Happening @ Michigan https://events.umich.edu/list/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. Biosciences Initiative RFA Workshop - North Campus (March 12, 2019 3:00pm) https://events.umich.edu/event/61107 61107-15036257@events.umich.edu Event Begins: Tuesday, March 12, 2019 3:00pm
Location: North Campus Research Complex Building 10
Organized By: Biosciences Initiative

The Biosciences Initiative is hosting a workshop to discuss details regarding the second round of Request for Applications (RFA FY20) for cutting-edge, transdisciplinary biosciences research projects. The Biosciences Initiative Coordinating Committee will be participating in the workshop to answer any questions potential applicants may have.

All are welcome.
Refreshments are provided.

Learn more about this BSI funding opportunity: https://biosciences.umich.edu/funding-opportunities.

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Workshop / Seminar Tue, 12 Feb 2019 12:26:22 -0500 2019-03-12T15:00:00-04:00 2019-03-12T16:30:00-04:00 North Campus Research Complex Building 10 Biosciences Initiative Workshop / Seminar Various Research Projects
A Bioethical Lunch on Mathematical Biology (March 14, 2019 12:00pm) https://events.umich.edu/event/54453 54453-13585504@events.umich.edu Event Begins: Thursday, March 14, 2019 12:00pm
Location: North Campus Research Complex Building 10
Organized By: The Bioethics Discussion Group

A lunchtime discussion on mind-numbing numbers and the biography of our biology.

Please note the location of the event is now at NCRC B10 G065. Sorry about any confusion.

RSVP here: https://goo.gl/forms/BoWDofDjF9sYJDrv1

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Lecture / Discussion Fri, 01 Mar 2019 16:09:59 -0500 2019-03-14T12:00:00-04:00 2019-03-14T13:30:00-04:00 North Campus Research Complex Building 10 The Bioethics Discussion Group Lecture / Discussion Mathematical biology
Feasibility of Using the Utah Array for Long-term Fully Implantable Neuroprosthesis Systems (March 19, 2019 10:00am) https://events.umich.edu/event/62024 62024-15276098@events.umich.edu Event Begins: Tuesday, March 19, 2019 10:00am
Location: North Campus Research Complex Building 10
Organized By: Biomedical Engineering

Damage to the spinal cord can disrupt the pathway of signals sent between the brain and the body and may result in partial or complete loss of both motor and sensory functions. The loss of these functions can have devastating implications on the quality of one’s life, interfering with activities of daily living related to walking, bladder and bowel control, trunk stability, and arm and hand function. Current approaches used to help improve and restore mobility require residual movement to control, which can be unintuitive and inoperative by individuals with higher level cervical injuries. In order to develop technology used by individuals of all levels of injury, it is necessary to generate control signals directly from the brain. This thesis is intended to address the clinical limitations of implantable neural recording systems, and thus lay the foundation for the development of a design and safety profile for a fully implantable intracortical system for motor restoration.

We first present the design and testing of a 96-channel neural recording device used to mate with an existing functional electrical stimulation (FES) system in order to facilitate brain-controlled FES. By extracting signal power within a narrow frequency bandwidth and reducing overhead processer operations, a 25% power reduction is achieved. This establishes the feasibility for an implantable system and enables the integration of the neural recording device with implantable FES system. The specifications of this platform can be used as a guide to develop further application specific modules and dramatically accelerate the overall process to a clinically viable system.

With a functional device, the next step is to move towards a clinical trial. Here we investigate the potential safety risks of future modular, implantable neuroprosthetic systems. A systematic review of 240 articles was used to identify and quantitatively summarize the hardware-related complications of the most established intracranial clinical system, deep brain stimulation, and the most widespread experimental human intracranial system, the NeuroPort, including the Utah microelectrode array. The safety and longevity data collected here will be used to better inform future device and clinical trial design and satisfy regulatory requirements.

The stability and longevity of the Utah array are critical factors for determining whether the clinical benefit outweighs the risk for potential users. We investigate the biological adverse response to the insertion of the Utah array in a rhesus macaque. We examined the health and density of neurons around the shanks of the array in comparison to control brain. Non-human primate animal models allow us to further examine the effects of the implantation of the Utah array on neural tissue, which cannot be done with humans. Information gained through this will continue to increase the pool of safety data for the Utah array and emerging intracranial devices.

