Happening @ Michigan https://events.umich.edu/list/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. Ph.D. Defense: Hina Aftab Khan (April 30, 2019 9:00am) https://events.umich.edu/event/63402 63402-15669549@events.umich.edu Event Begins: Tuesday, April 30, 2019 9:00am
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: Biomedical Engineering

Ovarian cancer is the most lethal gynecologic malignancy among women in the US, responsible for 14,000 deaths per year, and five-year survival rate of 25%. Within the primary and metastatic microenvironments in the ovary, peritoneal ascites and omentum, the ovarian cancer cells are subject to several mechanical stresses, including compressive stresses generated by uncontrolled cell growth in a confining space, increased tissue stiffness due to tumor cell extracellular matrix (ECM) remodeling, and increased interstitial fluid pressure due to the angiogenic growth of new leaky blood vessels. However, current models to study these stimuli within the ovarian tumor microenvironment are lacking in biophysical cues, relevant extracellular matrix dynamics and the ability to consistently sustain cells through the detachment process. The absence of consistent optimization of matrix composition and degradation mechanics also leads to occurrences of increased cytolysis during in vitro experimentation. In order to meet this critical unmet need, my Master’s thesis is focused on developing extracellular matrices that feature comparable consistent compositional, structural and mechanical cues. Additionally, these matrices facilitate biophysical modulation to be applicable over a wider range in a manner that allows for improved experimental precision. Given the range of matrix stiffness, permeability and porosity, I have developed and characterized hydrogels for designing extracellular mimics for ovarian cancer mechanotransduction studies.

In this work, I highlight the need for optimization of interpenetrating network (IPN) hydrogels’ homogeneity, thereby providing uniform adhesion during mechano-transduction experiments. Further, I optimized cell harvesting via thorough cell detachment without causing cytolysis for downstream analysis including, flow cytometry on detached cells. Moreover, I have characterized the rheologic, transport and structural properties of IPN hydrogels, and demonstrate how these can account for variation in experimental results. Overall, my thesis provides insight into the significance of hydrogel matrix composition when constructing cell scaffolds for specific cellular microenvironments.

Owing to their success as natural hydrogel scaffolds, I utilized alginate and agarose to design the ovarian cancer extracellular matrices. Within these networks, collagen served as the second component of the IPN network, providing an anchoring fibrillar network for the cells within the otherwise non-fibrillar material, and further enhancing the biocompatibility of the scaffold. I varied the IPN hydrogel composition to demonstrate a relevant range structural and mechanical properties. Further, I characterized the homogeneity, morphology, fiber structure, stiffness, gelation time, permeability and porosity of IPN hydrogels. Lastly, I evaluated ovarian cancer cells for cellular function post-harvest from IPN hydrogels, to demonstrate successful detachment and degradation of the surrounding matrix.

The results of this study enable tailoring of the IPN hydrogel extracellular matrices according to required mechanical, structural, and biophysical parameters for not only ovarian cancer, but also other originating tissues for improved robustness and reliability of the in vitro cancer bioengineering models.

Chair: Dr. Geeta Mehta

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Presentation Fri, 26 Apr 2019 13:27:56 -0400 2019-04-30T09:00:00-04:00 2019-04-30T10:00:00-04:00 Lurie Biomedical Engineering (formerly ATL) Biomedical Engineering Presentation Biomedical Engineering
Brendan Harley, Sc.D. - BME Guest Speaker (May 14, 2019 4:00pm) https://events.umich.edu/event/63582 63582-15806527@events.umich.edu Event Begins: Tuesday, May 14, 2019 4:00pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: Biomedical Engineering

Advances in the fields of tissue engineering and regenerative medicine require biomaterials that instruct, rather than simply permit, a desired cellular response. A major challenge to progress in our field is the striking cellular and structural heterogeneity of the tissues in our bodies, which can be hierarchical, graded, and heterogeneous over multiple length and time scales. Prof. Harley’s research program is developing approaches to pattern biomaterials at the structural and biomolecular levels to replicate these heterogeneities in order to instruct desired cell behaviors. These efforts seek to provide new insight regarding the degree of biomaterial complexity required to investigate processes related to development, disease, and regeneration. I will describe a collagen biomaterial under development to address barriers preventing regeneration of musculoskeletal tissues such as orthopedic insertions and craniomaxillofacial bones. Here we are using bioinspired design motifs to create composite biomaterials able to improve cell bioactivity and mechanical competence in order to address mechanistic and translational challenges. I will subsequently describe development of a gelatin hydrogel system as well as microfluidic forming techniques to create libraries of optically-translucent hydrogels containing overlapping patterns of cell, matrix, and biomolecule cues. We are using this platform to explore the coordinated impact of structural, biomolecular, and metabolic cues on niche-mediated regulation of hematopoietic stem cell fate as well as invasion and therapeutic resistance in glioblastoma, the most common and lethal form of brain cancer. I will highlight work that employs these platforms to regulate processes such as self-renewal vs. quiescence; signaling and remodeling of artificial perivascular environments; as well as invasion and therapeutic resistance.

Brendan Harley, Sc.D.
Dept. of Chemical & Biomolecular Engineering
Carl R. Woese Institute for Genomic Biology
University of Illinois at Urbana-Champaign
bharley@illinois.edu | www.harleylab.org

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Presentation Mon, 13 May 2019 09:58:04 -0400 2019-05-14T16:00:00-04:00 2019-05-14T17:00:00-04:00 Lurie Biomedical Engineering (formerly ATL) Biomedical Engineering Presentation Biomedical Engineering
IOE 813 Seminar: Amy Kilbourne, PhD, MPH (September 9, 2019 4:30pm) https://events.umich.edu/event/66176 66176-16717507@events.umich.edu Event Begins: Monday, September 9, 2019 4:30pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: U-M Industrial & Operations Engineering

Health systems strive to deliver high-quality, patient-centered care by ensuring that evidence-based, cost-efficient, and acceptable treatment innovations get off the research-academic shelf and into the hands of patients and their providers. However, tracking of this “research-to-practice” translation has found that it can take 17 years for treatment innovations to reach frontline care settings. Moreover, only 1 in 5 of these treatments are ultimately sustained in real-world practice. This research-to-practice gap wastes millions of dollars that are invested in research on treatment discoveries that do not make it into the hands of patients who can ultimately benefit from them. Key barriers to implementing treatment innovations into routine practice include lack of planning to prepare frontline clinicians in their adoption, lack of opportunities to adapt innovations across diverse patient populations, and limited incentives for health care organizations to sustain innovations once the research study ends. This talk will describe novel research approaches to help close the gap between innovation and implementation, notably the new VA Quality Enhancement Research Initiative (QUERI) Implementation Roadmap and accompanying Implementation Strategy Training Hubs. We also describe novel designs such as sequential multiple assignment randomized trial (SMART) and adaptive designs, that can help determine which implementation strategies are most effective in overcoming provider and organizational barriers to treatment adoption, and how these designs and implementation strategies can be applied to settings outside the clinic walls such as schools. We also describe the challenges in conducting these studies to determine the best implementation strategies and the active ingredients for such studies to ultimately inform health systems in the successful spread of innovations to ultimately improve patient outcomes.

Dr. Amy M. Kilbourne, PhD, MPH is Director of the VA Quality Enhancement Research Initiative (QUERI) and Professor of Psychiatry at the University of Michigan (UM) Medical School. With over 40 centers across the U.S., the mission of QUERI is to improve Veteran health by accelerating the implementation of research findings into real-world practice. Dr. Kilbourne’s goal is to improve Veteran health through implementation science, i.e., the use of strategies to help providers scale up and spread effective practices in real-world treatment settings. She has led several national improvement initiatives including a VA national population management program to provide outreach services for Veterans with serious mental illness (Re-Engage) and a community care implementation research roadmap. Dr. Kilbourne is the recipient of several awards including the Presidential Early Career Award for Scientists and Engineers (PECASE) and the Gerald L. Klerman Research Award from the Depression and Bipolar Support Alliance (DBSA). Dr. Kilbourne received her bachelors of arts at the University of California at Berkeley (double major in molecular biology and rhetoric), and her masters in epidemiology and PhD in health policy from the University of California Los Angeles.

This is the first of our weekly seminars this semester. For a full listing of seminars, see https://cheps.engin.umich.edu/seminar-series/2019-seminar-series/

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach.

1123 LBME is room 1123 in the Ann & Robert H. Lurie Biomedical Engineering Building (LBME). The street address is 1101 Beal Avenue. A map and directions are available at: http://www.bme.umich.edu/about/directions.php.

For additional information and to be added to the weekly e-mail for the series, please contact genehkim@umich.edu.

Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Tue, 03 Sep 2019 11:38:24 -0400 2019-09-09T16:30:00-04:00 2019-09-09T18:00:00-04:00 Lurie Biomedical Engineering (formerly ATL) U-M Industrial & Operations Engineering Lecture / Discussion Amy Kilbourne, PhD, MPH
IOE 813 Seminar: Shuai Huang, PhD (September 16, 2019 4:30pm) https://events.umich.edu/event/66783 66783-16796472@events.umich.edu Event Begins: Monday, September 16, 2019 4:30pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: U-M Industrial & Operations Engineering

The data-rich environments in healthcare and ubiquitous use of smartphones hold great promises to accelerate the paradigm transition of U.S. healthcare from reactive care to preventive care. One question is how we could translate the disease data into better care management of patients through an emerging ecosystem of healthcare apps, made possible by smartphones now considered as medical devices. It is known that many diseases manifest complex progression process, involving both temporal dynamics and spatial evolution that could be captured by a rich array of sensors in a smartphone. How could we model, monitor, and modify these processes are challenging problems. For example, diseases such as Alzheimer’s disease and Type 1 Diabetes share the commonality that they involve slow and predictable progression processes. Knowing how a disease progresses is helpful, particularly if we’d like to prevent the disease as early as we could for maximum therapeutic efficacy and improved quality of life. The modeling of the progression process is statistically challenging given the high-dimensionality of the data, the mixed types variables, and the data’s longitudinal nature. Another commonality of these diseases is that, since they are chronic conditions, being able to recognize subtle symptoms that indicate significant clinical events or suggest worse outcomes is crucial for preventative care. Further, patients need to be dynamically prioritized by their projected risk for resource allocation optimization. This needs robust models that build on the statistical knowledge provided by disease modeling and monitoring, to guide the selection of high-risk patients for targeted care. In this talk, I will share some of our works to tackle these challenges by developing novel models and algorithms to provide data-driven decision-making capabilities for better disease management implemented through smartphone apps.

Dr. Shuai Huang is an Associate Professor at the Department of Industrial and Systems Engineering at the University of Washington. He received a B.S. degree on Statistics from the School of Gifted Young at the University of Science and Technology of China in 2007 and a Ph.D. degree on Industrial Engineering from the Arizona State University in 2012. He is also an adjunct faculty member at the Department of Biomedical Informatics and Medical Education (BIME) and the Integrated Brain Imaging Center (IBIC) at the University of Washington. Dr. Huang develops methodologies for modeling, monitoring, diagnosis, and prognosis of complex networked systems such as the brain connectivity networks and disease progression process that have multiple stages and pathways. He also develops statistical and data mining models to integrate massive and heterogeneous datasets such as neuroimaging, genomics, proteomics, laboratory tests, demographics, and clinical variables, for facilitating scientific discoveries in biomedical research and better decision-makings in clinical practices. His research is funded by the National Science Foundation, Defense Advanced Research Projects Agency (DARPA), Juvenile Diabetes Research Foundation (JDRF), Helmsley Foundation, NIH, and several biomedical research institutes. Dr. Huang currently serves as Associate Editor for the IIE Transactions in Healthcare Systems Engineering and Quality Technology and Quantitative Management.

