Happening @ Michigan https://events.umich.edu/list/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. Ph.D. Defense: Cameron M. Louttit (August 22, 2019 10:00am) https://events.umich.edu/event/65528 65528-16611701@events.umich.edu Event Begins: Thursday, August 22, 2019 10:00am
Location: Lurie Robert H. Engin. Ctr
Organized By: Biomedical Engineering

Department of Biomedical Engineering Final Oral Examination

Cameron M. Louttit

In Vitro Platforms for the Study and Manipulation of Neutrophil Extracellular Traps

Though only recently discovered, neutrophil extracellular traps (NETs) have rapidly attracted scientific and clinical interest as a potent weapon in the arsenal of innate immunity. These structures, fibers of decondensed nuclear material on which neutrophils localize their vast antimicrobial and proinflammatory stores, are released into sites of inflammation or injury with the presumed aim of constraining and clearing bacteria. It has also been shown, however, that NETs cause substantial harm, contributing to the pathogeneses of autoimmune diseases, cancers, and thrombotic disorders as well as inciting non-specific inflammation and collateral host damage. Thus, NETs as currently understood represent a paradox in which protection seems to be outweighed by detriment. In this light, fundamental questions have arisen surrounding the identity, function, and utility of NETs in vivo. This work describes two novel platforms rationally designed to assist in understanding and contextualizing this paradox.

In the first approach, aimed at better understanding NET identity, a reductionist in vitro assay framework was iteratively developed to study NETs from the bottom up, beginning first with their DNA-histone fibrous substructure. Precise control of DNA-histone complexation yielded a robust, reproducible, and scalable structure that stood in stark contrast to low-yield and heterogeneous NET preparations. These structures, termed DNA-histone mesostructures (DHMs), mirrored both NET morphology and, to an extent, function. In doing so, DHMs provided a novel assay platform which elucidated the significant role of the isolated NET backbone in common NET-associated phenomena, such as bacterial trapping and immune activation. In addition, it permitted the confirmation and quantification of the role of the peptide LL-37 in altering NET degradation behavior. Beyond these structural studies, DHMs also yielded novel cell-based assays, including efforts to characterize the interaction between NET components and the immune system. Such studies elucidated the key role of DNA-histone synergism in NET-mediated immunostimulation, particularly amplified by the structural inclusion of non-methylated DNA. Additionally, they highlighted the importance of cell-structure proximity and contact in immune cell uptake and activation.

In the second approach, aimed at addressing the perceived pathophysiological imbalance mediated by NETs, a nanoparticulate platform was leveraged to modify cell-derived NETs in vitro with the aim of ultimately modifying them in situ. The chosen nanoparticles, hollow nanocapsules composed of polysaccharide, were internalized into neutrophils but avoided immediate NET induction; instead, they primed neutrophils for enhanced NET production only after classical stimulation. Importantly, the NETs produced by nanocapsule-loaded neutrophils were interwoven with these particles, thereby indicating significant promise for future therapeutic modification of these structures.

Though distinct in motivation and design, these two platforms demonstrate novel approaches to understanding NETs and have revealed substantial insights about both NET identity and utility as described in this work. For both, the simultaneous youth and breadth of the NET field provide a profoundly large and diverse application base. Further studies leveraging both NET-mimicking in vitro assay platforms and NET-binding nanoparticles will therefore continue to assist in the determination of both foundational and therapeutic NET biology.

Date: Thursday, August 22, 2019
Time: 10:00 AM
Location: General Motors Conference Room, Lurie Engineering Center
Chair: Dr. James Moon

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Lecture / Discussion Wed, 21 Aug 2019 09:05:06 -0400 2019-08-22T10:00:00-04:00 2019-08-22T11:00:00-04:00 Lurie Robert H. Engin. Ctr Biomedical Engineering Lecture / Discussion BME Event
Application of Big Data in Medicine - Experience in China (August 22, 2019 12:00pm) https://events.umich.edu/event/65206 65206-16547477@events.umich.edu Event Begins: Thursday, August 22, 2019 12:00pm
Location: Taubman Library
Organized By: DCMB Seminar Series

Abstract
During the last few years, substantial enthusiasm has emerged towards the application of big data in medicine in China, in the expectation of resolving many existing challenges by combining powerful data resources with novel technologies. In the present talk, the data eco-system, status of current practice, existing challenges in the area will be discussed. In addition, the activities of National Institute of Health Data Science at Peking University will be briefly introduced.

Luxia Zhang, MD, MPH
Dr. Luxia Zhang is the professor in the renal division of Peking University First Hospital, and the Assistant Dean of National Institute of Health Data Science at Peking University. She obtained her M.D. degree at Peking University; and her MPH degree at Harvard School of Public Health.
Her research has focused on prevalence, risk factors, intervention and management of kidney disease in China. Her work provides first-hand information of kidney disease in China, and has gained wide attention internationally. During the last 3 years, she has initiated several projects based on big data and utilizing machine learning in the field of major non-communicable chronic diseases. Her studies have been published in top medical journals including the N Engl J Med, Lancet and BMJ. She was given 2016 Young Investigator Award by the Chinese Society of Nephrology. She is now the vice president of Beijing Young Nephrologists Society, and the editor of American Journal of Kidney Diseases.

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Lecture / Discussion Tue, 13 Aug 2019 11:38:17 -0400 2019-08-22T12:00:00-04:00 2019-08-22T14:00:00-04:00 Taubman Library DCMB Seminar Series Lecture / Discussion
Science Forum Demo: Counting Cells (August 24, 2019 11:00am) https://events.umich.edu/event/63860 63860-16209984@events.umich.edu Event Begins: Saturday, August 24, 2019 11:00am
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world around you in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

The human body is made of more than 37 trillion cells. Most of them need to be replaced every couple of months, weeks, or sometimes in the course of only a few days. Our cells grow and divide constantly to get this massive job done. But how do cells replicate themselves? How do things move in, out, and around the cell, and into new cells? Join us as we explore how our bodies carry out this massive process. We will learn about cell structure and division and observe cells up-close and in action!
Funded by the National Science Foundation.

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Presentation Mon, 05 Aug 2019 09:35:06 -0400 2019-08-24T11:00:00-04:00 2019-08-24T11:20:00-04:00 Biological Sciences Building Museum of Natural History Presentation Biological Sciences Building
Science Forum Demo: Cow’s Eye Dissection (August 24, 2019 3:00pm) https://events.umich.edu/event/63449 63449-16209993@events.umich.edu Event Begins: Saturday, August 24, 2019 3:00pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world around you in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

Have you ever wondered what makes our eyes work or how we see? We’ll dissect a cow’s eye to take a closer look at the organ that helps us see the world. How is it similar to and different from our eyes, and those of other animals? Learn the parts of the eye and how they work together to illuminate our sight.

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Lecture / Discussion Thu, 15 Aug 2019 07:26:46 -0400 2019-08-24T15:00:00-04:00 2019-08-24T15:20:00-04:00 Biological Sciences Building Museum of Natural History Lecture / Discussion UMMNH Science Forum
Biodiversity Lab Chat (August 24, 2019 3:30pm) https://events.umich.edu/event/62767 62767-16210011@events.umich.edu Event Begins: Saturday, August 24, 2019 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the website or Welcome Desk for times.

Join an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world. All ages welcome.

Wednesdays, 11 a.m.
Saturdays and Sundays, 3:30 pm.

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Other Mon, 05 Aug 2019 09:46:09 -0400 2019-08-24T15:30:00-04:00 2019-08-24T15:45:00-04:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
Science Forum Demo: Counting Cells (August 25, 2019 11:00am) https://events.umich.edu/event/63860 63860-16209989@events.umich.edu Event Begins: Sunday, August 25, 2019 11:00am
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world around you in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

The human body is made of more than 37 trillion cells. Most of them need to be replaced every couple of months, weeks, or sometimes in the course of only a few days. Our cells grow and divide constantly to get this massive job done. But how do cells replicate themselves? How do things move in, out, and around the cell, and into new cells? Join us as we explore how our bodies carry out this massive process. We will learn about cell structure and division and observe cells up-close and in action!
Funded by the National Science Foundation.

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Presentation Mon, 05 Aug 2019 09:35:06 -0400 2019-08-25T11:00:00-04:00 2019-08-25T11:20:00-04:00 Biological Sciences Building Museum of Natural History Presentation Biological Sciences Building
Science Forum Demo: Cow’s Eye Dissection (August 25, 2019 3:00pm) https://events.umich.edu/event/63449 63449-16209998@events.umich.edu Event Begins: Sunday, August 25, 2019 3:00pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world around you in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

Have you ever wondered what makes our eyes work or how we see? We’ll dissect a cow’s eye to take a closer look at the organ that helps us see the world. How is it similar to and different from our eyes, and those of other animals? Learn the parts of the eye and how they work together to illuminate our sight.

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Lecture / Discussion Thu, 15 Aug 2019 07:26:46 -0400 2019-08-25T15:00:00-04:00 2019-08-25T15:20:00-04:00 Biological Sciences Building Museum of Natural History Lecture / Discussion UMMNH Science Forum
Biodiversity Lab Chat (August 25, 2019 3:30pm) https://events.umich.edu/event/62767 62767-16210016@events.umich.edu Event Begins: Sunday, August 25, 2019 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the website or Welcome Desk for times.

Join an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world. All ages welcome.

Wednesdays, 11 a.m.
Saturdays and Sundays, 3:30 pm.

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Other Mon, 05 Aug 2019 09:46:09 -0400 2019-08-25T15:30:00-04:00 2019-08-25T15:45:00-04:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
EEB Tuesday Seminars resume Sept. 3 (August 27, 2019 12:00pm) https://events.umich.edu/event/64502 64502-16378894@events.umich.edu Event Begins: Tuesday, August 27, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

See you soon!

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Workshop / Seminar Wed, 14 Aug 2019 10:49:11 -0400 2019-08-27T12:00:00-04:00 2019-08-27T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Biological Sciences Building background, UM EEB logo and text reading EEB Tuesday Lunch Seminars
Science Forum Demo: Counting Cells (August 31, 2019 11:00am) https://events.umich.edu/event/63860 63860-16209985@events.umich.edu Event Begins: Saturday, August 31, 2019 11:00am
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world around you in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

The human body is made of more than 37 trillion cells. Most of them need to be replaced every couple of months, weeks, or sometimes in the course of only a few days. Our cells grow and divide constantly to get this massive job done. But how do cells replicate themselves? How do things move in, out, and around the cell, and into new cells? Join us as we explore how our bodies carry out this massive process. We will learn about cell structure and division and observe cells up-close and in action!
Funded by the National Science Foundation.

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Presentation Mon, 05 Aug 2019 09:35:06 -0400 2019-08-31T11:00:00-04:00 2019-08-31T11:20:00-04:00 Biological Sciences Building Museum of Natural History Presentation Biological Sciences Building
Science Forum Demo: Cow’s Eye Dissection (August 31, 2019 3:00pm) https://events.umich.edu/event/63449 63449-16209994@events.umich.edu Event Begins: Saturday, August 31, 2019 3:00pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world around you in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

Have you ever wondered what makes our eyes work or how we see? We’ll dissect a cow’s eye to take a closer look at the organ that helps us see the world. How is it similar to and different from our eyes, and those of other animals? Learn the parts of the eye and how they work together to illuminate our sight.

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Lecture / Discussion Thu, 15 Aug 2019 07:26:46 -0400 2019-08-31T15:00:00-04:00 2019-08-31T15:20:00-04:00 Biological Sciences Building Museum of Natural History Lecture / Discussion UMMNH Science Forum
Biodiversity Lab Chat (August 31, 2019 3:30pm) https://events.umich.edu/event/62767 62767-16210012@events.umich.edu Event Begins: Saturday, August 31, 2019 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the website or Welcome Desk for times.

Join an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world. All ages welcome.

Wednesdays, 11 a.m.
Saturdays and Sundays, 3:30 pm.

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Other Mon, 05 Aug 2019 09:46:09 -0400 2019-08-31T15:30:00-04:00 2019-08-31T15:45:00-04:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
Science Forum Demo: Counting Cells (September 1, 2019 11:00am) https://events.umich.edu/event/63860 63860-16482917@events.umich.edu Event Begins: Sunday, September 1, 2019 11:00am
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world around you in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

The human body is made of more than 37 trillion cells. Most of them need to be replaced every couple of months, weeks, or sometimes in the course of only a few days. Our cells grow and divide constantly to get this massive job done. But how do cells replicate themselves? How do things move in, out, and around the cell, and into new cells? Join us as we explore how our bodies carry out this massive process. We will learn about cell structure and division and observe cells up-close and in action!
Funded by the National Science Foundation.

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Presentation Mon, 05 Aug 2019 09:35:06 -0400 2019-09-01T11:00:00-04:00 2019-09-01T11:20:00-04:00 Biological Sciences Building Museum of Natural History Presentation Biological Sciences Building
Science Forum Demo: Cow’s Eye Dissection (September 1, 2019 3:00pm) https://events.umich.edu/event/63449 63449-16563480@events.umich.edu Event Begins: Sunday, September 1, 2019 3:00pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world around you in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

Have you ever wondered what makes our eyes work or how we see? We’ll dissect a cow’s eye to take a closer look at the organ that helps us see the world. How is it similar to and different from our eyes, and those of other animals? Learn the parts of the eye and how they work together to illuminate our sight.

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Lecture / Discussion Thu, 15 Aug 2019 07:26:46 -0400 2019-09-01T15:00:00-04:00 2019-09-01T15:20:00-04:00 Biological Sciences Building Museum of Natural History Lecture / Discussion UMMNH Science Forum
Biodiversity Lab Chat (September 1, 2019 3:30pm) https://events.umich.edu/event/62767 62767-16482957@events.umich.edu Event Begins: Sunday, September 1, 2019 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the website or Welcome Desk for times.

Join an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world. All ages welcome.

Wednesdays, 11 a.m.
Saturdays and Sundays, 3:30 pm.

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Other Mon, 05 Aug 2019 09:46:09 -0400 2019-09-01T15:30:00-04:00 2019-09-01T16:00:00-04:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
EEB Tuesday Lunch Seminar: Studying speciation in terrestrial gastropods: integrating genomic, ecological, and morphological data (September 3, 2019 12:00pm) https://events.umich.edu/event/65222 65222-16555450@events.umich.edu Event Begins: Tuesday, September 3, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Speciation is of fundamental interest to evolutionary biologists, and is driven by a complex interplay of factors. By integrating genomic, ecological, and morphological data, we can begin to disentangle the process of speciation. The Pacific Northwest of North America has a rich history of phylogeographic research, and temperate rainforest endemics from the region have been influenced by a diverse array of factors, including climatic and geologic events. By studying groups from this region in a comparative context, we identify ecological and morphological traits influencing species responses to these events. Further, by studying speciation and species limits in an integrative context, we can begin to understand how these and other factors have contributed to speciation. We focus on terrestrial taildropper slugs (Genus Prophysaon), and infer a history of divergence followed by secondary contact, with ecological data suggesting that reinforcement may have driven speciation. By integrating across datatypes and considering the processes that drive speciation, we infer biologically meaningful species limits and learn about which factors led to speciation.

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Workshop / Seminar Tue, 03 Sep 2019 13:03:54 -0400 2019-09-03T12:00:00-04:00 2019-09-03T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar A brown slug on a green leaf, its body curved into an S shape
Biodiversity Lab Chat (September 4, 2019 11:00am) https://events.umich.edu/event/62767 62767-16482949@events.umich.edu Event Begins: Wednesday, September 4, 2019 11:00am
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the website or Welcome Desk for times.

Join an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world. All ages welcome.

Wednesdays, 11 a.m.
Saturdays and Sundays, 3:30 pm.

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Other Mon, 05 Aug 2019 09:46:09 -0400 2019-09-04T11:00:00-04:00 2019-09-04T11:30:00-04:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
Science Forum Demo: Counting Cells (September 7, 2019 11:00am) https://events.umich.edu/event/63860 63860-16482913@events.umich.edu Event Begins: Saturday, September 7, 2019 11:00am
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world around you in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

The human body is made of more than 37 trillion cells. Most of them need to be replaced every couple of months, weeks, or sometimes in the course of only a few days. Our cells grow and divide constantly to get this massive job done. But how do cells replicate themselves? How do things move in, out, and around the cell, and into new cells? Join us as we explore how our bodies carry out this massive process. We will learn about cell structure and division and observe cells up-close and in action!
Funded by the National Science Foundation.

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Presentation Mon, 05 Aug 2019 09:35:06 -0400 2019-09-07T11:00:00-04:00 2019-09-07T11:20:00-04:00 Biological Sciences Building Museum of Natural History Presentation Biological Sciences Building
Biodiversity Lab Chat (September 7, 2019 3:30pm) https://events.umich.edu/event/62767 62767-16482953@events.umich.edu Event Begins: Saturday, September 7, 2019 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the website or Welcome Desk for times.

Join an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world. All ages welcome.

Wednesdays, 11 a.m.
Saturdays and Sundays, 3:30 pm.

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Other Mon, 05 Aug 2019 09:46:09 -0400 2019-09-07T15:30:00-04:00 2019-09-07T16:00:00-04:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
Science Forum Demo: Counting Cells (September 8, 2019 11:00am) https://events.umich.edu/event/63860 63860-16482918@events.umich.edu Event Begins: Sunday, September 8, 2019 11:00am
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world around you in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

The human body is made of more than 37 trillion cells. Most of them need to be replaced every couple of months, weeks, or sometimes in the course of only a few days. Our cells grow and divide constantly to get this massive job done. But how do cells replicate themselves? How do things move in, out, and around the cell, and into new cells? Join us as we explore how our bodies carry out this massive process. We will learn about cell structure and division and observe cells up-close and in action!
Funded by the National Science Foundation.

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Presentation Mon, 05 Aug 2019 09:35:06 -0400 2019-09-08T11:00:00-04:00 2019-09-08T11:20:00-04:00 Biological Sciences Building Museum of Natural History Presentation Biological Sciences Building
Biodiversity Lab Chat (September 8, 2019 3:30pm) https://events.umich.edu/event/62767 62767-16482958@events.umich.edu Event Begins: Sunday, September 8, 2019 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the website or Welcome Desk for times.

Join an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world. All ages welcome.

Wednesdays, 11 a.m.
Saturdays and Sundays, 3:30 pm.

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Other Mon, 05 Aug 2019 09:46:09 -0400 2019-09-08T15:30:00-04:00 2019-09-08T16:00:00-04:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
RNA innovation Seminar (September 9, 2019 4:00pm) https://events.umich.edu/event/65134 65134-16539445@events.umich.edu Event Begins: Monday, September 9, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Abstract: RNA regulation permeates neurobiology. Nociceptors are sensory neurons tasked with the detection of pain producing stimuli. Persistent changes in their activity, termed plasticity, benefit survival through injury avoidance. Nociceptors rely on cap-dependent translation to rapidly increase protein synthesis in response to pro-inflammatory signals. Comparatively little is known regarding the role of the regulatory factors bound to the 3' end of mRNA in nociceptor sensitization. Poly(A)-binding protein (PABP) stimulates translation initiation by bridging the Poly(A) tail to the eukaryotic initiation factor 4F complex associated with the mRNA cap. We have developed an RNA-based competitive inhibitor of PABP that attenuates behavioral responses to pain in mice. To identify the Poly(A) mRNAs subject to privileged translation in response to noxious cues, we have applied ribosome profiling to primary sensory neurons and tissues. A small number of transcripts are selectively translated in response to plasticity mediators. Among them is the capsid forming protein Arc. Arc has been implicated in synaptic plasticity and learning in the brain. We demonstrate that the ribosomal S6 kinase 1 is responsible for Arc production in nociceptors and describe a new role for local translation of Arc in afferent fibers. Collectively, our findings uncover mechanisms and targets of RNA control in sensory neurons that can be exploited to disrupt pain signaling.

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Lecture / Discussion Tue, 20 Aug 2019 15:48:42 -0400 2019-09-09T16:00:00-04:00 2019-09-09T17:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion flyer
EEB Tuesday Lunch Seminar: Towards a molecular model of monarch migration (September 10, 2019 12:00pm) https://events.umich.edu/event/64992 64992-16499301@events.umich.edu Event Begins: Tuesday, September 10, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Join us for our weekly brown bag lunch seminar.

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Workshop / Seminar Mon, 09 Sep 2019 12:20:54 -0400 2019-09-10T12:00:00-04:00 2019-09-10T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Monarch butterfly on a leaf
Environmental Research Seminar "Health & Household-Related Benefits of Weatherizing Low-Income Homes & Affordable Multifamily Buildings" (September 10, 2019 12:00pm) https://events.umich.edu/event/65290 65290-16565509@events.umich.edu Event Begins: Tuesday, September 10, 2019 12:00pm
Location: Public Health I (Vaughan Building)
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

The federal government, states, and utilities administer programs to improve the energy efficiency of low-income homes and affordable multifamily buildings. Investments in measures to save energy, as simple as air sealing and insulation, can also yield a broad range of non-energy benefits. This presentation will present research results that show that weatherization can improve health, home conditions, and social determinants of health. The results are drawn from three separate studies that were conducted nationally, regionally (Midwest and Northeast), and in Knoxville, Tennessee. Three3, Inc. conducts research and educational programming to promote the integration of environmental, social, and economic sustainability. The organization particularly focuses on fostering sustainable futures that: provide equitable benefits to low-income and disadvantaged populations (intra-generational equity); meets ethical obligations to future generations (inter-generational equity); and makes best use of the convergence of human knowledge and technology to meet sustainability goals.

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Workshop / Seminar Thu, 15 Aug 2019 15:56:22 -0400 2019-09-10T12:00:00-04:00 2019-09-10T13:00:00-04:00 Public Health I (Vaughan Building) Michigan Lifestage Environmental Exposures and Disease Center Workshop / Seminar 09/10/2019 Bruce Tonn "Health & Household-Related Benefits of Weatherizing Low-Income Homes & Affordable Multifamily Buildings"
Stem Cell Development: Stories of Two Niches. (September 10, 2019 4:00pm) https://events.umich.edu/event/65613 65613-16621819@events.umich.edu Event Begins: Tuesday, September 10, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for Cell Plasticity and Organ Design

2019-2020 Center for Organogenesis Seminar Series

Faculty Host: Peter Ma
For additional information contact: organogenesis@umich.edu

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Lecture / Discussion Thu, 22 Aug 2019 14:20:45 -0400 2019-09-10T16:00:00-04:00 2019-09-10T17:00:00-04:00 Taubman Biomedical Science Research Building Center for Cell Plasticity and Organ Design Lecture / Discussion Stem Cell Development: Stories of Two Niches.
Biodiversity Lab Chat (September 11, 2019 11:00am) https://events.umich.edu/event/62767 62767-16482950@events.umich.edu Event Begins: Wednesday, September 11, 2019 11:00am
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the website or Welcome Desk for times.

Join an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world. All ages welcome.

Wednesdays, 11 a.m.
Saturdays and Sundays, 3:30 pm.

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Other Mon, 05 Aug 2019 09:46:09 -0400 2019-09-11T11:00:00-04:00 2019-09-11T11:30:00-04:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
DCMB Seminar - Neurons in pathology through the lens of multi-omics and data analytics (September 11, 2019 4:00pm) https://events.umich.edu/event/65485 65485-16605630@events.umich.edu Event Begins: Wednesday, September 11, 2019 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract:

Advances in stem cell engineering, omics technologies and data sciences offer a unique scope for deciphering the myriad ways molecular circuits dysfunction in pathologies of the brain. Recently, we have developed and explored iPSC-derived neurons from familial Alzheimer’s disease patients using a systems-level, multi-omics approach, identifying disease-related endotypes, which are commonly dysregulated in patient-derived neurons and patient brain tissue alike. By integrating RNA-Seq, ATAC-Seq, and ChIP-Seq approaches, we determined that the defining disease-causing mechanism of AD is de-differentiation of neurons, driven primarily through the REST-mediated repression of neuronal lineage specification gene programs and the activation of cell cycle reentry and non-specific germ layer precursor gene programs concomitant with modifications in chromatin accessibility. Strikingly, our reanalysis of previously-generated AD-patient brain tissue showed similar enrichment of neuronal repression and de-differentiation mechanisms. Surprisingly, our earlier work on glioblastoma also showed de-differentiation and initiation of some of the shared diseased endotypes as common features. We postulate that de-differentiation and reprogramming are hallmark mechanisms of numerous pathologies, arguably genetically evolved to serve as protection mechanisms.

Acknowledgements: This work was done in collaboration with the Laboratory of Dr. Wagner and his colleagues.

References:
Caldwell AB, Liu Q, Schroth GP, Tanzi RE, Galasko DR, Yuan SH, Wagner SL, Subramaniam S. Dedifferentiation orchestrated through remodeling of the chromatin landscape defines PSEN1 mutation-induced Alzheimer's Disease. 2019 (under revision in Nature) Available from: https://www.biorxiv.org/content/10.1101/531202v1.
Friedmann-Morvinski D, Bhargava V, Gupta S, Verma IM, Subramaniam S. Identification of therapeutic targets for glioblastoma by network analysis. Oncogene. 2016;35(5):608-20. PMCID: 4641815.
Bhargava V, Ko P, Willems E, Mercola M, Subramaniam S. Quantitative transcriptomics using designed primer-based amplification. Sci Rep. 2013;3:1740. PMCID: 3638165.

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Lecture / Discussion Tue, 20 Aug 2019 13:49:51 -0400 2019-09-11T16:00:00-04:00 2019-09-11T17:00:00-04:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
Growth and Grit: Developing a Mindset for Success (September 11, 2019 5:30pm) https://events.umich.edu/event/65979 65979-16678382@events.umich.edu Event Begins: Wednesday, September 11, 2019 5:30pm
Location: Angell Hall
Organized By: Science Learning Center

What if your ability to succeed in your classes was determined in part before you even stepped into the classroom? What is the one quality you need to overcome adversity academically and in life? This workshop will detail the research of Dr. Carol Dweck and her groundbreaking work on the concept of mindset. Students will learn how to abandon a debilitating fixed mindset in favor of a growth mindset, leading to success in areas they once considered too difficult. The workshop will also introduce students to the research of Dr. Angela Duckworth, and how a growth mindset can lead to the development of grit, an essential characteristic to overcoming our fear of failure.

Registration Link: http://ttc.iss.lsa.umich.edu/undergrad/sessions/growth-and-grit-developing-a-mindset-for-success-science-success-series/

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Workshop / Seminar Thu, 09 Jan 2020 13:40:53 -0500 2019-09-11T17:30:00-04:00 2019-09-11T19:00:00-04:00 Angell Hall Science Learning Center Workshop / Seminar
Robotics Interfaces with Biology (September 12, 2019 4:00pm) https://events.umich.edu/event/65462 65462-16603589@events.umich.edu Event Begins: Thursday, September 12, 2019 4:00pm
Location: Biological Sciences Building
Organized By: Michigan Robotics

Gail Patricelli, Professor & Chancellor’s Fellow, Department of Evolution and Ecology, UC Davis presents her work on using robotics to study courtship behavior in birds.

Males in many species must convince females to mate by producing elaborate courtship displays tuned to female preferences, like the song of a cricket or the train of a peacock. But courtship in many species is more like a negotiation than an advertisement, thus in addition to elaborate signals, success in courtship may require tactical skills. These skills may include the ability to choose a flattering display site, respond appropriately to female courtship signals, and adjust display investment in response to the marketplace of other males and females. My lab has been investigating courtship negotiations in greater sage-grouse, which mate in an open marketplace of competing males and choosing females (the lek). I will discuss experiments using robotic females to investigate courtship interactions between the sexes. I will also discuss ongoing research investigating how off-lek foraging behaviors affect on-lek displays, and how this basic science has informed my lab's research into human impacts on lekking activities.

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Workshop / Seminar Tue, 20 Aug 2019 09:15:09 -0400 2019-09-12T16:00:00-04:00 2019-09-12T17:00:00-04:00 Biological Sciences Building Michigan Robotics Workshop / Seminar Sage grouse photo by Gail Patricelli
MCDB Seminar: Estrogen Regulation of Gene Expression in the Brain (September 13, 2019 12:00pm) https://events.umich.edu/event/64084 64084-16115268@events.umich.edu Event Begins: Friday, September 13, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Josie Clowney

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Workshop / Seminar Tue, 10 Sep 2019 12:38:29 -0400 2019-09-13T12:00:00-04:00 2019-09-13T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar micrograph of brain, stained green with chart of estrogen measurement and others
Science Forum Demo: Counting Cells (September 14, 2019 11:00am) https://events.umich.edu/event/63860 63860-16482914@events.umich.edu Event Begins: Saturday, September 14, 2019 11:00am
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world around you in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

The human body is made of more than 37 trillion cells. Most of them need to be replaced every couple of months, weeks, or sometimes in the course of only a few days. Our cells grow and divide constantly to get this massive job done. But how do cells replicate themselves? How do things move in, out, and around the cell, and into new cells? Join us as we explore how our bodies carry out this massive process. We will learn about cell structure and division and observe cells up-close and in action!
Funded by the National Science Foundation.

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Presentation Mon, 05 Aug 2019 09:35:06 -0400 2019-09-14T11:00:00-04:00 2019-09-14T11:20:00-04:00 Biological Sciences Building Museum of Natural History Presentation Biological Sciences Building
Biodiversity Lab Chat (September 14, 2019 3:30pm) https://events.umich.edu/event/62767 62767-16482954@events.umich.edu Event Begins: Saturday, September 14, 2019 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the website or Welcome Desk for times.

Join an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world. All ages welcome.

Wednesdays, 11 a.m.
Saturdays and Sundays, 3:30 pm.

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Other Mon, 05 Aug 2019 09:46:09 -0400 2019-09-14T15:30:00-04:00 2019-09-14T16:00:00-04:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
Science Forum Demo: Counting Cells (September 15, 2019 11:00am) https://events.umich.edu/event/63860 63860-16482919@events.umich.edu Event Begins: Sunday, September 15, 2019 11:00am
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world around you in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

The human body is made of more than 37 trillion cells. Most of them need to be replaced every couple of months, weeks, or sometimes in the course of only a few days. Our cells grow and divide constantly to get this massive job done. But how do cells replicate themselves? How do things move in, out, and around the cell, and into new cells? Join us as we explore how our bodies carry out this massive process. We will learn about cell structure and division and observe cells up-close and in action!
Funded by the National Science Foundation.

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Presentation Mon, 05 Aug 2019 09:35:06 -0400 2019-09-15T11:00:00-04:00 2019-09-15T11:20:00-04:00 Biological Sciences Building Museum of Natural History Presentation Biological Sciences Building
Biodiversity Lab Chat (September 15, 2019 3:30pm) https://events.umich.edu/event/62767 62767-16482959@events.umich.edu Event Begins: Sunday, September 15, 2019 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the website or Welcome Desk for times.

Join an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world. All ages welcome.

Wednesdays, 11 a.m.
Saturdays and Sundays, 3:30 pm.

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Other Mon, 05 Aug 2019 09:46:09 -0400 2019-09-15T15:30:00-04:00 2019-09-15T16:00:00-04:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
EEB Tuesday Lunch Seminar: Complex forms of spatial patterning: self-organization from ecological complexity (September 17, 2019 12:00pm) https://events.umich.edu/event/64995 64995-16501294@events.umich.edu Event Begins: Tuesday, September 17, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Please join us at our weekly EEB brown bag lunch seminar.

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Workshop / Seminar Tue, 10 Sep 2019 11:20:02 -0400 2019-09-17T12:00:00-04:00 2019-09-17T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Extinction graph with images showing various members of the ecological community he studies. Text on graph includes: bifurcation and chaos zone, basin boundary collision, hysteresis zones, saddle/node bifurcation and extinction graph shows upward trend
Gene modified and edited cell based therapies for cancer: Are we there yet? (September 17, 2019 4:00pm) https://events.umich.edu/event/65612 65612-16621814@events.umich.edu Event Begins: Tuesday, September 17, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for Cell Plasticity and Organ Design

2019-2020 Centr for Organogenesis Seminar Series.

Faculty Host: Xing Fan

For additional information contact: organogenesis@umich.edu

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Lecture / Discussion Thu, 22 Aug 2019 14:11:42 -0400 2019-09-17T16:00:00-04:00 2019-09-17T17:00:00-04:00 Taubman Biomedical Science Research Building Center for Cell Plasticity and Organ Design Lecture / Discussion Gene modified and edited cell based therapies for cancer: Are we there yet?
Reconstituting Eukaryotic Cytokinesis (September 17, 2019 4:00pm) https://events.umich.edu/event/65873 65873-16662157@events.umich.edu Event Begins: Tuesday, September 17, 2019 4:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Hosts: Allen Liu (Mechanical Engineering), Ann Miller (MCDB), and Puck Ohi (CDB)

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Workshop / Seminar Tue, 27 Aug 2019 16:40:41 -0400 2019-09-17T16:00:00-04:00 2019-09-17T17:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar pombe cytokinesis
Violation of Mendel’s First Law: chromosome competition in meiosis (September 18, 2019 9:30am) https://events.umich.edu/event/65374 65374-16573573@events.umich.edu Event Begins: Wednesday, September 18, 2019 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

2019 Cell & Developmental Biology Seminar Series

Hosted By: Ajit Joglekar, PhD and Yukiko Yamashita, PhD

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Lecture / Discussion Fri, 16 Aug 2019 16:44:53 -0400 2019-09-18T09:30:00-04:00 2019-09-18T10:30:00-04:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion Michael Lampson
Biodiversity Lab Chat (September 18, 2019 11:00am) https://events.umich.edu/event/62767 62767-16482951@events.umich.edu Event Begins: Wednesday, September 18, 2019 11:00am
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the website or Welcome Desk for times.

Join an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world. All ages welcome.

Wednesdays, 11 a.m.
Saturdays and Sundays, 3:30 pm.

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Other Mon, 05 Aug 2019 09:46:09 -0400 2019-09-18T11:00:00-04:00 2019-09-18T11:30:00-04:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
Make It Stick: Research-Based Learning Strategies You Need to Know (September 18, 2019 5:30pm) https://events.umich.edu/event/65980 65980-16678383@events.umich.edu Event Begins: Wednesday, September 18, 2019 5:30pm
Location: Angell Hall
Organized By: Science Learning Center

The study and learning strategies students often bring to college are often insufficient to help them succeed at the university level. Particularly in challenging STEM courses, students can't simply memorize or cram their way to a good grade. This workshop will focus on the popular learning strategies to avoid, as well as the top three strategies you don't know but are shown by research to be the most effective for long-term learning.

Registration Link: http://ttc.iss.lsa.umich.edu/undergrad/sessions/make-it-stick-research-based-learning-strategies-you-need-to-know-science-success-series/

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Workshop / Seminar Wed, 04 Sep 2019 15:39:54 -0400 2019-09-18T17:30:00-04:00 2019-09-18T19:00:00-04:00 Angell Hall Science Learning Center Workshop / Seminar
Mary-Claire King, PhD [2019 MaryFran Sowers Memorial Lecture] (September 19, 2019 4:00pm) https://events.umich.edu/event/63376 63376-16161554@events.umich.edu Event Begins: Thursday, September 19, 2019 4:00pm
Location: Public Health II
Organized By: Center for Midlife Science

A pre-eminent scholar, Dr. King leads studies to understand the genetic causes of serious human disorders including breast and ovarian cancer and schizophrenia. Her work focuses on disentangling genetic heterogeneity in complex traits, and on discovering rare alleles that cause common disorders. From her ground-breaking doctoral dissertation that transformed evolutionary biology to her formative work proving the existence of a major gene for a complex trait that demonstrated the genetic inheritance of breast cancer, Dr. King has contributed significantly to the advancement of scientific knowledge of genetics. Most recently, her laboratory developed and patented a targeted capture and massively parallel sequencing approach (BROCA) that detects mutations in breast and ovarian cancer genes.

A leading human rights advocate, Dr. King pioneered the development of genomics tools for human rights investigations including use of mitochondrial DNA (mtDNA) sequencing to match kidnapped children to possible maternal relatives after the end of Argentinian dictatorship of 1975-1983. Her approach is now used by governmental and United Nations forensic teams worldwide to identify remains of victims of extra-judicial execution and missing soldiers.

Dr. King received her PhD in Genetics from the University of California at Berkeley, and her postdoctoral training at UC San Francisco. A professor at UC Berkeley from 1976-1995, she has been the American Cancer Society Professor of Medical Genetics and Genome Sciences at the University of Washington since 1995. She is a member of the National Academy of Medicine (1994), the American Academy of Arts and Sciences (1999), and the National Academy of Sciences (2005) and is a past President of the American Society of Human Genetics. Among her many honors, she was awarded the Lasker-Koshland Special Achievement Award in Medical Science (2014), the National Medal of Science (2016) and the Advocacy Award of the American Society of Human Genetics (2018).
A reception, sponsored by UM Precision Health, will immediately follow the lecture.

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Lecture / Discussion Mon, 16 Sep 2019 14:10:55 -0400 2019-09-19T16:00:00-04:00 2019-09-19T17:30:00-04:00 Public Health II Center for Midlife Science Lecture / Discussion Mary-Claire King, PhD
BUDS Mass Meeting (September 19, 2019 6:30pm) https://events.umich.edu/event/66427 66427-16736297@events.umich.edu Event Begins: Thursday, September 19, 2019 6:30pm
Location: Mason Hall
Organized By: Program in Biology

We are an undergraduate club called BUDS (Botany Undergrads Doing Stuff). Our group is pretty small right now, and we are hoping to expand. We are very interested in anything that is plant related. Some of the activities we do include volunteering at the Arboretum, planting small gardens, and visiting local farms. Our mass meeting is being held September 19. All are welcome, no prior plant knowledge necessary!

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Meeting Thu, 05 Sep 2019 12:12:42 -0400 2019-09-19T18:30:00-04:00 2019-09-19T19:30:00-04:00 Mason Hall Program in Biology Meeting BUDS Meeting Poster
MCDB Seminar: Developmental Origins of Neural Circuits in Drosophila (September 20, 2019 12:00pm) https://events.umich.edu/event/64082 64082-16115266@events.umich.edu Event Begins: Friday, September 20, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Josie Clowney

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Workshop / Seminar Tue, 27 Aug 2019 17:12:34 -0400 2019-09-20T12:00:00-04:00 2019-09-20T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Confocal image of multicolor stained intact Drosophila larva
Science Forum Demo: Counting Cells (September 21, 2019 11:00am) https://events.umich.edu/event/63860 63860-16482915@events.umich.edu Event Begins: Saturday, September 21, 2019 11:00am
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world around you in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

The human body is made of more than 37 trillion cells. Most of them need to be replaced every couple of months, weeks, or sometimes in the course of only a few days. Our cells grow and divide constantly to get this massive job done. But how do cells replicate themselves? How do things move in, out, and around the cell, and into new cells? Join us as we explore how our bodies carry out this massive process. We will learn about cell structure and division and observe cells up-close and in action!
Funded by the National Science Foundation.

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Presentation Mon, 05 Aug 2019 09:35:06 -0400 2019-09-21T11:00:00-04:00 2019-09-21T11:20:00-04:00 Biological Sciences Building Museum of Natural History Presentation Biological Sciences Building
Biodiversity Lab Chat (September 21, 2019 3:30pm) https://events.umich.edu/event/62767 62767-16482955@events.umich.edu Event Begins: Saturday, September 21, 2019 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the website or Welcome Desk for times.

Join an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world. All ages welcome.

Wednesdays, 11 a.m.
Saturdays and Sundays, 3:30 pm.

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Other Mon, 05 Aug 2019 09:46:09 -0400 2019-09-21T15:30:00-04:00 2019-09-21T16:00:00-04:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
Science Forum Demo: Counting Cells (September 22, 2019 11:00am) https://events.umich.edu/event/63860 63860-16482920@events.umich.edu Event Begins: Sunday, September 22, 2019 11:00am
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world around you in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

The human body is made of more than 37 trillion cells. Most of them need to be replaced every couple of months, weeks, or sometimes in the course of only a few days. Our cells grow and divide constantly to get this massive job done. But how do cells replicate themselves? How do things move in, out, and around the cell, and into new cells? Join us as we explore how our bodies carry out this massive process. We will learn about cell structure and division and observe cells up-close and in action!
Funded by the National Science Foundation.

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Presentation Mon, 05 Aug 2019 09:35:06 -0400 2019-09-22T11:00:00-04:00 2019-09-22T11:20:00-04:00 Biological Sciences Building Museum of Natural History Presentation Biological Sciences Building
Biodiversity Lab Chat (September 22, 2019 3:30pm) https://events.umich.edu/event/62767 62767-16482960@events.umich.edu Event Begins: Sunday, September 22, 2019 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the website or Welcome Desk for times.

Join an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world. All ages welcome.

Wednesdays, 11 a.m.
Saturdays and Sundays, 3:30 pm.

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Other Mon, 05 Aug 2019 09:46:09 -0400 2019-09-22T15:30:00-04:00 2019-09-22T16:00:00-04:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
MedChem Seminar (September 23, 2019 10:00am) https://events.umich.edu/event/67530 67530-16890100@events.umich.edu Event Begins: Monday, September 23, 2019 10:00am
Location:
Organized By: Department of Medicinal Chemistry

"Chemistry & Biology of Human DNA Ligases"

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Lecture / Discussion Mon, 23 Sep 2019 10:18:45 -0400 2019-09-23T10:00:00-04:00 2019-09-23T11:00:00-04:00 Department of Medicinal Chemistry Lecture / Discussion
MedChem Seminar (September 23, 2019 10:00am) https://events.umich.edu/event/67530 67530-16890101@events.umich.edu Event Begins: Monday, September 23, 2019 10:00am
Location:
Organized By: Department of Medicinal Chemistry

"Chemistry & Biology of Human DNA Ligases"

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Lecture / Discussion Mon, 23 Sep 2019 10:18:45 -0400 2019-09-23T10:00:00-04:00 2019-09-23T11:00:00-04:00 Department of Medicinal Chemistry Lecture / Discussion
Seminar: Haining Zhong, Ph.D., Vollum Institute (September 24, 2019 10:00am) https://events.umich.edu/event/65687 65687-16629896@events.umich.edu Event Begins: Tuesday, September 24, 2019 10:00am
Location: Biological Sciences Building
Organized By: Life Sciences Institute (LSI)

Speaker:
Haining Zhong, Ph.D.
Associate Professor
Vollum Institute, Oregon Health & Science University

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Lecture / Discussion Fri, 23 Aug 2019 13:59:32 -0400 2019-09-24T10:00:00-04:00 2019-09-24T11:00:00-04:00 Biological Sciences Building Life Sciences Institute (LSI) Lecture / Discussion Biological Sciences Building
EEB Tuesday Lunch Seminar: Fantastic fishes and where to find them - using historical natural history data and robots to explore deep sea fish biodiversity (September 24, 2019 12:00pm) https://events.umich.edu/event/64996 64996-16501295@events.umich.edu Event Begins: Tuesday, September 24, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

The deep ocean is frequently assumed to be a homogeneous system lacking the same diverse natural history found in shallower waters. However, as our methods for exploring the deep ocean improve, common assumptions about dispersal, reproduction and behavior are constantly being challenged. With the immense amount of data collected and stored in natural history collections to highlight historical distributions of fishes we can now use these data in concert with modern sampling methods like remote operated vehicles (ROVs) and precision netting to learn more about one of the planets most extreme systems. Join Randy as he takes you on a journey from the highest shelves of museum collections to the extreme depths of the ocean in a quest to learn more about fishes, and where to find them.

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Workshop / Seminar Fri, 20 Sep 2019 09:50:00 -0400 2019-09-24T12:00:00-04:00 2019-09-24T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Museum fish specimen on display
Saltiel Life Sciences Symposium (September 25, 2019 8:45am) https://events.umich.edu/event/64209 64209-16212197@events.umich.edu Event Begins: Wednesday, September 25, 2019 8:45am
Location: Palmer Commons
Organized By: Life Sciences Institute (LSI)

The 2019 Saltiel Life Sciences Symposium will bring pioneers in the field of protein engineering to the University of Michigan to discuss the scientific advances driving the field forward.

Schedule:

8:45 a.m. | Welcome
Roger D. Cone, Ph.D.
Vice Provost and Director, U-M Biosciences Initiative; Mary Sue Coleman Director, Life Sciences Institute; Professor of Molecular and Integrative Physiology, Medical School; Professor of Molecular, Cellular, and Developmental Biology, College of Literature, Science, and the Arts

Mark S. Schlissel, M.D., Ph.D.
President of the University of Michigan

8:55 a.m. | Introduction of the Mary Sue and Kenneth Coleman Life Sciences Lecturer
Alan R. Saltiel, Ph.D.
Director, Institute for Diabetes and Metabolic Health, and Professor, University of California, San Diego School of Medicine; Director, Life Sciences Institute 2002-2015

9:00 a.m. | Mary Sue and Kenneth Coleman Life Sciences Lecture — Attacking the cell surface proteome in cancer
James A. Wells, Ph.D.
Harry W. and Diana V. Hind Distinguished Professor of Pharmaceutical Sciences, Professor of Pharmaceutical Chemistry, University of California, San Francisco

9:50 a.m. | Morning break

10:10 a.m. | Optogenetic and chemogenetic technologies for mapping molecular and cellular interactions
Alice Y. Ting, Ph.D.
Professor of Genetics, Biology, and Chemistry, Stanford University

11:00 a.m. | How do proteins evolve
Dan Tawfik, Ph.D.
Professor, Department of Biomolecular Sciences, Weizmann Institute of Science

11:50 a.m. | Poster session and lunch

1:20 p.m. | Biosystems design via directed evolution
Huimin Zhao, Ph.D.
Steven L. Miller Chair, Department of Chemical and Biomolecular Engineering; Professor of Chemistry, Biochemistry, Biophysics, an Bioengineering, University of Illinois at Urbana-Champaign

2:10 p.m. | Navigating the landscapes of protein interaction specificity
Amy E. Keating, Ph.D.Professor of Biology and Biological Engineering, Massachusetts Institute of Technology

3:00 p.m. | Afternoon break

3:20 p.m. |Design, evolution and applications of protein cages
Donald Hilvert, Ph.D.
Professor, Department of Chemistry and Applied Biosciences, ETH Zürich

4:10 p.m. | Closing remarks

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Conference / Symposium Thu, 29 Aug 2019 10:13:02 -0400 2019-09-25T08:45:00-04:00 2019-09-25T16:15:00-04:00 Palmer Commons Life Sciences Institute (LSI) Conference / Symposium 2019 Saltiel Life Sciences Symposium
Biodiversity Lab Chat (September 25, 2019 12:00pm) https://events.umich.edu/event/62767 62767-16909293@events.umich.edu Event Begins: Wednesday, September 25, 2019 12:00pm
Location:
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the website or Welcome Desk for times.

Join an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world. All ages welcome.

Wednesdays, 11 a.m.
Saturdays and Sundays, 3:30 pm.

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Other Mon, 05 Aug 2019 09:46:09 -0400 2019-09-25T12:00:00-04:00 2019-09-25T13:00:00-04:00 Museum of Natural History Other
Biodiversity Lab Chat (September 25, 2019 12:00pm) https://events.umich.edu/event/62767 62767-16909294@events.umich.edu Event Begins: Wednesday, September 25, 2019 12:00pm
Location:
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the website or Welcome Desk for times.

Join an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world. All ages welcome.

Wednesdays, 11 a.m.
Saturdays and Sundays, 3:30 pm.

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Other Mon, 05 Aug 2019 09:46:09 -0400 2019-09-25T12:00:00-04:00 2019-09-25T13:00:00-04:00 Museum of Natural History Other
DCMB Seminar, "Bioinformatics in Drug Discovery" (September 25, 2019 2:30pm) https://events.umich.edu/event/66407 66407-16734206@events.umich.edu Event Begins: Wednesday, September 25, 2019 2:30pm
Location: Taubman Biomedical Science Research Building
Organized By: DCMB Seminar Series

Abstract:
She’ll be describing the technologies and datasets her team uses to study human disease and develop new and improved treatments for their clients. She’ll cover the applications of traditional transcriptional profiling and sequence analysis as well as datasets and tools developed specifically for therapeutics development including CMap, Project Achilles, PRISM, functional CRISPR screening and others. She’ll also touch on topics like biomarker development, patient selection/stratification and gene therapy development. Along the way, she’ll describe what it’s like to work as a consultant, and how it differs from academic work or direct employment in the pharmaceutical industry.

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Lecture / Discussion Thu, 05 Sep 2019 11:01:32 -0400 2019-09-25T14:30:00-04:00 2019-09-25T15:30:00-04:00 Taubman Biomedical Science Research Building DCMB Seminar Series Lecture / Discussion
CDB-DEI Seminar - Oncomodulin an enigmatic parvalbumin protein (September 26, 2019 10:00am) https://events.umich.edu/event/65617 65617-16621824@events.umich.edu Event Begins: Thursday, September 26, 2019 10:00am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

2019 Cell & Developmental Biology Seminar Series

Hosted By:
Jacqueline Graniel- CDB Student
Ashley Velez- CDB Student
Flor Mendez- CDB Student

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Lecture / Discussion Thu, 22 Aug 2019 16:54:53 -0400 2019-09-26T10:00:00-04:00 2019-09-26T11:00:00-04:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion CDB Seminar - Simmons
EEB Thursday Seminar: The evolution of mammalian pregnancy: the path from pathology to physiology (September 26, 2019 4:00pm) https://events.umich.edu/event/65469 65469-16603596@events.umich.edu Event Begins: Thursday, September 26, 2019 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

There is a broadly recognized ambiguity in the relationship between mammalian (eutherian) pregnancy and inflammation. During implantation, inflammatory pathways are activated and important for successful implantation, but during the second trimester, intrauterine inflammation is a grave threat to the continuation of pregnancy. An investigation of the gene expression changes during opossum pregnancy led us to propose and test a model for the origin of eutherian implantation and pregnancy. In brief: if we take the opossum gestation as a model of the situation at the most recent common ancestor of marsupials and placental mammals, the evidence suggests that an acute inflammation is the result of the attachment of the trophoblast to the uterine epithelium. The difference between opossum and the eutherians is the outcome: In opossum the inflammation directly leads to parturition, while in eutherians inflammation never leads to neutrophil infiltration and soon is turned off. I will present evidence suggesting that one key innovation to achieve sustainable implantation was the origin of the decidual cell, which prevents the recruitment of neutrophils and thus prevents the development of an acute inflammation during implantation.

View YouTube video of seminar: https://youtu.be/cec0A_iwmLI

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Workshop / Seminar Mon, 06 Apr 2020 20:07:56 -0400 2019-09-26T16:00:00-04:00 2019-09-26T17:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Dr. Wagner EEB Seminar
MCDB Seminar: Tumor Initiation and Progression in a Simple Model (September 27, 2019 12:00pm) https://events.umich.edu/event/64085 64085-16115269@events.umich.edu Event Begins: Friday, September 27, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Laura Buttitta

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Workshop / Seminar Tue, 10 Sep 2019 16:53:29 -0400 2019-09-27T12:00:00-04:00 2019-09-27T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar transition zone model. showing Drosophila tissue stained blue
Oxidative Stress Sensing Mechanism by KEAP1 (September 27, 2019 2:00pm) https://events.umich.edu/event/65618 65618-16621825@events.umich.edu Event Begins: Friday, September 27, 2019 2:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

2019 Cell & Developmental Biology Seminar Series

Hosted By: Doug Engel, PhD

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Lecture / Discussion Thu, 22 Aug 2019 17:00:56 -0400 2019-09-27T14:00:00-04:00 2019-09-27T15:00:00-04:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion CDB Seminar - Yamamoto
Science Forum Demo: Counting Cells (September 28, 2019 11:00am) https://events.umich.edu/event/63860 63860-16482916@events.umich.edu Event Begins: Saturday, September 28, 2019 11:00am
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world around you in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

The human body is made of more than 37 trillion cells. Most of them need to be replaced every couple of months, weeks, or sometimes in the course of only a few days. Our cells grow and divide constantly to get this massive job done. But how do cells replicate themselves? How do things move in, out, and around the cell, and into new cells? Join us as we explore how our bodies carry out this massive process. We will learn about cell structure and division and observe cells up-close and in action!
Funded by the National Science Foundation.

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Presentation Mon, 05 Aug 2019 09:35:06 -0400 2019-09-28T11:00:00-04:00 2019-09-28T11:20:00-04:00 Biological Sciences Building Museum of Natural History Presentation Biological Sciences Building
Biodiversity Lab Chat (September 28, 2019 3:30pm) https://events.umich.edu/event/62767 62767-16482956@events.umich.edu Event Begins: Saturday, September 28, 2019 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the website or Welcome Desk for times.

Join an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world. All ages welcome.

Wednesdays, 11 a.m.
Saturdays and Sundays, 3:30 pm.

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Other Mon, 05 Aug 2019 09:46:09 -0400 2019-09-28T15:30:00-04:00 2019-09-28T15:45:00-04:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
Science Forum Demo: Counting Cells (September 29, 2019 11:00am) https://events.umich.edu/event/63860 63860-16482921@events.umich.edu Event Begins: Sunday, September 29, 2019 11:00am
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world around you in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

The human body is made of more than 37 trillion cells. Most of them need to be replaced every couple of months, weeks, or sometimes in the course of only a few days. Our cells grow and divide constantly to get this massive job done. But how do cells replicate themselves? How do things move in, out, and around the cell, and into new cells? Join us as we explore how our bodies carry out this massive process. We will learn about cell structure and division and observe cells up-close and in action!
Funded by the National Science Foundation.

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Presentation Mon, 05 Aug 2019 09:35:06 -0400 2019-09-29T11:00:00-04:00 2019-09-29T11:20:00-04:00 Biological Sciences Building Museum of Natural History Presentation Biological Sciences Building
Biodiversity Lab Chat (September 29, 2019 3:30pm) https://events.umich.edu/event/62767 62767-16482961@events.umich.edu Event Begins: Sunday, September 29, 2019 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the website or Welcome Desk for times.

Join an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world. All ages welcome.

Wednesdays, 11 a.m.
Saturdays and Sundays, 3:30 pm.

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Other Mon, 05 Aug 2019 09:46:09 -0400 2019-09-29T15:30:00-04:00 2019-09-29T15:45:00-04:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
"RNA Therapeutics: The Future of Human Medicine" (September 30, 2019 4:00pm) https://events.umich.edu/event/65135 65135-16539446@events.umich.edu Event Begins: Monday, September 30, 2019 4:00pm
Location: Palmer Commons
Organized By: Center for RNA Biomedicine

Please join us immediately after Anastasia's talk for a welcome reception in Palmer Commons Atrium (4th floor).


ABSTRACT: With the first drugs approved, oligonucleotides are rising to become a new, major class of therapeutic modalities on par with small molecules and biologics.
RNAi enables simple and specific modulation of gene expression when the chemical architecture supporting efficient delivery in vivo is defined. Currently, in liver, a single subcutaneous administration supports a year of clinical efficacy, changing our vision of how medicine will be practiced in the future.
The unprecedented duration of effect relies on oligonucleotide endocytosis and entrapment within endosomal/lysosomal compartments. These naturally formed, intracellular deposits provide a continuous release of compounds for RISC loading and productive silencing, supporting multi-month efficacy. Of course, this approach is dependent on extensive and complex chemical stabilization that ensures the survival of the oligonucleotides in highly aggressive biological environments.
In the context of fully stabilized compounds, we have used diverse chemical engineering to define the rules driving oligonucleotide distribution, efficacy, and toxicity. At this point, efficient modulation of gene expression in multiple extrahepatic tissues is possible (muscle, heart, fat, placenta, etc). One of our engineering efforts resulted in the identification of a di-branched chemical scaffold that enables potent and durable gene silencing in the brain and spinal cord. Using huntingtin – the causative gene in Huntington disease – as a model, we demonstrate that CNS-active RNAi induces potent protein silencing (~ 90%) in all brain regions tested in both rodents and non-human primates. Silencing persists for at least six months, with the degree of gene modulation correlating to the level of the guide strand tissue accumulation.
Demonstration of extrahepatic activity, in particular the development of a CNS-active RNAi scaffold, is opening other tissues and the brain for RNAi-based modulation of gene expression and establishing a path toward the development of new cures for genetically-defined neurodegenerative disorders.

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Lecture / Discussion Fri, 13 Sep 2019 13:47:57 -0400 2019-09-30T16:00:00-04:00 2019-09-30T17:00:00-04:00 Palmer Commons Center for RNA Biomedicine Lecture / Discussion speaker photo
EEB Tuesday Lunch Seminar: Imperiled plants of tropical rivers: Phylogeny, biogeography, and systematics of Podostemaceae (October 1, 2019 12:00pm) https://events.umich.edu/event/64998 64998-16501296@events.umich.edu Event Begins: Tuesday, October 1, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Please join us for our weekly brown bag lunch seminar

Abstract
The riverweed family (Podostemaceae) is the largest strictly aquatic family of flowering plants and provides important habitats and food sources for many fishes and aquatic invertebrates. Highly unusual for flowering plants, species grow directly attached to rocks in river-rapids and waterfalls. Podostemaceae species exhibit high phenotypic plasticity and have highly modified growth forms, both of which contribute to taxonomic confusion. Many of the estimated 300 riverweed species are narrowly distributed and incompletely known, and evolutionary relationships within the family are uncertain. Unfortunately, many species are of conservation concern and risk extinction due to the expansion of hydroelectric dams and massive reservoirs. This talk will detail the progress on a collaborative project to better understand the phylogeny, biogeography, and systematics of Podostemaceae. In particular, we aim to better understand the biogeographical history of neotropical riverine organisms and the role that major river capture events during the Cenozoic have played in their distribution. The project includes significant fieldwork, monographic work, and an investigation of the structural organization of the family’s plastid genome. Finally, we are also developing a new online resource designed to broadly disseminate information on the family as well as a new tool for the systematics community to more easily manage monographic data for publication.

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Workshop / Seminar Tue, 24 Sep 2019 14:24:34 -0400 2019-10-01T12:00:00-04:00 2019-10-01T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Riverweed
A periosteal stem cell and the cellular basis of intramembranous versus endochondral ossification (October 1, 2019 4:00pm) https://events.umich.edu/event/65743 65743-16651986@events.umich.edu Event Begins: Tuesday, October 1, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for Cell Plasticity and Organ Design

2019 - 2020 Center for Organogenesis Seminar Series
Faculty Host: Noriaki Ono
For additional information contact: organogenesis@umich.edu

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Lecture / Discussion Mon, 26 Aug 2019 09:00:56 -0400 2019-10-01T16:00:00-04:00 2019-10-01T17:00:00-04:00 Taubman Biomedical Science Research Building Center for Cell Plasticity and Organ Design Lecture / Discussion A periosteal stem cell and the cellular basis of intramembranous versus endochondral ossification.”
Special Joint Lecture (MICHR and DCMB) (October 2, 2019 4:00pm) https://events.umich.edu/event/67257 67257-16829032@events.umich.edu Event Begins: Wednesday, October 2, 2019 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract: Dr. Haendel’s vision is to weave together healthcare systems, basic science research, and patient generated data through development of data integration technologies and innovative data capture strategies. The Monarch Initiative is an international consortium dedicated to integrating human and organismal genotype-phenotype data and the development of deep phenotyping techniques. This talk will focus on the use of ontologies to support knowledge and data integration across disciplinary boundaries. Strategies for how to reconcile different terminologies and examples of harmonized semantic structures for anatomy, phenotype, and disease will be discussed. Finally, we will discuss the use of these ontological resources to populate graph structures and their use to aid mechanism discovery and rare disease diagnosis.

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Lecture / Discussion Mon, 16 Sep 2019 11:53:44 -0400 2019-10-02T16:00:00-04:00 2019-10-02T17:00:00-04:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
EEB Thursday Seminar: Locating and learning from bright spots among the world’s coral reefs (October 3, 2019 4:00pm) https://events.umich.edu/event/65470 65470-16660096@events.umich.edu Event Begins: Thursday, October 3, 2019 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

The continuing and rapid global decline of coral reefs calls for new approaches to sustain reefs and the millions of people who depend on them. In this talk, I present ongoing work by my research group aimed at rethinking reef conservation along two lines. First is directly confronting the drivers of change. In addition to environmental factors, there are socioeconomic drivers that influence the condition of coral reef ecosystems, though reef governance rarely focus on explicitly managing these. My colleagues and I analyzed data from >1800 tropical reef sites worldwide to quantify how key socioeconomic and environmental drivers are related to reef fish biomass, a key indicator of ecosystem condition and resource availability. Our global analysis reveals that the strongest driver of reef fish biomass is our metric of potential interactions with urban centres (market gravity), with important, but smaller, roles of local management, human demographics, socioeconomic development, and environmental conditions. These results highlight multiple underutilized policy levers that could help to sustain coral reefs, such as dampening the negative impact of markets. Second, drawing on theory and practice in human health and rural development, we use a positive deviance (bright spots) analysis to systematically identify coral reefs that have substantially higher biomass than expected, given their socioeconomic and environmental conditions. Importantly, bright spots were not simply comprised of remote areas with low fishing pressure- they include localities where human populations and use of ecosystems resources is high, potentially providing novel insights into how communities have successfully confronted strong drivers of change. Uncovering the mechanisms that underpin the ability of bright spots to confront high pressures may form a basis for novel policy approaches.

View YouTube video of seminar: https://youtu.be/qVywZwcWMiY

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Workshop / Seminar Thu, 02 Apr 2020 12:52:07 -0400 2019-10-03T16:00:00-04:00 2019-10-03T17:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Cinner photo
MedChem Seminar (October 3, 2019 4:00pm) https://events.umich.edu/event/67530 67530-16890098@events.umich.edu Event Begins: Thursday, October 3, 2019 4:00pm
Location: Pharmacy College
Organized By: Department of Medicinal Chemistry

"Chemistry & Biology of Human DNA Ligases"

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Lecture / Discussion Mon, 23 Sep 2019 10:18:45 -0400 2019-10-03T16:00:00-04:00 2019-10-03T17:00:00-04:00 Pharmacy College Department of Medicinal Chemistry Lecture / Discussion Pharmacy College
Diversity and Ecology of Virus in Human Health and the Environment (October 4, 2019 9:00am) https://events.umich.edu/event/66118 66118-16687427@events.umich.edu Event Begins: Friday, October 4, 2019 9:00am
Location: Public Health II
Organized By: MAC-EPID

MAC-EPID symposia are designed to stimulate conversation across disciplines therefore time is allotted to breaks and lunch to allow for these connections.

Speakers include:

Simon Roux, PhD (Research Scientist, DOE Joint Genome Institute, Lawrence Berkeley National Laboratory)
"Viruses in the environment: ruthless killers or essential helpers of microbes?"

Nathan Grubaugh, PhD (Assistant Professor of Epidemiology of Microbial Diseases, Yale School of Public Health)
"Genomic epidemiology to uncover the emergence and spread of Zika virus"

Sarah Cobey (Associate Professor, Ecology & Evolution, University of Chicago)
Title TBA


Please register for this free symposium since lunch will be provided. Thank you!

* * * * *

For more information and registration for this FREE event:
www.MAC-EPID.org
Anna Cronenwett, weaverd@umich.edu

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Conference / Symposium Fri, 30 Aug 2019 18:01:48 -0400 2019-10-04T09:00:00-04:00 2019-10-04T15:00:00-04:00 Public Health II MAC-EPID Conference / Symposium MAC-EPID flyer 2019
MCDB Seminar: RNA Binding Proteins, Cancer-Induced Cachexia--Potential Therapy (October 4, 2019 12:00pm) https://events.umich.edu/event/67346 67346-16839903@events.umich.edu Event Begins: Friday, October 4, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Mohammed Akaaboune

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Workshop / Seminar Tue, 17 Sep 2019 15:29:02 -0400 2019-10-04T12:00:00-04:00 2019-10-04T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar collage of micrographs with MCDB letters
Science Forum Demo: Counting Cells (October 5, 2019 11:00am) https://events.umich.edu/event/66397 66397-16734165@events.umich.edu Event Begins: Saturday, October 5, 2019 11:00am
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world around you in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

The human body is made of more than 37 trillion cells. Most of them need to be replaced every couple of months, weeks, or sometimes in the course of only a few days. Our cells grow and divide constantly to get this massive job done. But how do cells replicate themselves? How do things move in, out, and around the cell, and into new cells? Join us as we explore how our bodies carry out this massive process. We will learn about cell structure and division and observe cells up-close and in action! Funded by the National Science Foundation.

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Presentation Thu, 05 Sep 2019 12:02:34 -0400 2019-10-05T11:00:00-04:00 2019-10-05T11:20:00-04:00 Biological Sciences Building Museum of Natural History Presentation Biological Sciences Building
Biodiversity Lab Chat (October 5, 2019 3:30pm) https://events.umich.edu/event/66426 66426-16736289@events.umich.edu Event Begins: Saturday, October 5, 2019 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the website or Welcome Desk for times.

Stop by and chat with an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world.

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Other Thu, 26 Sep 2019 12:44:56 -0400 2019-10-05T15:30:00-04:00 2019-10-05T15:45:00-04:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
Science Forum Demo: Counting Cells (October 6, 2019 11:00am) https://events.umich.edu/event/66397 66397-16734169@events.umich.edu Event Begins: Sunday, October 6, 2019 11:00am
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world around you in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

The human body is made of more than 37 trillion cells. Most of them need to be replaced every couple of months, weeks, or sometimes in the course of only a few days. Our cells grow and divide constantly to get this massive job done. But how do cells replicate themselves? How do things move in, out, and around the cell, and into new cells? Join us as we explore how our bodies carry out this massive process. We will learn about cell structure and division and observe cells up-close and in action! Funded by the National Science Foundation.

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Presentation Thu, 05 Sep 2019 12:02:34 -0400 2019-10-06T11:00:00-04:00 2019-10-06T11:20:00-04:00 Biological Sciences Building Museum of Natural History Presentation Biological Sciences Building
Biodiversity Lab Chat (October 6, 2019 3:30pm) https://events.umich.edu/event/66426 66426-16736293@events.umich.edu Event Begins: Sunday, October 6, 2019 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the website or Welcome Desk for times.

Stop by and chat with an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world.

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Other Thu, 26 Sep 2019 12:44:56 -0400 2019-10-06T15:30:00-04:00 2019-10-06T15:45:00-04:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
RNA Innovation Seminar, Keith Slotkin, Donald Danforth Plant Science Center, University of Missouri Columbia (October 7, 2019 4:00pm) https://events.umich.edu/event/65136 65136-16539447@events.umich.edu Event Begins: Monday, October 7, 2019 4:00pm
Location: Palmer Commons
Organized By: Center for RNA Biomedicine

Keith Slotkin, Member and PI, Donald Danforth Plant Science Center,  Associate Professor, Division of Biological Sciences, University of Missouri Columbia

Abstract: The field of epigenetic silencing is replete with labs studying how transcriptional silencing is epigenetically maintained, or in some cases re-targeted, across cell divisions and generations. On the other hand, the initiation of that silencing in the first place, especially for DNA that is “new” to the genome, is not well understood. Although the propagation of epigenetic silencing is based on the chromatin level, our data in the powerful model plant Arabidopsis demonstrates that de novo initiation of transposable element and transgene silencing is based on RNA, and utilizes a host of small RNA classes that function specifically in the initiation of silencing to guide the first round of DNA methylation. I plan to present my ongoing work on the molecular mechanisms of silencing initiation, focusing on the key RNA-dependent processes necessary to initiate epigenetic silencing.

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Lecture / Discussion Wed, 25 Sep 2019 10:57:47 -0400 2019-10-07T16:00:00-04:00 2019-10-07T17:00:00-04:00 Palmer Commons Center for RNA Biomedicine Lecture / Discussion flyer
Biocatalysis of Paclitaxel Analogs and Hydroxy Amino Acids- Department of Biological Chemistry Seminar (October 8, 2019 12:00pm) https://events.umich.edu/event/67256 67256-16829030@events.umich.edu Event Begins: Tuesday, October 8, 2019 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Kevin Walker, Professor of Chemistry at Michigan State University, will give the Department of Biological Chemistry seminar on Tuesday October 8th at 12 noon in North Lecture Hall, MS II

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Workshop / Seminar Mon, 16 Sep 2019 11:24:15 -0400 2019-10-08T12:00:00-04:00 2019-10-08T13:00:00-04:00 Medical Science Unit II Biological Chemistry Workshop / Seminar
EEB Tuesday Lunch Seminar: Fuel treatments change forest structure and spatial patterns of fire severity in dry western forests (October 8, 2019 12:00pm) https://events.umich.edu/event/64999 64999-16501297@events.umich.edu Event Begins: Tuesday, October 8, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Please join us for our weekly brown bag lunch seminar.

Abstract
Fuel reduction treatments are often designed to achieve multiple resource management objectives in addition to reducing potential fire hazard. Many studies have documented reduced fire severity for a standard set of fuel treatments, but the range of variability in fuel treatment effectiveness for alternative treatment designs is poorly understood. We used nonlinear mixed-effects modeling to estimate the distance into the treated area at which fire severity decreases and randomization tests to compare forest structure. The range of variability in observed-distance high-severity fire effects persist into the treated area and, in conjunction with estimated relationships between posttreatment forest structure and severity, can inform the design of alternative fuel treatment prescriptions with various target prescriptions. Our study will inform decision makers on the size of treatments required to accomplish management objectives.

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Workshop / Seminar Fri, 04 Oct 2019 10:34:29 -0400 2019-10-08T12:00:00-04:00 2019-10-08T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar View from above of forest fire and unburned area and land beyond
Solving the Polyploid Mystery in Wound Repair (October 8, 2019 4:00pm) https://events.umich.edu/event/65744 65744-16651987@events.umich.edu Event Begins: Tuesday, October 8, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for Cell Plasticity and Organ Design

2019 – 2020 Center for Organogenesis Seminar Series
Faculty Host: Laura Buttitta

For additional information contact: organogenesis@umich.edu

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Lecture / Discussion Fri, 13 Sep 2019 10:43:05 -0400 2019-10-08T16:00:00-04:00 2019-10-08T17:00:00-04:00 Taubman Biomedical Science Research Building Center for Cell Plasticity and Organ Design Lecture / Discussion Solving the Polyploid Mystery in Wound Repair_2
Medical School Student Panel Discussion (October 8, 2019 6:00pm) https://events.umich.edu/event/65981 65981-16678384@events.umich.edu Event Begins: Tuesday, October 8, 2019 6:00pm
Location: Biological Sciences Building
Organized By: Science Learning Center

Here is your chance to hear about what life is like for several medical school students and residents. Learn about each of their paths to medicine, experiences in medical school, and things they wished they had known in college. You can also submit your own questions ahead of time using the following link: http://tiny.cc/med-student-panel.

Registration Link: http://ttc.iss.lsa.umich.edu/undergrad/sessions/medical-school-student-panel-discussion-2/

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Workshop / Seminar Wed, 04 Sep 2019 15:40:54 -0400 2019-10-08T18:00:00-04:00 2019-10-08T19:00:00-04:00 Biological Sciences Building Science Learning Center Workshop / Seminar Biological Sciences Building
Biology DEI Event (October 9, 2019 1:30pm) https://events.umich.edu/event/68088 68088-17009817@events.umich.edu Event Begins: Wednesday, October 9, 2019 1:30pm
Location: Biological Sciences Building
Organized By: MCDB Graduate Student Council - MCDB-GSC

As part of Biology Week, the MCDB and EEB DE&I Committees will be hosting an information session on summer research opportunities for undergraduate students. We will also have a presentation from the Society for the Advancement of Chicanos/Hispanics and Native Americans in Science (SACNAS) organization. In addition, we will be hosting a Draw a Scientist Activity where we invite all undergrads, graduate students, postdocs, and even faculty to draw cartoon versions of themselves as scientists. These drawings will be displayed during our outreach events later in the week.
There will be free pizza at this event.

Room and Time: 1010 BSB, 1:30pm - 2:30pm

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Workshop / Seminar Mon, 07 Oct 2019 10:14:26 -0400 2019-10-09T13:30:00-04:00 2019-10-09T14:30:00-04:00 Biological Sciences Building MCDB Graduate Student Council - MCDB-GSC Workshop / Seminar Biological Sciences Building
Department of Computational Medicine & Bioinformatics Weekly Wednesday Seminar (October 9, 2019 4:00pm) https://events.umich.edu/event/68092 68092-17009821@events.umich.edu Event Begins: Wednesday, October 9, 2019 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Talk Title: "Controlling dynamic ensembles: From cells to societies"

Abstract: Natural and engineered systems that consist of populations of isolated or interacting dynamical components exhibit levels of complexity that are beyond human comprehension. These complex systems often require an appropriate excitation, an optimal hierarchical organization, or a periodic dynamical structure, such as synchrony, to function as desired or operate optimally. In many application domains, e.g., neurostimulation in brain medicine and nuclear magnetic resonance spectroscopy and imaging in quantum control, control and observation can only be implemented at the population level, through broadcasting a single input signal to all the systems in the population and through collecting aggregated system-level measurements of the population, respectively. These limitations give rise to challenging problems and new control paradigms involving underactuated manipulation of dynamic ensembles. This talk will address theoretical and computational challenges for targeted coordination of both isolated and networked ensemble systems arising in diverse areas at different scales. Both model-based and data-driven approaches for learning, decoding, control, and computation of dynamic structures and patterns in ensemble systems will be presented. Practical control designs, including synchronization waveforms for pattern formation in complex networks and optimal pulses in quantum control, will be illustrated along with their experimental realizations. Lastly, future directions and opportunities in Systems and Controls will be discussed.

3:45 p.m. - Light Refreshments Served
4:00 p.m. - Lecture

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Lecture / Discussion Mon, 07 Oct 2019 10:26:01 -0400 2019-10-09T16:00:00-04:00 2019-10-09T17:00:00-04:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
Professor Jianzhi Zhang, the Marshall W. Nirenberg Collegiate Professor of Ecology and Evolutionary Biology, Inaugural Lecture (October 9, 2019 4:00pm) https://events.umich.edu/event/64418 64418-16346364@events.umich.edu Event Begins: Wednesday, October 9, 2019 4:00pm
Location: Weiser Hall
Organized By: The College of Literature, Science, and the Arts

Molecular errors refer to mistakes made at the molecular level in cells, including, for example, misfolding of RNA or protein molecules, misincorporation of amino acids in protein synthesis, and misinteraction between biomolecules. I argue that many genome-scale patterns in molecular biology and evolution (e.g., on transcription/translation initiation site variation, alternative polyadenylation, posttranscriptional modification, chromosomal locations of genes, and protein evolutionary rate) originate from molecular errors and differential natural selection mitigating these errors. Realizing that the cellular life is far from the orderly and harmonious picture commonly portrayed is important for understanding biology.

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Lecture / Discussion Mon, 07 Oct 2019 19:42:24 -0400 2019-10-09T16:00:00-04:00 2019-10-09T17:30:00-04:00 Weiser Hall The College of Literature, Science, and the Arts Lecture / Discussion Picture
BME 500 Seminar: Erin Purcell (October 10, 2019 9:00am) https://events.umich.edu/event/68034 68034-16986101@events.umich.edu Event Begins: Thursday, October 10, 2019 9:00am
Location: Chrysler Center
Organized By: Biomedical Engineering

By stimulating or recording electrical activity, microelectrode arrays implanted in the brain have created a renaissance in the treatment of neurological diseases and injuries. Likewise, these devices are an enabling technology to understand normal brain function and behavior. However, questions remain regarding the relationship between the biological response to implanted electrodes, their chronic performance, and features of their design. It is my lab’s goal to understand the basic science underlying the interaction between implanted electrodes and brain cells, and to provide guiding principles to improve device design and performance as a result. Recently, we have found novel effects of implanted silicon and polyimide-based electrode arrays on the structure and function of local neurons, including alterations in ion channel expression, synaptic transporter expression, dendritic spine density, and excitability. Results of quantitative immunohistochemistry demonstrate a progressive local increase in the expression of potassium ion channels and inhibitory transporters surrounding devices implanted in the brains of rats over time, indicating a potential shift toward hypoexcitability over the 6-week time course studied. Two-photon laser scanning microscopy in brain slice preparations revealed profound local spine loss surrounding implants, coupled with observations of reduced responsiveness to injected current during whole cell intracellular recordings, where preliminary observations indicate particularly pronounced effects surrounding silicon-based devices. More recently, we have pursued RNA-sequencing to understand the molecular identity and function of neurons and non-neurons surrounding implanted electrodes. Our results suggest a novel role of local plasticity surrounding devices in chronic signal loss and instability, and we are currently working to assess and perturb local gene expression to reveal potential underlying mechanisms.

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Lecture / Discussion Fri, 04 Oct 2019 15:50:14 -0400 2019-10-10T09:00:00-04:00 2019-10-10T10:00:00-04:00 Chrysler Center Biomedical Engineering Lecture / Discussion BME Logo
CGIS Study Abroad Fair (October 10, 2019 12:00pm) https://events.umich.edu/event/64876 64876-16483057@events.umich.edu Event Begins: Thursday, October 10, 2019 12:00pm
Location: Michigan League
Organized By: Center for Global and Intercultural Study

Learn about 140 programs in over 50 countries, ask about U-M faculty-led programs, and figure out which program can help satisfy your major/minor requirements. CGIS has programs ranging from 3 weeks to an academic year! Meet with CGIS advisors, staff from the Office of Financial Aid and the LSA Scholarship Office, CGIS
Alumni, and other on-campus offices who can help you select a program that works best for you.

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Fair / Festival Thu, 15 Aug 2019 13:41:18 -0400 2019-10-10T12:00:00-04:00 2019-10-10T16:00:00-04:00 Michigan League Center for Global and Intercultural Study Fair / Festival PHOTO
LSI Seminar Series: Hanchuan Peng, Ph.D., Allen Institute for Brain Science (October 10, 2019 12:00pm) https://events.umich.edu/event/67683 67683-16917832@events.umich.edu Event Begins: Thursday, October 10, 2019 12:00pm
Location: Palmer Commons
Organized By: Life Sciences Institute (LSI)

Abstract:
Despite substantial advancement in the automatic tracing of brain cells' 3D morphology in recent years, it is challenging to apply existing algorithms to very large image datasets containing billions or more voxels, especially for applications such as morphometry of single neurons at the whole-brain scale. We have developed a new platform combining several newly developed technologies including Vaa3D, TeraFly, UltraTracer, and TeraVR (Nature, 2019), to attempt this challenge. Particularly, we have used TeraFly to invoke Vaa3D to quickly visualize the whole mouse brain image volume and manage the thousands of billions of voxels in each of the brain volume. We then used UltraTracer to wrap several efficient base tracers to trace such massive data volumes. Finally, we combined virtual reality and machine learning into a tool called TeraVR for efficient proofreading and editing of such reconstructed neuron morphology. We are further improving the integration of these tools for more scalable and accurate single neuron morphometry.

Speaker:
Hanchuan Peng is the director of the SEU-ALLEN Joint Center and director of advanced computing at the Allen Institute for Brain Science. His lab develops revolutionary technologies to generate, manage, visualize, analyze and understand massive-scale structure and function data related to brains. Peng also led the Big Image Mining team at Janelia, HHMI. Peng is a highly cited inventor of a number of new algorithms and software/hardware systems, including Vaa3D - a widely adopted high-performance platform for very large multi-dimensional images, BrainAligner, SmartScope, mRMR, etc. He built and co-worked the first digital maps for several widely used model systems at single cell/neurite resolution, and led the “BigNeuron” initiative. Peng was inducted into AIMBE in 2019, is a co-recipient of USA National Academy of Sciences’ Cozzarelli Prize (2013), and a recipient of the DIADEM award (2010). His work has been featured in Nature, Science, NPR, and NBC, among others.

Lunch will be provided.

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Lecture / Discussion Thu, 26 Sep 2019 13:13:18 -0400 2019-10-10T12:00:00-04:00 2019-10-10T13:00:00-04:00 Palmer Commons Life Sciences Institute (LSI) Lecture / Discussion LSI Seminar Series
EEB Thursday Seminar: Inferring the evolutionary timescale of vascular plant evolution (October 10, 2019 4:00pm) https://events.umich.edu/event/65471 65471-16603598@events.umich.edu Event Begins: Thursday, October 10, 2019 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Methods for inferring divergence times from molecular phylogenies are highly contentious. The majority of the applications of the classic "node-based" approach rely heavily on individual researchers' implicit assumptions about patterns of morphological evolution and the fossilization process. The application of these methods to understanding the evolution of vascular plants has been particularly controversial, yielding divergence time estimates often seen as incompatible with the fossil record. However, "total-evidence dating" (TED) methodologies offer the opportunity to overcome the difficulties inherent in the traditional node-based approaches, allowing for the simultaneous inference of the phylogenetic relationships of extant and extinct vascular plants, their divergence times, and their patterns of morphological evolution. As part of a broader project to infer the timeline of vascular plant evolution, I will discuss results of the application of TED approaches to the Marattiales, a eusporangiate fern lineage with a deep fossil record (Marattiales taxa were dominant components of Carboniferous coal swamps), and close with comments on the challenges in implementing TED analyses, and in particular, in applying defensible models of morphological evolution.

View YouTube video of seminar: https://youtu.be/PEdhz9BuJbU

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Workshop / Seminar Fri, 10 Apr 2020 14:15:36 -0400 2019-10-10T16:00:00-04:00 2019-10-10T17:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Vascular plant evolution painting. Credit Tom Phillips
Graduate student panel (October 10, 2019 5:00pm) https://events.umich.edu/event/67688 67688-16918010@events.umich.edu Event Begins: Thursday, October 10, 2019 5:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

As part of Biology Week, graduate students from the Department of Molecular, Cellular and Developmental Biology and the Department of Ecology and Evolutionary Biology are holding a panel on applying to graduate school and general advice on handling the first couple years of grad school.

They will answer questions on the graduate school application process and on the transition from undergraduate to graduate level research. The panel will be followed by a make-your-own-ice cream mixer.

Image credit: Tao Wan

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Lecture / Discussion Thu, 26 Sep 2019 15:57:20 -0400 2019-10-10T17:00:00-04:00 2019-10-10T19:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Lecture / Discussion Two pronghorns walking past in a beautiful setting at Yellowstone National Park
MCDB and EEB Graduate School Panel (October 10, 2019 5:00pm) https://events.umich.edu/event/67778 67778-16949872@events.umich.edu Event Begins: Thursday, October 10, 2019 5:00pm
Location: Biological Sciences Building
Organized By: Program in Biology

Graduate School Panel

Description: Biology graduate students are holding a panel to answer questions on the grad school application process and give general advice on the transition from undergraduate to graduate level research. The panel will be followed by a make-your-own-ice cream mixer.

When: October 10th, at 5pm

Where: 1010 BSB

Thank you!
Biology Week Joint Planning Committee

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Meeting Wed, 02 Oct 2019 22:59:00 -0400 2019-10-10T17:00:00-04:00 2019-10-10T18:00:00-04:00 Biological Sciences Building Program in Biology Meeting Biological Sciences Building
MCDB Seminar: Temperature Sensing and Preference in Drosophila (October 11, 2019 12:00pm) https://events.umich.edu/event/67350 67350-16839923@events.umich.edu Event Begins: Friday, October 11, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Monica Dus

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Workshop / Seminar Tue, 17 Sep 2019 16:11:36 -0400 2019-10-11T12:00:00-04:00 2019-10-11T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar cartoon of large Drosophila fly and city in flames
BME Talk: David Nordsletten (October 11, 2019 3:00pm) https://events.umich.edu/event/68252 68252-17035297@events.umich.edu Event Begins: Friday, October 11, 2019 3:00pm
Location: East Hall
Organized By: Biomedical Engineering

The human heart is a complex electromechanical pump, translating electrophysiological stimulation into tissue contraction and the ejection of blood from its chambers to drive cardiovascular blood flow. Despite being incredibly adaptable and robust, the human heart can experience a myriad of maladies leading to disruption and dysfunction. Core to cardiac physiology, and pathophysiology, is the efficient interaction between solid tissue and blood, translating mechanical work into blood flow. Understanding this interaction, principles of fluid mechanics, turbulence and fluid-structure interaction provide a core foundation. From recent work on image-based estimation of pressure loss, to analytic solutions and computational methods for fluid-structure interaction, to multigrid-in-time, this talk will explore some of the mathematical techniques useful for evaluating the behavior of blood and its impact on the heart.

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Lecture / Discussion Thu, 10 Oct 2019 11:09:57 -0400 2019-10-11T15:00:00-04:00 2019-10-11T15:50:00-04:00 East Hall Biomedical Engineering Lecture / Discussion BME Logo
Science Forum Demo: Counting Cells (October 12, 2019 11:00am) https://events.umich.edu/event/66397 66397-16734166@events.umich.edu Event Begins: Saturday, October 12, 2019 11:00am
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world around you in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

The human body is made of more than 37 trillion cells. Most of them need to be replaced every couple of months, weeks, or sometimes in the course of only a few days. Our cells grow and divide constantly to get this massive job done. But how do cells replicate themselves? How do things move in, out, and around the cell, and into new cells? Join us as we explore how our bodies carry out this massive process. We will learn about cell structure and division and observe cells up-close and in action! Funded by the National Science Foundation.

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Presentation Thu, 05 Sep 2019 12:02:34 -0400 2019-10-12T11:00:00-04:00 2019-10-12T11:20:00-04:00 Biological Sciences Building Museum of Natural History Presentation Biological Sciences Building
Biodiversity Lab Chat (October 12, 2019 3:30pm) https://events.umich.edu/event/66426 66426-16736290@events.umich.edu Event Begins: Saturday, October 12, 2019 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the website or Welcome Desk for times.

Stop by and chat with an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world.

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Other Thu, 26 Sep 2019 12:44:56 -0400 2019-10-12T15:30:00-04:00 2019-10-12T15:45:00-04:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
Science Forum Demo: Counting Cells (October 13, 2019 11:00am) https://events.umich.edu/event/66397 66397-16734170@events.umich.edu Event Begins: Sunday, October 13, 2019 11:00am
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world around you in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

The human body is made of more than 37 trillion cells. Most of them need to be replaced every couple of months, weeks, or sometimes in the course of only a few days. Our cells grow and divide constantly to get this massive job done. But how do cells replicate themselves? How do things move in, out, and around the cell, and into new cells? Join us as we explore how our bodies carry out this massive process. We will learn about cell structure and division and observe cells up-close and in action! Funded by the National Science Foundation.

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Presentation Thu, 05 Sep 2019 12:02:34 -0400 2019-10-13T11:00:00-04:00 2019-10-13T11:20:00-04:00 Biological Sciences Building Museum of Natural History Presentation Biological Sciences Building
Biodiversity Lab Chat (October 13, 2019 3:30pm) https://events.umich.edu/event/66426 66426-16736294@events.umich.edu Event Begins: Sunday, October 13, 2019 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the website or Welcome Desk for times.

Stop by and chat with an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world.

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Other Thu, 26 Sep 2019 12:44:56 -0400 2019-10-13T15:30:00-04:00 2019-10-13T15:45:00-04:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
RNA Innovation Seminar, Ailong Ke, Cornell University (October 14, 2019 4:00pm) https://events.umich.edu/event/65137 65137-16539448@events.umich.edu Event Begins: Monday, October 14, 2019 4:00pm
Location: Palmer Commons
Organized By: Center for RNA Biomedicine

Ailong Ke PhD, Professor, Department of Molecular Biology and Genetics, Cornell University

Abstract: CRISPR-Cas serves as an RNA-based adaptive immunity system in prokaryotes. The diverse CRISPR systems can be categorized into two major classes and multiple types therein. Type I CRISPR-Cas (or CRISPR-Cas3) belongs to Class 1 and is the most prevalent CRISPR system found in nature. It features a sequential target-searching and degradation process. First, the target-searching complex Cascade (CRISPR associated complex for antiviral defense) uses its guide RNA to find the complementary dsDNA target, and opens a special structure called R-loop at the target site. Its helicase-nuclease fusion enzyme Cas3 is then specifically recruited to the Cascade/R-loop site to processively degrade long-stretches of double-stranded DNA nearby. I will give a comprehensive explanation of CRISPR-Cas3 based interference mechanism, based on the high-resolution biochemistry and structural biology work from my lab. I will further explain CRISPR-Cas3 based genome editing applications, and give perspectives on its therapeutic potential.

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Lecture / Discussion Wed, 25 Sep 2019 10:55:45 -0400 2019-10-14T16:00:00-04:00 2019-10-14T17:00:00-04:00 Palmer Commons Center for RNA Biomedicine Lecture / Discussion flyer
Cholesterol and Phospholipis Metabolism in Physiology and Disease- Annual William E.M. Lands Lectureship in Biological Chemistry (October 15, 2019 12:00pm) https://events.umich.edu/event/67920 67920-16966900@events.umich.edu Event Begins: Tuesday, October 15, 2019 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Peter Tontonoz will deliver the 15th annual William E.M. Lands Lecture on the Biochemical Basis for the Physiology of Essential Nutrients. Dr. Tontonoz is a Professor of Pathology and Laboratory Medicine at the University of California, Los Angeles.

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Lecture / Discussion Wed, 02 Oct 2019 10:37:58 -0400 2019-10-15T12:00:00-04:00 2019-10-15T13:00:00-04:00 Medical Science Unit II Biological Chemistry Lecture / Discussion Tontonoz
NO EEB Tuesday Lunch Seminar today (October 15, 2019 12:00pm) https://events.umich.edu/event/65000 65000-16501299@events.umich.edu Event Begins: Tuesday, October 15, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Have a good fall study break. See you next week!

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Workshop / Seminar Thu, 05 Sep 2019 16:32:06 -0400 2019-10-15T12:00:00-04:00 2019-10-15T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Biological Sciences Building background, UM EEB logo and text reading EEB Tuesday Lunch Seminars
How Cell Communication Drives Tissue Form and Function (October 16, 2019 9:30am) https://events.umich.edu/event/67426 67426-16849184@events.umich.edu Event Begins: Wednesday, October 16, 2019 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

2019 Cell & Developmental Biology Seminar Series

Hosted By: Pierre Coulombe, PhD & Kristen Verhey, PhD

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Lecture / Discussion Wed, 18 Sep 2019 15:33:41 -0400 2019-10-16T09:30:00-04:00 2019-10-16T10:30:00-04:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion CDB Seminar - Green
Department of Computational Medicine & Bioinformatics Weekly Seminar (October 16, 2019 4:00pm) https://events.umich.edu/event/68138 68138-17011980@events.umich.edu Event Begins: Wednesday, October 16, 2019 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Talk Title: "3D genome structure as a tool to understand the impact of somatic and germline sequence variants"

Abstract: The 3-dimensional organization of DNA inside of the nucleus impacts a variety of cellular processes, including gene regulation. Furthermore, it is apparent that somatic structural variants that affect how chromatin is organized in 3D can have a major impact on gene regulation and human disease. However, such structural variants in the context of cancer genomes are abundant, and predicting the consequence of any individual somatic mutation on 3D genome structure and gene expression is challenging. In addition, we are severely limited with regard to tools that can be used to study 3D folding of the genome in vivo in actual human tumor or tissue samples. Our lab has developed several approaches to address these challenges. We have taken a pan-cancer approach to identify loci in the genome that are affected by structural variants that alter 3D genome structure, and we have identified numerous loci with recurrent 3D genome altering mutations. We have also used genome engineering to create novel structural variants to better understand what types of mutations are actually capable of altering 3D genome structure and gene regulation. Finally, we have also developed novel tools to study 3D genome structure in vivo in complex tissue samples. We believe that these approaches will be critical for improving our understanding of how non-coding sequence variants can affect 3D genome structure and gene regulation, with the ultimate goal of understanding how these events affect human physiology.

3:45 pm - Light Refreshments Served
4:00 pm - Lecture

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Lecture / Discussion Mon, 07 Oct 2019 16:39:45 -0400 2019-10-16T16:00:00-04:00 2019-10-16T17:00:00-04:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
EEB Thursday Seminar: Who plants mate with, how they do it, and why it matters (October 17, 2019 4:00pm) https://events.umich.edu/event/65473 65473-16603599@events.umich.edu Event Begins: Thursday, October 17, 2019 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Biological diversity at all scales—ranging from patterns of nucleotide variation across chromosomes to phenotypic variation found within and between species—is shaped by the events of birth, movement, mating, and death that play out across populations for generations. Throughout each of these processes, the question of mate choice is crucially important. For example, every instance of mating with oneself (self-fertilization or selfing) halves an individual’s genomic variation, exposing rare recessive mutations. At the other end of the spectrum, mating with another species may either reduce fitness via hybrid incompatibilities or introduce novel, potentially adaptive, genetic variation. I present my research, which combines theory, and data to investigate both the evolutionary implications of these mating decisions (e.g. their effects on the species range, the nature of genetic variation, genomic architecture etc) and when and how such traits can (or cannot) evolve.

View YouTube video of seminar: https://youtu.be/w7GGngxIysU

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Workshop / Seminar Thu, 02 Apr 2020 12:53:20 -0400 2019-10-17T16:00:00-04:00 2019-10-17T17:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Yaniv Brandvain talk
The Community of Food, Society, and Justice Conference (October 18, 2019 8:00am) https://events.umich.edu/event/63979 63979-16051362@events.umich.edu Event Begins: Friday, October 18, 2019 8:00am
Location: East Quadrangle
Organized By: Residential College

The ways that we meet the nutritional needs of our communities, while also protecting the planet, promoting healthy lives, and ensuring food justice are among the greatest challenges facing our Nation and the world today. Centuries of unsustainable agricultural practices and inequitable food distribution place our food systems in peril. How to address these challenges and feed a hungry population raise transformative issues for our communities and academics committed to sustainability and food justice throughout the world.

The Community of Food, Society & Justice Conference will engage students, faculty, staff, farmers, and the community in rigorous dialogue around these challenges. The conference will be structured around a foundation of interdisciplinary scholarship that agrees that recognizing structural relations of power are necessary in order to confront race, class, and gender privileges on issues such as food justice.

Our keynote speaker is investigative reporter, Tracie McMillan, traciemcmillan.com, author of The American Way of Eating: Undercover at Walmart, Applebee’s, Farm Fields and the Dinner Table, and “The New Face of Hunger”.

>> CONFERENCE SCHEDULE >>
Friday, October 18:
8:00 am Registration table in EQ Upper Atrium
8:00 am Continental Breakfast EQ Private Dining Room

8:45 am Welcome, Keene Theater
Virginia Murphy, Faculty Director, Residential College East Quad Garden, University of Michigan

9:00- 10:15 am Panel 1: Soil Resistance and Recovery: How Academic Institutions Learn from Farmers
Panel Chair: Jeremy Moghtader, Manager, Campus Farm University of Michigan

> Jennifer Blesh, PhD (Assistant Professor, Soil and Agroecosystems, University of Michigan School for Environment and Sustainability)
> Tom Zilke (Co-Owner and Operator Zilke Vegetable Farm, and Zilke Farm Kitchen)
> Akello Karamoko (Farmer, Plum Street Market for Keep Growing Detroit) (Invited)

10:30-11:45am Panel 2: Growing Heritage: Reclaiming Indigenous Seeds
Panel Chair: Lisa Young, Lecturer IV, Department of Anthropology
> Shiloh Maples (Program Manager for Food Sovereignty & Wellness Initiatives, American Indian Health & Family Services, Detroit)
> Susan Sekaqueptewa (Assistant Agent for the Federally Recognized Tribal Extension Program, Hopi Tribe and the University of Arizona)
> Jessika Greendeer (Seed Regeneration Manager, Dream of Wild Health

11:45-12:30 pm Complimentary Lunch in East Quad (registration required to receive lunch). Buffet Luncheon prepared by University of Michigan Sustainable Food Program with Food Grown by the University of Michigan Campus Farm!

12:30-1:15pm Student Posters & Research Session Book Sale & Signing

1:15 -2:15 Keynote Speaker: Tracie McMillan, Keene Theater

2:30 - 3:45pm Panel 3: Healthy Food Actionists: Lightning fast discussions about what’s working and why
Panel Chair: Lilly Fink Shapiro, MPH; Program Manager, University of Michigan Sustainable Food Systems Initiative, University of Michigan
> Janee Moore, Food Access Public Health Consultant, Michigan Department of Health and Human Services
> Markell Miller, Director of Community Food Programs at Food Gatherers
> Laura Vollmer, Policy Analyst at University of California, Nutrition Policy Institute

3:45 - 5:00pm Panel 4: Community Values: Supporting Local Producers
Panel Chair: Alex Bryan, Manager, Sustainable Food Program, University of Michigan; Co-Owner, Food Field, Detroit, Michigan
> Melvin Parson (Founder and Executive Director of We the People’s Growers Association, Ypsilanti, Michigan)
> Invited: John Vandermeer, PhD (Professor of Ecology and Evolutionary Biology, University of Michigan)
> Invited: Student associated with Maize and Blue Cupboard (on campus food pantry founded by students, now a funded university initiative)

5:00 -5:30pm Closing Remarks
Dilip Das, Assistant Vice Provost for Academic Affairs, University of Michigan

5:00 - 5:30 pm Student Poster & Research Sessions
Book sale & signing

>> REGISTRATION is free and required for the conference at the link below.

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Conference / Symposium Tue, 24 Sep 2019 12:40:30 -0400 2019-10-18T08:00:00-04:00 2019-10-18T17:30:00-04:00 East Quadrangle Residential College Conference / Symposium Conference banner
MCDB Seminar: Monoterpene Volatile Biosynthesis in Rose Scented Geranium (October 18, 2019 12:00pm) https://events.umich.edu/event/67356 67356-16839924@events.umich.edu Event Begins: Friday, October 18, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Eran Pichersky

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Workshop / Seminar Tue, 17 Sep 2019 16:19:55 -0400 2019-10-18T12:00:00-04:00 2019-10-18T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Glandular trichomes Pelargonium graveolens
2019 Borer Lecture: Laurie Goodyear, PhD (October 18, 2019 2:30pm) https://events.umich.edu/event/65756 65756-16654032@events.umich.edu Event Begins: Friday, October 18, 2019 2:30pm
Location: Brehm Tower
Organized By: School of Kinesiology

This year's Katarina T. Borer Lectureship in Exercise Endocrinology and Metabolism guest speaker is Laurie Goodyear, PhD, Professor of Medicine and Section Head, Joslin Diabetes Center, at Harvard Medical School. She will present "Why Moms and Dads Should Exercise: Molecular Discoveries of the Beneficial Effects of Parental Exercise on Offspring Health."

Friday, October 18, at 2:30pm
Brehm Tower, Oliphant-Marshall Auditorium (1st floor)
1000 Wall St., Ann Arbor, MI 48109
Reception to follow

RSVP at http://myumi.ch/errk2!

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Lecture / Discussion Mon, 26 Aug 2019 16:54:36 -0400 2019-10-18T14:30:00-04:00 2019-10-18T17:30:00-04:00 Brehm Tower School of Kinesiology Lecture / Discussion Borer Lectureship: Laurie Goodyear, PhD
Science Forum Demo: Counting Cells (October 19, 2019 11:00am) https://events.umich.edu/event/66397 66397-16734167@events.umich.edu Event Begins: Saturday, October 19, 2019 11:00am
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world around you in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

The human body is made of more than 37 trillion cells. Most of them need to be replaced every couple of months, weeks, or sometimes in the course of only a few days. Our cells grow and divide constantly to get this massive job done. But how do cells replicate themselves? How do things move in, out, and around the cell, and into new cells? Join us as we explore how our bodies carry out this massive process. We will learn about cell structure and division and observe cells up-close and in action! Funded by the National Science Foundation.

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Presentation Thu, 05 Sep 2019 12:02:34 -0400 2019-10-19T11:00:00-04:00 2019-10-19T11:20:00-04:00 Biological Sciences Building Museum of Natural History Presentation Biological Sciences Building
Science Forum Demo: Counting Cells (October 20, 2019 11:00am) https://events.umich.edu/event/66397 66397-16734171@events.umich.edu Event Begins: Sunday, October 20, 2019 11:00am
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world around you in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

The human body is made of more than 37 trillion cells. Most of them need to be replaced every couple of months, weeks, or sometimes in the course of only a few days. Our cells grow and divide constantly to get this massive job done. But how do cells replicate themselves? How do things move in, out, and around the cell, and into new cells? Join us as we explore how our bodies carry out this massive process. We will learn about cell structure and division and observe cells up-close and in action! Funded by the National Science Foundation.

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Presentation Thu, 05 Sep 2019 12:02:34 -0400 2019-10-20T11:00:00-04:00 2019-10-20T11:20:00-04:00 Biological Sciences Building Museum of Natural History Presentation Biological Sciences Building
Biodiversity Lab Chat (October 20, 2019 3:30pm) https://events.umich.edu/event/66426 66426-16736295@events.umich.edu Event Begins: Sunday, October 20, 2019 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the website or Welcome Desk for times.

Stop by and chat with an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world.

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Other Thu, 26 Sep 2019 12:44:56 -0400 2019-10-20T15:30:00-04:00 2019-10-20T15:45:00-04:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
Complex Systems - Quant. Bio Seminar | Stochastic Turing patterns in oceans, brains and biofilms (October 21, 2019 12:00pm) https://events.umich.edu/event/68409 68409-17080044@events.umich.edu Event Begins: Monday, October 21, 2019 12:00pm
Location: West Hall
Organized By: The Center for the Study of Complex Systems

A special seminar co-hosted by Quantitative Bio. Seminars & CSCS. The first of two talks Professor Goldenfeld will be giving in two days at the University of Michigan

ABSTRACT
Why are the patterns of plankton in the ocean so patchy? Why do frequently described geometrical hallucinations tend to fall into one of four different classes of pattern? Why don't we see hallucinations all the time? And why do populations in ecosystems tend to have noisy cycles in abundance? This talk explains how these phenomena all arise from the discreteness of the underlying entities, be they the on-off states of neurons or the numbers of bacteria in a fluid volume of ocean, or the number of signaling molecules in a biofilm. I explain how tools from statistical mechanics can yield insights into these phenomena, and report on a range of studies that include the operation of the primate visual cortex, the behavior of signalling molecules in a forward-engineered synthetic biofilm, and the fluctuating patterns and populations of marine organisms.

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Workshop / Seminar Tue, 15 Oct 2019 15:45:09 -0400 2019-10-21T12:00:00-04:00 2019-10-21T13:00:00-04:00 West Hall The Center for the Study of Complex Systems Workshop / Seminar Swanlund Professor of Physics Nigel Goldenfeld
RNA Innovation Seminar, Ruslan Afasizhev, Boston University Medical Campus (October 21, 2019 4:00pm) https://events.umich.edu/event/65138 65138-16539449@events.umich.edu Event Begins: Monday, October 21, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Ruslan Afasizhev, PhD, Professor, Molecular & Cell Biology, Boston University Medical Campus

Abstract: Parasitic protist Trypanosoma brucei causes African human and animal trypanosomiasis, a spectrum of diseases affecting the population and economy in sub-Saharan Africa. These digenetic hemoflagellates belong to Kinetoplastea, a taxonomic class distinguished by possession of a kinetoplast. This nucleoprotein body contains mitochondrial DNA of two kinds: ~25 maxicircles (each ~23kb) encoding ribosomal RNAs, two guide RNA (gRNAs), ribosomal proteins and subunits of respiratory complexes, and approximately 5000 of ~1kb minicircles bearing the majority of gRNA genes. Relaxed maxicircles and minicircles are interlinked and packed into a dense disc-shaped network by association with histone-like proteins. Both maxicircle and minicircle genomes are transcribed by a phage-like RNA polymerase from multiple promoters into 3′-extended precursors which undergo 3′-5′ exonucleolytic trimming. To function in mitochondrial translation, pre-mRNAs must further proceed through 3′ adenylation, and often gRNA-directed uridine insertion/deletion editing, and 3′ A/U-tailing. Ribosomal and guide RNAs are typically 3′ uridylated. Historically, the fascinating phenomenon of RNA editing has attracted major research efforts, but more recent developments provided insights into pre- and post-edited processing events and identified key players in transforming primary precursors into functional RNAs and regulating their turnover. I will present a forward-looking model that integrates known modalities of mitochondrial RNA metabolism.

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Lecture / Discussion Wed, 25 Sep 2019 10:59:39 -0400 2019-10-21T16:00:00-04:00 2019-10-21T17:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion flyer
Complex Systems Seminar | (Soft) Matter of Life and Death: Biophysical Consequences of Death and Reproduction in Bacterial Biofilms (October 22, 2019 11:30am) https://events.umich.edu/event/68311 68311-17045990@events.umich.edu Event Begins: Tuesday, October 22, 2019 11:30am
Location: Weiser Hall
Organized By: The Center for the Study of Complex Systems

Biofilms are surface attached communities formed by bacteria and other microbes. Biofilms that form in nature typically feature different taxa, species, and multiple strains of the same species. These cells compete for nutrients and space. Due to the broad prevalence of biofilms, bacteria have evolved various competitive strategies, many of which are antagonistic. This includes a number of complex toxin delivery systems, which kill competitors but not kin. Because biofilms are densely packed, cell death and reproduction hold emergent mechanical consequences. When a cell dies and lyses, the biofilm may partially ‘cave-in;’ when a cell reproduces, it pushes other cells out of its way. This deadly competition creates a feedback loop. Death and reproduction modify biofilm structure; structural changes impact subsequent death and reproduction. In this talk, I will explore the intertwined relationship between intercellular killing and biofilm materials properties, explaining both the new physics that arises and its biological impact.

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Workshop / Seminar Fri, 11 Oct 2019 14:48:50 -0400 2019-10-22T11:30:00-04:00 2019-10-22T13:00:00-04:00 Weiser Hall The Center for the Study of Complex Systems Workshop / Seminar Peter Yunker
EEB Tuesday Lunch Seminar: Phenotypic and genotypic changes in the evolution of antibiotic resistance after decades of relaxed selection (October 22, 2019 12:00pm) https://events.umich.edu/event/65001 65001-16501300@events.umich.edu Event Begins: Tuesday, October 22, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Please join us for our weekly brown bag lunch seminar.

Abstract
Populations often encounter environmental changes that remove selection for the maintenance of certain phenotypic traits. The resulting decay of these traits under relaxed selection reduces an organism’s fitness in its prior environment. However, how these traits subsequently evolve upon restoration of selection is not well-understood. We addressed this question using Escherichia coli strains from the long-term evolution experiment (LTEE) that have been independently evolving for multiple decades in the absence of antibiotics. We confirmed that these derived strains have typically become more sensitive to various antibiotics during this time. We then asked how readily the bacteria could overcome these losses of intrinsic resistance through subsequent evolution when challenged with these same drugs. In our study, we focused on the role that genetic background plays in this process, with attention to the tension between evolutionary repeatability and contingency. We found that idiosyncratic responses in evolvability dominated over trends of diminishing returns, such that the potential to evolve increased resistance was hampered on some derived genetic backgrounds. We further subjected a time-series of clones from one LTEE population to tetracycline and showed that evolutionary constraint occurred early in its history. Taken together, our results indicate that the evolution and diversification of a single species in an antibiotic-free environment can render resistance evolution unpredictable, even for closely related strains. Current work is now centered on characterizing the genomic changes underlying resistance to address whether the same genes are the focus of selection when strains have evolved for decades in the absence of antibiotics.

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Workshop / Seminar Tue, 15 Oct 2019 11:47:45 -0400 2019-10-22T12:00:00-04:00 2019-10-22T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar petri dishes with colorful filter effect
Prediction Error & Model Evaluation for Space-Time Downscaling: case studies in air pollution during wildfires (October 22, 2019 1:00pm) https://events.umich.edu/event/68191 68191-17026797@events.umich.edu Event Begins: Tuesday, October 22, 2019 1:00pm
Location: Public Health I (Vaughan Building)
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

ABSTRACT:
Public Health Scientists use prediction models to downscale (i.e., interpolate) air pollution exposure where monitoring data is insufficient. This exercise aims to obtain estimates at fine resolutions, so that exposure data may reliably be related to health outcomes. In this setting, substantial research efforts have been dedicated to the development of statistical models capable of integrating heterogenous information to obtain accurate prediction: statistical downscaling models, land use regression, as well as machine learning strategies. However, when presented with the tasks of choosing between models, or averaging models, we find that our understanding of model performance in the absence of independent statistical replications remains insufficient. This lecture is motivated by several studies of air pollution (PM 2.5 and ground-level ozone) during wildfires. We review the basis for cross validation as a strategy for the estimation of the expected prediction error. As these performance measure play a crucial role in model selection and averaging we present a formal characterization of the estimands targeted by different data subsetting strategies, and explore their performance in engineered data settings. A final analysis and a warning about preference inversion is presented in relation to the a 2008 wildfire event in Northern California.

BIO:
Dr. Telesca is Associate Professor of Biostatistics at the University of California Los Angeles. He received a Ph.D. in Statistics from the University of Washington and spent two years at the University of Texas M.D. Anderson Cancer Center as a postdoctoral fellow. His research interests include Bayesian methods in multivariate statistics, functional data analysis, statistical methods in bio- and nano-informatics. Dr. Telesca is a member of the California NanoSystems Institute, the UCLA Jonsson Comprehensive Cancer Center and principal data scientist at Lucid Circuit Inc.

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Lecture / Discussion Wed, 09 Oct 2019 09:51:07 -0400 2019-10-22T13:00:00-04:00 2019-10-22T14:30:00-04:00 Public Health I (Vaughan Building) Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Donatello Telesca Environmental Statistics Day Lecture
Pizza with Professors (October 22, 2019 4:00pm) https://events.umich.edu/event/68522 68522-17094824@events.umich.edu Event Begins: Tuesday, October 22, 2019 4:00pm
Location: Undergraduate Science Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Join faculty, graduate students, and fellow students for pizza and conversation! This will be an informal meeting for students to learn more about their major, research, and career opportunities in the field. Bring your questions for faculty and talk to other interested students!
Register using the web link below.

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Social / Informal Gathering Fri, 18 Oct 2019 09:15:10 -0400 2019-10-22T16:00:00-04:00 2019-10-22T18:00:00-04:00 Undergraduate Science Building Department of Molecular, Cellular, and Developmental Biology Social / Informal Gathering graphic of pizza and info on the event
Pizza with Professors (October 22, 2019 4:00pm) https://events.umich.edu/event/68576 68576-17103242@events.umich.edu Event Begins: Tuesday, October 22, 2019 4:00pm
Location: Undergraduate Science Building
Organized By: Program in Biology

The Departments of Molecular, Cellular, and Developmental Biology (MCDB) and Ecology and Evolutionary Biology (EEB) invite you to Pizza with Professors! This is an informal time to chat with MCDB and EEB professors about research, courses, and pre-professional studies over a slice of pizza!

Please RSVP here: https://forms.gle/hzpEbWV4SZfpfrkf6

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Careers / Jobs Fri, 18 Oct 2019 09:54:44 -0400 2019-10-22T16:00:00-04:00 2019-10-22T18:00:00-04:00 Undergraduate Science Building Program in Biology Careers / Jobs Join us for Pizza with Professors!
CDB Seminar: Torsin and other nuclear envelope proteins: Structural biology on a roller coaster (October 23, 2019 4:00pm) https://events.umich.edu/event/67428 67428-16849200@events.umich.edu Event Begins: Wednesday, October 23, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

2019 Cell & Developmental Biology Seminar Series

Hosted By: Kristen Verhey, PhD

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Lecture / Discussion Mon, 28 Oct 2019 15:52:52 -0400 2019-10-23T16:00:00-04:00 2019-10-23T17:00:00-04:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion CDB Seminar - Schwartz
Department of Computational Medicine & Bioinformatics Weekly Seminar Series (October 23, 2019 4:00pm) https://events.umich.edu/event/68168 68168-17020453@events.umich.edu Event Begins: Wednesday, October 23, 2019 4:00pm
Location:
Organized By: DCMB Seminar Series

Talk Title: "Chromatin accessibility signatures of immune system aging"

Abstract: Aging is linked to deficiencies in immune responses and increased systemic inflammation. To unravel regulatory programs behind these changes, we profiled peripheral blood mononuclear cells (PBMCs) from young and old individuals (n=77) using ATAC-seq and RNA-seq technologies and analyzed these data via systems immunology tools. First, we described an epigenomic signature of immune system aging, with simultaneous systematic chromatin closing at promoters and enhancers associated with T cell signaling. This signature was primarily borne by memory CD8+ T cells, which exhibited an aging-related loss in IL7R activity and IL7 responsiveness. More recently to uncover the impact of sex on immune system aging, we studied PBMCs from 194 healthy adults (100 women, 94 men) ranging from 22-93 years old using ATAC-seq, RNA-seq, and flow cytometry technologies. These data revealed a shared epigenomic signature of aging between sexes composed of declines in naïve T cell functions and increases in monocyte and cytotoxic cell functions. Despite similarities, these changes were greater in magnitude in men. Additionally, we uncovered male-specific decreases in expression/accessibility of B-cell associated loci. Trajectory analyses revealed that age-related epigenomic changes were more abrupt at two timepoints in the human lifespan. The first timepoint was similar between sexes in terms of timing (early forties) and magnitude. In contrast, the latter timepoint was earlier (~5 years) and more pronounced in men (mid-sixties versus late-sixties). Unexpectedly, differences between men and women PBMCs increased with aging, with men having higher monocyte and pro-inflammatory activity and lower B/T cell activity compared to women after 65 years of age. Our study uncovered which immune cell functions and molecules are differentially affected with age between sexes, including the differences in timing and magnitude of changes, which is an important step towards precision medicine in older adults.

3:45 pm - Light refreshments served
4:00 pm - Lecture

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Lecture / Discussion Tue, 08 Oct 2019 15:12:18 -0400 2019-10-23T16:00:00-04:00 2019-10-23T17:00:00-04:00 DCMB Seminar Series Lecture / Discussion
Science, Technology, and Public Policy Graduate Certificate Info Session (October 23, 2019 4:00pm) https://events.umich.edu/event/67933 67933-16969022@events.umich.edu Event Begins: Wednesday, October 23, 2019 4:00pm
Location: Weill Hall (Ford School)
Organized By: Science, Technology, and Public Policy (STPP) Program

Join us for an information session about the Science, Technology, and Public Policy (STPP) Graduate Certificate!

Wednesday, October 23rd, 4:00pm-5:00pm
5240 Weill Hall
There will be SNACKS!

Do you want to learn how science and technology policy is made? Are you interested in the social and ethical implications of developments like gene editing and autonomous vehicles? Are you concerned about the increased politicization of science and research funding?

In the STPP graduate certificate program, graduate students from across the University analyze the role of science and technology in the policymaking process, gain experience writing for policymakers, and explore the political and policy landscape of areas such as biotechnology, information technology, energy, and others. Graduates of the STPP certificate have gone on to a range of policy-engaged scientific roles in government, NGOs, and academia.

More information about the program is available at: http://stpp.fordschool.umich.edu/graduate-certificate/

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Presentation Wed, 02 Oct 2019 13:21:49 -0400 2019-10-23T16:00:00-04:00 2019-10-23T17:00:00-04:00 Weill Hall (Ford School) Science, Technology, and Public Policy (STPP) Program Presentation Information Session promotional slide
BME Seminar: Jason Papin, Ph.D. (October 24, 2019 9:00am) https://events.umich.edu/event/68620 68620-17105386@events.umich.edu Event Begins: Thursday, October 24, 2019 9:00am
Location: Chrysler Center
Organized By: Biomedical Engineering

New experimental technologies to characterize microbes result in voluminous data on the genotype-phenotype relationship under diverse conditions. Computer models have become indispensable tools to integrate such data and facilitate the generation and testing of hypotheses. We will discuss recent methods to construct and test computer models of microbial metabolism that are being used to identify novel drug targets and characterize the evolution of antibiotic resistance.

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Lecture / Discussion Fri, 18 Oct 2019 15:23:24 -0400 2019-10-24T09:00:00-04:00 2019-10-24T10:00:00-04:00 Chrysler Center Biomedical Engineering Lecture / Discussion BME Logo
MedChem Seminar (October 24, 2019 1:00pm) https://events.umich.edu/event/68815 68815-17155485@events.umich.edu Event Begins: Thursday, October 24, 2019 1:00pm
Location:
Organized By: Department of Medicinal Chemistry

Trimming the C-terminal tail of alpha-tubulin: What is it good for?

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Lecture / Discussion Thu, 24 Oct 2019 13:36:22 -0400 2019-10-24T13:00:00-04:00 2019-10-24T14:00:00-04:00 Department of Medicinal Chemistry Lecture / Discussion
MedChem Seminar (October 24, 2019 1:00pm) https://events.umich.edu/event/68815 68815-17155486@events.umich.edu Event Begins: Thursday, October 24, 2019 1:00pm
Location:
Organized By: Department of Medicinal Chemistry

Trimming the C-terminal tail of alpha-tubulin: What is it good for?

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Lecture / Discussion Thu, 24 Oct 2019 13:36:22 -0400 2019-10-24T13:00:00-04:00 2019-10-24T14:00:00-04:00 Department of Medicinal Chemistry Lecture / Discussion
MedChem Seminar (October 24, 2019 1:00pm) https://events.umich.edu/event/68815 68815-17155487@events.umich.edu Event Begins: Thursday, October 24, 2019 1:00pm
Location:
Organized By: Department of Medicinal Chemistry

Trimming the C-terminal tail of alpha-tubulin: What is it good for?

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Lecture / Discussion Thu, 24 Oct 2019 13:36:22 -0400 2019-10-24T13:00:00-04:00 2019-10-24T14:00:00-04:00 Department of Medicinal Chemistry Lecture / Discussion
EEB and the Institute for Global Change Biology Thursday Seminar: The long-term climate change mitigation potential of working lands (October 24, 2019 4:00pm) https://events.umich.edu/event/65474 65474-16605608@events.umich.edu Event Begins: Thursday, October 24, 2019 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Land management has been proposed as a means to help lower greenhouse gas emissions and reduce atmospheric carbon dioxide (CO2) concentrations. Research in California has shown significant potential to lower methane emissions from waste management and subsequently increase short-term soil carbon (C) storage via amendments of composted organic material. However, effective climate change mitigation will require long-term or sustained emissions reduction and C sequestration. We used field experiments and modeling to explore the long-term potential of improved agricultural practices on greenhouse gas emissions and ecosystem C cycling. A decade following a one-time application of composted organic matter to grassland soils, amended plots accumulated approximately 9 Mg C ha-1 more soil C in the top 30 cm than paired controls. Aboveground plant growth was also higher in the amended plots after 10 years. Soil C stocks and C sequestration rates in compost-amended plots were resistant to rainfall and temperature changes predicted by Earth Systems Models (ESMs). We used two climate models (HadGEM and CanESM) and two climate change scenarios (RCP 4.5 and RCP 8.5) to determine the sensitivity of rangeland C dynamics to climate change with and without composted amendments to the year 2100. Drier sites yielded surprisingly high rates of C storage and were less sensitive to climate change than wetter sites. We also used a new micrometeorological approach to estimate greenhouse gas fluxes from composted manure, green waste, and food waste, the highest emitting organic waste streams. We found that manure and green waste had considerably lower methane emission factors than food waste, and that all composted wastes had lower emission factors with composting than with landfilling or slurrying. Our results show that there are alternative management approaches can both lower greenhouse gas emissions and sequester atmospheric CO2 over short and long time periods, and thus provide viable climate change mitigation approaches.

View YouTube video of seminar: https://youtu.be/0JjEXOx9mQ8

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Workshop / Seminar Thu, 02 Apr 2020 12:54:38 -0400 2019-10-24T16:00:00-04:00 2019-10-24T17:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar EEB Seminar Silver
LSA Bonderman Fellowship Info Session (October 25, 2019 12:00pm) https://events.umich.edu/event/68404 68404-17077942@events.umich.edu Event Begins: Friday, October 25, 2019 12:00pm
Location: Michigan League
Organized By: Center for Global and Intercultural Study

The Bonderman Fellowship offers 4 graduating University of Michigan LSA (Literature, Science and the Arts) seniors $20,000 to travel the world. They must travel to at least 6 countries in 2 regions over the course of 8 months and are expected to immerse themselves in independent and enriching explorations.

Come to a Bonderman information session to learn more about the fellowship and how to apply! Pizza will be provided!

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Presentation Fri, 18 Oct 2019 10:30:00 -0400 2019-10-25T12:00:00-04:00 2019-10-25T13:00:00-04:00 Michigan League Center for Global and Intercultural Study Presentation Fellow pictured abroad
MCDB Seminar: Telomerase RNA Biogenesis: Human Genetics to Therapeutic Prospects (October 25, 2019 12:00pm) https://events.umich.edu/event/67357 67357-16839925@events.umich.edu Event Begins: Friday, October 25, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: JK Nandakumar

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Workshop / Seminar Tue, 17 Sep 2019 16:28:46 -0400 2019-10-25T12:00:00-04:00 2019-10-25T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar micrograph of teleomeres
Science Forum Demo: Counting Cells (October 26, 2019 11:00am) https://events.umich.edu/event/66397 66397-16734168@events.umich.edu Event Begins: Saturday, October 26, 2019 11:00am
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world around you in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

The human body is made of more than 37 trillion cells. Most of them need to be replaced every couple of months, weeks, or sometimes in the course of only a few days. Our cells grow and divide constantly to get this massive job done. But how do cells replicate themselves? How do things move in, out, and around the cell, and into new cells? Join us as we explore how our bodies carry out this massive process. We will learn about cell structure and division and observe cells up-close and in action! Funded by the National Science Foundation.

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Presentation Thu, 05 Sep 2019 12:02:34 -0400 2019-10-26T11:00:00-04:00 2019-10-26T11:20:00-04:00 Biological Sciences Building Museum of Natural History Presentation Biological Sciences Building
Biodiversity Lab Chat (October 26, 2019 3:30pm) https://events.umich.edu/event/66426 66426-16736292@events.umich.edu Event Begins: Saturday, October 26, 2019 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the website or Welcome Desk for times.

Stop by and chat with an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world.

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Other Thu, 26 Sep 2019 12:44:56 -0400 2019-10-26T15:30:00-04:00 2019-10-26T15:45:00-04:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
Science Forum Demo: Counting Cells (October 27, 2019 11:00am) https://events.umich.edu/event/66397 66397-16734172@events.umich.edu Event Begins: Sunday, October 27, 2019 11:00am
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world around you in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

The human body is made of more than 37 trillion cells. Most of them need to be replaced every couple of months, weeks, or sometimes in the course of only a few days. Our cells grow and divide constantly to get this massive job done. But how do cells replicate themselves? How do things move in, out, and around the cell, and into new cells? Join us as we explore how our bodies carry out this massive process. We will learn about cell structure and division and observe cells up-close and in action! Funded by the National Science Foundation.

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Presentation Thu, 05 Sep 2019 12:02:34 -0400 2019-10-27T11:00:00-04:00 2019-10-27T11:20:00-04:00 Biological Sciences Building Museum of Natural History Presentation Biological Sciences Building
Biodiversity Lab Chat (October 27, 2019 3:30pm) https://events.umich.edu/event/66426 66426-16736296@events.umich.edu Event Begins: Sunday, October 27, 2019 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the website or Welcome Desk for times.

Stop by and chat with an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world.

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Other Thu, 26 Sep 2019 12:44:56 -0400 2019-10-27T15:30:00-04:00 2019-10-27T15:45:00-04:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
RNA Innovation Seminar, Luis Batista, Washington University in St. Louis (October 28, 2019 4:00pm) https://events.umich.edu/event/65140 65140-16539450@events.umich.edu Event Begins: Monday, October 28, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Luis Batista, PhD, Assistant Professor of Medicine and Developmental Biology, Washington University in St. Louis

Abstract: The overarching goal of the Batista lab is to understand the regulation and function of telomerase in tissue fitness, disease, and cancer. The Batista laboratory uses genome-wide methods to uncover alterations that drive cellular failure upon critical telomerase dysfunction, using the targeted differentiation of human pluripotent stem cells to tissues of clinical relevance as a primary model. We combine in vitro biochemical and mechanistic studies with our ability to generate and differentiate pluripotent cells towards different fates to better understand the importance of correct ribonucleoprotein assembly and function in tissue fitness and to determine the events that lead from impaired RNA-protein assembly to disease in humans.

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Lecture / Discussion Wed, 25 Sep 2019 11:00:45 -0400 2019-10-28T16:00:00-04:00 2019-10-28T17:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion flyer
CDB Dissertation Defense: Ye Li (October 29, 2019 10:00am) https://events.umich.edu/event/68769 68769-17147156@events.umich.edu Event Begins: Tuesday, October 29, 2019 10:00am
Location: Medical Science Research Building 2
Organized By: Cell & Developmental Biology

“Exploring neuronal heterogeneity in the Drosophila nervous system with novel neurotechnologies.”

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Lecture / Discussion Wed, 23 Oct 2019 13:20:35 -0400 2019-10-29T10:00:00-04:00 2019-10-29T11:00:00-04:00 Medical Science Research Building 2 Cell & Developmental Biology Lecture / Discussion Ye Li Dissertation Seminar
EEB Tuesday Lunch Seminar: The ecosystem consequences of wildfire activity over space and time: a field station perspective (October 29, 2019 12:00pm) https://events.umich.edu/event/65002 65002-16501301@events.umich.edu Event Begins: Tuesday, October 29, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Recent changes in ecosystem properties highlight major uncertainties about how disturbances will interact with ongoing climate change. Shifting fire regimes may lead to long-lasting directional changes or shifts in biogeochemical states, potentially impacting carbon and nitrogen balance over large spatial and temporal scales. However, data have been lacking to test these ideas over longer timescales – and to consider their implications for future projections – until only recently. A network of paleoecological records will document the role of climate in past fire-regime variability, and the potential for changing biogeochemical impacts will be evaluated. Combined with inferences from ecosystem and Earth system models, these results characterize how disturbances shape biogeochemical dynamics across a range of spatial and temporal scales. The important role of biological stations in catalyzing cutting-edge research, education, and outreach will also be explored.

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Workshop / Seminar Mon, 28 Oct 2019 11:24:40 -0400 2019-10-29T12:00:00-04:00 2019-10-29T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Ecosystem Wildfire - McLauchlan
Organelle Relationships in Aging and Disease- Department of Biological Chemistry Seminar (October 29, 2019 12:00pm) https://events.umich.edu/event/67925 67925-16966906@events.umich.edu Event Begins: Tuesday, October 29, 2019 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Adam Hughes, Assistant Professor of Biochemistry at the University of Utah, will be delivering the Department of Biological Chemistry Seminar.

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Film Screening Wed, 02 Oct 2019 11:03:08 -0400 2019-10-29T12:00:00-04:00 2019-10-29T13:00:00-04:00 Medical Science Unit II Biological Chemistry Film Screening Hughes
9th Annual Thomas D. Gelehrter M.D. Lecture in Medical Genetics (October 29, 2019 2:00pm) https://events.umich.edu/event/65874 65874-16662158@events.umich.edu Event Begins: Tuesday, October 29, 2019 2:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Department of Human Genetics

Helen H. Hobbs, M.D., is an Investigator of the Howard Hughes Medical Institute and a Professor of Internal Medicine and Molecular Genetics at the University of Texas Southwestern Medical Center. Among Dr. Hobbs’ honors was her election to the National Academy of Medicine in 2004 and National Academy of Sciences in 2007. She received the Breakthrough Prize in Life Sciences and Passano Award (with Jonathan Cohen) in 2016 and the Harrington Prize for Innovation in Medicine in 2018. Dr. Hobbs is recognized for her contributions to the development of new lipid-lowering strategies by identifying genetic variants of large effect in humans. Importantly, her work created a new strategy using human genetics to identify new therapeutic targets for the treatment of complex cardiovascular and metabolic disorders.

This lecture honors Thomas D. Gelehrter, M.D., active emeritus professor and former Chair of the Department of Human Genetics at the University of Michigan.

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Lecture / Discussion Tue, 27 Aug 2019 16:59:30 -0400 2019-10-29T14:00:00-04:00 2019-10-29T17:00:00-04:00 Taubman Biomedical Science Research Building Department of Human Genetics Lecture / Discussion Dr. Helen H. Hobbs
CDB Seminar - Cargo Receptors in the ER: From Clotting Factors to Cholesterol Regulation (October 30, 2019 9:30am) https://events.umich.edu/event/67430 67430-16849214@events.umich.edu Event Begins: Wednesday, October 30, 2019 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

2019 Cell & Developmental Biology Seminar Series

Hosted By: Doug Engel, PhD

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Lecture / Discussion Mon, 28 Oct 2019 15:55:29 -0400 2019-10-30T09:30:00-04:00 2019-10-30T10:30:00-04:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion CDB Seminar - Ginsburg
BME Seminar: Raj Kothapalli, Ph.D. (October 31, 2019 9:00am) https://events.umich.edu/event/68891 68891-17188750@events.umich.edu Event Begins: Thursday, October 31, 2019 9:00am
Location: Chrysler Center
Organized By: Biomedical Engineering

Photoacoustic imaging (PAI) gained significant attention of biomedical community as it provides optical
absorption contrast based functional and molecular information of very deep biological tissue at ultrasonic
resolution. In the last two decades, PAI evolved as a multi-scale imaging technology, enabling in vivo imaging from organelles to organs, and translated to several clinical applications such as breast and thyroid imaging. Nevertheless, the development of PAI systems for internal organs (e.g., prostate and ovaries) in the clinic has its challenges. In the first part of my talk, I will present the development of a transrectal ultrasound and photoacoustic (TRUSPA) human prostate imaging system, and its validation in various phantoms, surgically removed human prostates, in vivo mouse models of prostate cancer, all the way to the first-in-human multispectral photoacoustic human prostate imaging results. In the second part of my talk, I will introduce some new research developments in my lab. This includes results from a multimodal thermoacoustic simulation platform, novel ultrasound transducers for high throughput and wearable
photoacoustic imaging, and low-cost portable photoacoustic imaging systems.

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Lecture / Discussion Mon, 28 Oct 2019 15:51:53 -0400 2019-10-31T09:00:00-04:00 2019-10-31T10:00:00-04:00 Chrysler Center Biomedical Engineering Lecture / Discussion BME Logo
EEB Thursday Seminar: Unraveling the tangled web: the evolutionary impact of hybridization (October 31, 2019 4:00pm) https://events.umich.edu/event/65475 65475-16605609@events.umich.edu Event Begins: Thursday, October 31, 2019 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

How distinct species persist in the face of gene flow is a long-standing and central question in evolutionary biology, reinvigorated by the recent realization that hybridization is surprisingly common. Though it is now appreciated that gene flow often occurs before, during, and after speciation, little about the evolutionary impact of hybridization is understood, from the ecological and behavioral forces driving hybridization to the ways in which selection acts on hybrid genomes. Our research addresses these questions using replicate, recently formed hybrid populations of swordtail fish. I will discuss work mapping the locations of hybrid incompatibilities and investigating the role of selection on these regions in hybrid genome evolution. I will also discuss our work investigating how selection on incompatibilities interacts with other genetic processes such as recombination. Together, this work highlights a set of mechanisms that shape hybridization on a population and genetic level.

View YouTube video of seminar: https://youtu.be/NX1wEe5CCzk

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Workshop / Seminar Fri, 10 Apr 2020 14:16:23 -0400 2019-10-31T16:00:00-04:00 2019-10-31T17:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Image of Hybrid Fish
EEB Seminar Series: Leveraging the power of place to explore, educate and predict how the natural world works now and in the future (November 1, 2019 12:00pm) https://events.umich.edu/event/68571 68571-17103237@events.umich.edu Event Begins: Friday, November 1, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Field stations provide platforms for transformative long-term and placed-based research as well as extraordinary opportunities for education and outreach. Dr. Classen will discuss her field station vision using some examples from her own work exploring ecosystem and global change ecology. Broadly, the Classen group explores how ecosystems function and how biotic and abiotic interactions influence patterns and processes within and among communities and ecosystems. Working across scales from the micro (soil food webs) to the macro (regional carbon fluxes) as well as across diverse terrestrial ecosystems (forests, meadows, bogs; tropics, arctic, temperate) the Classen lab uses a combination of observations, experiments, and models to answer ecological and global change questions

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Workshop / Seminar Tue, 29 Oct 2019 13:08:07 -0400 2019-11-01T12:00:00-04:00 2019-11-01T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Dr. Classen in the field
MCDB Seminar: UTI Pathogenesis, Host-Pathogen Interface, Antibiotic-sparing therapeutics (November 1, 2019 12:00pm) https://events.umich.edu/event/67348 67348-16839904@events.umich.edu Event Begins: Friday, November 1, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Matt Chapman

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Workshop / Seminar Tue, 17 Sep 2019 15:23:11 -0400 2019-11-01T12:00:00-04:00 2019-11-01T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar high resolution micrograph of pathogenic bacteria binding to tissue
Science Forum Demo- Life: How do we find it? (November 2, 2019 3:00pm) https://events.umich.edu/event/67860 67860-16960500@events.umich.edu Event Begins: Saturday, November 2, 2019 3:00pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

Saturdays and Sundays, 3:00 p.m.

Discover how scientists search for life on other planets. Explore the field of astrobiology and re-evaluate your definition of life. Observe a re-creation of an experiment from the Mars Viking Lander expedition, and learn about what kinds of planets might support life.

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Presentation Tue, 29 Oct 2019 13:34:02 -0400 2019-11-02T15:00:00-04:00 2019-11-02T15:20:00-04:00 Biological Sciences Building Museum of Natural History Presentation Biological Sciences Building
Biodiversity Lab Chat (November 2, 2019 3:30pm) https://events.umich.edu/event/67974 67974-16977481@events.umich.edu Event Begins: Saturday, November 2, 2019 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the website or Welcome Desk for times.

Stop by and chat with an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world.

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Other Tue, 29 Oct 2019 13:34:30 -0400 2019-11-02T15:30:00-04:00 2019-11-02T15:45:00-04:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
Science Forum Demo- Life: How do we find it? (November 3, 2019 3:00pm) https://events.umich.edu/event/67860 67860-16960515@events.umich.edu Event Begins: Sunday, November 3, 2019 3:00pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

Saturdays and Sundays, 3:00 p.m.

Discover how scientists search for life on other planets. Explore the field of astrobiology and re-evaluate your definition of life. Observe a re-creation of an experiment from the Mars Viking Lander expedition, and learn about what kinds of planets might support life.

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Presentation Tue, 29 Oct 2019 13:34:02 -0400 2019-11-03T15:00:00-05:00 2019-11-03T15:20:00-05:00 Biological Sciences Building Museum of Natural History Presentation Biological Sciences Building
Biodiversity Lab Chat (November 3, 2019 3:30pm) https://events.umich.edu/event/67974 67974-16977486@events.umich.edu Event Begins: Sunday, November 3, 2019 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the website or Welcome Desk for times.

Stop by and chat with an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world.

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Other Tue, 29 Oct 2019 13:34:30 -0400 2019-11-03T15:30:00-05:00 2019-11-03T15:45:00-05:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
EEB Tuesday Lunch Seminar: Using mechanistic experiments, macroecology, and the Michigan Biological Station to understand biodiversity in a changing world (November 5, 2019 12:00pm) https://events.umich.edu/event/65003 65003-16501302@events.umich.edu Event Begins: Tuesday, November 5, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Please join us for our weekly brown bag lunch seminar.

In this talk, I'll summarize our work aimed at understanding the factors that shape biodiversity, from m2 quadrats to the globe. In particular, I will highlight how our work blends macroecological approaches, physiological experiments in the lab, and experimental manipulations in the field, mostly on ants. My view is that this synthetic approach, across scales, is the best way to understand and predict how biodiversity responds to global change drivers. Field stations are perfect launching pads for this kind of research and for introducing students, across disparate disciplines, to biodiversity and the services and functions it provides. Field stations can also be hubs for interdisciplinary collaborations and provide opportunities to ask, and address, pressing and fundamental questions across fields. The UMBS has been both a launching pad and hub for decades and is poised for continued growth and success.

View YouTube video of seminar: https://youtu.be/ND2ttvGjZ7U

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Workshop / Seminar Thu, 02 Apr 2020 13:06:58 -0400 2019-11-05T12:00:00-05:00 2019-11-05T13:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Experimental manipulations in the field, mostly on ants.
Mechanisms of Ribosome-Associated Quality Control- Biological Chemistry Seminar (November 5, 2019 12:00pm) https://events.umich.edu/event/68247 68247-17035290@events.umich.edu Event Begins: Tuesday, November 5, 2019 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Sichen Shao, Assistant Professor of Cell Biology at Harvard Medical School, will deliver the weekly Department of Biological Chemistry Seminar on Tuesday November 5th, 2019. Please join us in North Lecture Hall, MS II for this seminar.

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Lecture / Discussion Thu, 10 Oct 2019 07:46:26 -0400 2019-11-05T12:00:00-05:00 2019-11-05T13:00:00-05:00 Medical Science Unit II Biological Chemistry Lecture / Discussion Sichen Shao
Genetics of Invasive Glioblastoma Cells (November 5, 2019 4:00pm) https://events.umich.edu/event/67119 67119-16803020@events.umich.edu Event Begins: Tuesday, November 5, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for Cell Plasticity and Organ Design

2019 – 2020 Center for Organogenesis Seminar Series
Faculty Host: Xing Fan, Ph.D.
For additional information contact: organogenesis@umich.edu

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Lecture / Discussion Fri, 13 Sep 2019 10:08:43 -0400 2019-11-05T16:00:00-05:00 2019-11-05T17:00:00-05:00 Taubman Biomedical Science Research Building Center for Cell Plasticity and Organ Design Lecture / Discussion Genetics of Invasive Glioblastoma Cells
LSA Bonderman Fellowship Info Session (November 5, 2019 5:00pm) https://events.umich.edu/event/68404 68404-17077943@events.umich.edu Event Begins: Tuesday, November 5, 2019 5:00pm
Location: Michigan League
Organized By: Center for Global and Intercultural Study

The Bonderman Fellowship offers 4 graduating University of Michigan LSA (Literature, Science and the Arts) seniors $20,000 to travel the world. They must travel to at least 6 countries in 2 regions over the course of 8 months and are expected to immerse themselves in independent and enriching explorations.

Come to a Bonderman information session to learn more about the fellowship and how to apply! Pizza will be provided!

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Presentation Fri, 18 Oct 2019 10:30:00 -0400 2019-11-05T17:00:00-05:00 2019-11-05T18:00:00-05:00 Michigan League Center for Global and Intercultural Study Presentation Fellow pictured abroad
Neuroscience/Pre-Health Walk-In Co-Advising Session (November 6, 2019 11:00am) https://events.umich.edu/event/69093 69093-17244686@events.umich.edu Event Begins: Wednesday, November 6, 2019 11:00am
Location: Undergraduate Science Building
Organized By: Program in Biology

Come have your questions about neuroscience or pre-health studies answered during our Walk-In Co-Advising Session! Advisors will be ready to answer your questions!

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Careers / Jobs Mon, 04 Nov 2019 12:32:28 -0500 2019-11-06T11:00:00-05:00 2019-11-06T13:00:00-05:00 Undergraduate Science Building Program in Biology Careers / Jobs
Ph.D. Defense: Dakota Crisp (November 6, 2019 2:00pm) https://events.umich.edu/event/68890 68890-17188749@events.umich.edu Event Begins: Wednesday, November 6, 2019 2:00pm
Location: North Campus Research Complex Building 10
Organized By: Biomedical Engineering

Epilepsy is characterized by spontaneously recurring seizures that severely disrupt quality of life and pose risks of injury and death. It is a highly heterogenous disease, with seizures seen in a wide range of other diseases (Alzheimer’s, autism, Down’s syndrome, etc.). Yet to date, there is no method of categorizing seizures that can help distinguish the link between pathology and seizures. The aim of this work is to validate and explore a method of categorizing seizures based on their fundamental dynamics to provide a framework for future research to better investigate the underlying mechanisms of seizures and therapeutic approaches to stop them.

The first study used predictions from a previously-published computational model to visually classify seizures using dynamical transition features in two large datasets (simulated and real human data). Machine learning was applied to raw signal features to verify the accuracy of the reviewer’s labels. It found that visual classification is consistent and supported by the signal feature analysis. We also investigate the model’s predictions in real human data, finding that most dynamic classifications were observed and patients can have varying seizure dynamics over time. A major unpublished aspect of this work is that the human data analysis was crucial in the original development of the model.

The second study used data mining and machine learning in a long-term rat model of epileptogenesis to investigate the viability of these same dynamic principles as a biomarker of epileptic brain state. It also applied the same rigor to an analysis of the response to electrical stimulation. We found that evoked responses can be used to predict if an injured brain would eventually develop seizures or not. Once seizures began manifesting, both evoked responses and seizure onset dynamics had strong correlation with the progression of epileptogenesis, suggesting they are independent biomarkers.

For the final study, we use the same principles of dynamics and machine learning to characterize differences between a low Mg2+ / high K+ mouse brain-slice seizure model with and without different anti-seizure drugs. It found that anti-seizure drugs can change the observed seizure dynamics, and each drug has a different effect on brain dynamics.

These three studies provide evidence that seizures can be categorized by their fundamental dynamics. These dynamics can provide mechanistic insights into current brain state, future brain states, and the response to anti-epileptic drugs. The results presented in this dissertation can be used as a framework to further investigate seizure mechanisms and personalize patient treatment and research.

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Lecture / Discussion Mon, 28 Oct 2019 15:41:55 -0400 2019-11-06T14:00:00-05:00 2019-11-06T15:00:00-05:00 North Campus Research Complex Building 10 Biomedical Engineering Lecture / Discussion BME Logo
Department of Computational Medicine & Bioinformatics Weekly Seminar (November 6, 2019 4:00pm) https://events.umich.edu/event/68926 68926-17197024@events.umich.edu Event Begins: Wednesday, November 6, 2019 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract: Although central architectures drive robust oscillations, biological clock networks containing the same core vary drastically in their potential to oscillate. What peripheral structures contribute to the variation of oscillation behaviors remains elusive. We computationally generated an atlas of oscillators and found that, while certain core topologies are essential for robust oscillations, local structures substantially modulate the degree of robustness. Strikingly, two key local structures, incoherent inputs and coherent inputs, can modify a core topology to promote and attenuate its robustness, additively. These findings underscore the importance of local modifications besides robust cores, which explain why auxiliary structures not required for oscillation are evolutionarily conserved. We further apply this computational framework to search for structures underlying tunability, another crucial property shared by many biological timing systems to adapt their frequencies to environmental changes.

Experimentally, we developed an artificial cell system to reconstitute mitotic oscillatory processes in water-in-oil microemulsions. With a multi-inlet pressure-driven microfluidic setup, these artificial cells are flexibly adjustable in sizes, periods, various molecular and drug concentrations, energy, and subcellular compartments. Using long-term time-lapse fluorescence microscopy, this system enables high-throughput, single-cell analysis of clock dynamics, functions, and stochasticity, key to elucidating the topology-function relation of biological clocks.

We also investigate how multiple clocks coordinate via biochemical and mechanical signals in the essential developmental processes of early zebrafish embryos (e.g., mitotic wave propagation, synchronous embryo cleavages, and somitogenesis). To pin down the physical mechanisms that give rise to these complex collective phenomena, we integrate mathematical modeling, live embryo and explant imaging, nanofabrication, micro-contact printing, and systems and synthetic biology approaches.

BlueJeans livestream: https://primetime.bluejeans.com/a2m/live-event/rbuvycdc
Qiong Yang: https://medicine.umich.edu/dept/dcmb/qiong-yang-phd

3:45 pm to 4:00 pm - Light refreshments
4:00 pm - Lecture

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Lecture / Discussion Tue, 29 Oct 2019 12:56:42 -0400 2019-11-06T16:00:00-05:00 2019-11-06T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
BME Seminar: Michael Kolios, Ph.D. (November 7, 2019 9:00am) https://events.umich.edu/event/69110 69110-17244699@events.umich.edu Event Begins: Thursday, November 7, 2019 9:00am
Location: Chrysler Center
Organized By: Biomedical Engineering

Photoacoustic imaging relies on the generation of ultrasound waves from optically absorbing structures. The physics of photoacoustic wave generation has been compared to lightning and thunder. The interest in photoacoustic imaging has been steadily growing as optical contrast can be probed deeper in tissues compared to optical methods alone, resulting in possibly one of the most exciting new biomedical imaging techniques of the decade. Ultrasound waves produced by the absorption of light in tissue can be analyzed by methods similar to those developed to analyze ultrasound backscatter signals in the field known as ultrasound tissue characterization or quantitative ultrasound. The physics of photoacoustic wave generation can help in the interpretation of the signals detected by ultrasound transducers in photoacoustics. In the absence of exogenous optical absorbers, hemoglobin in red blood cells is the primary endogenous chromophore in tissues (as melanin is predominantly confined to the skin). The spatial distribution of red blood cells, typically confined to the vasculature, determines the frequency content of the ultrasound signals produced. Analysis of the photoacoustic signals can reveal information related to the tissue vasculature. We have applied these principles to cancer treatment monitoring and other blood pathologies. Tumor blood vessels have a distinct organizational structure compared to healthy blood vessels: typical
vessel networks are hierarchically organized, with vessels that are evenly distributed to ensure adequate oxygen and nutrient delivery. Tumor vessels are structurally different: they are torturous and typically hyperpermeable. Therapies that target the vasculature can induce changes in the vascular networks that, in principle, should be detected using photoacoustic imaging. In this presentation, we will review the techniques we have developed, which depend on the analysis of the frequency content of the ultrasound photoacoustic waves. We will show how we can use this information to filter vessels according to size with high specificity (resulting in a technique we have termed F-mode) and for non-resolvable vessels, how the frequency content of the photoacoustic signals encodes information about the size, concentration and spatial distribution of blood vessels. We also show how these techniques can be used to assess treatment response and speculate how we can use photoacoustic imaging to guide drug delivery and monitor its effects on tissues.

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Lecture / Discussion Mon, 04 Nov 2019 16:27:41 -0500 2019-11-07T09:00:00-05:00 2019-11-07T10:00:00-05:00 Chrysler Center Biomedical Engineering Lecture / Discussion BME Logo
EEB Thursday Seminar: Carnivores - competition and connectivity (November 7, 2019 4:00pm) https://events.umich.edu/event/65477 65477-16605610@events.umich.edu Event Begins: Thursday, November 7, 2019 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Current extinction rates are comparable to five prior mass extinctions in the earth’s history, and are strongly affected by human activities that have modified more than half of the earth’s terrestrial surface. Increasing human activity restricts animal movements and isolates formerly connected populations, a particular concern for the conservation of large carnivores, but no prior research has used high throughput sequencing in a standardized manner to examine genetic connectivity for multiple species of large carnivores and multiple ecosystems. We used RAD SNP genotypes to test for differences in connectivity between multiple ecosystems for African wild dogs (Lycaon pictus) and lions (Panthera leo), and to test correlations between genetic distance, geographic distance and landscape resistance due to human activity. We found weaker connectivity and a stronger correlation between genetic distance and landscape resistance for lions, and propose a new hypothesis that adaptations to interspecific competition may help to explain differences in vulnerability to isolation by humans.

View YouTube video of seminar: https://youtu.be/ekCd9EWl5G4

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Workshop / Seminar Fri, 10 Apr 2020 14:14:28 -0400 2019-11-07T16:00:00-05:00 2019-11-07T17:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Wild dog at sunset, EEB Seminar
FIRST: Future in Research, Science, and Teaching Q&A Panel with Life/Biomedical Science Professors (November 7, 2019 4:00pm) https://events.umich.edu/event/69000 69000-17211734@events.umich.edu Event Begins: Thursday, November 7, 2019 4:00pm
Location: Biological Sciences Building
Organized By: Program in Biology

Are you interested in attending graduate school? Becoming a professor? Running a research lab and teaching? Pursuing a MS or PhD-based career?

Join us for a Q&A panel with Professors Catherine Collins, Monica Dus, Jayakrishnan (JK) Nandakumar, Anthony Vechiarelli, who are faculty members in the Department of Molecular, Cellular, and Developmental Biology.

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Careers / Jobs Thu, 31 Oct 2019 10:15:11 -0400 2019-11-07T16:00:00-05:00 2019-11-07T17:00:00-05:00 Biological Sciences Building Program in Biology Careers / Jobs FIRST Q&A Panel
MedChem Seminar (November 7, 2019 4:00pm) https://events.umich.edu/event/68815 68815-17155484@events.umich.edu Event Begins: Thursday, November 7, 2019 4:00pm
Location: Pharmacy College
Organized By: Department of Medicinal Chemistry

Trimming the C-terminal tail of alpha-tubulin: What is it good for?

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Lecture / Discussion Thu, 24 Oct 2019 13:36:22 -0400 2019-11-07T16:00:00-05:00 2019-11-07T17:00:00-05:00 Pharmacy College Department of Medicinal Chemistry Lecture / Discussion Pharmacy College
EEB Seminar Series: Insights into the ecology and evolution of amphibian susceptibility to chytridiomycosis in a changing world AND a vision for the U of M Biological Station (November 8, 2019 12:00pm) https://events.umich.edu/event/68572 68572-17103239@events.umich.edu Event Begins: Friday, November 8, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

The amphibian chytrid fungus, Batrachochytrium dendrobatidis (Bd) is one of several emerging pathogens identified as key threats to wildlife. In some areas of the world the introduction of Bd to naïve host communities resulted in epidemics of the disease chytridiomycosis that caused numerous declines and extinctions. Our work in western Panama, which experienced die-offs in the mid-2000s, has focused on understanding what comes after such epidemics, testing hypotheses about the roles of host and pathogen evolution in the shift to endemic dynamics, or the persistence of host and pathogen in a shared environment. Another focus of my lab’s efforts has been on clarifying how both current (i.e., seasonal) and predicted future changes in climate shape the risk of disease related declines in North American frogs. Using a combination of field studies and experiments, we have begun to clarify the effect of temperature on host immune defenses and susceptibility to chytridiomycosis, and how the opportunity for thermally-mediated host defense varies in space and time. Using mesocosm studies, we are also investigating how climate-induced stress experienced during larval development impacts later life traits, like immune defense and thermal tolerance, that affect fitness in a broader context.
The University of Michigan Biological Station (UMBS) is a tremendous resource, with strengths in research, education and community engagement. Drawing on my experience as a field station researcher and director, I’ll conclude my seminar by outlining my vision for the future of the UMBS. Here I’ll highlight ways we can build upon the station’s existing strengths to promote more collaborative and interdisciplinary research, demonstrate excellence in place-based teaching and learning, and strengthen interactions between field station users and both the U of M and Northern Michigan communities.
Image by Ashley Cecil

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Workshop / Seminar Wed, 06 Nov 2019 11:14:47 -0500 2019-11-08T12:00:00-05:00 2019-11-08T13:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Zawacki ecology and evolution of amphibian susceptibility
MCDB Seminar: Cellular Pathways Regulating Early Pollen-Pistil Interactions and Self-Fertility (November 8, 2019 12:00pm) https://events.umich.edu/event/67360 67360-16839926@events.umich.edu Event Begins: Friday, November 8, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Cora MacAlister

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Workshop / Seminar Tue, 17 Sep 2019 16:38:38 -0400 2019-11-08T12:00:00-05:00 2019-11-08T13:00:00-05:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar close up photo of flower with parts labelled
Ph.D Defense: James R. Day (November 8, 2019 1:00pm) https://events.umich.edu/event/68888 68888-17188748@events.umich.edu Event Begins: Friday, November 8, 2019 1:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Biomedical Engineering

Cancer patient survivorship has increased substantially over the past few decades due to advances in anticancer treatments. However, a common deleterious effect of these lifesaving treatments is premature ovarian insufficiency (POI), as they are gonadotoxic. POI leads to infertility and loss of ovarian endocrine function, which is particularly devastating for female cancer survivors who experience POI prior to puberty, as puberty is the most crucial physiological event in a female’s life. Lack of ovarian endocrine function and absence of puberty leads to long-term co-morbidities such as poor bone health, diminished metabolic turnover, impacted cognition, and high risk of cardiovascular events. Current treatment options such as hormone replacement therapy and ovarian auto-transplantation are associated with non-physiological delivery of hormones and risk of re-implanting cancerous cells. This thesis details the work to prove our hypothesis that allo-transplantation of donor ovarian tissue can be utilized to restore ovarian endocrine function without evoking an immune response. We hypothesized the concept of immuno-isolation could be utilized to protect encapsulated allogeneic ovarian tissue in murine and non-human primate models.

First, we developed a dual poly(ethylene glycol) (PEG) that was appropriate for both ovarian tissue transplantation and immuno-isolation. The Dual PEG capsule contained a proteolytically degradable core crosslinked via Michael-type addition which was conducive for the dynamic growth of ovarian tissue and a non-degradable PEG shell that would serve as the immuno-protective barrier. We demonstrated in an ovariectomized syngeneic murine model that ovarian tissue encapsulated in Dual PEG survived and functioned until removed 60 days after implantation, which was shown through resumption of cyclicity, restoration of the hypothalamic-pituitary-gonadal (HPG) axis, and presence of healthy developed follicles.

Next, we demonstrated the capsule was immuno-isolating as allogeneic ovarian tissue encapsulated in Dual PEG and implanted in recipient mice did not evoke a significant allo-specific antibody response compared to controls and the capsule did not allow cellular infiltration; protecting the encapsulated allograft from the outside immune environment and leading to ovarian endocrine restoration. After we proved that the Dual PEG capsule can prevent cellular infiltration, we demonstrated that the capsule can also retain cells encapsulated within, which can possibly be applied towards ovarian tissue auto-transplantation through retention of cancerous cells present in the graft and preventing cancer spreading and metastasis. We then demonstrated that encapsulation of ovarian allografts in Dual PEG precludes sensitization of the host immune system which proves the capsule is immuno-isolating and the host immune system is not exposed to allo-antigens while the graft is encapsulating, possibly allowing multiple implantations of the capsule.

Lastly, we demonstrate that non-human primate ovarian tissue can survive and develop in the Dual PEG capsule restoring ovarian endocrine function, while being protected from an immune response as indicated by the lack of active, dividing T cells in a syngeneic and allogeneic NHP model. This proves the capsule can withstand the volumetric change present in NHP folliculogenesis, protecting the encapsulated allograft, which promotes graft survival and ovarian endocrine restoration. Taken together, this dissertation works towards allowing the implantation of allogeneic ovarian tissue to restore ovarian endocrine function in a physiological manner without the risk of immune rejection.

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Lecture / Discussion Mon, 28 Oct 2019 15:26:48 -0400 2019-11-08T13:00:00-05:00 2019-11-08T14:00:00-05:00 Taubman Biomedical Science Research Building Biomedical Engineering Lecture / Discussion BME Logo
MCDB Defense: Investigations of the Root Epidermal Cell Specification in Arabidopsis thaliana (November 11, 2019 1:30pm) https://events.umich.edu/event/69127 69127-17250862@events.umich.edu Event Begins: Monday, November 11, 2019 1:30pm
Location: Rackham Graduate School (Horace H.)
Organized By: Department of Molecular, Cellular, and Developmental Biology

Mentor: John Schielfelbein

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Workshop / Seminar Tue, 05 Nov 2019 11:52:54 -0500 2019-11-11T13:30:00-05:00 2019-11-11T15:30:00-05:00 Rackham Graduate School (Horace H.) Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar microscope images and MCDB
RNA Innovation Seminar, Bruce Sullenger, Duke School of Medicine (November 11, 2019 4:00pm) https://events.umich.edu/event/65141 65141-16539451@events.umich.edu Event Begins: Monday, November 11, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Bruce A. Sullenger, Ph.D.
Joseph and Dorothy Beard Professor
Department of Surgery
Professor of Pharmacology and Cancer Biology
Duke University Medical Center

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Lecture / Discussion Thu, 24 Oct 2019 08:30:39 -0400 2019-11-11T16:00:00-05:00 2019-11-11T17:00:00-05:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion flyer
EEB Tuesday Lunch Seminar/student evaluation: The biogeography of cichlids in the Guianas: insights into contemporary and historical drivers of diversity and endemism in Neotropical rivers (November 12, 2019 12:00pm) https://events.umich.edu/event/65004 65004-16501303@events.umich.edu Event Begins: Tuesday, November 12, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Please join us for our weekly brown bag lunch seminar

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Workshop / Seminar Tue, 05 Nov 2019 13:14:25 -0500 2019-11-12T12:00:00-05:00 2019-11-12T13:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Diagram showing map of South America, fish phylogenies
Hypoxia and Mitochondrial Disease: Can Two Wrongs Make a Right?- George William Jourdian Lectureship in Biological Chemistry (November 12, 2019 12:00pm) https://events.umich.edu/event/68289 68289-17043839@events.umich.edu Event Begins: Tuesday, November 12, 2019 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Vamsi Mootha, Professor of Systems Biology at Harvard Medical School and Professor of Medicine at Massachusetts General Hospital, will present the 3rd Annual George William Jourdian Lectureship in Biological Chemistry On Tuesday November 12th, 2019 at 12 noon in North Lecture Hall, MS II

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Lecture / Discussion Fri, 11 Oct 2019 08:37:52 -0400 2019-11-12T12:00:00-05:00 2019-11-12T13:00:00-05:00 Medical Science Unit II Biological Chemistry Lecture / Discussion Mootha
Student evaluation seminar: A tale of two dewlaps: the evolution of a colorful signal in Anolis lizards (November 12, 2019 3:00pm) https://events.umich.edu/event/68865 68865-17186663@events.umich.edu Event Begins: Tuesday, November 12, 2019 3:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

John David presents his preliminary seminar.

Image credit: John David Curlis

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Workshop / Seminar Mon, 28 Oct 2019 10:59:57 -0400 2019-11-12T15:00:00-05:00 2019-11-12T16:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Two anolis lizards on branches facing each other with yellow and white dewlaps extended, black background.
Genomic insights into human cortical development (November 12, 2019 4:00pm) https://events.umich.edu/event/68647 68647-17130514@events.umich.edu Event Begins: Tuesday, November 12, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for Cell Plasticity and Organ Design

2019-2020 Center for Organogenesis Seminar Series
Faculty Host(s): Jack Parent, Ken Kwan, Shigeki Iwase
For additional info contact: organogenesis@umich.edu

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Lecture / Discussion Mon, 21 Oct 2019 12:35:14 -0400 2019-11-12T16:00:00-05:00 2019-11-12T17:00:00-05:00 Taubman Biomedical Science Research Building Center for Cell Plasticity and Organ Design Lecture / Discussion Kriegstein Flyer
U-M Biological Station Prospective Student Information Session (November 12, 2019 4:00pm) https://events.umich.edu/event/65757 65757-16653999@events.umich.edu Event Begins: Tuesday, November 12, 2019 4:00pm
Location: Dana Natural Resources Building
Organized By: University of Michigan Biological Station

Prospective students: Come learn about how to earn credits, gain research experience, and have the spring/summer of your life at UMBS. Featuring a student panel, dates & deadlines, and financial aid information.

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Rally / Mass Meeting Mon, 26 Aug 2019 14:22:27 -0400 2019-11-12T16:00:00-05:00 2019-11-12T17:00:00-05:00 Dana Natural Resources Building University of Michigan Biological Station Rally / Mass Meeting Students enjoy a canoe ride on Douglas Lake at the U-M Biological Station.
CDB Seminar: Defining the role of ER-associated degradation in health and disease (November 13, 2019 9:30am) https://events.umich.edu/event/68707 68707-17138827@events.umich.edu Event Begins: Wednesday, November 13, 2019 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

2019 Cell & Developmental Biology Seminar Series

Hosted By: Qing Li, MD

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Lecture / Discussion Mon, 28 Oct 2019 15:56:34 -0400 2019-11-13T09:30:00-05:00 2019-11-13T10:30:00-05:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion CDB Seminar - Qi
Department of Computational Medicine & Bioinformatics Seminar (November 13, 2019 4:00pm) https://events.umich.edu/event/68641 68641-17128443@events.umich.edu Event Begins: Wednesday, November 13, 2019 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Talk Title: Reproducibility with high-dimensional data

Abstract: With the expanding generation of large-scale biological datasets, there has been an ever-greater concern in understanding the reproducibility of discoveries and findings in a statistically reliable manner. We review several concepts in reproducibility and describe how one can adopt a multiple testing perspective on the problem. This leads to an intuitive procedure for assessing reproducibility. We demonstrate application of the methodology using RNA-sequencing data as well as metabolomics datasets. We will also outline some further problems in the field.

This is joint work with Daisy Philtron, Yafei Lyu and Qunhua Li (Penn State) and Tusharkanti Ghosh, Weiming Zhang and Katerina Kechris (University of Colorado).

DCMB Faculty Host: Alla Karnovsky, PhD

3:45 p.m. - Light Refreshments
4:00 p.m. - Lecture

BlueJeans Live Streaming: https://primetime.bluejeans.com/a2m/live-event/rbuvycdc

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Lecture / Discussion Mon, 21 Oct 2019 11:05:22 -0400 2019-11-13T16:00:00-05:00 2019-11-13T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
EEB Thursday Seminar: The evolution of X-linked hybrid male sterility in Drosophila (November 14, 2019 4:00pm) https://events.umich.edu/event/67829 67829-16958325@events.umich.edu Event Begins: Thursday, November 14, 2019 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

During speciation, sex chromosomes accumulate interspecific genetic incompatibilities faster than the rest of the genome. As a consequence, X-linked hybrid sterility is often an early stage in the evolution of reproductive isolation. To understand why the X chromosome is a hotspot for the accumulation of hybrid sterility, we have undertaken genetic and population genomic analysis of X-linked hybrid male sterility between two fruit fly sister species, Drosophila mauritiana and D. simulans. We have identified multiple X-linked regions that are sufficient to cause male sterility when introgressed from D. mauritiana into a D. simulans genome. Spermatogenesis in sterile genotypes proceeds through meiosis but does not complete spermatid individualization. Most X-linked sterility results from incompatibly interactions with autosomal alleles, but both genetic and cytological results indicate that one factor causes sterility through interactions with the heterospecific Y chromosome. Previous theory suggests that X-linked sterilizing incompatibilities may arise through the evolution of sex chromosome meiotic drive elements. We find evidence that both supports and rejects this theory, as a known X-linked drive element recently migrated between these species and caused a strong reduction in local sequence divergence. Gene flow can therefore mediate the effects of selfish genetic elements during speciation.

View YouTube video of seminar: https://youtu.be/F0jiOjEsqa4

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Workshop / Seminar Thu, 02 Apr 2020 12:56:26 -0400 2019-11-14T16:00:00-05:00 2019-11-14T17:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Chromosomes and flies
MCDB Seminar: Maps and Neural Codes in Whisker Somatosensory Cortex (November 15, 2019 12:00pm) https://events.umich.edu/event/67361 67361-16839927@events.umich.edu Event Begins: Friday, November 15, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Sam Kwon

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Workshop / Seminar Tue, 17 Sep 2019 16:45:08 -0400 2019-11-15T12:00:00-05:00 2019-11-15T13:00:00-05:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar collage: rat whisker, micrograph, signals
Science Forum Demo- Life: How do we find it? (November 16, 2019 3:00pm) https://events.umich.edu/event/67860 67860-16960502@events.umich.edu Event Begins: Saturday, November 16, 2019 3:00pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

Saturdays and Sundays, 3:00 p.m.

Discover how scientists search for life on other planets. Explore the field of astrobiology and re-evaluate your definition of life. Observe a re-creation of an experiment from the Mars Viking Lander expedition, and learn about what kinds of planets might support life.

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Presentation Tue, 29 Oct 2019 13:34:02 -0400 2019-11-16T15:00:00-05:00 2019-11-16T15:20:00-05:00 Biological Sciences Building Museum of Natural History Presentation Biological Sciences Building
Biodiversity Lab Chat (November 16, 2019 3:30pm) https://events.umich.edu/event/67974 67974-16977483@events.umich.edu Event Begins: Saturday, November 16, 2019 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the website or Welcome Desk for times.

Stop by and chat with an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world.

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Other Tue, 29 Oct 2019 13:34:30 -0400 2019-11-16T15:30:00-05:00 2019-11-16T15:45:00-05:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
Science Forum Demo- Life: How do we find it? (November 17, 2019 3:00pm) https://events.umich.edu/event/67860 67860-16960517@events.umich.edu Event Begins: Sunday, November 17, 2019 3:00pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

Saturdays and Sundays, 3:00 p.m.

Discover how scientists search for life on other planets. Explore the field of astrobiology and re-evaluate your definition of life. Observe a re-creation of an experiment from the Mars Viking Lander expedition, and learn about what kinds of planets might support life.

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Presentation Tue, 29 Oct 2019 13:34:02 -0400 2019-11-17T15:00:00-05:00 2019-11-17T15:20:00-05:00 Biological Sciences Building Museum of Natural History Presentation Biological Sciences Building
Biodiversity Lab Chat (November 17, 2019 3:30pm) https://events.umich.edu/event/67974 67974-16977488@events.umich.edu Event Begins: Sunday, November 17, 2019 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the website or Welcome Desk for times.

Stop by and chat with an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world.

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Other Tue, 29 Oct 2019 13:34:30 -0400 2019-11-17T15:30:00-05:00 2019-11-17T15:45:00-05:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
BIONIC Lunch: Precision Health (November 19, 2019 12:00pm) https://events.umich.edu/event/63778 63778-15873596@events.umich.edu Event Begins: Tuesday, November 19, 2019 12:00pm
Location: North Campus Research Complex Building 10
Organized By: The Bioethics Discussion Group

Join us for a lunchtime discussion honing in on the ever truer you.

Please RSVP: https://forms.gle/Zxqo17yGh4PUB46cA

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Lecture / Discussion Mon, 23 Sep 2019 14:00:36 -0400 2019-11-19T12:00:00-05:00 2019-11-19T13:30:00-05:00 North Campus Research Complex Building 10 The Bioethics Discussion Group Lecture / Discussion Precision Health
EEB Tuesday Lunch Seminar: Fantastic biology instructors and where to find them (November 19, 2019 12:00pm) https://events.umich.edu/event/65005 65005-16501306@events.umich.edu Event Begins: Tuesday, November 19, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Please join us for our weekly brown bag lunch seminar.

Abstract
This Tuesday lunch seminar will cover results from multiple biology education research projects conducted at the University of Michigan. To better understand how the background of a Graduate Student Instructor (GSI) impacts student outcomes, we surveyed both GSIs and their undergraduate students in Introduction to Biology Lab. To assess the undergraduate Ecology, Evolution, and Biodiversity (EEB) major, we surveyed 42 seniors and found a discrepancy between general climate and inclusive practices. The seminar will conclude with suggested low-cost and meaningful changes we can make to improve inclusion in our EEB classes.

Image: Dale Austin

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Workshop / Seminar Wed, 13 Nov 2019 10:21:46 -0500 2019-11-19T12:00:00-05:00 2019-11-19T13:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar A graduate student instructor working with students measuring mammal specimens in BIO 173 lab
How to Make RNA Polymerase Processive- Department of Biological Chemistry Seminar (November 19, 2019 12:00pm) https://events.umich.edu/event/68248 68248-17035291@events.umich.edu Event Begins: Tuesday, November 19, 2019 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Irina Artsimovitch, Professor of Microbiology at Ohio State University, will be delivering the weekly Department of Biological Chemistry Seminar on Tuesday 11/19/19 at 12 noon in North Lecture Hall, MS II.

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Lecture / Discussion Thu, 10 Oct 2019 07:54:20 -0400 2019-11-19T12:00:00-05:00 2019-11-19T13:00:00-05:00 Medical Science Unit II Biological Chemistry Lecture / Discussion Artsimovitch
Modular Specification and Regeneration of Jaw Ligaments (November 19, 2019 4:00pm) https://events.umich.edu/event/67120 67120-16803021@events.umich.edu Event Begins: Tuesday, November 19, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for Cell Plasticity and Organ Design

2019 – 2020 Center for Organogenesis Seminar Series
Faculty Host: Kurt Hankenson
For additional information contact: organogenesis@umich.edu

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Lecture / Discussion Mon, 21 Oct 2019 12:15:16 -0400 2019-11-19T16:00:00-05:00 2019-11-19T17:00:00-05:00 Taubman Biomedical Science Research Building Center for Cell Plasticity and Organ Design Lecture / Discussion Crump Flyer
Dissonance Event Series: Protecting Patient Privacy in Big Data (November 19, 2019 6:00pm) https://events.umich.edu/event/69146 69146-17252912@events.umich.edu Event Begins: Tuesday, November 19, 2019 6:00pm
Location: Michigan League
Organized By: Information and Technology Services (ITS)

Join us on Tuesday, November 19, at 6 p.m., for an exciting Dissonance event: Protecting Patient Privacy in Big Data. This panel discussion will take place in the Vandenberg Room, on the second floor of the Michigan League on the UM-Ann Arbor campus. There is no charge for this event and no need to register.

Electronic health records, connected medical devices, health tracking applications, and more have led to a tidal wave of medical data. How this data is being used to transform patient care, improve care quality and decrease healthcare costs, however, is not always evident. Michigan Medicine physicians and legal scholars will explore how medical care will change as digital health platforms evolve, the legal ramifications we might have to navigate, and the privacy and ethical issues that are unfolding today.

- Dr. Brahmajee Nallamothu, Professor, Michigan Medicine (moderator)
- Dr. Jessica Golbus, House Officer, Michigan Medicine
- Prof. Nicholson Price, Professor, U-M Law School
- Dr. Hamid Ghanbari, Clinical Lecturer, Michigan Medicine
- Prof. Kayte Spector-Bagdady, Assistant Professor, U-M Medical School, Chief of the Research Ethics Service in the Center for Bioethics and Social Sciences in Medicine (CBSSM)
- Dr. Sachin Kheterpal, Associate Dean for Research Information Technology, Associate Professor, Michigan Medicine

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Lecture / Discussion Wed, 13 Nov 2019 11:29:44 -0500 2019-11-19T18:00:00-05:00 2019-11-19T19:15:00-05:00 Michigan League Information and Technology Services (ITS) Lecture / Discussion Dissonance Event: Protecting Patient Privacy in Big Data
Neuroscience Speaker Event (November 19, 2019 7:00pm) https://events.umich.edu/event/69290 69290-17299775@events.umich.edu Event Begins: Tuesday, November 19, 2019 7:00pm
Location: Mason Hall
Organized By: Huntington's Disease Awareness Association

A talk about Huntington's disease genetics, clinical signs and symptoms, limitations of current therapeutics, and exciting new developments in disease modification with ASOs and CRISPR technologies.

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Presentation Mon, 11 Nov 2019 09:48:32 -0500 2019-11-19T19:00:00-05:00 2019-11-19T20:00:00-05:00 Mason Hall Huntington's Disease Awareness Association Presentation HDAA at UMich
CDB Seminar: Microtubule drugs as medicine (November 20, 2019 9:30am) https://events.umich.edu/event/68705 68705-17138825@events.umich.edu Event Begins: Wednesday, November 20, 2019 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

2019 Cell & Developmental Biology Seminar Series

Hosted By: Ryoma Ohi, PhD & Kristen Verhey, PhD

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Lecture / Discussion Mon, 28 Oct 2019 15:57:49 -0400 2019-11-20T09:30:00-05:00 2019-11-20T10:30:00-05:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion CDB Seminar - Mitchison
DCMB Weekly Seminar (November 20, 2019 4:00pm) https://events.umich.edu/event/68972 68972-17205312@events.umich.edu Event Begins: Wednesday, November 20, 2019 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract: GWAS of neuropsychiatric diseases have identified many loci, however, causal variants often remain unknown. We performed ATAC-seq in human iPSC-derived neurons, and identified thousands of variants affecting chromatin accessibility. Such variants are highly enriched with risk variants of a range of brain disorders. We computationally fine-mapped causal variants and experimentally tested their activities using CRISPRi followed by single cell RNA-seq. Our work provides a framework for prioritizing noncoding disease variants.

The second part of my talk will be focused on genetics of N6-methyladenosine (m6A), a common form of mRNA modification. m6A plays an important role in regulating various aspects of mRNA metabolism in eukaryotes. However, little is known about how DNA sequence variations may affect the m6A modification and the role of m6A in common diseases. We mapped genetic variants associated with m6A levels in 60 Yoruba lymphoblast cell lines. By leveraging these variants, our analysis provides novel insights of mechanisms regulating m6A installation, and downstream effects of m6A on other molecular traits such as translation rate. Integrated analysis with GWAS data reveals m6A variation as an important mechanism linking genetic variations to complex diseases.

BlueJeans livestreaming link: https://primetime.bluejeans.com/a2m/live-event/rbuvycdc

3:45 p.m. - Light Refreshments
4:00 p.m. - Lecture

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Lecture / Discussion Wed, 30 Oct 2019 12:51:34 -0400 2019-11-20T16:00:00-05:00 2019-11-20T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
Complex Systems Seminar | The competitive exclusion principle in stochastic environments (November 21, 2019 11:30am) https://events.umich.edu/event/69158 69158-17254953@events.umich.edu Event Begins: Thursday, November 21, 2019 11:30am
Location: Weiser Hall
Organized By: The Center for the Study of Complex Systems

Abstract: The competitive exclusion principle states that a number of species competing for a smaller number of resources cannot coexist. Even though this is a fundamental principle in ecology, it has been observed empirically that in some settings it will fail. One example is Hutchinson's `paradox of the plankton'. This is an instance where a large number of phytoplankton species coexist while competing for a very limited number of resources. Both experimental and theoretical studies have shown that in some instances (deterministic) temporal fluctuations of the environment can facilitate coexistence for competing species. Hutchinson conjectured that one can get coexistence because non-equilibrium conditions would make it possible for different species to be favored by the environment at different times. In this talk I will look at how environmental noise interacts with competitive exclusion. I will show that, contrary to Hutchinson's explanation, one can switch between two environments in which the same species is favored and still get coexistence.

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Workshop / Seminar Wed, 06 Nov 2019 09:09:33 -0500 2019-11-21T11:30:00-05:00 2019-11-21T13:00:00-05:00 Weiser Hall The Center for the Study of Complex Systems Workshop / Seminar Alex Hening
LSA Bonderman Fellowship Info Session (November 21, 2019 12:00pm) https://events.umich.edu/event/68404 68404-17077944@events.umich.edu Event Begins: Thursday, November 21, 2019 12:00pm
Location: Palmer Commons
Organized By: Center for Global and Intercultural Study

The Bonderman Fellowship offers 4 graduating University of Michigan LSA (Literature, Science and the Arts) seniors $20,000 to travel the world. They must travel to at least 6 countries in 2 regions over the course of 8 months and are expected to immerse themselves in independent and enriching explorations.

Come to a Bonderman information session to learn more about the fellowship and how to apply! Pizza will be provided!

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Presentation Fri, 18 Oct 2019 10:30:00 -0400 2019-11-21T12:00:00-05:00 2019-11-21T13:00:00-05:00 Palmer Commons Center for Global and Intercultural Study Presentation Fellow pictured abroad
EEB Thursday Seminar: Do we need biodiversity for ecosystem services? (November 21, 2019 4:00pm) https://events.umich.edu/event/67830 67830-16958326@events.umich.edu Event Begins: Thursday, November 21, 2019 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

The importance of biodiversity to ecosystem functions such as biomass production and carbon storage is a key question in basic ecology, where it has been investigated largely through small-scale experiments and theory. It is also a key assumption in the conservation world that maintaining ecosystem services requires maintaining biodiversity. The role of biodiversity in ecosystem service provision in real-world landscapes is far from clear scientifically, however, in part because new conceptual approaches are required to even frame the question at these larger scales. In this talk I will discuss how my research program is tackling this problem.

View YouTube video of seminar: https://youtu.be/ortGYFbEWpo

Sponsored by the U-M Museum of Zoology Theodore H. Hubbell Memorial Lectureship

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Workshop / Seminar Thu, 02 Apr 2020 12:57:39 -0400 2019-11-21T16:00:00-05:00 2019-11-21T17:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Blueberry Habropoda image
MCDB: Probing Golgi Apparatus Organization a Rab at a Time (November 22, 2019 12:00pm) https://events.umich.edu/event/67362 67362-16839928@events.umich.edu Event Begins: Friday, November 22, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Yanzhuang Wang

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Workshop / Seminar Mon, 11 Nov 2019 15:31:00 -0500 2019-11-22T12:00:00-05:00 2019-11-22T13:00:00-05:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar micrograph of golgi apparatus
Science Forum Demo- Life: How do we find it? (November 23, 2019 3:00pm) https://events.umich.edu/event/67860 67860-16960503@events.umich.edu Event Begins: Saturday, November 23, 2019 3:00pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

Saturdays and Sundays, 3:00 p.m.

Discover how scientists search for life on other planets. Explore the field of astrobiology and re-evaluate your definition of life. Observe a re-creation of an experiment from the Mars Viking Lander expedition, and learn about what kinds of planets might support life.

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Presentation Tue, 29 Oct 2019 13:34:02 -0400 2019-11-23T15:00:00-05:00 2019-11-23T15:20:00-05:00 Biological Sciences Building Museum of Natural History Presentation Biological Sciences Building
Biodiversity Lab Chat (November 23, 2019 3:30pm) https://events.umich.edu/event/67974 67974-16977484@events.umich.edu Event Begins: Saturday, November 23, 2019 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the website or Welcome Desk for times.

Stop by and chat with an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world.

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Other Tue, 29 Oct 2019 13:34:30 -0400 2019-11-23T15:30:00-05:00 2019-11-23T15:45:00-05:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
Science Forum Demo- Life: How do we find it? (November 24, 2019 3:00pm) https://events.umich.edu/event/67860 67860-16960518@events.umich.edu Event Begins: Sunday, November 24, 2019 3:00pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

Saturdays and Sundays, 3:00 p.m.

Discover how scientists search for life on other planets. Explore the field of astrobiology and re-evaluate your definition of life. Observe a re-creation of an experiment from the Mars Viking Lander expedition, and learn about what kinds of planets might support life.

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Presentation Tue, 29 Oct 2019 13:34:02 -0400 2019-11-24T15:00:00-05:00 2019-11-24T15:20:00-05:00 Biological Sciences Building Museum of Natural History Presentation Biological Sciences Building
Biodiversity Lab Chat (November 24, 2019 3:30pm) https://events.umich.edu/event/67974 67974-16977489@events.umich.edu Event Begins: Sunday, November 24, 2019 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the website or Welcome Desk for times.

Stop by and chat with an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world.

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Other Tue, 29 Oct 2019 13:34:30 -0400 2019-11-24T15:30:00-05:00 2019-11-24T15:45:00-05:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
RNA Innovation Seminar, Kristian Baker, Case Western (November 25, 2019 4:00pm) https://events.umich.edu/event/65142 65142-16541442@events.umich.edu Event Begins: Monday, November 25, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Kristian E. Baker, Ph.D. (Principle Investigator), Center for RNA Molecular Biology, Case Western Reserve University

Abstract: The nonsense-mediated mRNA decay pathway in eukaryotes serves as an RNA quality control system to protect cells from persistent expression of C-terminally truncated polypeptides as a consequence of premature translation termination at nonsense codons. How the cell defines a translation termination event as premature and, subsequently, how this information is communicated to the decay machinery so as to accelerate the degradation of the mRNA remain unclear. We have previously shown that mutations within UPF1 - a member of the SF1 helicase superfamily and a core component of the NMD machinery - which inactivate its ATPase activity give rise to RNA decay intermediates that accumulate due to stalling of ribosomes at or near the premature termination codon. These findings revealed a key functional interaction between the translation apparatus and NMD machinery, and signify that ATP hydrolysis by UPF1 targets the ribosome to facilitate peptide hydrolysis and/or ribosome recycling during translation termination.
My lab’s ongoing efforts directed at dissecting the how UPF1 impacts premature translation termination will be presented.

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Lecture / Discussion Thu, 24 Oct 2019 12:52:12 -0400 2019-11-25T16:00:00-05:00 2019-11-25T17:00:00-05:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion flyer
EEB Tuesday Lunch Seminar: Pollinators, predators and parasitoids: the amazingly diverse world of Hymenoptera (November 26, 2019 12:00pm) https://events.umich.edu/event/65009 65009-16501307@events.umich.edu Event Begins: Tuesday, November 26, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Please join us for our weekly brown bag lunch seminar.

Abstract
Hymenoptera (bees, wasps, and ants) are some of the most numerous and diverse animals on the planet. The group includes pollinators, predators, parasitoids, herbivores and practically everything in-between. They can be found in almost every terrestrial habitat around the world (as well as a few aquatic ones) and many are essential in keeping food on our tables and pest populations under control, while others are pests themselves or are species of medical concern. Despite this insect group’s importance, and how integral it is in shaping the world we see today, there are still many fundamental unanswered questions about the taxa in this amazing group. This seminar will focus on Hymenoptera biodiversity and what the E. M. Tucker lab at the U-M Museum of Zoology is doing to explore unanswered questions about these extraordinary creatures.

Image courtesy of Sam Droege, USGS.

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Workshop / Seminar Wed, 20 Nov 2019 15:03:07 -0500 2019-11-26T12:00:00-05:00 2019-11-26T13:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Colorful images of 9 flies, wasps and ants showing diversity. Image courtesy of Sam Droege, USGS
RNA Innovation Seminar, Auinash Kalsotra, University of Illinois at Urbana-Champaign (December 2, 2019 4:00pm) https://events.umich.edu/event/65143 65143-16541443@events.umich.edu Event Begins: Monday, December 2, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Auinash Kalsotra, PhD, Associate Professor of Biochemistry, Affiliate, Institute for Genomic Biology, University of Illinois at Urbana-Champaign

Abstract: For many genes, steady-state messenger (m)RNA levels provide an inaccurate reflection of the extent to which they are translated into proteins. This seminar will focus on post-transcriptional mechanisms that affect the “quality” and “quantity” of RNAs produced in a cell-type- and context-dependent manner. First, I will describe the identification of a conserved developmentally regulated alternative splicing program that supports terminal differentiation, functional competence, and postnatal maturation of hepatocytes. Second, I will show evidence that following liver injury, this developmental splicing program is transiently re-activated to rewire a critical signaling pathway that enables proper liver regeneration. Third, I will demonstrate that in severe alcoholic hepatitis, the sustained re-activation of this developmental program causes hepatocytes to shed adult functions and become more regenerative but threatens overall survival by populating the liver with functionally-immature cells.

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Lecture / Discussion Thu, 24 Oct 2019 08:55:20 -0400 2019-12-02T16:00:00-05:00 2019-12-02T17:00:00-05:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion flyer
Biodiversity Lab Chat (December 3, 2019 12:00pm) https://events.umich.edu/event/69343 69343-17482933@events.umich.edu Event Begins: Tuesday, December 3, 2019 12:00pm
Location:
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the website or Welcome Desk for times.

Stop by and chat with an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world.

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Other Tue, 12 Nov 2019 12:44:15 -0500 2019-12-03T12:00:00-05:00 2019-12-03T13:00:00-05:00 Museum of Natural History Other
EEB Tuesday Lunch Seminar: Understanding the potential of wild populations to adapt to climate change: lessons from color molting mammals (December 3, 2019 12:00pm) https://events.umich.edu/event/65010 65010-16501308@events.umich.edu Event Begins: Tuesday, December 3, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Please join us for our weekly brown bag lunch seminar

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Workshop / Seminar Mon, 02 Dec 2019 14:57:03 -0500 2019-12-03T12:00:00-05:00 2019-12-03T13:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar A white rabbit amid grasses and plants
Department of Human Genetics 2019 Seminar Series (December 3, 2019 4:00pm) https://events.umich.edu/event/69796 69796-17425664@events.umich.edu Event Begins: Tuesday, December 3, 2019 4:00pm
Location: Buhl Res Cen for Human Genetics
Organized By: Department of Human Genetics

Dr. Dernburg will be presenting a seminar entitled, "Pairing and Patterning between Meiotic Chromosomes" on Tuesday, December 3, 2019 in the Buhl 5915 Classroom, 1241 Catherine Street, on the medical school campus. The seminar will begin at 4:00 pm, with light refreshments before the start of the seminar.

For more information, call 734-647-3149.






Presented by:





Abby Dernburg, Ph.D.
HHMI Investigator
Department of Molecular and Cell Biology
University of California, Berkeley





Tuesday, December 3, 2019
4:00-5:00 PM
5915 Buhl Classroom

Hosted by: Callie Swanepoel

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Lecture / Discussion Tue, 26 Nov 2019 14:19:16 -0500 2019-12-03T16:00:00-05:00 2019-12-03T17:00:00-05:00 Buhl Res Cen for Human Genetics Department of Human Genetics Lecture / Discussion Buhl Building, 1241 Catherine St.
Mechanisms and consequences of pancreatic cancer stromal evolution (December 3, 2019 4:00pm) https://events.umich.edu/event/68651 68651-17130518@events.umich.edu Event Begins: Tuesday, December 3, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for Cell Plasticity and Organ Design

2019-2020 Center for Organogenesis Seminar Series
Faculty Host(s): Mariana Pasca di Magliano and Howard Crawford
For additional info contact: organogenesis@umich.edu

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Lecture / Discussion Mon, 21 Oct 2019 12:44:53 -0400 2019-12-03T16:00:00-05:00 2019-12-03T17:00:00-05:00 Taubman Biomedical Science Research Building Center for Cell Plasticity and Organ Design Lecture / Discussion Sherman Flyer
LSA Bonderman Fellowship Info Session (December 4, 2019 5:00pm) https://events.umich.edu/event/68404 68404-17077945@events.umich.edu Event Begins: Wednesday, December 4, 2019 5:00pm
Location: Michigan League
Organized By: Center for Global and Intercultural Study

The Bonderman Fellowship offers 4 graduating University of Michigan LSA (Literature, Science and the Arts) seniors $20,000 to travel the world. They must travel to at least 6 countries in 2 regions over the course of 8 months and are expected to immerse themselves in independent and enriching explorations.

Come to a Bonderman information session to learn more about the fellowship and how to apply! Pizza will be provided!

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Presentation Fri, 18 Oct 2019 10:30:00 -0400 2019-12-04T17:00:00-05:00 2019-12-04T18:00:00-05:00 Michigan League Center for Global and Intercultural Study Presentation Fellow pictured abroad
Ph. D. Defense: Caymen Novak (December 5, 2019 10:00am) https://events.umich.edu/event/69802 69802-17425674@events.umich.edu Event Begins: Thursday, December 5, 2019 10:00am
Location: North Campus Research Complex Building 10
Organized By: Biomedical Engineering

Cells within the body experience a wide range of dynamic mechanical stimuli. These stimuli are exacerbated in cancers and can alter the progression of the disease. As the tumor grows and expands it displaces the surrounding matrix and cell environment creating internal compressive forces and altering interstitial and vascular blood flow thereby enhancing shear stress exposure. How the cells translate this mechano-environment into downstream signaling is known as mechanotransduction. Though preliminary research has touched on the influence physiological mechanical stimulus can have on cancer progression, the work remains erratic and lacks understanding of cell metastasis, gene expression, proliferation, and chemotherapeutic response. In order to address this unknown effect on cellular phenotypes and treatment response, two bioreactors capable of tunable three-dimensional stimulus with either shear stress or compressive forces were developed. Breast and ovarian cancer cells were exposed to physiological stimuli and studied for invasive potential, altered gene expression, proliferation, and chemotherapeutic response. Overall, findings suggest that this dynamic mechanical environment aids in the advancement of cancer migration, proliferation, and chemoresistance which may be mitigated by targeting of various mechanotransduction pathways. The bioreactors constructed and utilized for this study provide 3D platforms ideal for understanding the influence of compressive and shear stress stimulus on cellular behavior, a critical component to our understanding and improvement of cancer patient treatments.

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Lecture / Discussion Tue, 26 Nov 2019 15:14:47 -0500 2019-12-05T10:00:00-05:00 2019-12-05T11:00:00-05:00 North Campus Research Complex Building 10 Biomedical Engineering Lecture / Discussion BME Logo
Complex adaptive systems and human-wildlife coexistence (December 5, 2019 11:30am) https://events.umich.edu/event/69716 69716-17390846@events.umich.edu Event Begins: Thursday, December 5, 2019 11:30am
Location: Weiser Hall
Organized By: The Center for the Study of Complex Systems

Abstract:
In landscapes around the world, humans and wildlife are mutually adapting to each other, creating dynamic feedbacks that, if overlooked, limit the effectiveness of conservation policies. Mechanistic social-ecological systems (SES) modeling has a high potential to overcome this limitation. To illustrate the utility of mechanistic SES modeling to wildlife conservation, I present findings from two interrelated agent-based models of human-wildlife interactions. The first model investigates the effects of human disturbance (prey depletion, road infrastructure) on the globally endangered tiger (Panthera tigris) in an isolated protected area in Nepal. The second model investigates human-wildlife conflict, such as crop raiding and livestock depredation, along a simulated interface of wild and agricultural lands. Unanticipated model outcomes provide crucial insights on ways to improve conservation strategies in shared landscapes. By simulating both ecological processes and human decision making, multi-model approaches foster transferability of gained insights to other contexts and case studies that prevail in the Anthropocene.

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Workshop / Seminar Tue, 26 Nov 2019 13:04:46 -0500 2019-12-05T11:30:00-05:00 2019-12-05T13:00:00-05:00 Weiser Hall The Center for the Study of Complex Systems Workshop / Seminar Neil Carter, SEAS
EEB Thursday Seminar: Phenotypic plasticity, gene expression, and the biological response to climate change (December 5, 2019 4:00pm) https://events.umich.edu/event/68351 68351-17069160@events.umich.edu Event Begins: Thursday, December 5, 2019 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

The climate of the earth is becoming hotter and less predictable, and the fitness of organisms is increasingly linked to traits important for performance in a changing climate. Understanding the relative roles of phenotypic plasticity and evolutionary adaptation as responses to climate change is crucial, as phenotypic plasticity is more rapid than evolutionary adaptation, and can either facilitate or constrain evolutionary adaptation. Crucially, for certain taxa like tropical forest lizards, previous long-term climate stability of the tropics may have eroded both genetic variation and capacity for phenotypic plasticity necessary for survival under rapid environmental change. We are testing how denizens of tropical forests can respond to climate change by 1) studying physiological and phenotypic plasticity of a thermoconforming forest lizard, and 2) transplanting these lizards onto islands in the Panama Canal. These islands are hotter and more variable than the mainland rainforests of the source populations. On experimental islands, we are measuring selection (viability and fecundity) on thermal physiological traits, measuring plasticity and gene expression in response to thermal change, and identifying genomic regions that are important for thermal adaptation. Ultimately, our research can help parse the relative roles of phenotypic plasticity, genomic adaptation, and their interaction during the biological response to climate change.

View YouTube video of seminar: https://youtu.be/axBZDqu68EM

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Workshop / Seminar Thu, 02 Apr 2020 12:58:25 -0400 2019-12-05T16:00:00-05:00 2019-12-05T17:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Christian Cox, biological response to climate change
MCDB Seminar: In Toto Imaging in Zebrafish Shows How Cells 'Build' Patterns (December 6, 2019 12:00pm) https://events.umich.edu/event/67363 67363-16839929@events.umich.edu Event Begins: Friday, December 6, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Cunming Duan

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Workshop / Seminar Tue, 17 Sep 2019 17:08:59 -0400 2019-12-06T12:00:00-05:00 2019-12-06T13:00:00-05:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar digital image fish embryo
Science Forum Demo- Life: How do we find it? (December 7, 2019 3:00pm) https://events.umich.edu/event/69340 69340-17310083@events.umich.edu Event Begins: Saturday, December 7, 2019 3:00pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

Saturdays and Sundays, 3:00 p.m.

Discover how scientists search for life on other planets. Explore the field of astrobiology and re-evaluate your definition of life. Observe a re-creation of an experiment from the Mars Viking Lander expedition, and learn about what kinds of planets might support life.

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Presentation Tue, 12 Nov 2019 12:29:00 -0500 2019-12-07T15:00:00-05:00 2019-12-07T15:20:00-05:00 Biological Sciences Building Museum of Natural History Presentation Biological Sciences Building