Overall, we developed a neural recording device to be used for brain-controlled FES and examined the potential safety concerns reported in the human literature and experimentally using non-human primates. These results represent significant progress towards a clinically-viable system for motor restoration in people suffering from spinal cord injury.

Chair: Cindy Chestek

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Presentation Fri, 15 Mar 2019 15:25:50 -0400 2019-03-19T10:00:00-04:00 2019-03-19T11:00:00-04:00 North Campus Research Complex Building 10 Biomedical Engineering Presentation Biomedical Engineering
The Donald L. Katz Lectureship in Chemical Engineering (April 12, 2019 9:00am) https://events.umich.edu/event/61780 61780-15179597@events.umich.edu Event Begins: Friday, April 12, 2019 9:00am
Location: North Campus Research Complex Building 10
Organized By: Chemical Engineering

Zhenan Bao
K. K. Lee Professor, School of Engineering
Senior Fellow, Precourt Institute for Energy
Stanford University

ABSTRACTS

Lecture 1: April 11, 2019, 5:30 pm
Glick Ballroom, Postma Family Clubhouse

Skin-Inspired Electronics

Skin is the body’s largest organ, and is responsible for the transduction of a vast amount of information. This conformable, stretchable, self-healable and biodegradable material simultaneously collects signals from external stimuli that translate into information such as pressure, pain, and temperature. The development of electronic materials, inspired by the complexity of this organ is a tremendous, unrealized materials challenge. However, the advent of organic-based electronic materials may offer a potential solution to this longstanding problem. In this talk, I will describe the design of organic electronic materials to mimic skin functions. These new materials and new devices enabled arrange of new applications in medical devices, robotics and wearable electronics.




Lecture 2: April 12, 2019, 9:00 am
Research Auditorium, B10 Research Auditorium

Skin-Inspired Electronic Material Design

Future electronics will take more important roles in people’s life. They need to allow more intimate contact with human beings to enable advanced health monitoring, disease detection, medical therapies, and human-machine interfacing. However, current electronics are rigid, non-degradable and cannot self-repair, while the human body is soft, dynamic, stretchable, biodegradable and self-healing. Therefore, it is critical to develop a new class of electronic materials that incorporate skin-like properties, including stretchability for conformable integration, minimal discomfort and suppressed invasive reactions; self-healing for long-term durability under harsh mechanical conditions; and biodegradability for reducing environmental impact and obviating the need for secondary device removal for medical implants. These demands have fueled the development of a new generation of electronic materials, primarily comprised of polymers and polymer composites with both high electrical performance and skin-like properties, and consequently led to a new paradigm of electronics, termed “skin-inspired electronics”. In this talk, I will discuss our general material design concepts to realize skin-like properties without compromising electronic properties. Such fundamental understandings will allow us to further develop skin-inspired materials to meet future requirements for various new applications.

BIO

Zhenan Bao joined Stanford University in 2004. She is currently a K.K. Lee Professor in Chemical Engineering, and with courtesy appointments in Chemistry and Material Science and Engineering. She is the Department Chair of Chemical Engineering from 2018.

She is a member of the National Academy of Engineering and National Academy of Inventors. She founded the Stanford Wearable Electronics Initiative (eWEAR) and is the current faculty director. She is also an affiliated faculty member of Precourt Institute, Woods Institute, ChEM-H and Bio-X. Professor

Bao received her Ph.D. degree in Chemistry from The University of Chicago in 1995 and joined the Materials Research Department of Bell Labs, Lucent Technologies. She became a Distinguished Member of Technical Staff in 2001.

Professor Bao currently has more than 400 refereed publications and more than 60 US patents. She served as a member of Executive Board of Directors for the Materials Research Society and Executive Committee Member for the Polymer Materials Science and Engineering division of the American Chemical Society. She was an Associate Editor for the Royal Society of Chemistry journal Chemical Science, Polymer Reviews and Synthetic Metals.

She serves on the international advisory board for Advanced Materials, Advanced Energy Materials, ACS Nano, Accounts of Chemical Reviews, Advanced Functional Materials, Chemistry of Materials, Chemical Communications, Journal of American Chemical Society, Nature Asian Materials, Materials Horizon and Materials Today. She is one of the Founders and currently sits on the Board of Directors of C3 Nano Co. and PyrAmes, both are silicon valley venture funded companies.

She was a recipient of the Wilhelm Exner Medal from the Austrian Federal Minister of Science in 2018, the L'Oreal UNESCO Women in Science Award North America Laureate in 2017. She was awarded the ACS Applied Polymer Science Award in 2017, ACS Creative Polymer Chemistry Award in 2013 ACS Cope Scholar Award in 2011, and was selected by Phoenix TV, China as 2010 Most influential Chinese in the World-Science and Technology Category. She is a recipient of the Royal Society of Chemistry Beilby Medal and Prize in 2009, IUPAC Creativity in Applied Polymer Science Prize in 2008, American Chemical Society Team Innovation Award 2001, R&D 100 Award, and R&D Magazine Editors Choice Best of the Best new technology for 2001.

She has been selected in 2002 by the American Chemical Society Women Chemists Committee as one of the twelve Outstanding Young Woman Scientist who is expected to make a substantial impact in chemistry during this century. She is also selected by MIT Technology Review magazine in 2003 as one of the top 100 young innovators for this century. She has been selected as one of the recipients of Stanford Terman Fellow and has been appointed as the Robert Noyce Faculty Scholar, Finmeccanica Faculty Scholar and David Filo and Jerry Yang Faculty Scholar.

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Lecture / Discussion Thu, 28 Feb 2019 16:25:23 -0500 2019-04-12T09:00:00-04:00 2019-04-12T10:00:00-04:00 North Campus Research Complex Building 10 Chemical Engineering Lecture / Discussion Zhenan Bao
A Bioethical Lunch on Game of Thrones (April 18, 2019 12:00pm) https://events.umich.edu/event/54454 54454-13585505@events.umich.edu Event Begins: Thursday, April 18, 2019 12:00pm
Location: North Campus Research Complex Building 10
Organized By: The Bioethics Discussion Group

A lunchtime discussion on the bioethics of Westeros and beyond for this lunch and all the lunches to come.

Please note the location of the event is now at NCRC B10 G065. Sorry about any confusion.

RSVP here: https://goo.gl/forms/scE3aM6M5vr1DWbA2

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Lecture / Discussion Thu, 24 Jan 2019 15:21:34 -0500 2019-04-18T12:00:00-04:00 2019-04-18T13:30:00-04:00 North Campus Research Complex Building 10 The Bioethics Discussion Group Lecture / Discussion Game of Thrones
A Bioethical Lunch on Star Wars (May 2, 2019 12:00pm) https://events.umich.edu/event/54455 54455-13585506@events.umich.edu Event Begins: Thursday, May 2, 2019 12:00pm
Location: North Campus Research Complex Building 10
Organized By: The Bioethics Discussion Group

A lunchtime discussion in which the Empire strikes back in this follow-on to our lunch from last year.

Please note the location of the event is now at NCRC B10 G065. Sorry about any confusion.

RSVP here: https://goo.gl/forms/7B6T0XSaovYVuJEz1

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Lecture / Discussion Thu, 24 Jan 2019 15:20:36 -0500 2019-05-02T12:00:00-04:00 2019-05-02T13:30:00-04:00 North Campus Research Complex Building 10 The Bioethics Discussion Group Lecture / Discussion Star Wars
Bio-Hackathon on Aging (May 15, 2019 11:45am) https://events.umich.edu/event/63446 63446-15700290@events.umich.edu Event Begins: Wednesday, May 15, 2019 11:45am
Location: North Campus Research Complex Building 10
Organized By: Biointerfaces Interlaboratory Committees

Are you interested in biomedical research or using your engineering skills to improve the lives of others? Do you have an idea you would like to push to the commercial market?

Join the Biointerfaces Institute Committees (BIONIC) Bio-Hackathon for two free meals and an opportunity to learn from world experts in the the field of aging - Dr. Raymond Yung and Dr. James Ashton-Miller!

Dr. Yung, the Director of the Geriatrics Center and Institute of Gerontology, is an excellent physician who specializes in elderly patients and their unique challenges, from mobility and eyesight to memory and self-care. Dr. Ashton-Miller is a Research Professor of Mechanical Engineering who has done outstanding engineering research in elderly mobility.

Our experts will kickoff the event by highlighting the most pressing areas of elderly need to which Michigan Engineers can make immediate contributions. After an expert-guided brainstorming session, clinical needs will be defined before forming teams, designing solutions and sharing ideas.

To conclude the event, the ideas and preliminary solution models will be compiled into a pre-print research manuscript that will be submitted to bioRxiv with everyone as co-authors! If an idea would like to be pursued further, participants are able to opt out of publishing in the pre-print and can be connected with resources to help take it towards commercialization.

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Other Tue, 30 Apr 2019 10:53:01 -0400 2019-05-15T11:45:00-04:00 2019-05-15T20:00:00-04:00 North Campus Research Complex Building 10 Biointerfaces Interlaboratory Committees Other
BIONIC Lunch: (The Ethics of) The Business of Biology (July 18, 2019 12:00pm) https://events.umich.edu/event/64111 64111-16153510@events.umich.edu Event Begins: Thursday, July 18, 2019 12:00pm
Location: North Campus Research Complex Building 10
Organized By: The Bioethics Discussion Group

David Canter, Executive Director of the North Campus Research Complex, will be a special guest at this BIONIC/bioethical lunch wherein "the business of biology" will be discussed. Canter, a former Senior Vice President of Pfizer Global Research and Development, brings decades of experience in biomedical sectors to the table, while BIONIC and the Bioethics Discussion Group merely bring the free food.

Please RSVP here: https://docs.google.com/forms/d/e/1FAIpQLSdmBW-GVVT1bY5BExoNfstUPNMJXwywdbY_XyKf-Gti9wfkzg/viewform

We hope to see you there.

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Lecture / Discussion Wed, 03 Jul 2019 09:59:56 -0400 2019-07-18T12:00:00-04:00 2019-07-18T13:00:00-04:00 North Campus Research Complex Building 10 The Bioethics Discussion Group Lecture / Discussion Your in Good Hands
LinkedIn Learning Day (August 8, 2019 8:30am) https://events.umich.edu/event/64081 64081-16115270@events.umich.edu Event Begins: Thursday, August 8, 2019 8:30am
Location: North Campus Research Complex Building 10
Organized By: Organizational Learning

Organizational Learning has teamed up with LinkedIn Learning to show you ways you can support your personal learning goals. Join us for an informational session with a representative from LinkedIn Learning on how to navigate the new platform and how to utilize LinkedIn Learning to best support your goals and growth on your development journey. Charge your mobile device to be ready for a hands-on experience during this workshop.

About LinkedIn Learning:
LinkedIn Learning is an on-demand learning solution designed to help you gain new skills and advance your career, provided for all qualifying benefits-eligible faculty and staff at the university.

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Workshop / Seminar Tue, 09 Jul 2019 22:42:34 -0400 2019-08-08T08:30:00-04:00 2019-08-08T10:00:00-04:00 North Campus Research Complex Building 10 Organizational Learning Workshop / Seminar Organizational Learning and LinkedIn Learning
Future Faculty Writing Series - Research Statement Workshop (August 20, 2019 9:00am) https://events.umich.edu/event/65032 65032-16507303@events.umich.edu Event Begins: Tuesday, August 20, 2019 9:00am
Location: North Campus Research Complex Building 10
Organized By: American Society for Engineering Education Student Chapter

The event will feature a panel of faculty members who have served on search committees talking about what makes an effective research statement. We have also compiled successful research statements from recently hired faculty, as well as tips for the faculty search process. (Please note: Workshop materials will NOT be provided to anyone who does not attend the workshop).

Panelists: Professor Mark Kushner - ECE, Professor Annalisa Manera - NERS, Professor Benjamin Kuipers - CSE, Professor Seymour Spence - CEE, Professor Jianping Fu - ME, and more TBA!

RSVP is required. Space is limited. Lunch will be provided.
https://docs.google.com/forms/d/e/1FAIpQLSfTwBYRki1m5WSbXIm1igCAQmVLD6WQerwL7kUEfnz71ClAFQ/viewform?usp=sf_link

There will also be a writing-accountability group the following Tuesday, August 20th from 9:00-11:00 am in NCRC B10-ACR1, for folks interested in sitting together and incorporating what they learned at the workshop into their own Research Statements (or any other writing they need to work on!). Breakfast will be served.

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Workshop / Seminar Thu, 08 Aug 2019 09:40:30 -0400 2019-08-20T09:00:00-04:00 2019-08-20T11:00:00-04:00 North Campus Research Complex Building 10 American Society for Engineering Education Student Chapter Workshop / Seminar Working together to craft research statements
Precision Health Analytics Platform Roadshow (September 13, 2019 2:00pm) https://events.umich.edu/event/66947 66947-16787735@events.umich.edu Event Begins: Friday, September 13, 2019 2:00pm
Location: North Campus Research Complex Building 10
Organized By: Precision Health

Are you a health researcher looking for genetic and clinical data, or do you need assistance in data analysis?

Precision Health’s new Analytics Platform is a suite of tools, services, and datasets available to researchers across campus--resources previously available only to Michigan Medicine faculty and other level-two password holders. The platform provides campus-wide access to research tools such as DataDirect and services such as consultation with scientific facilitators.

Attend a roadshow to learn how to access the platform and what you can do with it:

• Perform cohort discovery on a database of 4M+ patients
• Query a de-identified, structured dataset of ~60K patients
• Submit queries through the self-serve tool DataDirect
• Access output via a secure, HIPAA-compliant environment
• Request access to linked genetic data (with IRB approval)

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Presentation Wed, 11 Sep 2019 14:58:31 -0400 2019-09-13T14:00:00-04:00 2019-09-13T15:30:00-04:00 North Campus Research Complex Building 10 Precision Health Presentation PH DataDirect
BIONIC Lunch: The Quantified Self (September 24, 2019 12:00pm) https://events.umich.edu/event/63776 63776-15873594@events.umich.edu Event Begins: Tuesday, September 24, 2019 12:00pm
Location: North Campus Research Complex Building 10
Organized By: The Bioethics Discussion Group

A lunchtime discussion on big data, tiny electronics, and the ever shifting boundary between what we know about ourselves and how we measure up to others.

Please RSVP: https://forms.gle/tHcf9gDFAF6YeYHt5

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Lecture / Discussion Mon, 23 Sep 2019 13:59:34 -0400 2019-09-24T12:00:00-04:00 2019-09-24T13:30:00-04:00 North Campus Research Complex Building 10 The Bioethics Discussion Group Lecture / Discussion Quantified self
PhD Defense: Dominique Smith (October 2, 2019 2:00pm) https://events.umich.edu/event/67289 67289-16831267@events.umich.edu Event Begins: Wednesday, October 2, 2019 2:00pm
Location: North Campus Research Complex Building 10
Organized By: Biomedical Engineering

Spinal cord injury (SCI) causes paralysis below the level of injury which, at the cellular level, results from neuron and oligodendrocyte cell death, axonal loss, demyelination, and critically, the limited capacity of spinal cord neurons to regenerate. Although central nervous system (CNS) tissue has the innate capacity to repair the local environment that develops after SCI lacks sufficient factors that promote regeneration and has an abundance of factors that inhibit regeneration. Many strategies have been attempted to aid in the regeneration of CNS tissue, yet re-entry into intact spared tissue remains inadequately low. This is due to the complexity of the spinal cord microenvironment post injury and the barriers that must be addressed to elicit adequate regeneration. The Shea lab has developed multi-channel poly (lactide-co-glycolide) (PLG) bridges to promote spinal cord regeneration and restore functional losses. These bridges are biodegradable and provide a temporary structure that promotes regeneration for between 2 and 6 months post-implantation. The bridges have an interconnected pore structure, that allows infiltration of endogenous cell populations, including macrophages, Schwann cells, oligodendrocytes. Additionally, the bridge mechanically stabilizes the injury with tissue ingrowth and reduces secondary injury and axonal dieback. Longitudinal channels encourage axons to regenerate into the bridge with cells aligned along this major axis. Both motor and sensory axons have been identified in bridge channels. These bridges also serve as a platform for delivery of therapeutics including drugs, cells, and notably lentivirus.

This dissertation investigated the use of lentiviral gene therapy from multi-channel bridges to barriers to regeneration during acute and chronic phases of SCI. We investigated myelination of regenerating axons by over-expression of platelet-derived growth factor-AA (PDGF) and noggin either alone or in combination in an acute mouse SCI model. The combination of noggin + PDGF enhanced total myelination of regenerating axons relative to either factor alone and importantly, enhanced functional recovery relative to the control condition. The increase in myelination was consistent with an increase in oligodendrocyte-derived myelin, which was also associated with a greater density of cells of an oligodendroglial lineage relative to each factor individually and control conditions. We investigated synergistic effects of anti-inflammatory and regenerative factors by bi-cistronic delivery of NT-3 and IL-10 using PLG bridges after acute SCI. The combination of IL-10+NT-3 enhanced axonal growth and oligodendrocyte myelinated axon density significantly over control This resulted in increased locomotor functional recovery compared to IL-10 or NT-3 alone but increased hypersensitivity compared to IL-10 alone. Furthermore, we observed a strong positive correlation between oligodendrocyte myelinated axon density and functional recovery. Lastly, we investigated regeneration using the multi-channel bridge implanted into a chronic SCI following surgical resection of necrotic tissue. We characterized the dynamic injury response and noted that scar formation decreased at 4 and 8 weeks post injury (wpi), yet macrophage infiltration increased between 4 and 8 wpi. Subsequently, scar tissue was resected and bridges were implanted at 4 and 8 wpi. We observed robust axon growth into the bridge and remyelination at 6 months post initial injury. Axon densities were increased for 8 week bridge implantation relative to 4 week bridge implantation, whereas greater myelination, particularly by Schwann cells, was observed with 4 week bridge implantation. Taken together, these results show the bridges as a great tool to manipulate and investigate the spinal cord microenvironment to improve functional outcomes.

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Lecture / Discussion Mon, 16 Sep 2019 16:38:05 -0400 2019-10-02T14:00:00-04:00 North Campus Research Complex Building 10 Biomedical Engineering Lecture / Discussion BME
Precision Health Analytics Platform Roadshow (October 9, 2019 12:00pm) https://events.umich.edu/event/66953 66953-16787745@events.umich.edu Event Begins: Wednesday, October 9, 2019 12:00pm
Location: North Campus Research Complex Building 10
Organized By: Precision Health

Are you a health researcher looking for genetic and clinical data, or do you need assistance in data analysis?

Precision Health’s new Analytics Platform is a suite of tools, services, and datasets available to researchers across campus--resources previously available only to Michigan Medicine faculty and other level-two password holders. The platform provides campus-wide access to research tools such as DataDirect and services such as consultation with scientific facilitators.

Attend a roadshow to learn how to access the platform and what you can do with it:

• Perform cohort discovery on a database of 4M+ patients
• Query a de-identified, structured dataset of ~60K patients
• Submit queries through the self-serve tool DataDirect
• Access output via a secure, HIPAA-compliant environment
• Request access to linked genetic data (with IRB approval)

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Presentation Wed, 18 Sep 2019 12:33:01 -0400 2019-10-09T12:00:00-04:00 2019-10-09T13:30:00-04:00 North Campus Research Complex Building 10 Precision Health Presentation DataDirect
Collegiate Professorship Recognition: Joerg Lahann (October 9, 2019 3:00pm) https://events.umich.edu/event/68226 68226-17028942@events.umich.edu Event Begins: Wednesday, October 9, 2019 3:00pm
Location: North Campus Research Complex Building 10
Organized By: Chemical Engineering

Professor Joerg Lahann will be installed as the Wolfgang Pauli Collegiate Professor of Chemical Engineering and will present a lecture: "Materials, Surfaces, and Converging Interfaces."

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Lecture / Discussion Wed, 09 Oct 2019 12:50:20 -0400 2019-10-09T15:00:00-04:00 2019-10-09T16:00:00-04:00 North Campus Research Complex Building 10 Chemical Engineering Lecture / Discussion Professor Joerg Lahann
Fall Health Communicators Forum (October 17, 2019 3:00pm) https://events.umich.edu/event/67814 67814-16952011@events.umich.edu Event Begins: Thursday, October 17, 2019 3:00pm
Location: North Campus Research Complex Building 10
Organized By: Center for Interprofessional Education

Speakers giving short presentations include:

Kelly B. Sexton, Ph.D., Associate Vice President for Research, Technology Transfer and Innovation

Chris Fick, Ph.D., Senior Director, Business Engagement Center

April Pepperdine, Conflict of Interest Manager, U-M Office of Research

June Anne Insco, Conflict of Interest Manager, U-M Medical
School

Rsvp at https://doodle.com/poll/87zzk4u9txbp2m8u

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Lecture / Discussion Mon, 30 Sep 2019 14:57:47 -0400 2019-10-17T15:00:00-04:00 2019-10-17T16:30:00-04:00 North Campus Research Complex Building 10 Center for Interprofessional Education Lecture / Discussion science translation and communication
BIONIC Lunch: Artificial Intelligence in Medicine (October 22, 2019 12:00pm) https://events.umich.edu/event/63777 63777-15873595@events.umich.edu Event Begins: Tuesday, October 22, 2019 12:00pm
Location: North Campus Research Complex Building 10
Organized By: The Bioethics Discussion Group

Join us for a lunchtime discussion as we assess the computational engines assessing us.

Please RSVP: https://forms.gle/5t6UjXWNA1VSW4fr9

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Lecture / Discussion Mon, 23 Sep 2019 14:00:08 -0400 2019-10-22T12:00:00-04:00 2019-10-22T13:30:00-04:00 North Campus Research Complex Building 10 The Bioethics Discussion Group Lecture / Discussion Artificial Intelligence in Medicine
Complex Systems & Soft Matter Group Seminar | The life and death of turbulence (October 22, 2019 3:00pm) https://events.umich.edu/event/68414 68414-17080052@events.umich.edu Event Begins: Tuesday, October 22, 2019 3:00pm
Location: North Campus Research Complex Building 10
Organized By: The Center for the Study of Complex Systems

A special seminar co-hosted by the Center for the Study of Complex Systems and the Soft Matter Group - Chemical Engineering to be held at the North Campus Research Center

ABSTRACT:
Turbulence is the last great unsolved problem of classical physics. But there is no consensus on what it would mean to actually solve this problem. In this colloquium, I propose that turbulence is most fruitfully regarded as a problem in non-equilibrium statistical mechanics, and will show that this perspective explains turbulent drag behavior measured over 80 years, and makes predictions that have been experimentally tested in 2D turbulent soap films. I will also explain how this perspective is useful in understanding the laminar-turbulence transition, establishing it as a non-equilibrium phase transition whose critical behavior has been predicted and tested experimentally. This work connects transitional turbulence with statistical mechanics and renormalization group theory, high energy hadron scattering, the statistics of extreme events, and even population biology.

___________
To get to the research auditorium, enter via Building 18 Visitors entrance, show ID, up stairs to the right (the big granite egg)

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Workshop / Seminar Tue, 15 Oct 2019 21:31:16 -0400 2019-10-22T15:00:00-04:00 2019-10-22T16:00:00-04:00 North Campus Research Complex Building 10 The Center for the Study of Complex Systems Workshop / Seminar Swanlund Professor of Physics Nigel Goldenfeld
Ph.D. Defense: Dakota Crisp (November 6, 2019 2:00pm) https://events.umich.edu/event/68890 68890-17188749@events.umich.edu Event Begins: Wednesday, November 6, 2019 2:00pm
Location: North Campus Research Complex Building 10
Organized By: Biomedical Engineering

Epilepsy is characterized by spontaneously recurring seizures that severely disrupt quality of life and pose risks of injury and death. It is a highly heterogenous disease, with seizures seen in a wide range of other diseases (Alzheimer’s, autism, Down’s syndrome, etc.). Yet to date, there is no method of categorizing seizures that can help distinguish the link between pathology and seizures. The aim of this work is to validate and explore a method of categorizing seizures based on their fundamental dynamics to provide a framework for future research to better investigate the underlying mechanisms of seizures and therapeutic approaches to stop them.

The first study used predictions from a previously-published computational model to visually classify seizures using dynamical transition features in two large datasets (simulated and real human data). Machine learning was applied to raw signal features to verify the accuracy of the reviewer’s labels. It found that visual classification is consistent and supported by the signal feature analysis. We also investigate the model’s predictions in real human data, finding that most dynamic classifications were observed and patients can have varying seizure dynamics over time. A major unpublished aspect of this work is that the human data analysis was crucial in the original development of the model.

The second study used data mining and machine learning in a long-term rat model of epileptogenesis to investigate the viability of these same dynamic principles as a biomarker of epileptic brain state. It also applied the same rigor to an analysis of the response to electrical stimulation. We found that evoked responses can be used to predict if an injured brain would eventually develop seizures or not. Once seizures began manifesting, both evoked responses and seizure onset dynamics had strong correlation with the progression of epileptogenesis, suggesting they are independent biomarkers.

For the final study, we use the same principles of dynamics and machine learning to characterize differences between a low Mg2+ / high K+ mouse brain-slice seizure model with and without different anti-seizure drugs. It found that anti-seizure drugs can change the observed seizure dynamics, and each drug has a different effect on brain dynamics.

These three studies provide evidence that seizures can be categorized by their fundamental dynamics. These dynamics can provide mechanistic insights into current brain state, future brain states, and the response to anti-epileptic drugs. The results presented in this dissertation can be used as a framework to further investigate seizure mechanisms and personalize patient treatment and research.

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Lecture / Discussion Mon, 28 Oct 2019 15:41:55 -0400 2019-11-06T14:00:00-05:00 2019-11-06T15:00:00-05:00 North Campus Research Complex Building 10 Biomedical Engineering Lecture / Discussion BME Logo
BIONIC Lunch: Precision Health (November 19, 2019 12:00pm) https://events.umich.edu/event/63778 63778-15873596@events.umich.edu Event Begins: Tuesday, November 19, 2019 12:00pm
Location: North Campus Research Complex Building 10
Organized By: The Bioethics Discussion Group

Join us for a lunchtime discussion honing in on the ever truer you.

Please RSVP: https://forms.gle/Zxqo17yGh4PUB46cA

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Lecture / Discussion Mon, 23 Sep 2019 14:00:36 -0400 2019-11-19T12:00:00-05:00 2019-11-19T13:30:00-05:00 North Campus Research Complex Building 10 The Bioethics Discussion Group Lecture / Discussion Precision Health
Ph. D. Defense: Caymen Novak (December 5, 2019 10:00am) https://events.umich.edu/event/69802 69802-17425674@events.umich.edu Event Begins: Thursday, December 5, 2019 10:00am
Location: North Campus Research Complex Building 10
Organized By: Biomedical Engineering

Cells within the body experience a wide range of dynamic mechanical stimuli. These stimuli are exacerbated in cancers and can alter the progression of the disease. As the tumor grows and expands it displaces the surrounding matrix and cell environment creating internal compressive forces and altering interstitial and vascular blood flow thereby enhancing shear stress exposure. How the cells translate this mechano-environment into downstream signaling is known as mechanotransduction. Though preliminary research has touched on the influence physiological mechanical stimulus can have on cancer progression, the work remains erratic and lacks understanding of cell metastasis, gene expression, proliferation, and chemotherapeutic response. In order to address this unknown effect on cellular phenotypes and treatment response, two bioreactors capable of tunable three-dimensional stimulus with either shear stress or compressive forces were developed. Breast and ovarian cancer cells were exposed to physiological stimuli and studied for invasive potential, altered gene expression, proliferation, and chemotherapeutic response. Overall, findings suggest that this dynamic mechanical environment aids in the advancement of cancer migration, proliferation, and chemoresistance which may be mitigated by targeting of various mechanotransduction pathways. The bioreactors constructed and utilized for this study provide 3D platforms ideal for understanding the influence of compressive and shear stress stimulus on cellular behavior, a critical component to our understanding and improvement of cancer patient treatments.

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Lecture / Discussion Tue, 26 Nov 2019 15:14:47 -0500 2019-12-05T10:00:00-05:00 2019-12-05T11:00:00-05:00 North Campus Research Complex Building 10 Biomedical Engineering Lecture / Discussion BME Logo
BIONIC Lunch: Death Positivity (December 17, 2019 12:00pm) https://events.umich.edu/event/63779 63779-15873597@events.umich.edu Event Begins: Tuesday, December 17, 2019 12:00pm
Location: North Campus Research Complex Building 10
Organized By: The Bioethics Discussion Group

Join us for a lunchtime discussion in the mere hours we have remaining.

Please RSVP: https://forms.gle/HK2mP7nMLiB6L9w3A

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Lecture / Discussion Mon, 23 Sep 2019 14:01:00 -0400 2019-12-17T12:00:00-05:00 2019-12-17T13:30:00-05:00 North Campus Research Complex Building 10 The Bioethics Discussion Group Lecture / Discussion Death Positivity