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Lecture / Discussion Thu, 12 Sep 2019 14:53:38 -0400 2019-09-16T16:30:00-04:00 2019-09-16T18:00:00-04:00 Lurie Biomedical Engineering (formerly ATL) U-M Industrial & Operations Engineering Lecture / Discussion Shuai Huang, PhD
ASML Info Session, hosted by TBP (September 17, 2019 6:00pm) https://events.umich.edu/event/66676 66676-16770191@events.umich.edu Event Begins: Tuesday, September 17, 2019 6:00pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: Engineering Career Resource Center

ASML is one of the world’s leading manufacturers of chip-making equipment. We envision a world where semiconductor technology is everywhere and helps tackle society’s toughest challenges. We help support progress by giving leading chip makers the power to mass produce patterns on silicon.

Food will be provided by Jimmy John's.

Majors: Chemical Engineering, Computer Engineering, Computer Science Engineering, Electrical Engineering, Engineering Physics, Industrial and Operations Engineering, Materials Science and Engineering, Mechanical Engineering, Nuclear Engineering and Radiological Sciences

Degrees: Bachelor's, Master's, Ph.D.
Positions: Full-time, intern, and/or co-op
Citizenship Requirement: none
Collecting resumes?: No

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Careers / Jobs Mon, 09 Sep 2019 12:58:24 -0400 2019-09-17T18:00:00-04:00 2019-09-17T19:00:00-04:00 Lurie Biomedical Engineering (formerly ATL) Engineering Career Resource Center Careers / Jobs Lurie Biomedical Engineering (formerly ATL)
Info Session with Exponent, hosted by SWE (September 18, 2019 6:30pm) https://events.umich.edu/event/66454 66454-16736414@events.umich.edu Event Begins: Wednesday, September 18, 2019 6:30pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: Engineering Career Resource Center

Exponent is a leading engineering and scientific consulting firm. Our multidisciplinary team of scientists, engineers, physicians, and regulatory consultants brings together more than 90 different disciplines to solve complicated problems facing corporations, insurers, government entities, associations and individuals. Our approximately 1000 staff members work in 26 offices across the United States and abroad. Exponent has over 800 consultants, including more than 500 that have earned a doctorate in their chosen field of specialization.

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Careers / Jobs Thu, 05 Sep 2019 15:01:39 -0400 2019-09-18T18:30:00-04:00 2019-09-18T20:00:00-04:00 Lurie Biomedical Engineering (formerly ATL) Engineering Career Resource Center Careers / Jobs Lurie Biomedical Engineering (formerly ATL)
IOE 813 Seminar: Kevin Taaffe, PhD (September 23, 2019 4:30pm) https://events.umich.edu/event/66810 66810-16779022@events.umich.edu Event Begins: Monday, September 23, 2019 4:30pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: U-M Industrial & Operations Engineering

Hospitals have introduced information technology to improve the ability of staff to react in a timely fashion, but with mixed success. Hospitals have also continued to build new operating rooms, but advances in patient care and safety are not always evident. In this seminar, we address these two areas of concern regarding day-of-surgery patient flow and safety. Part 1: We describe the development and testing of a mobile application to explore if the use of technology could reduce barriers to communication and coordination on the day of surgery. While staff members in a hospital’s perioperative services department perform their work individually, their choices of upcoming tasks depend on data they can either observe or gather verbally in order to maintain patient flow. Without constant communication with members of other departments, staff may inadvertently select lower priority tasks, which is counter-productive to perioperative services as a whole. The developed mobile application, Periop-MLS, provided each department and its members greater visibility of the workflow. To carry out user testing, the researchers integrated a day-of-surgery discrete event simulation model to communicate with the mobile app to provide realistic scenarios. Through trial-runs of Periop-MLS with staff members, the POS department was able to make proactive coordination and communication decisions. Part 2: It is important to design an operating room layout that can not only improve staff and patient safety but also increase efficiency. In this research, we identify those design factors that influence safety and efficiency through reduced clutter, congestion, and staff walking during surgery. A sample of video-taped surgeries from a large academic hospital were studied to understand the movement of surgical staff during surgery. All activities were coded based on location, activity type, and purpose, and then simulation methodology was used to study the different activity types and movement patterns inside the room. Based on OR size, OR shape, operating table orientation, workstation locations, number of staff, number of doors, and surgery type, we provided critical insight to OR managers and researchers as they determine recommendations for OR design elements and inform the design of future operating rooms.

