Happening @ Michigan https://events.umich.edu/list/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. BME Student Speaker: Xiaotian Tan (February 3, 2020 12:00pm) https://events.umich.edu/event/72234 72234-17963872@events.umich.edu Event Begins: Monday, February 3, 2020 12:00pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: Biomedical Engineering

Biosensors are devices or systems that can be used to detect, quantify, and analyze targets with biological activities and functions. As one of the largest subsets of biosensors, biomolecular sensors are specifically developed and programmed to detect, quantify and analyze biomolecules in liquid samples. Wide-ranging applications have made immunoassays increasingly popular for biomolecular detection and quantification. Among these, enzyme-linked immunosorbent assays (ELISA) are of particular interest due to high specificity and reproducibility. To some extent, ELISA has been regarded as a “gold standard” for quantifying analytes (especially protein analytes) in both clinical diagnostics and fundamental biological research. However, traditional (96-well plate-based) ELISA still suffers from several notable drawbacks, such as long assay time (4–6 hours), lengthy procedures, and large sample/reagent consumption (∼100 μL). These inherent disadvantages still significantly limit traditional ELISA's applicability to areas such as rapid clinical diagnosis of acute diseases (e.g., viral pneumonia, acute organ rejection), and biological research that requires accurate measurements with precious or low abundance samples (e.g., tail vein serum from a mouse). Thus, a bimolecular sensing technology that has high sensitivity, short assay time, and small sample/reagent consumption is still strongly desired. In this dissertation, we introduce the development of a multifunctional and automated optofluidic biosensing platform that can resolve the aforementioned problems. In contrast to conventional plate-based ELISA, our optofluidic ELISA platform utilizes mass-producible polystyrene microfluidic channels with a high surface-to-volume ratio as the immunoassay reactors, which greatly shortens the total assay time. We also developed a low-noise signal amplification protocol and an optical signal quantification system that was optimized for the optofluidic ELISA platform. Our optofluidic ELISA platform provides several attractive features such as small sample/reagent consumption (<8 μL), short total assay time (30-45 min), high sensitivity (~1 pg/mL for most markers), and a broad dynamic range (3-4 orders of magnitude). Using these features, we successfully quantified mouse FSH (follicle stimulating hormone) concentration with a single drop of tail vein serum. We also successfully monitored bladder cancer progression in orthotopic xenografted mice with only <50 μL of mouse urine. More excitingly, we achieved highly-sensitive exosome quantification and multiplexed immuno-profiling with <40 ng/mL of total input protein (per assay). These remarkable milestones could not be achieved with conventional plate-based ELISA but were enabled by our unique optofluidic ELISA.

As an emerging member of the bimolecular sensor family, our optofluidic ELISA platform provides a high-performance and cost-effective tool for a plethora of applications, including endocrinal, cancer animal model, cellular biology, and even forensic science research. In the future, this technology platform can also be renovated for clinical applications such as personalized cancer diagnosis/prognosis and rapid point-of-care diagnostics for infectious diseases.

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Lecture / Discussion Thu, 30 Jan 2020 09:19:52 -0500 2020-02-03T12:00:00-05:00 2020-02-03T13:00:00-05:00 Lurie Biomedical Engineering (formerly ATL) Biomedical Engineering Lecture / Discussion Xiaotian Tan
STEM Identities and the UM Experience (February 10, 2020 5:30pm) https://events.umich.edu/event/72267 72267-17966041@events.umich.edu Event Begins: Monday, February 10, 2020 5:30pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: MUSES

How has your identity impacted your experience at U-M? Engage in welcoming group conversations to unpack how troubling individual experiences have common threads. Groups will brainstorm solutions we can enact and strategies we can use to move forward and address issues we’re facing on campus. Be on the lookout for future events like this! Dinner provided!
Please RSVP: https://bit.ly/2NvYMMx

Date: Mon, Feb. 10th
Time: 5:30-7:30pm
Location: Johnson Rooms, 3rd Floor, Lurie Engineering Center

Co-Sponsors: SHPE-GC, GSBES, MUSES, GEO, SFTP, MSE GSC, ME Dept, and CoE OSA.

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Meeting Thu, 30 Jan 2020 14:26:41 -0500 2020-02-10T17:30:00-05:00 2020-02-10T19:30:00-05:00 Lurie Biomedical Engineering (formerly ATL) MUSES Meeting Different people with different identities celebrating and doing different things
ECRC + BME Cookies & Careers (February 18, 2020 10:00am) https://events.umich.edu/event/72300 72300-17972520@events.umich.edu Event Begins: Tuesday, February 18, 2020 10:00am
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: Engineering Career Resource Center

Biomedical Engineering Students - Are you getting ready for the BME Career Pathways Expo? Stop by for a quick resume review or chat with an ECRC Advisor about your job search!

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Careers / Jobs Fri, 31 Jan 2020 10:04:54 -0500 2020-02-18T10:00:00-05:00 2020-02-18T12:00:00-05:00 Lurie Biomedical Engineering (formerly ATL) Engineering Career Resource Center Careers / Jobs Lurie Biomedical Engineering (formerly ATL)
UK Scholarships! (February 19, 2020 5:00pm) https://events.umich.edu/event/72128 72128-17940038@events.umich.edu Event Begins: Wednesday, February 19, 2020 5:00pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: Office of National Scholarships & Fellowships (ONSF)

Join Dr. Henry Dyson, Director of ONSF, to learn about the incredible opportunities available to study in the United Kingdom! Programs like the Rhodes Scholarship and Marshall Scholarship draw thousands of applicants a year, for U-M applicants, the journey often starts with ONSF.

This is a sample of the UK Scholarships we will cover during this information session:

Rhodes Scholarship: Full funding for 2-3 years of graduate study at Oxford University in any field
Marshall Scholarship: Funds two years of graduate study at any UK institution in a wide variety of fields
Gates Cambridge Scholarship: Full funding for any graduate program at Cambridge in any field
Churchill Scholarship: Funds one year of graduate research and study in a STEM field at Cambridge

Register for this event: https://myumi.ch/er9q4

Find more opportunities on the ONSF Website! https://lsa.umich.edu/onsf

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Presentation Mon, 27 Jan 2020 17:39:42 -0500 2020-02-19T17:00:00-05:00 2020-02-19T18:00:00-05:00 Lurie Biomedical Engineering (formerly ATL) Office of National Scholarships & Fellowships (ONSF) Presentation Big Ben