Happening @ Michigan https://events.umich.edu/list/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. UROP Summer Research Fellowship Deadline Extended (December 9, 2019 7:00am) https://events.umich.edu/event/70080 70080-17507886@events.umich.edu Event Begins: Monday, December 9, 2019 7:00am
Location: Undergraduate Science Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2019-12-09T07:00:00-05:00 2019-12-09T23:59:00-05:00 Undergraduate Science Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
BME Coffee Hour (December 9, 2019 2:00pm) https://events.umich.edu/event/66337 66337-16727928@events.umich.edu Event Begins: Monday, December 9, 2019 2:00pm
Location: Lurie Biomedical Engineering
Organized By: Biomedical Engineering

All faculty, students, postdocs, and staff are encouraged to join in the upper atrium of LBME for snacks and coffee. This is a time to take a break and gather casually amongst your peers.

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Social / Informal Gathering Wed, 04 Sep 2019 15:06:20 -0400 2019-12-09T14:00:00-05:00 2019-12-09T15:00:00-05:00 Lurie Biomedical Engineering Biomedical Engineering Social / Informal Gathering BME Coffee Hour
UROP Summer Research Fellowship Deadline Extended (December 10, 2019 7:00am) https://events.umich.edu/event/70080 70080-17507887@events.umich.edu Event Begins: Tuesday, December 10, 2019 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2019-12-10T07:00:00-05:00 2019-12-10T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
Bioethics Discussion: Antinatalism (December 10, 2019 7:00pm) https://events.umich.edu/event/52723 52723-12974156@events.umich.edu Event Begins: Tuesday, December 10, 2019 7:00pm
Location: Lurie Biomedical Engineering
Organized By: The Bioethics Discussion Group

A discussion on the end to our means.

Readings to consider:
1. The Last Messiah
2. Why It Is Better Never to Come into Existence
3. Every Conceivable Harm: A Further Defence of Anti-Natalism
4. The Ethics of Procreation and Adoption

For more information and/or to receive a copy of the readings contact Barry Belmont at belmont@umich.edu or visit http://belmont.bme.umich.edu/bioethics-discussion-group/discussions/037-antinatalism/.

Tell your descendants to consider the blog: https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Tue, 13 Aug 2019 10:54:42 -0400 2019-12-10T19:00:00-05:00 2019-12-10T20:30:00-05:00 Lurie Biomedical Engineering The Bioethics Discussion Group Lecture / Discussion Antinatalism
UROP Summer Research Fellowship Deadline Extended (December 11, 2019 7:00am) https://events.umich.edu/event/70080 70080-17507888@events.umich.edu Event Begins: Wednesday, December 11, 2019 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2019-12-11T07:00:00-05:00 2019-12-11T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
BME Seminar: Alexandra Rutz (December 11, 2019 9:00am) https://events.umich.edu/event/69696 69696-17382664@events.umich.edu Event Begins: Wednesday, December 11, 2019 9:00am
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Remarkable advances in medicine and biology have been made possible with bioelectronics – devices that bridge and connect the worlds of living systems and electronics. Bioelectronics include wearable sensors for health monitoring, in vitro diagnostics, therapeutic implantable devices, and electrical stimulation for tissue engineering and regeneration. Despite their influence, bioelectronic devices are still limited by the fact that they are disparate and distinct from biology. The quality of the device-tissue interface is poor and diminishes with time; this is thought to be due to many factors including significant surgical trauma, an aggressive foreign body response, poor material compatibility with the biological milieu, as well as imprecise and distant connections between electronics and surrounding cells or tissues. Towards addressing these challenges, I will first present the use of slippery surfaces for mitigating the consequences of implanting bioelectronics into delicate tissues. I will demonstrate how liquid-infused elastomers reduce tissue deformation and tearing associated with the insertion of intracortical probes in rats. I will then present how, unlike typical electronic fabrication processes, additive manufacturing is compatible with biomaterials and cells. I will demonstrate that when “inks”, processing methods, and scaffold structure are engineered appropriately, extrusion-based 3D printing affords patterned, viable, and functional cell networks, and I will discuss how this can be exploited in future bioelectronic devices. To conclude, I will briefly present my vision to continue tackling the pressing challenges of biointegration that bioelectronics face in expanding their clinical and scientific impacts. The Rutz Lab will engineer “electronic tissues” that merge electronics and biology using additive manufacturing and biomaterials approaches.

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Lecture / Discussion Thu, 21 Nov 2019 10:42:20 -0500 2019-12-11T09:00:00-05:00 2019-12-11T10:00:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Lecture / Discussion BME Logo
UROP Summer Research Fellowship Deadline Extended (December 12, 2019 7:00am) https://events.umich.edu/event/70080 70080-17507889@events.umich.edu Event Begins: Thursday, December 12, 2019 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2019-12-12T07:00:00-05:00 2019-12-12T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
Learning Health Sciences Collaboratory Holiday Luncheon (December 12, 2019 12:00pm) https://events.umich.edu/event/69514 69514-17335463@events.umich.edu Event Begins: Thursday, December 12, 2019 12:00pm
Location: Michigan League
Organized By: Department of Learning Health Sciences

The Learning Health System (LHS) Collaboratory is a campus-wide hub for faculty, student and staff interest in LHS initiatives, advancing interdisciplinary research and promoting the development of learning health systems. To learn more about the Collaboratory, please visit: dlhs-umi.ch/lhs-collaboratory.

Join us on December 12th for our final event of 2019 as we get into the holiday spirit with the LHS Collaboratory! Enjoy food, friendship and some interesting updates at the LHS Collaboratory’s holiday luncheon and networking event. Feel free to bring a colleague (or two) who are new to the Collaboratory – the more the merrier! We welcome all members and their guests to celebrate the holiday season with the LHS Collaboratory! This will be an informal event with a short business meeting to bring everyone up to date on LHS developments across the country and around the world.

See you on the 12th!

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Lecture / Discussion Fri, 15 Nov 2019 13:34:25 -0500 2019-12-12T12:00:00-05:00 2019-12-12T13:30:00-05:00 Michigan League Department of Learning Health Sciences Lecture / Discussion Sign for Collaboratory
UROP Summer Research Fellowship Deadline Extended (December 13, 2019 7:00am) https://events.umich.edu/event/70080 70080-17507890@events.umich.edu Event Begins: Friday, December 13, 2019 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2019-12-13T07:00:00-05:00 2019-12-13T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (December 14, 2019 7:00am) https://events.umich.edu/event/70080 70080-17507891@events.umich.edu Event Begins: Saturday, December 14, 2019 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2019-12-14T07:00:00-05:00 2019-12-14T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (December 15, 2019 7:00am) https://events.umich.edu/event/70080 70080-17507892@events.umich.edu Event Begins: Sunday, December 15, 2019 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2019-12-15T07:00:00-05:00 2019-12-15T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (December 16, 2019 7:00am) https://events.umich.edu/event/70080 70080-17507893@events.umich.edu Event Begins: Monday, December 16, 2019 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2019-12-16T07:00:00-05:00 2019-12-16T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
BME Coffee Hour (December 16, 2019 2:00pm) https://events.umich.edu/event/66337 66337-16727929@events.umich.edu Event Begins: Monday, December 16, 2019 2:00pm
Location: Lurie Biomedical Engineering
Organized By: Biomedical Engineering

All faculty, students, postdocs, and staff are encouraged to join in the upper atrium of LBME for snacks and coffee. This is a time to take a break and gather casually amongst your peers.

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Social / Informal Gathering Wed, 04 Sep 2019 15:06:20 -0400 2019-12-16T14:00:00-05:00 2019-12-16T15:00:00-05:00 Lurie Biomedical Engineering Biomedical Engineering Social / Informal Gathering BME Coffee Hour
UROP Summer Research Fellowship Deadline Extended (December 17, 2019 7:00am) https://events.umich.edu/event/70080 70080-17507894@events.umich.edu Event Begins: Tuesday, December 17, 2019 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2019-12-17T07:00:00-05:00 2019-12-17T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
BIONIC Lunch: Death Positivity (December 17, 2019 12:00pm) https://events.umich.edu/event/63779 63779-15873597@events.umich.edu Event Begins: Tuesday, December 17, 2019 12:00pm
Location: North Campus Research Complex Building 10
Organized By: The Bioethics Discussion Group

Join us for a lunchtime discussion in the mere hours we have remaining.

Please RSVP: https://forms.gle/HK2mP7nMLiB6L9w3A

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Lecture / Discussion Mon, 23 Sep 2019 14:01:00 -0400 2019-12-17T12:00:00-05:00 2019-12-17T13:30:00-05:00 North Campus Research Complex Building 10 The Bioethics Discussion Group Lecture / Discussion Death Positivity
UROP Summer Research Fellowship Deadline Extended (December 18, 2019 7:00am) https://events.umich.edu/event/70080 70080-17507895@events.umich.edu Event Begins: Wednesday, December 18, 2019 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2019-12-18T07:00:00-05:00 2019-12-18T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (December 19, 2019 7:00am) https://events.umich.edu/event/70080 70080-17507896@events.umich.edu Event Begins: Thursday, December 19, 2019 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2019-12-19T07:00:00-05:00 2019-12-19T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
BME Ph.D. Defense: Amos Cao (December 19, 2019 10:00am) https://events.umich.edu/event/70078 70078-17507831@events.umich.edu Event Begins: Thursday, December 19, 2019 10:00am
Location: Lurie Robert H. Engin. Ctr
Organized By: Biomedical Engineering

Functional magnetic resonance imaging (fMRI) is a neuroimaging technique that provides an unparalleled ability to non-invasive study brain activity. Since its inception in the early 1990s, fMRI has become a dominant tool in studying neurological responses to tasks and stimuli and has been critical in our evolving understanding of brain mapping. These achievements in neuroscience would not be possible without critical breakthroughs in MRI theory and hardware advancements, which continue to increase the speed and resolution of fMRI acquisitions. This dissertation explores a highly signal efficient fMRI imaging strategy known as Oscillating Steady-State Imaging (OSSI) and presents specialized artifact compensation strategies for addressing the practical challenges of the OSSI method.

First, we develop analytical models and simulations of OSSI, which describe how the signal magnitude varies as a function of frequency. These simulations are then used to study how respiration-induced frequency changes cause artifactual signal fluctuations to a signal timecourse. Our simulations show that the severity of respiration artifacts changes with initial off-resonance. Furthermore, we show that respiration artifacts are primarily caused by transient signal effects rather than changes to steady-state magnitude. These findings inform the two correction strategies proposed in the remainder of the dissertation.

The second portion of this work describes "OSSCOR," a retrospective method to correct timecourse magnitude changes caused by temporally varying frequency. We show how the OSSI signal exhibits a frequency-time duality that can be used to reshape structured physiological noise into a low-rank matrix. We then use principal component analysis in a data-driven correction strategy to create nuisance regressors for subsequent fMRI analysis. We also describe a variation of our method where free induction decay (FID) signals can be used to create nuisance regressors, referred to as ``F-OSSCOR.'' Both OSSCOR and F-OSSCOR were found to significantly improve the functional sensitivity and signal stability compared to polynomial detrending alone, and OSSCOR was also found to significantly outperform a standard data-driven correction method.

Finally, we present a prospective correction method which utilizes FID measurements to estimate and correct for B0 changes in real-time. Prospective correction has the potential to outperform retrospective correction methods by directly reducing perturbations to steady-state magnetization during acquisition. We first present the results of a feasibility analysis where simulation was used to determine how scan parameters would affect correction performance. We then developed a prospective correction application using the RTHawk platform to perform data analysis and parameter adjustment in real-time. Our initial fMRI proof-of-concept shows that real-time correction can increase the number of activated voxels and improve overall image stability as measured by temporal SNR.

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Workshop / Seminar Fri, 06 Dec 2019 13:00:13 -0500 2019-12-19T10:00:00-05:00 2019-12-19T10:00:00-05:00 Lurie Robert H. Engin. Ctr Biomedical Engineering Workshop / Seminar BME Event
UROP Summer Research Fellowship Deadline Extended (December 20, 2019 7:00am) https://events.umich.edu/event/70080 70080-17507897@events.umich.edu Event Begins: Friday, December 20, 2019 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2019-12-20T07:00:00-05:00 2019-12-20T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (December 21, 2019 7:00am) https://events.umich.edu/event/70080 70080-17507898@events.umich.edu Event Begins: Saturday, December 21, 2019 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2019-12-21T07:00:00-05:00 2019-12-21T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (December 22, 2019 7:00am) https://events.umich.edu/event/70080 70080-17507899@events.umich.edu Event Begins: Sunday, December 22, 2019 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2019-12-22T07:00:00-05:00 2019-12-22T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (December 23, 2019 7:00am) https://events.umich.edu/event/70080 70080-17507900@events.umich.edu Event Begins: Monday, December 23, 2019 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2019-12-23T07:00:00-05:00 2019-12-23T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (December 24, 2019 7:00am) https://events.umich.edu/event/70080 70080-17507901@events.umich.edu Event Begins: Tuesday, December 24, 2019 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2019-12-24T07:00:00-05:00 2019-12-24T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (December 25, 2019 7:00am) https://events.umich.edu/event/70080 70080-17507902@events.umich.edu Event Begins: Wednesday, December 25, 2019 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2019-12-25T07:00:00-05:00 2019-12-25T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (December 26, 2019 7:00am) https://events.umich.edu/event/70080 70080-17507903@events.umich.edu Event Begins: Thursday, December 26, 2019 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2019-12-26T07:00:00-05:00 2019-12-26T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (December 27, 2019 7:00am) https://events.umich.edu/event/70080 70080-17507904@events.umich.edu Event Begins: Friday, December 27, 2019 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2019-12-27T07:00:00-05:00 2019-12-27T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (December 28, 2019 7:00am) https://events.umich.edu/event/70080 70080-17507905@events.umich.edu Event Begins: Saturday, December 28, 2019 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2019-12-28T07:00:00-05:00 2019-12-28T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (December 29, 2019 7:00am) https://events.umich.edu/event/70080 70080-17507906@events.umich.edu Event Begins: Sunday, December 29, 2019 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2019-12-29T07:00:00-05:00 2019-12-29T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (December 30, 2019 7:00am) https://events.umich.edu/event/70080 70080-17507907@events.umich.edu Event Begins: Monday, December 30, 2019 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2019-12-30T07:00:00-05:00 2019-12-30T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (December 31, 2019 7:00am) https://events.umich.edu/event/70080 70080-17507908@events.umich.edu Event Begins: Tuesday, December 31, 2019 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2019-12-31T07:00:00-05:00 2019-12-31T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (January 1, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507909@events.umich.edu Event Begins: Wednesday, January 1, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-01-01T07:00:00-05:00 2020-01-01T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (January 2, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507910@events.umich.edu Event Begins: Thursday, January 2, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-01-02T07:00:00-05:00 2020-01-02T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (January 3, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507911@events.umich.edu Event Begins: Friday, January 3, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-01-03T07:00:00-05:00 2020-01-03T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (January 4, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507912@events.umich.edu Event Begins: Saturday, January 4, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-01-04T07:00:00-05:00 2020-01-04T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (January 5, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507913@events.umich.edu Event Begins: Sunday, January 5, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-01-05T07:00:00-05:00 2020-01-05T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (January 6, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507914@events.umich.edu Event Begins: Monday, January 6, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-01-06T07:00:00-05:00 2020-01-06T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (January 7, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507915@events.umich.edu Event Begins: Tuesday, January 7, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-01-07T07:00:00-05:00 2020-01-07T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
Guest Seminar: Ritu Raman, Ph.D., MIT (January 7, 2020 9:00am) https://events.umich.edu/event/70692 70692-17619578@events.umich.edu Event Begins: Tuesday, January 7, 2020 9:00am
Location: Industrial and Operations Engineering Building
Organized By: Biomedical Engineering

Biological materials dynamically sense and adapt their form and function to changing environments, but these capabilities have not been fully replicated in the synthetic materials traditionally used by engineers. My research has shown that integrating biohybrid and biomimetic materials with engineered systems yields devices capable of complex behaviors such as self-assembly, self-maintenance, and self-healing. These responsive behaviors are especially desirable in machines that interface with the dynamic human body, as they enable sensing and responding to individualized patient needs. This talk will cover my fundamental research in the field of biohybrid design, including: 1) Forward engineering of skeletal muscle bioactuators for adaptive biohybrid machines; 2) Design and implementation of smart responsive materials in implantable devices; 3) Micro-invasive tools for understanding cell-cell communication in complex 3D networks. These advances will enable my future lab to develop neuromuscular bioactuators for restoring motility in diseased or damaged bodily systems and actuating implantable devices. This talk will make the case that the next generation of biologically relevant machines must integrate our dynamic natural world with our own adaptive bodies.

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Workshop / Seminar Fri, 20 Dec 2019 13:41:59 -0500 2020-01-07T09:00:00-05:00 2020-01-07T10:00:00-05:00 Industrial and Operations Engineering Building Biomedical Engineering Workshop / Seminar U-M BME Event
UROP Summer Research Fellowship Deadline Extended (January 8, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507916@events.umich.edu Event Begins: Wednesday, January 8, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-01-08T07:00:00-05:00 2020-01-08T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (January 9, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507917@events.umich.edu Event Begins: Thursday, January 9, 2020 7:00am
Location: Undergraduate Science Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-01-09T07:00:00-05:00 2020-01-09T23:59:00-05:00 Undergraduate Science Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
EnginFest (January 9, 2020 2:00pm) https://events.umich.edu/event/70605 70605-17611201@events.umich.edu Event Begins: Thursday, January 9, 2020 2:00pm
Location: Duderstadt Center
Organized By: Engineering Student Government

Join Engineering Student Government for our first even winter student org fair, EnginFest! Learn more about your favorite engineering student organization and how to join them this semester.

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Fair / Festival Thu, 19 Dec 2019 12:09:41 -0500 2020-01-09T14:00:00-05:00 2020-01-09T17:00:00-05:00 Duderstadt Center Engineering Student Government Fair / Festival ESG EnginFest Banner
BME 500: Kent Leach, Ph.D. (January 9, 2020 4:00pm) https://events.umich.edu/event/70064 70064-17505686@events.umich.edu Event Begins: Thursday, January 9, 2020 4:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Advances in early detection of disease and increases in lifespan necessitate new strategies to repair or replace damaged organs and tissues. My research is directed toward incorporating cues from the native environment and natural extracellular matrix (ECM) into the design of cell culture platforms and musculoskeletal tissue engineered constructs. By applying fundamental principles in cell and molecular biology, biomaterials, and biotransport phenomena, we are developing materials-based strategies to direct the behavior of transplanted or host cells within bone defects and interrogate the behavior of various cell populations in more physiologically relevant conditions. In this talk, I will present examples of our recent work in designing biomaterials from cells and natural and synthetic polymers to instruct cell fate and enhance tissue formation and function with applications in bone regeneration and repair.

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Workshop / Seminar Thu, 09 Jan 2020 09:53:25 -0500 2020-01-09T16:00:00-05:00 2020-01-09T17:00:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar BME Event
UROP Summer Research Fellowship Deadline Extended (January 10, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507918@events.umich.edu Event Begins: Friday, January 10, 2020 7:00am
Location: Undergraduate Science Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-01-10T07:00:00-05:00 2020-01-10T23:59:00-05:00 Undergraduate Science Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (January 11, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507919@events.umich.edu Event Begins: Saturday, January 11, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-01-11T07:00:00-05:00 2020-01-11T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (January 12, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507920@events.umich.edu Event Begins: Sunday, January 12, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-01-12T07:00:00-05:00 2020-01-12T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (January 13, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507921@events.umich.edu Event Begins: Monday, January 13, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-01-13T07:00:00-05:00 2020-01-13T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (January 14, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507922@events.umich.edu Event Begins: Tuesday, January 14, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-01-14T07:00:00-05:00 2020-01-14T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
Bioethics Discussion: Others (January 14, 2020 7:00pm) https://events.umich.edu/event/52724 52724-12974157@events.umich.edu Event Begins: Tuesday, January 14, 2020 7:00pm
Location: Lurie Biomedical Engineering
Organized By: The Bioethics Discussion Group

A discussion on us and them, but mostly them.

Readings to consider:
1. Neuroethics and the Problem of Other Minds: Implications of Neuroscience for the Moral Status of Brain-Damaged Patients and Nonhuman Animals
2. Undocumented Patients: Undocumented Immigrants and Access to Health Care
3. Bioethics and International Human Rights
4. Against culturally sensitive bioethics

For more information and/or to receive a copy of the readings contact Barry Belmont at belmont@umich.edu or visit http://belmont.bme.umich.edu/bioethics-discussion-group/discussions/038-others/.

I hear every one else is reading the blog: https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Thu, 09 Jan 2020 09:54:03 -0500 2020-01-14T19:00:00-05:00 2020-01-14T20:30:00-05:00 Lurie Biomedical Engineering The Bioethics Discussion Group Lecture / Discussion Others
UROP Summer Research Fellowship Deadline Extended (January 15, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507923@events.umich.edu Event Begins: Wednesday, January 15, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-01-15T07:00:00-05:00 2020-01-15T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
DCMB Weekly Seminar (January 15, 2020 4:00pm) https://events.umich.edu/event/70964 70964-17760238@events.umich.edu Event Begins: Wednesday, January 15, 2020 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract: Synchronization occurs all around us. It underlies how fireflies flash as one, how human heart cells beat in unison, and how superconductors conduct electricity with no resistance. Synchronization is present in the precision of the cell cycle, and we can explore how breakdown of precision leads to disease. The many unique and fundamental functions of different cell types are achieved over and over independently, through a form of synchronization involving choreography of many proteins and genes. I will share a general historic and descriptive introduction to synchrony, including the classic work of Alan Turing. I will present some new work done jointly with Cleve Moler (MathWorks) and Steve Smale (UC Berkeley), where biology has inspired us to build new mathematical techniques to explore synchrony and its breakdown.

BlueJeans Livestream: https://primetime.bluejeans.com/a2m/live-event/rbuvycdc

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Lecture / Discussion Mon, 06 Jan 2020 15:39:08 -0500 2020-01-15T16:00:00-05:00 2020-01-15T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
UROP Summer Research Fellowship Deadline Extended (January 16, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507924@events.umich.edu Event Begins: Thursday, January 16, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-01-16T07:00:00-05:00 2020-01-16T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
Being Human in STEM: An Experiment in Partnering with Students to Address Issues of Equity in STEM (January 16, 2020 12:00pm) https://events.umich.edu/event/69259 69259-17275351@events.umich.edu Event Begins: Thursday, January 16, 2020 12:00pm
Location: Rackham Graduate School (Horace H.)
Organized By: LSA Biophysics

When student protesters occupied the Amherst College library for four days in November of 2015, the campus community was transfixed by the painful testimonials shared by marginalized students about their experiences at Amherst as individuals identifying as Black, brown, female, queer, trans, disabled, international, among others. In response to letters from a Black neuroscience major and a non-binary biochemistry and biophysics major, every STEM department wrote a letter of support, pledging to work with students to address their concerns. The following semester, Chemistry professor Sheila Jaswal collaborated with students to develop a project-based course, titled “Being Human in STEM” (HSTEM), to actively engage STEM students and departments in learning about and enhancing inclusion in STEM settings. Now in its sixth iteration, students drive the academic inquiry, investigating both the local experience and the literature on diversity in STEM. They then use that research to design tools and interventions to share with and enhance their own STEM community.  In this seminar, Professor Jaswal will describe how HSTEM course projects and activities have continued the conversation started by students during the Uprising, connected STEM inclusion efforts across the Amherst campus, and produced resources such as the “Inclusive Curricular Practices” handbook, that have been used by STEM educators from high schools, colleges, universities, and the Howard Hughes Medical Institute Inclusive Excellence institutions. She will present evidence on the impact of the HSTEM course and practices on students, faculty and staff at Amherst, and provide examples of how a growing network of institutions, including Yale, Brown, Williams, and the University of Utah, are adapting the HSTEM model to their own STEM community needs. 

Please visit website for more information on speaker: http://www.beinghumaninstem.com/sheila-jaswal.html

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Workshop / Seminar Wed, 08 Jan 2020 12:58:03 -0500 2020-01-16T12:00:00-05:00 2020-01-16T14:00:00-05:00 Rackham Graduate School (Horace H.) LSA Biophysics Workshop / Seminar Rackham Graduate School (Horace H.)
BME 500: Brian Aguado, Ph.D. (January 16, 2020 4:00pm) https://events.umich.edu/event/70417 70417-17594466@events.umich.edu Event Begins: Thursday, January 16, 2020 4:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

he future Aguado Research Group will develop “precision biomaterials” that enable the evaluation of a patient’s unique biology to diagnose and treat a variety of health disorders as a function of sex, age, and/or ancestry. Precision medicine is a movement in clinical practice that seeks to develop therapies tailored for specific patients or subsets of patients. As mounting evidence suggests that the “one size fits all” approach to medicine is ineffective, my future lab seeks to exploit biomaterials as in vitro culture tools or implantable devices in vivo to understand how patient-specific variables may impact disease onset, progression, and treatment. In my talk, I will describe my past, present, and future work in precision biomaterials. During my graduate training with Prof. Lonnie Shea at Northwestern University, I developed implantable biomaterial scaffolds for the recruitment and early detection of metastatic cancer cells, which may serve as a platform to capture disseminating tumor cells for downstream precision medicine applications. My current postdoctoral research with Prof. Kristi Anseth at the University of Colorado Boulder is focused on engineering personalized in vitro disease models of aortic valve stenosis using serum from individual aortic valve stenosis patients to culture valve and cardiac fibroblasts and hydrogels as extracellular matrix mimics. I will also share my outlook for future work in exploring sex differences in cardiovascular disorders using precision biomaterials. In sum, precision biomaterials may serve as tools to improve our understanding of how patient-specific variables impact disease mechanisms and guide more effective diagnostics and treatments for individual patients or subsets of patients.

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Lecture / Discussion Fri, 10 Jan 2020 11:27:07 -0500 2020-01-16T16:00:00-05:00 2020-01-16T17:00:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Lecture / Discussion Brian Aguado
Taubman Tech Talk: DNA Methylation (January 16, 2020 5:00pm) https://events.umich.edu/event/71321 71321-17817081@events.umich.edu Event Begins: Thursday, January 16, 2020 5:00pm
Location:
Organized By: A. Alfred Taubman Medical Research Institute

pigenetic modifications are important drivers of development, health, and disease. DNA methylation is one type of epigenetic mark that can be measured in blood or other human samples. DNA methylation marks are associated with genetics and environmental exposures, which represents a useful tool for public health and medicine.

This presentation will give an overview of current technologies for DNA methylation measurements, describe methodological challenges associated with these methods, and provide evidence-based opportunities for future DNA methylation studies.

Kelly M. Bakulski, Ph.D. is an Assistant Professor in the Department of Epidemiology at the University of Michigan School of Public Health. Dr. Bakulski’s research goal is to understand the environmental and genetic etiologies of neurological disorders, including autism spectrum disorder and Alzheimer’s disease.

Dr. Bakulski incorporates population approaches and laboratory experiments to develop biomarker and cell type tools to better inform epigenetic inferences.

CME credit is available to physicians.

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Lecture / Discussion Mon, 13 Jan 2020 08:57:27 -0500 2020-01-16T17:00:00-05:00 2020-01-16T18:00:00-05:00 A. Alfred Taubman Medical Research Institute Lecture / Discussion Kelly Bakulski, PhD
UROP Summer Research Fellowship Deadline Extended (January 17, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507925@events.umich.edu Event Begins: Friday, January 17, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-01-17T07:00:00-05:00 2020-01-17T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
Electronics in the Brain – Literally (January 17, 2020 1:00pm) https://events.umich.edu/event/71584 71584-17842691@events.umich.edu Event Begins: Friday, January 17, 2020 1:00pm
Location: Gerald Ford Library
Organized By: Electrical and Computer Engineering

Abstract

Reading the human mind by electronic means used to be the domain of science fiction – and is still largely so. At the same time, technologies collectively labelled as brain-computer interfaces have moved forward, motivated by needs for assistive tools for neurologically impaired people and to advance our fundamental understanding of the brain. An applied example would be the use of electronic means to read out directly from the brain the intention to move an arm or a hand, and to decipher such signals to actuate an external robotic device. Another example is the
reading out brain signals produced when listening to or formulating speech. To access brain’s microcircuits at high space-time resolution requires implantation of electronic listening posts, call them nodes, at a number of nearby locations in a given functional area of the cortex. Which brings up the question of the day for neuroengineers: how many nodes might be required or are possible to implant, and how does one physically implement arrays of microscale electronic probes? What are the data rates involved in extracting brain signals and how to design a communication link to send the data onward for decoding by external computing platforms? What about reversing the direction of the process to use implanted probes to deliver signals directly into the brain (‘write-in’)? Through contemporary examples, this presentation will review recent accomplishments in the field from an electrical engineer’s viewpoint and discuss both the challenges and opportunities ahead to build next generations of brain-computer interfaces while explicitly exploiting many of the early 21st century advances in microelectronics, telecommunication, and high end computing.

Bio

Arto V. Nurmikko, a native of Finland, is a L. Herbert Ballou University Professor of Engineering and Physics at Brown. He received his degrees from University of California, Berkeley, with postdoctoral stays at MIT and Hebrew University. Professor Nurmikko conducts research in neuroengineering, brain sciences, nanophotonics and microelectronics, especially for the translation of device research to new technologies in biomedical, life science, and photonics applications. His current interests include development of implantable brain communication interfaces, microscale neural circuit sensors, compact semiconductor lasers, and high resolution acoustic microscopy. Professor Nurmikko is a Fellow of the American Physical Society, Fellow of the Institute of Electrical and Electronics Engineers, and Fellow of the Optical Society of America. He has been the recipient of a Guggenheim Fellowship, and elected to the American Academy of Arts and Sciences and to the Academy of Letters and Science of Finland. He was the co-recipient of the Israel Brain Prize in 2013.

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Lecture / Discussion Thu, 16 Jan 2020 11:10:47 -0500 2020-01-17T13:00:00-05:00 2020-01-17T14:30:00-05:00 Gerald Ford Library Electrical and Computer Engineering Lecture / Discussion Gerald Ford Library
UROP Summer Research Fellowship Deadline Extended (January 18, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507926@events.umich.edu Event Begins: Saturday, January 18, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-01-18T07:00:00-05:00 2020-01-18T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (January 19, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507927@events.umich.edu Event Begins: Sunday, January 19, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-01-19T07:00:00-05:00 2020-01-19T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (January 20, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507928@events.umich.edu Event Begins: Monday, January 20, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-01-20T07:00:00-05:00 2020-01-20T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (January 21, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507929@events.umich.edu Event Begins: Tuesday, January 21, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-01-21T07:00:00-05:00 2020-01-21T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (January 22, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507930@events.umich.edu Event Begins: Wednesday, January 22, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-01-22T07:00:00-05:00 2020-01-22T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
Welcome MUSES (January 22, 2020 11:30am) https://events.umich.edu/event/71502 71502-17836313@events.umich.edu Event Begins: Wednesday, January 22, 2020 11:30am
Location: Duderstadt Center
Organized By: MUSES

This semester we will have monthly lunches designed to build our community of women of color in STEM field. We would like to invite you to come and have lunch with us and celebrate the new semester. Relaxation coloring activities will also be available.

When: Wed, Jan 22nd, 11:30am-1pm
Where: Duderstadt 1120 Conference Room D

Please, RSVP here so enough food is provided
https://forms.gle/YHUSoeLUHAy5gvMY9

Mark on your calendar following events (all at the same location)
MUSES personal finance - Wed, Feb 26th, 11:30am-1pm
MUSES personal journal - Wed, Mar 25th, 11:30am-1pm
MUSES commemoration - Wed, Apr 15th, 11:30am-1pm

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Meeting Wed, 15 Jan 2020 13:37:10 -0500 2020-01-22T11:30:00-05:00 2020-01-22T13:00:00-05:00 Duderstadt Center MUSES Meeting Statue of a woman thinking
EER Seminar Series (January 22, 2020 3:30pm) https://events.umich.edu/event/70268 70268-17556192@events.umich.edu Event Begins: Wednesday, January 22, 2020 3:30pm
Location: Lurie Robert H. Engin. Ctr
Organized By: Engineering Education Research

Team-based pedagogies are pervasive in higher education, especially in engineering. Some instructors choose group work for logistical reasons, such as “we only have five testbeds.” Others seek to provide a particular student experience: students can teach and learn from each other, they can undertake more complicated projects, and they can develop collaboration skills that will benefit them later in their careers. Whatever the reason for using team-based pedagogies, instructors must be cognizant of team dysfunctions – some of which are invisible to the instructors or even to members of the team – that can affect certain students’ experiences in our classes.

In this talk, I will (1) present evidence that particular groups are more likely to have negative team experiences (and that teamwork is inherently gendered and raced), (2) suggest mechanisms for identifying and remedying some team dysfunctions, and (3) argue that instructors have a moral obligation to critically examine teamwork practices in an attempt to equitably serve our diverse student population.

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Lecture / Discussion Thu, 12 Dec 2019 10:48:31 -0500 2020-01-22T15:30:00-05:00 2020-01-22T16:30:00-05:00 Lurie Robert H. Engin. Ctr Engineering Education Research Lecture / Discussion Dr. Robin Fowler
UROP Summer Research Fellowship Deadline Extended (January 23, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507931@events.umich.edu Event Begins: Thursday, January 23, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-01-23T07:00:00-05:00 2020-01-23T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
BME 500: Dr. Hua Wang (January 23, 2020 4:00pm) https://events.umich.edu/event/70066 70066-17505688@events.umich.edu Event Begins: Thursday, January 23, 2020 4:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Talk Overview:

Cancer immunotherapy has achieved significant clinical success in the past few years, but there remains tremendous room for the development of new-generation therapies with more robust and persistent antitumor immune responses. My research interests are largely directed towards understanding how cancer cells and immune cells can be manipulated or engineered using chemistry, material, and chemical biology approaches, in order to develop effective therapies for cancers, injured tissues, and other diseases. In this talk, I will start with my phd journey in exploring cancer-selective metabolic labeling and targeting, and then share how metabolic cell labeling can be utilized for tracking and targeted modulation of immune cells in vivo. Lastly, I will talk about a biomaterial-based antigen-free cancer vaccine for the treatment of poorly-immunogenic solid tumors.

Bio:

I am currently a Wyss Technology Development Fellow at Harvard University, aiming to integrate my research background in chemistry, materials science, and chemical biology with cancer immunotherapy and immunoengineering here. More specifically, I am exploring approaches to modulate or engineer cancer and immune cells in vivo, in order to improve and innovate current immunotherapies for cancers and other immune-related diseases. Before moving to Harvard, I earned my Ph.D. degree in Materials Science and Engineering at the University of Illinois at Urbana-Champaign (08/2012-06/2016), and my Bachelor’s degree in Polymer Science and Engineering at the University of Science and Technology of China (08/2008-06/2012).

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Workshop / Seminar Thu, 09 Jan 2020 09:54:33 -0500 2020-01-23T16:00:00-05:00 2020-01-23T17:00:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar Dr. Hua Wang
UROP Summer Research Fellowship Deadline Extended (January 24, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507932@events.umich.edu Event Begins: Friday, January 24, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-01-24T07:00:00-05:00 2020-01-24T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (January 25, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507933@events.umich.edu Event Begins: Saturday, January 25, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-01-25T07:00:00-05:00 2020-01-25T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (January 26, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507934@events.umich.edu Event Begins: Sunday, January 26, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-01-26T07:00:00-05:00 2020-01-26T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (January 27, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507935@events.umich.edu Event Begins: Monday, January 27, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-01-27T07:00:00-05:00 2020-01-27T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (January 28, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507936@events.umich.edu Event Begins: Tuesday, January 28, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-01-28T07:00:00-05:00 2020-01-28T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
Bioethics Discussion: Michigan (January 28, 2020 7:00pm) https://events.umich.edu/event/52725 52725-12974158@events.umich.edu Event Begins: Tuesday, January 28, 2020 7:00pm
Location: Lurie Biomedical Engineering
Organized By: The Bioethics Discussion Group

A discussion on our state.

Readings to consider:
1. 2019 State of the State
2. Michigan Health Policy for the Incoming 2019 Gubernatorial Administration
3. ACA Exchange Competitiveness in Michigan
4. Flint Water Crisis: What Happened and Why?

For more information and/or to receive a copy of the readings contact Barry Belmont at belmont@umich.edu or visit http://belmont.bme.umich.edu/bioethics-discussion-group/discussions/039-michigan/.

For the ever-present state of things, consider the blog: https://belmont.bme.umich.edu/incidental-art/




...Flint still doesn't have clean drinking water.

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Lecture / Discussion Thu, 09 Jan 2020 09:55:44 -0500 2020-01-28T19:00:00-05:00 2020-01-28T20:30:00-05:00 Lurie Biomedical Engineering The Bioethics Discussion Group Lecture / Discussion Michigan
UROP Summer Research Fellowship Deadline Extended (January 29, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507937@events.umich.edu Event Begins: Wednesday, January 29, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-01-29T07:00:00-05:00 2020-01-29T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
DCMB Seminar Series (January 29, 2020 4:00pm) https://events.umich.edu/event/71998 71998-17911963@events.umich.edu Event Begins: Wednesday, January 29, 2020 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Talk Title: Experimental and computational strategies to aid compound identification and quantitation in metabolomics

Abstract: Over the past two decades, metabolomics as a technique has moved from the primary domain of analytical chemists to more widespread acceptance by biologists, clinicians and bioinformaticians alike. Metabolomics offers systems-level insights into the critical roles small molecules play in routine cellular processes and myriad disease states. However, certain unique analytical challenges remain prominent in metabolomics as compared to the other ‘omics sciences. These include the difficulty of identifying unknown features in untargeted metabolomics data, and challenges maintaining reliable quantitation within lengthy studies that may span multiple laboratories. Unlike genomics and transcriptomics data in which nearly every quantifiable feature is confidently identified as a matter of course, in typical untargeted metabolomics studies over 80% of features are frequently not mapped to a specific chemical compound. Further, although many metabolomics studies have begun to stretch over a timeframe of years, data quantitation and normalization strategies have not always kept up with the requirements for such large studies. Fortunately, both experimental and computational strategies are emerging to tackle these long-standing challenges. We will report on several techniques in development in our laboratory, ranging from chromatographic fractionation and high-sensitivity data acquisition, to computational strategies to aid in tandem mass spectrometric spectral interpretation. These developments serve to facilitate analysis for both experts and novice users, which should ultimately help improve the biological insight and impact gained from metabolomics data.

BlueJeans livestreaming link: https://primetime.bluejeans.com/a2m/live-event/rbuvycdc

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Lecture / Discussion Fri, 24 Jan 2020 11:07:13 -0500 2020-01-29T16:00:00-05:00 2020-01-29T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
UROP Summer Research Fellowship Deadline Extended (January 30, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507938@events.umich.edu Event Begins: Thursday, January 30, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-01-30T07:00:00-05:00 2020-01-30T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
BME 500: Meghan Driscoll, Ph.D. (January 30, 2020 4:00pm) https://events.umich.edu/event/70418 70418-17594468@events.umich.edu Event Begins: Thursday, January 30, 2020 4:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Signaling is governed not only by the expression levels of molecules, but by their localization via mechanisms as diverse as compartmentalization in organelles, phase separation, and directed transport by motor proteins. Cell morphology likely also modulates the localization of signaling molecules, and recent advances in high-resolution light-sheet microscopy, such as lattice light-sheet microscopy, now allow imaging at the spatiotemporal resolution needed to capture the many undulations and quick dynamics of the 3D cell surface. However, these microscopes generate large datasets with detailed 3D movies that are impossible to interpret without a dedicated computational pipeline. In this seminar, I will introduce u-shape3D, a computer graphics and machine-learning pipeline to probe molecular mechanisms underlying 3D cell morphogenesis. U-shape3D includes a generic morphological motif detector that automatically finds lamellipodia, filopodia, blebs and other motifs in order to test the intriguing possibility that morphogenesis itself affects intracellular signaling.

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Lecture / Discussion Thu, 23 Jan 2020 11:24:58 -0500 2020-01-30T16:00:00-05:00 2020-01-30T17:00:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Lecture / Discussion BME Logo
UROP Summer Research Fellowship Deadline Extended (January 31, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507939@events.umich.edu Event Begins: Friday, January 31, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-01-31T07:00:00-05:00 2020-01-31T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (February 1, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507940@events.umich.edu Event Begins: Saturday, February 1, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-02-01T07:00:00-05:00 2020-02-01T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (February 2, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507941@events.umich.edu Event Begins: Sunday, February 2, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-02-02T07:00:00-05:00 2020-02-02T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (February 3, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507942@events.umich.edu Event Begins: Monday, February 3, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-02-03T07:00:00-05:00 2020-02-03T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
BME Student Speaker: Xiaotian Tan (February 3, 2020 12:00pm) https://events.umich.edu/event/72234 72234-17963872@events.umich.edu Event Begins: Monday, February 3, 2020 12:00pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: Biomedical Engineering

Biosensors are devices or systems that can be used to detect, quantify, and analyze targets with biological activities and functions. As one of the largest subsets of biosensors, biomolecular sensors are specifically developed and programmed to detect, quantify and analyze biomolecules in liquid samples. Wide-ranging applications have made immunoassays increasingly popular for biomolecular detection and quantification. Among these, enzyme-linked immunosorbent assays (ELISA) are of particular interest due to high specificity and reproducibility. To some extent, ELISA has been regarded as a “gold standard” for quantifying analytes (especially protein analytes) in both clinical diagnostics and fundamental biological research. However, traditional (96-well plate-based) ELISA still suffers from several notable drawbacks, such as long assay time (4–6 hours), lengthy procedures, and large sample/reagent consumption (∼100 μL). These inherent disadvantages still significantly limit traditional ELISA's applicability to areas such as rapid clinical diagnosis of acute diseases (e.g., viral pneumonia, acute organ rejection), and biological research that requires accurate measurements with precious or low abundance samples (e.g., tail vein serum from a mouse). Thus, a bimolecular sensing technology that has high sensitivity, short assay time, and small sample/reagent consumption is still strongly desired. In this dissertation, we introduce the development of a multifunctional and automated optofluidic biosensing platform that can resolve the aforementioned problems. In contrast to conventional plate-based ELISA, our optofluidic ELISA platform utilizes mass-producible polystyrene microfluidic channels with a high surface-to-volume ratio as the immunoassay reactors, which greatly shortens the total assay time. We also developed a low-noise signal amplification protocol and an optical signal quantification system that was optimized for the optofluidic ELISA platform. Our optofluidic ELISA platform provides several attractive features such as small sample/reagent consumption (<8 μL), short total assay time (30-45 min), high sensitivity (~1 pg/mL for most markers), and a broad dynamic range (3-4 orders of magnitude). Using these features, we successfully quantified mouse FSH (follicle stimulating hormone) concentration with a single drop of tail vein serum. We also successfully monitored bladder cancer progression in orthotopic xenografted mice with only <50 μL of mouse urine. More excitingly, we achieved highly-sensitive exosome quantification and multiplexed immuno-profiling with <40 ng/mL of total input protein (per assay). These remarkable milestones could not be achieved with conventional plate-based ELISA but were enabled by our unique optofluidic ELISA.

As an emerging member of the bimolecular sensor family, our optofluidic ELISA platform provides a high-performance and cost-effective tool for a plethora of applications, including endocrinal, cancer animal model, cellular biology, and even forensic science research. In the future, this technology platform can also be renovated for clinical applications such as personalized cancer diagnosis/prognosis and rapid point-of-care diagnostics for infectious diseases.

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Lecture / Discussion Thu, 30 Jan 2020 09:19:52 -0500 2020-02-03T12:00:00-05:00 2020-02-03T13:00:00-05:00 Lurie Biomedical Engineering (formerly ATL) Biomedical Engineering Lecture / Discussion Xiaotian Tan
UROP Summer Research Fellowship Deadline Extended (February 4, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507943@events.umich.edu Event Begins: Tuesday, February 4, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-02-04T07:00:00-05:00 2020-02-04T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (February 5, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507944@events.umich.edu Event Begins: Wednesday, February 5, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-02-05T07:00:00-05:00 2020-02-05T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
Science as Art Contest Submission Deadline (February 5, 2020 11:55am) https://events.umich.edu/event/48786 48786-17963888@events.umich.edu Event Begins: Wednesday, February 5, 2020 11:55am
Location: Hatcher Graduate Library
Organized By: Arts at Michigan

Arts at Michigan, ArtsEngine and the Science Learning Center invite you to submit artwork to the 2020 Science as Art exhibition. University of Michigan undergraduate students are invited to submit artwork expressing a scientific principle(s), concept(s), idea(s), process(es), and/or structure(s). The artwork may be visual, literary, musical, video, or performance based. A juried panel using criteria based on both scientific and artistic considerations will choose winning submissions.

Deadline for submissions is Wednesday February 5th!

A number of submissions will be selected for prizes, some of which will be on display and/or performed during the Awards Ceremony and/or displayed in an online Contest Gallery. The entry selected for “Best Overall” will be awarded a cash prize, with smaller cash awards in other categories.

For full information, visit: tinyurl.com/scienceasart2020

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Exhibition Thu, 30 Jan 2020 11:47:29 -0500 2020-02-05T11:55:00-05:00 2020-02-05T23:59:00-05:00 Hatcher Graduate Library Arts at Michigan Exhibition Science as Art logo
UROP Summer Research Fellowship Deadline Extended (February 6, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507945@events.umich.edu Event Begins: Thursday, February 6, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-02-06T07:00:00-05:00 2020-02-06T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
BME 500: Jun Li, Ph.D. (February 6, 2020 4:00pm) https://events.umich.edu/event/70419 70419-17594471@events.umich.edu Event Begins: Thursday, February 6, 2020 4:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

In today’s research we often talk about knowledge-extraction from Big Data, and integration across different scales: molecules, cells, tissues/organs, organisms and their communities. The pursuit of multi-scale synthesis has a long history. For the microscopic world we have largely succeeded in connecting the chemical properties of molecules with the facts of atoms and their constituents and interactions. In epidemiology, many are currently applying linear mixed models to quantify the genetic contribution of disease risks in the general population. By and large, we live with the tacit belief that basic principles, once found, will be simple and elegant, and that we can build Systems Biology from the ground level. This leads to a pointillistic research culture, as when we try to explain the heredity of complex traits by summing up the individual actions of millions of DNA variants, or when we look for the neural basis of behavior by the connectivity and firing patterns of millions of neurons.
I will use this talk to share some thoughts on the emerging appreciation that, in biomedical data science, perhaps the best one can learn is not widely generalizable Mechanisms, but different laws for different scales of organization. There may not be a good chance, and perhaps no need, to "know" a system by brute force accumulation of larger and larger data at the bottom level. Acknowledging the irreducibility of highly-level phenomena in biology and medicine can help us appreciate the distinct methods, norms, and compromises in traditional disciplines, and steer the society's investment towards balanced collection of good data on all levels. By giving up the blind celebration of sample size, we give more attention to new technologies that can measure what was previously inaccessible, and to the next-generation of information science that embraces messy, context-specific models.

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Lecture / Discussion Fri, 31 Jan 2020 15:04:28 -0500 2020-02-06T16:00:00-05:00 2020-02-06T17:00:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Lecture / Discussion BME Logo
UROP Summer Research Fellowship Deadline Extended (February 7, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507946@events.umich.edu Event Begins: Friday, February 7, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-02-07T07:00:00-05:00 2020-02-07T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
Startup Career Fair (February 7, 2020 12:00pm) https://events.umich.edu/event/72206 72206-17957291@events.umich.edu Event Begins: Friday, February 7, 2020 12:00pm
Location: Duderstadt Center
Organized By: MPowered Entrepreneurship

Startup Career Fair provides students with the opportunity to pursue their passion and get paid for it. From Productiv in San Francisco to Choco from Berlin, world-renowned startups with mission-driven teams are waiting to hire you.

We invite you to join us on February 7 from 12-4pm at the Duderstadt Center on North Campus. Register by February 4th and you'll be entered into a lottery for an invitation to our exclusive networking breakfast with recruiters. Can’t wait to see you #Launch.

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Careers / Jobs Wed, 29 Jan 2020 13:06:39 -0500 2020-02-07T12:00:00-05:00 2020-02-07T16:00:00-05:00 Duderstadt Center MPowered Entrepreneurship Careers / Jobs #Launch
UROP Summer Research Fellowship Deadline Extended (February 8, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507947@events.umich.edu Event Begins: Saturday, February 8, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-02-08T07:00:00-05:00 2020-02-08T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
Paint and Pour- with people like you (February 8, 2020 3:00pm) https://events.umich.edu/event/72084 72084-17937812@events.umich.edu Event Begins: Saturday, February 8, 2020 3:00pm
Location: Chrysler Center
Organized By: MUSES

The Movement of Underrepresented Sisters in Engineering and Science (MUSES) will be getting together and learning how to do a beautiful painting with Alesha Jackson. This is a great time to relax and build a community among minority women on campus.

When: Sat, Feb 8th 3pm
Where: Chrysler, Room 265 (North Campus)

Please, RSVP here so enough supplies can be provided
https://forms.gle/BgLHdQ97HAk3MrkC9

Event is sponsored by RSG and the College of Engineering

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Meeting Mon, 27 Jan 2020 07:45:58 -0500 2020-02-08T15:00:00-05:00 2020-02-08T17:00:00-05:00 Chrysler Center MUSES Meeting Chrysler Center
UROP Summer Research Fellowship Deadline Extended (February 9, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507948@events.umich.edu Event Begins: Sunday, February 9, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-02-09T07:00:00-05:00 2020-02-09T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (February 10, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507949@events.umich.edu Event Begins: Monday, February 10, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-02-10T07:00:00-05:00 2020-02-10T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
STEM Identities and the UM Experience (February 10, 2020 5:30pm) https://events.umich.edu/event/72267 72267-17966041@events.umich.edu Event Begins: Monday, February 10, 2020 5:30pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: MUSES

How has your identity impacted your experience at U-M? Engage in welcoming group conversations to unpack how troubling individual experiences have common threads. Groups will brainstorm solutions we can enact and strategies we can use to move forward and address issues we’re facing on campus. Be on the lookout for future events like this! Dinner provided!
Please RSVP: https://bit.ly/2NvYMMx

Date: Mon, Feb. 10th
Time: 5:30-7:30pm
Location: Johnson Rooms, 3rd Floor, Lurie Engineering Center

Co-Sponsors: SHPE-GC, GSBES, MUSES, GEO, SFTP, MSE GSC, ME Dept, and CoE OSA.

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Meeting Thu, 30 Jan 2020 14:26:41 -0500 2020-02-10T17:30:00-05:00 2020-02-10T19:30:00-05:00 Lurie Biomedical Engineering (formerly ATL) MUSES Meeting Different people with different identities celebrating and doing different things
UROP Summer Research Fellowship Deadline Extended (February 11, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507950@events.umich.edu Event Begins: Tuesday, February 11, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-02-11T07:00:00-05:00 2020-02-11T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
Bioethics Discussion: Love (February 11, 2020 7:00pm) https://events.umich.edu/event/52726 52726-12974160@events.umich.edu Event Begins: Tuesday, February 11, 2020 7:00pm
Location: Lurie Biomedical Engineering
Organized By: The Bioethics Discussion Group

A discussion on the chemistry of our biology.

Readings to consider:
1. The Neurobiology of Love
2. The Medicalization of Love
3. Self-Transcendence, the True Self, and Self-Love
4. Love yourself: The relationship of the self with itself in popular self-help texts

For more information and/or to receive a copy of the readings contact Barry Belmont at belmont@umich.edu or visit http://belmont.bme.umich.edu/bioethics-discussion-group/discussions/040-love/.

You might love the blog: https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Thu, 09 Jan 2020 09:56:11 -0500 2020-02-11T19:00:00-05:00 2020-02-11T20:30:00-05:00 Lurie Biomedical Engineering The Bioethics Discussion Group Lecture / Discussion Love
UROP Summer Research Fellowship Deadline Extended (February 12, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507951@events.umich.edu Event Begins: Wednesday, February 12, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-02-12T07:00:00-05:00 2020-02-12T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
BME Ph.D Defense: Xiaotian Tan (February 12, 2020 11:00am) https://events.umich.edu/event/72235 72235-17963874@events.umich.edu Event Begins: Wednesday, February 12, 2020 11:00am
Location: Cooley Building
Organized By: Biomedical Engineering

Biosensors are devices or systems that can be used to detect, quantify, and analyze targets with biological activities and functions. As one of the largest subsets of biosensors, biomolecular sensors are specifically developed and programmed to detect, quantify and analyze biomolecules in liquid samples.

Wide-ranging applications have made immunoassays increasingly popular for biomolecular detection and quantification. Among these, enzyme-linked immunosorbent assays (ELISA) are of particular interest due to high specificity and reproducibility. To some extent, ELISA has been regarded as a “gold standard” for quantifying analytes (especially protein analytes) in both clinical diagnostics and fundamental biological research. However, traditional (96-well plate-based) ELISA still suffers from several notable drawbacks, such as long assay time (4–6 hours), lengthy procedures, and large sample/reagent consumption (∼100 μL). These inherent disadvantages still significantly limit traditional ELISA's applicability to areas such as rapid clinical diagnosis of acute diseases (e.g., viral pneumonia, acute organ rejection), and biological research that requires accurate measurements with precious or low abundance samples (e.g., tail vein serum from a mouse). Thus, a bimolecular sensing technology that has high sensitivity, short assay time, and small sample/reagent consumption is still strongly desired.

In this dissertation, we introduce the development of a multifunctional and automated optofluidic biosensing platform that can resolve the aforementioned problems. In contrast to conventional plate-based ELISA, our optofluidic ELISA platform utilizes mass-producible polystyrene microfluidic channels with a high surface-to-volume ratio as the immunoassay reactors, which greatly shortens the total assay time. We also developed a low-noise signal amplification protocol and an optical signal quantification system that was optimized for the optofluidic ELISA platform.

Our optofluidic ELISA platform provides several attractive features such as small sample/reagent consumption (<8 µL), short total assay time (30-45 min), high sensitivity (~1 pg/mL for most markers), and a broad dynamic range (3-4 orders of magnitude). Using these features, we successfully quantified mouse FSH (follicle stimulating hormone) concentration with a single drop of tail vein serum. We also successfully monitored bladder cancer progression in orthotopic xenografted mice with only <50 µL of mouse urine. More excitingly, we achieved highly-sensitive exosome quantification and multiplexed immuno-profiling with <40 ng/mL of total input protein (per assay). These remarkable milestones could not be achieved with conventional plate-based ELISA but were enabled by our unique optofluidic ELISA.

As an emerging member of the bimolecular sensor family, our optofluidic ELISA platform provides a high-performance and cost-effective tool for a plethora of applications, including endocrinal, cancer animal model, cellular biology, and even forensic science research. In the future, this technology platform can also be renovated for clinical applications such as personalized cancer diagnosis/prognosis and rapid point-of-care diagnostics for infectious diseases.

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Lecture / Discussion Thu, 30 Jan 2020 09:28:04 -0500 2020-02-12T11:00:00-05:00 2020-02-12T12:00:00-05:00 Cooley Building Biomedical Engineering Lecture / Discussion Xiaotian Tan
EER Seminar Series (February 12, 2020 3:30pm) https://events.umich.edu/event/72341 72341-17974693@events.umich.edu Event Begins: Wednesday, February 12, 2020 3:30pm
Location: Lurie Robert H. Engin. Ctr
Organized By: Engineering Education Research

Abstract:
Learning analytics dashboards (LADs) have emerged from a growing interest in presenting and visualizing students’ learning activities in digital learning environments, and they are growing in popularity for both residential and online courses. Dashboard displays are seen as powerful metacognitive tools, and delivering them to learners is intended to support awareness and decision-making, and trigger self-reflection. Despite their increasing availability, recent meta-reviews of the existing research on LADs have revealed that there are few empirical studies on the impact of dashboards on student motivation, behavior, and skills. In this talk I will present the student dashboard we have designed and tested here at the University at Michigan, called MyLA (My Learning Analytics). In a partnership between the School of Information, School of Education, and the Teaching and Learning group at ITS, we have created a Canvas-integrated dashboard that uses design principles derived from Self-Regulated Learning (SRL) theory combined with a focus on accessible and actionable information. Based data from 10 Winter 2019 courses where MyLA was available, I will describe our early findings about how UM students have used the dashboard, and the relationships between dashboard use with performance and measures of self-regulation.

Bio: Dr. Teasley is a Research Professor in the School of Information, the Director of the Learning Education & Design Lab (LED Lab), and Core Faculty member of the Michigan Institute for Data Science (MIDAS) at the University of Michigan. Her recent work has focused on assembling and utilizing institutionally-held student data to design and evaluate new ways to support student success in Higher Education. From 2016-2018 she was the president of the Society for Learning Analytics Research (SoLAR), and she is currently the chair of the International Alliance for the Advancement of Learning in the Digital Era (IAALDE).

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Lecture / Discussion Fri, 31 Jan 2020 15:19:52 -0500 2020-02-12T15:30:00-05:00 2020-02-12T16:30:00-05:00 Lurie Robert H. Engin. Ctr Engineering Education Research Lecture / Discussion Stephanie Teasley
Department of Computational Medicine & Bioinformatics (DCMB) Weekly Seminar (February 12, 2020 4:00pm) https://events.umich.edu/event/72535 72535-18015945@events.umich.edu Event Begins: Wednesday, February 12, 2020 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract:
Normal mechanical function of the heart requires that ATP be continuously synthesized at a hydrolysis potential of roughly -60 kJ mol-1. Yet in both the aging and diseased heart the relationships between cardiac work rate and concentrations of ATP, ADP, and inorganic phosphate are altered. Important outstanding questions are: To what extent do changes in metabolite concentrations that occur in aging and heart disease affect metabolic/molecular processes in the myocardium? How are systolic and diastolic functions affected by changes in metabolite concentrations? Does metabolic energy supply represent a limiting factor in determining physiological maximal cardiac power output and exercise capacity? Does the derangement of cardiac energetics that occurs with heart failure cause exercise intolerance?

To answer these questions, we have developed a multi-physics multi-scale model of cardiac energy metabolism and cardiac mechanics that simulates the dependence of myocardial ATP demand on muscle dynamics and the dependence of muscle dynamics on cardiac energetics. Model simulations predict that the maximal rate at which ATP can be synthesized at free energies necessary to drive physiological mechanical function determine maximal heart rate, cardiac output, and cardiac power output in exercise. Furthermore, we find that reductions in cytoplasmic adenine nucleotide, creatine, and phosphate pools that occur with aging impair the myocardial capacity to synthesize ATP at physiological free energy levels, and that the resulting changes to myocardial energetic status play a causal role in contributing to reductions in maximal cardiac power output with aging. Finally, model predictions reveal that reductions in cytoplasmic metabolite pools contribute to energetic dysfunction in heart failure, which in turn contributes to causing systolic dysfunction in heart failure.

BlueJeans Livestream Link: https://primetime.bluejeans.com/a2m/live-event/rbuvycdc

3:45 p.m. - Light Refreshments served in Forum Hall Atrium
4:00 p.m. - Lecture in Forum Hall

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Lecture / Discussion Wed, 05 Feb 2020 08:41:29 -0500 2020-02-12T16:00:00-05:00 2020-02-12T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
UROP Summer Research Fellowship Deadline Extended (February 13, 2020 7:00am) https://events.umich.edu/event/70080 70080-17507952@events.umich.edu Event Begins: Thursday, February 13, 2020 7:00am
Location: 1027 E. Huron Building
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-02-13T07:00:00-05:00 2020-02-13T23:59:00-05:00 1027 E. Huron Building UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
BME 500: Leyuan Ma, Ph.D. (February 13, 2020 4:00pm) https://events.umich.edu/event/70420 70420-17594472@events.umich.edu Event Begins: Thursday, February 13, 2020 4:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Chimeric antigen receptor (CAR) T-cell therapy has shown dramatic clinical responses in hematologic malignancies, with a high proportion of durable complete remissions elicited in leukemia and lymphomas. However, achieving the full promise of CAR T-cell therapy, especially in solid tumors, will require further advances in this form of cellular therapy. A key challenge is maintaining a sufficient pool of functional CAR T cells in vivo. We recently developed a strategy to target vaccines to lymph nodes, by linking peptide antigens to albumin-binding phospholipid-polymers. Constitutive trafficking of albumin from blood to lymph makes it ideal chaperone to concentrate these “amphiphile-vaccine” molecules in lymph nodes that would otherwise be rapidly dispersed in the bloodstream following parenteral injection. These lipid-polymer conjugates also exhibit the property that they insert in cell membranes on arrival in lymph nodes. Here, we generated amphiphile CAR T ligand (amph-ligand) vaccine by exploiting these dual lymph node targeting and membrane-decorating properties to repeatedly expand and rejuvenate CAR T cells through the chimeric receptor in native lymph node microenvironment. We evaluated this approach in the presence of a complete host immune system. Amph-ligand vaccine boosting triggered massive CAR T expansion, increased donor cell polyfunctionality, and enhanced anti-tumor efficacy in multiple immunocompetent tumor models. We demonstrate two approaches to generalize this strategy to any CAR, enabling this simple HLA-independent vaccination approach to enhance CAR T functionality to be applied to existing CAR T cell designs. Taken together, our amph-ligand vaccine provides a simple engineering solution to augment CAR T-cell therapy.

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Lecture / Discussion Fri, 07 Feb 2020 13:11:56 -0500 2020-02-13T16:00:00-05:00 2020-02-13T17:00:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Lecture / Discussion BME Logo
UROP Summer Research Fellowship Deadline Extended (February 14, 2020 6:00am) https://events.umich.edu/event/70080 70080-17507953@events.umich.edu Event Begins: Friday, February 14, 2020 6:00am
Location:
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-02-14T06:00:00-05:00 2020-02-14T17:00:00-05:00 UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
UROP Summer Research Fellowship Deadline Extended (February 17, 2020 11:00am) https://events.umich.edu/event/70080 70080-18120894@events.umich.edu Event Begins: Monday, February 17, 2020 11:00am
Location:
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-02-17T11:00:00-05:00 2020-02-17T23:00:00-05:00 UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
MCIRCC Re-Imagining Critical Care Seminar Series (February 17, 2020 3:00pm) https://events.umich.edu/event/71948 71948-17903306@events.umich.edu Event Begins: Monday, February 17, 2020 3:00pm
Location: North Campus Research Complex Building 10
Organized By: Michigan Center for Integrative Research in Critical Care (MCIRCC)

“Innovation Fundamentals & Opportunities in Critical Care Biomarker Discovery”

Frederick Korley MD, PhD is an Associate Professor of Emergency Medicine.

Dr. Korley's research activities involve translation of novel diagnostics to inform clinically rational, timely, and cost-effective diagnosis of cardiac and brain injury in the emergency department. The goal of his traumatic brain injury work is to improve the acute care diagnosis, risk-stratification and treatment of TBI by identifying distinct molecular subtypes of TBI that will allow for targeted treatment and improved outcomes.

DETAILS & REGISTRATION:
http://bit.ly/FrederickKorley

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Workshop / Seminar Thu, 23 Jan 2020 12:02:33 -0500 2020-02-17T15:00:00-05:00 2020-02-17T16:00:00-05:00 North Campus Research Complex Building 10 Michigan Center for Integrative Research in Critical Care (MCIRCC) Workshop / Seminar MCIRCC Re-Imagining Critical Care Seminar Series with Dr. Frederick K. Korley Flyer
UROP Summer Research Fellowship Deadline Extended (February 18, 2020 7:00am) https://events.umich.edu/event/70080 70080-18120895@events.umich.edu Event Begins: Tuesday, February 18, 2020 7:00am
Location:
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-02-18T07:00:00-05:00 2020-02-18T23:00:00-05:00 UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
Donuts in the Dude with ISD (February 18, 2020 11:00am) https://events.umich.edu/event/72802 72802-18079305@events.umich.edu Event Begins: Tuesday, February 18, 2020 11:00am
Location: Duderstadt Center
Organized By: Integrative Systems + Design

Stop by, grab a Washtenaw Dairy Donut, and learn more about Integrative Systems + Design!

Interested in vehicle electrification, advances in fuel technologies, cleaner energy, or a host of other challenges? ISD is the place for innovative graduate programs that prepare you to become a leader in your field.

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Other Wed, 12 Feb 2020 13:01:32 -0500 2020-02-18T11:00:00-05:00 2020-02-18T12:30:00-05:00 Duderstadt Center Integrative Systems + Design Other Donuts with ISD
UROP Summer Research Fellowship Deadline Extended (February 19, 2020 1:00am) https://events.umich.edu/event/70080 70080-18120896@events.umich.edu Event Begins: Wednesday, February 19, 2020 1:00am
Location:
Organized By: UROP - Undergraduate Research Opportunity Program

Extended Deadline Wednesday, February 19th, 2020 at 5pm
Apply today at: http://myumi.ch/lxmbp

UROP sponsors several summer research opportunities designed for University of Michigan undergraduate students seeking an intense research experience in traditional laboratory settings and in the community. These fellowships provide students with the chance to undertake and complete individual research projects; learn firsthand about the life of an academic researcher; think about academic and post graduate careers; and develop strong mentor relationships.

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Careers / Jobs Mon, 17 Feb 2020 11:17:33 -0500 2020-02-19T01:00:00-05:00 2020-02-19T17:00:00-05:00 UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Summer Application Graphic
BME Ph.D. Defense: Lauren L. Zimmerman (February 20, 2020 10:00am) https://events.umich.edu/event/72566 72566-18018159@events.umich.edu Event Begins: Thursday, February 20, 2020 10:00am
Location: Lurie Robert H. Engin. Ctr
Organized By: Biomedical Engineering

Department of Biomedical Engineering Final Oral Examination

Lauren L. Zimmerman

Investigating Neuromodulation as a Treatment for Female Sexual Dysfunction

Female sexual dysfunction (FSD) affects millions of women worldwide. FSD has a significant impact on quality of life and interpersonal relationships. The prevalence of at least one form of sexual dysfunction is 40-45% of adult women with 12% of women experiencing sexually related personal distress, yet there is no clear treatment option for a wide range of FSD deficits with high efficacy and low side effects.

Neuromodulation techniques using electrical stimulation of peripheral nerves have the potential to treat some forms of FSD. In clinical trials of sacral neuromodulation (SNM) and percutaneous tibial nerve stimulation (PTNS) for bladder dysfunction, women have reported that their sexual dysfunction symptoms improved as well. Even though this effect has been observed clinically, very little research has been done to examine the mechanisms or the optimal method of treatment specifically for women with FSD. This thesis aims to bridge that gap by investigating neuromodulation as a treatment for FSD through both preclinical and clinical studies.

The first aim of this thesis is to investigate a possible mechanism of the improvement to sexual functioning in response to tibial nerve stimulation by evaluating vaginal blood flow responses in rats. In 16 ketamine-anesthetized female rats, the tibial nerve was stimulated for 30 minutes while vaginal blood perfusion was recorded with laser Doppler flowmetry. A novel signal analysis and quantification metric was developed for this analysis. I found that tibial nerve stimulation could drive prolonged increases in vaginal blood perfusion, typically after 20-30 minutes of stimulation. This result suggests that clinical neuromodulation may be improving FSD symptoms by increasing genital blood flow.

One question yet to be investigated by neuromodulation studies is whether tibial nerve stimulation could be an on-demand treatment for FSD, such as Viagra is for men, or is more appropriate as a long-term treatment with improvements over time, such as PTNS for bladder dysfunction. In this thesis I address this question by evaluating the sexual motivation and receptivity of female rats both immediately after a single stimulation session as well as after long-term, repeated stimulation sessions. I found that tibial nerve stimulation led to modest increases in sexual motivation in the short term, and larger increases in sexual receptivity in the long-term.

Lastly, this thesis evaluates a pilot clinical study of transcutaneous stimulation of the dorsal genital and posterior tibial nerves in nine women with FSD. The women received stimulation once a week for 12 weeks and their sexual functioning was measured using the Female Sexual Function Index (FSFI) at baseline, after 6 weeks of stimulation, after 12 weeks of stimulation, and at 18 weeks (6 weeks after the last stimulation session). The average total FSFI score across all subjects significantly increased from baseline to each of the time points in the study. Significant FSFI increases were seen in the sub-domains of lubrication, arousal, and orgasm, each of which is related to genital arousal.

This thesis provides evidence that peripheral neuromodulation can be an effective treatment for FSD. The stimulation is likely driving increases in genital blood flow, with greater effects observed when stimulation is repeatedly applied over time. This treatment has the potential to help millions of women worldwide.

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Lecture / Discussion Wed, 05 Feb 2020 15:00:05 -0500 2020-02-20T10:00:00-05:00 2020-02-20T11:00:00-05:00 Lurie Robert H. Engin. Ctr Biomedical Engineering Lecture / Discussion BME Logo
Microfluidics Seminar: Dr. Xufeng Xue (February 20, 2020 12:00pm) https://events.umich.edu/event/73026 73026-18129602@events.umich.edu Event Begins: Thursday, February 20, 2020 12:00pm
Location: Pierpont Commons
Organized By: Biomedical Engineering

Neurulation is a key embryonic developmental process that gives rise to neural tube (NT), the precursor structure that eventually develops into the central nervous system (CNS). Understanding the molecular mechanisms and morphogenetic events underlying human neurulation is important for the prevention and treatment of neural tube defects (NTDs) and neurodevelopmental disorders. However, animal models are limited in revealing many fundamental aspects of neurulation that are unique to human CNS development. Furthermore, the technical difficulty and ethical constraint in accessing neurulation-stage human embryos have significantly limited experimental investigations of early human CNS development.
I leveraged the developmental potential and self-organizing property of human pluripotent stem cells (hPSCs) in conjunction with 2D and 3D bioengineering tools to achieve the development of spatially patterned multicellular tissues that mimic certain aspects of human neurulation, including neuroectoderm patterning and dorsal-ventral (DV) patterning of NT.
In the first section, I report a micropatterned hPSC-based neuroectoderm model, wherein pre-patterned geometrical confinement induces emergent patterning of neuroepithelial (NE) and neural plate border (NPB) cells, mimicking neuroectoderm patterning during early neurulation. My data support the hypothesis that in this hPS cell-based neuroectoderm patterning model, two tissue-scale morphogenetic signals, cell shape and cytoskeletal contractile force, instruct NE / NPB patterning via BMP-SMAD signaling. This work provides evidence of tissue mechanics-guided neuroectoderm patterning and establishes a tractable model to study signaling crosstalk involving both biophysical and biochemical determinants in neuroectoderm patterning.
In the second section, I report a human NT development model, in which NT-like tissues, termed NE cysts, are generated in a bioengineered neurogenic environment through self-organization of hPSCs. DV patterning of NE cysts is achieved using retinoic acid and/or Sonic Hedgehog, featuring sequential emergence of the ventral floor plate, p3 and pMN domains in discrete, adjacent regions and dorsal territory that is progressively restricted to the opposite dorsal pole.

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Lecture / Discussion Tue, 18 Feb 2020 08:58:46 -0500 2020-02-20T12:00:00-05:00 2020-02-20T13:00:00-05:00 Pierpont Commons Biomedical Engineering Lecture / Discussion BME Logo
BME 500: Ruixuan Gao (February 20, 2020 4:00pm) https://events.umich.edu/event/70421 70421-17594473@events.umich.edu Event Begins: Thursday, February 20, 2020 4:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Investigation of the molecular basis of a complex biological system, such as the brain, can lead to fundamental understanding of its composition and function, and to a new strategy to repair it. Such investigation, however, requires a tool that can capture biological structures and their molecular constituents across multiple orders of magnitude—from nanometers to centimeters—in length. Electron microscopy offers nanoscopic resolution but lacks molecular information to differentiate endogenous biomolecules as well as imaging speed to cover millimeter-scale specimens. Light microscopy provides molecular contrast but is limited by optical diffraction and the tradeoff between imaging speed and photobleaching.

In this talk, I will first introduce an optical imaging pipeline named expansion lattice light-sheet microscopy (ExLLSM) and its application to multiplexed, volumetric imaging of molecular constituents in cells and intact tissues. Using ExLLSM, our study has revealed molecular-specific structures of organelles, synapses, myelin sheaths, and neurites in rodent and insect brains at ∼60 by 60 by 90 nm effective resolution across dimensions that span millimeters. Next, I will present two recently developed methods that further extend the resolution and throughput of ExLLSM: (1) a non-radical hydrogel chemistry that forms a homogenous polymer network and physically separates biomolecules or fluorescent labels up to 40-fold linearly, and (2) a multi-modal optical microscopy that enables rapid, high-resolution imaging of both expanded and live tissues. Lastly, I will discuss the significance of these imaging methods in the context of microanatomy and functional omics.

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Lecture / Discussion Thu, 13 Feb 2020 10:34:18 -0500 2020-02-20T16:00:00-05:00 2020-02-20T17:00:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Lecture / Discussion BME Logo
LHS Collaboratory (February 25, 2020 12:00pm) https://events.umich.edu/event/72208 72208-18035597@events.umich.edu Event Begins: Tuesday, February 25, 2020 12:00pm
Location: 1027 E. Huron Building
Organized By: Department of Learning Health Sciences

"Value Proposition of Learning Health Systems"
Erik Gordon, PhD
Clinical Assistant Professor, Ross School of Business, University of Michigan
Tuesday, February 25, 2020 – 12 pm–1:30 pm
Great Lakes Room, Palmer Commons (Lunch is included)

Professor Gordon's areas of interest are entrepreneurship and technology commercialization, venture capital, private equity, mergers and acquisitions, corporate governance, the biomedical industry (pharmaceuticals, devices, healthcare big data, and biotechnology), IoT, FinTech, and digital and mobile marketing. He also served on the faculty of University of Michigan Law School. He has served on the faculty and as Associate Dean and Director of the Graduate Division of Business & Management (Carey Business School) at Johns Hopkins University, where he taught in the business and medical schools and at the University of Florida, where he also served as director of the Center for Technology & Science Commercialization Studies and as Director of MBA Programs. He has served as an adviser or co-founder to numerous companies. He is frequently quoted in The New York Times, BusinessWeek, The Wall Street Journal, Bloomberg, Reuters and other outlets, is a regular contributor to Marketplace Morning Report (in NPR's Morning Edition), Bloomberg Radio, and appears on PBS's Nightly Business Report. His degrees are in economics and law.
Please register in advance, dlhs-umi.ch/lhs-collaboratory.
Email: LHScollaboratory-info@umich.edu

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Lecture / Discussion Fri, 07 Feb 2020 15:07:52 -0500 2020-02-25T12:00:00-05:00 2020-02-25T13:30:00-05:00 1027 E. Huron Building Department of Learning Health Sciences Lecture / Discussion LHS Collaboratory
Bioethics Discussion: Overpopulation (February 25, 2020 7:00pm) https://events.umich.edu/event/52727 52727-12974161@events.umich.edu Event Begins: Tuesday, February 25, 2020 7:00pm
Location: Lurie Biomedical Engineering
Organized By: The Bioethics Discussion Group

A discussion on one to(o) many.

Readings to consider:
1. Having Children: Reproductive Ethics in the Face of Overpopulation
2. The Ethics of Controlling Population Growth in the Developing World
3. Overpopulation and the Threat of Ecological Disaster: The Need for Global Bioethics
4. Threats and burdens: Challenging scarcity-driven narratives of “overpopulation”

For more information and/or to receive a copy of the readings contact Barry Belmont at belmont@umich.edu or visit http://belmont.bme.umich.edu/bioethics-discussion-group/discussions/041-overpopulation/.

If it's not too crowded, consider the blog: https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Thu, 09 Jan 2020 09:56:30 -0500 2020-02-25T19:00:00-05:00 2020-02-25T20:30:00-05:00 Lurie Biomedical Engineering The Bioethics Discussion Group Lecture / Discussion Overpopulation
BME 500: Kelly Stevens (February 27, 2020 4:00pm) https://events.umich.edu/event/70067 70067-17505693@events.umich.edu Event Begins: Thursday, February 27, 2020 4:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

The notion of building artificial human organs has moved from a far-fetched concept to the forefront of regenerative medicine research. While progress is being made, most tissues created to date are simply not large enough to support clinically meaningful functions, and their structural features remain an magnitude coarser in resolution than native tissues. Few organs better represent this challenge than the liver – the largest visceral organ in the human body, in which hepatocytes are aligned in single cell-width structures entangled with vascular and biliary networks. To address this challenge, we are working to develop a portfolio of tools that integrate 3D printing, synthetic biology, and the innate capacity of cells to self-assemble. We are applying these tools to decode the signals that drive tissue assembly during development, and using this information to build scaled artificial tissues that replicate the features of native tissues.

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Workshop / Seminar Thu, 20 Feb 2020 11:04:16 -0500 2020-02-27T16:00:00-05:00 2020-02-27T17:00:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar BME Event
Book Club - Part 1: More than enough: claiming space for who you are (no matter what they say), by Elaine Welteroth (February 27, 2020 6:00pm) https://events.umich.edu/event/72085 72085-17937813@events.umich.edu Event Begins: Thursday, February 27, 2020 6:00pm
Location: Duderstadt Center
Organized By: MUSES

The Movement of Underrepresented Sisters in Engineering and Science (MUSES) has a new book club this semester. The book chosen is "More More than enough: claiming space for who you are (no matter what they say), by Elaine Welteroth.

If you would like to join us with this book club, please RSVP with the link below:
https://forms.gle/6MBQY3WEyVwVL4VW7

Books will be given to people interested to come to our discussions.

When: Thu, Feb 27th, 6pm-7pm
Where: North Campus, room: TBD

for questions or more information, contact: umichmuses@gmail.com

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Meeting Mon, 27 Jan 2020 07:56:48 -0500 2020-02-27T18:00:00-05:00 2020-02-27T19:00:00-05:00 Duderstadt Center MUSES Meeting Duderstadt Center
Sarah D. Olson: Sperm Navigation in Complex Environments (February 28, 2020 3:00pm) https://events.umich.edu/event/72343 72343-17974695@events.umich.edu Event Begins: Friday, February 28, 2020 3:00pm
Location: East Hall
Organized By: Michigan Institute for Computational Discovery and Engineering

Abstract: Microorganisms can swim in a variety of environments, interacting with chemicals and other proteins in the fluid. In this talk, we will highlight recent computational methods and results for swimming efficiency and hydrodynamic interactions of swimmers in different fluid environments. Sperm are modeled via a centerline representation where forces are solved for using elastic rod theory. The method of regularized Stokeslets is used to solve the fluid-structure interaction where emergent swimming speeds can be compared to asymptotic analysis. In the case of fluids with extra proteins or cells that may act as friction, swimming speeds may be enhanced and attraction may not occur.

Bio: Sarah Olson is an Associate Professor in the Department of Mathematical Sciences at Worcester Polytechnic Institute. Olson received her undergraduate degrees in Mathematics and Biology from Providence College, a master’s from the University of Rhode Island in Mathematics, and a PhD in Biomathematics from North Carolina State University. She has worked in the general areas of fluid dynamics, scientific computing, and mathematical biology.

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Workshop / Seminar Fri, 31 Jan 2020 16:26:07 -0500 2020-02-28T15:00:00-05:00 2020-02-28T16:00:00-05:00 East Hall Michigan Institute for Computational Discovery and Engineering Workshop / Seminar S.D. Olson
2020 MASSEY TBI GRAND CHALLENGE KICKOFF (March 5, 2020 8:30am) https://events.umich.edu/event/69927 69927-17489276@events.umich.edu Event Begins: Thursday, March 5, 2020 8:30am
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Integrative Research in Critical Care (MCIRCC)

The Massey TBI Grand Challenge supports high-impact proposals by funding milestone-driven research over a 12-month timeframe.

This event is made possible thanks to a generous gift from the Joyce and Don Massey Family Foundation. Up to $650,000 is available in 2020 to fund the development of diagnostic, device, therapeutic, or health IT solutions that address the initial ‘golden hours’ of care after severe traumatic brain injury (generally the first 48 hours). Additionally, this year ALL current/past awardees and new awardees will be eligible for the Schwabauer Accelerator Award of $40,000. This will be a separate application.

Note: To be considered for funding, you must attend the Grand Challenge event.

Keynote Speaker:
Odette Harris, MD, MPH, Stanford University School of Medicine

DETAILS & REGISTRATION:
http://bit.ly/2020-TBI-Grand-Challenge

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Other Thu, 23 Jan 2020 12:04:54 -0500 2020-03-05T08:30:00-05:00 2020-03-05T16:00:00-05:00 North Campus Research Complex Building 18 Michigan Center for Integrative Research in Critical Care (MCIRCC) Other 2020 Massey TBI Grand Challenge
BME 500: Ruobo Zhou (March 5, 2020 4:00pm) https://events.umich.edu/event/73399 73399-18214945@events.umich.edu Event Begins: Thursday, March 5, 2020 4:00pm
Location: Industrial and Operations Engineering Building
Organized By: Biomedical Engineering

Biomolecular interactions are at the root of all biological processes and define the molecular mechanisms of how these processes are accomplished in both physiological and pathological conditions. Recent advances in single molecule detection and super-resolution fluorescence microcopy have uncovered previously unknown properties of biomolecular interactions, including multivalency, transiency, and heterogeneity, and revealed the organizational principles governing the compartmentalization of functional biomolecular interactions in cells and how such compartmentalization and organizations become dysregulated in diseases. In this talk, I will first discuss my postdoctoral work, where I used mass-spectrometry-based analysis and super-resolution imaging to dissect the protein-protein interactions at the plasma membrane of neurons, and discovered that a newly identified membrane-associated periodic skeleton (MPS) structure can function as a signaling platform that coordinates the interactions of signaling proteins at the plasma membrane of neurons. In response to extracellular stimuli, G-protein coupled receptors, cell-adhesion molecules, receptor tyrosine kinases can be recruited to the MPS to form signaling complexes at the plasma membrane, and such recruitment is required for downstream intracellular signaling. This work not only reveals an important, previously unknown function of the newly discovered MPS structure, but also provides novel mechanistic insights into signal transduction in neurons. I will then discuss my graduate work, where I developed a hybrid single molecule technique combining single molecule FRET and optical tweezers, and applied this technique to probe the sub-molecular dynamics of protein-DNA interactions in various biological systems involved in DNA replication, repair and recombination.

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Lecture / Discussion Fri, 28 Feb 2020 11:07:38 -0500 2020-03-05T16:00:00-05:00 2020-03-05T17:00:00-05:00 Industrial and Operations Engineering Building Biomedical Engineering Lecture / Discussion BME Logo
Forum on "Climate Change and Health: Readiness and Resilience" (March 10, 2020 12:00pm) https://events.umich.edu/event/72763 72763-18070598@events.umich.edu Event Begins: Tuesday, March 10, 2020 12:00pm
Location: Towsley Center for Cont. Med Ed
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

*Please register by going to http://mleead.umich.edu/Event_Climate_Change_and_Health_2020.php*

Our climate is our planet’s life support system. Climate change influences human health and disease in numerous ways, including impacts from increased extreme weather events, wildfire, decreased air quality, and illnesses transmitted by food, water, and disease carriers such as mosquitoes and ticks. As described in the Lancet Countdown report, some existing health threats will intensify and new health threats will emerge. Not everyone is equally at risk, and children are especially at risk. Preventive and adaptive actions are needed.

The keynote speaker is an emergency medicine physician who co-authored the U.S. portion of the Lancet Countdown report and Health and Care Delivery in the New England Journal of Medicine. A panel of experts will present solutions from a variety of other universities who are reducing their carbon footprint in response to the urgent public health need.

Welcome: Joseph C. Kolars, MD, Senior Associate Dean for Education and Global Initiatives, UM Medical School

Keynote: "Climate Action: Children’s Health Drives Need for Urgent Action" Renee N. Salas, MD, MPH, MS, Clinical Instructor of Emergency Medicine, Harvard Medical School and emergency medicine physician, Massachusetts General Hospital

Schedule
11:00-11:45 am | Registration outside of Dow Auditorium, Towsley Center for Continuing Medical Education, Michigan Medicine
11:00-11:45 am | Lunch in Towsley Center Dining Room for registered guests
12:00-1:30 pm | Program in Dow Auditorium, Towsley Center (also will be live streamed)
1:30-2:00 pm | Reception in Towsley Center Dining Room

*Please register by going to http://mleead.umich.edu/Event_Climate_Change_and_Health_2020.php*

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Conference / Symposium Fri, 21 Feb 2020 13:52:24 -0500 2020-03-10T12:00:00-04:00 2020-03-10T13:30:00-04:00 Towsley Center for Cont. Med Ed Michigan Lifestage Environmental Exposures and Disease Center Conference / Symposium Climate Change and Health: Readiness and Resilience
Bioethics Discussion: Public Health (March 10, 2020 7:00pm) https://events.umich.edu/event/52728 52728-12974162@events.umich.edu Event Begins: Tuesday, March 10, 2020 7:00pm
Location: Lurie Biomedical Engineering
Organized By: The Bioethics Discussion Group

A discussion on the health of our society.

Readings to consider:
1. The right to public health
2. Ethics and Public Health: Forging a Strong Relationship
3. Old Myths, New Myths: Challenging Myths in Public Health
4. A Bridge Back to the Future: Public Health Ethics, Bioethics, and Environmental Ethics

For more information and/or to receive a copy of the readings contact Barry Belmont at belmont@umich.edu or visit http://belmont.bme.umich.edu/bioethics-discussion-group/discussions/042-public-health/.

A public good for the good of the public – the blog: https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Thu, 09 Jan 2020 09:57:57 -0500 2020-03-10T19:00:00-04:00 2020-03-10T20:30:00-04:00 Lurie Biomedical Engineering The Bioethics Discussion Group Lecture / Discussion Public health
EER Seminar Series (March 11, 2020 3:30pm) https://events.umich.edu/event/73497 73497-18252264@events.umich.edu Event Begins: Wednesday, March 11, 2020 3:30pm
Location: Lurie Robert H. Engin. Ctr
Organized By: Engineering Education Research

Engineering design is complex, where each phase is dependent on the others and iteration occurs with and across these phases. Further, a successful design outcome hinges on foundational work done during the "front-end” of design processes, which includes problem definition, deep needs and stakeholder assessments using design ethnography, requirements development, and idea generation. Research has shown that experts develop both conscious and subconscious design strategies that impact success, and that novices often lack strategies and the ability to successfully implement them. This seminar will discuss investigations of strategies in front-end design, ways these strategies can be translated to design and education tools, and the role of front-end design in broadening recognition of skills that engineering includes.

BIOGRAPHICAL SKETCH: Dr. Shanna Daly is an Assistant Professor in Mechanical Engineering in the College of Engineering. She has a B.E. in Chemical Engineering from the University of Dayton and a Ph.D. degree in Engineering Education from Purdue University. Her research characterizes front-end design practices across the student to practitioner continuum, uses these findings to develop tools to support design best practices, and studies the impact of front-end design tools on design success. She focuses on divergent and convergent thinking processes, including concept generation and development and problem space exploration, how to foster creativity in engineering work, and processes to understand social and cultural elements of the contexts in which engineering work occurs and integrate them into decision making. Her studies often involve both professional and educational contexts and collaborations across disciplines with scholars in engineering, education, industrial design, and psychology.

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Lecture / Discussion Tue, 03 Mar 2020 13:00:21 -0500 2020-03-11T15:30:00-04:00 2020-03-11T16:30:00-04:00 Lurie Robert H. Engin. Ctr Engineering Education Research Lecture / Discussion Lurie Robert H. Engin. Ctr
DCMB Weekly Seminar (March 11, 2020 4:00pm) https://events.umich.edu/event/73002 73002-18123077@events.umich.edu Event Begins: Wednesday, March 11, 2020 4:00pm
Location:
Organized By: DCMB Seminar Series

Abstract:

In this talk, some major challenges are reviewed of using Artificial Intelligence (AI) to address the needs of medicine and healthcare. These challenges include technical issues such as data-related and/or algorithmic challenges that the use of AI for medicine would present. The speaker then presents some potential solutions in form of novel algorithmic approaches that may at least partially address some of these challenges.

BlueJeans livestream: https://primetime.bluejeans.com/a2m/live-event/rbuvycdc

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Lecture / Discussion Wed, 11 Mar 2020 08:49:28 -0400 2020-03-11T16:00:00-04:00 2020-03-11T17:00:00-04:00 DCMB Seminar Series Lecture / Discussion
BME 500: Rebecca Wachs (March 12, 2020 4:00pm) https://events.umich.edu/event/70068 70068-17505695@events.umich.edu Event Begins: Thursday, March 12, 2020 4:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

The majority of the population will experience low back pain in their lifetime. Degeneration of the intervertebral disc is highly correlated with low back pain, however, not all disc degeneration is painful. One of the most common forms of low back pain is disc-associated low back pain in which pain originates from intervertebral disc. In disc-associated low back pain, nerve fibers penetrate the previously aneural disc, where they are then thought to be stimulated by the harsh catabolic environment. Repetitive stimulation of these nerve fibers can cause sensitization and chronic pain. The overarching goal of our work is to engineer biomaterials that target these two key areas of disc-associated low back pain: nerve growth and stimulation. Current clinical treatments for chronic low back pain have limited efficacy or are highly invasive. The majority of research to date focuses on regenerating a young healthy disc. We believe our approach to target nerve growth and stimulation independent of disc regeneration has the potential shift the paradigm in the treatment of low back pain.

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Workshop / Seminar Tue, 10 Mar 2020 11:43:59 -0400 2020-03-12T16:00:00-04:00 2020-03-12T17:00:00-04:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar BME Event
Project Management Certification (March 15, 2020 12:00pm) https://events.umich.edu/event/73563 73563-18261071@events.umich.edu Event Begins: Sunday, March 15, 2020 12:00pm
Location: Ross School of Business
Organized By: Tauber Institute for Global Operations

Once again, the Tauber Institute, in conjunction with the International Project Management Association (IPMA), is sponsoring a Project Management certification class and exam for graduate business and engineering students and staff.

In order to participate, you will need to reflect upon a project management experience (for example a work project, an engineering design experience/senior capstone, Ross' MAP project, Tauber team project, etc). If you cannot make it to the classes (due to project travel, MAP, or other another class), the sessions will be recorded. Homework (mastery verification) will be required after each session.

The cost to an individual to take the exam is normally $595, however, Tauber is offering the exam at a substantial discount to non-Tauber students: $500 and to Tauber students: $150. Certification is valid for 5 years. Three certification classes will be taught by Professor Eric Svaan on the following dates:

Sunday, March 15 (noon - 4:30 pm, Ross R-0420)
Sunday, March 29 (noon - 4:30 pm, Ross R-0420)
Sunday, April 5 (noon - 4:30 pm, Ross R-0420)

The certification exam, administered by IPMA-USA is scheduled for April 26, 2020 (11:00 am) at the Ross School of Business, R-0320. Successfully passing the exam will yield IPMA's Level D certification (Certified Project Management Associate).

Over the last two years, all students who have taken the exam have passed!

Project Management is a powerful skillset to have in your toolbox as you look for full-time employment!

REGISTRATION: Please register through iMpact by clicking here:
http://myumi.ch/dO5Nl

NOTE: The $500 (for non-Tauber students) or $150 fee (for Tauber students) is non-refundable.

HOSTED BY: Tauber Institute for Global Operations. For questions about this event, please contact tauberinstitute@umich.edu or visit tauber.umich.edu.

What is IPMA Level D® (Certified Project Management Associate)? The IPMA Level D is an internationally recognized entry-level qualification in the area of project management. This designation, which demonstrates the individual's ability to understand the basics of project management, is similar to the exam-oriented, knowledge-based certifications of other major Project Management associations. For many, Level D® is the first step towards a professional project or program manager role. It is the first step in a sequence (C, B, and A) to be earned by demonstration of success in larger PM responsibility sets.

For more information,
Visit tauber.umich.edu or call 734-647-1333
Connect via email to Diana Crossley dianak@umich.edu

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Class / Instruction Thu, 05 Mar 2020 10:07:18 -0500 2020-03-15T12:00:00-04:00 2020-03-15T16:30:00-04:00 Ross School of Business Tauber Institute for Global Operations Class / Instruction Photo of certificate
Wolverine Wellness Workshop (March 16, 2020 6:00pm) https://events.umich.edu/event/73584 73584-18263275@events.umich.edu Event Begins: Monday, March 16, 2020 6:00pm
Location: Herbert H. Dow Building
Organized By: Graduate Society of Black Engineers and Scientists

Join wellness coach Chidimma Ozor as she shares insights on wellness strategies to help navigate some of the challenges & stresses of (grad) school. Topics will include stress reduction/ rejuvenation & holistic wellbeing. Food provided. No registration needed.

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Well-being Wed, 04 Mar 2020 20:24:43 -0500 2020-03-16T18:00:00-04:00 2020-03-16T19:00:00-04:00 Herbert H. Dow Building Graduate Society of Black Engineers and Scientists Well-being You Know Me
CANCELED: "Human Nature" panel discussion (March 18, 2020 7:30pm) https://events.umich.edu/event/72924 72924-18096982@events.umich.edu Event Begins: Wednesday, March 18, 2020 7:30pm
Location: Off Campus Location
Organized By: Precision Health

THE PANEL DISCUSSION HAS BEEN CANCELED.

For information about the film, please see Michigan Theater's website:
https://www.michtheater.org/show/human-nature/

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Film Screening Thu, 12 Mar 2020 09:49:25 -0400 2020-03-18T19:30:00-04:00 2020-03-18T22:00:00-04:00 Off Campus Location Precision Health Film Screening Human Nature
Ph.D. Defense: Ahmad Asif A Jiman (March 24, 2020 10:00am) https://events.umich.edu/event/73841 73841-18426650@events.umich.edu Event Begins: Tuesday, March 24, 2020 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be hosted via Zoom. You can log in with this link:

https://umich.zoom.us/j/329580834
Meeting ID: 329-580-834

Diabetic patients suffer from a long-term condition that results in high blood glucose levels (hyperglycemia). Many medications for diabetes lose their glycemic control effectiveness over time and patient compliance to these medications is a major challenge. Glycemic control is a vital continuous process and is innately regulated by the endocrine and autonomic nervous systems. There is an opportunity for developing an implantable and automated treatment for diabetic patients by accurately detecting and altering neural activity in autonomic nerves. The renal and vagus nerves contribute in glycemic control and are potential targets for this proposed treatment. This dissertation investigated stimulation of renal nerves for glycemic control, assembled an implantation procedure for neural interface arrays designed for autonomic nerves, and demonstrated high-fidelity physiological signals in the vagus nerve of rats.

Stimulation of renal nerves at kilohertz frequency (33 kHz) showed a notable average increase in urine glucose excretion (+24.5%). In contrast, low frequency (5 Hz) stimulation of renal nerves showed a decrease in glucose excretion (−40.4%). However, these responses may be associated with urine flow rate.

Kilohertz frequency stimulation (50 kHz) of renal nerves in diabetic rats showed a significant average decrease (-168.4%) in blood glucose concentration rate, and an increase (+18.9%) in the overall average area under the curve for urine glucose concentration, with respect to values before stimulation.

An innovative procedure was assembled for the chronic implantation of novel intraneural MIcroneedle Nerve Arrays (MINAs) in rat vagus nerves. Two array attachment approaches (fibrin sealant and rose-bengal bonding) were investigated to secure non-wired MINAs in rat vagus nerves. The fibrin sealant approach was unsuccessful in securing the MINA-nerve interface for 4- and 8-week implant durations. The rose-bengal coated MINAs were in close proximity to axons (≤ 50 μm) in 75% of 1-week and 14% of 6-week implants with no significant harm to the implanted nerves or the overall health of the rats.

Using Carbon Fiber Microelectrode Arrays (CFMAs), physiological neural activity was recorded on 51% of inserted functional carbon fibers in rat vagus nerves, and 1-2 neural clusters were sorted on each carbon fiber with activity. The mean peak-to-peak amplitudes of the sorted clusters were 15.1-91.7 µV with SNR of 2.0-7.0. Propagation of vagal signals were detected in the afferent direction at conduction velocities of 0.7-1.0 m/sec, and efferent signals at 0.7-8.8 m/sec, which are within the conduction velocity range of myelinated and unmyelinated vagus fibers. Furthermore, changes in vagal nerve activity were monitored in breathing and blood glucose modulated conditions.

Overall, this dissertation investigated modulation of neural activity for glycemic control, assembled a new chronic implantation procedure for nerve interface arrays, and monitored physiological signaling in an autonomic nerve. Future work is needed to fully understand the physiological neural signaling, and evaluate the long-term tissue reactivity and recording integrity of implanted electrodes in autonomic nerves. This work supports the potential development of an alternative implantable treatment modality for diabetic patients by modulating and monitoring neural activity in autonomic nerves.

Date: Tuesday, March 24, 2020
Time: 10:00 AM
Location: North Campus Research Complex (NCRC), B10-G64
Chair: Dr. Tim M. Bruns

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Lecture / Discussion Mon, 23 Mar 2020 14:08:39 -0400 2020-03-24T10:00:00-04:00 2020-03-24T11:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion U-M BME Event
LHS Collaboratory Webinar "Mobilizing Computable Biomedical Knowledge at Michigan Medicine" (March 24, 2020 12:00pm) https://events.umich.edu/event/72652 72652-18035599@events.umich.edu Event Begins: Tuesday, March 24, 2020 12:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Presentation 1:
"Electronic Health Record (EHR)-Integration for Learning Health Systems"

Michael Lanham, MD
Associate Chief Medical Information Officer
Clinical Assistant Professor of Learning Health Sciences
Assistant Professor of Obstetrics & Gynecology; Fertility and Reproductive Health
University of Michigan

Presentation 2:
“Machine Learning Infrastructure in a Learning Health System”

Karandeep Singh, MD, MMSc
Assistant Professor of Learning Health Sciences
Assistant Professor of Medicine
University of Michigan


Please register in advance, *dlhs-umi.ch/lhs-collaboratory. *
Email: *LHScollaboratory-info@umich.edu*

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Lecture / Discussion Wed, 18 Mar 2020 10:04:19 -0400 2020-03-24T12:00:00-04:00 2020-03-24T13:30:00-04:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion LHS Collaboratory
Bioethics Discussion: Solitude (March 24, 2020 7:00pm) https://events.umich.edu/event/52729 52729-12974163@events.umich.edu Event Begins: Tuesday, March 24, 2020 7:00pm
Location: Off Campus Location
Organized By: The Bioethics Discussion Group

NOTICE: This event will be held via Blue Jeans. The link is below.

https://bluejeans.com/7569798571

A discussion on who we are when we are alone.

Readings to consider:
1. The Solitude of Self
2. An overview of systematic reviews on the public health consequences of social isolation and loneliness
3. Individual Good and Common Good: A Communitarian Approach to Bioethics
4. Solitude: An Exploration of Benefits of Being Alone

For more information and/or to receive a copy of the readings contact Barry Belmont at belmont@umich.edu or visit http://belmont.bme.umich.edu/bioethics-discussion-group/discussions/043-solitude/.

Take some time alone with the blog: https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Mon, 23 Mar 2020 14:12:37 -0400 2020-03-24T19:00:00-04:00 2020-03-24T20:30:00-04:00 Off Campus Location The Bioethics Discussion Group Lecture / Discussion Solitude
Zhen Xu, PhD: Histotripsy Webinar (March 25, 2020 10:00am) https://events.umich.edu/event/73931 73931-18426654@events.umich.edu Event Begins: Wednesday, March 25, 2020 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This will be held online. Click the link below to register.

https://fusfoundation.zoom.us/webinar/register/WN_Hj_R2DMOT8SlOAp0WRLV3A

Oftentimes when we think of focused ultrasound, we imagine using it to heat and kill tissue. Unlike thermal ablation, histotripsy uses focused ultrasound to mechanically disrupt the target tissue without heating. Histotripsy turns the tissue into liquid-appearing acellular debris – which is absorbed by the body over one to two months – resulting in effective tissue removal.

Histotripsy has been shown to stimulate a powerful immune response in cancer treatment studies. In the treatment of neurological diseases, transcranial histotripsy can produce well-confined focal treatment in a wide range of locations and volumes in the brain, offering the potential to increase the treatment envelope while decreasing treatment time.

Please register to join us at 10:00 AM Eastern on Wednesday, March 25, when Zhen Xu, PhD, will discuss the basic mechanism, instrumentation, bioeffects, and applications of histotripsy. She will also cover the latest preclinical and clinical trial results of developing histotripsy for the treatment of cancer and neurological diseases.

About the Speaker

Zhen Xu, PhD, is a tenured Associate Professor in the Department of Biomedical Engineering at the University of Michigan and a primary inventor and pioneer in histotripsy.

She has received many notable awards, including:
IEEE Ultrasonics, Ferroelectrics, and Frequency Control Society Outstanding Paper Award (2006)
American Heart Association Outstanding Research in Pediatric Cardiology (2010)
National Institutes of Health (NIH) New Investigator Award at the First National Institute of Biomedical Imaging and Bioengineering (NIBIB) Edward C. Nagy New Investigator Symposium (2011)
The Federic Lizzi Early Career Award from The International Society of Therapeutic Ultrasound (ISTU) (2015)
Fellow of the American Institute of Medical and Biological Engineering (2019)
Dr. Xu is currently an associate editor for three notable journals: IEEE Transactions on Ultrasound, Ferroelectrics, and Frequency Control (UFFC); Frontiers in Bioengineering; and BME Frontiers. She is an elected board member of ISTU, a charter member of the US NIH study section, and a principal investigator of grants funded by the Focused Ultrasound Foundation, NIH, American Cancer Association, Office of Naval Research, The Hartwell Foundation, and The Coulter Foundation.

She received her PhD from the University of Michigan in 2005.

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Livestream / Virtual Mon, 23 Mar 2020 14:42:17 -0400 2020-03-25T10:00:00-04:00 2020-03-25T11:00:00-04:00 Off Campus Location Biomedical Engineering Livestream / Virtual BME Logo
Ph.D. Defense: Brittany Rodriguez (March 26, 2020 10:00am) https://events.umich.edu/event/73840 73840-18339520@events.umich.edu Event Begins: Thursday, March 26, 2020 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: Will be held via BlueJeans.

BlueJeans Link: https://umich.bluejeans.com/478989984

Volumetric muscle loss (VML) is the traumatic or surgical loss of skeletal muscle comprising 20-30% or more of the total muscle volume. By definition, VML exceeds the muscle’s capacity for self-repair and results in persistent functional deficits. Significantly, no treatment options exist that can fully restore native structure and function. To address the limitations of current treatments, our laboratory has developed tissue-engineered skeletal muscle units (SMUs) as a novel treatment for VML repair. SMUs have shown promising regenerative potential in a rat VML model; however, limitations of rodent models necessitated transitioning our technology to a large animal (sheep) model.



Despite substantial heterogeneity of muscle progenitor cell populations obtained from craniofacial, trunk, and limb muscle, engineered skeletal muscle tissues are almost exclusively fabricated from cells derived from hindlimb muscle, making the effects of cell source on engineered muscle tissue unknown. Thus, we conducted a comparison of SMUs fabricated from muscle cells isolated from both craniofacial and hindlimb muscle sources and evaluated the effects of these cell sources on SMU structure and function. Specifically, we showed that the semimembranosus muscle was the most clinically relevant muscle source for the fabrication of SMUs.

We also sought to develop a method to scale our SMUs to clinically relevant sizes. We developed a modular fabrication method that combines multiple smaller SMUs into a larger implantable graft. Consequently, we successfully fabricated of one of the largest engineered skeletal muscle tissues to date while avoiding the formation of a necrotic core. To treat peripheral nerve injuries that often accompany VML, we also developed engineered neural conduits (ENCs) to bridge gaps between healthy native nerve and the injury site. We used scaled-up SMUs and ENCs to treat a 30% VML in the ovine peroneus tertius muscle. After a 3-month recovery, SMU-treated groups restored muscle mass and force production to a level that was statistically indistinguishable from the uninjured contralateral muscle.

Lastly, we evaluated the efficacy of SMUs in repairing craniofacial VML. Despite reported differences in the regenerative capacity of craniofacial muscle compared to limb muscle, prior to my thesis there were no models of craniofacial VML in either large or small animal models. Thus, we introduced the first model of craniofacial VML and evaluated the ability of SMUs to treat a 30% VML in the zygomaticus major muscle. Despite using the same injury and repair model in both implantation studies, results showed differences in pathophysiology between craniofacial and hindlimb VML. The fibrotic response was increased in the facial muscle model, and there was tissue tethering and intramuscular fat deposition that was not observed in the hindlimb study. The craniofacial model was also confounded by concomitant denervation and ischemia injuries which was too severe for our SMUs to repair. This study highlighted the importance of balancing the use of a clinically realistic model while also maintaining control over variables related to the severity of the injury.

Overall, this work significantly contributed to the field of skeletal muscle tissue engineering by evaluating the effects of muscle source on the structure and function of SMUs, created a modular fabrication method for tissue scale-up, and introduced a new large animal model, and a craniofacial model of VML. The success of this technology demonstrates its potential for treating clinical VML in the future.

Chair: Dr. Lisa Larkin

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Lecture / Discussion Tue, 24 Mar 2020 14:49:10 -0400 2020-03-26T10:00:00-04:00 2020-03-26T11:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion U-M BME Event
Ph.D. Defense: Tyler Gerhardson (March 26, 2020 10:00am) https://events.umich.edu/event/73025 73025-18129601@events.umich.edu Event Begins: Thursday, March 26, 2020 10:00am
Location: Lurie Robert H. Engin. Ctr
Organized By: Biomedical Engineering

NOTICE: Will be held via BlueJeans.

Link: https://umich.bluejeans.com/924142541

Brain pathologies including stroke and cancer are a major cause of death and disability. Intracerebral hemorrhage (ICH) accounts for roughly 12% of all strokes in the US with approximately 200,000 new cases per year. ICH is characterized by the rupture of vessels resulting in bleeding and clotting inside the brain. The presence of the clot causes immediate damage to surrounding brain tissue via mass effect with delayed toxic effects developing in the days following the hemorrhage. This leads ICH patients to high mortality with a 40% chance of death within 30 days of diagnosis and motivates the need to quickly evacuate the clot from the brain. Craniotomy surgery and other minimally invasive methods using thrombolytic drugs are common procedures to remove the clot but are limited by factors such as morbidity and high susceptibility to rebleeding, which ultimately result in poor clinical outcomes.

Histotripsy is a non-thermal ultrasound ablation technique that uses short duration, high amplitude rarefactional pulses (>26 MPa) delivered via an extracorporeal transducer to generate targeted cavitation using the intrinsic gas nuclei existing in the target tissue. The rapid and energetic bubble expansion and collapse of cavitation create high stress and strain in tissue at the focus that fractionate it into an acellular homogenate. This dissertation presents the role of histotripsy as a novel ultrasound technology with potential to address the need for an effective transcranial therapy for ICH and other brain pathologies.

The first part of this work investigates the effects of ultrasound frequency and focal spacing on transcranial clot liquefaction using histotripsy. Histotripsy pulses were delivered using two 256-element hemispherical transducers of different frequency (250 and 500 kHz) with 30-cm aperture diameters. Liquefied clot was drained via catheter and syringe in the range of 6-59 mL in 0.9-42.4 min. The fastest rate was 16.6 mL/min. The best parameter combination was λ spacing at 500 kHz, which produced large liquefaction through 3 skullcaps (~30 mL) with fast rates (~2 mL/min). The temperature-rise through the 3 skullcaps remained below 4°C.

The second part addresses initial safety concerns for histotripsy ICH treatment through investigation in a porcine ICH model. 1.75-mL clots were formed in the frontal lobe of the brain. The centers of the clots were liquefied with histotripsy 48 h after formation, and the content was either evacuated or left within the brain. A control group was left untreated. Histotripsy was able to liquefy the core of clots without direct damage to the perihematomal brain tissue. An average volume of 0.9 ± 0.5 mL (~50%) was drained after histotripsy treatment. All groups showed mild ischemia and gliosis in the perihematomal region; however, there were no deaths or signs of neurological dysfunction in any groups.

The third part presents the development of a novel catheter hydrophone method for transcranial phase aberration correction and drainage of the clot liquefied with histotripsy. A prototype hydrophone was fabricated to fit within a ventriculostomy catheter. Improvements in focal pressure of up to 60% were achieved at the geometric focus and 27%-62% across a range of electronic steering locations. The sagittal and axial -6-dB beam widths decreased from 4.6 to 2.2 mm in the sagittal direction and 8 to 4.4 mm in the axial direction, compared to 1.5 and 3 mm in the absence of aberration. The cores of clots liquefied with histotripsy were readily drained via the catheter.

The fourth part focuses on the development of a preclinical system for translation to human cadaver ICH models. A 360-element, 700 kHz hemispherical array with a 30 cm aperture was designed and integrated with an optical tracker surgical navigation system. Calibrated simulations of the transducer suggest a therapeutic range between 48 – 105 mL through the human skull with the ability to apply therapy pulses at pulse-repetition-frequencies up to 200 Hz. The navigation system allows real-time targeting and placement of the catheter hydrophone via a pre-operative CT or MRI.

The fifth and final part of this work extends transcranial histotripsy therapy beyond ICH to the treatment of glioblastoma. This section presents results from an initial investigation into cancer immunomodulation using histotripsy in a mouse glioblastoma model. The results suggest histotripsy has some immunomodulatory capacity as evidenced by a 2-fold reduction in myeloid derived suppressor cells and large increases in interferon-γ concentrations (3500 pg/mL) within the brain tumors of mice treated with histotripsy.

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Lecture / Discussion Mon, 16 Mar 2020 13:26:52 -0400 2020-03-26T10:00:00-04:00 2020-03-26T11:00:00-04:00 Lurie Robert H. Engin. Ctr Biomedical Engineering Lecture / Discussion BME Logo
BME 500: Zach Danziger (March 26, 2020 4:00pm) https://events.umich.edu/event/70071 70071-17507736@events.umich.edu Event Begins: Thursday, March 26, 2020 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: Online hosting procedure TBD.

Therapeutic and Reparative Neurotechnology

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Workshop / Seminar Mon, 23 Mar 2020 14:23:16 -0400 2020-03-26T16:00:00-04:00 2020-03-26T17:00:00-04:00 Off Campus Location Biomedical Engineering Workshop / Seminar BME Event
E-Hour Speaker Series: Kathleen Sienko (March 27, 2020 12:30pm) https://events.umich.edu/event/72249 72249-17963889@events.umich.edu Event Begins: Friday, March 27, 2020 12:30pm
Location: Walgreen Drama Center
Organized By: Center for Entrepreneurship

The weekly Entrepreneurship Hour speaker series is back every Friday during the academic year, free and open to the public to attend.

Kathleen Sienko is an Arthur F. Thurnau Professor, Miller Faculty Scholar, and Associate Professor of Mechanical and Biomedical Engineering at the University of Michigan. She earned her Ph.D. in 2007 in Medical Engineering and Bioastronautics from the Harvard-MIT Division of Health Science and Technology, and holds an S.M. in Aeronautics & Astronautics from MIT and a B.S. in Materials Engineering from the University of Kentucky.

She is the co-director of the Center for Socially Engaged Design and directs both the Sensory Augmentation and Rehabilitation Laboratory (SARL) and the Laboratory for Innovation in Global Health Technology (LIGHT). LIGHT focuses on the co-creative design of frugal innovations to address healthcare challenges in resource-limited settings.

Professor Sienko has led efforts at the University of Michigan to incorporate the constraints of global health technologies within engineering design at the undergraduate and graduate levels and has led design ethnography field sites in India, Ghana, Uganda, Ethiopia and Nicaragua as the Director of the Global Health Design Initiative. She is the recipient of a CAREER Award from the National Science Foundation, a Teaching Innovation Prize from the UM Provost, and a UM Undergraduate Teaching Award.

In addition to Professor Sienko’s expertise topics, she consults on Design Process and Professional Development.

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Presentation Thu, 30 Jan 2020 11:53:29 -0500 2020-03-27T12:30:00-04:00 2020-03-27T13:30:00-04:00 Walgreen Drama Center Center for Entrepreneurship Presentation Sienko
Project Management Certification (March 29, 2020 12:00pm) https://events.umich.edu/event/73563 73563-18261072@events.umich.edu Event Begins: Sunday, March 29, 2020 12:00pm
Location: Ross School of Business
Organized By: Tauber Institute for Global Operations

Once again, the Tauber Institute, in conjunction with the International Project Management Association (IPMA), is sponsoring a Project Management certification class and exam for graduate business and engineering students and staff.

In order to participate, you will need to reflect upon a project management experience (for example a work project, an engineering design experience/senior capstone, Ross' MAP project, Tauber team project, etc). If you cannot make it to the classes (due to project travel, MAP, or other another class), the sessions will be recorded. Homework (mastery verification) will be required after each session.

The cost to an individual to take the exam is normally $595, however, Tauber is offering the exam at a substantial discount to non-Tauber students: $500 and to Tauber students: $150. Certification is valid for 5 years. Three certification classes will be taught by Professor Eric Svaan on the following dates:

Sunday, March 15 (noon - 4:30 pm, Ross R-0420)
Sunday, March 29 (noon - 4:30 pm, Ross R-0420)
Sunday, April 5 (noon - 4:30 pm, Ross R-0420)

The certification exam, administered by IPMA-USA is scheduled for April 26, 2020 (11:00 am) at the Ross School of Business, R-0320. Successfully passing the exam will yield IPMA's Level D certification (Certified Project Management Associate).

Over the last two years, all students who have taken the exam have passed!

Project Management is a powerful skillset to have in your toolbox as you look for full-time employment!

REGISTRATION: Please register through iMpact by clicking here:
http://myumi.ch/dO5Nl

NOTE: The $500 (for non-Tauber students) or $150 fee (for Tauber students) is non-refundable.

HOSTED BY: Tauber Institute for Global Operations. For questions about this event, please contact tauberinstitute@umich.edu or visit tauber.umich.edu.

What is IPMA Level D® (Certified Project Management Associate)? The IPMA Level D is an internationally recognized entry-level qualification in the area of project management. This designation, which demonstrates the individual's ability to understand the basics of project management, is similar to the exam-oriented, knowledge-based certifications of other major Project Management associations. For many, Level D® is the first step towards a professional project or program manager role. It is the first step in a sequence (C, B, and A) to be earned by demonstration of success in larger PM responsibility sets.

For more information,
Visit tauber.umich.edu or call 734-647-1333
Connect via email to Diana Crossley dianak@umich.edu

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Class / Instruction Thu, 05 Mar 2020 10:07:18 -0500 2020-03-29T12:00:00-04:00 2020-03-29T16:30:00-04:00 Ross School of Business Tauber Institute for Global Operations Class / Instruction Photo of certificate
BME 500: Alberto Figueroa (April 2, 2020 4:00pm) https://events.umich.edu/event/70072 70072-17507738@events.umich.edu Event Begins: Thursday, April 2, 2020 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be hosted via Blue Jeans. The link will be posted below.

Blue Jeans Link: https://umich.bluejeans.com/763221545

Dr. Figueroa received his PhD in Mechanical Engineering at Stanford University, where he developed computational methods fluid structure interaction simulation of hemodynamics.

His first academic appointment was a King’s College London in the UK, where he was Senior Lecturer in the Division of Biomedical Engineering and Imaging Sciences.

Dr. Figueroa is currently the Edward B. Diethrich M.D. Professor in Biomedical Engineering and Vascular Surgery at the University of Michigan. His laboratory is focused on three main areas: 1) developing tools for advanced modeling of blood flow. His group develops the modeling software CRIMSON (www.crimson.software); 2) studying the link between abnormal biomechanical stimuli and cardiovascular diseases such as hypertension and thrombosis; 3) simulation-based surgical planning to aid with the optimal planning of cardiovascular surgeries.

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Workshop / Seminar Wed, 01 Apr 2020 13:18:41 -0400 2020-04-02T16:00:00-04:00 2020-04-02T17:00:00-04:00 Off Campus Location Biomedical Engineering Workshop / Seminar BME Logo
Project Management Certification (April 5, 2020 12:00pm) https://events.umich.edu/event/73563 73563-18261073@events.umich.edu Event Begins: Sunday, April 5, 2020 12:00pm
Location: Ross School of Business
Organized By: Tauber Institute for Global Operations

Once again, the Tauber Institute, in conjunction with the International Project Management Association (IPMA), is sponsoring a Project Management certification class and exam for graduate business and engineering students and staff.

In order to participate, you will need to reflect upon a project management experience (for example a work project, an engineering design experience/senior capstone, Ross' MAP project, Tauber team project, etc). If you cannot make it to the classes (due to project travel, MAP, or other another class), the sessions will be recorded. Homework (mastery verification) will be required after each session.

The cost to an individual to take the exam is normally $595, however, Tauber is offering the exam at a substantial discount to non-Tauber students: $500 and to Tauber students: $150. Certification is valid for 5 years. Three certification classes will be taught by Professor Eric Svaan on the following dates:

Sunday, March 15 (noon - 4:30 pm, Ross R-0420)
Sunday, March 29 (noon - 4:30 pm, Ross R-0420)
Sunday, April 5 (noon - 4:30 pm, Ross R-0420)

The certification exam, administered by IPMA-USA is scheduled for April 26, 2020 (11:00 am) at the Ross School of Business, R-0320. Successfully passing the exam will yield IPMA's Level D certification (Certified Project Management Associate).

Over the last two years, all students who have taken the exam have passed!

Project Management is a powerful skillset to have in your toolbox as you look for full-time employment!

REGISTRATION: Please register through iMpact by clicking here:
http://myumi.ch/dO5Nl

NOTE: The $500 (for non-Tauber students) or $150 fee (for Tauber students) is non-refundable.

HOSTED BY: Tauber Institute for Global Operations. For questions about this event, please contact tauberinstitute@umich.edu or visit tauber.umich.edu.

What is IPMA Level D® (Certified Project Management Associate)? The IPMA Level D is an internationally recognized entry-level qualification in the area of project management. This designation, which demonstrates the individual's ability to understand the basics of project management, is similar to the exam-oriented, knowledge-based certifications of other major Project Management associations. For many, Level D® is the first step towards a professional project or program manager role. It is the first step in a sequence (C, B, and A) to be earned by demonstration of success in larger PM responsibility sets.

For more information,
Visit tauber.umich.edu or call 734-647-1333
Connect via email to Diana Crossley dianak@umich.edu

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Class / Instruction Thu, 05 Mar 2020 10:07:18 -0500 2020-04-05T12:00:00-04:00 2020-04-05T16:30:00-04:00 Ross School of Business Tauber Institute for Global Operations Class / Instruction Photo of certificate
Bioethics Discussion: Responsibility (April 7, 2020 7:00pm) https://events.umich.edu/event/52730 52730-12974164@events.umich.edu Event Begins: Tuesday, April 7, 2020 7:00pm
Location: Off Campus Location
Organized By: The Bioethics Discussion Group

A discussion on what we owe to ourselves and others.

NOTICE: Online hosting procedure https://bluejeans.com/7569798571.

Readings to consider:
1. Social Responsibilities of Bioethics
2. The Concept of Responsibility: Three Stages in Its Evolution within Bioethics
3. Bioethics for Whom?
4. Towards an Ethics of Blame

For more information and/or to receive a copy of the readings contact Barry Belmont at belmont@umich.edu or visit http://belmont.bme.umich.edu/bioethics-discussion-group/discussions/044-responsibility/.

Please read the blog responsibly: https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Thu, 02 Apr 2020 09:12:34 -0400 2020-04-07T19:00:00-04:00 2020-04-07T20:30:00-04:00 Off Campus Location The Bioethics Discussion Group Lecture / Discussion Responsibility
BME 500: Yannis Paulus (April 9, 2020 4:00pm) https://events.umich.edu/event/70074 70074-17507739@events.umich.edu Event Begins: Thursday, April 9, 2020 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: Online hosting procedure TBD.

Yannis M Paulus, MD, FACS, is a clinician scientist retina surgeon who directs a retinal optical imaging and laser lab. He is an Assistant Professor in the Department of Ophthalmology and Visual Sciences and Biomedical Engineering at the University of Michigan. He completed his undergraduate in chemistry and physics at Harvard University, medical school with a scholarly concentration in bioengineering and ophthalmology residency at Stanford University, and surgical and medical retina fellowship at Johns Hopkins University. His lab develops photoacoustic and molecular imaging of the retina and minimally traumatic retinal laser therapies. He has published over 90 peer-reviewed publications and started-up 3 companies to translate new technologies to patients to help treat and cure vision loss and blindness.

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Workshop / Seminar Mon, 06 Apr 2020 15:45:49 -0400 2020-04-09T16:00:00-04:00 2020-04-09T17:00:00-04:00 Off Campus Location Biomedical Engineering Workshop / Seminar BME Event
Master's Thesis Defense: Mingyang Wang (April 10, 2020 10:30am) https://events.umich.edu/event/73990 73990-18460430@events.umich.edu Event Begins: Friday, April 10, 2020 10:30am
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be held via Blue Jeans. It will be linked before.

BlueJeans: https://bluejeans.com/315155702

Objectives
We have developed a novel anti-vascular technique, termed photo-mediated ultrasound therapy (PUT), which utilizes nanosecond duration laser pulses synchronized with ultrasound bursts to remove microvasculature through cavitation. The objective of the current study is to explore the potential of PUT in removing cutaneous microvessels.

Methods
The auricular blood vessels of two New Zealand white rabbits were treated by PUT with a peak negative ultrasound pressure of 0.45 MPa at 0.5 MHz, and a laser fluence of 0.056 J/cm2 at 1064 nm for 10 minutes. Blood perfusion in the treated area was measured by a commercial laser speckle imaging (LSI) system before and immediately after treatment, as well as at one hour, three days, two weeks, and four weeks post treatment. Perfusion rates of 38 individual vessels from 4 rabbit ears were tracked during this time period for longitudinal assessment.

Results
The measured perfusion rates of the vessels in the treated areas, as quantified by the relative change in perfusion rate (RCPR), showed a statistically significant decrease for all time points post treatment (p<0.001). The mean decrease in perfusion is 50.79% immediately after treatment and is 32.14% at four weeks post treatment. Immediately after treatment, the perfusion rate decreased rapidly. Following this, there was a partial recovery in perfusion rate up to 3 days post treatment, then followed by a plateau in the perfusion from 3 days to 4 weeks.

Conclusions
The study demonstrated that a single PUT treatment could significantly reduce blood perfusion by 32.14% in the skin for up to 4 weeks. With unique advantages such as low laser fluence as compared with photothermolysis and agent-free treatment as compared with PDT, PUT holds potential to be developed into a new tool for the treatment of microvessels in the skin.

Keywords: laser; ultrasound; anti-vascular treatment; skin microvessels; photo-mediated ultrasound therapy

Chair: Dr. Xueding Wang

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Lecture / Discussion Fri, 27 Mar 2020 13:53:59 -0400 2020-04-10T10:30:00-04:00 2020-04-10T11:30:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
PhD Defense: Joel Tan (April 14, 2020 2:00pm) https://events.umich.edu/event/73953 73953-18443421@events.umich.edu Event Begins: Tuesday, April 14, 2020 2:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This PhD defense will be taking place via Blue Jeans. Link below.

Blue Jeans: https://bluejeans.com/304616213
Chair: Dr. Xueding Wang

Photoacoustic (PA) imaging is an emerging biomedical imaging modality that combines optical and ultrasound imaging technologies. PA imaging relies on the absorption of electromagnetic energy (usually in the form of visible or near-infrared light) leading to the generation of acoustic waves by thermoelastic expansion, which can be detected with an ultrasound detector. PA imaging can be used to detect endogenous chromophores such as deoxyhemoglobin and oxyhemoglobin, or can be used together with external nanosensors for added functionality. The former is used to measure things like blood oxygenation, while the latter opens up many possibilities for PA imaging, limited only to the availability of optical nanosensors. In this dissertation, I employ the use of PA nanosensors for contrast enhancement and molecular imaging in in vivo small animal cancer models.

In the first section, I introduce a novel PA background reduction technique called the transient triplet differential (TTD) method. The TTD method exploits the fact that phosphorescent dyes possess a triplet state with a unique red-shifted absorption wavelength, distinct from its ordinary singlet state absorption profile. By pumping these dyes into the triplet state and comparing the signal to the unpumped dyes, a differential signal can be obtained which solely originates from these dyes. Since intrinsic chromophores of biological tissue are not able to undergo intersystem crossing and enter the triplet state, the TTD method can facilitate “true” background free molecular imaging by excluding the signals from every other chromophore outside the phosphorescent dye. Here, I demonstrate up to an order of magnitude better sensitivity of the TTD method compared to other existing contrast enhancement techniques in both in vitro experiments and in vivo cancer models.

In the second section, I explore the use of a nanoparticle formulation of a repurposed FDA-approved drug called clofazimine for diagnosis of prostate cancer. Clofazimine nanoparticles have a high optical absorbance at 495 nm and has been known to specifically accumulate in macrophages as they form stable crystal-like inclusions once they are uptaken by macrophages. Due to the presence of tumor associated macrophages, it is expected that clofazimine would accumulate in much higher quantities in the cancerous prostate compared to normal prostates. Here, I show that there was indeed a significantly higher accumulation of clofazimine nanoparticles in cancerous prostates compared to normal prostates in a transgenic mouse model, which was detectable both using histology and ex vivo PA imaging.

In the third and final section, I explore the use of a potassium (K+) nanosensor together with PA imaging in measuring the in vivo K+ distribution in the tumor microenvironment (TME). K+ is the most abundant ion in the body and has recently been shown to be at a significantly higher concentration in the tumor. The reported 5-10 fold elevation (25-50 mM compared to 5 mM) in the tumor has been shown to inhibit immune cell efficacy, and thus immunotherapy. Despite the abundance and importance of K+ in the body, few ways exist to measure it in vivo. In this study, a solvatochromic dye K+ nanoparticle (SDKNP) was used together with PA imaging to quantitatively measure the in vivo distribution of K+ in the TME. Significantly elevated K+ levels were found in the TME, with an average concentration of approximately 29 mM, matching the values found by the previous study. The results were then verified using mass spectrometry.

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Lecture / Discussion Wed, 25 Mar 2020 13:19:15 -0400 2020-04-14T14:00:00-04:00 2020-04-14T15:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
BME 500: Lonnie Shea (April 16, 2020 4:00pm) https://events.umich.edu/event/70076 70076-17507740@events.umich.edu Event Begins: Thursday, April 16, 2020 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be hosted via Blue Jeans. The link will be provided below.

Blue Jeans Link: https://umich.bluejeans.com/902489900

The promise of precision health is typically associated with the early detection of disease, and the identification of an individually tailored therapy to extend healthspan while also reducing costs. I will discuss our work on immune engineering, as the immune system is essential to health, and consequently immune dysregulation can lead to disease. Autoimmune disease has been increasing in prevalence for the past few decades, and results from the immune system attacking healthy tissues, such as in Type 1 Diabetes or Multiple Sclerosis. Current treatments typically involve suppressing the entire immune system, despite the immune system attacking specific proteins. Based on the function of the immune system, we have developed nanoparticles that re-program immune responses to specific antigens leading to tolerance to those antigens and leaving the remainder of the immune system intact. The nanoparticles maintain the antigen until internalization by immune cells, with subsequent presentation of the antigen coincident with down-regulation of the co-stimulatory factors and up-regulation of negative co-stimulators. In addition to reprogramming specific immune responses, a need exists for technologies that can detect autoimmune disease initiation prior to substantial destruction of healthy tissues. We have applied tissue engineering principles to generate tissues subcutaneously that function as an immunological niche, which can be accessed easily to avoids risks associated with biopsy of native tissues (e.g., brain,) and thereby report on immune status within tissues. Technologies for detecting disease at the earliest stages combined with reprogramming specific cellular responses represent major opportunities for Precision Health to improve health while containing costs.

Speaker biography:

Lonnie Shea is the Chair of the Department of Biomedical Engineering at the University of Michigan (U-M), which is joint between the College of Engineering and the School of Medicine. He received his PhD in chemical engineering and scientific computing from U-M in 1997, working with Professor Jennifer Linderman. He then served as a postdoctoral fellow with then ChE Professor David Mooney in the Department of Biologic and Materials Science at the U-M Dental School. Shea was recruited to Northwestern University’s Department of Chemical and Biological Engineering and was on the faculty from 1999 to 2014. In 2014, Shea was recruited back to the University of Michigan as chair of the Department of Biomedical Engineering, with his recruitment coinciding with the endowment of the chair position by William and Valerie Hall. He is the Steven A. Goldstein Collegiate Professor of Biomedical Engineering and is an internationally recognized researcher at the interface of regenerative medicine, drug and gene delivery, and immune-engineering, whose focus is on preventing tissue degeneration or promoting tissue regeneration. His projects include islet transplantation for diabetes therapies, nerve regeneration for treating paralysis, autoimmune diseases and allogeneic cell transplantation, cancer diagnostics, and ovarian follicle maturation for treating infertility. He is currently PI or co-PI on 5 NIH grants (4R01’s, 1 R21). The nanoparticle technology for immune tolerance has led to the formation of a company that is leading a series of clinical trials. Shea has published more than 240 manuscripts, and has numerous inventions to his credit. He is the PI for the Coulter Foundation Translational Research grants committee at the University of Michigan. He served as director of Northwestern’s NIH Biotechnology Training Grant. He has received the Clemson Award from the Society for Biomaterials, is a fellow of the American Institute of Medical and Biological Engineering (AIMBE) and the Biomedical Engineering Society (BMES), a member of the editorial boards for multiple journals such as Molecular Therapy, Biotechnology and Bioengineering, and the Journal of Immunology and Regenerative Medicine.

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Workshop / Seminar Thu, 16 Apr 2020 13:10:30 -0400 2020-04-16T16:00:00-04:00 2020-04-16T17:00:00-04:00 Off Campus Location Biomedical Engineering Workshop / Seminar BME Event
Master's Defense: Jonathan Primeaux (April 21, 2020 2:30pm) https://events.umich.edu/event/74331 74331-18633862@events.umich.edu Event Begins: Tuesday, April 21, 2020 2:30pm
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be held via Zoom. The link will be placed below.

Zoom Link: https://umich.zoom.us/j/7013698675

Children with hypoplastic left heart syndrome (HLHS) must undergo multiple surgical stages to reconstruct the anatomy to a sustainable single ventricle system. Stage I palliation, or the Norwood procedure, enables circulation to both pulmonary and systemic vasculature. The aorta is reconstructed and attached to the right ventricle and a fraction of systemic flow is redirected to the pulmonary arteries (PAs) through a systemic-to-pulmonary artery shunt. Despite abundant hemodynamic data available 4-5 months after palliation, data is very scarce immediately following stage I. This data is critical in determining post-operative success. In this work, we combined population data and computational fluid dynamics (CFD) to characterize hemodynamics immediately following stage I (post-stage I) and prior to stage II palliation (pre-stage II). A patient-specific model was constructed as a baseline geometry, which was then scaled to reflect population-based morphological data at both time-points. Population-based hemodynamic data was also used to calibrate each model to reproduce blood flow representative of HLHS patients.

The post-stage I simulation produced a mean PA pressure of 22 mmHg and high-frequency oscillations within the flow field indicating highly disturbed hemodynamics. Despite mean PA pressure dropping to 14 mmHg, the pre-stage II model also produced high-frequency flow components and PA wall shear stress increases. These suboptimal conditions result from the need to ensure adequate PA flow throughout the pre-stage II period, as the shunt becomes relatively smaller compared to the growing patient size. In the future, CFD can be used to optimize shunt design and minimize these suboptimal conditions.

Chair: Dr. Alberto Figueroa

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Lecture / Discussion Fri, 17 Apr 2020 13:05:00 -0400 2020-04-21T14:30:00-04:00 2020-04-21T15:30:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Master's Defense: Xijia Quan (April 21, 2020 3:00pm) https://events.umich.edu/event/74183 74183-18559840@events.umich.edu Event Begins: Tuesday, April 21, 2020 3:00pm
Location:
Organized By: Biomedical Engineering

NOTICE: This event will be held via Blue Jeans. The link will be posted below.

Blue Jeans link: https://bluejeans.com/6788336326

We propose a novel optimization algorithm for radiofrequency (RF) pulse design in magnetic resonance imaging (MRI), that regularizes the magnitude and phase of the target (desired) magnetization pattern separately. This approach may be useful across applications where the relative importance of achieving accurate magnitude or phase excitation varies; for example, saturation pulses "care" only about the magnitude excitation pattern. We apply our new design to the problem of spin "prephasing" in 3D functional MRI using blood-oxygen-level-dependent (BOLD) contrast; spin prephasing pulses can mitigate the signal loss observed near air/tissue boundaries due to the presence of local susceptibility gradients. We show that our algorithm can improve the simulation performance and recover some signal in some regions with steep susceptibility gradients. In all cases, our algorithm shows better phase correction than a conventional design based on minimizing the complex difference between the target and realized patterns. The algorithm is open-source and the computation time is feasible for online applications. In addition, we evaluate the impact of the choice of (initial) excitation k-space trajectories, both in terms of trajectory type (SPINS vs extended KT points) and overall pulse duration.

Chair: Dr. Jon-Fredrik Nielsen

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Lecture / Discussion Thu, 09 Apr 2020 14:11:30 -0400 2020-04-21T15:00:00-04:00 2020-04-21T16:00:00-04:00 Biomedical Engineering Lecture / Discussion BME Logo
Bioethics Discussion: History (April 21, 2020 7:00pm) https://events.umich.edu/event/52731 52731-12974165@events.umich.edu Event Begins: Tuesday, April 21, 2020 7:00pm
Location: Off Campus Location
Organized By: The Bioethics Discussion Group

A discussion on the means to our ends.

NOTICE: Online hosting procedure https://bluejeans.com/7569798571.

Readings to consider:
1. Bioethics and History
2. The History of Bioethics: Its Rise and Significance
3. What can History do for Bioethics?
4. “My Story Is Broken; Can You Help Me Fix It?”: Medical Ethics and the Joint Construction of Narrative

For more information and/or to receive a copy of the readings contact Barry Belmont at belmont@umich.edu or visit http://belmont.bme.umich.edu/bioethics-discussion-group/discussions/045-history/.

Of historical note – the blog: https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Thu, 02 Apr 2020 09:22:43 -0400 2020-04-21T19:00:00-04:00 2020-04-21T20:30:00-04:00 Off Campus Location The Bioethics Discussion Group Lecture / Discussion History
PhD Defense: David Martel (April 22, 2020 3:00pm) https://events.umich.edu/event/74201 74201-18568320@events.umich.edu Event Begins: Wednesday, April 22, 2020 3:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be held via Zoom. The link will be provided below.

Zoom: https://umich.zoom.us/j/2019377962

Tinnitus is the disorder of phantom sound perception, while hyperacusis is abnormally increased loudness growth. Tinnitus and hyperacusis are both associated with hearing loss, but hearing loss does not always occur with either condition, implicating central neural activity as the basis for each disorder. Furthermore, while tinnitus and hyperacusis can co-occur, either can occur exclusively, suggesting that separate pathological neural processes underlie each disorder.

Mounting evidence suggests that pathological neural activity in the cochlear nucleus, the first central nucleus in the auditory pathway, underpins hyperacusis and tinnitus. The cochlear nucleus is comprised of a ventral and dorsal subdivision, which have separate principle output neurons with distinct targets. Previous studies have shown that dorsal cochlear nucleus fusiform cells show tinnitus-related increases in spontaneous firing with minimal alterations to sound-evoked responses. In contrast, sound-evoked activity in ventral cochlear nucleus bushy cells is enhanced following noise-overexposure, putatively underlying hyperacusis. While the fusiform-cell contribution to tinnitus has been well characterized with behavioral and electrophysiological studies, the bushy-cell contribution to tinnitus or hyperacusis has been understudied.

This dissertation examines how pathological neural activity in cochlear nucleus circuitry relates to tinnitus and hyperacusis in the following three chapters.

In the first chapter, I characterize the development of a high-throughput tinnitus behavioral model, which combines and optimizes existing paradigms. With this model, I show that animals administered salicylate, a drug that reliably induces tinnitus at high doses in both humans and animals, show behavioral evidence of tinnitus in two separate behavioral tests. Moreover, in these same animals, I show that dorsal-cochlear-nucleus fusiform cells exhibit frequency-specific increases in spontaneous firing activity, consistent with noise-induced tinnitus in animals.

In the second chapter, I show that following noise-overexposure, ventral-cochlear-nucleus bushy cells demonstrate hyperacusis-like neural firing patterns, but not tinnitus-specific increases in spontaneous activity. I contrast the bushy-cell neural activity with established fusiform-cell neural signatures of tinnitus, to highlight the bushy-cell, but not fusiform-cell contribution to hyperacusis. These analyses suggest that tinnitus and hyperacusis likely arise from distinct neural substrates.

In the third chapter, I use computational modelling of the auditory periphery and bushy-cell circuitry to examine potential mechanisms that underlie hyperacusis-like neural firing patterns demonstrated in the second chapter. I then relate enhanced bushy-cell firing patterns to alterations in the auditory brainstem response, a sound-evoked electrical potential generated primarily by bushy cells. Findings in this chapter suggest that there are multiple hyperacusis subtypes, arising from separate mechanisms, which could be diagnosed through fine-tuned alterations to the auditory brainstem response.

Chair: Dr. Susan Shore

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Lecture / Discussion Thu, 09 Apr 2020 14:17:07 -0400 2020-04-22T15:00:00-04:00 2020-04-22T16:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Project Management Certification (April 26, 2020 11:00am) https://events.umich.edu/event/73563 73563-18261074@events.umich.edu Event Begins: Sunday, April 26, 2020 11:00am
Location: Ross School of Business
Organized By: Tauber Institute for Global Operations

Once again, the Tauber Institute, in conjunction with the International Project Management Association (IPMA), is sponsoring a Project Management certification class and exam for graduate business and engineering students and staff.

In order to participate, you will need to reflect upon a project management experience (for example a work project, an engineering design experience/senior capstone, Ross' MAP project, Tauber team project, etc). If you cannot make it to the classes (due to project travel, MAP, or other another class), the sessions will be recorded. Homework (mastery verification) will be required after each session.

The cost to an individual to take the exam is normally $595, however, Tauber is offering the exam at a substantial discount to non-Tauber students: $500 and to Tauber students: $150. Certification is valid for 5 years. Three certification classes will be taught by Professor Eric Svaan on the following dates:

Sunday, March 15 (noon - 4:30 pm, Ross R-0420)
Sunday, March 29 (noon - 4:30 pm, Ross R-0420)
Sunday, April 5 (noon - 4:30 pm, Ross R-0420)

The certification exam, administered by IPMA-USA is scheduled for April 26, 2020 (11:00 am) at the Ross School of Business, R-0320. Successfully passing the exam will yield IPMA's Level D certification (Certified Project Management Associate).

Over the last two years, all students who have taken the exam have passed!

Project Management is a powerful skillset to have in your toolbox as you look for full-time employment!

REGISTRATION: Please register through iMpact by clicking here:
http://myumi.ch/dO5Nl

NOTE: The $500 (for non-Tauber students) or $150 fee (for Tauber students) is non-refundable.

HOSTED BY: Tauber Institute for Global Operations. For questions about this event, please contact tauberinstitute@umich.edu or visit tauber.umich.edu.

What is IPMA Level D® (Certified Project Management Associate)? The IPMA Level D is an internationally recognized entry-level qualification in the area of project management. This designation, which demonstrates the individual's ability to understand the basics of project management, is similar to the exam-oriented, knowledge-based certifications of other major Project Management associations. For many, Level D® is the first step towards a professional project or program manager role. It is the first step in a sequence (C, B, and A) to be earned by demonstration of success in larger PM responsibility sets.

For more information,
Visit tauber.umich.edu or call 734-647-1333
Connect via email to Diana Crossley dianak@umich.edu

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Class / Instruction Thu, 05 Mar 2020 10:07:18 -0500 2020-04-26T11:00:00-04:00 2020-04-26T16:30:00-04:00 Ross School of Business Tauber Institute for Global Operations Class / Instruction Photo of certificate
PhD Defense: Richard Youngblood (April 29, 2020 2:00pm) https://events.umich.edu/event/74358 74358-18666222@events.umich.edu Event Begins: Wednesday, April 29, 2020 2:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be held via Blue Jeans. The link will be posted below.

BlueJeans: https://bluejeans.com/855683101

Human pluripotent stem cells (hPSCs) differentiated into complex three-dimensional (3D) structures, referred to as ‘organoids’ due to their organ-like properties, offer ideal platforms to study human development, disease and regeneration. However, studying organ morphogenesis has been hindered by the lack of appropriate culture systems that can spatially enable cellular interactions that are needed for organ formation. Many organoid cultures rely on decellularized extracellular matrices as supportive scaffolds, which are often poorly chemically defined and allow only limited tunability and reproducibility. By contrast, engineered synthetic matrices can be tuned and optimized to mimic the embryo environment in order to enhance development and maturation of organoid cultures. Herein, this work primarily focuses on using synthetic polymer matrices to investigate how the design of biomaterials can guide key interactions guiding stem-cell decisions for the reproducible generation and control of organoid cultures.
Microporous biomaterials comprised of synthetic polymer materials were shown to guide the assembly of pancreatic progenitors into insulin-producing clusters that further developed into islet organoids. The scaffold culture facilitated cell-cell interactions enabled by the scaffold design and supported cell-mediated matrix deposition of extracellular matrix (ECM) proteins associated with the basement membrane of islet cells. Furthermore, when compared to suspension cultures, the scaffold culture showed increased insulin secretion in response to glucose stimulus indicating the development of functional β-cells. By modifying the stage that cells were seeded on scaffolds from pancreatic progenitor to pancreatic endoderm, islet organoids showed increased amounts of insulin secreted per cell. In addition, seeding scaffolds with dense clusters instead of a single suspension minimized cell manipulation during the differentiation, which was shown to be influential to the development of the islet organoids. An engineered insulin reporter further identified how mechanistic changes in vitro influenced function within individual cells by measuring insulin storage and secretion through non-invasive imaging.
hPSC-derived lung organoids (HLOs) were also evaluated for in vivo maturation on biomaterial scaffolds, where HLOs were shown improved tissue structure and cellular differentiation. Investigative studies demonstrated that scaffold pore interconnectivity and polymer degradation contributed to in vivo maturation, the size of the airway structures and the total size of the transplanted tissue. Polymer biomaterials were also developed to modulate local tissue and systemic inflammation through local delivery of human interleukin 4 (hIL-4)-expressing lentivirus. Microporous scaffold culture strategies improve organoid complexity and exert fine control over the system using engineering solutions, thus, allowing the community to build more realistic organoid tools. Taken together, the microporous scaffold culture demonstrates the feasibility to translate organoid culture to the clinic as a biomanufacturing platform.

Chair: Dr. Lonnie Shea

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Lecture / Discussion Tue, 21 Apr 2020 13:21:55 -0400 2020-04-29T14:00:00-04:00 2020-04-29T15:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Master's Defense: Manan Parag Anjaria (April 30, 2020 1:15pm) https://events.umich.edu/event/74435 74435-18714559@events.umich.edu Event Begins: Thursday, April 30, 2020 1:15pm
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be held via Blue Jeans. The link will be provided below.

Blue Jeans Link: https://bluejeans.com/126133694

Individual muscle contributions to facilitate limb motion are altered in people with transtibial amputation. Specifically, proximal muscles on the residual limb and muscles on the intact limb compensate for the lack of plantarflexor muscles on the residual limb. Powered ankle prostheses have been developed to replace the function of the ankle plantarflexor muscles. As powered prostheses can help people with amputation walk faster, and replicate local ankle joint mechanics similar to biological ankles, we expect that muscle activity would also differ when using powered prostheses compared to unpowered prosthesis. Exploring muscle synergies, or the patterns of co-activation of muscles recruited by a single neural command signal, can provide insight into the neural control strategies used to walk with different types of prostheses. The goal of this study was to determine if the use of a powered ankle prosthesis affected muscle coordination and coactivation in comparison to the use of unpowered prosthesis. Nine people with unilateral transtibial amputation and 9 age-matched, non-amputee controls walked on a treadmill while muscle activity from 16 lower limb muscles were collected. Participants with amputation performed two trials, one with an unpowered and one with a powered prosthesis, on the same day. People with transtibial amputation had higher thigh muscle co-contraction when walking with powered prostheses. They also had the same number of synergies in both prostheses as the non-amputee group, which suggests that the complexity of the motor control strategy is not affected by amputation or prosthesis type. The first three synergies in the intact limb were similar, however, the contribution of different muscles to the fourth synergy varied in people with amputation as they used more knee flexors than ankle dorsiflexors in the late swing phase. We also explored the time-varying pattern of the synergies across the gait cycle. There were some phases of the gait cycle where activation profiles for all the synergies were significantly different between the groups with and without amputation. However, there were strong correlations between muscle weightings for each synergy between the groups with and without amputation, with both prostheses. This indicates that they used a similar muscle recruitment strategy. The use of powered prosthesis reduced the compensatory activity of the proximal muscles making the intact limb synergies muscle weightings more similar to healthy individuals with prolonged or delayed activation profiles. The study could not offer any interpretations of the synergies of the residual limb due to lesser muscle activity data available. Future work should be focused including a larger set of muscles including the lumbar muscles and residual leg muscles to get a better look at the muscle synergy.

Chair: Dr. Deanna Gates

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Lecture / Discussion Mon, 27 Apr 2020 13:44:40 -0400 2020-04-30T13:15:00-04:00 2020-04-30T14:15:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
PhD Defense: Xianglong Wang (May 5, 2020 1:00pm) https://events.umich.edu/event/74357 74357-18666221@events.umich.edu Event Begins: Tuesday, May 5, 2020 1:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be via Zoom. The link will be provided below.

Zoom: https://umich.zoom.us/j/99315883529

Biological transport processes often involve a boundary acting as separation of flow, most commonly in transport involving blood-contacting medical devices. The separation of flow creates two different scenarios of mass transport across the interface. No flow exists within the medical device and diffusion governs mass transport; both convection and diffusion exist when flow is present. The added convection creates a large concentration gradient around the interface. Computer simulation of such cases prove to be difficult and require proper shock capturing methods for the solutions to be stable, which is typically lacking in commercial solvers. In this talk, we propose a second-order accurate numerical method for solving the convection-diffusion equation by using a gradient-limited Godunov-type convective flux and the multi-point flux approximation (MPFA) L-Method for the diffusion flux. We applied our solver towards simulation of a nitric oxide-releasing intravascular catheter.

Intravascular catheters are essential for long-term vascular access in both diagnosis and treatment. Use of catheters are associated with risks for infection and thrombosis. Risk management dictates that the catheters to be often replaced on a 3 to 5-day cycle, which is bothersome to both patients and physicians. Nitric oxide (NO) is a potent antimicrobial and antithrombotic agent produced by vascular endothelial cells. The production level in vivo is so low that the physiological effects can only be seen around the endothelial cells. The catheter can incorporate a NO source in two major ways: by impregnating the catheter with NO-releasing compounds such as S-nitroso-N-acetyl penicillamine (SNAP) or using electrochemical reactions to generate NO from nitrites. We applied our solver to both situations to guide the design of the catheter.

Lung edema is often present in patients with end-stage renal disease due to reduced filtration functions of the kidney. These patients require regular dialysis sessions to manage their fluid status. The clinical gold standard to quantify lung edema is to use CT, which exposes patients to high amounts of radiation and is not cost efficient. Fluid management in such patients becomes very challenging without a clear guideline of fluid to be removed during dialysis sessions. Aggressive fluid removal can cause both exacerbations of congestive failure and hypotension resulting from low blood volume.

Recently, reverberations in ultrasound signals, referred to as “lung ultrasound comets” have emerged as a potential quantitative way to measure lung edema. Increased presence of lung comets is associated with higher amounts of pulmonary edema, higher mortality, and more adverse cardiac events. However, the lung comets are often counted by hand by physicians with single frames in lung ultrasound and high subjectivity has been found to exist among the counting by physicians. We applied image processing and neural network techniques as an attempt to provide an objective and accurate measurement of the amount of lung comets present. Our quantitative results are significantly correlated with a few clinical parameters, including diastolic blood pressure and ejection fraction.

Co-Chairs: Dr. Joseph Bull and Dr. Alberto Figueroa

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Lecture / Discussion Tue, 21 Apr 2020 13:16:12 -0400 2020-05-05T13:00:00-04:00 2020-05-05T14:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Ph.D. Defense: Kevin Hughes (May 8, 2020 10:00am) https://events.umich.edu/event/74436 74436-18714560@events.umich.edu Event Begins: Friday, May 8, 2020 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be held via Blue Jeans. The link will be provided below.

Blue Jeans Link: https://bluejeans.com/302652230

A variety of immunological disorders are characterized by inappropriate responses to innocuous protein. This is particularly relevant in autoimmune disease, allergy, and transplant rejection. For these, the therapeutic options that exist are minimal or involve broadly immunosuppressive regimens which are often characterized by undesirable side effects. This dissertation highlights advances in the design of a biodegradable poly-lactide-co-glycolide (PLG) nanoparticle (NP) platform to provide antigen-specific tolerance in these disease models.

Strategies to incorporate multiple antigens conjugated to bulk PLG were investigated in a murine model of multiple sclerosis with the observation that a minimum antigen loading of 8µg of antigen per mg of nanoparticle was sufficient to induce maximally observed efficacy. Insights gathered from development of these particles were critical to the design of experiments related to food allergy in mice. Importantly, we demonstrate that it is possible to delivery peanut extract via nanoparticles intravenously without induction of anaphylactic response. Prophylactic and therapeutic administration of particles resulted in improved clinical outcomes and reduction in Th2 markers, including IL-4, IL-5, and IL-13. Interestingly, administration of PLG NPs to deliver allergen did not induce skewing of immunological responses towards Th1/Th17, which is a common approach to treat allergy in pre-clinical models and certain clinical immunotherapy regimens. Studies in a murine model of allogeneic skin transplant rejection demonstrated that the method of incorporation of antigen into the PLG NP resulted in statistically significant delay in graft rejection. These studies also demonstrated shortcomings in the platform’s ability to completely prevent rejection, which we hypothesize is the result of an inability to prevent direct rejection.

Development of FasL-conjugated implantable polymeric discs provided an immunologically privileged site on which to transplant islet cells, which may represent an opportunity to supplement tolerogenic therapies like our PLG NPs. A similar polymeric, implantable technology was designed to enable analysis of the function of inflammatory immune cells, a novel finding which has provided a method to monitor disease progression and response to therapy in a murine model of multiple sclerosis. Collectively, this work has provided several novel strategies to improve polymeric nanoparticle therapies and an implantable, biodegradable platform that shows promise as a companion diagnostic for therapies that impact immune function, including PLG NPs.

Chair: Dr. Lonnie Shea

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Lecture / Discussion Mon, 27 Apr 2020 13:54:09 -0400 2020-05-08T10:00:00-04:00 2020-05-08T11:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Virtual Seminar - "Metabolic engineering strategies: from static to dynamic rewiring of microbial metabolic networks” (June 1, 2020 10:00am) https://events.umich.edu/event/74728 74728-18952538@events.umich.edu Event Begins: Monday, June 1, 2020 10:00am
Location: Off Campus Location
Organized By: Life Sciences Institute (LSI)

Filipa Pereira, Ph.D.
Postdoctoral Fellow
European Molecular Biology Laboratory

Link to attend: https://umich.zoom.us/j/93168574796

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Lecture / Discussion Wed, 27 May 2020 10:54:07 -0400 2020-06-01T10:00:00-04:00 2020-06-01T11:00:00-04:00 Off Campus Location Life Sciences Institute (LSI) Lecture / Discussion
Webinar: Learning Health Systems in the Time of COVID-19 (June 2, 2020 2:00pm) https://events.umich.edu/event/74564 74564-18825099@events.umich.edu Event Begins: Tuesday, June 2, 2020 2:00pm
Location:
Organized By: Department of Learning Health Sciences

This 90-minute webinar is designed to introduce individuals to the overall concept of learning health systems, focusing on core components of learning cycles and infrastructure. It is appropriate for anyone interested in how health systems function, and particularly for individuals working within health systems. We will use examples that span countries and clinical problems, with special emphasis on the SARS-CoV-2 pandemic.

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Lecture / Discussion Mon, 11 May 2020 11:05:21 -0400 2020-06-02T14:00:00-04:00 2020-06-02T15:30:00-04:00 Department of Learning Health Sciences Lecture / Discussion Corona virus and Collaboratory logo
RNA Innovation Seminar, Jeffery Twiss, MD, PhD, Professor, Interim Departmental Chair, SmartState Chair in Childhood Neurotherapeutics, University of South Carolina (June 15, 2020 4:00pm) https://events.umich.edu/event/73583 73583-18263274@events.umich.edu Event Begins: Monday, June 15, 2020 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Jeffery Twiss, MD, PhD, Professor, Interim Departmental Chair, SmartState Chair in Childhood Neurotherapeutics, University of South Carolina

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Lecture / Discussion Thu, 05 Mar 2020 08:43:23 -0500 2020-06-15T16:00:00-04:00 2020-06-15T17:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion lecture
Using Precision Health resources to empower your COVID-19 research (June 25, 2020 10:30am) https://events.umich.edu/event/74897 74897-19065439@events.umich.edu Event Begins: Thursday, June 25, 2020 10:30am
Location: Off Campus Location
Organized By: Precision Health

How to use Precision Health resources (MGI and more) to empower your COVID-19 research


COVID-19 is the most urgent health crisis of our generation, and we will be studying it for decades to come. Join us for a one-hour workshop to explore:
• Data available on coronavirus testing and diagnoses
• Data available on demographics, comorbidities, medications, and other clinical information related to health outcomes
• Data available on genotypes for >70,000-participant MGI cohort
• Tools and services available to you for accessing and analyzing data

The workshop will be led by Erin O’Brien Kaleba, MPH, Director, Data Office for Clinical & Translational Research.

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Livestream / Virtual Wed, 10 Jun 2020 13:32:07 -0400 2020-06-25T10:30:00-04:00 2020-06-25T11:30:00-04:00 Off Campus Location Precision Health Livestream / Virtual Empower your research with PH resources
PhD Defense: Matthew S. Willsey (June 29, 2020 10:00am) https://events.umich.edu/event/74994 74994-19128257@events.umich.edu Event Begins: Monday, June 29, 2020 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be held via Zoom. The link will be placed below.

Zoom: https://umich.zoom.us/j/91278019863

Many diseases and injuries irreparably harm the brain or spinal cord and result in motor paralysis, widespread sensory deficits, and pain. Often, there are no treatments for these injuries, and therapies revolve around rehabilitation and adapting to the acquired deficits. In this work, we investigate brain machine interfaces (BMIs) as a future therapy to restore sensorimotor function, use BMIs to understand sensorimotor circuits, and use novel imaging algorithms to assess structural damage of somatosensory inputs into the brain.

Brain-controlled robotic arms have progressed rapidly from the first prototype devices in animals; however, these arms are often slow-moving compared to normal hand and arm function. In the first study, we attempt to restore higher-velocity movements during real-time control of virtual fingers using a novel feedforward neural network algorithm to decode the intended motor movement from the brain. In a non-human primate, the neural network decoder was compared with a linear decoder, the ReFIT Kalman filter (RFKF), that we believe represents the state-of-the-art in real-time finger decoding. The neural network decoder outperformed RFKF by acquiring more targets at faster velocities. This neural network architecture may also provide a blueprint for additional advances.

Somatosensory feedback from robotic arms is an important step to improve the realism and overall functioning. The use of somatosensory thalamus was investigated as a site of implantation for a sensory prosthesis in subjects undergoing awake deep brain stimulation surgery (DBS). In this study, electrical stimulation of the thalamus was performed using different stimulation patterns and the evoked sensations were compared. We found that the sensations evoked by bursting (a burst of pulses followed by a rest period) and tonic (regularly repeating pulses) stimulation were often in different anatomic regions and often with differing sensory qualities. These techniques for controlling percept location and quality may be useful in not only in BMI applications but also in DBS therapies to better relieve symptoms and avoid unwanted side effects.

Given the importance of sensory integration in motor functioning, the third study investigated the impact of a pharmacological perturbation on somatosensory content in primary motor cortex measured with Utah arrays implanted in two NHPs. Specifically, during continuous administration of nitrous oxide (N2O), somatosensory content was assessed by using the neural activity in primary motor cortex to classify finger brushings with a cotton-tip applicator. N2O degraded but did not eliminate somatosensory content in motor cortex. These findings provide insight into N2O mechanisms and may lead to further study of somatosensory afferents to motor cortex.

A debilitating facial pain syndrome, called trigeminal neuralgia (TN), is thought to be caused by vascular compression of the sensory root that provides somatosensory feedback from the face. In this final study, magnetic resonance diffusion tensor imaging was used to assess the structural damage of this sensory root. In a retrospective manner, we developed and tested an algorithm that predicted the likelihood of pain relief after surgical treatment of TN. This algorithm could help select patients for surgery with the best chance for pain relief.

Together, these studies advance BMI technologies that attempt to restore realistic function to those with irreparable damage to sensorimotor pathways. Furthermore, using BMIs and novel imaging, this work provides a better understanding of sensorimotor circuits and how sensory pathways can be damaged in disease states.

Co-Chairs: Parag G. Patil and Cynthia A. Chestek

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Lecture / Discussion Thu, 18 Jun 2020 15:24:23 -0400 2020-06-29T10:00:00-04:00 2020-06-29T11:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
PhD Defense: Daniel Quevedo (July 1, 2020 9:30am) https://events.umich.edu/event/74977 74977-19118435@events.umich.edu Event Begins: Wednesday, July 1, 2020 9:30am
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be held digitally via Blue Jeans. The link will be placed below.

BlueJeans: https://bluejeans.com/863787871

Nanomedicine- where a therapeutic is loaded into nanoparticles to increase therapeutic efficiency and improve patient outcomes- has long had the potential to revolutionize medicine. With all of their promise, nanoparticle carrier technologies have yet to make a significant clinical impact, emphasizing the need for new technologies and approaches. In this dissertation, electrohydrodynamic (EHD) co-jetting was used to develop various methods to create novel Synthetic Protein Nanoparticles (SPNPs), which were then applied to the delivery of therapeutic enzymes, and characterized using a microfluidic technique. It was found that SPNPs can be made from various proteins, such as Human Transferrin, Hemoglobin, and others, and that various macromers can be selected, such as a stimuli responsive NHS-Ester based macromer that can detect oxidative environments and show signs of degradation within 30 minutes of being taken up by HeLa cells. SPNPs were then loaded with medically relevant enzymes, such as the antioxidant enzyme catalase. The enzymes showed high activity retention rates, with catalase SPNPs maintaining up to 82% of their original enzymatic activity. Additionally, antibody-targeted catalase SPNPs were able to protect up to 80% of REN cells in an inflammatory disease model. Next, an electrokinetic microfluidic system was adapted for the characterization of SPNPs based on their protein composition and anisotropy, and was able to differentiate bicompartmental particles made from two different proteins from single compartment SPNPs made of an equivalent isotropic mixture of the same two proteins, with a voltage difference of 900 V between the two particle types, in contrast to the 50 V step sizes possible in these systems. Finally, preliminary work was conducted on using a small targeting molecule, meta-acetylenbenzylguanidine (MABG), for the treatment of neuroblastoma, and a system for validating MABG targeting in SK-N-BE(2) cells (a neuroblastoma cell line) was developed. Work done in this dissertation presents the development of multifunctional protein nanocarriers and lays the groundwork for the targeted delivery of active therapeutics using these particles.

Chair: Dr. Joerg Lahann

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Lecture / Discussion Thu, 18 Jun 2020 15:24:54 -0400 2020-07-01T09:30:00-04:00 2020-07-01T10:30:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
BioTalk (July 10, 2020 3:00pm) https://events.umich.edu/event/75131 75131-19279360@events.umich.edu Event Begins: Friday, July 10, 2020 3:00pm
Location: Off Campus Location
Organized By: Futures in Research, Science, Teaching - FIRST

BioTalk seminars provide speakers with experience presenting their research to a broader audience, including researchers and students from other departments. Each seminar is a 20 minute talk followed by 10 minutes of Q&A. Speakers will share a general statement of their research project and a background paper before their talk and will receive feedback on their presentation though an online form.

Please contact biotalk.contact@umich.edu if you would like to give a talk.

The BioTalk workshop is available to undergraduates interested in learning more about bioscience research at the graduate level. Students who participate in four workshops will receive a certificate of completion. These workshops include submitting questions prior to the talk, providing feedback to the presenter through an online form, and writing a short reflection on the content of the talk, including a researched description of one of the experimental techniques used by the speaker in their research project (or their shared publication).

Please see web link section for BioTalk schedule and workshop sign-up.

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Workshop / Seminar Tue, 07 Jul 2020 18:21:28 -0400 2020-07-10T15:00:00-04:00 2020-07-10T16:00:00-04:00 Off Campus Location Futures in Research, Science, Teaching - FIRST Workshop / Seminar BioTalk
BioArtography Virtual Art Fair Sale through July 21! (July 16, 2020 12:00am) https://events.umich.edu/event/75240 75240-19342129@events.umich.edu Event Begins: Thursday, July 16, 2020 12:00am
Location: Off Campus Location
Organized By: BioArtography

BioArtography is having a Virtual Art Fair through July 21! An exciting collection of new images for 2020 will be launched & returning favorites are still available!

Specials will be offered on our website bioartography.com including 15% off and free U.S. shipping on note cards, prints, framed art, gallery wrap canvas and frameless glass!

Follow @bioartography on Twitter , Instagram and Facebook to keep up with all the details!

Proceeds from the sale of this work help support the training of our next generation of researchers!

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Exhibition Mon, 20 Jul 2020 12:13:02 -0400 2020-07-16T00:00:00-04:00 2020-07-16T23:59:00-04:00 Off Campus Location BioArtography Exhibition BioArtography 2020 Collection
BioArtography Virtual Art Fair Sale through July 21! (July 17, 2020 12:00am) https://events.umich.edu/event/75240 75240-19342130@events.umich.edu Event Begins: Friday, July 17, 2020 12:00am
Location: Off Campus Location
Organized By: BioArtography

BioArtography is having a Virtual Art Fair through July 21! An exciting collection of new images for 2020 will be launched & returning favorites are still available!

Specials will be offered on our website bioartography.com including 15% off and free U.S. shipping on note cards, prints, framed art, gallery wrap canvas and frameless glass!

Follow @bioartography on Twitter , Instagram and Facebook to keep up with all the details!

Proceeds from the sale of this work help support the training of our next generation of researchers!

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Exhibition Mon, 20 Jul 2020 12:13:02 -0400 2020-07-17T00:00:00-04:00 2020-07-17T23:59:00-04:00 Off Campus Location BioArtography Exhibition BioArtography 2020 Collection
BioArtography Virtual Art Fair Sale through July 21! (July 18, 2020 12:00am) https://events.umich.edu/event/75240 75240-19342131@events.umich.edu Event Begins: Saturday, July 18, 2020 12:00am
Location: Off Campus Location
Organized By: BioArtography

BioArtography is having a Virtual Art Fair through July 21! An exciting collection of new images for 2020 will be launched & returning favorites are still available!

Specials will be offered on our website bioartography.com including 15% off and free U.S. shipping on note cards, prints, framed art, gallery wrap canvas and frameless glass!

Follow @bioartography on Twitter , Instagram and Facebook to keep up with all the details!

Proceeds from the sale of this work help support the training of our next generation of researchers!

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Exhibition Mon, 20 Jul 2020 12:13:02 -0400 2020-07-18T00:00:00-04:00 2020-07-18T23:59:00-04:00 Off Campus Location BioArtography Exhibition BioArtography 2020 Collection
BioArtography Virtual Art Fair Sale through July 21! (July 19, 2020 12:00am) https://events.umich.edu/event/75240 75240-19342132@events.umich.edu Event Begins: Sunday, July 19, 2020 12:00am
Location: Off Campus Location
Organized By: BioArtography

BioArtography is having a Virtual Art Fair through July 21! An exciting collection of new images for 2020 will be launched & returning favorites are still available!

Specials will be offered on our website bioartography.com including 15% off and free U.S. shipping on note cards, prints, framed art, gallery wrap canvas and frameless glass!

Follow @bioartography on Twitter , Instagram and Facebook to keep up with all the details!

Proceeds from the sale of this work help support the training of our next generation of researchers!

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Exhibition Mon, 20 Jul 2020 12:13:02 -0400 2020-07-19T00:00:00-04:00 2020-07-19T23:59:00-04:00 Off Campus Location BioArtography Exhibition BioArtography 2020 Collection
BioArtography Virtual Art Fair Sale through July 21! (July 20, 2020 12:00am) https://events.umich.edu/event/75240 75240-19379434@events.umich.edu Event Begins: Monday, July 20, 2020 12:00am
Location:
Organized By: BioArtography

BioArtography is having a Virtual Art Fair through July 21! An exciting collection of new images for 2020 will be launched & returning favorites are still available!

Specials will be offered on our website bioartography.com including 15% off and free U.S. shipping on note cards, prints, framed art, gallery wrap canvas and frameless glass!

Follow @bioartography on Twitter , Instagram and Facebook to keep up with all the details!

Proceeds from the sale of this work help support the training of our next generation of researchers!

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Exhibition Mon, 20 Jul 2020 12:13:02 -0400 2020-07-20T00:00:00-04:00 2020-07-20T23:59:00-04:00 BioArtography Exhibition BioArtography 2020 Collection
BioArtography Virtual Art Fair Sale through July 21! (July 21, 2020 12:00am) https://events.umich.edu/event/75240 75240-19379435@events.umich.edu Event Begins: Tuesday, July 21, 2020 12:00am
Location:
Organized By: BioArtography

BioArtography is having a Virtual Art Fair through July 21! An exciting collection of new images for 2020 will be launched & returning favorites are still available!

Specials will be offered on our website bioartography.com including 15% off and free U.S. shipping on note cards, prints, framed art, gallery wrap canvas and frameless glass!

Follow @bioartography on Twitter , Instagram and Facebook to keep up with all the details!

Proceeds from the sale of this work help support the training of our next generation of researchers!

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Exhibition Mon, 20 Jul 2020 12:13:02 -0400 2020-07-21T00:00:00-04:00 2020-07-21T23:59:00-04:00 BioArtography Exhibition BioArtography 2020 Collection
PhD Defense: Charles Lu (July 23, 2020 2:00pm) https://events.umich.edu/event/75199 75199-19324453@events.umich.edu Event Begins: Thursday, July 23, 2020 2:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be held via Zoom. The link will be placed below.

Zoom: https://umich-health.zoom.us/j/95667535536

Therapeutic neuromodulation has an established history for clinical indications, such as deep brain stimulation for movement disorders and spinal cord stimulation for pain, despite an incomplete understanding of its mechanism of action. Novel neuroprosthetics have the potential to enable wholly new therapies, including sensory restoration and treatment of affective disorders. In order to fully realize the potential of these interventions, precise parameterization of stimulation, informed by better understanding of underlying processes, is required. This dissertation explores the temporal and spatial determinants of outcomes for stimulation within the context of clinical and experimental sensorimotor neuromodulation.

The first study of the dissertation defines a new functional target for subthalamic deep brain stimulation for Parkinson disease treatment. While optimal sites of stimulation are often analyzed as discrete points in space, therapeutic tissue activation is known to activate entire volumes of surrounding tissue. To identify markers of these volumes, we used machine learning tools to identify associations between features of wideband neural recordings and regions of clinically validated stimulation regions derived from patient-specific tissue activation models. The study identified several electrophysiological markers of therapeutic activation regions, providing a tool for efficient optimization of stimulation programming.

Despite the importance of spatially precise stimulation, conventional stereotactic methods are limited by intrinsic sources of error. The second study assessed a novel form of lead localization utilizing local impedance at deep brain sites. We demonstrated that in vivo impedance measurements generally match patterns observed in electrostatic simulations and showed that these values can be efficiently estimated using diffusion tensor data. Impedances measured using a clinical macroelectrode provided spatial information at the resolution of millimeters and could be used to roughly localize deep brain trajectories, presenting a prototype method to complement existing targeting technologies.

The final study evaluated a novel form of deep brain stimulation for modulation of pain. Previous rodent studies show that stimulation of zona incerta can provide analgesic effect, and clinical evidence suggests that stimulation of a nearby nucleus, nominally used to treat motor manifestations of Parkinson disease, often also results in improvement of pain symptoms. We directly tested the analgesic effect of zona incerta stimulation in humans and demonstrated that stimulation at the physiological spiking frequency of zona incerta selectively reduces perceived heat pain.

Chair: Dr. Parag G. Patil

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Lecture / Discussion Mon, 13 Jul 2020 15:30:00 -0400 2020-07-23T14:00:00-04:00 2020-07-23T15:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
BioTalk (July 24, 2020 3:00pm) https://events.umich.edu/event/75131 75131-19279361@events.umich.edu Event Begins: Friday, July 24, 2020 3:00pm
Location:
Organized By: Futures in Research, Science, Teaching - FIRST

BioTalk seminars provide speakers with experience presenting their research to a broader audience, including researchers and students from other departments. Each seminar is a 20 minute talk followed by 10 minutes of Q&A. Speakers will share a general statement of their research project and a background paper before their talk and will receive feedback on their presentation though an online form.

Please contact biotalk.contact@umich.edu if you would like to give a talk.

The BioTalk workshop is available to undergraduates interested in learning more about bioscience research at the graduate level. Students who participate in four workshops will receive a certificate of completion. These workshops include submitting questions prior to the talk, providing feedback to the presenter through an online form, and writing a short reflection on the content of the talk, including a researched description of one of the experimental techniques used by the speaker in their research project (or their shared publication).

Please see web link section for BioTalk schedule and workshop sign-up.

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Workshop / Seminar Tue, 07 Jul 2020 18:21:28 -0400 2020-07-24T15:00:00-04:00 2020-07-24T16:00:00-04:00 Futures in Research, Science, Teaching - FIRST Workshop / Seminar BioTalk
PhD Defense: Benjamin Juliar (July 28, 2020 1:00pm) https://events.umich.edu/event/75205 75205-19330337@events.umich.edu Event Begins: Tuesday, July 28, 2020 1:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be held via BlueJeans. The link will be placed below.

BlueJeans Link: https://bluejeans.com/358462383

Engineering large viable tissues requires techniques for encouraging rapid capillary bed formation to prevent necrosis. A convenient means of creating this micro-vascular network is through spontaneous neovascularization, which occurs when endothelial cells (ECs) and supportive stromal cells are co-encapsulated within a variety of hydrogel-based extracellular matrices (ECM) and self-assemble into an interconnected network of endothelial tubules. Although this is a robust phenomenon, the environmental and cell-specific determinants that affect the rate and quality of micro-vascular network formation still require additional characterization to improve clinical translatability. This thesis investigates how the proteolytic susceptibility of engineered matrices effects neovascular self-assembly in poly(ethylene glycol) (PEG) hydrogels and provides characterization of changes to matrix mechanics that accompany neovascular morphogenesis in fibrin and PEG hydrogels.

Proteolytic ECM remodeling is essential for the process of capillary morphogenesis. Pharmacological inhibitor studies suggested a role for both matrix metalloproteinases (MMP)- and plasmin-mediated mechanisms of ECM remodeling in an EC-fibroblast co-culture model of vasculogenesis in fibrin. To further investigate the potential contribution of plasmin mediated matrix degradation in facilitating capillary morphogenesis we employed PEG hydrogels engineered with proteolytic specificity to either MMPs, plasmin, or both. Although fibroblasts spread in plasmin-selective hydrogels, we only observed robust capillary morphogenesis in MMP-sensitive matrices, with no added benefit in dual susceptible hydrogels. Enhanced capillary morphogenesis was observed, however, in PEG hydrogels engineered with increased susceptibility to MMPs without altering proteolytic selectivity or hydrogel mechanical properties. These findings highlight the critical importance of MMP-mediated ECM degradation during vasculogenesis and justify the preferential selection of MMP-degradable peptide crosslinkers in the design of synthetic hydrogels used to promote vascularization.

Matrix stiffness is a well-established cue in cellular morphogenesis, however, the converse effect of cellular remodeling on environmental mechanics is comparatively under characterized. In fibrin hydrogels, we applied traditional bulk rheology and laser tweezers-based active microrheology to demonstrate that both ECs and fibroblasts progressively stiffen the ECM across length scales, with the changes in bulk properties dominated by fibroblasts. Despite a lack of fibrillar architecture, a similar stiffening effect was observed in MMP-degradable PEG hydrogels. This stiffening tightly correlated with degree of vessel formation and critically depended on active cellular contractility. To a lesser degree, deposition of ECM proteins also appeared to contribute to progressive hydrogel stiffening. Blocking cell-mediated hydrogel degradation abolished stiffening, demonstrating that matrix metalloproteinase (MMP)-mediated remodeling is required for stiffening to occur. EC co-culture with mesenchymal stem cells (MSCs) in PEG resulted in reduced vessel formation compared to fibroblast co-cultures and no change in hydrogel mechanics over time. The correlation between matrix stiffening and enhanced vessel formation, and dependence on cellular contractility, suggests differences in vessel formation between fibroblasts and MSCs may be partially mediated by differences in cellular contractility. Collectively, these findings provide a deeper understanding of mechanobiological effects during capillary morphogenesis and highlight the dynamic reciprocity between cells and their mechanical environment.

Chair: Dr. Andrew Putnam

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Lecture / Discussion Tue, 14 Jul 2020 11:02:36 -0400 2020-07-28T13:00:00-04:00 2020-07-28T14:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
PhD Defense: Katy Norman (July 30, 2020 10:00am) https://events.umich.edu/event/75267 75267-19395124@events.umich.edu Event Begins: Thursday, July 30, 2020 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be held via BlueJeans. The link will be posted below.

BlueJeans: https://bluejeans.com/516255948

Mucosal surfaces in the lung interface with the outside environment for breathing purposes, but also provide the first line of defense against invading pathogens. The intricate balance of effective immune protection at the pulmonary epithelium without problematic inflammation is not well understood, but is an important consideration in complex lung diseases such as idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD). Although IPF is a fibrotic interstitial lung disease of unknown origin and COPD is an obstructive lung disease, they do share some similarities. Both are heterogeneous and progressive in nature, have no cure and few treatment options, advance through unknown mechanisms, and involve an aberrant immune response. As research has focused into the role the immune system plays in IPF and COPD, it has become clear that disease progression is caused by a complex dysregulation of immune factors and cells across the tissue compartments of the lungs and blood.

Data-driven modeling approaches offer the opportunity to infer protein interaction networks, which are able to identify diagnostic and prognostic biomarkers and also serve as the basis for new insight into systems-level mechanisms that define a disease state. Additionally, these approaches are able to integrate data from across multiple tissue compartments, allowing for a more holistic picture of a disease to be formed. Here, we have applied data-driven modeling approaches including partial least squares discriminant analysis, principal component analysis, decision tree analysis, and hierarchical clustering to high-throughput cell and cytokine measurements from human blood and lung samples to gain systems-level insight into IPF and COPD.

Overall we found that these approaches were useful for identifying signatures of proteins that differentiated disease state and progression better than current classifiers. We also found that integrating protein and cell measurements across tissue compartments generally improved classification and was useful for generating new mechanistic insight into progression and exacerbation events. In evaluating IPF progression, we showed that the blood proteome of progressors, but not of non-progressors, changes over time, and that our data-driven modeling techniques were able to capture these changes. Curiously, our models showed that complement system components may be associated with both COPD and IPF disease progression. Lastly, though our analysis suggested that circulating blood cytokines were not useful for differentiating disease state or progression, preliminary work suggested that cell-cell communication networks arising from stimulated peripheral blood proteins may be more useful for classification and gaining mechanistic insight from minimally invasive blood samples. Overall, we believe that this approach will be useful for studying the mucosal immune response present in other diseases that are also progressive or heterogeneous in nature.

Chair: Dr. Kelly Arnold

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Lecture / Discussion Wed, 22 Jul 2020 16:19:44 -0400 2020-07-30T10:00:00-04:00 2020-07-30T11:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
PhD Defense: Josiah Simeth (August 5, 2020 2:00pm) https://events.umich.edu/event/75278 75278-19402991@events.umich.edu Event Begins: Wednesday, August 5, 2020 2:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Notice: This event will be held via BlueJeans. The link will be placed below.

BlueJeans: https://bluejeans.com/715371816

Measures of regional and global liver function are critical in guiding treatments for intrahepatic cancers, and liver function is a dominant factor in the survival of patients with hepatocellular carcinoma (HCC). Global and regional liver function assessments are important for defining the magnitude and spatial distribution of radiation dose to preserve functional liver parenchyma and reduce incidence of hepatotoxicity from radiation therapy (RT) for intrahepatic cancer treatment. This individualized liver function-guided RT strategy is critical for patients with heterogeneous and poor liver function, often observed in cirrhotic patients treated for HCC. Dynamic gadoxetic-acid enhanced (DGAE) magnetic resonance imaging (MRI) allows investigation of liver function through observation of the uptake of contrast agent into the hepatocytes.

This work seeks to determine if gadoxetic uptake rate can be used as a reliable measure of liver function, and to develop robust methods for uptake estimation with an interest in the therapeutic application of this knowledge in the case of intrahepatic cancers. Since voxel-by voxel fitting of the preexisting nonlinear dual-input two-compartment model is highly susceptible to over fitting, and highly dependent on data that is both temporally very well characterized and low in noise, this work proposes and validates a new model for quantifying the voxel-wise uptake rate of gadoxetic acid as a measure of regional liver function. This linearized single-input two-compartment (LSITC) model is a linearization of the pre-existing dual-input model but is designed to perform uptake quantification in a more robust, computationally simpler, and much faster manner. The method is validated against the preexisting dual-input model for both real and simulated data. Simulations are used to investigate the effects of noise as well as issues related to the sampling of the arterial peak in the characteristic input functions of DGAE MRI.

Further validation explores the relationship between gadoxetic acid uptake rate and two well established global measures of liver function, namely: Indocyanine Green retention (ICGR) and Albumin-Bilirubin (ALBI) score. This work also establishes the relationships between these scores and imaging derived measures of whole liver function using uptake rate. Additionally, the same comparisons are performed for portal venous perfusion, a pharmacokinetic parameter that has been observed to correlate with function, and has been used as a guide for individualized liver function-guided RT. For the patients assessed, gadoxetic acid uptake rate performs significantly better as a predictor of whole liver function than portal venous perfusion.
This work also investigates the possible gains that could be introduced through use of gadoxetic uptake rate maps in the creation of function-guided RT plans. To this end, plans were created using both perfusion and uptake, and both were compared to plans that did not use functional guidance. While the plans were generally broadly similar, significant differences were observed in patients with severely compromised uptake that did not correspond with compromised perfusion.

This dissertation also deals with the problem of quantifying uptake rate in suboptimal very temporally sparse or short DGAE MRI acquisitions. In addition to testing the limits of the LSITC model for these limited datasets (both realistic and extreme), a neural network-based approach to quantification of uptake rate is developed, allowing for increased robustness over current models.

Chair: Dr. Yue Cao

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Lecture / Discussion Thu, 23 Jul 2020 17:51:41 -0400 2020-08-05T14:00:00-04:00 2020-08-05T15:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
BioTalk (August 7, 2020 3:00pm) https://events.umich.edu/event/75131 75131-19279362@events.umich.edu Event Begins: Friday, August 7, 2020 3:00pm
Location: Off Campus Location
Organized By: Futures in Research, Science, Teaching - FIRST

BioTalk seminars provide speakers with experience presenting their research to a broader audience, including researchers and students from other departments. Each seminar is a 20 minute talk followed by 10 minutes of Q&A. Speakers will share a general statement of their research project and a background paper before their talk and will receive feedback on their presentation though an online form.

Please contact biotalk.contact@umich.edu if you would like to give a talk.

The BioTalk workshop is available to undergraduates interested in learning more about bioscience research at the graduate level. Students who participate in four workshops will receive a certificate of completion. These workshops include submitting questions prior to the talk, providing feedback to the presenter through an online form, and writing a short reflection on the content of the talk, including a researched description of one of the experimental techniques used by the speaker in their research project (or their shared publication).

Please see web link section for BioTalk schedule and workshop sign-up.

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Workshop / Seminar Tue, 07 Jul 2020 18:21:28 -0400 2020-08-07T15:00:00-04:00 2020-08-07T16:00:00-04:00 Off Campus Location Futures in Research, Science, Teaching - FIRST Workshop / Seminar BioTalk
BioTalk (August 21, 2020 3:00pm) https://events.umich.edu/event/75131 75131-19279363@events.umich.edu Event Begins: Friday, August 21, 2020 3:00pm
Location: Off Campus Location
Organized By: Futures in Research, Science, Teaching - FIRST

BioTalk seminars provide speakers with experience presenting their research to a broader audience, including researchers and students from other departments. Each seminar is a 20 minute talk followed by 10 minutes of Q&A. Speakers will share a general statement of their research project and a background paper before their talk and will receive feedback on their presentation though an online form.

Please contact biotalk.contact@umich.edu if you would like to give a talk.

The BioTalk workshop is available to undergraduates interested in learning more about bioscience research at the graduate level. Students who participate in four workshops will receive a certificate of completion. These workshops include submitting questions prior to the talk, providing feedback to the presenter through an online form, and writing a short reflection on the content of the talk, including a researched description of one of the experimental techniques used by the speaker in their research project (or their shared publication).

Please see web link section for BioTalk schedule and workshop sign-up.

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Workshop / Seminar Tue, 07 Jul 2020 18:21:28 -0400 2020-08-21T15:00:00-04:00 2020-08-21T16:00:00-04:00 Off Campus Location Futures in Research, Science, Teaching - FIRST Workshop / Seminar BioTalk
PhD Defense: Ziwen Zhu (August 26, 2020 9:30am) https://events.umich.edu/event/75720 75720-19576537@events.umich.edu Event Begins: Wednesday, August 26, 2020 9:30am
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be held via Zoom. The link will be placed below.

Zoom: umich.zoom.us/j/92149340369

Branched Chain amino acids (BCAAs) play an essential role in cell metabolism supplying both carbon and nitrogen in pancreatic cancers, and their increased levels have been associated with increased risk of pancreatic ductal adenocarcinomas (PDACs). It remains unclear how stromal cells regulate BCAA metabolism in PDAC cells and how mutualistic determinants control BCAA metabolism in the tumor milieu. In chapter 1, we present an overview of PDAC biology, tumor microenvironment (TME), altered cancer metabolism and BCAA metabolism. In chapter 2, we uncover differential gene expression of enzymes involved in BCAA metabolism accompanied by distinct catabolic, oxidative, and protein turnover fluxes between cancer-associated fibroblasts (CAFs) and cancer cells with a marked branched-chain keto acids (BCKA)-addiction in PDAC cells. In chapter 3, we showed that cancer-induced stromal reprogramming fuels this BCKA-addiction. We then show the functions of BCAT2 and DBT in the PDAC cells in chapters 3 and 4. We identify BCAT1 as the BCKA regulator in CAFs in chapter 5. In chapter 6, we dictated the internalization of the extracellular matrix from the tumor microenvironment to supply amino acid precursors for BCKA secretion by CAFs. We also showed that the TGF-β/SMAD5 axis directly targets BCAT1 in CAFs in chapter 7. In chapter 8, we validate the in vitro results in human patient-derived circulating tumor cells (CTCs) model. Furthermore, the same results were also validated in PDAC tissue slices, which recapitulate tumor heterogeneity and mimic the in vivo microenvironment in chapter 9. We conclude this manuscript with chapter 10 in which we propose future studies and present directions towards pancreatic cancer research. In summary, our findings reveal therapeutically actionable targets in stromal and cancer cells to regulate the symbiotic BCAA coupling among the cellular constituents of the PDAC microenvironment.

Chair: Dr. Deepak Nagrath

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Lecture / Discussion Fri, 14 Aug 2020 12:02:15 -0400 2020-08-26T09:30:00-04:00 2020-08-26T10:30:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
BME Seminar Series: Ben Cosgrove (September 3, 2020 4:00pm) https://events.umich.edu/event/75894 75894-19623813@events.umich.edu Event Begins: Thursday, September 3, 2020 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Join us for our virtual seminar series on Thursdays from 4-5pm!
These events will take place on BlueJeans at this link: https://bluejeans.com/628109990

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Workshop / Seminar Thu, 20 Aug 2020 14:01:44 -0400 2020-09-03T16:00:00-04:00 2020-09-03T17:00:00-04:00 Off Campus Location Biomedical Engineering Workshop / Seminar BME
EER Seminar Series (September 9, 2020 3:30pm) https://events.umich.edu/event/76055 76055-19661498@events.umich.edu Event Begins: Wednesday, September 9, 2020 3:30pm
Location: Off Campus Location
Organized By: Engineering Education Research

There is a significant knowledge gap regarding factors that influence the participation of Black and Hispanic women in computer science, and Dr. Ross has engaged in research to address this gap. She works to critically examine efforts and initiatives that aim to broaden participation in computer science by listening to voices of individuals who are often unheard. The outcomes of Dr. Ross’ research have the potential to reshape the community’s perceptions of what and who are computer scientists, and as well as to crack the code to diversifying this lucrative and impactful discipline. This talk will describe Dr. Ross’ research journey and will present preliminary results.

BIOGRAPHICAL SKETCH: Monique Ross, Assistant Professor in the School of Computing & Information Sciences and in the STEM Transformation Institute at Florida International University, earned a Ph.D. in Engineering Education from Purdue University. She has a B.S. degree in Computer Engineering from Elizabethtown College, an M.S. degree in Computer Science & Software Engineering from Auburn University, eleven years of experience in industry as a software engineer, and four years of experience as a full-time faculty member in computer science and engineering. Dr. Ross’ interests focus on broadening participation in computing through the exploration of: 1) race, gender, and identity in the academy and industry; and 2) discipline-based education research (with a focus on computer science and computer engineering courses) in order to inform pedagogical practices that garner interest and retain women and minorities in computer-related engineering fields. She was awarded the prestigious NSF CAREER award, and she uses her scholarship to challenge the perceptions of who belongs in computing.

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Lecture / Discussion Tue, 25 Aug 2020 09:42:16 -0400 2020-09-09T15:30:00-04:00 2020-09-09T16:30:00-04:00 Off Campus Location Engineering Education Research Lecture / Discussion Monique Ross, Florida International University
DCMB / CCMB Weekly Seminar Series (September 9, 2020 4:00pm) https://events.umich.edu/event/76946 76946-19780535@events.umich.edu Event Begins: Wednesday, September 9, 2020 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract: Birth defects that interfere with craniofacial development can result in cognitive, neurosensory, and neuroendocrine defects that create life-long burdens for care. The forebrain, midbrain, hindbrain, five facial prominences, and pituitary gland develop between the first and second month of gestation in humans. Genetic defects that disrupt these processes cause a spectrum of disorders that range from holoprosencephaly (HPE) and septo-optic dysplasia (SOD) to pituitary hormone deficiencies. We screened a large cohort of Argentinean patients with congenital hypopituitarism and related disorders for mutations in known genes and identified novel pathogenic variants and examples of digenic disease. However, the majority of patients did not receive a molecular diagnosis, indicating the high degree of genetic complexity underlying these disorders and the need for additional gene discovery. The majority of known hypopituitarism genes were discovered through basic research in pituitary cell lines and mutant mice. To identify novel regulatory genes for pituitary organogenesis we analyzed differential binding of a key pituitary-specific transcription factor, POU1F1, in cell lines that represent pituitary progenitors and differentiated cells. We discovered that POU1F1 binding is associated with bZIP transcription factors in progenitors and with bHLH factors in differentiated cells. We also applied single cell RNA sequencing technology to analyze gene expression during pituitary organogenesis and discovered novel transcription factors that are candidates for driving cell specification as well as unique, rare cell types that are likely differentiation intermediates. Bioinformatic analyses have played key roles in advancing our knowledge of neuroendocrine birth defects and normal pituitary organogenesis.

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Lecture / Discussion Wed, 09 Sep 2020 08:26:42 -0400 2020-09-09T16:00:00-04:00 2020-09-09T17:00:00-04:00 Off Campus Location DCMB Seminar Series Lecture / Discussion Sally Camper, Ph.D., Margery Shaw Distinguished University Professor of Human Genetics, Professor of Internal Medicine, University of Michigan
RNA Collaborative Seminar featuring: Sue Hammoud, Human Genetics & Justin Colacino, Environmental Health Sciences (September 9, 2020 4:00pm) https://events.umich.edu/event/75865 75865-19615931@events.umich.edu Event Begins: Wednesday, September 9, 2020 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

ZOOM REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_GjVNcoWtRG6OkzxSDmfb8A

"Same Same Different: Single cell RNAseq identifies conserved and divergent features of mammalian spermatogenesis"
Sue Hammoud, Ph.D.
Assistant Professor of Human Genetics
Website: https://hammoud.lab.medicine.umich.edu/

~and~

"Single cell transcriptomic profiling to understand breast stem cell heterogeneity in development and cancer disparities"
Justin Colacino. Ph.D.
Assistant Professor of Environmental Health Sciences
Website: https://www.colacinolab.com/

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Lecture / Discussion Wed, 26 Aug 2020 11:44:32 -0400 2020-09-09T16:00:00-04:00 2020-09-09T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion RNA Collaborative
BME Seminar Series: Ranu Jung (September 10, 2020 4:00pm) https://events.umich.edu/event/75902 75902-19623820@events.umich.edu Event Begins: Thursday, September 10, 2020 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Join us for our virtual seminar series on Thursdays from 4-5pm!
These events will take place on BlueJeans at this link: https://bluejeans.com/628109990

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Workshop / Seminar Thu, 20 Aug 2020 13:36:24 -0400 2020-09-10T16:00:00-04:00 2020-09-10T17:00:00-04:00 Off Campus Location Biomedical Engineering Workshop / Seminar BME
Identifying Emergency Funds and How to Advocate for Making Room in Your Financial Aid Package (September 11, 2020 2:00pm) https://events.umich.edu/event/75507 75507-19513173@events.umich.edu Event Begins: Friday, September 11, 2020 2:00pm
Location: Off Campus Location
Organized By: CEW+

Advance registration is required; look for the Zoom link at the bottom of your confirmation email after registering.

This session will provide information about how you can seek emergency funds should you experience an emergency situation or one-time, unusual, unforeseen expense while in school. Information about the types of situations that qualify for emergency funds and where to seek funding will be covered during this presentation.

RSVP HERE: http://www.cew.umich.edu/events/identifying-emergency-funds-and-how-to-advocate-for-making-room-in-your-financial-aid-package

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Livestream / Virtual Tue, 18 Aug 2020 14:02:34 -0400 2020-09-11T14:00:00-04:00 2020-09-11T15:00:00-04:00 Off Campus Location CEW+ Livestream / Virtual A jar of spilled change
Bioethics Discussion: The Theory of Mind (September 15, 2020 7:00pm) https://events.umich.edu/event/58827 58827-14563718@events.umich.edu Event Begins: Tuesday, September 15, 2020 7:00pm
Location: Lurie Biomedical Engineering
Organized By: The Bioethics Discussion Group

A discussion on what we think others think.

A few readings we will consider:
––Theory of Mind
––Theory of mind: The state of the art
––Theory of Mind and the Self
––Why psychological accounts of personal identity can accept a brain death criterion and biological definition of death

For more information and/or to receive a copy of the readings visit: http://belmont.bme.umich.edu/bioethics-discussion-group/discussions/046-the-theory-of-mind/.

––

While people are still allowed on campus, discussions will be held on the front lawn of Lurie Biomedical Engineering building. Participants will be asked to enter the area via a “welcome desk” where there will be hand sanitizer, wipes, etc. Participants will be masked, at least 12 feet from one another, and speaking through megaphones with one another. In accordance with public health mandates and guidance, participation will be limited to 20 individuals who sign up to participate ahead of time.

Sign up here: https://belmont.bme.umich.edu/ask-your-questions-to-ponder/

––
I have a theory you wouldn't mind the blog: https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Tue, 25 Aug 2020 11:08:46 -0400 2020-09-15T19:00:00-04:00 2020-09-15T20:30:00-04:00 Lurie Biomedical Engineering The Bioethics Discussion Group Lecture / Discussion The Theory of Mind
Biomedical Engineering Virtual Career Fair (September 16, 2020 9:00am) https://events.umich.edu/event/76028 76028-19655361@events.umich.edu Event Begins: Wednesday, September 16, 2020 9:00am
Location: Off Campus Location
Organized By: Engineering Career Resource Center

Hosted by: Biomedical Engineering Department and Beta Mu Epsilon
Date: September 16, 2020 (9 AM-5 PM ET)
The Biomedical Engineering Career Fair will be held virtually through Career Fair Plus on September 16, 2020, from 9 AM-5 PM ET. The Career Fair Plus platform will allow candidates to connect with recruiters via video in pre-scheduled time slots. The Career Fair is a great way to connect with employers recruiting students studying Biomedical Engineering for full-time, internship and co-op positions. Students may sign-up to meet with employers beginning on Sept. 9 at 12 PM ET! Check out the BME Career Fair Student Guide for more information, including details regarding how to schedule appointments with recruiters during the BME Career Fair.

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Careers / Jobs Mon, 07 Sep 2020 17:56:24 -0400 2020-09-16T09:00:00-04:00 2020-09-16T17:00:00-04:00 Off Campus Location Engineering Career Resource Center Careers / Jobs BME Career Fair
BME Seminar Series: Orlando Hoilett (September 17, 2020 4:00pm) https://events.umich.edu/event/75903 75903-19623821@events.umich.edu Event Begins: Thursday, September 17, 2020 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Join us for our virtual seminar series on Thursdays from 4-5pm!
These events will take place on BlueJeans at this link: https://bluejeans.com/628109990

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Workshop / Seminar Thu, 20 Aug 2020 13:51:27 -0400 2020-09-17T16:00:00-04:00 2020-09-17T17:00:00-04:00 Off Campus Location Biomedical Engineering Workshop / Seminar BME
DCMB / CCMB Weekly Virtual Seminar featuring Gioele La Manno, Ph.D. (EPFL Life Sciences Early Independent Research Scholar (ELISIR) (September 18, 2020 12:00pm) https://events.umich.edu/event/77057 77057-19836073@events.umich.edu Event Begins: Friday, September 18, 2020 12:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

I will present our comprehensive single-cell transcriptome atlas of mouse brain development spanning from gastrulation to birth. In this atlasing effort, we identified almost a thousand distinct cellular states, including the initial emergence of the neuroepithelium, different glioblasts, and a rich set of region-specific secondary organizers that we localize spatially. In this context, I will provide an example of how the spatially-resolved transcriptomic data can be particularly useful to interpret the complexity of such complex atlases.

Continuing in this direction, I will show the approach that we recently proposed as a general way to spatially resolve different types of next-generation sequencing data. We designed an imaging-free framework to localize high throughput readouts within a tissue by combining compressive sampling and image reconstruction. Our first implementation of this framework transformed a low-input RNA sequencing protocol into an imaging-free spatial transcriptomics technique (STRP-seq).

Finally, I will showcase the technique with the profiling of the brain of the Australian bearded dragon Pogona vitticeps. With this analysis, we revealed the molecular anatomy of the telencephalon of this lizard and provided evidence for a marked regionalization of the reptilian pallium and subpallium.

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Lecture / Discussion Wed, 16 Sep 2020 11:27:53 -0400 2020-09-18T12:00:00-04:00 2020-09-18T13:00:00-04:00 Off Campus Location DCMB Seminar Series Lecture / Discussion Gioele La Manno, Ph.D. (EPFL Life Sciences Early Independent Research Scholar (ELISIR) École polytechnique fédérale de Lausanne ‐ EPFL Swiss Federal Institute of Technology Lausanne)
FIRST Mass Meeting (September 20, 2020 6:00pm) https://events.umich.edu/event/76584 76584-19871824@events.umich.edu Event Begins: Sunday, September 20, 2020 6:00pm
Location:
Organized By: Futures in Research, Science, Teaching - FIRST

FIRST is a group of undergrads, grad students, and postdocs in the sciences. The goal of our org is to prepare undergrads for the grad school application process and research at the graduate level.

FIRST Sign-Up: https://forms.gle/bDBuue63ZhbtZvpg9

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Rally / Mass Meeting Sun, 20 Sep 2020 18:11:50 -0400 2020-09-20T18:00:00-04:00 2020-09-20T18:30:00-04:00 Futures in Research, Science, Teaching - FIRST Rally / Mass Meeting FIRST Logo
RNA Seminar featuring: Andrey Krasilnikov, Penn State (September 21, 2020 4:00pm) https://events.umich.edu/event/75802 75802-19608017@events.umich.edu Event Begins: Monday, September 21, 2020 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

ZOOM REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_obckKUCLT4mXI7kPskzc-Q

KEYWORDS: Ribozymes, RNase P, RNase MRP, ribonucleoprotein complexes, RNA-driven protein remodelling

ABSTRACT: Ribonuclease (RNase) P is a ribozyme-based catalytic ribonucleoprotein complex involved primarily in the maturation of tRNA in all three domains of life. In the course of evolution, the size and complexity of RNase P grew as the catalytic RNA moiety recruited additional protein components. In eukaryotes, the RNase P lineage has split, giving rise to a related RNP enzyme called RNase MRP, which shares multiple structural features (including most of the protein components) with the eukaryotic RNase P, but has a distinct and non-overlapping specificity. We report the recently solved cryo-EM structure of the 450 kDa yeast RNase MRP holoenzyme and compare it with the structure of its progenitor RNP, RNase P. We show that, surprisingly, several of the proteins shared by RNase MRP and RNase P undergo RNA-driven structural remodeling, allowing the same proteins to function in distinct structural contexts. This remodeling, combined with altered peripheral RNA elements, results in the functional diversification of the two closely related RNPs, in spite of the structural conservation of the nearly identical catalytic cores, demonstrating structural underpinnings of the acquisition of new functions by catalytic RNPs.

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Lecture / Discussion Thu, 17 Sep 2020 07:12:03 -0400 2020-09-21T16:00:00-04:00 2020-09-21T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Andrey Krasilnikov, Penn State
2020 Precision Health Virtual Symposium (September 23, 2020 8:45am) https://events.umich.edu/event/75090 75090-19216540@events.umich.edu Event Begins: Wednesday, September 23, 2020 8:45am
Location: Off Campus Location
Organized By: Precision Health

Join us for a full-day virtual event celebrating and exploring the latest research in the fast-moving, multidisciplinary field of precision health.

This year's event focuses on the engagement of community participants to do research and the positive impact research can have on communities. Featuring national and local experts from engineering, medicine, nursing, pharmacy, public health, and many other areas, this event will provide thought-provoking sessions from multiple perspectives.

The morning session is geared toward researchers, with speakers sharing best practices and the importance of engaging a community. The afternoon session will be appropriate for both research participants and researchers, as we focus on the impact of research on community. You may attend either or both sessions. All are welcome.

A virtual poster session will feature work by funded Precision Health Investigators and other invited research groups.

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Livestream / Virtual Mon, 24 Aug 2020 14:37:59 -0400 2020-09-23T08:45:00-04:00 2020-09-23T15:15:00-04:00 Off Campus Location Precision Health Livestream / Virtual 2020 Precision Health Virtual Symposium
EER Seminar Series (September 23, 2020 3:30pm) https://events.umich.edu/event/77085 77085-19796480@events.umich.edu Event Begins: Wednesday, September 23, 2020 3:30pm
Location: Off Campus Location
Organized By: Engineering Education Research

Much of the conversation on equity and inclusion centers on the need to “increase” something—the marginalized student population, mentoring programs, engagement opportunities, “knowledge” of topics like white privilege. However, few conversations focus on a much harder truth—that the culture of whiteness and maleness in engineering limits sustained improvement in equity and inclusion efforts of most institutions. Using preliminary findings from their current NSF-funded project called “I-MATTER,” Drs. Masta and Pawley examine how engineering culture has normalized racism and sexism for underrepresented students in engineering contexts. Through their discussion, they will highlight the strong need for more BIPOC (Black, Indigenous, and People of Color) researchers in white spaces, and encourage white researchers to “stay in their lanes” when approaching equity and inclusion research.

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Lecture / Discussion Mon, 21 Sep 2020 09:15:05 -0400 2020-09-23T15:30:00-04:00 2020-09-23T16:30:00-04:00 Off Campus Location Engineering Education Research Lecture / Discussion Drs. Stephanie Masta & Alice Pawley
DCMB / CCMB Weekly Virtual Seminar (September 23, 2020 4:00pm) https://events.umich.edu/event/77143 77143-19798542@events.umich.edu Event Begins: Wednesday, September 23, 2020 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Talk title: Decision Support System Applications in Dentistry

Dr. Lucia Cevidanes is the Thomas and Doris Graber Professor of Dentistry and Associate Professor at the Department of Orthodontics at the University of Michigan, and a Diplomate of the American Board of Orthodontics. She is a practicing clinician who has published over 150 manuscripts on 3D imaging for which she has received research grants from the American Association of Orthodontics Foundation and the National Institute of Dental and Craniofacial Research. Her work has been recognized by the American Association of Orthodontists Thomas M. Graber Award, the B F Dewel Award, Milo Hellman Award, and the Wuehrmann award from the American Academy of Oral and Maxillofacial Radiology. Her interests include Artificial Intelligence and 3D Imaging to solve difficult clinical problems in dentistry, studying current and new treatment approaches and technical procedures, and understanding treatment outcomes for craniofacial anomalies and dentofacial deformities.

Zoom Link: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Lecture / Discussion Fri, 11 Sep 2020 15:27:53 -0400 2020-09-23T16:00:00-04:00 2020-09-23T17:00:00-04:00 Off Campus Location DCMB Seminar Series Lecture / Discussion Dr. Lucia Cevidanes is the Thomas and Doris Graber Professor of Dentistry and Associate Professor at the Department of Orthodontics at the University of Michigan
Hanley, Flight & Zimmerman Information Session, Hosted by TBP (September 23, 2020 5:30pm) https://events.umich.edu/event/77102 77102-19796508@events.umich.edu Event Begins: Wednesday, September 23, 2020 5:30pm
Location: Off Campus Location
Organized By: Tau Beta Pi

We are a boutique patent law firm located in the heart of Chicago and we practice patent prosecution and counseling for large Fortune 500 companies. Learn about Patent Law and the role of an engineer at a patent law firm.

Join Recruitment Manager, Bill O'Connor, and HFZ Patent Agent and U of M Biomedical Engineering Alumnus, Sophia Pilipchuk, in a discussion exploring the role of an engineer working at a professional patent law office. How are your engineering skills utilized in this unique career path and what is the trajectory of a patent engineer in the Intellectual Property industry? Interested in being exposed to the latest cutting edge technology? All will be discussed at this information session.

Handshake RSVP Link: https://app.joinhandshake.com/events/570177

Positions Recruiting: Full-time, Intern
Degrees Recruiting: Bachelor’s, Master’s, Ph.D.
Majors Recruiting: Biomedical Engineering, Computer Engineering, Computer Science, Electrical Engineering, Mechanical Engineering
Citizenship Requirements: U.S. Citizenship or Permanent Resident
Collecting Resumes: Yes

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Careers / Jobs Fri, 11 Sep 2020 11:45:44 -0400 2020-09-23T17:30:00-04:00 2020-09-23T18:30:00-04:00 Off Campus Location Tau Beta Pi Careers / Jobs
U-M BME Virtual Graduate Program Fair (September 24, 2020 10:00am) https://events.umich.edu/event/77635 77635-19893775@events.umich.edu Event Begins: Thursday, September 24, 2020 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

In this Virtual Fair event, we will share with you what is great about BME at the University of Michigan and your options for graduate studies. With our top-tier medical and engineering program, there is a broad set of opportunities for participating in cutting edge research across a spectrum of disciplines! This event will also include panel discussions with current faculty and current graduate students, giving you a forum for asking questions about our programs. We look forward to welcoming you to this event!

Presentation open to students interested in: PhD, Master's

Meeting Room Link: https://umich-health.zoom.us/j/94033188012?pwd=V2xHclpXWTV4a1BBSFVneEhaa0ZMdz09
Meeting ID#: 940 3318 8012
Meeting Passcode: 925334

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Other Wed, 23 Sep 2020 15:03:01 -0400 2020-09-24T10:00:00-04:00 2020-09-24T11:30:00-04:00 Off Campus Location Biomedical Engineering Other BME Event
Postdoc Appreciation Seminars at the School of Dentistry (September 24, 2020 12:00pm) https://events.umich.edu/event/77254 77254-19828126@events.umich.edu Event Begins: Thursday, September 24, 2020 12:00pm
Location: Off Campus Location
Organized By: Office of Research School of Dentistry

Jessica A. Ferreira – Bottino Lab
Jingwen Yang – Mishina Lab
Veronica Mendoza-Reinoso – McCauley/Roca Lab

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Lecture / Discussion Tue, 15 Sep 2020 09:49:10 -0400 2020-09-24T12:00:00-04:00 2020-09-24T13:00:00-04:00 Off Campus Location Office of Research School of Dentistry Lecture / Discussion flyer
BME Seminar Series: Jane Grande-Allen (September 24, 2020 4:00pm) https://events.umich.edu/event/75904 75904-19623822@events.umich.edu Event Begins: Thursday, September 24, 2020 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Join us for our virtual seminar series on Thursdays from 4-5pm!
These events will take place on BlueJeans at this link: https://bluejeans.com/628109990

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Workshop / Seminar Thu, 20 Aug 2020 13:53:40 -0400 2020-09-24T16:00:00-04:00 2020-09-24T17:00:00-04:00 Off Campus Location Biomedical Engineering Workshop / Seminar BME
RNA Seminar featuring: Hiroaki Suga, University of Tokyo (September 28, 2020 9:00am) https://events.umich.edu/event/75805 75805-19608020@events.umich.edu Event Begins: Monday, September 28, 2020 9:00am
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

ZOOM REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_PBHPayAvR8WobaSf3z0AUA

ABSTRACT: Macrocyclic peptides possess a number of pharmacological characteristics distinct from other well-established therapeutic molecular classes, resulting in a versatile drug modality with a unique profile of advantages. Macrocyclic peptides are accessible by not only chemical synthesis but also ribosomal synthesis. Particularly, recent inventions of the genetic code reprogramming integrated with an in vitro display format, referred to as RaPID (Random non-standard Peptides Integrated Discovery) system, have enabled us to screen mass libraries (>1 trillion members) of non-standard peptides containing multiple non-proteinogenic amino acids, giving unique properties of peptides distinct from conventional peptides, e.g. greater proteolytic stability, higher affinity (low nM to sub nM dissociation constants similar to antibodies), and superior pharmacokinetics. The field is rapidly growing evidenced by increasing interests from industrial sectors, including small start-ups as well as mega-pharmas, toward drug development efforts on macrocyclic peptides, which has led to several de novo discovered peptides entering clinical trials. This lecture discusses the aforementioned screening technology involving the method of “genetic code reprogramming” powered by flexizymes, and several showcases of therapeutic potentials of macrocyclic peptides.

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Lecture / Discussion Sun, 20 Sep 2020 13:22:07 -0400 2020-09-28T09:00:00-04:00 2020-09-28T10:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Hiroaki Suga, University of Tokyo
Saltiel Life Sciences Symposium 2020 (September 29, 2020 2:00pm) https://events.umich.edu/event/72207 72207-19655364@events.umich.edu Event Begins: Tuesday, September 29, 2020 2:00pm
Location: Off Campus Location
Organized By: Life Sciences Institute (LSI)

The 2020 Saltiel Life Sciences Symposium will explore innovative and creative research already taking place using unique model systems, and consider all we have yet to learn from the innumerable unexplored model systems — many of which are disappearing at alarming rates as a result of global climate change.

Schedule: Tuesday, September 29

2:00 p.m. | Welcome

Talk Session 1: Human Adaptation and Evolution
2:10 p.m. | Mary Sue and Kenneth Coleman Life Sciences Lecture — Genomic evolution and adaptation in Africa: Implications for health and disease
Sarah A. Tishkoff, Ph.D.
David and Lyn Silfen University Professor, Departments of Genetics and Biology; Director, Center for Global Genomics & Health Equity, Department of Genetics, Perelman School of Medicine, University of Pennsylvania

Talk Session 2: Social Biomimicry
3:10 p.m. | Towards living robots: Using biology to make better machines (full lecture)
Barry A. Trimmer, Ph.D.
Henry Bromfield Pearson Professor of Natural Sciences; Director, Neuromechanics and Biomimetic Devices Laboratory, Tufts University

4:05 p.m. | How the physics of slithering can teach multilegged robots to walk (short talk)
Shai Revzen, Ph.D.
Assistant Professor, Electrical Engineering and Computer Science, University of Michigan

4:25 p.m. | What wasps can teach us about the evolution of animal minds (full lecture)
Elizabeth Tibbetts, Ph.D.
Professor, Associate Chair for Research Facilities, Ecology and Evolutionary Biology, University of Michigan

5:20 p.m. | Day 1 Closing Remarks


Schedule: Wednesday, September 30

9:00 a.m. | Welcome

Talk Session 3: Biological Control of Disease Vectors
9:05 a.m. | Breaking up Anopheles-Plasmodium interactions for malaria control (full lecture)
Flaminia Catteruccia, Ph.D.
Professor, Immunology and Infectious Disease, Harvard University

10:00 a.m. | Cryopreservation of multicellular animals: Lessons from extreme insects (short talk)
Nicholas Teets, Ph.D.
Assistant Professor, Department of Entomology, University of Kentucky

10:20 a.m. | Break

10:35 a.m. | Transgenic fungi for mosquito control (full lecture)
Raymond St. Leger, Ph.D.
Professor, Entomology, University of Maryland

11:30 a.m. | Recombination versus mutation as the fuel for rapid evolution across the fungal tree of life (short talk)
Timothy James, Ph.D.
Associate Professor, Lewis E. Wehmeyer and Elaine Prince Wehmeyer Professor in the Taxonomy of Fungi, Ecology and Evolutionary Biology, University of Michigan

11:50 a.m. | Building a moving wall: Maintaining cell wall polarity during tip growth (short talk)
Cora MacAlister, Ph.D.
Assistant Professor, Department of Molecular, Cellular, and Developmental Biology, University of Michigan

12:10 p.m. | Closing remarks

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Conference / Symposium Wed, 09 Sep 2020 16:23:00 -0400 2020-09-29T14:00:00-04:00 2020-09-29T17:30:00-04:00 Off Campus Location Life Sciences Institute (LSI) Conference / Symposium Saltiel Life Sciences Symposium: Biodiversity in Biological Research
Bioethics Discussion: Artificial Intelligence (September 29, 2020 7:00pm) https://events.umich.edu/event/58828 58828-14563719@events.umich.edu Event Begins: Tuesday, September 29, 2020 7:00pm
Location: Lurie Biomedical Engineering
Organized By: The Bioethics Discussion Group

A discussion on how we know machines know.

Here are a few readings to consider:
––Ethical Issues of Artificial Intelligence in Medicine
––Regulatory responses to medical machine learning
––Will artificial intelligence solve the human resource crisis in healthcare?
––Medical ethics considerations on artificial intelligence

For more information and/or to receive a copy of the readings visit http://belmont.bme.umich.edu/bioethics-discussion-group/discussions/047-artificial-intelligence/.

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While people are still allowed on campus, discussions will be held on the front lawn of Lurie Biomedical Engineering building. Participants will be asked to enter the area via a “welcome desk” where there will be hand sanitizer, wipes, etc. Participants will be masked, at least 12 feet from one another, and speaking through megaphones with one another. In accordance with public health mandates and guidance, participation will be limited to 20 individuals who sign up to participate ahead of time.

Sign up here: https://belmont.bme.umich.edu/ask-your-questions-to-ponder/

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One's intelligence might be artificially enhanced by the blog: https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Tue, 25 Aug 2020 11:09:51 -0400 2020-09-29T19:00:00-04:00 2020-09-29T20:30:00-04:00 Lurie Biomedical Engineering The Bioethics Discussion Group Lecture / Discussion Artificial Intelligence
Saltiel Life Sciences Symposium 2020 (September 30, 2020 9:00am) https://events.umich.edu/event/72207 72207-17957294@events.umich.edu Event Begins: Wednesday, September 30, 2020 9:00am
Location: Off Campus Location
Organized By: Life Sciences Institute (LSI)

The 2020 Saltiel Life Sciences Symposium will explore innovative and creative research already taking place using unique model systems, and consider all we have yet to learn from the innumerable unexplored model systems — many of which are disappearing at alarming rates as a result of global climate change.

Schedule: Tuesday, September 29

2:00 p.m. | Welcome

Talk Session 1: Human Adaptation and Evolution
2:10 p.m. | Mary Sue and Kenneth Coleman Life Sciences Lecture — Genomic evolution and adaptation in Africa: Implications for health and disease
Sarah A. Tishkoff, Ph.D.
David and Lyn Silfen University Professor, Departments of Genetics and Biology; Director, Center for Global Genomics & Health Equity, Department of Genetics, Perelman School of Medicine, University of Pennsylvania

Talk Session 2: Social Biomimicry
3:10 p.m. | Towards living robots: Using biology to make better machines (full lecture)
Barry A. Trimmer, Ph.D.
Henry Bromfield Pearson Professor of Natural Sciences; Director, Neuromechanics and Biomimetic Devices Laboratory, Tufts University

4:05 p.m. | How the physics of slithering can teach multilegged robots to walk (short talk)
Shai Revzen, Ph.D.
Assistant Professor, Electrical Engineering and Computer Science, University of Michigan

4:25 p.m. | What wasps can teach us about the evolution of animal minds (full lecture)
Elizabeth Tibbetts, Ph.D.
Professor, Associate Chair for Research Facilities, Ecology and Evolutionary Biology, University of Michigan

5:20 p.m. | Day 1 Closing Remarks


Schedule: Wednesday, September 30

9:00 a.m. | Welcome

Talk Session 3: Biological Control of Disease Vectors
9:05 a.m. | Breaking up Anopheles-Plasmodium interactions for malaria control (full lecture)
Flaminia Catteruccia, Ph.D.
Professor, Immunology and Infectious Disease, Harvard University

10:00 a.m. | Cryopreservation of multicellular animals: Lessons from extreme insects (short talk)
Nicholas Teets, Ph.D.
Assistant Professor, Department of Entomology, University of Kentucky

10:20 a.m. | Break

10:35 a.m. | Transgenic fungi for mosquito control (full lecture)
Raymond St. Leger, Ph.D.
Professor, Entomology, University of Maryland

11:30 a.m. | Recombination versus mutation as the fuel for rapid evolution across the fungal tree of life (short talk)
Timothy James, Ph.D.
Associate Professor, Lewis E. Wehmeyer and Elaine Prince Wehmeyer Professor in the Taxonomy of Fungi, Ecology and Evolutionary Biology, University of Michigan

11:50 a.m. | Building a moving wall: Maintaining cell wall polarity during tip growth (short talk)
Cora MacAlister, Ph.D.
Assistant Professor, Department of Molecular, Cellular, and Developmental Biology, University of Michigan

12:10 p.m. | Closing remarks

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Conference / Symposium Wed, 09 Sep 2020 16:23:00 -0400 2020-09-30T09:00:00-04:00 2020-09-30T12:15:00-04:00 Off Campus Location Life Sciences Institute (LSI) Conference / Symposium Saltiel Life Sciences Symposium: Biodiversity in Biological Research
DCMB / CCMB Weekly Virtual Seminar - Xiaotian Zhang, Ph.D. (September 30, 2020 4:00pm) https://events.umich.edu/event/77549 77549-19883820@events.umich.edu Event Begins: Wednesday, September 30, 2020 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract: The human genome is organized into small compartments to allow for the proper gene expression regulation in the physiological process. With the advance of next-generation sequencing and imaging technologies, we can now investigate how the genome is folded into 3D space and how the 3D genomic organization regulates gene expression in development and disease. Currently, most of the studies are focusing on CTCF and cohesion complex which partner together to facilitate the formation of topological associated domains (TAD). The presenter will mainly discuss his recently published work on the DNA methylation -3D genomics cross-talk. Unpublished work on the 3D genomics in AML will be discussed as well.

Short bio: Xiaotian Zhang obtained his Ph.D. at Baylor College of Medicine with Dr. Margaret Goodell on the role of DNA methylation synergy in leukemia development. He was previously the Van Andel special postdoc fellow in Gerd Pfeifer lab working on the 3D genomics in normal hematopoietic stem cell and leukemia. He is now a Research track faculty (Research Investigator) in Pathology Department under Tomek Cierpicki working on the HOXA regulation in leukemia development. Xiaotian's research focuses on the epigenetic regulation of key pathogenic genes in leukemia, particularly on high order chromatin structure in disease. He published on Nature Genetics, Molecular Cell and Blood as the first author and corresponding authors.

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Lecture / Discussion Tue, 22 Sep 2020 09:31:31 -0400 2020-09-30T16:00:00-04:00 2020-09-30T17:00:00-04:00 Off Campus Location DCMB Seminar Series Lecture / Discussion Xiaotian Zhang, Ph.D., Research Investigator in the Department of Pathology at the University of Michigan
BME Seminar Series: Gautam Parthasarathy (October 1, 2020 4:00pm) https://events.umich.edu/event/75905 75905-19623823@events.umich.edu Event Begins: Thursday, October 1, 2020 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Join us for our virtual seminar series on Thursdays from 4-5pm!
These events will take place on BlueJeans at this link: https://bluejeans.com/628109990

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Workshop / Seminar Thu, 20 Aug 2020 13:56:48 -0400 2020-10-01T16:00:00-04:00 2020-10-01T17:00:00-04:00 Off Campus Location Biomedical Engineering Workshop / Seminar BME
RNA Seminar featuring: Chase Weidmann, Washington University School of Medicine in St. Louis (October 5, 2020 4:00pm) https://events.umich.edu/event/76147 76147-19665691@events.umich.edu Event Begins: Monday, October 5, 2020 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

ZOOM REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_y9HTFl5RSOSJTJ5qtlhVcw

Keywords: mRNA regulation, noncoding RNA, RNA Structure, RNP granules

Abstract:
Chase Weidmann, Ph.D. has contributed broadly to the field of RNA Biology during his career, studying mechanisms of codon bias during translation, post-transcriptional regulation of mRNAs by RNA-binding proteins, the folding of long non-coding RNAs, and how RNA-protein interaction networks contribute to the function and assembly of functional RNP particles. Chase developed a chemical probing strategy and next-gen sequencing technology, called RNP-MaP, that maps the location of and cooperation between multi-protein networks on RNAs in live cells. Going forward, Chase is interested in understanding how alterations in RNA-binding protein profiles, a cell’s “RBPome”, confer deleterious activities onto noncoding RNAs in human disease, especially in cancer. To further empower this work and his future research program, Chase is now generating and integrating protein mass spectrometry data into his RBPome projects.

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Lecture / Discussion Wed, 16 Sep 2020 09:01:52 -0400 2020-10-05T16:00:00-04:00 2020-10-05T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion photo
MDP Project Preview Night (October 6, 2020 5:00pm) https://events.umich.edu/event/78172 78172-19989036@events.umich.edu Event Begins: Tuesday, October 6, 2020 5:00pm
Location: Off Campus Location
Organized By: Multidisciplinary Design Program

Join us for a virtual project recruitment event, using the Career Fair Plus software.

- Talk to corporate sponsors and faculty PI’s about their projects
- Register ahead of time for interview slots similar to the engineering career fair
- Upload your resume and be prepared to ask questions
- Read the project descriptions on the MDP website before attending

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Reception / Open House Mon, 05 Oct 2020 12:18:57 -0400 2020-10-06T17:00:00-04:00 2020-10-06T21:00:00-04:00 Off Campus Location Multidisciplinary Design Program Reception / Open House A Sponsor Mentor from the Human Rights First - Multidisciplinary Design Program project speaks with a prospective applicant at the Project Preview Night event in 2019.
MDP Project Fair (October 7, 2020 12:00pm) https://events.umich.edu/event/78176 78176-19989039@events.umich.edu Event Begins: Wednesday, October 7, 2020 12:00pm
Location: Off Campus Location
Organized By: Multidisciplinary Design Program

Join us for a virtual project recruitment event, using the Career Fair Plus software.

- Talk to corporate sponsors and faculty PI’s about their projects
- Register ahead of time for interview slots similar to the engineering career fair
- Upload your resume and be prepared to ask questions
- Read the project descriptions on the MDP website before attending

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Reception / Open House Mon, 05 Oct 2020 12:18:54 -0400 2020-10-07T12:00:00-04:00 2020-10-07T16:00:00-04:00 Off Campus Location Multidisciplinary Design Program Reception / Open House A Sponsor Mentor and a Faculty Mentor from the Northrop Grumman Solar Truss - Multidisciplinary Design Program project speak with a prospective applicant at the Project Preview Night event in 2019.
A Virtual Event: Per- and polyfluoroalkyl substances (PFAS): Exposure, Toxicity, and Policy (October 7, 2020 1:00pm) https://events.umich.edu/event/77430 77430-19854020@events.umich.edu Event Begins: Wednesday, October 7, 2020 1:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

This M-LEEaD Virtual Symposium will focus on issues related to exposure, toxicity, and policy in the unfolding PFAS contamination across Michigan and globally. Speakers will each focus on one of these topics related to their expertise.

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Livestream / Virtual Fri, 18 Sep 2020 12:36:19 -0400 2020-10-07T13:00:00-04:00 2020-10-07T15:00:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Livestream / Virtual 10.7.20 Poster
EER Seminar Series (Engineering Education Research) (October 7, 2020 3:30pm) https://events.umich.edu/event/77660 77660-19899719@events.umich.edu Event Begins: Wednesday, October 7, 2020 3:30pm
Location: Off Campus Location
Organized By: Engineering Education Research

Advancing diversity, inclusion, and equity has been a persistent challenge in engineering. Over the last 40 years, hundreds of papers and more than 25 national reports have been published focusing on broadening participation in STEM. Simultaneously, people throughout the U.S. have been working endlessly to solve this problem. Yet, we have seen only incremental progress, suggesting that there is a need to take a step back and re-examine what has been done, in terms of both research and practice. To support this effort, Dr. Lee’s research focuses on critically evaluating the research-to-practice cycle as it relates to broadening participation. In this seminar, he will discuss an ongoing project focused on the participation of Black Americans in engineering and computer science. The goals of this project are to advance our understanding of the disconnect between research and practice, to identify barriers to progress, and to set a national agenda for broadening the participation of Black Americans in engineering and computer science.

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Lecture / Discussion Thu, 24 Sep 2020 09:41:43 -0400 2020-10-07T15:30:00-04:00 2020-10-07T16:30:00-04:00 Off Campus Location Engineering Education Research Lecture / Discussion Dr. Walter Lee