Kevin M. Taaffe, Ph.D., the Harriet and Jerry Dempsey Professor in Industrial Engineering at Clemson University, has 25 years of industry and academic experience. After receiving B.S. and M.S. degrees in Industrial Engineering from the University of Illinois, Dr. Taaffe worked in the transportation logistics industry (American Airlines, Sabre) for eight years, before returning to academia to obtain his Ph.D. from the University of Florida. Dr. Taaffe’s research interests include the application of simulation and optimization in healthcare, production, and transportation logistics. In particular, Dr. Taaffe focuses on healthcare logistics problems that range from patient flow to operating room management to clinical space capacity management. Dr. Taaffe has worked with clinicians, administrators, managers, and support staff to identify and solve problems related to the patient and staff experience on the day of surgery. Dr. Taaffe began his career working as a transportation planning consultant, and there is a logical research thrust that has resulted from this experience. He has always enjoyed working on industry-sponsored projects that bridge the gap between theoretical research and application. This academic/industry collaboration is a theme of Dr. Taaffe’s interest, as can be seen by his named professorship. Harriet and Jerry Dempsey provided this professorship in an effort to strengthen the research ties between Clemson University and Prisma Health – Upstate.  In addition to his academic and research interests, Dr. Taaffe plays an important role in the Institute of Industrial and Systems Engineers (IISE) where he serves as the Senior VP of North American Operations. In this role, he is helping students and professionals get the most out of their professional organization.

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Lecture / Discussion Tue, 10 Sep 2019 15:17:53 -0400 2019-09-23T16:30:00-04:00 2019-09-23T18:00:00-04:00 Lurie Biomedical Engineering (formerly ATL) U-M Industrial & Operations Engineering Lecture / Discussion Kevin Taaffe, PhD
IOE 813 Seminar: Jim Bagian, MD, PE (September 30, 2019 4:30pm) https://events.umich.edu/event/67675 67675-16915705@events.umich.edu Event Begins: Monday, September 30, 2019 4:30pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: U-M Industrial & Operations Engineering

It has been twenty years since patient safety was thrust into the public and professional consciousness of healthcare. Despite the attention that has been given this complex topic in both the professional and lay press the progress towards making patient safety a real priority in healthcare has been limited. Transforming healthcare so that patient safety becomes an inherent property embedded in the very fabric of the organization requires the adoption of a variety of values, techniques, and processes that are continually  reinforced by the words and deeds of leadership at all levels. Critical elements and methods for achieving this goal will be discussed.

Dr. James P. Bagian is the Director of the Center for Healthcare Engineering and Patient Safety and is a Professor in the  Department of Anesthesiology in the Medical School and the College of Engineering at the University of Michigan. Previously, he served as the first Director of the VA National Center for Patient Safety (NCPS) and the first Chief Patient Safety Officer for the Department of Veterans Affairs from 1999 to 2010 where he developed numerous patient safety related tools and programs that have been adopted nationally and internationally. Dr. Bagian served as a NASA astronaut and is a veteran of two Space Shuttle missions and was an investigator of both the Challenger and Columbia Space Shuttle mishaps. Presently, he is applying systems engineering approaches to the analysis of medical adverse events and the development and implementation of systems-based corrective actions that will enhance patient safety primarily through preventive means. He received his B.S. in mechanical engineering from Drexel University and his M.D. from Jefferson Medical College at Thomas Jefferson University. He is a Fellow of the Aerospace Medical Association, a member of the National Academy of Engineering, the Institute of Medicine, and has received numerous awards for his work in the field of patient safety and aerospace medicine.

1123 LBME is room 1123 in the Ann & Robert H. Lurie Biomedical Engineering Building (LBME). The street address is 1101 Beal Avenue. A map and directions are available at: http://www.bme.umich.edu/about/directions.php.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach.

For additional information and to be added to the weekly e-mail for the series, please contact genehkim@umich.edu.

Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Thu, 26 Sep 2019 09:37:33 -0400 2019-09-30T16:30:00-04:00 2019-09-30T18:00:00-04:00 Lurie Biomedical Engineering (formerly ATL) U-M Industrial & Operations Engineering Lecture / Discussion Jim Bagian
IOE 813 Seminar: Emily Mower Provost, PhD (October 7, 2019 4:30pm) https://events.umich.edu/event/67940 67940-16969030@events.umich.edu Event Begins: Monday, October 7, 2019 4:30pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: U-M Industrial & Operations Engineering

Engineering approaches to human behavior analysis are complicated by the lack of a one-to-one mapping between the behavioral cues that an individual generates and how an external observer interprets those cues. This many-to-many mapping injects noise into both the data and ground truth. As a result, many of the models and assumptions used in traditional machine learning and signal processing must be used with caveats or adapted to meet the needs of this domain. I will discuss our work on algorithmic approaches to characterize and predict how humans perceive signals that modulate spoken communication, focusing on emotion and mood. I will highlight our efforts in tracking mood for individuals with bipolar disorder. These technologies have the potential to forward diagnosis and treatment by providing constrained, repeatable, and easily modifiable assessment protocols, objective measures, and interaction scenarios.

Emily Mower Provost is an Associate Professor in Computer Science and Engineering at the University of Michigan. She received her Ph.D. in Electrical Engineering from the University of Southern California (USC), Los Angeles, CA in 2010. She is a member of Tau-Beta-Pi, Eta-Kappa-Nu, and a member of IEEE and ISCA. She has been awarded a National Science Foundation CAREER Award (2017), a National Science Foundation Graduate Research Fellowship (2004-2007), the Herbert Kunzel Engineering Fellowship from USC (2007-2008, 2010-2011), the Intel Research Fellowship (2008-2010), the Achievement Rewards For College Scientists (ARCS) Award (2009 – 2010), and the Oscar Stern Award for Depression Research (2015). She is a co-author on the paper, "Say Cheese vs. Smile: Reducing Speech-Related Variability for Facial Emotion Recognition," winner of Best Student Paper at ACM Multimedia, 2014, and a co-author of the winner of the Classifier Sub-Challenge event at the Interspeech 2009 emotion challenge. Her research interests are in human-centered speech and video processing, multimodal interfaces design, and speech-based assistive technology. The goals of her research are motivated by the complexities of the perception and expression of human behavior. 

1123 LBME is room 1123 in the Ann & Robert H. Lurie Biomedical Engineering Building (LBME). The street address is 1101 Beal Avenue. A map and directions are available at: http://www.bme.umich.edu/about/directions.php.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach.

For additional information and to be added to the weekly e-mail for the series, please contact genehkim@umich.edu.

Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Wed, 02 Oct 2019 14:59:11 -0400 2019-10-07T16:30:00-04:00 2019-10-07T18:00:00-04:00 Lurie Biomedical Engineering (formerly ATL) U-M Industrial & Operations Engineering Lecture / Discussion Emily Mower Provost, PhD
IOE 813 Seminar: Katie Esper, MPH, MHCDS (October 28, 2019 4:30pm) https://events.umich.edu/event/68702 68702-17138822@events.umich.edu Event Begins: Monday, October 28, 2019 4:30pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: U-M Industrial & Operations Engineering

Katie joined the Johns Hopkins University Applied Physics Laboratory (JHU/APL) in 2010 as a health systems engineer after a few years with a healthcare software company. She has worked directly with the military health system implementing multi-site healthcare delivery initiatives and data driven management systems. Katie’s interests are in population need assessments, practice variation studies, and system design for enterprise wide application. Katie is currently the Program Manager of Force Health and Readiness, overseeing the mission of ensuring a ready medical force, a medically ready force, and the delivery of safe reliable care across all operational settings. In this position, Katie is a strategic thought partner for military leaders and oversees a Warfighter Readiness Performance Improvement portfolio of work.

Katie holds a Bachelor’s degree in Industrial and Operations Engineering from the University of Michigan, a Master’s of Public Health from Johns Hopkins Bloomberg School of Public Health (with a focus in Quality, Patient Safety, and Outcomes Research), and a Master’s in Healthcare Delivery Science from Dartmouth College.

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Lecture / Discussion Tue, 22 Oct 2019 15:03:56 -0400 2019-10-28T16:30:00-04:00 2019-10-28T18:00:00-04:00 Lurie Biomedical Engineering (formerly ATL) U-M Industrial & Operations Engineering Lecture / Discussion Katie Esper
IOE 813 Seminar: Michael Krautmann, MSE (November 4, 2019 4:30pm) https://events.umich.edu/event/68998 68998-17211731@events.umich.edu Event Begins: Monday, November 4, 2019 4:30pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: U-M Industrial & Operations Engineering

Proven medicines and technologies already exist to address many of the world's biggest health challenges. But these products are only effective when they can be reliably delivered to the patients who need them, and in many low- and middle-income countries (LMICs), health product supply chains are not as efficient or reliable as they need to be. Patients and providers often lack access to quality, affordable medicines, and health outcomes suffer as a result.
 
Governments, businesses, multilateral agencies, and nonprofits are all play a critical role in LMIC health supply chains, but each have their own unique perspectives, processes, and goals. Improving supply chain performance in this context requires a systems thinking approach, one that combines traditional logistics management and optimization techniques with a more holistic understanding of how to incentivize and align the actions of diverse organizations.
 
In this session we will explore the William Davidson Institute's work in improving LMIC health supply chain performance, and will highlight lessons and experiences that are applicable in any complex health system environment.

Michael Krautmann joined the William Davidson Institute's Healthcare Initiative in 2015. His research and consulting work focuses on modeling, investment decisionmaking, and strategy development to improve the operational efficiency and service levels of public health supply chains. While at WDI Michael has helped develop several Excel tools and white papers that inform key elements of the supply chain design and strategy development process. He has also conducted strategic evaluations of ongoing supply chain programs in several countries, helping client organizations improve their approach for providing technical assistance and delivering health products.
 
Michael holds master’s and bachelor’s degrees in Industrial and Operations Engineering from the University of Michigan.  Prior to joining WDI, he worked for Lean Care Solutions, a healthcare technology startup that uses predictive analytics to help hospitals improve patient scheduling and postoperative care. He also served as a Peace Corps Volunteer in Zambia, where he helped evaluate clinic-level supply chain practices for a United States Agency for International Development-funded health project.

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Lecture / Discussion Thu, 31 Oct 2019 09:26:56 -0400 2019-11-04T16:30:00-05:00 2019-11-04T18:00:00-05:00 Lurie Biomedical Engineering (formerly ATL) U-M Industrial & Operations Engineering Lecture / Discussion Michael Krautmann, MSE
IOE 813 Seminar: Lavanya Marla, PhD (November 11, 2019 4:30pm) https://events.umich.edu/event/69237 69237-17269241@events.umich.edu Event Begins: Monday, November 11, 2019 4:30pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: U-M Industrial & Operations Engineering

We present an efficient data-driven computational solution and bounding approach for static allocation of an ambulance fleet and its dynamic redeployment, where the goal is to position (or re-position) ambulances to bases to maximize the system's service level. Central to our approach is a discrete-event simulator to evaluate the impact of ambulance deployments to logs of emergency requests. We first model ambulance allocation as an approximately-submodular-maximization problem, and devise a simple and efficient greedy algorithm that produces both static allocations and dynamic repositioning policies. In parallel, we find data-driven information-relaxation bounds for both static and dynamic cases. We build even tighter information-relaxation bounds by penalizing the previous relaxations. Our approach allows the computation of tight bounds without incurring the curse of dimensionality common to such approaches. Our bounding methods help inform policymakers about the viability of proposed fleet sizes and policies being adopted by the contracted EMS agencies. Our computational experiments on an Asian city's EMS demonstrate the tractability and efficiency of our greedy algorithm and our bounding methods.

The first part of this work is with Ramayya Krishnan and Yisong Yue, and the latter part with Achal Bassamboo.

Lavanya Marla is an Assistant Professor in Industrial and Enterprise Systems Engineering at the University of Illinois at Urbana-Champaign. Prior to her current position, she was a Systems Scientist with the Heinz College at Carnegie Mellon University; and earned her PhD in Transportation Systems from MIT and Bachelors degree from IIT Madras. Her research interests are in robust and dynamic decision-making under uncertainty and game theoretic analysis for large-scale transportation and logistics systems; combining tools from data-driven optimization, statistics, simulation and machine learning. Her research is funded by an integrative National Science Foundation grant, a Department of Homeland Security cyber-security grant, the Department of Transportation, the US-India Educational Foundation, the INFORMS Transportation and Logistics Society and aviation companies. Her work has received an Honorable mention for the Anna Valicek award from AGIFORS, a best presentation award from AGIFORS, a KDD Startup Research award, and a Top-10 cited paper recognition from Transportation Research – Part A.

1123 LBME is room 1123 in the Ann & Robert H. Lurie Biomedical Engineering Building (LBME). The street address is 1101 Beal Avenue. A map and directions are available at: https://bme.umich.edu/about/maps-directions/.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach.

For additional information and to be added to the weekly e-mail for the series, please contact genehkim@umich.edu.

Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Thu, 07 Nov 2019 15:23:33 -0500 2019-11-11T16:30:00-05:00 2019-11-11T18:00:00-05:00 Lurie Biomedical Engineering (formerly ATL) U-M Industrial & Operations Engineering Lecture / Discussion Lavanya Marla, PhD
BMES Ice Cream Social (November 15, 2019 4:00pm) https://events.umich.edu/event/69107 69107-17244697@events.umich.edu Event Begins: Friday, November 15, 2019 4:00pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: Biomedical Engineering

Join us for ice cream by Washtenaw Dairy and an opportunity to meet your BME peers! This event is open to all BME students and faculty.

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Social / Informal Gathering Mon, 04 Nov 2019 16:16:12 -0500 2019-11-15T16:00:00-05:00 2019-11-15T18:00:00-05:00 Lurie Biomedical Engineering (formerly ATL) Biomedical Engineering Social / Informal Gathering Ice Cream Social
IOE 813 Seminar: Armagan Bayram, PhD (November 25, 2019 4:30pm) https://events.umich.edu/event/69641 69641-17374460@events.umich.edu Event Begins: Monday, November 25, 2019 4:30pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: U-M Industrial & Operations Engineering

Virtual appointments between patients and healthcare providers can offer a cost-effective alternative to traditional office appointments for managing chronic conditions. Virtual appointments increase contact with the physician by either substituting or complementing office appointments, leading to improved health outcomes. The true value of virtual appointments cannot be realized until they are truly integrated with the office appointment systems. In this study, we introduce a capacity allocation model to study the use of virtual appointments in a chronic care setting. Specifically, we develop a finite horizon stochastic dynamic program to determine which patients to schedule for office and virtual appointments that maximizes aggregate health benefits across a cohort of patients. Optimal policy characterization for this problem is challenging. We find that under certain conditions, a myopic heuristic, where the sickest patients are scheduled for office appointments and the next sickest patients are scheduled for virtual appointments, is optimal. We show that the myopic heuristic performs well even in more general settings. Our findings further show that virtual appointments serve a dual purpose: they may reduce the number of office appointments and may trigger follow-up office appointments.

Dr. Armagan Bayram is an assistant professor in the Department of Industrial and Manufacturing Systems Engineering at University of Michigan – Dearborn. She worked as a postdoctoral fellow in the Department of Industrial Engineering and Management Sciences at Northwestern University. She received her Ph.D. in Management Science from the University of Massachusetts Amherst and M.S. and B.S. degrees in Industrial Engineering from Istanbul Technical University. Dr. Bayram’s research interests include the development of stochastic models and solution methods for capacity and resource allocation problems. Of particular interest are stochastic optimization and dynamic programming models that involve nonprofit and healthcare applications.

1123 LBME is room 1123 in the Ann & Robert H. Lurie Biomedical Engineering Building (LBME). The street address is 1101 Beal Avenue. A map and directions are available at: http://www.bme.umich.edu/about/directions.php.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach.

For additional information and to be added to the weekly e-mail for the series, please contact genehkim@umich.edu.

Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Wed, 20 Nov 2019 10:45:52 -0500 2019-11-25T16:30:00-05:00 2019-11-25T18:00:00-05:00 Lurie Biomedical Engineering (formerly ATL) U-M Industrial & Operations Engineering Lecture / Discussion Center for Healthcare Engineering & Patient Safety
IOE 813 Seminar: Leia Stirling, PhD (December 2, 2019 4:30pm) https://events.umich.edu/event/69766 69766-17417431@events.umich.edu Event Begins: Monday, December 2, 2019 4:30pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: U-M Industrial & Operations Engineering

Wearable sensors provide opportunity to augment occupational therapy through telemedicine. However, there are several design challenges embedded in creating an at-home telemonitoring system that can visualize the complex biomechanical data required for clinical decision making. These challenges include defining performance metrics that correspond to clinical needs and being able to robustly make these measures in a natural environment. In this talk, we describe quantified metrics of motion coordination, balance strategy, and torso compensatory motions. These metrics were informed by clinical observations and were features monitored and synthesized to adapt the selected patient activities.

Leia Stirling is an Associate Professor in Industrial and Operations Engineering at the University of Michigan. Her research quantifies human performance and human-machine fluency to assess performance augmentation, advance exoskeleton control algorithms, mitigate injury risk, and provide relevant feedback to subject matter experts across domains. She received her B.S. (2003) and M.S. (2005) in Aeronautical and Astronautical Engineering from the University of Illinois at Urbana-Champaign, and her Ph.D. (2008) in Aeronautics and Astronautics from MIT. She was a postdoctoral researcher at Boston Children’s Hospital and Harvard Medical School (2008-2009), on the Advanced Technology Team at the Wyss Institute for Biologically Inspired Engineering (2009-2012), then an Assistant Professor at MIT (2013 – 2019). She joined the faculty at the University of Michigan in 2019.

1123 LBME is room 1123 in the Ann & Robert H. Lurie Biomedical Engineering Building (LBME). The street address is 1101 Beal Avenue. A map and directions are available at: http://www.bme.umich.edu/about/directions.php.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach.

For additional information and to be added to the weekly e-mail for the series, please contact genehkim@umich.edu.

Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Mon, 25 Nov 2019 13:25:13 -0500 2019-12-02T16:30:00-05:00 2019-12-02T18:00:00-05:00 Lurie Biomedical Engineering (formerly ATL) U-M Industrial & Operations Engineering Lecture / Discussion Leia Stirling, PhD
IOE 813 Seminar: Amy Cohn, PhD and Krishnan Raghavendran, MBBS (December 9, 2019 4:30pm) https://events.umich.edu/event/70022 70022-17497479@events.umich.edu Event Begins: Monday, December 9, 2019 4:30pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: U-M Industrial & Operations Engineering

Specializing in trauma, burn, surgical critical care, and emergency surgery areas, the surgeons in the Division of Acute Care Surgery at Michigan Medicine care for our most critically injured patients. Ensuring that this team is able to properly staff its units at all times is essential to Michigan Medicine’s mission and role as a Level 1 Trauma Center and Burn Verified Center. However, traditional methods for scheduling healthcare providers are time-intensive and may fail to meet the needs of the providers and units they serve. For Acute Care Surgery, the task of creating the schedules, which often follows a complex set of rules and preferences, falls on the Division Chief, consuming valuable time and sometimes not satisfying each surgeon’s preferences. To improve this process, we have created a computerized decision-making tool to ease the burden of creating such schedules. We formulated an integer program to automate the creation of this department’s six-month-long schedule, which assigns 15 attending surgeons to 5 units for weekly time intervals. Users can input schedule parameters such as the attending surgeons’ time-off requests and targeted number of weeks on service. Moreover, metrics enable generating the highest-quality schedule that simultaneously meets the needs of the department, the surgeons’ preferences, and balances the schedule fairly. This scheduling tool has drastically decreased the production time of the schedule. Whereas previously creating the six-month schedule required multiple weeks of the division chief’s time, using the scheduling tool requires only a few hours of the division chief’s time. Additionally, the transparent schedule metrics defined by the tool can increase a sense of fairness among surgeons, increasing job satisfaction and reducing physician burnout.

Amy Cohn, PhD, joined the faculty in the Department of Industrial and Operations Engineering at the University of Michigan in 2002 as an Assistant Professor and was promoted to Associate Professor in 2009; in 2011, she was also named a Thurnau Professor and in 2017 was promoted to Full Professor. She currently holds the position of Associate Director for the Center for Healthcare Engineering and Patient Safety. Her primary research interest is in robust and integrated planning for large-scale systems, predominantly in healthcare and aviation applications. She also collaborates on projects in satellite communications, vehicle routing problems for hybrid fleets, and robust network design for power systems and related applications. Her primary teaching interest is in optimization techniques, at both the graduate and undergraduate level.

Dr. Raghavendran is Professor of Surgery and the Division chief of Acute Care Surgery, Section of General Surgery. He received his medical education in India and immigrated to the United States in 1991, wherein he completed his Surgical Residency and subsequent fellowship in Surgical Critical Care Dr. Raghavendran has been continuously funded by the National Institutes of Health (NIH) from both NIGMS and NHLBI for the past 14 years. The current R-01 is on the study of Hypoxia-inducible factor 1 α in the pathogenesis of acute inflammatory response following lung contusion. The focus of his clinical interest is with ARDS and ventilator-associated pneumonia.He currently serves as the director of the newly formed Michigan Center for global surgery. Additionally, he serves as the lead physician for the University of Michigan India collaborative. He has also received funding from the NIH US/India collaborative with an R-03 award examining the role of ultrasound and measurement of optic nerve sheath diameter as a surrogate marker for traumatic brain injury.

1123 LBME is room 1123 in the Ann & Robert H. Lurie Biomedical Engineering Building (LBME). The street address is 1101 Beal Avenue. A map and directions are available at: http://www.bme.umich.edu/about/directions.php.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach.

For additional information and to be added to the weekly e-mail for the series, please contact genehkim@umich.edu.

Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Thu, 05 Dec 2019 11:43:02 -0500 2019-12-09T16:30:00-05:00 2019-12-09T18:00:00-05:00 Lurie Biomedical Engineering (formerly ATL) U-M Industrial & Operations Engineering Lecture / Discussion Amy Cohn, PhD and Krishnan Raghavendran, MBBS
BME Student Speaker: Xiaotian Tan (February 3, 2020 12:00pm) https://events.umich.edu/event/72234 72234-17963872@events.umich.edu Event Begins: Monday, February 3, 2020 12:00pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: Biomedical Engineering

Biosensors are devices or systems that can be used to detect, quantify, and analyze targets with biological activities and functions. As one of the largest subsets of biosensors, biomolecular sensors are specifically developed and programmed to detect, quantify and analyze biomolecules in liquid samples. Wide-ranging applications have made immunoassays increasingly popular for biomolecular detection and quantification. Among these, enzyme-linked immunosorbent assays (ELISA) are of particular interest due to high specificity and reproducibility. To some extent, ELISA has been regarded as a “gold standard” for quantifying analytes (especially protein analytes) in both clinical diagnostics and fundamental biological research. However, traditional (96-well plate-based) ELISA still suffers from several notable drawbacks, such as long assay time (4–6 hours), lengthy procedures, and large sample/reagent consumption (∼100 μL). These inherent disadvantages still significantly limit traditional ELISA's applicability to areas such as rapid clinical diagnosis of acute diseases (e.g., viral pneumonia, acute organ rejection), and biological research that requires accurate measurements with precious or low abundance samples (e.g., tail vein serum from a mouse). Thus, a bimolecular sensing technology that has high sensitivity, short assay time, and small sample/reagent consumption is still strongly desired. In this dissertation, we introduce the development of a multifunctional and automated optofluidic biosensing platform that can resolve the aforementioned problems. In contrast to conventional plate-based ELISA, our optofluidic ELISA platform utilizes mass-producible polystyrene microfluidic channels with a high surface-to-volume ratio as the immunoassay reactors, which greatly shortens the total assay time. We also developed a low-noise signal amplification protocol and an optical signal quantification system that was optimized for the optofluidic ELISA platform. Our optofluidic ELISA platform provides several attractive features such as small sample/reagent consumption (<8 μL), short total assay time (30-45 min), high sensitivity (~1 pg/mL for most markers), and a broad dynamic range (3-4 orders of magnitude). Using these features, we successfully quantified mouse FSH (follicle stimulating hormone) concentration with a single drop of tail vein serum. We also successfully monitored bladder cancer progression in orthotopic xenografted mice with only <50 μL of mouse urine. More excitingly, we achieved highly-sensitive exosome quantification and multiplexed immuno-profiling with <40 ng/mL of total input protein (per assay). These remarkable milestones could not be achieved with conventional plate-based ELISA but were enabled by our unique optofluidic ELISA.

As an emerging member of the bimolecular sensor family, our optofluidic ELISA platform provides a high-performance and cost-effective tool for a plethora of applications, including endocrinal, cancer animal model, cellular biology, and even forensic science research. In the future, this technology platform can also be renovated for clinical applications such as personalized cancer diagnosis/prognosis and rapid point-of-care diagnostics for infectious diseases.

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Lecture / Discussion Thu, 30 Jan 2020 09:19:52 -0500 2020-02-03T12:00:00-05:00 2020-02-03T13:00:00-05:00 Lurie Biomedical Engineering (formerly ATL) Biomedical Engineering Lecture / Discussion Xiaotian Tan
STEM Identities and the UM Experience (February 10, 2020 5:30pm) https://events.umich.edu/event/72267 72267-17966041@events.umich.edu Event Begins: Monday, February 10, 2020 5:30pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: MUSES

How has your identity impacted your experience at U-M? Engage in welcoming group conversations to unpack how troubling individual experiences have common threads. Groups will brainstorm solutions we can enact and strategies we can use to move forward and address issues we’re facing on campus. Be on the lookout for future events like this! Dinner provided!
Please RSVP: https://bit.ly/2NvYMMx

Date: Mon, Feb. 10th
Time: 5:30-7:30pm
Location: Johnson Rooms, 3rd Floor, Lurie Engineering Center

Co-Sponsors: SHPE-GC, GSBES, MUSES, GEO, SFTP, MSE GSC, ME Dept, and CoE OSA.

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Meeting Thu, 30 Jan 2020 14:26:41 -0500 2020-02-10T17:30:00-05:00 2020-02-10T19:30:00-05:00 Lurie Biomedical Engineering (formerly ATL) MUSES Meeting Different people with different identities celebrating and doing different things
ECRC + BME Cookies & Careers (February 18, 2020 10:00am) https://events.umich.edu/event/72300 72300-17972520@events.umich.edu Event Begins: Tuesday, February 18, 2020 10:00am
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: Engineering Career Resource Center

Biomedical Engineering Students - Are you getting ready for the BME Career Pathways Expo? Stop by for a quick resume review or chat with an ECRC Advisor about your job search!

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Careers / Jobs Fri, 31 Jan 2020 10:04:54 -0500 2020-02-18T10:00:00-05:00 2020-02-18T12:00:00-05:00 Lurie Biomedical Engineering (formerly ATL) Engineering Career Resource Center Careers / Jobs Lurie Biomedical Engineering (formerly ATL)
UK Scholarships! (February 19, 2020 5:00pm) https://events.umich.edu/event/72128 72128-17940038@events.umich.edu Event Begins: Wednesday, February 19, 2020 5:00pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: Office of National Scholarships & Fellowships (ONSF)

Join Dr. Henry Dyson, Director of ONSF, to learn about the incredible opportunities available to study in the United Kingdom! Programs like the Rhodes Scholarship and Marshall Scholarship draw thousands of applicants a year, for U-M applicants, the journey often starts with ONSF.

This is a sample of the UK Scholarships we will cover during this information session:

Rhodes Scholarship: Full funding for 2-3 years of graduate study at Oxford University in any field
Marshall Scholarship: Funds two years of graduate study at any UK institution in a wide variety of fields
Gates Cambridge Scholarship: Full funding for any graduate program at Cambridge in any field
Churchill Scholarship: Funds one year of graduate research and study in a STEM field at Cambridge

Register for this event: https://myumi.ch/er9q4

Find more opportunities on the ONSF Website! https://lsa.umich.edu/onsf

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Presentation Mon, 27 Jan 2020 17:39:42 -0500 2020-02-19T17:00:00-05:00 2020-02-19T18:00:00-05:00 Lurie Biomedical Engineering (formerly ATL) Office of National Scholarships & Fellowships (ONSF) Presentation Big Ben