Happening @ Michigan https://events.umich.edu/list/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. ALUM|NUM :: Alumni-Grad Networking, Graduate Awards Ceremony, Undergrad Poster Session & Reception (August 1, 2019 12:00pm) https://events.umich.edu/event/63725 63725-15833060@events.umich.edu Event Begins: Thursday, August 1, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

All alumni are welcome to come back to Michigan to join graduate students and postdocs for workshops on career, as well as the annual Graduate Student Awards ceremony. A reception follows the ceremony.
This annual event precedes the Karle Symposium on Friday, August 2.
Learn more on the ALUM|NUM and Karle websites.

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Reception / Open House Tue, 30 Jul 2019 13:35:11 -0400 2019-08-01T12:00:00-04:00 2019-08-01T18:30:00-04:00 Chemistry Dow Lab Department of Chemistry Reception / Open House save the date poster
Karle Symposium (August 2, 2019 8:00am) https://events.umich.edu/event/63806 63806-15890342@events.umich.edu Event Begins: Friday, August 2, 2019 8:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Join us for the annual all-day showcase of research in the Department of Chemistry, organized and presented by our graduate students. The Symposium includes two keynote speakers, as well as a poster session and speakers from each Chemistry research cluster.
Registration opens June 10.
Get details at the Karle Symposium website: https://sites.lsa.umich.edu/karle-symposium/

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Workshop / Seminar Wed, 05 Jun 2019 11:11:17 -0400 2019-08-02T08:00:00-04:00 2019-08-02T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Workshop / Seminar logo for symposium
Karle Symposium (August 2, 2019 9:00am) https://events.umich.edu/event/62708 62708-15434126@events.umich.edu Event Begins: Friday, August 2, 2019 9:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry












Phil Baran

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Other Fri, 02 Aug 2019 18:15:18 -0400 2019-08-02T09:00:00-04:00 2019-08-02T18:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Biophysics Talk Title: Who Said To Do That? Understanding Multicellular Decision Making (August 8, 2019 11:30am) https://events.umich.edu/event/64265 64265-16274469@events.umich.edu Event Begins: Thursday, August 8, 2019 11:30am
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: One of the key outstanding challenges in understanding multicellular systems is identifying what single cells tune within themselves to change population-wide behaviors. A major driver of multicellular patterns is oscillations in single-cell signaling networks, but it is unknown what features single cells naturally modulate in these oscillations to change global patterns. An ideal system for addressing this challenge exists in the social amoeba, Dictyostelium discoideum. Dictyostelium uses travelling waves of cyclic AMP as a chemoattractant between cells to drive aggregation into a multicellular state when starving. These waves originate within single cells that release cyclic AMP to the environment, and the single-cell signaling network phenomena that drive the creation of these waves are well-characterized. Using new experimental data in conjunction with an existing phenomenological model, I explore what parameters single cells can modulate to control the properties of these signaling oscillations and the patterns they coordinate.

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Workshop / Seminar Mon, 22 Jul 2019 14:33:39 -0400 2019-08-08T11:30:00-04:00 2019-08-08T12:30:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
Electrochemical Reshaping of Living Tissues: Non-Invasive Surgical Modalities for Reshaping Cartilage and Cornea (August 8, 2019 4:00pm) https://events.umich.edu/event/64479 64479-16372908@events.umich.edu Event Begins: Thursday, August 8, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Michael Hill (Occidental College)

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Other Thu, 08 Aug 2019 18:15:24 -0400 2019-08-08T16:00:00-04:00 2019-08-08T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
CSIEUM - Workshop: Big Data in Pharma - Brainstorming a new 1-credit class (August 30, 2019 12:00pm) https://events.umich.edu/event/65519 65519-16607704@events.umich.edu Event Begins: Friday, August 30, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Marc Scanio (Abbvie)

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Other Fri, 30 Aug 2019 18:15:31 -0400 2019-08-30T12:00:00-04:00 2019-08-30T13:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Pre-Health Student Orientation (A-L) (September 3, 2019 6:00pm) https://events.umich.edu/event/64017 64017-16065442@events.umich.edu Event Begins: Tuesday, September 3, 2019 6:00pm
Location: Chemistry Dow Lab
Organized By: University Career Center

A session for all incoming and transferring pre-health students. Gather tips for successful preparation for medical school and other health profession programs. Learn about resources and services available to you at the University of Michigan. Due to room capacity, the same session will be repeated from 7:30 PM to 8:30 PM. Please make every effort to attend the appropriate session according to your last name's initial; but do feel free to choose the other one if otherwise unable to attend. PLAN TO ARRIVE BY 5:30 PM TO CHECK IN. BRING UM STUDENT ID. The Pre-Health Orientation is sponsored by the UM University Career Center and the Newnan Advising Center.

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Presentation Tue, 20 Aug 2019 12:00:39 -0400 2019-09-03T18:00:00-04:00 2019-09-03T19:00:00-04:00 Chemistry Dow Lab University Career Center Presentation Chemistry Dow Lab
Pre-Health Student Orientation (M-Z) (September 3, 2019 7:30pm) https://events.umich.edu/event/64018 64018-16065443@events.umich.edu Event Begins: Tuesday, September 3, 2019 7:30pm
Location: Chemistry Dow Lab
Organized By: University Career Center

A session for all incoming and transferring pre-health students. Gather tips for successful preparation for medical school and other health profession programs. Learn about resources and services available to you at the University of Michigan. Due to room capacity, the same session will also be offered from 6:00 PM to 7:00 PM. Please make every effort to attend the appropriate session according to your last name's initial; but do feel free to choose the other one if otherwise unable to attend. PLAN TO ARRIVE BY 7:00 PM TO CHECK IN. BRING UM STUDENT ID. The Pre-Health Student Orientation is sponsored by the UM University Career Center and the Newnan Advising Center.

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Presentation Tue, 20 Aug 2019 11:59:41 -0400 2019-09-03T19:30:00-04:00 2019-09-03T20:30:00-04:00 Chemistry Dow Lab University Career Center Presentation Chemistry Dow Lab
Increasing Molecular Coverage in Complex Biological & Environmental Samples Using Ion Mobility-Mass Spectrometry (September 5, 2019 4:00pm) https://events.umich.edu/event/64170 64170-16179703@events.umich.edu Event Begins: Thursday, September 5, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


Mass spectrometry (MS)-based technologies are playing a growing role in the analysis of complex samples. Despite significant advances in MS technology, currently it is difficult to obtain measurements of both high throughput and high sensitivity for samples with great dynamic ranges such as biofluids and plant extracts. This problem ultimately results in the inability to effectively account for variation among sample conditions and/or biodiversity leading to inconsequential findings for samples which have great variation. To address this challenge, we have coupled an ion mobility separation (IMS) with MS to afford greatly improved measurement throughput, sensitivity, robustness, and quantitative capabilities for rapid analysis of complex samples. The benefits we have observed in omic studies of biological and environmental samples with IMS-MS will be summarized in this presentation.





Erin Baker (NC State)

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Other Thu, 05 Sep 2019 18:15:31 -0400 2019-09-05T16:00:00-04:00 2019-09-05T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Biophysics Talk Title: TBD (September 6, 2019 12:00pm) https://events.umich.edu/event/64280 64280-16274491@events.umich.edu Event Begins: Friday, September 6, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstracts: TBD

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Workshop / Seminar Wed, 10 Jul 2019 11:26:22 -0400 2019-09-06T12:00:00-04:00 2019-09-06T13:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
From fluctuations to function: The role of dynamics in the mechanism and regulation of translation (September 10, 2019 4:00pm) https://events.umich.edu/event/63255 63255-15603733@events.umich.edu Event Begins: Tuesday, September 10, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Over the past two decades, stunning breakthroughs in the field of structural biology have continued to produce groundbreaking high-resolution structures of large, multi-component biomolecular machines. Comparative analyses of these static structures reveals the remarkable conformational flexibility of these machines and hints at the significant structural rearrangements that evidently accompany their functional cycles. Unfortunately, the experimental observation and characterization of these conformational dynamics is severely impeded by the size and complexity of biomolecular machines, severely limiting our understanding of the contributions that dynamics make to their functions. Using a combination of single-molecule biophysical-, structural-, and biochemical approaches, my research group aims to overcome these challenges and elucidate the precise roles that the conformational dynamics of biomolecular machines play in driving and controlling their functions. My seminar presentation will primarily focus on our studies of the mechanism and regulation of messenger RNA translation into protein by the ribosome, an essential step in gene expression. Specifically, I will discuss how thermally driven fluctuations of the ribosome and other essential translation components contribute to the mechanism and regulation of translation. Because the ribosome is the target of over half of all currently prescribed antibiotics and because of the growing list of human diseases to which deregulation of translation has been causally linked, our findings hold great promise for informing the development of next-generation antibiotics and small-molecule therapeutic agents that function by modulating the conformational dynamics of the translation machinery. Building on what we have learned from these studies, I will close my presentation by describing recent technological advances that are allowing us to investigate biomolecular dynamics which play important roles in biological mechanisms, but that have thus far remained difficult or impossible to investigate.




Ruben Gonzalez (Columbia University)

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Other Tue, 10 Sep 2019 18:15:37 -0400 2019-09-10T16:00:00-04:00 2019-09-10T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Sundaes on Tuesday (September 10, 2019 6:30pm) https://events.umich.edu/event/65533 65533-16611708@events.umich.edu Event Begins: Tuesday, September 10, 2019 6:30pm
Location: Chemistry Dow Lab
Organized By: Women in Science and Engineering (WISE) Program

WISE invites incoming freshman considering STEM majors to an ice cream extravaganza. Meet people who share your passion, learn about the resources on campus for STEM students, and make some delicious sundaes. Vegan options available!

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Social / Informal Gathering Fri, 30 Aug 2019 09:05:12 -0400 2019-09-10T18:30:00-04:00 2019-09-10T20:00:00-04:00 Chemistry Dow Lab Women in Science and Engineering (WISE) Program Social / Informal Gathering Ice cream sundae
Pushing the Limits: Mass Spectrometry of Arctic Atmospheric Chemistry (September 12, 2019 4:00pm) https://events.umich.edu/event/64128 64128-16165588@events.umich.edu Event Begins: Thursday, September 12, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Kerri Pratt (University of Michigan)

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Other Thu, 12 Sep 2019 18:15:35 -0400 2019-09-12T16:00:00-04:00 2019-09-12T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Boron Cluster Building Blocks and Synthetic Reagents (September 17, 2019 4:00pm) https://events.umich.edu/event/65046 65046-16509306@events.umich.edu Event Begins: Tuesday, September 17, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry



TBD




Alexander Spokoyny (UCLA)

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Other Tue, 17 Sep 2019 18:15:51 -0400 2019-09-17T16:00:00-04:00 2019-09-17T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Unconventional techniques of imaging and microscopy for bio-medical applications. (September 19, 2019 4:00pm) https://events.umich.edu/event/62913 62913-15494564@events.umich.edu Event Begins: Thursday, September 19, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


Over the last few years a significant effort has been directed towards unconventional imaging techniques, such as microscopy without lenses as it can overcome some of the drawbacks associated with tradition optical microscopy, that rely on objective lenses, which results in a trade-off between the field of view and the resolution. Thus lens-less microscopy allows imaging and analysis over a wide area, enabling high throughput measurements, in addition to being cost-effective and portable. In this type of microscopy, the images are computationally reconstructed from in-line holograms, which result from the interference between the scattered optical wave from the sample and the directly transmitted wave. Here, I will present about lens-free on-chip microscopy designs, image reconstruction and its utility towards a wide range of applications related to sizing of nanoparticles, nanoparticle-aggregation, bio-sensing of pathogens and rare cancer cells, characterization of polymer degradation, material properties and rheology.











Aniruddha Ray

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Other Thu, 19 Sep 2019 18:15:48 -0400 2019-09-19T16:00:00-04:00 2019-09-19T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Biophysics Talk Title: "Emerging methods in solution NMR and applications to illuminate blind spots in human biology” (September 20, 2019 12:00pm) https://events.umich.edu/event/64267 64267-16274479@events.umich.edu Event Begins: Friday, September 20, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: TBD

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Workshop / Seminar Wed, 04 Sep 2019 14:42:29 -0400 2019-09-20T12:00:00-04:00 2019-09-20T13:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
CSIEUM - Seminar TBD (September 20, 2019 4:00pm) https://events.umich.edu/event/64957 64957-16495250@events.umich.edu Event Begins: Friday, September 20, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

ChemEd
Darryl Boyd

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Other Fri, 20 Sep 2019 18:15:47 -0400 2019-09-20T16:00:00-04:00 2019-09-20T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Dr. Kevin Wood Tenure Talk (September 20, 2019 4:00pm) https://events.umich.edu/event/67138 67138-16805204@events.umich.edu Event Begins: Friday, September 20, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: TBD

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Workshop / Seminar Fri, 13 Sep 2019 12:28:49 -0400 2019-09-20T16:00:00-04:00 2019-09-20T17:30:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
Gateway NMR Meeting (September 21, 2019 8:00am) https://events.umich.edu/event/64651 64651-16404987@events.umich.edu Event Begins: Saturday, September 21, 2019 8:00am
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Registration: https://sites.google.com/umich.edu/gatewaynmr2019/home

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Meeting Fri, 26 Jul 2019 15:01:32 -0400 2019-09-21T08:00:00-04:00 2019-09-21T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Meeting Chemistry Dow Lab
Gateway NMR Meeting (September 22, 2019 8:00am) https://events.umich.edu/event/64651 64651-16404988@events.umich.edu Event Begins: Sunday, September 22, 2019 8:00am
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Registration: https://sites.google.com/umich.edu/gatewaynmr2019/home

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Meeting Fri, 26 Jul 2019 15:01:32 -0400 2019-09-22T08:00:00-04:00 2019-09-22T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Meeting Chemistry Dow Lab
Advancing The Original Cope Rearrangement: Fundamental studies and applications in complex molecule synthesis (September 24, 2019 4:00pm) https://events.umich.edu/event/63771 63771-15873581@events.umich.edu Event Begins: Tuesday, September 24, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The original Cope rearrangement is an underutilized transformation in modern organic synthesis. Recognizing its potential, the Grenning lab seeks to transform this age old reaction into a versatile platform for complex molecule synthesis. Presented will be synthetic strategy, methodology, and applications in synthesis whereby this reaction plays a central role.








Alex Grenning (University of Florida)

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Other Tue, 24 Sep 2019 18:15:45 -0400 2019-09-24T16:00:00-04:00 2019-09-24T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Biophysics Talk Title: "Mapping the Ligand Binding Landscape" (September 27, 2019 12:00pm) https://events.umich.edu/event/64270 64270-16274480@events.umich.edu Event Begins: Friday, September 27, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: TBD

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Workshop / Seminar Wed, 04 Sep 2019 14:43:16 -0400 2019-09-27T12:00:00-04:00 2019-09-27T13:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
Synthesis and Reactivity of a Terminal Co Oxo Complex (October 1, 2019 4:00pm) https://events.umich.edu/event/63512 63512-15767677@events.umich.edu Event Begins: Tuesday, October 1, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Transition metal oxo complexes, particularly those of later transition metals, have been cited as important intermediates in processes such as C-H hydroxylation and oxygen evolution. In general, however, these species are highly reactive and difficult to isolate and study. In this talk I will present our laboratories efforts at isolating and studying late transition metal oxo complexes. We have found that use of pseudo-tetrahedral geometries enables the isolation of an unusual terminal Co-oxo complex. The reactivity of this species towards C-H activation is markedly different than that observed for the majority of other systems and provides experimental evidence for a new mechanistic scenario dubbed "asynchronous" CPET. Finally, the possible relevance of related Co and Ni complexes in this system towards O-O bond formation will be discussed.
John Anderson (University of Chicago)

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Other Tue, 01 Oct 2019 18:15:55 -0400 2019-10-01T16:00:00-04:00 2019-10-01T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Nonadiabatic and Quantum Dynamics in Materials (October 3, 2019 4:00pm) https://events.umich.edu/event/63379 63379-15663386@events.umich.edu Event Begins: Thursday, October 3, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Dynamics of excited states plays a determining role in many materials such as solar cells, photocatalysts, or photo-actuated molecular switches. Electron-hole recombination, interfacial charge transfer, nonradiative excitation energy relaxation, photoinduced nuclear reorganization, and bond breaking - all require accounting for nonadiabatic (NA) effects. Nuclear tunneling and zero-point energies constitute quantum nuclear effects that may non-trivially affect the electron-nuclear dynamics. Understanding details of nonadiabatic and quantum dynamics (NA/QD) at the atomistic level requires advanced tools and methodologies. Often, one also needs to address the computational limitations due to systems’ sizes and processes’ time scales, what makes modeling NA/QD in realistic materials a challenging problem.
Over the past few years, my group has been addressing various methodological problems in NA/QD to enable computationally affordable yet reasonably accurate modeling of excited states dynamics in extended atomistic systems. In this presentation, I will overview several approaches we have developed in this regard and will illustrate their utility in modeling charge transfer dynamics in organic and inorganic solar-harvesting systems. The developments in three key areas will be highlighted: a) modeling NA/QD in extended systems via simplified semiclassical and fragmentation approaches as well as via innovative software that leverage linear-scaling electronic structure methods; b) modeling slow NA/QD via the machine-learning-inspired quasi-stochastic Hamiltonian approach and via the enhanced sampling scheme; c) accounting for quantum nuclear effects via the entangled trajectories Hamiltonian dynamics (ETHD) method. Along the way, I will touch on other important methodological questions such as the role of phase correction, decoherence, and the effect of electronic structure choice. Last but not least, I will highlight chemical insights we have gained from the NA/QD modeling in all-inorganic perovskites, quantum dots, and materials’ heterojunctions.






Alexey Akimov (University of Buffalo)

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Other Thu, 03 Oct 2019 18:15:51 -0400 2019-10-03T16:00:00-04:00 2019-10-03T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Biophysics Talk Title: TBD (October 4, 2019 12:00pm) https://events.umich.edu/event/64281 64281-16274492@events.umich.edu Event Begins: Friday, October 4, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstracts: TBD

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Workshop / Seminar Wed, 10 Jul 2019 11:27:51 -0400 2019-10-04T12:00:00-04:00 2019-10-04T13:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
CSIEUM - Seminar: Hijacking Physiological Oxygen Sensing by Small Molecule Therapeutics (October 4, 2019 12:00pm) https://events.umich.edu/event/65520 65520-16607705@events.umich.edu Event Begins: Friday, October 4, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Mike Rabinowitz (Akebia Therapeutics)

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Other Fri, 04 Oct 2019 18:16:01 -0400 2019-10-04T12:00:00-04:00 2019-10-04T13:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Revealing the chemistry in quantum chemistry: from diatomics to proton coupled electron transfer in enzymes (October 10, 2019 4:00pm) https://events.umich.edu/event/65047 65047-16509307@events.umich.edu Event Begins: Thursday, October 10, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

With quantum chemistry nowadays most physical properties of molecules can be easily and (often) accurately calculated—for example, DFT calculations of molecular structure, reaction mechanisms, and reaction energetics have become routine complements to organic chemistry. However, the techniques behind these calculations afford no easy way of "making sense" of the computed quantities, like orbitals and wave functions. Additionally, many central empirical concepts of chemistry, including concepts as basic as partial charges, bond orders, or even covalent bonds themselves, have no consensus physical definition.

We here argue that, once we properly define what is an "atomic orbital" in a molecule, quantities representing most other empirical concepts can be straight-forwardly derived from simple physical arguments, and then easily calculated. In this sense, we show how our Intrinsic Atomic Orbital (IAO) technique gives rise to partial charges and bond orders, and to bond orbitals, which represent the electron pairs of Lewis structures (σ- and π-bonds). Even curly-arrow reaction mechanisms can be readily derived!

Based on selected examples of both us and others, we how IAOs allow the analysis of bonding in novel and exotic chemical species, and how the method played a key role in understanding metal-catalyzed reaction mechanisms.
Gerald Knizia (Penn State)

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Other Thu, 10 Oct 2019 18:15:45 -0400 2019-10-10T16:00:00-04:00 2019-10-10T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Biophysics Talk Title: TBD (October 11, 2019 12:00pm) https://events.umich.edu/event/64272 64272-16274482@events.umich.edu Event Begins: Friday, October 11, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: TBD

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Workshop / Seminar Wed, 10 Jul 2019 09:38:39 -0400 2019-10-11T12:00:00-04:00 2019-10-11T13:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
CSIEUM -Seminar TBD (October 11, 2019 12:00pm) https://events.umich.edu/event/65048 65048-16509308@events.umich.edu Event Begins: Friday, October 11, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry
















Jack Barbera

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Other Mon, 09 Sep 2019 12:15:32 -0400 2019-10-11T12:00:00-04:00 2019-10-11T13:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Radical Initiation in the Radical SAM Superfamily (October 14, 2019 4:00pm) https://events.umich.edu/event/63729 63729-15835122@events.umich.edu Event Begins: Monday, October 14, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Radical SAM enzymes utilize a [4Fe-4S] cluster and S-adenosyl-L-methionine (SAM) to initiate diverse radical-based reactions throughout all kingdoms of life. Despite the limited sequence similarity and vastly divergent reactions catalyzed, the radical SAM enzymes appear to employ a common mechanism for initiation of radical chemistry, in which a reduced [4Fe-4S]+ cluster provides the electron needed for the reductive cleavage of SAM. The amino and carboxylate groups of SAM bind to the unique iron of the catalytic [4Fe-4S] cluster, placing the sulfonium of SAM in close proximity to the cluster. Surprising recent results have shown that the initial enzymatic cleavage of SAM generates an organometallic intermediate prior to liberation of 5’-dAdo•, which initiates radical chemistry on substrate. This organometallic intermediate, denoted , has a 5’-deoxyadenosyl moiety directly bound to the unique iron of the [4Fe-4S] cluster via the 5’-C, giving a structure that is directly analogous to Co-(5’-C) bond of the organometallic cofactor adenosylcobalamin. Our observation that this intermediate  is formed throughout the superfamily suggests that this is a key intermediate in initiating radical SAM reactions, and further indicates that organometallic chemistry is much more broadly relevant in biology than previously thought. We have also discovered novel photochemistry in radical SAM enzymes, wherein photoinduced electron transfer generates SAM-derived radicals, providing new insights into fundamental radical initiation chemistry.








Joan Broderick (Montana State University)

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Other Mon, 14 Oct 2019 18:15:41 -0400 2019-10-14T16:00:00-04:00 2019-10-14T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
TBA (October 15, 2019 12:00pm) https://events.umich.edu/event/67184 67184-16807427@events.umich.edu Event Begins: Tuesday, October 15, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Bradley Carrow (Princeton University)

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Other Thu, 19 Sep 2019 06:15:57 -0400 2019-10-15T12:00:00-04:00 2019-10-15T13:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Synthesis and Biological Studies of GPI Anchors and GPI-Anchored Proteins (October 16, 2019 12:00pm) https://events.umich.edu/event/65049 65049-16509309@events.umich.edu Event Begins: Wednesday, October 16, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Glycosylphosphatidylinositol (GPI) attachment to the protein C-terminus is one of the most common and important posttranslational modifications, and many surface proteins are anchored to the cell membrane via GPIs to play an important role in various biological and pathological events. To explore these events, it is necessary to obtain GPIs and GPI-anchored proteins in homogeneous and structurally well-defined forms, which represents a great challenge. Our research program aims at establishing proper methods to access natural GPIs, GPI-linked peptides/glycopeptides/proteins, and related derivatives and applying them to the study of GPI biology. Accordingly, a series of new chemical and chemoenzymatic strategies have been developed for GPI and GPI conjugate synthesis, and the synthetic molecules have been used to investigate relevant biological problems, such as GPI-cell membrane interactions, GPI-bacterial toxin interactions, and GPI-anchored proteomics analysis.










Zhongwu Guo (University of Florida)

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Other Wed, 16 Oct 2019 18:15:54 -0400 2019-10-16T12:00:00-04:00 2019-10-16T13:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Membrane Interactions and Amyloid Formation of α-Synuclein (October 17, 2019 4:00pm) https://events.umich.edu/event/64839 64839-16460976@events.umich.edu Event Begins: Thursday, October 17, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Synuclein is most well-known for its involvement in the etiology of Parkinson’s disease where α-synuclein amyloid fibrils are found in Lewy bodies, a histopathological hallmark. Membrane association of α-synuclein is associated with its biological function and implicated in pathogenesis. Upon membrane association, α-synuclein adopts an α-helical structure, whereas in solution, the protein is disordered. In a disease state, β-sheet rich, amyloid fibrils of aggregated α-synuclein accumulate in the cytosol. In this work, we aim to understand how amyloid formation is influenced by lipids and in turn, how the protein aggregation process may lead to deleterious α-synuclein interactions with membranes. We are especially interested in the ability of α-synuclein to sense and generate membrane curvature, which could have both functional and dysfunctional consequences. Building upon the fundamental understanding of α-synuclein–lipid interactions, we are developing Raman microspectroscopy to study protein conformational dynamics and aggregation in cells. This powerful approach reports on protein secondary structural changes, allowing us to identify whether the protein has adopted a β-sheet rich form, indicative of amyloid structure, as a function of its spatial location. In this talk, I will present our latest results on (1) membrane fluidity and curvature sensing by α-synuclein, (2) Raman spectroscopic characterization of α-synuclein amyloid formation, and (3) cellular studies of α-synuclein. Through our work, we are developing a chemical understanding in how specific biomolecular interactions and cellular environments modulate α-synuclein structure and aggregation propensity.
Jennifer Lee (NIH)

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Other Thu, 17 Oct 2019 18:15:50 -0400 2019-10-17T16:00:00-04:00 2019-10-17T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Biophysics Talk Title: TBD (October 18, 2019 12:00pm) https://events.umich.edu/event/64273 64273-16274483@events.umich.edu Event Begins: Friday, October 18, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: TBD

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Workshop / Seminar Wed, 10 Jul 2019 09:39:01 -0400 2019-10-18T12:00:00-04:00 2019-10-18T13:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
CALCIUM - Seminar TBD (October 18, 2019 4:00pm) https://events.umich.edu/event/65521 65521-16607706@events.umich.edu Event Begins: Friday, October 18, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Kate Crawford Biberdorf (TSMU)

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Other Fri, 18 Oct 2019 18:15:57 -0400 2019-10-18T16:00:00-04:00 2019-10-18T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
SUB-MICRON X-RAY FLUORESCENCE IMAGING OF BIOLOGICAL SAMPLES AT 2-ID-E AT THE ADVANCED PHOTON SOURCE (October 18, 2019 4:00pm) https://events.umich.edu/event/67951 67951-16971138@events.umich.edu Event Begins: Friday, October 18, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Oleg Antipova (APS)

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Other Fri, 18 Oct 2019 18:15:56 -0400 2019-10-18T16:00:00-04:00 2019-10-18T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Energy Conversion and Storage: Novel Materials and Operando Methods (October 21, 2019 4:00pm) https://events.umich.edu/event/63991 63991-16059321@events.umich.edu Event Begins: Monday, October 21, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

This presentation will deal with the development of new materials and operando methods for energy conversion and storage with emphasis on fuel cells and battery materials and technologies. The presentation will begin with a brief overview of the methods employed. Particular emphasis will be placed on the use of X-ray diffraction (XRD), X-ray absorption spectroscopy (XAS) X-ray microscopy and tomography and transmission electron microscopy (TEM) under active potential control. The utility of these methods will be illustrated by selected examples including electrocatalysts for the oxygen reduction reaction (ORR), hydrogen oxidation reaction (HOR) and spectroscopic studies of Li/S batteries and Li metal deposition and dendritic growth. The presentation will conclude with an assessment of future directions.
Hector Abruña (Cornell University)

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Other Mon, 21 Oct 2019 18:15:47 -0400 2019-10-21T16:00:00-04:00 2019-10-21T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Development of metal-oxide clusters as charge-carriers for nonaqueous redox-flow batteries (October 23, 2019 4:00pm) https://events.umich.edu/event/64523 64523-16382900@events.umich.edu Event Begins: Wednesday, October 23, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Effective integration of renewable energy from intermittent sources (i.e. solar and wind) requires the development of efficient energy storage systems which can function in tandem with the electrical grid. Non-aqueous redox-flow batteries have emerged as promising systems for large-capacity, reversible energy storage capable of meeting the variable demands of the electrical grid. The use of non-aqueous solvents increases the energy density of these systems, however there are few electrolytes with sufficient solubility and electrochemical stability to function in organic media. In this work, we investigate the potential for Lindqvist polyoxovanadate-alkoxide (POV-alkoxide) clusters to serve as both the anolyte and catholyte for symmetric, non-aqueous redox-flow batteries. POV-alkoxide clusters display numerous, highly reversible redox events, and demonstrate significant solubility and electrochemical stability in organic solvents. These bulky compounds also demonstrate the ability to mitigate species crossover and membrane fouling, thereby improving the energy efficiency and lifetime of flow battery cells. The application of POV-alkoxides as electrolytes in organic media demonstrates that the remarkable redox properties of multimetallic clusters can be harnessed for non-aqueous energy storage applications, and represents an important new direction for the generation of high performance redox-flow batteries.








Ellen Matson (University of Rochester)

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Other Wed, 23 Oct 2019 18:15:49 -0400 2019-10-23T16:00:00-04:00 2019-10-23T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Measuring Students' Understandings of Multiple Representations in Chemistry (October 24, 2019 4:00pm) https://events.umich.edu/event/65050 65050-16509310@events.umich.edu Event Begins: Thursday, October 24, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Learning chemistry requires students to become fluent in the symbolic language of chemistry. Developing expertise, however, requires that students move beyond manipulating symbols to create explanations using particulate models of matter for observations in the laboratory. Failure to accurately interpret and connect these multiple representations of matter is one source of students’ misconceptions. Our research group designs measurement tools to advance our understanding of how students understand and interpret representations for a variety of core concepts. Creating such measures presents multiple challenges with regard to establishing the precision and accuracy of the data. Insights regarding the underlying assumptions and appropriateness of commonly used psychometrics will be examined. Findings regarding students’ reasoning and misconceptions will be presented with examples drawn from general chemistry, organic chemistry, physical chemistry, and biochemistry courses.













Stacey Lowery Bretz (Miami University)

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Other Thu, 24 Oct 2019 18:15:47 -0400 2019-10-24T16:00:00-04:00 2019-10-24T17:15:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Biophysics Student Seminar (October 25, 2019 12:00pm) https://events.umich.edu/event/68668 68668-17130536@events.umich.edu Event Begins: Friday, October 25, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Shiyuan Wang - Yang Lab
Talk title: Understanding the Mitotic Oscillations with a Droplet-based System: How Does ATP Level Affect Oscillation Characteristics?

Ryan Hayes - Brooks Lab
Talk Title: Towards Protein Design with Rigorous Alchemical Calculation of
Folding Free Energies

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Workshop / Seminar Mon, 21 Oct 2019 15:42:14 -0400 2019-10-25T12:00:00-04:00 2019-10-25T13:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
ACS Lecture -Undergraduate (October 28, 2019 4:00pm) https://events.umich.edu/event/65967 65967-16678370@events.umich.edu Event Begins: Monday, October 28, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry
















Aurora Pribram-Jones (UC Merced)

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Other Mon, 28 Oct 2019 18:15:40 -0400 2019-10-28T16:00:00-04:00 2019-10-28T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Leveraging Electrophilicity and Polarizability in Catalysts for Challenging Coupling Reactions (October 30, 2019 4:00pm) https://events.umich.edu/event/67457 67457-16857831@events.umich.edu Event Begins: Wednesday, October 30, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

A general approach by our group for the development of new catalytic synthetic methods that occur with higher efficiency and selectivity, use simpler reagents, and proceed with lower energy demand involves new ancillary ligand design coupled with fundamental studies of how metal-ligand bonding dictates catalytic reactivity. In this context, the presentation will focus on our recent efforts to discover new phosphorus- and sulfur-based ligands and associated metal catalysts that manifest special properties from seemingly "weak" interactions, for instance dispersion. In one case, low-coordinate Pd complexes possessing polarizable diamondoid substituents are shown to enable a new transmetalation mechanism under exceptionally mild conditions, facilitate the first ever characterization and reactivity studies of monoligated Pd(0) – the true active catalyst in modern cross-coupling reactions, and enable direct visible light-induced bond weakening. Studies of oxidative dehydrogenative coupling reactions will also showcase evidence for a distinct C−H bond activation mechanism that we describe as electrophilic CMD or "eCMD", which has characteristics distinct from established pathways for C−H functionalization. Transition state analyses suggest this reaction pathway could be a general class of C−H activation that to date has been convoluted with the classic concerted metalation-deprotonation (CMD) model, and selection rules have been identified for predicting what catalyst structures manifest either CMD or eCMD, each of which occurs with characteristic substrate preferences and selectivity.








Bradley Carrow (Princeton University)

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Other Wed, 30 Oct 2019 18:15:13 -0400 2019-10-30T16:00:00-04:00 2019-10-30T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Biophysics Talk Title: TBD (November 1, 2019 12:00pm) https://events.umich.edu/event/64274 64274-16274484@events.umich.edu Event Begins: Friday, November 1, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: TBD

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Workshop / Seminar Wed, 10 Jul 2019 09:39:20 -0400 2019-11-01T12:00:00-04:00 2019-11-01T13:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
CALCIUM - Panel: Industry to Academia (November 1, 2019 12:00pm) https://events.umich.edu/event/67850 67850-16960491@events.umich.edu Event Begins: Friday, November 1, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

ChemEd

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Other Fri, 01 Nov 2019 18:15:21 -0400 2019-11-01T12:00:00-04:00 2019-11-01T13:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Ayyalusamy Ramamoorthy's Robert W. Parry Collegiate Professorship in Chemistry and Biophysics Lecture & Reception (November 7, 2019 4:00pm) https://events.umich.edu/event/67851 67851-16960492@events.umich.edu Event Begins: Thursday, November 7, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Physical

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Other Thu, 07 Nov 2019 18:15:22 -0500 2019-11-07T16:00:00-05:00 2019-11-07T18:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
What if we aren't alone? Human reactions to the possibility of extraterrestrial life (November 13, 2019 7:00pm) https://events.umich.edu/event/69014 69014-17213806@events.umich.edu Event Begins: Wednesday, November 13, 2019 7:00pm
Location: Chemistry Dow Lab
Organized By: Department of Astronomy

"What if we aren't alone? Human reactions to the possibility of extraterrestrial life"

Following this talk, Dr. Michael Meyer (U-M Astronomy) will lead an interdisciplinary conversation on the topic of life in the Universe with Dr. Varnum, Dr. David Baker (U-M Philosophy) and Dr. Edwin Bergin (U-M Astronomy).

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Lecture / Discussion Wed, 06 Nov 2019 12:21:54 -0500 2019-11-13T19:00:00-05:00 2019-11-13T20:30:00-05:00 Chemistry Dow Lab Department of Astronomy Lecture / Discussion What if we aren't alone?
Biophysics Talk Title: TBD (November 15, 2019 12:00pm) https://events.umich.edu/event/64282 64282-16274493@events.umich.edu Event Begins: Friday, November 15, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstracts: TBD

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Workshop / Seminar Wed, 10 Jul 2019 11:29:18 -0400 2019-11-15T12:00:00-05:00 2019-11-15T13:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
CALCIUM- Discussion: Entrepreneurism (November 15, 2019 12:00pm) https://events.umich.edu/event/65522 65522-16607707@events.umich.edu Event Begins: Friday, November 15, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Margaret McCammon (MEDC)

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Other Fri, 15 Nov 2019 18:15:42 -0500 2019-11-15T12:00:00-05:00 2019-11-15T13:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
MilliporeSigma Seminar (November 19, 2019 4:00pm) https://events.umich.edu/event/69006 69006-17213799@events.umich.edu Event Begins: Tuesday, November 19, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Organic

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Other Tue, 19 Nov 2019 18:15:30 -0500 2019-11-19T16:00:00-05:00 2019-11-19T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Commercial Route Development of DaurismoTM, a SMO Inhibitor (November 20, 2019 10:30am) https://events.umich.edu/event/69336 69336-17310069@events.umich.edu Event Begins: Wednesday, November 20, 2019 10:30am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Joe Tucker (Pfizer)

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Other Wed, 20 Nov 2019 18:15:47 -0500 2019-11-20T10:30:00-05:00 2019-11-20T12:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Biophysics Talk Title: TBD (November 22, 2019 12:00pm) https://events.umich.edu/event/64275 64275-16274485@events.umich.edu Event Begins: Friday, November 22, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: TBD

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Workshop / Seminar Wed, 10 Jul 2019 09:39:35 -0400 2019-11-22T12:00:00-05:00 2019-11-22T13:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
Third Year Inorganic Student Seminars (December 6, 2019 4:00pm) https://events.umich.edu/event/69191 69191-17263094@events.umich.edu Event Begins: Friday, December 6, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Inorganic

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Other Fri, 06 Dec 2019 18:15:42 -0500 2019-12-06T16:00:00-05:00 2019-12-06T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Analytical 3rd year seminar (December 11, 2019 4:00pm) https://events.umich.edu/event/69337 69337-17310070@events.umich.edu Event Begins: Wednesday, December 11, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Analytical

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Other Wed, 11 Dec 2019 18:15:42 -0500 2019-12-11T16:00:00-05:00 2019-12-11T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Materials Third Year Student Seminars (December 12, 2019 12:00pm) https://events.umich.edu/event/69051 69051-17222091@events.umich.edu Event Begins: Thursday, December 12, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

This presentation will focus on the covalent bonding of small organic molecules (alkanes, viologens) on silicon surfaces for advanced photovoltaic and photoelectrochemical applications. The data explores the premise that the type of surface bonding will influence the resultant electronic properties of the interface. Results from X-ray photoelectron spectroscopy, Fourier-transform infrared spectroscopy, microwave conductivity, and electrochemical measurements of as prepared silicon electrode surfaces will be detailed and discussed. Overall, these findings suggest two points. First, Si-C bonds more directly eliminate and prevent surface defects in possible device applications. Second, covalently attached viologens are possible platforms for studying electron transfer between Si and fixed redox acceptors.
Taylor Bramlett, Michael Bellas, Giacomo Di Mauro, Takunda Chazovachii, Wenhao Shao, Brianna Barbu, Taylor Soucy, Robert Vasquez

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Other Thu, 12 Dec 2019 18:15:31 -0500 2019-12-12T12:00:00-05:00 2019-12-12T16:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Third Year Inorganic Student Seminars (December 13, 2019 4:00pm) https://events.umich.edu/event/69192 69192-17263095@events.umich.edu Event Begins: Friday, December 13, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Inorganic

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Other Fri, 13 Dec 2019 18:15:37 -0500 2019-12-13T16:00:00-05:00 2019-12-13T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Chemical Biology Approaches for Interrogating the Contributions of Altered Circadian Rhythms and Macrophages to Cancer Aggression (January 21, 2020 4:00pm) https://events.umich.edu/event/71647 71647-17853447@events.umich.edu Event Begins: Tuesday, January 21, 2020 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Research in the Farkas group involves the development and use of molecular tools in order to study, image, and treat cancer subtypes. Significant advances have been made in understanding and treating cancer, however, there remain many unknowns, especially in the arena of how and why particular diseases become aggressive and metastasize. We are specifically interested in the roles that macrophages, and separately, altered circadian rhythms, play in cancer. Our work has focused on their investigation via generation and use of platforms that enable detection and tracking in biologically-relevant models, followed by perturbation and study of those systems with small molecules. Macrophages have the ability to interconvert between immune stimulating- and suppressing-subtypes, and are recruited and contribute to oncogenic microenvironments. Because many breast tumors generate macrophage chemoattractants, we are taking advantage of this characteristic and developing cell-based imaging and drug delivery agents via chemical modification of the cells' surfaces. We are also engineering macrophages to possess reporters in order to discern phenotypes, and probing phenotypic conversion via small molecules. My research program is also involved in determining the significance of circadian rhythms in breast cancer. Epidemiological evidence has shown that alteration of circadian rhythms is correlated with worse patient prognosis and drug resistance. We are assessing circadian rhythms in cell culture models of cancer, and using small molecules to modulate these rhythms in an effort to understand the link between altered circadian rhythms and disease. Our work is intended to not only shed new light on contributors to cancer, but also provide new targets and drugs for treatments.







Michelle Farkas (University of Massachusetts Amherst)

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Other Tue, 21 Jan 2020 18:16:01 -0500 2020-01-21T16:00:00-05:00 2020-01-21T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
TBD (January 23, 2020 4:00pm) https://events.umich.edu/event/71648 71648-17853448@events.umich.edu Event Begins: Thursday, January 23, 2020 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry
















Jennifer Heemstra (Emory University)

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Other Thu, 23 Jan 2020 18:15:53 -0500 2020-01-23T16:00:00-05:00 2020-01-23T17:15:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Discovery and characterization of novel small molecules as in vivo tool compounds for addition and bone disorders (January 28, 2020 11:45am) https://events.umich.edu/event/69685 69685-17378574@events.umich.edu Event Begins: Tuesday, January 28, 2020 11:45am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Despite the promise for the use of chemical tools for investigating biological process and disease, many small molecule probes for most pathways/targets were unknown or unavailable until recently. Work in the Hopkins Laboratory centers around the synthesis and optimization of novel chemical tool compounds aimed at understanding biological processes and tackling unmet medical needs. This talk will cover two projects in my lab: 1. Synthesis and optimization of novel phosphodiesterase inhibitors as possible therapies for cocaine use disorders, and 2. The synthesis, optimization and biological characterization of a series activin receptor-like kinase 2 (ALK2) inhibitors for the treatment of rare and neglected diseases.









Corey Hopkins (University of Nebraska)

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Other Tue, 28 Jan 2020 18:15:48 -0500 2020-01-28T11:45:00-05:00 2020-01-28T13:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Investigating Protein Degradation at the Interface of Chemistry and Biology (January 28, 2020 11:45am) https://events.umich.edu/event/70908 70908-17735213@events.umich.edu Event Begins: Tuesday, January 28, 2020 11:45am
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Faculty Candidate
Host: U. Jakob

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Workshop / Seminar Fri, 24 Jan 2020 13:28:03 -0500 2020-01-28T11:45:00-05:00 2020-01-28T12:45:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials on blue background
Global Insights into Brain Diversity, Development, and Lineage at Single-Cell Resolution (January 30, 2020 11:45am) https://events.umich.edu/event/70909 70909-17735214@events.umich.edu Event Begins: Thursday, January 30, 2020 11:45am
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Faculty Candidate
Host: C. Duan

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Workshop / Seminar Fri, 24 Jan 2020 13:26:23 -0500 2020-01-30T11:45:00-05:00 2020-01-30T12:45:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials and yellow microscope on blue background
Physical Chemistry Third Year Seminars (January 30, 2020 4:00pm) https://events.umich.edu/event/69301 69301-17301822@events.umich.edu Event Begins: Thursday, January 30, 2020 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Ralph Crisci(Hydration at polymer/protein solution interfaces) , Kristina Lenn(Modeling Exciton Transport in Light-Harvesting Systems) , Ryan Burdick(Entangled two-photon effects in organic molecules induced by frequency entangled photons)

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Other Thu, 30 Jan 2020 18:15:53 -0500 2020-01-30T16:00:00-05:00 2020-01-30T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
MCDB Remembering the past and rewiring the future: A protein-based inheritance paradigm (February 4, 2020 11:45am) https://events.umich.edu/event/70910 70910-17735215@events.umich.edu Event Begins: Tuesday, February 4, 2020 11:45am
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Faculty Candidate
Host: R. Stockbridge

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Workshop / Seminar Fri, 24 Jan 2020 13:31:02 -0500 2020-02-04T11:45:00-05:00 2020-02-04T12:45:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials and yellow microscope on blue background
Chem Bio 3rd Year Seminar (February 4, 2020 4:00pm) https://events.umich.edu/event/68411 68411-17080043@events.umich.edu Event Begins: Tuesday, February 4, 2020 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Chembio

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Other Tue, 04 Feb 2020 18:16:03 -0500 2020-02-04T16:00:00-05:00 2020-02-04T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
"Universal Alkene Functionalization as an Aspirational Driver" (February 5, 2020 4:00pm) https://events.umich.edu/event/70445 70445-17596550@events.umich.edu Event Begins: Wednesday, February 5, 2020 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


Vicinal (1,2-disubstituted) functional group motifs are
ubiquitous in structurally complex small molecules that are of
academic and industrial importance, including many widely used
pharmaceutical agents. Many such functional group combinations,
however, remain exceptionally challenging to synthesize. The goal of
research in the Engle lab is to develop a general catalytic platform
for alkene and alkyne difunctionalization to introduce a diverse array
of functional groups at each of the two carbon atoms in a programmable
fashion. Our central hypothesis is that is that Lewis basic directing
groups can be used to: (1) control the regioselectivity of Heck- and
Wacker-type alkene addition, (2) stabilize the resultant alkylmetal
intermediate to allow to allow efficient downstream trapping, and (3)
enhance selectivity for three-component coupling over competitive
two-component coupling. This concept has been used to expand the
synthetic toolkit to include new retrosynthetic disconnections,
including “homo-Michael” addition and β,γ-vicinal
dicarbofunctionalization of alkenyl carbonyl compounds.









Keary Engle (Scripps Research Institute)

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Other Wed, 05 Feb 2020 18:16:05 -0500 2020-02-05T16:00:00-05:00 2020-02-05T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Temporal Regulation of the Blood-Brain Barrier (February 6, 2020 11:45am) https://events.umich.edu/event/70911 70911-17735216@events.umich.edu Event Begins: Thursday, February 6, 2020 11:45am
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Faculty Candidate
Host: G. Csankovszki & Wilinski

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Workshop / Seminar Fri, 24 Jan 2020 13:28:56 -0500 2020-02-06T11:45:00-05:00 2020-02-06T12:45:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials and yellow microscope on blue background
Photolytic properties of cobalamins: a theoretical perspective (February 6, 2020 4:00pm) https://events.umich.edu/event/63868 63868-15955821@events.umich.edu Event Begins: Thursday, February 6, 2020 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry
















Pawel Kozlowski (University of Louisville)

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Other Thu, 06 Feb 2020 18:16:10 -0500 2020-02-06T16:00:00-05:00 2020-02-06T17:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
CALCIUM- Exploring Alcohol Production and the Alcohol Industry with Ann Arbor Distilling Co. (February 7, 2020 12:00pm) https://events.umich.edu/event/71173 71173-17785574@events.umich.edu Event Begins: Friday, February 7, 2020 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

ChemEd

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Other Fri, 07 Feb 2020 18:15:55 -0500 2020-02-07T12:00:00-05:00 2020-02-07T13:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
“Rieske Mono- and Di- Oxygenases – A Hat-Trick of Chemical Strategies for Oxygen Activation" (February 11, 2020 4:00pm) https://events.umich.edu/event/65210 65210-16549472@events.umich.edu Event Begins: Tuesday, February 11, 2020 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Rieske mono- and di- oxygenases (ROs) use a nonheme mononuclear Fe and a 12 Å-distant 2Fe2S Rieske cluster to catalyze an enormous range of oxidative reactions, which exceeds even those of cyt P450 and methane monooxygenase. Like the latter two oxygenases, the transfer of two electrons from NADH to the RO metal centers is required for reaction. Oxygen activation and insertion into substrates occurs at the mononuclear Fe(II) center, but one electron transfer from the reduced Rieske cluster is required at some point during the reaction cycle to observe product formation. The involvement of 2 electrons and oxygen at the mononuclear Fe suggests that at least three different types of reactive oxygen intermediates can be envisioned: (1) stepwise electron transfer with intermediate formation of a reactive Fe(III)-superoxo species, (2) two electron transfer to oxygen to form an Fe(III)-peroxo species, or (3) O-O bond cleavage of the peroxo-intermediate to form a high-valent reactive species. Ongoing biochemical and chemical biomimetic studies suggest that all three reactive oxygen species may be represented within the RO family despite nearly identical metal environments. Indeed, when presented with different substrates, a single RO enzyme may adopt two or more of these strategies depending on the relative ease of substrate oxidation versus the rate of electron transfer between metal centers










John Lipscomb (University of Minnesota)

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Other Tue, 11 Feb 2020 18:16:10 -0500 2020-02-11T16:00:00-05:00 2020-02-11T17:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
John Lipscomb (February 11, 2020 4:00pm) https://events.umich.edu/event/65166 65166-16545447@events.umich.edu Event Begins: Tuesday, February 11, 2020 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




John Lipscomb (University of Minnesota)

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Other Tue, 13 Aug 2019 06:15:21 -0400 2020-02-11T16:00:00-05:00 2020-02-11T17:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Visualizing Bacterial Physiology at High Resolution using Single-Molecule Tracking and Lattice-Light Sheet Microscopy (February 13, 2020 4:00pm) https://events.umich.edu/event/65267 65267-16559497@events.umich.edu Event Begins: Thursday, February 13, 2020 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our lab develops new imaging approaches for visualizing bacterial physiology in relevant contexts: We use live-cell single-molecule localization microscopy and lattice-light sheet microscopy to access 3D spatial and temporal information with high resolution. At molecular and cellular length scales, our research focuses on understanding how Gram-negative bacterial pathogens inject effector proteins into the cytosol of eukaryotic host cells using the Type 3 Secretion System (T3SS) – a 7 MDa multi-protein complex that spans two, and sometimes three cellular membranes. Type 3 secretion is a major virulence mechanism used by prominent bacterial pathogens that results in more than 1 million human deaths each year. At cellular and super-cellular length scales, our research focuses on visualizing the behaviors of individual bacteria inside tissue-like microbial communities, called biofilms. As a major component of bacterial biomass on earth, biofilms have substantial impacts on the biogeochemistry of our planet and on the biochemistry of higher living organisms.
In the first part of my talk, I will describe how single-molecule localization and tracking microscopy in different genetic backgrounds provides a path towards investigating the molecular mechanism(s) of type 3 secretion in living cells. Through computational aberration correction and numerical modeling, we determine the 3D subcellular localization and diffusive states of individual, fluorescently labeled T3SS proteins. Our results to date indicate that T3SS proteins pre-assemble into freely diffusing cytosolic complexes prior to binding to the membrane-spanning multi-protein complex. Determining to what extent cytosolic proteins assemble with each other in living cells provides key insights into the dynamic regulatory network that controls type 3 secretion.
In the second part of my talk, I will describe how lattice light-sheet microscopy enables non-invasive 3D imaging of microbial biofilms at single-cell resolution. Analyzing the resulting 3D images using a combination of computer vision and machine learning approaches enables multi-cell tracking of cell motions, cell morphologies, and cellular gene expression over time. Our goal now is to apply these new imaging and image analysis approaches to understand the emerging functional capabilities of bacterial biofilms in terms of the behavioral phenotypes of individual cells. Such knowledge can help inform new strategies for controlling biofilm growth and harness the metabolic potential of the microbial world in biotechnological applications.















Andreas Gahlmann (University of Virginia)

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Other Thu, 13 Feb 2020 18:16:13 -0500 2020-02-13T16:00:00-05:00 2020-02-13T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Physical Chemistry Third Year Seminars (February 14, 2020 4:00pm) https://events.umich.edu/event/69302 69302-17301823@events.umich.edu Event Begins: Friday, February 14, 2020 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Federica Ricci(Coherent Energy and Charge Transfer Processes Probed in Solution and in the Solid State with Time-Re) , Tieyi Lu(Probing the Interfacial Peptides/Proteins by using Sum Frequency Generation Spectroscopy) , Rong Duan(Exploring vibrational polaritonic systems using multidimensional spectroscopy)

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Other Fri, 14 Feb 2020 18:15:54 -0500 2020-02-14T16:00:00-05:00 2020-02-14T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Atmospheric chemistry of volatile organic compounds in the limit as nitric oxide concentrations decline to pre-industrial levels. (February 17, 2020 4:00pm) https://events.umich.edu/event/64491 64491-16374909@events.umich.edu Event Begins: Monday, February 17, 2020 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


As a result of controls on NOx emissions from cars, trucks, and electricity production, NOx levels (sum on NO and NO2) have decreased rapidly across North America over the past decades. The reductions in NO alter the photochemical pathways in the oxidation of numerous chemicals emitted from the biosphere and from anthropogenic activities. The gas phase chemistry in the low NO regime has received significantly less attention from atmospheric chemists. Here, I describe new analytical methods to probe the low NOx chemistry in the field and in the laboratory. New chemical pathways are identified illustrating that great care must be taken in extrapolating of existing photochemical models to the low NOx atmosphere.















Paul Wennberg (California Institute of Technology)

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Other Mon, 17 Feb 2020 18:15:52 -0500 2020-02-17T16:00:00-05:00 2020-02-17T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Fibrillization and Liquid-Liquid Phase Separation of the Tau Peptide (February 20, 2020 4:00pm) https://events.umich.edu/event/67852 67852-16960493@events.umich.edu Event Begins: Thursday, February 20, 2020 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry
















Joan-Emma Shea (University of California - Santa Barbara)

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Other Thu, 20 Feb 2020 18:16:06 -0500 2020-02-20T16:00:00-05:00 2020-02-20T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
CALCIUM: Panel: Teaching at Faith-Based Schools (February 21, 2020 12:00pm) https://events.umich.edu/event/72032 72032-17916361@events.umich.edu Event Begins: Friday, February 21, 2020 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Tom Kunzelman(Spring Arbor) , Kendra Evans(UD-Mercy) , Stephen Leonard(Indiana Wesleyan) , Jolia Leonard(Indiana Wesleyan)

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Other Fri, 21 Feb 2020 18:15:59 -0500 2020-02-21T12:00:00-05:00 2020-02-21T13:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Using Systems Thinking Concepts in General Chemistry to Combat Compartmentalized Knowledge Acquisition (February 25, 2020 4:00pm) https://events.umich.edu/event/70975 70975-17762324@events.umich.edu Event Begins: Tuesday, February 25, 2020 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

A common observation about student learning in introductory university chemistry courses is that they have a tendency to compartmentalize their understanding of chemistry concepts. To some extent, the curricular content choices of the course may exacerbate this tendency by using a reductionist approach to presenting topics. While this manner of organizing content is likely important in helping emphasize foundational concepts of chemistry, the extent to which students transfer their knowledge to new situations may be affected by this content presentation strategy. Bringing the idea of systems thinking to the general chemistry course represents a way to maintain the careful instructional tactics of foundational topics while at the same time putting them into larger, societal contexts that assist students in using their chemistry knowledge in new situations. A key question that directs the implementation of the systems thinking pedagogical strategy for teaching is, "Are we considering the right boundary for this chemistry, or do we need to connect it to larger contexts and systems?" Examples of how planetary boundaries and systems thinking can be employed in general chemistry to expand how students view the applicability of their newly gained chemistry knowledge will be described and the results of these efforts over the past several years in chemistry classes at Iowa State will be evaluated in this presentation.














Thomas Holme (Iowa State)

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Other Tue, 25 Feb 2020 18:15:53 -0500 2020-02-25T16:00:00-05:00 2020-02-25T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Rethinking biomimicry in synthetic non-heme iron complexes (February 26, 2020 4:00pm) https://events.umich.edu/event/69886 69886-17482924@events.umich.edu Event Begins: Wednesday, February 26, 2020 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


Synthetic iron-based catalysts that functionally model iron dependent oxygenases are rare. Considering the large number of synthetic iron complexes, why is this? We are taking a close look at this question and, in the process, have come up with some design principles that are guiding our work towards developing synthetic iron-based catalysts that use O2 as the oxidant. This work represents a major effort in our group towards sustainable chemistry by using earth abundant metals and oxidants that are non-toxic.









David Lacy (University of Buffalo)

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Other Wed, 26 Feb 2020 18:16:07 -0500 2020-02-26T16:00:00-05:00 2020-02-26T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Physical Chemistry Third Year Seminars (February 27, 2020 4:00pm) https://events.umich.edu/event/69303 69303-17301824@events.umich.edu Event Begins: Thursday, February 27, 2020 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Elvin Salerno(Applications of lanthanide luminescence in thermometry and molecular magnetism) , Hanjie Jiang(Towards a cost-effective wave function theory for charge transfer energies and electronic couplings)

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Other Thu, 27 Feb 2020 18:16:08 -0500 2020-02-27T16:00:00-05:00 2020-02-27T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Comprehensive Understanding of Material Characteristics of Perfluoroalkyl Compounds Studied by Vibrational Spectroscopy (March 4, 2020 4:00pm) https://events.umich.edu/event/72033 72033-17916362@events.umich.edu Event Begins: Wednesday, March 4, 2020 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Organofluorine compounds represented by perfluoroalkyl (Rf) compounds involving polytetrafluoroethylene (PTFE) attract keen interest for various practical chemistry fields such as material science and pharmaceutical science. Research of organofluorine compounds, however, has long been oriented to organic synthesis, and physicochemical background is still weak to fully understand the material property on the primary chemical structure. Recently, the Stratified Dipole-Arrays (SDA) theory [Chem. Rec. 2017, 17, 903.] has been published, which comprehensively explains various Rf compound-specific properties for both macroscopic and microscopic properties. On this theory, quantitative analysis of the molecular aggregation and orientation is being developed by using infrared and Raman spectroscopy. Multiple-angle incidence resolution spectrometry (MAIRS) coupled with FT-IR readily reveals the perfectly perpendicular orientation of a compound having an Rf chain with a length of (CF2)7 or longer in the two-dimensional molecular aggregate, i.e., a thin film. On the SDA theory, each molecular aggregate should be consisted of one of the right- or left-handed helical Rf chains. This means that the molecular domain of an Rf compound should exhibit Raman optical activity (ROA) even if the compound has no chiral center. In fact, our measurements of ROA on a single crystal of a Rf compound apparent ROA signal [J. Phys. Chem. 2019, 123, 3985.]. In this manner, vibrational spectroscopy works as a powerful tool to reveal the fine chemical structure of molecular aggregation of Rf compounds. For the full understanding, however, a conventional concept for hydrocarbons must be changed, since the relative mass of fluorine to carbon is overturned to the case of hydrogen to carbon. In the talk, fundamental details of vibrational spectroscopy on the SDA theory are presented in a comprehensive manner.









Takeshi Hasegawa (Kyoto University)

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Other Wed, 04 Mar 2020 18:15:51 -0500 2020-03-04T16:00:00-05:00 2020-03-04T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
RNP Granules in Health and Disease (March 9, 2020 4:00pm) https://events.umich.edu/event/65593 65593-16621787@events.umich.edu Event Begins: Monday, March 9, 2020 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Eukaryotic cells contain multiple assemblies of RNA and protein referred to as RNP granules, or RNP condensates. In the cytosol, ubiquitous RNP granules include stress granules, which form when translation initation is limited, and P-bodies, which are constitutive RNP granules containing mRNAs and the RNA decay machinery. Both stress granules and P-bodies contain complex proteomes and transcriptomes and their assembly/disassembly are regulated by diverse RNP remodeling complexes.
Focusing on stress granules, we have provided evidence that stress granule, and presumably other RNP condensate, assembly occurs in part through intermolecular RNA-RNA interactions. However, based on in vitro studies, we demonstrate that RNA condensation should be expected to be a thermodynamically favored process in cells. This argues cells must contain mechanisms to limit RNA driven condensation. We have demonstrated that abundant RNA helicase reduces RNA recruitment to RNA condensates in vitro and in cells, as well as limiting stress granule formation. This defines a new function for abundant RNA helicases to limit thermodynamically favored intermolecular RNA-RNA interactions in cells as “RNA decondenases”, thereby allowing proper RNP function.










Roy Parker (HHMI/Univ of Colorado Boulder)

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Other Mon, 02 Mar 2020 12:15:46 -0500 2020-03-09T16:00:00-04:00 2020-03-09T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Questioning Assumptions in Lewis Acid Catalysis (March 10, 2020 11:45am) https://events.umich.edu/event/69375 69375-17312377@events.umich.edu Event Begins: Tuesday, March 10, 2020 11:45am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The interactions between Lewis acids and carbonyls have played a significant role in the construction of important molecules. While a great deal of insight has been gained regarding classical stoichiometric regimes, more discoveries continue to be made about the complexities of these interactions between carbonyls and Lewis acids in catalytic systems. In particular, the new reactivity observed in Lewis acid-catalyzed carbonyl-olefin metathesis demonstrates that a comprehensive understanding of the interactions between these classical Lewis pairs remains incomplete. It is our hypothesis that the application of in situ techniques will provide key insights into reactivity initiated by the interactions of Lewis pairs that are as yet unexplored. Synthetic, spectroscopic, kinetic, and computational techniques will be presented which facilitate characterization of both the ground and transition state behavior of Lewis acids and carbonyl compounds. These data will be used to demonstrate the complex interplay of Lewis acid catalyst, substrate, and product under synthetically relevant conditions. Overall, these rigorous mechanistic studies catalogue the factors critical to concise reaction design, and more specifically, detail the mechanistic features of carbonyl-olefin metathesis.




James Devery (Loyola University Chicago)

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Other Tue, 10 Mar 2020 18:15:54 -0400 2020-03-10T11:45:00-04:00 2020-03-10T13:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Designing Functional Sites in Porous Materials for Energy Storage and Conversion (March 11, 2020 4:00pm) https://events.umich.edu/event/72004 72004-17914112@events.umich.edu Event Begins: Wednesday, March 11, 2020 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Despite their high theoretical specific energy of 2,600 Wh kg-1, the commercialization of Li-S devices is hindered by irreversible capacity loss from the dissolution of polysulfide intermediates in the electrolyte solution. We report novel strategies to design reactive sites for polysulfide adsorption in metal-organic frameworks (MOFs) to improve capacity retention and ionic conductivity. Incorporation of redox-active moieties in the framework further enable fast charge and discharge capabilities. Identifying structure-property-function relationships in tunable molecular platforms offer new methods to advance electrochemical storage technologies. In addition, we will present new strategies to probe the electrode-electrolyte interfaces in electrocatalysis using advanced electrochemical techniques such as in-situ vibrational spectroscopy and electrochemical impedance spectroscopy. The ubiquity of surfactants and carbon supports in catalysis warrants a closer examination on their influence on the electrode-electrolyte interface during carbon dioxide reduction. New insights on the impact of molecular additives and carbonaceous materials on product formation and Faradaic efficiency in electrocatalytic carbon conversion will be discussed.






Sara Thoi (Johns Hopkins University)

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Other Mon, 09 Mar 2020 12:15:49 -0400 2020-03-11T16:00:00-04:00 2020-03-11T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Reasoning in organic chemistry – dealing with the iceberg (March 12, 2020 3:00pm) https://events.umich.edu/event/72453 72453-18009346@events.umich.edu Event Begins: Thursday, March 12, 2020 3:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Organic chemistry is a heavily information and structure-laden discipline, and relies on making sense of the implicit deep level. A huge amount of problem-solving and reasoning in organic chemistry requires drawing and/or interpreting structural representations of chemical substances. The ability to interpret a given representation and go beyond the explicit image is thus one of the major skills to successfully perform in chemistry. However less is known about what information students are actually processing when they need to draw connections between a chemical representation and the chemical meaning that it is meant to convey. How do they connect perceptional “surface-level” attributes of a representation with “deep-level” implicit attributes, what are productive resources in students reasoning? To fill this gap, we performed several qualitative studies with undergraduate organic chemistry students to characterize students’ mechanistic reasoning and to derive instructional support.






Nicole Graulich (The Institute of Chemistry Education Justus-Liebig-Universitat Gieben)

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Other Fri, 06 Mar 2020 06:15:54 -0500 2020-03-12T15:00:00-04:00 2020-03-12T16:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Coarse Graining Electrons and Computational Optimization of Electric Fields for Better Catalysis Design (March 12, 2020 4:00pm) https://events.umich.edu/event/64042 64042-16101236@events.umich.edu Event Begins: Thursday, March 12, 2020 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Prediction of electrostatic properties for molecules is of vital importance in numerous research disciplines. In biochemistry, the electrostatic potential is a dominant factor determining the preference for functional states in biomolecules such as ligand-binding or protein-protein interactions. In material science, the function of nanoporous crystals such as zeolites and metal-organic frameworks for gas storage and separation applications rely on their ability to absorb polar molecules. In electrochemistry, the function of electrochemical cells relies on the diffusion of ions and the double-layer formation at the electrode surface. Computational modeling of these systems thereby requires an accurate description of the electrostatic interaction between the different components of these complex system. Although the ubiquitous role that long-ranged electric fields play in catalysis has been recognized, it is seldom used as a primary design parameter in the discovery of new catalytic materials. I will present results on how electric fields have been used to computationally optimize biocatalytic performance of a synthetic enzyme, and how they could be used as a unifying descriptor for catalytic design across a range of homogeneous and heterogeneous catalysts. While focusing on electrostatic environmental effects may open new routes toward the rational optimization of efficient catalysts, much more predictive capacity is required of theoretical methods to have a transformative impact in their computational design – and thus experimental relevance – when using electric field alignments in the reactive centres of complex catalytic systems. I will discuss some of these methodological advances from accurate many-body force fields under non-reactive approximations in classical molecular dynamics, to reactive force fields to describe chemical reactions where charge flow is an essential process.

Teresa Head-Gordon (University of California, Berkeley)

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Other Tue, 03 Mar 2020 12:15:54 -0500 2020-03-12T16:00:00-04:00 2020-03-12T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
----All In-Person Events Canceled Until Further Notice--- (March 13, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337268@events.umich.edu Event Begins: Friday, March 13, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-03-13T07:00:00-04:00 2020-03-13T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
CALCIUM: Faculty’s Network of Influence: How Peer Interactions Inform Faculty Teaching Decisions (March 13, 2020 12:00pm) https://events.umich.edu/event/72034 72034-17916363@events.umich.edu Event Begins: Friday, March 13, 2020 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


















Marilyne Stains (U Virginia)

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Other Mon, 09 Mar 2020 12:15:49 -0400 2020-03-13T12:00:00-04:00 2020-03-13T13:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
----All In-Person Events Canceled Until Further Notice--- (March 14, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337269@events.umich.edu Event Begins: Saturday, March 14, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-03-14T07:00:00-04:00 2020-03-14T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
----All In-Person Events Canceled Until Further Notice--- (March 15, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337270@events.umich.edu Event Begins: Sunday, March 15, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-03-15T07:00:00-04:00 2020-03-15T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
----All In-Person Events Canceled Until Further Notice--- (March 16, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337271@events.umich.edu Event Begins: Monday, March 16, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-03-16T07:00:00-04:00 2020-03-16T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
Delivering Innovative Medicines: Small Changes Can Have a Large Effect (March 16, 2020 2:30pm) https://events.umich.edu/event/72098 72098-17939961@events.umich.edu Event Begins: Monday, March 16, 2020 2:30pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry














Wendy Young (Genentech)

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Other Mon, 24 Feb 2020 12:15:50 -0500 2020-03-16T14:30:00-04:00 2020-03-16T16:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Chaperoning Evolution (March 16, 2020 4:00pm) https://events.umich.edu/event/71649 71649-17853449@events.umich.edu Event Begins: Monday, March 16, 2020 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Protein homeostasis (proteostasis) networks, along with fundamental biophysics, govern protein evolution. Acquisition of adaptive amino acid mutations during evolution is often kinetically or thermodynamically destabilizing to proteins. Chaperones from the proteostasis machinery can rescue these destabilizing mutations when they occur in endogenous client proteins. By combining new methods for chemical perturbation of proteostasis machinery with evolutionary biology techniques, we discovered that this phenomenon has profound impact on the ability of RNA viruses to adapt to environmental and immune system pressures. In particular, we show that influenza hijacks host chaperones to address folding defects that viral proteins acquire as they evolve to escape the host’s innate and adaptive immune systems. The dependence of viruses on their host’s protein folding network makes them highly vulnerable to immune suppression when folding assistance is limited. Host chaperones, therefore, play a central role in facilitating viral adaptation at the host–pathogen interface, a finding with potentially far-reaching implications for viral host-switching and drug/antibody resistance development. Currently, we are investigating how these types of phenomena impact the evolution of other disease-relevant genes, including oncogenes.


Matthew Shoulders (MIT)

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Other Mon, 09 Mar 2020 06:15:49 -0400 2020-03-16T16:00:00-04:00 2020-03-16T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
----All In-Person Events Canceled Until Further Notice--- (March 17, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337272@events.umich.edu Event Begins: Tuesday, March 17, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-03-17T07:00:00-04:00 2020-03-17T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
TBA (March 17, 2020 11:30am) https://events.umich.edu/event/72179 72179-17950783@events.umich.edu Event Begins: Tuesday, March 17, 2020 11:30am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Wendy Young (Genentech)

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Other Mon, 24 Feb 2020 12:15:51 -0500 2020-03-17T11:30:00-04:00 2020-03-17T13:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
A Designer's Toolkit for Constructing Complex Nanoparticle Libraries (March 17, 2020 4:00pm) https://events.umich.edu/event/71650 71650-17853450@events.umich.edu Event Begins: Tuesday, March 17, 2020 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


Multi-component nanoparticles offer unique opportunities to combine different properties in a single construct, enabling both multi-functionality and the emergence of new synergistic functions. Synthesizing such multi-component nanoparticles requires simultaneous control over size, shape, composition, and structure, as well as interfaces and spatial arrangements. We have been developing two complementary strategies for synthesizing multi-component nanoparticles. The first approach involves heterogeneous seeded growth, where interfaces and asymmetry are introduced by sequentially growing new nanoparticles off of the surfaces of existing nanoparticles. Complex hybrid nanoparticles of a growing number of materials, configurations, and morphologies can now be synthesized. The second approach involves sequential partial cation exchange reactions, where interfaces and asymmetry are introduced by compositional modifications that are made within an existing nanoparticle. A growing library of complex heterostructured metal sulfide nanoparticles can now be rationally designed and then readily synthesized.











Raymond Schaak (The Pennsylvania State University)

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Other Wed, 11 Mar 2020 12:15:58 -0400 2020-03-17T16:00:00-04:00 2020-03-17T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
----All In-Person Events Canceled Until Further Notice--- (March 18, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337273@events.umich.edu Event Begins: Wednesday, March 18, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-03-18T07:00:00-04:00 2020-03-18T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
Water, so common, so mysterious (March 18, 2020 4:00pm) https://events.umich.edu/event/64993 64993-16501292@events.umich.edu Event Begins: Wednesday, March 18, 2020 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Water
So Common, So Mysterious

Richard N. Zare
Department of Chemistry, Stanford University
Stanford, California 94305 USA
zare@stanford.edu
















Richard Zare (Stanford University)

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Other Wed, 11 Mar 2020 06:15:54 -0400 2020-03-18T16:00:00-04:00 2020-03-18T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
----All In-Person Events Canceled Until Further Notice--- (March 19, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337274@events.umich.edu Event Begins: Thursday, March 19, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-03-19T07:00:00-04:00 2020-03-19T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
The Wonderful World of Scanning Electrochemical Microscopy (SECM) (March 19, 2020 4:00pm) https://events.umich.edu/event/64849 64849-16462988@events.umich.edu Event Begins: Thursday, March 19, 2020 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

In its simplest form, SECM is a scanning probe technique in which a small- scale electrode is scanned across an immersed substrate while recording the current response. This response is dependent on both the surface topography and the electrochemical activity of the substrate. Consequently, using an array of operational modes, a wide variety of substrates and experimental systems can be characterized. The strength of SECM lies in its ability to quantify material flux from a surface with a high spatial and temporal resolution. It has been used in a variety of applications fields.
We will first describe the fundamentals of SECM, including the required instrumentation and the principles of the most frequently used operational modes. Following this basic understanding of SECM principles, we then move towards a comprehensive summary of the critical parameters for any SECM experiment. More specifically, we will discuss in detail redox mediators, probes, and solvent systems that are used in SECM experiments. Finally, we will discuss our recent applications of SECM with an emphasis on our work in the last five years related to material characterisation, corrosion and batteries.








Janine Mauzeroll (McGill University)

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Other Wed, 11 Mar 2020 12:15:58 -0400 2020-03-19T16:00:00-04:00 2020-03-19T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
----All In-Person Events Canceled Until Further Notice--- (March 20, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337275@events.umich.edu Event Begins: Friday, March 20, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-03-20T07:00:00-04:00 2020-03-20T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
Discussion: Growing Up in Science (March 20, 2020 12:00pm) https://events.umich.edu/event/72035 72035-17916364@events.umich.edu Event Begins: Friday, March 20, 2020 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry










Weiji Ma (NYU)

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Other Mon, 09 Mar 2020 12:15:50 -0400 2020-03-20T12:00:00-04:00 2020-03-20T13:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
----All In-Person Events Canceled Until Further Notice--- (March 21, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337276@events.umich.edu Event Begins: Saturday, March 21, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-03-21T07:00:00-04:00 2020-03-21T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
----All In-Person Events Canceled Until Further Notice--- (March 22, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337277@events.umich.edu Event Begins: Sunday, March 22, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-03-22T07:00:00-04:00 2020-03-22T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
----All In-Person Events Canceled Until Further Notice--- (March 23, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337278@events.umich.edu Event Begins: Monday, March 23, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-03-23T07:00:00-04:00 2020-03-23T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
----All In-Person Events Canceled Until Further Notice--- (March 24, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337279@events.umich.edu Event Begins: Tuesday, March 24, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-03-24T07:00:00-04:00 2020-03-24T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
----All In-Person Events Canceled Until Further Notice--- (March 25, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337280@events.umich.edu Event Begins: Wednesday, March 25, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-03-25T07:00:00-04:00 2020-03-25T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
----All In-Person Events Canceled Until Further Notice--- (March 26, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337281@events.umich.edu Event Begins: Thursday, March 26, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-03-26T07:00:00-04:00 2020-03-26T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
Physical Chemistry Third Year Seminars (March 26, 2020 4:00pm) https://events.umich.edu/event/69304 69304-17301825@events.umich.edu Event Begins: Thursday, March 26, 2020 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




John Andre(Sum frequency generation vibrational spectroscopy studies on buried polymer interfacial structures a) , Diksha Dhawan(Best Hamiltonians for Quantum Computing)

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Other Thu, 26 Mar 2020 18:15:21 -0400 2020-03-26T16:00:00-04:00 2020-03-26T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
----All In-Person Events Canceled Until Further Notice--- (March 27, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337282@events.umich.edu Event Begins: Friday, March 27, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-03-27T07:00:00-04:00 2020-03-27T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
Biophysics- Talk Title: TBD (March 27, 2020 12:00pm) https://events.umich.edu/event/64276 64276-16274486@events.umich.edu Event Begins: Friday, March 27, 2020 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: TBD

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Workshop / Seminar Wed, 10 Jul 2019 09:39:47 -0400 2020-03-27T12:00:00-04:00 2020-03-27T13:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
Discussion: Structuring Student Interactions for more Effective & Inclusive Group Work (March 27, 2020 12:00pm) https://events.umich.edu/event/72036 72036-17916365@events.umich.edu Event Begins: Friday, March 27, 2020 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

ChemEd

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Other Fri, 27 Mar 2020 18:15:29 -0400 2020-03-27T12:00:00-04:00 2020-03-27T13:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
----All In-Person Events Canceled Until Further Notice--- (March 28, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337283@events.umich.edu Event Begins: Saturday, March 28, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-03-28T07:00:00-04:00 2020-03-28T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
----All In-Person Events Canceled Until Further Notice--- (March 29, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337284@events.umich.edu Event Begins: Sunday, March 29, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-03-29T07:00:00-04:00 2020-03-29T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
----All In-Person Events Canceled Until Further Notice--- (March 30, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337285@events.umich.edu Event Begins: Monday, March 30, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-03-30T07:00:00-04:00 2020-03-30T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
Integrating cryogenic ion chemistry and optical spectroscopy: A new tool to capture the molecular level mechanics driving bulk behavior (March 30, 2020 4:00pm) https://events.umich.edu/event/72155 72155-17948627@events.umich.edu Event Begins: Monday, March 30, 2020 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The coupling between ambient ionization sources, developed for mass spectrometric analysis of biomolecules, and cryogenic ion processing, originally designed to study interstellar chemistry, creates a new and general way to capture transient chemical species and elucidate their structures with optical spectroscopies. Advances in non-linear optics over the past decade allow single-investigator, table top lasers to access radiation from 550 cm-1 in the infrared to the vacuum ultraviolet. When spectra are acquired using predissociation of weakly bound rare gas “tags,” the resulting patterns are directly equivalent to absorption spectra of target ions at temperatures below 10 K, and quenched close to their global minimum energy geometries. Taken together, what emerges is a new and powerful structural capability that augments the traditional tools available in high resolution mass spectrometry. Currently, these methods are being exploited to monitor chemical and physical processes in assemblies with well-defined temperatures and compositions. Recent applications, ranging from the mechanisms of small molecule activation by homogeneous catalysts to the microscopic mechanics underlying the ultrafast spectral diffusion in water, emphasize the generality and utility of the methods in contemporary chemistry.





Mark Johnson (Yale University)

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Other Wed, 11 Mar 2020 12:15:59 -0400 2020-03-30T16:00:00-04:00 2020-03-30T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
----All In-Person Events Canceled Until Further Notice--- (March 31, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337286@events.umich.edu Event Begins: Tuesday, March 31, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-03-31T07:00:00-04:00 2020-03-31T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
Discovering New Chemistry in the Microbial World (March 31, 2020 4:00pm) https://events.umich.edu/event/67853 67853-16960494@events.umich.edu Event Begins: Tuesday, March 31, 2020 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Microbial natural products serve as a dominant source of pharmaceutical compounds and comprise some of our most celebrated cures. Recent studies, however, have been plagued by the frequent rediscovery of old molecules. The underlying reason is that the vast majority of natural product biosynthetic genes in a given bacterium are not significantly expressed, when cultured under standard laboratory conditions. These so-called ‘silent’ or ‘cryptic’ gene clusters represent a large reservoir of bioactive molecules and methods that access them would have a profound impact on natural products research and thereby on drug discovery. In this talk, I will present new strategies that my group has developed for activating silent biosynthetic gene clusters. Application of these approaches to diverse bacteria has unveiled not only the products of silent gene clusters, but also small molecule elicitors, which in most cases are growth-inhibitory or antibiotic in nature. These insights have led to the idea that old antibiotics may be used to find new ones. In addition, my group has been engaged in elucidating new transformations carried out by metalloenzymes during natural product biosynthesis. Recent reactions that we have discovered, along with proposed mechanisms, will be presented as well.











Mohammad Seyedsayamdost (Princeton University)

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Other Wed, 11 Mar 2020 12:15:59 -0400 2020-03-31T16:00:00-04:00 2020-03-31T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
----All In-Person Events Canceled Until Further Notice--- (April 1, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337287@events.umich.edu Event Begins: Wednesday, April 1, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-04-01T07:00:00-04:00 2020-04-01T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
----All In-Person Events Canceled Until Further Notice--- (April 2, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337288@events.umich.edu Event Begins: Thursday, April 2, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-04-02T07:00:00-04:00 2020-04-02T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
----All In-Person Events Canceled Until Further Notice--- (April 3, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337289@events.umich.edu Event Begins: Friday, April 3, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-04-03T07:00:00-04:00 2020-04-03T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
Biophysics Talk Title: TBD (April 3, 2020 12:00pm) https://events.umich.edu/event/64277 64277-16274487@events.umich.edu Event Begins: Friday, April 3, 2020 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: TBD

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Workshop / Seminar Wed, 10 Jul 2019 09:41:12 -0400 2020-04-03T12:00:00-04:00 2020-04-03T13:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
----All In-Person Events Canceled Until Further Notice--- (April 4, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337290@events.umich.edu Event Begins: Saturday, April 4, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-04-04T07:00:00-04:00 2020-04-04T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
----All In-Person Events Canceled Until Further Notice--- (April 5, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337291@events.umich.edu Event Begins: Sunday, April 5, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-04-05T07:00:00-04:00 2020-04-05T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
----All In-Person Events Canceled Until Further Notice--- (April 6, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337292@events.umich.edu Event Begins: Monday, April 6, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-04-06T07:00:00-04:00 2020-04-06T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
Telomerase Holoenzyme Assembly, Structure, and Action at Telomeres (April 6, 2020 4:00pm) https://events.umich.edu/event/63637 63637-15824834@events.umich.edu Event Begins: Monday, April 6, 2020 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


Telomerase is the eukaryotic ribonucleoprotein reverse transcriptase that protects genome stability by adding telomeric repeats to chromosome ends. Altered telomerase function is implicated in cancer, aging and other human diseases. To understand telomerase, we have defined cellular telomerase holoenzyme subunits and structures, biochemical mechanisms that underlie the reiterative synthesis of telomeric repeats, and cellular controls of telomerase action at telomeres. Our recent studies of have uncovered unanticipated layers of complexity in how telomerase RNA folds, the pathways of active enzyme assembly, and positive and negative regulation of telomerase at chromosome ends.










Kathleen Collins (UC Berkeley)

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Other Wed, 11 Mar 2020 12:15:59 -0400 2020-04-06T16:00:00-04:00 2020-04-06T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
----All In-Person Events Canceled Until Further Notice--- (April 7, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337293@events.umich.edu Event Begins: Tuesday, April 7, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-04-07T07:00:00-04:00 2020-04-07T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
Harnessing the Winstein Rearrangement: Dynamic Chemistry of Allylic Azides (April 7, 2020 11:45am) https://events.umich.edu/event/67854 67854-16960495@events.umich.edu Event Begins: Tuesday, April 7, 2020 11:45am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Chiral amines are ubiquitous motifs in organic molecules of societal value. The synthesis of certain chiral amines remains a synthetic challenge. Presented herein is an unusual approach to chiral amine synthesis that utilizes the spontaneous rearrangement of allylic azides (Winstein Rearrangement). One component of the equilibrating mixture can be selectively trapped, establishing the amine bearing stereocenter. However, accomplishing this in practice requires high levels of selectivity and the simultaneous application of numerous control elements. Approaches to enabling selectivity will be described along with synthetic applications of the reactions, including in the synthesis of heterocyclic products.










Joseph Topczewski (University of Minnesota)

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Other Wed, 11 Mar 2020 12:15:59 -0400 2020-04-07T11:45:00-04:00 2020-04-07T13:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
----All In-Person Events Canceled Until Further Notice--- (April 8, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337294@events.umich.edu Event Begins: Wednesday, April 8, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-04-08T07:00:00-04:00 2020-04-08T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
----All In-Person Events Canceled Until Further Notice--- (April 9, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337295@events.umich.edu Event Begins: Thursday, April 9, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-04-09T07:00:00-04:00 2020-04-09T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
----All In-Person Events Canceled Until Further Notice--- (April 10, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337296@events.umich.edu Event Begins: Friday, April 10, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-04-10T07:00:00-04:00 2020-04-10T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
Panel: Industry Job Applications Q/A (April 10, 2020 12:00pm) https://events.umich.edu/event/72037 72037-17916366@events.umich.edu Event Begins: Friday, April 10, 2020 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

ChemEd

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Other Fri, 10 Apr 2020 18:15:12 -0400 2020-04-10T12:00:00-04:00 2020-04-10T13:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
----All In-Person Events Canceled Until Further Notice--- (April 11, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337297@events.umich.edu Event Begins: Saturday, April 11, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-04-11T07:00:00-04:00 2020-04-11T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
----All In-Person Events Canceled Until Further Notice--- (April 12, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337298@events.umich.edu Event Begins: Sunday, April 12, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-04-12T07:00:00-04:00 2020-04-12T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
----All In-Person Events Canceled Until Further Notice--- (April 13, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337299@events.umich.edu Event Begins: Monday, April 13, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-04-13T07:00:00-04:00 2020-04-13T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
----All In-Person Events Canceled Until Further Notice--- (April 14, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337300@events.umich.edu Event Begins: Tuesday, April 14, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-04-14T07:00:00-04:00 2020-04-14T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
TBA (April 14, 2020 4:00pm) https://events.umich.edu/event/62938 62938-15520065@events.umich.edu Event Begins: Tuesday, April 14, 2020 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Robert Batey (University of Colorado at Boulder)

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Other Tue, 10 Mar 2020 12:16:02 -0400 2020-04-14T16:00:00-04:00 2020-04-14T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
----All In-Person Events Canceled Until Further Notice--- (April 15, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337301@events.umich.edu Event Begins: Wednesday, April 15, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-04-15T07:00:00-04:00 2020-04-15T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
----All In-Person Events Canceled Until Further Notice--- (April 16, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337302@events.umich.edu Event Begins: Thursday, April 16, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-04-16T07:00:00-04:00 2020-04-16T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
Pushing the boundaries of H/D exchange-mass spectrometry to analyze glycans (April 16, 2020 4:00pm) https://events.umich.edu/event/67855 67855-16960496@events.umich.edu Event Begins: Thursday, April 16, 2020 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Glycans are complex molecules with different carbohydrate subunits, linkage stereochemistries, and branching patterns; all of which play a role in their biological functions. Hydrogen / deuterium exchange–mass spectrometry (HDX-MS) has become a standard method for analyzing conformations and binding interactions of solvated proteins. Carbohydrates, model systems for glycans, are susceptible to HDX since they contain labile hydrogens, primarily in the form of hydroxyls, which can be labeled with deuterium (D) upon exposure to deuterated solvents. However, compared to backbone amides, the functional group detected in traditional HDX-MS experiments for proteins, the exchange rate of glycan hydroxyls is two to eight orders of magnitude faster, depending on solution pH. This rapid exchange rate makes it unfeasible to monitor HDX of carbohydrate hydroxyls using traditional, bottom-up HDX methods.
Herein, we describe our ongoing efforts to characterize solvated carbohydrates. We perform rapid HDX by introducing deuterating reagents (e.g. D2O) to carbohydrates during electrospray ionization (ESI). Our work illustrates that these rapid, in-ESI HDX methods characterize solvated carbohydrates rather than gas-phase structures. Furthermore, we have coupled our experimental work with molecular dynamics simulations to identify the mechanism of carbohydrate ionization during ESI. Experimentally, we have quantified how ESI source conditions alter the magnitude of HDX for carbohydrate model systems, developed an internal standard to control for daily humidity differences, and established methods to alter the HDX labeling time on the microsecond to millisecond timescale. We are now applying these in-ESI HDX methods to characterize carbohydrate isomers and non-covalent carbohydrate-protein interactions.



Elyssia Gallagher (Baylor University)

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Other Wed, 11 Mar 2020 12:16:00 -0400 2020-04-16T16:00:00-04:00 2020-04-16T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
----All In-Person Events Canceled Until Further Notice--- (April 17, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337303@events.umich.edu Event Begins: Friday, April 17, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-04-17T07:00:00-04:00 2020-04-17T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
Biophysics Talk Title: TBD (April 17, 2020 12:00pm) https://events.umich.edu/event/64278 64278-16274488@events.umich.edu Event Begins: Friday, April 17, 2020 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: TBD

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Workshop / Seminar Wed, 10 Jul 2019 09:42:41 -0400 2020-04-17T12:00:00-04:00 2020-04-17T13:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
----All In-Person Events Canceled Until Further Notice--- (April 18, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337304@events.umich.edu Event Begins: Saturday, April 18, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-04-18T07:00:00-04:00 2020-04-18T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
----All In-Person Events Canceled Until Further Notice--- (April 19, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337305@events.umich.edu Event Begins: Sunday, April 19, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-04-19T07:00:00-04:00 2020-04-19T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
----All In-Person Events Canceled Until Further Notice--- (April 20, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337306@events.umich.edu Event Begins: Monday, April 20, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-04-20T07:00:00-04:00 2020-04-20T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
Gomberg - Dinshaw Patel (April 20, 2020 4:00pm) https://events.umich.edu/event/67856 67856-16960497@events.umich.edu Event Begins: Monday, April 20, 2020 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Dinshaw Patel (Memorial Sloan Kettering Cancer Center)

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Other Wed, 11 Mar 2020 12:16:00 -0400 2020-04-20T16:00:00-04:00 2020-04-20T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
----All In-Person Events Canceled Until Further Notice--- (April 21, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337307@events.umich.edu Event Begins: Tuesday, April 21, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-04-21T07:00:00-04:00 2020-04-21T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
----All In-Person Events Canceled Until Further Notice--- (April 22, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337308@events.umich.edu Event Begins: Wednesday, April 22, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-04-22T07:00:00-04:00 2020-04-22T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
----All In-Person Events Canceled Until Further Notice--- (April 23, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337309@events.umich.edu Event Begins: Thursday, April 23, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-04-23T07:00:00-04:00 2020-04-23T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
----All In-Person Events Canceled Until Further Notice--- (April 24, 2020 7:00am) https://events.umich.edu/event/73836 73836-18337310@events.umich.edu Event Begins: Friday, April 24, 2020 7:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our events will be virtual through the fall.

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Other Wed, 05 Aug 2020 11:18:10 -0400 2020-04-24T07:00:00-04:00 2020-04-24T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other block M with word Chemistry
Clay Bennett Seminar (May 5, 2020 9:00am) https://events.umich.edu/event/73176 73176-18151410@events.umich.edu Event Begins: Tuesday, May 5, 2020 9:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Organic

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Other Thu, 30 Apr 2020 06:15:12 -0400 2020-05-05T09:00:00-04:00 2020-05-05T18:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab