Happening @ Michigan https://events.umich.edu/list/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. Biophysics Student Seminar (October 25, 2019 12:00pm) https://events.umich.edu/event/68668 68668-17130536@events.umich.edu Event Begins: Friday, October 25, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Shiyuan Wang - Yang Lab
Talk title: Understanding the Mitotic Oscillations with a Droplet-based System: How Does ATP Level Affect Oscillation Characteristics?

Ryan Hayes - Brooks Lab
Talk Title: Towards Protein Design with Rigorous Alchemical Calculation of
Folding Free Energies

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Workshop / Seminar Mon, 21 Oct 2019 15:42:14 -0400 2019-10-25T12:00:00-04:00 2019-10-25T13:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
Biophysics Talk Title: TBD (November 1, 2019 12:00pm) https://events.umich.edu/event/64274 64274-16274484@events.umich.edu Event Begins: Friday, November 1, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: TBD

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Workshop / Seminar Wed, 10 Jul 2019 09:39:20 -0400 2019-11-01T12:00:00-04:00 2019-11-01T13:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
Biophysics Talk Title: TBD (November 15, 2019 12:00pm) https://events.umich.edu/event/64282 64282-16274493@events.umich.edu Event Begins: Friday, November 15, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstracts: TBD

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Workshop / Seminar Wed, 10 Jul 2019 11:29:18 -0400 2019-11-15T12:00:00-05:00 2019-11-15T13:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
Biophysics Talk Title: TBD (November 22, 2019 12:00pm) https://events.umich.edu/event/64275 64275-16274485@events.umich.edu Event Begins: Friday, November 22, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: TBD

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Workshop / Seminar Wed, 10 Jul 2019 09:39:35 -0400 2019-11-22T12:00:00-05:00 2019-11-22T13:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
Being Human in STEM: An Experiment in Partnering with Students to Address Issues of Equity in STEM (January 16, 2020 12:00pm) https://events.umich.edu/event/69259 69259-17275351@events.umich.edu Event Begins: Thursday, January 16, 2020 12:00pm
Location: Rackham Graduate School (Horace H.)
Organized By: LSA Biophysics

When student protesters occupied the Amherst College library for four days in November of 2015, the campus community was transfixed by the painful testimonials shared by marginalized students about their experiences at Amherst as individuals identifying as Black, brown, female, queer, trans, disabled, international, among others. In response to letters from a Black neuroscience major and a non-binary biochemistry and biophysics major, every STEM department wrote a letter of support, pledging to work with students to address their concerns. The following semester, Chemistry professor Sheila Jaswal collaborated with students to develop a project-based course, titled “Being Human in STEM” (HSTEM), to actively engage STEM students and departments in learning about and enhancing inclusion in STEM settings. Now in its sixth iteration, students drive the academic inquiry, investigating both the local experience and the literature on diversity in STEM. They then use that research to design tools and interventions to share with and enhance their own STEM community.  In this seminar, Professor Jaswal will describe how HSTEM course projects and activities have continued the conversation started by students during the Uprising, connected STEM inclusion efforts across the Amherst campus, and produced resources such as the “Inclusive Curricular Practices” handbook, that have been used by STEM educators from high schools, colleges, universities, and the Howard Hughes Medical Institute Inclusive Excellence institutions. She will present evidence on the impact of the HSTEM course and practices on students, faculty and staff at Amherst, and provide examples of how a growing network of institutions, including Yale, Brown, Williams, and the University of Utah, are adapting the HSTEM model to their own STEM community needs. 

Please visit website for more information on speaker: http://www.beinghumaninstem.com/sheila-jaswal.html

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Workshop / Seminar Wed, 08 Jan 2020 12:58:03 -0500 2020-01-16T12:00:00-05:00 2020-01-16T14:00:00-05:00 Rackham Graduate School (Horace H.) LSA Biophysics Workshop / Seminar Rackham Graduate School (Horace H.)
Complex Systems/ICAM Symposium | "Emergence in Communication & Learning" (January 23, 2020 8:30am) https://events.umich.edu/event/70805 70805-17644330@events.umich.edu Event Begins: Thursday, January 23, 2020 8:30am
Location: Rackham Graduate School (Horace H.)
Organized By: The Center for the Study of Complex Systems

The Annual CSCS/ICAM Symposium 2020

Microbes, mice, and mockingbirds, economic markets and electronic machines all communicate but each does so in very different ways. This one-day symposium, sponsored by the University of Michigan's Center for the Study of Complex Systems in collaboration with the Institute for Complex Adaptive Matter, will bring together six leading researchers working across these diverse systems to investigate the emergence of communication and how it facilitates learning and language. The aim is to explore what makes these systems different and, importantly, what they have in common.

This symposium is free and open to the public. REGISTRATION is required for lunch.

Please Register at the link below. REGISTRATION CLOSES JAN. 20

SPEAKERS:

Josh Bongard, The University of Vermont, Computer Science
Jonathan Brennan, University of Michigan, Linguistics & Psychology
Erica Cartmill, UCLA, Anthropology
Stephen Diggle, Georgia Institute of Technology, Biological Sciences
Jacob Foster, UCLA, Sociology
Savithry Namboodiripad, University of Michigan, Linguistics

SCHEDULE

8:30 am Coffee & Light Breakfast

9:00 am Josh Bongard, The University of Vermont, Computer Science “word2vec2bot: Seeking body plans that facilitate language grounding in machines”

10:00 am Coffee Break

10:30 am Stephen Diggle, Georgia Institute of Technology, Biological Sciences “Cell-to-cell communication in bacteria”

11:30 am Erica Cartmill, UCLA, Anthropology "The Emergence of Form and Reference in Development and Evolution"

12:30 pm LUNCH (Registration Required)

1:30 pm Jonathan Brennan, University of Michigan, Linguistics & Psychology "Grammar in the brain"

2:30 pm Savithry Namboodiripad, University of Michigan, Linguistics “Language (contact) is whatever we want it to be: The role of top-down categorization in shaping emergent phenomena”

3:30 pm Coffee Break

4:00 pm Jacob Foster, UCLA, Sociology "Beyond Babel? Context, Convergence, and the Prospects for Universal Communication"

This symposium is free and open to the public. REGISTRATION is required for lunch.

Please Register at the link below. REGISTRATION WILL CLOSE JAN. 20

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Conference / Symposium Tue, 21 Jan 2020 12:34:55 -0500 2020-01-23T08:30:00-05:00 2020-01-23T17:00:00-05:00 Rackham Graduate School (Horace H.) The Center for the Study of Complex Systems Conference / Symposium CSCS/ICAM PRESENT
Annual Symposium in Biophysics (March 13, 2020 8:00am) https://events.umich.edu/event/69839 69839-17472589@events.umich.edu Event Begins: Friday, March 13, 2020 8:00am
Location: Michigan Union
Organized By: LSA Biophysics

TBD

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Conference / Symposium Mon, 02 Dec 2019 08:43:25 -0500 2020-03-13T08:00:00-04:00 2020-03-13T17:00:00-04:00 Michigan Union LSA Biophysics Conference / Symposium Michigan Union
Biophysics- Talk Title: TBD (March 27, 2020 12:00pm) https://events.umich.edu/event/64276 64276-16274486@events.umich.edu Event Begins: Friday, March 27, 2020 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: TBD

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Workshop / Seminar Wed, 10 Jul 2019 09:39:47 -0400 2020-03-27T12:00:00-04:00 2020-03-27T13:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
Biophysics Talk Title: TBD (April 3, 2020 12:00pm) https://events.umich.edu/event/64277 64277-16274487@events.umich.edu Event Begins: Friday, April 3, 2020 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: TBD

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Workshop / Seminar Wed, 10 Jul 2019 09:41:12 -0400 2020-04-03T12:00:00-04:00 2020-04-03T13:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
Biophysics Talk Title: TBD (April 17, 2020 12:00pm) https://events.umich.edu/event/64278 64278-16274488@events.umich.edu Event Begins: Friday, April 17, 2020 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: TBD

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Workshop / Seminar Wed, 10 Jul 2019 09:42:41 -0400 2020-04-17T12:00:00-04:00 2020-04-17T13:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
Data Science, Time Complexity, and Spacekime Analytics (September 11, 2020 12:00pm) https://events.umich.edu/event/76500 76500-19719162@events.umich.edu Event Begins: Friday, September 11, 2020 12:00pm
Location: Off Campus Location
Organized By: LSA Biophysics

Digital information flows impact all human experiences. The proliferation of large, heterogeneous, and spatio-temporal data requires novel approaches for managing, modeling, analyzing, interpreting, and visualizing complex information. The scientific community is developing, validating, productizing, and supporting novel mathematical techniques, advanced statistical computing algorithms, transdisciplinary tools, and effective artificial intelligence apps.

Spacekime analytics is a new technique for modeling high-dimensional longitudinal data. This approach relies on extending the notions of time, events, particles, and wavefunctions to complex-time (kime), complex-events (kevents), data, and inference-functions. We will illustrate how the kime-magnitude (longitudinal time order) and kime-direction (phase) affect the subsequent predictive analytics and the induced scientific inference. The mathematical foundation of spacekime calculus reveals interesting statistical implications including inferential uncertainty and a Bayesian formulation of spacekime analytics. Complexifying time allows the lifting of all commonly observed processes (e.g., time-series) from the classical 4D Minkowski spacetime to a 5D spacekime manifold (e.g., kime-surfaces), where a number of mathematical problems remain to be solved.

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Livestream / Virtual Tue, 01 Sep 2020 14:53:10 -0400 2020-09-11T12:00:00-04:00 2020-09-11T13:00:00-04:00 Off Campus Location LSA Biophysics Livestream / Virtual Ivo D. Dinov
Biophysics Virtual Seminar Series (September 18, 2020 12:00pm) https://events.umich.edu/event/76959 76959-19780559@events.umich.edu Event Begins: Friday, September 18, 2020 12:00pm
Location: Off Campus Location
Organized By: LSA Biophysics

*Please see below for the link to join the Zoom livestream*

The Biophysics Virtual Seminar Series Presents:

Zhenyu Tan - Biophysics Ph.D. Candidate (Cianfrocco Group)

The mitochondrial cargo adaptor TRAK1 has overlapping binding sites for kinesin-1 and dynein

Abstract: Positioning of axonal mitochondria into target locations is critical for the physiology of neurons as they supply energy and calcium buffering capacity. The outer mitochondrial membrane protein Miro cooperates with TRAK1 and TRAK2 to scaffold kinesin and dynein, driving anterograde and retrograde mitochondrial transport. To understand how TRAK1 regulates both kinesin and dynein, we utilized biochemical reconstitution to define the minimal region of TRAK1 sufficient for promoting motor activation. We characterized that TRAK1 has overlapping binding sites for kinesin-1 and dynein that is capable of activating both motors *in vitro*.

Thomas Paul - Postdoctoral Researcher (Brooks Group)

pH Dependent Dissociation of Folate from Folic Acid Receptors

Abstract: The pH dependent binding and release of folate from folic acid receptors (FRs) is not well understood. Therefore, we have studied pKa shifts for two isoforms of FRs (FOLR1 and FOLR2) in their apo and holo forms using explicit solvent constant pH molecular dynamics (CPHMD^MSλD). Our key findings highlight amino acid residues that have upward pKa shifts that contribute significantly to destabilizing the FRs:folate complex at pH values consistent with an endosomal environment which allows us to propose a potential mechanism of release.

Zoom passcode: 677763

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Livestream / Virtual Wed, 16 Sep 2020 10:45:33 -0400 2020-09-18T12:00:00-04:00 2020-09-18T13:00:00-04:00 Off Campus Location LSA Biophysics Livestream / Virtual Zhenyu Tan, PhD Candidate and Thomas Paul, Researcher
Biophysics Virtual Seminar Series (October 2, 2020 12:00pm) https://events.umich.edu/event/77871 77871-19939555@events.umich.edu Event Begins: Friday, October 2, 2020 12:00pm
Location: Off Campus Location
Organized By: LSA Biophysics

*Please see below for link to join the Zoom event. Passcode: Biophysics*

The Biophysics Virtual Seminar Series Presents:

Nirupama Sumangala - Biophysics Ph.D. Candidate (Ramamoorthy Group)

"Lipid Membrane Plays an Important Role for Facilitating Electron Transfer in Cytochrome P450"

Abstract: Cytochrome P450s (CYP450s) are a ubiquitous superfamily of enzymes that play a vital role in the metabolism of many exogenous and endogenous substrates including over 70% of the drugs on the market. For the catalytic reaction, CYP450 requires two electrons to be subsequently delivered, with the first one coming from cytochrome P450 reductase (CPR) and the second one from either CPR or cytochrome b5 (cytb5). We are interested in understanding the role of membrane in mediating the electron transfer from redox partners to CYP450. Our findings reveal that the lipid membrane is crucial to mediate a productive CYP450-CPR complex for electron transfer. Our data emphasizes the importance of studying the structure, dynamics and kinetics of CYP450 metabolon in a biologically relevant membrane mimetic system.

Keanu Guardiola Flores - Biophysics Ph.D. Candidate (Wood Group)

"Drug Effects on *Enterococcus Faecalis* Biofilms: Growth, Topology, and Population Dynamics"

Abstract: The emergence of antibiotic resistance poses a growing threat to public health and increasingly limits our ability to treat and control infections. Recently, researchers have shifted their focus to length scales where ecological and evolutionary dynamics of bacterial communities highlight new approaches for slowing resistance with currently available drugs. By combining confocal microscopy with simple mathematical models I will show how antibiotics shape the composition of biofilms as well as their spatial architecture at the single-cell level. Our results suggest that in spatially structured populations, which may more accurately reflect natural bacterial communities, the selection of resistance is not a simple result of homogenous selections but depends critically on the spatial arrangement of cells.

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Livestream / Virtual Tue, 29 Sep 2020 08:47:28 -0400 2020-10-02T12:00:00-04:00 2020-10-02T13:00:00-04:00 Off Campus Location LSA Biophysics Livestream / Virtual
Biophysics Virtual Seminar Series (October 9, 2020 12:00pm) https://events.umich.edu/event/76961 76961-19782523@events.umich.edu Event Begins: Friday, October 9, 2020 12:00pm
Location: Off Campus Location
Organized By: LSA Biophysics

*Please see below for the link to join the Zoom livestream*

The Biophysics Virtual Seminar Series Presents:

Hong Qian - Olga Jung Wan Endowed Professor of Applied Mathematics, Department of Applied Mathematics, University of Washington

“A Mathematical Principle of Stochastic Chemical Kinetics and
Emergent Chemical Thermodynamics that Applies to Living Cells”

Abstract: In contrast to featureless point masses in Mechanics, a macromolecule in biochemistry has a large number of internal degrees of freedom in terms of atoms. The behavior of even a single protein in an aqueous environment, is often so complex that the mathematical representation of biochemical kinetics has to be statistical. In this talk, I present a stochastic formulation of general chemical reaction systems, with *N* species and *M* stochastic elementary reactions in solution and show how J. W. Gibbs’ macroscopic equilibrium chemical thermodynamics can be derived as a mathematical result, with an entropic force as its center piece. Our theory is actually applicable to mesoscopic open chemical systems with a chemostat, such as a single living cell. I then discuss the application of this theory to understand the notion of non-genetic phenotype switching, in terms of a landscape, in cell differentiation and cancer heterogeneity.

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Livestream / Virtual Fri, 09 Oct 2020 10:27:08 -0400 2020-10-09T12:00:00-04:00 2020-10-09T13:00:00-04:00 Off Campus Location LSA Biophysics Livestream / Virtual Zoom Passcode: Biophysics
Biophysics Seminar Series (October 16, 2020 12:00pm) https://events.umich.edu/event/77916 77916-19941582@events.umich.edu Event Begins: Friday, October 16, 2020 12:00pm
Location: Off Campus Location
Organized By: LSA Biophysics

*Please see below for the link to join the Zoom event.*

The Biophysics Virtual Seminar Series presents:

Dr. Jamie Cate - Professor of Molecular & Cell Biology, and Chemistry,
University of California - Berkeley

“Selective modulation of human translation: potential for new therapeutics”

ABSTRACT: Small molecules that target the ribosome such as antibiotics generally impact a substantial fraction of the proteome. We recently identified a class of small molecules that bind the human ribosome and selectively stall the translation of a small subset of proteins. I will present biochemical and cell-based experiments, along with structures of human ribosome nascent chain complexes (RNCs) stalled by these compounds, determined by cryo-electron microscopy (cryo-EM). These small molecules bind in the ribosome exit tunnel in a eukaryotic-specific pocket formed by the 28S ribosomal RNA (rRNA) and arrest the translating ribosome through their interactions with the growing polypeptide chain. Intriguingly, a given compound can either inhibit or enhance translation, depending on the sequence of the protein nascent chain. These results begin to reveal how small molecules can be made to control human translation and suggest a new strategy for developing small molecules that selectively inhibit or enhance the production of proteins previously considered “undruggable.”

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Livestream / Virtual Thu, 08 Oct 2020 12:47:14 -0400 2020-10-16T12:00:00-04:00 2020-10-16T13:00:00-04:00 Off Campus Location LSA Biophysics Livestream / Virtual Dr. Jamie Cate
Biophysics Seminar Series (October 23, 2020 12:00pm) https://events.umich.edu/event/77918 77918-19941583@events.umich.edu Event Begins: Friday, October 23, 2020 12:00pm
Location: Off Campus Location
Organized By: LSA Biophysics

*Please see below for the link to join the Zoom event.*

The Biophysics Virtual Seminar Series presents:

Dr. Sandra Schmid - Chief Scientific Officer, Chan Zuckerberg Biohub

“Dynamin: A catalyst for fission, collaboration and controversy”

ABSTRACT: Kazuo Ikeda’s beautiful electron micrographs of neuromuscular junctions of Drosophila *shibire* mutants revealed the presence of collar-like structures around the necks of trapped endocytic intermediates. They inspired my 30 year-long obsession with dynamin, the mammalian homologue of *shibire.* Our subsequent studies of dynamin, which began in the early 90s provide benefitted from the development of new technologies and from interdisciplinary collaboration. I’ll describe the twists and turns of our efforts to understand the mechanisms underlying dynamin-catalyzed fission, the value of interdisciplinary collaborations, and the importance of taking all data into account when formulating models. I’ll detail our current understanding of dynamin-catalyzed fission, now supported by independent studies of others, and briefly describe the many remaining unanswered questions, keeping in mind (in the words of George Box) that, *“All models are wrong, but some are useful."*

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Livestream / Virtual Mon, 19 Oct 2020 15:12:59 -0400 2020-10-23T12:00:00-04:00 2020-10-23T13:00:00-04:00 Off Campus Location LSA Biophysics Livestream / Virtual Dr. Sandra Schmid