Happening @ Michigan https://events.umich.edu/list/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. LSI Diversity Summit Lecture: Aseem Z. Ansari, Ph.D. (October 14, 2019 12:00pm) https://events.umich.edu/event/68027 68027-16986090@events.umich.edu Event Begins: Monday, October 14, 2019 12:00pm
Location: Palmer Commons
Organized By: Life Sciences Institute (LSI)

The Ansari group has pioneered the development of synthetic transcription factors (SynTFs) to control desired gene regulatory networks and guide cell fate choices. In a sense, SynTFs could be viewed as chemical counterparts of the much larger CRISPR-Cas based gene regulators.

Integrating structure-guided design and chemical genomics, the Ansari group created an exciting class of molecules that can rewire epigenetic states at targeted genomic loci. SynTFs designed to reverse repressive epigenetic marks have restored expression of genes whose deficiency causes incurable neuronal diseases such as Friedreich’s ataxia, a progressive neurodegenerative disorder that has no effective therapy. More broadly, SynTFs can be precision-tailored to understand and remedy a wide array of human diseases.

About the Speaker:
Aseem Z. Ansari is the R. J. Ulrich Chair of Chemical Biology and Therapeutics at St. Jude Children’s Research Hospital and the founder of the Khorana and Bose Programs.

Aseem began his scientific career as a summer intern in the laboratory of Obaid Siddiqi at Tata Institute of Fundamental Research (TIFR) in Bombay. That experience led him to graduate studies in Chemical Biology at Northwestern University. Aseem completed his training postdoctoral training as a Helen Hay Whitney Fellow at Harvard University and the Massachusetts Institute of Technology. He was also a resident tutor at the Winthrop House and member of the Board of Tutors in Biochemical Sciences at Harvard. The Ansari Lab works on devising synthetic gene switches that control the fate of human embryonic stem cells and correct gene regulatory networks in neurodegenerative diseases.

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Lecture / Discussion Fri, 04 Oct 2019 13:50:39 -0400 2019-10-14T12:00:00-04:00 2019-10-14T13:00:00-04:00 Palmer Commons Life Sciences Institute (LSI) Lecture / Discussion Aseem Z. Ansari, Ph.D.
RNA Innovation Seminar, Ailong Ke, Cornell University (October 14, 2019 4:00pm) https://events.umich.edu/event/65137 65137-16539448@events.umich.edu Event Begins: Monday, October 14, 2019 4:00pm
Location: Palmer Commons
Organized By: Center for RNA Biomedicine

Ailong Ke PhD, Professor, Department of Molecular Biology and Genetics, Cornell University

Abstract: CRISPR-Cas serves as an RNA-based adaptive immunity system in prokaryotes. The diverse CRISPR systems can be categorized into two major classes and multiple types therein. Type I CRISPR-Cas (or CRISPR-Cas3) belongs to Class 1 and is the most prevalent CRISPR system found in nature. It features a sequential target-searching and degradation process. First, the target-searching complex Cascade (CRISPR associated complex for antiviral defense) uses its guide RNA to find the complementary dsDNA target, and opens a special structure called R-loop at the target site. Its helicase-nuclease fusion enzyme Cas3 is then specifically recruited to the Cascade/R-loop site to processively degrade long-stretches of double-stranded DNA nearby. I will give a comprehensive explanation of CRISPR-Cas3 based interference mechanism, based on the high-resolution biochemistry and structural biology work from my lab. I will further explain CRISPR-Cas3 based genome editing applications, and give perspectives on its therapeutic potential.

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Lecture / Discussion Wed, 25 Sep 2019 10:55:45 -0400 2019-10-14T16:00:00-04:00 2019-10-14T17:00:00-04:00 Palmer Commons Center for RNA Biomedicine Lecture / Discussion flyer
Cholesterol and Phospholipis Metabolism in Physiology and Disease- Annual William E.M. Lands Lectureship in Biological Chemistry (October 15, 2019 12:00pm) https://events.umich.edu/event/67920 67920-16966900@events.umich.edu Event Begins: Tuesday, October 15, 2019 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Peter Tontonoz will deliver the 15th annual William E.M. Lands Lecture on the Biochemical Basis for the Physiology of Essential Nutrients. Dr. Tontonoz is a Professor of Pathology and Laboratory Medicine at the University of California, Los Angeles.

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Lecture / Discussion Wed, 02 Oct 2019 10:37:58 -0400 2019-10-15T12:00:00-04:00 2019-10-15T13:00:00-04:00 Medical Science Unit II Biological Chemistry Lecture / Discussion Tontonoz
How Cell Communication Drives Tissue Form and Function (October 16, 2019 9:30am) https://events.umich.edu/event/67426 67426-16849184@events.umich.edu Event Begins: Wednesday, October 16, 2019 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

2019 Cell & Developmental Biology Seminar Series

Hosted By: Pierre Coulombe, PhD & Kristen Verhey, PhD

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Lecture / Discussion Wed, 18 Sep 2019 15:33:41 -0400 2019-10-16T09:30:00-04:00 2019-10-16T10:30:00-04:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion CDB Seminar - Green
Department of Computational Medicine & Bioinformatics Weekly Seminar (October 16, 2019 4:00pm) https://events.umich.edu/event/68138 68138-17011980@events.umich.edu Event Begins: Wednesday, October 16, 2019 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Talk Title: "3D genome structure as a tool to understand the impact of somatic and germline sequence variants"

Abstract: The 3-dimensional organization of DNA inside of the nucleus impacts a variety of cellular processes, including gene regulation. Furthermore, it is apparent that somatic structural variants that affect how chromatin is organized in 3D can have a major impact on gene regulation and human disease. However, such structural variants in the context of cancer genomes are abundant, and predicting the consequence of any individual somatic mutation on 3D genome structure and gene expression is challenging. In addition, we are severely limited with regard to tools that can be used to study 3D folding of the genome in vivo in actual human tumor or tissue samples. Our lab has developed several approaches to address these challenges. We have taken a pan-cancer approach to identify loci in the genome that are affected by structural variants that alter 3D genome structure, and we have identified numerous loci with recurrent 3D genome altering mutations. We have also used genome engineering to create novel structural variants to better understand what types of mutations are actually capable of altering 3D genome structure and gene regulation. Finally, we have also developed novel tools to study 3D genome structure in vivo in complex tissue samples. We believe that these approaches will be critical for improving our understanding of how non-coding sequence variants can affect 3D genome structure and gene regulation, with the ultimate goal of understanding how these events affect human physiology.

3:45 pm - Light Refreshments Served
4:00 pm - Lecture

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Lecture / Discussion Mon, 07 Oct 2019 16:39:45 -0400 2019-10-16T16:00:00-04:00 2019-10-16T17:00:00-04:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
MCDB Seminar: Monoterpene Volatile Biosynthesis in Rose Scented Geranium (October 18, 2019 12:00pm) https://events.umich.edu/event/67356 67356-16839924@events.umich.edu Event Begins: Friday, October 18, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Eran Pichersky

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Workshop / Seminar Tue, 17 Sep 2019 16:19:55 -0400 2019-10-18T12:00:00-04:00 2019-10-18T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Glandular trichomes Pelargonium graveolens
RNA Innovation Seminar, Ruslan Afasizhev, Boston University Medical Campus (October 21, 2019 4:00pm) https://events.umich.edu/event/65138 65138-16539449@events.umich.edu Event Begins: Monday, October 21, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Ruslan Afasizhev, PhD, Professor, Molecular & Cell Biology, Boston University Medical Campus

Abstract: Parasitic protist Trypanosoma brucei causes African human and animal trypanosomiasis, a spectrum of diseases affecting the population and economy in sub-Saharan Africa. These digenetic hemoflagellates belong to Kinetoplastea, a taxonomic class distinguished by possession of a kinetoplast. This nucleoprotein body contains mitochondrial DNA of two kinds: ~25 maxicircles (each ~23kb) encoding ribosomal RNAs, two guide RNA (gRNAs), ribosomal proteins and subunits of respiratory complexes, and approximately 5000 of ~1kb minicircles bearing the majority of gRNA genes. Relaxed maxicircles and minicircles are interlinked and packed into a dense disc-shaped network by association with histone-like proteins. Both maxicircle and minicircle genomes are transcribed by a phage-like RNA polymerase from multiple promoters into 3′-extended precursors which undergo 3′-5′ exonucleolytic trimming. To function in mitochondrial translation, pre-mRNAs must further proceed through 3′ adenylation, and often gRNA-directed uridine insertion/deletion editing, and 3′ A/U-tailing. Ribosomal and guide RNAs are typically 3′ uridylated. Historically, the fascinating phenomenon of RNA editing has attracted major research efforts, but more recent developments provided insights into pre- and post-edited processing events and identified key players in transforming primary precursors into functional RNAs and regulating their turnover. I will present a forward-looking model that integrates known modalities of mitochondrial RNA metabolism.

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Lecture / Discussion Wed, 25 Sep 2019 10:59:39 -0400 2019-10-21T16:00:00-04:00 2019-10-21T17:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion flyer
"The Causes and Consequences of Human Obesity" (October 22, 2019 10:00am) https://events.umich.edu/event/68210 68210-17026817@events.umich.edu Event Begins: Tuesday, October 22, 2019 10:00am
Location: Taubman Biomedical Science Research Building
Organized By: A. Alfred Taubman Medical Research Institute

Dr. O'Rahilly, considered the preemiment obesity researcher of this generation, is a clinician-scientist at the University of Cambridge in the United Kingdom. He will receive the Taubman Prize for his contribution to new understanding of obesity and metabolic diseases.
The Taubman Institute symposium will kick off with a poster session and continental breakfast at 8:30 a.m. in the BSRB lobby; Dr. O'Rahilly will be awarded the Taubman Prize aware and deliver his keynote from 10 a.m. to noon in the Kahn Auditorium at the BSRB.
All are welcome, no registration is required.

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Lecture / Discussion Wed, 09 Oct 2019 11:37:17 -0400 2019-10-22T10:00:00-04:00 2019-10-22T12:00:00-04:00 Taubman Biomedical Science Research Building A. Alfred Taubman Medical Research Institute Lecture / Discussion Professor Sir Stephen O'Rahilly, 2019 Taubman Prize recipient
Mallosteric Misfolding and Rhomboidal Retrotranslocation: Lessons from Regulated ERAD- Department of Biological Chemistry Seminar (October 22, 2019 12:00pm) https://events.umich.edu/event/67922 67922-16966903@events.umich.edu Event Begins: Tuesday, October 22, 2019 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Randy Hampton, Professor of Biological Sciences at the University of California San Diego, will present the Department of Biological Chemistry Seminar

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Lecture / Discussion Wed, 02 Oct 2019 10:52:11 -0400 2019-10-22T12:00:00-04:00 2019-10-22T13:00:00-04:00 Medical Science Unit II Biological Chemistry Lecture / Discussion Hampton
Prediction Error & Model Evaluation for Space-Time Downscaling: case studies in air pollution during wildfires (October 22, 2019 1:00pm) https://events.umich.edu/event/68191 68191-17026797@events.umich.edu Event Begins: Tuesday, October 22, 2019 1:00pm
Location: Public Health I (Vaughan Building)
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

ABSTRACT:
Public Health Scientists use prediction models to downscale (i.e., interpolate) air pollution exposure where monitoring data is insufficient. This exercise aims to obtain estimates at fine resolutions, so that exposure data may reliably be related to health outcomes. In this setting, substantial research efforts have been dedicated to the development of statistical models capable of integrating heterogenous information to obtain accurate prediction: statistical downscaling models, land use regression, as well as machine learning strategies. However, when presented with the tasks of choosing between models, or averaging models, we find that our understanding of model performance in the absence of independent statistical replications remains insufficient. This lecture is motivated by several studies of air pollution (PM 2.5 and ground-level ozone) during wildfires. We review the basis for cross validation as a strategy for the estimation of the expected prediction error. As these performance measure play a crucial role in model selection and averaging we present a formal characterization of the estimands targeted by different data subsetting strategies, and explore their performance in engineered data settings. A final analysis and a warning about preference inversion is presented in relation to the a 2008 wildfire event in Northern California.

BIO:
Dr. Telesca is Associate Professor of Biostatistics at the University of California Los Angeles. He received a Ph.D. in Statistics from the University of Washington and spent two years at the University of Texas M.D. Anderson Cancer Center as a postdoctoral fellow. His research interests include Bayesian methods in multivariate statistics, functional data analysis, statistical methods in bio- and nano-informatics. Dr. Telesca is a member of the California NanoSystems Institute, the UCLA Jonsson Comprehensive Cancer Center and principal data scientist at Lucid Circuit Inc.

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Lecture / Discussion Wed, 09 Oct 2019 09:51:07 -0400 2019-10-22T13:00:00-04:00 2019-10-22T14:30:00-04:00 Public Health I (Vaughan Building) Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Donatello Telesca Environmental Statistics Day Lecture
Pizza with Professors (October 22, 2019 4:00pm) https://events.umich.edu/event/68576 68576-17103242@events.umich.edu Event Begins: Tuesday, October 22, 2019 4:00pm
Location: Undergraduate Science Building
Organized By: Program in Biology

The Departments of Molecular, Cellular, and Developmental Biology (MCDB) and Ecology and Evolutionary Biology (EEB) invite you to Pizza with Professors! This is an informal time to chat with MCDB and EEB professors about research, courses, and pre-professional studies over a slice of pizza!

Please RSVP here: https://forms.gle/hzpEbWV4SZfpfrkf6

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Careers / Jobs Fri, 18 Oct 2019 09:54:44 -0400 2019-10-22T16:00:00-04:00 2019-10-22T18:00:00-04:00 Undergraduate Science Building Program in Biology Careers / Jobs Join us for Pizza with Professors!
CDB Seminar: Torsin and other nuclear envelope proteins: Structural biology on a roller coaster (October 23, 2019 4:00pm) https://events.umich.edu/event/67428 67428-16849200@events.umich.edu Event Begins: Wednesday, October 23, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

2019 Cell & Developmental Biology Seminar Series

Hosted By: Kristen Verhey, PhD

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Lecture / Discussion Mon, 28 Oct 2019 15:52:52 -0400 2019-10-23T16:00:00-04:00 2019-10-23T17:00:00-04:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion CDB Seminar - Schwartz
Department of Computational Medicine & Bioinformatics Weekly Seminar Series (October 23, 2019 4:00pm) https://events.umich.edu/event/68168 68168-17020453@events.umich.edu Event Begins: Wednesday, October 23, 2019 4:00pm
Location:
Organized By: DCMB Seminar Series

Talk Title: "Chromatin accessibility signatures of immune system aging"

Abstract: Aging is linked to deficiencies in immune responses and increased systemic inflammation. To unravel regulatory programs behind these changes, we profiled peripheral blood mononuclear cells (PBMCs) from young and old individuals (n=77) using ATAC-seq and RNA-seq technologies and analyzed these data via systems immunology tools. First, we described an epigenomic signature of immune system aging, with simultaneous systematic chromatin closing at promoters and enhancers associated with T cell signaling. This signature was primarily borne by memory CD8+ T cells, which exhibited an aging-related loss in IL7R activity and IL7 responsiveness. More recently to uncover the impact of sex on immune system aging, we studied PBMCs from 194 healthy adults (100 women, 94 men) ranging from 22-93 years old using ATAC-seq, RNA-seq, and flow cytometry technologies. These data revealed a shared epigenomic signature of aging between sexes composed of declines in naïve T cell functions and increases in monocyte and cytotoxic cell functions. Despite similarities, these changes were greater in magnitude in men. Additionally, we uncovered male-specific decreases in expression/accessibility of B-cell associated loci. Trajectory analyses revealed that age-related epigenomic changes were more abrupt at two timepoints in the human lifespan. The first timepoint was similar between sexes in terms of timing (early forties) and magnitude. In contrast, the latter timepoint was earlier (~5 years) and more pronounced in men (mid-sixties versus late-sixties). Unexpectedly, differences between men and women PBMCs increased with aging, with men having higher monocyte and pro-inflammatory activity and lower B/T cell activity compared to women after 65 years of age. Our study uncovered which immune cell functions and molecules are differentially affected with age between sexes, including the differences in timing and magnitude of changes, which is an important step towards precision medicine in older adults.

3:45 pm - Light refreshments served
4:00 pm - Lecture

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Lecture / Discussion Tue, 08 Oct 2019 15:12:18 -0400 2019-10-23T16:00:00-04:00 2019-10-23T17:00:00-04:00 DCMB Seminar Series Lecture / Discussion
Science, Technology, and Public Policy Graduate Certificate Info Session (October 23, 2019 4:00pm) https://events.umich.edu/event/67933 67933-16969022@events.umich.edu Event Begins: Wednesday, October 23, 2019 4:00pm
Location: Weill Hall (Ford School)
Organized By: Science, Technology, and Public Policy (STPP) Program

Join us for an information session about the Science, Technology, and Public Policy (STPP) Graduate Certificate!

Wednesday, October 23rd, 4:00pm-5:00pm
5240 Weill Hall
There will be SNACKS!

Do you want to learn how science and technology policy is made? Are you interested in the social and ethical implications of developments like gene editing and autonomous vehicles? Are you concerned about the increased politicization of science and research funding?

In the STPP graduate certificate program, graduate students from across the University analyze the role of science and technology in the policymaking process, gain experience writing for policymakers, and explore the political and policy landscape of areas such as biotechnology, information technology, energy, and others. Graduates of the STPP certificate have gone on to a range of policy-engaged scientific roles in government, NGOs, and academia.

More information about the program is available at: http://stpp.fordschool.umich.edu/graduate-certificate/

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Presentation Wed, 02 Oct 2019 13:21:49 -0400 2019-10-23T16:00:00-04:00 2019-10-23T17:00:00-04:00 Weill Hall (Ford School) Science, Technology, and Public Policy (STPP) Program Presentation Information Session promotional slide
MCDB Seminar: Telomerase RNA Biogenesis: Human Genetics to Therapeutic Prospects (October 25, 2019 12:00pm) https://events.umich.edu/event/67357 67357-16839925@events.umich.edu Event Begins: Friday, October 25, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: JK Nandakumar

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Workshop / Seminar Tue, 17 Sep 2019 16:28:46 -0400 2019-10-25T12:00:00-04:00 2019-10-25T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar micrograph of teleomeres
RNA Innovation Seminar, Luis Batista, Washington University in St. Louis (October 28, 2019 4:00pm) https://events.umich.edu/event/65140 65140-16539450@events.umich.edu Event Begins: Monday, October 28, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Luis Batista, PhD, Assistant Professor of Medicine and Developmental Biology, Washington University in St. Louis

Abstract: The overarching goal of the Batista lab is to understand the regulation and function of telomerase in tissue fitness, disease, and cancer. The Batista laboratory uses genome-wide methods to uncover alterations that drive cellular failure upon critical telomerase dysfunction, using the targeted differentiation of human pluripotent stem cells to tissues of clinical relevance as a primary model. We combine in vitro biochemical and mechanistic studies with our ability to generate and differentiate pluripotent cells towards different fates to better understand the importance of correct ribonucleoprotein assembly and function in tissue fitness and to determine the events that lead from impaired RNA-protein assembly to disease in humans.

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Lecture / Discussion Wed, 25 Sep 2019 11:00:45 -0400 2019-10-28T16:00:00-04:00 2019-10-28T17:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion flyer
CDB Dissertation Defense: Ye Li (October 29, 2019 10:00am) https://events.umich.edu/event/68769 68769-17147156@events.umich.edu Event Begins: Tuesday, October 29, 2019 10:00am
Location: Medical Science Research Building 2
Organized By: Cell & Developmental Biology

“Exploring neuronal heterogeneity in the Drosophila nervous system with novel neurotechnologies.”

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Lecture / Discussion Wed, 23 Oct 2019 13:20:35 -0400 2019-10-29T10:00:00-04:00 2019-10-29T11:00:00-04:00 Medical Science Research Building 2 Cell & Developmental Biology Lecture / Discussion Ye Li Dissertation Seminar
Organelle Relationships in Aging and Disease- Department of Biological Chemistry Seminar (October 29, 2019 12:00pm) https://events.umich.edu/event/67925 67925-16966906@events.umich.edu Event Begins: Tuesday, October 29, 2019 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Adam Hughes, Assistant Professor of Biochemistry at the University of Utah, will be delivering the Department of Biological Chemistry Seminar.

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Film Screening Wed, 02 Oct 2019 11:03:08 -0400 2019-10-29T12:00:00-04:00 2019-10-29T13:00:00-04:00 Medical Science Unit II Biological Chemistry Film Screening Hughes
9th Annual Thomas D. Gelehrter M.D. Lecture in Medical Genetics (October 29, 2019 2:00pm) https://events.umich.edu/event/65874 65874-16662158@events.umich.edu Event Begins: Tuesday, October 29, 2019 2:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Department of Human Genetics

Helen H. Hobbs, M.D., is an Investigator of the Howard Hughes Medical Institute and a Professor of Internal Medicine and Molecular Genetics at the University of Texas Southwestern Medical Center. Among Dr. Hobbs’ honors was her election to the National Academy of Medicine in 2004 and National Academy of Sciences in 2007. She received the Breakthrough Prize in Life Sciences and Passano Award (with Jonathan Cohen) in 2016 and the Harrington Prize for Innovation in Medicine in 2018. Dr. Hobbs is recognized for her contributions to the development of new lipid-lowering strategies by identifying genetic variants of large effect in humans. Importantly, her work created a new strategy using human genetics to identify new therapeutic targets for the treatment of complex cardiovascular and metabolic disorders.

This lecture honors Thomas D. Gelehrter, M.D., active emeritus professor and former Chair of the Department of Human Genetics at the University of Michigan.

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Lecture / Discussion Tue, 27 Aug 2019 16:59:30 -0400 2019-10-29T14:00:00-04:00 2019-10-29T17:00:00-04:00 Taubman Biomedical Science Research Building Department of Human Genetics Lecture / Discussion Dr. Helen H. Hobbs
CDB Seminar - Cargo Receptors in the ER: From Clotting Factors to Cholesterol Regulation (October 30, 2019 9:30am) https://events.umich.edu/event/67430 67430-16849214@events.umich.edu Event Begins: Wednesday, October 30, 2019 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

2019 Cell & Developmental Biology Seminar Series

Hosted By: Doug Engel, PhD

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Lecture / Discussion Mon, 28 Oct 2019 15:55:29 -0400 2019-10-30T09:30:00-04:00 2019-10-30T10:30:00-04:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion CDB Seminar - Ginsburg
Dialogues in Contemporary Thought VII | On the 19th Century (November 1, 2019 3:00pm) https://events.umich.edu/event/68948 68948-17197051@events.umich.edu Event Begins: Friday, November 1, 2019 3:00pm
Location: 202 S. Thayer
Organized By: Department of English Language and Literature

In the midst of Red and Black, one of Stendhal's characters makes a declaration, which can serve as an emblem of the 19th century: “All prudence must be renounced! This century was born to overwhelm everything! We are marching into chaos.” Dialogues in Contemporary Thought VII | On the 19th Century, endeavors to contribute to our understanding of this era, through the work of Profs. Tilottama Rajan and Lucy Hartley, who will present two papers: “Elements of Life: Organizing the Work of John Hunter,” and “Poverty, Progress, and Practicable Socialism: Henrietta Barnett, 1851-1936,” respectively.
For more information, please visit our website: https://ccctworkshop.wordpress.com/ ; or email us at: srdjan@umich.edu

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Lecture / Discussion Tue, 29 Oct 2019 15:37:24 -0400 2019-11-01T15:00:00-04:00 2019-11-01T17:30:00-04:00 202 S. Thayer Department of English Language and Literature Lecture / Discussion Poster for Dialogues in Contemporary Thought VII | On the 19th Century
The Annual Bernard W. Agranoff Lectureship in Neuroscience (November 4, 2019 3:15pm) https://events.umich.edu/event/68666 68666-17136728@events.umich.edu Event Begins: Monday, November 4, 2019 3:15pm
Location: University Hospitals
Organized By: Michigan Neuroscience Institute

This annual lectureship features a pre-eminent neuroscientist and honors Bernard W. Agranoff, a leader in biochemistry and an internationally recognized expert in the neurosciences. Dr. Agranoff is a graduate of the University of Michigan who returned as a faculty member in 1960. He served as the Director of Mental Health Research Institute (now known as the Molecular and Behavioral Neuroscience Institute) from 1985 to 1995 and was the Neuroscience Laboratory Building Director from 1983-2002. His scientific career helped establish that long-term memory formation requires de novo protein synthesis and also enhanced our understanding of the processes involved in nerve regeneration. The Lectureship builds upon a career dedicated to promoting excellence in research, education, and mental health care and is an enduring legacy to those seeking to improve our understanding of the brain and apply that knowledge to help those with brain disorders.

Dr. Richard Huganir is the 2019 Agranoff Lecturer. Dr. Huganir is a Bloomberg Distinguished Professor of Neuroscience and Psychological and Brain Sciences and Director of the Solomon H. Snyder Department of Neuroscience at the Johns Hopkins School of Medicine. His career has focused on synapses in the brain. His research has shown that the regulation of receptor function is a major mechanism for the regulation of neuronal excitability and connectivity in the brain and is critical for many higher brain processes, including learning and memory, and is a major determinant of behavior. Moreover, dysregulation of these mechanisms underlies many neurological and psychiatric diseases including Alzheimer’s, ALS, schizophrenia, autism, intellectual disability, PTSD as well as in chronic pain and drug addiction. Dr. Huganir is a member of the American Academy of Arts and Sciences, the National Institute of Medicine and the National Academy of Sciences.

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Lecture / Discussion Tue, 22 Oct 2019 10:00:19 -0400 2019-11-04T15:15:00-05:00 2019-11-04T16:30:00-05:00 University Hospitals Michigan Neuroscience Institute Lecture / Discussion Dr. Richard Huganir
Mechanisms of Ribosome-Associated Quality Control- Biological Chemistry Seminar (November 5, 2019 12:00pm) https://events.umich.edu/event/68247 68247-17035290@events.umich.edu Event Begins: Tuesday, November 5, 2019 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Sichen Shao, Assistant Professor of Cell Biology at Harvard Medical School, will deliver the weekly Department of Biological Chemistry Seminar on Tuesday November 5th, 2019. Please join us in North Lecture Hall, MS II for this seminar.

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Lecture / Discussion Thu, 10 Oct 2019 07:46:26 -0400 2019-11-05T12:00:00-05:00 2019-11-05T13:00:00-05:00 Medical Science Unit II Biological Chemistry Lecture / Discussion Sichen Shao
Genetics of Invasive Glioblastoma Cells (November 5, 2019 4:00pm) https://events.umich.edu/event/67119 67119-16803020@events.umich.edu Event Begins: Tuesday, November 5, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for Cell Plasticity and Organ Design

2019 – 2020 Center for Organogenesis Seminar Series
Faculty Host: Xing Fan, Ph.D.
For additional information contact: organogenesis@umich.edu

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Lecture / Discussion Fri, 13 Sep 2019 10:08:43 -0400 2019-11-05T16:00:00-05:00 2019-11-05T17:00:00-05:00 Taubman Biomedical Science Research Building Center for Cell Plasticity and Organ Design Lecture / Discussion Genetics of Invasive Glioblastoma Cells
Department of Computational Medicine & Bioinformatics Weekly Seminar (November 6, 2019 4:00pm) https://events.umich.edu/event/68926 68926-17197024@events.umich.edu Event Begins: Wednesday, November 6, 2019 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract: Although central architectures drive robust oscillations, biological clock networks containing the same core vary drastically in their potential to oscillate. What peripheral structures contribute to the variation of oscillation behaviors remains elusive. We computationally generated an atlas of oscillators and found that, while certain core topologies are essential for robust oscillations, local structures substantially modulate the degree of robustness. Strikingly, two key local structures, incoherent inputs and coherent inputs, can modify a core topology to promote and attenuate its robustness, additively. These findings underscore the importance of local modifications besides robust cores, which explain why auxiliary structures not required for oscillation are evolutionarily conserved. We further apply this computational framework to search for structures underlying tunability, another crucial property shared by many biological timing systems to adapt their frequencies to environmental changes.

Experimentally, we developed an artificial cell system to reconstitute mitotic oscillatory processes in water-in-oil microemulsions. With a multi-inlet pressure-driven microfluidic setup, these artificial cells are flexibly adjustable in sizes, periods, various molecular and drug concentrations, energy, and subcellular compartments. Using long-term time-lapse fluorescence microscopy, this system enables high-throughput, single-cell analysis of clock dynamics, functions, and stochasticity, key to elucidating the topology-function relation of biological clocks.

We also investigate how multiple clocks coordinate via biochemical and mechanical signals in the essential developmental processes of early zebrafish embryos (e.g., mitotic wave propagation, synchronous embryo cleavages, and somitogenesis). To pin down the physical mechanisms that give rise to these complex collective phenomena, we integrate mathematical modeling, live embryo and explant imaging, nanofabrication, micro-contact printing, and systems and synthetic biology approaches.

BlueJeans livestream: https://primetime.bluejeans.com/a2m/live-event/rbuvycdc
Qiong Yang: https://medicine.umich.edu/dept/dcmb/qiong-yang-phd

3:45 pm to 4:00 pm - Light refreshments
4:00 pm - Lecture

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Lecture / Discussion Tue, 29 Oct 2019 12:56:42 -0400 2019-11-06T16:00:00-05:00 2019-11-06T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
MCDB Seminar: Cellular Pathways Regulating Early Pollen-Pistil Interactions and Self-Fertility (November 8, 2019 12:00pm) https://events.umich.edu/event/67360 67360-16839926@events.umich.edu Event Begins: Friday, November 8, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Cora MacAlister

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Workshop / Seminar Tue, 17 Sep 2019 16:38:38 -0400 2019-11-08T12:00:00-05:00 2019-11-08T13:00:00-05:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar close up photo of flower with parts labelled
Seminar: Are the North Pacific Chlorophyll Blooms Caused by Breaking Internal Waves? (November 8, 2019 12:00pm) https://events.umich.edu/event/68591 68591-17105347@events.umich.edu Event Begins: Friday, November 8, 2019 12:00pm
Location: 1100 North University Building
Organized By: Earth and Environmental Sciences

The analysis of ocean color satellite data has detected summer blooms of chlorophyll that consistently develop in the oligotrophic North Pacific Ocean between Hawaii and 30°N. In this seminar I will describe the features of these blooms and discuss the potential biological and physical forcing mechanisms that cause them. Based on limited field sampling it appears that these blooms often contain diatom—diazotrophic associations (DDAs). Blooms of both Hemiaulus and Rhizosolenia diatoms, both containing the nitrogen-fixing endophyte Richelia intracellularis, have been sampled within the satellite-defined bloom features. The blooms develop in late summer in a very consistent location, ~30°N, and 130-150°W, and they occur almost every year. The general oceanography principals that explain the global chlorophyll distribution cannot account for these blooms, and their existence suggests evidence of enhanced tidal mixing in this area. The region near 30° is a “double” critical latitude, with a transformation of internal waves occurring at both diurnal and semidiurnal frequencies. The breakdown at the critical latitude of internal waves generated at Hawaii could provide the physical mechanism to explain these blooms. Subsurface data will be also be presented from a Biogeochemical-Argo float that collected data synoptic with the development of a chlorophyll bloom in 2014.

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Workshop / Seminar Fri, 18 Oct 2019 12:13:36 -0400 2019-11-08T12:00:00-05:00 2019-11-08T13:00:00-05:00 1100 North University Building Earth and Environmental Sciences Workshop / Seminar Map-Chlorophyll Concentrations
MCDB Defense: Investigations of the Root Epidermal Cell Specification in Arabidopsis thaliana (November 11, 2019 1:30pm) https://events.umich.edu/event/69127 69127-17250862@events.umich.edu Event Begins: Monday, November 11, 2019 1:30pm
Location: Rackham Graduate School (Horace H.)
Organized By: Department of Molecular, Cellular, and Developmental Biology

Mentor: John Schielfelbein

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Workshop / Seminar Tue, 05 Nov 2019 11:52:54 -0500 2019-11-11T13:30:00-05:00 2019-11-11T15:30:00-05:00 Rackham Graduate School (Horace H.) Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar microscope images and MCDB
RNA Innovation Seminar, Bruce Sullenger, Duke School of Medicine (November 11, 2019 4:00pm) https://events.umich.edu/event/65141 65141-16539451@events.umich.edu Event Begins: Monday, November 11, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Bruce A. Sullenger, Ph.D.
Joseph and Dorothy Beard Professor
Department of Surgery
Professor of Pharmacology and Cancer Biology
Duke University Medical Center

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Lecture / Discussion Thu, 24 Oct 2019 08:30:39 -0400 2019-11-11T16:00:00-05:00 2019-11-11T17:00:00-05:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion flyer
Hypoxia and Mitochondrial Disease: Can Two Wrongs Make a Right?- George William Jourdian Lectureship in Biological Chemistry (November 12, 2019 12:00pm) https://events.umich.edu/event/68289 68289-17043839@events.umich.edu Event Begins: Tuesday, November 12, 2019 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Vamsi Mootha, Professor of Systems Biology at Harvard Medical School and Professor of Medicine at Massachusetts General Hospital, will present the 3rd Annual George William Jourdian Lectureship in Biological Chemistry On Tuesday November 12th, 2019 at 12 noon in North Lecture Hall, MS II

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Lecture / Discussion Fri, 11 Oct 2019 08:37:52 -0400 2019-11-12T12:00:00-05:00 2019-11-12T13:00:00-05:00 Medical Science Unit II Biological Chemistry Lecture / Discussion Mootha
Genomic insights into human cortical development (November 12, 2019 4:00pm) https://events.umich.edu/event/68647 68647-17130514@events.umich.edu Event Begins: Tuesday, November 12, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for Cell Plasticity and Organ Design

2019-2020 Center for Organogenesis Seminar Series
Faculty Host(s): Jack Parent, Ken Kwan, Shigeki Iwase
For additional info contact: organogenesis@umich.edu

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Lecture / Discussion Mon, 21 Oct 2019 12:35:14 -0400 2019-11-12T16:00:00-05:00 2019-11-12T17:00:00-05:00 Taubman Biomedical Science Research Building Center for Cell Plasticity and Organ Design Lecture / Discussion Kriegstein Flyer
CDB Seminar: Defining the role of ER-associated degradation in health and disease (November 13, 2019 9:30am) https://events.umich.edu/event/68707 68707-17138827@events.umich.edu Event Begins: Wednesday, November 13, 2019 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

2019 Cell & Developmental Biology Seminar Series

Hosted By: Qing Li, MD

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Lecture / Discussion Mon, 28 Oct 2019 15:56:34 -0400 2019-11-13T09:30:00-05:00 2019-11-13T10:30:00-05:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion CDB Seminar - Qi
Department of Computational Medicine & Bioinformatics Seminar (November 13, 2019 4:00pm) https://events.umich.edu/event/68641 68641-17128443@events.umich.edu Event Begins: Wednesday, November 13, 2019 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Talk Title: Reproducibility with high-dimensional data

Abstract: With the expanding generation of large-scale biological datasets, there has been an ever-greater concern in understanding the reproducibility of discoveries and findings in a statistically reliable manner. We review several concepts in reproducibility and describe how one can adopt a multiple testing perspective on the problem. This leads to an intuitive procedure for assessing reproducibility. We demonstrate application of the methodology using RNA-sequencing data as well as metabolomics datasets. We will also outline some further problems in the field.

This is joint work with Daisy Philtron, Yafei Lyu and Qunhua Li (Penn State) and Tusharkanti Ghosh, Weiming Zhang and Katerina Kechris (University of Colorado).

DCMB Faculty Host: Alla Karnovsky, PhD

3:45 p.m. - Light Refreshments
4:00 p.m. - Lecture

BlueJeans Live Streaming: https://primetime.bluejeans.com/a2m/live-event/rbuvycdc

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Lecture / Discussion Mon, 21 Oct 2019 11:05:22 -0400 2019-11-13T16:00:00-05:00 2019-11-13T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
MCDB Defense: Functional characterization of selected chloroplast RNA-binding proteins from Arabidopsis thaliana (November 14, 2019 10:00am) https://events.umich.edu/event/69315 69315-17301844@events.umich.edu Event Begins: Thursday, November 14, 2019 10:00am
Location: Rackham Graduate School (Horace H.)
Organized By: Department of Molecular, Cellular, and Developmental Biology

Mentor: Andrzej Wierzbicki, Associate Professor
Molecular, Cellular & Developmental Biology

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Workshop / Seminar Mon, 11 Nov 2019 15:39:28 -0500 2019-11-14T10:00:00-05:00 2019-11-14T12:00:00-05:00 Rackham Graduate School (Horace H.) Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials and yellow drawing of a microscope
LSI Seminar Series: Ronald Raines, Ph.D., Massachusetts Institute of Technology (November 15, 2019 12:00pm) https://events.umich.edu/event/68971 68971-17205311@events.umich.edu Event Begins: Friday, November 15, 2019 12:00pm
Location: Palmer Commons
Organized By: Life Sciences Institute (LSI)

Abstract:

The lipid bilayer that encases human cells has evolved to keep the outside out, and the inside in. This barrier is not, however, impenetrable. Some small molecules, including drugs, can burrow through and manifest therapeutic activities. Others can be “cloaked” to endow membrane permeability, and then uncloaked inside cells. We have learned how to beneficially cloak proteins, which are typically 100-fold larger than small-molecule drugs. Specifically, the conversion of protein carboxyl groups into esters enables the protein to traverse the lipid bilayer. The nascent esters are substrates for endogenous enzymes that regenerate native proteins within cells. The ability to deliver native proteins directly into cells opens a new frontier for medicine.

Speaker:
Ronald Raines, Ph.D.
Firmenich Professor of Chemistry
Massachusetts Institute of Technology

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Lecture / Discussion Wed, 30 Oct 2019 12:59:44 -0400 2019-11-15T12:00:00-05:00 2019-11-15T13:00:00-05:00 Palmer Commons Life Sciences Institute (LSI) Lecture / Discussion LSI Seminar Series
MCDB Seminar: Maps and Neural Codes in Whisker Somatosensory Cortex (November 15, 2019 12:00pm) https://events.umich.edu/event/67361 67361-16839927@events.umich.edu Event Begins: Friday, November 15, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Sam Kwon

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Workshop / Seminar Tue, 17 Sep 2019 16:45:08 -0400 2019-11-15T12:00:00-05:00 2019-11-15T13:00:00-05:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar collage: rat whisker, micrograph, signals
BIONIC Lunch: Precision Health (November 19, 2019 12:00pm) https://events.umich.edu/event/63778 63778-15873596@events.umich.edu Event Begins: Tuesday, November 19, 2019 12:00pm
Location: North Campus Research Complex Building 10
Organized By: The Bioethics Discussion Group

Join us for a lunchtime discussion honing in on the ever truer you.

Please RSVP: https://forms.gle/Zxqo17yGh4PUB46cA

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Lecture / Discussion Mon, 23 Sep 2019 14:00:36 -0400 2019-11-19T12:00:00-05:00 2019-11-19T13:30:00-05:00 North Campus Research Complex Building 10 The Bioethics Discussion Group Lecture / Discussion Precision Health
How to Make RNA Polymerase Processive- Department of Biological Chemistry Seminar (November 19, 2019 12:00pm) https://events.umich.edu/event/68248 68248-17035291@events.umich.edu Event Begins: Tuesday, November 19, 2019 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Irina Artsimovitch, Professor of Microbiology at Ohio State University, will be delivering the weekly Department of Biological Chemistry Seminar on Tuesday 11/19/19 at 12 noon in North Lecture Hall, MS II.

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Lecture / Discussion Thu, 10 Oct 2019 07:54:20 -0400 2019-11-19T12:00:00-05:00 2019-11-19T13:00:00-05:00 Medical Science Unit II Biological Chemistry Lecture / Discussion Artsimovitch
Modular Specification and Regeneration of Jaw Ligaments (November 19, 2019 4:00pm) https://events.umich.edu/event/67120 67120-16803021@events.umich.edu Event Begins: Tuesday, November 19, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for Cell Plasticity and Organ Design

2019 – 2020 Center for Organogenesis Seminar Series
Faculty Host: Kurt Hankenson
For additional information contact: organogenesis@umich.edu

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Lecture / Discussion Mon, 21 Oct 2019 12:15:16 -0400 2019-11-19T16:00:00-05:00 2019-11-19T17:00:00-05:00 Taubman Biomedical Science Research Building Center for Cell Plasticity and Organ Design Lecture / Discussion Crump Flyer
CDB Seminar: Microtubule drugs as medicine (November 20, 2019 9:30am) https://events.umich.edu/event/68705 68705-17138825@events.umich.edu Event Begins: Wednesday, November 20, 2019 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

2019 Cell & Developmental Biology Seminar Series

Hosted By: Ryoma Ohi, PhD & Kristen Verhey, PhD

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Lecture / Discussion Mon, 28 Oct 2019 15:57:49 -0400 2019-11-20T09:30:00-05:00 2019-11-20T10:30:00-05:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion CDB Seminar - Mitchison
DCMB Weekly Seminar (November 20, 2019 4:00pm) https://events.umich.edu/event/68972 68972-17205312@events.umich.edu Event Begins: Wednesday, November 20, 2019 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract: GWAS of neuropsychiatric diseases have identified many loci, however, causal variants often remain unknown. We performed ATAC-seq in human iPSC-derived neurons, and identified thousands of variants affecting chromatin accessibility. Such variants are highly enriched with risk variants of a range of brain disorders. We computationally fine-mapped causal variants and experimentally tested their activities using CRISPRi followed by single cell RNA-seq. Our work provides a framework for prioritizing noncoding disease variants.

The second part of my talk will be focused on genetics of N6-methyladenosine (m6A), a common form of mRNA modification. m6A plays an important role in regulating various aspects of mRNA metabolism in eukaryotes. However, little is known about how DNA sequence variations may affect the m6A modification and the role of m6A in common diseases. We mapped genetic variants associated with m6A levels in 60 Yoruba lymphoblast cell lines. By leveraging these variants, our analysis provides novel insights of mechanisms regulating m6A installation, and downstream effects of m6A on other molecular traits such as translation rate. Integrated analysis with GWAS data reveals m6A variation as an important mechanism linking genetic variations to complex diseases.

BlueJeans livestreaming link: https://primetime.bluejeans.com/a2m/live-event/rbuvycdc

3:45 p.m. - Light Refreshments
4:00 p.m. - Lecture

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Lecture / Discussion Wed, 30 Oct 2019 12:51:34 -0400 2019-11-20T16:00:00-05:00 2019-11-20T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
U.S. Energy Transitions in the Trump Administration (November 21, 2019 12:00pm) https://events.umich.edu/event/69079 69079-17242640@events.umich.edu Event Begins: Thursday, November 21, 2019 12:00pm
Location: Jeffries Hall
Organized By: Michigan Law Environmental and Energy Law Program

Please join us for the latest installment in the ELPP Lecture Series. Professor Alexandra Klass from the University of Minnesota Law School will discuss recent developments in U.S. energy law, policy, economics, and technology. Although President Trump and his cabinet Secretaries, particularly at the Interior Department, Energy Department, and Environmental Protection Agency, have announced dramatic policy shifts away from those pursued during the Obama Administration, the new administration’s ability to accomplish its goals is in some instances helped and in other instances hindered by existing federal and state laws as well as private sector technology and economic trends. Topics will include the shift away from the use of coal and toward natural gas and renewable energy in the electricity sector; the use of federal public lands to develop oil, natural gas, coal, wind, and solar energy; developments in technology and law associated with hydraulic facturing ("fracking"); and controversies over new oil and gas pipelines such as the Dakota Access and Keystone XL Pipelines.

This event is free and open to the public.

Professor Alexandra B. Klass teaches and writes in the areas of energy law, environmental law, natural resources law, tort law, and property law. Her recent scholarly work, published in many of the nation’s leading law journals, addresses regulatory challenges to integrating more renewable energy into the nation’s electric grid, transportation electrification, oil and gas transportation infrastructure, and the use of eminent domain for electric transmission lines and pipelines. She is a co-author of Energy Law: Concepts and Insights Series (Foundation Press 2017), Energy Law and Policy (West Academic Publishing 2d ed. 2018), Natural Resources Law: A Place-Based Book of Problems and Cases (Wolters Kluwer, 4th ed., 2018), and The Practice and Policy of Environmental Law (Foundation Press, 4th ed. 2017). Professor Klass was named the Stanley V. Kinyon Teacher of the Year for 2009-2010, and she served as Associate Dean for Academic Affairs from 2010-2012. She was a Visiting Professor of Law at Harvard Law School in 2015. She is a Distinguished McKnight University Professor and in prior years was the Julius E. Davis Professor of Law and the Solly Robins Distinguished Research Fellow.

Prior to her teaching career, Professor Klass was a partner at Dorsey & Whitney LLP in Minneapolis, where she specialized in environmental law, natural resources, and land use matters. During her years in private practice from 1993-2004, she handled cases in federal and state trial and appellate courts involving contaminated property, wetlands, environmental review, mining, environmental rights, zoning, eminent domain, and environmental torts. She clerked for the Honorable Barbara B. Crabb, Chief Judge of the U.S. District Court for the Western District of Wisconsin from 1992-1993.

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Lecture / Discussion Mon, 04 Nov 2019 09:42:30 -0500 2019-11-21T12:00:00-05:00 2019-11-21T13:00:00-05:00 Jeffries Hall Michigan Law Environmental and Energy Law Program Lecture / Discussion
MCDB: Probing Golgi Apparatus Organization a Rab at a Time (November 22, 2019 12:00pm) https://events.umich.edu/event/67362 67362-16839928@events.umich.edu Event Begins: Friday, November 22, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Yanzhuang Wang

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Workshop / Seminar Mon, 11 Nov 2019 15:31:00 -0500 2019-11-22T12:00:00-05:00 2019-11-22T13:00:00-05:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar micrograph of golgi apparatus
This Podcast Will Kill You: Science communication through conversation (November 22, 2019 2:00pm) https://events.umich.edu/event/69171 69171-17259022@events.umich.edu Event Begins: Friday, November 22, 2019 2:00pm
Location: Palmer Commons
Organized By: Life Sciences Institute (LSI)

Erin Allmann Updyke and Erin Welsh, hosts and creators of "This Podcast Will Kill You," will discuss their experiences with creating a popular science podcast and then delve into a locally relevant disease in a mini-episode format.

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Lecture / Discussion Wed, 06 Nov 2019 11:45:33 -0500 2019-11-22T14:00:00-05:00 2019-11-22T15:00:00-05:00 Palmer Commons Life Sciences Institute (LSI) Lecture / Discussion This Podcast Will Kill You
RNA Innovation Seminar, Kristian Baker, Case Western (November 25, 2019 4:00pm) https://events.umich.edu/event/65142 65142-16541442@events.umich.edu Event Begins: Monday, November 25, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Kristian E. Baker, Ph.D. (Principle Investigator), Center for RNA Molecular Biology, Case Western Reserve University

Abstract: The nonsense-mediated mRNA decay pathway in eukaryotes serves as an RNA quality control system to protect cells from persistent expression of C-terminally truncated polypeptides as a consequence of premature translation termination at nonsense codons. How the cell defines a translation termination event as premature and, subsequently, how this information is communicated to the decay machinery so as to accelerate the degradation of the mRNA remain unclear. We have previously shown that mutations within UPF1 - a member of the SF1 helicase superfamily and a core component of the NMD machinery - which inactivate its ATPase activity give rise to RNA decay intermediates that accumulate due to stalling of ribosomes at or near the premature termination codon. These findings revealed a key functional interaction between the translation apparatus and NMD machinery, and signify that ATP hydrolysis by UPF1 targets the ribosome to facilitate peptide hydrolysis and/or ribosome recycling during translation termination.
My lab’s ongoing efforts directed at dissecting the how UPF1 impacts premature translation termination will be presented.

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Lecture / Discussion Thu, 24 Oct 2019 12:52:12 -0400 2019-11-25T16:00:00-05:00 2019-11-25T17:00:00-05:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion flyer
RNA Innovation Seminar, Auinash Kalsotra, University of Illinois at Urbana-Champaign (December 2, 2019 4:00pm) https://events.umich.edu/event/65143 65143-16541443@events.umich.edu Event Begins: Monday, December 2, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Auinash Kalsotra, PhD, Associate Professor of Biochemistry, Affiliate, Institute for Genomic Biology, University of Illinois at Urbana-Champaign

Abstract: For many genes, steady-state messenger (m)RNA levels provide an inaccurate reflection of the extent to which they are translated into proteins. This seminar will focus on post-transcriptional mechanisms that affect the “quality” and “quantity” of RNAs produced in a cell-type- and context-dependent manner. First, I will describe the identification of a conserved developmentally regulated alternative splicing program that supports terminal differentiation, functional competence, and postnatal maturation of hepatocytes. Second, I will show evidence that following liver injury, this developmental splicing program is transiently re-activated to rewire a critical signaling pathway that enables proper liver regeneration. Third, I will demonstrate that in severe alcoholic hepatitis, the sustained re-activation of this developmental program causes hepatocytes to shed adult functions and become more regenerative but threatens overall survival by populating the liver with functionally-immature cells.

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Lecture / Discussion Thu, 24 Oct 2019 08:55:20 -0400 2019-12-02T16:00:00-05:00 2019-12-02T17:00:00-05:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion flyer
Department of Human Genetics 2019 Seminar Series (December 3, 2019 4:00pm) https://events.umich.edu/event/69796 69796-17425664@events.umich.edu Event Begins: Tuesday, December 3, 2019 4:00pm
Location: Buhl Res Cen for Human Genetics
Organized By: Department of Human Genetics

Dr. Dernburg will be presenting a seminar entitled, "Pairing and Patterning between Meiotic Chromosomes" on Tuesday, December 3, 2019 in the Buhl 5915 Classroom, 1241 Catherine Street, on the medical school campus. The seminar will begin at 4:00 pm, with light refreshments before the start of the seminar.

For more information, call 734-647-3149.






Presented by:





Abby Dernburg, Ph.D.
HHMI Investigator
Department of Molecular and Cell Biology
University of California, Berkeley





Tuesday, December 3, 2019
4:00-5:00 PM
5915 Buhl Classroom

Hosted by: Callie Swanepoel

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Lecture / Discussion Tue, 26 Nov 2019 14:19:16 -0500 2019-12-03T16:00:00-05:00 2019-12-03T17:00:00-05:00 Buhl Res Cen for Human Genetics Department of Human Genetics Lecture / Discussion Buhl Building, 1241 Catherine St.
Mechanisms and consequences of pancreatic cancer stromal evolution (December 3, 2019 4:00pm) https://events.umich.edu/event/68651 68651-17130518@events.umich.edu Event Begins: Tuesday, December 3, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for Cell Plasticity and Organ Design

2019-2020 Center for Organogenesis Seminar Series
Faculty Host(s): Mariana Pasca di Magliano and Howard Crawford
For additional info contact: organogenesis@umich.edu

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Lecture / Discussion Mon, 21 Oct 2019 12:44:53 -0400 2019-12-03T16:00:00-05:00 2019-12-03T17:00:00-05:00 Taubman Biomedical Science Research Building Center for Cell Plasticity and Organ Design Lecture / Discussion Sherman Flyer
MCDB Seminar: In Toto Imaging in Zebrafish Shows How Cells 'Build' Patterns (December 6, 2019 12:00pm) https://events.umich.edu/event/67363 67363-16839929@events.umich.edu Event Begins: Friday, December 6, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Cunming Duan

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Workshop / Seminar Tue, 17 Sep 2019 17:08:59 -0400 2019-12-06T12:00:00-05:00 2019-12-06T13:00:00-05:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar digital image fish embryo
Medical School Inside Story (December 9, 2019 5:00pm) https://events.umich.edu/event/65982 65982-16678385@events.umich.edu Event Begins: Monday, December 9, 2019 5:00pm
Location: University Hospitals
Organized By: Science Learning Center

Do you have questions about medical school admissions? Get your answers straight from the inside! U-M Medical School Admissions Director Carol Teener will demystify medical school applications, expectations, and reviews in her presentation.

Please submit your questions via the following link: https://forms.gle/49SpHo8WZLLfuUuR8 by Monday, December 2 and Director Teener will answer as many commonly-asked questions as possible in the allotted hour.

This session will take place in the University of Michigan Hospital's Ford Auditorium.
We recommend that you leave yourself extra time to find the auditorium if you have not been there before!

Registration Link: http://ttc.iss.lsa.umich.edu/undergrad/sessions/medical-school-inside-story-2/

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Workshop / Seminar Wed, 04 Sep 2019 15:41:30 -0400 2019-12-09T17:00:00-05:00 2019-12-09T18:00:00-05:00 University Hospitals Science Learning Center Workshop / Seminar
Strategies Transcription Factors Use to Target "Inaccessible" DNA -Department of Biological Chemistry Seminar (December 10, 2019 12:00pm) https://events.umich.edu/event/69812 69812-17431797@events.umich.edu Event Begins: Tuesday, December 10, 2019 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Michael Poirier, Professor of Physics at Ohio State University, will present the Department of Biological Chemistry seminar on Tuesday December 10th at 12pm in North Lecture Hall, MS II.

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Workshop / Seminar Wed, 27 Nov 2019 07:29:14 -0500 2019-12-10T12:00:00-05:00 2019-12-10T13:00:00-05:00 Medical Science Unit II Biological Chemistry Workshop / Seminar Michael Poirier
MAGG Mineral Showcase (December 10, 2019 7:00pm) https://events.umich.edu/event/69775 69775-17417493@events.umich.edu Event Begins: Tuesday, December 10, 2019 7:00pm
Location: Michigan League
Organized By: Michigan Association of Geology and Gemology

Come see what the Michigan Association of Geology and Gemology (MAGG) has been up to this semester! We will be showcasing a variety of minerals and gemstones from our collection at 7-9pm in the Koessler Room in the League. The event is open to all and refreshments will be provided.

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Exhibition Mon, 25 Nov 2019 16:25:57 -0500 2019-12-10T19:00:00-05:00 2019-12-10T21:00:00-05:00 Michigan League Michigan Association of Geology and Gemology Exhibition Mineral Showcase Information
BME Seminar: Alexandra Rutz (December 11, 2019 9:00am) https://events.umich.edu/event/69696 69696-17382664@events.umich.edu Event Begins: Wednesday, December 11, 2019 9:00am
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Remarkable advances in medicine and biology have been made possible with bioelectronics – devices that bridge and connect the worlds of living systems and electronics. Bioelectronics include wearable sensors for health monitoring, in vitro diagnostics, therapeutic implantable devices, and electrical stimulation for tissue engineering and regeneration. Despite their influence, bioelectronic devices are still limited by the fact that they are disparate and distinct from biology. The quality of the device-tissue interface is poor and diminishes with time; this is thought to be due to many factors including significant surgical trauma, an aggressive foreign body response, poor material compatibility with the biological milieu, as well as imprecise and distant connections between electronics and surrounding cells or tissues. Towards addressing these challenges, I will first present the use of slippery surfaces for mitigating the consequences of implanting bioelectronics into delicate tissues. I will demonstrate how liquid-infused elastomers reduce tissue deformation and tearing associated with the insertion of intracortical probes in rats. I will then present how, unlike typical electronic fabrication processes, additive manufacturing is compatible with biomaterials and cells. I will demonstrate that when “inks”, processing methods, and scaffold structure are engineered appropriately, extrusion-based 3D printing affords patterned, viable, and functional cell networks, and I will discuss how this can be exploited in future bioelectronic devices. To conclude, I will briefly present my vision to continue tackling the pressing challenges of biointegration that bioelectronics face in expanding their clinical and scientific impacts. The Rutz Lab will engineer “electronic tissues” that merge electronics and biology using additive manufacturing and biomaterials approaches.

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Lecture / Discussion Thu, 21 Nov 2019 10:42:20 -0500 2019-12-11T09:00:00-05:00 2019-12-11T10:00:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Lecture / Discussion BME Logo
CDB Seminar: Molecularly distinct roles of chromatin regulation in cortical development (December 11, 2019 9:30am) https://events.umich.edu/event/69625 69625-17368342@events.umich.edu Event Begins: Wednesday, December 11, 2019 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

2019 Cell & Developmental Biology Seminar Series

Hosted By: Dawen Cai, PhD

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Lecture / Discussion Tue, 19 Nov 2019 17:35:04 -0500 2019-12-11T09:30:00-05:00 2019-12-11T10:30:00-05:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion CDB Seminar - Kwan
Learning Health Sciences Collaboratory Holiday Luncheon (December 12, 2019 12:00pm) https://events.umich.edu/event/69514 69514-17335463@events.umich.edu Event Begins: Thursday, December 12, 2019 12:00pm
Location: Michigan League
Organized By: Department of Learning Health Sciences

The Learning Health System (LHS) Collaboratory is a campus-wide hub for faculty, student and staff interest in LHS initiatives, advancing interdisciplinary research and promoting the development of learning health systems. To learn more about the Collaboratory, please visit: dlhs-umi.ch/lhs-collaboratory.

Join us on December 12th for our final event of 2019 as we get into the holiday spirit with the LHS Collaboratory! Enjoy food, friendship and some interesting updates at the LHS Collaboratory’s holiday luncheon and networking event. Feel free to bring a colleague (or two) who are new to the Collaboratory – the more the merrier! We welcome all members and their guests to celebrate the holiday season with the LHS Collaboratory! This will be an informal event with a short business meeting to bring everyone up to date on LHS developments across the country and around the world.

See you on the 12th!

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Lecture / Discussion Fri, 15 Nov 2019 13:34:25 -0500 2019-12-12T12:00:00-05:00 2019-12-12T13:30:00-05:00 Michigan League Department of Learning Health Sciences Lecture / Discussion Sign for Collaboratory
LSI Seminar Series: Jon Clardy, Ph.D., Harvard Medical School (December 12, 2019 12:00pm) https://events.umich.edu/event/69745 69745-17415369@events.umich.edu Event Begins: Thursday, December 12, 2019 12:00pm
Location: Palmer Commons
Organized By: Life Sciences Institute (LSI)

Abstract:
Numerous studies with varying degrees of statistical power have found correlations between the composition of the bacterial population in the human gut microbiome and disease states. But the molecules and mechanism(s) connecting a dysbiotic microbiome to a specific disease are generally unknown. In an attempt to address this gap, we undertook a series of screens to link bacterial metabolites with diseases like type 1 diabetes (T1D) and inflammatory bowel disease (IBD). We focused on primary drivers of inflammation like TNFα (tumor necrosis factor alpha) produced by human dendritic cells. This seminar will describe our screening logic, the selection of candidate bacterial strains, the discovery of the small molecule regulators of cytokine production, their structures and biosynthesis, and inflammatory mechanism.

About the speaker:
Jon Clardy obtained his B.S. degree from Yale University and his Ph.D. from Harvard University, both in chemistry. He has served on the Chemistry Department faculties of Iowa State University and Cornell University, and he is currently the Hsien Wu & Daisy Yen Wu Professor of Biological Chemistry & Molecular Pharmacology at Harvard Medical School. His research has focused on naturally occurring biologically active small molecules, their macromolecular targets, and their roles in biology and medicine. His current interests involve the molecular underpinnings of complex symbiotic systems involving both prokaryotes and eukaryotes, bacterial influences on animal and plant development, bacterial communications, and the influence of the human gut microbiome on human health and disease. He currently lectures in graduate courses and teaches a Freshman Seminar entitled Psychoactive Molecules from Babylon to Breaking Bad to Harvard undergraduates.

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Lecture / Discussion Mon, 25 Nov 2019 08:34:01 -0500 2019-12-12T12:00:00-05:00 2019-12-12T13:00:00-05:00 Palmer Commons Life Sciences Institute (LSI) Lecture / Discussion LSI Seminar Series
RNA Innovation Seminar, Silvie Rouskin, Whitehead/MIT (December 16, 2019 4:00pm) https://events.umich.edu/event/65144 65144-16541444@events.umich.edu Event Begins: Monday, December 16, 2019 4:00pm
Location: Palmer Commons
Organized By: Center for RNA Biomedicine

Silvie Rouskin, Ph.D., Andria and Paul Heafy Whitehead Fellow, Whitehead/MIT

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Lecture / Discussion Wed, 04 Dec 2019 11:08:39 -0500 2019-12-16T16:00:00-05:00 2019-12-16T17:00:00-05:00 Palmer Commons Center for RNA Biomedicine Lecture / Discussion flyer
Biosciences Initiative Second Annual Community Celebration and Symposium with President Schlissel (December 16, 2019 4:30pm) https://events.umich.edu/event/69140 69140-17252904@events.umich.edu Event Begins: Monday, December 16, 2019 4:30pm
Location: Michigan League
Organized By: Biosciences Initiative

Celebrating progress of the second year and introducing our 2019 Scientific Initiatives and Exploratory awardees.

The Biosciences Initiative is hosting its second annual community celebration, recognizing the progress of the second year and introducing its most recently awarded projects and groups.

Don't miss your opportunity to learn about these exciting proposals and connect with President Schlissel and fellow members of the biosciences community.

The Biosciences Initiative focuses on funding cutting-edge interdisciplinary research, expert faculty hires, and postgraduate education across the biological sciences at U-M.

Reception with free food and beverages will follow. RSVP to attend: https://docs.google.com/forms/d/e/1FAIpQLSeVAaOMh-bXpKiIfeMx5PQFEtjADiogJwEHlGkhVcfiiQGZ9w/viewform?usp=sf_link.

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Conference / Symposium Fri, 13 Dec 2019 12:30:00 -0500 2019-12-16T16:30:00-05:00 2019-12-16T18:30:00-05:00 Michigan League Biosciences Initiative Conference / Symposium bacteria and people graphic
"What is Sleep? Toward a Cellular and Molecular Comprehension of Sleep Neural Dynamics and Functions" (December 17, 2019 12:00pm) https://events.umich.edu/event/70133 70133-17538849@events.umich.edu Event Begins: Tuesday, December 17, 2019 12:00pm
Location: Palmer Commons
Organized By: Department of Molecular, Cellular, and Developmental Biology

Joint seminar with Life Sciences Institute

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Workshop / Seminar Tue, 10 Dec 2019 10:55:25 -0500 2019-12-17T12:00:00-05:00 2019-12-17T13:00:00-05:00 Palmer Commons Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar cartoon drawing of a sleeping cat
CDB Seminar: Normal and Disordered Human Erythropoiesis (December 18, 2019 9:30am) https://events.umich.edu/event/69624 69624-17368341@events.umich.edu Event Begins: Wednesday, December 18, 2019 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

2019 Cell & Developmental Biology Seminar Series

Hosted By: Doug Engel, PhD

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Lecture / Discussion Tue, 19 Nov 2019 17:28:01 -0500 2019-12-18T09:30:00-05:00 2019-12-18T10:30:00-05:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion CDB Seminar - Narla
Linking Transcriptome with Morphology in Single Cells via Dynamic Developmental Recording (January 6, 2020 9:30am) https://events.umich.edu/event/70364 70364-17586192@events.umich.edu Event Begins: Monday, January 6, 2020 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

A joint seminar with the Life Sciences Institute

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Workshop / Seminar Mon, 16 Dec 2019 15:30:55 -0500 2020-01-06T09:30:00-05:00 2020-01-06T10:30:00-05:00 Taubman Biomedical Science Research Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Drosophila brain cell imaging
RNA Innovation Seminar, David Mathews, University of Rochester (January 13, 2020 4:00pm) https://events.umich.edu/event/65145 65145-16541445@events.umich.edu Event Begins: Monday, January 13, 2020 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

David Mathews , MD, PhD, Professor, Department of Biochemistry & Biophysics, University of Rochester

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Lecture / Discussion Tue, 17 Dec 2019 16:03:20 -0500 2020-01-13T16:00:00-05:00 2020-01-13T17:00:00-05:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion flyer
Heterochromatin Organization and Dynamics- Department of Biological Chemistry Seminar (January 14, 2020 12:00pm) https://events.umich.edu/event/70990 70990-17766487@events.umich.edu Event Begins: Tuesday, January 14, 2020 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Serena Sanulli, Postdoctoral Fellow in the Department of Pharmaceutical Chemistry at UCSF, will give a seminar in the Department of Biological Chemistry on Tuesday 1/14/20 at 12:00pm in North Lecture Hall, MS II.

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Workshop / Seminar Tue, 07 Jan 2020 06:42:55 -0500 2020-01-14T12:00:00-05:00 2020-01-14T13:00:00-05:00 Medical Science Unit II Biological Chemistry Workshop / Seminar Sanulli
“Evolution of vertebrate gill covers through shifts in an ancient gnathostome Pou3f3 enhancer" (January 14, 2020 4:00pm) https://events.umich.edu/event/71205 71205-17785645@events.umich.edu Event Begins: Tuesday, January 14, 2020 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for Cell Plasticity and Organ Design

The NIH T32 Training Program in Organogenesis is pleased to present a Special Series: "Emerging Topics in Tissue Regeneration and Engineering" featuring seminar guest Lindsey Barske, Ph.D.

Dr. Barske is an Assistant Professor, Divisions of Human Genetics & Developmental Biology, Cincinnati Children’s Hospital

The talk is entitled, “Evolution of vertebrate gill covers through shifts in an ancient gnathostome Pou3f3 enhancer”.

Trainee Host: Martha Echevarria-Andino, Ph.D. Candidate-Allen Lab

For additional info: 936-2499 / organogenesis@umich.edu

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Lecture / Discussion Thu, 09 Jan 2020 16:24:44 -0500 2020-01-14T16:00:00-05:00 2020-01-14T17:00:00-05:00 Taubman Biomedical Science Research Building Center for Cell Plasticity and Organ Design Lecture / Discussion Dr. Barske Seminar Flyer
CDB Seminar: Developmental vs Neoplastic Invasion Programs In Vivo: Insights from Branching Morphogenesis and Metastasis (January 15, 2020 9:30am) https://events.umich.edu/event/70640 70640-17611225@events.umich.edu Event Begins: Wednesday, January 15, 2020 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

2020 Cell & Developmental Biology Seminar Series

Hosted By: Doug Engel, PhD

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Lecture / Discussion Thu, 19 Dec 2019 15:27:34 -0500 2020-01-15T09:30:00-05:00 2020-01-15T10:30:00-05:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion CDB Seminar - Weiss
Pharmacology Seminar Series (January 15, 2020 12:00pm) https://events.umich.edu/event/71115 71115-17777081@events.umich.edu Event Begins: Wednesday, January 15, 2020 12:00pm
Location: Taubman Library
Organized By: Michigan Pharmacology

Kellie Machlus, Assistant Professor, BWH Hematology Division, Harvard Institutes of Medicine

"Novel Mechanisms by which Megakaryocytes Regulate Platelet Production in Health and Inflammatory Disease"

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Workshop / Seminar Wed, 08 Jan 2020 15:22:22 -0500 2020-01-15T12:00:00-05:00 2020-01-15T13:00:00-05:00 Taubman Library Michigan Pharmacology Workshop / Seminar Machlus seminar
DCMB Weekly Seminar (January 15, 2020 4:00pm) https://events.umich.edu/event/70964 70964-17760238@events.umich.edu Event Begins: Wednesday, January 15, 2020 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract: Synchronization occurs all around us. It underlies how fireflies flash as one, how human heart cells beat in unison, and how superconductors conduct electricity with no resistance. Synchronization is present in the precision of the cell cycle, and we can explore how breakdown of precision leads to disease. The many unique and fundamental functions of different cell types are achieved over and over independently, through a form of synchronization involving choreography of many proteins and genes. I will share a general historic and descriptive introduction to synchrony, including the classic work of Alan Turing. I will present some new work done jointly with Cleve Moler (MathWorks) and Steve Smale (UC Berkeley), where biology has inspired us to build new mathematical techniques to explore synchrony and its breakdown.

BlueJeans Livestream: https://primetime.bluejeans.com/a2m/live-event/rbuvycdc

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Lecture / Discussion Mon, 06 Jan 2020 15:39:08 -0500 2020-01-15T16:00:00-05:00 2020-01-15T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
Being Human in STEM: An Experiment in Partnering with Students to Address Issues of Equity in STEM (January 16, 2020 12:00pm) https://events.umich.edu/event/69259 69259-17275351@events.umich.edu Event Begins: Thursday, January 16, 2020 12:00pm
Location: Rackham Graduate School (Horace H.)
Organized By: LSA Biophysics

When student protesters occupied the Amherst College library for four days in November of 2015, the campus community was transfixed by the painful testimonials shared by marginalized students about their experiences at Amherst as individuals identifying as Black, brown, female, queer, trans, disabled, international, among others. In response to letters from a Black neuroscience major and a non-binary biochemistry and biophysics major, every STEM department wrote a letter of support, pledging to work with students to address their concerns. The following semester, Chemistry professor Sheila Jaswal collaborated with students to develop a project-based course, titled “Being Human in STEM” (HSTEM), to actively engage STEM students and departments in learning about and enhancing inclusion in STEM settings. Now in its sixth iteration, students drive the academic inquiry, investigating both the local experience and the literature on diversity in STEM. They then use that research to design tools and interventions to share with and enhance their own STEM community.  In this seminar, Professor Jaswal will describe how HSTEM course projects and activities have continued the conversation started by students during the Uprising, connected STEM inclusion efforts across the Amherst campus, and produced resources such as the “Inclusive Curricular Practices” handbook, that have been used by STEM educators from high schools, colleges, universities, and the Howard Hughes Medical Institute Inclusive Excellence institutions. She will present evidence on the impact of the HSTEM course and practices on students, faculty and staff at Amherst, and provide examples of how a growing network of institutions, including Yale, Brown, Williams, and the University of Utah, are adapting the HSTEM model to their own STEM community needs. 

Please visit website for more information on speaker: http://www.beinghumaninstem.com/sheila-jaswal.html

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Workshop / Seminar Wed, 08 Jan 2020 12:58:03 -0500 2020-01-16T12:00:00-05:00 2020-01-16T14:00:00-05:00 Rackham Graduate School (Horace H.) LSA Biophysics Workshop / Seminar Rackham Graduate School (Horace H.)
Taubman Tech Talk: DNA Methylation (January 16, 2020 5:00pm) https://events.umich.edu/event/71321 71321-17817081@events.umich.edu Event Begins: Thursday, January 16, 2020 5:00pm
Location:
Organized By: A. Alfred Taubman Medical Research Institute

pigenetic modifications are important drivers of development, health, and disease. DNA methylation is one type of epigenetic mark that can be measured in blood or other human samples. DNA methylation marks are associated with genetics and environmental exposures, which represents a useful tool for public health and medicine.

This presentation will give an overview of current technologies for DNA methylation measurements, describe methodological challenges associated with these methods, and provide evidence-based opportunities for future DNA methylation studies.

Kelly M. Bakulski, Ph.D. is an Assistant Professor in the Department of Epidemiology at the University of Michigan School of Public Health. Dr. Bakulski’s research goal is to understand the environmental and genetic etiologies of neurological disorders, including autism spectrum disorder and Alzheimer’s disease.

Dr. Bakulski incorporates population approaches and laboratory experiments to develop biomarker and cell type tools to better inform epigenetic inferences.

CME credit is available to physicians.

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Lecture / Discussion Mon, 13 Jan 2020 08:57:27 -0500 2020-01-16T17:00:00-05:00 2020-01-16T18:00:00-05:00 A. Alfred Taubman Medical Research Institute Lecture / Discussion Kelly Bakulski, PhD
CDB Seminar: Fat tissue development, renewal and remodeling (January 21, 2020 9:30am) https://events.umich.edu/event/70942 70942-17758099@events.umich.edu Event Begins: Tuesday, January 21, 2020 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

2020 Cell & Developmental Biology Seminar Series

Hosted By: Pierre Coulombe, Ph.D. and Ben Allen, Ph.D.

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Lecture / Discussion Mon, 06 Jan 2020 11:13:23 -0500 2020-01-21T09:30:00-05:00 2020-01-21T10:30:00-05:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion CDB Seminar - Seale
Fluorescence Microscopy Tools to Illuminate RNA and Protein Dynamics in Live Cells (Department of Biological Chemistry Seminar) (January 21, 2020 12:00pm) https://events.umich.edu/event/71069 71069-17774925@events.umich.edu Event Begins: Tuesday, January 21, 2020 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Esther Braselmann, Postdoctoral Fellow at the University of Colorado Boulder, will be presenting the Department of Biological Chemistry Seminar on Tuesday 1/21/2020 at 12 noon in North Lecture Hall, MS II

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Workshop / Seminar Wed, 08 Jan 2020 07:18:32 -0500 2020-01-21T12:00:00-05:00 2020-01-21T13:00:00-05:00 Medical Science Unit II Biological Chemistry Workshop / Seminar
Understanding Complexity (January 21, 2020 1:00pm) https://events.umich.edu/event/70492 70492-17600719@events.umich.edu Event Begins: Tuesday, January 21, 2020 1:00pm
Location: Off Campus Location
Organized By: Osher Lifelong Learning Institute (50+)

The course will cover complexity science, introducing the core concepts and discussing ideas such as emergence, using twelve DVD lectures from the Teaching Company by University of Michigan Professor Scott Page. We’ll view two 30-minute lectures per class, each followed by 20 minutes for questions and discussion. The study group leader worked 27 years as a research physicist for Ford and taught physics at several levels, including graduate level at Wayne State University. At OLLI, he has taught 16 physics-related classes. The Study Group for those 50 and over led by Richard Chase is held Tuesdays January 21 through February 25.

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Class / Instruction Wed, 18 Dec 2019 11:55:36 -0500 2020-01-21T13:00:00-05:00 2020-01-21T15:00:00-05:00 Off Campus Location Osher Lifelong Learning Institute (50+) Class / Instruction Study Group
Pharmacology Seminar Series (January 22, 2020 12:00pm) https://events.umich.edu/event/71200 71200-17785638@events.umich.edu Event Begins: Wednesday, January 22, 2020 12:00pm
Location: Taubman Library
Organized By: Michigan Pharmacology

Rong Chen, Ph.D., Assistant Professor, Department of Physiology & Pharmacology, Wake Forest School of Medicine

"RGS2 Regulates Dopamine Transmission and Drug Self-administration via Controlling Dopamine D2 Autoreceptors”

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Workshop / Seminar Thu, 09 Jan 2020 15:49:59 -0500 2020-01-22T12:00:00-05:00 2020-01-22T13:00:00-05:00 Taubman Library Michigan Pharmacology Workshop / Seminar Rong Chen Talk
Growth and Grit - Developing a Mindset For Success (January 22, 2020 5:30pm) https://events.umich.edu/event/70897 70897-17735191@events.umich.edu Event Begins: Wednesday, January 22, 2020 5:30pm
Location: Undergraduate Science Building
Organized By: Science Learning Center

What if your ability to succeed in your classes was determined in part before you even stepped into the classroom? What is the one quality you need to overcome adversity academically and in life? This workshop will detail the research of Dr. Carol Dweck and her groundbreaking work on the concept of mindset. Students will learn how to abandon a debilitating fixed mindset in favor of a growth mindset, leading to success in areas they once considered too difficult. The workshop will also introduce students to the research of Dr. Angela Duckworth, and how a growth mindset can lead to the development of grit, an essential characteristic to overcoming our fear of failure.

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Workshop / Seminar Wed, 15 Jan 2020 10:16:28 -0500 2020-01-22T17:30:00-05:00 2020-01-22T19:00:00-05:00 Undergraduate Science Building Science Learning Center Workshop / Seminar
LSI Seminar Series: Wen-Xing Ding, Ph.D., University of Kansas Medical Center (January 23, 2020 12:00pm) https://events.umich.edu/event/70179 70179-17540934@events.umich.edu Event Begins: Thursday, January 23, 2020 12:00pm
Location: Palmer Commons
Organized By: Life Sciences Institute (LSI)

Abstract:
Liver cells can adapt and protect themselves in response to stress by activating cellular protective mechanisms such as autophagy, which is a lysosomal degradation pathway that degrades cellular organelles and/or proteins as well as lipids inside the autolysosomes. To meet the needs of autophagic degradation, it is critical to maintain sufficient numbers of lysosomes to fuse with autophagosomes that form autolysosomes. Lysosomal biogenesis is regulated by the transcription factor EB (TFEB), which is a master transcription regulator of lysosomal biogenesis and autophagy.

Studies from our lab revealed that TFEB is impaired in alcoholic hepatitis and pancreatitis as well as in acetaminophen-induced liver injury. Overexpression of TFEB protects against alcohol and drug-induced tissue damage whereas deletion of TFEB exacerbates tissue damage. Studies from our lab also demonstrated that Nrf2, a transcription factor regulating antioxidant response, promotes liver injury and liver tumorigenesis in autophagy defective livers. More recently, our work suggests that both hyper- and hypo-activation of MTOR are detrimental to the liver resulting in the development of liver tumors. Together, our studies indicate that autophagy and lysosome play critical roles in maintaining liver homeostasis. Approaches to boost autophagy and TFEB pathways, which are often impaired in chronic liver diseases, may be promising for treating and preventing liver disease including alcoholic and non-alcoholic fatty liver diseases, drug-induced liver injury and liver tumorigenesis.

About the Speaker:
Wen-Xing Ding is a professor in the Department of Pharmacology, Toxicology and Therapeutics at The University of Kansas Medical Center. He received his Ph.D. from the National University of Singapore in 2002 and completed his postdoctoral training at the University of Pittsburgh. Ding has devoted his research career to elucidating mechanisms for regulation of cell death and the adaptive response to cellular injury in the liver. Since 2009, his laboratory has been working on the role of autophagy in alcohol- and drug-induced liver injury. They are particularly interested in how autophagy selectively removes cellular damaged/excess organelles, such as mitochondria and lipid droplets in hepatocytes. Ding has published more than 120 papers in peer-reviewed journals, and his work is currently supported by NIAAA and NIDDK.

In addition to research, Ding has demonstrated outstanding leadership for service. He has been a program committee member of ASIP (American Society of Investigative Pathology) and the AASLD (American Association for the Studies of Liver Disease) 2015 annual meeting. He organized several meetings and symposia for EB meeting, AASLD and GRC. He serves as an associate editor for the journal Autophagy and an editorial board member for several journals, including Hepatology, Cell and the American Journal of Pathology. He also serves as an ad hoc reviewer for NIH grants and a standing member of XNDA.

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Lecture / Discussion Wed, 11 Dec 2019 08:27:09 -0500 2020-01-23T12:00:00-05:00 2020-01-23T13:00:00-05:00 Palmer Commons Life Sciences Institute (LSI) Lecture / Discussion LSI Seminar Series
Global, Organism-Scale Views of Cell State Heterogeneity & Dynamics Via Novel Single Cell Profiling Techniques (January 27, 2020 11:00am) https://events.umich.edu/event/71734 71734-17877249@events.umich.edu Event Begins: Monday, January 27, 2020 11:00am
Location: Palmer Commons
Organized By: Cell & Developmental Biology

CDB Faculty Candidate Seminar: Global, Organism-Scale Views of Cell State Heterogeneity & Dynamics Via Novel Single Cell Profiling Techniques

Hosted by: CDB Recruitment Committee & the Department of Human Genetics

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Lecture / Discussion Mon, 20 Jan 2020 09:27:44 -0500 2020-01-27T11:00:00-05:00 2020-01-27T12:00:00-05:00 Palmer Commons Cell & Developmental Biology Lecture / Discussion Global, Organism-Scale Views of Cell State Heterogeneity & Dynamics Via Novel Single Cell Profiling Techniques - Junyue Cao, Ph.D
“Overcoming biological barriers to nucleic acid delivery” (January 28, 2020 4:00am) https://events.umich.edu/event/71237 71237-17794025@events.umich.edu Event Begins: Tuesday, January 28, 2020 4:00am
Location: Taubman Biomedical Science Research Building
Organized By: Center for Cell Plasticity and Organ Design

The NIH T32 Training Program in Organogenesis is pleased to present a Special Series: "Emerging Topics in Tissue Regeneration and Engineering" featuring seminar guest Micheal J. Mitchell, Ph.D.

Dr. Mitchell is a Skirkanich Assistant Professor of Innovation, Department of Bioengineering from the University of Pennsylvania.

The talk is entitled, “Overcoming biological barriers to nucleic acid delivery”.

Trainee Host: Sajedeh Nasr Esfahani, Ph.D. Candidate-Jianping Fu Lab

For additional info: 936-2499 / organogenesis@umich.edu

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Lecture / Discussion Fri, 10 Jan 2020 12:00:47 -0500 2020-01-28T04:00:00-05:00 2020-01-28T05:00:00-05:00 Taubman Biomedical Science Research Building Center for Cell Plasticity and Organ Design Lecture / Discussion Mitchell Seminar Flyer
Investigating Protein Degradation at the Interface of Chemistry and Biology (January 28, 2020 11:45am) https://events.umich.edu/event/70908 70908-17735213@events.umich.edu Event Begins: Tuesday, January 28, 2020 11:45am
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Faculty Candidate
Host: U. Jakob

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Workshop / Seminar Fri, 24 Jan 2020 13:28:03 -0500 2020-01-28T11:45:00-05:00 2020-01-28T12:45:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials on blue background
Pharmacology Seminar Series (January 29, 2020 12:00pm) https://events.umich.edu/event/71201 71201-17785639@events.umich.edu Event Begins: Wednesday, January 29, 2020 12:00pm
Location: Taubman Library
Organized By: Michigan Pharmacology

Eric Small, Ph.D., Associate Professor of Medicine, Cardiovascular Research Institute, University of Rochester Medical Center

“Transcriptional regulation of fibroblast plasticity and cardiac fibrosis”

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Workshop / Seminar Thu, 09 Jan 2020 15:55:46 -0500 2020-01-29T12:00:00-05:00 2020-01-29T13:00:00-05:00 Taubman Library Michigan Pharmacology Workshop / Seminar Small talk
DCMB Seminar Series (January 29, 2020 4:00pm) https://events.umich.edu/event/71998 71998-17911963@events.umich.edu Event Begins: Wednesday, January 29, 2020 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Talk Title: Experimental and computational strategies to aid compound identification and quantitation in metabolomics

Abstract: Over the past two decades, metabolomics as a technique has moved from the primary domain of analytical chemists to more widespread acceptance by biologists, clinicians and bioinformaticians alike. Metabolomics offers systems-level insights into the critical roles small molecules play in routine cellular processes and myriad disease states. However, certain unique analytical challenges remain prominent in metabolomics as compared to the other ‘omics sciences. These include the difficulty of identifying unknown features in untargeted metabolomics data, and challenges maintaining reliable quantitation within lengthy studies that may span multiple laboratories. Unlike genomics and transcriptomics data in which nearly every quantifiable feature is confidently identified as a matter of course, in typical untargeted metabolomics studies over 80% of features are frequently not mapped to a specific chemical compound. Further, although many metabolomics studies have begun to stretch over a timeframe of years, data quantitation and normalization strategies have not always kept up with the requirements for such large studies. Fortunately, both experimental and computational strategies are emerging to tackle these long-standing challenges. We will report on several techniques in development in our laboratory, ranging from chromatographic fractionation and high-sensitivity data acquisition, to computational strategies to aid in tandem mass spectrometric spectral interpretation. These developments serve to facilitate analysis for both experts and novice users, which should ultimately help improve the biological insight and impact gained from metabolomics data.

BlueJeans livestreaming link: https://primetime.bluejeans.com/a2m/live-event/rbuvycdc

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Lecture / Discussion Fri, 24 Jan 2020 11:07:13 -0500 2020-01-29T16:00:00-05:00 2020-01-29T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
Global Insights into Brain Diversity, Development, and Lineage at Single-Cell Resolution (January 30, 2020 11:45am) https://events.umich.edu/event/70909 70909-17735214@events.umich.edu Event Begins: Thursday, January 30, 2020 11:45am
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Faculty Candidate
Host: C. Duan

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Workshop / Seminar Fri, 24 Jan 2020 13:26:23 -0500 2020-01-30T11:45:00-05:00 2020-01-30T12:45:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials and yellow microscope on blue background
BME 500: Meghan Driscoll, Ph.D. (January 30, 2020 4:00pm) https://events.umich.edu/event/70418 70418-17594468@events.umich.edu Event Begins: Thursday, January 30, 2020 4:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Signaling is governed not only by the expression levels of molecules, but by their localization via mechanisms as diverse as compartmentalization in organelles, phase separation, and directed transport by motor proteins. Cell morphology likely also modulates the localization of signaling molecules, and recent advances in high-resolution light-sheet microscopy, such as lattice light-sheet microscopy, now allow imaging at the spatiotemporal resolution needed to capture the many undulations and quick dynamics of the 3D cell surface. However, these microscopes generate large datasets with detailed 3D movies that are impossible to interpret without a dedicated computational pipeline. In this seminar, I will introduce u-shape3D, a computer graphics and machine-learning pipeline to probe molecular mechanisms underlying 3D cell morphogenesis. U-shape3D includes a generic morphological motif detector that automatically finds lamellipodia, filopodia, blebs and other motifs in order to test the intriguing possibility that morphogenesis itself affects intracellular signaling.

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Lecture / Discussion Thu, 23 Jan 2020 11:24:58 -0500 2020-01-30T16:00:00-05:00 2020-01-30T17:00:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Lecture / Discussion BME Logo
MCDB Remembering the past and rewiring the future: A protein-based inheritance paradigm (February 4, 2020 11:45am) https://events.umich.edu/event/70910 70910-17735215@events.umich.edu Event Begins: Tuesday, February 4, 2020 11:45am
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Faculty Candidate
Host: R. Stockbridge

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Workshop / Seminar Fri, 24 Jan 2020 13:31:02 -0500 2020-02-04T11:45:00-05:00 2020-02-04T12:45:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials and yellow microscope on blue background
RNA Regulation at the Single Molecule Level: From Nuclear Organizations to Molecular Activity- Biological Chemistry Seminar (February 4, 2020 12:00pm) https://events.umich.edu/event/71322 71322-17817082@events.umich.edu Event Begins: Tuesday, February 4, 2020 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Fangyuan Ding, Postdoctoral Fellow at CalTech in the Department of Biology and Biological Engineering, will be presenting the Department of Biological Chemistry seminar on Tuesday February 4th, 2020 at 12pm in North Lecture Hall, MS II.

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Workshop / Seminar Mon, 13 Jan 2020 09:11:30 -0500 2020-02-04T12:00:00-05:00 2020-02-04T13:00:00-05:00 Medical Science Unit II Biological Chemistry Workshop / Seminar Ding Flyer
Science as Art Contest Submission Deadline (February 5, 2020 11:55am) https://events.umich.edu/event/48786 48786-17963888@events.umich.edu Event Begins: Wednesday, February 5, 2020 11:55am
Location: Hatcher Graduate Library
Organized By: Arts at Michigan

Arts at Michigan, ArtsEngine and the Science Learning Center invite you to submit artwork to the 2020 Science as Art exhibition. University of Michigan undergraduate students are invited to submit artwork expressing a scientific principle(s), concept(s), idea(s), process(es), and/or structure(s). The artwork may be visual, literary, musical, video, or performance based. A juried panel using criteria based on both scientific and artistic considerations will choose winning submissions.

Deadline for submissions is Wednesday February 5th!

A number of submissions will be selected for prizes, some of which will be on display and/or performed during the Awards Ceremony and/or displayed in an online Contest Gallery. The entry selected for “Best Overall” will be awarded a cash prize, with smaller cash awards in other categories.

For full information, visit: tinyurl.com/scienceasart2020

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Exhibition Thu, 30 Jan 2020 11:47:29 -0500 2020-02-05T11:55:00-05:00 2020-02-05T23:59:00-05:00 Hatcher Graduate Library Arts at Michigan Exhibition Science as Art logo
Synapse instability and degeneration: Mechanisms (February 5, 2020 12:00pm) https://events.umich.edu/event/72328 72328-17974681@events.umich.edu Event Begins: Wednesday, February 5, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Cathy Collins
Yogesh Wairkar is a collaborator with her group.

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Workshop / Seminar Fri, 31 Jan 2020 14:01:48 -0500 2020-02-05T12:00:00-05:00 2020-02-05T13:00:00-05:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials and microscope
Applications of brain-model technology to study neurodevelopmental disorders (February 6, 2020 9:30am) https://events.umich.edu/event/71730 71730-17877246@events.umich.edu Event Begins: Thursday, February 6, 2020 9:30am
Location: Palmer Commons
Organized By: Cell & Developmental Biology

We are pleased to welcome Cleber Trujillo, Ph.D., to Palmer Commons - Great Lakes South on Thursday, February 6th, 2020.

Hosted by: CDB Recruitment Committee

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Lecture / Discussion Mon, 03 Feb 2020 09:39:56 -0500 2020-02-06T09:30:00-05:00 2020-02-06T10:30:00-05:00 Palmer Commons Cell & Developmental Biology Lecture / Discussion Applications of brain-model technology to study neurodevelopmental disorders - Cleber Trujillo, Ph.D
Temporal Regulation of the Blood-Brain Barrier (February 6, 2020 11:45am) https://events.umich.edu/event/70911 70911-17735216@events.umich.edu Event Begins: Thursday, February 6, 2020 11:45am
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Faculty Candidate
Host: G. Csankovszki & Wilinski

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Workshop / Seminar Fri, 24 Jan 2020 13:28:56 -0500 2020-02-06T11:45:00-05:00 2020-02-06T12:45:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials and yellow microscope on blue background
Surfing the Secretory Pathway (February 6, 2020 3:00pm) https://events.umich.edu/event/72331 72331-17974682@events.umich.edu Event Begins: Thursday, February 6, 2020 3:00pm
Location: Palmer Commons
Organized By: Department of Molecular, Cellular, and Developmental Biology

Scientist working on Golgi membrane trafficking
This is an event from the Protein Folding Diseases Initiative

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Workshop / Seminar Fri, 31 Jan 2020 14:01:11 -0500 2020-02-06T15:00:00-05:00 2020-02-06T16:00:00-05:00 Palmer Commons Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar
BME 500: Jun Li, Ph.D. (February 6, 2020 4:00pm) https://events.umich.edu/event/70419 70419-17594471@events.umich.edu Event Begins: Thursday, February 6, 2020 4:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

In today’s research we often talk about knowledge-extraction from Big Data, and integration across different scales: molecules, cells, tissues/organs, organisms and their communities. The pursuit of multi-scale synthesis has a long history. For the microscopic world we have largely succeeded in connecting the chemical properties of molecules with the facts of atoms and their constituents and interactions. In epidemiology, many are currently applying linear mixed models to quantify the genetic contribution of disease risks in the general population. By and large, we live with the tacit belief that basic principles, once found, will be simple and elegant, and that we can build Systems Biology from the ground level. This leads to a pointillistic research culture, as when we try to explain the heredity of complex traits by summing up the individual actions of millions of DNA variants, or when we look for the neural basis of behavior by the connectivity and firing patterns of millions of neurons.
I will use this talk to share some thoughts on the emerging appreciation that, in biomedical data science, perhaps the best one can learn is not widely generalizable Mechanisms, but different laws for different scales of organization. There may not be a good chance, and perhaps no need, to "know" a system by brute force accumulation of larger and larger data at the bottom level. Acknowledging the irreducibility of highly-level phenomena in biology and medicine can help us appreciate the distinct methods, norms, and compromises in traditional disciplines, and steer the society's investment towards balanced collection of good data on all levels. By giving up the blind celebration of sample size, we give more attention to new technologies that can measure what was previously inaccessible, and to the next-generation of information science that embraces messy, context-specific models.

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Lecture / Discussion Fri, 31 Jan 2020 15:04:28 -0500 2020-02-06T16:00:00-05:00 2020-02-06T17:00:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Lecture / Discussion BME Logo
Chromatin control of cell size & embryonic development (February 10, 2020 9:30am) https://events.umich.edu/event/71736 71736-17877250@events.umich.edu Event Begins: Monday, February 10, 2020 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

We are pleased to welcome Amanda Amodeo, Ph.D. to the Kahn Auditorium of BSRB on Monday, February 10th, 2020.

Hosted by: CDB Recruitment Committee

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Lecture / Discussion Mon, 03 Feb 2020 09:39:19 -0500 2020-02-10T09:30:00-05:00 2020-02-10T10:30:00-05:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion Chromatin control of cell size & embryonic development - Amanda Amodeo, Ph.D.
Mechanobiology of Nuclear Envelope Junctions- Department of Biological Chemistry Seminar (February 11, 2020 12:00pm) https://events.umich.edu/event/72692 72692-18059647@events.umich.edu Event Begins: Tuesday, February 11, 2020 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Megan King, Associate Professor of Cell Biology at Yale School of Medicine, will be presenting a seminar in the Department of Biological Chemistry on Tuesday February 11th, 2020 at 12noon in North Lecture Hall, MS II

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Workshop / Seminar Mon, 10 Feb 2020 10:05:16 -0500 2020-02-11T12:00:00-05:00 2020-02-11T13:00:00-05:00 Medical Science Unit II Biological Chemistry Workshop / Seminar King
Bioethics Discussion: Love (February 11, 2020 7:00pm) https://events.umich.edu/event/52726 52726-12974160@events.umich.edu Event Begins: Tuesday, February 11, 2020 7:00pm
Location: Lurie Biomedical Engineering
Organized By: The Bioethics Discussion Group

A discussion on the chemistry of our biology.

Readings to consider:
1. The Neurobiology of Love
2. The Medicalization of Love
3. Self-Transcendence, the True Self, and Self-Love
4. Love yourself: The relationship of the self with itself in popular self-help texts

For more information and/or to receive a copy of the readings contact Barry Belmont at belmont@umich.edu or visit http://belmont.bme.umich.edu/bioethics-discussion-group/discussions/040-love/.

You might love the blog: https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Thu, 09 Jan 2020 09:56:11 -0500 2020-02-11T19:00:00-05:00 2020-02-11T20:30:00-05:00 Lurie Biomedical Engineering The Bioethics Discussion Group Lecture / Discussion Love
BME Ph.D Defense: Xiaotian Tan (February 12, 2020 11:00am) https://events.umich.edu/event/72235 72235-17963874@events.umich.edu Event Begins: Wednesday, February 12, 2020 11:00am
Location: Cooley Building
Organized By: Biomedical Engineering

Biosensors are devices or systems that can be used to detect, quantify, and analyze targets with biological activities and functions. As one of the largest subsets of biosensors, biomolecular sensors are specifically developed and programmed to detect, quantify and analyze biomolecules in liquid samples.

Wide-ranging applications have made immunoassays increasingly popular for biomolecular detection and quantification. Among these, enzyme-linked immunosorbent assays (ELISA) are of particular interest due to high specificity and reproducibility. To some extent, ELISA has been regarded as a “gold standard” for quantifying analytes (especially protein analytes) in both clinical diagnostics and fundamental biological research. However, traditional (96-well plate-based) ELISA still suffers from several notable drawbacks, such as long assay time (4–6 hours), lengthy procedures, and large sample/reagent consumption (∼100 μL). These inherent disadvantages still significantly limit traditional ELISA's applicability to areas such as rapid clinical diagnosis of acute diseases (e.g., viral pneumonia, acute organ rejection), and biological research that requires accurate measurements with precious or low abundance samples (e.g., tail vein serum from a mouse). Thus, a bimolecular sensing technology that has high sensitivity, short assay time, and small sample/reagent consumption is still strongly desired.

In this dissertation, we introduce the development of a multifunctional and automated optofluidic biosensing platform that can resolve the aforementioned problems. In contrast to conventional plate-based ELISA, our optofluidic ELISA platform utilizes mass-producible polystyrene microfluidic channels with a high surface-to-volume ratio as the immunoassay reactors, which greatly shortens the total assay time. We also developed a low-noise signal amplification protocol and an optical signal quantification system that was optimized for the optofluidic ELISA platform.

Our optofluidic ELISA platform provides several attractive features such as small sample/reagent consumption (<8 µL), short total assay time (30-45 min), high sensitivity (~1 pg/mL for most markers), and a broad dynamic range (3-4 orders of magnitude). Using these features, we successfully quantified mouse FSH (follicle stimulating hormone) concentration with a single drop of tail vein serum. We also successfully monitored bladder cancer progression in orthotopic xenografted mice with only <50 µL of mouse urine. More excitingly, we achieved highly-sensitive exosome quantification and multiplexed immuno-profiling with <40 ng/mL of total input protein (per assay). These remarkable milestones could not be achieved with conventional plate-based ELISA but were enabled by our unique optofluidic ELISA.

As an emerging member of the bimolecular sensor family, our optofluidic ELISA platform provides a high-performance and cost-effective tool for a plethora of applications, including endocrinal, cancer animal model, cellular biology, and even forensic science research. In the future, this technology platform can also be renovated for clinical applications such as personalized cancer diagnosis/prognosis and rapid point-of-care diagnostics for infectious diseases.

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Lecture / Discussion Thu, 30 Jan 2020 09:28:04 -0500 2020-02-12T11:00:00-05:00 2020-02-12T12:00:00-05:00 Cooley Building Biomedical Engineering Lecture / Discussion Xiaotian Tan
Establishing and Protecting the Integrity of the Nuclear Compartment- Department of Biological Chemistry Seminar (February 12, 2020 12:30pm) https://events.umich.edu/event/72693 72693-18059648@events.umich.edu Event Begins: Wednesday, February 12, 2020 12:30pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Patrick Lusk, Associate Professor of Cell Biology at Yale School of Medicine, will be presenting a seminar in the Department of Biological Chemistry on Wednesday February 12th, 2020 at 12:30pm in North Lecture Hall, MS II

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Workshop / Seminar Mon, 10 Feb 2020 10:07:59 -0500 2020-02-12T12:30:00-05:00 2020-02-12T13:30:00-05:00 Medical Science Unit II Biological Chemistry Workshop / Seminar Lusk
Department of Computational Medicine & Bioinformatics (DCMB) Weekly Seminar (February 12, 2020 4:00pm) https://events.umich.edu/event/72535 72535-18015945@events.umich.edu Event Begins: Wednesday, February 12, 2020 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract:
Normal mechanical function of the heart requires that ATP be continuously synthesized at a hydrolysis potential of roughly -60 kJ mol-1. Yet in both the aging and diseased heart the relationships between cardiac work rate and concentrations of ATP, ADP, and inorganic phosphate are altered. Important outstanding questions are: To what extent do changes in metabolite concentrations that occur in aging and heart disease affect metabolic/molecular processes in the myocardium? How are systolic and diastolic functions affected by changes in metabolite concentrations? Does metabolic energy supply represent a limiting factor in determining physiological maximal cardiac power output and exercise capacity? Does the derangement of cardiac energetics that occurs with heart failure cause exercise intolerance?

To answer these questions, we have developed a multi-physics multi-scale model of cardiac energy metabolism and cardiac mechanics that simulates the dependence of myocardial ATP demand on muscle dynamics and the dependence of muscle dynamics on cardiac energetics. Model simulations predict that the maximal rate at which ATP can be synthesized at free energies necessary to drive physiological mechanical function determine maximal heart rate, cardiac output, and cardiac power output in exercise. Furthermore, we find that reductions in cytoplasmic adenine nucleotide, creatine, and phosphate pools that occur with aging impair the myocardial capacity to synthesize ATP at physiological free energy levels, and that the resulting changes to myocardial energetic status play a causal role in contributing to reductions in maximal cardiac power output with aging. Finally, model predictions reveal that reductions in cytoplasmic metabolite pools contribute to energetic dysfunction in heart failure, which in turn contributes to causing systolic dysfunction in heart failure.

BlueJeans Livestream Link: https://primetime.bluejeans.com/a2m/live-event/rbuvycdc

3:45 p.m. - Light Refreshments served in Forum Hall Atrium
4:00 p.m. - Lecture in Forum Hall

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Lecture / Discussion Wed, 05 Feb 2020 08:41:29 -0500 2020-02-12T16:00:00-05:00 2020-02-12T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
Building the Oligodendrocyte: Mechanisms of Acentrosomal Microtubule Nucleation and mRNA Transport (February 13, 2020 9:30am) https://events.umich.edu/event/71737 71737-17877251@events.umich.edu Event Begins: Thursday, February 13, 2020 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

We are please to welcome Meng-meng Fu, Ph.D., to the Kahn Auditorium in BSRB on February 13th, 2020.

Hosted by: CDB Recruitment Committee and Center for RNA Biomedicine Recruitment Committee

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Lecture / Discussion Mon, 03 Feb 2020 09:37:18 -0500 2020-02-13T09:30:00-05:00 2020-02-13T10:30:00-05:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion Building the Oligodendrocyte: Mechanisms of Acentrosomal Microtubule Nucleation and mRNA Transport - Meng-meng Fu, Ph.D.
LSI Seminar Series: Michael Birnbaum, Ph.D., Massachusetts Institute of Technology (February 13, 2020 12:00pm) https://events.umich.edu/event/70180 70180-17540936@events.umich.edu Event Begins: Thursday, February 13, 2020 12:00pm
Location: Palmer Commons
Organized By: Life Sciences Institute (LSI)

Abstract:
The immune system relies on T cells to distinguish between normal cells and cells altered by infection or cancer. The T cells must integrate signals from their environment in deciding what cells to kill or to spare. This diversity can make determining exactly what is recognized during an immune response extremely challenging. My lab combines protein engineering, combinatorial biology, structural biology and immunology to better understand and then manipulate immune recognition. We aim to find what is recognized during the course of successful immune responses, what antigens should be targeted in treatments and how to better design cell-based immunotherapies.

About the Speaker:
Michael Birnbaum is an assistant professor of biological engineering at MIT. He received his bachelor's degree in chemical and physical biology from Harvard University and his Ph.D. from Stanford University in 2014. There, he worked under K. Christopher Garcia and studied the molecular mechanisms of T cell receptor recognition, cross-reactivity and activation. After postdoctoral work in Carla Shatz’s group at Stanford, supported by a Helen Hay Whitney Postdoctoral Fellowship, Professor Birnbaum joined MIT and the Koch Institute in 2016. During his tenure at the Koch Institute, Birnbaum has received the AACR-TESARO Career Development Award for Immuno-oncology Research, a Packard Fellowship in Science and Engineering, and a V Scholar Grant from the Jimmy V Foundation.

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Lecture / Discussion Tue, 10 Dec 2019 15:53:15 -0500 2020-02-13T12:00:00-05:00 2020-02-13T13:00:00-05:00 Palmer Commons Life Sciences Institute (LSI) Lecture / Discussion LSI Seminar Series
Revealing Principles of Subcellular RNA Localization (February 13, 2020 2:00pm) https://events.umich.edu/event/70912 70912-17735217@events.umich.edu Event Begins: Thursday, February 13, 2020 2:00pm
Location: Palmer Commons
Organized By: Department of Molecular, Cellular, and Developmental Biology

Faculty Candidate
Host: A. Wierzbicki and the Life Sciences Institute

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Workshop / Seminar Tue, 28 Jan 2020 11:22:53 -0500 2020-02-13T14:00:00-05:00 2020-02-13T15:00:00-05:00 Palmer Commons Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials and yellow microscope on blue background
Ace Your Courses: Metacognition is Key! (February 13, 2020 5:00pm) https://events.umich.edu/event/70903 70903-17735208@events.umich.edu Event Begins: Thursday, February 13, 2020 5:00pm
Location: Undergraduate Science Building
Organized By: Science Learning Center

Have you ever found yourself putting forth a great deal of effort into your courses, but not feeling like you are actually learning or are left unsatisfied with your grade? This workshop, based on the work of Dr. Saundra Yancy McGuire, will enable you to analyze your current learning strategies, understand exactly what changes you need to implement to earn an A in your courses, identify concrete strategies to use during the remainder of your semester, and become a more efficient learner.

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Workshop / Seminar Wed, 15 Jan 2020 10:19:28 -0500 2020-02-13T17:00:00-05:00 2020-02-13T18:30:00-05:00 Undergraduate Science Building Science Learning Center Workshop / Seminar Teach Yourself How to Learn by Dr. Saundra Yancy McGuire
Fighting to Build a Wall: How Cell Competition Shapes Morphogenesis in Mammalian Skin (February 17, 2020 9:30am) https://events.umich.edu/event/71738 71738-17877253@events.umich.edu Event Begins: Monday, February 17, 2020 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

We are pleased to welcome Stephanie J. Ellis, Ph.D., to the Kahn Auditorium in BSRB on Monday, February 17, 2020.

Hosted by: CDB Recruitment Committee

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Lecture / Discussion Mon, 03 Feb 2020 09:48:48 -0500 2020-02-17T09:30:00-05:00 2020-02-17T10:30:00-05:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion Fighting to Build a Wall: How Cell Competition Shapes Morphogenesis in Mammalian Skin - Stephanie J. Ellis, Ph.D.
The cell biology of lipid homeostasis: From lipid droplets to lipotoxicity (February 17, 2020 2:00pm) https://events.umich.edu/event/72190 72190-17955063@events.umich.edu Event Begins: Monday, February 17, 2020 2:00pm
Location: Palmer Commons
Organized By: Life Sciences Institute (LSI)

Speaker:

James Olzmann, Ph.D.,
Associate Professor, University of California, Berkeley

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Workshop / Seminar Tue, 11 Feb 2020 13:45:44 -0500 2020-02-17T14:00:00-05:00 2020-02-17T15:00:00-05:00 Palmer Commons Life Sciences Institute (LSI) Workshop / Seminar LSI Cancer Genetics Seminar, Feb. 17
The Role of Citrullination in Rheumatoid Arthritis- Department of Biological Chemistry Seminar (February 18, 2020 12:00pm) https://events.umich.edu/event/72694 72694-18059649@events.umich.edu Event Begins: Tuesday, February 18, 2020 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Ronak Tilvawala, Postdoctoral Associate at U-Mass Medical School, will be presenting a seminar in the Department of Biological Chemistry on Tuesday February 18th, 2020 at 12noon in North Lecture Hall, MS II

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Workshop / Seminar Mon, 10 Feb 2020 10:14:08 -0500 2020-02-18T12:00:00-05:00 2020-02-18T13:00:00-05:00 Medical Science Unit II Biological Chemistry Workshop / Seminar
Genetics Training Program / CMB Short Course (630) (February 18, 2020 3:00pm) https://events.umich.edu/event/72320 72320-17974673@events.umich.edu Event Begins: Tuesday, February 18, 2020 3:00pm
Location: Medical Science Unit II
Organized By: Department of Human Genetics

Welcome to the Exciting World of Tandem and Interspersed DNA Repeat Elements
Presented By Jayakrishnan Nandakumar, Ph.D.
Associate Professor
Department of Molecular, Cellular, and Developmental Biology University of Michigan Medical School
Tuesday, February 18, 2020
3:00 p.m.
West Lecture Hall, Med Sci II

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Lecture / Discussion Fri, 31 Jan 2020 13:25:19 -0500 2020-02-18T15:00:00-05:00 2020-02-18T16:00:00-05:00 Medical Science Unit II Department of Human Genetics Lecture / Discussion Nandakumar GTP / CMB Short Course Flyer
“Modulating kidney development: from cells to signals and transcriptional regulation” (February 18, 2020 4:00pm) https://events.umich.edu/event/71238 71238-17794026@events.umich.edu Event Begins: Tuesday, February 18, 2020 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for Cell Plasticity and Organ Design

The NIH T32 Training Program in Organogenesis is pleased to present a Special Series: "Emerging Topics in Tissue Regeneration and Engineering" featuring seminar guest Lori O'Brien, Ph.D.

Dr. O'Brien is an Assistant Professor, Department of Cell Biology and Physiology
UNC Kidney Center from the University of North Carolina.

The talk is entitled, “Modulating kidney development: from cells to signals and transcriptional regulation”.

Trainee Host: Rosa Menijvar, Ph.D. Candidate- Pasca di Magliano Lab

For additional info: 936-2499 / organogenesis@umich.edu

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Lecture / Discussion Fri, 10 Jan 2020 12:12:36 -0500 2020-02-18T16:00:00-05:00 2020-02-18T17:00:00-05:00 Taubman Biomedical Science Research Building Center for Cell Plasticity and Organ Design Lecture / Discussion Flyer
From PBB to PFAS: Research and Action to Address Michigan’s Large Scale Chemical Contaminations (February 20, 2020 9:00am) https://events.umich.edu/event/68807 68807-17153411@events.umich.edu Event Begins: Thursday, February 20, 2020 9:00am
Location: Michigan League
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

The PBB to PFAS Symposium will provide a unique venue for fostering collaboration between researchers and community members with:

• Keynote address by Dr. Linda Birnbaum (Director NIEHS, retired);

• Presentations by community residents and academic researchers working on PBB and PFAS health impacts;

• Breakout groups focused on strategies for building effective community-academic collaborations;

• Organized by UM's Center on Lifestage Environmental Exposures and Disease (M-LEEaD), Central Michigan University's Dept of History, Liberal Arts & Social Sciences, Emory University’s HERCULES Exposome Research Center;

• ADDITIONAL SPEAKERS: Michele Marcus, PhD, Emory University’s Michigan PBB Registry; Jane Keon, Pine River Superfund Citizen Task Force; Francis Spaniola, former Michigan State Representative; Tony Spaniola, JD, creator Michigan Cancer Registry; Courtney Carignan, PhD, Michigan State University; Monica Lewis-Patrick, President & CEO, River Network and We The People of Detroit

• COMMUNITY PANELISTS: Sandy Wynn-Stelt, Rockford; Theresa Landrum, Detroit; Lawrence Reynolds, Flint; Donele Wilkins, Detroit; Tim Neyer, Mt. Pleasant

• MORE SPEAKERS AND BREAKOUT SESSIONS TO BE ANNOUNCED

• Keynote address by Dr. Birnbaum will be livestreamed.

• Registration (free) is required.

• Register for the IN-PERSON Event in Ann Arbor: http://mleead.umich.edu/Event_FromPBBtoPFAS_Register.php?Attendance=InPerson
OR
• Register for the Keynote LIVESTREAM: http://mleead.umich.edu/Event_FromPBBtoPFAS_Register.php?Attendance=LiveStream

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Conference / Symposium Fri, 24 Jan 2020 16:21:01 -0500 2020-02-20T09:00:00-05:00 2020-02-20T16:00:00-05:00 Michigan League Michigan Lifestage Environmental Exposures and Disease Center Conference / Symposium PBB to PFAS symposium Feb 20 2020
BME Ph.D. Defense: Lauren L. Zimmerman (February 20, 2020 10:00am) https://events.umich.edu/event/72566 72566-18018159@events.umich.edu Event Begins: Thursday, February 20, 2020 10:00am
Location: Lurie Robert H. Engin. Ctr
Organized By: Biomedical Engineering

Department of Biomedical Engineering Final Oral Examination

Lauren L. Zimmerman

Investigating Neuromodulation as a Treatment for Female Sexual Dysfunction

Female sexual dysfunction (FSD) affects millions of women worldwide. FSD has a significant impact on quality of life and interpersonal relationships. The prevalence of at least one form of sexual dysfunction is 40-45% of adult women with 12% of women experiencing sexually related personal distress, yet there is no clear treatment option for a wide range of FSD deficits with high efficacy and low side effects.

Neuromodulation techniques using electrical stimulation of peripheral nerves have the potential to treat some forms of FSD. In clinical trials of sacral neuromodulation (SNM) and percutaneous tibial nerve stimulation (PTNS) for bladder dysfunction, women have reported that their sexual dysfunction symptoms improved as well. Even though this effect has been observed clinically, very little research has been done to examine the mechanisms or the optimal method of treatment specifically for women with FSD. This thesis aims to bridge that gap by investigating neuromodulation as a treatment for FSD through both preclinical and clinical studies.

The first aim of this thesis is to investigate a possible mechanism of the improvement to sexual functioning in response to tibial nerve stimulation by evaluating vaginal blood flow responses in rats. In 16 ketamine-anesthetized female rats, the tibial nerve was stimulated for 30 minutes while vaginal blood perfusion was recorded with laser Doppler flowmetry. A novel signal analysis and quantification metric was developed for this analysis. I found that tibial nerve stimulation could drive prolonged increases in vaginal blood perfusion, typically after 20-30 minutes of stimulation. This result suggests that clinical neuromodulation may be improving FSD symptoms by increasing genital blood flow.

One question yet to be investigated by neuromodulation studies is whether tibial nerve stimulation could be an on-demand treatment for FSD, such as Viagra is for men, or is more appropriate as a long-term treatment with improvements over time, such as PTNS for bladder dysfunction. In this thesis I address this question by evaluating the sexual motivation and receptivity of female rats both immediately after a single stimulation session as well as after long-term, repeated stimulation sessions. I found that tibial nerve stimulation led to modest increases in sexual motivation in the short term, and larger increases in sexual receptivity in the long-term.

Lastly, this thesis evaluates a pilot clinical study of transcutaneous stimulation of the dorsal genital and posterior tibial nerves in nine women with FSD. The women received stimulation once a week for 12 weeks and their sexual functioning was measured using the Female Sexual Function Index (FSFI) at baseline, after 6 weeks of stimulation, after 12 weeks of stimulation, and at 18 weeks (6 weeks after the last stimulation session). The average total FSFI score across all subjects significantly increased from baseline to each of the time points in the study. Significant FSFI increases were seen in the sub-domains of lubrication, arousal, and orgasm, each of which is related to genital arousal.

This thesis provides evidence that peripheral neuromodulation can be an effective treatment for FSD. The stimulation is likely driving increases in genital blood flow, with greater effects observed when stimulation is repeatedly applied over time. This treatment has the potential to help millions of women worldwide.

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Lecture / Discussion Wed, 05 Feb 2020 15:00:05 -0500 2020-02-20T10:00:00-05:00 2020-02-20T11:00:00-05:00 Lurie Robert H. Engin. Ctr Biomedical Engineering Lecture / Discussion BME Logo
Microfluidics Seminar: Dr. Xufeng Xue (February 20, 2020 12:00pm) https://events.umich.edu/event/73026 73026-18129602@events.umich.edu Event Begins: Thursday, February 20, 2020 12:00pm
Location: Pierpont Commons
Organized By: Biomedical Engineering

Neurulation is a key embryonic developmental process that gives rise to neural tube (NT), the precursor structure that eventually develops into the central nervous system (CNS). Understanding the molecular mechanisms and morphogenetic events underlying human neurulation is important for the prevention and treatment of neural tube defects (NTDs) and neurodevelopmental disorders. However, animal models are limited in revealing many fundamental aspects of neurulation that are unique to human CNS development. Furthermore, the technical difficulty and ethical constraint in accessing neurulation-stage human embryos have significantly limited experimental investigations of early human CNS development.
I leveraged the developmental potential and self-organizing property of human pluripotent stem cells (hPSCs) in conjunction with 2D and 3D bioengineering tools to achieve the development of spatially patterned multicellular tissues that mimic certain aspects of human neurulation, including neuroectoderm patterning and dorsal-ventral (DV) patterning of NT.
In the first section, I report a micropatterned hPSC-based neuroectoderm model, wherein pre-patterned geometrical confinement induces emergent patterning of neuroepithelial (NE) and neural plate border (NPB) cells, mimicking neuroectoderm patterning during early neurulation. My data support the hypothesis that in this hPS cell-based neuroectoderm patterning model, two tissue-scale morphogenetic signals, cell shape and cytoskeletal contractile force, instruct NE / NPB patterning via BMP-SMAD signaling. This work provides evidence of tissue mechanics-guided neuroectoderm patterning and establishes a tractable model to study signaling crosstalk involving both biophysical and biochemical determinants in neuroectoderm patterning.
In the second section, I report a human NT development model, in which NT-like tissues, termed NE cysts, are generated in a bioengineered neurogenic environment through self-organization of hPSCs. DV patterning of NE cysts is achieved using retinoic acid and/or Sonic Hedgehog, featuring sequential emergence of the ventral floor plate, p3 and pMN domains in discrete, adjacent regions and dorsal territory that is progressively restricted to the opposite dorsal pole.

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Lecture / Discussion Tue, 18 Feb 2020 08:58:46 -0500 2020-02-20T12:00:00-05:00 2020-02-20T13:00:00-05:00 Pierpont Commons Biomedical Engineering Lecture / Discussion BME Logo
Seminar: Targeting tumor-immune interplays (February 20, 2020 2:00pm) https://events.umich.edu/event/72744 72744-18070548@events.umich.edu Event Begins: Thursday, February 20, 2020 2:00pm
Location: Palmer Commons
Organized By: Life Sciences Institute (LSI)

Speaker
Peiwen Chen, Ph.D.
University of Texas, MD Anderson Cancer Center

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Workshop / Seminar Tue, 11 Feb 2020 13:50:46 -0500 2020-02-20T14:00:00-05:00 2020-02-20T15:00:00-05:00 Palmer Commons Life Sciences Institute (LSI) Workshop / Seminar Life Sciences Institute logo
BME 500: Ruixuan Gao (February 20, 2020 4:00pm) https://events.umich.edu/event/70421 70421-17594473@events.umich.edu Event Begins: Thursday, February 20, 2020 4:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Investigation of the molecular basis of a complex biological system, such as the brain, can lead to fundamental understanding of its composition and function, and to a new strategy to repair it. Such investigation, however, requires a tool that can capture biological structures and their molecular constituents across multiple orders of magnitude—from nanometers to centimeters—in length. Electron microscopy offers nanoscopic resolution but lacks molecular information to differentiate endogenous biomolecules as well as imaging speed to cover millimeter-scale specimens. Light microscopy provides molecular contrast but is limited by optical diffraction and the tradeoff between imaging speed and photobleaching.

In this talk, I will first introduce an optical imaging pipeline named expansion lattice light-sheet microscopy (ExLLSM) and its application to multiplexed, volumetric imaging of molecular constituents in cells and intact tissues. Using ExLLSM, our study has revealed molecular-specific structures of organelles, synapses, myelin sheaths, and neurites in rodent and insect brains at ∼60 by 60 by 90 nm effective resolution across dimensions that span millimeters. Next, I will present two recently developed methods that further extend the resolution and throughput of ExLLSM: (1) a non-radical hydrogel chemistry that forms a homogenous polymer network and physically separates biomolecules or fluorescent labels up to 40-fold linearly, and (2) a multi-modal optical microscopy that enables rapid, high-resolution imaging of both expanded and live tissues. Lastly, I will discuss the significance of these imaging methods in the context of microanatomy and functional omics.

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Lecture / Discussion Thu, 13 Feb 2020 10:34:18 -0500 2020-02-20T16:00:00-05:00 2020-02-20T17:00:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Lecture / Discussion BME Logo
Biologist-for-a-Day Outreach Event (February 22, 2020 1:00pm) https://events.umich.edu/event/68867 68867-17842684@events.umich.edu Event Begins: Saturday, February 22, 2020 1:00pm
Location: Biological Sciences Building
Organized By: Biology Outreach Team - BOT

Hands-on activities will demonstrate scientific concepts to families visiting campus. If you are a student and would like to be a part of this or future science outreach events, please contact the Biology Outreach Team (BOT.Contact@umich.edu).

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Community Service Thu, 16 Jan 2020 10:37:44 -0500 2020-02-22T13:00:00-05:00 2020-02-22T15:00:00-05:00 Biological Sciences Building Biology Outreach Team - BOT Community Service An activity station from a recent biology outreach event
Seminar: CRISPR tools for studying and engineering the three-dimensional genome (February 24, 2020 2:00pm) https://events.umich.edu/event/72745 72745-18070549@events.umich.edu Event Begins: Monday, February 24, 2020 2:00pm
Location: Palmer Commons
Organized By: Life Sciences Institute (LSI)

Speaker
Haifeng Wang, PH.D.
Stanford University, Department of Bioengineering

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Workshop / Seminar Tue, 11 Feb 2020 13:52:58 -0500 2020-02-24T14:00:00-05:00 2020-02-24T15:00:00-05:00 Palmer Commons Life Sciences Institute (LSI) Workshop / Seminar Life Sciences Institute logo
Defining microRNAs: How Cells Select Transcripts to Enter the microRNA pathway- Department of Biological Chemistry Seminar (February 25, 2020 12:00pm) https://events.umich.edu/event/71136 71136-17783434@events.umich.edu Event Begins: Tuesday, February 25, 2020 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Wenwen Fang, Postdoctoral Fellow at Whitehead/MIT will be presenting the Department of Biological Chemistry Seminar on Tuesday February 25th, 2020 at 12:00pm in North Lecture Hall, MS II.

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Workshop / Seminar Thu, 09 Jan 2020 06:47:39 -0500 2020-02-25T12:00:00-05:00 2020-02-25T13:00:00-05:00 Medical Science Unit II Biological Chemistry Workshop / Seminar
Defining microRNAs: How Cells Select Transcripts to Enter the microRNA pathway- Department of Biological Chemistry Seminar (February 25, 2020 12:00pm) https://events.umich.edu/event/72695 72695-18059651@events.umich.edu Event Begins: Tuesday, February 25, 2020 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Wenwen Fang, Postdoctoral Fellow at Whitehead Institute/MIT will present a seminar on Tuesday February 25th, 2020 at 12 noon in North Lecture Hall, MS II

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Workshop / Seminar Mon, 10 Feb 2020 10:18:40 -0500 2020-02-25T12:00:00-05:00 2020-02-25T13:00:00-05:00 Medical Science Unit II Biological Chemistry Workshop / Seminar
LHS Collaboratory (February 25, 2020 12:00pm) https://events.umich.edu/event/72208 72208-18035597@events.umich.edu Event Begins: Tuesday, February 25, 2020 12:00pm
Location: 1027 E. Huron Building
Organized By: Department of Learning Health Sciences

"Value Proposition of Learning Health Systems"
Erik Gordon, PhD
Clinical Assistant Professor, Ross School of Business, University of Michigan
Tuesday, February 25, 2020 – 12 pm–1:30 pm
Great Lakes Room, Palmer Commons (Lunch is included)

Professor Gordon's areas of interest are entrepreneurship and technology commercialization, venture capital, private equity, mergers and acquisitions, corporate governance, the biomedical industry (pharmaceuticals, devices, healthcare big data, and biotechnology), IoT, FinTech, and digital and mobile marketing. He also served on the faculty of University of Michigan Law School. He has served on the faculty and as Associate Dean and Director of the Graduate Division of Business & Management (Carey Business School) at Johns Hopkins University, where he taught in the business and medical schools and at the University of Florida, where he also served as director of the Center for Technology & Science Commercialization Studies and as Director of MBA Programs. He has served as an adviser or co-founder to numerous companies. He is frequently quoted in The New York Times, BusinessWeek, The Wall Street Journal, Bloomberg, Reuters and other outlets, is a regular contributor to Marketplace Morning Report (in NPR's Morning Edition), Bloomberg Radio, and appears on PBS's Nightly Business Report. His degrees are in economics and law.
Please register in advance, dlhs-umi.ch/lhs-collaboratory.
Email: LHScollaboratory-info@umich.edu

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Lecture / Discussion Fri, 07 Feb 2020 15:07:52 -0500 2020-02-25T12:00:00-05:00 2020-02-25T13:30:00-05:00 1027 E. Huron Building Department of Learning Health Sciences Lecture / Discussion LHS Collaboratory
“Embryonically Informed Tendon Regeneration Strategies” (February 25, 2020 4:00pm) https://events.umich.edu/event/71239 71239-17794030@events.umich.edu Event Begins: Tuesday, February 25, 2020 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for Cell Plasticity and Organ Design

The NIH T32 Training Program in Organogenesis is pleased to present a Special Series: "Emerging Topics in Tissue Regeneration and Engineering" featuring seminar guest Catherine K. Kuo, Ph.D.

Dr. Kuo is an Associate Professor,of Biomedical Engineering, and Center for Musculoskeletal Research at the University of Rochester.

Trainee Host: Kevin McGowan, Ph.D. Candidate-Samuelson Lab

For additional info: 936-2499 / organogenesis@umich.edu

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Lecture / Discussion Fri, 10 Jan 2020 12:17:45 -0500 2020-02-25T16:00:00-05:00 2020-02-25T17:00:00-05:00 Taubman Biomedical Science Research Building Center for Cell Plasticity and Organ Design Lecture / Discussion Kuo Flyer
BME 500: Kelly Stevens (February 27, 2020 4:00pm) https://events.umich.edu/event/70067 70067-17505693@events.umich.edu Event Begins: Thursday, February 27, 2020 4:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

The notion of building artificial human organs has moved from a far-fetched concept to the forefront of regenerative medicine research. While progress is being made, most tissues created to date are simply not large enough to support clinically meaningful functions, and their structural features remain an magnitude coarser in resolution than native tissues. Few organs better represent this challenge than the liver – the largest visceral organ in the human body, in which hepatocytes are aligned in single cell-width structures entangled with vascular and biliary networks. To address this challenge, we are working to develop a portfolio of tools that integrate 3D printing, synthetic biology, and the innate capacity of cells to self-assemble. We are applying these tools to decode the signals that drive tissue assembly during development, and using this information to build scaled artificial tissues that replicate the features of native tissues.

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Workshop / Seminar Thu, 20 Feb 2020 11:04:16 -0500 2020-02-27T16:00:00-05:00 2020-02-27T17:00:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar BME Event
Cryo-EM Studies of Molecular Motors and Their Associated Filamentous Assemblies- Department of Biological Chemistry Semianr (March 3, 2020 12:00pm) https://events.umich.edu/event/72842 72842-18085912@events.umich.edu Event Begins: Tuesday, March 3, 2020 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Charles Sindelar, Associate Professor of Molecular Biochemistry and Biophysics at Yale School of Medicine will be presenting the Department of Biological Chemistry Seminar on Tuesday March 3rd, 2020 at 12 noon in North Lecture Hall, MS II.

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Workshop / Seminar Thu, 13 Feb 2020 08:27:58 -0500 2020-03-03T12:00:00-05:00 2020-03-03T13:00:00-05:00 Medical Science Unit II Biological Chemistry Workshop / Seminar Sindelar Flyer
“Engineered kidney models derived from human induced pluripotent stem cells” (March 3, 2020 4:00pm) https://events.umich.edu/event/73334 73334-18199520@events.umich.edu Event Begins: Tuesday, March 3, 2020 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for Cell Plasticity and Organ Design

The NIH T32 Training Program in Organogenesis is pleased to present a Special Series: "Emerging Topics in Tissue Regeneration and Engineering" featuring seminar guest Samira Musah, Ph.D.

Dr. Musah is an Assistant Professor, Biomedical Engineering, Department of Medicine, Duke University.

The talk is entitled, “Engineered kidney models derived from human induced pluripotent stem cells.”

Trainee Host: Eun-Kyeoung Choi, Ph.D.-The Seo Lab

For additional info: 936-2499 / organogenesis@umich.edu

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Lecture / Discussion Wed, 26 Feb 2020 14:19:07 -0500 2020-03-03T16:00:00-05:00 2020-03-03T17:00:00-05:00 Taubman Biomedical Science Research Building Center for Cell Plasticity and Organ Design Lecture / Discussion Musah Flyer
How to make a stem cell: Gene regulatory principles learned from vascular fate transitions (March 5, 2020 3:00pm) https://events.umich.edu/event/72083 72083-17937811@events.umich.edu Event Begins: Thursday, March 5, 2020 3:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

We are pleased to welcome Dionna M. Kasper, Ph.D., Post-Doctoral Fellow, Yale University School of Medicine to the Kahn Auditorium in BSRB on Thursday, March 5, 2020.

Hosted by: CDB Recruitment Committee

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Lecture / Discussion Mon, 03 Feb 2020 09:49:59 -0500 2020-03-05T15:00:00-05:00 2020-03-05T16:00:00-05:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion How to make a stem cell: Gene regulatory principles learned from vascular fate transitions
BME 500: Ruobo Zhou (March 5, 2020 4:00pm) https://events.umich.edu/event/73399 73399-18214945@events.umich.edu Event Begins: Thursday, March 5, 2020 4:00pm
Location: Industrial and Operations Engineering Building
Organized By: Biomedical Engineering

Biomolecular interactions are at the root of all biological processes and define the molecular mechanisms of how these processes are accomplished in both physiological and pathological conditions. Recent advances in single molecule detection and super-resolution fluorescence microcopy have uncovered previously unknown properties of biomolecular interactions, including multivalency, transiency, and heterogeneity, and revealed the organizational principles governing the compartmentalization of functional biomolecular interactions in cells and how such compartmentalization and organizations become dysregulated in diseases. In this talk, I will first discuss my postdoctoral work, where I used mass-spectrometry-based analysis and super-resolution imaging to dissect the protein-protein interactions at the plasma membrane of neurons, and discovered that a newly identified membrane-associated periodic skeleton (MPS) structure can function as a signaling platform that coordinates the interactions of signaling proteins at the plasma membrane of neurons. In response to extracellular stimuli, G-protein coupled receptors, cell-adhesion molecules, receptor tyrosine kinases can be recruited to the MPS to form signaling complexes at the plasma membrane, and such recruitment is required for downstream intracellular signaling. This work not only reveals an important, previously unknown function of the newly discovered MPS structure, but also provides novel mechanistic insights into signal transduction in neurons. I will then discuss my graduate work, where I developed a hybrid single molecule technique combining single molecule FRET and optical tweezers, and applied this technique to probe the sub-molecular dynamics of protein-DNA interactions in various biological systems involved in DNA replication, repair and recombination.

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Lecture / Discussion Fri, 28 Feb 2020 11:07:38 -0500 2020-03-05T16:00:00-05:00 2020-03-05T17:00:00-05:00 Industrial and Operations Engineering Building Biomedical Engineering Lecture / Discussion BME Logo
Forum on "Climate Change and Health: Readiness and Resilience" (March 10, 2020 12:00pm) https://events.umich.edu/event/72763 72763-18070598@events.umich.edu Event Begins: Tuesday, March 10, 2020 12:00pm
Location: Towsley Center for Cont. Med Ed
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

*Please register by going to http://mleead.umich.edu/Event_Climate_Change_and_Health_2020.php*

Our climate is our planet’s life support system. Climate change influences human health and disease in numerous ways, including impacts from increased extreme weather events, wildfire, decreased air quality, and illnesses transmitted by food, water, and disease carriers such as mosquitoes and ticks. As described in the Lancet Countdown report, some existing health threats will intensify and new health threats will emerge. Not everyone is equally at risk, and children are especially at risk. Preventive and adaptive actions are needed.

The keynote speaker is an emergency medicine physician who co-authored the U.S. portion of the Lancet Countdown report and Health and Care Delivery in the New England Journal of Medicine. A panel of experts will present solutions from a variety of other universities who are reducing their carbon footprint in response to the urgent public health need.

Welcome: Joseph C. Kolars, MD, Senior Associate Dean for Education and Global Initiatives, UM Medical School

Keynote: "Climate Action: Children’s Health Drives Need for Urgent Action" Renee N. Salas, MD, MPH, MS, Clinical Instructor of Emergency Medicine, Harvard Medical School and emergency medicine physician, Massachusetts General Hospital

Schedule
11:00-11:45 am | Registration outside of Dow Auditorium, Towsley Center for Continuing Medical Education, Michigan Medicine
11:00-11:45 am | Lunch in Towsley Center Dining Room for registered guests
12:00-1:30 pm | Program in Dow Auditorium, Towsley Center (also will be live streamed)
1:30-2:00 pm | Reception in Towsley Center Dining Room

*Please register by going to http://mleead.umich.edu/Event_Climate_Change_and_Health_2020.php*

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Conference / Symposium Fri, 21 Feb 2020 13:52:24 -0500 2020-03-10T12:00:00-04:00 2020-03-10T13:30:00-04:00 Towsley Center for Cont. Med Ed Michigan Lifestage Environmental Exposures and Disease Center Conference / Symposium Climate Change and Health: Readiness and Resilience
Development of genetically engineered mouse models of brainstem glioma: therapeutic efficacy of an immune mediated gene therapy strategy (March 10, 2020 2:00pm) https://events.umich.edu/event/72701 72701-18061828@events.umich.edu Event Begins: Tuesday, March 10, 2020 2:00pm
Location: Medical Science Unit II
Organized By: Cell & Developmental Biology

Dissertation Seminar:
We are pleased to welcome Flor Mendez, Ph.D. Student at University of Michigan to 2710 Furstenberg, Med Sci II on March 10th, 2020 at 2:00 pm to present her dissertation seminar.

Hosted by the Dissertation Committee:
Professor Maria Castro, Mentor
Professor Roman Giger, Chair
Associate Professor Maria Figueroa
Associate Professor Marina Pasca Di Magliano

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Lecture / Discussion Mon, 10 Feb 2020 15:06:45 -0500 2020-03-10T14:00:00-04:00 2020-03-10T15:00:00-04:00 Medical Science Unit II Cell & Developmental Biology Lecture / Discussion Development of genetically engineered mouse models of brainstem glioma: therapeutic efficacy of an immune mediated gene therapy strategy - Flor Mendez
MCDB Dissertation Defense: "Molecular Mechanisms of Golgi Structure Alterations during Stress” (March 10, 2020 2:00pm) https://events.umich.edu/event/72769 72769-18070599@events.umich.edu Event Begins: Tuesday, March 10, 2020 2:00pm
Location: Rackham Graduate School (Horace H.)
Organized By: Department of Molecular, Cellular, and Developmental Biology

Mentor: Y. Wang

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Workshop / Seminar Mon, 09 Mar 2020 15:49:26 -0400 2020-03-10T14:00:00-04:00 2020-03-10T16:00:00-04:00 Rackham Graduate School (Horace H.) Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials & microscope drawing in yellow on a blue square
“Epigenetic pathways as targets in human disease” (March 10, 2020 4:00pm) https://events.umich.edu/event/73335 73335-18199521@events.umich.edu Event Begins: Tuesday, March 10, 2020 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for Cell Plasticity and Organ Design

Center for Organogenesis along with the Human Genetics Depatment is pleased to present a seminar talk by Dr. Shelley Berger.

Dr. Berger is Daniel S. Och Professor of Cell & Developmental Biology at University of Pennsylvania School of Medicine.

The talk is entitled, “Epigenetic pathways as targets in human disease.”

Faculty Host: Sue Hammoud, Ph.D.

For additional info: 936-2499 / organogenesis@umich.edu

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Lecture / Discussion Wed, 26 Feb 2020 14:29:36 -0500 2020-03-10T16:00:00-04:00 2020-03-10T17:00:00-04:00 Taubman Biomedical Science Research Building Center for Cell Plasticity and Organ Design Lecture / Discussion Berger Flyer
DCMB Weekly Seminar (March 11, 2020 4:00pm) https://events.umich.edu/event/73002 73002-18123077@events.umich.edu Event Begins: Wednesday, March 11, 2020 4:00pm
Location:
Organized By: DCMB Seminar Series

Abstract:

In this talk, some major challenges are reviewed of using Artificial Intelligence (AI) to address the needs of medicine and healthcare. These challenges include technical issues such as data-related and/or algorithmic challenges that the use of AI for medicine would present. The speaker then presents some potential solutions in form of novel algorithmic approaches that may at least partially address some of these challenges.

BlueJeans livestream: https://primetime.bluejeans.com/a2m/live-event/rbuvycdc

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Lecture / Discussion Wed, 11 Mar 2020 08:49:28 -0400 2020-03-11T16:00:00-04:00 2020-03-11T17:00:00-04:00 DCMB Seminar Series Lecture / Discussion
BME 500: Rebecca Wachs (March 12, 2020 4:00pm) https://events.umich.edu/event/70068 70068-17505695@events.umich.edu Event Begins: Thursday, March 12, 2020 4:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

The majority of the population will experience low back pain in their lifetime. Degeneration of the intervertebral disc is highly correlated with low back pain, however, not all disc degeneration is painful. One of the most common forms of low back pain is disc-associated low back pain in which pain originates from intervertebral disc. In disc-associated low back pain, nerve fibers penetrate the previously aneural disc, where they are then thought to be stimulated by the harsh catabolic environment. Repetitive stimulation of these nerve fibers can cause sensitization and chronic pain. The overarching goal of our work is to engineer biomaterials that target these two key areas of disc-associated low back pain: nerve growth and stimulation. Current clinical treatments for chronic low back pain have limited efficacy or are highly invasive. The majority of research to date focuses on regenerating a young healthy disc. We believe our approach to target nerve growth and stimulation independent of disc regeneration has the potential shift the paradigm in the treatment of low back pain.

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Workshop / Seminar Tue, 10 Mar 2020 11:43:59 -0400 2020-03-12T16:00:00-04:00 2020-03-12T17:00:00-04:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar BME Event
Annual Symposium in Biophysics (March 13, 2020 8:00am) https://events.umich.edu/event/69839 69839-17472589@events.umich.edu Event Begins: Friday, March 13, 2020 8:00am
Location: Michigan Union
Organized By: LSA Biophysics

TBD

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Conference / Symposium Mon, 02 Dec 2019 08:43:25 -0500 2020-03-13T08:00:00-04:00 2020-03-13T17:00:00-04:00 Michigan Union LSA Biophysics Conference / Symposium Michigan Union
Michigan Tech Expo (March 13, 2020 9:00am) https://events.umich.edu/event/72277 72277-17966107@events.umich.edu Event Begins: Friday, March 13, 2020 9:00am
Location: Ross School of Business
Organized By: Atlas Consulting Group

Michigan Tech Expo is a one-day conference with a groundbreaking speaker series of leaders and social innovators speaking about the future of their industries as well as an immersive tech environment with new and exciting technologies offering a firsthand glimpse into the future

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Conference / Symposium Fri, 31 Jan 2020 15:02:54 -0500 2020-03-13T09:00:00-04:00 2020-03-13T17:00:00-04:00 Ross School of Business Atlas Consulting Group Conference / Symposium Michigan Tech Expo Logo
CANCELED: Mechanisms Linking Cell Mechanics and Metabolism (March 13, 2020 12:00pm) https://events.umich.edu/event/72757 72757-18070590@events.umich.edu Event Begins: Friday, March 13, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Ann Miller

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Workshop / Seminar Tue, 10 Mar 2020 11:32:19 -0400 2020-03-13T12:00:00-04:00 2020-03-13T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar microscope drawing, MCDB initials in yellow on blue background
POSTPONED until fall 2020: EEB Early Career Scientists Symposium | Natural History Collections: Drivers of Innovation (March 14, 2020 8:00am) https://events.umich.edu/event/70505 70505-17602796@events.umich.edu Event Begins: Saturday, March 14, 2020 8:00am
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Watch for updates later this year.

The Department of Ecology and Evolutionary Biology at the University of Michigan is pleased to present Natural History Collections: Drivers of Innovation, an exciting symposium about innovative and unconventional uses of biological collections across scientific disciplines. The symposium events will take place from the 13-15 March 2020, on the campus of the University of Michigan in Ann Arbor.

When biologists think of natural history collections, most tend to think of taxonomy and systematics, yet many are unaware of the uses of biological collections beyond those traditional fields. These studies span the breadth of the tree of life and address broad subjects that span comparative genomics to bioengineering and climate change to historical pathogen dynamics, among many, many more. As stewards of one of the largest university-based biological collections in the world, we are in an extraordinary position to leverage our holdings of biological material from the last century or more. We envision this symposium as a way to showcase the often-unrealized opportunities and non-traditional avenues of research that our collections make possible to the entire scientific community, and emphasize some of the interdisciplinary ways in which our collections are being or could be used. We hope to foster a broader understanding and expanded use of an incomparable resource that the University of Michigan has cultivated for the past two hundred years.

The symposium will feature both established and novel uses of natural history collections across a wide range of taxonomic groups, systems, and time. Our goal is to create a program with contributions from all corners of ecology and evolutionary biology. The program will include two keynote talks by senior speakers and additional talks by early-career speakers.

Thank you!

ECSS 2020 Committee
Jenna Crowe-Riddell
Sonal Gupta
Hernán Lopez-Fernandez, chair
Benjamin Nicholas
Teresa Pegan
Brad Ruhfel
Cody Thompson
Taylor West

Administrative Support
Event coordination: Linda Garcia & Molly Hunter
Event promotion: Gail Kuhnlein
Graphic design/art: John Megahan
Photography: Dale Austin

Image credits:
Painted meadow grasshopper, western rattlesnake, burrowing owl: Eric LoPresti. Moon snail, plant, rabbit skull: John Megahan. Mushrooms: Tim James. Background cabinet: Linda Garcia. Design: John Megahan.

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Conference / Symposium Tue, 10 Mar 2020 16:24:06 -0400 2020-03-14T08:00:00-04:00 2020-03-14T17:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Conference / Symposium Background of collections drawers with boxes on top containing the following: moon snail, painted meadow grasshopper, plant, mushrooms, western rattlesnake, burrowing owl, rabbit skull
CANCELED: Organization of cellular fat store . . . (March 17, 2020 12:00pm) https://events.umich.edu/event/72758 72758-18070591@events.umich.edu Event Begins: Tuesday, March 17, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

This seminar has been cancelled.

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Workshop / Seminar Tue, 10 Mar 2020 10:50:42 -0400 2020-03-17T12:00:00-04:00 2020-03-17T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials and yellow microscope drawing on a blue square
(CANCELLED) “Ciliary signaling: not just for Hedgehogs anymore!” (March 17, 2020 4:00pm) https://events.umich.edu/event/73336 73336-18328746@events.umich.edu Event Begins: Tuesday, March 17, 2020 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for Cell Plasticity and Organ Design

Center for Organogenesis along with the Human Genetics Depatment is pleased to present a seminar talk by Dr. Jeremy Reiter.

Dr. Reiter, is Professor & Chair, Department of Biochemistry and Biophysics, from University of California, San Francisco.

The talk is entitled, “Ciliary signaling: not just for Hedgehogs anymore!”

Faculty Host: Sunny Wong, Ph.D.

For additional info: 936-2499 / organogenesis@umich.edu

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Lecture / Discussion Thu, 12 Mar 2020 10:57:28 -0400 2020-03-17T16:00:00-04:00 2020-03-17T17:00:00-04:00 Taubman Biomedical Science Research Building Center for Cell Plasticity and Organ Design Lecture / Discussion Reiter Flyer
CANCELED - Health Professions Education Day 2020 (March 17, 2020 8:00pm) https://events.umich.edu/event/62030 62030-18377655@events.umich.edu Event Begins: Tuesday, March 17, 2020 8:00pm
Location:
Organized By: Department of Learning Health Sciences

This event aims to bring together educational scholars, practitioners,
researchers, and students to share best practices and explore
opportunities for collaboration and innovation around health professions
education and interprofessional education, in particular.
The day’s highlights will include poster presentations, networking, and
exchanging of best practices in implementation of interprofessional education.
We also aim to continue the growth of collaborations across the health science
schools and the broader University of Michigan community and campuses.

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Conference / Symposium Tue, 17 Mar 2020 20:13:50 -0400 2020-03-17T20:00:00-04:00 2020-03-17T21:00:00-04:00 Department of Learning Health Sciences Conference / Symposium HPE Day 2019
CANCELED - Health Professions Education Day 2020 (March 17, 2020 8:00pm) https://events.umich.edu/event/62030 62030-18377656@events.umich.edu Event Begins: Tuesday, March 17, 2020 8:00pm
Location:
Organized By: Department of Learning Health Sciences

This event aims to bring together educational scholars, practitioners,
researchers, and students to share best practices and explore
opportunities for collaboration and innovation around health professions
education and interprofessional education, in particular.
The day’s highlights will include poster presentations, networking, and
exchanging of best practices in implementation of interprofessional education.
We also aim to continue the growth of collaborations across the health science
schools and the broader University of Michigan community and campuses.

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Conference / Symposium Tue, 17 Mar 2020 20:13:50 -0400 2020-03-17T20:00:00-04:00 2020-03-17T21:00:00-04:00 Department of Learning Health Sciences Conference / Symposium HPE Day 2019
CANCELED - Health Professions Education Day 2020 (March 17, 2020 8:00pm) https://events.umich.edu/event/62030 62030-18377657@events.umich.edu Event Begins: Tuesday, March 17, 2020 8:00pm
Location:
Organized By: Department of Learning Health Sciences

This event aims to bring together educational scholars, practitioners,
researchers, and students to share best practices and explore
opportunities for collaboration and innovation around health professions
education and interprofessional education, in particular.
The day’s highlights will include poster presentations, networking, and
exchanging of best practices in implementation of interprofessional education.
We also aim to continue the growth of collaborations across the health science
schools and the broader University of Michigan community and campuses.

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Conference / Symposium Tue, 17 Mar 2020 20:13:50 -0400 2020-03-17T20:00:00-04:00 2020-03-17T21:00:00-04:00 Department of Learning Health Sciences Conference / Symposium HPE Day 2019
CANCELED! From Laboratory to Population: Molecular Epidemiology in Action (March 20, 2020 9:00am) https://events.umich.edu/event/71052 71052-17768679@events.umich.edu Event Begins: Friday, March 20, 2020 9:00am
Location: Rackham Graduate School (Horace H.)
Organized By: MAC-EPID

"Antibiotic use during pregnancy: Too much of a good thing?"
Lixin Zhang, PhD (Assistant Professor, Epidemiology & Biostatistics and Microbiology & Molecular Genetics, Michigan State University)

"Group B streptococcal epidemiology and pathogenesis: A tribute to Carl Marrs’ mentorship"
Shannon Manning, PhD (MSU Foundation Associate Professor of Microbiology and Molecular Genetics, Michigan State University)

"Integrating Operational Research to Combat Epidemics: Investigating Ebola Infection among Health Workers in Kenema, Sierra Leone, 2014"
Mikiko Senga, PhD (Disease Outbreak Team Lead, Health Emergencies Programme, World Health Organization, Yemen)

Epidemiology Alumni Reception directly following talks.

Please register for this free symposium since lunch will be provided. Thank you!

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Conference / Symposium Wed, 11 Mar 2020 16:26:18 -0400 2020-03-20T09:00:00-04:00 2020-03-20T16:00:00-04:00 Rackham Graduate School (Horace H.) MAC-EPID Conference / Symposium CANCELED Flyer
Canceled: Shaping the cell from the outside in (March 20, 2020 12:00pm) https://events.umich.edu/event/72760 72760-18070592@events.umich.edu Event Begins: Friday, March 20, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Anthony Vecchiarelli

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Workshop / Seminar Tue, 10 Mar 2020 14:55:11 -0400 2020-03-20T12:00:00-04:00 2020-03-20T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials & microscope drawing in yellow on a blue square
LHS Collaboratory Webinar "Mobilizing Computable Biomedical Knowledge at Michigan Medicine" (March 24, 2020 12:00pm) https://events.umich.edu/event/72652 72652-18035599@events.umich.edu Event Begins: Tuesday, March 24, 2020 12:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Presentation 1:
"Electronic Health Record (EHR)-Integration for Learning Health Systems"

Michael Lanham, MD
Associate Chief Medical Information Officer
Clinical Assistant Professor of Learning Health Sciences
Assistant Professor of Obstetrics & Gynecology; Fertility and Reproductive Health
University of Michigan

Presentation 2:
“Machine Learning Infrastructure in a Learning Health System”

Karandeep Singh, MD, MMSc
Assistant Professor of Learning Health Sciences
Assistant Professor of Medicine
University of Michigan


Please register in advance, *dlhs-umi.ch/lhs-collaboratory. *
Email: *LHScollaboratory-info@umich.edu*

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Lecture / Discussion Wed, 18 Mar 2020 10:04:19 -0400 2020-03-24T12:00:00-04:00 2020-03-24T13:30:00-04:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion LHS Collaboratory
(CANCELLED)“Exploring mechanisms of cell number compensation during brain development and cancer” (March 24, 2020 4:00pm) https://events.umich.edu/event/73360 73360-18328747@events.umich.edu Event Begins: Tuesday, March 24, 2020 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for Cell Plasticity and Organ Design

Center for Organogenesis along with the Human Genetics Depatment is pleased to present a seminar talk by Dr. Alexandra Joyner.

Dr. Joyner is Courtney Steel Chair in Pediatric Cancer Research Developmental Biology Program at Sloan Kettering Institute.

The talk is entitled, “Exploring mechanisms of cell number compensation during brain development and cancer.”

Faculty Host: Ben Allen, Ph.D.

For additional info: 936-2499 / organogenesis@umich.edu

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Lecture / Discussion Mon, 09 Mar 2020 10:01:09 -0400 2020-03-24T16:00:00-04:00 2020-03-24T17:00:00-04:00 Taubman Biomedical Science Research Building Center for Cell Plasticity and Organ Design Lecture / Discussion Joyner Seminar Flyer
Zhen Xu, PhD: Histotripsy Webinar (March 25, 2020 10:00am) https://events.umich.edu/event/73931 73931-18426654@events.umich.edu Event Begins: Wednesday, March 25, 2020 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This will be held online. Click the link below to register.

https://fusfoundation.zoom.us/webinar/register/WN_Hj_R2DMOT8SlOAp0WRLV3A

Oftentimes when we think of focused ultrasound, we imagine using it to heat and kill tissue. Unlike thermal ablation, histotripsy uses focused ultrasound to mechanically disrupt the target tissue without heating. Histotripsy turns the tissue into liquid-appearing acellular debris – which is absorbed by the body over one to two months – resulting in effective tissue removal.

Histotripsy has been shown to stimulate a powerful immune response in cancer treatment studies. In the treatment of neurological diseases, transcranial histotripsy can produce well-confined focal treatment in a wide range of locations and volumes in the brain, offering the potential to increase the treatment envelope while decreasing treatment time.

Please register to join us at 10:00 AM Eastern on Wednesday, March 25, when Zhen Xu, PhD, will discuss the basic mechanism, instrumentation, bioeffects, and applications of histotripsy. She will also cover the latest preclinical and clinical trial results of developing histotripsy for the treatment of cancer and neurological diseases.

About the Speaker

Zhen Xu, PhD, is a tenured Associate Professor in the Department of Biomedical Engineering at the University of Michigan and a primary inventor and pioneer in histotripsy.

She has received many notable awards, including:
IEEE Ultrasonics, Ferroelectrics, and Frequency Control Society Outstanding Paper Award (2006)
American Heart Association Outstanding Research in Pediatric Cardiology (2010)
National Institutes of Health (NIH) New Investigator Award at the First National Institute of Biomedical Imaging and Bioengineering (NIBIB) Edward C. Nagy New Investigator Symposium (2011)
The Federic Lizzi Early Career Award from The International Society of Therapeutic Ultrasound (ISTU) (2015)
Fellow of the American Institute of Medical and Biological Engineering (2019)
Dr. Xu is currently an associate editor for three notable journals: IEEE Transactions on Ultrasound, Ferroelectrics, and Frequency Control (UFFC); Frontiers in Bioengineering; and BME Frontiers. She is an elected board member of ISTU, a charter member of the US NIH study section, and a principal investigator of grants funded by the Focused Ultrasound Foundation, NIH, American Cancer Association, Office of Naval Research, The Hartwell Foundation, and The Coulter Foundation.

She received her PhD from the University of Michigan in 2005.

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Livestream / Virtual Mon, 23 Mar 2020 14:42:17 -0400 2020-03-25T10:00:00-04:00 2020-03-25T11:00:00-04:00 Off Campus Location Biomedical Engineering Livestream / Virtual BME Logo
Ph.D. Defense: Tyler Gerhardson (March 26, 2020 10:00am) https://events.umich.edu/event/73025 73025-18129601@events.umich.edu Event Begins: Thursday, March 26, 2020 10:00am
Location: Lurie Robert H. Engin. Ctr
Organized By: Biomedical Engineering

NOTICE: Will be held via BlueJeans.

Link: https://umich.bluejeans.com/924142541

Brain pathologies including stroke and cancer are a major cause of death and disability. Intracerebral hemorrhage (ICH) accounts for roughly 12% of all strokes in the US with approximately 200,000 new cases per year. ICH is characterized by the rupture of vessels resulting in bleeding and clotting inside the brain. The presence of the clot causes immediate damage to surrounding brain tissue via mass effect with delayed toxic effects developing in the days following the hemorrhage. This leads ICH patients to high mortality with a 40% chance of death within 30 days of diagnosis and motivates the need to quickly evacuate the clot from the brain. Craniotomy surgery and other minimally invasive methods using thrombolytic drugs are common procedures to remove the clot but are limited by factors such as morbidity and high susceptibility to rebleeding, which ultimately result in poor clinical outcomes.

Histotripsy is a non-thermal ultrasound ablation technique that uses short duration, high amplitude rarefactional pulses (>26 MPa) delivered via an extracorporeal transducer to generate targeted cavitation using the intrinsic gas nuclei existing in the target tissue. The rapid and energetic bubble expansion and collapse of cavitation create high stress and strain in tissue at the focus that fractionate it into an acellular homogenate. This dissertation presents the role of histotripsy as a novel ultrasound technology with potential to address the need for an effective transcranial therapy for ICH and other brain pathologies.

The first part of this work investigates the effects of ultrasound frequency and focal spacing on transcranial clot liquefaction using histotripsy. Histotripsy pulses were delivered using two 256-element hemispherical transducers of different frequency (250 and 500 kHz) with 30-cm aperture diameters. Liquefied clot was drained via catheter and syringe in the range of 6-59 mL in 0.9-42.4 min. The fastest rate was 16.6 mL/min. The best parameter combination was λ spacing at 500 kHz, which produced large liquefaction through 3 skullcaps (~30 mL) with fast rates (~2 mL/min). The temperature-rise through the 3 skullcaps remained below 4°C.

The second part addresses initial safety concerns for histotripsy ICH treatment through investigation in a porcine ICH model. 1.75-mL clots were formed in the frontal lobe of the brain. The centers of the clots were liquefied with histotripsy 48 h after formation, and the content was either evacuated or left within the brain. A control group was left untreated. Histotripsy was able to liquefy the core of clots without direct damage to the perihematomal brain tissue. An average volume of 0.9 ± 0.5 mL (~50%) was drained after histotripsy treatment. All groups showed mild ischemia and gliosis in the perihematomal region; however, there were no deaths or signs of neurological dysfunction in any groups.

The third part presents the development of a novel catheter hydrophone method for transcranial phase aberration correction and drainage of the clot liquefied with histotripsy. A prototype hydrophone was fabricated to fit within a ventriculostomy catheter. Improvements in focal pressure of up to 60% were achieved at the geometric focus and 27%-62% across a range of electronic steering locations. The sagittal and axial -6-dB beam widths decreased from 4.6 to 2.2 mm in the sagittal direction and 8 to 4.4 mm in the axial direction, compared to 1.5 and 3 mm in the absence of aberration. The cores of clots liquefied with histotripsy were readily drained via the catheter.

The fourth part focuses on the development of a preclinical system for translation to human cadaver ICH models. A 360-element, 700 kHz hemispherical array with a 30 cm aperture was designed and integrated with an optical tracker surgical navigation system. Calibrated simulations of the transducer suggest a therapeutic range between 48 – 105 mL through the human skull with the ability to apply therapy pulses at pulse-repetition-frequencies up to 200 Hz. The navigation system allows real-time targeting and placement of the catheter hydrophone via a pre-operative CT or MRI.

The fifth and final part of this work extends transcranial histotripsy therapy beyond ICH to the treatment of glioblastoma. This section presents results from an initial investigation into cancer immunomodulation using histotripsy in a mouse glioblastoma model. The results suggest histotripsy has some immunomodulatory capacity as evidenced by a 2-fold reduction in myeloid derived suppressor cells and large increases in interferon-γ concentrations (3500 pg/mL) within the brain tumors of mice treated with histotripsy.

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Lecture / Discussion Mon, 16 Mar 2020 13:26:52 -0400 2020-03-26T10:00:00-04:00 2020-03-26T11:00:00-04:00 Lurie Robert H. Engin. Ctr Biomedical Engineering Lecture / Discussion BME Logo
CANCELED Coatopathies: Genetic Disorders of Protein Coat (March 27, 2020 12:00pm) https://events.umich.edu/event/72762 72762-18070593@events.umich.edu Event Begins: Friday, March 27, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Ming Li

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Workshop / Seminar Tue, 10 Mar 2020 10:49:33 -0400 2020-03-27T12:00:00-04:00 2020-03-27T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials & microscope drawing in yellow on a blue square
CANCELED--Genomes gone wild: Experimental evolution meets synthetic biology (April 3, 2020 12:00pm) https://events.umich.edu/event/72765 72765-18070595@events.umich.edu Event Begins: Friday, April 3, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Andrzej Wierzbicki

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Workshop / Seminar Thu, 12 Mar 2020 08:59:45 -0400 2020-04-03T12:00:00-04:00 2020-04-03T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials microscope drawing on blue square
Defense: The Ins and Outs of Melanopsin Signaling (April 7, 2020 2:00pm) https://events.umich.edu/event/74029 74029-18491691@events.umich.edu Event Begins: Tuesday, April 7, 2020 2:00pm
Location:
Organized By: Department of Molecular, Cellular, and Developmental Biology

Mentor: Kwoon Wong

Abstract: Intrinsically photosensitive retinal ganglion cells (ipRGCs) are responsible for non-image-forming functions such as circadian photoentrainment, pupillary light reflex and the suppression of melatonin. Additionally, their axons innervate two main image-forming visual nuclei: the superior colliculus (SC) and the lateral geniculate nucleus (LGN). Furthermore, electrophysiology data discovered that ipRGCs signal to dopaminergic amacrine cells via AMPA/Kainate glutamate receptors and to displaced amacrine cells (ACs) located in the ganglion cell layer of the retina through gap junctions. Retinal ganglion cells had never been found to signal intraretinally prior to this finding.

Several labs have been exploring how ipRGCs mediate or modulate image-forming vision through their central projections and signaling to dopaminergic ACs. However, little is known about the functional roles of gap-junction signaling from ipRGCs to displaced ACs and how ipRGCs work in conjunction with rod and cone photoreceptors to mediate image-forming visual responses. Neurobiotin tracer injections, immunostaining, and optokinetic visual behavior techniques were used in this thesis to fill in this knowledge gap. Four specific aims were accomplished: 1) understand how ipRGC-coupled ACs are distributed across the retina and identify ipRGC-coupled ACs, 2) test the hypothesis that connexin36 (Cx36) couples ipRGCs to displaced ACs, 3) examine the effect of glutamatergic input on ipRGC-AC coupling, and 4) assess the effect of rods, cones and melanopsin on image-forming behavior.

We found that all six ipRGC types are electrically coupled to amacrine cells, primarily via Cx36 and a few ipRGC-coupled amacrine cells are bNOS, nNOS, NPY or 5-HT immunopositive. ipRGC-AC coupling is enhanced in the presence of NMDA receptor expression in ipRGCs. We found the distribution of ipRGC-coupled amacrine cells is region specific, and rods, cones and melanopsin contribute to image-forming vision differently. Because ipRGCs remain light-sensitive in many blind patients suffering from rod and cone degeneration, a better understanding of the signaling ipRGCs could lead to novel strategies to restore sight in such patients.

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Other Tue, 07 Apr 2020 10:39:55 -0400 2020-04-07T14:00:00-04:00 2020-04-07T16:00:00-04:00 Department of Molecular, Cellular, and Developmental Biology Other yellow microscope on blue square
Master's Thesis Defense: Mingyang Wang (April 10, 2020 10:30am) https://events.umich.edu/event/73990 73990-18460430@events.umich.edu Event Begins: Friday, April 10, 2020 10:30am
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be held via Blue Jeans. It will be linked before.

BlueJeans: https://bluejeans.com/315155702

Objectives
We have developed a novel anti-vascular technique, termed photo-mediated ultrasound therapy (PUT), which utilizes nanosecond duration laser pulses synchronized with ultrasound bursts to remove microvasculature through cavitation. The objective of the current study is to explore the potential of PUT in removing cutaneous microvessels.

Methods
The auricular blood vessels of two New Zealand white rabbits were treated by PUT with a peak negative ultrasound pressure of 0.45 MPa at 0.5 MHz, and a laser fluence of 0.056 J/cm2 at 1064 nm for 10 minutes. Blood perfusion in the treated area was measured by a commercial laser speckle imaging (LSI) system before and immediately after treatment, as well as at one hour, three days, two weeks, and four weeks post treatment. Perfusion rates of 38 individual vessels from 4 rabbit ears were tracked during this time period for longitudinal assessment.

Results
The measured perfusion rates of the vessels in the treated areas, as quantified by the relative change in perfusion rate (RCPR), showed a statistically significant decrease for all time points post treatment (p<0.001). The mean decrease in perfusion is 50.79% immediately after treatment and is 32.14% at four weeks post treatment. Immediately after treatment, the perfusion rate decreased rapidly. Following this, there was a partial recovery in perfusion rate up to 3 days post treatment, then followed by a plateau in the perfusion from 3 days to 4 weeks.

Conclusions
The study demonstrated that a single PUT treatment could significantly reduce blood perfusion by 32.14% in the skin for up to 4 weeks. With unique advantages such as low laser fluence as compared with photothermolysis and agent-free treatment as compared with PDT, PUT holds potential to be developed into a new tool for the treatment of microvessels in the skin.

Keywords: laser; ultrasound; anti-vascular treatment; skin microvessels; photo-mediated ultrasound therapy

Chair: Dr. Xueding Wang

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Lecture / Discussion Fri, 27 Mar 2020 13:53:59 -0400 2020-04-10T10:30:00-04:00 2020-04-10T11:30:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
CANCELED: How do Fatty Acids Induce Mitochondrial H+ leak and Thermogenesis? (April 10, 2020 12:00pm) https://events.umich.edu/event/72766 72766-18070596@events.umich.edu Event Begins: Friday, April 10, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Haoxing Xu

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Workshop / Seminar Tue, 10 Mar 2020 10:51:44 -0400 2020-04-10T12:00:00-04:00 2020-04-10T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials & microscope drawing in yellow on a blue square
CANCELED - Health Professions Education Day 2020 (April 14, 2020 8:00am) https://events.umich.edu/event/62030 62030-15276109@events.umich.edu Event Begins: Tuesday, April 14, 2020 8:00am
Location: Michigan League
Organized By: Department of Learning Health Sciences

This event aims to bring together educational scholars, practitioners,
researchers, and students to share best practices and explore
opportunities for collaboration and innovation around health professions
education and interprofessional education, in particular.
The day’s highlights will include poster presentations, networking, and
exchanging of best practices in implementation of interprofessional education.
We also aim to continue the growth of collaborations across the health science
schools and the broader University of Michigan community and campuses.

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Conference / Symposium Tue, 17 Mar 2020 20:13:50 -0400 2020-04-14T08:00:00-04:00 2020-04-14T13:00:00-04:00 Michigan League Department of Learning Health Sciences Conference / Symposium HPE Day 2019
CANCELLED: Health Professions Education Day (April 14, 2020 8:00am) https://events.umich.edu/event/70516 70516-17602797@events.umich.edu Event Begins: Tuesday, April 14, 2020 8:00am
Location: Michigan League
Organized By: Department of Learning Health Sciences

HPE Day 2020 Cancelled
Based on the University’s guidelines to cancel gatherings of over 100 people until at least April 21 due to the COVID-19 outbreak, we regret to announce that Health Professions Education Day 2020 is cancelled. The event was scheduled to take place on April 14, 2020.

We plan to create an online space where accepted posters can be captured and asynchronous discussion can take place. The details and logistics of this will await resumption of normal business activities. For those of you with accepted poster abstracts, this will include a new deadline for poster PDFs.

Your understanding and flexibility is appreciated. The safety of our faculty, staff, and students is our top priority.


The 6th Annual Health Professions Education Day will be held on Tuesday, April 14, 2020 from 8am - 3pm at the Michigan League. The guest lecturer will be Elena Umland, PharmD.

Agenda
7:30-8:00am: Poster Set-up
8:00-8:30am: Registration and Breakfast
8:30-8:45am: Welcome and Introduction
8:45-9:30am: Keynote Address from Elena Umland, PharmD
9:45-11:15am: Poster Sessions
11:15-11:45am: Awards and Closing Remarks
12:00-1:00pm: Table Topic Lunch
1:00-3:00pm: **Workshop**

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Conference / Symposium Mon, 16 Mar 2020 11:17:13 -0400 2020-04-14T08:00:00-04:00 2020-04-14T15:00:00-04:00 Michigan League Department of Learning Health Sciences Conference / Symposium Elena Umland pic
PhD Defense: Joel Tan (April 14, 2020 2:00pm) https://events.umich.edu/event/73953 73953-18443421@events.umich.edu Event Begins: Tuesday, April 14, 2020 2:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This PhD defense will be taking place via Blue Jeans. Link below.

Blue Jeans: https://bluejeans.com/304616213
Chair: Dr. Xueding Wang

Photoacoustic (PA) imaging is an emerging biomedical imaging modality that combines optical and ultrasound imaging technologies. PA imaging relies on the absorption of electromagnetic energy (usually in the form of visible or near-infrared light) leading to the generation of acoustic waves by thermoelastic expansion, which can be detected with an ultrasound detector. PA imaging can be used to detect endogenous chromophores such as deoxyhemoglobin and oxyhemoglobin, or can be used together with external nanosensors for added functionality. The former is used to measure things like blood oxygenation, while the latter opens up many possibilities for PA imaging, limited only to the availability of optical nanosensors. In this dissertation, I employ the use of PA nanosensors for contrast enhancement and molecular imaging in in vivo small animal cancer models.

In the first section, I introduce a novel PA background reduction technique called the transient triplet differential (TTD) method. The TTD method exploits the fact that phosphorescent dyes possess a triplet state with a unique red-shifted absorption wavelength, distinct from its ordinary singlet state absorption profile. By pumping these dyes into the triplet state and comparing the signal to the unpumped dyes, a differential signal can be obtained which solely originates from these dyes. Since intrinsic chromophores of biological tissue are not able to undergo intersystem crossing and enter the triplet state, the TTD method can facilitate “true” background free molecular imaging by excluding the signals from every other chromophore outside the phosphorescent dye. Here, I demonstrate up to an order of magnitude better sensitivity of the TTD method compared to other existing contrast enhancement techniques in both in vitro experiments and in vivo cancer models.

In the second section, I explore the use of a nanoparticle formulation of a repurposed FDA-approved drug called clofazimine for diagnosis of prostate cancer. Clofazimine nanoparticles have a high optical absorbance at 495 nm and has been known to specifically accumulate in macrophages as they form stable crystal-like inclusions once they are uptaken by macrophages. Due to the presence of tumor associated macrophages, it is expected that clofazimine would accumulate in much higher quantities in the cancerous prostate compared to normal prostates. Here, I show that there was indeed a significantly higher accumulation of clofazimine nanoparticles in cancerous prostates compared to normal prostates in a transgenic mouse model, which was detectable both using histology and ex vivo PA imaging.

In the third and final section, I explore the use of a potassium (K+) nanosensor together with PA imaging in measuring the in vivo K+ distribution in the tumor microenvironment (TME). K+ is the most abundant ion in the body and has recently been shown to be at a significantly higher concentration in the tumor. The reported 5-10 fold elevation (25-50 mM compared to 5 mM) in the tumor has been shown to inhibit immune cell efficacy, and thus immunotherapy. Despite the abundance and importance of K+ in the body, few ways exist to measure it in vivo. In this study, a solvatochromic dye K+ nanoparticle (SDKNP) was used together with PA imaging to quantitatively measure the in vivo distribution of K+ in the TME. Significantly elevated K+ levels were found in the TME, with an average concentration of approximately 29 mM, matching the values found by the previous study. The results were then verified using mass spectrometry.

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Lecture / Discussion Wed, 25 Mar 2020 13:19:15 -0400 2020-04-14T14:00:00-04:00 2020-04-14T15:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Master's Defense: Jonathan Primeaux (April 21, 2020 2:30pm) https://events.umich.edu/event/74331 74331-18633862@events.umich.edu Event Begins: Tuesday, April 21, 2020 2:30pm
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be held via Zoom. The link will be placed below.

Zoom Link: https://umich.zoom.us/j/7013698675

Children with hypoplastic left heart syndrome (HLHS) must undergo multiple surgical stages to reconstruct the anatomy to a sustainable single ventricle system. Stage I palliation, or the Norwood procedure, enables circulation to both pulmonary and systemic vasculature. The aorta is reconstructed and attached to the right ventricle and a fraction of systemic flow is redirected to the pulmonary arteries (PAs) through a systemic-to-pulmonary artery shunt. Despite abundant hemodynamic data available 4-5 months after palliation, data is very scarce immediately following stage I. This data is critical in determining post-operative success. In this work, we combined population data and computational fluid dynamics (CFD) to characterize hemodynamics immediately following stage I (post-stage I) and prior to stage II palliation (pre-stage II). A patient-specific model was constructed as a baseline geometry, which was then scaled to reflect population-based morphological data at both time-points. Population-based hemodynamic data was also used to calibrate each model to reproduce blood flow representative of HLHS patients.

The post-stage I simulation produced a mean PA pressure of 22 mmHg and high-frequency oscillations within the flow field indicating highly disturbed hemodynamics. Despite mean PA pressure dropping to 14 mmHg, the pre-stage II model also produced high-frequency flow components and PA wall shear stress increases. These suboptimal conditions result from the need to ensure adequate PA flow throughout the pre-stage II period, as the shunt becomes relatively smaller compared to the growing patient size. In the future, CFD can be used to optimize shunt design and minimize these suboptimal conditions.

Chair: Dr. Alberto Figueroa

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Lecture / Discussion Fri, 17 Apr 2020 13:05:00 -0400 2020-04-21T14:30:00-04:00 2020-04-21T15:30:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Master's Defense: Xijia Quan (April 21, 2020 3:00pm) https://events.umich.edu/event/74183 74183-18559840@events.umich.edu Event Begins: Tuesday, April 21, 2020 3:00pm
Location:
Organized By: Biomedical Engineering

NOTICE: This event will be held via Blue Jeans. The link will be posted below.

Blue Jeans link: https://bluejeans.com/6788336326

We propose a novel optimization algorithm for radiofrequency (RF) pulse design in magnetic resonance imaging (MRI), that regularizes the magnitude and phase of the target (desired) magnetization pattern separately. This approach may be useful across applications where the relative importance of achieving accurate magnitude or phase excitation varies; for example, saturation pulses "care" only about the magnitude excitation pattern. We apply our new design to the problem of spin "prephasing" in 3D functional MRI using blood-oxygen-level-dependent (BOLD) contrast; spin prephasing pulses can mitigate the signal loss observed near air/tissue boundaries due to the presence of local susceptibility gradients. We show that our algorithm can improve the simulation performance and recover some signal in some regions with steep susceptibility gradients. In all cases, our algorithm shows better phase correction than a conventional design based on minimizing the complex difference between the target and realized patterns. The algorithm is open-source and the computation time is feasible for online applications. In addition, we evaluate the impact of the choice of (initial) excitation k-space trajectories, both in terms of trajectory type (SPINS vs extended KT points) and overall pulse duration.

Chair: Dr. Jon-Fredrik Nielsen

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Lecture / Discussion Thu, 09 Apr 2020 14:11:30 -0400 2020-04-21T15:00:00-04:00 2020-04-21T16:00:00-04:00 Biomedical Engineering Lecture / Discussion BME Logo
PhD Defense: David Martel (April 22, 2020 3:00pm) https://events.umich.edu/event/74201 74201-18568320@events.umich.edu Event Begins: Wednesday, April 22, 2020 3:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be held via Zoom. The link will be provided below.

Zoom: https://umich.zoom.us/j/2019377962

Tinnitus is the disorder of phantom sound perception, while hyperacusis is abnormally increased loudness growth. Tinnitus and hyperacusis are both associated with hearing loss, but hearing loss does not always occur with either condition, implicating central neural activity as the basis for each disorder. Furthermore, while tinnitus and hyperacusis can co-occur, either can occur exclusively, suggesting that separate pathological neural processes underlie each disorder.

Mounting evidence suggests that pathological neural activity in the cochlear nucleus, the first central nucleus in the auditory pathway, underpins hyperacusis and tinnitus. The cochlear nucleus is comprised of a ventral and dorsal subdivision, which have separate principle output neurons with distinct targets. Previous studies have shown that dorsal cochlear nucleus fusiform cells show tinnitus-related increases in spontaneous firing with minimal alterations to sound-evoked responses. In contrast, sound-evoked activity in ventral cochlear nucleus bushy cells is enhanced following noise-overexposure, putatively underlying hyperacusis. While the fusiform-cell contribution to tinnitus has been well characterized with behavioral and electrophysiological studies, the bushy-cell contribution to tinnitus or hyperacusis has been understudied.

This dissertation examines how pathological neural activity in cochlear nucleus circuitry relates to tinnitus and hyperacusis in the following three chapters.

In the first chapter, I characterize the development of a high-throughput tinnitus behavioral model, which combines and optimizes existing paradigms. With this model, I show that animals administered salicylate, a drug that reliably induces tinnitus at high doses in both humans and animals, show behavioral evidence of tinnitus in two separate behavioral tests. Moreover, in these same animals, I show that dorsal-cochlear-nucleus fusiform cells exhibit frequency-specific increases in spontaneous firing activity, consistent with noise-induced tinnitus in animals.

In the second chapter, I show that following noise-overexposure, ventral-cochlear-nucleus bushy cells demonstrate hyperacusis-like neural firing patterns, but not tinnitus-specific increases in spontaneous activity. I contrast the bushy-cell neural activity with established fusiform-cell neural signatures of tinnitus, to highlight the bushy-cell, but not fusiform-cell contribution to hyperacusis. These analyses suggest that tinnitus and hyperacusis likely arise from distinct neural substrates.

In the third chapter, I use computational modelling of the auditory periphery and bushy-cell circuitry to examine potential mechanisms that underlie hyperacusis-like neural firing patterns demonstrated in the second chapter. I then relate enhanced bushy-cell firing patterns to alterations in the auditory brainstem response, a sound-evoked electrical potential generated primarily by bushy cells. Findings in this chapter suggest that there are multiple hyperacusis subtypes, arising from separate mechanisms, which could be diagnosed through fine-tuned alterations to the auditory brainstem response.

Chair: Dr. Susan Shore

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Lecture / Discussion Thu, 09 Apr 2020 14:17:07 -0400 2020-04-22T15:00:00-04:00 2020-04-22T16:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Defense: Analysis of the Dstac Gene, a Novel Regulator of Neuronal Function and Behavior in Drosophila Melanogaster (April 24, 2020 1:30pm) https://events.umich.edu/event/74347 74347-18658199@events.umich.edu Event Begins: Friday, April 24, 2020 1:30pm
Location:
Organized By: Department of Molecular, Cellular, and Developmental Biology

Mentor: John Kuwada

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Workshop / Seminar Thu, 23 Apr 2020 17:57:13 -0400 2020-04-24T13:30:00-04:00 2020-04-24T15:30:00-04:00 Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials and yellow microscope on a blue square
PhD Defense: Richard Youngblood (April 29, 2020 2:00pm) https://events.umich.edu/event/74358 74358-18666222@events.umich.edu Event Begins: Wednesday, April 29, 2020 2:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be held via Blue Jeans. The link will be posted below.

BlueJeans: https://bluejeans.com/855683101

Human pluripotent stem cells (hPSCs) differentiated into complex three-dimensional (3D) structures, referred to as ‘organoids’ due to their organ-like properties, offer ideal platforms to study human development, disease and regeneration. However, studying organ morphogenesis has been hindered by the lack of appropriate culture systems that can spatially enable cellular interactions that are needed for organ formation. Many organoid cultures rely on decellularized extracellular matrices as supportive scaffolds, which are often poorly chemically defined and allow only limited tunability and reproducibility. By contrast, engineered synthetic matrices can be tuned and optimized to mimic the embryo environment in order to enhance development and maturation of organoid cultures. Herein, this work primarily focuses on using synthetic polymer matrices to investigate how the design of biomaterials can guide key interactions guiding stem-cell decisions for the reproducible generation and control of organoid cultures.
Microporous biomaterials comprised of synthetic polymer materials were shown to guide the assembly of pancreatic progenitors into insulin-producing clusters that further developed into islet organoids. The scaffold culture facilitated cell-cell interactions enabled by the scaffold design and supported cell-mediated matrix deposition of extracellular matrix (ECM) proteins associated with the basement membrane of islet cells. Furthermore, when compared to suspension cultures, the scaffold culture showed increased insulin secretion in response to glucose stimulus indicating the development of functional β-cells. By modifying the stage that cells were seeded on scaffolds from pancreatic progenitor to pancreatic endoderm, islet organoids showed increased amounts of insulin secreted per cell. In addition, seeding scaffolds with dense clusters instead of a single suspension minimized cell manipulation during the differentiation, which was shown to be influential to the development of the islet organoids. An engineered insulin reporter further identified how mechanistic changes in vitro influenced function within individual cells by measuring insulin storage and secretion through non-invasive imaging.
hPSC-derived lung organoids (HLOs) were also evaluated for in vivo maturation on biomaterial scaffolds, where HLOs were shown improved tissue structure and cellular differentiation. Investigative studies demonstrated that scaffold pore interconnectivity and polymer degradation contributed to in vivo maturation, the size of the airway structures and the total size of the transplanted tissue. Polymer biomaterials were also developed to modulate local tissue and systemic inflammation through local delivery of human interleukin 4 (hIL-4)-expressing lentivirus. Microporous scaffold culture strategies improve organoid complexity and exert fine control over the system using engineering solutions, thus, allowing the community to build more realistic organoid tools. Taken together, the microporous scaffold culture demonstrates the feasibility to translate organoid culture to the clinic as a biomanufacturing platform.

Chair: Dr. Lonnie Shea

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Lecture / Discussion Tue, 21 Apr 2020 13:21:55 -0400 2020-04-29T14:00:00-04:00 2020-04-29T15:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Master's Defense: Manan Parag Anjaria (April 30, 2020 1:15pm) https://events.umich.edu/event/74435 74435-18714559@events.umich.edu Event Begins: Thursday, April 30, 2020 1:15pm
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be held via Blue Jeans. The link will be provided below.

Blue Jeans Link: https://bluejeans.com/126133694

Individual muscle contributions to facilitate limb motion are altered in people with transtibial amputation. Specifically, proximal muscles on the residual limb and muscles on the intact limb compensate for the lack of plantarflexor muscles on the residual limb. Powered ankle prostheses have been developed to replace the function of the ankle plantarflexor muscles. As powered prostheses can help people with amputation walk faster, and replicate local ankle joint mechanics similar to biological ankles, we expect that muscle activity would also differ when using powered prostheses compared to unpowered prosthesis. Exploring muscle synergies, or the patterns of co-activation of muscles recruited by a single neural command signal, can provide insight into the neural control strategies used to walk with different types of prostheses. The goal of this study was to determine if the use of a powered ankle prosthesis affected muscle coordination and coactivation in comparison to the use of unpowered prosthesis. Nine people with unilateral transtibial amputation and 9 age-matched, non-amputee controls walked on a treadmill while muscle activity from 16 lower limb muscles were collected. Participants with amputation performed two trials, one with an unpowered and one with a powered prosthesis, on the same day. People with transtibial amputation had higher thigh muscle co-contraction when walking with powered prostheses. They also had the same number of synergies in both prostheses as the non-amputee group, which suggests that the complexity of the motor control strategy is not affected by amputation or prosthesis type. The first three synergies in the intact limb were similar, however, the contribution of different muscles to the fourth synergy varied in people with amputation as they used more knee flexors than ankle dorsiflexors in the late swing phase. We also explored the time-varying pattern of the synergies across the gait cycle. There were some phases of the gait cycle where activation profiles for all the synergies were significantly different between the groups with and without amputation. However, there were strong correlations between muscle weightings for each synergy between the groups with and without amputation, with both prostheses. This indicates that they used a similar muscle recruitment strategy. The use of powered prosthesis reduced the compensatory activity of the proximal muscles making the intact limb synergies muscle weightings more similar to healthy individuals with prolonged or delayed activation profiles. The study could not offer any interpretations of the synergies of the residual limb due to lesser muscle activity data available. Future work should be focused including a larger set of muscles including the lumbar muscles and residual leg muscles to get a better look at the muscle synergy.

Chair: Dr. Deanna Gates

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Lecture / Discussion Mon, 27 Apr 2020 13:44:40 -0400 2020-04-30T13:15:00-04:00 2020-04-30T14:15:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
PhD Defense: Xianglong Wang (May 5, 2020 1:00pm) https://events.umich.edu/event/74357 74357-18666221@events.umich.edu Event Begins: Tuesday, May 5, 2020 1:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be via Zoom. The link will be provided below.

Zoom: https://umich.zoom.us/j/99315883529

Biological transport processes often involve a boundary acting as separation of flow, most commonly in transport involving blood-contacting medical devices. The separation of flow creates two different scenarios of mass transport across the interface. No flow exists within the medical device and diffusion governs mass transport; both convection and diffusion exist when flow is present. The added convection creates a large concentration gradient around the interface. Computer simulation of such cases prove to be difficult and require proper shock capturing methods for the solutions to be stable, which is typically lacking in commercial solvers. In this talk, we propose a second-order accurate numerical method for solving the convection-diffusion equation by using a gradient-limited Godunov-type convective flux and the multi-point flux approximation (MPFA) L-Method for the diffusion flux. We applied our solver towards simulation of a nitric oxide-releasing intravascular catheter.

Intravascular catheters are essential for long-term vascular access in both diagnosis and treatment. Use of catheters are associated with risks for infection and thrombosis. Risk management dictates that the catheters to be often replaced on a 3 to 5-day cycle, which is bothersome to both patients and physicians. Nitric oxide (NO) is a potent antimicrobial and antithrombotic agent produced by vascular endothelial cells. The production level in vivo is so low that the physiological effects can only be seen around the endothelial cells. The catheter can incorporate a NO source in two major ways: by impregnating the catheter with NO-releasing compounds such as S-nitroso-N-acetyl penicillamine (SNAP) or using electrochemical reactions to generate NO from nitrites. We applied our solver to both situations to guide the design of the catheter.

Lung edema is often present in patients with end-stage renal disease due to reduced filtration functions of the kidney. These patients require regular dialysis sessions to manage their fluid status. The clinical gold standard to quantify lung edema is to use CT, which exposes patients to high amounts of radiation and is not cost efficient. Fluid management in such patients becomes very challenging without a clear guideline of fluid to be removed during dialysis sessions. Aggressive fluid removal can cause both exacerbations of congestive failure and hypotension resulting from low blood volume.

Recently, reverberations in ultrasound signals, referred to as “lung ultrasound comets” have emerged as a potential quantitative way to measure lung edema. Increased presence of lung comets is associated with higher amounts of pulmonary edema, higher mortality, and more adverse cardiac events. However, the lung comets are often counted by hand by physicians with single frames in lung ultrasound and high subjectivity has been found to exist among the counting by physicians. We applied image processing and neural network techniques as an attempt to provide an objective and accurate measurement of the amount of lung comets present. Our quantitative results are significantly correlated with a few clinical parameters, including diastolic blood pressure and ejection fraction.

Co-Chairs: Dr. Joseph Bull and Dr. Alberto Figueroa

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Lecture / Discussion Tue, 21 Apr 2020 13:16:12 -0400 2020-05-05T13:00:00-04:00 2020-05-05T14:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
RNA Center Journal Club - The architecture of SARS-CoV-2 transcriptome (May 7, 2020 4:00pm) https://events.umich.edu/event/74371 74371-18674250@events.umich.edu Event Begins: Thursday, May 7, 2020 4:00pm
Location:
Organized By: Center for RNA Biomedicine

Link to publication: https://www.cell.com/pb-assets/products/coronavirus/CELL_CELL-D-20-00765.pdf

Link to Zoom meeting: https://umich.zoom.us/j/97186405854

The RNA Journal Club meets to prepare for seminars and engage with their presenters. The Club studies and reviews the articles relating to upcoming talks. It discusses the theory, methodology and findings of a publication to develop questions for its author.

The Club meets monthly and is open to all. The Journal Club meetings are announced here https://rna.umich.edu/events/. Graduate students and post-docs in RNA research are strongly encouraged to participate. The diversity of expertise within the Club makes it particularly engaging as different perspectives are being exchanged.

The Journal Club is organized by the RNA Student & PostDoc Council. The objective of the RNA Student & PostDoc Council is to work collaboratively across disciplines, build a community and generate innovative ideas to advance RNA research and education across the University of Michigan.

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Livestream / Virtual Thu, 07 May 2020 11:47:34 -0400 2020-05-07T16:00:00-04:00 2020-05-07T17:00:00-04:00 Center for RNA Biomedicine Livestream / Virtual logo
Ph.D. Defense: Kevin Hughes (May 8, 2020 10:00am) https://events.umich.edu/event/74436 74436-18714560@events.umich.edu Event Begins: Friday, May 8, 2020 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be held via Blue Jeans. The link will be provided below.

Blue Jeans Link: https://bluejeans.com/302652230

A variety of immunological disorders are characterized by inappropriate responses to innocuous protein. This is particularly relevant in autoimmune disease, allergy, and transplant rejection. For these, the therapeutic options that exist are minimal or involve broadly immunosuppressive regimens which are often characterized by undesirable side effects. This dissertation highlights advances in the design of a biodegradable poly-lactide-co-glycolide (PLG) nanoparticle (NP) platform to provide antigen-specific tolerance in these disease models.

Strategies to incorporate multiple antigens conjugated to bulk PLG were investigated in a murine model of multiple sclerosis with the observation that a minimum antigen loading of 8µg of antigen per mg of nanoparticle was sufficient to induce maximally observed efficacy. Insights gathered from development of these particles were critical to the design of experiments related to food allergy in mice. Importantly, we demonstrate that it is possible to delivery peanut extract via nanoparticles intravenously without induction of anaphylactic response. Prophylactic and therapeutic administration of particles resulted in improved clinical outcomes and reduction in Th2 markers, including IL-4, IL-5, and IL-13. Interestingly, administration of PLG NPs to deliver allergen did not induce skewing of immunological responses towards Th1/Th17, which is a common approach to treat allergy in pre-clinical models and certain clinical immunotherapy regimens. Studies in a murine model of allogeneic skin transplant rejection demonstrated that the method of incorporation of antigen into the PLG NP resulted in statistically significant delay in graft rejection. These studies also demonstrated shortcomings in the platform’s ability to completely prevent rejection, which we hypothesize is the result of an inability to prevent direct rejection.

Development of FasL-conjugated implantable polymeric discs provided an immunologically privileged site on which to transplant islet cells, which may represent an opportunity to supplement tolerogenic therapies like our PLG NPs. A similar polymeric, implantable technology was designed to enable analysis of the function of inflammatory immune cells, a novel finding which has provided a method to monitor disease progression and response to therapy in a murine model of multiple sclerosis. Collectively, this work has provided several novel strategies to improve polymeric nanoparticle therapies and an implantable, biodegradable platform that shows promise as a companion diagnostic for therapies that impact immune function, including PLG NPs.

Chair: Dr. Lonnie Shea

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Lecture / Discussion Mon, 27 Apr 2020 13:54:09 -0400 2020-05-08T10:00:00-04:00 2020-05-08T11:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Defense: Mechanisms of DNA Modification-Dependent Regulation in Gram-Positive Bacteria (May 14, 2020 1:30pm) https://events.umich.edu/event/74591 74591-18845182@events.umich.edu Event Begins: Thursday, May 14, 2020 1:30pm
Location:
Organized By: Department of Molecular, Cellular, and Developmental Biology

Mentor: Lyle Simmons

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Workshop / Seminar Wed, 13 May 2020 18:04:58 -0400 2020-05-14T13:30:00-04:00 2020-05-14T15:30:00-04:00 Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar yellow microscope and MCDB initials on a blue square
Swimming upstream: Overcoming the challenges of gigantic gene expression and lengthy cilia assembly in Drosophila spermatogenesis (May 19, 2020 2:00pm) https://events.umich.edu/event/74576 74576-18833192@events.umich.edu Event Begins: Tuesday, May 19, 2020 2:00pm
Location:
Organized By: Cell & Developmental Biology

We are pleased to welcome Jaclyn Fingerhut to present her dissertation virtually on May 19, 2020.

Hosted by: Yukiko Yamashita, Mentor

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Lecture / Discussion Tue, 12 May 2020 11:46:04 -0400 2020-05-19T14:00:00-04:00 2020-05-19T15:00:00-04:00 Cell & Developmental Biology Lecture / Discussion Swimming upstream: Overcoming the challenges of gigantic gene expression and lengthy cilia assembly in Drosophila spermatogenesis
Webinar: Learning Health Systems in the Time of COVID-19 (June 2, 2020 2:00pm) https://events.umich.edu/event/74564 74564-18825099@events.umich.edu Event Begins: Tuesday, June 2, 2020 2:00pm
Location:
Organized By: Department of Learning Health Sciences

This 90-minute webinar is designed to introduce individuals to the overall concept of learning health systems, focusing on core components of learning cycles and infrastructure. It is appropriate for anyone interested in how health systems function, and particularly for individuals working within health systems. We will use examples that span countries and clinical problems, with special emphasis on the SARS-CoV-2 pandemic.

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Lecture / Discussion Mon, 11 May 2020 11:05:21 -0400 2020-06-02T14:00:00-04:00 2020-06-02T15:30:00-04:00 Department of Learning Health Sciences Lecture / Discussion Corona virus and Collaboratory logo
POSTPONED Sensory representation in the Drosophila brain (June 4, 2020 4:00pm) https://events.umich.edu/event/74776 74776-18994298@events.umich.edu Event Begins: Thursday, June 4, 2020 4:00pm
Location:
Organized By: Department of Molecular, Cellular, and Developmental Biology

This seminar has been postponed due to the re-opening of the BSB for research.
It will occur via Zoom
Contact Stella Bublitz <bublitzs@umich.edu> for the link.

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Workshop / Seminar Mon, 01 Jun 2020 16:26:11 -0400 2020-06-04T16:00:00-04:00 2020-06-04T17:00:00-04:00 Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials and yellow microscope on a blue square
RNA Innovation Seminar, Jeffery Twiss, MD, PhD, Professor, Interim Departmental Chair, SmartState Chair in Childhood Neurotherapeutics, University of South Carolina (June 15, 2020 4:00pm) https://events.umich.edu/event/73583 73583-18263274@events.umich.edu Event Begins: Monday, June 15, 2020 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Jeffery Twiss, MD, PhD, Professor, Interim Departmental Chair, SmartState Chair in Childhood Neurotherapeutics, University of South Carolina

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Lecture / Discussion Thu, 05 Mar 2020 08:43:23 -0500 2020-06-15T16:00:00-04:00 2020-06-15T17:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion lecture
The role of Down syndrome cell adhesion molecule in development and diseases (June 18, 2020 10:00am) https://events.umich.edu/event/74737 74737-18960488@events.umich.edu Event Begins: Thursday, June 18, 2020 10:00am
Location: Off Campus Location
Organized By: Cell & Developmental Biology

We are pleased to announce that Hao Liu will present his dissertation defense on June 18th, 2020 through a live stream virtual seminar!

Dissertation Committee:
Associate Professor Bing Ye, Mentor
Assistant Professor Kenneth Kwan, Chair
Professor Yukiko Yamashita
Assistant Professor Dawen Cai
Associate Professor Ken Inoki

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Lecture / Discussion Thu, 28 May 2020 07:41:08 -0400 2020-06-18T10:00:00-04:00 2020-06-18T11:00:00-04:00 Off Campus Location Cell & Developmental Biology Lecture / Discussion Hao Liu Flyer
PhD Defense: Matthew S. Willsey (June 29, 2020 10:00am) https://events.umich.edu/event/74994 74994-19128257@events.umich.edu Event Begins: Monday, June 29, 2020 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be held via Zoom. The link will be placed below.

Zoom: https://umich.zoom.us/j/91278019863

Many diseases and injuries irreparably harm the brain or spinal cord and result in motor paralysis, widespread sensory deficits, and pain. Often, there are no treatments for these injuries, and therapies revolve around rehabilitation and adapting to the acquired deficits. In this work, we investigate brain machine interfaces (BMIs) as a future therapy to restore sensorimotor function, use BMIs to understand sensorimotor circuits, and use novel imaging algorithms to assess structural damage of somatosensory inputs into the brain.

Brain-controlled robotic arms have progressed rapidly from the first prototype devices in animals; however, these arms are often slow-moving compared to normal hand and arm function. In the first study, we attempt to restore higher-velocity movements during real-time control of virtual fingers using a novel feedforward neural network algorithm to decode the intended motor movement from the brain. In a non-human primate, the neural network decoder was compared with a linear decoder, the ReFIT Kalman filter (RFKF), that we believe represents the state-of-the-art in real-time finger decoding. The neural network decoder outperformed RFKF by acquiring more targets at faster velocities. This neural network architecture may also provide a blueprint for additional advances.

Somatosensory feedback from robotic arms is an important step to improve the realism and overall functioning. The use of somatosensory thalamus was investigated as a site of implantation for a sensory prosthesis in subjects undergoing awake deep brain stimulation surgery (DBS). In this study, electrical stimulation of the thalamus was performed using different stimulation patterns and the evoked sensations were compared. We found that the sensations evoked by bursting (a burst of pulses followed by a rest period) and tonic (regularly repeating pulses) stimulation were often in different anatomic regions and often with differing sensory qualities. These techniques for controlling percept location and quality may be useful in not only in BMI applications but also in DBS therapies to better relieve symptoms and avoid unwanted side effects.

Given the importance of sensory integration in motor functioning, the third study investigated the impact of a pharmacological perturbation on somatosensory content in primary motor cortex measured with Utah arrays implanted in two NHPs. Specifically, during continuous administration of nitrous oxide (N2O), somatosensory content was assessed by using the neural activity in primary motor cortex to classify finger brushings with a cotton-tip applicator. N2O degraded but did not eliminate somatosensory content in motor cortex. These findings provide insight into N2O mechanisms and may lead to further study of somatosensory afferents to motor cortex.

A debilitating facial pain syndrome, called trigeminal neuralgia (TN), is thought to be caused by vascular compression of the sensory root that provides somatosensory feedback from the face. In this final study, magnetic resonance diffusion tensor imaging was used to assess the structural damage of this sensory root. In a retrospective manner, we developed and tested an algorithm that predicted the likelihood of pain relief after surgical treatment of TN. This algorithm could help select patients for surgery with the best chance for pain relief.

Together, these studies advance BMI technologies that attempt to restore realistic function to those with irreparable damage to sensorimotor pathways. Furthermore, using BMIs and novel imaging, this work provides a better understanding of sensorimotor circuits and how sensory pathways can be damaged in disease states.

Co-Chairs: Parag G. Patil and Cynthia A. Chestek

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Lecture / Discussion Thu, 18 Jun 2020 15:24:23 -0400 2020-06-29T10:00:00-04:00 2020-06-29T11:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Precision Health Graduate Certificate - Online Information Session (June 30, 2020 12:00pm) https://events.umich.edu/event/74906 74906-19071330@events.umich.edu Event Begins: Tuesday, June 30, 2020 12:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

The growing field of Precision Health seeks to tailor healthcare for individuals via a multi-disciplinary, data-driven approach.

The Precision Health Graduate Certificate Program has arrived to educate current and future practitioners and researchers in this emerging field so they can become better equipped to customize patient care.

- Only 12 credits of graduate coursework required
- Great opportunity for graduate students to design their own plan
- Network with other Precision Health students and faculty at seminars and professional development workshops
- Mentoring with faculty

The certificate is open to all graduate students enrolled at the University of Michigan.

Register via the registration link on the right beneath the "related links" tab

Questions: PHCertificate@umich.edu

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Livestream / Virtual Thu, 11 Jun 2020 10:45:01 -0400 2020-06-30T12:00:00-04:00 2020-06-30T12:30:00-04:00 Off Campus Location Department of Learning Health Sciences Livestream / Virtual Precision Health logo
PhD Defense: Daniel Quevedo (July 1, 2020 9:30am) https://events.umich.edu/event/74977 74977-19118435@events.umich.edu Event Begins: Wednesday, July 1, 2020 9:30am
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be held digitally via Blue Jeans. The link will be placed below.

BlueJeans: https://bluejeans.com/863787871

Nanomedicine- where a therapeutic is loaded into nanoparticles to increase therapeutic efficiency and improve patient outcomes- has long had the potential to revolutionize medicine. With all of their promise, nanoparticle carrier technologies have yet to make a significant clinical impact, emphasizing the need for new technologies and approaches. In this dissertation, electrohydrodynamic (EHD) co-jetting was used to develop various methods to create novel Synthetic Protein Nanoparticles (SPNPs), which were then applied to the delivery of therapeutic enzymes, and characterized using a microfluidic technique. It was found that SPNPs can be made from various proteins, such as Human Transferrin, Hemoglobin, and others, and that various macromers can be selected, such as a stimuli responsive NHS-Ester based macromer that can detect oxidative environments and show signs of degradation within 30 minutes of being taken up by HeLa cells. SPNPs were then loaded with medically relevant enzymes, such as the antioxidant enzyme catalase. The enzymes showed high activity retention rates, with catalase SPNPs maintaining up to 82% of their original enzymatic activity. Additionally, antibody-targeted catalase SPNPs were able to protect up to 80% of REN cells in an inflammatory disease model. Next, an electrokinetic microfluidic system was adapted for the characterization of SPNPs based on their protein composition and anisotropy, and was able to differentiate bicompartmental particles made from two different proteins from single compartment SPNPs made of an equivalent isotropic mixture of the same two proteins, with a voltage difference of 900 V between the two particle types, in contrast to the 50 V step sizes possible in these systems. Finally, preliminary work was conducted on using a small targeting molecule, meta-acetylenbenzylguanidine (MABG), for the treatment of neuroblastoma, and a system for validating MABG targeting in SK-N-BE(2) cells (a neuroblastoma cell line) was developed. Work done in this dissertation presents the development of multifunctional protein nanocarriers and lays the groundwork for the targeted delivery of active therapeutics using these particles.

Chair: Dr. Joerg Lahann

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Lecture / Discussion Thu, 18 Jun 2020 15:24:54 -0400 2020-07-01T09:30:00-04:00 2020-07-01T10:30:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Kate A. Fitzgerald, PhD, Vice Chair, Research, Department of Medicine, (July 13, 2020 4:00pm) https://events.umich.edu/event/74621 74621-18880949@events.umich.edu Event Begins: Monday, July 13, 2020 4:00pm
Location:
Organized By: Center for RNA Biomedicine

Registration link: https://umich.zoom.us/webinar/register/WN_25jkEySCT6q3UWjxfRU13Q

Keywords: lncRNA, Inante Immunity, Interferon, Antiviral

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Lecture / Discussion Wed, 01 Jul 2020 11:22:18 -0400 2020-07-13T16:00:00-04:00 2020-07-13T17:00:00-04:00 Center for RNA Biomedicine Lecture / Discussion speaker photo
NeuroNetwork for Emerging Therapies Mini Symposium: Complications of COVID -19 (July 14, 2020 9:00am) https://events.umich.edu/event/75202 75202-19330333@events.umich.edu Event Begins: Tuesday, July 14, 2020 9:00am
Location:
Organized By: NeuroNetwork for Emerging Therapies

Join Eva L. Feldman, MD, PhD, Director of the NeuroNetwork for Emerging Therapies, who will moderate a Michigan Medicine all-star mini symposium on Zoom to discuss the systemic complications of COVID-19 in the kidneys, cardiovascular system, metabolism and nervous system. The 30-minute webinar will feature nephrologist Matthias Kretzler, MD; endocrinologist Rodica Pop-Busui, MD, PhD; and cardiologist Salim Hayek, MD.
Join this virtual event at:
https://umich-health.zoom.us/webinar/register/7515947331247/WN_45JRnLCcQgeLWMBMILSFvQ

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Conference / Symposium Tue, 14 Jul 2020 09:50:35 -0400 2020-07-14T09:00:00-04:00 2020-07-14T10:00:00-04:00 NeuroNetwork for Emerging Therapies Conference / Symposium Complications of COVID -19 Mini Symposium
NeuroNetwork for Emerging Therapies Mini Symposium: Complications of COVID -19 (July 14, 2020 9:00am) https://events.umich.edu/event/75202 75202-19330334@events.umich.edu Event Begins: Tuesday, July 14, 2020 9:00am
Location:
Organized By: NeuroNetwork for Emerging Therapies

Join Eva L. Feldman, MD, PhD, Director of the NeuroNetwork for Emerging Therapies, who will moderate a Michigan Medicine all-star mini symposium on Zoom to discuss the systemic complications of COVID-19 in the kidneys, cardiovascular system, metabolism and nervous system. The 30-minute webinar will feature nephrologist Matthias Kretzler, MD; endocrinologist Rodica Pop-Busui, MD, PhD; and cardiologist Salim Hayek, MD.
Join this virtual event at:
https://umich-health.zoom.us/webinar/register/7515947331247/WN_45JRnLCcQgeLWMBMILSFvQ

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Conference / Symposium Tue, 14 Jul 2020 09:50:35 -0400 2020-07-14T09:00:00-04:00 2020-07-14T10:00:00-04:00 NeuroNetwork for Emerging Therapies Conference / Symposium Complications of COVID -19 Mini Symposium
BioArtography Virtual Art Fair Sale through July 21! (July 16, 2020 12:00am) https://events.umich.edu/event/75240 75240-19342129@events.umich.edu Event Begins: Thursday, July 16, 2020 12:00am
Location: Off Campus Location
Organized By: BioArtography

BioArtography is having a Virtual Art Fair through July 21! An exciting collection of new images for 2020 will be launched & returning favorites are still available!

Specials will be offered on our website bioartography.com including 15% off and free U.S. shipping on note cards, prints, framed art, gallery wrap canvas and frameless glass!

Follow @bioartography on Twitter , Instagram and Facebook to keep up with all the details!

Proceeds from the sale of this work help support the training of our next generation of researchers!

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Exhibition Mon, 20 Jul 2020 12:13:02 -0400 2020-07-16T00:00:00-04:00 2020-07-16T23:59:00-04:00 Off Campus Location BioArtography Exhibition BioArtography 2020 Collection
BioArtography Virtual Art Fair Sale through July 21! (July 17, 2020 12:00am) https://events.umich.edu/event/75240 75240-19342130@events.umich.edu Event Begins: Friday, July 17, 2020 12:00am
Location: Off Campus Location
Organized By: BioArtography

BioArtography is having a Virtual Art Fair through July 21! An exciting collection of new images for 2020 will be launched & returning favorites are still available!

Specials will be offered on our website bioartography.com including 15% off and free U.S. shipping on note cards, prints, framed art, gallery wrap canvas and frameless glass!

Follow @bioartography on Twitter , Instagram and Facebook to keep up with all the details!

Proceeds from the sale of this work help support the training of our next generation of researchers!

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Exhibition Mon, 20 Jul 2020 12:13:02 -0400 2020-07-17T00:00:00-04:00 2020-07-17T23:59:00-04:00 Off Campus Location BioArtography Exhibition BioArtography 2020 Collection
BioArtography Virtual Art Fair Sale through July 21! (July 18, 2020 12:00am) https://events.umich.edu/event/75240 75240-19342131@events.umich.edu Event Begins: Saturday, July 18, 2020 12:00am
Location: Off Campus Location
Organized By: BioArtography

BioArtography is having a Virtual Art Fair through July 21! An exciting collection of new images for 2020 will be launched & returning favorites are still available!

Specials will be offered on our website bioartography.com including 15% off and free U.S. shipping on note cards, prints, framed art, gallery wrap canvas and frameless glass!

Follow @bioartography on Twitter , Instagram and Facebook to keep up with all the details!

Proceeds from the sale of this work help support the training of our next generation of researchers!

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Exhibition Mon, 20 Jul 2020 12:13:02 -0400 2020-07-18T00:00:00-04:00 2020-07-18T23:59:00-04:00 Off Campus Location BioArtography Exhibition BioArtography 2020 Collection
BioArtography Virtual Art Fair Sale through July 21! (July 19, 2020 12:00am) https://events.umich.edu/event/75240 75240-19342132@events.umich.edu Event Begins: Sunday, July 19, 2020 12:00am
Location: Off Campus Location
Organized By: BioArtography

BioArtography is having a Virtual Art Fair through July 21! An exciting collection of new images for 2020 will be launched & returning favorites are still available!

Specials will be offered on our website bioartography.com including 15% off and free U.S. shipping on note cards, prints, framed art, gallery wrap canvas and frameless glass!

Follow @bioartography on Twitter , Instagram and Facebook to keep up with all the details!

Proceeds from the sale of this work help support the training of our next generation of researchers!

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Exhibition Mon, 20 Jul 2020 12:13:02 -0400 2020-07-19T00:00:00-04:00 2020-07-19T23:59:00-04:00 Off Campus Location BioArtography Exhibition BioArtography 2020 Collection
BioArtography Virtual Art Fair Sale through July 21! (July 20, 2020 12:00am) https://events.umich.edu/event/75240 75240-19379434@events.umich.edu Event Begins: Monday, July 20, 2020 12:00am
Location:
Organized By: BioArtography

BioArtography is having a Virtual Art Fair through July 21! An exciting collection of new images for 2020 will be launched & returning favorites are still available!

Specials will be offered on our website bioartography.com including 15% off and free U.S. shipping on note cards, prints, framed art, gallery wrap canvas and frameless glass!

Follow @bioartography on Twitter , Instagram and Facebook to keep up with all the details!

Proceeds from the sale of this work help support the training of our next generation of researchers!

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Exhibition Mon, 20 Jul 2020 12:13:02 -0400 2020-07-20T00:00:00-04:00 2020-07-20T23:59:00-04:00 BioArtography Exhibition BioArtography 2020 Collection
Philip S. Brachman Memorial Lecture (July 20, 2020 2:00pm) https://events.umich.edu/event/75242 75242-19379439@events.umich.edu Event Begins: Monday, July 20, 2020 2:00pm
Location:
Organized By: School of Public Health

Wednesday, July 22 at 12:15 p.m.
Topic: Triangulating Evidence from Different Methods to Improve Causal Understanding
https://umich.zoom.us/j/99552023212

Join from a PC, Mac, iPad, iPhone or Android device:
Please click this URL to join. https://umich.zoom.us/j/99552023212
Password: 354712
Description: Wednesday, July 22 at 12:15 p.m.

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Conference / Symposium Mon, 20 Jul 2020 14:18:20 -0400 2020-07-20T14:00:00-04:00 2020-07-20T15:00:00-04:00 School of Public Health Conference / Symposium Brachman Lecture
BioArtography Virtual Art Fair Sale through July 21! (July 21, 2020 12:00am) https://events.umich.edu/event/75240 75240-19379435@events.umich.edu Event Begins: Tuesday, July 21, 2020 12:00am
Location:
Organized By: BioArtography

BioArtography is having a Virtual Art Fair through July 21! An exciting collection of new images for 2020 will be launched & returning favorites are still available!

Specials will be offered on our website bioartography.com including 15% off and free U.S. shipping on note cards, prints, framed art, gallery wrap canvas and frameless glass!

Follow @bioartography on Twitter , Instagram and Facebook to keep up with all the details!

Proceeds from the sale of this work help support the training of our next generation of researchers!

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Exhibition Mon, 20 Jul 2020 12:13:02 -0400 2020-07-21T00:00:00-04:00 2020-07-21T23:59:00-04:00 BioArtography Exhibition BioArtography 2020 Collection
Philip S. Brachman Memorial Lecture (July 22, 2020 12:15pm) https://events.umich.edu/event/75242 75242-19348012@events.umich.edu Event Begins: Wednesday, July 22, 2020 12:15pm
Location:
Organized By: School of Public Health

Wednesday, July 22 at 12:15 p.m.
Topic: Triangulating Evidence from Different Methods to Improve Causal Understanding
https://umich.zoom.us/j/99552023212

Join from a PC, Mac, iPad, iPhone or Android device:
Please click this URL to join. https://umich.zoom.us/j/99552023212
Password: 354712
Description: Wednesday, July 22 at 12:15 p.m.

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Conference / Symposium Mon, 20 Jul 2020 14:18:20 -0400 2020-07-22T12:15:00-04:00 2020-07-22T13:30:00-04:00 School of Public Health Conference / Symposium Brachman Lecture
PhD Defense: Charles Lu (July 23, 2020 2:00pm) https://events.umich.edu/event/75199 75199-19324453@events.umich.edu Event Begins: Thursday, July 23, 2020 2:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be held via Zoom. The link will be placed below.

Zoom: https://umich-health.zoom.us/j/95667535536

Therapeutic neuromodulation has an established history for clinical indications, such as deep brain stimulation for movement disorders and spinal cord stimulation for pain, despite an incomplete understanding of its mechanism of action. Novel neuroprosthetics have the potential to enable wholly new therapies, including sensory restoration and treatment of affective disorders. In order to fully realize the potential of these interventions, precise parameterization of stimulation, informed by better understanding of underlying processes, is required. This dissertation explores the temporal and spatial determinants of outcomes for stimulation within the context of clinical and experimental sensorimotor neuromodulation.

The first study of the dissertation defines a new functional target for subthalamic deep brain stimulation for Parkinson disease treatment. While optimal sites of stimulation are often analyzed as discrete points in space, therapeutic tissue activation is known to activate entire volumes of surrounding tissue. To identify markers of these volumes, we used machine learning tools to identify associations between features of wideband neural recordings and regions of clinically validated stimulation regions derived from patient-specific tissue activation models. The study identified several electrophysiological markers of therapeutic activation regions, providing a tool for efficient optimization of stimulation programming.

Despite the importance of spatially precise stimulation, conventional stereotactic methods are limited by intrinsic sources of error. The second study assessed a novel form of lead localization utilizing local impedance at deep brain sites. We demonstrated that in vivo impedance measurements generally match patterns observed in electrostatic simulations and showed that these values can be efficiently estimated using diffusion tensor data. Impedances measured using a clinical macroelectrode provided spatial information at the resolution of millimeters and could be used to roughly localize deep brain trajectories, presenting a prototype method to complement existing targeting technologies.

The final study evaluated a novel form of deep brain stimulation for modulation of pain. Previous rodent studies show that stimulation of zona incerta can provide analgesic effect, and clinical evidence suggests that stimulation of a nearby nucleus, nominally used to treat motor manifestations of Parkinson disease, often also results in improvement of pain symptoms. We directly tested the analgesic effect of zona incerta stimulation in humans and demonstrated that stimulation at the physiological spiking frequency of zona incerta selectively reduces perceived heat pain.

Chair: Dr. Parag G. Patil

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Lecture / Discussion Mon, 13 Jul 2020 15:30:00 -0400 2020-07-23T14:00:00-04:00 2020-07-23T15:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
PhD Defense: Benjamin Juliar (July 28, 2020 1:00pm) https://events.umich.edu/event/75205 75205-19330337@events.umich.edu Event Begins: Tuesday, July 28, 2020 1:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be held via BlueJeans. The link will be placed below.

BlueJeans Link: https://bluejeans.com/358462383

Engineering large viable tissues requires techniques for encouraging rapid capillary bed formation to prevent necrosis. A convenient means of creating this micro-vascular network is through spontaneous neovascularization, which occurs when endothelial cells (ECs) and supportive stromal cells are co-encapsulated within a variety of hydrogel-based extracellular matrices (ECM) and self-assemble into an interconnected network of endothelial tubules. Although this is a robust phenomenon, the environmental and cell-specific determinants that affect the rate and quality of micro-vascular network formation still require additional characterization to improve clinical translatability. This thesis investigates how the proteolytic susceptibility of engineered matrices effects neovascular self-assembly in poly(ethylene glycol) (PEG) hydrogels and provides characterization of changes to matrix mechanics that accompany neovascular morphogenesis in fibrin and PEG hydrogels.

Proteolytic ECM remodeling is essential for the process of capillary morphogenesis. Pharmacological inhibitor studies suggested a role for both matrix metalloproteinases (MMP)- and plasmin-mediated mechanisms of ECM remodeling in an EC-fibroblast co-culture model of vasculogenesis in fibrin. To further investigate the potential contribution of plasmin mediated matrix degradation in facilitating capillary morphogenesis we employed PEG hydrogels engineered with proteolytic specificity to either MMPs, plasmin, or both. Although fibroblasts spread in plasmin-selective hydrogels, we only observed robust capillary morphogenesis in MMP-sensitive matrices, with no added benefit in dual susceptible hydrogels. Enhanced capillary morphogenesis was observed, however, in PEG hydrogels engineered with increased susceptibility to MMPs without altering proteolytic selectivity or hydrogel mechanical properties. These findings highlight the critical importance of MMP-mediated ECM degradation during vasculogenesis and justify the preferential selection of MMP-degradable peptide crosslinkers in the design of synthetic hydrogels used to promote vascularization.

Matrix stiffness is a well-established cue in cellular morphogenesis, however, the converse effect of cellular remodeling on environmental mechanics is comparatively under characterized. In fibrin hydrogels, we applied traditional bulk rheology and laser tweezers-based active microrheology to demonstrate that both ECs and fibroblasts progressively stiffen the ECM across length scales, with the changes in bulk properties dominated by fibroblasts. Despite a lack of fibrillar architecture, a similar stiffening effect was observed in MMP-degradable PEG hydrogels. This stiffening tightly correlated with degree of vessel formation and critically depended on active cellular contractility. To a lesser degree, deposition of ECM proteins also appeared to contribute to progressive hydrogel stiffening. Blocking cell-mediated hydrogel degradation abolished stiffening, demonstrating that matrix metalloproteinase (MMP)-mediated remodeling is required for stiffening to occur. EC co-culture with mesenchymal stem cells (MSCs) in PEG resulted in reduced vessel formation compared to fibroblast co-cultures and no change in hydrogel mechanics over time. The correlation between matrix stiffening and enhanced vessel formation, and dependence on cellular contractility, suggests differences in vessel formation between fibroblasts and MSCs may be partially mediated by differences in cellular contractility. Collectively, these findings provide a deeper understanding of mechanobiological effects during capillary morphogenesis and highlight the dynamic reciprocity between cells and their mechanical environment.

Chair: Dr. Andrew Putnam

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Lecture / Discussion Tue, 14 Jul 2020 11:02:36 -0400 2020-07-28T13:00:00-04:00 2020-07-28T14:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
LHS Collaboratory Webinar - Global LHS for COVID-19 (July 29, 2020 10:00am) https://events.umich.edu/event/75087 75087-19214577@events.umich.edu Event Begins: Wednesday, July 29, 2020 10:00am
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Please join us for this special webinar session on Wednesday, July 29, 2020 from 10:00 am - 11:30 pm EDT.  Registration: https://umich-health.zoom.us/webinar/register/WN_wVDWLBm5QYK79DVK8Tb7_w

This 90-minute webinar is designed to share the work of an international collaboration to develop the foundation for a global Learning Health System addressing COVID-19 and future public health crises. Presenters will share lessons learned from Italy, Spain and the United States, including describing a proposed international comprehensive systemic framework for collection, management, and
analysis of high-quality data to inform decisions in managing the clinical response and social measures to overcome the COVID-19 pandemic. Additionally, presenters will discuss how the results of a pilot project currently under development may illuminate a collaborative path forward for local, regional, and national public health stakeholders worldwide.

Perspectives from Italy:  Paolo Stocco

Perspectives from Spain: Borja Sanchez Garcia, Pablo Rivero, Francisco Ros, Esther Gil Zorzo 

Perspectives from the USA: Charles P. Friedman, Rebecca Kush, Joshua C. Rubin, Douglas Van Houweling

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Lecture / Discussion Mon, 29 Jun 2020 15:22:14 -0400 2020-07-29T10:00:00-04:00 2020-07-29T11:30:00-04:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion LHS Collaboratory Logo-globe
PhD Defense: Katy Norman (July 30, 2020 10:00am) https://events.umich.edu/event/75267 75267-19395124@events.umich.edu Event Begins: Thursday, July 30, 2020 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be held via BlueJeans. The link will be posted below.

BlueJeans: https://bluejeans.com/516255948

Mucosal surfaces in the lung interface with the outside environment for breathing purposes, but also provide the first line of defense against invading pathogens. The intricate balance of effective immune protection at the pulmonary epithelium without problematic inflammation is not well understood, but is an important consideration in complex lung diseases such as idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD). Although IPF is a fibrotic interstitial lung disease of unknown origin and COPD is an obstructive lung disease, they do share some similarities. Both are heterogeneous and progressive in nature, have no cure and few treatment options, advance through unknown mechanisms, and involve an aberrant immune response. As research has focused into the role the immune system plays in IPF and COPD, it has become clear that disease progression is caused by a complex dysregulation of immune factors and cells across the tissue compartments of the lungs and blood.

Data-driven modeling approaches offer the opportunity to infer protein interaction networks, which are able to identify diagnostic and prognostic biomarkers and also serve as the basis for new insight into systems-level mechanisms that define a disease state. Additionally, these approaches are able to integrate data from across multiple tissue compartments, allowing for a more holistic picture of a disease to be formed. Here, we have applied data-driven modeling approaches including partial least squares discriminant analysis, principal component analysis, decision tree analysis, and hierarchical clustering to high-throughput cell and cytokine measurements from human blood and lung samples to gain systems-level insight into IPF and COPD.

Overall we found that these approaches were useful for identifying signatures of proteins that differentiated disease state and progression better than current classifiers. We also found that integrating protein and cell measurements across tissue compartments generally improved classification and was useful for generating new mechanistic insight into progression and exacerbation events. In evaluating IPF progression, we showed that the blood proteome of progressors, but not of non-progressors, changes over time, and that our data-driven modeling techniques were able to capture these changes. Curiously, our models showed that complement system components may be associated with both COPD and IPF disease progression. Lastly, though our analysis suggested that circulating blood cytokines were not useful for differentiating disease state or progression, preliminary work suggested that cell-cell communication networks arising from stimulated peripheral blood proteins may be more useful for classification and gaining mechanistic insight from minimally invasive blood samples. Overall, we believe that this approach will be useful for studying the mucosal immune response present in other diseases that are also progressive or heterogeneous in nature.

Chair: Dr. Kelly Arnold

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Lecture / Discussion Wed, 22 Jul 2020 16:19:44 -0400 2020-07-30T10:00:00-04:00 2020-07-30T11:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Karle Symposium (July 31, 2020 9:00am) https://events.umich.edu/event/74925 74925-19083114@events.umich.edu Event Begins: Friday, July 31, 2020 9:00am
Location:
Organized By: Department of Chemistry

Designed and run by graduate students, the Isabella and Jerome Karle Symposium serves as a venue for sharing exciting research taking place within the Department of Chemistry.

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Workshop / Seminar Fri, 12 Jun 2020 18:06:19 -0400 2020-07-31T09:00:00-04:00 2020-07-31T17:00:00-04:00 Department of Chemistry Workshop / Seminar
Tissue-Specific Roles for Hedgehog Co-Receptors During Vertebrate Embryogenesis (July 31, 2020 1:00pm) https://events.umich.edu/event/74735 74735-18960487@events.umich.edu Event Begins: Friday, July 31, 2020 1:00pm
Location: Off Campus Location
Organized By: Cell & Developmental Biology

We are pleased to announce that Martha Echevarria will present her dissertation defense on July 31st, 2020 through a live stream virtual seminar!

Dissertation Committee:
Associate Professor, Benjamin Allen, Mentor
Professor, Deneen M. Wellik, Co-Chair
Assistant Professor Jason Spence, Co-Chair
Associate Professor, Marina Pasca Di Magliano
Professor Vesa M. Kaartinen

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Livestream / Virtual Thu, 28 May 2020 07:22:24 -0400 2020-07-31T13:00:00-04:00 2020-07-31T14:00:00-04:00 Off Campus Location Cell & Developmental Biology Livestream / Virtual Martha Echevarria Dissertation Defense
PhD Defense: Josiah Simeth (August 5, 2020 2:00pm) https://events.umich.edu/event/75278 75278-19402991@events.umich.edu Event Begins: Wednesday, August 5, 2020 2:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Notice: This event will be held via BlueJeans. The link will be placed below.

BlueJeans: https://bluejeans.com/715371816

Measures of regional and global liver function are critical in guiding treatments for intrahepatic cancers, and liver function is a dominant factor in the survival of patients with hepatocellular carcinoma (HCC). Global and regional liver function assessments are important for defining the magnitude and spatial distribution of radiation dose to preserve functional liver parenchyma and reduce incidence of hepatotoxicity from radiation therapy (RT) for intrahepatic cancer treatment. This individualized liver function-guided RT strategy is critical for patients with heterogeneous and poor liver function, often observed in cirrhotic patients treated for HCC. Dynamic gadoxetic-acid enhanced (DGAE) magnetic resonance imaging (MRI) allows investigation of liver function through observation of the uptake of contrast agent into the hepatocytes.

This work seeks to determine if gadoxetic uptake rate can be used as a reliable measure of liver function, and to develop robust methods for uptake estimation with an interest in the therapeutic application of this knowledge in the case of intrahepatic cancers. Since voxel-by voxel fitting of the preexisting nonlinear dual-input two-compartment model is highly susceptible to over fitting, and highly dependent on data that is both temporally very well characterized and low in noise, this work proposes and validates a new model for quantifying the voxel-wise uptake rate of gadoxetic acid as a measure of regional liver function. This linearized single-input two-compartment (LSITC) model is a linearization of the pre-existing dual-input model but is designed to perform uptake quantification in a more robust, computationally simpler, and much faster manner. The method is validated against the preexisting dual-input model for both real and simulated data. Simulations are used to investigate the effects of noise as well as issues related to the sampling of the arterial peak in the characteristic input functions of DGAE MRI.

Further validation explores the relationship between gadoxetic acid uptake rate and two well established global measures of liver function, namely: Indocyanine Green retention (ICGR) and Albumin-Bilirubin (ALBI) score. This work also establishes the relationships between these scores and imaging derived measures of whole liver function using uptake rate. Additionally, the same comparisons are performed for portal venous perfusion, a pharmacokinetic parameter that has been observed to correlate with function, and has been used as a guide for individualized liver function-guided RT. For the patients assessed, gadoxetic acid uptake rate performs significantly better as a predictor of whole liver function than portal venous perfusion.
This work also investigates the possible gains that could be introduced through use of gadoxetic uptake rate maps in the creation of function-guided RT plans. To this end, plans were created using both perfusion and uptake, and both were compared to plans that did not use functional guidance. While the plans were generally broadly similar, significant differences were observed in patients with severely compromised uptake that did not correspond with compromised perfusion.

This dissertation also deals with the problem of quantifying uptake rate in suboptimal very temporally sparse or short DGAE MRI acquisitions. In addition to testing the limits of the LSITC model for these limited datasets (both realistic and extreme), a neural network-based approach to quantification of uptake rate is developed, allowing for increased robustness over current models.

Chair: Dr. Yue Cao

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Lecture / Discussion Thu, 23 Jul 2020 17:51:41 -0400 2020-08-05T14:00:00-04:00 2020-08-05T15:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Defense: Building the Biofilm Matrix: Gene Regulation and Cell Organization (August 6, 2020 1:00pm) https://events.umich.edu/event/75482 75482-19505243@events.umich.edu Event Begins: Thursday, August 6, 2020 1:00pm
Location: Off Campus Location
Organized By: Department of Molecular, Cellular, and Developmental Biology

Mentor: Matt Chapman

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Workshop / Seminar Wed, 05 Aug 2020 14:08:34 -0400 2020-08-06T13:00:00-04:00 2020-08-06T15:00:00-04:00 Off Campus Location Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow initials MCDB and cartoon of a microscope on a blue background
NeuroNetwork for Emerging Therapies Mini Symposium: Complications of COVID -19 (August 6, 2020 2:00pm) https://events.umich.edu/event/75202 75202-19330332@events.umich.edu Event Begins: Thursday, August 6, 2020 2:00pm
Location: Off Campus Location
Organized By: NeuroNetwork for Emerging Therapies

Join Eva L. Feldman, MD, PhD, Director of the NeuroNetwork for Emerging Therapies, who will moderate a Michigan Medicine all-star mini symposium on Zoom to discuss the systemic complications of COVID-19 in the kidneys, cardiovascular system, metabolism and nervous system. The 30-minute webinar will feature nephrologist Matthias Kretzler, MD; endocrinologist Rodica Pop-Busui, MD, PhD; and cardiologist Salim Hayek, MD.
Join this virtual event at:
https://umich-health.zoom.us/webinar/register/7515947331247/WN_45JRnLCcQgeLWMBMILSFvQ

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Conference / Symposium Tue, 14 Jul 2020 09:50:35 -0400 2020-08-06T14:00:00-04:00 2020-08-06T14:30:00-04:00 Off Campus Location NeuroNetwork for Emerging Therapies Conference / Symposium Complications of COVID -19 Mini Symposium
PhD Defense: Ziwen Zhu (August 26, 2020 9:30am) https://events.umich.edu/event/75720 75720-19576537@events.umich.edu Event Begins: Wednesday, August 26, 2020 9:30am
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be held via Zoom. The link will be placed below.

Zoom: umich.zoom.us/j/92149340369

Branched Chain amino acids (BCAAs) play an essential role in cell metabolism supplying both carbon and nitrogen in pancreatic cancers, and their increased levels have been associated with increased risk of pancreatic ductal adenocarcinomas (PDACs). It remains unclear how stromal cells regulate BCAA metabolism in PDAC cells and how mutualistic determinants control BCAA metabolism in the tumor milieu. In chapter 1, we present an overview of PDAC biology, tumor microenvironment (TME), altered cancer metabolism and BCAA metabolism. In chapter 2, we uncover differential gene expression of enzymes involved in BCAA metabolism accompanied by distinct catabolic, oxidative, and protein turnover fluxes between cancer-associated fibroblasts (CAFs) and cancer cells with a marked branched-chain keto acids (BCKA)-addiction in PDAC cells. In chapter 3, we showed that cancer-induced stromal reprogramming fuels this BCKA-addiction. We then show the functions of BCAT2 and DBT in the PDAC cells in chapters 3 and 4. We identify BCAT1 as the BCKA regulator in CAFs in chapter 5. In chapter 6, we dictated the internalization of the extracellular matrix from the tumor microenvironment to supply amino acid precursors for BCKA secretion by CAFs. We also showed that the TGF-β/SMAD5 axis directly targets BCAT1 in CAFs in chapter 7. In chapter 8, we validate the in vitro results in human patient-derived circulating tumor cells (CTCs) model. Furthermore, the same results were also validated in PDAC tissue slices, which recapitulate tumor heterogeneity and mimic the in vivo microenvironment in chapter 9. We conclude this manuscript with chapter 10 in which we propose future studies and present directions towards pancreatic cancer research. In summary, our findings reveal therapeutically actionable targets in stromal and cancer cells to regulate the symbiotic BCAA coupling among the cellular constituents of the PDAC microenvironment.

Chair: Dr. Deepak Nagrath

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Lecture / Discussion Fri, 14 Aug 2020 12:02:15 -0400 2020-08-26T09:30:00-04:00 2020-08-26T10:30:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Mechanisms of Coat Assembly and Regulation in Membrane Trafficking- Department of Biological Chemistry Seminar (September 8, 2020 12:00pm) https://events.umich.edu/event/76167 76167-19671607@events.umich.edu Event Begins: Tuesday, September 8, 2020 12:00pm
Location: Off Campus Location
Organized By: Biological Chemistry

Dr. Lauren Parker Jackson will give the Department of Biological Chemistry virtual seminar on Tuesday September 8th, 2020. You must have a University of Michigan email address to join the webinar.

Virtual Seminar: https://umich-health.zoom.us/j/91254715072

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Workshop / Seminar Wed, 26 Aug 2020 12:31:06 -0400 2020-09-08T12:00:00-04:00 2020-09-08T13:00:00-04:00 Off Campus Location Biological Chemistry Workshop / Seminar Parker-Jackson
DCMB / CCMB Weekly Seminar Series (September 9, 2020 4:00pm) https://events.umich.edu/event/76946 76946-19780535@events.umich.edu Event Begins: Wednesday, September 9, 2020 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract: Birth defects that interfere with craniofacial development can result in cognitive, neurosensory, and neuroendocrine defects that create life-long burdens for care. The forebrain, midbrain, hindbrain, five facial prominences, and pituitary gland develop between the first and second month of gestation in humans. Genetic defects that disrupt these processes cause a spectrum of disorders that range from holoprosencephaly (HPE) and septo-optic dysplasia (SOD) to pituitary hormone deficiencies. We screened a large cohort of Argentinean patients with congenital hypopituitarism and related disorders for mutations in known genes and identified novel pathogenic variants and examples of digenic disease. However, the majority of patients did not receive a molecular diagnosis, indicating the high degree of genetic complexity underlying these disorders and the need for additional gene discovery. The majority of known hypopituitarism genes were discovered through basic research in pituitary cell lines and mutant mice. To identify novel regulatory genes for pituitary organogenesis we analyzed differential binding of a key pituitary-specific transcription factor, POU1F1, in cell lines that represent pituitary progenitors and differentiated cells. We discovered that POU1F1 binding is associated with bZIP transcription factors in progenitors and with bHLH factors in differentiated cells. We also applied single cell RNA sequencing technology to analyze gene expression during pituitary organogenesis and discovered novel transcription factors that are candidates for driving cell specification as well as unique, rare cell types that are likely differentiation intermediates. Bioinformatic analyses have played key roles in advancing our knowledge of neuroendocrine birth defects and normal pituitary organogenesis.

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Lecture / Discussion Wed, 09 Sep 2020 08:26:42 -0400 2020-09-09T16:00:00-04:00 2020-09-09T17:00:00-04:00 Off Campus Location DCMB Seminar Series Lecture / Discussion Sally Camper, Ph.D., Margery Shaw Distinguished University Professor of Human Genetics, Professor of Internal Medicine, University of Michigan
RNA Collaborative Seminar featuring: Sue Hammoud, Human Genetics & Justin Colacino, Environmental Health Sciences (September 9, 2020 4:00pm) https://events.umich.edu/event/75865 75865-19615931@events.umich.edu Event Begins: Wednesday, September 9, 2020 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

ZOOM REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_GjVNcoWtRG6OkzxSDmfb8A

"Same Same Different: Single cell RNAseq identifies conserved and divergent features of mammalian spermatogenesis"
Sue Hammoud, Ph.D.
Assistant Professor of Human Genetics
Website: https://hammoud.lab.medicine.umich.edu/

~and~

"Single cell transcriptomic profiling to understand breast stem cell heterogeneity in development and cancer disparities"
Justin Colacino. Ph.D.
Assistant Professor of Environmental Health Sciences
Website: https://www.colacinolab.com/

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Lecture / Discussion Wed, 26 Aug 2020 11:44:32 -0400 2020-09-09T16:00:00-04:00 2020-09-09T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion RNA Collaborative
Identifying Emergency Funds and How to Advocate for Making Room in Your Financial Aid Package (September 11, 2020 2:00pm) https://events.umich.edu/event/75507 75507-19513173@events.umich.edu Event Begins: Friday, September 11, 2020 2:00pm
Location: Off Campus Location
Organized By: CEW+

Advance registration is required; look for the Zoom link at the bottom of your confirmation email after registering.

This session will provide information about how you can seek emergency funds should you experience an emergency situation or one-time, unusual, unforeseen expense while in school. Information about the types of situations that qualify for emergency funds and where to seek funding will be covered during this presentation.

RSVP HERE: http://www.cew.umich.edu/events/identifying-emergency-funds-and-how-to-advocate-for-making-room-in-your-financial-aid-package

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Livestream / Virtual Tue, 18 Aug 2020 14:02:34 -0400 2020-09-11T14:00:00-04:00 2020-09-11T15:00:00-04:00 Off Campus Location CEW+ Livestream / Virtual A jar of spilled change
What's New in DNA Replication? Department of Biological Chemistry Seminar/Rowena Matthews Lecture (September 15, 2020 12:00pm) https://events.umich.edu/event/76176 76176-19671609@events.umich.edu Event Begins: Tuesday, September 15, 2020 12:00pm
Location: Off Campus Location
Organized By: Biological Chemistry

Dr. Michael O'Donnell will give the Department of Biological Chemistry virtual Rowena Matthews Lectureship on Tuesday September 15th, 2020. You must have a University of Michigan email address to join the webinar.

Virtual Seminar: https://umich-health.zoom.us/j/91254715072

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Workshop / Seminar Wed, 26 Aug 2020 12:34:58 -0400 2020-09-15T12:00:00-04:00 2020-09-15T13:00:00-04:00 Off Campus Location Biological Chemistry Workshop / Seminar O'Donnell
LHS Collaboratory Seminar Series Virtual Kick-Off: Academic Medical Centers as Learning Health Systems (September 17, 2020 9:00am) https://events.umich.edu/event/75856 75856-19615923@events.umich.edu Event Begins: Thursday, September 17, 2020 9:00am
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Learning Health Systems (LHS) methods are now being implemented in interesting and varying ways by academic health centers and their clinical and translational science institutes across the country.
According to the Agency for Healthcare Research and Quality (AHRQ), the following are key attributes of Learning Health
Systems:

• Having leaders who are committed to a culture of continuous learning and improvement
• Systematically gathering and applying evidence in real-time to guide care
• Employing IT methods to share new evidence with clinicians to improve decision-making
• Promoting the inclusion of patients as vital members of the learning team
• Capturing and analyzing data and care experiences to improve care
• Continually assessing outcomes, refining processes and training to create a feedback cycle for learning and improvement

The LHS Collaboratory's fall seminar series virtual kick-off event will showcase the LHS experiences of three research-intensive academic centers that have been promoting LHS methods. We will be joined by distinguished senior colleagues from Duke,Vanderbilt, and Washington University, who will describe and discuss their institutions' work in this area. They will discuss strategies employed, investments made, challenges encountered, and successes achieved.

Panelists:
Kevin B. Johnson, MD, MS, FAAP, FACMI, Vanderbilt University
Christopher J. Lindsell, PhD, Vanderbilt University
Philip Payne, PhD, FACMI, Washington University
Michael Pencina, PhD, Duke University
Eric G. Poon, MD, MPH, Duke University

Discussant:
Carol R. Bradford, MD, MS, Executive Vice Dean for Academic Affairs, University of Michigan Medical School, Chief Academic Officer, Michigan Medicine, Professor of Otolaryngology-Head and Neck Surgery

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Lecture / Discussion Thu, 20 Aug 2020 09:45:31 -0400 2020-09-17T09:00:00-04:00 2020-09-17T11:00:00-04:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion LHS Collaboratory Logo-blocks
DCMB / CCMB Weekly Virtual Seminar featuring Gioele La Manno, Ph.D. (EPFL Life Sciences Early Independent Research Scholar (ELISIR) (September 18, 2020 12:00pm) https://events.umich.edu/event/77057 77057-19836073@events.umich.edu Event Begins: Friday, September 18, 2020 12:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

I will present our comprehensive single-cell transcriptome atlas of mouse brain development spanning from gastrulation to birth. In this atlasing effort, we identified almost a thousand distinct cellular states, including the initial emergence of the neuroepithelium, different glioblasts, and a rich set of region-specific secondary organizers that we localize spatially. In this context, I will provide an example of how the spatially-resolved transcriptomic data can be particularly useful to interpret the complexity of such complex atlases.

Continuing in this direction, I will show the approach that we recently proposed as a general way to spatially resolve different types of next-generation sequencing data. We designed an imaging-free framework to localize high throughput readouts within a tissue by combining compressive sampling and image reconstruction. Our first implementation of this framework transformed a low-input RNA sequencing protocol into an imaging-free spatial transcriptomics technique (STRP-seq).

Finally, I will showcase the technique with the profiling of the brain of the Australian bearded dragon Pogona vitticeps. With this analysis, we revealed the molecular anatomy of the telencephalon of this lizard and provided evidence for a marked regionalization of the reptilian pallium and subpallium.

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Lecture / Discussion Wed, 16 Sep 2020 11:27:53 -0400 2020-09-18T12:00:00-04:00 2020-09-18T13:00:00-04:00 Off Campus Location DCMB Seminar Series Lecture / Discussion Gioele La Manno, Ph.D. (EPFL Life Sciences Early Independent Research Scholar (ELISIR) École polytechnique fédérale de Lausanne ‐ EPFL Swiss Federal Institute of Technology Lausanne)
FIRST Mass Meeting (September 20, 2020 6:00pm) https://events.umich.edu/event/76584 76584-19871824@events.umich.edu Event Begins: Sunday, September 20, 2020 6:00pm
Location:
Organized By: Futures in Research, Science, Teaching - FIRST

FIRST is a group of undergrads, grad students, and postdocs in the sciences. The goal of our org is to prepare undergrads for the grad school application process and research at the graduate level.

FIRST Sign-Up: https://forms.gle/bDBuue63ZhbtZvpg9

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Rally / Mass Meeting Sun, 20 Sep 2020 18:11:50 -0400 2020-09-20T18:00:00-04:00 2020-09-20T18:30:00-04:00 Futures in Research, Science, Teaching - FIRST Rally / Mass Meeting FIRST Logo
RNA Seminar featuring: Andrey Krasilnikov, Penn State (September 21, 2020 4:00pm) https://events.umich.edu/event/75802 75802-19608017@events.umich.edu Event Begins: Monday, September 21, 2020 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

ZOOM REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_obckKUCLT4mXI7kPskzc-Q

KEYWORDS: Ribozymes, RNase P, RNase MRP, ribonucleoprotein complexes, RNA-driven protein remodelling

ABSTRACT: Ribonuclease (RNase) P is a ribozyme-based catalytic ribonucleoprotein complex involved primarily in the maturation of tRNA in all three domains of life. In the course of evolution, the size and complexity of RNase P grew as the catalytic RNA moiety recruited additional protein components. In eukaryotes, the RNase P lineage has split, giving rise to a related RNP enzyme called RNase MRP, which shares multiple structural features (including most of the protein components) with the eukaryotic RNase P, but has a distinct and non-overlapping specificity. We report the recently solved cryo-EM structure of the 450 kDa yeast RNase MRP holoenzyme and compare it with the structure of its progenitor RNP, RNase P. We show that, surprisingly, several of the proteins shared by RNase MRP and RNase P undergo RNA-driven structural remodeling, allowing the same proteins to function in distinct structural contexts. This remodeling, combined with altered peripheral RNA elements, results in the functional diversification of the two closely related RNPs, in spite of the structural conservation of the nearly identical catalytic cores, demonstrating structural underpinnings of the acquisition of new functions by catalytic RNPs.

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Lecture / Discussion Thu, 17 Sep 2020 07:12:03 -0400 2020-09-21T16:00:00-04:00 2020-09-21T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Andrey Krasilnikov, Penn State
Tips to Tame Stress: Lessons from Plant Endomembranes- Department of Biological Chemistry Seminar (September 22, 2020 12:00pm) https://events.umich.edu/event/76178 76178-19671610@events.umich.edu Event Begins: Tuesday, September 22, 2020 12:00pm
Location: Off Campus Location
Organized By: Biological Chemistry

Dr. Federica Brandizzi will give the Department of Biological Chemistry virtual seminar on Tuesday September 22nd, 2020. You must have a University of Michigan email address to join the webinar.

Virtual Seminar: https://umich-health.zoom.us/j/91254715072

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Workshop / Seminar Wed, 26 Aug 2020 12:42:55 -0400 2020-09-22T12:00:00-04:00 2020-09-22T13:00:00-04:00 Off Campus Location Biological Chemistry Workshop / Seminar Brandizzi
Modern approaches to revisit unsolved mysteries of the spermatogenesis program. (September 23, 2020 9:30am) https://events.umich.edu/event/77005 77005-19790534@events.umich.edu Event Begins: Wednesday, September 23, 2020 9:30am
Location: Off Campus Location
Organized By: Cell & Developmental Biology

We are pleased to welcome Sue Hammoud, Ph.D., Assistant Professor of Human Genetics and Assistant Professor of Obstetrics and Gynecology, to the 2020 Cell & Developmental Biology Zoom conference on Wednesday, September 23, 2020.

Hosted by: Doug Engel

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Lecture / Discussion Thu, 10 Sep 2020 12:30:58 -0400 2020-09-23T09:30:00-04:00 2020-09-23T10:30:00-04:00 Off Campus Location Cell & Developmental Biology Lecture / Discussion Sue Hammoud, Ph.D., Assistant Professor of Human Genetics and Assistant Professor of Obstetrics and Gynecology