Happening @ Michigan https://events.umich.edu/list/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. RNA as a Drug Target and Material for Nanotechnology (September 24, 2018 4:00pm) https://events.umich.edu/event/51011 51011-11941993@events.umich.edu Event Begins: Monday, September 24, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Research in the Hermann lab is focused on exploring the structure, molecular recognition and assembly of ribonucleic acid (RNA) architectures.
One key goal is the development of therapies targeting noncoding RNA (ncRNA). ncRNAs participate as key players in many biological processes and may adopt complex folds that are required for function. The development of ligands that bind selectively to ncRNA targets opens new ways to expand the existing repertoire of protein-directed therapeutics. I will present our research on the discovery of an unprecedented molecular switch target in the genome of RNA viruses including the human pathogen hepatitis C virus (HCV) and the development of ligands that inhibit the viral switch.
In the second part of the presentation, I will outline how we use RNA crystal structures to design nano-architectures that self-assemble from small RNA motifs and may serve as combinatorial platforms for applications in molecular recognition, sensor and catalyst development as well as protein interaction studies.












Thomas Hermann (University of California, San Diego)

]]>
Other Mon, 24 Sep 2018 18:15:45 -0400 2018-09-24T16:00:00-04:00 2018-09-24T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Open Lecture | Writing in-between languages: poetry in a second language (September 25, 2018 3:00pm) https://events.umich.edu/event/54814 54814-13645242@events.umich.edu Event Begins: Tuesday, September 25, 2018 3:00pm
Location: Chemistry Dow Lab
Organized By: LSA Honors Program

When the native language becomes unstable, and writers are forced to abandon it, or when experience simply destroys the transaction of meaning or truth between a writer and her language, the notion of the “place of writing” itself becomes destabilized and abstracted. This lecture probes the poet's relationship with an adopted language, acknowledging losses and gains, and offers a glimpse into the experience of writing in-between languages, hovering at the borders between them.

]]>
Lecture / Discussion Wed, 05 Sep 2018 14:34:57 -0400 2018-09-25T15:00:00-04:00 2018-09-25T16:00:00-04:00 Chemistry Dow Lab LSA Honors Program Lecture / Discussion Carmen Bugan
Multi-scale chemistry: From molecular to microsystems (September 27, 2018 4:00pm) https://events.umich.edu/event/53783 53783-13461540@events.umich.edu Event Begins: Thursday, September 27, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The design and manipulation of molecules and chemical reactions offers the possibility for the engineering of materials and devices at multiple length scales from the molecular to the nano, micro, and macro. By way of several examples, this seminar will highlight how chemistry can be used across length scales to create programmable materials, 3D biosensors, and physiologically responsive robots.























David Gracias (Johns Hopkins University)

]]>
Other Thu, 27 Sep 2018 18:15:50 -0400 2018-09-27T16:00:00-04:00 2018-09-27T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Folded Viral RNAs that Sense and Manipulate the Host Cell Machinery: Windows to RNA Structure-Based Regulation (September 28, 2018 4:00pm) https://events.umich.edu/event/53429 53429-13381398@events.umich.edu Event Begins: Friday, September 28, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: RNA is perhaps the most functionally diverse biological macromolecule, due in large part to its ability to adopt a wide range of conformationally dynamic structures. The Kieft Lab is interested in understanding how RNA can adopt diverse three-dimensional folds, how those folds give rise to its many biological roles, and how conformational changes confer RNA’s ability to regulate so many processes. We are particularly interested in viral RNAs, which are fine-tuned by evolution to elegantly and powerfully interact with and manipulate the cellular machinery of the host cell; these viral RNAs provide a “window” into the greater RNA world. In this presentation, I will present some of our recent findings in regard to a viral RNA that adopts an unexpected tertiary structure. This RNA element undergoes programmed conformational changes that are triggered by its interactions with the host cell machinery and this is responsible for its unique function. This RNA may be a paradigm for novel modes of regulation linked to dynamic RNA conformational changes.

]]>
Workshop / Seminar Wed, 26 Sep 2018 14:41:29 -0400 2018-09-28T16:00:00-04:00 2018-09-28T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Jeffrey Kieft
2018 Organic Reactions Symposium (October 1, 2018 1:00pm) https://events.umich.edu/event/50748 50748-11861929@events.umich.edu Event Begins: Monday, October 1, 2018 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

We recently explored the possibility of using gold(I) catalysts to activate allenes towards alcohol nucleophiles to effect allenoate Claisen rearrangements. However, instead of allene activation, a pendant ester was transesterified and etherified, which led to our development of a gold-catalyzed, microwave protocol to activate alcohols to form ethers and amines via an intermolecular, SN1-type reaction. Ultimately, in lieu of a metal-catalyzed version, we have developed a Bronsted acid-catalyzed allenoate Claisen that affords the corresponding products in high yields and enantioselectivities. Lessons learned from these studies have led to the serendipitous discovery of a silver-catalyzed, N-formylation reaction and have informed our development of an anti-Markovnikov hydroamination reaction.








Scott Denmark(University of Illinois) , Noah Burns(Stanford University) , Anna Wenzel(Claremont McKenna College)

]]>
Other Mon, 01 Oct 2018 18:15:51 -0400 2018-10-01T13:00:00-04:00 2018-10-01T18:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Open Lecture | Artistic distance and the language of oppression (October 2, 2018 3:00pm) https://events.umich.edu/event/54817 54817-13645249@events.umich.edu Event Begins: Tuesday, October 2, 2018 3:00pm
Location: Chemistry Dow Lab
Organized By: LSA Honors Program

Writing is an emotional process and it works when it makes us feel, both as writers and readers. Yet a certain emotional distance is necessary when one writes poetry with the language of oppression, especially when one has been the victim, and offers a historical testimony. What kind of liberties can one take with the material? What constitutes appropriate artistic utterance when one navigate the territories of poetry about the hard truths? Rescuing words from screams of pain and anger into poetic expression, which shows the effect of oppression on the inner landscape of feeling, is what poetry offers as an art.

]]>
Lecture / Discussion Wed, 05 Sep 2018 14:38:46 -0400 2018-10-02T15:00:00-04:00 2018-10-02T16:00:00-04:00 Chemistry Dow Lab LSA Honors Program Lecture / Discussion Carmen Bugan
Insights into Complex Molecular Processes from Quantitative Atomistic Simulations (October 2, 2018 4:00pm) https://events.umich.edu/event/52807 52807-13081672@events.umich.edu Event Begins: Tuesday, October 2, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Molecular dynamics simulations are a powerful means to provide
molecular-level insights into processes ranging from gas-phase
reaction dynamics to complex non-reactive and reactive rearrangements
in biological systems. The utility of such simulations depends
sensitively on the accuracy with which the intermolecular interactions
are represented. In this seminar I will discuss recent progress in
force field development including multipolar force fields, reproducing
kernel Hilbert space techniques and machine learning and their
application to spectroscopy and reactive processes in the condensed
phase. The focus is on directly linking experimental observations with
computations which provides molecular level understanding of
spectroscopic observables and time scales from state-of-the art
experiments. A typical example discussed will be the relationship
between structure and dynamics for infrared and X-ray absorption
spectroscopy of biomolecules or the thermodynamics of reversed phase
liquid chromatography.
















Markus Meuwly (University of Basel, Switzerland)

]]>
Other Tue, 02 Oct 2018 18:15:46 -0400 2018-10-02T16:00:00-04:00 2018-10-02T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
2018 Ta-You Wu Lecture in Physics | Topological Quantum Matter, Entanglement, and a "Second Quantum Revolution" (October 3, 2018 4:10pm) https://events.umich.edu/event/53581 53581-13410079@events.umich.edu Event Begins: Wednesday, October 3, 2018 4:10pm
Location: Chemistry Dow Lab
Organized By: Department of Physics

While the laws of quantum mechanics have remained unchanged and have passed all tests for the last eighty-five years, new discoveries about the exotic states that they allow, “entanglement”, and ideas from quantum information theory, have greatly changed our perspective, and some believe that a “second quantum revolution” is currently underway. The discovery of unexpected “topological states of matter”, and their possible use for “topologically-protected quantum information processing” is one of the important themes of these developments, and will be described.

]]>
Lecture / Discussion Tue, 23 Oct 2018 17:03:27 -0400 2018-10-03T16:10:00-04:00 2018-10-03T17:10:00-04:00 Chemistry Dow Lab Department of Physics Lecture / Discussion Chemistry Dow Lab
Exploring Indoor Chemistry: Criegees, Chlorohydrins, and Nitrous Acid (October 4, 2018 4:00pm) https://events.umich.edu/event/52146 52146-12477549@events.umich.edu Event Begins: Thursday, October 4, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The chemical interactions that proceed indoors have not been as well studied as those that occur in outdoor environments. Rather, indoors, focus has primarily been given to emissions from building materials and effects of ventilation. However, it is known that oxidative and partitioning processes occur on most indoor surfaces that affect the chemical exposure that we all experience. Indeed, the concentrations of many chemical species are higher indoors than outdoors. This talk will present examples of indoor oxidative processes that arise via ozone, which is introduced by intake of outdoor air, and via cleaning agents, such as chlorine bleach. Highly reactive surfaces indoors include human skin oils and cooking emissions, and particular attention will be given to the ozonolysis products formed from Criegee intermediates. The nature of non-reactive partitioning in indoor species will also be examined. In particular, new field measurements indicate that molecules that are normally viewed as being highly reactive, such as nitrous acid, are sorbed to indoor surfaces in significant amounts.








Jonathan Abbatt (University of Toronto)

]]>
Other Thu, 04 Oct 2018 18:15:51 -0400 2018-10-04T16:00:00-04:00 2018-10-04T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Analytical 3rd Year Student Seminars (October 5, 2018 4:00pm) https://events.umich.edu/event/54982 54982-13662978@events.umich.edu Event Begins: Friday, October 5, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Megan Connor(Shultz Lab) , Matt Sorensen(Kennedy Lab)

]]>
Other Fri, 05 Oct 2018 18:15:49 -0400 2018-10-05T16:00:00-04:00 2018-10-05T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: "Functional approaches to understanding the development of the Small Multidrug Resistance family of transporters"- Chris Macdonald and "The effect of disruption of synaptic signaling on brain networks" - Maral Budak (October 5, 2018 4:00pm) https://events.umich.edu/event/53431 53431-13381399@events.umich.edu Event Begins: Friday, October 5, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract:
Chris Macdonald - The Small Multidrug Resistance (SMR) family of prokaryotic and archaean proton-coupled transporters provides a window into the evolutionary events that generated the molecular diversity of membrane protein function today. These small 4-pass integral membrane proteins assemble into functional dimers with an unusual antiparallel architecture. The most well-studied example, EmrE, is a homodimeric member that provides resistance to a broad range of hydrophobic cationic aromatic compounds. This talk will cover recent work in the Stockbridge lab that has fundamentally altered our understanding of this family, including functional characterization through flux measurements and solid-supported membrane (SSM) electrophysiology, in vivo metabolic assays, and phylogenetic analysis. We suggest an evolutionary trajectory for the development of new functions in these small proteins.

and

Maral Budak -The information transmission between neurons and brain regions occurs via synapses. Therefore, disruption of synaptic signaling (e.g. synaptic failure or desynchronization of spikes) may have devastating outcomes, such as loss of consciousness or neurodegenerative diseases. First, our objective is understanding the effect of synaptic failure on functional connectivity of different network structures, and we observed that synaptic failure does not always decrease the coherence of neuronal networks, but sometimes promotes the formation of coherent states of activity in the networks. Next, we aim to understand the mechanism of hidden hearing loss caused by myelinopathy. Recently, it’s been hypothesized that disruption of myelination patterns at auditory nerves (AN) causes desynchronization of AN spiking activity. To test this hypothesis, we constructed a reduced biophysical model for a population of inner hair cells with postsynaptic auditory nerve fibers. As a result, our model confirms that heminodal disruption causes desynchronization of AN spikes leading to a loss of temporal resolution.

]]>
Workshop / Seminar Mon, 01 Oct 2018 11:59:37 -0400 2018-10-05T16:00:00-04:00 2018-10-05T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
Nitric Oxide Signaling: From Prokaryotes to Humans (October 8, 2018 4:00pm) https://events.umich.edu/event/50775 50775-11864796@events.umich.edu Event Begins: Monday, October 8, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Nitric oxide (NO) has long been known to be an intermediate in bacterial pathways of denitrification. It is only since the middle to late 1980s that it was found to play a central role in a much broader biology context. For example, it is now well established that NO acts as a signaling agent in higher organisms. Yet NO is toxic and reactive under biological conditions. How is the biology carried out by NO controlled? How is NO used and the inherent toxicity avoided? How do organisms tell the difference between NO and O2? What is the biological output? A molecular perspective on ligand discrimination in hemoproteins has emerged as has a further understanding and predictions about selective ligand sensing and function in biology.














Michael Marletta (University of Berkeley)

]]>
Other Mon, 08 Oct 2018 18:15:47 -0400 2018-10-08T16:00:00-04:00 2018-10-08T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Nandini Ananth: Charge Transfer Dynamics, Excited State Energetics, and Organic Photovoltaics (October 9, 2018 4:00pm) https://events.umich.edu/event/56196 56196-13860237@events.umich.edu Event Begins: Tuesday, October 9, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Michigan Institute for Computational Discovery and Engineering

Designing molecular materials for use as organic photovoltaics, molecular electronics, and photocatalysts is a multifaceted challenge requiring a detailed understanding of both the excited state energetics and the dynamics of charge and energy transfer. We address the dynamic challenge by developing new methods based on the path integral formulation of quantum mechanics that are uniquely suited to the simulation of photo-initiated excited state dynamics in the condensed phase. We then tackle the characterization of the excited state manifold in molecular systems using a combination of high-level electronic structure methods to accurately calculate excited state energies, normal mode analysis to quantify vibronic couplings, and novel orbital analyses to uncover structure-spectrum correlations.
In this talk, we focus on one target application: designing chromophores that exhibit ultrafast Singlet Fission (SF), a phenomenon that has the potential to significantly increase organic solar cell efficiency. We investigate SF in non-bonded and covalently bonded pentacene dimers: we uncover two distinct mechanistic pathways for ultrafast SF and we identify molecular geometries and bonding motifs that can be modified to enhance efficiency in each case. Finally, we combine the insights obtained from our theoretical investigations to generate a priori design principles for next-generation SF chromophores, and working with experimental collaborators, we verify them.

Nandini Ananth is an associate professor in the department of Chemistry and Chemical Biology at Cornell University. She received her bachelor's degree in Chemistry from Stella Maris College in Chennai, India, and a Masters in chemistry from the Indian Institute of Technology Madras.

]]>
Workshop / Seminar Sun, 30 Sep 2018 15:14:35 -0400 2018-10-09T16:00:00-04:00 2018-10-09T17:00:00-04:00 Chemistry Dow Lab Michigan Institute for Computational Discovery and Engineering Workshop / Seminar Ananth
Watching metalloenzymes at work (October 9, 2018 4:00pm) https://events.umich.edu/event/53784 53784-13461541@events.umich.edu Event Begins: Tuesday, October 9, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Structures of bioinorganic catalysts can often uniquely rationalize important aspects of chemical and biological reaction control. My research group studies the structural differences between members of large metalloenzyme superfamilies that share common characteristics but trigger different reactions or use distinct cofactors. We have initially focused on systems unified in their ability to activate strong C-H, N-H, or O-H bonds. Key objectives include identification of the outcome-dictating structural features of a given catalyst and structure-guided reprogramming for new function. To achieve these ends, we determine stable reactant and product complexes, with an increasing focus on development and implementation of crystallographic approaches to study metalloenzyme reaction intermediates. These experiments are challenging due to the fleeting and reactive nature of these states but uniquely informative because of the fully contextualized view they provide at critical points in the catalytic cycle.












Amie Boal (The Pennsylvania State University)

]]>
Other Tue, 09 Oct 2018 18:15:46 -0400 2018-10-09T16:00:00-04:00 2018-10-09T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Analytical 3rd Year Student Seminars (October 10, 2018 4:00pm) https://events.umich.edu/event/54983 54983-13662979@events.umich.edu Event Begins: Wednesday, October 10, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry








Nicole Olson(Ault Lab) , Daniel Vallejo(Ruotolo Lab)

]]>
Other Wed, 10 Oct 2018 18:15:47 -0400 2018-10-10T16:00:00-04:00 2018-10-10T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Quantum Coherence in Chemistry: Tackling the Decoherence Challenge (October 11, 2018 4:00am) https://events.umich.edu/event/52043 52043-12376521@events.umich.edu Event Begins: Thursday, October 11, 2018 4:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

A subject of considerable current interest in Chemistry is the possibility of using non-trivial quantum mechanical effects, such as coherence and interference, to enhance molecular function. This possibility is hindered by decoherence processes that prevent matter from fully exhibiting its quantum features. In this talk, I will summarize our progress understanding decoherence in molecular processes, and in particular electronic decoherence. I will discuss the basic mechanisms for electronic coherence loss, methods to quantify the decoherence, and a general theory of decoherence timescales. The talk with conclude with some novel prospects on the possibility of using lasers to control electronic decoherence in molecules.






Ignacio Franco (University of Rochester)

]]>
Other Thu, 11 Oct 2018 18:15:53 -0400 2018-10-11T04:00:00-04:00 2018-10-11T05:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Analytical 3rd Year Student Seminars (October 12, 2018 4:00pm) https://events.umich.edu/event/54984 54984-13662980@events.umich.edu Event Begins: Friday, October 12, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry








Kunal Khanna(Walter Lab) , Shane Wells(Kennedy Lab)

]]>
Other Fri, 12 Oct 2018 18:15:50 -0400 2018-10-12T16:00:00-04:00 2018-10-12T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: "Carbonaceous nanoparticle and biological membrane - a molecular dynamic perspective" (October 12, 2018 4:00pm) https://events.umich.edu/event/53433 53433-13381402@events.umich.edu Event Begins: Friday, October 12, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: Nanoparticles have been widely utilized in many health-related fields, such as drug delivery, cancer therapy, biolabeling, and biosensors. Studies on the molecular details of the interaction between nanoparticles and biological nanosystems are crucial for obtaining information on the mechanisms of the possible outcomes of these nanomaterials, such as cytotoxicity, biological accumulation, and long-term effects. In this talk, we will introduce a recent model that we are developing to help understand and predict the interaction between carbonaceous nanoparticles and biological membrane based on the molecular structural information. The model presents in detail how molecular properties of nanoparticles such as size, shape and chemical properties affect the organization of the nanoparticles in the membrane, as well how different components in the membrane affect the selectivity on nanoparticles. This critical information is helpful for designing engineered nanoparticles that are biocompatible, bioavailable for different environmental and biological applications.

]]>
Workshop / Seminar Fri, 28 Sep 2018 11:27:26 -0400 2018-10-12T16:00:00-04:00 2018-10-12T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Desmond Liu
Moving beyond Methionine Synthase: New Insights into Cobalamin-Dependent Methyltransferase Reactions (October 15, 2018 4:00pm) https://events.umich.edu/event/51068 51068-11953412@events.umich.edu Event Begins: Monday, October 15, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Biological methylation underpins myriad cellular processes through the modification of proteins, lipids, nucleic acids, heavy metals, and a variety of small organic molecules. In the vast majority of these reactions, the appended methyl group derives from S-adenosylmethionine (SAM) and is attached most often to nitrogen and oxygen nucleophiles through a polar SN2 mechanism, although carbon, sulfur, and a variety of other nucleophilic atoms also receive SAM-derived methyl groups. Recently, it has become apparent that SAM is used to methylate non-reactive carbon and phosphorus atoms by mechanisms involving radical intermediates. To date, these reactions are catalyzed exclusively by radical SAM enzymes, a superfamily of enzymes that use an iron-sulfur (Fe-S) cluster to catalyze a reductive cleavage of SAM to methionine and the potent oxidant 5’-deoxyadenosin 5’-radical (5’-dA•). There are at least five subclasses of radical SAM methylases. Class B methylases represent the largest subclass, and use cobalamin to methylate both sp2- and sp3-hybridized carbon centers or phosphinate phosphorus centers during the biosynthesis of numerous biomolecules, including natural products with antibiotic and anticancer activities. This lecture will focus on two Class B radical SAM methylases involved in the biosynthesis of antibacterial agents. Fom3, which performs a key step in the biosynthesis of the broad-spectrum antibiotic fosfomycin, catalyzes the methylation of the sp3-hybridized C2’’ carbon of cytidylyl-2-hydroxyethylphosphonate to yield cytidylyl-2-hydroxypropylphosphonate. By contrast, TsrM catalyzes the first committed step in the biosynthesis of the quinaldic acid moiety of the thiopeptide antibiotic thiostrepton, which is the methylation of the sp2-hybridized C2 carbon of the indole ring of L-tryptophan. As will be discussed, while both Fom3 and TsrM are cobalamin-dependent radical SAM methylases, they use two distinctly different strategies to catalyze their reactions.














Squire Booker (The Pennsylvania State University)

]]>
Other Mon, 15 Oct 2018 18:15:46 -0400 2018-10-15T16:00:00-04:00 2018-10-15T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Understanding spliceosome mechanism with small molecule inhibitors (October 16, 2018 4:00pm) https://events.umich.edu/event/51622 51622-12173406@events.umich.edu Event Begins: Tuesday, October 16, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The spliceosome is the cellular machinery responsible for removing introns from gene transcripts by the process of splicing, and a variety of cancers accumulate specific mutations that alter spliceosome activity. In particular, the spliceosome protein SF3B1, which helps identify the boundary of introns, is frequently mutated in hematologic cancers. Notably, SF3B1 is also the common target of several bacterial natural products that were first identified in screens for drugs that kill cancer cells. We are investigating the structure-activity relationships of three different classes of SF3B1 inhibitors. Some analogs that are inactive for splicing inhibition nevertheless compete with their active counterparts, which suggests that drug binding alone is not sufficient to interfere with splicing. Furthermore, the competition of inactive and active compounds holds between different classes of inhibitors, supporting shared pharmacophores. We are now using these compounds as tools to explore the role of SF3B1 in splice site identification and fidelity, as well as in structural transitions required for spliceosome assembly.












Melissa Jurica (UC Santa Cruz)

]]>
Other Tue, 16 Oct 2018 18:15:46 -0400 2018-10-16T16:00:00-04:00 2018-10-16T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Analytical 3rd Year Student Seminars (October 17, 2018 4:00pm) https://events.umich.edu/event/54985 54985-13662981@events.umich.edu Event Begins: Wednesday, October 17, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Colleen Riordan(Bailey Lab) , Shannon Wetzler(Bailey Lab)

]]>
Other Wed, 17 Oct 2018 18:15:47 -0400 2018-10-17T16:00:00-04:00 2018-10-17T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Converting Anti-Aromatic to Aromatic: A Method to Access Boron-Containing Heteroarenes (October 18, 2018 12:00pm) https://events.umich.edu/event/55724 55724-13777498@events.umich.edu Event Begins: Thursday, October 18, 2018 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The concept of inorganic doping by substituting boron and a lone-pair bearing heteroatom in place of a C=C unit in carbon-based aromatics is an attractive method to alter the electronic properties. Our group has been working on developing a facile route to access inorganic/organic hybrid aromatic species via ring insertion reactions with anti-aromatic BC4 heterocycles, namely boroles. The insertion chemistry has been effective for the preparation of 1,2-azaborine, 1,2-phoaphaborine, 1,2-oxaborine, and 1,2-thiaborine heteroarenes which all have lower band gaps, red-shifted absorbances, and larger dipole moments in comparison to their carbonaceous counterpart, benzene. Ongoing efforts are focused on enhancing the electronic properties of these boracycles to explore their utility in electronic materials. Our current strategy is to extend conjugation in the inorganic/organic hybrid arenes by utilizing borole-based starting materials with conjugation installed. The mechanisms of these reactions and properties of the boracycles will be discussed.






Caleb Martin (Baylor University)

]]>
Other Thu, 18 Oct 2018 18:15:47 -0400 2018-10-18T12:00:00-04:00 2018-10-18T13:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
EEB Thursday Seminar: Trait-based approaches to plankton ecology & evolution (October 18, 2018 12:00pm) https://events.umich.edu/event/49651 49651-11487536@events.umich.edu Event Begins: Thursday, October 18, 2018 12:00pm
Location: Chemistry Dow Lab
Organized By: Ecology and Evolutionary Biology

NOTE TIME & LOCATION CHANGE

Abstract
Trait-based approaches are increasingly seen as a way to reduce the complexity of ecological communities and to incorporate functional diversity in ecosystem models. In this talk I will present Elena Litchman's and my lab's work applying trait-based ideas to marine and freshwater plankton communities. First, I will describe empirical patterns in the resource utilization and thermal traits we found using meta-analyses of published eco-physiological traits. Second, I will discuss trait-based approaches to modeling ecological and eco-evolutionary dynamics and how they can enhance our understanding of community structure in heterogeneous environments. Finally, I will describe recent theory on how local selection and immigration from the regional species pool interact to determine distribution of commonness and rarity in ecological communities and an experimental test.

]]>
Lecture / Discussion Fri, 12 Oct 2018 09:38:16 -0400 2018-10-18T12:00:00-04:00 2018-10-18T13:00:00-04:00 Chemistry Dow Lab Ecology and Evolutionary Biology Lecture / Discussion graph of space, time and trait
"Development of New Catalytic Reactions Involving the Activation of Traditionally Inert Bonds" (October 19, 2018 4:00pm) https://events.umich.edu/event/52879 52879-13094886@events.umich.edu Event Begins: Friday, October 19, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Organic molecules contain a variety of chemical bonds. Organic synthesis involves the cleavage of a chemical bond and the formation of a new chemical bond. However, not all of the chemical bonds in organic molecules have been used in organic synthesis. Thus, organic synthesis is heavily dependent on the reactivity of chemical bonds. If so-called unreactive bonds were to be used directly in organic synthesis, new possibilities for developing new synthetic methodologies would arise. We have utilized, not only the activation of C-H bonds, but also the activation of unreactive single bonds, such as C-C, C-O, C-N, and C-F bonds, and the activation of C-C triple bonds and C-O double bonds, in our quest to develop new types of transformations that will lead to further diversification in the field of organic synthesis.
















Naoto Chatani (Osaka University)

]]>
Other Fri, 19 Oct 2018 18:15:48 -0400 2018-10-19T16:00:00-04:00 2018-10-19T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: “Protons to patients: evaluating the role of the chloride transporter ClC-7 in lysosomal function” (October 19, 2018 4:00pm) https://events.umich.edu/event/53434 53434-13381403@events.umich.edu Event Begins: Friday, October 19, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: Lysosomes are essential focal points of cellular metabolism, digesting a wide range of macromolecules provided by endocytosis or autophagy. To this end, lysosomes rely on their highly acidic luminal pH to promote the function of their many enzymes, a pH generated by the action of a v-Type proton pumping ATPase. Since this transporter is electrogenic, parallel ion movements must occur to dissipate the generated membrane potential and promote bulk proton flux. I will present evidence that the Cl-/H+ antiporter, ClC-7, plays this role, moving Cl- to dissipate the lysosomal transmembrane voltage. However, the function of ClC-7 has been controversial, with conflicting reports on its contribution to lysosomal acidification. All heretofore known patients with ClC-7 functional mutations have varying degrees of the same disease, with osteopetrosis sometimes associated with lysosomal storage disease. Here, we report on two patients with a novel disease manifested as widespread lysosomal dysfunction but no bone abnormalities, who both have the same missense mutation in ClC-7. We find that fibroblasts from both patients have acidification abnormalities and that heterologously expressed human ClC-7 carrying this mutation displays a novel phenotype under electrophysiological measurements. These findings provide strong support for an important role of ClC-7 in the lysosomal acidification process and suggest opportunities for therapies for these patients.

]]>
Workshop / Seminar Wed, 26 Sep 2018 15:30:54 -0400 2018-10-19T16:00:00-04:00 2018-10-19T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Joe Mindell
GSK Info Session (October 22, 2018 11:15am) https://events.umich.edu/event/56687 56687-13963071@events.umich.edu Event Begins: Monday, October 22, 2018 11:15am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Beth Knapp-Reed, PhD

]]>
Workshop / Seminar Mon, 22 Oct 2018 18:15:46 -0400 2018-10-22T11:15:00-04:00 2018-10-22T12:15:00-04:00 Chemistry Dow Lab Department of Chemistry Workshop / Seminar Chemistry Dow Lab
Ozone, Carbon Dioxide, and Unusual Kinetic Isotope Effects: From the Stratosphere to the Laboratory and Back Again (October 22, 2018 4:00pm) https://events.umich.edu/event/53008 53008-13181201@events.umich.edu Event Begins: Monday, October 22, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The discovery of unusual oxygen isotope compositions in ozone and carbon dioxide by Mauersberger and co-workers and Thiemens and co-workers in the 1980s and 1990s has been followed by the challenges of understanding the chemical physics of the non-standard kinetic isotope effects on a molecular level and how they play out on a global scale, with the promise of providing new isotopic tracers of ozone production and transport in the stratosphere and the rates of uptake of atmospheric carbon dioxide by the biosphere. In this talk, I will highlight laboratory experiments (including crossed molecular beam experiments on O+O2 and O+CO2 and bulk photochemistry experiments on CO2 and O2 mixtures) and new stratospheric isotope measurements on air collected by aircraft and balloon flights that provide new insight into and constraints on the chemical physics of these unusual isotope effects needed to support their growing application to solving problems in the Earth and environmental sciences across a variety of disciplines.










Kristie Boering (University of California Berkeley)

]]>
Other Mon, 22 Oct 2018 18:15:46 -0400 2018-10-22T16:00:00-04:00 2018-10-22T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Analytical 3rd Year Student Seminars (October 24, 2018 4:00pm) https://events.umich.edu/event/54986 54986-13662982@events.umich.edu Event Begins: Wednesday, October 24, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Emily Mordan(Bailey Lab) , Kelcie Zegalia(Kennedy Lab)

]]>
Other Wed, 24 Oct 2018 18:15:48 -0400 2018-10-24T16:00:00-04:00 2018-10-24T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Incorporation of Fluorescent Dye Molecules into Molecular Scaffolds: From Molecular Sensors to Switchable Catalysts (October 24, 2018 4:00pm) https://events.umich.edu/event/55302 55302-13716035@events.umich.edu Event Begins: Wednesday, October 24, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Increased environmental and impurity restrictions on consumer products, also the desire to reduce the cost and energy requirements of chemical transformations, have established a critical need for the development of more selective and efficient catalysts. An attractive approach to addressing this need is the use of catalysts that can be altered through post-synthetic modifications. Several commonly employed methods to change catalyst reactivity post-synthesis include the manipulation of pH, photoactivation, or even changes in solvent. This talk will discuss the synthesis, characterization, and reactivity of fluorescent dye-containing main group compounds that are capable of exhibiting a colorimetric response upon binding substrate molecules. This talk will also describe the incorporation of fluorescent dye-containing ligands into metal and main group complexes for switchable reactivity.
















Zachariah Heiden (Washington State University)

]]>
Other Wed, 24 Oct 2018 18:15:48 -0400 2018-10-24T16:00:00-04:00 2018-10-24T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
C-H and C-O functionalization via radical chaperones (October 25, 2018 4:00pm) https://events.umich.edu/event/52741 52741-12986895@events.umich.edu Event Begins: Thursday, October 25, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our research is focused on harnessing the untapped reactivity of cheap and abundant chemical feedstocks in organic synthesis to enable the late-stage functionalization of complex natural products and other medicinally-relevant molecules. We have recently developed new approaches for selective C-H and C-O functionalization of alcohols and carbonyls, using a combination of radical (1e-) and closed shell (2e-) processes that act in concert with one another. These new radical chaperone strategies have enabled the development of chemical transformations with applications within molecules of biological and industrial interest.










David Nagib (The Ohio State University)

]]>
Other Thu, 25 Oct 2018 18:15:46 -0400 2018-10-25T16:00:00-04:00 2018-10-25T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Analytical 3rd Year Student Seminars (October 26, 2018 4:00pm) https://events.umich.edu/event/54987 54987-13662983@events.umich.edu Event Begins: Friday, October 26, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Cole Chapman(Bailey Lab) , John Orlet(Bailey Lab)

]]>
Other Fri, 26 Oct 2018 18:15:46 -0400 2018-10-26T16:00:00-04:00 2018-10-26T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: "The ParA/MinD family of ATPases make waves to position DNA, cell division, and organelles in bacteria" (October 26, 2018 4:00pm) https://events.umich.edu/event/56105 56105-13832575@events.umich.edu Event Begins: Friday, October 26, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: Positional information in eukaryotic cells is mainly orchestrated by cytoskeletal highways and their associated motor proteins like Myosin, Kinesin, and Dynein. Bacteria don’t have linear motors, so how are they spatially organized? I will be discussing three members of the ParA/MinD family of ATPases that are part of self-organizing systems that put things in their place in cells across the microbial world. I will first present the ATPase called ParA, which is part of the most common DNA-segregation system in bacteria. ParA proteins form dynamic waves on the nucleoid to position chromosomes and plasmids in opposite cell-halves so that they are faithfully inherited after cell division. I will then discuss the ATPase called MinD, which is part of a system that forms oscillatory waves on the inner membrane. The oscillation aligns cell division at mid-cell so that daughter cells are equal in size. Finally, I will introduce a new member of this ATPase family we call McdA, which is part of an organelle trafficking system in bacteria. Yes. Bacteria have organelles. Our work is shedding light on what seems to be a general mode of subcellular organization in bacteria – dynamic protein gradients surfing biological surfaces to impart positional information for a wide variety of fundamental biological processes. My new lab focuses on subcellular organization in bacteria with a strong emphasis towards reconstituting the self-organizing activities of these systems in a cell-free setup using purified and fluorescent labeled components. By visualizing the biochemistry driving self-organization outside the cell we are able to provide comprehensive molecular mechanisms that explain subcellular organization inside the cell.

]]>
Workshop / Seminar Tue, 02 Oct 2018 16:14:04 -0400 2018-10-26T16:00:00-04:00 2018-10-26T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Anthony Vecchiarelli
Ultrafast Studies of Single Plasmonic Nanostructures (October 26, 2018 4:00pm) https://events.umich.edu/event/54352 54352-13574513@events.umich.edu Event Begins: Friday, October 26, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The optical properties of metal nanostructures are dominated by plasmon resonances, which are strong collective motions of the conduction electrons. These resonances are at the heart of a variety of schemes for molecular sensing and plasmon enhanced catalysis. However, the dynamics of plasmons can be difficult to study due to the distribution of particle sizes and shapes present in typical samples. In this talk I will describe single particle experiments that provide information about the ultrafast energy relaxation processes of plasmonic nanostructures, and how these structures interact with their environment. Examples of the processes that have been studied include the creation of novel hybrid states through coupling between plasmons and excitons, and the strange case of viscoelastic effects in the damping of vibrational modes of metal nanostructures.










Gregory Hartland (University of Notre Dame)

]]>
Other Fri, 26 Oct 2018 18:15:45 -0400 2018-10-26T16:00:00-04:00 2018-10-26T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Chemistry - Biology Interface Training Program Symposium (October 30, 2018 1:00pm) https://events.umich.edu/event/56808 56808-14008216@events.umich.edu Event Begins: Tuesday, October 30, 2018 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry








Tarun Kapoor

]]>
Other Tue, 30 Oct 2018 18:15:42 -0400 2018-10-30T13:00:00-04:00 2018-10-30T18:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Chemistry at the Intersection of Self-Assembly and Energy Conversion (October 30, 2018 4:00pm) https://events.umich.edu/event/52611 52611-12901950@events.umich.edu Event Begins: Tuesday, October 30, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry



Nature uses a complex array of chromophores, optimally organized both spatially and electronically, to carry out photoinduced energy and electron transfer from pigment molecules to a reaction center. The fundamental processes underpinning photosynthesis provide the basis for artificial solar conversion systems that include photovoltaic cells, photoanodes and photocathode catalysts to generate electricity or fuels. It is the supramolecular arrangement of multiple chromophores that results in the emergent properties associated with natural light harvesting complexes, including enhanced absorption, efficient energy transfer between pigments, and electron-transfer. We are interested in self-assembled discrete metal-organic assemblies containing multiple chromophores as functional models of supramolecular light harvesting architectures. Specifically, we are actively designing systems to identify the optimal alignment, spacing, and electronic structure to enable directional EnT and photoredox chemistry while maximizing broadband absorption matched to the solar flux. The formation of structurally complex metal-organic polygons, polyhedra, and prisms (MOPs) is greatly facilitated by coordination-driven self-assembly methods which furnish them in single, one-pot reactions. An ever-growing library of organic ligands (donors) and metal/organometallic complexes with substitutionally labile coordination sites (acceptors) serves as the basis for a suite of metallacycles and cages characterized by their well-defined internal cavities and predictable topologies. The rigid organic backbones that once served solely as structural elements have more recently been exploited for their ability to impart interesting photophysical properties to their parent MOPs. Strategies include tethering pendant fluorophores through covalent coupling chemistry and selecting inherently emissive building blocks, with an emphasis on exploiting Ru, Ir, and Pt-based complexes.








Timothy Cook (University of Buffalo)

]]>
Other Tue, 30 Oct 2018 18:15:42 -0400 2018-10-30T16:00:00-04:00 2018-10-30T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Analytical 3rd Year Student Seminars (October 31, 2018 4:00pm) https://events.umich.edu/event/54988 54988-13662984@events.umich.edu Event Begins: Wednesday, October 31, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Bonsall Robert(McCrory Lab) , Geng Luqan(Kennedy Lab)

]]>
Other Wed, 31 Oct 2018 18:15:41 -0400 2018-10-31T16:00:00-04:00 2018-10-31T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Undergraduates Teaching Chemistry Through Outreach (November 2, 2018 12:00pm) https://events.umich.edu/event/53786 53786-13461543@events.umich.edu Event Begins: Friday, November 2, 2018 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Ellen Yezierski (Miami University)

]]>
Other Fri, 02 Nov 2018 18:15:42 -0400 2018-11-02T12:00:00-04:00 2018-11-02T00:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Innovative Strategies for Nonconventional Water Splitting and Beyond (November 2, 2018 4:00pm) https://events.umich.edu/event/53785 53785-13461542@events.umich.edu Event Begins: Friday, November 2, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

One of the challenges to realize large-scale H2 production from water electrolysis is the lack of competent and inexpensive electrocatalysts. Our group recently discovered that surface modification of metallic nickel with nitrogen resulted in a superior electrocatalyst for H2 evolution under neutral condition, rivaling the performance of the state-of-the-art platinum-based catalysts. In addition, since water oxidation is more kinetically challenging while its product O2 is not of significant value, we are also interested in exploring alternative oxidation reactions which can not only provide electrons for H2 evolution at the cathode but also yield value-added organic products at the anode. Within this context, biomass-derived intermediate compounds are found to be suitable candidates for electrocatalytic upgrading, which can be integrated with H2 production under alkaline conditions. Finally, a new electrolyzer design for decoupled water splitting and organic transformation will be presented, which is able to substantially reduce voltage inputs and mitigate the H2/O2 mixing issue commonly encountered in conventional water electrolysis.












Yujie Sun (University of Cincinnati)

]]>
Other Fri, 02 Nov 2018 18:15:41 -0400 2018-11-02T16:00:00-04:00 2018-11-02T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Titles: "Quantitative analysis of the spindle assembly checkpoint (SAC)", Chu Chen and "Pattern Formation in 2D Tissues via Mechanics: From Juvenile Zebrafish to Human Embryonic Stem Cells", Hayden Nunley (November 2, 2018 4:00pm) https://events.umich.edu/event/53435 53435-13381404@events.umich.edu Event Begins: Friday, November 2, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstracts:
Chu Chen - In mammalian cells, accurate chromosome segregation during mitosis requires that kinetochores of sister chromatids attach to microtubules emanating from opposite spindle poles. In the absence of kinetochore-microtubule attachment, the spindle assembly checkpoint (SAC) is activated to delay anaphase onset. Over the past two decades, researchers have basically revealed the fundamental biochemical pathway of SAC signaling. However, how SAC effectively halts mitosis progression in the presence of very few unattached kinetochores is less addressed. In this talk, quantitative evidence will be presented which suggest the presence of synergistic actions in SAC. Hypothesis about the underlying mechanism and preliminary data from ongoing validation experiments will also be discussed. This cooperativity may enable a single unattached kinetochore to produce a strong enough signal.-

and

Hayden Nunley - Many epithelial tissues are composed of several types of cells with distinct functions. For proper functioning of the tissues, it is often important that the different types of cells form a spatial pattern. The specific biological details of how the cells interact to form these patterns are often not fully understood. To study the developmental processes in the absence of detailed biological information, it is useful to test which simplified physical models are consistent with experimental observations. With insights from these models, we identify specific candidate proteins or cellular structures necessary for the interaction, and generate predictions of how specific manipulations will affect tissue patterning. In this spirit, we will discuss the formation of a crystal of cone photoreceptors in juvenile zebrafish retinae. We find that the structure and arrangement of defects in the tissue are consistent with a purely mechanical model in which cones of one specific type interact with other cones of the same type at short range. We identify a specific cellular structure as a candidate for mediating this interaction. We will also discuss neural fate specification in human embryonic stem cell colonies. To study this pattern which has a length scale that does not scale with colony size, we propose a model in which cells respond to mechanical stresses by altering their contractility.

]]>
Workshop / Seminar Tue, 16 Oct 2018 11:24:41 -0400 2018-11-02T16:00:00-04:00 2018-11-02T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
John Essigmann Panel Discussion (November 5, 2018 4:00pm) https://events.umich.edu/event/53083 53083-13222317@events.umich.edu Event Begins: Monday, November 5, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry
















John Essigmann (Massachusetts Institute of Technology)

]]>
Other Mon, 05 Nov 2018 18:15:39 -0500 2018-11-05T16:00:00-05:00 2018-11-05T18:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Unconventional Building Blocks for Functional Polymeric Materials (November 6, 2018 4:00pm) https://events.umich.edu/event/52163 52163-12502488@events.umich.edu Event Begins: Tuesday, November 6, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The Klausen group designs and synthesizes unconventional molecular building blocks
for the construction of diverse functional polymeric architectures. Motivated by the conviction that the synthesis of new materials drives the discovery of new applications, this talk will describe the synthesis and polymerization of novel hybrid inorganic-organic monomers. The materials we prepare are expected to find application in energy science as earth abundant quantum materials or as plastics with finely controlled physical properties.
The semiconductor silicon has revolutionized life in the last century, from the development of computer chips to the discovery of solar cells that make telecommunication satellites possible. The frontier for silicon research and development is at the nanoscale. The incredible potential of nanoscale silicon arises from the attractive properties it shares with bulk silicon, such as earth abundance and low precursor toxicity, and the distinctive optical and electronic properties emerging at small sizes. This talk describes the design and synthesis of new molecular forms of silicon, as well as the characterization of materials properties and the fabrication of electronic devices based on molecular silicon.
BN 2-Vinylnaphthalene (BN2VN) is a solution to a long-standing challenge in polymer chemistry, the copolymerization of nonpolar and polar monomers. Though the incorporation of polar functionality into nonpolar polymers is an essential strategy for modulating physical properties, challenges in their direct copolymerization include phase separation, significant differences in reactivity, and the limited compatibility of polar functional groups with polymerization catalysts. We show that BN2VN retains the reactivity of styrene, while post- polymerization modification of the C-B bond provides hydroxyl-functionalized polymers, or styrene-vinyl alcohol (SVA) copolymers.


















Bekka Klausen (Johns Hopkins University)

]]>
Other Tue, 06 Nov 2018 18:15:40 -0500 2018-11-06T16:00:00-05:00 2018-11-06T17:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Organizational Studies Info Night! (November 6, 2018 5:30pm) https://events.umich.edu/event/55542 55542-13756887@events.umich.edu Event Begins: Tuesday, November 6, 2018 5:30pm
Location: Chemistry Dow Lab
Organized By: Organizational Studies Program (OS)

Want to learn more about Organizational Studies?

Join us to hear more about this interdisciplinary major based in social sciences where students customize their own education. Enjoy a small community of dedicated and ambitious students with access to top-notch faculty and an engaged alumni network. You'll have the opportunity to hear from the Program Director, Major Advisor, Prospective Student Advisors, and a diverse panel of OS students!

Visit our website in the meantime for more information on the curriculum, application, or to sign-up for a prospective student advising meeting.

Follow us on Facebook to engage with our community and stay up-to-date with OS happenings!

]]>
Meeting Tue, 18 Sep 2018 11:15:27 -0400 2018-11-06T17:30:00-05:00 2018-11-06T19:00:00-05:00 Chemistry Dow Lab Organizational Studies Program (OS) Meeting OS
Symmetry Making and Breaking in Seeded Growth of Metal Nanocrystals (November 8, 2018 4:00pm) https://events.umich.edu/event/52487 52487-12809234@events.umich.edu Event Begins: Thursday, November 8, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Crystal growth theory predicts that heterogeneous nucleation will occur preferentially at defect sites, such as the vertices rather than the faces of shape-controlled seeds. Platonic metal solids are generally assumed to have vertices with nearly identical chemical potentials, and also nearly identical faces, leading to the useful generality that heterogeneous nucleation preserves the symmetry of the original seeds in the final product. This presentation will discuss how this generality can be used to access stellated metal nanocrystals with high and tunable symmetries for applications in plasmonics. This presentation will also discuss the limits of this generality in the extreme of low supersaturation. A strategy for favoring localized deposition that differentiates between both different vertices and different edges or faces, i.e., regioselective deposition, will be demonstrated. Such regioselective heterogeneous nucleation was achieved at low supersaturation by a kinetic preference for high-energy defect-rich sites over lower-energy sites. This outcome was enhanced by using capping agents to passivate facet sites where deposition was not desired. Collectively, the results presented provide a model for breaking the symmetry of seeded growth and for achieving regioselective deposition.






















Sara Skrabalak (Indiana University)

]]>
Other Thu, 08 Nov 2018 18:15:44 -0500 2018-11-08T16:00:00-05:00 2018-11-08T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Active Learning Strategies Lunch Series (November 9, 2018 11:30am) https://events.umich.edu/event/57220 57220-14130947@events.umich.edu Event Begins: Friday, November 9, 2018 11:30am
Location: Chemistry Dow Lab
Organized By: Instructional Support Services

Join us for an informal gathering in one of LSA's team-based learning (TBL) classrooms, CHEMISTRY A859, for lunch and a lively discussion about a variety of topics related to teaching. This session will focus on managing student group dynamics. Lunch is provided.

]]>
Workshop / Seminar Tue, 30 Oct 2018 14:48:30 -0400 2018-11-09T11:30:00-05:00 2018-11-09T12:30:00-05:00 Chemistry Dow Lab Instructional Support Services Workshop / Seminar Active Learning Strategies Lunch Series
Seminar Title: “Discovering a new broad antiviral inhibitor” (November 9, 2018 4:00pm) https://events.umich.edu/event/53438 53438-13381407@events.umich.edu Event Begins: Friday, November 9, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: The human ESCRT protein machinery is required for membrane remodeling events including multivesicular body biogenesis, cellular abscission, and viral budding. Specifically, the Pro-Thr-Ala-Pro (PTAP) motif of viral Gag proteins targets the ESCRT-I complex via a direct interaction with Tsg101 (tumor susceptibility gene 101). This interaction is necessary for the viral Gag proteins to be recruited to the membrane. Naturally this interaction site has been the target for designing anti-viral drugs by mimicking the PTAP motif. Recently we identified a small molecule inhibitor of HIV budding, which we expected to bind to the PTAP recognition site of Tsg101. This molecule belongs to a family of proton pump inhibitors that are clinically used to treat acid reflux. Initial characterization using solution NMR indicated that the inhibitor interacts with Tsg101 outside of the PTAP recognition site. The structure of Tsg101 and a small molecule inhibitor complex that we solved reveals a covalent interaction occurring at the ubiquitin (Ub) binding site of Tsg101. Tsg101’s main contribution to ESCRT-I function is in recognition of and binding to Ub-modified cargo. The fact that the inhibitor targeted ubiquitin-Tsg101 binding was significant, since this interaction was previously thought to have little influence on the HIV-1 life cycle. Using our new inhibitor as a tool, we uncovered the essential role of Ub-Tsg101 interaction to promote degradation of HIV-1 Gag protein in the cell and to block co-localization of Tsg101 and HIV-1 Gag at the plasma membrane required for budding. In addition, we also showed that Tsg101 has another binding site that can contact the second Ub moiety in K48 or K63 linked di-Ub molecules. This second Ub binding site on Tsg101 has a weaker affinity compared to the first site and its observation required the use of novel NMR methodology. Our recent results show the potential for development of broad spectrum antiviral inhibitor based on clinically approved proton pump inhibitors targeting Tsg101 and we also provided the first evidence for the important role of Tsg101 and di-Ub interaction in viral replication.

]]>
Workshop / Seminar Wed, 03 Oct 2018 11:43:15 -0400 2018-11-09T16:00:00-05:00 2018-11-09T17:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Nico Tjandra
RNA tertiary structure and its role in molecular recognition: lessons from self-splicing group II introns and lncRNA molecules. (November 12, 2018 4:00pm) https://events.umich.edu/event/50829 50829-11876205@events.umich.edu Event Begins: Monday, November 12, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The vast majority of our gene products are noncoding RNA molecules, many of which have elaborate three-dimensional structures. Despite the importance of RNA tertiary structure in gene expression, the scope of our knowledge about RNA structure and molecular recognition is limited. This is largely due to the small number of high resolution RNA structures and a paucity of studies on small molecule recognition by RNA. To address this problem, we have focused on understanding the molecular architecture and catalytic mechanism of group II introns, which are RNAs that catalyze their own splicing. We have also used the catalytic activity of group II introns to carry out high throughput screening of small molecule inhibitors, which we have optimized and developed as antifungal agents. These studies have been complemented by parallel studies on other long noncoding RNAs that lack catalytic activity, with the goal of identifying approaches for understanding and targeting RNA tertiary structures within the large network of regulatory lncRNAs.








Anna Marie Pyle (Yale University)

]]>
Other Mon, 12 Nov 2018 18:15:39 -0500 2018-11-12T16:00:00-05:00 2018-11-12T17:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: "Synthesis and Electrochemical Characterization of Magnesium-Ion Battery Electrolytes" (November 14, 2018 2:00pm) https://events.umich.edu/event/57255 57255-14142072@events.umich.edu Event Begins: Wednesday, November 14, 2018 2:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Adam Crowe (Advisor: Prof. Bart M. Bartlett)

]]>
Other Wed, 14 Nov 2018 18:15:37 -0500 2018-11-14T14:00:00-05:00 2018-11-14T15:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Hydrocarbon Functionalization in Porous Materials (November 15, 2018 4:00pm) https://events.umich.edu/event/57177 57177-14124206@events.umich.edu Event Begins: Thursday, November 15, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Hydrocarbons are cheap and abundant feedstocks readily derived from both fossil fuels and emerging renewable resources. Despite their abundance, hydrocarbons have limited applications in chemical synthesis due to the inertness of C–H bonds towards both homolytic and heterolytic bond cleavage. I will share two very different approaches to the selective functionalization of simple hydrocarbons that address these challenges. First, I will highlight a bio-inspired approach to achieve selective alkane hydroxylation using iron-based metal–organic frameworks. The critical influence of both primary and secondary coordination sphere elements on catalyst reactivity, selectivity, and stability will be detailed. Second, I will describe the identification and characterization of a simple heterogeneous base catalyst that converts aromatic hydrocarbons, CO2, and methanol into the corresponding aromatic esters at elevated temperatures. The transformation occurs via a two-step, semi-continuous cycle, and represents the first hydrocarbon CO2 insertion process that does not consume any energy-intensive stoichiometric reagents.






Dianne Xiao, PhD (Stanford University)

]]>
Other Thu, 15 Nov 2018 18:15:33 -0500 2018-11-15T16:00:00-05:00 2018-11-15T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Halogen Bonding in Single Electron Transfers to Initiate New Radical Reactions (November 16, 2018 4:00pm) https://events.umich.edu/event/53007 53007-13179050@events.umich.edu Event Begins: Friday, November 16, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Non-covalent halogen bonding has been utilized in biological systems to increase the binding affinities of synthetic drugs to receptor sites in the body. These weak interactions typically mimic hydrogen bonding but offer a hydrophobic alternative to the typical polar or charged groups that are present in natural biological systems. Recently, our lab has identified halogen bonding as an important feature of electron-transfer for initiating certain radical reactions. We have strong preliminary experimental and computational evidence demonstrating the importance of halogen bonding in the context of radical fluorination, and believe a generalized strategy may be applied to a wide range of free radical reactions including heteroarene alkylation and arylation.









Ryan Baxter (University of California at Merced)

]]>
Other Fri, 16 Nov 2018 18:15:35 -0500 2018-11-16T16:00:00-05:00 2018-11-16T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: Unraveling the enigma of the translocator protein 18kD, TSPO. (November 16, 2018 4:00pm) https://events.umich.edu/event/53439 53439-13381408@events.umich.edu Event Begins: Friday, November 16, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract:
The precise physiological roles of the ancient and conserved membrane protein TSPO (otherwise known as the translocator protein 18kD or the peripheral benzodiazepine receptor) remain obscure. The original discovery of TSPO in mammals occurred when it was found as an additional binding site for benzodiazepine drugs. High expression in tissues involved in steroid hormone synthesis along with other evidence suggested a regulatory role in cholesterol uptake into mitochondria, especially under stress conditions. More recently, TSPO knockout mouse models show inconsistent characteristics that weaken this hypothesis, although some common features exist: the loss of TSPO increased lipid oxidation, decreased ATP synthesis and decreased mitochondrial membrane potential. Another common feature of TSPO across all kingdoms appears to be the ability to bind porphyrins, including heme and protoporphyrin IX, likely endogenous ligands. Yet despite decades of research, there is no consensus regarding the nature and mechanism of TSPO effects. In this talk, I will discuss the current state of the structural, biochemical, and physiological analyses that are beginning to reveal how TSPO functions.

]]>
Workshop / Seminar Thu, 08 Nov 2018 14:14:53 -0500 2018-11-16T16:00:00-05:00 2018-11-16T17:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Michael Garavito
Thesis Defense: "Development of Strategies for the Synthesis of Heterocycles and Carbocycles; and Investigation of Chemistry Course Placement on Undergraduate Students" (November 19, 2018 1:00pm) https://events.umich.edu/event/57256 57256-14142073@events.umich.edu Event Begins: Monday, November 19, 2018 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Elsa Hinds (Advisor: Prof. John P. Wolfe)

]]>
Other Mon, 19 Nov 2018 18:15:30 -0500 2018-11-19T13:00:00-05:00 2018-11-19T14:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Catalytic Manipulation of Reactivity and Selectivity at High-Valent Nuclei (November 19, 2018 4:00pm) https://events.umich.edu/event/57146 57146-14121949@events.umich.edu Event Begins: Monday, November 19, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

This presentation will examine aspects of reactivity and selectivity discovered through the exploration of the chemistry of high-valent nuclei [Au(III), Pt(IV), and I(III)]. The first part concerns two examples wherein transition metals are examined as substrates for catalytic reactions rather than in their traditional role as catalysts. Operating from this perspective, supramolecular catalysis of C(sp3)-C(sp3) reductive elimination and organoborane catalyzed C(sp3)-CF3 reductive elimination will be discussed, with the latter applied to [18F]-radiotrifluoromethylation. The second section will continue the focus on fluorination through the development of a new aryliodine catalyst for enantioselective olefin difluorination, exploring structural features that improve catalyst robustness and selectivity and enabling the preparation of chiral fluorinated building blocks.




Mark Levin, PhD (Harvard University)

]]>
Other Mon, 19 Nov 2018 18:15:30 -0500 2018-11-19T16:00:00-05:00 2018-11-19T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Roles of elusive translational GTPases (LepA and BipA) come to light (November 20, 2018 4:00pm) https://events.umich.edu/event/53787 53787-13461544@events.umich.edu Event Begins: Tuesday, November 20, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Protein synthesis relies on several translational GTPases (trGTPases), related proteins that couple the hydrolysis of GTP to specific molecular events on the ribosome. Most bacterial trGTPases, including IF2, EF-Tu, EF-G, and RF3, play well-known roles in translation. The cellular functions of LepA (also termed EF4) and BipA (also termed TypA), on the other hand, have remained enigmatic. I will discuss recent evidence that LepA and BipA function in biogenesis of the 30S and 50S subunit, respectively. These findings have important implications for ribosome biogenesis in bacteria.










Kurt Fredrick (The Ohio State University)

]]>
Other Tue, 20 Nov 2018 18:15:28 -0500 2018-11-20T16:00:00-05:00 2018-11-20T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
On the path to analytical utopia through the resolution of isomers by mass spectrometry (November 27, 2018 12:00pm) https://events.umich.edu/event/57538 57538-14211233@events.umich.edu Event Begins: Tuesday, November 27, 2018 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Advances in mass spectrometry over recent years have significantly improved the mass-resolving power of modern instrumentation and the speed with which high mass-accuracy data can be acquired. These advances have underpinned increased confidence in compound identification in complex mixtures and opened up entirely new means of data acquisition including the next generation of data-independent analytical workflows. While powerful, an inherent limitation in all these analytical approaches lies in the discrimination of isomers which, by definition, share the same elemental composition and thus the exact same mass. Conventional approaches to isomer discrimination have relied on chromatographic separations prior to mass analysis and tandem mass spectrometry however, this has proven a limited tool box for structurally similar isomers (e.g., regioisomers) and can significantly extend analysis times. Fortunately, exciting new developments in ion-mobility and ion-activation technologies are emerging to tackle the challenge of isomer-discrimination by mass spectrometry. This presentation will address the latest developments in these rapidly emerging technology areas in the context of lipidomic analysis with examples illustrating effective discrimination of regio- and even stereo-isomers.
















Stephen Blanksby (Queensland University of Technology)

]]>
Other Tue, 27 Nov 2018 18:15:31 -0500 2018-11-27T12:00:00-05:00 2018-11-27T13:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Main-Group Metallomimetics: Strategies for Metal-Free Catalysis and Small-Molecule Activation (November 27, 2018 4:00pm) https://events.umich.edu/event/57147 57147-14121950@events.umich.edu Event Begins: Tuesday, November 27, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The importance of transition metals (TMs) in modern catalysis cannot be overstated. TM-based catalysts enable processes that are of tremendous human and economic importance; they have innumerable applications in many industrial sectors. However, the toxicity, price and natural scarcity of many elements that are used in TM catalysis fuels an interest for the development of metal-free catalysts based on the main-group elements. However, contrary to many catalytically-active TM-complexes, classical main-group compounds do not possess the combination of empty and filled orbitals that is crucial for the complex electronic processes involved in the elemental steps of catalytic cycles. The development of catalysts based on the p-block elements thus requires the design and application of unique strategies. In this talk, I will present two approaches for the metallomimetic application of boron compounds to small-molecule activation, to reduction processes, and to organic functionalization reactions. I will discuss systems that involve the combination of single and multiple active sites in order to mimic the electronic environment of TM complexes. Similarities and differences in the reactivity of main-group compounds and TM complexes will also be highlighted.






















Marc-Andre Legare, PhD (Universitat Wurzburg)

]]>
Other Tue, 27 Nov 2018 18:15:31 -0500 2018-11-27T16:00:00-05:00 2018-11-27T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Spectroscopic characterization of unique iron and copper active sites in biology (November 29, 2018 4:00pm) https://events.umich.edu/event/57178 57178-14124207@events.umich.edu Event Begins: Thursday, November 29, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Iron and copper ions are ubiquitous in nature and serve a variety of important biological functions. My presentation will focus on the characterization of (1) the first biologically-relevant oxoiron(V) model complex and (2) a Cu/O2 intermediate in the mononuclear copper enzyme Formylglycine-Generating Enzyme (FGE). In both cases, we have been able to utilize spectroscopic insight to characterize novel, fleeting intermediates and to understand how they fit into proposed reaction mechanisms.

(1) Oxoiron(V) species are fleeting intermediates that are postulated to be involved in some of the most difficult oxidative transformations in biology. Using a biomimetic analog, we employed resonance Raman, electron paramagnetic resonance, and Mössbauer spectroscopies in conjunction with calibrated DFT computations to elucidate key structural and electronic properties. We were able to attribute its highly anisotropic hyperfine parameters and unusual spectroscopic features to an iron(V) complex with an axial oxo ligand. Our analysis defines spectroscopic parameters characteristic of perferryl intermediates in biology.

(2) Apart from its importance for sulfatase activity, FGE also serves as a powerful tool for protein engineering because of its ability to introduce aldehyde functional groups into recombinant proteins. Together with my collaborators, we have used high-energy X-ray techniques to spectroscopically define the unique copper active site in the absence and presence of its functional peptide substrate. Furthermore, we now have evidence for key intermediates along the O2-reaction pathway. With this crucial insight in hand, we have a more complete understanding of how FGE utilizes its unique mononuclear copper active site to activate O2, initiate reaction with substrate, and generate the Cα-formylglycine product.




Katlyn Meier, PhD. (Stanford University)

]]>
Other Thu, 29 Nov 2018 18:15:35 -0500 2018-11-29T16:00:00-05:00 2018-11-29T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: Advanced metabolomics analysis by NMR with lessons for protein interactions (November 30, 2018 4:00pm) https://events.umich.edu/event/53440 53440-13381409@events.umich.edu Event Begins: Friday, November 30, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: The rapid, reliable and comprehensive identification and quantitation of a large number
of organic molecules in complex mixtures, such as metabolites in biological systems in the context of metabolomics, will be discussed using multidimensional NMR tools. They include curated databases of known metabolites, multidimensional spectral query for identification and quantitation, and rapid non-uniformly sampled 2D TOCSY collection and spectral reconstruction. Many of these developments are now available for automation and have been integrated into our COLMAR suite of web servers and databases (http://spin.ccic.ohio-state.edu/index.php/colmar).

Physical-chemical properties of metabolites can also be obtained by quantitatively analyzing their interaction propensities with synthetic nanoparticles. Such information, in turn, can be applied to understand and predict interaction profiles of intrinsically disordered proteins (IDPs) with nanoparticle surfaces.

]]>
Workshop / Seminar Thu, 01 Nov 2018 08:55:42 -0400 2018-11-30T16:00:00-05:00 2018-11-30T17:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Rafael Bruschweiler
Anders Hansen (December 3, 2018 4:00pm) https://events.umich.edu/event/57179 57179-14124208@events.umich.edu Event Begins: Monday, December 3, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Mammalian genes are regulated by enhancers, which can be hundreds of kilobases to megabases away from the gene whose expression they control by forming chromatin loops. Understanding mammalian gene regulation therefore requires understanding 3D genome organization. We have developed new chemical biology, computational and biophysical approaches to visualize the key proteins, CTCF and cohesin, that control chromatin looping at single-molecule resolution inside living cells. Similarly, we have developed approaches to directly visualize chromatin loops and to follow them dynamically as they form, function, and break inside living cells. We will discuss our results from these studies, which suggest that 3D genome organization and chromatin loops are likely much more dynamic than previously anticipated.




Anders Hansen, PhD (UC Berkeley)

]]>
Other Mon, 03 Dec 2018 18:15:25 -0500 2018-12-03T16:00:00-05:00 2018-12-03T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Studies on student learning in a new organic chemistry curriculum designed to deepen understanding of reactivity and chemistry principles (December 6, 2018 4:00pm) https://events.umich.edu/event/57556 57556-14213443@events.umich.edu Event Begins: Thursday, December 6, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Chemistry education research has revealed numerous challenges students face learning organic chemistry, including barriers learning chemistry’s language, interpreting, rationalizing, and predicting mechanistic processes and driving forces, and limitations in curricula connecting organic chemistry to broader contexts. In this presentation, I will more deeply describe these challenges, explain our efforts at addressing these challenges with a redesigned curriculum, and share our associated research findings.












Alison Flynn (University of Ottawa)

]]>
Other Thu, 06 Dec 2018 18:15:27 -0500 2018-12-06T16:00:00-05:00 2018-12-06T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Active Learning Strategies Lunch Series (December 7, 2018 11:30am) https://events.umich.edu/event/57225 57225-14130950@events.umich.edu Event Begins: Friday, December 7, 2018 11:30am
Location: Chemistry Dow Lab
Organized By: Instructional Support Services

Join us for an informal gathering in one of LSA's team-based learning (TBL) classrooms, CHEMISTRY A859, for lunch and a lively discussion about a variety of topics related to teaching. This session will focus on simple in-class collaboration activities. Lunch is provided.

]]>
Workshop / Seminar Tue, 30 Oct 2018 14:47:50 -0400 2018-12-07T11:30:00-05:00 2018-12-07T12:30:00-05:00 Chemistry Dow Lab Instructional Support Services Workshop / Seminar Active Learning Strategies Lunch Series
“4D MAPPING OF SPATIOFUNCTIONAL ENZYME DROPLETS IN LIVING CELLS” (December 7, 2018 4:00pm) https://events.umich.edu/event/53441 53441-13381410@events.umich.edu Event Begins: Friday, December 7, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: The cytoplasmic, rate-determining enzymes in glucose metabolism are spatially organized into multienzyme assemblies in various sizes in human cells. They are proposed to shunt metabolic flux from glycolysis to anabolic biosynthetic pathways. However, how the formation of the enzyme assemblies and their sub-cellular locations in the cells are associated with their metabolic functions are largely unknown. In this work, we show that the enzyme assemblies in glucose metabolism are formed by liquid phase separation in a pathway specific manner. With 4D imaging using the home-built lattice light sheet microscope, we observe that the membraneless assemblies present liquid droplet properties. Moreover, we reveal that significant numbers of the enzyme assemblies are in proximity with mitochondria. We also monitor the reversible formation and spatial organization of the enzyme assembly upon the inhibition of mitochondrial metabolism. Our results shed light on how the enzyme assemblies are formed and positioned near cellular organelles to locally and efficiently orchestrate their metabolic functions. We envision that the presented “spatiofunctional” characteristics of the enzyme assemblies in glucose metabolism are an unprecedented starting point for mapping 4D functional metabolic network in live cells.

]]>
Workshop / Seminar Fri, 16 Nov 2018 14:24:37 -0500 2018-12-07T16:00:00-05:00 2018-12-07T17:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Minjoung Kyoung
Bringing Biochemistry into the Genomic Era (December 10, 2018 4:00pm) https://events.umich.edu/event/51012 51012-11941994@events.umich.edu Event Begins: Monday, December 10, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

High-throughput and quantitative biochemical approaches will be required to develop predictive models of cell function and regulation, and to understand systems as complex as enzymes. I will describe two such approaches and the insights attained to date. RNA-MaP developed by the Greenleaf lab at Stanford allows us to determine thermodynamic and kinetic rules for RNA binding by RNA binding proteins, and provides testable models for cellular RNA/protein interactions and additional biophysical and evolutionary insights. HT-MEK (High-throughput Mechanistic Enzyme Kinetics), a new microfluidics methodology developed by the Fordyce lab at Stanford, allows us to obtain quantitative kinetic and thermodynamic data for thousands of enzyme variants, in a small fraction of the time and at a minute fraction of the cost of traditional biochemical approaches. Our initial studies on an Alkaline Phosphatase superfamily member provide the first comprehensive functional landscape for an enzyme, delineating function throughout an enzyme scaffold. Studies on this and additional systems are needed to understand enzyme function, to reveal the action of drugs and allosteric effectors, and to develop rules to engineer new enzymes and pathways at will. Most generally, quantitative, high-throughput biochemical methodologies will usher in a post-genomic era in biology that is grounded in biochemical understanding and powered by quantitative physical models.





Daniel Herschlag (Stanford University)

]]>
Other Mon, 10 Dec 2018 18:15:21 -0500 2018-12-10T16:00:00-05:00 2018-12-10T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Chemistry Under Extreme Pressures (December 11, 2018 4:00pm) https://events.umich.edu/event/57212 57212-14130895@events.umich.edu Event Begins: Tuesday, December 11, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Pressure is a fundamental thermodynamic variable that spans roughly 50 orders of magnitude throughout the universe, yet practically all of our chemical intuition is based upon results obtained near atmospheric conditions. At pressures on the order of millions of atmospheres—the kind found deep within our planet—elemental properties that we consider fundamental become categorically altered. For example, atomic volumes drop sharply, valence orbital energies can fall below those of core orbitals, and electronegativities drift from their tabulated ambient pressure values. Even at relatively modest pressures of ~10,000–100,000 atm, which are now readily accessible in the laboratory, these effects can lead to surprising new chemical bonding, structures, and properties, opening up a new frontier for chemical exploration. In this talk, I will show how we have harnessed pressure to: (i) exert thermodynamic control to synthesize novel binary bismuth intermetallic compounds that are impossible to synthesize using traditional methods; and (ii) determine chemically-pure structure–function correlations in jarosite, a magnetically-frustrated mineral.




James Walsh, PhD (Northwestern University)

]]>
Other Tue, 11 Dec 2018 18:15:21 -0500 2018-12-11T16:00:00-05:00 2018-12-11T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: “Modern Approaches to the Development of Energetic Materials” (December 14, 2018 10:00am) https://events.umich.edu/event/58326 58326-14463230@events.umich.edu Event Begins: Friday, December 14, 2018 10:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Rosalyn V. Kent (Advisor: Prof. Adam Matzger)

]]>
Other Fri, 14 Dec 2018 18:15:20 -0500 2018-12-14T10:00:00-05:00 2018-12-14T11:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: “Computational Investigations of Organometallic Polymerization Reactions” (December 14, 2018 12:00pm) https://events.umich.edu/event/58325 58325-14463229@events.umich.edu Event Begins: Friday, December 14, 2018 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Andrew Vitek (Advisor: Prof. Paul Zimmerman)

]]>
Other Fri, 14 Dec 2018 18:15:20 -0500 2018-12-14T12:00:00-05:00 2018-12-14T13:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: “The decision landscapes in living cells” (December 14, 2018 4:00pm) https://events.umich.edu/event/53442 53442-13381411@events.umich.edu Event Begins: Friday, December 14, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: Live cells routinely make decisions that are informed by external stimuli and endogenous noisy regulatory networks. At this point, we lack a coherent understanding of how these decisions are made, although we have developed mechanistic descriptions of various instances of decision making processes in specific systems. In this talk, using the recent experimental and modeling analyses of cell migration, proliferation and death conducted at our lab, I will suggest a methodology for quantitative understanding of cellular decision making. I will also demonstrate that this method has a powerful predictive power, with particular applications to therapeutic interventions in cancer and other complex diseases. This approach can be extended to other systems and can lay the foundations for a more integrative analysis of cell function.

]]>
Workshop / Seminar Wed, 24 Oct 2018 14:21:39 -0400 2018-12-14T16:00:00-05:00 2018-12-14T17:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Andrew Levchenko
Thesis Defense: “Development of New Strategies Towards Accessing Chiral Nitrogen Heterocycles” (December 17, 2018 4:00pm) https://events.umich.edu/event/58327 58327-14463231@events.umich.edu Event Begins: Monday, December 17, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Emilia J. Groso (Advisor: Prof. Corinna Schindler)

]]>
Other Mon, 17 Dec 2018 18:15:25 -0500 2018-12-17T16:00:00-05:00 2018-12-17T17:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Molecular Mechanisms of Dynein Regulation by Lis1 (December 18, 2018 12:00pm) https://events.umich.edu/event/58362 58362-14485819@events.umich.edu Event Begins: Tuesday, December 18, 2018 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Faculty Candidate
Host: Anuj Kumar

]]>
Workshop / Seminar Tue, 11 Dec 2018 14:28:01 -0500 2018-12-18T12:00:00-05:00 2018-12-18T13:00:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar mcdb logo and microscope
Recent Advances in Biomacromolecular NMR and High-Speed-AFM (December 18, 2018 3:00pm) https://events.umich.edu/event/58311 58311-14461161@events.umich.edu Event Begins: Tuesday, December 18, 2018 3:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




David Weliky(Michigan State University) , Yusuke Nishiyama(JEOL RESONANCE & RIKEN, Japan) , Martine Monette(Bruker NMR, Canada) , Takahiro Watanabe-Nakayama(Kanazawa University, Japan) , Jeffrey Brender(NIH)

]]>
Other Tue, 18 Dec 2018 18:15:25 -0500 2018-12-18T15:00:00-05:00 2018-12-18T18:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
The effect of nucleosome conformation on histone tail binding: implications for chromatin signaling (December 18, 2018 4:00pm) https://events.umich.edu/event/55003 55003-13665197@events.umich.edu Event Begins: Tuesday, December 18, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Eukaryotic DNA exists in the cell nucleus via chromatin, which acts to both compact and regulate the genome. The basic subunit of chromatin is the nucleosome, which is comprised of a histone protein core, wrapped by ~147bp of DNA. The N-terminal regions of each of the histones protrude from the wrapped core and are referred to as the histone tails. Histone tails harbor a plethora of post-translational modifications (PTMs) that direct the function of chromatin regulators as they remodel chromatin during development and in response to external factors. Recognition of histone PTMs by these regulatory complexes is mediated through the action of reader sub-domains. The interaction of reader domains with modified histone tails has been extensively studied using peptide fragments of the tails. However, we have very little knowledge of how these domains associate with the full nucleosome. We are using NMR spectroscopy and complimentary orthogonal techniques to investigate this, and have found that the conformation of the histone tails in the context of the nucleosome has a dramatic effect on reader domain binding. As a model system, we are investigating the interaction of the BPTF PHD finger with its known cognate modification, methylated lysine 4 on histone H3 (H3K4me3). Here, we show that the conformation adopted by the histone H3 tails within the context of the nucleosome is inhibitory to binding of the BPTF PHD finger to H3K4me3, as compared to histone peptides. Using NMR spectroscopy and MD simulations, we find that the H3 tails interact robustly but dynamically with nucleosomal DNA, and demonstrate that this inhibits PHD finger association. Modifications and mutations of the H3 tail outside the binding region increase the accessibility to PHD finger binding, indicating that PTM crosstalk can regulate reader domain binding by altering the nucleosome conformation. Together, our results demonstrate that the nucleosome context has a dramatic impact on signaling events at the histone tails, and highlights the importance of studying histone binding in the context of the nucleosome.






Catherine Musselman (University of Iowa)

]]>
Other Tue, 18 Dec 2018 18:15:25 -0500 2018-12-18T16:00:00-05:00 2018-12-18T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Genomics-guided discovery of peptide natural products in microbes and plants (January 8, 2019 2:00pm) https://events.umich.edu/event/58825 58825-14563542@events.umich.edu Event Begins: Tuesday, January 8, 2019 2:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry










Roland Kersten, PhD (Massachusetts Institute of Technology)

]]>
Other Tue, 08 Jan 2019 18:15:29 -0500 2019-01-08T14:00:00-05:00 2019-01-08T15:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Dearomative Functionalization Strategies and Synthesis of Anticancer Natural Products (January 8, 2019 4:00pm) https://events.umich.edu/event/53788 53788-13461545@events.umich.edu Event Begins: Tuesday, January 8, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Small complex molecules are highly desired in all areas of chemistry, but they are also often difficult to access. Selective transformations of aromatic compounds could provide a more direct route to such desirable targets; however, the many challenges associated with dearomative functionalization have left these types of reactions widely underdeveloped. Our group has been developing new strategies that bridge the gap between dearomatization functionalization and alkene chemistry. In pursuit of this goal, we have developed dearomative functionalizations using small molecules – arenophiles – that enable reactions of isolated alkenes in aromatic substrates. Thus, well-established olefin reactions, such as dihydroxylation and reduction, can now be more directly applied to arenes. Additionally, arenophiles in combination with transition metal catalysis provide unique platform and enable the rapid access to a diverse range of products that are both challenging to synthesize via existing methods and complementary to those acquired through biological or chemical dearomative processes. Finally, using this methodology we have recently completed the synthesis of several complex anticancer natural products.










David Sarlah (University of Illinois)

]]>
Other Tue, 08 Jan 2019 18:15:28 -0500 2019-01-08T16:00:00-05:00 2019-01-08T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Charting "Unknown" Metabolism with Organelle Precision (January 10, 2019 11:45am) https://events.umich.edu/event/58364 58364-14485821@events.umich.edu Event Begins: Thursday, January 10, 2019 11:45am
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

MCDB Faculty Candidate
Host: JK Nandakumar

]]>
Workshop / Seminar Tue, 11 Dec 2018 14:31:14 -0500 2019-01-10T11:45:00-05:00 2019-01-10T12:45:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar mcdb logo and microscope
Seminar Title: "Predicting RNA Structure with Physics and Sequence Comparison" (January 11, 2019 4:00pm) https://events.umich.edu/event/53443 53443-13381412@events.umich.edu Event Begins: Friday, January 11, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: RNA structure is hierarchical. The primary structure is the sequence of nucleotides. The secondary structure is the set of canonical (AU, GC, and GU) base pairs. The tertiary structure is the three dimensional position of the atoms and the additional intramolecular contacts that mediate the fold.

The Mathews lab develops methods to predict both RNA secondary structure and tertiary structure. In this talk, I will introduce nearest neighbor parameters for estimating folding stability of secondary structures and dynamic programming algorithms that predict secondary structure. I will then talk about new work in our lab to compare sequences to model conserved secondary structures. We developed a new method, called TurboFold, which is able to rapidly refine predicted secondary structures using sequence comparison and rapidly refine sequence alignments using structure information. I will also talk about new work to model RNA folding stability using molecular mechanics and 3D models. We used umbrella sampling to estimate the unfolding free energy change differences for three stem-loop structures, and we found good agreement with experiments.

]]>
Workshop / Seminar Mon, 07 Jan 2019 16:52:23 -0500 2019-01-11T16:00:00-05:00 2019-01-11T17:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar David Mathews
Taking Inspiration From Bulk: Molecular Electrocatalysis and Magnetization Dynamics of Heterometallic Lanthanide – Transition Metal Complexes (January 16, 2019 4:00pm) https://events.umich.edu/event/52395 52395-12673362@events.umich.edu Event Begins: Wednesday, January 16, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The first part of the presentation will introduce our methodology towards improving molecular catalysts for energy relevant conversions. We strategically introduce redox-active and slightly acidic imidazolium moieties into the secondary coordination sphere of molecular CO2 reduction electrocatalysts. Results from systematic comparative studies will be presented that strongly suggest that mechanistic details of catalysis are altered for the new functionalized catalyst systems, resulting in improved catalytic metrics.

The second part of the seminar will discuss our strategies to study intramolecular interactions between transition metal (TM) and lanthanide (Ln) ions to generate novel spin systems that can display single-molecule magnet (SMM) properties. SMMs are very attractive candidates for the miniaturization of tunable information storage materials and quantum computing devices. Our work aims to generate heterometallic SMMs that feature either TM···Ln interactions or TM‑Ln bonding. I will present key results of our comprehensive structural and spectroscopic studies which have already led to the development of redox-switchable SMMs, new molecular platforms to facilitate strong magnetic coupling between Ln3+ ions, and hard SMM behavior."














Michael Nippe (Texas A&M University)

]]>
Other Wed, 16 Jan 2019 18:15:33 -0500 2019-01-16T16:00:00-05:00 2019-01-16T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
mitoCPR – A Stress Response that Maintains Mitochondria Homeostasis (January 17, 2019 11:45am) https://events.umich.edu/event/58365 58365-14485822@events.umich.edu Event Begins: Thursday, January 17, 2019 11:45am
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

MCDB Faculty Candidate
Host: Y Wang

]]>
Workshop / Seminar Tue, 11 Dec 2018 14:30:08 -0500 2019-01-17T11:45:00-05:00 2019-01-17T12:45:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar mcdb logo and microscope
Visualizing Ultrafast Electron Dynamics at Catalytic Surfaces. (January 17, 2019 4:00pm) https://events.umich.edu/event/52760 52760-13021396@events.umich.edu Event Begins: Thursday, January 17, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


Directly observing electron dynamics at surfaces is required to reveal the material properties that determine efficiency during energy conversion catalysis. Toward this goal, we have developed a tabletop instrument for femtosecond X-ray spectroscopy of surfaces. This method combines the benefits of X-ray absorption, such as element, oxidation, and spin state specificity, with surface sensitivity and ultrafast time resolution, having a probe depth of only a few nm and time resolution faster than 100 fs. Using this technique, we study the electron dynamics in a number of catalytically relevant metal oxides. Specifically, Fe2O3 is an earth-abundant semiconductor with a band gap ideally suited for solar light harvesting, but its catalytic performance is low due to surface electron trapping. In these studies, we show that surface trapping occurs in less than 1 ps. Surprisingly this process is not sensitive to Fe2O3 surface morphology, indicating that electron trapping is not influenced by surface defects. Instead, ultrafast trapping occurs by the interactions of the free electrons with the lattice nuclei via a process known as small polaron formation. In contrast to Fe2O3, CuFeO2 is a closely related earth-abundant photocatalyst, which can reduce CO2 using sunlight. Specifically, we have recently shown that CuFeO2 is a selective catalyst for photo-electrochemical CO2 reduction to acetate. However, the role of electronic structure and charge carrier dynamics in this process has not been well understood. Using ultrafast X-ray spectroscopy, it is possible to track electrons and holes independently in the Fe 3d, Cu 3d, and O 2p states comprising the band structure of this photocatalyst. Results show that photocatalytic activity is related to ultrafast hole relaxation leading to spatial charge separation in the layered CuFeO2 lattice, which cannot occur in Fe2O3. This ability to elucidate site-specific charge carrier dynamics in real time provides important criteria for the rational design of catalysts for efficient solar energy harvesting based on their underlying photophysics.







L. Robert Baker (Ohio State University)

]]>
Other Thu, 17 Jan 2019 18:15:30 -0500 2019-01-17T16:00:00-05:00 2019-01-17T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: "Architecture and Molecular Control of Cell-Cycle Entry and Exit Pathways: A Live-Cell Tale of Phosphorylation, Transcription and Degradation " (January 18, 2019 4:00pm) https://events.umich.edu/event/53444 53444-13381413@events.umich.edu Event Begins: Friday, January 18, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: Mammals must regulate the proliferation of stem, progenitor and differentiated cells to build, maintain, and repair tissues. Control of cell-cycle entry and exit has been conceptualized by the restriction point, a time when cells escape the need for mitogens to complete the cell cycle. Our single-cell microscopy studies discovered instead two parallel and partially redundant pathways to enter the cell cycle out of quiescence and three pathways out of mitosis. In lieu of a sharp restriction point, we find a progressive stabilization of both increasing CDK4/6 and CDK2 activities when tested by mitogen removal or stress, a stabilization that ends with an irreversible commitment point driven by multiple positive feedbacks. I will delineate core principles, molecular mechanisms and timing of this fundamental cell-fate commitment whose abnormal regulation is a main cause for cancer.

]]>
Workshop / Seminar Fri, 11 Jan 2019 14:00:58 -0500 2019-01-18T16:00:00-05:00 2019-01-18T17:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Tobias Meyer
Structural Insights into the 7SK Core RNP, a Major Regulator of Eukaryotic Transcription (January 22, 2019 11:45am) https://events.umich.edu/event/58366 58366-14485823@events.umich.edu Event Begins: Tuesday, January 22, 2019 11:45am
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

MCDB Faculty Candidate
Host: JK Nandakumar

]]>
Workshop / Seminar Mon, 17 Dec 2018 14:54:22 -0500 2019-01-22T11:45:00-05:00 2019-01-22T12:45:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar cartoon microscope on background of micro images
Next-generation tools for the synthesis of small molecules and biologics (January 22, 2019 4:00pm) https://events.umich.edu/event/52430 52430-12706750@events.umich.edu Event Begins: Tuesday, January 22, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry



The Walczak group studies methods to prepare and manipulate complex natural products and biologics such as (oligo)saccharides, peptides, and proteins. Our current interests are focused on the synthesis and chemical biology of mammalian and bacterial glycans that are known to engage in biological recognition and signaling events and show a promising therapeutic and diagnostic potential. While chemical synthesis has enabled a better understanding of the role of saccharides in homeostatic and developmental processes, key obstacles such as suboptimal selectivities in chemical glycosylation reactions await broadly applicable solutions. In this presentation, I will describe the development of metal-catalyzed methods that capitalize on stereoretentive reactions of anomeric nucleophiles suitable for the formation of C(sp3)-C and C(sp3)-heteroatom bonds. This seminar will also feature selected applications of the glycosyl cross-coupling method, mechanistic and computational studies that guided new reaction discovery, and integration with modern automation technologies.








Maciej Walczak (University of Colorado)

]]>
Other Tue, 22 Jan 2019 18:15:30 -0500 2019-01-22T16:00:00-05:00 2019-01-22T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Organizational Principles of 3D Genome Architecture (January 24, 2019 11:45am) https://events.umich.edu/event/58367 58367-14485824@events.umich.edu Event Begins: Thursday, January 24, 2019 11:45am
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

MCDB Faculty Candidate
Host: Laura Buttitta

]]>
Workshop / Seminar Tue, 11 Dec 2018 14:28:56 -0500 2019-01-24T11:45:00-05:00 2019-01-24T12:45:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar microscope image stained tissue
TBA (January 24, 2019 4:00pm) https://events.umich.edu/event/52431 52431-12706751@events.umich.edu Event Begins: Thursday, January 24, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Regan Thomson (Northwestern University)

]]>
Other Mon, 11 Jun 2018 12:15:23 -0400 2019-01-24T16:00:00-05:00 2019-01-24T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Staying one step ahead: fighting unfavorable kinetics in biomass conversion and catalysis (February 6, 2019 4:00pm) https://events.umich.edu/event/56197 56197-13862520@events.umich.edu Event Begins: Wednesday, February 6, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

After atmospheric CO2, lignocellulosic biomass is the second-largest source of renewable carbon on our planet. This makes biomass a very attractive source of sustainable alternatives to fossil-derived chemicals. The production of various chemicals from biomass usually involves the depolymerization of biomass’s three constituent polymers: cellulose and hemicellulose, which are both polysaccharides; and lignin, which is a polymer of phenyl propanoid sub-units. These three types of complex molecules are broken down into their constituent monomers, which include sugars and phenyl propane derivatives. In turn, these low-molecular weight monomers can be catalytically upgraded to either direct or indirect substitutes for petrochemicals. In both depolymerization and catalytic upgrading, the biggest challenge is usually not achieving the desired reaction, but rather avoiding being outcompeted by other, detrimental reactions. Depolymerization reactions of the major biomass constituents – polysaccharides and lignin – are often outpaced by subsequent degradation reactions of sugars and lignin intermediates. In parallel, coking reactions and catalyst deactivation processes plague the upgrading of highly oxygenated and water-miscible biomass derivatives.

In this talk, I will present several solutions to these challenges that my laboratory has developed. I will show how we can use protection group chemistry, both during lignin extraction and polysaccharide depolymerization, to reversibly “trap” stabilized intermediate molecules, and facilitate their high-yield upgrading1,2. Notably, we can show that, under the right conditions, extracted lignin can be catalytically upgraded at high yields to as few as 1-2 major products3. I will also discuss how targeted surface modifications on heterogeneous catalysts can lead to dramatic changes in activity, stability and selectivity, even in the presence of highly oxygenated renewable streams4–6.

References:
1 L. Shuai, M. T. Amiri, Y. M. Questell-Santiago, F. Héroguel, Y. Li, H. Kim, R. Meilan, C. Chapple, J. Ralph and J. S. Luterbacher*, Science, 2016, 354, 329–333.
2 Y. M. Questell-Santiago, R. Zambrano-Varela, M. T. Amiri and J. S. Luterbacher*, Nat. Chem., 2018, 1222–1228.
3 W. Lan, M. T. Amiri, C. M. Hunston and J. S. Luterbacher*, Angew. Chem. Int. Ed., 2018, 57, 1356–1360.
4 F. Héroguel, B. P. Le Monnier, K. S. Brown, J. C. Siu and J. S. Luterbacher*, Appl. Catal. B Environ., 2017, 218, 643–649.
5 F. Héroguel, L. Silvioli, Y.-P. Du and J. S. Luterbacher*, J. Catal., 2018, 358, 50–61.
6 J. H. Yeap, F. Héroguel, R. L. Shahab, B. Rozmysłowicz, M. H. Studer and J. S. Luterbacher*, ACS Catal., 2018, 8, 10769–10773.











Jeremy Luterbacher (École Polytechnique Fédérale de Lausanne)

]]>
Other Wed, 06 Feb 2019 18:15:58 -0500 2019-02-06T16:00:00-05:00 2019-02-06T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
What makes a C student a C student? (February 8, 2019 12:00pm) https://events.umich.edu/event/54390 54390-13576740@events.umich.edu Event Begins: Friday, February 8, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Diane Bunce

]]>
Other Fri, 08 Feb 2019 18:15:52 -0500 2019-02-08T12:00:00-05:00 2019-02-08T14:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: Emergent properties of membrane proximal signaling events (February 8, 2019 4:00pm) https://events.umich.edu/event/53445 53445-13383532@events.umich.edu Event Begins: Friday, February 8, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: In eukaryotes, cell polarity emerges from the complex interplay between plasma membrane and cytoplasmic molecules, most notably phosphatidylinositol phosphate (PIP) lipids, lipid modifying enzymes, small GTPases, and the actin cytoskeleton. In many cases, competition between lipid kinases and phosphatases underlies the production of PIP lipids that become asymmetrically distributed across the plasma membrane. Although many of the enzymes that regulate PIP lipid synthesis in vivo have been identified, questions concerning how PIP lipid phosphorylation reactions are rapidly turned ON and OFF remain unanswered. The Hansen lab has taken a reductionist approach to biochemically reconstitute minimal sets of signaling molecules that control PIP lipid phosphorylation at the plasma membrane. The knowledge gained from our biochemical analysis has provided new insights concerning how lipid modifying enzymes regulate the formation of transient, polarized, and oscillatory PIP lipid signaling reactions in living cells.

]]>
Workshop / Seminar Wed, 02 Jan 2019 16:52:31 -0500 2019-02-08T16:00:00-05:00 2019-02-08T17:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Scott Hanson
Job Search Advice from ECRC Peer Advisors for ChE Students (February 11, 2019 1:30pm) https://events.umich.edu/event/60749 60749-14961650@events.umich.edu Event Begins: Monday, February 11, 2019 1:30pm
Location: Chemistry Dow Lab
Organized By: Engineering Career Resource Center

ChE Students: Navigating the job search process can be difficult, especially after the engineering career fair when you are left asking the question: What happens next? The ECRC student peer advisors have been there many times, and they are coming to your department to help you with your next steps! Come by between classes and chat with a peer advisor to ask any questions you may have with the concluding of the career fair and to learn more about the many services the ECRC offers to help students succeed in their unique job search.

]]>
Careers / Jobs Mon, 04 Feb 2019 10:52:59 -0500 2019-02-11T13:30:00-05:00 2019-02-11T15:00:00-05:00 Chemistry Dow Lab Engineering Career Resource Center Careers / Jobs Chemistry Dow Lab
P-Chem Student Seminars (February 14, 2019 4:00pm) https://events.umich.edu/event/59056 59056-14677931@events.umich.edu Event Begins: Thursday, February 14, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Yifan Lai, Kevin Skinner

]]>
Other Thu, 14 Feb 2019 18:15:54 -0500 2019-02-14T16:00:00-05:00 2019-02-14T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: TBA (February 15, 2019 4:00pm) https://events.umich.edu/event/53446 53446-13383533@events.umich.edu Event Begins: Friday, February 15, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: TBA

]]>
Workshop / Seminar Wed, 03 Oct 2018 13:51:20 -0400 2019-02-15T16:00:00-05:00 2019-02-15T17:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Dolnald Hamelberg
Nitrogen Binding and Fixation using Iron Complexes (February 19, 2019 4:00pm) https://events.umich.edu/event/55303 55303-13716036@events.umich.edu Event Begins: Tuesday, February 19, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Nitrogen reduction (or "fixation") has been a longstanding target of study in chemistry because of the compelling goal of utilizing abundant, cheap atmospheric nitrogen for chemical synthesis. Current methods reduce nitrogen to ammonia at high temperatures and pressures. This seminar will discuss our research into low-temperature nitrogen fixation, as well as new mechanisms that lead to organic products from nitrogen. One of our strategies borrows from the natural enzyme, nitrogenase, which uses an unusual iron-sulfur cluster whose atomic-level mechanism is mysterious. This motivates the development of iron-sulfur complexes with unusual shapes, and study of their interactions with nitrogen and other nitrogenase substrates. Another strategy involves low-coordinate iron coordination compounds, which display new mechanisms for breaking the N-N bond of nitrogen. Studies on low-valent iron compounds have led to the first example of converting nitrogen and arenes directly into aniline products.




Pat Holland (Yale University)

]]>
Other Tue, 19 Feb 2019 18:15:48 -0500 2019-02-19T16:00:00-05:00 2019-02-19T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Panoptic Mass Spectrometry: How and Why? (February 21, 2019 4:00pm) https://events.umich.edu/event/59307 59307-14730588@events.umich.edu Event Begins: Thursday, February 21, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The complexity of contemporary research requires interdisciplinary efforts, and mass spectrometry (MS) is poised to play an important role. The presentation is intended to demonstrate two recent MS experiments designed to facilitate (1) the detection of every ionic species originating from the ion source and (2) an on-demand diagnostic strategy for the under-served population.









Abraham Badu-Tawiah (Ohio State University)

]]>
Other Thu, 21 Feb 2019 18:15:52 -0500 2019-02-21T16:00:00-05:00 2019-02-21T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: TBA (February 22, 2019 4:00pm) https://events.umich.edu/event/53447 53447-13383534@events.umich.edu Event Begins: Friday, February 22, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: TBA

]]>
Workshop / Seminar Wed, 03 Oct 2018 13:52:23 -0400 2019-02-22T16:00:00-05:00 2019-02-22T17:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Zhend Jie
New Frontiers in Catalytic Heteroatom Transfer: (February 26, 2019 4:00pm) https://events.umich.edu/event/52437 52437-12717006@events.umich.edu Event Begins: Tuesday, February 26, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


Heteroatom transfer reactions – frequently used by Nature for both the biosynthesis of natural products and the metabolism of xenobiotics – are fundamentally useful for the synthesis of pharmaceuticals and other bioactive compounds. As an example of one application, the site-selective oxidation of carbon-hydrogen bonds can be a powerful tool, especially when applied to late-stage functionalization. Transition metal catalysis of site-selective C–H oxidation has rapidly advanced in recent years, but there are nevertheless substantial challenges that remain with regards to achieving catalyst-controlled selectivity. Research in the Hilinski lab has focused on advancing organocatalysis as an alternative approach to transition metal catalysis of C–H functionalization, in order to exploit its potential advantages and complementarity. In this presentation, multiple approaches to organocatalytic C–H oxidation that have resulted in methods for C–H hydroxylation and the first organocatalytic method for C–H amination will be presented, with a focus on catalyst design, selectivity in complex settings, and mechanism. More recently, the lab’s focus on applications of catalytic heteroatom transfer has broadened to include other late-stage oxidations relevant to drug discovery (e.g. metabolic N-oxidation) and the discovery of novel cycloaddition reactions initiated by heteroatom transfer. Recent results in these areas will therefore also be presented, with a focus on applications relevant to bioactive small molecule synthesis.







Michael Hilinski (University of Virgina)

]]>
Other Tue, 26 Feb 2019 18:15:30 -0500 2019-02-26T16:00:00-05:00 2019-02-26T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Reactions Can Change the World (February 27, 2019 9:00am) https://events.umich.edu/event/61404 61404-15099303@events.umich.edu Event Begins: Wednesday, February 27, 2019 9:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




LC Campeau (Merck)

]]>
Other Wed, 27 Feb 2019 18:15:38 -0500 2019-02-27T09:00:00-05:00 2019-02-27T10:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Toward Exact Quantum Chemistry by a Combination of Stochastic Wave Function Sampling and Deterministic Coupled-Cluster Computations (February 28, 2019 4:00pm) https://events.umich.edu/event/59308 59308-14730589@events.umich.edu Event Begins: Thursday, February 28, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

One of the main goals of electronic structure theory is precise ab initio description of increasingly complex polyatomic systems. It is widely accepted that size extensive methods based on the coupled-cluster (CC) theory are excellent candidates for addressing this goal. Indeed, when applied to molecular properties and chemical reaction pathways, the CC hierarchy, including CCSD, CCSDT, CCSDTQ, etc., rapidly converges to the limit of the exact, full configuration interaction (FCI), diagonalization of the Hamiltonian, allowing one to capture the relevant many-electron correlation effects in a conceptually straightforward manner through particle-hole excitations from a single Slater determinant. One of the key challenges has been how to incorporate higher-than-two-body components of the cluster operator, needed to achieve a quantitative description, without running into prohibitive computational costs of CCSDT, CCSDTQ, and similar schemes, while eliminating failures of the more practical perturbative approximations of the CCSD(T) type in multi-reference situations, such as chemical bond breaking. In this talk, we examine a radically new way of obtaining accurate energetics equivalent to high-level CC calculations, even when electronic quasi-degeneracies become significant, at the small fraction of the computational cost, while preserving the black-box character of single-reference computations. The key idea is a merger of the deterministic formalism, abbreviated as CC(P;Q) [1,2], with the stochastic CI [3,4] and CC [5] Quantum Monte Carlo (QMC) approaches [6]. We also demonstrate that one can take the merger of the stochastic and deterministic ideas to the ultimate level and use it to enable precise extrapolations of the exact, FCI, energetics based on the early stages of FCIQMC propagations [7]. The advantages of the new methodologies will be illustrated by molecular examples, where the goal is to recover the nearly exact, CCSDT and CCSDTQ, and exact, FCI, energetics in situations involving chemical bond dissociations and reaction pathways. Possible extensions of this work to excited electronic states [8] and strongly correlated systems [9] will be mentioned as well.

[1] J. Shen and P. Piecuch, Chem. Phys. 401, 180 (2012); J. Chem. Phys. 136, 144104 (2012); J. Chem. Theory Comput. 8, 4968 (2012).
[2] N. P. Bauman, J. Shen, and P. Piecuch, Mol. Phys. 115, 2860 (2017).
[3] G. H. Booth, A. J. W. Thom, and A. Alavi, J. Chem. Phys. 131, 054106 (2009).
[4] D. Cleland, G. H. Booth, and A. Alavi, J. Chem. Phys. 132, 041103 (2010).
[5] A. J. W. Thom, Phys. Rev. Lett. 105, 263004 (2010).
[6] J. E. Deustua, J. Shen, and P. Piecuch, Phys. Rev. Lett. 119, 223003 (2017); in preparation for J. Chem. Phys.
[7] J. E. Deustua, I. Magoulas, J. Shen, and P. Piecuch, J. Chem. Phys. 149, 151101 (2018).
[8] J. E. Deustua, S. H. Yuwono, J. Shen, and P. Piecuch, to be submitted to J. Chem. Phys.
[9] J. E. Deustua, I. Magoulas, J. Shen, and P. Piecuch, in preparation for Phys. Rev. Lett.



Piotr Piecuch (Michigan State University)

]]>
Other Thu, 28 Feb 2019 18:15:31 -0500 2019-02-28T16:00:00-05:00 2019-02-28T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Sustainable Nation: Urban Design Patterns for the Future (February 28, 2019 6:00pm) https://events.umich.edu/event/61111 61111-15036260@events.umich.edu Event Begins: Thursday, February 28, 2019 6:00pm
Location: Chemistry Dow Lab
Organized By: Program in the Environment (PitE)

“If you think our country is on the wrong course environmentally, then this talk and book are for you.”

Our society should be able to rally to face urgent challenges like global warming, but we are not. In his new book Sustainable Nation: Urban Design Patterns for the Future (Wiley 2018) Doug Farr argues persuasively that we have been going about it all wrong, proposes a reset, and a clear path forward. This inspirational and sobering talk will forever change your understanding of the challenges we face, the urgency with which we need to face them, and your leading role in our generation’s call to act.

]]>
Lecture / Discussion Wed, 20 Feb 2019 10:54:04 -0500 2019-02-28T18:00:00-05:00 2019-02-28T19:30:00-05:00 Chemistry Dow Lab Program in the Environment (PitE) Lecture / Discussion Chemistry Dow Lab
Deciphering patterns in selective small molecule:RNA interactions (March 5, 2019 4:00pm) https://events.umich.edu/event/59464 59464-14745531@events.umich.edu Event Begins: Tuesday, March 5, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

While small molecules offer a unique opportunity to target structural and regulatory elements in therapeutically relevant RNAs, selectivity has been a recurrent challenge in small molecule:RNA recognition. In particular, RNAs tend to be more dynamic and offer less chemical functionality than proteins, and biologically active ligands must compete with the highly abundant and highly structured RNA of the ribosome. Indeed, no small molecule drugs targeting RNAs other than the ribosome are currently available, and our recent survey of the literature revealed little more than one hundred reported chemical probes that target non-ribosomal RNA in biological systems. As part of our efforts to improve small molecule targeting strategies and gain fundamental insights into small molecule:RNA recognition, we are analyzing patterns in both RNA-biased small molecule chemical space and RNA topological space privileged for differentiation. To begin, we identified physicochemical, structural, and spatial properties of biologically active RNA ligands that are distinct from those of protein-targeted ligands. Elaboration of four RNA binding scaffolds into a library enriched with these properties has led to improved recognition of medicinally relevant RNA targets, including viral and long noncoding RNA structures. At the same time, we used pattern recognition protocols to identify RNA topologies that can be differentially recognized by small molecules and have elaborated this technique to visualize conformational changes in RNA secondary structure. We are currently expanding these studies with the ultimate goal of applying these insights to the rapid development of ligands with high affinity and specificity for a wide range of RNA targets, particularly those critical to cancer progression.













Amanda Hargrove (Duke University)

]]>
Other Tue, 05 Mar 2019 18:15:30 -0500 2019-03-05T16:00:00-05:00 2019-03-05T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Coordination chemistry approaches for developing 19F magnetic resonance biosensors (March 6, 2019 4:00pm) https://events.umich.edu/event/53805 53805-13463692@events.umich.edu Event Begins: Wednesday, March 6, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

19F Magnetic resonance imaging (MRI) is an emerging technique for in vivo imaging, showing great promise due to the favorable NMR properties of the fluorine nucleus (high sensitivity, large ppm range) and the lack of detectable fluorine signal in biological systems. Imaging agents can be designed that exhibit either a turn-on or chemical shift response that is selective for a specific biological molecule or event. We are developing a series of metal complexes designed to report on different biological environments associated reductive stress (hypoxia), oxidative stress, changes in pH, metal ion concentration, and enzymatic activity. These sensors act via a switch from a paramagnetic to diamagnetic state upon reduction or oxidation at the metal center. Through careful tuning of the ligand scaffold, we have developed selective sensors for hypoxia and oxidative stress, showing promise for future applications for in vivo detection of these states in both cellular and animal disease models. New enhanced nanoparticle-based platforms based on metal-doped perfluorocarbons will also be discussed.
















Emily Que (The University of Texas at Austin)

]]>
Other Wed, 06 Mar 2019 18:15:31 -0500 2019-03-06T16:00:00-05:00 2019-03-06T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Biosciences Initiative RNA Faculty Candidate Seminar (March 7, 2019 4:00pm) https://events.umich.edu/event/61952 61952-15241362@events.umich.edu Event Begins: Thursday, March 7, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Center for RNA Biomedicine

“Spatiotemporal regulation of mRNA function in health and neurological disease”

]]>
Lecture / Discussion Thu, 07 Mar 2019 15:04:44 -0500 2019-03-07T16:00:00-05:00 2019-03-07T17:00:00-05:00 Chemistry Dow Lab Center for RNA Biomedicine Lecture / Discussion flyer
High-Precision Analyses of True Single-Molecule Chemistry using Nanopore Methods (March 7, 2019 4:00pm) https://events.umich.edu/event/61219 61219-15054302@events.umich.edu Event Begins: Thursday, March 7, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Measurement of single-molecule reactions can elucidate microscopic mechanisms that are often hidden from ensemble analysis. This presentation report the acid-base titration of a single DNA duplex confined within the wild-type ?-hemolysin (?-HL) nanopore for up to 3 hours. Analysis of the pH-dependent kinetics of >100,000 base flipping events of a single GC base pair using a hidden Markov kinetic model demonstrates that protonation/deprotonation occurs while the base pair is in the intra-helical state. Our experiments correspond to the longest single-molecule chemical reaction kinetic measurements performed using a nanopore.
















Henry White (University of Utah)

]]>
Other Thu, 07 Mar 2019 18:15:30 -0500 2019-03-07T16:00:00-05:00 2019-03-07T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: "Improving Traveling Wave Ion Mobility Mass Spectrometry for Proteomics" (March 11, 2019 10:00am) https://events.umich.edu/event/60561 60561-14910375@events.umich.edu Event Begins: Monday, March 11, 2019 10:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Sarah Haynes (Advisor: Prof. Brent Martin)

]]>
Other Mon, 11 Mar 2019 18:15:32 -0400 2019-03-11T10:00:00-04:00 2019-03-11T11:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Surfing the excited state energy surface towards new applications in photochemistry and biomedicine (March 12, 2019 12:00pm) https://events.umich.edu/event/57634 57634-14246148@events.umich.edu Event Begins: Tuesday, March 12, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

We present recent work on the study and application of environmentally sensitive excited states. Our central hypothesis is that environmentally sensitive deactivation of the molecular excited state can be used to selectively turn a photo-deprotection reaction ON and OFF. Because photochemistry is a zero-sum competition of the rates of different excited state processes, the manipulation of those rates by the environment selects which pathway is dominant. We discuss applications in material synthesis, biomedical diagnostics and peptide chemistry.













Brett VanVeller (Iowa State University)

]]>
Other Tue, 12 Mar 2019 18:15:32 -0400 2019-03-12T12:00:00-04:00 2019-03-12T13:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: "Symmetry-based Design of Protein Nano-cages" (March 12, 2019 2:00pm) https://events.umich.edu/event/61814 61814-15190876@events.umich.edu Event Begins: Tuesday, March 12, 2019 2:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Ajitha S. Cristie-David (Advisor: Prof. Neil Marsh)

]]>
Other Tue, 12 Mar 2019 18:15:32 -0400 2019-03-12T14:00:00-04:00 2019-03-12T15:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Biosciences Initiative RNA Faculty Candidate Seminar (March 13, 2019 4:00pm) https://events.umich.edu/event/61951 61951-15241354@events.umich.edu Event Begins: Wednesday, March 13, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Center for RNA Biomedicine

“Uncovering post-transcriptional regulatory mechanisms underlying human diseases Through CRISPR-based screening strategies”

]]>
Lecture / Discussion Thu, 07 Mar 2019 14:58:32 -0500 2019-03-13T16:00:00-04:00 2019-03-13T17:00:00-04:00 Chemistry Dow Lab Center for RNA Biomedicine Lecture / Discussion flyer
P-Chem Student Seminars (March 14, 2019 4:00pm) https://events.umich.edu/event/59057 59057-14677932@events.umich.edu Event Begins: Thursday, March 14, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Alan Rask, Audrey Eshun

]]>
Other Thu, 14 Mar 2019 18:15:51 -0400 2019-03-14T16:00:00-04:00 2019-03-14T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
CSIE|UM: Getting Started Today: Creative Strategies to Establish & Fund Excellent Undergraduate Research at Small Universities (March 15, 2019 12:00pm) https://events.umich.edu/event/61164 61164-15045283@events.umich.edu Event Begins: Friday, March 15, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


Establishing a successful undergraduate research program can be challenging, particularly at a small college or university where most faculty are not involved in research and startup packages are not offered. Jeff has been able to develop creative, collaborative, self-funding strategies which have allowed him to set up research programs for his undergraduate students in industry (AbbVie, Lilly), academia (Duquesne, Harvard), government (NIH), and others (DNDi). In this discussion he will share tips and challenges and explain how the reputation, relationships, and research you are establishing today in graduate school or in your postdoc can provide numerous opportunities for launching and sustaining an excellent undergraduate research program or business in the future.






Jeffrey Rohde (Franciscan University of Steubenville)

]]>
Other Fri, 15 Mar 2019 18:15:48 -0400 2019-03-15T12:00:00-04:00 2019-03-15T13:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Studies of RNA methylation and chromatin architecture (March 18, 2019 4:00pm) https://events.umich.edu/event/53789 53789-13461546@events.umich.edu Event Begins: Monday, March 18, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Over 150 types of post-transcriptional RNA modifications have been identified in all kingdoms of life. We have discovered the first two RNA demethylases, FTO and ALKBH5, which catalyze oxidative demethylation of the most prevalent modifications of mammalian messenger RNA (mRNA) and other nuclear RNA, N6-methyladenosine (m6A). These findings indicate that reversible RNA modification could impact biological regulation analogous to the well-known reversible DNA and histone chemical modifications. We have also characterized proteins that selectively recognize m6A-modified mRNA and affect the translation status and lifetime of the target mRNA, as well as molecular machines that deposit the m6A methylation on mRNA. Functional studies reveal m6A methylation as a critical mechanism to synchronize groups of transcripts for coordinated metabolism, translation, and decay, allowing timely and coordinated protein synthesis and transcriptome switching during cell differentiation and development. Misregulations of these processes lead to embryo lethality and human diseases such as cancer. I will also present recent studies on developing chemical platforms for proximity capture in probing DNA-DNA proximity.






Chuan He (University of Chicago)

]]>
Other Mon, 18 Mar 2019 18:15:41 -0400 2019-03-18T16:00:00-04:00 2019-03-18T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Alcohol and Amine Derivatives Guide Position-Selective C–H Functionalization Reactions (March 19, 2019 4:00pm) https://events.umich.edu/event/51507 51507-12126782@events.umich.edu Event Begins: Tuesday, March 19, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Free radical reactions represent an important and versatile class of chemical transformations. Nitrogen-centered radical applications remain underexplored due to the lack of convenient methods for their generation. Recent advances have improved access to nitrogen-centered radicals through photoredox-mediated oxidation of two such directing groups: amides and sulfonamides. Guided by this approach, we hypothesized that alcohols, masked as sulfamate esters, and amines, masked as sulfamides, could engage in photoredox-mediated oxidation to furnish nitrogen-centered radicals that could guide C–H functionalization reactions.
Moreover, our directed technology has been inspired by one of the most reliable and powerful known reactions to guide C–H functionalization reactions: the Hofmann–Löffler–Freytag (HLF) reaction, which uses amines or amides as directing groups. Like many of the most robust radical-mediated technologies to direct the activation of tertiary and secondary centers, the HLF reaction is guided through 1,5-hydrogen-atom transfer (HAT) processes, which proceeds through a kinetically-favorable six-membered ring transition state. By contrast, few reports describe 1,6-HAT with a traceless linker, such as an alcohol masked as a sulfamate ester or an amine masked as a sulfamide, and there are no general strategies to enable masked alcohols or amines to direct functionalization of aliphatic ?-C(sp3)–H centers. This talk will outline this novel strategy to harness alcohols and amines to replace C–H bonds at ?-C(sp3)–H centers, which are not generally accessible to directed functionalization. We will demonstrate that C–H abstraction can be robustly coupled with varied functionalization reactions. This talk will highlight one of the first generalizable synthetic strategies to functionalize ?-C(sp3)–H bonds based on masked alcohols or amines, to push the boundaries of organic chemistry at a fundamental level and benefits drug discovery.











Jennifer Roizen (Duke University)

]]>
Other Tue, 19 Mar 2019 18:15:46 -0400 2019-03-19T16:00:00-04:00 2019-03-19T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Annual Symposium in Biophysics (March 20, 2019 8:00am) https://events.umich.edu/event/62367 62367-15355274@events.umich.edu Event Begins: Wednesday, March 20, 2019 8:00am
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

This year’s symposium features a Biophysics Showcase which will include speakers from biophysics core labs, a themed session entitled “Advances in Protein Design” and a poster session with poster awards. Faculty, post-docs, grad students and undergrads are all welcome to participate.

Registration opens March 27th, 2019: http://sites.lsa.umich.edu/biophysics-symposium/

]]>
Conference / Symposium Wed, 20 Mar 2019 15:13:43 -0400 2019-03-20T08:00:00-04:00 2019-03-20T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Conference / Symposium Chemistry Dow Lab
P-Chem Student Seminars (March 21, 2019 4:00pm) https://events.umich.edu/event/59058 59058-14677933@events.umich.edu Event Begins: Thursday, March 21, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Yanbing Zhou, Joseph Meadows

]]>
Other Thu, 21 Mar 2019 18:15:44 -0400 2019-03-21T16:00:00-04:00 2019-03-21T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: TBA (March 22, 2019 4:00pm) https://events.umich.edu/event/53448 53448-13383535@events.umich.edu Event Begins: Friday, March 22, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: TBA

]]>
Workshop / Seminar Mon, 06 Aug 2018 15:06:40 -0400 2019-03-22T16:00:00-04:00 2019-03-22T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Sarah Woodson
If you are going to make a fuel from sunlight, water, and air, what should it be? (March 25, 2019 4:00pm) https://events.umich.edu/event/52155 52155-12488633@events.umich.edu Event Begins: Monday, March 25, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Electrocatalysts for the reduction of CO2 are of interest in the production of solar fuels, and as a means of mitigating atmospheric CO2. The question of which solar fuels should be made from CO2 is an important one. Unlike water splitting (H2O ? H2 + ½ O2) where a single reduced product (H2) is obtained, the reduction of CO2 can produce a variety of different chemical reduction products, CO, HCOOH, H2CO, CH3OH, CH4, to name a few, as well as C2 and higher products. Which product(s) will be produced from solar energy, and then be used as building blocks to manufacture higher fuels and specialty chemicals is not presently known. Indeed, the question of whether CO2 should be reduced electrochemically to an organic molecule, or instead, hydrogen produced by water splitting, should be used to hydrogenate CO2 to organic products is not clearly understood at this time. There are very few known catalysts for the efficient hydrogenation of CO2, so whether electrochemical reduction or hydrogenation of CO2 is ultimately practiced on an industrial scale, the development of new catalysts will be required to enable new technology. Results from several recent approaches to producing higher value solar fuels from CO2 including synthetic biology and tandem catalysis are presently under investigation. Several recent accomplishments in the activation and electrochemical reduction of CO2 have been achieved. These include the use of earth-abundant metals including manganese, in place of rhenium and ruthenium, and the use of artificial co-factors to promote catalysis. Other recent approaches to developing catalysts for the reduction of CO2 include the deployment of proton relays in associated ligands to manage proton transport, introduction of new systems in which proton coupled electron transfer for efficient H-atom transfers can be effected, supramolecular catalyst assemblies that use non-covalent interactions to direct catalyst centers toward substrate activation, and artificial metalloprotein electrocatalysts. The general properties of molecular catalysts on conducting substrates under bias as probed by surface spectroscopies pose challenges to researchers attempting to do catalysis at an electrified interface. Surface spectroscopies can provide detailed information about the electronic structure and environmental effects of catalysts operating within the diffusion layer of an electrode under bias.










Cliff Kubiak (University of California San Diego)

]]>
Other Mon, 25 Mar 2019 18:15:38 -0400 2019-03-25T16:00:00-04:00 2019-03-25T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Enantioselective Chemical Synthesis Methods via Cooperative Catalysis: Design, Development and Application (March 26, 2019 4:00pm) https://events.umich.edu/event/57287 57287-14148782@events.umich.edu Event Begins: Tuesday, March 26, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our laboratory has embraced cooperative catalysis as a general framework for the design of new enantioselective reactions. Within this regime we have exploited cooperation between Lewis base and transition metal catalysts as an effective means to control and direct both reaction partners during bond construction. The versatility of this approach is such that each catalyst acts in an orthogonal manner, which permits the role and function of the metal center to be modified and tuned without compromising enantioselectivity. This seminar will describe our most recent efforts in asymmetric carbon–carbon and carbon-nitrogen bond formation.












Thomas Snaddon (Indiana University)

]]>
Other Tue, 26 Mar 2019 18:15:39 -0400 2019-03-26T16:00:00-04:00 2019-03-26T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: "Protein-Protein Interaction Analysis: Expanded Hydrogen/Deuterium Exchange Tandem Mass Spectrometry and Host Cell Protein Characterization" (March 27, 2019 2:00pm) https://events.umich.edu/event/62060 62060-15284703@events.umich.edu Event Begins: Wednesday, March 27, 2019 2:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Qingyi Wang (Thesis Advisor: Prof. Kicki Hakansson)

]]>
Other Wed, 27 Mar 2019 18:15:42 -0400 2019-03-27T14:00:00-04:00 2019-03-27T15:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: "Enhanced, Live-Cell, Super-Resolution Imaging and Single-Molecule Emission Spectrum Reshaping” (March 28, 2019 1:00pm) https://events.umich.edu/event/62061 62061-15284704@events.umich.edu Event Begins: Thursday, March 28, 2019 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Stephen Lee (Thesis Advisor: Prof. Julie Biteen)

]]>
Other Thu, 28 Mar 2019 18:15:45 -0400 2019-03-28T13:00:00-04:00 2019-03-28T14:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: "Enhanced, Live-Cell, Super-Resolution Imaging and Single-Molecule Emission Spectrum Reshaping" (March 28, 2019 1:00pm) https://events.umich.edu/event/60562 60562-14910376@events.umich.edu Event Begins: Thursday, March 28, 2019 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Stephen Lee (Advisor: Julie Biteen)

]]>
Other Thu, 28 Mar 2019 18:15:45 -0400 2019-03-28T13:00:00-04:00 2019-03-28T14:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Ultrafast Nonlinear IR Spectroscopy for Exotic Molecular Materials (March 28, 2019 4:00pm) https://events.umich.edu/event/57406 57406-14186925@events.umich.edu Event Begins: Thursday, March 28, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


In this seminar, I will discuss two developments of ultrafast nonlinear IR spectroscopy for exotic molecular materials: (1) 2D IR spectroscopy for molecular vibrational polaritons and (2) heterogeneous water dynamics templated by self-assembled materials. Both show the advantages of ultrafast nonlinear IR spectroscopic technique to decipher hidden physics of exotic molecular materials.
2D IR of Molecular Polaritons. Molecular vibrational polaritons, hybrid half-light, half-matter quasiparticles, are studied using ultrafast coherent 2D IR spectroscopy. Molecular vibrational-polaritons are anticipated to open opportunities for new photonic and molecular phenomena. Many of these developments hinge on fundamental understanding of physical properties of molecular vibrational polaritons. Using 2D IR spectroscopy to study vibrational-polaritons, we obtained results that challenge and advance both polariton and spectroscopy fields, which invokes new development of theory for the spectroscopy, observation of new nonlinear optical effects and unexpected responses from hidden dark states These results will have significant implications in novel infrared photonic devices, lasing, molecular quantum simulation, as well as new chemistry by tailoring potential energy landscapes.
Heterogeneous water dynamics templated by self-assembled materials. We report observations of mesoscopically homogeneous but macroscopically heterogenous water dynamics in self-assembled materials by a new, spatially resolved infrared (IR) pump vibrational sum frequency generation (VSFG) probe microscope. We found that the strong hydrogen-bond interactions between host molecules and nearby water not only template nearby water networks to adopt the chirality of self-assembled materials, but also induce resonant energy transfer from ?-CD to nearby water, which is heterogeneous among domains, but uniform within domains.






Wei Xiong (UC-San Diego)

]]>
Other Thu, 28 Mar 2019 18:15:44 -0400 2019-03-28T16:00:00-04:00 2019-03-28T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
�Evolution of Blood Gas Testing for Critical Care� (March 29, 2019 12:00pm) https://events.umich.edu/event/61802 61802-15188646@events.umich.edu Event Begins: Friday, March 29, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Sohrab Mansouri (Instrumentation Laboratory, Inc)

]]>
Other Fri, 29 Mar 2019 18:15:39 -0400 2019-03-29T12:00:00-04:00 2019-03-29T13:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: Elevators in cell membrane: structure and dynamics of nutrient transporters (March 29, 2019 4:00pm) https://events.umich.edu/event/53450 53450-13383537@events.umich.edu Event Begins: Friday, March 29, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

ABSTRACT: TBA

]]>
Workshop / Seminar Mon, 25 Mar 2019 09:20:49 -0400 2019-03-29T16:00:00-04:00 2019-03-29T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Ming Zou
Seminar Title: “Protein conformational change we can believe in!” (April 5, 2019 4:00pm) https://events.umich.edu/event/53451 53451-13383538@events.umich.edu Event Begins: Friday, April 5, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

ABSTRACT: Protein conformational landscapes are complex and predicting the conformational response to physiologically relevant perturbations like mutation or small molecule binding is a major challenge. Often, functionally-relevant states are nearly isoenergetic (separated in energy by a few kT, or less), meaning that at physiological temperatures, multiple conformational states populate the ensemble. Using newly developed multiconformer models of X-ray crystallography data, we have shown how population shifts can result from simple temperature perturbation. Our experience over multiple systems has demonstrated that temperature sensitive conformational states are the same ones used by evolution to create new functions, by small molecules in creating new binding sites, and by enzymes to transit through a catalytic cycle. Using an easily controllable physical perturbation (temperature) to predict the conformational response to physiological perturbations suggests the specific conformations to enforce at allosteric sites to achieve long-range control over protein activity.

]]>
Workshop / Seminar Wed, 03 Apr 2019 15:41:52 -0400 2019-04-05T16:00:00-04:00 2019-04-05T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar James Fraser
TBA (April 9, 2019 4:00pm) https://events.umich.edu/event/62107 62107-15293418@events.umich.edu Event Begins: Tuesday, April 9, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




David Needham (Duke University)

]]>
Other Thu, 14 Mar 2019 06:15:38 -0400 2019-04-09T16:00:00-04:00 2019-04-09T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
EEB Special Seminar: Butterfly spots and rattlesnake tales: the evolution of novelty (April 10, 2019 12:00pm) https://events.umich.edu/event/49670 49670-11487555@events.umich.edu Event Begins: Wednesday, April 10, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Ecology and Evolutionary Biology

The origin of novelty is one of the central questions of evolution. My laboratory has been focused on the genetic mechanisms underlying the evolution of animal form, and more recently, on biochemical novelties such as the evolution of snake venom. While the general mechanisms involved are distinct, the one common lesson these two pursuits have provided is, in biology, to expect the unexpected.

Short bio
Sean B. Carroll is an award-winning scientist, writer, educator and film producer.
He is Vice President for Science Education of the Howard Hughes Medical Institute, the largest private supporter of science education activities in the U.S., and Professor of Biology at the University of Maryland.

Sean’s laboratory research has centered on the genes that control animal body patterns and play major roles in the evolution of animal diversity. He has received the Benjamin Franklin Medal in Life Sciences, been elected a member of the National Academy of Sciences, the American Philosophical Society, the European Molecular Biology Organization, as well as a Fellow of the American Academy of Arts and Sciences. Sean is the author of five books for general audiences including "The Serengeti Rules," "Brave Genius," "The Making of the Fittest," "Endless Forms Most Beautiful" and "Remarkable Creatures," which was a finalist for the National Book Award for non-fiction. In 2016, Sean received the Lewis Thomas Prize for Writing about Science.

The architect of HHMI’s documentary film initiative, Sean has served as executive
producer and/or on-screen presenter of more than a dozen films, including "Mass Extinction," "Amazon Adventure," and "The Farthest," and earned one Emmy and two Emmy nominations. His latest book, "The Serengeti Rules," is the basis for a new theatrical film being released in 2019.

View YouTube video of seminar: https://youtu.be/ppi7Xwro4PA

]]>
Workshop / Seminar Tue, 30 Apr 2019 12:23:17 -0400 2019-04-10T12:00:00-04:00 2019-04-10T13:00:00-04:00 Chemistry Dow Lab Ecology and Evolutionary Biology Workshop / Seminar rattlesnake
Selective Functionalization of Pyridines, Diazines and Pharmaceuticals via Heterocyclic Phosphonium Salt (April 10, 2019 4:00pm) https://events.umich.edu/event/61846 61846-15219414@events.umich.edu Event Begins: Wednesday, April 10, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Selective methods that can functionalize electron-deficient heterocycles are in great demand due to their prevalence in biologically active compounds. Pyridines and diazines, in particular, are widespread components of pharmaceutical compounds yet methods to transform these motifs into valuable derivatives are still greatly sought after. We will present a selection of catalytic and non-catalytic methods using phosphorus intermediates that enable multiple new bond-constructions on these heterocycles. A particular emphasis will be placed on phosphorus ligand-coupling reactions that represent an alternative means to form C–C and C-Heteroatom bonds.












Andy McNally (Colorado State University)

]]>
Other Wed, 10 Apr 2019 18:15:24 -0400 2019-04-10T16:00:00-04:00 2019-04-10T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Nanoscale Imaging of Chemical Reactivity using Single-Particle Fluorescence Microscopy (April 11, 2019 4:00pm) https://events.umich.edu/event/52808 52808-13081673@events.umich.edu Event Begins: Thursday, April 11, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

I will describe our group’s efforts to understand heterogeneity in the chemical reactivity of semiconductor nanocrystals by imaging reaction events one at a time. In one project, we have used the change in fluorescence intensity to image the transformation of individual lead bromide (PbBr2) nanocrystals to methylammonium lead bromide (CH3NH3PbBr3) via intercalation of CH3NH3Br. Analyzing this reaction one nanocrystal at a time reveals information that is masked when the fluorescence intensity is averaged over many particles. Sharp rises in the intensity of single nanocrystals indicate they transform much faster than the time it takes for the ensemble average to transform. Based on these observations, we propose a phase-transformation model in which the solid-state immiscibility between PbBr2 and CH3NH3PbBr3 initially create a high energy barrier for ion intercalation.
In related work, we have used chemically-triggered fluorogenic probes to study the spatial distribution of catalytically active regions in individual tungsten oxide nanowires using super-resolution fluorescence microscopy. Activation of the first probe molecule requires photoexcitation above the bandgap of the semiconductor to generate hydroxyl radicals. The second reaction does not require photoexcitation but instead relies on the presence of either oxygen vacancies or hydroxyl groups at the surface of the nanowires. Through quantitative, coordinate-based colocalization of probe molecules activated by the same nanowires, we demonstrate that the nanoscale regions most active for the photocatalytic generation of hydroxyl radicals also possess a greater concentration of oxygen vacancies.









Bryce Sadtler (Washington University in St. Louis)

]]>
Other Thu, 11 Apr 2019 18:15:27 -0400 2019-04-11T16:00:00-04:00 2019-04-11T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Titile: 'Structural Biology in situ: The Promise and Challenges of Cryo-Electron Tomography‘ (April 12, 2019 4:00pm) https://events.umich.edu/event/62526 62526-15397102@events.umich.edu Event Begins: Friday, April 12, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Oncley Lecture Series

]]>
Workshop / Seminar Mon, 25 Mar 2019 09:29:31 -0400 2019-04-12T16:00:00-04:00 2019-04-12T17:30:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
Thesis Defense: "Investigating the Substrate Selectivity and Regulation of Histone Deacetylases" (April 15, 2019 12:30pm) https://events.umich.edu/event/62810 62810-15470940@events.umich.edu Event Begins: Monday, April 15, 2019 12:30pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Katy Leng (Advisor: Prof.Carol Fierke)

]]>
Other Mon, 15 Apr 2019 18:15:16 -0400 2019-04-15T12:30:00-04:00 2019-04-15T13:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
"Mining the Innate Immune System for Novel Therapeutic Targets " (April 15, 2019 4:00pm) https://events.umich.edu/event/61932 61932-15241338@events.umich.edu Event Begins: Monday, April 15, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Gary Glick

]]>
Other Mon, 15 Apr 2019 18:15:16 -0400 2019-04-15T16:00:00-04:00 2019-04-15T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: “Some More Spectroscopy on Vitamin B 12 ” (April 16, 2019 12:15pm) https://events.umich.edu/event/62811 62811-15470941@events.umich.edu Event Begins: Tuesday, April 16, 2019 12:15pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Nick Miller (Advisor: Prof. Roseanne Sension)

]]>
Other Tue, 16 Apr 2019 18:15:24 -0400 2019-04-16T12:15:00-04:00 2019-04-16T13:15:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Supporting students’ understanding of models and modeling in general chemistry (April 16, 2019 4:00pm) https://events.umich.edu/event/62975 62975-15528486@events.umich.edu Event Begins: Tuesday, April 16, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Undergraduate general chemistry courses typically feature a substantial amount of problem solving that involve mathematical and other types of models. Optimally, this type of activity would provide them an entry point into the scientific practice of constructing and using models. But, evidence shows that after participating in traditional approaches to general chemistry students tend to approach mathematical problem solving algorithmically and may struggle to connect mathematical representations to particulate-level ideas. The question becomes: How can we as instructors support students in more meaningful engagement with mathematical and other models in chemistry contexts? Here, we discuss findings from our research into students’ reasoning about different types of models in the general chemistry sequence and discuss potential routes towards promoting more meaningful engagement in model-based reasoning and mathematical thinking.











Nicole Becker (University of Iowa)

]]>
Other Tue, 16 Apr 2019 18:15:24 -0400 2019-04-16T16:00:00-04:00 2019-04-16T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Radical reactions for control freaks: New synthetic methods involving aryl radicals and strong C–F bonds (April 17, 2019 4:00pm) https://events.umich.edu/event/58115 58115-14426735@events.umich.edu Event Begins: Wednesday, April 17, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Over the past few years, our group has utilized photoredox catalysis to access highly-reactive radical intermediates. Our broader aims are centered on utilizing these intermediates to deliver structural motifs that are commonly found in drugs and agrochemicals. This lecture will include recent findings that have enabled us to overcome inherent difficulties in aryl radical reactivity, allowing for the development of highly chemoselective and switchable processes. Importantly, these studies have enabled the development of many other selective processes, including strategies for peptide functionalization and activation of very strong C–F bonds.











Nathan Jui (Emory University)

]]>
Other Wed, 17 Apr 2019 18:15:25 -0400 2019-04-17T16:00:00-04:00 2019-04-17T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Super-Resolution Microscopy Made Simple (April 18, 2019 4:00pm) https://events.umich.edu/event/52763 52763-13023548@events.umich.edu Event Begins: Thursday, April 18, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


The Vaughan group develops new chemical tools for high resolution fluorescence microscopy and uses these tools, along with established ones, to understand the organization of biological systems with rich molecular detail. On the tool development side, we are synthesizing new fluorescent probes, creating new methods for tissue expansion and clearing, and developing assays to understand the organization of the genome. On the application side, we have partnered with biologists and pathologists to study the cytoskeleton, the organization of mouse and human kidney, and immune cell development. In my talk, I will discuss our recent work on the development and application of chemical tools for biological imaging.















Joshua Vaughan (University of Washington)

]]>
Other Thu, 18 Apr 2019 18:15:23 -0400 2019-04-18T16:00:00-04:00 2019-04-18T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: "Development of Methods for Introducing Fluorine Groups to Small Molecules" (April 19, 2019 10:00am) https://events.umich.edu/event/62960 62960-15522187@events.umich.edu Event Begins: Friday, April 19, 2019 10:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Devin Ferguson (Advisor: Prof. Melanie Sanford)

]]>
Other Fri, 19 Apr 2019 18:15:19 -0400 2019-04-19T10:00:00-04:00 2019-04-19T11:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Materials Chemistry Students 3rd Year Research Seminars (April 19, 2019 12:00pm) https://events.umich.edu/event/62976 62976-15528487@events.umich.edu Event Begins: Friday, April 19, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Nathaniel Hardin, Jessi Wilson

]]>
Other Fri, 19 Apr 2019 18:15:19 -0400 2019-04-19T12:00:00-04:00 2019-04-19T13:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: "“Development of the Silicon Photonic Microring Resonator Platform with Applications for the Detection of Nucleic Acids and Other Biopolymers” (April 19, 2019 1:00pm) https://events.umich.edu/event/62062 62062-15284705@events.umich.edu Event Begins: Friday, April 19, 2019 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Maria Cardenosa Rubio (Thesis Advisor: Prof. Ryan C. Bailey)

]]>
Other Fri, 19 Apr 2019 18:15:19 -0400 2019-04-19T13:00:00-04:00 2019-04-19T14:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
TBA (April 19, 2019 4:00pm) https://events.umich.edu/event/62971 62971-15526387@events.umich.edu Event Begins: Friday, April 19, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Conventional macromolecular crystallographic refinement relies on stereochemistry restraints and a rudimentary energy functional to ensure the correct geometry of the model of the macromolecule, along with any bound ligand(s), within the experimental, X-ray density. Traditionally, these highly approximate methods lack explicit, rigorous terms for electrostatics, polarization, dispersion, hydrogen bonds, and other interactions, and they often rely on pre-determined parameters to capture the a priori understanding of the structure. In order to address this deficiency and capture a more complete understanding of the structure, we have developed a fully automated approach for macromolecular refinement based on a two layer, QM/MM (ONIOM) scheme implemented within our DivCon Suite which has been "plugged in" to two mainstream crystallographic packages: PHENIX[1] and BUSTER. This implementation consists of one or more "region layer(s)" characterized using linear-scaling, semi-empirical quantum mechanics, coupled with a "system layer" encompassing the rest of the protein described with a molecular mechanics functional[2].
Armed with a more accurate tool, we not only gain a better understanding of overall protein:ligand structure, but we can also use X-ray data to correctly determine active site tautomer/protomer states[3] and water site locations.
In this talk, we will discuss these methods and explore their impact in the context of binding affinity prediction and structure-based drug discovery.

]]>
Workshop / Seminar Tue, 09 Apr 2019 08:51:59 -0400 2019-04-19T16:00:00-04:00 2019-04-19T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
New methods and strategies in the synthesis of natural products (April 22, 2019 4:00pm) https://events.umich.edu/event/61881 61881-15225983@events.umich.edu Event Begins: Monday, April 22, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

New methods and strategies in the synthesis of terpenoid and polyketide natural products will be discussed.




Sergey Pronin (UC Irvine)

]]>
Other Mon, 22 Apr 2019 18:15:12 -0400 2019-04-22T16:00:00-04:00 2019-04-22T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Chemical Regulation of Functional RNAs (April 23, 2019 4:00pm) https://events.umich.edu/event/55268 55268-13711531@events.umich.edu Event Begins: Tuesday, April 23, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

We study the mechanisms of specificity and regulation of enzymes that act on RNA. We identified the molecular basis for how a small molecule, heme, affects microRNA processing enzyme Drosha. We show that heme acts as a signaling factor to switch on processing of a subset of microRNAs. Other chemicals such as S-adenosylmethioinine, and transfer of its methyl group to RNA, can also have a big role in RNA-mediated gene regulation. We show the mechanistic details of how RNA methylation is accomplished, using crystal structures and biochemical studies.








Yunsun Nam (UT Southwestern Medical Center)

]]>
Other Tue, 23 Apr 2019 18:15:14 -0400 2019-04-23T16:00:00-04:00 2019-04-23T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Biophysics Symposium (April 24, 2019 8:00am) https://events.umich.edu/event/62917 62917-15494569@events.umich.edu Event Begins: Wednesday, April 24, 2019 8:00am
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Protein-protein interactions among Bcl-2 family proteins regulate apoptosis. Anti-apoptotic members of the family, including Bcl-2, Bcl-xL, Bcl-w, Mcl-1, and Bfl-1, sequester pro-apoptotic family members by binding tightly to an amphipathic alpha helix within them, blocking pro-death functions. Through this mechanism, overexpression of the anti-apoptotic proteins is implicated in oncogenesis and resistance to chemotherapy. Tight-binding and selective inhibitors of Bcl-2 family proteins can be used to diagnose the Bcl-2 dependencies of cancer cells and may be developed as therapeutics. The challenge of designing peptides that function as high-affinity and selective inhibitors of specific Bcl-2 family proteins poses a fundamental, challenging problem in protein engineering and a good opportunity to study principles of protein-peptide recognition. I will describe features of Bcl-2 family protein interactions and discuss approaches we have developed that integrate computational structure-based modeling with high-throughput screening to generate peptide-based inhibitors.

Register here: https://sites.lsa.umich.edu/biophysics-symposium/2019-biophysics-symposium-registration/

]]>
Conference / Symposium Wed, 10 Apr 2019 12:42:37 -0400 2019-04-24T08:00:00-04:00 2019-04-24T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Conference / Symposium Chemistry Dow Lab
Materials Chemistry Students 3rd Year Research Seminars (April 24, 2019 1:15pm) https://events.umich.edu/event/62993 62993-15530603@events.umich.edu Event Begins: Wednesday, April 24, 2019 1:15pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




William Dean, Matthew Hannigan, Quintin Cheek, Samuel Michaud, Jinhee Kim

]]>
Other Wed, 24 Apr 2019 18:15:12 -0400 2019-04-24T13:15:00-04:00 2019-04-24T16:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
The Riddler: Exploring the Structure-Function-Stability Relationship in Organic Electronic Materials (April 25, 2019 1:00pm) https://events.umich.edu/event/62251 62251-15337487@events.umich.edu Event Begins: Thursday, April 25, 2019 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Coming soon ....








Jeanne Pemberton (University of Arizona)

]]>
Other Thu, 25 Apr 2019 18:15:12 -0400 2019-04-25T13:00:00-04:00 2019-04-25T14:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: “Synthesis and Spectroscopic Characterization of Ferric Heme-Thiolate Complexes and their Reactivity with NO as Models for Cytochrome P450 Nitric Oxide Reductase” (April 25, 2019 1:00pm) https://events.umich.edu/event/63050 63050-15539038@events.umich.edu Event Begins: Thursday, April 25, 2019 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Andrew P. Hunt (Advisor: Prof. Nicolai Lehnert)

]]>
Other Thu, 25 Apr 2019 18:15:12 -0400 2019-04-25T13:00:00-04:00 2019-04-25T14:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
TBA (April 25, 2019 4:00pm) https://events.umich.edu/event/59508 59508-14748067@events.umich.edu Event Begins: Thursday, April 25, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry














Aniruddha Ray (University of Toledo)

]]>
Other Fri, 29 Mar 2019 06:15:39 -0400 2019-04-25T16:00:00-04:00 2019-04-25T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: "New Reactivity Modes between Carbonyls and Olefins: Catalytic Carbonyl-Olefin Metathesis and Oxygen Atom Transfer" (April 26, 2019 12:00pm) https://events.umich.edu/event/62962 62962-15522189@events.umich.edu Event Begins: Friday, April 26, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Rebecca Watson (Advisor: Prof. Corinna Schindler)

]]>
Other Fri, 26 Apr 2019 18:15:13 -0400 2019-04-26T12:00:00-04:00 2019-04-26T13:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: "Automated Reaction Discovery to Understand Chemical Reactivity" (April 26, 2019 3:00pm) https://events.umich.edu/event/62961 62961-15522188@events.umich.edu Event Begins: Friday, April 26, 2019 3:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Amanda Dewyer (Advisor: Prof. Paul Zimmerman)

]]>
Other Fri, 26 Apr 2019 18:15:12 -0400 2019-04-26T15:00:00-04:00 2019-04-26T16:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Philicities, Fugalities, and Equilibrium Constants: (April 29, 2019 4:00pm) https://events.umich.edu/event/52990 52990-13170378@events.umich.edu Event Begins: Monday, April 29, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our understanding of polar organic reactivity is based on relationships between rate and equilibrium constants. Thus, strong bases are generally considered to be good nucleophiles as well as poor nucleofuges. Though exceptions from this general rule have long been known, a systematic analysis has been problematic, because rate constants for the reactions of nucleophiles with C-centered electrophiles have often been correlated with Brønsted basicities (i. e., affinities towards the proton). For that reason, the origin of deviations from Brønsted correlations could often not unambiguously be assigned.



In the last two decades, we have created comprehensive nucleophilicity,1 nucleofugality,2 and Lewis basicity scales3 by using differently substituted benzhydrylium ions with widely variable reactivity but equal steric demand as reference electrophiles,1 electrofuges,2 and Lewis acids.3 Relationships between these kinetic and thermodynamic parameters will be discussed with emphasis on examples where the commonly assumed proportionalities break down.4
I will discuss the origin of several counterintuitive phenomena, e.g. why strong nucleophiles can also be good nucleofuges, and why weak nucleophiles sometimes substitute strong nucleophiles in SN2 reactions. It will be shown that solvolysis rate constants of alkyl bromides and chlorides, but not of carboxylates provide accurate information about thermodynamic stabilities (more precise: Lewis acidities) of carbocations. Eventually it will be discussed why carbocations, which are formed slowly in SN1 reactions are not always good electrophiles.5 The role of intrinsic barriers for controlling organic reactivity will be analyzed.

1. (a) H. Mayr, A. R. Ofial, J. Phys. Org. Chem. 2008, 21, 584
(b) Data base: http://www.cup.uni-muenchen.de/oc/mayr/DBintro.html.
2. Streidl, N.; Denegri, B.; Kronja, O.; Mayr, H.; Acc. Chem. Res. 2010, 43, 1537-1549.
3. Mayr, H.; Ammer, J.; Baidya, M.; Maji, B.; Nigst, T. A.; Ofial, A. R.; Singer, T.; J. Am. Chem. Soc. 2015, 137, 2580-2599.
4. Mayr, H.; Ofial, A. R.; Acc. Chem. Res. 2016, 49, 952-965.
5. Byrne, P.A.; Kobayashi, S.; Würthwein, E.-U.; Ammer, J.; Mayr H. J. Am. Chem. Soc. 2017, 139, 1499-1511.









Herbert Mayr (Ludwig-Maximilians-Universitaet Muenchen)

]]>
Other Mon, 29 Apr 2019 18:15:08 -0400 2019-04-29T16:00:00-04:00 2019-04-29T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Chemical Approaches to Interrogating the Transcriptome (April 30, 2019 4:00pm) https://events.umich.edu/event/61059 61059-15027186@events.umich.edu Event Begins: Tuesday, April 30, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


Although once regarded as a transient messenger of genetic information, novel and exciting roles played by RNA inside cells continue to be revealed. Nevertheless, as the list of cataloged RNAs expands there is a parallel lag in our understanding of the mechanistic basis of many RNA functions. This is in many ways due to a dearth of precise biochemical methods to understand RNA expression, structure, and function. Within this seminar I will detail our lab’s efforts to bring the power of chemistry to bare on these challenges, with particular focus on developing novel chemical reactions to measure RNA structure and chemical genetic approaches to assay RNA expression in a cell-specific manner.











Robert Spitale (University of California Irvine)

]]>
Other Tue, 30 Apr 2019 18:15:07 -0400 2019-04-30T16:00:00-04:00 2019-04-30T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: “New Strategies for Carbonyl-Olefin Metathesis” (May 1, 2019 11:00am) https://events.umich.edu/event/62812 62812-15470942@events.umich.edu Event Begins: Wednesday, May 1, 2019 11:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Jacob Ludwig (Advisor: Prof. Corinna Schindler)

]]>
Other Wed, 01 May 2019 18:15:14 -0400 2019-05-01T11:00:00-04:00 2019-05-01T12:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: Mechanistic studies on phosphoric acid-catalyzed acetalizations and development of acetal-containing ligands for transition metal catalysis" (May 2, 2019 10:00am) https://events.umich.edu/event/63019 63019-15536913@events.umich.edu Event Begins: Thursday, May 2, 2019 10:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Alonso J. Arguelles (Advisors: Pavel Nagorny & Paul Zimmerman)

]]>
Other Thu, 02 May 2019 18:15:08 -0400 2019-05-02T10:00:00-04:00 2019-05-02T11:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
MCDB Pathways Defense: A Non-Biased FFT Based Cellular Dynamics Software: Array Detection in Arabidopsis (May 2, 2019 1:00pm) https://events.umich.edu/event/63421 63421-15692039@events.umich.edu Event Begins: Thursday, May 2, 2019 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Nielsen Lab

]]>
Workshop / Seminar Mon, 29 Apr 2019 10:09:07 -0400 2019-05-02T13:00:00-04:00 2019-05-02T14:00:00-04:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar graphic showing results of applying software to plant image to highlight structural data
Thesis Defense: “The Development of Catalyzed Carbonyl-Olefin Metathesis and Oxygen Atom Transfer Reactions” (May 6, 2019 10:00am) https://events.umich.edu/event/62813 62813-15470943@events.umich.edu Event Begins: Monday, May 6, 2019 10:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Haley Albright (Advisor: Prof. Corinna Schindler)

]]>
Other Mon, 06 May 2019 18:15:08 -0400 2019-05-06T10:00:00-04:00 2019-05-06T11:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Celgene Lecture Symposium (May 6, 2019 1:00pm) https://events.umich.edu/event/61858 61858-15223782@events.umich.edu Event Begins: Monday, May 6, 2019 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Oxidation and reduction reactions are among the most important and frequently executed processes in organic synthesis. However, our ability to manipulate the oxidation states of functional groups in complex settings with high efficiency, precision, and minimal waste remains in a largely nascent stage. Owing to its many distinct characteristics, electrochemistry represents an attractive approach to meet the prevailing trends in organic synthesis. In particular, electrocatalysis—a process that integrates electrochemistry and small-molecule catalysis—has the potential to substantially improve the scope of synthetic electrochemistry and provide a wide range of useful transformations. Despite its attractive attributes and extensive applications in energy-related fields, electrocatalysis has been used only sparingly in synthetic organic chemistry. Toward this end, we developed a new catalytic approach that combines electrochemistry and redox-metal catalysis for the oxidative difunctionalization of alkenes to access a diverse array of vicinally functionalized structures. This presentation will detail our design principle underpinning the development of electrocatalytic alkene diazidation, dichlorination, halotrifluoromethylation, haloalkylation, and cyanophosphonylation.


Larry Hamann(Celgene) , Donna Huryn(University of Pittsburgh) , Song Lin(Cornell University)

]]>
Other Mon, 06 May 2019 18:15:07 -0400 2019-05-06T13:00:00-04:00 2019-05-06T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
"Elucidating RNA structure and the molecular recognition properties of multi-domain enzymes: nucleic acid binding interactions at the chromatin interface" (May 7, 2019 4:00pm) https://events.umich.edu/event/55269 55269-13711532@events.umich.edu Event Begins: Tuesday, May 7, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry
















Nick Reiter (Marquette University)

]]>
Other Tue, 07 May 2019 18:15:08 -0400 2019-05-07T16:00:00-04:00 2019-05-07T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: "Methods and Informatics to Analyze Intact Protein Sequence and Structure by Ion Mobility-Mass Spectrometry (May 8, 2019 12:00pm) https://events.umich.edu/event/62963 62963-15522190@events.umich.edu Event Begins: Wednesday, May 8, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Daniel Polasky (Advisor: Brandon Ruotolo)

]]>
Auditions Wed, 08 May 2019 18:15:08 -0400 2019-05-08T12:00:00-04:00 2019-05-08T13:00:00-04:00 Chemistry Dow Lab Department of Chemistry Auditions Chemistry Dow Lab
Thesis Defense: “Microfluidic Technologies for Bioanalytical Chemistry: Advancing Epigenetic Profiling via Chromatin Immunoprecipitation in Droplets” (May 9, 2019 2:00pm) https://events.umich.edu/event/63207 63207-15589332@events.umich.edu Event Begins: Thursday, May 9, 2019 2:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Steven R. Doonan (Advisor: Prof. Ryan C. Bailey)

]]>
Other Thu, 09 May 2019 18:15:10 -0400 2019-05-09T14:00:00-04:00 2019-05-09T15:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Improving Efficiency Through Catalytic and Multicatalytic Reactions (May 9, 2019 4:00pm) https://events.umich.edu/event/58954 58954-14623975@events.umich.edu Event Begins: Thursday, May 9, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry














Mark Lautens (U Toronto)

]]>
Other Thu, 09 May 2019 18:15:10 -0400 2019-05-09T16:00:00-04:00 2019-05-09T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: "Photo- and Electrochemical Methods for Biomass Valorization" (May 10, 2019 10:00am) https://events.umich.edu/event/63367 63367-15661293@events.umich.edu Event Begins: Friday, May 10, 2019 10:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Gabriel Magallanes (Thesis Advisor: Prof. Corey Stephenson)

]]>
Other Fri, 10 May 2019 18:15:11 -0400 2019-05-10T10:00:00-04:00 2019-05-10T11:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Cayman Symposium (May 16, 2019 10:00am) https://events.umich.edu/event/63616 63616-15816687@events.umich.edu Event Begins: Thursday, May 16, 2019 10:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




















Daniel Nomura(UC Berkeley) , Dustin Maly(U. Washington)

]]>
Other Thu, 16 May 2019 18:15:14 -0400 2019-05-16T10:00:00-04:00 2019-05-16T16:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Reinventing Drug Discovery through Chemical Biology (May 16, 2019 10:00am) https://events.umich.edu/event/63351 63351-15653094@events.umich.edu Event Begins: Thursday, May 16, 2019 10:00am
Location: Chemistry Dow Lab
Organized By: U-M College of Pharmacy

Sponsored by Cayman Chemical

Keynote lectures from Profs. Dusty Maly (Univ. of Washington; http://depts.washington.edu/malylab/wordpress/) and Daniel Nomura (UC Berkeley; http://nomuraresearchgroup.com).

Additional lectures from U-M faculty Profs. Matt Soellner, Amanda Garner, Nouri Neamati and Jolanta Grembecka.

A poster session and catered lunch will be held from 12-1:30 PM.

Two poster presenters will be invited to give a short talk about their research.

Please RSVP by May 9.

]]>
Lecture / Discussion Wed, 24 Apr 2019 15:13:38 -0400 2019-05-16T10:00:00-04:00 2019-05-16T16:00:00-04:00 Chemistry Dow Lab U-M College of Pharmacy Lecture / Discussion Chemistry Dow Lab
Scientific publishing from the inside out (May 17, 2019 12:00pm) https://events.umich.edu/event/63182 63182-15587256@events.umich.edu Event Begins: Friday, May 17, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

For over 130 years, Science Magazine has presented a weekly selection of the finest research across the full spectrum of scientific disciplines. Our goal remains to keep scientists well-informed about important developments within and also beyond their own fields of research, and to encourage collaborative thinking. This talk will discuss how the staff at Science engages the research community all over the world to determine which papers to publish, and also how we envision maintaining and enhancing our value to the community in the rapidly evolving publication landscape.









Jake Yeston (Science)

]]>
Other Fri, 17 May 2019 18:15:10 -0400 2019-05-17T12:00:00-04:00 2019-05-17T13:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Engaging Esters, Aldehydes, and Alcohols in Ni-Catalyzed Couplings: A High Throughput Approach to Reaction Discovery (May 24, 2019 12:00pm) https://events.umich.edu/event/62063 62063-15284706@events.umich.edu Event Begins: Friday, May 24, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Catalytic cross-coupling reactions that unite simple organic building blocks continue to increase in scope, utility, and frequency of use. Progress in this field stems from improved mechanistic understanding, development of new catalysts, and identification of new functional groups that can be activated and engaged in cross-couplings and related transformations. In this seminar, strategies to incorporate esters, aldehydes, and alcohols into Ni-catalyzed C-C and C-N forming reactions will be discussed. The discovery process will also be detailed, including how a rational, mechanism-guided approach can act in synergy with high throughput experimentation techniques.




Stephen Newman (University of Ottawa)

]]>
Other Thu, 09 May 2019 06:15:08 -0400 2019-05-24T12:00:00-04:00 2019-05-24T13:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
TBA (June 14, 2019 1:00pm) https://events.umich.edu/event/62814 62814-15470944@events.umich.edu Event Begins: Friday, June 14, 2019 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Due to the highly active radical intermediate, the organic transformation via radical pathway have been extensively studied. However, the selective control of radical intermediate is extremely challenging, which significantly retards the success of highly selective radical reaction, specially for the enantioselective version. Recently, Our group recently reveals that the stereoselective control of radical could be achieved by using copper catalyst, and a series of enantioselective difunctionalization of alkenes have been explored by using bisoxazoline (Box)/Cu(I) catalytic system. In these studies, a benzylic radical intermediate was involved in the catalytic cycles, which can be enantioselectively traped by (Box)/CuII intermediate to produce enantiomerically enriched products. In this talk, I'd like to introduced our recent progress in the asymmetric oxidative functionalization of C-H bonds, including benzylic and allylic C-H bonds, wherein copper catalyst plays important roles on the both site- and enantioselectivity.












Chaozhong Li(Shanghai Institute of Organic Chemistry) , Guosheng Liu(Shanghai Institute of Organic Chemistry)

]]>
Other Fri, 14 Jun 2019 18:15:14 -0400 2019-06-14T13:00:00-04:00 2019-06-14T15:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
"Purification and surface chemistry of colloidal nanocrystals and nanowires " (June 27, 2019 4:00pm) https://events.umich.edu/event/63769 63769-15873579@events.umich.edu Event Begins: Thursday, June 27, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Andrew Greytak

]]>
Other Thu, 27 Jun 2019 18:15:14 -0400 2019-06-27T16:00:00-04:00 2019-06-27T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
RSC Meet the Editor: Deconstructing Reaction Coordinates for Ultrafast Excited-state Dynamics: Using Coherence to Inform Synthetic Design (July 11, 2019 11:30am) https://events.umich.edu/event/63770 63770-15873580@events.umich.edu Event Begins: Thursday, July 11, 2019 11:30am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Jennifer Lee(Royal Society of Chemistry Worldwide (US) Inc.) , James McCusker

]]>
Other Thu, 11 Jul 2019 18:15:15 -0400 2019-07-11T11:30:00-04:00 2019-07-11T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
ALUM|NUM :: Alumni-Grad Networking, Graduate Awards Ceremony, Undergrad Poster Session & Reception (August 1, 2019 12:00pm) https://events.umich.edu/event/63725 63725-15833060@events.umich.edu Event Begins: Thursday, August 1, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

All alumni are welcome to come back to Michigan to join graduate students and postdocs for workshops on career, as well as the annual Graduate Student Awards ceremony. A reception follows the ceremony.
This annual event precedes the Karle Symposium on Friday, August 2.
Learn more on the ALUM|NUM and Karle websites.

]]>
Reception / Open House Tue, 30 Jul 2019 13:35:11 -0400 2019-08-01T12:00:00-04:00 2019-08-01T18:30:00-04:00 Chemistry Dow Lab Department of Chemistry Reception / Open House save the date poster
Karle Symposium (August 2, 2019 8:00am) https://events.umich.edu/event/63806 63806-15890342@events.umich.edu Event Begins: Friday, August 2, 2019 8:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Join us for the annual all-day showcase of research in the Department of Chemistry, organized and presented by our graduate students. The Symposium includes two keynote speakers, as well as a poster session and speakers from each Chemistry research cluster.
Registration opens June 10.
Get details at the Karle Symposium website: https://sites.lsa.umich.edu/karle-symposium/

]]>
Workshop / Seminar Wed, 05 Jun 2019 11:11:17 -0400 2019-08-02T08:00:00-04:00 2019-08-02T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Workshop / Seminar logo for symposium
Karle Symposium (August 2, 2019 9:00am) https://events.umich.edu/event/62708 62708-15434126@events.umich.edu Event Begins: Friday, August 2, 2019 9:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry












Phil Baran

]]>
Other Fri, 02 Aug 2019 18:15:18 -0400 2019-08-02T09:00:00-04:00 2019-08-02T18:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Biophysics Talk Title: Who Said To Do That? Understanding Multicellular Decision Making (August 8, 2019 11:30am) https://events.umich.edu/event/64265 64265-16274469@events.umich.edu Event Begins: Thursday, August 8, 2019 11:30am
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: One of the key outstanding challenges in understanding multicellular systems is identifying what single cells tune within themselves to change population-wide behaviors. A major driver of multicellular patterns is oscillations in single-cell signaling networks, but it is unknown what features single cells naturally modulate in these oscillations to change global patterns. An ideal system for addressing this challenge exists in the social amoeba, Dictyostelium discoideum. Dictyostelium uses travelling waves of cyclic AMP as a chemoattractant between cells to drive aggregation into a multicellular state when starving. These waves originate within single cells that release cyclic AMP to the environment, and the single-cell signaling network phenomena that drive the creation of these waves are well-characterized. Using new experimental data in conjunction with an existing phenomenological model, I explore what parameters single cells can modulate to control the properties of these signaling oscillations and the patterns they coordinate.

]]>
Workshop / Seminar Mon, 22 Jul 2019 14:33:39 -0400 2019-08-08T11:30:00-04:00 2019-08-08T12:30:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
Electrochemical Reshaping of Living Tissues: Non-Invasive Surgical Modalities for Reshaping Cartilage and Cornea (August 8, 2019 4:00pm) https://events.umich.edu/event/64479 64479-16372908@events.umich.edu Event Begins: Thursday, August 8, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Michael Hill (Occidental College)

]]>
Other Thu, 08 Aug 2019 18:15:24 -0400 2019-08-08T16:00:00-04:00 2019-08-08T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
CSIEUM - Workshop: Big Data in Pharma - Brainstorming a new 1-credit class (August 30, 2019 12:00pm) https://events.umich.edu/event/65519 65519-16607704@events.umich.edu Event Begins: Friday, August 30, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Marc Scanio (Abbvie)

]]>
Other Fri, 30 Aug 2019 18:15:31 -0400 2019-08-30T12:00:00-04:00 2019-08-30T13:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Pre-Health Student Orientation (A-L) (September 3, 2019 6:00pm) https://events.umich.edu/event/64017 64017-16065442@events.umich.edu Event Begins: Tuesday, September 3, 2019 6:00pm
Location: Chemistry Dow Lab
Organized By: University Career Center

A session for all incoming and transferring pre-health students. Gather tips for successful preparation for medical school and other health profession programs. Learn about resources and services available to you at the University of Michigan. Due to room capacity, the same session will be repeated from 7:30 PM to 8:30 PM. Please make every effort to attend the appropriate session according to your last name's initial; but do feel free to choose the other one if otherwise unable to attend. PLAN TO ARRIVE BY 5:30 PM TO CHECK IN. BRING UM STUDENT ID. The Pre-Health Orientation is sponsored by the UM University Career Center and the Newnan Advising Center.

]]>
Presentation Tue, 20 Aug 2019 12:00:39 -0400 2019-09-03T18:00:00-04:00 2019-09-03T19:00:00-04:00 Chemistry Dow Lab University Career Center Presentation Chemistry Dow Lab
Pre-Health Student Orientation (M-Z) (September 3, 2019 7:30pm) https://events.umich.edu/event/64018 64018-16065443@events.umich.edu Event Begins: Tuesday, September 3, 2019 7:30pm
Location: Chemistry Dow Lab
Organized By: University Career Center

A session for all incoming and transferring pre-health students. Gather tips for successful preparation for medical school and other health profession programs. Learn about resources and services available to you at the University of Michigan. Due to room capacity, the same session will also be offered from 6:00 PM to 7:00 PM. Please make every effort to attend the appropriate session according to your last name's initial; but do feel free to choose the other one if otherwise unable to attend. PLAN TO ARRIVE BY 7:00 PM TO CHECK IN. BRING UM STUDENT ID. The Pre-Health Student Orientation is sponsored by the UM University Career Center and the Newnan Advising Center.

]]>
Presentation Tue, 20 Aug 2019 11:59:41 -0400 2019-09-03T19:30:00-04:00 2019-09-03T20:30:00-04:00 Chemistry Dow Lab University Career Center Presentation Chemistry Dow Lab
Increasing Molecular Coverage in Complex Biological & Environmental Samples Using Ion Mobility-Mass Spectrometry (September 5, 2019 4:00pm) https://events.umich.edu/event/64170 64170-16179703@events.umich.edu Event Begins: Thursday, September 5, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


Mass spectrometry (MS)-based technologies are playing a growing role in the analysis of complex samples. Despite significant advances in MS technology, currently it is difficult to obtain measurements of both high throughput and high sensitivity for samples with great dynamic ranges such as biofluids and plant extracts. This problem ultimately results in the inability to effectively account for variation among sample conditions and/or biodiversity leading to inconsequential findings for samples which have great variation. To address this challenge, we have coupled an ion mobility separation (IMS) with MS to afford greatly improved measurement throughput, sensitivity, robustness, and quantitative capabilities for rapid analysis of complex samples. The benefits we have observed in omic studies of biological and environmental samples with IMS-MS will be summarized in this presentation.





Erin Baker (NC State)

]]>
Other Thu, 05 Sep 2019 18:15:31 -0400 2019-09-05T16:00:00-04:00 2019-09-05T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Biophysics Talk Title: TBD (September 6, 2019 12:00pm) https://events.umich.edu/event/64280 64280-16274491@events.umich.edu Event Begins: Friday, September 6, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstracts: TBD

]]>
Workshop / Seminar Wed, 10 Jul 2019 11:26:22 -0400 2019-09-06T12:00:00-04:00 2019-09-06T13:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
From fluctuations to function: The role of dynamics in the mechanism and regulation of translation (September 10, 2019 4:00pm) https://events.umich.edu/event/63255 63255-15603733@events.umich.edu Event Begins: Tuesday, September 10, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Over the past two decades, stunning breakthroughs in the field of structural biology have continued to produce groundbreaking high-resolution structures of large, multi-component biomolecular machines. Comparative analyses of these static structures reveals the remarkable conformational flexibility of these machines and hints at the significant structural rearrangements that evidently accompany their functional cycles. Unfortunately, the experimental observation and characterization of these conformational dynamics is severely impeded by the size and complexity of biomolecular machines, severely limiting our understanding of the contributions that dynamics make to their functions. Using a combination of single-molecule biophysical-, structural-, and biochemical approaches, my research group aims to overcome these challenges and elucidate the precise roles that the conformational dynamics of biomolecular machines play in driving and controlling their functions. My seminar presentation will primarily focus on our studies of the mechanism and regulation of messenger RNA translation into protein by the ribosome, an essential step in gene expression. Specifically, I will discuss how thermally driven fluctuations of the ribosome and other essential translation components contribute to the mechanism and regulation of translation. Because the ribosome is the target of over half of all currently prescribed antibiotics and because of the growing list of human diseases to which deregulation of translation has been causally linked, our findings hold great promise for informing the development of next-generation antibiotics and small-molecule therapeutic agents that function by modulating the conformational dynamics of the translation machinery. Building on what we have learned from these studies, I will close my presentation by describing recent technological advances that are allowing us to investigate biomolecular dynamics which play important roles in biological mechanisms, but that have thus far remained difficult or impossible to investigate.




Ruben Gonzalez (Columbia University)

]]>
Other Tue, 10 Sep 2019 18:15:37 -0400 2019-09-10T16:00:00-04:00 2019-09-10T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Sundaes on Tuesday (September 10, 2019 6:30pm) https://events.umich.edu/event/65533 65533-16611708@events.umich.edu Event Begins: Tuesday, September 10, 2019 6:30pm
Location: Chemistry Dow Lab
Organized By: Women in Science and Engineering (WISE) Program

WISE invites incoming freshman considering STEM majors to an ice cream extravaganza. Meet people who share your passion, learn about the resources on campus for STEM students, and make some delicious sundaes. Vegan options available!

]]>
Social / Informal Gathering Fri, 30 Aug 2019 09:05:12 -0400 2019-09-10T18:30:00-04:00 2019-09-10T20:00:00-04:00 Chemistry Dow Lab Women in Science and Engineering (WISE) Program Social / Informal Gathering Ice cream sundae
Pushing the Limits: Mass Spectrometry of Arctic Atmospheric Chemistry (September 12, 2019 4:00pm) https://events.umich.edu/event/64128 64128-16165588@events.umich.edu Event Begins: Thursday, September 12, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Kerri Pratt (University of Michigan)

]]>
Other Thu, 12 Sep 2019 18:15:35 -0400 2019-09-12T16:00:00-04:00 2019-09-12T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Boron Cluster Building Blocks and Synthetic Reagents (September 17, 2019 4:00pm) https://events.umich.edu/event/65046 65046-16509306@events.umich.edu Event Begins: Tuesday, September 17, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry



TBD




Alexander Spokoyny (UCLA)

]]>
Other Tue, 17 Sep 2019 18:15:51 -0400 2019-09-17T16:00:00-04:00 2019-09-17T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Unconventional techniques of imaging and microscopy for bio-medical applications. (September 19, 2019 4:00pm) https://events.umich.edu/event/62913 62913-15494564@events.umich.edu Event Begins: Thursday, September 19, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


Over the last few years a significant effort has been directed towards unconventional imaging techniques, such as microscopy without lenses as it can overcome some of the drawbacks associated with tradition optical microscopy, that rely on objective lenses, which results in a trade-off between the field of view and the resolution. Thus lens-less microscopy allows imaging and analysis over a wide area, enabling high throughput measurements, in addition to being cost-effective and portable. In this type of microscopy, the images are computationally reconstructed from in-line holograms, which result from the interference between the scattered optical wave from the sample and the directly transmitted wave. Here, I will present about lens-free on-chip microscopy designs, image reconstruction and its utility towards a wide range of applications related to sizing of nanoparticles, nanoparticle-aggregation, bio-sensing of pathogens and rare cancer cells, characterization of polymer degradation, material properties and rheology.











Aniruddha Ray

]]>
Other Thu, 19 Sep 2019 18:15:48 -0400 2019-09-19T16:00:00-04:00 2019-09-19T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Biophysics Talk Title: "Emerging methods in solution NMR and applications to illuminate blind spots in human biology” (September 20, 2019 12:00pm) https://events.umich.edu/event/64267 64267-16274479@events.umich.edu Event Begins: Friday, September 20, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: TBD

]]>
Workshop / Seminar Wed, 04 Sep 2019 14:42:29 -0400 2019-09-20T12:00:00-04:00 2019-09-20T13:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
CSIEUM - Seminar TBD (September 20, 2019 4:00pm) https://events.umich.edu/event/64957 64957-16495250@events.umich.edu Event Begins: Friday, September 20, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

ChemEd
Darryl Boyd

]]>
Other Fri, 20 Sep 2019 18:15:47 -0400 2019-09-20T16:00:00-04:00 2019-09-20T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Dr. Kevin Wood Tenure Talk (September 20, 2019 4:00pm) https://events.umich.edu/event/67138 67138-16805204@events.umich.edu Event Begins: Friday, September 20, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: TBD

]]>
Workshop / Seminar Fri, 13 Sep 2019 12:28:49 -0400 2019-09-20T16:00:00-04:00 2019-09-20T17:30:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
Gateway NMR Meeting (September 21, 2019 8:00am) https://events.umich.edu/event/64651 64651-16404987@events.umich.edu Event Begins: Saturday, September 21, 2019 8:00am
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Registration: https://sites.google.com/umich.edu/gatewaynmr2019/home

]]>
Meeting Fri, 26 Jul 2019 15:01:32 -0400 2019-09-21T08:00:00-04:00 2019-09-21T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Meeting Chemistry Dow Lab
Gateway NMR Meeting (September 22, 2019 8:00am) https://events.umich.edu/event/64651 64651-16404988@events.umich.edu Event Begins: Sunday, September 22, 2019 8:00am
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Registration: https://sites.google.com/umich.edu/gatewaynmr2019/home

]]>
Meeting Fri, 26 Jul 2019 15:01:32 -0400 2019-09-22T08:00:00-04:00 2019-09-22T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Meeting Chemistry Dow Lab