Happening @ Michigan https://events.umich.edu/list/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. NERS Colloquia Series: Turbulence in High-Energy-Density Plasma (October 7, 2022 4:00pm) https://events.umich.edu/event/96987 96987-21793650@events.umich.edu Event Begins: Friday, October 7, 2022 4:00pm
Location: Cooley Building
Organized By: Nuclear Engineering and Radiological Sciences

Abstract
Hydrodynamic instabilities are understood to pose a serious challenge to achieving inertial confinement fusion ignition. During implosion, the injection of cold, inert materials into what should be a hot, burning region quenches energy production. In supernovae undergoing the reverse process of explosion, instabilities are favored to explain the observed transport of material from stellar depths to the outer debris. Yet, questions have remained concerning the true mechanism by which instabilities in such high-energy-density (HED) environments achieve these effects. While in classical fluids, instabilities typically pass through nonlinearity into the disordered phase known as “turbulence,” it has long been questioned whether in a dense plasma the new degrees of freedom (ionization, plasma waves, radiation transport, etc.) might modify or even prohibit that path.With a new generation of HED experiments, the field can at last answer this question in the affirmative, that HED turbulence can develop analogously to classical fluids [Doss et al. Phys. Plasmas 27 032701 (2020)]. Building on the efforts of many in validating early-time behavior, a four-year campaign using LLNL’s National Ignition Facility successfully measured the deeply nonlinear regimes and confirmed that turbulence emerges as the instabilities develop, even in timescales as short as 10s of nanoseconds. Following background and an overview of other families of experiments, we review the Shock/Shear campaign which conclusively demonstrated HED turbulence by studying shear flow subject to the Kelvin-Helmholtz instability, the most well-understood classical route to turbulence. A comprehensive scaling analysis unifies data from over 50 distinct NIF experiments, themselves scaled ~10 orders of magnitude from classical fluid shear experiments.
*This work was conducted under the auspices of the U.S. DOE by LANL under contract 89233218CNA000001. LA-UR-22-24038

Bio
Forrest Doss has since 2011 been a scientist in Los Alamos’s Theoretical Design Division, and since 2018 has also been a liaison to Sandia’s Pulsed Power Sciences Center. He was the long-time PI for LANL’s High-Energy-Density Hydrodynamics Experiments, and is currently Project Leader for Applied Hydrodynamics. He has been principal designer for over 50 shots at NIF, and several experiments on the Sandia Z Machine. Forrest holds degrees in Mechanical Engineering and Physics from West Virginia University, a Certificate of Advanced Study in Math from Cambridge, and a PhD in Applied Physics from UM.

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Lecture / Discussion Tue, 04 Oct 2022 10:17:53 -0400 2022-10-07T16:00:00-04:00 2022-10-07T17:00:00-04:00 Cooley Building Nuclear Engineering and Radiological Sciences Lecture / Discussion NERS Fall 2022 Colloquia Series
NERS Colloquia Series: Glenn Knoll Lecture (October 21, 2022 4:00am) https://events.umich.edu/event/96988 96988-21793651@events.umich.edu Event Begins: Friday, October 21, 2022 4:00am
Location: Cooley Building
Organized By: Nuclear Engineering and Radiological Sciences

Speaker: Josh Grindlay, Center for Astrophysics, Harvard & Smithsonian
"Development of the High Resolution Energetic X-ray Imager (HREXI)"

There are many science goals for HREXI as the imaging detector (16 x 16 CZTs/ASICs) for a coded aperture telescope on 2 SmallSats to be proposed in 2023 as a Small Explorer (SMEX) mission in 2028 followed by 10 additional SmallSats for a MIDEX mission to be proposed in 2028 that would enable (by 2030) the very first Full-Sky, continuous viewing, high-resolution imaging and spectra of Gamma-Ray Bursts (GRBs) from the collapse to stellar mass (~10 - 30 solar mass) black holes from the very first massive stars (PopIII) formed ~100 million years after the Big Bang. These stars cannot individually be observed by the JWST telescope, but HREXI imaging CZT arrays can readily detect their extremely luminous (in X-, Gamma-rays) GRBs and provide measurements of the epoch (in redshift) of these very first massive stars that ionized the Universe. This talk will be mainly about the CdZnTe (CZT) detectors and their readout from 3 - 300 keV for imaging and spectra.

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Lecture / Discussion Fri, 14 Oct 2022 13:38:09 -0400 2022-10-21T04:00:00-04:00 2022-10-21T17:00:00-04:00 Cooley Building Nuclear Engineering and Radiological Sciences Lecture / Discussion NERS Fall 2022 Colloquia Series
NERS Colloquia Series: Exascale Computing Project (October 28, 2022 4:00pm) https://events.umich.edu/event/96989 96989-21793652@events.umich.edu Event Begins: Friday, October 28, 2022 4:00pm
Location: Cooley Building
Organized By: Nuclear Engineering and Radiological Sciences

Abstract:
The ExaSMR project is developing methods and software for coupled Monte Carlo neutron transport and computational fluid dynamics simulations for analysis of nuclear reactors. A part of the larger DOE Exascale Computing Project, ExaSMR is preparing to perform simulations on the nation’s two first exascale computing platforms: the Frontier supercomputer at Oak Ridge National Laboratory and the Aurora machine at Argonne National Laboratory. This talk will provide a brief overview of the Exascale Computing Project, followed by a deep dive into several research topics being investigated by the ExaSMR team. Challenges associated with maximizing the computational performance of both continuous-energy Monte Carlo neutron transport and CFD solvers on GPU-based computing platforms will be addressed, as well as a discussion of strategies for efficiently integrating isotopic depletion into Monte Carlo simulations. Finally, a perspective will be provided on the value of collaboration in computational science applications. Multiple examples will be provided where open engagement beyond typical research teams has resulted in advancements both to individual simulation codes and to the community as a whole.



Bio:
Steven Hamilton is a Senior R&D Staff member in the HPC Methods for Nuclear Applications Group at Oak Ridge National Laboratory, where he has worked since 2011. He received his BS and MS degrees from Georgia Tech in Nuclear Engineering and his PhD from Emory University in Computational Mathematics. Steven currently leads the ExaSMR project, a multiphysics simulation effort targeting advances in nuclear reactor modeling as part of the DOE Exascale Computing Project. His research includes methods for both deterministic and Monte Carlo radiation transport, with a focus on high performance computing and GPU-based computing architectures. He has also worked on nonlinear algorithms for multiphysics simulations as well as linear solvers for computational fluid dynamics solvers. He is an active developer on the Denovo deterministic and Shift Monte Carlo radiation transport codes, both part of ORNL’s SCALE suite of analysis tools.

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Lecture / Discussion Fri, 14 Oct 2022 13:39:11 -0400 2022-10-28T16:00:00-04:00 2022-10-28T17:00:00-04:00 Cooley Building Nuclear Engineering and Radiological Sciences Lecture / Discussion NERS Fall 2022 Colloquia Series
NERS Colloquia Series: High-Resolution Multiphysics for Nuclear Engineering (November 4, 2022 4:00pm) https://events.umich.edu/event/96990 96990-21793653@events.umich.edu Event Begins: Friday, November 4, 2022 4:00pm
Location: Cooley Building
Organized By: Nuclear Engineering and Radiological Sciences

Abstract:
Nuclear reactors represent tightly-coupled physics interactions between thermal-hydraulics, neutronics, material performance, structural mechanics, chemistry, and more. Multiphysics modeling is the practice of accounting for these physics interactions during design and analysis. Recent advancements in high performance computing now enable multiphysics simulations with state-of-the-art Monte Carlo neutron transport and Computational Fluid Dynamics (CFD) tools. This talk will begin with a high-level overview of the most important coupled physics interactions in fission reactors, and then introduce the theory of multiphysics modeling as most commonly applied in nuclear engineering. Current research in Monte Carlo-based multiphysics applications will be summarized in terms of acceleration strategies, stability, field mapping, and software development. Then, multiphysics methods research at Argonne National Laboratory using high-resolution CFD and Monte Carlo tools will be presented through the lens of prismatic high temperature gas reactors. Finally, student opportunities at Argonne National Laboratory for both undergraduate and graduate students will be introduced.



Bio:
Dr. April Novak is the Maria Goeppert-Mayer Fellow in the Computational Sciences Division of Argonne National Laboratory, where she conducts research in multiphysics modeling and simulation, computational thermal-hydraulics, and multiscale methods. April is the lead developer of the Cardinal application, an open-source software tool that couples the NekRS Computational Fluid Dynamics (CFD) and OpenMC Monte Carlo codes to the MOOSE framework. As part of her PhD research, April developed multiscale methods for pebble bed analysis within the coarse-mesh thermal-fluid Pronghorn MOOSE application. She now leads several projects in the high-resolution multiphysics space with applications to fast reactor core radial expansion and gas microreactors, and supports a broad range of nuclear industry collaborations. She has a PhD in nuclear engineering from the University of California, Berkeley (2020) and a B.S. in nuclear engineering from the University of Illinois, Urbana-Champaign (2015).

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Lecture / Discussion Wed, 26 Oct 2022 09:36:18 -0400 2022-11-04T16:00:00-04:00 2022-11-04T17:00:00-04:00 Cooley Building Nuclear Engineering and Radiological Sciences Lecture / Discussion NERS Fall 2022 Colloquia Series
NERS Colloquia Series: Status of US Fast Reactor Research and Technology (November 11, 2022 4:00pm) https://events.umich.edu/event/96991 96991-21793654@events.umich.edu Event Begins: Friday, November 11, 2022 4:00pm
Location: Cooley Building
Organized By: Nuclear Engineering and Radiological Sciences

Abstract:
An overview of national energy policy and fast reactor research and development (R&D) efforts in the U.S. will be provided by Dr. Bo Feng who is the National Technical Director of the U.S. Department of Energy's Fast Reactor Program and the manager of the Reactor and Fuel Cycle Analysis Group from the Argonne National Laboratory. There is significant interest and investment in advanced reactor technologies from the U.S. private sector, with dozens of reactor companies working on advanced nuclear projects for a wide array of capabilities. Specific to fast reactors, about a dozen fast reactor companies formed a U.S. industry group in 2017, the Fast Reactor Working Group, which provides important feedback on R&D priorities to the Department of Energy (DOE), the Nuclear Energy Institute (NEI), and U.S. national laboratories. Recognizing the importance of advanced reactors to meeting the nation’s energy security and climate change goals, the Advanced Reactor Demonstration Program (ARDP) was initiated in fiscal year (FY) 2020 to develop Federal and U.S. nuclear industry partnerships in the construction and demonstration of domestic advanced nuclear reactor designs that are safe and affordable to build and operate. To help implement this program, the Office of Nuclear Energy (NE) issued a funding opportunity announcement (FOA) in May 2020 for the most promising domestic advanced reactor designs across the technology maturity spectrum, and subsequently selected ten projects that can be developed over the next two decades. Four of these projects support the development and future demonstration of fast reactor concepts. In addition to providing an overview of the U.S. fast reactor industry, Dr. Feng will discuss DOE programs including the Versatile Test Reactor, fast reactor metallic fuel qualification, the Fast Reactor Program's R&D in technology development, computational methods, fast reactor databases, and advanced material development.

Bio:
Dr. Bo Feng manages the Reactor and Fuel Cycle Analysis group within the Nuclear Science and Engineering Division and serves as the National Technical Director for DOE-NE’s Fast Reactor R&D Program, a role that oversees a multi-laboratory R&D portfolio that includes fast reactor technology development and testing, methods validation and database development, and advanced material qualification activities. Throughout his career, his research has focused primarily on reactor physics analysis, advanced reactor core design, radiation transport, and fuel cycle systems modeling. Dr. Feng has received several laboratory and national level awards for his research including Secretary of Energy’s Honor Award (2020), Argonne Director’s Award (2016), DOE’s Fuel Cycle R&D Excellence Award (2014), and ANS Thermal Hydraulic Division’s Best Paper Award (2009). Dr. Feng earned his S.B., S.M., and Ph.D. in Nuclear Science and Engineering from the Massachusetts Institute of Technology during his time there from 2003 - 2011.

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Lecture / Discussion Fri, 04 Nov 2022 10:33:21 -0400 2022-11-11T16:00:00-05:00 2022-11-11T17:00:00-05:00 Cooley Building Nuclear Engineering and Radiological Sciences Lecture / Discussion NERS Fall 2022 Colloquia Series
NERS Colloquia Series: Actionable Ideas for Nuclear Threat Reduction (November 18, 2022 4:00pm) https://events.umich.edu/event/96992 96992-21793655@events.umich.edu Event Begins: Friday, November 18, 2022 4:00pm
Location: Cooley Building
Organized By: Nuclear Engineering and Radiological Sciences

Abstract
In this talk, I will give a brief overview of the resurgent role of nuclear weapons in national security strategies, the threat that it poses to the public, and potential risk mitigation approaches. Recent events, including U.S. withdrawal from arms control treaties and the pursuit of new nuclear weapons capabilities in the nine nuclear weapons states, suggest we may be facing a revived nuclear arms race with its dangerous consequences. In this context, during the past two years, a group of US physical scientists has held more than 100 colloquia on nuclear weapons, reaching more than 4,000 attendees, and recruited over 850 scientists to the Physicists Coalition for Nuclear Threat Reduction through which scientists educate themselves and then help educate Congress about the renewed risks of nuclear war and the possibilities for reducing those risks. Members have participated in three advocacy campaigns aimed at ensuring that explosive nuclear testing does not resume, extending the New START treaty, and enacting a no-first-use policy.

After the talk, Dr. Di Fulvio will hold a discussion for any attendees interested in getting involved in nuclear policy advocacy or the Physicists Coalition for Nuclear Threat Reduction.

Bio
Angela Di Fulvio is an assistant professor in the Department of Nuclear, Plasma, and Radiological Engineering (NPRE) at the University of Illinois, director of the Neutron Measurement Laboratory, and a researcher in the technical aspects of nuclear safeguards and nonproliferation. Before joining NPRE, Angela was a research scientist at the University of Michigan where she worked on radiation detection within the framework of the Consortium for Verification Technology. Her current interests include the development of detection systems for safeguards and nonproliferation applications and techniques and algorithms for the radiation protection of the patient in radiation therapy.

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Lecture / Discussion Wed, 17 Aug 2022 09:58:17 -0400 2022-11-18T16:00:00-05:00 2022-11-18T17:30:00-05:00 Cooley Building Nuclear Engineering and Radiological Sciences Lecture / Discussion NERS Fall 2022 Colloquia Series
NERS Colloquia Series: The Thermal-Hydraulics Modeling and Simulation Tools and Developments at the INL (December 2, 2022 4:00pm) https://events.umich.edu/event/96993 96993-21793656@events.umich.edu Event Begins: Friday, December 2, 2022 4:00pm
Location: Cooley Building
Organized By: Nuclear Engineering and Radiological Sciences

Abstract:
As the Department of Energy lead laboratory for nuclear energy research and development, Idaho National Laboratory is preparing modeling and simulation tools to support both the existing nuclear fleet and advanced reactor designs. Dr. Marshall will present some of the thermal hydraulics challenges facing nuclear reactors and the INL research activities to provide modeling solutions for these challenges. Discussion topics will include PWR fuel rod ballooning, dynamic flow induced vibration, oxide layer growth, steam ingress for high temperature gas reactors, thermal striping with liquid sodium, and molten salt corrosion.

Bio:
Dr. Marshall is the engineering manager for the Idaho National Laboratory (INL) Thermal Fluid Systems Methods and Analysis Department. His department develops software for and performs modeling and simulation analyses in support of existing and advanced reactor designs. Dr. Marshall is also a Principal Investigator for the U.S. High Performance Research Reactor program with responsibilities of managing (1) irradiation experiments that support the conversion of Massachusetts Institute Technology Reactor and National Bureau of Standards Reactor from highly enriched uranium to low enriched uranium plate fuel and (2) fluid surface interaction model development at the INL. Dr. Marshall’s background is thermal hydraulics and he has nuclear engineering research experience at INL and commercial experience at General Electric Hitachi Nuclear Energy. He has a Ph.D in nuclear engineering from Rensselaer Polytechnic Institute.

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Lecture / Discussion Fri, 02 Dec 2022 10:49:59 -0500 2022-12-02T16:00:00-05:00 2022-12-02T17:00:00-05:00 Cooley Building Nuclear Engineering and Radiological Sciences Lecture / Discussion NERS Fall 2022 Colloquia Series
Autonomous Medical Robots Guided by Real-Time 3D Imaging (January 12, 2023 3:30pm) https://events.umich.edu/event/102880 102880-21805277@events.umich.edu Event Begins: Thursday, January 12, 2023 3:30pm
Location: Cooley Building
Organized By: Biomedical Engineering

Abstract:
Medical robots can precisely manipulate tools beyond human capabilities and are thus helpful for surgeries involving delicate tissue interactions. When coupled with live 3D imaging, such robots can independently guide surgical instruments in real time. In practice, however, patients receive only limited benefits from such intraprocedural data streams due to the lack of integration between robots and imaging systems with sufficiently high resolution and framerate. In this seminar, I report on work with medical robots that use optical coherence tomography to guide needle insertions for cornea transplantation, enhance surgeon efficiency with live volumetric guidance, and perform autonomous eye imaging. In addition, I discuss using real-time image feedback to adaptively acquire images that break the framerate-resolution barrier during live 3D imaging.

Bio:
Mark Draelos, MD, PhD, is a surgically-trained physician and engineer who develops novel applications of medical robotics and imaging to improve patient care. After finishing Duke University’s Medical Scientist Training Program where he studied biomedical engineering under Prof. Joseph Izatt, Mark completed an internship in general surgery at Duke University Medical Center. Currently, he is an Assistant Professor of Robotics and Ophthalmology at the University of Michigan, where he directs the Image-Guided Medical Robotics Laboratory. Mark has received K99/R00 support from the National Eye Institute.

Zoom:
https://umich.zoom.us/j/91712262512

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Workshop / Seminar Thu, 05 Jan 2023 13:40:07 -0500 2023-01-12T15:30:00-05:00 2023-01-12T16:30:00-05:00 Cooley Building Biomedical Engineering Workshop / Seminar BME classroom set up for a seminar with guests in the audience.
NERS Winter 2023 Colloquia Series (January 13, 2023 4:00pm) https://events.umich.edu/event/100707 100707-21800265@events.umich.edu Event Begins: Friday, January 13, 2023 4:00pm
Location: Cooley Building
Organized By: Nuclear Engineering and Radiological Sciences

For more details, follow the "NERS Colloquia" link to the right. **

Friday, January 6, 2023
CANCELED

Friday, January 13, 2023
Electron Accelerators
Speaker: Bruce Carlsten, Los Alamos National Laboratory

Friday, January 20, 2023
Facility for Rare Isotope Beams and Applications of Nuclear Engineering
Speaker: Takuji Kanemura, Michigan State University

Friday, January 27, 2023
Topic TBA
Speaker: Ling Jian Meng, University of Illinois Urbana-Champaign

Friday, February 3, 2023
Why and How Lightbridge is Developing Advanced Nuclear Fuel
Speaker: Seth Grae, Lightbridge Corporation

Friday, February 10, 2023
Modern Multiscale Kinetic Algorithms for High-Fidelity ICF Capsule and Hohlraum Simulations
Speaker: Luis Chacon, Los Alamos National Laboratory

Friday, February 17, 2023
High-temperature Gas-cooled Reactor Status and Challenges
Speaker: Gerhard Strydom, Idaho National Laboratory

Friday, March 10, 2023
2022 COP Conference Panel
Speaker: Anil Bansal, University of Michigan
Panel Discussion—The November 2022 COP (UN Climate Change) Conference

Friday, March 17, 2023
Speaker: Peter Hotvedt, UM, NERS
Panel Discussion—Student Social Media Presence at the 2022 IAEA Nuclear Power Ministerial Panel

Friday, March 24, 2023
Fuel Design and Developments from a Vendor’s Perspective
Speaker: Jacki Stevens, Framatome

Friday, March 31, 2023
Development of Understandable Artificial Intelligence (UAI) Methods in Physical Sciences
Speaker: Professor Y Z, NERS, U-M

Friday, April 7, 2023
Richard K. Osborn Lecture
Speaker: Kathryn Huff, US Assistant Secretary for Nuclear Energy

Friday, April 14, 2023
Ethical Applications of AI in International Safeguards
Speaker: Chantell Murphy, Y-12 National Security Complex

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Workshop / Seminar Thu, 30 Mar 2023 19:57:23 -0400 2023-01-13T16:00:00-05:00 2023-01-13T17:00:00-05:00 Cooley Building Nuclear Engineering and Radiological Sciences Workshop / Seminar NERS Winter 2023 Colloquia Series
Nuclear Engineering Undergraduate Open House (January 17, 2023 4:30pm) https://events.umich.edu/event/101567 101567-21801525@events.umich.edu Event Begins: Tuesday, January 17, 2023 4:30pm
Location: Cooley Building
Organized By: Nuclear Engineering and Radiological Sciences

The Open House is scheduled from 4:30-7:00pm on 1/17/23 in 2906 Cooley. First-year and undeclared second year students will have the opportunity to connect with Nuclear Engineering students, faculty, and student orgs. If ready, students will also be allowed to declare their Engineering Physics or Nuclear Engineering major. Free food/swag will be provided!

Students can arrive anytime between 4:30-5:30pm. Laboratory tours will begin promptly at 5:30pm (and will go until 7:00pm).

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Reception / Open House Tue, 22 Nov 2022 12:54:07 -0500 2023-01-17T16:30:00-05:00 2023-01-17T19:00:00-05:00 Cooley Building Nuclear Engineering and Radiological Sciences Reception / Open House Advertisement Photo
Multi-Scale Systems Analysis of Metabolic and Mechanical Determinants of Reserve Cardiac Power Output (January 19, 2023 3:30pm) https://events.umich.edu/event/103312 103312-21807011@events.umich.edu Event Begins: Thursday, January 19, 2023 3:30pm
Location: Cooley Building
Organized By: Biomedical Engineering

Abstract:
Exercise capacity, a central factor in determining quality of life in healthy aging as well as cardiovascular disease, is determined by a systems-level interaction of factors that are intrinsic to the heart and myocardium and factors that are extrinsic to the heart. Cardiac intrinsic factors include the metabolic power supply and mechanical pumping power of the myocardium. Extrinsic factors include the capacity of the peripheral vasculature to vasodilate in response to increasing demands of exercising musculature and the autonomic chemo- and baroreflexes. 

     We have developed a whole-heart and whole-body cardiovascular modelling framework to capture and test hypotheses on how specific myocardial, autonomic, and vascular mechanisms determine physiological limitations to cardiac power and output reserve and contribute to diminished left-ventricular power output (LVPO) and exercise intolerance in heart failure. Simulations are driven by a multi-scale model of myocardial metabolism and mechanics. Simulations based on a model parameterization representing a healthy young subject may be used to explore, from a theoretical perspective, if and how myocardial ATP supply can affect myocardial mechanics and power reserve. As an emergent property, the integrated model accurately predicts the oxygen cost of contraction during rest and exercise, yielding the correct quantitative relationship between mechanical power output (in the in vivo whole-body setting) and myocardial mitochondrial oxidative phosphorylation (reflected in myocardial oxygen demand). Simulations also reveal that, under physiological conditions, the myocardial capacity to synthesize ATP at a free energy level needed to drive myocardial mechanics reaches its maximal value at maximal exercise. Thus these theoretical predictions are consistent with the concept that the myocardial energy supply capacity limits physiological cardiac power capacity.

Bio:
Dr. Beard is a Professor in the Department of Molecular and Integrative Physiology and holds affiliate appointments in Biomedical Engineering and Emergency Medicine. His laboratory is focused on systems engineering approaches to understanding the biophysical and biochemical operation of physiological systems. Dr. Beard is the Director of the Virtual Physiological Rat (VPR) project, supported as an NIH National Center for Systems Biology, working to analyze, interpret, simulate, and ultimately predict physiological function in health and disease.

Dr. Beard earned an MS in Applied Mathematics and PhD in Bioengineering in 1997 under the supervision of Dr. James Bassingthwaighte at the University of Washington. After completing his PhD he conducted postdoctoral research at the Courant Institute of New York University, and as a Howard Hughes Medical Institute Postdoctoral Fellow. Before joining the University of Michigan, he was Professor of Physiology at the Medical College of Wisconsin.

Zoom:
https://umich.zoom.us/j/91712262512

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Workshop / Seminar Thu, 12 Jan 2023 11:08:20 -0500 2023-01-19T15:30:00-05:00 2023-01-19T16:30:00-05:00 Cooley Building Biomedical Engineering Workshop / Seminar BME Seminar
NERS Colloquia: Applications of Nuclear Engineering in High Power Accelerators (January 20, 2023 4:00pm) https://events.umich.edu/event/102055 102055-21803400@events.umich.edu Event Begins: Friday, January 20, 2023 4:00pm
Location: Cooley Building
Organized By: Nuclear Engineering and Radiological Sciences

The concept of “smashing atoms on a target” has a long history since early 20th century. As physicists desire more nuclear reactions, the power of the particle beam has been increasing. A prime example of a state-of-art, high-power accelerator is the Facility for Rare Isotope Beams (FRIB) recently completed at Michigan State University (MSU). Open for users in 2022, FRIB is poised to become one of world’s most powerful heavy ion accelerators. As a result of the increased beam power, thermal and radiation damage managements of the beam-interacting components in the high-power accelerator facilities are becoming progressively challenging. On the other hand, the nuclear reactor industry has collected vast amount of expertise in the similar technical challenges. We believe more actively introducing the nuclear engineering expertise to the high-power accelerator field would greatly help advance the development of the high-power accelerators.

In this seminar, I will talk about a brief overview of FRIB and variety of its components and their technical challenges related to the thermal and radiation damage managements. These components include charge stripper, charge selector, production target, beam dump. One of the topics that I will spend time as an example of a success story of the application of the nuclear engineering expertise is the recent development of the liquid lithium stripper. Taking advantage of the nuclear-engineering-based liquid metal technology available at Argonne National Laboratory (ANL), ANL and FRIB have developed the free-jet liquid lithium film. Various previous experiments demonstrated that a liquid lithium free jet is well compatible with an accelerator environment and could handle extreme thermal loading as expected.
Subsequently FRIB built the first free-jet liquid lithium stripper to form a fast-flowing (> 50 m/s), very thin (~10 m), liquid lithium free jet in the FRIB accelerator beam line. Finally the first demonstration of the free-jet liquid lithium stripper was successfully carried out, stably stripping variety of heavy ion beams at FRIB. To follow the success of the stripper development and lead FRIB to success, FRIB wants more nuclear engineers who can tackle thermal and radiation damage managements in the devices that are critical to achieve the ultimate goal of 400 kW uranium beam acceleration.

Bio: Takuji Kanemura studied nuclear engineering at Osaka University in Japan, and received his PhD in Engineering at Osaka University in 2010. The title of his PhD thesis was “Research on wave characteristics of liquid lithium free-surface flow”. He has been interested and involved in liquid metal applications in extreme environments, particularly windowless high power beam targets that involve thermal-hydraulics, fluid dynamic stability of jets, mass transportation in vacuum, and related technologies.
Until he joined the FRIB Laboratory in Michigan State University in 2016, He was involved in R&Ds of the liquid lithium target of IFMIF in Japan (IFMIF stands for the International Fusion Materials Irradiation Facility). Since he joined the FRIB Lab, he has been in charge of the liquid lithium charge stripper and various beam-intercepting devices in the FRIB accelerator. His recent involvement in beam-intercepting devices has broadened his interest into radiation damages in materials.

He also likes running, hiking, camping, reading, watching sports, etc. He finally started appreciating the beauty of classical music thanks to his ten-year-old son who plays the violin.

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Workshop / Seminar Tue, 13 Dec 2022 09:57:58 -0500 2023-01-20T16:00:00-05:00 2023-01-20T17:00:00-05:00 Cooley Building Nuclear Engineering and Radiological Sciences Workshop / Seminar Colloquia
The Mechanics of the Vagina: Deformations, Tears, and Contractions (January 26, 2023 3:30pm) https://events.umich.edu/event/103053 103053-21805781@events.umich.edu Event Begins: Thursday, January 26, 2023 3:30pm
Location: Cooley Building
Organized By: Biomedical Engineering

Abstract:
The vagina is a complex fibromuscular organ with walls that are usually collapsed against each other. The same walls can, however, stretch a great deal during important physiological functions such as conception, pregnancy, and delivery. The remarkable deformations of this organ have not been characterized, despite their impact on women’s health. In this talk, I will offer an overview of the research being conducted in my lab to quantify the unique mechanics and complex microstructure of the vagina by combining advanced experimental, theoretical, and computational methods. The vaginal tissue in the rat model was found to experience very large and highly inhomogeneous deformations in both the active (relaxed) and passive (contracted) states. Over time, the vaginal walls deform very quickly when the loads are first applied and more slowly as the same loads are sustained, revealing their inherent viscoelasticity. Even in the presence of tears, the vagina can undergo large deformations with collagen fibers re-orienting to slow the propagation of tears. Higher contractions occur in the proximal (closer to the cervix) region than in the distal (closer to the introitus) region due to the smooth muscle fiber organization. Data-driven reduced-order modeling techniques are being used to construct in silico models of vaginal deformations, with the accuracy of higher-fidelity models and the speed of simplified models. Future research will explore how mechanical and microstructural properties of the vagina are altered in pathological conditions such as sexual dysfunction, maternal trauma, and pelvic organ prolapse.

Bio:
Raffaella De Vita is a professor and associate department head in the Department of Biomedical Engineering and Mechanics at Virginia Tech. She received her Laurea in Mathematics from La Seconda Università degli Study di Napoli, Italy, in 2000 and her M.S. and Ph.D. from University of Pittsburgh in 2003 and 2005, respectively. She is the recipient of the American Society of Biomechanics President’s award, the NSF CAREER award, the PECASE Award, and several awards for research, teaching, and outreach excellence at Virginia Tech. She is a fellow of the ASME and AIMBE. She has served as an associate editor for the Journal of Elasticity since 2020 and as an associate editor for the Journal of Biomedical Engineering from 2017 to 2022. Her research focuses on determining the relationship between the mechanical behavior and the complex structure of biological systems using theoretical, computational, and experimental methods.

Zoom:
https://umich.zoom.us/j/91712262512

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Workshop / Seminar Mon, 09 Jan 2023 11:21:42 -0500 2023-01-26T15:30:00-05:00 2023-01-26T16:30:00-05:00 Cooley Building Biomedical Engineering Workshop / Seminar BME Seminar
NERS Winter 2023 Colloquia Series (January 27, 2023 4:00pm) https://events.umich.edu/event/100707 100707-21800266@events.umich.edu Event Begins: Friday, January 27, 2023 4:00pm
Location: Cooley Building
Organized By: Nuclear Engineering and Radiological Sciences

For more details, follow the "NERS Colloquia" link to the right. **

Friday, January 6, 2023
CANCELED

Friday, January 13, 2023
Electron Accelerators
Speaker: Bruce Carlsten, Los Alamos National Laboratory

Friday, January 20, 2023
Facility for Rare Isotope Beams and Applications of Nuclear Engineering
Speaker: Takuji Kanemura, Michigan State University

Friday, January 27, 2023
Topic TBA
Speaker: Ling Jian Meng, University of Illinois Urbana-Champaign

Friday, February 3, 2023
Why and How Lightbridge is Developing Advanced Nuclear Fuel
Speaker: Seth Grae, Lightbridge Corporation

Friday, February 10, 2023
Modern Multiscale Kinetic Algorithms for High-Fidelity ICF Capsule and Hohlraum Simulations
Speaker: Luis Chacon, Los Alamos National Laboratory

Friday, February 17, 2023
High-temperature Gas-cooled Reactor Status and Challenges
Speaker: Gerhard Strydom, Idaho National Laboratory

Friday, March 10, 2023
2022 COP Conference Panel
Speaker: Anil Bansal, University of Michigan
Panel Discussion—The November 2022 COP (UN Climate Change) Conference

Friday, March 17, 2023
Speaker: Peter Hotvedt, UM, NERS
Panel Discussion—Student Social Media Presence at the 2022 IAEA Nuclear Power Ministerial Panel

Friday, March 24, 2023
Fuel Design and Developments from a Vendor’s Perspective
Speaker: Jacki Stevens, Framatome

Friday, March 31, 2023
Development of Understandable Artificial Intelligence (UAI) Methods in Physical Sciences
Speaker: Professor Y Z, NERS, U-M

Friday, April 7, 2023
Richard K. Osborn Lecture
Speaker: Kathryn Huff, US Assistant Secretary for Nuclear Energy

Friday, April 14, 2023
Ethical Applications of AI in International Safeguards
Speaker: Chantell Murphy, Y-12 National Security Complex

]]>
Workshop / Seminar Thu, 30 Mar 2023 19:57:23 -0400 2023-01-27T16:00:00-05:00 2023-01-27T17:00:00-05:00 Cooley Building Nuclear Engineering and Radiological Sciences Workshop / Seminar NERS Winter 2023 Colloquia Series
Biomedical Engineering (BME 500) Seminar Series - Kate Wofford, PhD (February 2, 2023 3:30pm) https://events.umich.edu/event/104034 104034-21808299@events.umich.edu Event Begins: Thursday, February 2, 2023 3:30pm
Location: Cooley Building
Organized By: Biomedical Engineering

Abstract:
Traumatic brain injury (TBI) affects millions of individuals annually resulting in disrupted neuronal circuitry, neurological deficits, and neuroinflammation. Resident and peripheral immune cells interact with damaged neurons after TBI and can contribute to chronic neuroinflammation and neuropathology. Dr. Wofford’s research focuses on understanding and controlling neuro-immune interactions as a therapeutic strategy for TBI. In this talk, Dr. Wofford will describe recent experiments investigating neuro-immune interactions in an advanced translational model of TBI and will describe one method to control inflammation at the cellular level.

Bio:
Dr. Kate Wofford trained with Kara Spiller at Drexel University and Kacy Cullen at the University of Pennsylvania for her Ph.D. in Biomedical Engineering where she characterized acute neuroinflammation after brain injury and developed a strategy to reprogram immune cells. Now, Kate is a Postdoctoral Fellow in the lab of Kacy Cullen at the University of Pennsylvania where she uses advanced preclinical models to study behavioral, neuropathological, and immunological consequences of brain injury. Her work has been recognized with receipt of multiple awards including the K99/R00 Career Development Award, F32 National Research Service Award, Koerner Award, Outstanding Scholar in Neuroscience Award, Interdisciplinary Collaboration and Research Excellence Fellowship, Anthony Marmarou Award, Sanjeev Kumar Memorial Award, and the Wan Shih Translational Research Award.

Zoom:
https://umich.zoom.us/j/91712262512

]]>
Workshop / Seminar Wed, 25 Jan 2023 20:41:13 -0500 2023-02-02T15:30:00-05:00 2023-02-02T16:30:00-05:00 Cooley Building Biomedical Engineering Workshop / Seminar BME Seminar Series
NERS Winter 2023 Colloquia Series (February 3, 2023 4:00pm) https://events.umich.edu/event/100707 100707-21800267@events.umich.edu Event Begins: Friday, February 3, 2023 4:00pm
Location: Cooley Building
Organized By: Nuclear Engineering and Radiological Sciences

For more details, follow the "NERS Colloquia" link to the right. **

Friday, January 6, 2023
CANCELED

Friday, January 13, 2023
Electron Accelerators
Speaker: Bruce Carlsten, Los Alamos National Laboratory

Friday, January 20, 2023
Facility for Rare Isotope Beams and Applications of Nuclear Engineering
Speaker: Takuji Kanemura, Michigan State University

Friday, January 27, 2023
Topic TBA
Speaker: Ling Jian Meng, University of Illinois Urbana-Champaign

Friday, February 3, 2023
Why and How Lightbridge is Developing Advanced Nuclear Fuel
Speaker: Seth Grae, Lightbridge Corporation

Friday, February 10, 2023
Modern Multiscale Kinetic Algorithms for High-Fidelity ICF Capsule and Hohlraum Simulations
Speaker: Luis Chacon, Los Alamos National Laboratory

Friday, February 17, 2023
High-temperature Gas-cooled Reactor Status and Challenges
Speaker: Gerhard Strydom, Idaho National Laboratory

Friday, March 10, 2023
2022 COP Conference Panel
Speaker: Anil Bansal, University of Michigan
Panel Discussion—The November 2022 COP (UN Climate Change) Conference

Friday, March 17, 2023
Speaker: Peter Hotvedt, UM, NERS
Panel Discussion—Student Social Media Presence at the 2022 IAEA Nuclear Power Ministerial Panel

Friday, March 24, 2023
Fuel Design and Developments from a Vendor’s Perspective
Speaker: Jacki Stevens, Framatome

Friday, March 31, 2023
Development of Understandable Artificial Intelligence (UAI) Methods in Physical Sciences
Speaker: Professor Y Z, NERS, U-M

Friday, April 7, 2023
Richard K. Osborn Lecture
Speaker: Kathryn Huff, US Assistant Secretary for Nuclear Energy

Friday, April 14, 2023
Ethical Applications of AI in International Safeguards
Speaker: Chantell Murphy, Y-12 National Security Complex

]]>
Workshop / Seminar Thu, 30 Mar 2023 19:57:23 -0400 2023-02-03T16:00:00-05:00 2023-02-03T17:00:00-05:00 Cooley Building Nuclear Engineering and Radiological Sciences Workshop / Seminar NERS Winter 2023 Colloquia Series
Bioink Development to Advance 3D Bioprinting (February 9, 2023 3:30pm) https://events.umich.edu/event/104390 104390-21808994@events.umich.edu Event Begins: Thursday, February 9, 2023 3:30pm
Location: Cooley Building
Organized By: Biomedical Engineering

Abstract:
Cardiac tissue engineering has emerged to create living, human, cardiac tissue outside the body as a model system in the near term and as a clinical replacement for diseased or damaged cardiac muscle in the long term. My laboratory seeks to understand the intricate interplay between the extracellular matrix and cardiac cell types in vivo to guide cardiac tissue engineering efforts in vitro. In the course of this seminar I will share our most surprising mechanistic insights and describe how they now guide the development of novel bioink formulations that enable 3D bioprinting of complex cardiac tissues.

Bio:
Brenda Ogle is Professor and Head of Biomedical Engineering, Professor of Pediatrics, and Director of the Stem Cell Institute at the University of Minnesota. Her research team investigates the impact of extracellular matrix proteins on stem cell behavior especially in the context of the cardiovascular system. Insights gleaned over the years established mechanistic links between integrin engagement and the activity of critical transcription factors and most recently led to the development of optimized, extracellular matrix-based bioinks for 3D printing of cardiac muscle mimics featured in Newsweek. The primary strength of her laboratory is the ability to span multiple subdisciplines within both basic science (i.e., stem cell biology, cell-cell fusion, and extracellular matrices) and engineering (cytometry, instrumentation, and 3D printing) fields. Her work received funding from the National Institutes of Health, the National Science Foundation, the Department of Defense, the American Heart Association, the Coulter Foundation, Regenerative Medicine Minnesota, and MnDRIVE. She has partnered on research projects with Becton Dickinson, iCyt, 3M and Medtronic. Professor Ogle is an elected fellow of the American Institute for Medical and Biological Engineering and the Biomedical Engineering Society. She has served as a member of the Board of Directors of the Biomedical Engineering Society, as co-chair of the Women’s Faculty Cabinet, UMN and is recipient of the Mullen-Spector-Truax Women’s Leadership Award.

]]>
Workshop / Seminar Wed, 01 Feb 2023 17:06:54 -0500 2023-02-09T15:30:00-05:00 2023-02-09T16:30:00-05:00 Cooley Building Biomedical Engineering Workshop / Seminar BME Seminar Series
NERS Winter 2023 Colloquia Series (February 10, 2023 4:00pm) https://events.umich.edu/event/100707 100707-21800268@events.umich.edu Event Begins: Friday, February 10, 2023 4:00pm
Location: Cooley Building
Organized By: Nuclear Engineering and Radiological Sciences

For more details, follow the "NERS Colloquia" link to the right. **

Friday, January 6, 2023
CANCELED

Friday, January 13, 2023
Electron Accelerators
Speaker: Bruce Carlsten, Los Alamos National Laboratory

Friday, January 20, 2023
Facility for Rare Isotope Beams and Applications of Nuclear Engineering
Speaker: Takuji Kanemura, Michigan State University

Friday, January 27, 2023
Topic TBA
Speaker: Ling Jian Meng, University of Illinois Urbana-Champaign

Friday, February 3, 2023
Why and How Lightbridge is Developing Advanced Nuclear Fuel
Speaker: Seth Grae, Lightbridge Corporation

Friday, February 10, 2023
Modern Multiscale Kinetic Algorithms for High-Fidelity ICF Capsule and Hohlraum Simulations
Speaker: Luis Chacon, Los Alamos National Laboratory

Friday, February 17, 2023
High-temperature Gas-cooled Reactor Status and Challenges
Speaker: Gerhard Strydom, Idaho National Laboratory

Friday, March 10, 2023
2022 COP Conference Panel
Speaker: Anil Bansal, University of Michigan
Panel Discussion—The November 2022 COP (UN Climate Change) Conference

Friday, March 17, 2023
Speaker: Peter Hotvedt, UM, NERS
Panel Discussion—Student Social Media Presence at the 2022 IAEA Nuclear Power Ministerial Panel

Friday, March 24, 2023
Fuel Design and Developments from a Vendor’s Perspective
Speaker: Jacki Stevens, Framatome

Friday, March 31, 2023
Development of Understandable Artificial Intelligence (UAI) Methods in Physical Sciences
Speaker: Professor Y Z, NERS, U-M

Friday, April 7, 2023
Richard K. Osborn Lecture
Speaker: Kathryn Huff, US Assistant Secretary for Nuclear Energy

Friday, April 14, 2023
Ethical Applications of AI in International Safeguards
Speaker: Chantell Murphy, Y-12 National Security Complex

]]>
Workshop / Seminar Thu, 30 Mar 2023 19:57:23 -0400 2023-02-10T16:00:00-05:00 2023-02-10T17:00:00-05:00 Cooley Building Nuclear Engineering and Radiological Sciences Workshop / Seminar NERS Winter 2023 Colloquia Series
Biomechanics of the Femoropopliteal Artery in the Lower Limb (February 16, 2023 3:30pm) https://events.umich.edu/event/104391 104391-21808995@events.umich.edu Event Begins: Thursday, February 16, 2023 3:30pm
Location: Cooley Building
Organized By: Biomedical Engineering

Abstract:
Despite years of technological and pharmacological improvements, failure rates remain high for the lower extremity peripheral arterial disease repairs, particularly when the repair devices cross the knee joint. Though much work has been done investigating the pathological processes associated with this failure, the underlying mechanisms remain insufficiently understood. The main arterial segment within the leg, the femoropopliteal artery, appears to be significantly different from other peripheral arteries due to lower blood flow and large deformations experienced during flexion of the limbs. Understanding the magnitude of these deformations in different postures and arterial segments may help improve repair devices through benchtop and computational studies of device-artery interactions. These studies rely on comprehensive assessments of arterial mechanics and structure and call for innovative ways of accounting for patient demographics and risk factors to deliver realistic results. We will summarize our findings related to the quantification of the biomechanical environment of the lower limb arteries, describe their structure and mechanical properties in the context of age and disease, present in vitro and computational frameworks to evaluate device-artery interactions, and introduce a preclinical animal model to assess the performance of new endovascular and open surgical repairs for the lower extremity.​​​​​​​

Bio:
Dr. Kamenskiy earned his Ph.D. in Engineering Mechanics from the University of Nebraska-Lincoln, and started his academic career as an Assistant Professor in the Department of Surgery at the University of Nebraska Medical Center. After advancing through the academic ranks and receiving tenure in Surgery, Dr. Kamenskiy joined the Department of Biomechanics at the University of Nebraska at Omaha, where he currently serves as Department Chair. In his research, Dr. Kamenskiy integrates Biomechanics and Medicine using in vivo, ex vivo, in vitro, and in silico methods. His lab is interested in vascular mechanophysiology, mechanobiology, and aging and closely collaborates with vascular surgeon-scientists who share the goal of developing practical solutions to improve clinical outcomes for vascular disease patients. Dr. Kamenskiy has assembled one of the largest databases of human artery mechanical, structural, and demographic characteristics that includes well over 1,000 specimens 12 to 99 years old. This database is a unique resource for understanding the complex and diverse pathology of human blood vessels. In addition to studying ex vivo arteries, the team of Dr. Kamenskiy also utilizes cell and organ culture systems and large animal models to explore the disease pathways they observe in human tissues. This research is accompanied by designing, modeling, and testing of new vascular and endovascular repair materials and devices for various vascular pathologies and trauma that his team carries out using bench-top, porcine, human cadaver, and clinical experiments.

Zoom:
https://umich.zoom.us/j/91712262512

]]>
Workshop / Seminar Wed, 01 Feb 2023 17:33:02 -0500 2023-02-16T15:30:00-05:00 2023-02-16T16:30:00-05:00 Cooley Building Biomedical Engineering Workshop / Seminar BME Seminar Series
NERS Winter 2023 Colloquia Series (February 17, 2023 4:00pm) https://events.umich.edu/event/100707 100707-21800269@events.umich.edu Event Begins: Friday, February 17, 2023 4:00pm
Location: Cooley Building
Organized By: Nuclear Engineering and Radiological Sciences

For more details, follow the "NERS Colloquia" link to the right. **

Friday, January 6, 2023
CANCELED

Friday, January 13, 2023
Electron Accelerators
Speaker: Bruce Carlsten, Los Alamos National Laboratory

Friday, January 20, 2023
Facility for Rare Isotope Beams and Applications of Nuclear Engineering
Speaker: Takuji Kanemura, Michigan State University

Friday, January 27, 2023
Topic TBA
Speaker: Ling Jian Meng, University of Illinois Urbana-Champaign

Friday, February 3, 2023
Why and How Lightbridge is Developing Advanced Nuclear Fuel
Speaker: Seth Grae, Lightbridge Corporation

Friday, February 10, 2023
Modern Multiscale Kinetic Algorithms for High-Fidelity ICF Capsule and Hohlraum Simulations
Speaker: Luis Chacon, Los Alamos National Laboratory

Friday, February 17, 2023
High-temperature Gas-cooled Reactor Status and Challenges
Speaker: Gerhard Strydom, Idaho National Laboratory

Friday, March 10, 2023
2022 COP Conference Panel
Speaker: Anil Bansal, University of Michigan
Panel Discussion—The November 2022 COP (UN Climate Change) Conference

Friday, March 17, 2023
Speaker: Peter Hotvedt, UM, NERS
Panel Discussion—Student Social Media Presence at the 2022 IAEA Nuclear Power Ministerial Panel

Friday, March 24, 2023
Fuel Design and Developments from a Vendor’s Perspective
Speaker: Jacki Stevens, Framatome

Friday, March 31, 2023
Development of Understandable Artificial Intelligence (UAI) Methods in Physical Sciences
Speaker: Professor Y Z, NERS, U-M

Friday, April 7, 2023
Richard K. Osborn Lecture
Speaker: Kathryn Huff, US Assistant Secretary for Nuclear Energy

Friday, April 14, 2023
Ethical Applications of AI in International Safeguards
Speaker: Chantell Murphy, Y-12 National Security Complex

]]>
Workshop / Seminar Thu, 30 Mar 2023 19:57:23 -0400 2023-02-17T16:00:00-05:00 2023-02-17T17:00:00-05:00 Cooley Building Nuclear Engineering and Radiological Sciences Workshop / Seminar NERS Winter 2023 Colloquia Series
Dissecting a post-translational modification code in cardiac reprogramming (February 23, 2023 3:30pm) https://events.umich.edu/event/105100 105100-21810752@events.umich.edu Event Begins: Thursday, February 23, 2023 3:30pm
Location: Cooley Building
Organized By: Biomedical Engineering

Abstract:
Cell fate conversion is associated with extensive epigenetic and post translational modifications (PTMs) and architectural changes of sub-organelles and organelles, yet how these events are interconnected remains unknown. We report here the identification of a phosphorylation code in 14-3-3 binding motifs (PC14-3-3) that greatly stimulates induced cardiomyocyte (iCM) formation from fibroblasts. PC14-3-3 was identified in pivotal functional proteins for iCM reprogramming, including transcription factors and epigenetic factors. Akt1 kinase and PP2A phosphatase were a key writer and eraser of the PC14-3-3 code, respectively. PC14-3-3 activation induces iCM formation with the presence of only Tbx5. In contrast, PC14-3-3 inhibition by mutagenesis or inhibitor-mediated code removal abolished reprogramming. We discovered that key PC14-3-3 embedded factors, such as Hdac4, Mef2c, Nrip1, and Foxo1, formed Hdac4 organized inhibitory nuclear condensates. Notably, PC14-3-3 activation disrupted Hdac4 condensates to promote cardiac gene expression. Our study suggests that sub-organelle dynamics regulated by a post-translational modification code could be a general mechanism for stimulating cell reprogramming and organ regeneration.

Bio:
Dr. Zhong Wang is an Associate Professor of Cardiac Surgery, at the University of Michigan Medical School. The long-term goal of the Wang laboratory is to develop heart therapies to effectively prolong and improve the life of patients with cardiovascular disease. The Wang laboratory has made significant progress in four research directions. One research direction is to define the epigenetic mechanism mediated by ATP-dependent chromatin remodeling in cardiac progenitor specification and differentiation. Direction two is to define essential cross-talks between energy metabolism and epigenetics in heart repair and regeneration. Direction three is to identify epigenetic and post-translational modification mechanism and related molecules in stimulating reprogramming of fibroblasts into cardiomyocytes for heart regeneration. And direction four is to explore novel strategies combining optimal cardiovascular cell types and bioengineering/biomaterials for heart cell therapy.

]]>
Workshop / Seminar Fri, 17 Feb 2023 12:33:28 -0500 2023-02-23T15:30:00-05:00 2023-02-23T16:30:00-05:00 Cooley Building Biomedical Engineering Workshop / Seminar BME Seminar Series
NERS Winter 2023 Colloquia Series (March 10, 2023 4:00pm) https://events.umich.edu/event/100707 100707-21800270@events.umich.edu Event Begins: Friday, March 10, 2023 4:00pm
Location: Cooley Building
Organized By: Nuclear Engineering and Radiological Sciences

For more details, follow the "NERS Colloquia" link to the right. **

Friday, January 6, 2023
CANCELED

Friday, January 13, 2023
Electron Accelerators
Speaker: Bruce Carlsten, Los Alamos National Laboratory

Friday, January 20, 2023
Facility for Rare Isotope Beams and Applications of Nuclear Engineering
Speaker: Takuji Kanemura, Michigan State University

Friday, January 27, 2023
Topic TBA
Speaker: Ling Jian Meng, University of Illinois Urbana-Champaign

Friday, February 3, 2023
Why and How Lightbridge is Developing Advanced Nuclear Fuel
Speaker: Seth Grae, Lightbridge Corporation

Friday, February 10, 2023
Modern Multiscale Kinetic Algorithms for High-Fidelity ICF Capsule and Hohlraum Simulations
Speaker: Luis Chacon, Los Alamos National Laboratory

Friday, February 17, 2023
High-temperature Gas-cooled Reactor Status and Challenges
Speaker: Gerhard Strydom, Idaho National Laboratory

Friday, March 10, 2023
2022 COP Conference Panel
Speaker: Anil Bansal, University of Michigan
Panel Discussion—The November 2022 COP (UN Climate Change) Conference

Friday, March 17, 2023
Speaker: Peter Hotvedt, UM, NERS
Panel Discussion—Student Social Media Presence at the 2022 IAEA Nuclear Power Ministerial Panel

Friday, March 24, 2023
Fuel Design and Developments from a Vendor’s Perspective
Speaker: Jacki Stevens, Framatome

Friday, March 31, 2023
Development of Understandable Artificial Intelligence (UAI) Methods in Physical Sciences
Speaker: Professor Y Z, NERS, U-M

Friday, April 7, 2023
Richard K. Osborn Lecture
Speaker: Kathryn Huff, US Assistant Secretary for Nuclear Energy

Friday, April 14, 2023
Ethical Applications of AI in International Safeguards
Speaker: Chantell Murphy, Y-12 National Security Complex

]]>
Workshop / Seminar Thu, 30 Mar 2023 19:57:23 -0400 2023-03-10T16:00:00-05:00 2023-03-10T17:00:00-05:00 Cooley Building Nuclear Engineering and Radiological Sciences Workshop / Seminar NERS Winter 2023 Colloquia Series
Automated Design to Engineer Organisms: Scaling up Synthetic Biology to Tackle Humanity's Challenges (March 16, 2023 3:30pm) https://events.umich.edu/event/106090 106090-21813703@events.umich.edu Event Begins: Thursday, March 16, 2023 3:30pm
Location: Cooley Building
Organized By: Biomedical Engineering

Automated Design to Engineer Organisms: Scaling up Synthetic Biology to Tackle Humanity's Challenges

Abstract:
Organism engineering is the bedrock of biotechnology from producing high-value products (enzymes, materials, therapeutics) to developing cell therapies. With the latest techniques in DNA synthesis and assembly, it is now possible to construct large genetic systems with (just about) any DNA sequence of interest, enabling one to engineer sophisticated genetic systems inside cells with many genetic parts. Engineered genetic systems can act as sensors, circuits, and actuators to detect environmental states and autonomously act to change them, for example, probiotic bacteria that sense body temperatures to activate the expression of enzymes that treat metabolic diseases. However, it remains highly challenging to build such genetic systems with high-performance behaviors; there are many “tunable knobs” and inter-dependent interactions that create a “curse of dimensionality” with cryptic (unaccounted for) effects. To overcome these challenges, new approaches are needed that parallel the development of a modern engineering discipline centered around organism engineering.

Specifically, we show that it is now possible to rationally engineer genetic systems by combining predictive models of gene expression together with sequence design algorithms. Our models utilize statistical thermodynamics, kinetics, and machine learning to predict how DNA sequence controls transcription rates, translation rates, mRNA decay rates, gene regulation, and more. Leveraging these model predictions, we automate the design of genetic parts and systems (long DNA sequences) using multi-objective optimization to ensure the engineered organisms have the desired specifications (maximizing target functions, while minimizing undesired behaviors). To develop and test these models, we utilize the latest advances in oligopool synthesis, library-based cloning, and next-generation sequencing to carry out thousands of defined experiments per workflow. We illustrate our rational design approach with several recent applications, including engineering genetic systems to sense-and-respond to human biomarker proteins inside cell-free assays for medical diagnostics and engineering genetic systems to sense-and-respond to TNT inside soil systems for countermine detection.

We have also developed an interactive web-based design platform for engineering organisms, which now has over 10000 registered researchers who have designed over 900,000 genetic systems for diverse biotech applications (medical, industrial, agricultural, defense). The platform provides a “no-code” interface to our suite of predictive models & design algorithms, enabling its broad usage by the community. Altogether, these efforts demonstrate that physiochemical models can indeed predict biological functions with sufficient accuracy to automatically design genetic systems with high performance behaviors.

Bio:
Prof. Howard Salis is an Associate Professor in the Biological Engineering, Chemical Engineering, and Biomedical Engineering departments at Penn State University. He is also a member of the Bioinformatics & Genomics and Molecular, Cellular, & Integrative Biosciences graduate programs. Prof. Salis’ expertise is in the design & engineering of genetic systems in microbial organisms for diverse biotech applications (industrial, medical, agricultural, defense). His lab’s mission is to co-develop a new engineering discipline for biology through the development of predictive models & design algorithms that circumvent the need for trial-and-error experimentation. To develop and test these approaches, his lab carries out thousands of defined experiments per workflow utilizing the latest in oligopool synthesis and next-generation sequencing. Prof. Salis has received the DARPA Young Faculty award and the NSF CAREER award for his achievements. He is also the founder of De Novo DNA, which runs a web-based design platform for engineering organisms, used by over 10000 researchers to design over 900000 genetic systems for diverse biotech applications. Prof. Salis earned his B.S. in Chemical Engineering from Rutgers University (2002) and his Ph.D. in Chemical Engineering from the University of Minnesota (2007). He was a postdoc at UCSF with Chris Voigt (2007-2009). He joined Penn State University in 2010.

Zoom:
https://umich.zoom.us/j/91712262512

]]>
Workshop / Seminar Sat, 11 Mar 2023 21:25:37 -0500 2023-03-16T15:30:00-04:00 2023-03-16T16:30:00-04:00 Cooley Building Biomedical Engineering Workshop / Seminar BME Seminar Series
NERS Winter 2023 Colloquia Series (March 17, 2023 4:00pm) https://events.umich.edu/event/100707 100707-21800271@events.umich.edu Event Begins: Friday, March 17, 2023 4:00pm
Location: Cooley Building
Organized By: Nuclear Engineering and Radiological Sciences

For more details, follow the "NERS Colloquia" link to the right. **

Friday, January 6, 2023
CANCELED

Friday, January 13, 2023
Electron Accelerators
Speaker: Bruce Carlsten, Los Alamos National Laboratory

Friday, January 20, 2023
Facility for Rare Isotope Beams and Applications of Nuclear Engineering
Speaker: Takuji Kanemura, Michigan State University

Friday, January 27, 2023
Topic TBA
Speaker: Ling Jian Meng, University of Illinois Urbana-Champaign

Friday, February 3, 2023
Why and How Lightbridge is Developing Advanced Nuclear Fuel
Speaker: Seth Grae, Lightbridge Corporation

Friday, February 10, 2023
Modern Multiscale Kinetic Algorithms for High-Fidelity ICF Capsule and Hohlraum Simulations
Speaker: Luis Chacon, Los Alamos National Laboratory

Friday, February 17, 2023
High-temperature Gas-cooled Reactor Status and Challenges
Speaker: Gerhard Strydom, Idaho National Laboratory

Friday, March 10, 2023
2022 COP Conference Panel
Speaker: Anil Bansal, University of Michigan
Panel Discussion—The November 2022 COP (UN Climate Change) Conference

Friday, March 17, 2023
Speaker: Peter Hotvedt, UM, NERS
Panel Discussion—Student Social Media Presence at the 2022 IAEA Nuclear Power Ministerial Panel

Friday, March 24, 2023
Fuel Design and Developments from a Vendor’s Perspective
Speaker: Jacki Stevens, Framatome

Friday, March 31, 2023
Development of Understandable Artificial Intelligence (UAI) Methods in Physical Sciences
Speaker: Professor Y Z, NERS, U-M

Friday, April 7, 2023
Richard K. Osborn Lecture
Speaker: Kathryn Huff, US Assistant Secretary for Nuclear Energy

Friday, April 14, 2023
Ethical Applications of AI in International Safeguards
Speaker: Chantell Murphy, Y-12 National Security Complex

]]>
Workshop / Seminar Thu, 30 Mar 2023 19:57:23 -0400 2023-03-17T16:00:00-04:00 2023-03-17T17:00:00-04:00 Cooley Building Nuclear Engineering and Radiological Sciences Workshop / Seminar NERS Winter 2023 Colloquia Series
Dynamic communication networks between regulatory T cells and mesenchymal stromal cells regulate muscle repair and regeneration (March 23, 2023 3:30pm) https://events.umich.edu/event/106476 106476-21814329@events.umich.edu Event Begins: Thursday, March 23, 2023 3:30pm
Location: Cooley Building
Organized By: Biomedical Engineering

Abstract:

Tissue repair and regeneration require a temporally coordinated immune response to clear affected areas and rebuild tissue architecture. To study the dynamic regulation of muscle repair, we generated a time-resolved single-cell RNA sequencing dataset of regulatory T cells (Tregs) and mesenchymal stromal cells (MSCs) in a mouse model of skeletal muscle injury. We built a computational tool to predict the dynamic cellular communication networks between these cell types and found distinct communication pathways during different phases of repair. Using a combination of in vivo CRISPR and genetic mouse models, we validated these interactions and identified novel communication pathways that regulate tissue regeneration.



Short Bio:

Dr. Andrés Muñoz-Rojas is originally from Mexico City. He has a degree in Bioengineering from the University of Pennsylvania. Andrés got his PhD in Biomedical Engineering at Yale University, where he worked with Dr. Kathryn Miller-Jensen using single-cell secretion and transcription technologies to study macrophage polarization in vitro and in tumor microenvironments. He then joined the lab of Diane Mathis at Harvard Medical School as a Postdoctoral Fellow to study tissue immunology and explore the role of Tregs in regulating tissue function.

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Workshop / Seminar Mon, 20 Mar 2023 13:37:03 -0400 2023-03-23T15:30:00-04:00 2023-03-23T16:30:00-04:00 Cooley Building Biomedical Engineering Workshop / Seminar BME Seminar Series
NERS Winter 2023 Colloquia Series (March 24, 2023 4:00pm) https://events.umich.edu/event/100707 100707-21800272@events.umich.edu Event Begins: Friday, March 24, 2023 4:00pm
Location: Cooley Building
Organized By: Nuclear Engineering and Radiological Sciences

For more details, follow the "NERS Colloquia" link to the right. **

Friday, January 6, 2023
CANCELED

Friday, January 13, 2023
Electron Accelerators
Speaker: Bruce Carlsten, Los Alamos National Laboratory

Friday, January 20, 2023
Facility for Rare Isotope Beams and Applications of Nuclear Engineering
Speaker: Takuji Kanemura, Michigan State University

Friday, January 27, 2023
Topic TBA
Speaker: Ling Jian Meng, University of Illinois Urbana-Champaign

Friday, February 3, 2023
Why and How Lightbridge is Developing Advanced Nuclear Fuel
Speaker: Seth Grae, Lightbridge Corporation

Friday, February 10, 2023
Modern Multiscale Kinetic Algorithms for High-Fidelity ICF Capsule and Hohlraum Simulations
Speaker: Luis Chacon, Los Alamos National Laboratory

Friday, February 17, 2023
High-temperature Gas-cooled Reactor Status and Challenges
Speaker: Gerhard Strydom, Idaho National Laboratory

Friday, March 10, 2023
2022 COP Conference Panel
Speaker: Anil Bansal, University of Michigan
Panel Discussion—The November 2022 COP (UN Climate Change) Conference

Friday, March 17, 2023
Speaker: Peter Hotvedt, UM, NERS
Panel Discussion—Student Social Media Presence at the 2022 IAEA Nuclear Power Ministerial Panel

Friday, March 24, 2023
Fuel Design and Developments from a Vendor’s Perspective
Speaker: Jacki Stevens, Framatome

Friday, March 31, 2023
Development of Understandable Artificial Intelligence (UAI) Methods in Physical Sciences
Speaker: Professor Y Z, NERS, U-M

Friday, April 7, 2023
Richard K. Osborn Lecture
Speaker: Kathryn Huff, US Assistant Secretary for Nuclear Energy

Friday, April 14, 2023
Ethical Applications of AI in International Safeguards
Speaker: Chantell Murphy, Y-12 National Security Complex

]]>
Workshop / Seminar Thu, 30 Mar 2023 19:57:23 -0400 2023-03-24T16:00:00-04:00 2023-03-24T17:00:00-04:00 Cooley Building Nuclear Engineering and Radiological Sciences Workshop / Seminar NERS Winter 2023 Colloquia Series
Diagnosing disease on a microchip: Finding nanoscale needles in a nanoscale haystack (March 30, 2023 3:30pm) https://events.umich.edu/event/106711 106711-21814734@events.umich.edu Event Begins: Thursday, March 30, 2023 3:30pm
Location: Cooley Building
Organized By: Biomedical Engineering

Abstract: The transformative growth in microelectronics in the latter half of the 20th century was fueled fundamentally by the ability to miniaturize complex circuits onto chips. The impact of this has been profound– computing is pervasive and portable and communication is instant and global. My research aims to harness this same engineering approach to solve high impact problems in medical diagnostics. To accomplish this goal my lab develops hybrid microchips, where microfluidics are built directly on top of semiconductor chips. In this talk I will focus on recent work at Penn on 'digital asays.' Digital assays — in which ultra-sensitive molecular measurements are made by performing millions of parallel experiments in picoliter droplets — have generated enormous enthusiasm due to their single molecule resolution. These assays have incredible untapped potential for disease diagnostics but are currently confined to laboratory settings due to the instrumentation necessary to generate, control, and measure tens of millions of droplets. To overcome this challenge, we are developing a hybrid microelectronic / microfluidic chip to ‘unlock’ droplet-based assays for mobile use. Our microDroplet Fluorescence Detector (µDFD) takes inspiration from cellular networks, in which phones are identified by their carrier frequency and not their particular location. In collaboration with physicians at The Abramson Cancer Center, we are demonstrating the power of this approach by developing a multiplexed exosome-based diagnostic for the early detection of pancreatic cancer.

Bio: The Issadore lab combines microelectronics, microfluidics, nanomaterials, and machine learning to solve big problems in healthcare. We create miniaturized platforms for the diagnosis of disease, we develop new platforms to manufacture micro and nanomaterials, and we dip our toes into an assortment of other areas where we can leverage our engineering training to improve healthcare. This work requires an interdisciplinary approach in which engineers, scientists, and physicians work together in teams.

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Workshop / Seminar Sat, 25 Mar 2023 18:10:52 -0400 2023-03-30T15:30:00-04:00 2023-03-30T16:30:00-04:00 Cooley Building Biomedical Engineering Workshop / Seminar BME Seminar Series
NERS Winter 2023 Colloquia Series (March 31, 2023 4:00pm) https://events.umich.edu/event/100707 100707-21800273@events.umich.edu Event Begins: Friday, March 31, 2023 4:00pm
Location: Cooley Building
Organized By: Nuclear Engineering and Radiological Sciences

For more details, follow the "NERS Colloquia" link to the right. **

Friday, January 6, 2023
CANCELED

Friday, January 13, 2023
Electron Accelerators
Speaker: Bruce Carlsten, Los Alamos National Laboratory

Friday, January 20, 2023
Facility for Rare Isotope Beams and Applications of Nuclear Engineering
Speaker: Takuji Kanemura, Michigan State University

Friday, January 27, 2023
Topic TBA
Speaker: Ling Jian Meng, University of Illinois Urbana-Champaign

Friday, February 3, 2023
Why and How Lightbridge is Developing Advanced Nuclear Fuel
Speaker: Seth Grae, Lightbridge Corporation

Friday, February 10, 2023
Modern Multiscale Kinetic Algorithms for High-Fidelity ICF Capsule and Hohlraum Simulations
Speaker: Luis Chacon, Los Alamos National Laboratory

Friday, February 17, 2023
High-temperature Gas-cooled Reactor Status and Challenges
Speaker: Gerhard Strydom, Idaho National Laboratory

Friday, March 10, 2023
2022 COP Conference Panel
Speaker: Anil Bansal, University of Michigan
Panel Discussion—The November 2022 COP (UN Climate Change) Conference

Friday, March 17, 2023
Speaker: Peter Hotvedt, UM, NERS
Panel Discussion—Student Social Media Presence at the 2022 IAEA Nuclear Power Ministerial Panel

Friday, March 24, 2023
Fuel Design and Developments from a Vendor’s Perspective
Speaker: Jacki Stevens, Framatome

Friday, March 31, 2023
Development of Understandable Artificial Intelligence (UAI) Methods in Physical Sciences
Speaker: Professor Y Z, NERS, U-M

Friday, April 7, 2023
Richard K. Osborn Lecture
Speaker: Kathryn Huff, US Assistant Secretary for Nuclear Energy

Friday, April 14, 2023
Ethical Applications of AI in International Safeguards
Speaker: Chantell Murphy, Y-12 National Security Complex

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Workshop / Seminar Thu, 30 Mar 2023 19:57:23 -0400 2023-03-31T16:00:00-04:00 2023-03-31T17:00:00-04:00 Cooley Building Nuclear Engineering and Radiological Sciences Workshop / Seminar NERS Winter 2023 Colloquia Series
Hallucinations and objective assessments of deep learning technologies for medical image formation (April 6, 2023 3:30pm) https://events.umich.edu/event/107076 107076-21815261@events.umich.edu Event Begins: Thursday, April 6, 2023 3:30pm
Location: Cooley Building
Organized By: Biomedical Engineering

Abstract:
A variety of deep learning-based image restoration and reconstruction methods, generically referred to as image formation methods, have been proposed for use with biomedical images. It is widely accepted that the assessment and refinement of biomedical imaging technologies should be performed by objective, i.e., task-based, measures of image quality (IQ). However, the objective evaluation of deep learning-based image formation technologies remains largely lacking, despite the breakneck speed at which they are being developed. As such, there is an ever-growing collection of methods whose utility and trustworthiness remains largely unknown. Moreover, such methods have the capability to ‘hallucinate’ false structures, which is of significant concern in medical imaging applications. In this work, we report studies in which the performance of deep learning-based image restoration methods is objectively assessed. The performance of the ideal observer (IO) and common linear numerical observers are quantified, and detection efficiencies are computed to assess the impact of deep learning image formation methods on signal detection performance. The numerical results indicate that, in the cases considered, the application of a deep image formation network can result in a loss of task-relevant information in the image, despite improvement in traditional computer-vision metrics. We also demonstrate that traditional and objective IQ measures can vary in opposite ways as a function of network depth. These results highlight the need for the objective evaluation of IQ for deep image formation technologies and may suggest future avenues for improving the effectiveness of medical imaging applications. 

Bio:
Dr. Mark Anastasio is the Donald Biggar Willett Professor in Engineering and the Head of the Department of Bioengineering at the University of Illinois at Urbana-Champaign (UIUC). Before joining UIUC in 2019, he was a Professor of Biomedical Engineering at Washington University in St. Louis, where he established one of the nation’s first stand-alone PhD programs in imaging science. Dr. Anastasio’s research accomplishments to the fields of biomedical imaging and image science have been numerous and impactful and his general interests broadly address the computational aspects of image formation, modern imaging science, and applied machine learning. He has conducted research in the fields of diffraction tomography, X-ray phase-contrast imaging, and ultrasound tomography. He one of the world’s leading authorities on photoacoustic computed tomography (PACT) and has made numerous and important contributions to development of PACT for over fifteen years. He has published over 175 peer-reviewed journal papers in leading imaging and optical science journals and was the recipient of a National Science Foundation (NSF) CAREER Award to develop image reconstruction methods. He is a Fellow of the American Institute for Medical and Biological Engineering (AIMBE), the International Academy of Medical and Biological Engineering (IAMBE) and the SPIE. He also served as the Chair of the NIH BMIT-B and EITA Study Sections.

Zoom:
https://umich.zoom.us/j/91712262512

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Workshop / Seminar Fri, 31 Mar 2023 14:53:29 -0400 2023-04-06T15:30:00-04:00 2023-04-06T16:30:00-04:00 Cooley Building Biomedical Engineering Workshop / Seminar BME Seminar Series
NERS Winter 2023 Colloquia Series (April 7, 2023 4:00pm) https://events.umich.edu/event/100707 100707-21800274@events.umich.edu Event Begins: Friday, April 7, 2023 4:00pm
Location: Cooley Building
Organized By: Nuclear Engineering and Radiological Sciences

For more details, follow the "NERS Colloquia" link to the right. **

Friday, January 6, 2023
CANCELED

Friday, January 13, 2023
Electron Accelerators
Speaker: Bruce Carlsten, Los Alamos National Laboratory

Friday, January 20, 2023
Facility for Rare Isotope Beams and Applications of Nuclear Engineering
Speaker: Takuji Kanemura, Michigan State University

Friday, January 27, 2023
Topic TBA
Speaker: Ling Jian Meng, University of Illinois Urbana-Champaign

Friday, February 3, 2023
Why and How Lightbridge is Developing Advanced Nuclear Fuel
Speaker: Seth Grae, Lightbridge Corporation

Friday, February 10, 2023
Modern Multiscale Kinetic Algorithms for High-Fidelity ICF Capsule and Hohlraum Simulations
Speaker: Luis Chacon, Los Alamos National Laboratory

Friday, February 17, 2023
High-temperature Gas-cooled Reactor Status and Challenges
Speaker: Gerhard Strydom, Idaho National Laboratory

Friday, March 10, 2023
2022 COP Conference Panel
Speaker: Anil Bansal, University of Michigan
Panel Discussion—The November 2022 COP (UN Climate Change) Conference

Friday, March 17, 2023
Speaker: Peter Hotvedt, UM, NERS
Panel Discussion—Student Social Media Presence at the 2022 IAEA Nuclear Power Ministerial Panel

Friday, March 24, 2023
Fuel Design and Developments from a Vendor’s Perspective
Speaker: Jacki Stevens, Framatome

Friday, March 31, 2023
Development of Understandable Artificial Intelligence (UAI) Methods in Physical Sciences
Speaker: Professor Y Z, NERS, U-M

Friday, April 7, 2023
Richard K. Osborn Lecture
Speaker: Kathryn Huff, US Assistant Secretary for Nuclear Energy

Friday, April 14, 2023
Ethical Applications of AI in International Safeguards
Speaker: Chantell Murphy, Y-12 National Security Complex

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Workshop / Seminar Thu, 30 Mar 2023 19:57:23 -0400 2023-04-07T16:00:00-04:00 2023-04-07T17:00:00-04:00 Cooley Building Nuclear Engineering and Radiological Sciences Workshop / Seminar NERS Winter 2023 Colloquia Series
Tracing molecules through space and time to understand and treat disease (April 13, 2023 3:30pm) https://events.umich.edu/event/107413 107413-21815977@events.umich.edu Event Begins: Thursday, April 13, 2023 3:30pm
Location: Cooley Building
Organized By: Biomedical Engineering

Abstract:
Metabolism is central to virtually all cellular functions and contributes to a range of diseases. A quantitative understanding of how biochemical pathways are dysregulated in the context of diseases such as cancer, metabolic syndrome, and neuropathy is necessary to identify new therapeutic targets. To this end we apply stable isotope tracers, mass spectrometry, and metabolic flux analysis (MFA) to study metabolism in mammalian cells, animal models, and human patients. We are particularly interested in understanding how amino acid and lipid metabolism are coordinated in the context of specific disease states. Serine, glycine and one carbon metabolism is critically important for cell function and health, but the amino acids associated with this pathway are commonly reduced in patients with metabolic syndrome. Here I will detail how we apply MFA and related methods to decipher why serine and glycine are reduced in mouse models of diabetes. At the same time, modulating dietary serine, glycine, and fat impacts lipid metabolism and neuropathy phenotypes in C57BL/6 mice. In turn, supplementation of serine improves sensory function in diabetic animals, suggesting potential therapeutic strategies for treating patients with serine-associated neuropathy. These data provide mechanistic insights into potential drivers diabetes co-morbidities and the role of amino acids in chronic disease. 

Bio:
Christian Metallo is a professor in the Molecular and Cell Biology Laboratory and holds the Daniel and Martina Lewis Chair at the Salk Institute for Biological Studies. He received his BS in chemical engineering from the University of Pennsylvania and his PhD in chemical engineering from the University of Wisconsin-Madison. He completed a postdoctoral fellowship at MIT in chemical engineering studying cancer metabolism before starting his lab in the Bioengineering department at UC San Diego in 2011. He aims to understand how nutrition and metabolism contribute to diseases such as cancer, macular disease and peripheral neuropathy, applying metabolic flux analysis and biochemical engineering approaches to address these questions.

Zoom:
https://umich.zoom.us/j/91712262512

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Workshop / Seminar Sun, 09 Apr 2023 13:05:36 -0400 2023-04-13T15:30:00-04:00 2023-04-13T16:30:00-04:00 Cooley Building Biomedical Engineering Workshop / Seminar BME Seminar Series
Nuclear Safeguards and the He-3 Problem (April 13, 2023 4:00pm) https://events.umich.edu/event/107488 107488-21816098@events.umich.edu Event Begins: Thursday, April 13, 2023 4:00pm
Location: Cooley Building
Organized By: Nuclear Engineering and Radiological Sciences

Speaker Bio:
Richard Kouzes is a Laboratory Fellow Emeritus at the U.S Department of Energy’s Pacific Northwest National Laboratory working in the areas of neutrino science, muon radiography, neutron detection, homeland security, and non-proliferation. His work on homeland security has been for the development and deployment of radioactive material interdiction equipment at U.S. borders, and he was the Principle Investigator and Technical Lead for the U.S. Customs and Border Protection’s Radiation Portal Monitor Project. He is a Fellow of the Institute of Electrical and Electronics Engineers and a Fellow of the American Association for the Advancement of Science. He has been awarded the NPSS Richard F. Shea Distinguished Member Award and the PNNL Director’s Award for Lifetime Achievement.

INMM/IEEE-NPSS will also be hosting a general meeting immediately following Dr. Kouzes' talk (5 PM). Stick around to hear about the organizations' missions and coming events. We will also be holding the elections for new 2023-2024 E-board!

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Workshop / Seminar Tue, 11 Apr 2023 13:34:27 -0400 2023-04-13T16:00:00-04:00 2023-04-13T17:00:00-04:00 Cooley Building Nuclear Engineering and Radiological Sciences Workshop / Seminar portrait of Richard Kouzes
NERS Winter 2023 Colloquia Series (April 14, 2023 4:00pm) https://events.umich.edu/event/100707 100707-21800275@events.umich.edu Event Begins: Friday, April 14, 2023 4:00pm
Location: Cooley Building
Organized By: Nuclear Engineering and Radiological Sciences

For more details, follow the "NERS Colloquia" link to the right. **

Friday, January 6, 2023
CANCELED

Friday, January 13, 2023
Electron Accelerators
Speaker: Bruce Carlsten, Los Alamos National Laboratory

Friday, January 20, 2023
Facility for Rare Isotope Beams and Applications of Nuclear Engineering
Speaker: Takuji Kanemura, Michigan State University

Friday, January 27, 2023
Topic TBA
Speaker: Ling Jian Meng, University of Illinois Urbana-Champaign

Friday, February 3, 2023
Why and How Lightbridge is Developing Advanced Nuclear Fuel
Speaker: Seth Grae, Lightbridge Corporation

Friday, February 10, 2023
Modern Multiscale Kinetic Algorithms for High-Fidelity ICF Capsule and Hohlraum Simulations
Speaker: Luis Chacon, Los Alamos National Laboratory

Friday, February 17, 2023
High-temperature Gas-cooled Reactor Status and Challenges
Speaker: Gerhard Strydom, Idaho National Laboratory

Friday, March 10, 2023
2022 COP Conference Panel
Speaker: Anil Bansal, University of Michigan
Panel Discussion—The November 2022 COP (UN Climate Change) Conference

Friday, March 17, 2023
Speaker: Peter Hotvedt, UM, NERS
Panel Discussion—Student Social Media Presence at the 2022 IAEA Nuclear Power Ministerial Panel

Friday, March 24, 2023
Fuel Design and Developments from a Vendor’s Perspective
Speaker: Jacki Stevens, Framatome

Friday, March 31, 2023
Development of Understandable Artificial Intelligence (UAI) Methods in Physical Sciences
Speaker: Professor Y Z, NERS, U-M

Friday, April 7, 2023
Richard K. Osborn Lecture
Speaker: Kathryn Huff, US Assistant Secretary for Nuclear Energy

Friday, April 14, 2023
Ethical Applications of AI in International Safeguards
Speaker: Chantell Murphy, Y-12 National Security Complex

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Workshop / Seminar Thu, 30 Mar 2023 19:57:23 -0400 2023-04-14T16:00:00-04:00 2023-04-14T17:00:00-04:00 Cooley Building Nuclear Engineering and Radiological Sciences Workshop / Seminar NERS Winter 2023 Colloquia Series
Powder Bed Fusion Laser Beam Metals Additive Manufacturing: Process Monitoring Approaches for Qualification and Certification (May 18, 2023 2:00pm) https://events.umich.edu/event/108142 108142-21818989@events.umich.edu Event Begins: Thursday, May 18, 2023 2:00pm
Location: Cooley Building
Organized By: Nuclear Engineering and Radiological Sciences

Dr. Samuel Hocker is a Structural Materials Engineer in the Advanced Materials and Processing Branch at NASA Langley Research Center. His current research is focused on the statistical process control of powder bed fusion laser beam metal (PBF-LB/M) additive manufacturing. He has led the development of a PBF-LB/M configurable architecture additive testbed, featuring synchronized in-situ process monitoring. His work is part of a larger effort in NASA to accelerate the qualification and certification of additively manufactured parts via computational materials tools and technologies.

The use of in-situ process monitoring is of interest to lower the cost of inspection for the qualification of powder bed fusion laser beam metal (PBF-LB/M) additively manufactured (AM) parts. Precise monitoring of the PBF-LB/M AM build process constitutes a multi-scale and multi-discipline task. There are several significant challenges to the in-situ approach: the synchronization of sensor signals to process steps; the physical interpretation and classification of sensor signals; managing very large datasets; and comparing the inputs with the observed monitoring signals. At NASA Langley Research Center, a configurable architecture additive testbed has been developed to monitor the build process with synchronized sensors. The philosophy and method adopted for the synchronization of the cameras with laser power and position throughout a complex PBF-LB/M AM build will be described. The synchronized in-situ monitoring signals are compared with ex-situ nondestructive inspection, x-ray computed tomography (XCT). Such comparisons permit a better understanding of how the sequential process actions of LPBF-AM can affect build quality.

The multi-scale and complex process of printing additively manufactured (AM) parts can have unexpected, but predictable, build conditions that result in material microstructure variability. This presentation will describe an additive manufacturing model-based process metric (AM-PM) computational method that is a fully parallel reduced order modeling approach developed to evaluate the evolution of AM processes. This method couples the known sequence of the AM process with a physically informed nearest neighbors’ calculation to map the conditions of a part-scale build. The result is a map of the build that is derived directly from build files or in-situ process monitoring sensors. The methodology of the approach will be described and mapped to the porosity observed from XCT for a complex PBF-LB/M build. Such comparative results develop understanding of how the sequential process actions can affect the PBF-LB/M AM build quality and microstructure variability.

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Workshop / Seminar Thu, 18 May 2023 11:43:37 -0400 2023-05-18T14:00:00-04:00 2023-05-18T16:00:00-04:00 Cooley Building Nuclear Engineering and Radiological Sciences Workshop / Seminar portrait of Dr. Samuel Hocker
NERS Colloquium: Departmental Welcome (September 15, 2023 4:00pm) https://events.umich.edu/event/108516 108516-21819883@events.umich.edu Event Begins: Friday, September 15, 2023 4:00pm
Location: Cooley Building
Organized By: Nuclear Engineering and Radiological Sciences

NERS Chair Todd Allen gives an update on departmental happenings.

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Workshop / Seminar Thu, 06 Jul 2023 15:07:22 -0400 2023-09-15T16:00:00-04:00 2023-09-15T17:00:00-04:00 Cooley Building Nuclear Engineering and Radiological Sciences Workshop / Seminar Todd Allen
NERS Colloquium: The Future is Now: the Intersection of Robotics, Cybersecurity, AI, and Advanced Nuclear (September 22, 2023 4:00pm) https://events.umich.edu/event/108517 108517-21819884@events.umich.edu Event Begins: Friday, September 22, 2023 4:00pm
Location: Cooley Building
Organized By: Nuclear Engineering and Radiological Sciences

Abstract:
As nuclear energy expands its capacity and operational scope to meet evolving energy needs and combat climate change, it is essential to reduce operation and maintenance costs to maintain economic viability. While robots have been used in the past for reducing costs through applications such as surveys, their potential in nuclear power plant operations has been under-explored thus far. In this seminar, I will discuss our research integrating machine learning and robotics to develop advanced online monitoring and diagnosis systems which improve operational efficiency and reactor economics. This approach allows for an increase in sensing scope, reduction in human labor, and decreased human exposure to hazardous conditions. By using robots as a new, versatile and mobile sensing platform, this research improves the overall accuracy and effectiveness in identifying and resolving issues within the plant. Additionally, I will highlight our research on nuclear cybersecurity, which addresses pressing challenges in enabling a digital future for the nuclear industry. Join us for an informative discussion on how advanced technology and research is shaping the future of nuclear energy.

Bio:
Dr. Fan Zhang is an Assistant Professor in Mechanical Engineering at the Georgia Institute of Technology. She directs the Intelligence for Advance Nuclear (iFAN) lab in developing research which uses machine learning and AI to optimize nuclear power plant operations and enhance cybersecurity. Dr. Zhang is a Georgia Tech College of Engineering Cybersecurity Fellow. She received her Ph.D. in Nuclear Engineering and a M.S. degree in Statistics from the University of Tennessee, Knoxville in 2019. She is the recipient of the 2021 Ted Quinn Early Career Award from the American Nuclear Society for her contributions in the fields of instrumentation & control and cybersecurity. In 2022, she was awarded the inaugural Distinguished Early Career Award from the U.S. DOE Office of Nuclear Energy for her project “Robot-assisted Online Monitoring, Online Maintenance, and Dynamic Risk Assessment for LWRs and Advanced Reactors”. She has also been selected to the Class of 2023 Volunteer 40 Under 40 for her professional achievements and broad research impact.

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Workshop / Seminar Tue, 19 Sep 2023 13:21:54 -0400 2023-09-22T16:00:00-04:00 2023-09-22T17:00:00-04:00 Cooley Building Nuclear Engineering and Radiological Sciences Workshop / Seminar Fan Zhang, Georgia Tech