chemical proteomic methods to discover and characterize novel mechanisms of acetylation in endogenous cellular contexts. Our studies highlight an expanded landscape of regulatory acetylation in gene expression control, as well as new strategies to investigate the metabolic regulation and small molecule inhibition of acetyltransferases in cells.










Jordan Meier (National Cancer Institute)

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Other Thu, 05 Apr 2018 18:15:29 -0400 2018-04-05T14:00:00-04:00 2018-04-05T15:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
EEB Thursday Seminar: Demographic compensation and tipping points in climate-induced range shifts (April 5, 2018 4:00pm) https://events.umich.edu/event/49261 49261-11397844@events.umich.edu Event Begins: Thursday, April 5, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Ecology and Evolutionary Biology

Understanding the demographic mechanisms setting geographical range limits may be key to predicting how species’ ranges will shift under climate change. Using data from a 20+ year demographic study of two tundra plants across their latitudinal ranges in North America, I show that different demographic rates change in opposite directions (“demographic compensation”) across latitudes, which may buffer populations across the range from environmental change. However, we have also found evidence that compensation may break down suddenly once a warming tipping point has been surpassed. Evidence for local adaptation suggests tipping points may paradoxically be reached sooner at the colder rather than the warmer end of the gradient, which may lead to counterintuitive range shifts under climate change.

View YouTube video of seminar: https://youtu.be/gyfwX8J6hgE

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Lecture / Discussion Tue, 10 Apr 2018 15:43:24 -0400 2018-04-05T16:00:00-04:00 2018-04-05T17:00:00-04:00 Chemistry Dow Lab Ecology and Evolutionary Biology Lecture / Discussion mountain scenery, flowers growing in rocks
Thesis Defense: Investigations of Structural Changes of Microelectronic Polymers and Adhesives (April 9, 2018 2:00pm) https://events.umich.edu/event/51695 51695-12196743@events.umich.edu Event Begins: Monday, April 9, 2018 2:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Nathan Ulrich (Advisor: Prof. Zhan Chen)

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Other Mon, 09 Apr 2018 18:15:20 -0400 2018-04-09T14:00:00-04:00 2018-04-09T15:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Evolution of catalysis and regulation over 3.5 billion years- Exploitation for novel cancer drugs (April 9, 2018 4:00pm) https://events.umich.edu/event/49169 49169-11386597@events.umich.edu Event Begins: Monday, April 9, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


Allosteric regulation, the process by which a protein’s activity can be modulated by binding of an effector molecule distal to the active site, is vital for cellular signaling. However, its evolution is largely unexplored territory. I will describe our experimental exploration of the evolution over 1.5 billion years of two allosteric regulation mechanisms widely found in the modern protein kinase superfamily, phosphorylation of the activation loop and binding of a regulatory partner protein. Using Ancestral Sequence Reconstruction (ASR) we unravel the origins of allosteric activation including surprising mechanistic features. Moreover, ASR enabled identification of the underlying allosteric network that spans the kinase from the N-terminal to the C-terminal lobes. In the second part of the talk I describe how we exploit this new knowledge for the development of allosteric inhibitors and activators. This latter approach delivered novel kinase inhibitors and activators with extreme specificity and high affinity thereby opening the road to new cancer treatment. Third, I will address the evolution of enzyme catalysis in response to one of the most fundamental evolutionary drivers, temperature. Using ASR, we answer the question of how enzymes coped with an inherent drop in catalytic speed caused as the earth cooled down over 3.5 billion years. Tracing the evolution of enzyme activity and stability from the hot-start towards modern hyperthermophilic, mesophilic and psychrophilic organisms illustrates active pressure versus passive drift in evolution on a molecular level.

















Dorothee Kern (Brandeis University)

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Other Mon, 09 Apr 2018 18:15:20 -0400 2018-04-09T16:00:00-04:00 2018-04-09T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Going Through a Phase: Particulate Water in Atmospheric Aerosol (April 10, 2018 4:00pm) https://events.umich.edu/event/43565 43565-9821428@events.umich.edu Event Begins: Tuesday, April 10, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


The water content of atmospheric aerosols controls many properties including their ability to catalyze heterogeneous chemical reactions, their impact on climate and visibility, and their ability to form clouds. In the atmosphere, the water content of the particles depends on their composition as well as the relative humidity and temperature. As crystalline salt particles are exposed to increasing relative humidity, the deliquescence phase transition results in rapid formation of aqueous droplets at the deliquescence relative humidity (DRH). The DRH values of atmospheric salts are generally well predicted by theory. In contrast, decreasing relative humidity results in particle morphologies and water content that are difficult to predict theoretically, and must be measured in the laboratory. At sufficiently low relative humidity, the droplets may undergo efflorescence (at the ERH), resulting in recrystallization of the salt particles. Hysteresis in water uptake and loss is often observed and the DRH can be very much higher than the ERH. Thus atmospheric salt particles are often assumed to be aqueous throughout much of their atmospheric lifetime. Here we use a long working distance optical trap to measure the deliquescence and efflorescence phase transitions of individual levitated salt particles. In addition, we probe how efflorescence is influenced by collisions of the salt droplet with other particles and by immersion of solids within the droplet. We find that while both contact and immersion can promote efflorescence, contact-induced efflorescence is by far more effective. These laboratory experiments challenge our theoretical understanding of nucleation in microscopic salt particles. In addition, the experiments have implications for particle phase and water content of aerosols in the global atmosphere.







Margaret Tolbert (University of Colorado)

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Other Tue, 10 Apr 2018 18:15:23 -0400 2018-04-10T16:00:00-04:00 2018-04-10T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Instructional resources that promote visualization of chemical phenomena (April 11, 2018 4:00pm) https://events.umich.edu/event/45094 45094-10084360@events.umich.edu Event Begins: Wednesday, April 11, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Finding alternative ways to observe objects or processes that cannot be seen by the naked eye is critical in chemistry instruction. We have developed a variety of instructional resources that have shown effectiveness in promoting visualization and consequently, understanding of chemical concepts. Projects that will be highlighted include the use of 3D printed models to study macromolecular structure & interactions and analogies that assist students in connecting core scientific concepts to the nanoscale. Studies have used qualitative methods to monitor the impact of the instructional materials on students’ learning. This presentation will give an overview of these instructional resources and the evidence that speaks to their effectiveness in the classroom.














Maria Oliver-Hoyo (NC State University)

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Other Wed, 11 Apr 2018 18:15:22 -0400 2018-04-11T16:00:00-04:00 2018-04-11T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
EEB Thursday Seminar: Molecular evolution of visual pigments (April 12, 2018 4:00pm) https://events.umich.edu/event/49262 49262-11397845@events.umich.edu Event Begins: Thursday, April 12, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Ecology and Evolutionary Biology

Abstract
The initial step in vision in all vertebrates is triggered via absorption of a photon by a visual pigment located in the photoreceptors of the eye. Variation in the functional properties of visual pigments can therefore have profound consequences on the visual capabilities of an organism. The visual system has a surprisingly large dynamic range, and is highly specialized for the efficient sensing of light in extremely diverse light environments. How is this achieved at the molecular level? My laboratory studies these and other questions such as the mechanisms of spectral tuning, and the evolution of color vision, using a variety of interdisciplinary approaches, including ancestral reconstruction, computational sequence analysis, site-directed mutagenesis and protein expression in mammalian and yeast systems.

View YouTube video of seminar: https://youtu.be/b8CVmp5n0nI

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Lecture / Discussion Tue, 17 Apr 2018 15:33:09 -0400 2018-04-12T16:00:00-04:00 2018-04-12T17:00:00-04:00 Chemistry Dow Lab Ecology and Evolutionary Biology Lecture / Discussion drawing of an eye with phylogeny as pupil
Strategies and methods for the synthesis of neuroactive disulfide-linked peptides (April 12, 2018 4:00pm) https://events.umich.edu/event/41564 41564-9362949@events.umich.edu Event Begins: Thursday, April 12, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Research in the Stockdill group is focused on the design of elegant and efficient strategies for the synthesis of neuroactive molecules ranging from complex alkaloids to disulfide-linked mini-proteins and for the detection of neurotransmitters. In the course of these efforts, we explore chemical reactivity and develop new reaction methods. This seminar will highlight our recent progress toward the synthesis of multi-disulfide containing conotoxins as well as the development new synthetic methods for peptide synthesis that have resulted from these synthetic studies.











Jennifer Stockdill (Wayne State University)

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Other Thu, 12 Apr 2018 18:15:56 -0400 2018-04-12T16:00:00-04:00 2018-04-12T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Bacterial Amyloid Curli: Interactions with DNA and Pathogenicity (April 13, 2018 12:15pm) https://events.umich.edu/event/47205 47205-10813721@events.umich.edu Event Begins: Friday, April 13, 2018 12:15pm
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Matt Chapman

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Workshop / Seminar Mon, 08 Jan 2018 11:01:30 -0500 2018-04-13T12:15:00-04:00 2018-04-13T13:15:00-04:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar microscopic image of lumen
Improving the Prediction of In vivo Drug Activity (April 13, 2018 1:30pm) https://events.umich.edu/event/51856 51856-12265830@events.umich.edu Event Begins: Friday, April 13, 2018 1:30pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Peter J Tonge (Stony Brook University)

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Other Fri, 13 Apr 2018 18:15:26 -0400 2018-04-13T13:30:00-04:00 2018-04-13T00:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
"Insight from biophysical studies on the mechanism of strong Ca2+-dependent membrane binding by synaptotagmin-7 " (April 13, 2018 4:00pm) https://events.umich.edu/event/51399 51399-12098133@events.umich.edu Event Begins: Friday, April 13, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Synaptotagmin (Syt) proteins comprise a 17-member family of exocytosis regulators, several of which serve as Ca2+-sensing triggers for SNARE-catalyzed membrane fusion. Ca2+ dependence arises from two C-terminal C2 domains (termed C2A and C2B) that insert into anionic lipid membranes upon binding two or three Ca2+ ions. Of the Ca2+-sensitive isoforms, Syt-7 has recently emerged as a topic of broad interest due to its extreme Ca2+ sensitivity and roles in a diverse range of secretion events. Both C2 domains of Syt-7 (but especially C2A) bind and insert into membranes at much lower Ca2+ concentrations and dissociate more slowly than the corresponding domains from the more widely studied isoform Syt-1. We have used a combination of spectroscopic, single-molecule, and computational approaches to understand the physical-chemical origins of this strong membrane binding. The results show intriguing distinctions between Syt-1 and Syt-7, including deeper hydrophobic membrane insertion and more efficient membrane bridging by the Syt-7 C2A domain as well as diminished interdomain cooperativity in the Syt-7 C2AB tandem. Similarities between Syt-1 and Syt-7 inform models for a common mechanism of Syt/SNARE/Ca2+-mediated membrane fusion. Differences may contribute to the known points of divergence between the two isoforms, such as the rate of fusion pore expansion.

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Workshop / Seminar Tue, 27 Mar 2018 14:04:28 -0400 2018-04-13T16:00:00-04:00 2018-04-13T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Jefferson Knight
Bridging Molecular and Heterogeneous Electrocatalysis Through Graphite Conjugation (April 16, 2018 4:00pm) https://events.umich.edu/event/49170 49170-11386598@events.umich.edu Event Begins: Monday, April 16, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The efficient interconversion of electrical and chemical energy requires catalysts capable of accelerating complex multi-electron reactions at electrified interfaces. These reactions can be carried out at the metallic surface sites of heterogeneous electrocatalysts or via redox mediation at molecular electrocatalysts. Molecular catalysts yield readily to synthetic alteration of their redox properties and secondary coordination sphere, permitting systematic tuning of their activity and selectivity. Similar control is difficult to achieve with heterogeneous electrocatalysts because they typically exhibit a distribution of active site geometries and local electronic structures, which are recalcitrant to molecular-level synthetic modification. However, metallic heterogeneous electrocatalysts benefit from a continuum of electronic states which distribute the redox burden of a multi-electron transformation, enabling more efficient catalysis. We have developed a simple synthetic strategy for conjugating well-defined molecular catalyst active sites with the extended states of graphitic solids. Electrochemical and spectroscopic data indicate that these graphite-conjugated catalysts do not behave like their molecular analogs, but rather as metallic active sites with molecular definition, providing a unique bridge between the traditionally disparate fields of molecular and heterogeneous electrocatalysis.











Yogesh Surendranath (Massachusetts Institute of Technology)

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Other Mon, 16 Apr 2018 18:15:15 -0400 2018-04-16T16:00:00-04:00 2018-04-16T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Single protein dynamics at soft interfaces: Can physical chemistry solve a $100,000,000,000 problem? (April 17, 2018 4:00pm) https://events.umich.edu/event/48445 48445-11235884@events.umich.edu Event Begins: Tuesday, April 17, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Understanding nanoscale protein dynamics at interfaces is crucial for topics ranging from disease inception and drug delivery to separations science. Recent efforts by our group and others have shown the promise of applying single molecule methods to link mechanistic detail about protein adsorptions to macroscale observables. When we study one molecule at a time, we eliminate ensemble averaging, thereby accessing any underlying complexity. However, we must develop new methods to increase information content in the resulting low density and low signal-to-noise data and to improve space and time resolution.

I will highlight recent advances in super-resolution microscopy for quantifying the physics and chemistry that occur between target proteins and stationary phase supports during chromatographic separations. My discussion will concentrate on the newfound ability of super-resolved single protein spectroscopy to inform theoretical parameters via quantification of adsorption-desorption dynamics, protein unfolding, and nano-confined transport.

















Christy Landes (Rice University)

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Other Tue, 17 Apr 2018 18:15:15 -0400 2018-04-17T16:00:00-04:00 2018-04-17T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: Development and Mechanistic Implications of Nickel Pre-Catalysts for Organic Synthesis (April 18, 2018 12:00pm) https://events.umich.edu/event/51708 51708-12205468@events.umich.edu Event Begins: Wednesday, April 18, 2018 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Alex J. Nett (Advisor: Profs. John Montgomery & Paul Zimmerman)

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Other Wed, 18 Apr 2018 18:15:16 -0400 2018-04-18T12:00:00-04:00 2018-04-18T13:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: Advances Towards Regioselective Synthesis of Secondary Alkylboranes and 1,2-cis Glycosides  (April 19, 2018 3:00pm) https://events.umich.edu/event/51696 51696-12196744@events.umich.edu Event Begins: Thursday, April 19, 2018 3:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Hilary Kerchner (Advisor: Prof. John Montgomery)

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Other Thu, 19 Apr 2018 18:15:17 -0400 2018-04-19T15:00:00-04:00 2018-04-19T16:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
CANCELLED: Visible and Near-Infrared Emitting Lanthanide(III)-Based Compounds for Biological Applications (April 19, 2018 4:00pm) https://events.umich.edu/event/47220 47220-10824750@events.umich.edu Event Begins: Thursday, April 19, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Trivalent lanthanide(III) ions, Ln3+, due to their specific electronic configuration ([Xe]4fn, n = 0–14) and the shielding of their 4f orbitals by the outer 5s25p6 subshells exhibit unique optical properties, in particular (i) sharp characteristic bands arising from f-f transitions in the entire spectrum from UV to near-infrared (NIR) domains, the wavelengths of which are insignificantly affected by changes in the local microenvironment around Ln3+ (pH, temperature, hydrophilic and hydrophobic character of biological molecules) and (ii) long luminescence lifetimes compared to organic fluorophores (ns-µs or µs-ms range for NIR- or visible-emitting Ln3+, respectively). However, extremely low molar absorption coefficients of free Ln3+ require their sensitization by the “antenna effect” via appropriate chromophoric ligands in order to obtain a sufficient emission intensity. Therefore, the design of highly luminescent Ln3+ compounds requires an optimization of the sensitization processes as well as the minimization of non-radiative deactivation mechanisms through overtones of high-energy vibrations, charge-transfer states and back energy transfer. Moreover, if Ln3+ coordination compounds are thought to be used in a specific application, additional requirements such as water solubility, biocompatibility, low toxicity, high thermodynamic stability and/or kinetic inertness for biological applications, have to be taken into account.
In this presentation, we will show the way from the design and synthesis to the use of highly luminescent lanthanide(III) coordination compounds emitting in the visible and the NIR ranges for biological applications. Particular attention will be given to the detailed analysis of photophysical properties in view of their possible rationalization. Ln3+-based small molecular complexes (polyaminocarboxylates, metallacrowns), macromolecules (dendrimers), coordination polymers and nanomaterials will be discussed.














Svetlana Eliseeva (Centre Moleculaire Biophysique in Orleans, France)

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Other Tue, 17 Apr 2018 06:15:13 -0400 2018-04-19T16:00:00-04:00 2018-04-19T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: Refining Lanthanide Luminescence in Metallacrown Complexes by Systematic Alterations to Aromatic Hyrdroximate Antenna Ligands (April 20, 2018 1:00pm) https://events.umich.edu/event/51459 51459-12112481@events.umich.edu Event Begins: Friday, April 20, 2018 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Jacob C. Lutter (Advisor: Prof. Vincent L. Pecoraro)

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Other Fri, 20 Apr 2018 18:15:18 -0400 2018-04-20T13:00:00-04:00 2018-04-20T14:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: Heme Protein Engineering and Mechanistic Investigations (April 23, 2018 1:00pm) https://events.umich.edu/event/51697 51697-12196745@events.umich.edu Event Begins: Monday, April 23, 2018 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Matthew Wolf (Advisor: Prof. Nicolai Lehnert)

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Other Mon, 23 Apr 2018 18:15:15 -0400 2018-04-23T13:00:00-04:00 2018-04-23T14:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense:Functionality and Functionalization of Metal—Organic Frameworks (April 26, 2018 2:00pm) https://events.umich.edu/event/52016 52016-12354513@events.umich.edu Event Begins: Thursday, April 26, 2018 2:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Jake Boissonnault (Advisor: Prof. Adam Matzger)

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Other Thu, 26 Apr 2018 18:15:20 -0400 2018-04-26T14:00:00-04:00 2018-04-26T15:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: The role of histone acetylation in C. elegans dosage compensation (April 26, 2018 2:30pm) https://events.umich.edu/event/52109 52109-12438405@events.umich.edu Event Begins: Thursday, April 26, 2018 2:30pm
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Csankovszki Lab

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Workshop / Seminar Thu, 26 Apr 2018 10:25:24 -0400 2018-04-26T14:30:00-04:00 2018-04-26T16:00:00-04:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar microscope image stained tissue
Drug Substance Manufacturing Process Development (April 26, 2018 4:00pm) https://events.umich.edu/event/50546 50546-11796687@events.umich.edu Event Begins: Thursday, April 26, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Dr. Seble Wagaw was born in Addis Ababa, Ethiopia, and moved to Ann Arbor with her family in 1974. She carried out her undergraduate studies at the University of Michigan, where she majored in chemistry, and conducted undergraduate research under the supervision of Prof. Will Pearson. Following the completion of her BS Chemistry degree in 1994, she moved to MIT as a Ford Foundation Predoctoral Fellow. She carried out her graduate research in the lab of Prof. Stephen L. Buchwald, where she did pioneering work on the development of palladium-catalyzed aryl carbon-nitrogen bond forming reactions. The transformations she invented are now widely used in both academic and industrial labs across the world, and the papers she published during her graduate studies have been collectively cited over 3100 times. She received her Ph.D. from MIT in 1999, and then began her independent career in Abbott Laboratories’ Global Pharmaceutical Research and Development Division. She has remained at Abbott (now Abbvie) since 1999, and is currently Director of Pharmaceutical Development.












Seble Wagaw (Abbvie)

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Other Thu, 26 Apr 2018 18:15:20 -0400 2018-04-26T16:00:00-04:00 2018-04-26T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: Atmospheric Particle Production from Freshwater and Oceanic Wave-breaking (April 30, 2018 1:00pm) https://events.umich.edu/event/52017 52017-12354514@events.umich.edu Event Begins: Monday, April 30, 2018 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Nate May (Advisor: Prof. Kerri Pratt)

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Other Mon, 30 Apr 2018 18:15:15 -0400 2018-04-30T13:00:00-04:00 2018-04-30T14:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: Chiral Brønsted Acid: Innovations and Application to Site-Selective Glycosylations (May 2, 2018 2:00pm) https://events.umich.edu/event/51698 51698-12196746@events.umich.edu Event Begins: Wednesday, May 2, 2018 2:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Tay (Jia-Hui) Rosenthal (Advisor: Pavel Nagorny)

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Other Wed, 02 May 2018 18:15:23 -0400 2018-05-02T14:00:00-04:00 2018-05-02T15:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: Photochemical Methods for Arene Functionalization (May 3, 2018 2:00pm) https://events.umich.edu/event/52103 52103-12432770@events.umich.edu Event Begins: Thursday, May 3, 2018 2:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Timothy Monos (Advisor: Prof. Corey Stephenson)

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Other Thu, 03 May 2018 18:15:15 -0400 2018-05-03T14:00:00-04:00 2018-05-03T15:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Emerging Directions in the Chemistry of the Rare Earth Elements: Sustainability and Bioinorganic Chemistry (May 7, 2018 4:10am) https://events.umich.edu/event/50433 50433-11739719@events.umich.edu Event Begins: Monday, May 7, 2018 4:10am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The chemistry of rare earth elements (La–Lu, Sc and Y) touches key issues in modern inorganic chemistry including metals criticality, sustainability, and the global carbon cycle. In this talk, I will present on two projects from my research group involving targeted separations chemistry for metals recycling and a new, natural bioinorganic chemistry for the rare earths. Rare earth elements are essential in renewable energies technologies including in permanent magnets for wind turbines, hybrid and electric vehicles, energy efficient lighting phosphors and many others. The rare earths are relatively abundant in the earth’s crust. But the conventional separations chemistry used to purify them proceeds through solvent extraction, a scalable but (stepwise) poorly efficient process that includes an unsustainable environmental burden. We have developed a hydroxylamine ligand, H3TriNOx, and its coordination chemistry. The RE(TriNOx) RE = La–Lu, Y series led to identification of an unusual solubility dependence of the resulting complexes, which afforded a new method for separating rare earth elements, especially for recycling. The TriNOx3– ligand also exhibits redox activity when coordinated to metal cations. We have recently determined that this redox activity can be exploited for metal separations based on variable rates of oxidation. Despite the relatively large abundances of early rare earth elements, it had been widely believed that these elements had no role in biology. Recently, however, a metalloenzyme was discovered that includes cerium, lanthanum and other elements in its active site. This methanol dehydrogenase, Xoxf, catalyzes the conversion of methanol to formaldehyde and, uniquely, to formate. We have developed a tethered quinolone quinone ligand that replicates the structure and function of the active site of the Xoxf metalloenzyme for the first time. We have used this compound to study the reactivity of alcohol dehydrogenation using a benzylic alcohol test substrate. Our results contribute to understanding about why Nature selects for lanthanides in this case and to understanding the reaction mechanism of the Xoxf methanol dehydrogenase.












Eric Schelter (University of Pennsylvania)

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Other Mon, 07 May 2018 18:15:14 -0400 2018-05-07T04:10:00-04:00 2018-05-07T05:10:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: Ultrafast Vibrational Dynamics of Model Catalysts (May 9, 2018 9:00am) https://events.umich.edu/event/52237 52237-12561800@events.umich.edu Event Begins: Wednesday, May 9, 2018 9:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Peter A. Eckert (Advisor: Prof. Kevin Kubarych)

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Other Wed, 09 May 2018 18:15:15 -0400 2018-05-09T09:00:00-04:00 2018-05-09T10:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: Advancing Conjugated Polymer Synthesis Through Catalyst Design (May 11, 2018 1:00pm) https://events.umich.edu/event/52167 52167-12510638@events.umich.edu Event Begins: Friday, May 11, 2018 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Kendra D. Souther (Advisor: Anne J. McNeil)

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Other Fri, 11 May 2018 18:15:15 -0400 2018-05-11T13:00:00-04:00 2018-05-11T14:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Fused Triazoles are P2X7 Antagonists: Synthetic and pre-clinical strategies targeting the treatment of depression (May 14, 2018 4:00pm) https://events.umich.edu/event/51857 51857-12265831@events.umich.edu Event Begins: Monday, May 14, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Current data continues to indicate an important relationship between neuroinflammation and neuropsychiatric disorders. We have explored inhibitors of the P2X7 receptor, a target that resides along a pro-inflammatory cascade and is expressed systemically as well as in the brain. This presentation will focus on the synthesis and characterization of novel 5,6-fused P2X7 antagonists. Highlights include the development of a single pot dipolar cycloaddition reaction / Cope elimination sequence to access 1,4,6,7-tetrahydro-5H-[1,2,3]triazolo[4,5-c]pyridines that contain a synthetically challenging chiral center. The successful implementation of the chemistry has allowed for prompt advancement of candidates to the clinic.








Christa Chrovian (Janssen Research and Development)

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Other Mon, 14 May 2018 18:15:15 -0400 2018-05-14T16:00:00-04:00 2018-05-14T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: Developing Structural Mass Spectrometry Approaches for Therapeutic Antibody Characterization (May 31, 2018 2:00pm) https://events.umich.edu/event/52429 52429-12706749@events.umich.edu Event Begins: Thursday, May 31, 2018 2:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Yuwei Tian (Advisor: Prof. Brandon T. Ruotolo)

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Other Thu, 31 May 2018 18:15:19 -0400 2018-05-31T14:00:00-04:00 2018-05-31T15:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Novartis Symposium (June 5, 2018 2:00pm) https://events.umich.edu/event/52292 52292-12592844@events.umich.edu Event Begins: Tuesday, June 5, 2018 2:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

This presentation will discuss the design concepts of optimizing membrane affinity for inhaled GPCR targeted drug candidates, including novel NMR evidence that demonstrates the specific interaction of molecules with phospholipids, and the structure activity relationship related to these interactions. This has resulted in the discovery of QCC374, the first selective prostacyclin (IP) receptor agonist rationally designed for dry powder inhalation (DPI) for pulmonary arterial hypertension (PAH). Inhaled QCC374 offers high levels of lung exposure, a long duration of action (via optimized cell-membrane affinity) and low systemic exposure (high plasma protein binding, rapid clearance) and is currently in Ph2 trials.

Pulmonary arterial hypertension (PAH) is an orphan disease characterized by chronic elevation in pulmonary arterial pressure, progressive pulmonary remodeling, right heart failure, and mortality. Despite major advances with the development of marketed therapies targeting three pathways: the endothelin, nitric oxide (PDE5 and guanylate cyclase), and prostacyclin pathways, PAH remains a fatal disease with a median survival from diagnosis of 7 years (Benza et al, 2012).

Prostacyclin (IP) analogues confer antiproliferative, vasodilatory, and anti-inflammatory effects. Despite the precedent within this class of approved therapies (epoprostenol, iloprost, treprostinil, beraprost & recently approved oral selexipag), all these agents have significant dose-limiting adverse events (AEs), ranging from headache and jaw pain to nausea/vomiting/diarrhea and hypotension, that significantly impact the safety, tolerability and efficacy of this class. The initiation of prostacyclin therapy is therefore delayed in many PAH patients, with a subsequent negative effect on prognosis (Badagliacca et al 2012).
We believe with optimized membrane affinity and lung duration of action, QCC374 has the attributes to demonstrate a class-leading profile, differentiating from other marketed prostacyclin analogues, with the potential for earlier and broader use across PAH.

Badagliacca, R., et al (2012) Prognostic factors in severe pulmonary hypertension patients who need parenteral prostanoid therapy: the impact of late referral. J Heart Lung Transplant; 31:(4) 364-72.

Benza, R. L., et al (2012) An evaluation of long-term survival from time of diagnosis in pulmonary arterial hypertension from the REVEAL

















Emily Balskus(Harvard University) , Jennifer Prescher(University of California, Irvine) , Mark Healy(Novartis Institutes for Biomedical Research, Cambridge, MA, USA)

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Other Tue, 05 Jun 2018 18:15:21 -0400 2018-06-05T14:00:00-04:00 2018-06-05T18:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: Metal-Organic Frameworks: Post Synthetic Modifications and Applications (June 6, 2018 2:00pm) https://events.umich.edu/event/52450 52450-12745205@events.umich.edu Event Begins: Wednesday, June 6, 2018 2:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Bryant James (Advisor: Prof. Melanie Sanford)

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Other Wed, 06 Jun 2018 18:15:20 -0400 2018-06-06T14:00:00-04:00 2018-06-06T15:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Coordination Chemistry of Paramagnetic “Scorpionate” Complexes As Probed By Spectroscopic and Computational Methods (July 17, 2018 3:30pm) https://events.umich.edu/event/52826 52826-13083861@events.umich.edu Event Begins: Tuesday, July 17, 2018 3:30pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The trispyrazolylborate, scorpionate, ligand (pioneered by the late S. Trofimenko) coordinates almost every type of metal ion (p, d, and f block). More recently, trisimidazolylborate analogs of this ligand (pioneered by J. M. Smith) have led to complexes with interesting structure and reactivity. We will describe the use of spectroscopic techniques, primarily EPR, but also optical spectroscopy, including MCD, to study the electronic structure of several paramagnetic, first row transition metal ion (Mn(III, IV), Fe(II), Co(II), and Ni(II)) complexes supported by scorpionate ligands. For such high-spin (meaning with S > 1/2, in this context) complexes, EPR at high magnetic fields (up to 25 T) and correspondingly high frequencies (sub-THz: 95 ? 750 GHz), known as HFEPR, is especially useful. We will discuss how classical ligand-field theory (LFT), as well as more modern, quantum chemical theory (QCT) methods can be used to provide valuable chemical information on these systems.




















Joshua Telser (Roosevelt University)

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Other Tue, 17 Jul 2018 18:15:17 -0400 2018-07-17T15:30:00-04:00 2018-07-17T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Alum|NUM Pre-Karle Symposium Alumni Event (August 2, 2018 12:00pm) https://events.umich.edu/event/52786 52786-13079502@events.umich.edu Event Begins: Thursday, August 2, 2018 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Alumni Networking at the University of Michigan (Alum|NUM), a half-day event which connects Chemistry Department alumni with current graduate students and post-docs

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Reception / Open House Mon, 02 Jul 2018 09:41:07 -0400 2018-08-02T12:00:00-04:00 2018-08-02T18:00:00-04:00 Chemistry Dow Lab Department of Chemistry Reception / Open House save the date image
Karle Symposium (August 3, 2018 8:00am) https://events.umich.edu/event/52649 52649-12916811@events.umich.edu Event Begins: Friday, August 3, 2018 8:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Learn about the exciting research at Michigan Chemistry through this graduate student organized event -- featuring our talented students as speakers and at poster sessions.

The key note speaker is Prof. Malika Jefferies-EL, Boston University, on "Design and Synthesis of Organic Semiconductors for Advanced Applications".

Also there will be plenary industrial talks by Dow and PPG, who provide travel awards to students. The Dow speaker is Dr. Jodi Mecca on "High Throughput Coatings at Dow: Challenging Paradigms through Experimentation and Fundamental Science" and the PPG speaker is Dr. Steven R. Zawacky who will be speaking on "Making a Greener Catalyst for Electrodeposited Organic Coatings."

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Conference / Symposium Wed, 13 Jun 2018 15:40:51 -0400 2018-08-03T08:00:00-04:00 2018-08-03T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Conference / Symposium logo block with K and 20 18
Necessity is the Mother of Invention: Natural Products and the Chemistry They Inspire (August 10, 2018 3:00pm) https://events.umich.edu/event/47915 47915-11121025@events.umich.edu Event Begins: Friday, August 10, 2018 3:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The chemical synthesis of natural products provides an exciting platform from which to conduct fundamental research in chemistry and biology. Our group is currently pursuing the synthesis of a number of structurally complex natural products, including the diterpenoids ryanodine, talatisamine, and pleuromutilin. The densely-packed arrays of heteroatoms and stereogenic centers that constitute these polycyclic targets challenge the limits of current technology and inspire the development of new synthetic strategies and tactics. This seminar will describe the latest progress in our methodological and target-directed synthesis endeavors.









Sarah Reisman (Caltech)

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Other Tue, 24 Jul 2018 06:15:17 -0400 2018-08-10T15:00:00-04:00 2018-08-10T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: Protein Cross-linking Capillary and Microchip Electrophoresis for Protein- Protein Interaction Analysis (August 17, 2018 3:00pm) https://events.umich.edu/event/53780 53780-13461537@events.umich.edu Event Begins: Friday, August 17, 2018 3:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Claire Ouimet (Advisor: Prof. Robert Kennedy)

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Other Fri, 17 Aug 2018 18:15:39 -0400 2018-08-17T15:00:00-04:00 2018-08-17T16:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: "Towards Automated Epigenetics: Sample Processing with Droplet Microfluidics" (August 20, 2018 9:00am) https://events.umich.edu/event/53781 53781-13461538@events.umich.edu Event Begins: Monday, August 20, 2018 9:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Yi Xu (Advisor: Prof. Ryan C. Bailey)

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Other Mon, 20 Aug 2018 18:15:44 -0400 2018-08-20T09:00:00-04:00 2018-08-20T10:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Innovation by Evolution: Expanding the Enzyme Universe (August 30, 2018 4:00pm) https://events.umich.edu/event/51514 51514-12129616@events.umich.edu Event Begins: Thursday, August 30, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


Not satisfied with nature’s vast enzyme repertoire, we want to create new ones and expand the space of genetically encoded enzyme functions. I will describe how we use the most powerful biological design process, evolution, to optimize existing enzymes and invent new ones. In this first lecture, I will describe different evolutionary strategies that allow us to circumvent our profound ignorance of how sequence encodes function. Mimicking nature’s evolutionary tricks and using a little chemical intuition, we can generate whole new enzyme families that catalyze important reactions, including ones not known in nature, thereby adding new capabilities to the chemistry of the biological world and increasing the scope of molecules and materials we can build.














Frances Arnold (California Institute of Technology)

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Other Thu, 30 Aug 2018 18:15:41 -0400 2018-08-30T16:00:00-04:00 2018-08-30T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Bringing new chemistry to life with laboratory-evolved carbene and nitrene transferases (August 31, 2018 2:00pm) https://events.umich.edu/event/51515 51515-12129617@events.umich.edu Event Begins: Friday, August 31, 2018 2:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry
















Frances Arnold (California Institute of Technology)

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Other Fri, 31 Aug 2018 18:15:40 -0400 2018-08-31T14:00:00-04:00 2018-08-31T15:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
"Adding, removing and measuring cysteine post-translational modifications" (September 5, 2018 4:00pm) https://events.umich.edu/event/54414 54414-13583288@events.umich.edu Event Begins: Wednesday, September 5, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Brent Martin (University of Michigan)

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Other Wed, 05 Sep 2018 18:15:48 -0400 2018-09-05T16:00:00-04:00 2018-09-05T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
UROP Resume Workshop - Wednesday 5-6pm (September 5, 2018 5:00pm) https://events.umich.edu/event/54677 54677-13634088@events.umich.edu Event Begins: Wednesday, September 5, 2018 5:00pm
Location: Chemistry Dow Lab
Organized By: UROP - Undergraduate Research Opportunity Program

This workshop is for UROP students only.
UROP students please register at https://ttc.iss.lsa.umich.edu/undergrad/?s=urop&submit=Search

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Workshop / Seminar Tue, 04 Sep 2018 11:44:39 -0400 2018-09-05T17:00:00-04:00 2018-09-05T18:00:00-04:00 Chemistry Dow Lab UROP - Undergraduate Research Opportunity Program Workshop / Seminar Chemistry Dow Lab
BMS Symposium (September 6, 2018 4:00pm) https://events.umich.edu/event/53782 53782-13461539@events.umich.edu Event Begins: Thursday, September 6, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Society depends on polymeric materials more now than at any other time in history. Although synthetic polymers are indispensable in a diverse array of applications, ranging from commodity packaging and structural materials to technologically complex biomedical and electronic devices, their synthesis and disposal pose important environmental challenges. The focus of our research is the development of sustainable routes to polymers that have reduced environmental impact. This lecture will focus on our research to transition from fossil fuels to renewable resources for polymer synthesis, as well as the development of polymeric materials designed to bring positive benefits to the environment.












Adrian Ortiz(Bristol Myers Squibb) , Geoffrey Coates(Cornell University)

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Other Thu, 06 Sep 2018 18:15:58 -0400 2018-09-06T16:00:00-04:00 2018-09-06T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
UROP Resume Workshop - Thursday 5-6pm (September 6, 2018 5:00pm) https://events.umich.edu/event/54678 54678-13634089@events.umich.edu Event Begins: Thursday, September 6, 2018 5:00pm
Location: Chemistry Dow Lab
Organized By: UROP - Undergraduate Research Opportunity Program

This event is for UROP students only. UROP students please register at https://ttc.iss.lsa.umich.edu/undergrad/?s=urop&submit=Search

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Workshop / Seminar Tue, 04 Sep 2018 11:51:01 -0400 2018-09-06T17:00:00-04:00 2018-09-06T18:00:00-04:00 Chemistry Dow Lab UROP - Undergraduate Research Opportunity Program Workshop / Seminar Chemistry Dow Lab
"Bimolecular Concert at the Cell Membrane Interface" (September 7, 2018 4:00pm) https://events.umich.edu/event/53436 53436-13381405@events.umich.edu Event Begins: Friday, September 7, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Physicochemical and structural properties of molecules at the cell membrane interface are crucial for cellular and other biological functions, and are implicated in numerous diseases including amyloid diseases and bacterial/viral infection. While it is obvious that such properties must be fully characterized for biotechnological and biomedical purposes, the intrinsic complexity of the lipid bilayer environment poses tremendous challenges to most biophysical techniques and biochemical approaches. The Ramamoorthy group has been developing novel membrane mimetics and biophysical (including NMR) approaches to overcome these challenges, and apply them to investigate dynamic structures of membrane proteins and membrane-assisted amyloid aggregation processes. The Biophysical Concert will focus on the following specific topics to highlight the challenges and recent advances:

*Advantages and limitations of "sushi-like" lipid-nanodiscs (Ravula)
*Probing atomic-resolution "hugs and kisses" that enable enzymatic function (Gentry)
*Capturing the amyloid-ghosts red-handed by nanodiscs (Sahoo)
*Atomic-resolution "weed-and-feed" action of amyloid-inhibitors (Cox)

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Workshop / Seminar Thu, 30 Aug 2018 15:05:49 -0400 2018-09-07T16:00:00-04:00 2018-09-07T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
"Catalytic Carbonyl-Olefin Metathesis and Oxygen Atom Transfer" (September 10, 2018 4:00pm) https://events.umich.edu/event/54415 54415-13583289@events.umich.edu Event Begins: Monday, September 10, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Corinna Schindler (University of Michigan)

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Other Mon, 10 Sep 2018 18:15:46 -0400 2018-09-10T16:00:00-04:00 2018-09-10T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Open Lecture | Sounding the deeps of nature: lyric language and the language of oppression (September 11, 2018 3:00pm) https://events.umich.edu/event/54812 54812-13645241@events.umich.edu Event Begins: Tuesday, September 11, 2018 3:00pm
Location: Chemistry Dow Lab
Organized By: LSA Honors Program

Speaker's Notes:
The concept of oppression, just as the concept of freedom, is narrative and operates at the level of words: there is a narrative that accompanies every transaction of meaning taking place between us and the larger forces of the world. This lecture will address the interface between poetry and politics in language, using the reality of oppression in order to probe deeper into the fundamental concept of freedom. Poetry is used as a thinking and a feeling ground on which the language of oppression and lyrical language come into contact, giving us a deeper sense of our human condition. I will argue for the importance of claiming one's inner freedom from the language of oppression that enters the language of poetry.

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Lecture / Discussion Wed, 05 Sep 2018 14:31:08 -0400 2018-09-11T15:00:00-04:00 2018-09-11T16:00:00-04:00 Chemistry Dow Lab LSA Honors Program Lecture / Discussion Carmen Bugan
WISE Sundaes on Tuesday (September 11, 2018 6:30pm) https://events.umich.edu/event/54279 54279-13563515@events.umich.edu Event Begins: Tuesday, September 11, 2018 6:30pm
Location: Chemistry Dow Lab
Organized By: Women in Science and Engineering (WISE) Program

Welcome to the University of Michigan from the UM Women in Science and Engineering (WISE) Program!

Please join WISE for ice-cream sundaes and the inside scoop on how seasoned UM students in sciences, engineering, mathematics, and related concentrations survived their freshman year and beyond!

Find out from our panel of seasoned undergraduate women in science and engineering how they managed it all! Learn about resource centers on campus that are used by science, math, and engineering students. Bring your questions.

This is targeted to incoming first year and transfer students but is open to any interested student!

Please register for this event using this link:
http://ttc.iss.lsa.umich.edu/undergrad/sessions/sundaes-on-tuesday-welcome-for-um-women-interested-in-science-and-engineering-2/

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Workshop / Seminar Mon, 27 Aug 2018 10:49:47 -0400 2018-09-11T18:30:00-04:00 2018-09-11T20:00:00-04:00 Chemistry Dow Lab Women in Science and Engineering (WISE) Program Workshop / Seminar Chemistry Dow Lab
Why the working class needs socialism (September 11, 2018 7:00pm) https://events.umich.edu/event/55025 55025-13671786@events.umich.edu Event Begins: Tuesday, September 11, 2018 7:00pm
Location: Chemistry Dow Lab
Organized By: International Youth and Students for Social Equality

Why the working class needs socialism: The Trump administration, the Democratic Party and the fight for the political independence of the working class

Presentation by Niles Niemuth, socialist candidate for Congress with the Socialist Equality Party.

Tuesday, September 11 from 7PM–9PM
Room 1300 in the Chemistry Building


Ferocious conflicts are pitting the Trump administration against powerful factions of the military-intelligence apparatus, backed by the Democrats. However, these are conflicts between two reactionary factions of the capitalist ruling elite. Trump is seeking to cultivate a fascistic movement to serve as the spearhead for the policies of the financial aristocracy. The Democrats want a more aggressive war policy in the Middle East and against Russia.

There is growing support for socialism among workers and youth, produced by record social inequality, continuous attacks on wages and social programs, and unending war. The fight for socialism means a fight against the capitalist system. It requires the independent mobilization of the working class against the Democrats, the Republicans and the social system they defend.

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Presentation Sat, 08 Sep 2018 17:20:17 -0400 2018-09-11T19:00:00-04:00 2018-09-11T21:00:00-04:00 Chemistry Dow Lab International Youth and Students for Social Equality Presentation Chemistry Dow Lab
Natural product bioactive peptide discovery via PepSAVI-MS (September 13, 2018 4:00pm) https://events.umich.edu/event/53888 53888-13472315@events.umich.edu Event Begins: Thursday, September 13, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

As current methods for antibiotic drug discovery are being outpaced by the rise of antimicrobial resistance, new methods and innovative technologies are crucial to replenish our dwindling arsenal of antimicrobial therapeutics. While natural products are a well-studied source of biologically active small molecules, peptidyl factors contributing to their medicinal properties remain largely unexplored. To this end, we have developed the PepSAVI-MS (Statistically-guided bioactive peptides prioritized via mass spectrometry) pipeline1 to identify bioactive peptide targets from complex biological samples. MS/MS techniques such as CID, ETD, UVPD are implemented for de novo characterization. To validate this pipeline, we have demonstrated successful detection and identification of a known antimicrobial peptide, cycloviolacin O2 (cyO2), from the botanical species Viola odorata. Additionally, we have widened the known antimicrobial spectrum for V. odorata cyclotides, including antibacterial activity of cyO2 against A. baumannii and novel anticancer activities for cycloviolacins by their cytotoxicity against ovarian, breast and prostate cancer cell lines. The developed platform is highly versatile as it is adaptable to any natural product source of peptides and can test against diverse physiological targets, including bacteria, fungi, viruses, protozoans, and cancer cells for which there is a developed bioassay. As such, we demonstrate extension of this pipeline to fungal and bacterially-sourced AMPs through the identification of the killer toxin KP4 from Ustilago maydis2 and the bacteriocin Bac-21 from Enterococcus faecalis harboring pPD1. Bac-21 is identical in nucleotide sequence to another enterococcal bacteriocin, AS-48, but we have experimentally validated the protein sequence of Bac-21 for the first time. Additionally, we begin to probe the vast array of botanical natural product sources to prioritize highly active species for downstream analysis.
















Leslie Hicks (The University of North Carolina at Chapel Hill)

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Other Wed, 12 Sep 2018 12:15:52 -0400 2018-09-13T16:00:00-04:00 2018-09-13T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: "Magnetic Resonance Studies of Membrane Proteins" (September 14, 2018 4:00pm) https://events.umich.edu/event/53437 53437-13381406@events.umich.edu Event Begins: Friday, September 14, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: CW and pulsed Electron Paramagnetic Resonance (EPR) spectroscopic techniques coupled with site-directed spin-labeling (SDSL) can provide important structural information on complicated biological systems such as membrane proteins. Strategically placed spin-labels alter relaxation times of NMR active nuclei and yield pertinent structural information. EPR techniques such as Double Electron-Electron Resonance (DEER) and Electron Spin Echo Envelope Modulation (ESEEM) are powerful structural biology tools. The DEER technique can be used to measure distances between 2 spin labels from 20 to 70 Å. However, the application of DEER spectroscopy to study membrane proteins can be difficult due to short phase memory times (Tm) and weak DEER modulation in more biologically relevant proteoliposomes when compared to water soluble proteins or membrane proteins in detergent micelles. The combination of these factors often leads to broad distance distributions, poor signal to noise, and limitations in the determination of longer distances. The short phase memory times are typically due to uneven distributions of spin-labeled protein within the lipid bilayer, which creates local inhomogeneous pockets of high spin concentrations. Approaches to overcome these limitations and improve the quality of DEER measurements for membrane proteins will be discussed: lipodisq nanoparticles, bi-functional spin labels (BSL), and Q-band pulsed EPR spectroscopy. ESEEM data will be shown to probe the secondary structure of membrane proteins. CW-EPR spectra of spin-labeled membrane proteins will be used to investigate dynamics and the immersion depth in a lipid bilayer.

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Workshop / Seminar Thu, 30 Aug 2018 16:29:54 -0400 2018-09-14T16:00:00-04:00 2018-09-14T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Gary Lorigan
Ultrafast tabletop XUV spectroscopy of transition metal complexes and organohalide perovskites (September 20, 2018 4:00pm) https://events.umich.edu/event/52759 52759-13021395@events.umich.edu Event Begins: Thursday, September 20, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

X-ray absorption near edge spectroscopy (XANES or NEXAFS) is a powerful technique for electronic structure determination. However, widespread use of XANES is limited by the need for synchrotron light sources with tunable x-ray energy. Recent developments in extreme ultraviolet (XUV) light sources using the laser-based technique of high-harmonic generation have enabled core-level spectroscopy to be performed on femtosecond to attosecond timescales. We have extended the scope of tabletop XUV spectroscopy and demonstrated that M2,3-edge XANES, corresponding to 3p→3d transitions, can reliably measure the electronic structure of first-row transition metal coordination complexes with femtosecond time resolution. We use this ability to track the excited-state relaxation pathways of photocatalysts and spin crossover complexes. In semiconductors such as CH3NH3PbI3, distinct signals are observed for photoinduced electrons and holes, allowing the dynamics of each carrier to be tracked independently. This work establishes high-harmonic spectroscopy as a useful tool for mainstream research in inorganic, organometallic, and materials chemistry.
















Josh Vura-Weis (University of Illinois)

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Other Thu, 20 Sep 2018 12:15:46 -0400 2018-09-20T16:00:00-04:00 2018-09-20T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Exploring and Exploiting the Pentatricopeptide Repeat Proteins: Programmable RNA-Binding Proteins that Emerged Through Nuclear-Organellar Coevolution (September 21, 2018 11:30am) https://events.umich.edu/event/54044 54044-13519623@events.umich.edu Event Begins: Friday, September 21, 2018 11:30am
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Andrzej Wierzbicki

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Workshop / Seminar Wed, 22 Aug 2018 09:41:18 -0400 2018-09-21T11:30:00-04:00 2018-09-21T12:30:00-04:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar cartoon of RNA remodeling
Nanoparticles Meet Biological Membranes: Probing Interaction Using Molecular Simulations (September 21, 2018 4:00pm) https://events.umich.edu/event/53428 53428-13381397@events.umich.edu Event Begins: Friday, September 21, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract:
Over the past decade, with advances in high-performance computing and data science, theory,
simulation, and computation continue to partner with experiment in discovery and innovation in
nanoscience and nanotechnology. Some of the most exciting applications are in the field of biomedicine. Indeed, a detailed understanding of the molecular details of interactions between nanoparticles and biological nanosystems, such as membranes or macromolecules is crucial for obtaining adequate information on mechanisms of action of nanomaterials as well as a perspective on the long-term effects of these materials and their possible toxicological outcomes. In this talk I will report on a new model that we are developing to understand and to predict the interactions between carbon-based nanomaterials and biological membranes using structure-based computational molecular modeling. A rationale on how nanoparticles of different sizes, shape, structure and chemical properties can affect the organization of cellular membranes is also presented. This critical information will help enable the “safe-by-design” production of engineered nanoparticles that are nontoxic or biocompatible, and also allow for the design of antimicrobial nanoparticles for environmental and biomedical applications.

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Workshop / Seminar Fri, 21 Sep 2018 10:31:41 -0400 2018-09-21T16:00:00-04:00 2018-09-21T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
RNA as a Drug Target and Material for Nanotechnology (September 24, 2018 4:00pm) https://events.umich.edu/event/51011 51011-11941993@events.umich.edu Event Begins: Monday, September 24, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Research in the Hermann lab is focused on exploring the structure, molecular recognition and assembly of ribonucleic acid (RNA) architectures.
One key goal is the development of therapies targeting noncoding RNA (ncRNA). ncRNAs participate as key players in many biological processes and may adopt complex folds that are required for function. The development of ligands that bind selectively to ncRNA targets opens new ways to expand the existing repertoire of protein-directed therapeutics. I will present our research on the discovery of an unprecedented molecular switch target in the genome of RNA viruses including the human pathogen hepatitis C virus (HCV) and the development of ligands that inhibit the viral switch.
In the second part of the presentation, I will outline how we use RNA crystal structures to design nano-architectures that self-assemble from small RNA motifs and may serve as combinatorial platforms for applications in molecular recognition, sensor and catalyst development as well as protein interaction studies.












Thomas Hermann (University of California, San Diego)

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Other Mon, 24 Sep 2018 18:15:45 -0400 2018-09-24T16:00:00-04:00 2018-09-24T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Open Lecture | Writing in-between languages: poetry in a second language (September 25, 2018 3:00pm) https://events.umich.edu/event/54814 54814-13645242@events.umich.edu Event Begins: Tuesday, September 25, 2018 3:00pm
Location: Chemistry Dow Lab
Organized By: LSA Honors Program

When the native language becomes unstable, and writers are forced to abandon it, or when experience simply destroys the transaction of meaning or truth between a writer and her language, the notion of the “place of writing” itself becomes destabilized and abstracted. This lecture probes the poet's relationship with an adopted language, acknowledging losses and gains, and offers a glimpse into the experience of writing in-between languages, hovering at the borders between them.

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Lecture / Discussion Wed, 05 Sep 2018 14:34:57 -0400 2018-09-25T15:00:00-04:00 2018-09-25T16:00:00-04:00 Chemistry Dow Lab LSA Honors Program Lecture / Discussion Carmen Bugan
Multi-scale chemistry: From molecular to microsystems (September 27, 2018 4:00pm) https://events.umich.edu/event/53783 53783-13461540@events.umich.edu Event Begins: Thursday, September 27, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The design and manipulation of molecules and chemical reactions offers the possibility for the engineering of materials and devices at multiple length scales from the molecular to the nano, micro, and macro. By way of several examples, this seminar will highlight how chemistry can be used across length scales to create programmable materials, 3D biosensors, and physiologically responsive robots.























David Gracias (Johns Hopkins University)

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Other Thu, 27 Sep 2018 18:15:50 -0400 2018-09-27T16:00:00-04:00 2018-09-27T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Folded Viral RNAs that Sense and Manipulate the Host Cell Machinery: Windows to RNA Structure-Based Regulation (September 28, 2018 4:00pm) https://events.umich.edu/event/53429 53429-13381398@events.umich.edu Event Begins: Friday, September 28, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: RNA is perhaps the most functionally diverse biological macromolecule, due in large part to its ability to adopt a wide range of conformationally dynamic structures. The Kieft Lab is interested in understanding how RNA can adopt diverse three-dimensional folds, how those folds give rise to its many biological roles, and how conformational changes confer RNA’s ability to regulate so many processes. We are particularly interested in viral RNAs, which are fine-tuned by evolution to elegantly and powerfully interact with and manipulate the cellular machinery of the host cell; these viral RNAs provide a “window” into the greater RNA world. In this presentation, I will present some of our recent findings in regard to a viral RNA that adopts an unexpected tertiary structure. This RNA element undergoes programmed conformational changes that are triggered by its interactions with the host cell machinery and this is responsible for its unique function. This RNA may be a paradigm for novel modes of regulation linked to dynamic RNA conformational changes.

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Workshop / Seminar Wed, 26 Sep 2018 14:41:29 -0400 2018-09-28T16:00:00-04:00 2018-09-28T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Jeffrey Kieft
2018 Organic Reactions Symposium (October 1, 2018 1:00pm) https://events.umich.edu/event/50748 50748-11861929@events.umich.edu Event Begins: Monday, October 1, 2018 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

We recently explored the possibility of using gold(I) catalysts to activate allenes towards alcohol nucleophiles to effect allenoate Claisen rearrangements. However, instead of allene activation, a pendant ester was transesterified and etherified, which led to our development of a gold-catalyzed, microwave protocol to activate alcohols to form ethers and amines via an intermolecular, SN1-type reaction. Ultimately, in lieu of a metal-catalyzed version, we have developed a Bronsted acid-catalyzed allenoate Claisen that affords the corresponding products in high yields and enantioselectivities. Lessons learned from these studies have led to the serendipitous discovery of a silver-catalyzed, N-formylation reaction and have informed our development of an anti-Markovnikov hydroamination reaction.








Scott Denmark(University of Illinois) , Noah Burns(Stanford University) , Anna Wenzel(Claremont McKenna College)

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Other Mon, 01 Oct 2018 18:15:51 -0400 2018-10-01T13:00:00-04:00 2018-10-01T18:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Open Lecture | Artistic distance and the language of oppression (October 2, 2018 3:00pm) https://events.umich.edu/event/54817 54817-13645249@events.umich.edu Event Begins: Tuesday, October 2, 2018 3:00pm
Location: Chemistry Dow Lab
Organized By: LSA Honors Program

Writing is an emotional process and it works when it makes us feel, both as writers and readers. Yet a certain emotional distance is necessary when one writes poetry with the language of oppression, especially when one has been the victim, and offers a historical testimony. What kind of liberties can one take with the material? What constitutes appropriate artistic utterance when one navigate the territories of poetry about the hard truths? Rescuing words from screams of pain and anger into poetic expression, which shows the effect of oppression on the inner landscape of feeling, is what poetry offers as an art.

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Lecture / Discussion Wed, 05 Sep 2018 14:38:46 -0400 2018-10-02T15:00:00-04:00 2018-10-02T16:00:00-04:00 Chemistry Dow Lab LSA Honors Program Lecture / Discussion Carmen Bugan
Insights into Complex Molecular Processes from Quantitative Atomistic Simulations (October 2, 2018 4:00pm) https://events.umich.edu/event/52807 52807-13081672@events.umich.edu Event Begins: Tuesday, October 2, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Molecular dynamics simulations are a powerful means to provide
molecular-level insights into processes ranging from gas-phase
reaction dynamics to complex non-reactive and reactive rearrangements
in biological systems. The utility of such simulations depends
sensitively on the accuracy with which the intermolecular interactions
are represented. In this seminar I will discuss recent progress in
force field development including multipolar force fields, reproducing
kernel Hilbert space techniques and machine learning and their
application to spectroscopy and reactive processes in the condensed
phase. The focus is on directly linking experimental observations with
computations which provides molecular level understanding of
spectroscopic observables and time scales from state-of-the art
experiments. A typical example discussed will be the relationship
between structure and dynamics for infrared and X-ray absorption
spectroscopy of biomolecules or the thermodynamics of reversed phase
liquid chromatography.
















Markus Meuwly (University of Basel, Switzerland)

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Other Tue, 02 Oct 2018 18:15:46 -0400 2018-10-02T16:00:00-04:00 2018-10-02T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
2018 Ta-You Wu Lecture in Physics | Topological Quantum Matter, Entanglement, and a "Second Quantum Revolution" (October 3, 2018 4:10pm) https://events.umich.edu/event/53581 53581-13410079@events.umich.edu Event Begins: Wednesday, October 3, 2018 4:10pm
Location: Chemistry Dow Lab
Organized By: Department of Physics

While the laws of quantum mechanics have remained unchanged and have passed all tests for the last eighty-five years, new discoveries about the exotic states that they allow, “entanglement”, and ideas from quantum information theory, have greatly changed our perspective, and some believe that a “second quantum revolution” is currently underway. The discovery of unexpected “topological states of matter”, and their possible use for “topologically-protected quantum information processing” is one of the important themes of these developments, and will be described.

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Lecture / Discussion Tue, 23 Oct 2018 17:03:27 -0400 2018-10-03T16:10:00-04:00 2018-10-03T17:10:00-04:00 Chemistry Dow Lab Department of Physics Lecture / Discussion Chemistry Dow Lab
Exploring Indoor Chemistry: Criegees, Chlorohydrins, and Nitrous Acid (October 4, 2018 4:00pm) https://events.umich.edu/event/52146 52146-12477549@events.umich.edu Event Begins: Thursday, October 4, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The chemical interactions that proceed indoors have not been as well studied as those that occur in outdoor environments. Rather, indoors, focus has primarily been given to emissions from building materials and effects of ventilation. However, it is known that oxidative and partitioning processes occur on most indoor surfaces that affect the chemical exposure that we all experience. Indeed, the concentrations of many chemical species are higher indoors than outdoors. This talk will present examples of indoor oxidative processes that arise via ozone, which is introduced by intake of outdoor air, and via cleaning agents, such as chlorine bleach. Highly reactive surfaces indoors include human skin oils and cooking emissions, and particular attention will be given to the ozonolysis products formed from Criegee intermediates. The nature of non-reactive partitioning in indoor species will also be examined. In particular, new field measurements indicate that molecules that are normally viewed as being highly reactive, such as nitrous acid, are sorbed to indoor surfaces in significant amounts.








Jonathan Abbatt (University of Toronto)

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Other Thu, 04 Oct 2018 18:15:51 -0400 2018-10-04T16:00:00-04:00 2018-10-04T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Analytical 3rd Year Student Seminars (October 5, 2018 4:00pm) https://events.umich.edu/event/54982 54982-13662978@events.umich.edu Event Begins: Friday, October 5, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Megan Connor(Shultz Lab) , Matt Sorensen(Kennedy Lab)

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Other Fri, 05 Oct 2018 18:15:49 -0400 2018-10-05T16:00:00-04:00 2018-10-05T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: "Functional approaches to understanding the development of the Small Multidrug Resistance family of transporters"- Chris Macdonald and "The effect of disruption of synaptic signaling on brain networks" - Maral Budak (October 5, 2018 4:00pm) https://events.umich.edu/event/53431 53431-13381399@events.umich.edu Event Begins: Friday, October 5, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract:
Chris Macdonald - The Small Multidrug Resistance (SMR) family of prokaryotic and archaean proton-coupled transporters provides a window into the evolutionary events that generated the molecular diversity of membrane protein function today. These small 4-pass integral membrane proteins assemble into functional dimers with an unusual antiparallel architecture. The most well-studied example, EmrE, is a homodimeric member that provides resistance to a broad range of hydrophobic cationic aromatic compounds. This talk will cover recent work in the Stockbridge lab that has fundamentally altered our understanding of this family, including functional characterization through flux measurements and solid-supported membrane (SSM) electrophysiology, in vivo metabolic assays, and phylogenetic analysis. We suggest an evolutionary trajectory for the development of new functions in these small proteins.

and

Maral Budak -The information transmission between neurons and brain regions occurs via synapses. Therefore, disruption of synaptic signaling (e.g. synaptic failure or desynchronization of spikes) may have devastating outcomes, such as loss of consciousness or neurodegenerative diseases. First, our objective is understanding the effect of synaptic failure on functional connectivity of different network structures, and we observed that synaptic failure does not always decrease the coherence of neuronal networks, but sometimes promotes the formation of coherent states of activity in the networks. Next, we aim to understand the mechanism of hidden hearing loss caused by myelinopathy. Recently, it’s been hypothesized that disruption of myelination patterns at auditory nerves (AN) causes desynchronization of AN spiking activity. To test this hypothesis, we constructed a reduced biophysical model for a population of inner hair cells with postsynaptic auditory nerve fibers. As a result, our model confirms that heminodal disruption causes desynchronization of AN spikes leading to a loss of temporal resolution.

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Workshop / Seminar Mon, 01 Oct 2018 11:59:37 -0400 2018-10-05T16:00:00-04:00 2018-10-05T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
Nitric Oxide Signaling: From Prokaryotes to Humans (October 8, 2018 4:00pm) https://events.umich.edu/event/50775 50775-11864796@events.umich.edu Event Begins: Monday, October 8, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Nitric oxide (NO) has long been known to be an intermediate in bacterial pathways of denitrification. It is only since the middle to late 1980s that it was found to play a central role in a much broader biology context. For example, it is now well established that NO acts as a signaling agent in higher organisms. Yet NO is toxic and reactive under biological conditions. How is the biology carried out by NO controlled? How is NO used and the inherent toxicity avoided? How do organisms tell the difference between NO and O2? What is the biological output? A molecular perspective on ligand discrimination in hemoproteins has emerged as has a further understanding and predictions about selective ligand sensing and function in biology.














Michael Marletta (University of Berkeley)

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Other Mon, 08 Oct 2018 18:15:47 -0400 2018-10-08T16:00:00-04:00 2018-10-08T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Nandini Ananth: Charge Transfer Dynamics, Excited State Energetics, and Organic Photovoltaics (October 9, 2018 4:00pm) https://events.umich.edu/event/56196 56196-13860237@events.umich.edu Event Begins: Tuesday, October 9, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Michigan Institute for Computational Discovery and Engineering

Designing molecular materials for use as organic photovoltaics, molecular electronics, and photocatalysts is a multifaceted challenge requiring a detailed understanding of both the excited state energetics and the dynamics of charge and energy transfer. We address the dynamic challenge by developing new methods based on the path integral formulation of quantum mechanics that are uniquely suited to the simulation of photo-initiated excited state dynamics in the condensed phase. We then tackle the characterization of the excited state manifold in molecular systems using a combination of high-level electronic structure methods to accurately calculate excited state energies, normal mode analysis to quantify vibronic couplings, and novel orbital analyses to uncover structure-spectrum correlations.
In this talk, we focus on one target application: designing chromophores that exhibit ultrafast Singlet Fission (SF), a phenomenon that has the potential to significantly increase organic solar cell efficiency. We investigate SF in non-bonded and covalently bonded pentacene dimers: we uncover two distinct mechanistic pathways for ultrafast SF and we identify molecular geometries and bonding motifs that can be modified to enhance efficiency in each case. Finally, we combine the insights obtained from our theoretical investigations to generate a priori design principles for next-generation SF chromophores, and working with experimental collaborators, we verify them.

Nandini Ananth is an associate professor in the department of Chemistry and Chemical Biology at Cornell University. She received her bachelor's degree in Chemistry from Stella Maris College in Chennai, India, and a Masters in chemistry from the Indian Institute of Technology Madras.

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Workshop / Seminar Sun, 30 Sep 2018 15:14:35 -0400 2018-10-09T16:00:00-04:00 2018-10-09T17:00:00-04:00 Chemistry Dow Lab Michigan Institute for Computational Discovery and Engineering Workshop / Seminar Ananth
Watching metalloenzymes at work (October 9, 2018 4:00pm) https://events.umich.edu/event/53784 53784-13461541@events.umich.edu Event Begins: Tuesday, October 9, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Structures of bioinorganic catalysts can often uniquely rationalize important aspects of chemical and biological reaction control. My research group studies the structural differences between members of large metalloenzyme superfamilies that share common characteristics but trigger different reactions or use distinct cofactors. We have initially focused on systems unified in their ability to activate strong C-H, N-H, or O-H bonds. Key objectives include identification of the outcome-dictating structural features of a given catalyst and structure-guided reprogramming for new function. To achieve these ends, we determine stable reactant and product complexes, with an increasing focus on development and implementation of crystallographic approaches to study metalloenzyme reaction intermediates. These experiments are challenging due to the fleeting and reactive nature of these states but uniquely informative because of the fully contextualized view they provide at critical points in the catalytic cycle.












Amie Boal (The Pennsylvania State University)

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Other Tue, 09 Oct 2018 18:15:46 -0400 2018-10-09T16:00:00-04:00 2018-10-09T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Analytical 3rd Year Student Seminars (October 10, 2018 4:00pm) https://events.umich.edu/event/54983 54983-13662979@events.umich.edu Event Begins: Wednesday, October 10, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry








Nicole Olson(Ault Lab) , Daniel Vallejo(Ruotolo Lab)

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Other Wed, 10 Oct 2018 18:15:47 -0400 2018-10-10T16:00:00-04:00 2018-10-10T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Quantum Coherence in Chemistry: Tackling the Decoherence Challenge (October 11, 2018 4:00am) https://events.umich.edu/event/52043 52043-12376521@events.umich.edu Event Begins: Thursday, October 11, 2018 4:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

A subject of considerable current interest in Chemistry is the possibility of using non-trivial quantum mechanical effects, such as coherence and interference, to enhance molecular function. This possibility is hindered by decoherence processes that prevent matter from fully exhibiting its quantum features. In this talk, I will summarize our progress understanding decoherence in molecular processes, and in particular electronic decoherence. I will discuss the basic mechanisms for electronic coherence loss, methods to quantify the decoherence, and a general theory of decoherence timescales. The talk with conclude with some novel prospects on the possibility of using lasers to control electronic decoherence in molecules.






Ignacio Franco (University of Rochester)

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Other Thu, 11 Oct 2018 18:15:53 -0400 2018-10-11T04:00:00-04:00 2018-10-11T05:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Analytical 3rd Year Student Seminars (October 12, 2018 4:00pm) https://events.umich.edu/event/54984 54984-13662980@events.umich.edu Event Begins: Friday, October 12, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry








Kunal Khanna(Walter Lab) , Shane Wells(Kennedy Lab)

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Other Fri, 12 Oct 2018 18:15:50 -0400 2018-10-12T16:00:00-04:00 2018-10-12T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: "Carbonaceous nanoparticle and biological membrane - a molecular dynamic perspective" (October 12, 2018 4:00pm) https://events.umich.edu/event/53433 53433-13381402@events.umich.edu Event Begins: Friday, October 12, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: Nanoparticles have been widely utilized in many health-related fields, such as drug delivery, cancer therapy, biolabeling, and biosensors. Studies on the molecular details of the interaction between nanoparticles and biological nanosystems are crucial for obtaining information on the mechanisms of the possible outcomes of these nanomaterials, such as cytotoxicity, biological accumulation, and long-term effects. In this talk, we will introduce a recent model that we are developing to help understand and predict the interaction between carbonaceous nanoparticles and biological membrane based on the molecular structural information. The model presents in detail how molecular properties of nanoparticles such as size, shape and chemical properties affect the organization of the nanoparticles in the membrane, as well how different components in the membrane affect the selectivity on nanoparticles. This critical information is helpful for designing engineered nanoparticles that are biocompatible, bioavailable for different environmental and biological applications.

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Workshop / Seminar Fri, 28 Sep 2018 11:27:26 -0400 2018-10-12T16:00:00-04:00 2018-10-12T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Desmond Liu
Moving beyond Methionine Synthase: New Insights into Cobalamin-Dependent Methyltransferase Reactions (October 15, 2018 4:00pm) https://events.umich.edu/event/51068 51068-11953412@events.umich.edu Event Begins: Monday, October 15, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Biological methylation underpins myriad cellular processes through the modification of proteins, lipids, nucleic acids, heavy metals, and a variety of small organic molecules. In the vast majority of these reactions, the appended methyl group derives from S-adenosylmethionine (SAM) and is attached most often to nitrogen and oxygen nucleophiles through a polar SN2 mechanism, although carbon, sulfur, and a variety of other nucleophilic atoms also receive SAM-derived methyl groups. Recently, it has become apparent that SAM is used to methylate non-reactive carbon and phosphorus atoms by mechanisms involving radical intermediates. To date, these reactions are catalyzed exclusively by radical SAM enzymes, a superfamily of enzymes that use an iron-sulfur (Fe-S) cluster to catalyze a reductive cleavage of SAM to methionine and the potent oxidant 5’-deoxyadenosin 5’-radical (5’-dA•). There are at least five subclasses of radical SAM methylases. Class B methylases represent the largest subclass, and use cobalamin to methylate both sp2- and sp3-hybridized carbon centers or phosphinate phosphorus centers during the biosynthesis of numerous biomolecules, including natural products with antibiotic and anticancer activities. This lecture will focus on two Class B radical SAM methylases involved in the biosynthesis of antibacterial agents. Fom3, which performs a key step in the biosynthesis of the broad-spectrum antibiotic fosfomycin, catalyzes the methylation of the sp3-hybridized C2’’ carbon of cytidylyl-2-hydroxyethylphosphonate to yield cytidylyl-2-hydroxypropylphosphonate. By contrast, TsrM catalyzes the first committed step in the biosynthesis of the quinaldic acid moiety of the thiopeptide antibiotic thiostrepton, which is the methylation of the sp2-hybridized C2 carbon of the indole ring of L-tryptophan. As will be discussed, while both Fom3 and TsrM are cobalamin-dependent radical SAM methylases, they use two distinctly different strategies to catalyze their reactions.














Squire Booker (The Pennsylvania State University)

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Other Mon, 15 Oct 2018 18:15:46 -0400 2018-10-15T16:00:00-04:00 2018-10-15T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Understanding spliceosome mechanism with small molecule inhibitors (October 16, 2018 4:00pm) https://events.umich.edu/event/51622 51622-12173406@events.umich.edu Event Begins: Tuesday, October 16, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The spliceosome is the cellular machinery responsible for removing introns from gene transcripts by the process of splicing, and a variety of cancers accumulate specific mutations that alter spliceosome activity. In particular, the spliceosome protein SF3B1, which helps identify the boundary of introns, is frequently mutated in hematologic cancers. Notably, SF3B1 is also the common target of several bacterial natural products that were first identified in screens for drugs that kill cancer cells. We are investigating the structure-activity relationships of three different classes of SF3B1 inhibitors. Some analogs that are inactive for splicing inhibition nevertheless compete with their active counterparts, which suggests that drug binding alone is not sufficient to interfere with splicing. Furthermore, the competition of inactive and active compounds holds between different classes of inhibitors, supporting shared pharmacophores. We are now using these compounds as tools to explore the role of SF3B1 in splice site identification and fidelity, as well as in structural transitions required for spliceosome assembly.












Melissa Jurica (UC Santa Cruz)

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Other Tue, 16 Oct 2018 18:15:46 -0400 2018-10-16T16:00:00-04:00 2018-10-16T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Analytical 3rd Year Student Seminars (October 17, 2018 4:00pm) https://events.umich.edu/event/54985 54985-13662981@events.umich.edu Event Begins: Wednesday, October 17, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Colleen Riordan(Bailey Lab) , Shannon Wetzler(Bailey Lab)

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Other Wed, 17 Oct 2018 18:15:47 -0400 2018-10-17T16:00:00-04:00 2018-10-17T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Converting Anti-Aromatic to Aromatic: A Method to Access Boron-Containing Heteroarenes (October 18, 2018 12:00pm) https://events.umich.edu/event/55724 55724-13777498@events.umich.edu Event Begins: Thursday, October 18, 2018 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The concept of inorganic doping by substituting boron and a lone-pair bearing heteroatom in place of a C=C unit in carbon-based aromatics is an attractive method to alter the electronic properties. Our group has been working on developing a facile route to access inorganic/organic hybrid aromatic species via ring insertion reactions with anti-aromatic BC4 heterocycles, namely boroles. The insertion chemistry has been effective for the preparation of 1,2-azaborine, 1,2-phoaphaborine, 1,2-oxaborine, and 1,2-thiaborine heteroarenes which all have lower band gaps, red-shifted absorbances, and larger dipole moments in comparison to their carbonaceous counterpart, benzene. Ongoing efforts are focused on enhancing the electronic properties of these boracycles to explore their utility in electronic materials. Our current strategy is to extend conjugation in the inorganic/organic hybrid arenes by utilizing borole-based starting materials with conjugation installed. The mechanisms of these reactions and properties of the boracycles will be discussed.






Caleb Martin (Baylor University)

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Other Thu, 18 Oct 2018 18:15:47 -0400 2018-10-18T12:00:00-04:00 2018-10-18T13:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
EEB Thursday Seminar: Trait-based approaches to plankton ecology & evolution (October 18, 2018 12:00pm) https://events.umich.edu/event/49651 49651-11487536@events.umich.edu Event Begins: Thursday, October 18, 2018 12:00pm
Location: Chemistry Dow Lab
Organized By: Ecology and Evolutionary Biology

NOTE TIME & LOCATION CHANGE

Abstract
Trait-based approaches are increasingly seen as a way to reduce the complexity of ecological communities and to incorporate functional diversity in ecosystem models. In this talk I will present Elena Litchman's and my lab's work applying trait-based ideas to marine and freshwater plankton communities. First, I will describe empirical patterns in the resource utilization and thermal traits we found using meta-analyses of published eco-physiological traits. Second, I will discuss trait-based approaches to modeling ecological and eco-evolutionary dynamics and how they can enhance our understanding of community structure in heterogeneous environments. Finally, I will describe recent theory on how local selection and immigration from the regional species pool interact to determine distribution of commonness and rarity in ecological communities and an experimental test.

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Lecture / Discussion Fri, 12 Oct 2018 09:38:16 -0400 2018-10-18T12:00:00-04:00 2018-10-18T13:00:00-04:00 Chemistry Dow Lab Ecology and Evolutionary Biology Lecture / Discussion graph of space, time and trait
"Development of New Catalytic Reactions Involving the Activation of Traditionally Inert Bonds" (October 19, 2018 4:00pm) https://events.umich.edu/event/52879 52879-13094886@events.umich.edu Event Begins: Friday, October 19, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Organic molecules contain a variety of chemical bonds. Organic synthesis involves the cleavage of a chemical bond and the formation of a new chemical bond. However, not all of the chemical bonds in organic molecules have been used in organic synthesis. Thus, organic synthesis is heavily dependent on the reactivity of chemical bonds. If so-called unreactive bonds were to be used directly in organic synthesis, new possibilities for developing new synthetic methodologies would arise. We have utilized, not only the activation of C-H bonds, but also the activation of unreactive single bonds, such as C-C, C-O, C-N, and C-F bonds, and the activation of C-C triple bonds and C-O double bonds, in our quest to develop new types of transformations that will lead to further diversification in the field of organic synthesis.
















Naoto Chatani (Osaka University)

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Other Fri, 19 Oct 2018 18:15:48 -0400 2018-10-19T16:00:00-04:00 2018-10-19T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: “Protons to patients: evaluating the role of the chloride transporter ClC-7 in lysosomal function” (October 19, 2018 4:00pm) https://events.umich.edu/event/53434 53434-13381403@events.umich.edu Event Begins: Friday, October 19, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: Lysosomes are essential focal points of cellular metabolism, digesting a wide range of macromolecules provided by endocytosis or autophagy. To this end, lysosomes rely on their highly acidic luminal pH to promote the function of their many enzymes, a pH generated by the action of a v-Type proton pumping ATPase. Since this transporter is electrogenic, parallel ion movements must occur to dissipate the generated membrane potential and promote bulk proton flux. I will present evidence that the Cl-/H+ antiporter, ClC-7, plays this role, moving Cl- to dissipate the lysosomal transmembrane voltage. However, the function of ClC-7 has been controversial, with conflicting reports on its contribution to lysosomal acidification. All heretofore known patients with ClC-7 functional mutations have varying degrees of the same disease, with osteopetrosis sometimes associated with lysosomal storage disease. Here, we report on two patients with a novel disease manifested as widespread lysosomal dysfunction but no bone abnormalities, who both have the same missense mutation in ClC-7. We find that fibroblasts from both patients have acidification abnormalities and that heterologously expressed human ClC-7 carrying this mutation displays a novel phenotype under electrophysiological measurements. These findings provide strong support for an important role of ClC-7 in the lysosomal acidification process and suggest opportunities for therapies for these patients.

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Workshop / Seminar Wed, 26 Sep 2018 15:30:54 -0400 2018-10-19T16:00:00-04:00 2018-10-19T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Joe Mindell
GSK Info Session (October 22, 2018 11:15am) https://events.umich.edu/event/56687 56687-13963071@events.umich.edu Event Begins: Monday, October 22, 2018 11:15am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Beth Knapp-Reed, PhD

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Workshop / Seminar Mon, 22 Oct 2018 18:15:46 -0400 2018-10-22T11:15:00-04:00 2018-10-22T12:15:00-04:00 Chemistry Dow Lab Department of Chemistry Workshop / Seminar Chemistry Dow Lab
Ozone, Carbon Dioxide, and Unusual Kinetic Isotope Effects: From the Stratosphere to the Laboratory and Back Again (October 22, 2018 4:00pm) https://events.umich.edu/event/53008 53008-13181201@events.umich.edu Event Begins: Monday, October 22, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The discovery of unusual oxygen isotope compositions in ozone and carbon dioxide by Mauersberger and co-workers and Thiemens and co-workers in the 1980s and 1990s has been followed by the challenges of understanding the chemical physics of the non-standard kinetic isotope effects on a molecular level and how they play out on a global scale, with the promise of providing new isotopic tracers of ozone production and transport in the stratosphere and the rates of uptake of atmospheric carbon dioxide by the biosphere. In this talk, I will highlight laboratory experiments (including crossed molecular beam experiments on O+O2 and O+CO2 and bulk photochemistry experiments on CO2 and O2 mixtures) and new stratospheric isotope measurements on air collected by aircraft and balloon flights that provide new insight into and constraints on the chemical physics of these unusual isotope effects needed to support their growing application to solving problems in the Earth and environmental sciences across a variety of disciplines.










Kristie Boering (University of California Berkeley)

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Other Mon, 22 Oct 2018 18:15:46 -0400 2018-10-22T16:00:00-04:00 2018-10-22T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Analytical 3rd Year Student Seminars (October 24, 2018 4:00pm) https://events.umich.edu/event/54986 54986-13662982@events.umich.edu Event Begins: Wednesday, October 24, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Emily Mordan(Bailey Lab) , Kelcie Zegalia(Kennedy Lab)

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Other Wed, 24 Oct 2018 18:15:48 -0400 2018-10-24T16:00:00-04:00 2018-10-24T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Incorporation of Fluorescent Dye Molecules into Molecular Scaffolds: From Molecular Sensors to Switchable Catalysts (October 24, 2018 4:00pm) https://events.umich.edu/event/55302 55302-13716035@events.umich.edu Event Begins: Wednesday, October 24, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Increased environmental and impurity restrictions on consumer products, also the desire to reduce the cost and energy requirements of chemical transformations, have established a critical need for the development of more selective and efficient catalysts. An attractive approach to addressing this need is the use of catalysts that can be altered through post-synthetic modifications. Several commonly employed methods to change catalyst reactivity post-synthesis include the manipulation of pH, photoactivation, or even changes in solvent. This talk will discuss the synthesis, characterization, and reactivity of fluorescent dye-containing main group compounds that are capable of exhibiting a colorimetric response upon binding substrate molecules. This talk will also describe the incorporation of fluorescent dye-containing ligands into metal and main group complexes for switchable reactivity.
















Zachariah Heiden (Washington State University)

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Other Wed, 24 Oct 2018 18:15:48 -0400 2018-10-24T16:00:00-04:00 2018-10-24T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
C-H and C-O functionalization via radical chaperones (October 25, 2018 4:00pm) https://events.umich.edu/event/52741 52741-12986895@events.umich.edu Event Begins: Thursday, October 25, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our research is focused on harnessing the untapped reactivity of cheap and abundant chemical feedstocks in organic synthesis to enable the late-stage functionalization of complex natural products and other medicinally-relevant molecules. We have recently developed new approaches for selective C-H and C-O functionalization of alcohols and carbonyls, using a combination of radical (1e-) and closed shell (2e-) processes that act in concert with one another. These new radical chaperone strategies have enabled the development of chemical transformations with applications within molecules of biological and industrial interest.










David Nagib (The Ohio State University)

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Other Thu, 25 Oct 2018 18:15:46 -0400 2018-10-25T16:00:00-04:00 2018-10-25T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Analytical 3rd Year Student Seminars (October 26, 2018 4:00pm) https://events.umich.edu/event/54987 54987-13662983@events.umich.edu Event Begins: Friday, October 26, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Cole Chapman(Bailey Lab) , John Orlet(Bailey Lab)

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Other Fri, 26 Oct 2018 18:15:46 -0400 2018-10-26T16:00:00-04:00 2018-10-26T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: "The ParA/MinD family of ATPases make waves to position DNA, cell division, and organelles in bacteria" (October 26, 2018 4:00pm) https://events.umich.edu/event/56105 56105-13832575@events.umich.edu Event Begins: Friday, October 26, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: Positional information in eukaryotic cells is mainly orchestrated by cytoskeletal highways and their associated motor proteins like Myosin, Kinesin, and Dynein. Bacteria don’t have linear motors, so how are they spatially organized? I will be discussing three members of the ParA/MinD family of ATPases that are part of self-organizing systems that put things in their place in cells across the microbial world. I will first present the ATPase called ParA, which is part of the most common DNA-segregation system in bacteria. ParA proteins form dynamic waves on the nucleoid to position chromosomes and plasmids in opposite cell-halves so that they are faithfully inherited after cell division. I will then discuss the ATPase called MinD, which is part of a system that forms oscillatory waves on the inner membrane. The oscillation aligns cell division at mid-cell so that daughter cells are equal in size. Finally, I will introduce a new member of this ATPase family we call McdA, which is part of an organelle trafficking system in bacteria. Yes. Bacteria have organelles. Our work is shedding light on what seems to be a general mode of subcellular organization in bacteria – dynamic protein gradients surfing biological surfaces to impart positional information for a wide variety of fundamental biological processes. My new lab focuses on subcellular organization in bacteria with a strong emphasis towards reconstituting the self-organizing activities of these systems in a cell-free setup using purified and fluorescent labeled components. By visualizing the biochemistry driving self-organization outside the cell we are able to provide comprehensive molecular mechanisms that explain subcellular organization inside the cell.

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Workshop / Seminar Tue, 02 Oct 2018 16:14:04 -0400 2018-10-26T16:00:00-04:00 2018-10-26T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Anthony Vecchiarelli
Ultrafast Studies of Single Plasmonic Nanostructures (October 26, 2018 4:00pm) https://events.umich.edu/event/54352 54352-13574513@events.umich.edu Event Begins: Friday, October 26, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The optical properties of metal nanostructures are dominated by plasmon resonances, which are strong collective motions of the conduction electrons. These resonances are at the heart of a variety of schemes for molecular sensing and plasmon enhanced catalysis. However, the dynamics of plasmons can be difficult to study due to the distribution of particle sizes and shapes present in typical samples. In this talk I will describe single particle experiments that provide information about the ultrafast energy relaxation processes of plasmonic nanostructures, and how these structures interact with their environment. Examples of the processes that have been studied include the creation of novel hybrid states through coupling between plasmons and excitons, and the strange case of viscoelastic effects in the damping of vibrational modes of metal nanostructures.










Gregory Hartland (University of Notre Dame)

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Other Fri, 26 Oct 2018 18:15:45 -0400 2018-10-26T16:00:00-04:00 2018-10-26T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Chemistry - Biology Interface Training Program Symposium (October 30, 2018 1:00pm) https://events.umich.edu/event/56808 56808-14008216@events.umich.edu Event Begins: Tuesday, October 30, 2018 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry








Tarun Kapoor

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Other Tue, 30 Oct 2018 18:15:42 -0400 2018-10-30T13:00:00-04:00 2018-10-30T18:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Chemistry at the Intersection of Self-Assembly and Energy Conversion (October 30, 2018 4:00pm) https://events.umich.edu/event/52611 52611-12901950@events.umich.edu Event Begins: Tuesday, October 30, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry



Nature uses a complex array of chromophores, optimally organized both spatially and electronically, to carry out photoinduced energy and electron transfer from pigment molecules to a reaction center. The fundamental processes underpinning photosynthesis provide the basis for artificial solar conversion systems that include photovoltaic cells, photoanodes and photocathode catalysts to generate electricity or fuels. It is the supramolecular arrangement of multiple chromophores that results in the emergent properties associated with natural light harvesting complexes, including enhanced absorption, efficient energy transfer between pigments, and electron-transfer. We are interested in self-assembled discrete metal-organic assemblies containing multiple chromophores as functional models of supramolecular light harvesting architectures. Specifically, we are actively designing systems to identify the optimal alignment, spacing, and electronic structure to enable directional EnT and photoredox chemistry while maximizing broadband absorption matched to the solar flux. The formation of structurally complex metal-organic polygons, polyhedra, and prisms (MOPs) is greatly facilitated by coordination-driven self-assembly methods which furnish them in single, one-pot reactions. An ever-growing library of organic ligands (donors) and metal/organometallic complexes with substitutionally labile coordination sites (acceptors) serves as the basis for a suite of metallacycles and cages characterized by their well-defined internal cavities and predictable topologies. The rigid organic backbones that once served solely as structural elements have more recently been exploited for their ability to impart interesting photophysical properties to their parent MOPs. Strategies include tethering pendant fluorophores through covalent coupling chemistry and selecting inherently emissive building blocks, with an emphasis on exploiting Ru, Ir, and Pt-based complexes.








Timothy Cook (University of Buffalo)

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Other Tue, 30 Oct 2018 18:15:42 -0400 2018-10-30T16:00:00-04:00 2018-10-30T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Analytical 3rd Year Student Seminars (October 31, 2018 4:00pm) https://events.umich.edu/event/54988 54988-13662984@events.umich.edu Event Begins: Wednesday, October 31, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Bonsall Robert(McCrory Lab) , Geng Luqan(Kennedy Lab)

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Other Wed, 31 Oct 2018 18:15:41 -0400 2018-10-31T16:00:00-04:00 2018-10-31T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Undergraduates Teaching Chemistry Through Outreach (November 2, 2018 12:00pm) https://events.umich.edu/event/53786 53786-13461543@events.umich.edu Event Begins: Friday, November 2, 2018 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Ellen Yezierski (Miami University)

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Other Fri, 02 Nov 2018 18:15:42 -0400 2018-11-02T12:00:00-04:00 2018-11-02T00:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Innovative Strategies for Nonconventional Water Splitting and Beyond (November 2, 2018 4:00pm) https://events.umich.edu/event/53785 53785-13461542@events.umich.edu Event Begins: Friday, November 2, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

One of the challenges to realize large-scale H2 production from water electrolysis is the lack of competent and inexpensive electrocatalysts. Our group recently discovered that surface modification of metallic nickel with nitrogen resulted in a superior electrocatalyst for H2 evolution under neutral condition, rivaling the performance of the state-of-the-art platinum-based catalysts. In addition, since water oxidation is more kinetically challenging while its product O2 is not of significant value, we are also interested in exploring alternative oxidation reactions which can not only provide electrons for H2 evolution at the cathode but also yield value-added organic products at the anode. Within this context, biomass-derived intermediate compounds are found to be suitable candidates for electrocatalytic upgrading, which can be integrated with H2 production under alkaline conditions. Finally, a new electrolyzer design for decoupled water splitting and organic transformation will be presented, which is able to substantially reduce voltage inputs and mitigate the H2/O2 mixing issue commonly encountered in conventional water electrolysis.












Yujie Sun (University of Cincinnati)

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Other Fri, 02 Nov 2018 18:15:41 -0400 2018-11-02T16:00:00-04:00 2018-11-02T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Titles: "Quantitative analysis of the spindle assembly checkpoint (SAC)", Chu Chen and "Pattern Formation in 2D Tissues via Mechanics: From Juvenile Zebrafish to Human Embryonic Stem Cells", Hayden Nunley (November 2, 2018 4:00pm) https://events.umich.edu/event/53435 53435-13381404@events.umich.edu Event Begins: Friday, November 2, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstracts:
Chu Chen - In mammalian cells, accurate chromosome segregation during mitosis requires that kinetochores of sister chromatids attach to microtubules emanating from opposite spindle poles. In the absence of kinetochore-microtubule attachment, the spindle assembly checkpoint (SAC) is activated to delay anaphase onset. Over the past two decades, researchers have basically revealed the fundamental biochemical pathway of SAC signaling. However, how SAC effectively halts mitosis progression in the presence of very few unattached kinetochores is less addressed. In this talk, quantitative evidence will be presented which suggest the presence of synergistic actions in SAC. Hypothesis about the underlying mechanism and preliminary data from ongoing validation experiments will also be discussed. This cooperativity may enable a single unattached kinetochore to produce a strong enough signal.-

and

Hayden Nunley - Many epithelial tissues are composed of several types of cells with distinct functions. For proper functioning of the tissues, it is often important that the different types of cells form a spatial pattern. The specific biological details of how the cells interact to form these patterns are often not fully understood. To study the developmental processes in the absence of detailed biological information, it is useful to test which simplified physical models are consistent with experimental observations. With insights from these models, we identify specific candidate proteins or cellular structures necessary for the interaction, and generate predictions of how specific manipulations will affect tissue patterning. In this spirit, we will discuss the formation of a crystal of cone photoreceptors in juvenile zebrafish retinae. We find that the structure and arrangement of defects in the tissue are consistent with a purely mechanical model in which cones of one specific type interact with other cones of the same type at short range. We identify a specific cellular structure as a candidate for mediating this interaction. We will also discuss neural fate specification in human embryonic stem cell colonies. To study this pattern which has a length scale that does not scale with colony size, we propose a model in which cells respond to mechanical stresses by altering their contractility.

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Workshop / Seminar Tue, 16 Oct 2018 11:24:41 -0400 2018-11-02T16:00:00-04:00 2018-11-02T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
John Essigmann Panel Discussion (November 5, 2018 4:00pm) https://events.umich.edu/event/53083 53083-13222317@events.umich.edu Event Begins: Monday, November 5, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry
















John Essigmann (Massachusetts Institute of Technology)

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Other Mon, 05 Nov 2018 18:15:39 -0500 2018-11-05T16:00:00-05:00 2018-11-05T18:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Unconventional Building Blocks for Functional Polymeric Materials (November 6, 2018 4:00pm) https://events.umich.edu/event/52163 52163-12502488@events.umich.edu Event Begins: Tuesday, November 6, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The Klausen group designs and synthesizes unconventional molecular building blocks
for the construction of diverse functional polymeric architectures. Motivated by the conviction that the synthesis of new materials drives the discovery of new applications, this talk will describe the synthesis and polymerization of novel hybrid inorganic-organic monomers. The materials we prepare are expected to find application in energy science as earth abundant quantum materials or as plastics with finely controlled physical properties.
The semiconductor silicon has revolutionized life in the last century, from the development of computer chips to the discovery of solar cells that make telecommunication satellites possible. The frontier for silicon research and development is at the nanoscale. The incredible potential of nanoscale silicon arises from the attractive properties it shares with bulk silicon, such as earth abundance and low precursor toxicity, and the distinctive optical and electronic properties emerging at small sizes. This talk describes the design and synthesis of new molecular forms of silicon, as well as the characterization of materials properties and the fabrication of electronic devices based on molecular silicon.
BN 2-Vinylnaphthalene (BN2VN) is a solution to a long-standing challenge in polymer chemistry, the copolymerization of nonpolar and polar monomers. Though the incorporation of polar functionality into nonpolar polymers is an essential strategy for modulating physical properties, challenges in their direct copolymerization include phase separation, significant differences in reactivity, and the limited compatibility of polar functional groups with polymerization catalysts. We show that BN2VN retains the reactivity of styrene, while post- polymerization modification of the C-B bond provides hydroxyl-functionalized polymers, or styrene-vinyl alcohol (SVA) copolymers.


















Bekka Klausen (Johns Hopkins University)

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Other Tue, 06 Nov 2018 18:15:40 -0500 2018-11-06T16:00:00-05:00 2018-11-06T17:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Organizational Studies Info Night! (November 6, 2018 5:30pm) https://events.umich.edu/event/55542 55542-13756887@events.umich.edu Event Begins: Tuesday, November 6, 2018 5:30pm
Location: Chemistry Dow Lab
Organized By: Organizational Studies Program (OS)

Want to learn more about Organizational Studies?

Join us to hear more about this interdisciplinary major based in social sciences where students customize their own education. Enjoy a small community of dedicated and ambitious students with access to top-notch faculty and an engaged alumni network. You'll have the opportunity to hear from the Program Director, Major Advisor, Prospective Student Advisors, and a diverse panel of OS students!

Visit our website in the meantime for more information on the curriculum, application, or to sign-up for a prospective student advising meeting.

Follow us on Facebook to engage with our community and stay up-to-date with OS happenings!

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Meeting Tue, 18 Sep 2018 11:15:27 -0400 2018-11-06T17:30:00-05:00 2018-11-06T19:00:00-05:00 Chemistry Dow Lab Organizational Studies Program (OS) Meeting OS
Symmetry Making and Breaking in Seeded Growth of Metal Nanocrystals (November 8, 2018 4:00pm) https://events.umich.edu/event/52487 52487-12809234@events.umich.edu Event Begins: Thursday, November 8, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Crystal growth theory predicts that heterogeneous nucleation will occur preferentially at defect sites, such as the vertices rather than the faces of shape-controlled seeds. Platonic metal solids are generally assumed to have vertices with nearly identical chemical potentials, and also nearly identical faces, leading to the useful generality that heterogeneous nucleation preserves the symmetry of the original seeds in the final product. This presentation will discuss how this generality can be used to access stellated metal nanocrystals with high and tunable symmetries for applications in plasmonics. This presentation will also discuss the limits of this generality in the extreme of low supersaturation. A strategy for favoring localized deposition that differentiates between both different vertices and different edges or faces, i.e., regioselective deposition, will be demonstrated. Such regioselective heterogeneous nucleation was achieved at low supersaturation by a kinetic preference for high-energy defect-rich sites over lower-energy sites. This outcome was enhanced by using capping agents to passivate facet sites where deposition was not desired. Collectively, the results presented provide a model for breaking the symmetry of seeded growth and for achieving regioselective deposition.






















Sara Skrabalak (Indiana University)

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Other Thu, 08 Nov 2018 18:15:44 -0500 2018-11-08T16:00:00-05:00 2018-11-08T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Active Learning Strategies Lunch Series (November 9, 2018 11:30am) https://events.umich.edu/event/57220 57220-14130947@events.umich.edu Event Begins: Friday, November 9, 2018 11:30am
Location: Chemistry Dow Lab
Organized By: Instructional Support Services

Join us for an informal gathering in one of LSA's team-based learning (TBL) classrooms, CHEMISTRY A859, for lunch and a lively discussion about a variety of topics related to teaching. This session will focus on managing student group dynamics. Lunch is provided.

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Workshop / Seminar Tue, 30 Oct 2018 14:48:30 -0400 2018-11-09T11:30:00-05:00 2018-11-09T12:30:00-05:00 Chemistry Dow Lab Instructional Support Services Workshop / Seminar Active Learning Strategies Lunch Series
Seminar Title: “Discovering a new broad antiviral inhibitor” (November 9, 2018 4:00pm) https://events.umich.edu/event/53438 53438-13381407@events.umich.edu Event Begins: Friday, November 9, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: The human ESCRT protein machinery is required for membrane remodeling events including multivesicular body biogenesis, cellular abscission, and viral budding. Specifically, the Pro-Thr-Ala-Pro (PTAP) motif of viral Gag proteins targets the ESCRT-I complex via a direct interaction with Tsg101 (tumor susceptibility gene 101). This interaction is necessary for the viral Gag proteins to be recruited to the membrane. Naturally this interaction site has been the target for designing anti-viral drugs by mimicking the PTAP motif. Recently we identified a small molecule inhibitor of HIV budding, which we expected to bind to the PTAP recognition site of Tsg101. This molecule belongs to a family of proton pump inhibitors that are clinically used to treat acid reflux. Initial characterization using solution NMR indicated that the inhibitor interacts with Tsg101 outside of the PTAP recognition site. The structure of Tsg101 and a small molecule inhibitor complex that we solved reveals a covalent interaction occurring at the ubiquitin (Ub) binding site of Tsg101. Tsg101’s main contribution to ESCRT-I function is in recognition of and binding to Ub-modified cargo. The fact that the inhibitor targeted ubiquitin-Tsg101 binding was significant, since this interaction was previously thought to have little influence on the HIV-1 life cycle. Using our new inhibitor as a tool, we uncovered the essential role of Ub-Tsg101 interaction to promote degradation of HIV-1 Gag protein in the cell and to block co-localization of Tsg101 and HIV-1 Gag at the plasma membrane required for budding. In addition, we also showed that Tsg101 has another binding site that can contact the second Ub moiety in K48 or K63 linked di-Ub molecules. This second Ub binding site on Tsg101 has a weaker affinity compared to the first site and its observation required the use of novel NMR methodology. Our recent results show the potential for development of broad spectrum antiviral inhibitor based on clinically approved proton pump inhibitors targeting Tsg101 and we also provided the first evidence for the important role of Tsg101 and di-Ub interaction in viral replication.

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Workshop / Seminar Wed, 03 Oct 2018 11:43:15 -0400 2018-11-09T16:00:00-05:00 2018-11-09T17:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Nico Tjandra
RNA tertiary structure and its role in molecular recognition: lessons from self-splicing group II introns and lncRNA molecules. (November 12, 2018 4:00pm) https://events.umich.edu/event/50829 50829-11876205@events.umich.edu Event Begins: Monday, November 12, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The vast majority of our gene products are noncoding RNA molecules, many of which have elaborate three-dimensional structures. Despite the importance of RNA tertiary structure in gene expression, the scope of our knowledge about RNA structure and molecular recognition is limited. This is largely due to the small number of high resolution RNA structures and a paucity of studies on small molecule recognition by RNA. To address this problem, we have focused on understanding the molecular architecture and catalytic mechanism of group II introns, which are RNAs that catalyze their own splicing. We have also used the catalytic activity of group II introns to carry out high throughput screening of small molecule inhibitors, which we have optimized and developed as antifungal agents. These studies have been complemented by parallel studies on other long noncoding RNAs that lack catalytic activity, with the goal of identifying approaches for understanding and targeting RNA tertiary structures within the large network of regulatory lncRNAs.








Anna Marie Pyle (Yale University)

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Other Mon, 12 Nov 2018 18:15:39 -0500 2018-11-12T16:00:00-05:00 2018-11-12T17:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: "Synthesis and Electrochemical Characterization of Magnesium-Ion Battery Electrolytes" (November 14, 2018 2:00pm) https://events.umich.edu/event/57255 57255-14142072@events.umich.edu Event Begins: Wednesday, November 14, 2018 2:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Adam Crowe (Advisor: Prof. Bart M. Bartlett)

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Other Wed, 14 Nov 2018 18:15:37 -0500 2018-11-14T14:00:00-05:00 2018-11-14T15:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Hydrocarbon Functionalization in Porous Materials (November 15, 2018 4:00pm) https://events.umich.edu/event/57177 57177-14124206@events.umich.edu Event Begins: Thursday, November 15, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Hydrocarbons are cheap and abundant feedstocks readily derived from both fossil fuels and emerging renewable resources. Despite their abundance, hydrocarbons have limited applications in chemical synthesis due to the inertness of C–H bonds towards both homolytic and heterolytic bond cleavage. I will share two very different approaches to the selective functionalization of simple hydrocarbons that address these challenges. First, I will highlight a bio-inspired approach to achieve selective alkane hydroxylation using iron-based metal–organic frameworks. The critical influence of both primary and secondary coordination sphere elements on catalyst reactivity, selectivity, and stability will be detailed. Second, I will describe the identification and characterization of a simple heterogeneous base catalyst that converts aromatic hydrocarbons, CO2, and methanol into the corresponding aromatic esters at elevated temperatures. The transformation occurs via a two-step, semi-continuous cycle, and represents the first hydrocarbon CO2 insertion process that does not consume any energy-intensive stoichiometric reagents.






Dianne Xiao, PhD (Stanford University)

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Other Thu, 15 Nov 2018 18:15:33 -0500 2018-11-15T16:00:00-05:00 2018-11-15T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Halogen Bonding in Single Electron Transfers to Initiate New Radical Reactions (November 16, 2018 4:00pm) https://events.umich.edu/event/53007 53007-13179050@events.umich.edu Event Begins: Friday, November 16, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Non-covalent halogen bonding has been utilized in biological systems to increase the binding affinities of synthetic drugs to receptor sites in the body. These weak interactions typically mimic hydrogen bonding but offer a hydrophobic alternative to the typical polar or charged groups that are present in natural biological systems. Recently, our lab has identified halogen bonding as an important feature of electron-transfer for initiating certain radical reactions. We have strong preliminary experimental and computational evidence demonstrating the importance of halogen bonding in the context of radical fluorination, and believe a generalized strategy may be applied to a wide range of free radical reactions including heteroarene alkylation and arylation.









Ryan Baxter (University of California at Merced)

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Other Fri, 16 Nov 2018 18:15:35 -0500 2018-11-16T16:00:00-05:00 2018-11-16T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: Unraveling the enigma of the translocator protein 18kD, TSPO. (November 16, 2018 4:00pm) https://events.umich.edu/event/53439 53439-13381408@events.umich.edu Event Begins: Friday, November 16, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract:
The precise physiological roles of the ancient and conserved membrane protein TSPO (otherwise known as the translocator protein 18kD or the peripheral benzodiazepine receptor) remain obscure. The original discovery of TSPO in mammals occurred when it was found as an additional binding site for benzodiazepine drugs. High expression in tissues involved in steroid hormone synthesis along with other evidence suggested a regulatory role in cholesterol uptake into mitochondria, especially under stress conditions. More recently, TSPO knockout mouse models show inconsistent characteristics that weaken this hypothesis, although some common features exist: the loss of TSPO increased lipid oxidation, decreased ATP synthesis and decreased mitochondrial membrane potential. Another common feature of TSPO across all kingdoms appears to be the ability to bind porphyrins, including heme and protoporphyrin IX, likely endogenous ligands. Yet despite decades of research, there is no consensus regarding the nature and mechanism of TSPO effects. In this talk, I will discuss the current state of the structural, biochemical, and physiological analyses that are beginning to reveal how TSPO functions.

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Workshop / Seminar Thu, 08 Nov 2018 14:14:53 -0500 2018-11-16T16:00:00-05:00 2018-11-16T17:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Michael Garavito
Thesis Defense: "Development of Strategies for the Synthesis of Heterocycles and Carbocycles; and Investigation of Chemistry Course Placement on Undergraduate Students" (November 19, 2018 1:00pm) https://events.umich.edu/event/57256 57256-14142073@events.umich.edu Event Begins: Monday, November 19, 2018 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Elsa Hinds (Advisor: Prof. John P. Wolfe)

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Other Mon, 19 Nov 2018 18:15:30 -0500 2018-11-19T13:00:00-05:00 2018-11-19T14:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Catalytic Manipulation of Reactivity and Selectivity at High-Valent Nuclei (November 19, 2018 4:00pm) https://events.umich.edu/event/57146 57146-14121949@events.umich.edu Event Begins: Monday, November 19, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

This presentation will examine aspects of reactivity and selectivity discovered through the exploration of the chemistry of high-valent nuclei [Au(III), Pt(IV), and I(III)]. The first part concerns two examples wherein transition metals are examined as substrates for catalytic reactions rather than in their traditional role as catalysts. Operating from this perspective, supramolecular catalysis of C(sp3)-C(sp3) reductive elimination and organoborane catalyzed C(sp3)-CF3 reductive elimination will be discussed, with the latter applied to [18F]-radiotrifluoromethylation. The second section will continue the focus on fluorination through the development of a new aryliodine catalyst for enantioselective olefin difluorination, exploring structural features that improve catalyst robustness and selectivity and enabling the preparation of chiral fluorinated building blocks.




Mark Levin, PhD (Harvard University)

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Other Mon, 19 Nov 2018 18:15:30 -0500 2018-11-19T16:00:00-05:00 2018-11-19T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Roles of elusive translational GTPases (LepA and BipA) come to light (November 20, 2018 4:00pm) https://events.umich.edu/event/53787 53787-13461544@events.umich.edu Event Begins: Tuesday, November 20, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Protein synthesis relies on several translational GTPases (trGTPases), related proteins that couple the hydrolysis of GTP to specific molecular events on the ribosome. Most bacterial trGTPases, including IF2, EF-Tu, EF-G, and RF3, play well-known roles in translation. The cellular functions of LepA (also termed EF4) and BipA (also termed TypA), on the other hand, have remained enigmatic. I will discuss recent evidence that LepA and BipA function in biogenesis of the 30S and 50S subunit, respectively. These findings have important implications for ribosome biogenesis in bacteria.










Kurt Fredrick (The Ohio State University)

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Other Tue, 20 Nov 2018 18:15:28 -0500 2018-11-20T16:00:00-05:00 2018-11-20T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab