Happening @ Michigan https://events.umich.edu/list/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. Research Education and Activities for Classroom Teachers (June 22, 2018 9:30am) https://events.umich.edu/event/51957 51957-12327241@events.umich.edu Event Begins: Friday, June 22, 2018 9:30am
Location: North Campus Research Complex Building 10
Organized By: American Chemical Society Polymer Division - Student Chapter

REACT is a one-day workshop for Michigan K-12 STEM teachers at the University of Michigan (Ann Arbor campus). This event provides K-12 STEM teachers free exposure to the impactful research being done at the University of Michigan through focused student talks, lab tours, and hands-on demonstrations by student organizations.

This year's REACT workshop includes research from Macromolecular Science and Engineering, Materials Science and Engineering, Environmental Sciences, Mechanical Engineering and Robotics, Electrical Engineering, Climate and Space Sciences and Engineering, Chemical Engineering, Human Genetics, and Physics.

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Workshop / Seminar Mon, 16 Apr 2018 09:25:00 -0400 2018-06-22T09:30:00-04:00 2018-06-22T17:00:00-04:00 North Campus Research Complex Building 10 American Chemical Society Polymer Division - Student Chapter Workshop / Seminar
ChE Special Seminar: Dr. (William) Joshua Kennedy (July 20, 2018 1:00pm) https://events.umich.edu/event/53080 53080-13220160@events.umich.edu Event Begins: Friday, July 20, 2018 1:00pm
Location: North Campus Research Complex Building 10
Organized By: Chemical Engineering

"Optical Detection of Process Parameters in Structural Polymer Nanocomposites Using Gold Nanorods"

ABSTRACT:
The real-time measurement of thermophysical properties in structural polymers is crucial to the optimization of processing parameters for composites manufacturing. However, robust techniques for in-situ monitoring of key parameters such as temperature, stress, strain, viscosity, and degree of cure with high sensitivity and spatial resolution are lacking. Many optically active nanoparticles, including fluorescent quantum dots and plasmonic nanostructures, change their optical signatures in response to various environmental stimuli. These materials are good candidates for embedded sensing in polymers because of their high signal-to-noise and intrinsic non-contact sensing modality. However, because spectral shifts can arise through a variety of mechanisms, a thorough understanding of the fundamental relationships between environment and optical response is needed. I will show that the thermal shape transformation of gold nanorods in a polymer matrix is governed by multiple mechanisms, and these competing mechanisms lead to different behaviors at short and long time scales. This understanding can be exploited in order to use gold nanorods as a way to simultaneously measure temperature, dielectric constant, and modulus in a structural polymer resin.

BIO:
(William) Joshua Kennedy received his Ph.D. in Physics from the University of Utah in 2011. His graduate work and early postdoctoral work at the University of Texas - Dallas was focused on the study of the optoelectronic properties of carbon nanotubes and nanotube polymer nanocomposites. During a postdoctoral fellowship at Nasa Johnson Space Center, Dr. Kennedy studied the functional response of optically active polymer nanocomposites for space applications, and he developed a new piezoelectric composite for use on the International Space Station. Dr. Kennedy now works as a Research Physicist at the Air Force Research Laboratory at Wright-Patterson Air Force Base in Dayton, OH. He is a member of the Polymer Matrix Composites Materials and Processes Research Team where he focuses on the development of multifunctional structural composite materials and embedded sensors for composite processing.

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Workshop / Seminar Wed, 18 Jul 2018 14:23:20 -0400 2018-07-20T13:00:00-04:00 2018-07-20T14:00:00-04:00 North Campus Research Complex Building 10 Chemical Engineering Workshop / Seminar
BME PhD Defense: Tuğba Topal (August 10, 2018 1:00pm) https://events.umich.edu/event/53267 53267-13330229@events.umich.edu Event Begins: Friday, August 10, 2018 1:00pm
Location: North Campus Research Complex Building 10
Organized By: Biomedical Engineering

The Effects of Mechanical Forces on Human Embryonic Stem Cell Behavior



The development of an organism from a zygote into a fully functional 3D individual is a process in which a strong coupling of morphogens and mechanical forces is coordinated with embryo shape. During development, cells communicate with each other through cell-cell junctions and with their microenvironment via mechanical cues to regulate cell fate, re-organize the extracellular matrix, and guide developmental process. Most studies on human embryonic stem cells (hESCs) focused on how external soluble factors including growth factors and small inhibitors, gene and protein expression, and signaling pathways to maintain stemness or initiate differentiation of these cells. A various array of environmental factors including the effect of geometry and mechanical properties of extracellular matrix on stem cells contributes to altering stem cell fate. Recently, increasing evidence has revealed the importance of mechanical factors in affecting migration, proliferation and stem cell differentiation in vitro.



In this dissertation, we focus on the development and application of novel bioengineering approaches to understand the effects of mechanical forces on hESC behaviors and the directed differentiation of hESCs. Specifically, by employing a microfluidic device to induce controlled and regulated forces that apply global mechanical forces to adherent hESCs, we find that uniaxial substrate stretching disrupts the pluripotency circuit and initiates the exit of transcription factors, Nanog and Oct4, from the nucleus into the cytoplasm via a nuclear export protein (CRM1) as early as 30 min after stretch application and for 2 hours on a flexible substrate coated with Matrigel, and is not reliant on exogenous soluble factors. In order to pinpoint to the receptors responsible for mechanical sensing, we employ a novel technique, acoustic tweezing cytometery (ATC), that utilizes ultrasound pulses to actuate functionalized microbubbles targeted to integrin in order to apply cyclic strain to hESCs. We find that ATC-mediated cyclic forces applied for 30 min induced immediate global responses in the colony, including increased contractile force, enhanced calcium activity, as well as decreased nuclear expression of pluripotency transcription factors Oct4 and Nanog, leading to rapid differentiation and characteristic epithelial-mesenchymal transition (EMT) events that depend on focal adhesion kinase activation and cytoskeleton tension. These results reveal a unique, rapid mechanoresponsiveness and community behavior of hESCs to integrin-targeted cyclic forces. Furthermore, we demonstrate an integrative mechanotransduction that induced neural rosette formation of hESCs via the application of ATC and induction medium. We observe upregulation of Pax6 and Sox1 in as early as 6 hours, following by neural rosettes formation in 48 hours, which is much faster compared to the typical 10-15 days needed with conventional neural rosettes formation protocols.



Together, this dissertation presents novel findings and insights regarding the effects of external mechanical forces on hESCs. Such information may help elucidate the mechanobiology of hESCs, and thus advance our knowledge of human embryogenesis, regenerative medicine, and tissue engineering.

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Presentation Tue, 31 Jul 2018 08:53:18 -0400 2018-08-10T13:00:00-04:00 2018-08-10T14:00:00-04:00 North Campus Research Complex Building 10 Biomedical Engineering Presentation BME-EVENT Placeholder
ChE Special Seminar: Marie-Paule Pileni (August 16, 2018 1:30pm) https://events.umich.edu/event/52891 52891-13107800@events.umich.edu Event Begins: Thursday, August 16, 2018 1:30pm
Location: North Campus Research Complex Building 10
Organized By: Chemical Engineering

Marie-Paule Pileni
Université Pierre et Marie Curie
Paris, France

"Nanocrystallinity, Supracrystals: Unexpected Behavior"

ABSTRACT: The nanocrystals with low size distribution self assemble in 3D superlattices called supracrystals. The crystalline structure of nanocrystals called nanocrystallinity plays a key role on these self-assemblies Heterogeneous and homogeneous growth processes of supracrystals take place inducing marked changes in their physical properties.

We describe some physical and chemical properties of nanomaterials differing by the crystalline structures called nanocrystallinity: It is demonstrated that nanocrystallinity plays a major role in the final structure when nanocrystals are subjected to oxidation processes (Kinkendall effect). Concerning the optical properties, some processes are markedly affected by the crystalline structure whereas others are negligeable.

“Clustered” and “eggs” structures are hydrophobic supracrystals are dispersed in aqueous solution with a very high stability (almost two years). Solubilization of hydrophobic supracrystal in aqueous solution is obtained with Co and Au supracrystals with appearance of tunable plasmonic metamaterials. With Au supracrystals, the optical properties revealed that the fingerprint of nanocrystal is preserved even for large crystalline aggregates demonstrating that the nanocrystal could be used as a probe for investigating the optical properties of such assemblies.

BIO: Marie-Paule Pileni is a distinguished professor at the Université Pierre et Marie Curie (UPMC). She obtained an honors degree in physical chemistry (1970) and a Ph.D (1977) at the UPMC. She was director, between 1996 and 2000, of the Struc­ture and Reactivity of Interfaces Laboratory (SRI), a Université Pierre et Marie Curie - Centre national de la recherche scientifique (CNRS) joint unit. In 2000, she created the Laboratoire des Matéri­aux Mésoscopiques et Nanométriques (LM2N) (Mesoscopic and Nanometric Materials Laboratory). Her areas of specialization are nanomaterials self assemblies, colloids, and physical chemistry.

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Lecture / Discussion Thu, 05 Jul 2018 15:50:50 -0400 2018-08-16T13:30:00-04:00 2018-08-16T14:30:00-04:00 North Campus Research Complex Building 10 Chemical Engineering Lecture / Discussion
Maternal Infant Health Improvement Plan: Southeast Michigan Town Hall Satellite Meeting (August 16, 2018 6:00pm) https://events.umich.edu/event/53268 53268-13330234@events.umich.edu Event Begins: Thursday, August 16, 2018 6:00pm
Location: North Campus Research Complex Building 10
Organized By: Michigan Medicine, OBGYN Department

The Michigan Department of Health and Human Services (MDHHS) and the Maternal Infant Strategy Group (MISG) are hosting four regional town hall meetings to collect community input on the state's 2019--- 2022 Mother Infant Health Improvement Plan.

Objectives:
1. Introduce the logic model for the 2019-2022 Mother Infant Health Improvement Plan (MIHIP).

2. Collect feedback from the community to determine priorities and barriers to successful program implementation.

3. Bridge community partners to work together to improve the health of mothers and babies

AGENDA:
6:00 pm - Welcome and Introductions, Town Hall Overview
6:20 pm - Introduction of the Mother Infant Health Improvement Plan
6:40 pm - Small Group Discussion and Reports
7:20 pm - Looking Ahead

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Other Tue, 31 Jul 2018 10:47:26 -0400 2018-08-16T18:00:00-04:00 2018-08-16T19:30:00-04:00 North Campus Research Complex Building 10 Michigan Medicine, OBGYN Department Other Town Hall Flyer
ChE Seminar Series: K. Dane Wittrup (October 11, 2018 1:30pm) https://events.umich.edu/event/56532 56532-13939989@events.umich.edu Event Begins: Thursday, October 11, 2018 1:30pm
Location: North Campus Research Complex Building 10
Organized By: Chemical Engineering

C.P. Dubbs Professor of Chemical Engineering and Biological Engineering
Associate Director, Koch Institute for Integrative Cancer Research
Massachusetts Institute of Technology

ABSTRACT

"Bioengineering of synergistic innate and adaptive immunotherapy of cancer"

Harnessing the immune system to attack cancer has started a revolution in oncology. The ability of the adaptive immune system to track such evolving pathologies has provided robust responses and cures in 10-25% of previously intractable cancers such as metastatic melanoma. The next frontier is to “raise the tail” of the survival curve in such cancers by finding synergistic combination therapies. Chemical and biological engineers have pioneered approaches that are well suited to such investigations, bringing quantitative problem-solving synthetic and analytical toolkits to bear. I’ll provide examples from my lab where cocktails of anti-tumor antibodies and cytokines have accomplished highly safe and efficacious therapies as tested in mouse models of cancer.

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Lecture / Discussion Tue, 09 Oct 2018 10:37:14 -0400 2018-10-11T13:30:00-04:00 2018-10-11T14:30:00-04:00 North Campus Research Complex Building 10 Chemical Engineering Lecture / Discussion
MilliporeSigma Lecture (October 16, 2018 10:00am) https://events.umich.edu/event/56447 56447-13905905@events.umich.edu Event Begins: Tuesday, October 16, 2018 10:00am
Location: North Campus Research Complex Building 10
Organized By: Macromolecular Science & Engineering

Molecular Understanding, Design and Development of Ultra-low Fouling Zwitterionic Materials

An important challenge in many applications, ranging from drug delivery carriers to medical devices, is the prevention of nonspecific protein adsorption on surfaces. To address this challenge, our goals are twofold. First, we strive to provide a fundamental understanding of nonfouling mechanisms at the molecular level. Second, we aim to develop biocompatible and environmentally benign ultra low fouling materials based on the molecular principles we have learned. Over the last 15 years, we have demonstrated that zwitterionic and mixed charge materials and surfaces are highly resistant to nonspecific protein adsorption, cell adhesion and bacteria adhesion/biofilm formation from complex media. Both simulation and experimental results indicate that the strong hydration of zwitterionic materials is responsible for their excellent nonfouling properties. Recent results show that zwitterionic materials do not induce immunological response in blood circulation and capsule formation upon implantation and are able to preserve protein and cell bioactivity. Zwitterionic materials have been shown to be superior to poly(ethylene glycol) (PEG)-based materials for a number of biomedical and engineering applications such as drug delivery carriers, medical devices, cell preservation/expansion media, and marine coatings.

RSVP to MacroProgram@umich.edu or call 734-763-2316 by October 12th.

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Lecture / Discussion Fri, 05 Oct 2018 13:17:00 -0400 2018-10-16T10:00:00-04:00 2018-10-16T11:00:00-04:00 North Campus Research Complex Building 10 Macromolecular Science & Engineering Lecture / Discussion
ChE Seminar Series: Greg Thurber (October 16, 2018 1:30pm) https://events.umich.edu/event/56664 56664-13960666@events.umich.edu Event Begins: Tuesday, October 16, 2018 1:30pm
Location: North Campus Research Complex Building 10
Organized By: Chemical Engineering

Assistant Professor
Department of Chemical Engineering
University of Michigan

ABSTRACT

"Molecular Engineering of Advanced Imaging Agents and Therapeutics:
Using ChE principles to aid in design"


Traditionally, drug development has proceeded in a linear fashion from optimizing target affinity, validating in cell culture, testing in animal models, and moving to the clinic. For some drugs, such as small molecules, extensive data are available to define empirical ‘rules’ to help guide development of early screening hits to avoid attrition at later stages. However, for new, more advanced therapeutics, sufficient data are not available for empirical guidance. Because of their more complex structures, many of these agents have transport limitations within the body. These include the transient kinetics of an imaging agent reaching its target and washing out of the background or a macromolecular therapeutic trying to navigate its way through the tumor microenvironment and bind a receptor, either inside or outside the cell.


Our lab uses predictive computational transport simulations to guide the design of these agents without the need for a priori data. I will outline several examples where these transport limitations give rise to counter-intuitive results. These include i) the design of antibody-drug
conjugates, where lower potency can result in higher tumor killing, ii) directed evolution of stabilized alpha helical peptides where lower cellular efficacy can more efficiently hit currently ‘undruggable’ targets in the body, and iii) use of high charge density to improve oral
absorption and targeting of a ‘disease screening pill.’ By incorporating these predictive, multiscale simulations – from the molecular level to the whole organism scale – we can use molecular engineering to help design novel therapeutics and imaging agents rather than develop them through costly trial-and-error.

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Lecture / Discussion Thu, 11 Oct 2018 15:02:24 -0400 2018-10-16T13:30:00-04:00 2018-10-16T14:30:00-04:00 North Campus Research Complex Building 10 Chemical Engineering Lecture / Discussion Greg Thurber
ChE Seminar Series: Cecilia Leal (October 25, 2018 1:30pm) https://events.umich.edu/event/56806 56806-14006009@events.umich.edu Event Begins: Thursday, October 25, 2018 1:30pm
Location: North Campus Research Complex Building 10
Organized By: Chemical Engineering

Department of Materials Science and Engineering
University of Illinois at Urbana-Champaign

ABSTRACT
"Complexity in the chemistry and physics of lipid membranes as a handle to activate the delivery of cargo to cells"

Lipid materials having nanostructures that deviate from the conventional flat bilayer arrangement such as hexagonally packed lipid tubes and bicontinuous cubic phases are ubiquitous in nature. Their role remains elusive but over the years several pathologies and organelle functions have been coupled to lipid membrane structural complexity. In this talk we will discuss lipid membrane polymorphism and how it can be exploited to generate a new class of materials for the delivery of cargo to cells. We combine a number of techniques including X-ray scattering, cryo-EM, and cell culture to demonstrate that the structure of lipid nanoparticles is a powerful handle to boost the delivery of genes to cells. The simple argument that non-bilayer phases having intertwined nanoscale channels exist to increase surface-to-volume ratio might be insufficient to completely describe the experimental findings. We will show that synthetic lipid and lipid-polymer hybrid materials are able to capture many structural and dynamic properties seen in natural systems, when local heterogeneities and self-assembly out of equilibrium is taken into account.

BIO
Cecilia Leal is an Assistant Professor of Materials Science and Engineering and is affiliated with the Frederick Seitz Materials Research Laboratory at University of Illinois at Urbana-Champaign. She received a M.S. in Industrial Chemistry from the University of Coimbra in Portugal and a PhD in Physical Chemistry from the University of Lund in Sweden. Cecilia was a Swedish Research Council postdoctoral fellow in Materials Science at the University of California in Santa Barbara before she started her appointment at UIUC in 2012. Her research interests lie at the intersection of materials science and physical chemistry with a focus on soft materials relevant in biology. Cecilia is the recipient of a 2018 UIUC College of Engineering Dean's Award for Excellence in Research, the 2016 NSF CAREER Award, and the 2016 NIH Director’s New Innovator Award.

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Lecture / Discussion Tue, 16 Oct 2018 17:22:59 -0400 2018-10-25T13:30:00-04:00 2018-10-25T14:30:00-04:00 North Campus Research Complex Building 10 Chemical Engineering Lecture / Discussion
Therapeutic benefit of scaffolds that capture metastatic tumor cells in vivo (December 11, 2018 10:00am) https://events.umich.edu/event/57815 57815-14314713@events.umich.edu Event Begins: Tuesday, December 11, 2018 10:00am
Location: North Campus Research Complex Building 10
Organized By: Biomedical Engineering

For most cancers, the formation of distant metastasis is the point at which clinical treatment shifts from curative intent to extending progression free survival. Physicians are currently unable to diagnose metastasis until disseminated tumor cells affect the function of a target organ as a secondary tumor. This dissertation describes a novel approach where implantable biomaterial scaffolds are used to recruit metastatic tumor cells for early detection prior to colonization of solid organs. This recruitment of tumor cells to a defined site can not only serve as a platform for detection, but can also have therapeutic effects and be used as a platform to study metastatic processes. This dissertation describes work in each of these three areas including using an implantable biomaterial scaffold for early detection, therapeutic benefit, and a platform to study metastasis. The therapeutic benefit of scaffolds was demonstrated by scaffold implantation significantly enhancing disease-free survival in a murine model of triple negative breast cancer. Myeloid derived suppressor cells were the key population of immune cells whose capture at the scaffold and reduction in the spleen and primary tumor lead to enhanced survival. In an effort to probe the contributions of various immune cell types to the formation and maintenance of the pre-metastatic and metastatic niche in vivo, a gene delivery approach was utilized to alter the immune microenvironment of the scaffold and investigate the recruitment of tumor cells, finding reduced immune and tumor cell recruitment with IL-10 delivery and developing a model of tumor cell recruitment that is dependent upon the proportion of each immune cell type in the niche. Additional efforts to use the scaffold to study metastasis included studying scaffold captured tumor cells relative to tumor cells derived from other locations. Scaffold captured tumor cells were a highly aggressive population of metastatic tumor cells similar to those found in a metastatic lung, underscoring the use of the scaffold as a sampling location for metastatic disease that is reflective of tumor cell phenotype in solid organs. Next, biomaterial scaffolds were also validated in transgenic models of both breast and pancreatic cancer to identify immune dysregulation as a function of tumor burden, recruit tumor cells, and to reduce tumor burden. Finally, non-invasive ultrasound imaging and subsequent spectral analysis techniques were applied to identify changes in the scaffold associated with tumor burden and tumor cell recruitment. Taken together, this body of work supports that the implantable biomaterial scaffold technology provides a robust and novel approach for the early detection of metastatic disease in both breast and pancreatic cancer, therapy to divert both pre-metastatic niche forming immune cells and tumor cells themselves to an ectopic site and away from solid organs, and as a platform to study mechanisms of the pre-metastatic niche and metastasis.

Chair: Dr. Lonnie Shea

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Presentation Tue, 20 Nov 2018 16:10:40 -0500 2018-12-11T10:00:00-05:00 2018-12-11T11:00:00-05:00 North Campus Research Complex Building 10 Biomedical Engineering Presentation Biomedical Engineering
ChE Seminar Series: Neel Joshi (December 11, 2018 1:30pm) https://events.umich.edu/event/57894 57894-14366723@events.umich.edu Event Begins: Tuesday, December 11, 2018 1:30pm
Location: North Campus Research Complex Building 10
Organized By: Chemical Engineering

Harvard University
School of Engineering and Applied Sciences
Wyss Institute for Biologically Inspired Engineering

ASTRACT

"Biologically fabricated materials composed of engineered biofilm matrix proteins"

The intersection between synthetic biology and materials science is an under explored area with great potential to positively affect our daily lives, with applications ranging from manufacturing to medicine. My group is interested in harnessing the biosynthetic potential of microbes, not only as factories for the production of raw materials, but as fabrication plants that can orchestrate the assembly of complex functional materials. We call this approach “biologically fabricated materials”, a process whose goal is to genetically program microbes to assemble materials from protein-based building blocks without the need for time consuming and expensive purification protocols or specialized equipment. Accordingly, we have developed Biofilm Integrated Nanofiber Display (BIND), which relies on the biologically directed assembly of biofilm matrix proteins of the curli system in E. coli. We demonstrate that bacterial cells can be programmed to synthesize a range of functional materials with straightforward genetic engineering techniques. The resulting materials are highly customizable and easy to fabricate, and we are investigating their use for practical uses ranging from bioremediation to engineered therapeutic probiotics.

BIO
Neel Joshi is an Associate Professor of Biological Engineering at the Harvard’s School of Engineering and Applied Sciences and also a Core Faculty member at the Wyss Institute for Biologically Inspired Engineering. He completed his PhD at UC Berkeley in the lab of Matt Francis and a postdoc at Boston University in the lab of Mark Grinstaff before starting a position at Harvard. He is broadly interested in topics related to biologically inspired materials, protein engineering, self-assembly, and biointerfaces. His group works at the intersection of biomaterials science and synthetic biology. Recent projects in the group have focused on repurposing bacterial biofilms and their matrix proteins for biotechnological and biomedical applications.

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Lecture / Discussion Mon, 26 Nov 2018 15:08:25 -0500 2018-12-11T13:30:00-05:00 2018-12-11T14:30:00-05:00 North Campus Research Complex Building 10 Chemical Engineering Lecture / Discussion
A Bioethical Lunch on Harry Potter (December 13, 2018 12:00pm) https://events.umich.edu/event/54450 54450-13585501@events.umich.edu Event Begins: Thursday, December 13, 2018 12:00pm
Location: North Campus Research Complex Building 10
Organized By: The Bioethics Discussion Group

A lunchtime discussion on the boy who lived and what that means.

Please RSVP Here
https://goo.gl/forms/oiPBMyqZZ6IEJKtr2

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Lecture / Discussion Wed, 05 Dec 2018 09:34:54 -0500 2018-12-13T12:00:00-05:00 2018-12-13T13:30:00-05:00 North Campus Research Complex Building 10 The Bioethics Discussion Group Lecture / Discussion Harry Potter
Postponed Due to Weather - A Bioethical Lunch on Publishing and Peer Review (January 31, 2019 12:00pm) https://events.umich.edu/event/54451 54451-13585502@events.umich.edu Event Begins: Thursday, January 31, 2019 12:00pm
Location: North Campus Research Complex Building 10
Organized By: The Bioethics Discussion Group

[CANCELED DUE TO THE UNIVERSITY SHUTDOWN. Our apologies.]

A lunchtime discussion on the ethics of publishing in science and the peer-review system, with special guest Nick Kotov.

Please note the location of the event is now at NCRC B10 G065. Sorry about any confusion.

Please RSVP here: https://goo.gl/forms/pTU6Py3FAZn1iSLm1

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Lecture / Discussion Thu, 31 Jan 2019 10:42:45 -0500 2019-01-31T12:00:00-05:00 2019-01-31T13:30:00-05:00 North Campus Research Complex Building 10 The Bioethics Discussion Group Lecture / Discussion Race and gender
David Nordsletten (February 8, 2019 3:00pm) https://events.umich.edu/event/60342 60342-14864286@events.umich.edu Event Begins: Friday, February 8, 2019 3:00pm
Location: North Campus Research Complex Building 10
Organized By: Michigan Institute for Computational Discovery and Engineering

Dr. Nordsletten joined the University of Michigan in January 2019 as an Associate Professor, is a Reader in cardiovascular biomechanics at King’s College London, and is the recipient of the EPSRC HTCA leadership fellowship. His research focuses on the novel application of biomechanics integrated with magnetic resonance imaging (MRI) for the advancement of human cardiovascular health. This broad focus encompasses a range of projects spanning from numerical methods development through to direct analysis of medical imaging data for diagnostics in cardiovascular disease.

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Workshop / Seminar Wed, 06 Feb 2019 12:59:35 -0500 2019-02-08T15:00:00-05:00 2019-02-08T16:00:00-05:00 North Campus Research Complex Building 10 Michigan Institute for Computational Discovery and Engineering Workshop / Seminar Nordsletten
A Bioethical Lunch on Neural Interfaces (February 14, 2019 12:00pm) https://events.umich.edu/event/54452 54452-13585503@events.umich.edu Event Begins: Thursday, February 14, 2019 12:00pm
Location: North Campus Research Complex Building 10
Organized By: The Bioethics Discussion Group

A lunchtime discussion right on the surface of what we think. Special guest, Dr. Parag Patil will regale us with a tale or two.

Please note the location of the event is now at NCRC B10 G065. Sorry about any confusion.

RSVP here: https://goo.gl/forms/JS1HIhzL79diKn1H2

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Lecture / Discussion Thu, 24 Jan 2019 15:16:45 -0500 2019-02-14T12:00:00-05:00 2019-02-14T13:30:00-05:00 North Campus Research Complex Building 10 The Bioethics Discussion Group Lecture / Discussion Neural interfaces
Biosciences Initiative RFA Workshop - North Campus (March 12, 2019 3:00pm) https://events.umich.edu/event/61107 61107-15036257@events.umich.edu Event Begins: Tuesday, March 12, 2019 3:00pm
Location: North Campus Research Complex Building 10
Organized By: Biosciences Initiative

The Biosciences Initiative is hosting a workshop to discuss details regarding the second round of Request for Applications (RFA FY20) for cutting-edge, transdisciplinary biosciences research projects. The Biosciences Initiative Coordinating Committee will be participating in the workshop to answer any questions potential applicants may have.

All are welcome.
Refreshments are provided.

Learn more about this BSI funding opportunity: https://biosciences.umich.edu/funding-opportunities.

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Workshop / Seminar Tue, 12 Feb 2019 12:26:22 -0500 2019-03-12T15:00:00-04:00 2019-03-12T16:30:00-04:00 North Campus Research Complex Building 10 Biosciences Initiative Workshop / Seminar Various Research Projects
A Bioethical Lunch on Mathematical Biology (March 14, 2019 12:00pm) https://events.umich.edu/event/54453 54453-13585504@events.umich.edu Event Begins: Thursday, March 14, 2019 12:00pm
Location: North Campus Research Complex Building 10
Organized By: The Bioethics Discussion Group

A lunchtime discussion on mind-numbing numbers and the biography of our biology.

Please note the location of the event is now at NCRC B10 G065. Sorry about any confusion.

RSVP here: https://goo.gl/forms/BoWDofDjF9sYJDrv1

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Lecture / Discussion Fri, 01 Mar 2019 16:09:59 -0500 2019-03-14T12:00:00-04:00 2019-03-14T13:30:00-04:00 North Campus Research Complex Building 10 The Bioethics Discussion Group Lecture / Discussion Mathematical biology
Feasibility of Using the Utah Array for Long-term Fully Implantable Neuroprosthesis Systems (March 19, 2019 10:00am) https://events.umich.edu/event/62024 62024-15276098@events.umich.edu Event Begins: Tuesday, March 19, 2019 10:00am
Location: North Campus Research Complex Building 10
Organized By: Biomedical Engineering

Damage to the spinal cord can disrupt the pathway of signals sent between the brain and the body and may result in partial or complete loss of both motor and sensory functions. The loss of these functions can have devastating implications on the quality of one’s life, interfering with activities of daily living related to walking, bladder and bowel control, trunk stability, and arm and hand function. Current approaches used to help improve and restore mobility require residual movement to control, which can be unintuitive and inoperative by individuals with higher level cervical injuries. In order to develop technology used by individuals of all levels of injury, it is necessary to generate control signals directly from the brain. This thesis is intended to address the clinical limitations of implantable neural recording systems, and thus lay the foundation for the development of a design and safety profile for a fully implantable intracortical system for motor restoration.

We first present the design and testing of a 96-channel neural recording device used to mate with an existing functional electrical stimulation (FES) system in order to facilitate brain-controlled FES. By extracting signal power within a narrow frequency bandwidth and reducing overhead processer operations, a 25% power reduction is achieved. This establishes the feasibility for an implantable system and enables the integration of the neural recording device with implantable FES system. The specifications of this platform can be used as a guide to develop further application specific modules and dramatically accelerate the overall process to a clinically viable system.

With a functional device, the next step is to move towards a clinical trial. Here we investigate the potential safety risks of future modular, implantable neuroprosthetic systems. A systematic review of 240 articles was used to identify and quantitatively summarize the hardware-related complications of the most established intracranial clinical system, deep brain stimulation, and the most widespread experimental human intracranial system, the NeuroPort, including the Utah microelectrode array. The safety and longevity data collected here will be used to better inform future device and clinical trial design and satisfy regulatory requirements.

The stability and longevity of the Utah array are critical factors for determining whether the clinical benefit outweighs the risk for potential users. We investigate the biological adverse response to the insertion of the Utah array in a rhesus macaque. We examined the health and density of neurons around the shanks of the array in comparison to control brain. Non-human primate animal models allow us to further examine the effects of the implantation of the Utah array on neural tissue, which cannot be done with humans. Information gained through this will continue to increase the pool of safety data for the Utah array and emerging intracranial devices.

Overall, we developed a neural recording device to be used for brain-controlled FES and examined the potential safety concerns reported in the human literature and experimentally using non-human primates. These results represent significant progress towards a clinically-viable system for motor restoration in people suffering from spinal cord injury.

Chair: Cindy Chestek

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Presentation Fri, 15 Mar 2019 15:25:50 -0400 2019-03-19T10:00:00-04:00 2019-03-19T11:00:00-04:00 North Campus Research Complex Building 10 Biomedical Engineering Presentation Biomedical Engineering
The Donald L. Katz Lectureship in Chemical Engineering (April 12, 2019 9:00am) https://events.umich.edu/event/61780 61780-15179597@events.umich.edu Event Begins: Friday, April 12, 2019 9:00am
Location: North Campus Research Complex Building 10
Organized By: Chemical Engineering

Zhenan Bao
K. K. Lee Professor, School of Engineering
Senior Fellow, Precourt Institute for Energy
Stanford University

ABSTRACTS

Lecture 1: April 11, 2019, 5:30 pm
Glick Ballroom, Postma Family Clubhouse

Skin-Inspired Electronics

Skin is the body’s largest organ, and is responsible for the transduction of a vast amount of information. This conformable, stretchable, self-healable and biodegradable material simultaneously collects signals from external stimuli that translate into information such as pressure, pain, and temperature. The development of electronic materials, inspired by the complexity of this organ is a tremendous, unrealized materials challenge. However, the advent of organic-based electronic materials may offer a potential solution to this longstanding problem. In this talk, I will describe the design of organic electronic materials to mimic skin functions. These new materials and new devices enabled arrange of new applications in medical devices, robotics and wearable electronics.




Lecture 2: April 12, 2019, 9:00 am
Research Auditorium, B10 Research Auditorium

Skin-Inspired Electronic Material Design

Future electronics will take more important roles in people’s life. They need to allow more intimate contact with human beings to enable advanced health monitoring, disease detection, medical therapies, and human-machine interfacing. However, current electronics are rigid, non-degradable and cannot self-repair, while the human body is soft, dynamic, stretchable, biodegradable and self-healing. Therefore, it is critical to develop a new class of electronic materials that incorporate skin-like properties, including stretchability for conformable integration, minimal discomfort and suppressed invasive reactions; self-healing for long-term durability under harsh mechanical conditions; and biodegradability for reducing environmental impact and obviating the need for secondary device removal for medical implants. These demands have fueled the development of a new generation of electronic materials, primarily comprised of polymers and polymer composites with both high electrical performance and skin-like properties, and consequently led to a new paradigm of electronics, termed “skin-inspired electronics”. In this talk, I will discuss our general material design concepts to realize skin-like properties without compromising electronic properties. Such fundamental understandings will allow us to further develop skin-inspired materials to meet future requirements for various new applications.

BIO

Zhenan Bao joined Stanford University in 2004. She is currently a K.K. Lee Professor in Chemical Engineering, and with courtesy appointments in Chemistry and Material Science and Engineering. She is the Department Chair of Chemical Engineering from 2018.

She is a member of the National Academy of Engineering and National Academy of Inventors. She founded the Stanford Wearable Electronics Initiative (eWEAR) and is the current faculty director. She is also an affiliated faculty member of Precourt Institute, Woods Institute, ChEM-H and Bio-X. Professor

Bao received her Ph.D. degree in Chemistry from The University of Chicago in 1995 and joined the Materials Research Department of Bell Labs, Lucent Technologies. She became a Distinguished Member of Technical Staff in 2001.

Professor Bao currently has more than 400 refereed publications and more than 60 US patents. She served as a member of Executive Board of Directors for the Materials Research Society and Executive Committee Member for the Polymer Materials Science and Engineering division of the American Chemical Society. She was an Associate Editor for the Royal Society of Chemistry journal Chemical Science, Polymer Reviews and Synthetic Metals.

She serves on the international advisory board for Advanced Materials, Advanced Energy Materials, ACS Nano, Accounts of Chemical Reviews, Advanced Functional Materials, Chemistry of Materials, Chemical Communications, Journal of American Chemical Society, Nature Asian Materials, Materials Horizon and Materials Today. She is one of the Founders and currently sits on the Board of Directors of C3 Nano Co. and PyrAmes, both are silicon valley venture funded companies.

She was a recipient of the Wilhelm Exner Medal from the Austrian Federal Minister of Science in 2018, the L'Oreal UNESCO Women in Science Award North America Laureate in 2017. She was awarded the ACS Applied Polymer Science Award in 2017, ACS Creative Polymer Chemistry Award in 2013 ACS Cope Scholar Award in 2011, and was selected by Phoenix TV, China as 2010 Most influential Chinese in the World-Science and Technology Category. She is a recipient of the Royal Society of Chemistry Beilby Medal and Prize in 2009, IUPAC Creativity in Applied Polymer Science Prize in 2008, American Chemical Society Team Innovation Award 2001, R&D 100 Award, and R&D Magazine Editors Choice Best of the Best new technology for 2001.

She has been selected in 2002 by the American Chemical Society Women Chemists Committee as one of the twelve Outstanding Young Woman Scientist who is expected to make a substantial impact in chemistry during this century. She is also selected by MIT Technology Review magazine in 2003 as one of the top 100 young innovators for this century. She has been selected as one of the recipients of Stanford Terman Fellow and has been appointed as the Robert Noyce Faculty Scholar, Finmeccanica Faculty Scholar and David Filo and Jerry Yang Faculty Scholar.

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Lecture / Discussion Thu, 28 Feb 2019 16:25:23 -0500 2019-04-12T09:00:00-04:00 2019-04-12T10:00:00-04:00 North Campus Research Complex Building 10 Chemical Engineering Lecture / Discussion Zhenan Bao
A Bioethical Lunch on Game of Thrones (April 18, 2019 12:00pm) https://events.umich.edu/event/54454 54454-13585505@events.umich.edu Event Begins: Thursday, April 18, 2019 12:00pm
Location: North Campus Research Complex Building 10
Organized By: The Bioethics Discussion Group

A lunchtime discussion on the bioethics of Westeros and beyond for this lunch and all the lunches to come.

Please note the location of the event is now at NCRC B10 G065. Sorry about any confusion.

RSVP here: https://goo.gl/forms/scE3aM6M5vr1DWbA2

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Lecture / Discussion Thu, 24 Jan 2019 15:21:34 -0500 2019-04-18T12:00:00-04:00 2019-04-18T13:30:00-04:00 North Campus Research Complex Building 10 The Bioethics Discussion Group Lecture / Discussion Game of Thrones
A Bioethical Lunch on Star Wars (May 2, 2019 12:00pm) https://events.umich.edu/event/54455 54455-13585506@events.umich.edu Event Begins: Thursday, May 2, 2019 12:00pm
Location: North Campus Research Complex Building 10
Organized By: The Bioethics Discussion Group

A lunchtime discussion in which the Empire strikes back in this follow-on to our lunch from last year.

Please note the location of the event is now at NCRC B10 G065. Sorry about any confusion.

RSVP here: https://goo.gl/forms/7B6T0XSaovYVuJEz1

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Lecture / Discussion Thu, 24 Jan 2019 15:20:36 -0500 2019-05-02T12:00:00-04:00 2019-05-02T13:30:00-04:00 North Campus Research Complex Building 10 The Bioethics Discussion Group Lecture / Discussion Star Wars
Bio-Hackathon on Aging (May 15, 2019 11:45am) https://events.umich.edu/event/63446 63446-15700290@events.umich.edu Event Begins: Wednesday, May 15, 2019 11:45am
Location: North Campus Research Complex Building 10
Organized By: Biointerfaces Interlaboratory Committees

Are you interested in biomedical research or using your engineering skills to improve the lives of others? Do you have an idea you would like to push to the commercial market?

Join the Biointerfaces Institute Committees (BIONIC) Bio-Hackathon for two free meals and an opportunity to learn from world experts in the the field of aging - Dr. Raymond Yung and Dr. James Ashton-Miller!

Dr. Yung, the Director of the Geriatrics Center and Institute of Gerontology, is an excellent physician who specializes in elderly patients and their unique challenges, from mobility and eyesight to memory and self-care. Dr. Ashton-Miller is a Research Professor of Mechanical Engineering who has done outstanding engineering research in elderly mobility.

Our experts will kickoff the event by highlighting the most pressing areas of elderly need to which Michigan Engineers can make immediate contributions. After an expert-guided brainstorming session, clinical needs will be defined before forming teams, designing solutions and sharing ideas.

To conclude the event, the ideas and preliminary solution models will be compiled into a pre-print research manuscript that will be submitted to bioRxiv with everyone as co-authors! If an idea would like to be pursued further, participants are able to opt out of publishing in the pre-print and can be connected with resources to help take it towards commercialization.

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Other Tue, 30 Apr 2019 10:53:01 -0400 2019-05-15T11:45:00-04:00 2019-05-15T20:00:00-04:00 North Campus Research Complex Building 10 Biointerfaces Interlaboratory Committees Other