Happening @ Michigan https://events.umich.edu/list/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (February 26, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656628@events.umich.edu Event Begins: Monday, February 26, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-02-26T14:00:00-05:00 2018-02-26T16:00:00-05:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (February 27, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656539@events.umich.edu Event Begins: Tuesday, February 27, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-02-27T14:00:00-05:00 2018-02-27T16:00:00-05:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
BME - Neural Engineering Seminar (February 27, 2018 3:00pm) https://events.umich.edu/event/50292 50292-11701599@events.umich.edu Event Begins: Tuesday, February 27, 2018 3:00pm
Location: North Campus Research Complex Building 10
Organized By: Biomedical Engineering

Marco Capogrosso, PhD (3:00-4:00 pm): A computational framework for the design of spinal neuroprostheses

Severe Spinal Cord Injury (SCI) alters the communication between supra-spinal centers and the sensorimotor networks coordinating limb movements, leading to motor paralysis. Epidural electrical stimulation of lumbar segments has shown the ability to enable descending motor control of the lower limbs in rodents and humans with severe spinal cord injury. Using a combination of computational models and in-vivo experiments, I’ve found that EES facilitates motor control through the recruitment of muscle spindle feedback circuits. I’ve then used these models to design stimulation protocols targeting these circuits that allowed selective modulation of synergistic muscle groups, both in rodents and primates. This framework supported the design of brain controlled stimulation strategies that restored voluntary locomotion in primates with incomplete spinal cord injury. I am now expanding these models to design new technologies for the restoration of functional arm movements in people with cervical spinal cord injury.

Elvira Pirondini, PhD (4:00-5:00 pm): Robust imaging biomarkers for therapy personalization in neural disorders

Personalized neuro-rehabilitation approaches, such as robot-assisted therapies, have been suggested as a pivotal step to improve the clinical outcome in neural disorders. Indeed, in the past years, robotic systems have become increasingly popular for the use in both upper and lower limb rehabilitation. Nevertheless, clinical studies have so far not been able to confirm the superior efficacy of robotic therapy over conventional methods. The possibility to autonomously and continuously adapt the rehabilitation protocol to the patient’s status based on meaningful measures could improve the clinical relevance of such solutions. However, the identification of such informative and robust biomarkers has remained rather elusive. Here I will briefly discuss how neurophysiological relevant kinematic parameters capable of tracking changes in motor improvement could be identified and used for the personalization of the therapy in real-time. However, while kinematic measurements provide precise behavioral scores, they are unfit to describe the complex neural reorganization processes in neuro-motor disorders. I will therefore present advanced imaging tools to analyze brain activity able to provide novel and rich biomarkers to delineate responses to treatment. These methods will allow improving our understanding of the recovery mechanisms and the design of innovative personalized rehabilitative strategies.

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Lecture / Discussion Tue, 20 Feb 2018 16:14:06 -0500 2018-02-27T15:00:00-05:00 2018-02-27T17:00:00-05:00 North Campus Research Complex Building 10 Biomedical Engineering Lecture / Discussion Event
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (February 28, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656583@events.umich.edu Event Begins: Wednesday, February 28, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-02-28T14:00:00-05:00 2018-02-28T16:00:00-05:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Invensity Workshop (March 6, 2018 6:00pm) https://events.umich.edu/event/50440 50440-11754080@events.umich.edu Event Begins: Tuesday, March 6, 2018 6:00pm
Location: Herbert H. Dow Building
Organized By: Society of Women Engineers

Invensity INC is a German innovation technology consultancy company with it’s first international branch just in Downtown Detroit. With our talent/consultants, who come from engineering backgrounds, we are able to solve clients’ technological challenges through providing a wide range of competences. We always keep up-to-date through a continuous exchange of knowledge, professional development opportunities and close cooperation with our clients.

Majors: Any Engineering Major
Years: Undergraduate, Masters, PhD

Food will be provided
Contact: Society of Women Engineers (swe.cis-ind.PD@umich.edu)

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Careers / Jobs Sun, 25 Feb 2018 01:46:18 -0500 2018-03-06T18:00:00-05:00 2018-03-06T20:00:00-05:00 Herbert H. Dow Building Society of Women Engineers Careers / Jobs Herbert H. Dow Building
Bioethics Discussion: LGBTQ Health (March 6, 2018 7:00pm) https://events.umich.edu/event/43726 43726-9832714@events.umich.edu Event Begins: Tuesday, March 6, 2018 7:00pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: The Bioethics Discussion Group

A roundtable discussion including inclusion and finding ourselves.

A few essays to consider:
"Growing pains: problems with puberty suppression in treating gender dysphoria"
"The duty to warn and clinical ethics: legal and ethical aspect of confidentiality and HIV/AIDS"
"Obergefell v. Hodges Decision"

For more information and/or to receive a copy of the essays, please contact Barry Belmont (belmont@umich.edu).

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Lecture / Discussion Tue, 21 Nov 2017 10:25:36 -0500 2018-03-06T19:00:00-05:00 2018-03-06T20:30:00-05:00 Lurie Biomedical Engineering (formerly ATL) The Bioethics Discussion Group Lecture / Discussion LGBTQ health
BME 500 Seminar: Grace Zhang, Ph.D. (March 8, 2018 4:00pm) https://events.umich.edu/event/48975 48975-11342260@events.umich.edu Event Begins: Thursday, March 8, 2018 4:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Details to be determined.

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Lecture / Discussion Fri, 19 Jan 2018 12:02:17 -0500 2018-03-08T16:00:00-05:00 2018-03-08T17:00:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Lecture / Discussion event
Microbiome & Population Health: challenges & opportunities (March 9, 2018 9:00am) https://events.umich.edu/event/49192 49192-11386629@events.umich.edu Event Begins: Friday, March 9, 2018 9:00am
Location: Public Health I (Vaughan Building)
Organized By: MAC-EPID

Please register for MAC-EPID's winter symposium! This will be a partial-day symposium which includes lunch.

Guest speakers:
Melinda Pettigrew (Yale University)
Andrew Moeller (UC Berkeley)
Ashley Shade (Michigan State)

* * * * *
For more information and registration for this FREE event:
www.MAC-EPID.org
Anna Cronenwett, weaverd@umich.edu

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Conference / Symposium Tue, 23 Jan 2018 16:00:19 -0500 2018-03-09T09:00:00-05:00 2018-03-09T15:00:00-05:00 Public Health I (Vaughan Building) MAC-EPID Conference / Symposium Flyer
Clinical Trials (March 12, 2018 12:30pm) https://events.umich.edu/event/50800 50800-11870497@events.umich.edu Event Begins: Monday, March 12, 2018 12:30pm
Location: North Campus Research Complex Building 10
Organized By: The Bioethics Discussion Group

A lunchtime discussion with Professors Cynthia Chestek and James Weiland, on the ethical implications of experimental medical trials, on the responsibilities of the caregivers to their patients (current and future), and how we actually know what we're doing is both true and useful. Sponsored by the Biointerfaces Research Group (BIRG).

Come for free food, profound thoughts, open discussion.

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Lecture / Discussion Wed, 07 Mar 2018 11:48:58 -0500 2018-03-12T12:30:00-04:00 2018-03-12T13:30:00-04:00 North Campus Research Complex Building 10 The Bioethics Discussion Group Lecture / Discussion Clinical trials
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (March 12, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656630@events.umich.edu Event Begins: Monday, March 12, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-03-12T14:00:00-04:00 2018-03-12T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (March 13, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656541@events.umich.edu Event Begins: Tuesday, March 13, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-03-13T14:00:00-04:00 2018-03-13T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Health Lies in Action (March 14, 2018 1:30pm) https://events.umich.edu/event/49029 49029-11364398@events.umich.edu Event Begins: Wednesday, March 14, 2018 1:30pm
Location: Lurie Biomedical Engineering
Organized By: Biomedical Engineering

A lecture on the next generation of physiological monitoring as embodied by wearable, therables, and the quantified self.

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Lecture / Discussion Sun, 21 Jan 2018 15:03:24 -0500 2018-03-14T13:30:00-04:00 2018-03-14T15:30:00-04:00 Lurie Biomedical Engineering Biomedical Engineering Lecture / Discussion Health lies in action
Quantifying the Self: "Health lies in action" (March 14, 2018 1:30pm) https://events.umich.edu/event/49189 49189-11386621@events.umich.edu Event Begins: Wednesday, March 14, 2018 1:30pm
Location: Lurie Biomedical Engineering
Organized By: Biomedical Engineering

The Bioethics Discussion Group and the Transforming Engineering Education col-Laboratory present a lecture on the next generation of physiological monitoring wherein wearables and therables meet physiology when and where it happens.

For more information please contact belmont@umich.edu.

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Lecture / Discussion Tue, 23 Jan 2018 15:40:43 -0500 2018-03-14T13:30:00-04:00 2018-03-14T15:30:00-04:00 Lurie Biomedical Engineering Biomedical Engineering Lecture / Discussion quantifying the self
Quantifying the Self: Three Lectures on Human Instruments (March 14, 2018 1:30pm) https://events.umich.edu/event/49030 49030-11364403@events.umich.edu Event Begins: Wednesday, March 14, 2018 1:30pm
Location: Lurie Biomedical Engineering
Organized By: The Bioethics Discussion Group

A series of three lectures on the methods and consequences of measuring our biomedical conditions.

Topics include:
Jan 24 – "For the heart, life is simple" – Cardiovascular dynamics as measured by pressures, volumes, and flows

Feb 7 – "I sing the body electric" – Electrophysiology of the brain, the heart, the muscles, the eyes, and the gut

Mar 14 – "Health lies in action" – Next generation physiological monitoring: wearables, therables, and capturing physiology when and where it happens.

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Lecture / Discussion Sun, 21 Jan 2018 15:16:20 -0500 2018-03-14T13:30:00-04:00 2018-03-14T15:30:00-04:00 Lurie Biomedical Engineering The Bioethics Discussion Group Lecture / Discussion Quantifying the Self
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (March 14, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656585@events.umich.edu Event Begins: Wednesday, March 14, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-03-14T14:00:00-04:00 2018-03-14T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
BME 500 Seminar: Keith Neeves, Ph.D. (March 15, 2018 4:00pm) https://events.umich.edu/event/48976 48976-11342261@events.umich.edu Event Begins: Thursday, March 15, 2018 4:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Details to be determined.

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Lecture / Discussion Fri, 19 Jan 2018 12:04:34 -0500 2018-03-15T16:00:00-04:00 2018-03-15T17:00:00-04:00 Electrical Engineering and Computer Science Building Biomedical Engineering Lecture / Discussion event
A Philosophical Movie Night: Synecdoche, New York (March 15, 2018 5:00pm) https://events.umich.edu/event/50904 50904-11899299@events.umich.edu Event Begins: Thursday, March 15, 2018 5:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: The Bioethics Discussion Group

A film on the human condition. Who are we as we change over time? How revealing/intimate must art be to express deeper/more existential truths? Will there be food?

At least to the last question, yes. Please come and enjoy.

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Film Screening Fri, 09 Mar 2018 19:03:41 -0500 2018-03-15T17:00:00-04:00 2018-03-15T20:00:00-04:00 Electrical Engineering and Computer Science Building The Bioethics Discussion Group Film Screening Synecdoche, New York
Movie Night on North (March 15, 2018 5:00pm) https://events.umich.edu/event/50903 50903-11899298@events.umich.edu Event Begins: Thursday, March 15, 2018 5:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

The Engineering Student Government has asked our very own Barry Belmont to host a discussion for its "Movie Night on North" series. The film he has chosen is Synecdoche, New York, a postmodern-meta-take on our human condition in general and aspects of our biomedical condition more specifically.

There will be food and merriment. Stop by if you're free.

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Film Screening Fri, 09 Mar 2018 18:58:36 -0500 2018-03-15T17:00:00-04:00 2018-03-15T20:00:00-04:00 Electrical Engineering and Computer Science Building Biomedical Engineering Film Screening Synecdoche
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (March 19, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656631@events.umich.edu Event Begins: Monday, March 19, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-03-19T14:00:00-04:00 2018-03-19T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (March 20, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656542@events.umich.edu Event Begins: Tuesday, March 20, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-03-20T14:00:00-04:00 2018-03-20T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Bioethics Discussion: Vaccination (March 20, 2018 7:00pm) https://events.umich.edu/event/43727 43727-9832715@events.umich.edu Event Begins: Tuesday, March 20, 2018 7:00pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: The Bioethics Discussion Group

A roundtable discussion on public health and individual choice.

A few essays to consider:
"Ileal-lymphoid-nodular hyperplasia non-specific colitis, and pervasive developmental disorder in children"
"The moral case for the routine vaccination of children in develop and developing countries"
"Ethics and infectious disease"

For more information and/or to receive copies of the essay, please contact Barry Belmont (belmont@umich.edu).

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Lecture / Discussion Tue, 21 Nov 2017 10:26:12 -0500 2018-03-20T19:00:00-04:00 2018-03-20T20:30:00-04:00 Lurie Biomedical Engineering (formerly ATL) The Bioethics Discussion Group Lecture / Discussion Vaccination
ONSF National Scholarship Workshop 1 (March 21, 2018 12:00pm) https://events.umich.edu/event/51051 51051-11950556@events.umich.edu Event Begins: Wednesday, March 21, 2018 12:00pm
Location: Chrysler Center
Organized By: Tau Beta Pi

Applying for National Scholarships I: Exploring and Preparing

Dr. Henry Dyson, Director of the Office of National Scholarships and Fellowships (ONSF) at UM will give the first of a series of two presentations on applying for national scholarships. Anyone interested in applying for competitive national scholarships (e.g. Rhodes, Churchill, Goldwater, Knight-Hennessy, etc.) is highly encouraged to attend. Lunch will be provided.

Please sign up with this Google form in addition to signing up on the TBP website: https://docs.google.com/forms/d/1eW_fkInsU_iKV-eZG4ENfAY0kuYNeLxFpxl5zAF70s8/edit?ts=5aa18bf0

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Careers / Jobs Wed, 14 Mar 2018 10:02:28 -0400 2018-03-21T12:00:00-04:00 2018-03-21T13:00:00-04:00 Chrysler Center Tau Beta Pi Careers / Jobs Chrysler Center
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (March 21, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656586@events.umich.edu Event Begins: Wednesday, March 21, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-03-21T14:00:00-04:00 2018-03-21T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Sling Health -- Innovation Demo Day (March 21, 2018 6:30pm) https://events.umich.edu/event/51045 51045-11944872@events.umich.edu Event Begins: Wednesday, March 21, 2018 6:30pm
Location: Taubman Biomedical Science Research Building
Organized By: Sling Health

Demo Day is our capstone event where Sling Health teams from across campus present entrepreneurial solutions that they have developed for a variety of medical fields. Over $3000 in prizes will be awarded, and non Sling Health teams are encouraged to apply to compete!

At the end of the night, there will be a crowd favorite prize awarded in addition to prizes awarded by an expert panel of judges. Please feel free to bring your friends for a night of fun, food, and learning. In addition, there will be 3 $50 Amazon gift cards randomly awarded to those who are present and have RSVP'd. RSVP at michigan.slinghealth.org

More info on our program: Sling Health is a bioengineering design and entrepreneurship incubator that helps facilitate student teams address medical issues to improve healthcare. It is completely student-run, bringing together engineers, medical students, and law/business students. Selected students work in small teams comprised of law, engineering, medical, and business students. This national organization has created 15 startups and raised over 4 million dollars in outside investments and awards since our inception in 2013.

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Conference / Symposium Tue, 13 Mar 2018 18:59:40 -0400 2018-03-21T18:30:00-04:00 2018-03-21T21:00:00-04:00 Taubman Biomedical Science Research Building Sling Health Conference / Symposium Innovation Demo Day Flyer
The 2018 MICDE Annual Symposium (March 22, 2018 8:00am) https://events.umich.edu/event/48890 48890-11320067@events.umich.edu Event Begins: Thursday, March 22, 2018 8:00am
Location: Rackham Graduate School (Horace H.)
Organized By: Michigan Institute for Computational Discovery and Engineering

The symposium will highlight how computational science is advancing research from the molecular to the atmospheric scale.
We welcome back Cleve Moler, original author of Matlab ®, and co-founder of MathWorks, as a keynote speaker.
He will be joined by: Gurudurth Banavar — co-founder and CTO, Viome; Cyhthia Chestek — Biomedical Engineering & EECS, U-M; Alison Marsden — Pediatrics and Bioengineering, Stanford University; Raju Namburu — Chief Scientist, Army Research Lab; Stephen Smith — Ecology and Evolutionary Biology, U-M; Beth Wingate — Professor of Mathematics, University of Exeter.

As always, the symposium will also feature a poster competition highlighting notable computational work from U-M postdocs and students. The posters have proved highly popular in previous years, and we look forward to this year’s submissions.

Please RSVP at micde.umich.edu/symposium18

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Conference / Symposium Tue, 13 Mar 2018 10:28:06 -0400 2018-03-22T08:00:00-04:00 2018-03-22T17:00:00-04:00 Rackham Graduate School (Horace H.) Michigan Institute for Computational Discovery and Engineering Conference / Symposium Symposium Image
BME 500 Seminar: Angela Pannier, Ph.D. (March 22, 2018 4:00pm) https://events.umich.edu/event/48977 48977-11342262@events.umich.edu Event Begins: Thursday, March 22, 2018 4:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Angela K. Pannier, Ph.D.
Associate Professor, Biological Systems Engineering Department
University of Nebraska

“Priming Nonviral Gene Delivery for Stem Cell and Vaccination Applications”

Abstract:
Gene delivery is the delivery of exogenous genetic material to cells with the goal of altering molecular physiology to produce a cellular or systemic phenotype change. Unlike many conventional drugs, free nucleic acids are not readily internalized by eukaryotic cells due to size and charge, but many methods of their delivery to cells are the subject of intense research, including viral and non-viral methods. Non-viral gene delivery methods are much less efficient than viral methods, but flexibility in genetic cargo, ease of transfection protocols, and lack of safety issues make them advantageous alternatives. Strategies to engineer more effective non-viral gene delivery materials and methods are highly dependent on variable parameters such as cell type and application, and have focused on engineering increasingly more complex lipid and polymer vectors, but the rational design of new technologies is limited by our current knowledge of several key cellular barriers. To expand our knowledge of the “biology of transfection” our group has made efforts to understand the process of gene delivery, using diverse tools include modeling, gene expression analysis, high throughput screening, cell priming, and the development of new material systems, for stem cell and vaccination applications.

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Lecture / Discussion Tue, 20 Mar 2018 15:09:28 -0400 2018-03-22T16:00:00-04:00 2018-03-22T17:00:00-04:00 Electrical Engineering and Computer Science Building Biomedical Engineering Lecture / Discussion event
Gupta Family Hackathon for Health Communication (March 24, 2018 8:00am) https://events.umich.edu/event/50274 50274-11698730@events.umich.edu Event Begins: Saturday, March 24, 2018 8:00am
Location: Taubman Biomedical Science Research Building
Organized By: Institute for Healthcare Policy and Innovation

As CNN’s medical correspondent, Sanjay Gupta, M.D. has covered many disasters, medical discoveries, epidemics and catastrophes – enough to see the crucial role of effective and timely communication of health information.

On March 23-25, he and his wife Rebecca will team up with U-M to host an innovation event aimed at generating new ideas and tools to improve health communication.

The marathon weekend event, called the Gupta Family Hackathon, will include more than 200 students and professionals from the worlds of health, digital technology, design, communication and information science. Teams will form, work over the weekend, and present their prototypes for judging, competing for a chance to develop their ideas further with the help of U-M mentors.

The application to participate opens this month, and applicants will be selected on a rolling basis until March 1. There is no cost to participate, and food and team working space will be provided.

Organized by the U-M Institute for Healthcare Policy and Innovation, the event is co-supported by a gift from the Guptas and by Michigan Medicine, U-M’s academic medical center.

Learn more and apply at https://guptahacks.org/.

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Conference / Symposium Tue, 20 Feb 2018 09:46:01 -0500 2018-03-24T08:00:00-04:00 2018-03-24T23:00:00-04:00 Taubman Biomedical Science Research Building Institute for Healthcare Policy and Innovation Conference / Symposium Gupta Family Hackathon banner
Gupta Family Hackathon for Health Communication (March 25, 2018 12:00am) https://events.umich.edu/event/50274 50274-11698731@events.umich.edu Event Begins: Sunday, March 25, 2018 12:00am
Location: Taubman Biomedical Science Research Building
Organized By: Institute for Healthcare Policy and Innovation

As CNN’s medical correspondent, Sanjay Gupta, M.D. has covered many disasters, medical discoveries, epidemics and catastrophes – enough to see the crucial role of effective and timely communication of health information.

On March 23-25, he and his wife Rebecca will team up with U-M to host an innovation event aimed at generating new ideas and tools to improve health communication.

The marathon weekend event, called the Gupta Family Hackathon, will include more than 200 students and professionals from the worlds of health, digital technology, design, communication and information science. Teams will form, work over the weekend, and present their prototypes for judging, competing for a chance to develop their ideas further with the help of U-M mentors.

The application to participate opens this month, and applicants will be selected on a rolling basis until March 1. There is no cost to participate, and food and team working space will be provided.

Organized by the U-M Institute for Healthcare Policy and Innovation, the event is co-supported by a gift from the Guptas and by Michigan Medicine, U-M’s academic medical center.

Learn more and apply at https://guptahacks.org/.

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Conference / Symposium Tue, 20 Feb 2018 09:46:01 -0500 2018-03-25T00:00:00-04:00 2018-03-25T16:00:00-04:00 Taubman Biomedical Science Research Building Institute for Healthcare Policy and Innovation Conference / Symposium Gupta Family Hackathon banner
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (March 26, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656632@events.umich.edu Event Begins: Monday, March 26, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-03-26T14:00:00-04:00 2018-03-26T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (March 27, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656543@events.umich.edu Event Begins: Tuesday, March 27, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-03-27T14:00:00-04:00 2018-03-27T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (March 28, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656587@events.umich.edu Event Begins: Wednesday, March 28, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-03-28T14:00:00-04:00 2018-03-28T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
BME 500 Seminar: Fernando Boada, Ph.D. (March 29, 2018 4:00pm) https://events.umich.edu/event/48978 48978-11342263@events.umich.edu Event Begins: Thursday, March 29, 2018 4:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Fernando E. Boada, Ph.D.
Professor of Radiology, Psychiatry and Neurosurgery
Director, Center for Advanced Imaging Innovation and Research
Co-Director, Center for Biomedical Imaging
New York University


“MR/PET Synergies: Correcting Motion During Dynamic MR/PET Scans Through Self
Refocused Navigators and Coil Fingerprints”

Abstract:
MR/PET scanners allow simultaneous acquisition of MR and PET scans during clinical examinations. This feature has great potential to improve our ability to capitalize on PET’s unique capabilities to probe important metabolic processes in vivo. Examples include: improving image quality for low specific activity tracers through the use of joint MR/PET reconstruction, reduction of radiation exposure (90%) for standard-of-care Fluorodeoxyglucose (FDG) scans, improvement of tracer kinetic analysis and motion correction of dynamic PET scans. Motion correction of dynamic PET scans, in particular, is an unmet challenge as the use of external gating signals for retrospective motion correction has proven unreliable for a variety of different reasons. In this presentation, we demonstrate an approach for motion correction of MR/PET scans based on the use of short, self-refocused, multidimensional navigator modules. These modules allow continuous (every TR) tracking of abdominal motion through monitoring of the time course of the “generalized projections” spatially encoded by the navigator modules. We demonstrate, using in-vivo as well as motion phantom data, that these modules are compatible with both 3D and 2D MRI- sequences and that their use allows the removal of large (60%) quantitative biases in PET scans due to multi-dimensional (i.e., cardiac and respiratory) motion blur.

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Lecture / Discussion Fri, 23 Mar 2018 11:46:42 -0400 2018-03-29T16:00:00-04:00 2018-03-29T17:00:00-04:00 Electrical Engineering and Computer Science Building Biomedical Engineering Lecture / Discussion event
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (April 2, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656633@events.umich.edu Event Begins: Monday, April 2, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-04-02T14:00:00-04:00 2018-04-02T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
RNA Innovation Seminar Series | Theme: "Epigenetics" (April 2, 2018 3:00pm) https://events.umich.edu/event/49696 49696-11498714@events.umich.edu Event Begins: Monday, April 2, 2018 3:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Sue Hammoud, Ph.D.
Assistant Professor of Human Genetics
Assistant Professor of Urology

and

Laura Buttitta, Ph.D.
Assistant Professor of Molecular, Cellular and Developmental Biology

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Lecture / Discussion Wed, 07 Feb 2018 10:18:30 -0500 2018-04-02T15:00:00-04:00 2018-04-02T16:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion seminar flyer
2018 Cellular Biotechnology Training Program Symposium (April 3, 2018 1:15pm) https://events.umich.edu/event/50612 50612-11816525@events.umich.edu Event Begins: Tuesday, April 3, 2018 1:15pm
Location: Palmer Commons
Organized By: Biomedical Engineering

1:15 Symposium Opening
1:20 Student Talk: Steven Romaneli, MacDougald Lab
1:40 Student Talk: Cameron Louttit, Moon Lab
2:00 Faculty Talk: Dr. Jason Spence
2:45 Keynote Talk
4:00 Poster Session and Refreshments

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Presentation Fri, 02 Mar 2018 13:54:50 -0500 2018-04-03T13:15:00-04:00 2018-04-03T16:00:00-04:00 Palmer Commons Biomedical Engineering Presentation Keynote Speaker: Dr. Lydia Villa-Komaroff Scientist, Business Executive, and Diversity Advocate
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (April 3, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656544@events.umich.edu Event Begins: Tuesday, April 3, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-04-03T14:00:00-04:00 2018-04-03T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
University of Southern California - Viterbi School of Engineering Info Session (April 3, 2018 6:00pm) https://events.umich.edu/event/51401 51401-12098136@events.umich.edu Event Begins: Tuesday, April 3, 2018 6:00pm
Location: Herbert H. Dow Building
Organized By: Society of Women Engineers

Students interested in Engineering/CS MS, PhD programs and REU Programs
Majors: ALL ENGINEERING MAJORS
Degrees: Undergraduate, Masters
Citizenship: None
Resumes: No

The University of Southern California is a top-10 ranked (by U.S. News & World Report) graduate engineering program with over 70 PhD and Master's programs in 13 engineering disciplines. There will be presentation covering:

· Grad School Overview – MS vs. PhD
· Overview of USC and the Viterbi School
· MS & PhD Programs
· Summer Undergraduate Research Experience
· Application Process
· Tuition & Fees
· Q&A

Refreshments will be provided. Also, attendees will be eligible to request a $90 application fee waiver.

For questions, contact Ray Fujioka at fujioka@usc.edu

Register at: http://bit.ly/usc-umich

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Careers / Jobs Thu, 29 Mar 2018 17:33:47 -0400 2018-04-03T18:00:00-04:00 2018-04-03T19:30:00-04:00 Herbert H. Dow Building Society of Women Engineers Careers / Jobs Herbert H. Dow Building
Bioethics Discussion: Regulation (April 3, 2018 7:00pm) https://events.umich.edu/event/43728 43728-9832716@events.umich.edu Event Begins: Tuesday, April 3, 2018 7:00pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: The Bioethics Discussion Group

A roundtable discussion about the maze and the pathway.

A few essays to consider:
"Thalidomide retrospective: what did we learn?"
"Improving medical device regulation: the United States and Europe in perspective"
"Ethics, regulation, and comparative effectiveness research"

For more information and/or to receive a copy of the essays, please contact Barry Belmont (belmont@umich.edu) or visit https://belmont.bme.umich.edu/bioethics-discussion-group/discussions/014-regulation/.

Feel free to also swing by the blog: https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Wed, 21 Mar 2018 09:33:28 -0400 2018-04-03T19:00:00-04:00 2018-04-03T20:30:00-04:00 Lurie Biomedical Engineering (formerly ATL) The Bioethics Discussion Group Lecture / Discussion Regulation
ONSF National Scholarship Workshop 2 (April 4, 2018 12:00pm) https://events.umich.edu/event/51054 51054-11950558@events.umich.edu Event Begins: Wednesday, April 4, 2018 12:00pm
Location: Chrysler Center
Organized By: Tau Beta Pi

Applying for National Scholarships II: Essay, Letters, and Interviews

Dr. Henry Dyson, Director of the Office of National Scholarships and Fellowships (ONSF) at UM will give the second of a series of two presentations on applying for national scholarships. Anyone interested in applying for competitive national scholarships (e.g. Rhodes, Churchill, Goldwater, Knight-Hennessy, etc.) is highly encouraged to attend. Lunch will be provided.

Please sign up for this Google form in addition to signing up on the TBP website: (https://docs.google.com/forms/d/e/1FAIpQLScy5O5Faf4wllC6HEtttbgsLz9pZ3BZqQthlZDBPqMc-8f-ew/viewform)

Dr. Dyson will hold office hours for individual meetings from 1-3pm following the presentation. Please sign up on his [calendar](https://calendar.google.com/calendar/selfsched?sstoken=UUFhZHhMSjVfUHlzfGRlZmF1bHR8MDA1NWI0OWY1N2Q1YWNmNDkwZjQ3OGNlNzNjMDBhZDU).

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Careers / Jobs Fri, 16 Mar 2018 09:55:04 -0400 2018-04-04T12:00:00-04:00 2018-04-04T13:00:00-04:00 Chrysler Center Tau Beta Pi Careers / Jobs Chrysler Center
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (April 4, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656588@events.umich.edu Event Begins: Wednesday, April 4, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-04-04T14:00:00-04:00 2018-04-04T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
BME 500 Seminar: Konstantinos Konstantopoulos, Ph.D. (April 5, 2018 4:00pm) https://events.umich.edu/event/48979 48979-11342264@events.umich.edu Event Begins: Thursday, April 5, 2018 4:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Konstantinos Konstantopoulos, Ph.D.
Department of Chemical & Biomolecular Engineering
The Johns Hopkins University


“Think Inside the Channel: Lessons from Cancer Cell Migration in Confinement”

Abstract:
During the process of cancer metastasis, tumor cells separate from a primary tumor, migrate across blood vessel walls into the circulation and disperse throughout the body to colonize distant organs. This seminar will present an interdisciplinary approach, integrating engineering fundamentals with molecular cell biology techniques to understand cancer cell locomotion in engineered microenvironments, which recapitulate the three-dimensional longitudinal channels encountered in vivo. This presentation will focus on how tumor cells sense, adapt and respond to different physical microenvironments. The seminar will also discuss how this knowledge has led to the development of a microchannel assay capable of distinguishing aggressive from non-aggressive cancer cells for diagnosis, prognosis and precision care of cancer patients.

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Lecture / Discussion Thu, 05 Apr 2018 02:00:57 -0400 2018-04-05T16:00:00-04:00 2018-04-05T17:00:00-04:00 Electrical Engineering and Computer Science Building Biomedical Engineering Lecture / Discussion event
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (April 9, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656634@events.umich.edu Event Begins: Monday, April 9, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-04-09T14:00:00-04:00 2018-04-09T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (April 10, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656545@events.umich.edu Event Begins: Tuesday, April 10, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-04-10T14:00:00-04:00 2018-04-10T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (April 11, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656589@events.umich.edu Event Begins: Wednesday, April 11, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-04-11T14:00:00-04:00 2018-04-11T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
BME 500 Seminar: Flemming Forsberg, Ph.D. (April 12, 2018 4:00pm) https://events.umich.edu/event/48984 48984-11342269@events.umich.edu Event Begins: Thursday, April 12, 2018 4:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Flemming Forsberg, Ph.D.
Department of Radiology
Thomas Jefferson University

“Quantitative ultrasound contrast imaging from pre-clinical models to human trials”

Abstract:
The use of gas filled microbubbles (1-10 μm in diameter) as vascular tracers and contrast agents for ultrasound imaging is well established. Such contrast agents are used worldwide to improve the diagnostic capabilities of ultrasound imaging especially when employed in combination with novel nonlinear contrast imaging modes such pulse inversion second harmonic and subharmonic imaging (SHI). Our group produced the first ever human SHI images. We have previously shown that SHI signals can indicate hydrostatic pressures in vitro and has developed a noninvasive pressure measurement technique, known as subharmonic-aided pressure estimation (SHAPE), based on this principle. Noninvasive SHAPE measurements may be a useful alternative to catheter- based measurements of cardiac conditions or portal hypertension. Here, we present results from our pre-clinical and clinical trials on the utility of ultrasound contrast imaging in general as well as quantitative SHI and SHAPE results in particular.

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Lecture / Discussion Fri, 06 Apr 2018 13:40:47 -0400 2018-04-12T16:00:00-04:00 2018-04-12T17:00:00-04:00 Electrical Engineering and Computer Science Building Biomedical Engineering Lecture / Discussion event
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (April 16, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656635@events.umich.edu Event Begins: Monday, April 16, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-04-16T14:00:00-04:00 2018-04-16T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
BME Master's Thesis Defense - Ann Gu (April 17, 2018 10:30am) https://events.umich.edu/event/51953 51953-12321831@events.umich.edu Event Begins: Tuesday, April 17, 2018 10:30am
Location: Lurie Biomedical Engineering
Organized By: Biomedical Engineering

Multi-Label Classification of Motor Tasks using fMRI Data

Within the past decade, predicting brain states by applying classification-based multi-voxel pattern analysis (MVPA) to functional magnetic resonance imaging (fMRI) data has become popular. In traditional classification-based MVPA, each class or label is modeled as having a unique spatial brain activity. Multi-Label classification is an emerging machine learning paradigm that can detect multiple classes, that are not necessarily mutually exclusive, in a single instance.

For this study, we extend a support vector machine (SVM) algorithm, a popular MVPA approach, to a multi-label algorithm that can detect both left and right hand tapping tasks simultaneously. Participants performed four tasks in a blocked experiment design: rest, right hand tapping, left hand tapping, and both hands tapping. We compare two training models with our multi-label data. One considers both hands tapping as a new class. The other considers both hands tapping as a positive instance of right and left hand tapping. Furthermore, we investigate the effects of SVM parameters on our algorithm’s performance. Our results demonstrates the feasibility of using a multi-label paradigm for motor task fMRI data. We discuss the capabilities and limitations of our approach and the potential to generalize to other fMRI task-based applications.

Chair: Scott Peltier

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Other Sun, 15 Apr 2018 21:49:54 -0400 2018-04-17T10:30:00-04:00 2018-04-17T12:00:00-04:00 Lurie Biomedical Engineering Biomedical Engineering Other event
BME Master's Thesis Defense - Catherine Long (April 17, 2018 1:00pm) https://events.umich.edu/event/51952 51952-12321830@events.umich.edu Event Begins: Tuesday, April 17, 2018 1:00pm
Location: Gerstacker Building
Organized By: Biomedical Engineering

Engineering an immune-isolating hydrogel for in vitro cancer cell containment to prevent the reintroduction of cancer cells following ovarian tissue autotransplantation

Abstract:
The sterilizing effects of chemotherapy on childhood cancer patients complicate treatment pathways and propagate far into adulthood, yet fertility preservation options exist only for adults. With a specific focus on prepubertal girls, there is only one option to preserve fertility and ovarian endocrine function after cancer treatment: ovarian tissue cryopreservation prior to treatment followed by autotransplantation when the patient is disease free and is ready to undergo puberty or have children. Unfortunately, ovarian tissue in patients with blood borne cancers, such as leukemia, may carry cancer cells and present risks of cancer cell transfer. In response, we have developed a hydrogel-based immune-isolating capsule that protects an allogeneic encapsulated ovarian tissue from immune cells, allows diffusion of nutrients, and promotes tissue survival and function. In this study, we investigated whether the immune-isolating autograft-compatible capsule can prevent cancer cells present with the encapsulated ovarian tissue from escaping the capsule and invading the host tissues, possibly causing cancer relapse. The tested conditions included two levels of encapsulated cancer cells in designs that varied hydrogel shell thickness, core composition strength, and multi-layered construction. These hydrogels were imaged to monitor cancer cell growth and migration through the capsule, and tests for cell viability were conducted to confirm sufficient diffusivity of each design. Additionally, follicle growth expansion with co-encapsulated cancer cells was measured to demonstrate functionality of the device as a suitable environment for tissue survival. By adding an extra layer to the outside of the original hydrogel, the double shelled design was found to be successful in containing cancer cells for up to 34 days without compromising the influx of nutrients necessary for survival. With finding a hydrogel design that successfully retains cancerous cells and facilitates follicle growth, the prospect of utilizing immune-isolating hydrogels as a fertility preservation option for childhood cancer survivors is increasingly promising.

Chair: Ariella Shikanov

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Other Sun, 15 Apr 2018 21:45:11 -0400 2018-04-17T13:00:00-04:00 2018-04-17T14:00:00-04:00 Gerstacker Building Biomedical Engineering Other event
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (April 17, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656546@events.umich.edu Event Begins: Tuesday, April 17, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-04-17T14:00:00-04:00 2018-04-17T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
BME Master's Thesis Defense - Leora Goldbloomhelzner (April 17, 2018 2:30pm) https://events.umich.edu/event/51951 51951-12321829@events.umich.edu Event Begins: Tuesday, April 17, 2018 2:30pm
Location: Lurie Robert H. Engin. Ctr
Organized By: Biomedical Engineering

Department of Biomedical Engineering Master's Thesis Defense

Leora Goldbloomhelzner

Title: Studying the Interplay between BMPR1a-Mediated Signaling and the Stiffness of the Neural Crest Cell Microenvironment during Chondrogenesis

Extensive research has been conducted to understand the role of the stem cell microenvironment, including growth factors and extracellular matrix composition and stiffness, in mediating chondrogenesis during development of the appendicular skeleton, but much is still unknown about the interplay of these factors during chondrogenic differentiation of neural crest cells (NCC) in the temporomandibular joint (TMJ). Over 30 million US adults suffer from osteoarthritis and for those whose condition is localized in the TMJ, tissue engineering studies and treatment are limited. With a better understanding of the crosstalk between cell microenvironment and BMP signaling, design of cartilage regeneration strategies for injured/diseased craniofacial joints can be improved. To investigate this interaction, we studied the chondrogenesis of NCCs with constitutively active BMPR1a receptors in a novel biosynthetic stem cell niche with tunable stiffness and pre-chondrocyte ECM ligand presentation. To reveal how a controlled variation of the microenvironment affects BMP-mediated chondrogenesis, we encapsulated NCCs in 7kPa and 30kPa PEG hydrogels to determine the effect of microenvironmental stiffness chondrogenesis of NCCs mediated by the BMPR1a receptor.

Chair: Rhima Coleman, Ph.D.

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Other Sun, 15 Apr 2018 21:41:26 -0400 2018-04-17T14:30:00-04:00 2018-04-17T15:30:00-04:00 Lurie Robert H. Engin. Ctr Biomedical Engineering Other event
Bioethics Discussion: Posthumanity (April 17, 2018 7:00pm) https://events.umich.edu/event/43729 43729-9832717@events.umich.edu Event Begins: Tuesday, April 17, 2018 7:00pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: The Bioethics Discussion Group

A roundtable discussion on our end.

A few essays to consider:
"In defense of posthuman dignity"
"Stem cells, biotechnology, and human rights: implications for a posthuman future"
"A cyborg manifesto"

For more information and/or to receive a copy of the essays, please contact Barry Belmont (belmont@umich.edu) or visit https://belmont.bme.umich.edu/bioethics-discussion-group/discussions/015-posthumanity/.

Also, feel free to swing by the blog: https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Wed, 21 Mar 2018 09:34:57 -0400 2018-04-17T19:00:00-04:00 2018-04-17T20:30:00-04:00 Lurie Biomedical Engineering (formerly ATL) The Bioethics Discussion Group Lecture / Discussion Posthumanity
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (April 18, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656590@events.umich.edu Event Begins: Wednesday, April 18, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-04-18T14:00:00-04:00 2018-04-18T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (April 23, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656636@events.umich.edu Event Begins: Monday, April 23, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-04-23T14:00:00-04:00 2018-04-23T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
BME Final Oral Exam: Brandan Walters (April 24, 2018 10:00am) https://events.umich.edu/event/51950 51950-12321828@events.umich.edu Event Begins: Tuesday, April 24, 2018 10:00am
Location: Lurie Robert H. Engin. Ctr
Organized By: Biomedical Engineering

Department of Biomedical Engineering Final Oral Examination

Brandan Walters

Morphometric Analysis to Characterize the Differentiation of Mesenchymal Stem Cells
into Smooth Muscle Cells in Response to Biochemical and Mechanical Stimulation

The morphology and biochemical phenotype of cells are closely linked. This relationship is important in progenitor cell bioengineering, which generates functional, tissue-specific cells from uncommitted precursors. Advances in biofabrication have demonstrated that cell shape can regulate cell behavior and alter phenotype-specific functions. Establishing accessible and rigorous techniques for quantifying cell shape will therefore facilitate assessment of cellular responses to environmental stimuli, and will enable more comprehensive understanding of developmental, pathological, and regenerative processes. For progenitor cells being induced into specific lineages, this ability is valuable for validating the degree of differentiation and may lead to novel strategies for controlling cell phenotype.

In our approach, we used the differentiation of adult human mesenchymal stem cells (MSCs) into smooth muscle cells (SMCs) as a model system to investigate the relationship between cell shape and phenotype. These cell types are responsive to mechanical and biochemical stimuli and the shape of SMCs is a recognized marker of a differentiated state, providing a system in which morphological and biochemical phenotype are both understood and inducible. By applying exogenous stimuli, we changed cell shape and examined the corresponding cellular phenotype. In the first Aim, we applied stretch to MSCs on 2D collagen sheets to promote differentiation. Using mathematical shape factors, we quantified the morphological changes in response to defined stretch parameters. In the second Aim, we investigated the use of input energy as a means of controlling cell shape and corresponding differentiation. We examined how combinations of stretch parameters that produce equal energy input impacted morphology, and postulated that cell shape is a function of energy input. In the third Aim, we translated our method of quantifying shape factors into 3D culture, and validated the method by investigating the differentiation of MSCs into SMCs by mechanical and growth factor stimulation. We used relevant shape factors to quantify morphological differences and compared these changes to biochemical markers.

Our results demonstrate that mechanical stretch influences multiple aspects of MSC phenotype, including cell morphology. Shape factors described these changes objectively and quantitatively, and enabled the identification of relationships between SMC shape and differentiated state. Similar morphological responses could be induced using different combinations of stretch parameters that resulted in equal energy input. Cell shape followed a linear relationship with energy input despite the variance introduced by using MSCs from different patients. Only one SMC gene marker directly exhibited this relationship; however, partial least squares regression analysis revealed that other genes were also associated with shape factors. Translation of the shape quantification method into 3D collagen systems revealed that while the additional dimensionality hindered comparison of morphology between 2D and 3D samples, shape factor analysis was valid for relative studies within 3D systems. Differences in cell morphology caused by growth factors and mechanical stretch in 3D constructs were elucidated by shape analysis, and these phenotypic changes were corroborated through biochemical assays. Taken together, these results validate the use of cell shape as means of characterizing cell phenotype and the process of progenitor cell differentiation. The automated method we developed generates a robust set of morphological parameters that characterize the differentiation of MSCs into SMCs. This work has implications in our understanding of the relationship between cell morphology and phenotype, and may lead to new ways to control and improve differentiation efficiency in a variety of cell and tissue systems.

​Chair: Dr. ​Jan Stegemann​

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Other Sun, 15 Apr 2018 21:38:31 -0400 2018-04-24T10:00:00-04:00 2018-04-24T11:00:00-04:00 Lurie Robert H. Engin. Ctr Biomedical Engineering Other event
BME Master's Thesis Defense - Suraj Jaipalli (April 24, 2018 12:00pm) https://events.umich.edu/event/52038 52038-12373788@events.umich.edu Event Begins: Tuesday, April 24, 2018 12:00pm
Location: North Campus Recreation Building
Organized By: Biomedical Engineering

Discovering Synergistic and Antagonistic Drug Combinations for Mycobacterium Tuberculosis

With the rise of antibiotic resistance, treatments involving common frontline TB drugs have been rendered insufficient, especially in treating multidrug resistant (MDR) and extremely drug resistant (XDR) strains of TB. As new anti-TB therapies are beginning to emerge, optimizing specific combinations of individual agents into effective and safe regimens remains a significant challenge. To address this problem, we have developed a in-silico computational tool—Inferring Drug Interactions using chemo-Genomics and Orthology for MTB (INDIGO-MTB). INDIGO-MTB leverages high resolution MTB transcriptomic profiles and TB drug interaction data to predict synergy/antagonism of TB drug regimens with high accuracy. INDIGO-MTB uses the random forests machine learning algorithm to train its predictive model, which can be used to make predictions for synergy of novel TB drug regimens. INDIGO-MTB predictions correlated well with corresponding in-vitro drug interaction validation scores. The in-vitro INDIGO-MTB interaction scores were also predictive of the percentage of patients with negative sputum cultures after 8 weeks in clinical trials for 58 TB drug regimens. We hope INDIGO-MTB can be used by clinicians and researchers to quickly assess the likelihood of success of new TB drug combinations using publicly available data.

Chair: Sriram Chandrasekaran, Ph.D.

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Other Fri, 20 Apr 2018 13:42:24 -0400 2018-04-24T12:00:00-04:00 2018-04-24T13:00:00-04:00 North Campus Recreation Building Biomedical Engineering Other event
BME Master's Thesis Defense - Mingxiao Zhang (April 24, 2018 2:00pm) https://events.umich.edu/event/51949 51949-12321827@events.umich.edu Event Begins: Tuesday, April 24, 2018 2:00pm
Location: East Hall
Organized By: Biomedical Engineering

Department of Biomedical Engineering Master’s Thesis Defense

Mingxiao Zhang

Hardware Design, Integration and Optimization of a Virtual Reality Environment for Rodent Cortical Neuronal Recordings


Understanding neural circuits often requires innovative and custom-designed behavioral setups. A head-fixed virtual reality (VR) system for rodents offers a number of advantages in terms of being able to investigate and manipulate neural circuits involved in both normal behaviors and in pathological brain states. A complete VR experimental system to investigate cortical neurons of rodents consists of three vital parts: 1) a hardware system with recording and reward functionality; 2) a software system to process, analyze and report the signals and also to control the logical flow of experiments; 3) a hardware-software interface to link these two systems. The current project focused on the design of the hardware interface, the optimization of the communication between the software system and multiple hardware systems, the locomotion-recording system, and the displacement/speed analysis from the locomotion-recording system. This functional VR system has enabled high resolution neural recordings in the study of precise behaviors.

Chair: Tim Bruns, PhD.

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Lecture / Discussion Sun, 15 Apr 2018 21:34:26 -0400 2018-04-24T14:00:00-04:00 2018-04-24T15:00:00-04:00 East Hall Biomedical Engineering Lecture / Discussion event
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (April 24, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656547@events.umich.edu Event Begins: Tuesday, April 24, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-04-24T14:00:00-04:00 2018-04-24T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (April 25, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656591@events.umich.edu Event Begins: Wednesday, April 25, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-04-25T14:00:00-04:00 2018-04-25T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (April 30, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656637@events.umich.edu Event Begins: Monday, April 30, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-04-30T14:00:00-04:00 2018-04-30T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (May 1, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656548@events.umich.edu Event Begins: Tuesday, May 1, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-05-01T14:00:00-04:00 2018-05-01T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (May 2, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656592@events.umich.edu Event Begins: Wednesday, May 2, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-05-02T14:00:00-04:00 2018-05-02T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
International Conference for Advanced Neurotechnology (May 7, 2018 8:00am) https://events.umich.edu/event/51260 51260-12029936@events.umich.edu Event Begins: Monday, May 7, 2018 8:00am
Location: Gerald Ford Library
Organized By: Electrical and Computer Engineering

The annual International Conference for Advanced Neurotechnology (ICAN) brings together engineers and neuroscientists to review recent technological advancements in neurotechnology and neuroscience and to define the direction of the field in the generation and application of next-generation tools to advance neuroscience and enhance translation of technology to the science community.

Significant advances have occurred to address the problem of scaling neuroscience investigative tools to interface with neuronal circuits and in defining the properties of elemental cell types that comprise these circuits. Yet, these advances have not fully met the complexity, or fully addressed the cellular and network features of the CNS required to accelerate our understanding of the brain.

Program and Registration: http://eecs.umich.edu/ipan/ican2018.html

Co-chairs:
Euisik Yoon, Professor of Electrical Engineering and Computer Science, University of Michigan
Gyorgy Buzsaki, Biggs Professor of Neuroscience, New York University School of Medicine

Sponsors:
NSF International Program for the Advancement of Neurotechnology (IPAN), directed by Prof. Euisik Yoon
Integrated Neuromorphic Electronics and Microsystems (INEMS), directed by Prof. Wei Lu

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Conference / Symposium Wed, 21 Mar 2018 11:59:58 -0400 2018-05-07T08:00:00-04:00 2018-05-07T16:00:00-04:00 Gerald Ford Library Electrical and Computer Engineering Conference / Symposium ICAN logo and header
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (May 7, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656638@events.umich.edu Event Begins: Monday, May 7, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-05-07T14:00:00-04:00 2018-05-07T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
International Conference for Advanced Neurotechnology (May 8, 2018 8:30am) https://events.umich.edu/event/51260 51260-12029937@events.umich.edu Event Begins: Tuesday, May 8, 2018 8:30am
Location: Gerald Ford Library
Organized By: Electrical and Computer Engineering

The annual International Conference for Advanced Neurotechnology (ICAN) brings together engineers and neuroscientists to review recent technological advancements in neurotechnology and neuroscience and to define the direction of the field in the generation and application of next-generation tools to advance neuroscience and enhance translation of technology to the science community.

Significant advances have occurred to address the problem of scaling neuroscience investigative tools to interface with neuronal circuits and in defining the properties of elemental cell types that comprise these circuits. Yet, these advances have not fully met the complexity, or fully addressed the cellular and network features of the CNS required to accelerate our understanding of the brain.

Program and Registration: http://eecs.umich.edu/ipan/ican2018.html

Co-chairs:
Euisik Yoon, Professor of Electrical Engineering and Computer Science, University of Michigan
Gyorgy Buzsaki, Biggs Professor of Neuroscience, New York University School of Medicine

Sponsors:
NSF International Program for the Advancement of Neurotechnology (IPAN), directed by Prof. Euisik Yoon
Integrated Neuromorphic Electronics and Microsystems (INEMS), directed by Prof. Wei Lu

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Conference / Symposium Wed, 21 Mar 2018 11:59:58 -0400 2018-05-08T08:30:00-04:00 2018-05-08T14:00:00-04:00 Gerald Ford Library Electrical and Computer Engineering Conference / Symposium ICAN logo and header
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (May 8, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656549@events.umich.edu Event Begins: Tuesday, May 8, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-05-08T14:00:00-04:00 2018-05-08T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Microfluidics Symposium 2018 (May 9, 2018 10:00am) https://events.umich.edu/event/51028 51028-11942018@events.umich.edu Event Begins: Wednesday, May 9, 2018 10:00am
Location: North Campus Research Complex Building 10
Organized By: Biomedical Engineering

Register Here:
https://goo.gl/forms/baPeX6Mfk7PIfIuR2

Abstract Submission Deadline: March 27, 2018

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Other Tue, 13 Mar 2018 16:03:24 -0400 2018-05-09T10:00:00-04:00 2018-05-09T16:00:00-04:00 North Campus Research Complex Building 10 Biomedical Engineering Other event
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (May 9, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656593@events.umich.edu Event Begins: Wednesday, May 9, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-05-09T14:00:00-04:00 2018-05-09T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (May 14, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656639@events.umich.edu Event Begins: Monday, May 14, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-05-14T14:00:00-04:00 2018-05-14T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (May 15, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656550@events.umich.edu Event Begins: Tuesday, May 15, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-05-15T14:00:00-04:00 2018-05-15T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (May 16, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656594@events.umich.edu Event Begins: Wednesday, May 16, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-05-16T14:00:00-04:00 2018-05-16T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (May 21, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656640@events.umich.edu Event Begins: Monday, May 21, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-05-21T14:00:00-04:00 2018-05-21T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (May 22, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656551@events.umich.edu Event Begins: Tuesday, May 22, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-05-22T14:00:00-04:00 2018-05-22T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (May 23, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656595@events.umich.edu Event Begins: Wednesday, May 23, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-05-23T14:00:00-04:00 2018-05-23T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (May 28, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656641@events.umich.edu Event Begins: Monday, May 28, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-05-28T14:00:00-04:00 2018-05-28T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (May 29, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656552@events.umich.edu Event Begins: Tuesday, May 29, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-05-29T14:00:00-04:00 2018-05-29T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (May 30, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656596@events.umich.edu Event Begins: Wednesday, May 30, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-05-30T14:00:00-04:00 2018-05-30T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (June 4, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656642@events.umich.edu Event Begins: Monday, June 4, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-06-04T14:00:00-04:00 2018-06-04T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (June 5, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656553@events.umich.edu Event Begins: Tuesday, June 5, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-06-05T14:00:00-04:00 2018-06-05T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Precision Medicine World Conference (June 6, 2018 9:00am) https://events.umich.edu/event/52304 52304-12598004@events.umich.edu Event Begins: Wednesday, June 6, 2018 9:00am
Location: Ross School of Business
Organized By: Precision Health

The program will feature innovative technologies, and analyze the success of already thriving initiatives and clinical case studies that enable the translation of precision medicine into direct improvements in health care. Conference attendees will have an opportunity to learn first-hand about the latest developments and advances in precision medicine and cutting-edge strategies and solutions that are fundamentally changing how patients are treated. This is reflected in the Program Theme: “Big Data in Action: Insights in the Clinic”.

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Conference / Symposium Fri, 11 May 2018 09:49:58 -0400 2018-06-06T09:00:00-04:00 2018-06-06T17:00:00-04:00 Ross School of Business Precision Health Conference / Symposium Ross School of Business
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (June 6, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656597@events.umich.edu Event Begins: Wednesday, June 6, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-06-06T14:00:00-04:00 2018-06-06T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (June 11, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656643@events.umich.edu Event Begins: Monday, June 11, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-06-11T14:00:00-04:00 2018-06-11T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (June 12, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656554@events.umich.edu Event Begins: Tuesday, June 12, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-06-12T14:00:00-04:00 2018-06-12T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (June 13, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656598@events.umich.edu Event Begins: Wednesday, June 13, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-06-13T14:00:00-04:00 2018-06-13T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (June 18, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656644@events.umich.edu Event Begins: Monday, June 18, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-06-18T14:00:00-04:00 2018-06-18T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (June 19, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656555@events.umich.edu Event Begins: Tuesday, June 19, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-06-19T14:00:00-04:00 2018-06-19T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
The Role of Direct-to-Consumer Genetics in Patient Health (June 19, 2018 5:30pm) https://events.umich.edu/event/52407 52407-12704154@events.umich.edu Event Begins: Tuesday, June 19, 2018 5:30pm
Location: Taubman Library
Organized By: NextGen Med

NextGen Med presents "The Role of Direct-to-Consumer Genetics in Patient Health" with Robert Gentleman, PhD, Vice President of Computational Biology at 23andMe, and David Ginsburg, MD, Professor of Internal Medicine and Human Genetics at the University of Michigan.

Tuesday, June 19th, 2018
5:30 PM – 7:00 PM
2901 Taubman Health Sciences Library

Please join us for a discussion on direct-to-consumer genetic products, their impact on patient health, and the role 23andMe plays in the collection and use of genomic data.

This event is free, and we welcome all members of the University of Michigan community including students, faculty and staff. Please RSVP at https://goo.gl/oSJr2h

NextGen Med is a group of medical students committed to inviting local and global leaders to discuss current challenges in medicine with the UMMS community. We aim to expose future leaders in health care to today’s most pressing questions and tomorrow’s greatest innovations. We would like to thank the Leadership Curriculum within the medical school for their support. Additional Questions? Contact NextGenMed@umich.edu

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Lecture / Discussion Mon, 21 May 2018 13:34:07 -0400 2018-06-19T17:30:00-04:00 2018-06-19T19:00:00-04:00 Taubman Library NextGen Med Lecture / Discussion
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (June 20, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656599@events.umich.edu Event Begins: Wednesday, June 20, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-06-20T14:00:00-04:00 2018-06-20T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Research Education and Activities for Classroom Teachers (June 22, 2018 9:30am) https://events.umich.edu/event/51957 51957-12327241@events.umich.edu Event Begins: Friday, June 22, 2018 9:30am
Location: North Campus Research Complex Building 10
Organized By: American Chemical Society Polymer Division - Student Chapter

REACT is a one-day workshop for Michigan K-12 STEM teachers at the University of Michigan (Ann Arbor campus). This event provides K-12 STEM teachers free exposure to the impactful research being done at the University of Michigan through focused student talks, lab tours, and hands-on demonstrations by student organizations.

This year's REACT workshop includes research from Macromolecular Science and Engineering, Materials Science and Engineering, Environmental Sciences, Mechanical Engineering and Robotics, Electrical Engineering, Climate and Space Sciences and Engineering, Chemical Engineering, Human Genetics, and Physics.

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Workshop / Seminar Mon, 16 Apr 2018 09:25:00 -0400 2018-06-22T09:30:00-04:00 2018-06-22T17:00:00-04:00 North Campus Research Complex Building 10 American Chemical Society Polymer Division - Student Chapter Workshop / Seminar
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (June 25, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656645@events.umich.edu Event Begins: Monday, June 25, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-06-25T14:00:00-04:00 2018-06-25T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (June 26, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656556@events.umich.edu Event Begins: Tuesday, June 26, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-06-26T14:00:00-04:00 2018-06-26T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (June 27, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656600@events.umich.edu Event Begins: Wednesday, June 27, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-06-27T14:00:00-04:00 2018-06-27T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (July 2, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656646@events.umich.edu Event Begins: Monday, July 2, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-07-02T14:00:00-04:00 2018-07-02T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (July 3, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656557@events.umich.edu Event Begins: Tuesday, July 3, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-07-03T14:00:00-04:00 2018-07-03T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (July 4, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656601@events.umich.edu Event Begins: Wednesday, July 4, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-07-04T14:00:00-04:00 2018-07-04T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (July 9, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656647@events.umich.edu Event Begins: Monday, July 9, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-07-09T14:00:00-04:00 2018-07-09T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (July 10, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656558@events.umich.edu Event Begins: Tuesday, July 10, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-07-10T14:00:00-04:00 2018-07-10T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (July 11, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656602@events.umich.edu Event Begins: Wednesday, July 11, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-07-11T14:00:00-04:00 2018-07-11T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (July 16, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656648@events.umich.edu Event Begins: Monday, July 16, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-07-16T14:00:00-04:00 2018-07-16T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (July 17, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656559@events.umich.edu Event Begins: Tuesday, July 17, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-07-17T14:00:00-04:00 2018-07-17T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (July 18, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656603@events.umich.edu Event Begins: Wednesday, July 18, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-07-18T14:00:00-04:00 2018-07-18T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Ask A Scientist at Art Fair (July 21, 2018 10:00am) https://events.umich.edu/event/52908 52908-13142319@events.umich.edu Event Begins: Saturday, July 21, 2018 10:00am
Location: Off Campus Location
Organized By: Engaging Scientists in Policy and Advocacy

ESPA will have an Ask A Scientist booth at the Ann Arbor Art Fair on Saturday, July 21, and Sunday, July 22. Sign up to be at the booth (and get a t shirt), or stop by and talk to one of us! Register to be an advocate here: https://goo.gl/forms/YYAzJViB9wwtrkoF3

Booth is located with the other non-profit booths on Liberty St between 5th St and Division St. Look for Booth #55. Scientists may also be walking around wearing t-shirts - please stop us and strike up a conversation!

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Fair / Festival Mon, 16 Jul 2018 13:58:02 -0400 2018-07-21T10:00:00-04:00 2018-07-21T21:00:00-04:00 Off Campus Location Engaging Scientists in Policy and Advocacy Fair / Festival
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (July 23, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656649@events.umich.edu Event Begins: Monday, July 23, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-07-23T14:00:00-04:00 2018-07-23T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (July 24, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656560@events.umich.edu Event Begins: Tuesday, July 24, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-07-24T14:00:00-04:00 2018-07-24T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (July 25, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656604@events.umich.edu Event Begins: Wednesday, July 25, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-07-25T14:00:00-04:00 2018-07-25T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (July 30, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656650@events.umich.edu Event Begins: Monday, July 30, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-07-30T14:00:00-04:00 2018-07-30T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (July 31, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656561@events.umich.edu Event Begins: Tuesday, July 31, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-07-31T14:00:00-04:00 2018-07-31T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (August 1, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656605@events.umich.edu Event Begins: Wednesday, August 1, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-08-01T14:00:00-04:00 2018-08-01T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Single-Cell Data Analytics Symposium (August 6, 2018 8:30am) https://events.umich.edu/event/52442 52442-12724698@events.umich.edu Event Begins: Monday, August 6, 2018 8:30am
Location: Palmer Commons
Organized By: Michigan Institute for Data Science

Please join us for the second annual Single-cell Genomic Data Analytics Symposium. The day-long symposium will highlight researchers from U-M and around the world whose work is on the leading edge of innovation and discovery. This symposium is organized by the Michigan Center for Single-Cell Genomic Data Analytics and sponsored by the Michigan Institute for Data Science.

External speakers:
• Dana Pe’er, Scientific Director, GMTEC; Chair, Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center.
• Christina Kendziorski, Professor, Biostatistics and Medical Informatics, University of Wisconsin
• Peter Kharchenko, Assistant Professor of Biomedical Informatics Harvard Medical School
• Emma Lundberg, Visiting Associate Professor, Stanford University; Associate Professor, KTH Royal Institute of Technology

U-M Speakers:
• Johann Gagnon-Bartsch, Statistics, LSA • Xiang Zhou, Biostatistics, SPH
• Max Wicha, Forbes Institute for Cancer Discovery, Internal Medicine, Medical School
• Gil Omenn, Harold T. Shapiro Distinguished University Professor and Director, Center for Computational Medicine and Bioinformatics
• Jun Li, Human Genetics, Medical School
• Anna Gilbert, Mathematics, LSA
• Sue Hammoud, Human Genetics, MedicalSchool
• Justin Colacino, Environmental Health Sciences, SPH
• Clay Scott, Electrical Engineering and Computer Science, College of Engineering
• Lana Garmire (new faculty), Computational Medicine and Bioinformatics, Medical School
• Josh Welch (new faculty), Computational Medicine and Bioinformatics, Medical School

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Conference / Symposium Sun, 22 Jul 2018 11:14:53 -0400 2018-08-06T08:30:00-04:00 2018-08-06T16:30:00-04:00 Palmer Commons Michigan Institute for Data Science Conference / Symposium MIDAS logo
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (August 6, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656651@events.umich.edu Event Begins: Monday, August 6, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-08-06T14:00:00-04:00 2018-08-06T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (August 7, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656562@events.umich.edu Event Begins: Tuesday, August 7, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-08-07T14:00:00-04:00 2018-08-07T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
BME Coulter at Researchpalooza (August 8, 2018 11:00am) https://events.umich.edu/event/53517 53517-13392478@events.umich.edu Event Begins: Wednesday, August 8, 2018 11:00am
Location: Medical Science Unit I
Organized By: Biomedical Engineering

Come visit Coulter at #researchpalooza, tomorrow, Aug 8th from 11-2 pm in front of Med Sci I to find out how we help move medical innovation closer to the clinic and enter to win a Starbucks gift card! See you at tables 91 and 92.

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Fair / Festival Tue, 07 Aug 2018 15:04:34 -0400 2018-08-08T11:00:00-04:00 2018-08-08T14:00:00-04:00 Medical Science Unit I Biomedical Engineering Fair / Festival Coulter
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (August 8, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656606@events.umich.edu Event Begins: Wednesday, August 8, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-08-08T14:00:00-04:00 2018-08-08T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
BME PhD Defense: Sydney Williams (August 9, 2018 10:00am) https://events.umich.edu/event/53244 53244-13321606@events.umich.edu Event Begins: Thursday, August 9, 2018 10:00am
Location: Lurie Robert H. Engin. Ctr
Organized By: Biomedical Engineering

Constrained and Spectral-Spatial RF Pulse Design for Magnetic Resonance Imaging



Magnetic resonance imaging (MRI) is a critical tool for modern medicine, providing a non-invasive glimpse inside the human body with excellent soft tissue contrast and no ionizing radiation. The radio frequency (RF) pulse in an MRI acquisition is integral to producing an image and can be tailored to particular applications. This thesis focuses on the design of RF pulses and explores the MRI physics, convex optimization problems, and experimental methodologies behind doing so.



First, we introduce constrained RF pulse design which enables efficient RF pulse design with meaningful, physical constraints such as peak RF amplitude and integrated RF power. We explore constrained RF pulse design for simultaneous multislice imaging, a powerful tool for accelerating MRI and combatting notoriously long acquisition times. Compared to a conventional simultaneous multislice pulse designed without constraints, our constrained pulses achieved lower magnitude normalized root mean squared error (NRMSE) for an equivalent RF pulse length, or alternatively, the same NRMSE for a shorter pulse length. Constrained RF pulse design forms a basis for the rest of the dissertation.



Secondly, we describe a special class of RF pulses, “prewinding pulses”, that help correct for intravoxel dephasing due to magnetic field inhomogeneity, that can lead to signal loss. We propose a spectral-spatial prewinding pulse that leverages a larger effective recovery bandwidth than equivalent, purely spectral pulses. In an in vivo experiment imaging the brain of a human volunteer, we designed spectral-spatial pulses with a complex NMRSE of 0.18, which is significantly improved from the complex NRMSE of 0.54 in the purely spectral pulse for the same experiment.



Finally, we consider a slab-selective prewinding pulse, that extends spectral and spectral-spatial prewinding pulses to a common 3D imaging method. Here we integrate optimal control optimization to further improve the slab-selective spectral pulse design and see an in vivo improvement of excitation NRMSE from 0.40 to 0.37 and a major reduction in mean residual magnetization magnitude after a tip-up pulse from 0.18 to 0.02 when adding optimal control. This method has the potential to connect prewinding pulse design from the MRI physicist engineering workspace to a clinical application.

In summary, we show that constrained RF pulse design provides an efficient way of improving MRI in terms of acquisition speed (via multislice imaging) and image quality (via signal recovery).

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Presentation Mon, 06 Aug 2018 10:05:33 -0400 2018-08-09T10:00:00-04:00 2018-08-09T11:00:00-04:00 Lurie Robert H. Engin. Ctr Biomedical Engineering Presentation BME-EVENT Placeholder
BME PhD Defense: Tuğba Topal (August 10, 2018 1:00pm) https://events.umich.edu/event/53267 53267-13330229@events.umich.edu Event Begins: Friday, August 10, 2018 1:00pm
Location: North Campus Research Complex Building 10
Organized By: Biomedical Engineering

The Effects of Mechanical Forces on Human Embryonic Stem Cell Behavior



The development of an organism from a zygote into a fully functional 3D individual is a process in which a strong coupling of morphogens and mechanical forces is coordinated with embryo shape. During development, cells communicate with each other through cell-cell junctions and with their microenvironment via mechanical cues to regulate cell fate, re-organize the extracellular matrix, and guide developmental process. Most studies on human embryonic stem cells (hESCs) focused on how external soluble factors including growth factors and small inhibitors, gene and protein expression, and signaling pathways to maintain stemness or initiate differentiation of these cells. A various array of environmental factors including the effect of geometry and mechanical properties of extracellular matrix on stem cells contributes to altering stem cell fate. Recently, increasing evidence has revealed the importance of mechanical factors in affecting migration, proliferation and stem cell differentiation in vitro.



In this dissertation, we focus on the development and application of novel bioengineering approaches to understand the effects of mechanical forces on hESC behaviors and the directed differentiation of hESCs. Specifically, by employing a microfluidic device to induce controlled and regulated forces that apply global mechanical forces to adherent hESCs, we find that uniaxial substrate stretching disrupts the pluripotency circuit and initiates the exit of transcription factors, Nanog and Oct4, from the nucleus into the cytoplasm via a nuclear export protein (CRM1) as early as 30 min after stretch application and for 2 hours on a flexible substrate coated with Matrigel, and is not reliant on exogenous soluble factors. In order to pinpoint to the receptors responsible for mechanical sensing, we employ a novel technique, acoustic tweezing cytometery (ATC), that utilizes ultrasound pulses to actuate functionalized microbubbles targeted to integrin in order to apply cyclic strain to hESCs. We find that ATC-mediated cyclic forces applied for 30 min induced immediate global responses in the colony, including increased contractile force, enhanced calcium activity, as well as decreased nuclear expression of pluripotency transcription factors Oct4 and Nanog, leading to rapid differentiation and characteristic epithelial-mesenchymal transition (EMT) events that depend on focal adhesion kinase activation and cytoskeleton tension. These results reveal a unique, rapid mechanoresponsiveness and community behavior of hESCs to integrin-targeted cyclic forces. Furthermore, we demonstrate an integrative mechanotransduction that induced neural rosette formation of hESCs via the application of ATC and induction medium. We observe upregulation of Pax6 and Sox1 in as early as 6 hours, following by neural rosettes formation in 48 hours, which is much faster compared to the typical 10-15 days needed with conventional neural rosettes formation protocols.



Together, this dissertation presents novel findings and insights regarding the effects of external mechanical forces on hESCs. Such information may help elucidate the mechanobiology of hESCs, and thus advance our knowledge of human embryogenesis, regenerative medicine, and tissue engineering.

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Presentation Tue, 31 Jul 2018 08:53:18 -0400 2018-08-10T13:00:00-04:00 2018-08-10T14:00:00-04:00 North Campus Research Complex Building 10 Biomedical Engineering Presentation BME-EVENT Placeholder
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (August 13, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656652@events.umich.edu Event Begins: Monday, August 13, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-08-13T14:00:00-04:00 2018-08-13T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (August 14, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656563@events.umich.edu Event Begins: Tuesday, August 14, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-08-14T14:00:00-04:00 2018-08-14T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (August 15, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656607@events.umich.edu Event Begins: Wednesday, August 15, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-08-15T14:00:00-04:00 2018-08-15T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
BME PhD Defense: Steven M. Peterson (August 17, 2018 10:30am) https://events.umich.edu/event/53424 53424-13381393@events.umich.edu Event Begins: Friday, August 17, 2018 10:30am
Location: Lurie Robert H. Engin. Ctr
Organized By: Biomedical Engineering

Humans must frequently adapt their posture to prevent loss of balance. Such balance control requires complex, precisely-timed coordination among sensory input, neural processing, and motor output. Despite its importance, our current understanding of cortical involvement during balance control remains limited by traditional neuroimaging methods, which are stationary and have poor time resolution. High-density electroencephalography (EEG), combined with independent component analysis, has become a promising tool for recording cortical dynamics during balance perturbations due to its portability and high temporal resolution. Additionally, recent improvements in immersive virtual reality headsets may provide new rehabilitative paradigms, but the effects of virtual reality on balance and cortical function remain poorly understood.

In my first study, I recorded high-density EEG from healthy, young adult subjects as they walked along a beam with and without virtual reality high heights exposure. While virtual high heights did induce stress, the use of virtual reality during the task increased performance errors and EEG measures of cognitive loading compared to real-world viewing without a headset. In my second study, I collected high-density EEG from healthy young adults as they walked along a treadmill-mounted balance beam to determine the effect of a transient visual perturbation on training in virtual reality. Subjects in the perturbations group improved comparably to those that trained without virtual reality, indicating that the perturbation helped subjects overcome the negative effects of virtual reality on motor learning. The perturbation primarily elicited a cognitive change. In my third study, healthy, young adult EEG was recorded during physical pull and visual rotation perturbations to tandem walking and tandem standing. I found similar electrocortical patterns for both perturbation types, but different cortical areas were involved for each. In my fourth study, I used a phantom head to validate EEG connectivity methods based on Granger causality in a real-world environment. In general, connectivity measures could determine the underlying connections, but many were susceptible to high-frequency false positives. Using data from my third study, my fifth study analyzed corticomuscular connectivity patterns following sensorimotor balance perturbations. I found strong occipito-parietal connections regardless of perturbation type, along with evidence of direct muscular control from the supplementary motor area during the standing perturbation response.

Taken together, the work presented in this dissertation greatly expands upon the current knowledge of cortical processing during sensorimotor balance perturbations and the effect of such perturbations on short-term motor learning, providing multiple avenues for future exploration.

CO-CHAIRS: Dr. Cynthia Chestek and Dr. Daniel P. Ferris

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Lecture / Discussion Mon, 06 Aug 2018 10:12:36 -0400 2018-08-17T10:30:00-04:00 2018-08-17T11:30:00-04:00 Lurie Robert H. Engin. Ctr Biomedical Engineering Lecture / Discussion BME
BME PhD Defense: Grant Hanada (August 17, 2018 1:30pm) https://events.umich.edu/event/53562 53562-13407924@events.umich.edu Event Begins: Friday, August 17, 2018 1:30pm
Location: Lurie Robert H. Engin. Ctr
Organized By: Biomedical Engineering

Mobile brain and body imaging (MoBI) presents new and promising methods for moving traditional research studies out of a controlled laboratory and into the real world. Most current neuroimaging techniques require subjects to be stationary in laboratory settings because of both hardware and software limitations. Recent developments in mobile brain imaging have utilized Electroencephalography (EEG) in conjunction with advanced signal processing techniques such as Independent Component Analysis (ICA) to overcome these obstacles and study humans doing complex tasks in non-traditional environments. In my first study, I used high density EEG to examine the cortical dynamics of subjects walking on a split-belt treadmill with legs moving independently of each other at different speeds to investigate how humans adapt to novel perturbations. I found significantly increased low and high frequency spectral power across all sensorimotor and parietal neural sources during split-belt adaptation compared to normal walking, which provides insight into the brain areas and patterns used to accommodate locomotor adaptation. In my second study I combined multi-modal sensing and biometric devices including EEG, eye tracking, heart rate, accelerometers, and salivary cortisol into a portable setup that subjects wore indoors on a treadmill using virtual reality as well as outdoors in a public arboretum. Subjects walked for 1 hour each indoors and outdoors while completing a free viewing visual search oddball task in virtual reality and in real life. I reported on the methods for how to set this experiment up, synchronize all data, and standardize the data in order to make it usable as an open access dataset that has been made available to the public online. My third study used this data set to examine the P300 event-related potential response during both indoors in virtual reality and outdoors in the arboretum. I found a significantly increased P300 amplitude response across the centro-parietal electrodes that distinguished target flags from distractor flags during visual search for both indoor and outdoor environments. And finally, for my fourth study I used the same data set to look at the behavioral and neural correlates associated with gait dynamics when subjects walked indoors on a treadmill vs outdoors in variable terrain while also doing the visual search task. I found significant EEG power differences across multiple neural sources that showed increased spectral fluctuations throughout the gait cycle when subjects walked outdoors compared to indoors on a treadmill.

The collective studies in this dissertation present new ways of using mobile brain and body imaging devices to expand our knowledge of the neural dynamics involved in humans moving in complex ways and in variable environments outside of traditional laboratories.

DATE: Friday, August 17, 2018
TIME: 1:30 PM
LOCATION: General Motors Conference Room, Lurie Engineering Center (4th floor)
CO-CHAIRS: Dr. Cynthia Chestek and Dr. Daniel P. Ferris

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Lecture / Discussion Thu, 09 Aug 2018 09:24:16 -0400 2018-08-17T13:30:00-04:00 2018-08-17T14:30:00-04:00 Lurie Robert H. Engin. Ctr Biomedical Engineering Lecture / Discussion BME
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (August 20, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656653@events.umich.edu Event Begins: Monday, August 20, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-08-20T14:00:00-04:00 2018-08-20T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (August 21, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656564@events.umich.edu Event Begins: Tuesday, August 21, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-08-21T14:00:00-04:00 2018-08-21T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (August 22, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656608@events.umich.edu Event Begins: Wednesday, August 22, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-08-22T14:00:00-04:00 2018-08-22T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (August 27, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656654@events.umich.edu Event Begins: Monday, August 27, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-08-27T14:00:00-04:00 2018-08-27T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (August 28, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656565@events.umich.edu Event Begins: Tuesday, August 28, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-08-28T14:00:00-04:00 2018-08-28T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (August 29, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656609@events.umich.edu Event Begins: Wednesday, August 29, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-08-29T14:00:00-04:00 2018-08-29T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (September 3, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656655@events.umich.edu Event Begins: Monday, September 3, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-09-03T14:00:00-04:00 2018-09-03T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (September 4, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656566@events.umich.edu Event Begins: Tuesday, September 4, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-09-04T14:00:00-04:00 2018-09-04T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (September 5, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656610@events.umich.edu Event Begins: Wednesday, September 5, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-09-05T14:00:00-04:00 2018-09-05T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
LGBTQ Inclusion as Researchers & In Research (September 6, 2018 7:30am) https://events.umich.edu/event/52597 52597-12868040@events.umich.edu Event Begins: Thursday, September 6, 2018 7:30am
Location: Rackham Graduate School (Horace H.)
Organized By: Michigan Institute for Clinical & Health Research (MICHR)

By attending this symposium, participants will:

Learn about the range of LGBTQ research/scholarship at the University of Michigan and special issues with research/scholarship related to LGBTQ people.

Understand special issues that may affect researchers/scholars in any field who identify as LGBTQ and how to address these issues in developing a career in research.

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Conference / Symposium Thu, 07 Jun 2018 15:51:36 -0400 2018-09-06T07:30:00-04:00 2018-09-06T16:30:00-04:00 Rackham Graduate School (Horace H.) Michigan Institute for Clinical & Health Research (MICHR) Conference / Symposium L G B T Q symposium
“Molecular Imaging and Cellular Manipulation in Immuno-engineering” (September 6, 2018 9:00am) https://events.umich.edu/event/53897 53897-13476566@events.umich.edu Event Begins: Thursday, September 6, 2018 9:00am
Location: Chrysler Center
Organized By: Biomedical Engineering

Abstract:

Genetically-encoded biosensors based on fluorescence proteins (FPs) and fluorescence resonance energy transfer (FRET) have enabled the specific targeting and visualization of signaling events in live cells with high spatiotemporal resolutions. Single-molecule FRET biosensors have been successfully developed to monitor the activity of a variety of signaling molecules, including tyrosine/serine/threonine kinases. We have a developed a general high-throughput screening (HTS) method based on directed evolution to develop sensitive and specific FRET biosensors. We have first applied a yeast library and screened for a mutated binding domain for phosphorylated peptide sequence. When this mutated binding domain and the peptide sequence are connected by a linker and then concatenated in between a pair of FRET FPs, a drastic increase in sensitivity can be achieved. It has also been increasingly clear that controlling protein functions using lights and chemical compounds to trigger allosteric conformational changes can be applied to manipulate protein functions and control cellular behaviors. In this work, we first engineered a novel class of machinery molecules which can provide a surveillance of the intracellular space, visualizing the spatiotemporal patterns of molecular events and automatically triggering corresponding molecular actions to guide cellular functions. We have adopted a modular assembly approach to develop these machinery molecules. As a proof-of-concept, we engineered such a molecule for the sensing of intracellular tyrosine phosphorylation based on fluorescence resonance energy transfer (FRET) and the consequent activation of a tyrosine phosphatase (PTP) Shp2, which plays a critical and positive role in various pathophysiological processes. We have further integrated this machinery molecule to the “don’t eat me” CD47 receptor SIRPa on macrophages such that the engagement of SIRPa and its activation of naturally negative signals will be rewired to turn on the positive Shp2 action to facilitate phagocytosis of red blood cells and target tumor cells, initiated by the specific antigen-targeting antibodies and their interaction with Fcg receptors. Because of the modular design of our engineered molecule, our approach can be extended to perform a broad range of cell-based imaging and immunotherapies, and hence highlight the translational power in bridging the fundamental molecular engineering to clinical medicine. We have also integrated with lights and ultrasound to manipulate the molecular activation of genes and enzymes, which allowed us to control the cellular functions of immunocells with high precision in space and time. As such, we can integrate fundamental science and engineering principles for biomedical and clinical applications.

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Lecture / Discussion Fri, 17 Aug 2018 10:43:44 -0400 2018-09-06T09:00:00-04:00 2018-09-06T10:00:00-04:00 Chrysler Center Biomedical Engineering Lecture / Discussion BME
"Bimolecular Concert at the Cell Membrane Interface" (September 7, 2018 4:00pm) https://events.umich.edu/event/53436 53436-13381405@events.umich.edu Event Begins: Friday, September 7, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Physicochemical and structural properties of molecules at the cell membrane interface are crucial for cellular and other biological functions, and are implicated in numerous diseases including amyloid diseases and bacterial/viral infection. While it is obvious that such properties must be fully characterized for biotechnological and biomedical purposes, the intrinsic complexity of the lipid bilayer environment poses tremendous challenges to most biophysical techniques and biochemical approaches. The Ramamoorthy group has been developing novel membrane mimetics and biophysical (including NMR) approaches to overcome these challenges, and apply them to investigate dynamic structures of membrane proteins and membrane-assisted amyloid aggregation processes. The Biophysical Concert will focus on the following specific topics to highlight the challenges and recent advances:

*Advantages and limitations of "sushi-like" lipid-nanodiscs (Ravula)
*Probing atomic-resolution "hugs and kisses" that enable enzymatic function (Gentry)
*Capturing the amyloid-ghosts red-handed by nanodiscs (Sahoo)
*Atomic-resolution "weed-and-feed" action of amyloid-inhibitors (Cox)

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Workshop / Seminar Thu, 30 Aug 2018 15:05:49 -0400 2018-09-07T16:00:00-04:00 2018-09-07T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (September 10, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656656@events.umich.edu Event Begins: Monday, September 10, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-09-10T14:00:00-04:00 2018-09-10T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
General Electric Corporate Information Session (September 10, 2018 6:00pm) https://events.umich.edu/event/54582 54582-13601159@events.umich.edu Event Begins: Monday, September 10, 2018 6:00pm
Location: GG Brown Laboratory
Organized By: Society of Women Engineers

Description:Positions: Full-Time, Intern, Co-op
Majors: All Engineering Majors
Degrees: Undergraduate, Masters
Citizenship: US Citizen
Resumes: No

GE drives the world forward by tackling its biggest challenges: Energy, health, transportation. For more than 125 years, GE has invented the future of industry.

*Food will be provided!
Contact: Society of Women Engineers (swe.cis-ind.publicity@umich.edu)

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Careers / Jobs Mon, 03 Sep 2018 11:24:52 -0400 2018-09-10T18:00:00-04:00 2018-09-10T19:30:00-04:00 GG Brown Laboratory Society of Women Engineers Careers / Jobs GG Brown Laboratory
Delta Air Lines Corporate Information Session (September 10, 2018 6:30pm) https://events.umich.edu/event/54583 54583-13601160@events.umich.edu Event Begins: Monday, September 10, 2018 6:30pm
Location: Herbert H. Dow Building
Organized By: Society of Women Engineers

Description:Positions: Full-Time, Intern
Majors: All Engineering Majors
Degrees: Bachelor, Masters
Citizenship: US Citizen or Permanent Resident
Resumes: Yes

#1 U.S Airline based in Atlanta, GA

*Food will be provided!
Contact: Society of Women Engineers (swe.cis-ind.publicity@umich.edu)

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Careers / Jobs Mon, 03 Sep 2018 11:25:51 -0400 2018-09-10T18:30:00-04:00 2018-09-10T20:00:00-04:00 Herbert H. Dow Building Society of Women Engineers Careers / Jobs Herbert H. Dow Building
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (September 11, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656567@events.umich.edu Event Begins: Tuesday, September 11, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-09-11T14:00:00-04:00 2018-09-11T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Bioethics Discussion: Neuroethics (September 11, 2018 7:00pm) https://events.umich.edu/event/49420 49420-11453762@events.umich.edu Event Begins: Tuesday, September 11, 2018 7:00pm
Location: Lurie Biomedical Engineering
Organized By: The Bioethics Discussion Group

A roundtable discussion on the origins of our moral situation.

Readings to consider:
"Neuroethics: an agenda for neuroscience and society"
"Neuroethics: the practical and the philosophical"
"Neuroethics for the new millennium"

For more information and/or to receive a copy of the readings contact Barry Belmont at belmont@umich.edu or visit https://belmont.bme.umich.edu/bioethics-discussion-group/discussions/.

Please also swing by the blog: https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Fri, 29 Jun 2018 05:39:23 -0400 2018-09-11T19:00:00-04:00 2018-09-11T20:30:00-04:00 Lurie Biomedical Engineering The Bioethics Discussion Group Lecture / Discussion Neuroethics
BME PhD Defense: Diana Dillstrom (September 12, 2018 2:00pm) https://events.umich.edu/event/54489 54489-13589890@events.umich.edu Event Begins: Wednesday, September 12, 2018 2:00pm
Location: Rackham Graduate School (Horace H.)
Organized By: Biomedical Engineering

Osteogenesis imperfecta (OI) is a genetic disorder caused by collagen-related mutations which leads to increased bone fragility and low bone mass. Although the past decade has been marked by numerous advances in therapies that aim to stabilize the onset of metabolic bone disease, current treatment strategies leave room for substantial improvements. The studies that will be presented in this thesis focus on designing systematic treatments for two challenging clinical scenarios that require novel approaches. All studies have been approached in the context of OI using the Brtl/+ mouse model.

While the maternal skeleton goes through significant bone loss during pregnancy and lactation, this period of skeletal vulnerability can exacerbate an underlying metabolic bone condition like OI. In view of increasing use of bisphosphonates (BP) in premenopausal women to treat OI, the potential risks from long-term exposure on both maternal and neonatal skeleton during pregnancy and lactation remain inconclusive. When we assessed the maternal skeletal changes during pregnancy and lactation in Brtl/+ dams, pregnancy led to maternal trabecular gains in vertebral bone mass, while lactation induced maternal cortical and trabecular bone loss in both vertebra and femur. When BPs were administered prior to conception, bone mass gains due to pregnancy were amplified and lactation-induced bone loss was prevented. However, this protective effect was more modest with BP intervention during pregnancy, and ceased to exist in the late stages of lactation. Despite preventing lactation-induced maternal bone loss, no negative skeletal effects of BPs on offspring were observed. These findings indicate that during this period of significant imbalance between bone resorption and formation, BPs can help reduce the risk of maternal bone fragility in OI by inhibiting lactation-induced bone resorption without affecting bone development in their offspring.

The second half of this thesis explores clinical cases with a critically depleted bone structure, such as severe OI. These cases pose a challenge to current antiresorptive and anabolic therapeutics since their response mechanisms target different abnormalities in the bone remodeling cycle. In this study, rapidly growing Brtl/+ mice were treated with a combination of pamidronate (PAM) and an anabolic (SclAb) in order to attain superior bone mass and strength effects compared to monotherapy. Results from this study showed that following one cycle of combination therapy, a single dose of PAM in combination with SclAb led to a cumulative effect on bone mass, but each through independent means. PAM retention mechanism led to an increase in trabecular number as the dosage increased while no additional gains were observed with SclAb. Conversely, while PAM showed no significant effect on trabecular thickness, SclAb induced a consistent trabecular thickening across all BP dosages. Chronic effects of concurrent administration of BP and SclAb revealed that accumulating cycles conferred synergistic gains in trabecular mass and vertebral stiffness, suggesting a distinct advantage of both therapies combined.

Given the lack of knowledge regarding the effects of BPs during reproductive periods and lack of treatment options for patients with severe OI, this thesis provides valuable insight that can help develop patient-specific treatment plans. By understanding the changes in bone metabolism of the clinical conditions we are trying to resolve, and by combining this knowledge with our understanding of the targeted pathways of available pharmaceuticals, we can strategically and systematically optimize bone therapeutics so that the best clinical outcome can be achieved.

DATE: Wednesday, September 12, 2018
TIME: 2:00 PM
LOCATION: Earl Lewis Room in Rackham Building
CHAIR: Dr. Kenneth Kozloff

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Lecture / Discussion Thu, 30 Aug 2018 10:50:02 -0400 2018-09-12T14:00:00-04:00 2018-09-12T15:00:00-04:00 Rackham Graduate School (Horace H.) Biomedical Engineering Lecture / Discussion BME
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (September 12, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656611@events.umich.edu Event Begins: Wednesday, September 12, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-09-12T14:00:00-04:00 2018-09-12T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Seizert Capital Corporate Information Session (September 12, 2018 6:00pm) https://events.umich.edu/event/54641 54641-13625341@events.umich.edu Event Begins: Wednesday, September 12, 2018 6:00pm
Location: Herbert H. Dow Building
Organized By: Society of Women Engineers

Description:Positions: Full-Time, Intern, Co-op
Majors: All Engineering Majors
Degrees: Undergraduate, Masters, PhD
Citizenship: US Citizen
Resumes: Yes

Stocks, Investing, Trading, Programming

*Food will be provided!
Contact: Society of Women Engineers (swe.cis-ind.publicity@umich.edu)

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Careers / Jobs Mon, 03 Sep 2018 11:36:13 -0400 2018-09-12T18:00:00-04:00 2018-09-12T19:30:00-04:00 Herbert H. Dow Building Society of Women Engineers Careers / Jobs Herbert H. Dow Building
Applied Predictive Technologies Corporate Information Session (September 12, 2018 6:30pm) https://events.umich.edu/event/54642 54642-13625342@events.umich.edu Event Begins: Wednesday, September 12, 2018 6:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Society of Women Engineers

Positions: Full-Time, Intern
Majors: All Engineering Majors
Degrees: Bachelor, Masters
Citizenship: None
Resumes: Yes

Analytics Software Company

*Food will be provided!
Contact: Society of Women Engineers (swe.cis-ind.publicity@umich.edu)

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Careers / Jobs Mon, 03 Sep 2018 11:37:56 -0400 2018-09-12T18:30:00-04:00 2018-09-12T20:00:00-04:00 Electrical Engineering and Computer Science Building Society of Women Engineers Careers / Jobs Electrical Engineering and Computer Science Building
The Joseph and Sally Handleman Lecture Series presents Neri Oxman (September 12, 2018 6:30pm) https://events.umich.edu/event/53456 53456-13383550@events.umich.edu Event Begins: Wednesday, September 12, 2018 6:30pm
Location: Hill Auditorium
Organized By: Michigan Ross

What does innovation look like when we dissolve the borders between artistic creativity and the scientific method, speculative design and applied engineering, and problem solving and problem seeking? Find out Wednesday, September 12, as we host Neri Oxman on campus! An award-winning designer, architect, and director of the Mediated Matter Group at MIT, Neri’s work transcends the traditional boundaries between art, science, and nature.

This event is free and open to the public.

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Lecture / Discussion Mon, 06 Aug 2018 14:18:35 -0400 2018-09-12T18:30:00-04:00 2018-09-12T20:00:00-04:00 Hill Auditorium Michigan Ross Lecture / Discussion The Joseph and Sally Handleman Lecture Series presents Neri Oxman
Improving Intracortical Microelectrode Interface Utilizing Nano-Architecture (September 13, 2018 9:00am) https://events.umich.edu/event/54258 54258-13563460@events.umich.edu Event Begins: Thursday, September 13, 2018 9:00am
Location: Chrysler Center
Organized By: Biomedical Engineering

Abstract: Intracortical microelectrodes provide a means to both treat and understand diseases and injuries of the nervous systems. A major hurdle to the clinical deployment of microelectrode technologies is recording instability caused by the neuroinflammatory response and lack of integration with the native tissue. The neuroinflammatory response observed after device implantation has been linked to oxidative stress that occurs due to neurological injury and disease. It is important to improve the understanding of the neuroinflammatory and oxidative stress response in order to develop next generation electrodes and treatment strategies. A potential strategy to mitigate this response involves understanding the disparity in architecture between the in vivo environment and commercially available intracortical microelectrodes. The smooth surface structure of intracortical microelectrodes implanted within the nanometer-scale architecture of brain tissue may contribute to the foreign body response. The factors examined in Dr. Ereifej’s work and how they are utilized to inform the future design of compatible intracortical microelectrodes will be discussed.

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Lecture / Discussion Mon, 27 Aug 2018 08:51:46 -0400 2018-09-13T09:00:00-04:00 2018-09-13T10:00:00-04:00 Chrysler Center Biomedical Engineering Lecture / Discussion BME
Taubman Technology Talks (September 13, 2018 5:00pm) https://events.umich.edu/event/54149 54149-13530692@events.umich.edu Event Begins: Thursday, September 13, 2018 5:00pm
Location: Frankel Cardiovascular Center
Organized By: A. Alfred Taubman Medical Research Institute

Fei Wen, PhD, Dow Corning Assistant Professor, Department of Chemical Engineering will present, ““A 40-parameter view of the immune landscape at single-cell resolution…and other cool things you can do with CyTOF!” in the inaugural Taubman Technology Talk.

Her presentation will be 5-5:45 pm followed by a 15-min.question and answer period. A reception will follow from 6-7 pm.

The Taubman Technology Talks is a new series sponsored by the Taubman Institute, that aims to inform the UM community about the ongoing advances in technologies. All welcome; please join us!

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Lecture / Discussion Thu, 23 Aug 2018 15:51:51 -0400 2018-09-13T17:00:00-04:00 2018-09-13T19:00:00-04:00 Frankel Cardiovascular Center A. Alfred Taubman Medical Research Institute Lecture / Discussion TechTalk Sept 13 flyer
Seminar Title: "Magnetic Resonance Studies of Membrane Proteins" (September 14, 2018 4:00pm) https://events.umich.edu/event/53437 53437-13381406@events.umich.edu Event Begins: Friday, September 14, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: CW and pulsed Electron Paramagnetic Resonance (EPR) spectroscopic techniques coupled with site-directed spin-labeling (SDSL) can provide important structural information on complicated biological systems such as membrane proteins. Strategically placed spin-labels alter relaxation times of NMR active nuclei and yield pertinent structural information. EPR techniques such as Double Electron-Electron Resonance (DEER) and Electron Spin Echo Envelope Modulation (ESEEM) are powerful structural biology tools. The DEER technique can be used to measure distances between 2 spin labels from 20 to 70 Å. However, the application of DEER spectroscopy to study membrane proteins can be difficult due to short phase memory times (Tm) and weak DEER modulation in more biologically relevant proteoliposomes when compared to water soluble proteins or membrane proteins in detergent micelles. The combination of these factors often leads to broad distance distributions, poor signal to noise, and limitations in the determination of longer distances. The short phase memory times are typically due to uneven distributions of spin-labeled protein within the lipid bilayer, which creates local inhomogeneous pockets of high spin concentrations. Approaches to overcome these limitations and improve the quality of DEER measurements for membrane proteins will be discussed: lipodisq nanoparticles, bi-functional spin labels (BSL), and Q-band pulsed EPR spectroscopy. ESEEM data will be shown to probe the secondary structure of membrane proteins. CW-EPR spectra of spin-labeled membrane proteins will be used to investigate dynamics and the immersion depth in a lipid bilayer.

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Workshop / Seminar Thu, 30 Aug 2018 16:29:54 -0400 2018-09-14T16:00:00-04:00 2018-09-14T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Gary Lorigan
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (September 17, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656657@events.umich.edu Event Begins: Monday, September 17, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-09-17T14:00:00-04:00 2018-09-17T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Exxon Mobil Corporate Information Session (September 17, 2018 6:00pm) https://events.umich.edu/event/54643 54643-13627520@events.umich.edu Event Begins: Monday, September 17, 2018 6:00pm
Location: Cooley Building
Organized By: Society of Women Engineers

Positions: Full-Time, Intern, Co-op
Majors: All Engineering Majors
Degrees: Bachelor, Masters, PhD
Citizenship: US Citizen or Permanent Resident
Resumes: Yes

Energy Company

*Food will be provided!
Contact: Society of Women Engineers (swe.cis-ind.publicity@umich.edu)

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Careers / Jobs Mon, 03 Sep 2018 12:01:05 -0400 2018-09-17T18:00:00-04:00 2018-09-17T19:30:00-04:00 Cooley Building Society of Women Engineers Careers / Jobs Cooley Building
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (September 18, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656568@events.umich.edu Event Begins: Tuesday, September 18, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-09-18T14:00:00-04:00 2018-09-18T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (September 19, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656612@events.umich.edu Event Begins: Wednesday, September 19, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-09-19T14:00:00-04:00 2018-09-19T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
MIT Lincoln Laboratory Corporate Information Session (September 19, 2018 6:00pm) https://events.umich.edu/event/54652 54652-13627528@events.umich.edu Event Begins: Wednesday, September 19, 2018 6:00pm
Location: Herbert H. Dow Building
Organized By: Society of Women Engineers

Description:Positions: Full-Time, Intern
Majors: All Engineering Majors
Degrees: Bachelors
Citizenship: None
Resumes: Yes

At MIT Lincoln Laboratory, diverse teams of technical experts develop groundbreaking solutions to problems of national security. Our R&D efforts span ten key mission areas: space control; air, missile, & maritime defense technology; communication systems; cyber security and information sciences; intelligence, surveillance, and reconnaissance systems technology; advanced technology (electronic or electro-optical technologies, biotechnology and chemistry); tactical systems; homeland protection; air traffic control; and engineering innovative systems to test new concepts. For agile thinkers, excited by the freedom to develop and execute novel ideas and test them in sophisticated real-world simulations, Lincoln Laboratory offers abundant opportunities and resources. Learn more at www.ll.mit.edu.

*Food will be provided!
Contact: Society of Women Engineers (swe.cis-ind.publicity@umich.edu)

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Careers / Jobs Mon, 03 Sep 2018 12:26:42 -0400 2018-09-19T18:00:00-04:00 2018-09-19T19:30:00-04:00 Herbert H. Dow Building Society of Women Engineers Careers / Jobs Herbert H. Dow Building
Novacoast, Inc. Corporate Information Session (September 19, 2018 6:00pm) https://events.umich.edu/event/54653 54653-13627529@events.umich.edu Event Begins: Wednesday, September 19, 2018 6:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Society of Women Engineers

Description:Description:Positions: Full-Time, Intern
Majors: All Engineering Majors
Degrees: Undergraduate
Citizenship: None
Resumes: Yes

Novacoast is a uniquely positioned professional services and solutions company built on broad offerings, deep expertise and a collaborative culture of adaptable problem solving. We are a comprehensive resource, offering everything from broader IT and security services to product development, staffing services to product fulfillment. Novacoast combines its advanced technical knowledge with our customers’ expertise so together we can make informed decisions and avoid costly IT mistakes.

*Food will be provided!
Contact: Society of Women Engineers (swe.cis-ind.publicity@umich.edu)

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Careers / Jobs Mon, 03 Sep 2018 12:29:52 -0400 2018-09-19T18:00:00-04:00 2018-09-19T19:30:00-04:00 Electrical Engineering and Computer Science Building Society of Women Engineers Careers / Jobs Electrical Engineering and Computer Science Building
Anheuser-Busch Corporate Information Session (September 19, 2018 6:30pm) https://events.umich.edu/event/55136 55136-13689425@events.umich.edu Event Begins: Wednesday, September 19, 2018 6:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Society of Women Engineers

Positions: Full-Time, Intern
Majors: All Engineering Majors
Degrees: Undergraduate
Citizenship: US Citizen
Resumes: No

*Food will be provided!
Contact: Society of Women Engineers (swe.cis-ind.publicity@umich.edu)

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Careers / Jobs Mon, 10 Sep 2018 14:59:43 -0400 2018-09-19T18:30:00-04:00 2018-09-19T20:00:00-04:00 Electrical Engineering and Computer Science Building Society of Women Engineers Careers / Jobs Electrical Engineering and Computer Science Building
A Bioethical Lunch in a "Moral Minute" (September 20, 2018 12:00pm) https://events.umich.edu/event/54447 54447-13585498@events.umich.edu Event Begins: Thursday, September 20, 2018 12:00pm
Location: North Campus Research Complex Building 18
Organized By: The Bioethics Discussion Group

A lunchtime discussion of the ethical implications of the (biomedical) work of current Ph.D students here at the University of Michigan.

Please RSVP here: https://docs.google.com/forms/d/e/1FAIpQLSeShJcc1nm5X6gCZMTZZdMDe7KBUKtcpEHBDdVTVoSa7NVH9A/viewform

For more information about the group in general, please check out our website: https://belmont.bme.umich.edu/bioethics-discussion-group/

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Lecture / Discussion Sat, 15 Sep 2018 11:15:04 -0400 2018-09-20T12:00:00-04:00 2018-09-20T13:30:00-04:00 North Campus Research Complex Building 18 The Bioethics Discussion Group Lecture / Discussion A moral minute
Nanoparticles Meet Biological Membranes: Probing Interaction Using Molecular Simulations (September 21, 2018 4:00pm) https://events.umich.edu/event/53428 53428-13381397@events.umich.edu Event Begins: Friday, September 21, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract:
Over the past decade, with advances in high-performance computing and data science, theory,
simulation, and computation continue to partner with experiment in discovery and innovation in
nanoscience and nanotechnology. Some of the most exciting applications are in the field of biomedicine. Indeed, a detailed understanding of the molecular details of interactions between nanoparticles and biological nanosystems, such as membranes or macromolecules is crucial for obtaining adequate information on mechanisms of action of nanomaterials as well as a perspective on the long-term effects of these materials and their possible toxicological outcomes. In this talk I will report on a new model that we are developing to understand and to predict the interactions between carbon-based nanomaterials and biological membranes using structure-based computational molecular modeling. A rationale on how nanoparticles of different sizes, shape, structure and chemical properties can affect the organization of cellular membranes is also presented. This critical information will help enable the “safe-by-design” production of engineered nanoparticles that are nontoxic or biocompatible, and also allow for the design of antimicrobial nanoparticles for environmental and biomedical applications.

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Workshop / Seminar Fri, 21 Sep 2018 10:31:41 -0400 2018-09-21T16:00:00-04:00 2018-09-21T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
The Enigmatic KIME: Time Complexity in Data Science (September 21, 2018 4:00pm) https://events.umich.edu/event/54407 54407-13581110@events.umich.edu Event Begins: Friday, September 21, 2018 4:00pm
Location: West Hall
Organized By: Michigan Institute for Data Science

Abstract: We will provide a constructive definition of “Big Biomedical/Health Data” and provide examples of the challenges, algorithms, processes, and tools necessary to manage, aggregate, harmonize, process, and interpret such data. In data science, time complexity frequently manifests as sampling incongruency, heterogeneous scales, and intricate dependencies. We will present the concept of 2D complex-time (kime) and illustrate how the kime-order (time) and kime-direction (phase) affect advanced predictive analytics and scientific inference based on Big Biomedical Data. Kime-representation solves the unidirectional arrows of time problems, e.g., psychological arrow of time reflects the irrevocable past to future flow and thermodynamic arrow of time reflecting the relentless growth of entropy. Albeit kime-phase angles may not always be directly observable, we will illustrate how they can be estimated and used to improve the resulting space-kime modeling, trend forecasting, and predictive data analytics. Simulated data, clinical observations (e.g., neurodegenerative disorders), and multisource census-like datasets (e.g., UK Biobank) will be used to demonstrate time-complexity and inferential-uncertainty.

Bio: Ivo D. Dinov is a professor of Health Behavior and Biological Sciences and Computational Medicine and Bioinformatics at the University of Michigan. He directs the Statistics Online Computational Resource, the Integrative Biostatistics and Informatics Core of the Michigan Nutrition and Obesity Research Center, and the Udall Parkinson’s Disease Biostatistics and Data Management Core. He co-directs the Center for Complexity and Self-management of Chronic Disease (CSCD Center) and the multi-institutional Probability Distributome Project. Dr. Dinov is an Associate Director for Education and Training of the Michigan Institute for Data Science (MIDAS). He is a member of the American Statistical Association (ASA), the International Association for Statistical Education (IASE), the American Medical Informatics Association (AMIA), and the American Association for the Advancement of Science (AAAS), as well as an Elected Member of the Institutional Statistical Institute (ISI).

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Workshop / Seminar Thu, 06 Sep 2018 09:51:17 -0400 2018-09-21T16:00:00-04:00 2018-09-21T17:00:00-04:00 West Hall Michigan Institute for Data Science Workshop / Seminar Ivo D. Dinov, Phd
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (September 24, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656658@events.umich.edu Event Begins: Monday, September 24, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-09-24T14:00:00-04:00 2018-09-24T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Reimagining Healthcare (September 24, 2018 5:30pm) https://events.umich.edu/event/55155 55155-13691646@events.umich.edu Event Begins: Monday, September 24, 2018 5:30pm
Location: University Hospitals
Organized By: NextGen Med

Monday, September 24th, 2018
5:30-7:00 PM
Ford Auditorium, University Hospital

Please join us as our panelists share their perspectives on the future of healthcare in the United States focusing on how the government, payers, and providers can interact to alleviate some of the key issues facing healthcare today.

This event is free, and we welcome all members of the University of Michigan community including students, faculty, and staff. Food will be served following the panel while supplies last.

Please RSVP at https://goo.gl/GbazVh

Please direct any additional questions to MedECGUMMS@gmail.com or NextGenMed@umich.edu or visit medecg.org/reimagining-healthcare for more information.

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Lecture / Discussion Mon, 10 Sep 2018 19:00:47 -0400 2018-09-24T17:30:00-04:00 2018-09-24T19:00:00-04:00 University Hospitals NextGen Med Lecture / Discussion
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (September 25, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656569@events.umich.edu Event Begins: Tuesday, September 25, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-09-25T14:00:00-04:00 2018-09-25T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Bioethics Discussion: Drugs (September 25, 2018 7:00pm) https://events.umich.edu/event/49421 49421-11453763@events.umich.edu Event Begins: Tuesday, September 25, 2018 7:00pm
Location: Lurie Biomedical Engineering
Organized By: The Bioethics Discussion Group

A roundtable discussion on the manipulation of our biochemical status.

Readings to consider:
"Towards responsible use of cognitive-enhancing drugs by the healthy"
"Adverse health effects of marijuana use"
"Practical, legal, and ethical issues in expanded access to investigational drugs"

For more information and/or to receive a copy of the readings, please contact Barry Belmont at belmont@umich.edu or visit https://belmont.bme.umich.edu/bioethics-discussion-group/discussions/017-drugs/.

Partake in the blog: https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Thu, 13 Sep 2018 17:53:37 -0400 2018-09-25T19:00:00-04:00 2018-09-25T20:30:00-04:00 Lurie Biomedical Engineering The Bioethics Discussion Group Lecture / Discussion Drugs
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (September 26, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656613@events.umich.edu Event Begins: Wednesday, September 26, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-09-26T14:00:00-04:00 2018-09-26T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
KPMG Corporate Information Session (September 26, 2018 6:00pm) https://events.umich.edu/event/55138 55138-13689427@events.umich.edu Event Begins: Wednesday, September 26, 2018 6:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Society of Women Engineers

Positions: Full-Time
Majors: All Engineering Majors
Degrees: Undergraduate, Masters, PhD
Citizenship: US Citizen
Resumes: Yes

Data & Analytics at KPMG

*Food will be provided!
Contact: Society of Women Engineers (swe.cis-ind.publicity@umich.edu)

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Careers / Jobs Mon, 10 Sep 2018 15:05:05 -0400 2018-09-26T18:00:00-04:00 2018-09-26T19:30:00-04:00 Electrical Engineering and Computer Science Building Society of Women Engineers Careers / Jobs Electrical Engineering and Computer Science Building
Sparrow Health System Corporate Information Session (September 26, 2018 6:00pm) https://events.umich.edu/event/55139 55139-13689428@events.umich.edu Event Begins: Wednesday, September 26, 2018 6:00pm
Location: Herbert H. Dow Building
Organized By: Society of Women Engineers

Positions: Full-Time, Intern
Majors: Biomedical Engineering, Chemical Engineering, Computer Engineering, Computer Science, Data Science, Industrial and Operations Engineering, Materials Science and Engineering, Mechanical Engineering
Degrees: Undergraduate, Masters
Citizenship: US Citizen or Permanent Resident
Resumes: Yes

Sparrow is mid-Michigan’s largest health system and its diverse range of facilities offer our community some of the most advanced medical technology in the world. By joining Sparrow, you join an organization that is committed to enhancing the services it provides to the region by establishing key partnerships with other outstanding institutions like the Mayo Clinic, Michigan State University, Mary Free Bed Rehabilitation Hospital, and Hayes Green Beach Memorial Hospital.

Sparrow’s mission is to improve the health of the people in our communities by providing quality, compassionate care to everyone, every time. The Sparrow IT and Analytics department supports the organization's vision by helping our Clinicians to leverage technology and data analytics in pursuit of better patient care and safety.

Serving a public purpose by providing excellent Patient care is at Sparrow’s core, and we hire the best in all the career fields that make for a highly successful organization, including information technology (IT). Sparrow IT offers a variety of challenging and fulfilling analytic, project management, IT training, and technical careers.

At Sparrow IT, we believe hiring people from a variety of educational and professional backgrounds makes for a stronger, more robust workforce. We welcome self-motivated people, who thrive in a highly collaborative environment, and want a career with real responsibility. Each day at Sparrow IT brings new opportunities and the chance to work as a team with Caregivers across the organization, including physicians, nurses, and other clinicians.

By joining the Sparrow IT team, you can grow professionally while doing meaningful work that serves a broader public purpose. Some of the applications you’ll get hands-on experience with include:
•EPIC Electronic Medical Record,
•Enterprise Resource Planning (ERP)
•Business intelligence/data analytics/data warehousing

If you are passionate about improving processes and systems in an industry that provides unmatched benefits to society, consider joining Sparrow IT and starting a rewarding career journey.

*Food will be provided!
Contact: Society of Women Engineers (swe.cis-ind.publicity@umich.edu)

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Careers / Jobs Mon, 10 Sep 2018 15:07:25 -0400 2018-09-26T18:00:00-04:00 2018-09-26T19:30:00-04:00 Herbert H. Dow Building Society of Women Engineers Careers / Jobs Herbert H. Dow Building
The Ross Effect (September 27, 2018 4:00pm) https://events.umich.edu/event/55018 55018-13665226@events.umich.edu Event Begins: Thursday, September 27, 2018 4:00pm
Location: Ross School of Business
Organized By: Ross One Year Graduate Programs

Employers look for the skills you’re developing in your undergraduate degree, like the ability to understand complex concepts and deliver creative solutions. But, connecting with companies and highlighting these skills is not always easy. Join us at "The Ross Effect" to learn how three outstanding Ross graduate programs, the Master of Accounting, the Master of Management and the Master of Supply Chain Management, will leverage your undergraduate training for a smooth and successful transition into the workforce.

This event is being held exclusively for non-Ross University of Michigan (Ann Arbor) students. The event is being held on the 5th floor of the Blau/Kresge side of the Ross Building, in the Blau Colloquium.

Questions? Email TheRossEffect@umich.edu

Register at:
https://www.eventbrite.com/e/the-ross-effect-how-a-ross-graduate-degree-amplifies-your-toolkit-registration-48421327494

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Presentation Fri, 07 Sep 2018 18:53:32 -0400 2018-09-27T16:00:00-04:00 2018-09-27T17:30:00-04:00 Ross School of Business Ross One Year Graduate Programs Presentation Michigan Ross Logo
Folded Viral RNAs that Sense and Manipulate the Host Cell Machinery: Windows to RNA Structure-Based Regulation (September 28, 2018 4:00pm) https://events.umich.edu/event/53429 53429-13381398@events.umich.edu Event Begins: Friday, September 28, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: RNA is perhaps the most functionally diverse biological macromolecule, due in large part to its ability to adopt a wide range of conformationally dynamic structures. The Kieft Lab is interested in understanding how RNA can adopt diverse three-dimensional folds, how those folds give rise to its many biological roles, and how conformational changes confer RNA’s ability to regulate so many processes. We are particularly interested in viral RNAs, which are fine-tuned by evolution to elegantly and powerfully interact with and manipulate the cellular machinery of the host cell; these viral RNAs provide a “window” into the greater RNA world. In this presentation, I will present some of our recent findings in regard to a viral RNA that adopts an unexpected tertiary structure. This RNA element undergoes programmed conformational changes that are triggered by its interactions with the host cell machinery and this is responsible for its unique function. This RNA may be a paradigm for novel modes of regulation linked to dynamic RNA conformational changes.

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Workshop / Seminar Wed, 26 Sep 2018 14:41:29 -0400 2018-09-28T16:00:00-04:00 2018-09-28T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Jeffrey Kieft
Donuts & Cider in the Duderstadt Connector (October 1, 2018 11:00am) https://events.umich.edu/event/56050 56050-13823410@events.umich.edu Event Begins: Monday, October 1, 2018 11:00am
Location: Chrysler Center
Organized By: Multidisciplinary Design Program

Stop by the Duderstadt Connector for Apple Cider & Washtenaw Dairy Donuts between 10 am and 2pm on Monday, October 1st.

Pick up a 2019 MDP Program Booklet, get tips for how to apply, and prepare for one of the major MDP recruitment events on 10/2 or 10/3.

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Exhibition Wed, 26 Sep 2018 13:10:22 -0400 2018-10-01T11:00:00-04:00 2018-10-01T14:00:00-04:00 Chrysler Center Multidisciplinary Design Program Exhibition Cider and Donuts
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (October 1, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656659@events.umich.edu Event Begins: Monday, October 1, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-10-01T14:00:00-04:00 2018-10-01T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
RNA Innovation Seminar | Theme: Computational analysis (October 1, 2018 3:00pm) https://events.umich.edu/event/55316 55316-13716052@events.umich.edu Event Begins: Monday, October 1, 2018 3:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Li Guan, PhD candidate
from the Laura Scott research group
“Human skeletal muscle eQTL meta-analysis reveals long-range genetic regulations”
&
Shiquan Sun, Ph.D.,
Postdoctoral fellow from the Zhou Lab
“Heritability estimation and differential analysis of count data with generalized linear mixed models in genomic sequencing studies”

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Lecture / Discussion Tue, 25 Sep 2018 08:52:23 -0400 2018-10-01T15:00:00-04:00 2018-10-01T16:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion seminar flyer
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (October 2, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656570@events.umich.edu Event Begins: Tuesday, October 2, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-10-02T14:00:00-04:00 2018-10-02T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
MDP 2019 Project Preview Night (October 2, 2018 6:00pm) https://events.umich.edu/event/56264 56264-13869403@events.umich.edu Event Begins: Tuesday, October 2, 2018 6:00pm
Location: BBB
Organized By: Multidisciplinary Design Program

Student Recruitment for 2019 MDP Teams Has Begun!

You will shake hands and speak with Faculty PIs and engineering and product development professionals about the MDP team they are sponsoring. Build your network, learn about the teams, and position yourself as a great candidate. Attire is casual!

What is the MDP Project Preview Night?

The 2019 MDP Project Preview Night will showcase 40+ teams with open positions for students across the University. All Corporate Partners and Faculty Research Teams will be in the BBB Building to meet with interested students, discuss design team opportunities, and collect student resumes. Attend this event if you cannot attend the Project Fair on Wednesday. Casual attire is expected.

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Careers / Jobs Mon, 01 Oct 2018 14:48:25 -0400 2018-10-02T18:00:00-04:00 2018-10-02T20:00:00-04:00 BBB Multidisciplinary Design Program Careers / Jobs BBB Atrium
Medicinal Chemistry & Pharmaceutical Sciences Open House (October 2, 2018 6:00pm) https://events.umich.edu/event/55689 55689-13768291@events.umich.edu Event Begins: Tuesday, October 2, 2018 6:00pm
Location: Palmer Commons
Organized By: U-M College of Pharmacy

Attention all Science, Pre-Health, and Engineering majors!

Are you interested in learning about graduate programs that will prepare you for an exciting career in drug discovery & drug development? If so, please make plans to attend the Medicinal Chemistry & Pharmaceutical Sciences Open House.

This event will feature a poster session where you can talk to graduate students and faculty members about their research. You will also have an opportunity to learn more about the benefits and requirements of the Medicinal Chemistry & Pharmaceutical Sciences PhD programs.

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Other Wed, 19 Sep 2018 16:03:49 -0400 2018-10-02T18:00:00-04:00 2018-10-02T20:30:00-04:00 Palmer Commons U-M College of Pharmacy Other
MDP 2019 Project Fair (October 3, 2018 12:00pm) https://events.umich.edu/event/56265 56265-13869404@events.umich.edu Event Begins: Wednesday, October 3, 2018 12:00pm
Location: Duderstadt Center
Organized By: Multidisciplinary Design Program

Student Recruitment for 2019 MDP Teams Has Begun!

You will shake hands and speak with Faculty PIs and engineering and product development professionals about the MDP team they are sponsoring. Build your network, learn about the teams, and position yourself as a great candidate. Attire is casual!

What is the MDP Project Fair?

The 2019 MDP Project Opportunity Fair will showcase 40+ teams with open positions for students across the University. All Corporate Partners and Faculty Research Teams will be in the Duderstadt Atrium to meet with interested students, discuss design team opportunities, and collect student resumes. Attend this event if you cannot attend the Project Preview Night on Tuesday. Casual attire is expected.

This event is very, very similar to the Project Preview night on 10/2 6-8pm in BBB….just in a different location, and the sponsors/faculty will have table displays with prototypes, screens, giveaways, etc. Attend either event – whichever fits your busy schedule.

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Careers / Jobs Mon, 01 Oct 2018 15:14:43 -0400 2018-10-03T12:00:00-04:00 2018-10-03T16:00:00-04:00 Duderstadt Center Multidisciplinary Design Program Careers / Jobs Duderstadt Connector
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (October 3, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656614@events.umich.edu Event Begins: Wednesday, October 3, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-10-03T14:00:00-04:00 2018-10-03T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
“Squish and Squeeze - Nuclear mechanics in physiology and disease” (October 4, 2018 9:00am) https://events.umich.edu/event/55506 55506-13750119@events.umich.edu Event Begins: Thursday, October 4, 2018 9:00am
Location: Chrysler Center
Organized By: Biomedical Engineering

The nucleus is the characteristic feature of eukaryotic cells and houses the genomic information of the cell. The Lammerding laboratory is combining cell and molecular biology approaches with tissue engineering and microfabrication techniques, live-cell microscopy, and in vivo models to investigate the interplay between nuclear structure, mechanics, and function. In particular, the research is addressing how physical forces acting on the nucleus, for example, in contracting muscle cells or during migration of cells through tight interstitial spaces, can challenge the integrity of the nucleus, alter its structure, and cause genomic and transcriptional changes. These processes play important roles in cellular mechanotransduction, i.e., the ability of cells to convert mechanical stimuli into biochemical signals, but can also contribute to various diseases when the nuclear structure is perturbed by mutations or altered protein expression. For example, mutations in the nuclear envelope proteins lamin A/C are responsible for a broad spectrum of diseases (laminopathies), including Emery-Dreifuss muscular dystrophy (EDMD) and dilated cardiomyopathy. The fact that most mutations result in highly tissue-specific disease phenotypes primarily affecting skeletal and cardiac muscles, in spite of the near ubiquitous expression of lamins A/C, suggest that lamin mutations may render cells more sensitive to mechanical stress, which then causes progressive cell failure in mechanically stressed tissues. I will discuss our recent findings that highlight the importance of lamins A/C in mediating nuclear stability and mechanotransduction in mechanically stressed cells and tissues. At the same time, increased nuclear deformability, caused for example by reduced levels of lamins A/C, can promote cell migration through tight spaces with cross-sections smaller than the nuclear diameter, where the large size and rigidity of the nucleus can constitute a rate-limiting factor. I will present recent findings that demonstrate the importance of nuclear mechanics during cell migration in confined environments in vitro and in vivo, as well as the functional consequences of cells having to squeeze their large nuclei through tight interstitial spaces and small pores in the extracellular matrix network, with a particular focus on breast cancer.

Jan Lammerding, Ph.D., is an Associate Professor in the Meinig School of Biomedical Engineering and the Weill Institute for Cell and Molecular Biology & Director of Graduate Studies at Cornell University.

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Lecture / Discussion Mon, 01 Oct 2018 14:13:09 -0400 2018-10-04T09:00:00-04:00 2018-10-04T10:00:00-04:00 Chrysler Center Biomedical Engineering Lecture / Discussion Biomedical Engineering
Duderstadt Center Fall Open House (October 5, 2018 12:00pm) https://events.umich.edu/event/55192 55192-13698256@events.umich.edu Event Begins: Friday, October 5, 2018 12:00pm
Location: Duderstadt Center
Organized By: Digital Media Commons

Join us Friday, October 5th (12-6pm)

The Duderstadt Center provides a nexus for creative and technological innovation across all disciplines.

Come see what new resources we are unveiling for the Fall semester, available to the entire University of Michigan community!

This is your first opportunity to experience the all new Visualization Studio, a powerful digital maker-space equipped with high end virtual reality development workstations, play areas and 3D modeling tools. Staffed by industry experts with a proven track record of successful augmented and virtual reality development in grants all across campus. Come experience the MIDEN, a 10'x10' immersive virtual reality room, and see how instructors and students are using VR as a platform to revolutionize teaching and learning.

Our recently unveiled Fabrication Studio is also available, equipped with an assortment of high end and self service 3D printers, laser cutters, electronic workbenches and a variety of hand tools. We will also soon be re-opening a freshly remodeled Design Studio come Winter - come see what will soon be a creative hub to suit all your artistic needs. Light tables, down shooters and a Hollywood mocap system for animation, large format scanners and photography tables, smart displays for iterative design and ideation, and various drafting/drawing tools.

Learn more at: http://www.dc.umich.edu/openhouse

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Community Service Wed, 12 Sep 2018 09:52:59 -0400 2018-10-05T12:00:00-04:00 2018-10-05T18:00:00-04:00 Duderstadt Center Digital Media Commons Community Service Duderstadt Center Open House
Seminar Title: "Functional approaches to understanding the development of the Small Multidrug Resistance family of transporters"- Chris Macdonald and "The effect of disruption of synaptic signaling on brain networks" - Maral Budak (October 5, 2018 4:00pm) https://events.umich.edu/event/53431 53431-13381399@events.umich.edu Event Begins: Friday, October 5, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract:
Chris Macdonald - The Small Multidrug Resistance (SMR) family of prokaryotic and archaean proton-coupled transporters provides a window into the evolutionary events that generated the molecular diversity of membrane protein function today. These small 4-pass integral membrane proteins assemble into functional dimers with an unusual antiparallel architecture. The most well-studied example, EmrE, is a homodimeric member that provides resistance to a broad range of hydrophobic cationic aromatic compounds. This talk will cover recent work in the Stockbridge lab that has fundamentally altered our understanding of this family, including functional characterization through flux measurements and solid-supported membrane (SSM) electrophysiology, in vivo metabolic assays, and phylogenetic analysis. We suggest an evolutionary trajectory for the development of new functions in these small proteins.

and

Maral Budak -The information transmission between neurons and brain regions occurs via synapses. Therefore, disruption of synaptic signaling (e.g. synaptic failure or desynchronization of spikes) may have devastating outcomes, such as loss of consciousness or neurodegenerative diseases. First, our objective is understanding the effect of synaptic failure on functional connectivity of different network structures, and we observed that synaptic failure does not always decrease the coherence of neuronal networks, but sometimes promotes the formation of coherent states of activity in the networks. Next, we aim to understand the mechanism of hidden hearing loss caused by myelinopathy. Recently, it’s been hypothesized that disruption of myelination patterns at auditory nerves (AN) causes desynchronization of AN spiking activity. To test this hypothesis, we constructed a reduced biophysical model for a population of inner hair cells with postsynaptic auditory nerve fibers. As a result, our model confirms that heminodal disruption causes desynchronization of AN spikes leading to a loss of temporal resolution.

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Workshop / Seminar Mon, 01 Oct 2018 11:59:37 -0400 2018-10-05T16:00:00-04:00 2018-10-05T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (October 8, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656660@events.umich.edu Event Begins: Monday, October 8, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-10-08T14:00:00-04:00 2018-10-08T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (October 9, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656571@events.umich.edu Event Begins: Tuesday, October 9, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-10-09T14:00:00-04:00 2018-10-09T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Bioethics Discussion: Alternative Medicine (October 9, 2018 7:00pm) https://events.umich.edu/event/49423 49423-11453765@events.umich.edu Event Begins: Tuesday, October 9, 2018 7:00pm
Location: Lurie Biomedical Engineering
Organized By: The Bioethics Discussion Group

A roundtable discussion at the boundaries of the medical sciences.

Readings to consider:
"The placebo effect in alternative medicine"
"The use of complementary and alternative medicine in pediatrics"
"Efficacy of complementary and alternative medicine therapies in relieving cancer pain: a systematic review"
"Trends in the use of complementary health approaches among adults: United States, 2002-2012"

For more information and/or to receive a copy of the readings, please contact Barry Belmont at belmont@umich.edu or visit https://belmont.bme.umich.edu/bioethics-discussion-group/discussions/018-alternative-medicine/.

Be mindful at the blog: https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Thu, 13 Sep 2018 17:54:30 -0400 2018-10-09T19:00:00-04:00 2018-10-09T20:30:00-04:00 Lurie Biomedical Engineering The Bioethics Discussion Group Lecture / Discussion Alternative medicine
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (October 10, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656615@events.umich.edu Event Begins: Wednesday, October 10, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-10-10T14:00:00-04:00 2018-10-10T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
"Engineering Therapies for Complex Diseases" (October 11, 2018 9:00am) https://events.umich.edu/event/55507 55507-13750120@events.umich.edu Event Begins: Thursday, October 11, 2018 9:00am
Location: Chrysler Center
Organized By: Biomedical Engineering

Many diseases lack a clear cause, making the search for therapies especially challenging. For example, there is no known cause for more than 80% of the cases of amyotrophic lateral sclerosis (ALS), and the remaining cases can be caused by mutations in any one of more than twenty genes. It is unlikely that any single therapeutic strategy will work for all these patients. We seek to understand such complex diseases better by gathering a wide variety of omic, clinical and behavior data. I’ll describe the approaches we are using to integrate these data, identify disease subtypes and explore their therapeutic potential.

Dr. Ernest Fraenkel is a professor in Biomedical Engineering at the Massachusetts Institute of Technology

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Lecture / Discussion Thu, 04 Oct 2018 14:09:38 -0400 2018-10-11T09:00:00-04:00 2018-10-11T10:00:00-04:00 Chrysler Center Biomedical Engineering Lecture / Discussion Biomedical Engineering
A Bioethical Lunch on Complementary Medicine (October 11, 2018 12:00pm) https://events.umich.edu/event/54449 54449-13585500@events.umich.edu Event Begins: Thursday, October 11, 2018 12:00pm
Location: North Campus Research Complex Building 18
Organized By: The Bioethics Discussion Group

A lunchtime discussion on how the "other kind" of medicine fits in.

Please RSVP by Tuesday, October 9th
https://goo.gl/forms/tzLNHHsHWBd0ojzj1

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Lecture / Discussion Fri, 28 Sep 2018 09:33:27 -0400 2018-10-11T12:00:00-04:00 2018-10-11T13:30:00-04:00 North Campus Research Complex Building 18 The Bioethics Discussion Group Lecture / Discussion Complementary medicine
Seminar Title: "Carbonaceous nanoparticle and biological membrane - a molecular dynamic perspective" (October 12, 2018 4:00pm) https://events.umich.edu/event/53433 53433-13381402@events.umich.edu Event Begins: Friday, October 12, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: Nanoparticles have been widely utilized in many health-related fields, such as drug delivery, cancer therapy, biolabeling, and biosensors. Studies on the molecular details of the interaction between nanoparticles and biological nanosystems are crucial for obtaining information on the mechanisms of the possible outcomes of these nanomaterials, such as cytotoxicity, biological accumulation, and long-term effects. In this talk, we will introduce a recent model that we are developing to help understand and predict the interaction between carbonaceous nanoparticles and biological membrane based on the molecular structural information. The model presents in detail how molecular properties of nanoparticles such as size, shape and chemical properties affect the organization of the nanoparticles in the membrane, as well how different components in the membrane affect the selectivity on nanoparticles. This critical information is helpful for designing engineered nanoparticles that are biocompatible, bioavailable for different environmental and biological applications.

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Workshop / Seminar Fri, 28 Sep 2018 11:27:26 -0400 2018-10-12T16:00:00-04:00 2018-10-12T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Desmond Liu
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (October 15, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656661@events.umich.edu Event Begins: Monday, October 15, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-10-15T14:00:00-04:00 2018-10-15T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (October 16, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656572@events.umich.edu Event Begins: Tuesday, October 16, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-10-16T14:00:00-04:00 2018-10-16T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (October 17, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656616@events.umich.edu Event Begins: Wednesday, October 17, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-10-17T14:00:00-04:00 2018-10-17T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Seminar Title: “Protons to patients: evaluating the role of the chloride transporter ClC-7 in lysosomal function” (October 19, 2018 4:00pm) https://events.umich.edu/event/53434 53434-13381403@events.umich.edu Event Begins: Friday, October 19, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: Lysosomes are essential focal points of cellular metabolism, digesting a wide range of macromolecules provided by endocytosis or autophagy. To this end, lysosomes rely on their highly acidic luminal pH to promote the function of their many enzymes, a pH generated by the action of a v-Type proton pumping ATPase. Since this transporter is electrogenic, parallel ion movements must occur to dissipate the generated membrane potential and promote bulk proton flux. I will present evidence that the Cl-/H+ antiporter, ClC-7, plays this role, moving Cl- to dissipate the lysosomal transmembrane voltage. However, the function of ClC-7 has been controversial, with conflicting reports on its contribution to lysosomal acidification. All heretofore known patients with ClC-7 functional mutations have varying degrees of the same disease, with osteopetrosis sometimes associated with lysosomal storage disease. Here, we report on two patients with a novel disease manifested as widespread lysosomal dysfunction but no bone abnormalities, who both have the same missense mutation in ClC-7. We find that fibroblasts from both patients have acidification abnormalities and that heterologously expressed human ClC-7 carrying this mutation displays a novel phenotype under electrophysiological measurements. These findings provide strong support for an important role of ClC-7 in the lysosomal acidification process and suggest opportunities for therapies for these patients.

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Workshop / Seminar Wed, 26 Sep 2018 15:30:54 -0400 2018-10-19T16:00:00-04:00 2018-10-19T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Joe Mindell
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (October 22, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656662@events.umich.edu Event Begins: Monday, October 22, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-10-22T14:00:00-04:00 2018-10-22T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (October 23, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656573@events.umich.edu Event Begins: Tuesday, October 23, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-10-23T14:00:00-04:00 2018-10-23T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Bioethics Discussion: Zombies (October 23, 2018 7:00pm) https://events.umich.edu/event/49424 49424-11453766@events.umich.edu Event Begins: Tuesday, October 23, 2018 7:00pm
Location: Lurie Biomedical Engineering
Organized By: The Bioethics Discussion Group

A roundtable discussion on the rights of the living, the dead, and those in between.

Readings to consider:
"Consciousness: the most critical moral (constitutional) standard for human personhood"
"CDC preparedness 101: zombie pandemic"
"Zombies v. materialists"
"In vitro meat"

For more information and/or to receive a copy of the readings, please contact Barry Belmont at belmont@umich.edu or visit https://belmont.bme.umich.edu/bioethics-discussion-group/discussions/019-zombies/.

Have your brain eaten by the blog: https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Thu, 13 Sep 2018 17:55:12 -0400 2018-10-23T19:00:00-04:00 2018-10-23T20:30:00-04:00 Lurie Biomedical Engineering The Bioethics Discussion Group Lecture / Discussion Zombies
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (October 24, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656617@events.umich.edu Event Begins: Wednesday, October 24, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-10-24T14:00:00-04:00 2018-10-24T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Praxair, Inc. Corporate Information Session (October 24, 2018 6:30pm) https://events.umich.edu/event/55145 55145-13689434@events.umich.edu Event Begins: Wednesday, October 24, 2018 6:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Society of Women Engineers

Positions: Full-Time, Intern
Majors: Aerospace Engineering, Biomedical Engineering, Chemical Engineering, Data Science, Electrical Engineering, Industrial and Operations Engineering, Materials Science and Engineering, Mechanical Engineering
Degrees: Masters, PhD
Citizenship: None
Resumes: Yes

Industrial Gases

*Food will be provided!
Contact: Society of Women Engineers (swe.cis-ind.publicity@umich.edu)

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Careers / Jobs Mon, 10 Sep 2018 15:20:06 -0400 2018-10-24T18:30:00-04:00 2018-10-24T20:00:00-04:00 Electrical Engineering and Computer Science Building Society of Women Engineers Careers / Jobs Electrical Engineering and Computer Science Building
2018 Massey TBI Regional Conference (October 25, 2018 8:30am) https://events.umich.edu/event/55950 55950-13811923@events.umich.edu Event Begins: Thursday, October 25, 2018 8:30am
Location: Junge Champions Center
Organized By: Michigan Center for Integrative Research in Critical Care (MCIRCC)

Supported by the Massey Foundation, the Massey TBI Regional Conference aims to improve the outcomes of those who suffer severe traumatic brain injuries by supporting technology development, and translational and clinical research that impacts the “golden hours” of care. Through lectures, a poster session, and scientific presentations from funded Massey TBI Grand Challenge teams, we will explore the diagnosis, monitoring, and treatment of this critical injury.
Learn more and register today at https://mcircc.umich.edu/events-training/regional-conference.

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Conference / Symposium Tue, 25 Sep 2018 08:42:26 -0400 2018-10-25T08:30:00-04:00 2018-10-25T16:30:00-04:00 Junge Champions Center Michigan Center for Integrative Research in Critical Care (MCIRCC) Conference / Symposium Massey TBI Regional Conference Header Image
Design for Global Health Academic Program Information Sessions (October 25, 2018 5:30pm) https://events.umich.edu/event/56788 56788-14003780@events.umich.edu Event Begins: Thursday, October 25, 2018 5:30pm
Location: GG Brown Laboratory
Organized By: Global Health Design Initiative

Students are invited to come learn about the Design for Global Health Academic Program! The UM Global Health Design Initiative (GHDI) application for the Design for Global Health Academic Program is open! This program consists of a summer fieldwork experience in Ghana or Ethiopia to inform a novel design project to be completed during Fall 2019. Participants will gain extensive design experience and exposure to healthcare practices in low-resource settings. This opportunity is open to engineering and non-engineering students with senior standing by Fall 2019.

To learn more about GHDI and to apply, visit https://globalhealthdesign.engin.umich.edu/. Please direct inquiries to globalhealthdesign@umich.edu.

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Careers / Jobs Wed, 17 Oct 2018 15:28:01 -0400 2018-10-25T17:30:00-04:00 2018-10-25T18:30:00-04:00 GG Brown Laboratory Global Health Design Initiative Careers / Jobs Global Health Design Initiative block M logo
Malaria Ecology and Epidemiology: Challenges to Interrupting Transmission (October 26, 2018 12:30pm) https://events.umich.edu/event/54035 54035-13515305@events.umich.edu Event Begins: Friday, October 26, 2018 12:30pm
Location: Public Health II
Organized By: MAC-EPID

Speakers include:
Kim Lindblade (World Health Organization)
Justin Cohen (Clinton Health Access Initiative)
Sharon Greene (New York City Department of Health and Mental Hygiene)

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Conference / Symposium Tue, 21 Aug 2018 18:19:36 -0400 2018-10-26T12:30:00-04:00 2018-10-26T17:30:00-04:00 Public Health II MAC-EPID Conference / Symposium Flyer
Engineering human tissues for regenerative medicine and study of disease (October 26, 2018 2:00pm) https://events.umich.edu/event/55746 55746-13777519@events.umich.edu Event Begins: Friday, October 26, 2018 2:00pm
Location: Gerald Ford Library
Organized By: Biomedical Engineering

Tissue engineering is becoming increasingly successful with authentically representing the actual environmental milieu of the development, regeneration and disease. The paradigm of tissue engineering is related to the integrated use of human cells, biomaterial scaffolds (structural and logistic templates for tissue formation) and bioreactors (culture systems providing environmental control, molecular and physical signaling) in regenerative medicine. Living human tissues can be bioengineered from the autologous stem cells, and tailored to the patient and the medical condition being treated. More recently, the same principles are being successfully applied to the patient-specific “organs on a chip” platforms designed to recapitulate some aspects of human physiology. This talk will discuss some recent advances in regenerative engineering and modeling of disease using functional human tissues grown in lab.

Gordana Vunjak-Novakovic is The Mikati Foundation Professor of Biomedical Engineering and Medical Sciences at Columbia University in the City of New York.

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Lecture / Discussion Mon, 24 Sep 2018 14:04:44 -0400 2018-10-26T14:00:00-04:00 2018-10-26T15:00:00-04:00 Gerald Ford Library Biomedical Engineering Lecture / Discussion Gordana Vunjak-Novakovic
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (October 29, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656663@events.umich.edu Event Begins: Monday, October 29, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-10-29T14:00:00-04:00 2018-10-29T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Design for Global Health Academic Program Information Sessions (October 29, 2018 6:00pm) https://events.umich.edu/event/56788 56788-14003781@events.umich.edu Event Begins: Monday, October 29, 2018 6:00pm
Location: Shapiro Library
Organized By: Global Health Design Initiative

Students are invited to come learn about the Design for Global Health Academic Program! The UM Global Health Design Initiative (GHDI) application for the Design for Global Health Academic Program is open! This program consists of a summer fieldwork experience in Ghana or Ethiopia to inform a novel design project to be completed during Fall 2019. Participants will gain extensive design experience and exposure to healthcare practices in low-resource settings. This opportunity is open to engineering and non-engineering students with senior standing by Fall 2019.

To learn more about GHDI and to apply, visit https://globalhealthdesign.engin.umich.edu/. Please direct inquiries to globalhealthdesign@umich.edu.

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Careers / Jobs Wed, 17 Oct 2018 15:28:01 -0400 2018-10-29T18:00:00-04:00 2018-10-29T19:00:00-04:00 Shapiro Library Global Health Design Initiative Careers / Jobs Global Health Design Initiative block M logo
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (October 30, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656574@events.umich.edu Event Begins: Tuesday, October 30, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-10-30T14:00:00-04:00 2018-10-30T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (October 31, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656618@events.umich.edu Event Begins: Wednesday, October 31, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-10-31T14:00:00-04:00 2018-10-31T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
"Resting-state fMRI connectivity and brain co-activations" (November 1, 2018 9:00am) https://events.umich.edu/event/55508 55508-13750121@events.umich.edu Event Begins: Thursday, November 1, 2018 9:00am
Location: Chrysler Center
Organized By: Biomedical Engineering

Resting-state functional Magnetic Resonance Image (rsfMRI) signal correlations are widely used for charting functional brain connectivity in healthy and diseased brains, and has revolutionized our understanding of the organization of large-scale brain networks and their abnormalities in various brain diseases. However, the neurophysiological basis underlying the images-based measures of brain connectivity/dynamics remains largely elusive. In this seminar, I describe multiple research projects that promoted the mechanistic understanding of the resting-state fMRI connectivity/dynamics. Combining multi-modal recordings from animals and humans under various brain conditions, these projects provide new insight into the dynamic nature of the resting-state connectivity, and reveal the electrophysiological correlates and behavioral relevance of global non-specific components of rsfMRI correlations.

Xiao Liu, Ph.D., is a professor in the department of Biomedical Engineering at Penn State University.

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Lecture / Discussion Mon, 29 Oct 2018 14:15:37 -0400 2018-11-01T09:00:00-04:00 2018-11-01T10:00:00-04:00 Chrysler Center Biomedical Engineering Lecture / Discussion Biomedical Engineering
Seminar Titles: "Quantitative analysis of the spindle assembly checkpoint (SAC)", Chu Chen and "Pattern Formation in 2D Tissues via Mechanics: From Juvenile Zebrafish to Human Embryonic Stem Cells", Hayden Nunley (November 2, 2018 4:00pm) https://events.umich.edu/event/53435 53435-13381404@events.umich.edu Event Begins: Friday, November 2, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstracts:
Chu Chen - In mammalian cells, accurate chromosome segregation during mitosis requires that kinetochores of sister chromatids attach to microtubules emanating from opposite spindle poles. In the absence of kinetochore-microtubule attachment, the spindle assembly checkpoint (SAC) is activated to delay anaphase onset. Over the past two decades, researchers have basically revealed the fundamental biochemical pathway of SAC signaling. However, how SAC effectively halts mitosis progression in the presence of very few unattached kinetochores is less addressed. In this talk, quantitative evidence will be presented which suggest the presence of synergistic actions in SAC. Hypothesis about the underlying mechanism and preliminary data from ongoing validation experiments will also be discussed. This cooperativity may enable a single unattached kinetochore to produce a strong enough signal.-

and

Hayden Nunley - Many epithelial tissues are composed of several types of cells with distinct functions. For proper functioning of the tissues, it is often important that the different types of cells form a spatial pattern. The specific biological details of how the cells interact to form these patterns are often not fully understood. To study the developmental processes in the absence of detailed biological information, it is useful to test which simplified physical models are consistent with experimental observations. With insights from these models, we identify specific candidate proteins or cellular structures necessary for the interaction, and generate predictions of how specific manipulations will affect tissue patterning. In this spirit, we will discuss the formation of a crystal of cone photoreceptors in juvenile zebrafish retinae. We find that the structure and arrangement of defects in the tissue are consistent with a purely mechanical model in which cones of one specific type interact with other cones of the same type at short range. We identify a specific cellular structure as a candidate for mediating this interaction. We will also discuss neural fate specification in human embryonic stem cell colonies. To study this pattern which has a length scale that does not scale with colony size, we propose a model in which cells respond to mechanical stresses by altering their contractility.

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Workshop / Seminar Tue, 16 Oct 2018 11:24:41 -0400 2018-11-02T16:00:00-04:00 2018-11-02T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab