Happening @ Michigan https://events.umich.edu/list/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. Alum|NUM (August 11, 2022 9:00am) https://events.umich.edu/event/95038 95038-21788375@events.umich.edu Event Begins: Thursday, August 11, 2022 9:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Physical
TBA

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Other Thu, 11 Aug 2022 18:15:34 -0400 2022-08-11T09:00:00-04:00 2022-08-11T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Merck symposium 2022 (August 18, 2022 9:00am) https://events.umich.edu/event/96202 96202-21792034@events.umich.edu Event Begins: Thursday, August 18, 2022 9:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Physical
Christopher Vanderwal (UC-Irvine)

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Other Thu, 18 Aug 2022 18:15:32 -0400 2022-08-18T09:00:00-04:00 2022-08-18T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Making Sense of Mechanisms: Studies on Learning Organic Chemistry (September 8, 2022 4:00pm) https://events.umich.edu/event/95970 95970-21791508@events.umich.edu Event Begins: Thursday, September 8, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Learning is a difficult, multidimensional process; educators have a responsibility to be aware of our students’ learning progress and respond to that awareness in ways that further promote learning. For the Raker Research Group, we are focused on understanding how novices develop and use the language of organic chemistry, i.e. how learners come to make sense of reaction mechanisms. This broader outcome for our course requires the activation and integration of multiple concepts and skills that have been shown to be difficult for learners. The focus of our work is on foundational concepts including acidity and basicity, and nucleophiles and electrophiles in the context of studying how learners make sense of mechanisms. We develop rubrics to measure learning and evaluate instruction, and construct learning experiences that supplement and complement instruction. We have been successful in using our rubrics to develop computer-based scoring models to evaluate 20,000+ written reaction mechanism explanations across the undergraduate organic chemistry curriculum. For our Lewis acid–base scoring model, we have demonstrated that the model can be deployed in adaptative tutorials to provide and promote targeted learning. While our work has specifically focused on organic chemistry, implications of our work extend to all areas of chemistry: to provide meaningful learning experiences for our students, we must have good tools to measure learning and work to create experiences that better and best promote that learning. Thus, molecular orbital diagrams in inorganic chemistry, phase diagrams in physical chemistry, or enzyme-substrate kinetics in biochemistry, for example, all provide contexts in our courses for reflecting on and responding to learning that requires integration of concepts and skills similar to how we do chemistry.




Jeffrey Raker (University of South Florida)

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Other Thu, 08 Sep 2022 18:15:32 -0400 2022-09-08T16:00:00-04:00 2022-09-08T17:15:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Muslims of the Heartland: How Ottoman Syrians Made a Home in the American Midwest (September 8, 2022 4:00pm) https://events.umich.edu/event/96757 96757-21793267@events.umich.edu Event Begins: Thursday, September 8, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Arab and Muslim American Studies (AMAS)

Arab American author Edward E. Curtis IV is the William M. and Gail M. Plater Chair of the Liberal Arts at Indiana University, Indianapolis. The author or editor of fourteen books about Black, Muslim, and Arab American history and life, he has received major fellowships and grants from Carnegie, Fulbright, Luce, Mellon, and the National Endowment for the Humanities.

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Lecture / Discussion Thu, 11 Aug 2022 15:59:34 -0400 2022-09-08T16:00:00-04:00 2022-09-08T18:00:00-04:00 Chemistry Dow Lab Arab and Muslim American Studies (AMAS) Lecture / Discussion Poster of the event.
Illuminating the Biochemical Activity Architecture of the Cell (September 12, 2022 4:00pm) https://events.umich.edu/event/95569 95569-21790344@events.umich.edu Event Begins: Monday, September 12, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


Jin Zhang (University of California, San Diego)

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Other Mon, 12 Sep 2022 18:15:26 -0400 2022-09-12T16:00:00-04:00 2022-09-12T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Graham DeRuiter (September 13, 2022 4:00pm) https://events.umich.edu/event/90523 90523-21671305@events.umich.edu Event Begins: Tuesday, September 13, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Inorganic
Graham DeRuiter

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Other Wed, 08 Jun 2022 12:15:08 -0400 2022-09-13T16:00:00-04:00 2022-09-13T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Catalyst RE-Design: Dynamic, Reactive, and Selective Systems for Oxygenated Polymer Synthesis (September 20, 2022 4:00pm) https://events.umich.edu/event/95777 95777-21790892@events.umich.edu Event Begins: Tuesday, September 20, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Polymer waste has quickly become one of our society\'s largest looming environmental concerns, where an estimated 4.9 GTons of polymer waste currently exist in the environment. Central to addressing this challenge is the generation of polymers with robust materials properties that embed or encode end-of-use. Oxygenated (co)polymers such as polyhydroxyalkanoates are naturally occurring and fully bioresorbable polymers with promising materials properties, yet their efficient and cost-effective stereospecific synthesis remains challenging. In this talk, I will share some of our group\'s recent advances in catalyst development for the synthesis of oxygenated (co)polymers. Specifically, we\'ll discuss how new catalyst design strategies which fully leverage the high metal-ligand lability of the rare-earth elements can lead to systems which are highly dynamic, reactive, and selective.

Jerome Robinson (Brown)

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Other Tue, 20 Sep 2022 18:15:24 -0400 2022-09-20T16:00:00-04:00 2022-09-20T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Investigating Sociocultural and Environmental Factors Related to Students’ Chemistry Identity Development (September 27, 2022 4:00pm) https://events.umich.edu/event/94228 94228-21726176@events.umich.edu Event Begins: Tuesday, September 27, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

ChemEd
Justin Carmel (Florida International University)

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Other Tue, 27 Sep 2022 18:15:25 -0400 2022-09-27T16:00:00-04:00 2022-09-27T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Incorporation and molecular level consequences of mRNA modifications (September 29, 2022 4:00pm) https://events.umich.edu/event/96495 96495-21792591@events.umich.edu Event Begins: Thursday, September 29, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Cells face the daunting task of maintaining the right number of proteins, at the right time, under rapidly changing conditions. One way that nature accomplishes this is by chemically modifying DNA, RNA and protein molecules to control their structure, function, stability and localization. A single cell possesses thousands of enzymatically modified RNA sites. These modifications have the potential to directly impact protein production, and disruptions in the RNA modification landscape are associated with an array of diseases including cancers, neurological diseases, and diabetes. Nonetheless, it remains to be discovered how individual sites of modification influence the function of a given RNA. We are working to ascertain how modifications to the molecular blueprints for protein synthesis, messenger RNAs (mRNAs), influence protein production. Our studies have led to the discovery of new mRNA modifications, reframed the current model for RNA modifying enzyme target selection, and identified modifications that change the speed and accuracy of protein synthesis. These findings lay the foundation for establishing complex rules governing the molecular level consequences of mRNA modifications.
Kristin Koutmou

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Other Thu, 29 Sep 2022 18:15:25 -0400 2022-09-29T16:00:00-04:00 2022-09-29T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Optogenetic Feedback Control of Gene Expression and Antibiotic Resistance in Single Cells (September 30, 2022 12:00pm) https://events.umich.edu/event/97236 97236-21794168@events.umich.edu Event Begins: Friday, September 30, 2022 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Cell-to-cell heterogeneity in gene expression can elevate antibiotic resistance in one microbe while other cells remain susceptible. These transient forms of drug resistance are often stochastic and dynamic, leading to single-cell level differences in resistance that change with time. To date, methods for quantifying these effects have relied on careful observations of native expression patterns. In this talk, I will discuss a novel approach for controlling gene expression dynamics in single cells that can be used to precisely drive expression in thousands of cells in parallel. In support of this, I will discuss our recent advances in automated image processing of time-lapse microscopy data using deep learning models (DeLTA). Once trained, the DeLTA algorithm requires minimal input from the user and can rapidly segment, track, and reconstruct lineages for bacteria growing in microfluidic chips and on two dimensional surfaces. I will also discuss optogenetic control methods that allow us to use light-based feedback to regulate gene expression in real time. Using a combination of deep learning-based models and rapid image analysis, we can simultaneously control gene expression in thousands of cells in parallel. Together, these approaches offer powerful methods that can be used to quantify and control cell-to-cell heterogeneity in antibiotic resistance, providing a detailed view into strategies bacteria can use to evade drug treatment.

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Workshop / Seminar Mon, 26 Sep 2022 09:56:19 -0400 2022-09-30T12:00:00-04:00 2022-09-30T13:30:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
Natural Product Discovery and Biosynthesis in the Post-genomic Era (October 4, 2022 4:00pm) https://events.umich.edu/event/94405 94405-21738304@events.umich.edu Event Begins: Tuesday, October 4, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Chembio
Mohammad Seyedsayamdost (Princeton)

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Other Tue, 04 Oct 2022 18:15:24 -0400 2022-10-04T16:00:00-04:00 2022-10-04T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Electrifying Material and Organic Synthesis (October 6, 2022 4:00pm) https://events.umich.edu/event/95988 95988-21791685@events.umich.edu Event Begins: Thursday, October 6, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Analytical
Long Luo (Wayne State University)

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Other Thu, 06 Oct 2022 18:15:24 -0400 2022-10-06T16:00:00-04:00 2022-10-06T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
TBA (October 7, 2022 12:00pm) https://events.umich.edu/event/97574 97574-21794767@events.umich.edu Event Begins: Friday, October 7, 2022 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

TBA

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Workshop / Seminar Mon, 26 Sep 2022 11:05:01 -0400 2022-10-07T12:00:00-04:00 2022-10-07T13:30:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
Addicted to Salt: Mass Spectrometry Reveals Chlorine Chemistry Degrading Wintertime Air Quality (October 11, 2022 4:00pm) https://events.umich.edu/event/96496 96496-21792592@events.umich.edu Event Begins: Tuesday, October 11, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Chlorine radicals (Cl·) readily react with the greenhouse gas methane and other volatile hydrocarbons, facilitating the production of ozone and particulate matter that degrade air quality and harm human health. An important chlorine source is the photolysis of nitryl chloride (ClNO2(g)), which is formed in the polluted atmosphere at night through the reaction of dinitrogen pentoxide (N2O5(g)) with chloride-containing surfaces. The importance of ClNO2 in marine and coastal locations is well-recognized due to presence of sea spray aerosol. However, ClNO2 was unexpectedly detected in regions far inland from the ocean, with wintertime levels rivaling marine locations. We tackled investigation of this unresolved chemistry through a series of field-based measurements of atmospheric trace gases, individual particles, and snow, complemented by “lab-in-the-field” experiments and modeling, in wintertime urban environments. Our novel single-particle measurements, combined with online ion chromatography, identified road salt aerosol as the dominant chloride source. ClNO2 production from the reaction of N2O5 with road salt aerosol was quantitatively observed by chemical ionization mass spectrometry. We also exposed road salt-contaminated snow to synthesized N2O5 and observed ClNO2 production, discovering yet another unique chloride source in the wintertime inland environment. We showed that ClNO2 produced from the saline snowpack alters air quality even hundreds of meters above the snow-covered ground. Our discovery of the connection between road salt and wintertime air quality has profound implications for wintertime atmospheric chemistry and decision-making regarding deicing practices, as tens of millions of tons of road salt are spread on roadways for deicing globally each winter.


Kerri Pratt

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Other Tue, 11 Oct 2022 18:15:21 -0400 2022-10-11T16:00:00-04:00 2022-10-11T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
USWE x GradSWE Speed Dating (October 11, 2022 6:30pm) https://events.umich.edu/event/99716 99716-21798573@events.umich.edu Event Begins: Tuesday, October 11, 2022 6:30pm
Location: Chemistry Dow Lab
Organized By: Graduate Society of Women Engineers

Come join us for our first ever Undergraduate x Graduate SWE Speed Dating! We will have dinner and snacks while you get to meet other Michigan SWEsters and talk about your experiences with applying to/being in grad school, research, and anything else you wish you had known when you were an undergrad!

RSVP is requested.

Contact Anna Nickel at anickel@umich.edu with any questions.

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Social / Informal Gathering Mon, 03 Oct 2022 01:57:46 -0400 2022-10-11T18:30:00-04:00 2022-10-11T19:30:00-04:00 Chemistry Dow Lab Graduate Society of Women Engineers Social / Informal Gathering GradSWE | University of Michigan
Ab-initio solid state chemistry as a new frontier of theory (October 12, 2022 4:00pm) https://events.umich.edu/event/96497 96497-21792593@events.umich.edu Event Begins: Wednesday, October 12, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The search for new materials is at the core of the technological advancement of our society. While many newly synthesized materials can be analyzed by current quantum chemical techniques, mostly based on the density functional theory (DFT), there is a large number of materials that cannot be treated successfully by existing methodologies. This is mostly due to the presence of strong electron correlation, relativistic effects, and disorder. These materials require a post-DFT description that explicitly includes electron-electron interactions.

In my talk, I will discuss current theoretical challenges in the study of solid state materials and I will describe my group's contributions to the development of post-DFT methods. In the first part, I will present the newest relativistic methodologies for solids. In the second part, I will talk about the treatment of strongly correlated electrons residing in d- and f-orbitals of crystals with transition metals. Finally, I will sketch future directions for computational ab-initio solid state chemistry.


Dominika Zgid

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Other Wed, 12 Oct 2022 18:15:27 -0400 2022-10-12T16:00:00-04:00 2022-10-12T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
TBA (October 13, 2022 4:00pm) https://events.umich.edu/event/94377 94377-21736322@events.umich.edu Event Begins: Thursday, October 13, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Analytical
Mark Schoenfisch

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Other Fri, 09 Sep 2022 12:16:25 -0400 2022-10-13T16:00:00-04:00 2022-10-13T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Novartis Symposium (October 18, 2022 9:00am) https://events.umich.edu/event/94715 94715-21762085@events.umich.edu Event Begins: Tuesday, October 18, 2022 9:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


Peter Seeberger(Max-PLanck Institute for Colloids and Interfaces) , Ellen Sletten(UCLA) , Atwood Cheung

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Other Tue, 18 Oct 2022 18:15:26 -0400 2022-10-18T09:00:00-04:00 2022-10-18T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Physics of cellular proportions (October 21, 2022 12:00pm) https://events.umich.edu/event/97575 97575-21794768@events.umich.edu Event Begins: Friday, October 21, 2022 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Dr. Gulliver noticed 140 years ago that the size of the cell\'s nucleus is proportional to the size of the cell. In the intervening years, similar observations have been made about other, large structures that self-assemble in the cell. This raises a fascinating question: How does the cell, which is micrometers in length, measure its size with nothing more at its disposal than nanometer-sized proteins that diffuse, on occasion bump into each other, and transiently stick together? In this talk I will describe quantitative experiments and related theory that reveal general principles of how cells control the size of their internal structures. The case of self-assembly of actin cables in budding yeast is particularly interesting in this context, as it provides an example of a structure whose size is well matched to the size of the cell. I will describe experiments and theory pertaining to actin cables, and the general principles of cellular self-assembly we are learning from this model system.

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Workshop / Seminar Tue, 18 Oct 2022 14:59:08 -0400 2022-10-21T12:00:00-04:00 2022-10-21T13:30:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
Interconnected: An SLC Pixel Project (October 21, 2022 2:00pm) https://events.umich.edu/event/97903 97903-21795303@events.umich.edu Event Begins: Friday, October 21, 2022 2:00pm
Location: Chemistry Dow Lab
Organized By: Science Learning Center

Beginning in 2019, the SLC partnered with artist and U-M alumnus Doug Jones on an inclusive and collaborative art project involving U-M students and staff. Doug specializes in all-inclusive, collaborative design and invented his PIXEL Technique used in much of his work. Several years ago, Doug worked with the U-M Library on a similar project, Connect the Dots: Collective Interpretations from the U-M Library Collections, from 2018-2019. U-M Library published a video describing that project and Doug's approach. You can also view the online exhibit or see the works in person in the Shapiro Undergraduate and Hatcher Graduate libraries.

This fall, the SLC will unveil the four art pieces created in collaboration with Doug and over 50 U-M student and staff co-creators. The special open house will be revealed as part of the newly renovated Science Learning Center. We have worked closely with our partners in LSA facilities to plan and implement renovations that go beyond aesthetic and infrastructure improvements, but focus on making the physical space more welcoming and inclusive. This artwork will be a critical component of our transformed space.

RSVP required by Friday, October 21 at 12:00 noon.

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Reception / Open House Mon, 17 Oct 2022 10:39:33 -0400 2022-10-21T14:00:00-04:00 2022-10-21T16:00:00-04:00 Chemistry Dow Lab Science Learning Center Reception / Open House Interconnected: An SLC Pixel Project
Synthetic and Catalytic Applications of Halogen Bond (October 25, 2022 11:30am) https://events.umich.edu/event/95564 95564-21790157@events.umich.edu Event Begins: Tuesday, October 25, 2022 11:30am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Organic
Wei Li (University of Toledo)

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Other Tue, 25 Oct 2022 18:15:40 -0400 2022-10-25T11:30:00-04:00 2022-10-25T12:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Bioanalytical Applications of Microchip Electrophoresis (October 27, 2022 4:00pm) https://events.umich.edu/event/84333 84333-21623352@events.umich.edu Event Begins: Thursday, October 27, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Microchip electrophoresis is a powerful tool for the analysis of biological samples. In particular, the ability to perform fast efficient separations makes it possible to monitor several compounds simultaneously with high temporal resolution. The small dimensions of the channels in the chip are compatible with the analysis of microdialysis samples and single cells. In this presentation, two applications of microchip electrophoresis (ME) for biochemical investigations will be presented. The first application involves the development of ME-based methods for the detection of reactive nitrogen and oxygen species (RNOS) in macrophages and microglia. The second involves the combination of microdialysis with microchip electrophoresis for near real-time continuous monitoring of amino acids, catecholamines, and nitric oxide metabolites in awake, freely roaming animals. The goal of this second application is to miniaturize the entire system for simultaneous monitoring of neurochemistry and behavior with on-animal analysis and telemetry control.

Susan Lunte (University of Kansas)

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Other Thu, 27 Oct 2022 18:15:28 -0400 2022-10-27T16:00:00-04:00 2022-10-27T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
How To Stay Motivated To Study (October 31, 2022 11:30am) https://events.umich.edu/event/99624 99624-21798472@events.umich.edu Event Begins: Monday, October 31, 2022 11:30am
Location: Chemistry Dow Lab
Organized By: Women in Science and Engineering (WISE) Program

Are you struggling to keep up with your work? Most of us have trouble staying motivated to keep up with school work after many tough months. Meet WISE at any of our upcoming tabling events to learn more about what our office offers and learn some effective tools to stay motivated.

Monday, 10/31 from 11:30am-1:30pm- Chemistry Atrium
Tuesday, 11/1 from 11:30am-1:30pm- Duderstadt Connector
Wednesday, 11/2 from 11:30am-1:30pm- East Hall South Atrium
Thursday, 11/3 from 11:30am-1:30pm- Robotics Atrium
Friday, 11/4 from 2:30pm-4:40pm- Haven Hall Posting Area

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Well-being Fri, 28 Oct 2022 11:34:21 -0400 2022-10-31T11:30:00-04:00 2022-10-31T13:30:00-04:00 Chemistry Dow Lab Women in Science and Engineering (WISE) Program Well-being woman writing formulas on white board with yellow overlay and event title
Exciton-Coupled Coherent Magnons (October 31, 2022 4:00pm) https://events.umich.edu/event/100825 100825-21800394@events.umich.edu Event Begins: Monday, October 31, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The information generated by qubits is at helium temperature and localized. Magnons that are coupled to qubits and optical photons can shuttle information created by qubits at a long distance and up to room temperature. Two-dimensional magnetic semiconductors are attractive candidates to serve as this magnon medium because they can hold both tightly-bound excitons with large oscillator strength and potentially long-lived coherent magnons due to the presence of bandgap and spatial confinement. In this talk, I will discuss the nature of magnon-exciton coupling in the two-dimensional van der Waals antiferromagnetic semiconductor CrSBr. Then, I will talk about how the exciton-coupled magnons coherently propagate in time and space. Lastly, I will discuss the implication of strong coupling between magnons (0.1 meV) to excitons (1.3 eV), and relatively long coherent propagation length (7 µm) and time (10 ns) in magnonics, quantum information science, and optoelectronics.
Youn Jue (Eunice) Bae (Columbia University)

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Other Mon, 31 Oct 2022 06:15:26 -0400 2022-10-31T16:00:00-04:00 2022-10-31T17:15:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Leveraging Dynamic Properties to Understand Protein (Dys)function in Disease (November 2, 2022 4:00pm) https://events.umich.edu/event/100826 100826-21800395@events.umich.edu Event Begins: Wednesday, November 2, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The dynamical properties of proteins are critical for their function and are often perturbed in disease. Despite this knowledge, developing chemical probes that explicitly target protein dynamics is challenging, and therapeutic molecules that alter protein dynamics are often discovered serendipitously. However, all living organisms contain a dedicated class of proteins, termed molecular chaperones, that specifically regulate protein folding and dynamics to prevent pathological outcomes. Can understanding the function of these molecular chaperone proteins inspire development of novel “pharmacological chaperones”? By combining biochemistry, biophysics, and chemical biology approaches with human genetics and emerging technologies, my research aims to answer this question. Specifically, my goal is to use these molecules to study and correct altered protein dynamics in neurodegenerative and neuromuscular diseases.
Oleta Johnson (UCSF)

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Other Mon, 31 Oct 2022 06:15:27 -0400 2022-11-02T16:00:00-04:00 2022-11-02T17:15:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Engineering nano-bio interfaces for immunity and infection (November 3, 2022 4:00pm) https://events.umich.edu/event/95503 95503-21790015@events.umich.edu Event Begins: Thursday, November 3, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Analytical
Yan Yu (Indiana University)

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Other Thu, 03 Nov 2022 18:15:40 -0400 2022-11-03T16:00:00-04:00 2022-11-03T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Extreme Light-Matter Interactions in Two Dimensions (November 10, 2022 4:00pm) https://events.umich.edu/event/100827 100827-21800396@events.umich.edu Event Begins: Thursday, November 10, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Spectroscopy is a tool for scientists to see quantum states of materials with light. When the field strength of the light approaches the internal Coulomb force of materials, it can be used to control their electronic properties by inducing nonequilibrium quantum states. In this talk, I will discuss the potential of such intense light-matter interactions in novel two-dimensional materials, monolayer transition-metal dichalcogenides (TMDs), with special emphasis on energy state control and extreme nonlinear optics. These experiments are enabled by the development of powerful mid-infrared light sources that can efficiently access internal resonance of electron-hole states, known as excitons, while avoiding sample damage that may result from direct photoabsorption. In the first part of the talk, I will present energy state control of monolayer TMDs beyond the perturbative regime, wherein a light-dressed replica and giant blue shift of excitonic states are characterized. In the second part of the talk, I will demonstrate the unique application of artificially stacked TMDs to realize nonlinear optical processes of high-harmonic generation with enhanced efficiency. These findings demonstrate the exciting opportunities of harnessing quantum dynamics beyond perturbation in novel two-dimensional materials.
Yuki Kobayashi (Stanford PULSE Institute)

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Other Thu, 03 Nov 2022 15:30:24 -0400 2022-11-10T16:00:00-05:00 2022-11-10T17:15:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Divergent Roles of Dicer’s Helicase Domain in Antiviral Defense (November 14, 2022 4:00pm) https://events.umich.edu/event/95716 95716-21790781@events.umich.edu Event Begins: Monday, November 14, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Viruses were once thought to be the sole source of long double-stranded RNA (dsRNA) in animal cells, but the Bass laboratory identified numerous long dsRNAs that are genomically encoded and expressed in animals, including humans. dsRNA-binding proteins enable cells to distinguish the “good” cellular dsRNA from the “bad” viral dsRNA, but how they do this is not completely understood. Our current studies are focused on how a conserved helicase domain distinguishes “self” versus “non-self” dsRNA, and how this function has diverged in vertebrates and invertebrates. We used ancestral sequence reconstruction to infer amino acid sequences of the helicase domain of ancestral Dicers, enabling comparisons of its enzymatic activity with that of modern-day Dicer enzymes.
Brenda Bass

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Other Mon, 14 Nov 2022 18:15:35 -0500 2022-11-14T16:00:00-05:00 2022-11-14T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Prof. Clay Bennett Seminar (November 15, 2022 9:00am) https://events.umich.edu/event/95350 95350-21789213@events.umich.edu Event Begins: Tuesday, November 15, 2022 9:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Organic

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Other Tue, 02 Aug 2022 12:15:19 -0400 2022-11-15T09:00:00-05:00 2022-11-15T17:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Mastering Hierarchical and Non-Equilibrium Materials for Climate and Energy Crisis (November 15, 2022 4:00pm) https://events.umich.edu/event/100828 100828-21800397@events.umich.edu Event Begins: Tuesday, November 15, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The climate crisis is reshaping how we harvest, store, and consume energy globally. To achieve net zero emissions by 2050, we must develop low-cost and energy-efficient materials and mechanisms for carbon capture, hydrogen storage, and sustainable catalysis. In the first part of my talk, I will describe my efforts to develop new hierarchical materials for carbon capture by utilizing framework lability. Synthetic strategies, such as linker deletion and migration, are used to tailor the complex pore environments of metal-organic frameworks for applications in gas storage, separation, and catalysis. In the second part of my talk, I will describe my design of an active adsorption mechanism that provides a potential solution for effective decarbonization. Over the past century, adsorption has been investigated extensively only in equilibrium systems, with a focus on physisorption and chemisorption. I will present the first fundamentally new mode of adsorption—mechanisorption—since the observation of physisorption and chemisorption in the 1930s, which results from non-equilibrium pumping to form mechanical bonds between adsorbents and adsorbates. Analogous to the mechanism in living organisms to control the active transport of ions across membranes, adsorbates are transported from one well-defined compartment—the bulk—to another well-defined compartment—the interface—thereby creating a vast chemical potential gradient commensurate with storing energy in a metastable state. Mechanisorption extends, in a fundamental manner, the scope and potential of adsorption phenomena and offers a transformative approach to control chemistry at surfaces and interfaces. Lastly, I will summarize the progress and provide an outlook for my next steps and future research vision in driving continuous adsorption of carbon dioxide from low-concertation regions, the air, to highly concentrated surfaces through this new active adsorption mechanism.


Liang Feng (Northwestern University)

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Other Mon, 31 Oct 2022 06:15:27 -0400 2022-11-15T16:00:00-05:00 2022-11-15T17:15:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
A Designer's Toolkit for Constructing Complex Nanoparticle Libraries (November 17, 2022 4:00pm) https://events.umich.edu/event/96474 96474-21792566@events.umich.edu Event Begins: Thursday, November 17, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Nanoparticles that contain multiple materials combine different properties in a single construct, enabling both multi-functionality and the emergence of new synergistic functions. Synthesizing such multi-component nanoparticles requires simultaneous control over size, shape, composition, and structure, as well as interfaces and spatial arrangements. We have been developing two complementary strategies for synthesizing multi-component nanoparticles. The first approach involves heterogeneous seeded growth, where interfaces and asymmetry are introduced by sequentially growing new nanoparticles off of the surfaces of existing nanoparticles. Complex hybrid nanoparticles of a growing number of materials, configurations, and morphologies can now be synthesized. The second approach involves sequential partial cation exchange reactions, where interfaces and asymmetry are introduced by compositional modifications that are made within an existing nanoparticle. A growing library of complex heterostructured metal sulfide nanoparticles can now be rationally designed and then readily synthesized.




Raymond Schaak (The Pennsylvania State University)

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Other Thu, 17 Nov 2022 18:15:27 -0500 2022-11-17T16:00:00-05:00 2022-11-17T17:15:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Sir Alex Halliday to give special lecture (November 17, 2022 4:00pm) https://events.umich.edu/event/100975 100975-21800623@events.umich.edu Event Begins: Thursday, November 17, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Earth and Environmental Sciences

We are very excited to have our past faculty colleague Prof. Alex Halliday visiting the University of Michigan on Thursday, Nov. 17th. He is currently the Director of the Earth Institute at Columbia University and Founding Dean of the Columbia Climate School.

When Alex was at Michigan (1986-1998), he performed the first isotopic measurements that constrained the timing of Earth’s core formation and made the link to the giant impact event that formed our Moon. In 2000, he coined the term “Theia” for the Mars-sized impactor that struck the Earth early in its history. Alex has continued his research into Earth’s origins and will be giving a talk on this subject on Thursday, Nov. 17th at 4:00 p.m. in 1400 Chemistry Building. It is entitled, “New uncertainties around Earth’s origins”.

Alex has received numerous honors and awards in recognition of his scientific contributions. These include the Bowen Award and Hess Medal from the American Geophysical Union, the Urey Medal of the European Association of Geochemistry, among others. He is an elected Fellow of the Royal Society (FRS) and a Foreign Associate of the National Academy of Sciences (NAS).

Alex is a superb speaker and has a compelling scientific story to tell – please encourage all of the graduate students, postdocs and research scientists in your group (irrespective of your sub-fields) to come to his talk!

ALSO: Alex will be hosting a round-table Q&A (refreshments will be provided) on the Climate School at Columbia University. For everyone in your research group (and students in your classes) who are interested in climate-related research and initiatives, please attend! All are welcome! It will be held in Room 2540 from 2:00-3:15 p.m. in North University Building.

Thanks to all for spreading the word (and for making every effort to attend his lecture)!!!

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Lecture / Discussion Fri, 11 Nov 2022 10:27:48 -0500 2022-11-17T16:00:00-05:00 2022-11-17T17:00:00-05:00 Chemistry Dow Lab Earth and Environmental Sciences Lecture / Discussion Alex Halliday will give a lecture on November 17 at 4pm.
From Stereocontrolled Glycosylation to Early-Stage Automation: Adventures in Deoxy Sugar Oligosaccharide Synthesis (November 22, 2022 11:30am) https://events.umich.edu/event/96449 96449-21792543@events.umich.edu Event Begins: Tuesday, November 22, 2022 11:30am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Organic
Clay Bennett (Tufts University)

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Other Tue, 22 Nov 2022 18:15:21 -0500 2022-11-22T11:30:00-05:00 2022-11-22T12:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Controlling Darwinian evolution to discover functional molecules and mechanisms (November 29, 2022 4:00pm) https://events.umich.edu/event/95530 95530-21790078@events.umich.edu Event Begins: Tuesday, November 29, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Chembio
Bryan Dickinson (UChicago)

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Other Tue, 29 Nov 2022 18:15:24 -0500 2022-11-29T16:00:00-05:00 2022-11-29T17:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Structure Determination of Inorganic Materials and Heterogeneous Catalysts by Sensitivity-Enhanced Solid-State NMR Spectroscopy (December 1, 2022 4:00pm) https://events.umich.edu/event/101655 101655-21802188@events.umich.edu Event Begins: Thursday, December 1, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Physical
Aaron Rossini (Iowa State University)

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Other Thu, 01 Dec 2022 18:15:57 -0500 2022-12-01T16:00:00-05:00 2022-12-01T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
From intra- to inter- generational scaling laws governing long-term stochastic individual cell dynamics (December 2, 2022 12:00pm) https://events.umich.edu/event/101771 101771-21802336@events.umich.edu Event Begins: Friday, December 2, 2022 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Over 150 years since Claude Bernard coined the evocative phrase, “milieu intérieur”, to draw attention to a deep mystery in the natural world, fundamental questions remain open about how the simplest living system, a bacterial cell, maintains homeostasis of its best studied attribute, cell size. In this talk I will address how life shapes time in a bacterial cell, and examine the interplay between homeostasis and adaptation in this context. First, I will first establish that stochastic intergenerational bacterial cell homeostasis_is_ maintained under appropriate growth conditions, using our precision measurements. Next, the emergent simplicities revealed by these data. Following this, a fitting-free theoretical framework, consistent with observed scaling laws and phenomenology. This naturally leads to a proposal for the underlying mechanistic model. Finally, the extension to time-varying growth conditions, and new emergent simplicities

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Workshop / Seminar Thu, 01 Dec 2022 09:37:37 -0500 2022-12-02T12:00:00-05:00 2022-12-02T13:30:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
Electrocatalysis Using Main-Group-Element-based Molecular Catalysts (December 6, 2022 4:00pm) https://events.umich.edu/event/96444 96444-21792541@events.umich.edu Event Begins: Tuesday, December 6, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Inorganic
Jianbing Jiang (University of Cincinatti)

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Other Tue, 06 Dec 2022 18:15:20 -0500 2022-12-06T16:00:00-05:00 2022-12-06T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Exploiting Chemical Modifications for Structural Elucidation by Mass Spectrometry (January 12, 2023 4:00pm) https://events.umich.edu/event/96129 96129-21791947@events.umich.edu Event Begins: Thursday, January 12, 2023 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

TBD
Ian Webb (IUPUI)

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Other Thu, 12 Jan 2023 18:15:14 -0500 2023-01-12T16:00:00-05:00 2023-01-12T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
TBA (January 13, 2023 12:00pm) https://events.umich.edu/event/102714 102714-21805028@events.umich.edu Event Begins: Friday, January 13, 2023 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

TBA

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Workshop / Seminar Tue, 03 Jan 2023 15:09:19 -0500 2023-01-13T12:00:00-05:00 2023-01-13T13:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
Physical Chemistry 3rd Year Seminars (January 19, 2023 4:00pm) https://events.umich.edu/event/100320 100320-21799603@events.umich.edu Event Begins: Thursday, January 19, 2023 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Physical
Ryan Lamb, David Fuller

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Other Thu, 19 Jan 2023 18:15:11 -0500 2023-01-19T16:00:00-05:00 2023-01-19T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
"From genes to geometry: organ morphogenesis via calcium-patterned muscle constrictions" (January 23, 2023 12:00pm) https://events.umich.edu/event/103545 103545-21807456@events.umich.edu Event Begins: Monday, January 23, 2023 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

ABSTRACT: During embryonic development, organs fold into complex shapes that are vital for function. Specific genes are known to regulate organ form, but the mechanical programs by which organ tissues sculpt themselves into shape remain mysterious. Here, we trace the dynamics and mechanical interactions driving inner organ shape change using the embryonic midgut of the fly Drosophila melanogaster. By leveraging deep-tissue light-sheet microscopy for whole-organ live imaging and building a computational framework for extracting tissue deformations in dynamic 3D geometries, we find a mechanical program folding the gut. Hox genes control the emergence of high-frequency calcium pulses, which trigger muscle contractions. These contractions, in turn, induce cell shape change in the adjacent tissue layer, collectively driving a pattern of in-plane tissue deformations. As seen in a simple model, this in-plane pattern is linked to out-of-plane organ folding. These findings offer a mechanical route for gene expression to induce organ shape change: genetic patterning in one layer triggers a physical process to fold the organ into chambers.

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Workshop / Seminar Tue, 17 Jan 2023 14:26:17 -0500 2023-01-23T12:00:00-05:00 2023-01-23T13:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Noah Mitchell
Well-Defined Nanocrystal Surfaces and Interfaces for Electrocatalysis (January 26, 2023 4:00pm) https://events.umich.edu/event/96475 96475-21792567@events.umich.edu Event Begins: Thursday, January 26, 2023 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Crucial to sustainable energy future is the ability to manipulate important chemical reactions for the production and conversion of clean hydrogen (H2) fuel and renewable carbon-based chemicals through the development of advanced catalysts. Well-defined nanocrystals with atomically precise surfaces and interfaces allow us to bridge the knowledge gap between conventional single-crystal bulk materials and powder catalysts to achieve a new and in-depth understanding of structure-catalytic property relationships. In this talk, I will highlight how nanocrystal catalyst surfaces and interfaces can be synthetically tuned with atomic precision for the improved performance in the oxygen-mediated energy conversion reactions: the oxygen reduction reaction (ORR) for fuel cells and the oxygen evolution reaction (OER) for water electrolyzer. The first nanocrystal system I will discuss is the M-Pt (M=non-precious metals) core-shell nanocrystals within which desirable/undesirable interfaces between non-precious metal M core and precious metal Pt shell were identified by theoretical calculations and were experimentally balanced through wet-chemical synthesis. The optimized core-shell nanocrystals exhibited favorable interfacial interaction through properly coupled electronic and strain effects, leading to an enhanced electrocatalytic efficiency towards the ORR. In the second system, we elucidated and modulated the interaction of single-site Co, Fe, Ni catalytic centers and inorganic coordination environments in the surface of doped metal oxide nanocrystals for the OER. The seamless integration of controlled synthesis of nanocrystals, operando structural/catalytic characterization, and advanced theoretical calculation for oxygen electrocatalyst development will be discussed, which will also be extended to other electrocatalytic (e.g., CO2 reduction and biomass-derived molecule upgrading) and thermocatalytic processes (e.g., CO2 hydrogenation).






Sen Zhang (University of Virginia)

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Other Thu, 26 Jan 2023 18:15:18 -0500 2023-01-26T16:00:00-05:00 2023-01-26T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Physical Chemistry 3rd Year Seminars (February 2, 2023 4:00pm) https://events.umich.edu/event/100321 100321-21799604@events.umich.edu Event Begins: Thursday, February 2, 2023 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Physical
Yekaterina Fyodorova, Sam McCalpin

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Other Thu, 02 Feb 2023 18:15:10 -0500 2023-02-02T16:00:00-05:00 2023-02-02T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
"From genes to geometry: organ morphogenesis via calcium-patterned muscle constrictions“ (February 6, 2023 12:00pm) https://events.umich.edu/event/104300 104300-21808804@events.umich.edu Event Begins: Monday, February 6, 2023 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

During embryonic development, organs fold into complex shapes that are vital for function. Specific genes are known to regulate organ form, but the mechanical programs by which organ tissues sculpt themselves into shape remain mysterious. Here, we trace the dynamics and mechanical interactions driving inner organ shape change using the embryonic midgut of the fly Drosophila melanogaster. By leveraging deep-tissue light-sheet microscopy for whole-organ live imaging and building a computational framework for extracting tissue deformations in dynamic 3D geometries, we find a mechanical program folding the gut. Hox genes control the emergence of high-frequency calcium pulses, which trigger muscle contractions. These contractions, in turn, induce cell shape change in the adjacent tissue layer, collectively driving a pattern of in-plane tissue deformations. As seen in a simple model, this in-plane pattern is linked to out-of-plane organ folding. These findings offer a mechanical route for gene expression to induce organ shape change: genetic patterning in one layer triggers a physical process to fold the organ into chambers.

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Workshop / Seminar Tue, 31 Jan 2023 13:38:38 -0500 2023-02-06T12:00:00-05:00 2023-02-06T13:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Noah Mitchell
DNA Nanostructures: From Design to Biological Function (February 7, 2023 4:00pm) https://events.umich.edu/event/104281 104281-21808781@events.umich.edu Event Begins: Tuesday, February 7, 2023 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Chembio
Hanadi Sleiman

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Other Tue, 07 Feb 2023 18:15:13 -0500 2023-02-07T16:00:00-05:00 2023-02-07T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Physical Chemistry 3rd Year Seminars (February 9, 2023 4:00pm) https://events.umich.edu/event/100355 100355-21799657@events.umich.edu Event Begins: Thursday, February 9, 2023 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Physical
Meghan Orr, Ziqiao Xu

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Other Thu, 09 Feb 2023 18:15:11 -0500 2023-02-09T16:00:00-05:00 2023-02-09T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Synthetic Cluster Models of Inorganic and Organometallic Active Sites in Proteins (February 14, 2023 4:00pm) https://events.umich.edu/event/104359 104359-21808862@events.umich.edu Event Begins: Tuesday, February 14, 2023 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Complex inorganic active sites perform challenging catalytic transformations in biological systems, such as water oxidation by Photosystem II and nitrogen reduction in Nitrogenase. The effect of cluster structure on the physical and chemical properties of these active sites is not well understood. We have developed methodologies for the rational synthesis of tetranuclear homo- and hetero-metallic cluster models of protein active sites, which allow for systematic structure-property studies. Distal redox changes have been demonstrated to have a substantial effect on the reactivity and binding of ligands relevant to small molecule conversions. Upon incorporation of second coordination sphere hydrogen bonding interactions, water oxidation catalysis was observed. Spectroscopic studies of models with structures or redox states relevant to the protein active site provide benchmarking for the biological system. Implications for function and spectroscopy will be discussed.








Theo Agapie (Caltech)

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Other Tue, 14 Feb 2023 18:15:13 -0500 2023-02-14T16:00:00-05:00 2023-02-14T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Getting to the Heart of the Matter: Pre-Health Personal Statement Workshop (February 15, 2023 12:00pm) https://events.umich.edu/event/102497 102497-21804135@events.umich.edu Event Begins: Wednesday, February 15, 2023 12:00pm
Location: Chemistry Dow Lab
Organized By: Newnan LSA Pre-Health

An effective personal statement lives at the heart of your medical or professional health school application. Your personal statement allows you to tell your story to an admissions committee and share who you are and why you make a wonderful addition to a medical or health professions program. This workshop focuses on how you can get started writing a winning statement. You will learn how to focus on the passions, values, relationships, community service, clinical work, and other life experiences which led to your interest in health care. This workshop is designed to get you writing and reflecting on the story you want to tell on your application. Come to the workshop ready for getting started on an early draft.

Please register for this event on sessions: https://sessions.studentlife.umich.edu/track/event/12661

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Workshop / Seminar Wed, 21 Dec 2022 17:24:54 -0500 2023-02-15T12:00:00-05:00 2023-02-15T13:00:00-05:00 Chemistry Dow Lab Newnan LSA Pre-Health Workshop / Seminar Simple stethoscope on a pastel blue background.
Probing and Controlling the Dynamics of Photochromic Molecules (February 16, 2023 4:00pm) https://events.umich.edu/event/97041 97041-21793743@events.umich.edu Event Begins: Thursday, February 16, 2023 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Photochromic molecular switches are compounds that change color upon optical excitation. The color change is a response to the making, breaking, and rearranging of bonds in the molecule. We use ultrafast spectroscopy to probe changes in the molecular structure and to reveal new information about the fundamental reaction dynamics of molecules in solution. In particular, we examine the dynamics of molecules in highly excited electronic states (above S1). We use both transient absorption and resonance Raman measurements to monitor the dynamics of molecules that are excited using a pair of time-delayed laser pulses. Beyond simply watching the reaction unfold, sequential excitation with two independent photons allows us to control the dynamics of the molecule and influence the outcome of the reaction. For example, selectively varying the relative time delay and wavelength for secondary excitation allows the molecule to sample different reaction channels. These experiments probe the potential energy surfaces that determine the motions of the atoms and provide unique insight on the dynamics of molecules in highly excited electronic states, an important frontier in chemical reaction dynamics.


Chris Elles (University of Kansas)

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Other Thu, 16 Feb 2023 18:15:11 -0500 2023-02-16T16:00:00-05:00 2023-02-16T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Science Success Series | Canvas Course Launch Event (February 17, 2023 3:00pm) https://events.umich.edu/event/104447 104447-21809065@events.umich.edu Event Begins: Friday, February 17, 2023 3:00pm
Location: Chemistry Dow Lab
Organized By: Science Learning Center

Are you interested in shifting your mindset? Would you like to discover new learning strategies? Interested in learning about medical school? Want to learn about career and professional opportunities? If you answered yes to any of these questions, please come to this event to learn about the “Science Success Series” Canvas course. This is a non-credit bearing, self-enroll course that enables you to explore these areas at your own pace. This drop- in event where you can come and go as your schedule allows. Light snacks and refreshments will be provided.

Register on Sessions: https://myumi.ch/EPkMp

Email ScienceSuccessSeries@umich.edu with any questions.

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Workshop / Seminar Thu, 02 Feb 2023 15:44:31 -0500 2023-02-17T15:00:00-05:00 2023-02-17T16:30:00-05:00 Chemistry Dow Lab Science Learning Center Workshop / Seminar Science Success Series Canvas course header image
Light-driven Fuel Production mediated by Molecular Catalysts (February 21, 2023 4:00pm) https://events.umich.edu/event/96643 96643-21792971@events.umich.edu Event Begins: Tuesday, February 21, 2023 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Using solar photons to drive energy intensive reactions that take energy poor feedstocks like water and carbon dioxide into energy rich fuels represents an opportunity to capture and store diffuse solar energy. Molecular catalysts can selectively mediate the multi-electron, multi-proton transformations that convert water and carbon dioxide into energy rich fuels but practical technologies that integrate these complexes with light absorbers have yet to be realized. To address the challenges limiting the development of solar fuel technologies, my research lab is learning (1) how to exploit energy-efficient proton-coupled electron transfer (PCET) processes for fuel production schemes and (2) how to integrate fuel-producing catalysts with photon capturing materials. Through this work, new approaches to efficiently convert solar photons into chemical energy are being developed. \r\n \r\n






Jillian Dempsey (University of North Carolina)

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Other Tue, 21 Feb 2023 18:15:09 -0500 2023-02-21T16:00:00-05:00 2023-02-21T17:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Physical Chemistry 3rd Year Seminars (February 23, 2023 4:00pm) https://events.umich.edu/event/100322 100322-21799605@events.umich.edu Event Begins: Thursday, February 23, 2023 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Physical

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Other Fri, 28 Oct 2022 06:15:29 -0400 2023-02-23T16:00:00-05:00 2023-02-23T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
"It Takes Two: Conserved bimodal interactions between the coronavirus fusion peptide and calcium ions promote host membrane insertion and viral entry" (February 24, 2023 12:00pm) https://events.umich.edu/event/104219 104219-21808682@events.umich.edu Event Begins: Friday, February 24, 2023 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

The coronavirus disease 2019 (COVID-19) necessitates develop of effective therapies against the causative agent, SARS-CoV-2, and other pathogenic coronaviruses (CoV) that have yet to emerge. Focusing on the CoV replication cycle, specifically the entry steps involving membrane fusion, is an astute choice because of the conservation of the fusion machinery and mechanism across the CoV family. For coronavirus, entry into a host cell is mediated by a single glycoprotein protruding from its membrane envelope, called spike (S). Within S, the region that directly interacts with the membrane is called the fusion peptide, FP. It is the physico-chemical interactions of the FP with the host membrane that anchors it, enabling the necessary deformations of the membrane leading to delivery of the viral genome into the cell when a fusion pore opens. Thermodynamic, kinetic, and intermolecular interac-tions are useful to understand molecular level FP interactions with the host membrane. This knowledge can be leveraged to stop the spread of infection. Here, we examine the impact of calcium ions on CoV entry. Using cell infectivity, biophysical assays, and spectroscopic methods, we found that calcium ions stabilize the FP structure during conformational change that then allows its insertion into the host membrane, resulting in increased lipid ordering in the membrane. This lipid ordering precedes mem-brane fusion and correlates with increased fusion activity and higher levels of infection when calcium in present. As such, depletion of calcium ions leads to structure and activity changes in the fusion peptide that correlate well with in vitro experiments using calcium-chelating agents to block cell infection. We show calcium channel blockers can block virus infection in lung cells.

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Workshop / Seminar Mon, 30 Jan 2023 12:26:25 -0500 2023-02-24T12:00:00-05:00 2023-02-24T13:30:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Susan Daniel
The multi-dimensionality of microplastics – and how it affects their fate and effects in aquatic ecosystems (February 28, 2023 4:00pm) https://events.umich.edu/event/95919 95919-21791435@events.umich.edu Event Begins: Tuesday, February 28, 2023 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Microplastic particles are unique from other contaminants in that they are a physical particle composed of a complex mixture of different chemicals (e.g., monomers, additives). In the environment, they are found in diverse shapes and sizes. These multidimensional characteristics affect their fate in the environment, and thus exposure in biota. Moreover, their different characteristics likely affect their impact on ecosystems. This presentation will share results from an in-lake mesocosm experiment conducted at the International Institute for Sustainable Development’s Experimental Lakes Area (IISD-ELA) to discuss the fate of microplastics in aquatic ecosystems. Different concentrations of a mixture of polyethylene, polystyrene and polyethylene terephthalate were added to nine 10-m diameter x 2-m deep limnocorrals as part of a ten-week experiment to measure the fate and effects of microplastics. The fate of the microplastics influences exposure in biota – relevant to risk. In addition to discussing the work at IISD-ELA, this presentation will share results from meta-analyses, and field and lab experiments to discuss the fate of microplastics in food webs and the physical and chemical effects of different types of microplastics across multiple levels of biological organization. Over the last two decades, the field has matured and we are beginning to understand the contamination, fate and effects of microplastics. Still, there is a lot to learn about how their diverse characteristics affect their fate and interactions in ecosystems. \r\n




Chelsea Rochman (U-Toronto)

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Other Tue, 28 Feb 2023 18:15:11 -0500 2023-02-28T16:00:00-05:00 2023-02-28T17:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Enhanced Vibrational Spectroscopy – The Surface is Everything (March 9, 2023 4:00pm) https://events.umich.edu/event/97042 97042-21793744@events.umich.edu Event Begins: Thursday, March 9, 2023 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Surface-sensitive vibrational spectroscopic techniques rely on molecular interactions with relevant interfaces. For instance, surface-enhanced Raman scattering (SERS) requires that molecules interact with the metal surface at short distances of 2 nm or less without disrupting the surface atoms. In this presentation, anisotropic nanostructures such as gold nanostars will be used in conjunction with SERS to detect trace molecules. Two challenges and approaches to better predict structure-function behavior of noble metal nanoparticles will be discussed. A combination of experimental measurements that provide molecular-level insight coupled with semi-empirical modeling will be shown to improve the systematic use of gold nanostars by providing a method for predicting the stability and hence, the fate of nanomaterials in various environmental conditions. After these considerations, localized surface plasmon resonance (LSPR) spectroscopy and SERS will be exploited for the direct, qualitative and quantitative detection of small biologically relevant molecules. In the future, these results could be expanded for different nanomaterial shapes, compositions, and molecular targets.
Amanda Haes (University of Iowa)

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Other Thu, 09 Mar 2023 18:15:10 -0500 2023-03-09T16:00:00-05:00 2023-03-09T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Accelerating Drug Discovery: Innovations in Catalysis and High-Throughput Experimentation (March 13, 2023 4:00pm) https://events.umich.edu/event/105372 105372-21811623@events.umich.edu Event Begins: Monday, March 13, 2023 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Organic
Dipannita Kalyani (Merck)

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Other Mon, 13 Mar 2023 18:15:10 -0400 2023-03-13T16:00:00-04:00 2023-03-13T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Unconventional Site Selectivity in Cross-Couplings of Dihaloheteroarenes (March 14, 2023 11:30am) https://events.umich.edu/event/95717 95717-21790782@events.umich.edu Event Begins: Tuesday, March 14, 2023 11:30am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Heteroarenes are ubiquitous motifs in high-value small molecules including pharmaceutical drugs and agrichemicals. Elaboration of halogenated heteroaromatic cores can be achieved through cross-coupling reactions, which are among the most widely used methods in organic synthesis. However, when two or more halides are present on the substrate, controlling site selectivity becomes critical. In fact, cross-couplings often follow a predictable selectivity pattern. For many dihalogenated heteroarenes, methods do not exist to reliably invert the conventional pattern to achieve cross-coupling at the \"less reactive\" C—X bond. Herein we describe new catalyst-controlled strategies to accomplish this goal, together with mechanistic studies to explain the origin of the selectivity inversion.


Sharon Neufeldt (Montana State University)

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Other Tue, 14 Mar 2023 18:15:10 -0400 2023-03-14T11:30:00-04:00 2023-03-14T13:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
3rd Year Materials Student Seminars (March 15, 2023 4:00pm) https://events.umich.edu/event/105060 105060-21810656@events.umich.edu Event Begins: Wednesday, March 15, 2023 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Materials

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Other Wed, 15 Mar 2023 18:15:12 -0400 2023-03-15T16:00:00-04:00 2023-03-15T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
New Strategies for Carbonyl-Olefin Metathesis (March 20, 2023 4:00pm) https://events.umich.edu/event/97085 97085-21793864@events.umich.edu Event Begins: Monday, March 20, 2023 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

FeCl3 has been identified as an earth abundant, environmentally friendly Lewis acid catalyst for ring-closing carbonyl-olefin metathesis. Lewis acid activation is used to promote the formation and fragmentation of oxetane intermediates, avoiding catalytically inactive metal-oxo species and allowing for catalytic turnover. Subsequent efforts led to the discovery of interrupted carbonyl-olefin metathesis as a divergent reaction pathway that operates via oxygen atom transfer. TfOH catalyzes the formation of uniquely substituted fluorene scaffolds from readily accessible substrates. Unlike the inert metal-oxo byproducts of previously reported approaches for carbonyl-olefin metathesis, a new ruthenium alkylidene-mediated hydrazone/oxime-olefin metathesis is developed that forms a highly reactive Ru nitride as the metal byproduct. The high reactivity of this species could be exploited to regenerate a Ru alkylidene, potentially permitting Ru-catalyzed hydrazine/oxime-olefin metathesis as a new approach for catalytic carbonyl-olefin metathesis. \r\n \r\n




Jacob Ludwig (AbbVie)

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Other Mon, 20 Mar 2023 18:15:16 -0400 2023-03-20T16:00:00-04:00 2023-03-20T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
AbbVie Symposium (March 21, 2023 11:45am) https://events.umich.edu/event/104756 104756-21810085@events.umich.edu Event Begins: Tuesday, March 21, 2023 11:45am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Cystic fibrosis is a debilitating genetic disease resulting from mutations in the cystic fibrosis transmembrane conductance regulator (CFTR), an anion channel that modulates epithelial hydration of the lungs and other organs. Treatment of this disease relies on the use of combinations of potentiator drugs which restore function to inactivated receptors and small molecule correctors that stabilize defective proteins to enable normal trafficking and prevent degradation. We have investigated a series of trisubstituted cyclopropanes that show promise as CFTR correctors. Rhodium-catalyzed reactions of donor-acceptor carbenes represent the most general approach to these stereochemically complex structures, however we encountered limitations with the existing methods when applied to heteroaryl substrates that led us to further investigate these reactions. Through a collaborative academic-industry partnership with Prof. Huw Davies lab at Emory University, we discovered surprising new conditions that enable highly enantioselective cyclopropanation reactions for a broad scope of heterocyclic substrates. The seminar will describe the discovery of a novel class of CFTR correctors and the new synthetic methods that were developed and applied to their stereoselective synthesis.
Mike Schrimpf (AbbVie)

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Other Tue, 21 Mar 2023 18:15:10 -0400 2023-03-21T11:45:00-04:00 2023-03-21T13:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Non-Covalent Approaches to Asymmetric Catalysis with Free Radicals (March 21, 2023 4:00pm) https://events.umich.edu/event/95989 95989-21791686@events.umich.edu Event Begins: Tuesday, March 21, 2023 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The applications of free radical intermediates in organic synthesis have expanded significantly in recent years. However, catalytic strategies that enable control of enantioselectivity in radical reactions remain rare. In this lecture, I will describe three recent projects that all make use of attractive non-covalent associations between free radicals (or radical ions) and chiral catalysts as a basis for stereocontrol. Mechanistic and computational efforts to elucidate the precise radical-molecule interactions responsible for asymmetric induction will be presented.


Robert Knowles (Princeton University)

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Other Tue, 21 Mar 2023 18:15:10 -0400 2023-03-21T16:00:00-04:00 2023-03-21T17:15:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Single Atom Logic for Skeletal Editing (March 22, 2023 4:00pm) https://events.umich.edu/event/105819 105819-21813015@events.umich.edu Event Begins: Wednesday, March 22, 2023 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Reactions which can manipulate the connectivity of the molecular skeleton are
underexplored as tools for late-stage functionalization, in part because their
implementation has been hindered by their often nonintuitive retrosynthetic logic. This
presentation will cover selected transformations discovered in our laboratory which
address this challenge by enabling single-atom changes to aliphatic and aromatic
systems through the insertion and deletion of single heavy atoms (C,N,O, etc.), as well
as more complex manipulations leveraging combinations of these elementary
transformations. Our approach to this problem is modality-agnostic, drawing from a
wide range of reactive species and synthetic disciplines (organometallic chemistry,
reagent design, photochemistry). Applications to late-stage functionalization and
diversification of complex pharmaceutically relevant compounds as well as unique
opportunities for synthesis will be presented alongside mechanistic findings.
Mark Levin (University of Chicago)

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Other Wed, 22 Mar 2023 18:15:14 -0400 2023-03-22T16:00:00-04:00 2023-03-22T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Science Success Series | Ace Your Courses: Metacognition is Key! (March 24, 2023 3:30pm) https://events.umich.edu/event/104416 104416-21809040@events.umich.edu Event Begins: Friday, March 24, 2023 3:30pm
Location: Chemistry Dow Lab
Organized By: Science Learning Center

Have you ever found yourself putting forth a great deal of effort into your courses, but not feeling like you are actually learning or are left unsatisfied with your grade? This workshop, based on the work of Dr. Saundra Yancy McGuire, will enable you to analyze your current learning strategies, understand exactly what changes you need to implement to earn an A in your courses, identify concrete strategies to use during the remainder of your semester, and become a more efficient learner.

Register on Sessions: https://myumi.ch/73eNr

Email ScienceSuccessSeries@umich.edu with any questions.

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Workshop / Seminar Thu, 02 Feb 2023 11:52:18 -0500 2023-03-24T15:30:00-04:00 2023-03-24T17:00:00-04:00 Chemistry Dow Lab Science Learning Center Workshop / Seminar Book cover of "Teach Yourself How to Learn" by Saundra Yancy McGuire
Science Success Series | Study Break (March 28, 2023 12:00pm) https://events.umich.edu/event/105794 105794-21812957@events.umich.edu Event Begins: Tuesday, March 28, 2023 12:00pm
Location: Chemistry Dow Lab
Organized By: Science Learning Center

Give your brain a moment to rest by taking a study break! Come join us for an hour of connection and conversation with fellow students while coloring. This is a drop-in style event where you can come and go as your schedule allows.

Register on Sessions: https://myumi.ch/p7dpD

Email ScienceSuccessSeries@umich.edu with any questions.

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Well-being Mon, 06 Mar 2023 11:45:01 -0500 2023-03-28T12:00:00-04:00 2023-03-28T13:00:00-04:00 Chemistry Dow Lab Science Learning Center Well-being Mountain scene coloring page with the phrase "Create your own calm"
“Structure-Based Insights into the Control of Heme Biosynthesis” (March 31, 2023 12:00pm) https://events.umich.edu/event/106128 106128-21813788@events.umich.edu Event Begins: Friday, March 31, 2023 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

ABSTRACT: Heme is a critical biomolecule that carries out several functions in nearly all life forms, including humans where its most widely known role is mediating oxygen transport in the blood. It is imperative that heme production is tightly controlled as alterations in cellular heme levels can have drastic consequences for human health. The first and rate-limiting enzyme controlling heme biosynthesis is aminolevulinic acid synthase (ALAS). ALAS is conserved in α- proteobacteria and non-plant eukaryotes, however, an important structural feature found exclusively in eukaryotic ALAS enzymes is the C-terminal extension. We seek to understand how ALAS interacts with accessory proteins as well as organism-specific differences in protein assembly that may alter the regulation of heme production. Therefore, we use X-ray crystallography combined with biophysical and biochemical characterization of various eukaryotic ALAS enzymes to parse apart the role of this key regulatory region in eukaryote ALAS function. Our work is beginning to reveal key structure-function relationships between the orientation and molecular contacts mediated by the C-terminus and ALAS enzyme function, thus controlling heme biosynthesis.

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Workshop / Seminar Mon, 13 Mar 2023 14:41:10 -0400 2023-03-31T12:00:00-04:00 2023-03-31T13:30:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Dr. Breann Brown
A Radical Approach to Organic Chemistry (April 4, 2023 11:30am) https://events.umich.edu/event/105905 105905-21813248@events.umich.edu Event Begins: Tuesday, April 4, 2023 11:30am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Synthetic chemists need ever better tools to synthesize the molecules of modern life, from life-changing pharmaceuticals to next generation materials. Further, there is increasing need for these transformations to be both step and atom efficient and sustainable, proceeding under mild conditions using earth abundant elements. Here we show how employing open shell intermediates strategically allows for challenging transformations to be achieved directly, from alkene difunctionalization to carboxylic acid deletion. Importantly, these reactions make use of earth abundant elements and proceed under mild conditions, with many being driven by light. Together, our studies demonstrate the versatility of radical reactions to achieve challenging disconnections that are sustainable and environmentally-responsible.


Julian West (Rice University)

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Other Tue, 04 Apr 2023 18:15:14 -0400 2023-04-04T11:30:00-04:00 2023-04-04T13:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Photophysics of Photocatalytic and Radical Systems (April 5, 2023 4:00pm) https://events.umich.edu/event/105995 105995-21813535@events.umich.edu Event Begins: Wednesday, April 5, 2023 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Photoredox catalysis has enabled researchers to overcome previously intractable problems in organic synthesis. The use of light to drive catalysis has allowed for more selective reactions that generate both simple and complex molecules from renewable and economical starting materials under mild conditions. The dynamics of these catalysts following photoexcitation determines their efficiency. A direct time-resolved photophysical view of reactions is essential to construct the full kinetic scheme, observe the intermediates, and thereby link dynamics to structure. Through the use of ultrafast broadband transient absorption and two-dimensional electronic spectroscopy across a wide range of time and energy scales, the Huxter group studies photoinduced single-electron transfer and electronic dynamics in photoredox catalytic and radical systems. These studies have revealed complex mechanisms of photoredox catalytic reactions, including the involvement of reduced solvent as intermediates, multiple photoproducts as well as many productive and unproductive pathways. The study of transition metal complexes has also opened new possibilities for versatile reactive pathways. In this talk, we will present our latest research on a novel series of tripyrrindione molecules, which possess tunable redox-active chemistry. Using ultrafast nonlinear spectroscopy, we explore the dynamics of these molecules and how they are influenced by hydrogen-bonding interactions with the solvent, reversible antiferromagnetic coupling and by the oxidation states of the metal centers. The results of these studies will highlight the potential of tripyrrindione molecules for new redox-active chemistry, catalytic applications, and optical sensing.


Vanessa Huxter (University of Arizona)

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Other Fri, 31 Mar 2023 12:15:11 -0400 2023-04-05T16:00:00-04:00 2023-04-05T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Immunomodulation studies made using nanoparticles and small molecules delivered in vitro and in vivo: examples using lipid nanoparticles as well as chitosan micelles in cancer models (April 6, 2023 4:00pm) https://events.umich.edu/event/97043 97043-21793745@events.umich.edu Event Begins: Thursday, April 6, 2023 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The widespread use of lipid nanoparticles (LNPs) for vaccines during the pandemic has advanced them to become arguably the leading nanomedicine technology. LNPs offer a way to deliver a concentrated payload. If delivered systemically, the LNPs also protect the nucleic acids from nucleases. The rules around their preparation and mechanisms for delivery to cells and endosomal release are still in development. The seminar will describe LNP integration into a high throughput experiment to screen in vitro for immunogenic cell death interactions between microphages and target cancer cells. The development of bright, Raman-active, liposomal NP labels for flow cytometry and chitosan-based radioactive labeling experiments for in vivo non-invasive hepatocyte function assessment will also be presented.


Gilbert Walker (University of Toronto)

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Other Thu, 06 Apr 2023 18:15:12 -0400 2023-04-06T16:00:00-04:00 2023-04-06T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Synthesis and Characterization of Energetic Materials for Explosive and Propellant Applications (April 10, 2023 4:00pm) https://events.umich.edu/event/103557 103557-21807469@events.umich.edu Event Begins: Monday, April 10, 2023 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The development of high-energy-density materials (HEDMs) with high performance and reasonable sensitivity to impact and friction is an overarching goal in the field of energetic materials. Two areas of interest in our HEDM research are the synthesis of high-energy melt-castable explosives to replace TNT and the synthesis of high-energy propellant plasticizers to replace inert ingredients. Meaningful properties of melt-castable explosives include a melting point range of 70-120 °C, a low vapor pressure, a significant difference between the melting temperature and the decomposition temperature, high density, low sensitivity, an affordable synthesis, and a detonation velocity and detonation pressure that significantly outperforms 2,4,6-trinitrotoluene (TNT).
A plasticizer enhances fluidity or plasticity when added to a rocket or gun propellant formulation. Energetic plasticizers are used to improve physical properties, to act as a fuel, and to improve the overall energy yield of a formulation. In designing an optimal plasticizer, understanding how chemical functional groups affect the melting point, freezing point, and decomposition temperature candidate materials becomes imperative. A successful energetic plasticizer must possess a good density, reasonable sensitivity, low chemical reactivity, and high thermal stability as one approaches oxygen-balanced materials.
Presented will be the synthesis of high-energy melt-castable and propellant plasticizer materials based on strained ring nitroazetidine polynitric ester and cyclobutane polynitric ester materials. In addition, polynitric ester compounds that maximize densities due to the incorporation of aromatic 1,2,4-oxadiazole and furoxan functionalities.

Jesse Sabatini

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Other Mon, 10 Apr 2023 18:15:11 -0400 2023-04-10T16:00:00-04:00 2023-04-10T17:15:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
New Base-Promoted Oxidative and Reductive Coupling Reactions (April 11, 2023 11:30am) https://events.umich.edu/event/103338 103338-21807043@events.umich.edu Event Begins: Tuesday, April 11, 2023 11:30am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our group’s central goal is to discover new concepts in base-promoted reactivity as a means to advance synthetic chemistry. For example, while base-promoted reactions typically accomplish redox neutral transformations, such as the addition of pronucleophiles to electrophiles, we have identified general strategies for base-promoted oxidative and reductive coupling reactions. This talk will discuss the development of these strategies in the context of two methods: the oxidative coupling of arenes with nucleophiles and the reductive defluorinative coupling of trifluoromethylarenes with electrophiles. The mechanistic frameworks of these methods will be compared to traditional base-promoted protocols to demonstrate unique capabilities and broad synthetic potential.
Jeff Bandar (Colorado State University)

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Other Tue, 11 Apr 2023 18:15:11 -0400 2023-04-11T11:30:00-04:00 2023-04-11T13:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Investigating Nanostructure Synthesis Using In Situ TEM (April 11, 2023 4:00pm) https://events.umich.edu/event/96583 96583-21792909@events.umich.edu Event Begins: Tuesday, April 11, 2023 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Understanding the fundamental relationship between atomic structure and material properties is the holy grail of materials sciences. Towards this goal we are working to develop a real-time and atomistic understanding of the mechanistic steps taken during the growth and transformation of crystalline materials. To do this we employ a combination of complementary synthetic and characterization approaches, in particular using in situ ultra-high resolution transmission electron microscopy (TEM) to observe key structural transformations in real-time. Our in situ experiments include directly performing nanomaterial synthesis in the TEM, as well as determining the kinetics of structural phase transformations of as-synthesized inorganic nanocrystals. Further, based on an unexpected observation made during one of these in situ measurements, we have developed a new approach to directly synthesize arrays of crystallographically well-defined nanoscale interfaces. Several examples will be presented to illustrate our approach, including: the real-time observation of the solid-state synthesis of an individual nanocapsule; a post-synthetic structural phase transformation within an individual nanorod; and finally, the creation of new nanostructured architectures using liquid metal nanodroplets.
Beth Guiton (University of Kentucky)

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Other Tue, 11 Apr 2023 18:15:11 -0400 2023-04-11T16:00:00-04:00 2023-04-11T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Science Success Series | Study Break (April 12, 2023 12:00pm) https://events.umich.edu/event/107379 107379-21815930@events.umich.edu Event Begins: Wednesday, April 12, 2023 12:00pm
Location: Chemistry Dow Lab
Organized By: Science Learning Center

Give your brain a moment to rest by taking a study break! Come join us for an hour of connection and conversation with fellow students while coloring. This is a drop-in style event where you can come and go as your schedule allows.

Register on Sessions: https://myumi.ch/2mqXe

Email ScienceSuccessSeries@umich.edu with any questions.

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Well-being Fri, 07 Apr 2023 12:35:42 -0400 2023-04-12T12:00:00-04:00 2023-04-12T13:00:00-04:00 Chemistry Dow Lab Science Learning Center Well-being Coloring page depicting a mountains with the phrase "Create your own calm"
Science Success Series | The Gifts of Imperfection: Guideposts for Wholehearted Living (April 12, 2023 3:00pm) https://events.umich.edu/event/104417 104417-21809041@events.umich.edu Event Begins: Wednesday, April 12, 2023 3:00pm
Location: Chemistry Dow Lab
Organized By: Science Learning Center

Has the fear of falling short of perfection prevented you from putting yourself out there, trying something new, or sharing your ideas? Come join this session to learn about how to cultivate wholehearted living practices through the work of Dr. Brene’ Brown’s book “The Gifts of Imperfection: Guideposts for Wholehearted Living”. This workshop will introduce you to daily actions you can take to let go of the things that hold you back and allow you to cultivate behaviors that support living wholeheartedly.

Register on Sessions: https://myumi.ch/W2Jy1

Email ScienceSuccessSeries@umich.edu with any questions.

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Workshop / Seminar Tue, 04 Apr 2023 08:32:30 -0400 2023-04-12T15:00:00-04:00 2023-04-12T16:30:00-04:00 Chemistry Dow Lab Science Learning Center Workshop / Seminar Book cover of "The Gifts of Imperfection" by Brene' Brown
The role of Cytochrome P450 Metabolism of Dietary Fatty Acids on Neurodegeneration (April 12, 2023 4:00pm) https://events.umich.edu/event/101181 101181-21800914@events.umich.edu Event Begins: Wednesday, April 12, 2023 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Despite decades of research, the mechanism of neurodegeneration remains unclear. Ferroptosis, a non-apoptotic programmed cell death driven by an iron-dependent membrane lipid peroxidation, is an emerging target and mechanism for aging and age-associated neurodegenerative diseases. While membrane lipid peroxidation is one of the molecular hallmarks of ferroptosis, the involvement of specific polyunsaturated fatty acids and their downstream metabolites as endogenous lipid mediators of ferroptosis remains understudied. Here, we hypothesize that cytochrome P450 (CYP)-epoxide hydrolases metabolites of PUFAs are a new class of lipid mediators of ferroptosis. \r\nInvestigating the effects of specific PUFA and PUFA metabolites on ferroptosis are challenging for two main reasons. Firstly, there is a plethora of endogenous biosynthetic and metabolic enzymatic pathways, and these enzymes express differently across diverse tissues. Secondly, the mechanism of ferroptosis is not well-defined or characterized. Therefore, a system approach is likely needed. To overcome these challenges, we employed Caenorhabditis elegans (C. elegans) as a novel simplified biological model. Using a well-established neurodegenerative assay and transgenic C. elegans with green-fluorescent protein-tagged (GFP) neurons, we show that among all the tested PUFAs, only dihomo-gamma-linolenic acid (DGLA) triggers significant ferroptosis-mediated neurodegeneration after one day of exposure. Interestingly, only dopaminergic neurons and, to a lesser extent, glutaminergic neurons were affected in our studies. Using our state-of-the-art oxylipins analysis and comprehensive chemical probes, we identified the dihydroxy- metabolites of DGLA are likely the lipid mediator responsible for DGLA-induced ferroptosis-mediated neurodegeneration. We were also able to show that epoxide hydrolases play a key role in ferroptosis and neurodegeneration. \r\nIn short, our study identified a novel class of endogenous lipid mediators of ferroptosis. Our findings improve our understanding of how PUFA downstream metabolism modulates neurodegeneration. Additionally, the developed C. elegans models and identified dihydroxy- metabolites of DGLA provide a strong foundation for us to further investigate the mechanism of ferroptosis-mediated neurodegeneration that would identify a novel mechanism for ferroptosis and novel therapeutic targets for preventative or disease-altering treatments for neurodegenerative diseases. At the end of this presentation, we will also share the current drug discovery effort to target this metabolism for neurodegenerative diseases.

Kin Sing Stephen Lee (Michigan State University)

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Other Wed, 12 Apr 2023 18:15:09 -0400 2023-04-12T16:00:00-04:00 2023-04-12T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Capillary electrophoresis-mass spectrometry for top-down proteomics: past, current, and future (April 13, 2023 4:00pm) https://events.umich.edu/event/105996 105996-21813536@events.umich.edu Event Begins: Thursday, April 13, 2023 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Top-down proteomics (TDP) aims to characterize the proteome samples in a proteoform-specific manner and accomplish the human proteoform project (PMID: 34767442), which requires highly efficient separation and sensitive detection of proteoforms due to the extremely high sample complexity. Capillary electrophoresis-mass spectrometry (CE-MS) for top-down MS analysis of intact proteins/proteoforms is pioneered by the McLafferty, Lee, and Smith groups in 1990s. CE-MS is a powerful analytical technique for proteoform measurements due to its extremely high efficiency and sensitivity for proteoform separation and detection. However, due to the limitations of MS instrumentation and robustness of CE-MS interface, CE-MS had not been widely adopted until the recent 10 years. During the last decade, CE-MS interface has tremendous improvement in terms of sensitivity and robustness and several interfaces have been commercialized. MS instrumentation has impressive improvement in terms of mass resolution, gas-phase fragmentation performance, speed, and sensitivity. Using the modern instrumentation, it is straightforward to achieve the identification of thousands of proteoforms from whole cell lysates using CE-MS/MS with high reproducibility. For example, our group recently demonstrated the identification of over 23,000 proteoforms from colorectal cancer cells and documented drastically different proteoform profiles between metastatic and non-metastatic colorectal cancer cells using CE-MS/MS (PMID: 36542699). It is also approachable to delineate large proteoforms (e.g., monoclonal antibodies) and membrane proteoforms using CE-MS and MS/MS. We expect that CE-MS will be a powerful analytical tool for high-throughput TDP of various complex biological samples in the next several years.


Liangliang Sun (Michigan State University)

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Other Thu, 13 Apr 2023 18:15:12 -0400 2023-04-13T16:00:00-04:00 2023-04-13T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Engineering Automated Solution to Address Scientific Challenges (April 14, 2023 12:00pm) https://events.umich.edu/event/106805 106805-21814851@events.umich.edu Event Begins: Friday, April 14, 2023 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract:
The biopharmaceutical industry is in a constant state of evolution, and the demand for innovative drug development technologies has never been higher. High-throughput development (HTD) is an emerging field within biopharmaceuticals that offers a unique approach to drug discovery, development, and manufacturing.

During the presentation, the speaker will discuss their journey of transitioning from a traditional scientific background to a more engineering-focused role in HTD. They will cover the challenges and
opportunities that they met along the way, as well as share insights on the interdisciplinary nature of
HTD. Additionally, they will emphasize the importance of remaining curious, resilient, and enthusiastic throughout one’s career when taking advantage of the opportunities presented.

The audience will gain an understanding of the diverse range of career opportunities available in HTD, and how a background in science can help develop skills in engineering and data analysis. This presentation will be valuable for scientists and researchers who are interested in transitioning to roles in HTD, as well as for students and recent graduates who are exploring career opportunities in the
biopharmaceutical industry.

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Workshop / Seminar Thu, 06 Apr 2023 11:38:57 -0400 2023-04-14T12:00:00-04:00 2023-04-14T13:30:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Joseph Lomino
Understanding structure-function relationships in transition-metal-containing enzymes (April 18, 2023 4:00pm) https://events.umich.edu/event/101765 101765-21802331@events.umich.edu Event Begins: Tuesday, April 18, 2023 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The Silakov laboratory seeks to uncover principles underpinning biology\'s control over the reactivity of metal complexes in enzymes. Millions of years of natural selection in harsh, nutrient-limiting environments evolved organisms into highly effective and extremely selective metabolic systems. Organisms from all kingdoms of life are replete with enzymes that facilitate a staggering array of reactions with efficiency using nothing but abundant 3rd-row transition metal ions that is hard to replicate using pure synthetic chemistry approaches. To understand how similar metal-containing catalytic centers can vary their reactivity depending on the protein environment, we employ various advanced experimental methods such as Electron Paramagnetic Resonance and Infrared spectroscopies, (spectro)electrochemistry, and protein film voltammetry. As some knowledge gaps about the function of enzymes stem from the absence of suitable experimental techniques, we also have a strong interested in developing novel biophysical approaches that allow addressing such gaps. This talk will present two case studies performed by the Silakov laboratory: a superfamily of Fe/2OG oxygenases involved in the biosynthesis of natural products, and [FeFe] hydrogenases which are highly effective H2-producing enzymes. The ultimate goal of our fundamental research is to inform the development of new biotechnologies to allow environmentally friendly biosynthetic production of much-needed molecules such as drugs and renewable energy resources.
Alexey Silakov (The Pennsylvania State University)

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Other Tue, 18 Apr 2023 18:15:11 -0400 2023-04-18T16:00:00-04:00 2023-04-18T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Trapping Radical Intermediates (April 19, 2023 4:00pm) https://events.umich.edu/event/106143 106143-21813844@events.umich.edu Event Begins: Wednesday, April 19, 2023 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our group kinetically traps reactive intermediates from group transfer catalysis or small molecule activation processes. The electronic structure and redox distribution of the transition metal(s) radicaloid ligand pairs are assessed using a variety of spectroscopic and theoretical means.
Theodore Betley (Harvard University)

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Other Wed, 19 Apr 2023 06:15:12 -0400 2023-04-19T16:00:00-04:00 2023-04-19T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Atomic-scale Insights into Electrocatalyst Structure and Function (April 20, 2023 4:00pm) https://events.umich.edu/event/96388 96388-21792451@events.umich.edu Event Begins: Thursday, April 20, 2023 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The development of efficient renewable energy conversion and storage devices to curb climate change is one of the most important challenges of the 21st century. This can be addressed by using renewable electricity to manufacture chemical fuels and synthetic precursors, or by generating electricity with carbon-neutral fuel cell devices. However, electrocatalytic processes are hampered by low efficiencies and poor reaction selectivity because of a lack of rational methods available to create controllable catalyst materials with the preferred electrochemical activities. In this seminar Prof. Hall will discuss the use of ordered intermetallic compounds (OICs), which are alloys that display high electrocatalytic activities because their well-defined compositions and long-range atomic scale ordering enable predictable geometric and electronic interactions, in contrast to the more widely studied solid-solution type alloys. However, OIC materials are difficult to synthesize in nanomaterial form because conventional synthesis methods offer poor control over the composition, phase, and morphology. I will discuss our efforts on the synthesis, stability, and catalytic activity of OICs prepared by electrochemical methods at room temperature and atmospheric pressure. Our strategies include the use of electrochemically induced phase transformations which enables us to convert a base metal rich alloy to an OIC richer in nobler metal by removal of the base metal, and the direct production of OIC materials by electrochemical deposition. We will also discuss how we leverage the atomically precise configuration of atoms within OICs to reveal detailed insights into how a material’s structure regulates its electrochemical properties. Developing new methods for preparing OIC compounds under ambient conditions is essential for designing catalysts for the next generation of renewable energy conversion devices




Shoji Hall (Johns Hopkins University)

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Other Thu, 20 Apr 2023 18:15:13 -0400 2023-04-20T16:00:00-04:00 2023-04-20T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
New Insights into Iron Transport in Mycobacterium tuberculosis and beyond (April 25, 2023 4:00pm) https://events.umich.edu/event/95866 95866-21791208@events.umich.edu Event Begins: Tuesday, April 25, 2023 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The highly contagious disease tuberculosis (TB) is caused by the bacterium Mycobacterium tuberculosis (Mtb), which has been evolving drug resistance at an alarming rate due to the harsh, long drug treatments. Like all human pathogens, iron is essential for Mtb’s survival and virulence. Consequently, Mtb iron transport is an emerging drug target. However, the development of anti-TB drugs aimed at these metabolic pathways have been restricted by the dearth of information on Mtb iron acquisition. Mtb has multiple strategies utilized to acquire ferric iron and heme-iron. Mtb iron uptake is a complex process requiring biosynthesis and subsequent export of Mtb siderophores, followed by ferric iron scavenging and ferric-siderophore import into Mtb. Additionally, Mtb uptakes heme and has a Mtb-specific mechanism of heme degradation that yields iron and novel heme-degradation products. Here we present several aspects of these pathways to close the knowledge gaps of iron acquisition in mycobacteria.









Celia Goulding (University of California, Irvine)

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Other Tue, 25 Apr 2023 18:15:15 -0400 2023-04-25T16:00:00-04:00 2023-04-25T17:15:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
HOLD| Condensed Matter/Theoretical Chemistry Seminar: Seonah Kim (May 3, 2023 4:00pm) https://events.umich.edu/event/96520 96520-21792617@events.umich.edu Event Begins: Wednesday, May 3, 2023 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Physical
Seonah Kim

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Other Wed, 03 May 2023 18:15:14 -0400 2023-05-03T16:00:00-04:00 2023-05-03T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Investigating the Electrochemical Behavior of Uranium in Chloride Melts (May 4, 2023 4:00pm) https://events.umich.edu/event/107626 107626-21816295@events.umich.edu Event Begins: Thursday, May 4, 2023 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Molten salt nuclear reactors are a promising technology for the production of green energy. The high boiling points and low vapor pressures of these systems make them considerably safer than traditional light water reactors, and the ability to run molten salt reactors in a breeder/burner configuration results in higher material use efficiency, and lower waste generation. One key challenge associated with these systems is material corrosion, and understanding how actinide materials, such as uranium, can affect corrosion kinetics in these systems is an important goal. In this talk, Dr. Lhermitte outlines the design and construction of the electroanalytical capabilities of the molten salt chemistry laboratory at Los Alamos National Lab to investigate these problems. Key discoveries as part of this work were: the design of a new type of sealed Mg/MgCl2 reference electrode, the preparation of small area electrodes for high resolution cyclic voltammetry, and the development of electromotive force measurements to determine the formal potential of U3+/U0 in chloride melts. Finally, Dr. Lhermitte also outlines how molten salt electrochemical methods can be leveraged to electrodeposit materials with extremely low reduction potentials, such as Zr, for applications as coatings in solid state nuclear fuels.
Charles Lhermitte (Los Alamos National Lab)

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Other Thu, 04 May 2023 18:15:12 -0400 2023-05-04T16:00:00-04:00 2023-05-04T17:15:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Molecular Understanding, Design and Development of Zwitterionic Materials (May 11, 2023 4:00pm) https://events.umich.edu/event/97541 97541-21794695@events.umich.edu Event Begins: Thursday, May 11, 2023 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

An important challenge in many applications is the prevention of unwanted nonspecific biomolecular and microorganism attachment on surfaces. To address this challenge, our goals are twofold. First, we strive to provide a fundamental understanding of nonfouling mechanisms at the molecular level. Second, we aim to develop biocompatible materials based on the molecular principles learned. As a result, we have shown that zwitterionic materials and surfaces are highly resistant to nonspecific protein adsorption and microorganism attachment from complex media. With zwitterionic coatings, hydrogels or nanoparticles, results show no capsule formation upon subcutaneous implantation in mice for one year, expansion of hematopoietic stem and progenitor cells (HSPCs) without differentiation, no anti-coagulants needed for artificial lungs in sheep, no antibodies generated against zwitterionic polymers, and environmentally benign marine coatings. Unlike poly(ethylene glycol) (PEG), there exist diversified zwitterionic molecular structures to accommodate various properties and applications. Furthermore, zwitterionic materials are super-hydrophilic while their PEG counterparts are amphiphilic. Currently, we are integrating immunology into our biomaterials research and translating our biomaterials to applications ranging from cancer vaccine to precision medicine.
Shaoyi Jiang (Cornell University)

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Other Thu, 11 May 2023 18:15:13 -0400 2023-05-11T16:00:00-04:00 2023-05-11T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab