Happening @ Michigan https://events.umich.edu/list/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. Movement on Demand: Pharmacological and Protein-based Inhibition of Mitotic Kinesins (March 11, 2022 2:00pm) https://events.umich.edu/event/92880 92880-21697632@events.umich.edu Event Begins: Friday, March 11, 2022 2:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

We are pleased to announce that April Solon will present her Dissertation Defense on March 11, 2022, in person at Kahn Auditorium (BSRB) and via live stream on Friday, March 11th at 2:00 pm!

April will present: Movement on Demand: Pharmacological and Protein-based Inhibition of Mitotic Kinesins

Livestream: https://umich.zoom.us/j/98859460380 Passcode: April

Hosted By the Dissertation Committee:
Professor: Nouri Neamati, Chair
Associate: Professor Puck Ohi, Mentor
Professor: Kristen Verhey
Professor: Howard Crawford

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Lecture / Discussion Wed, 02 Mar 2022 12:20:16 -0500 2022-03-11T14:00:00-05:00 2022-03-11T15:00:00-05:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion Movement on Demand: Pharmacological and Protein-based Inhibition of Mitotic Kinesins
BioArtography - Call for Images (March 12, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701903@events.umich.edu Event Begins: Saturday, March 12, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-12T00:00:00-05:00 2022-03-12T23:59:00-05:00 BioArtography Other U-M BioArtography
BioArtography - Call for Images (March 13, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701904@events.umich.edu Event Begins: Sunday, March 13, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-13T00:00:00-05:00 2022-03-13T23:59:00-04:00 BioArtography Other U-M BioArtography
BioArtography - Call for Images (March 14, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701905@events.umich.edu Event Begins: Monday, March 14, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-14T00:00:00-04:00 2022-03-14T23:59:00-04:00 BioArtography Other U-M BioArtography
BIBC Neurosurgery Faculty Candidate (March 14, 2022 11:00am) https://events.umich.edu/event/92827 92827-21697073@events.umich.edu Event Begins: Monday, March 14, 2022 11:00am
Location: Medical Science Unit II
Organized By: BioInnovations in Brain Cancer

This Research Seminar is for the BioInnovations in Brain Cancer Tenure Track Faculty Search.

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Conference / Symposium Mon, 28 Feb 2022 11:09:22 -0500 2022-03-14T11:00:00-04:00 2022-03-14T12:00:00-04:00 Medical Science Unit II BioInnovations in Brain Cancer Conference / Symposium Dr. Christof Fellmann - Research Seminar Flyer
MCDB Connell Lecture > Thomas C. Südhof, M.D. (March 14, 2022 3:00pm) https://events.umich.edu/event/90404 90404-21670709@events.umich.edu Event Begins: Monday, March 14, 2022 3:00pm
Location: Rackham Graduate School (Horace H.)
Organized By: Department of Molecular, Cellular, and Developmental Biology

Thomas C. Südhof is a Nobel-prize winning biochemist at Stanford University.

The Südhof laboratory studies how synapses form in the brain and how their properties are specified, which together organize neural circuits. Moreover, the Südhof laboratory examines how synapses become dysfunctional in neurodegenerative and neuropsychiatric disorders to pave the way for better therapies.

Dr. Südhof has had a remarkably productive career studying the molecular mechanisms controlling synaptic transmission and synaptogenesis. He is perhaps best known for his work identifying the core molecular machinery controlling the fusion of synaptic vesicles with the plasma membrane, including the calcium sensor synaptotagmin. His group also discovered neurexins and neuroligins, which are important cell-surface proteins controlling the specificity synapse formation.

In recent years, his group and collaborators have explored the molecular basis of several human diseases, including Alzheimer’s disease, schizophrenia and autism.

Dr. Südhof has been an HHMI Investigator since 1986 and is the recipient of many awards recognizing his fundamental contributions to neuroscience and cell/molecular biology--among them, induction into the National Academy of Sciences (2002), the Kavli Prize (2010), the Albert Lasker Award (2013) as well as the 2013 Nobel Prize in Physiology.

After Dr. Südhof’s seminar there will be a reception in the West Atrium of the Biological Sciences Building under the life-size model of a pterosaur (Quetzalcoatlus northropi, the largest known flying animal to ever live on earth).

Please join us on March 14 for what will no doubt be a fascinating talk and an opportunity to meet with Dr. Südhof and members of the U-M science community.


Connell Lecture
This special event is possible through an endowment from Priscilla Connell's family as a memorial to her career as a nature photographer.

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Lecture / Discussion Mon, 28 Feb 2022 15:12:33 -0500 2022-03-14T15:00:00-04:00 2022-03-14T16:30:00-04:00 Rackham Graduate School (Horace H.) Department of Molecular, Cellular, and Developmental Biology Lecture / Discussion Portrait of Thomas Südhof
BioArtography - Call for Images (March 15, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701906@events.umich.edu Event Begins: Tuesday, March 15, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-15T00:00:00-04:00 2022-03-15T23:59:00-04:00 BioArtography Other U-M BioArtography
Integrating intersectionality into Environmental Health Sciences (March 15, 2022 12:00pm) https://events.umich.edu/event/92997 92997-21698985@events.umich.edu Event Begins: Tuesday, March 15, 2022 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

*Registered required.

Ami Zota, ScD, MS, is an Associate Professor in the Department of Environmental & Occupational Health at George Washington University's Milken School of Public Health. Dr. Zota’s work seeks to secure environmental justice and improve health equity through advancements in science, policy, and clinical practice. Her research identifies novel pathways linking social disparities, environmental exposures, and reproductive and children’s health.

The environmental research seminar series is organized by the Integrated Health Sciences Core of the Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD). More information about M-LEEaD and upcoming events can be found here: http://mleead.umich.edu/index.php

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Lecture / Discussion Fri, 04 Mar 2022 09:34:10 -0500 2022-03-15T12:00:00-04:00 2022-03-15T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Integrating intersectionality into Environmental Health Sciences
“Mechanobiology of vertebrate gut morphogenesis" (March 15, 2022 4:00pm) https://events.umich.edu/event/92788 92788-21695466@events.umich.edu Event Begins: Tuesday, March 15, 2022 4:00pm
Location: Off Campus Location
Organized By: Center for Cell Plasticity and Organ Design

The Center for Cell Plasticity and Organ Design is proud to present the following seminar with guest speaker Nandan L. Nerurkar, PhD, Assistant Professor of Biomedical Engineering at Columbia University.

The talk is entitled, "Mechanobiology of vertebrate gut morphogenesis."

Faculty Host: Brendon Baker, PhD, Biomedical Engineering

For more information, please email Organogenesis@umich.edu

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Lecture / Discussion Thu, 24 Feb 2022 21:22:04 -0500 2022-03-15T16:00:00-04:00 2022-03-15T17:00:00-04:00 Off Campus Location Center for Cell Plasticity and Organ Design Lecture / Discussion Nerurkar Flyer
Establishing Compositional Control in 2D and 3D Metal Sulfide Electrocatalysts to Drive CO2 and CO Conversion to Alcohols (March 15, 2022 4:00pm) https://events.umich.edu/event/84371 84371-21623617@events.umich.edu Event Begins: Tuesday, March 15, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Development of materials that address the growing dichotomy of simultaneously increasing energy demands and carbon emissions is an imperative that has progressively affected energy-related research efforts. An emerging technical avenue in this area is the conversion of vastly abundant renewable energy sources that can be harnessed and directed towards synthesis of traditionally fossil fuel-based products from atmospheric feedstocks like CO2. To this end, our work establishes structure—function relationships for materials within the versatile classes of MX2 (M = Mo, W; X = S, Se) and Chevrel-Phase (CP) MyMo6X8 (M = alkali, alkaline, transition or post-transition metal; y = 0-4; X = S, Se, Te) chalcogenides. The molybdenum sulfide structures from both families exhibit exceptional promise as CO2R catalysts. Furthermore, we have identified the CP catalyst framework as being selective towards the electrochemical reduction of CO2 and CO to methanol (only major liquid-phase product) under applied potentials as mild as -0.4 V vs RHE. Reactivity toward electrochemical reduction of CO2 and CO to methanol is correlated with increased population of chalcogen states, as confirmed via X-Ray Absorption Spectroscopy. Overall, this work seeks to unravel optimally reactive novel small-molecule reduction catalyst compositions.
Jesus Velazquez (University of California, Davis)

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Other Tue, 15 Mar 2022 18:15:27 -0400 2022-03-15T16:00:00-04:00 2022-03-15T17:15:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Functional MRI 2021-22 Speaker Series with Kawin Setsompop, Ph.D. (March 15, 2022 4:00pm) https://events.umich.edu/event/92833 92833-21697181@events.umich.edu Event Begins: Tuesday, March 15, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Functional MRI Lab

Abstract:

Advances in MRI’s instrumentation, data acquisition, and reconstruction algorithms have opened up exciting opportunities for dramatic gains in MR image encoding efficiency, particularly through the use of continuous volumetric data acquisition strategies. In this talk, I will provide an overview of the on-going research in my lab in developing technologies in this direction. The goal of our work has been in moving towards more precise MR imaging, or ‘precision MRI’, where the targets have been in achieving: i) rapid and comprehensive, high-resolution brain exam with a wealth of precise quantitative tissue parameters and multi-tissue compartment information, and ii) high-speed mesoscale structural and functional imaging of the brain, where the imaging can be done precisely, free of the typical distortion and blurring artifacts that have plagued standard EPI and spiral acquisitions.

You can attend in person: 4 p.m. Chemistry & Dow Willard H Laboratory (Central Campus), Room 1300.

You can attend via Zoom: https://umich.zoom.us/j/96633733558, passcode: 721418

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Lecture / Discussion Mon, 28 Feb 2022 13:18:26 -0500 2022-03-15T16:00:00-04:00 2022-03-15T17:30:00-04:00 Chemistry Dow Lab Functional MRI Lab Lecture / Discussion Kawin Setsompop, Ph.D.
BioArtography - Call for Images (March 16, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701907@events.umich.edu Event Begins: Wednesday, March 16, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-16T00:00:00-04:00 2022-03-16T23:59:00-04:00 BioArtography Other U-M BioArtography
MCDB Defense> Mechanisms of Lysosome Biogenesis and Regulation (March 16, 2022 1:30pm) https://events.umich.edu/event/93110 93110-21700730@events.umich.edu Event Begins: Wednesday, March 16, 2022 1:30pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Mentor: Ming Li

Hybrid event

Link and Passcode in the Weekly Update or
email: mcdb.seminar.info@umich.edu

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Workshop / Seminar Tue, 08 Mar 2022 10:30:40 -0500 2022-03-16T13:30:00-04:00 2022-03-16T14:30:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow initials MCDB and cartoon of a microscope on a blue background
BioArtography - Call for Images (March 17, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701908@events.umich.edu Event Begins: Thursday, March 17, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-17T00:00:00-04:00 2022-03-17T23:59:00-04:00 BioArtography Other U-M BioArtography
“The Salivary Glands: Robust Sites for Infection and Transmission of SARS-CoV-2” (March 17, 2022 12:00pm) https://events.umich.edu/event/92751 92751-21695193@events.umich.edu Event Begins: Thursday, March 17, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

BIOGRAPHY
Born: August 3rd, 1981, Defiance, Ohio, United States of America

LICENSES & CERTIFICATIONS
Diplomate, Oral and Maxillofacial Pathology – American Board of Oral and Maxillofacial Pathology
Dental License(s) – Unrestricted Dental License, Commonwealth of Pennsylvania, DS039850
DEA Registration – US Department of Justice
CPR Certification – American Red Cross

HONORS, AWARDS, & NOTEWORTHY INVITED TALKS.
2021 American College of Rheumatology Convergence, Invited Speaker, “Epigenetics of Sjogren’s Syndrome.” November 2021. >600 Attendees/Views.

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Lecture / Discussion Tue, 01 Mar 2022 11:08:51 -0500 2022-03-17T12:00:00-04:00 2022-03-17T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Lecture / Discussion Blake Warner, DDS, PhD, MPH Assistant Clinical Investigator Chief of the Salivary Disorders Unit and the Sjogren’s Syndrome Clinic NIH National Institute of Dental and Craniofacial Research
DCM&B Tools and Technology Seminar (March 17, 2022 12:00pm) https://events.umich.edu/event/89810 89810-21665888@events.umich.edu Event Begins: Thursday, March 17, 2022 12:00pm
Location: Off Campus Location
Organized By: DCMB Tools and Technology Seminar

This presentation will be remote only via Zoom

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Presentation Mon, 07 Mar 2022 13:13:54 -0500 2022-03-17T12:00:00-04:00 2022-03-17T13:00:00-04:00 Off Campus Location DCMB Tools and Technology Seminar Presentation
LSI Seminar Series: William C. Mobley, M.D., Ph.D., University of California, San Diego (March 17, 2022 12:00pm) https://events.umich.edu/event/92761 92761-21695328@events.umich.edu Event Begins: Thursday, March 17, 2022 12:00pm
Location: Palmer Commons
Organized By: Life Sciences Institute (LSI)

Synapse dysfunction and loss are hallmarks of Alzheimer’s disease (AD), responsible for its clinical manifestations. Defining the molecular basis for deficits in synapse structure and function are essential for elucidating AD pathogenesis and promise to enhance discovery of effective treatments. Elderly adults with Down syndrome (DS) demonstrate many of the clinical and pathological manifestations of AD; the condition is referred to as AD-DS. While age is an important risk factor for both AD and AD-DS, how age intersects with underlying changes in brain function are unclear. Studies in DS provide an opportunity to decipher the biology that underlies the impact of age on the genetic factor known to be necessary for AD-DS, an increase in APP copy number. Studies of synapse dysfunction and loss are not well investigated in those with AD-DS. We will explore the age by gene interaction through cell biological and in vivo studies in a mouse model and in the AD-DS brain.


**About the Speaker**
William Mobley is a Distinguished Professor of Neurosciences and Associate Dean for Neurosciences Initiatives at the University of California, San Diego. He came to UCSD in June of 2009 from Stanford University, where he served as the John E. Cahill Family Professor in the Department of Neurology and Neurological Sciences and was the founding director of the Neuroscience Institute. He earned his Ph.D. in neuro- & behavioral science from Stanford University in Palo Alto, California in 1974 and an M.D. from the same institution in 1976. Dr. Mobley completed an internship in pathology in 1977 and a pediatric residency in 1979, both at Stanford University, followed by a residency and fellowship in Neurology and Pediatric Neurology at The Johns Hopkins University. While there, he was selected to serve as chief resident in pediatric neurology from 1981 to 1982. He is certified by both the American Board of Pediatrics and the American Board of Psychiatry and Neurology with Special Competence in Child Neurology. He is a past president of the Association of University Professors of Neurology, the Professors of Child Neurology, and the International Society for Developmental Neuroscience. He is also a Fellow of the Royal College of Physicians an elected member of the National Academy of Medicine. In 2006, Dr. Mobley was named a Fellow of the American Association for the Advancement of Science, in 2011 received the International Sisley-Jérôme Lejeune Prize for research in Down Syndrome, and in 2014 was named to the Johns Hopkins Society of Scholars. Dr. Mobley currently serves as president of the T21 Research Society. In 2019 he was appointed interim Director of the Sanford Institute for Empathy and Compassion. His research focuses on the biology of Alzheimer's disease, especially as manifest in those with Down syndrome. It encompasses studies that extend from basic cellular mechanisms to the discovery of treatments and to the compassionate care of these individuals.

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Lecture / Discussion Thu, 24 Feb 2022 15:46:30 -0500 2022-03-17T12:00:00-04:00 2022-03-17T13:00:00-04:00 Palmer Commons Life Sciences Institute (LSI) Lecture / Discussion Life Sciences Institute Seminar Series
EEB Thursday Seminar: Genetic causes and organismal consequences of metabolic enzyme evolution (March 17, 2022 4:00pm) https://events.umich.edu/event/86328 86328-21632729@events.umich.edu Event Begins: Thursday, March 17, 2022 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Our weekly seminar series featuring internal and external speakers in the field of ecology and evolutionary biology.

This seminar will be in person and livestreamed on Zoom (link this page)

Image: The crystal structure is freely available online through the protein database (https://www.rcsb.org/structure/4iq8). Its specific structural ID is 4iq8. Mo processed the raw structure using a protein visualization software (PyMol) to display its most likely structure as a ribbon dimer and highlighted some residues of interest.

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Workshop / Seminar Tue, 15 Mar 2022 12:46:16 -0400 2022-03-17T16:00:00-04:00 2022-03-17T17:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Illustration of an enzyme
BioArtography - Call for Images (March 18, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701909@events.umich.edu Event Begins: Friday, March 18, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-18T00:00:00-04:00 2022-03-18T23:59:00-04:00 BioArtography Other U-M BioArtography
U-M Structure Seminar: "High throughput screening of small molecule binding partners for the FMN riboswitch by a multidisciplinary approach" (March 18, 2022 10:00am) https://events.umich.edu/event/85436 85436-21626423@events.umich.edu Event Begins: Friday, March 18, 2022 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

Elizabeth Tidwell
Graduate Student
University of Michigan, Koutmos Lab

Hybrid: LSI Library and Zoom - https://umich.zoom.us/j/97763780708 (Password: structure)

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Workshop / Seminar Thu, 03 Mar 2022 11:40:42 -0500 2022-03-18T10:00:00-04:00 2022-03-18T11:00:00-04:00 Life Sciences Institute U-M Structural Biology Workshop / Seminar U-M Structure
MCDB Seminar> Chemical Biology and Proteomic Approaches to Rare Disease and Cancer (March 18, 2022 12:00pm) https://events.umich.edu/event/90411 90411-21670716@events.umich.edu Event Begins: Friday, March 18, 2022 12:00pm
Location: Off Campus Location
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Yanzhuang Wang

Virtual event: For Zoom link and passcode, see the Weekly Update or
email: mcdb.seminar.info@umich.edu

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Workshop / Seminar Wed, 09 Mar 2022 14:14:00 -0500 2022-03-18T12:00:00-04:00 2022-03-18T13:00:00-04:00 Off Campus Location Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow MCDB initials and microscope cartoon on blue background
BioArtography - Call for Images (March 19, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701910@events.umich.edu Event Begins: Saturday, March 19, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-19T00:00:00-04:00 2022-03-19T23:59:00-04:00 BioArtography Other U-M BioArtography
2022 University of Michigan Brain Bee (March 19, 2022 12:00pm) https://events.umich.edu/event/92806 92806-21695825@events.umich.edu Event Begins: Saturday, March 19, 2022 12:00pm
Location: Michigan League
Organized By: Michigan Brain Bee

The university of Michigan Brain Bee is a neuroscience competition open to all Michigan students in grades 9-12! The winner of the Michigan Brain Bee will win 250$ and the right to represent Michigan in the National Brain Bee, held remotely on April 9th, 2022. To learn more information and to register please see the link below!
https://sites.google.com/umich.edu/brainbee

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Fair / Festival Fri, 25 Feb 2022 14:39:38 -0500 2022-03-19T12:00:00-04:00 2022-03-19T17:00:00-04:00 Michigan League Michigan Brain Bee Fair / Festival Michigan Brain Bee Logo
17th Annual Early Career Scientists Symposium (March 19, 2022 2:00pm) https://events.umich.edu/event/89657 89657-21664739@events.umich.edu Event Begins: Saturday, March 19, 2022 2:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

The Department of Ecology and Evolutionary Biology (EEB) at the University of Michigan presents the 17th Annual Early Career Scientists Symposium: Racial Justice and Anti-Racist Research in EEB. We are delighted to announce that our featured speaker, Steward Pickett, distinguished urban ecologist from the Cary Institute and this year’s eminent ecologist of the Ecological Society of America, will open the symposium. A panel discussion led by Nicholas Reo, Associate Professor of Native American Studies at Dartmouth will bring the symposium to its conclusion.

Eight early career scholars who are transforming our discipline through anti-racist and justice-centered research that pushes our understanding of the links between EEB research and society, will present their perspectives in many areas of EEB, such as Global Environmental Change, Genomics and Population Genetics, Urban Ecology and Evolution, Environmental History, STEM Education, Marine Ecology, Water Security, Theoretical Ecology and Evolution, Global Food Systems, and Disease Ecology. The goal of this symposium is to provide a space for the EEB community to think imaginatively about the future of our discipline.

The symposium will begin on Saturday, March 19, 2022 (2 - 6 pm EDT) in-person and live-streamed, followed by three consecutive virtual Fridays from March 25– April 8, 2022 (noon - 2 pm EDT). Two to three participants will present each Friday, followed by a moderated discussion.

**ALL TIMES ARE EDT (Eastern Daylight Time)**

While the symposium presents the work of rising early career scientists, it is open to all (i.e., you don’t have to be in your early career to attend).

REGISTRATION is required for in person and Zoom entry. You will be provided with the link and passcode upon registration. https://myumi.ch/ECSSregister

You must complete the UM ResponsiBLUE short questionnaire before you come to campus https://responsiblue.umich.edu/home

Please contact the planning committee with questions: ecss-2022@umich.edu

SPECIAL THANKS TO COSPONSORS CEW+ (Center for the Education of Women+) Irma M. Wyman Grant Program Fund and the Rackham Faculty Allies Diversity Grant!

Art by John Megahan based on a photo by Nick Reo. About the photo: Kanaka Maoli and Anishinaabe land and language warriors visit and exchange knowledge at Hale O Kuhio, a structure erected in 2018 to assert the unfulfilled mandate of the Hawaiian Homes Commission Act of 1920.

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Conference / Symposium Fri, 04 Mar 2022 15:27:44 -0500 2022-03-19T14:00:00-04:00 2022-03-19T18:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Conference / Symposium Art by John Megahan based on a photo by Nick Reo. Kanaka Maoli and Anishinaabe land and language warriors visit and exchange knowledge at Hale O Kuhio, a structure erected in 2018 to assert the unfulfilled mandate of the Hawaiian Homes Commission Act of 1920.
BioArtography - Call for Images (March 20, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701911@events.umich.edu Event Begins: Sunday, March 20, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-20T00:00:00-04:00 2022-03-20T23:59:00-04:00 BioArtography Other U-M BioArtography
3rd Year Graduate Student Seminars (March 21, 2022 12:00am) https://events.umich.edu/event/91691 91691-21681612@events.umich.edu Event Begins: Monday, March 21, 2022 12:00am
Location: Off Campus Location
Organized By: Department of Chemistry

Inorganic
tba

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Other Mon, 21 Mar 2022 18:15:28 -0400 2022-03-21T00:00:00-04:00 2022-03-21T00:00:00-04:00 Off Campus Location Department of Chemistry Other
BioArtography - Call for Images (March 21, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701912@events.umich.edu Event Begins: Monday, March 21, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-21T00:00:00-04:00 2022-03-21T23:59:00-04:00 BioArtography Other U-M BioArtography
Sea Changes: Experimental Collaborations across the Indian Ocean (March 21, 2022 12:00pm) https://events.umich.edu/event/89835 89835-21665913@events.umich.edu Event Begins: Monday, March 21, 2022 12:00pm
Location: Off Campus Location
Organized By: Institute for Social Research

Sea Changes: Experimental Collaborations across the Indian Ocean
Vivian Choi, St. Olaf College

Monday, Mar. 21, Open Talks will be held noon to 1pm, and the Grad Workshops will be held 1 to 3pm.
In-person in ISR-Thompson 6050
Presentations will also be available online via Zoom

Abstract:
Inspired by ethnographic accounts recounting the colors of the Indian Ocean in Eastern Sri Lanka, this talk explores the colors of the Indian Ocean, as social, political, and material reflections of life and death. While oceans are almost always described and associated with the color blue, these descriptions of past disasters — the black sludgy waters of the 2004 Indian Ocean tsunami and the red, blood-tinged sea from civil war violence — harken to the Indian Ocean’s significance as a reminder and a harbinger of danger. Scaling up, I then turn to ocean color science, which charts and models the presence or absence of phytoplankton as an indicator of the rapidly warming Indian Ocean basin, changing its hues to a deeper green and signaling broader concerns for and relations with biological life, weather, atmosphere and land. What might a broader spectrum of hues offer in contrast to dominant economic and security narratives of bluing? What might attention to Indian Ocean colors offer to examine the social and ecological impacts of planetary risk and danger?

This is a part of the Research Center for Group Dynamics (RCGD) Winter 2022 Series - "Water Ways: New Social Science, Science Studies, and Environmental Approaches to Water"

This is also a part of the class Anthrcul 558 section 002

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Presentation Mon, 21 Mar 2022 12:33:43 -0400 2022-03-21T12:00:00-04:00 2022-03-21T15:00:00-04:00 Off Campus Location Institute for Social Research Presentation event flyer
Inaugural RNA Therapeutics Seminar (March 21, 2022 3:00pm) https://events.umich.edu/event/93388 93388-21704102@events.umich.edu Event Begins: Monday, March 21, 2022 3:00pm
Location: Palmer Commons
Organized By: Center for RNA Biomedicine

Michelle Hastings, Ph.D.
Professor, Cell Biology and Anatomy
Director, Center for Genetic Diseases
Rosalind Franklin University of Medicine and Science

This is an internal U-M event

Hybrid event:
In-person: Palmer Commons, Forum Hall
Zoom: https://myumi.ch/DJ6ky

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Lecture / Discussion Mon, 21 Mar 2022 07:09:36 -0400 2022-03-21T15:00:00-04:00 2022-03-21T16:00:00-04:00 Palmer Commons Center for RNA Biomedicine Lecture / Discussion Michelle Hastings, Rosalind Franklin University
BioArtography - Call for Images (March 22, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701913@events.umich.edu Event Begins: Tuesday, March 22, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-22T00:00:00-04:00 2022-03-22T23:59:00-04:00 BioArtography Other U-M BioArtography
CSCS Hybrid Seminar: The role of non-conservative interactions in non-equilibrium stochastic systems (March 22, 2022 11:30am) https://events.umich.edu/event/93138 93138-21700936@events.umich.edu Event Begins: Tuesday, March 22, 2022 11:30am
Location: Weiser Hall
Organized By: The Center for the Study of Complex Systems

HYBRID SEMINAR
https://umich.zoom.us/j/96616169868 | Weiser Hall Room 747
Password: CSCS (all caps)

Abstract: The complex world surrounding us, including all living matter and various artificial complex systems, mostly operates far from thermal equilibrium. A major goal of modern statistical physics and thermodynamics is to unravel the fundamental principles that govern the individual dynamics and collective behavior of such nonequilibrium systems, like the swarming of fish or flocking of birds. A novel key concept to describe and classify nonequilibrium systems is the stochastic entropy production, which explicitly quantifies the breaking of time-reversal symmetry. However, so far, little attention has been paid to the implications of non-conservative interactions, such as time-delayed (i.e., retarded) or non-reciprocal interactions, which cannot be represented by Hamiltonians contrasting all interactions traditionally considered in statistical physics. Non-conservative interactions indeed emerge commonly in biological, chemical and feedback systems, and are widespread in engineering and machine learning. In this talk, I will use simple time- and space-continuous models to discuss technical challenges and unexpected physical phenomena induced by non-reciprocity [1,2] and time delay [3,4].

[1] Loos and Klapp, NJP 22, 123051 (2020)
[2] Loos, Hermann, and Klapp, Entropy 23, 696 (2021)
[3] Loos and Klapp, Sci. Rep. 9, 2491 (2019)
[4] Holubec, Geiss, Loos, Kroy, and Cichos, PRL 127, 258001 (2021)

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Workshop / Seminar Tue, 08 Mar 2022 15:15:04 -0500 2022-03-22T11:30:00-04:00 2022-03-22T13:00:00-04:00 Weiser Hall The Center for the Study of Complex Systems Workshop / Seminar Sarah Loos
How A Ubiquitin-like Protein Brings Ubiquitin Ligases to Life- Department of Biological Chemistry Annual Greenberg Lecture (March 22, 2022 12:00pm) https://events.umich.edu/event/92442 92442-21691556@events.umich.edu Event Begins: Tuesday, March 22, 2022 12:00pm
Location: Off Campus Location
Organized By: Biological Chemistry

Dr. Brenda Schulman will present the annual Robert Greenberg Lectureship on Tuesday March 22 at 12:00noon via zoom

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Workshop / Seminar Wed, 16 Feb 2022 12:39:14 -0500 2022-03-22T12:00:00-04:00 2022-03-22T13:00:00-04:00 Off Campus Location Biological Chemistry Workshop / Seminar Schulman
LHS Collaboratory (March 22, 2022 12:00pm) https://events.umich.edu/event/90095 90095-21667763@events.umich.edu Event Begins: Tuesday, March 22, 2022 12:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Presentation 1: PCORNet and the PaTH subnetwork

Kathleen McTigue, MD, MPH, MS

In this talk, Kathleen McTigue describes the vision of PCORNet, its organization, and its value to the field of clinical research. PCORNet is divided into regional subnetworks one of which is PaTH. The organization of PaTH along with its priories will be discussed.

Presentation 2: UM’s site within PCORNet/PaTH

David Williams, PhD

The University of Michigan is an institutional member of PaTH/PCORNet.
In this talk, David Williams describes the organization and processes of the UM site within PCORNet/PaTH, studies in which UM participates, and resources for UM investigators interested in participating in PCORNet studies.

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Lecture / Discussion Wed, 15 Dec 2021 22:38:45 -0500 2022-03-22T12:00:00-04:00 2022-03-22T13:30:00-04:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion Collaboratory logo
MCDB Defense> Characterization of unstudied genes important for survival to DNA damage in damage-independent replication fork arrest (March 22, 2022 12:00pm) https://events.umich.edu/event/93111 93111-21700731@events.umich.edu Event Begins: Tuesday, March 22, 2022 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Mentor: Lyle Simmons

Hybrid event:
link and passcode in Weekly Update or
email: mcdb.seminar.info@umich.edu

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Workshop / Seminar Tue, 08 Mar 2022 10:35:53 -0500 2022-03-22T12:00:00-04:00 2022-03-22T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow initials MCDB and cartoon of a microscope on a blue background
Operationalizing the exposome through chemical surveillance & bioeffect monitoring with high-resolution mass spectrometry (March 22, 2022 12:00pm) https://events.umich.edu/event/93450 93450-21704620@events.umich.edu Event Begins: Tuesday, March 22, 2022 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Registration required https://umich.zoom.us/webinar/register/WN_wum4p_pdRMKIixVZJAlicg

Douglas Walker is assistant professor in the Dept of Environmental Medicine & Public Health, Icahn School of Medicine, Mount Sinai. Dr. Walker's research is focused on using untargeted metabolomics to measure environmental exposures, and how exposures lead to biological changes that cause diseases. During his postdoctoral fellowship at Emory University, he acted as Director of Exposome Research for the Clinical Biomarkers Laboratory and was a member of the HERCULES Exposome Research Center. Through application of high-resolution mass spectrometry platforms, Dr. Walker has shown it is possible to provide measures of 10,000-100,000 chemical signals in a cost-effective manner using a single human blood sample, providing a key advance for nutritional assessment, precision medicine and exposome research. At Mount Sinai, his research will be focus on continued development and application of advanced analytical strategies for measuring the occurrence, distribution and magnitude of previously unidentified environmental exposures and assist in delineating the mechanisms underlying environment-related diseases in humans.

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Lecture / Discussion Tue, 15 Mar 2022 13:21:33 -0400 2022-03-22T12:00:00-04:00 2022-03-22T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Dr. Douglas Walker (Mt. Sinai) presents the M-LEEaD Environmental Research Seminar
BioArtography - Call for Images (March 23, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701914@events.umich.edu Event Begins: Wednesday, March 23, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-23T00:00:00-04:00 2022-03-23T23:59:00-04:00 BioArtography Other U-M BioArtography
BioArtography - Call for Images (March 24, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701915@events.umich.edu Event Begins: Thursday, March 24, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-24T00:00:00-04:00 2022-03-24T23:59:00-04:00 BioArtography Other U-M BioArtography
DCM&B Tools and Technology Seminar (March 24, 2022 12:00pm) https://events.umich.edu/event/89811 89811-21665889@events.umich.edu Event Begins: Thursday, March 24, 2022 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

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Presentation Tue, 07 Dec 2021 09:06:13 -0500 2022-03-24T12:00:00-04:00 2022-03-24T13:00:00-04:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
EEB Thursday Seminar: Assembling communities in a changing world: how changing climates and invading species are reshaping our ecosystems (March 24, 2022 4:00pm) https://events.umich.edu/event/85737 85737-21628576@events.umich.edu Event Begins: Thursday, March 24, 2022 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Our weekly seminar series featuring internal and external speakers in the field of ecology and evolutionary biology.

This seminar will be in person and livestreamed on Zoom (link this page).

Image: Megan Ryan

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Workshop / Seminar Mon, 14 Mar 2022 12:23:54 -0400 2022-03-24T16:00:00-04:00 2022-03-24T17:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Two people walking on a trail away from the camera through the woods
BioArtography - Call for Images (March 25, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701916@events.umich.edu Event Begins: Friday, March 25, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-25T00:00:00-04:00 2022-03-25T23:59:00-04:00 BioArtography Other U-M BioArtography
6th Annual RNA Symposium (March 25, 2022 8:00am) https://events.umich.edu/event/93125 93125-21700908@events.umich.edu Event Begins: Friday, March 25, 2022 8:00am
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Symposium Agenda

8:30 / Morning Welcome: President Mary Sue Coleman
8:40 / Jack Szostak "The emergence of RNA from heterogeneous prebiotic chemistry"
9:35 / Gigi Storz "RNA-mediated regulation within protein-coding sequences"
10:30 / coffee break
10:55 / Chris Burge "Impact of RNA-Binding Proteins on Human Genomic Variation"
12:00 / Lunch - please register for free box lunch
1:00 / Afternoon Welcome: Rebecca Cunningham, Vice President for Research
1:10 / Wendy Gilbert “Decoding the untranslated”
2:05 / Michelle Hastings "Splice-Modulating Antisense Oligonucleotides for the Treatment of Disease"
2:55 / Panel discussion with keynote speakers
Topic: Future of RNA Therapeutics, moderated by John Androsavich, Pfizer Global Lead, RNA Medicine

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Lecture / Discussion Wed, 16 Mar 2022 15:43:32 -0400 2022-03-25T08:00:00-04:00 2022-03-25T16:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion 6th Annual RNA Symposium
Beneficial virus: evolutionary, modeling & clinical perspectives on phage (March 25, 2022 9:00am) https://events.umich.edu/event/88027 88027-21648632@events.umich.edu Event Begins: Friday, March 25, 2022 9:00am
Location: Rackham Graduate School (Horace H.)
Organized By: MAC-EPID

SPEAKERS INCLUDE:

Stephanie Strathdee, PhD (Associate Dean of Global Health Sciences; Harold Simon Professor, UCSD Department of Medicine; Co-Director, Center for Innovative Phage Applications and Therapeutics; Author of The Perfect Predator)

Vivek Mutalik, PhD (Staff Scientist, Environmental Genomics and Systems Biology: Comparative and Functional Genomics; Biological Systems and Engineering: Organismal Systems & Bioresilience, Biodesign at Lawrence Berkeley National Laboratory)

Samuel Brown, PhD (Professor, Georgia Tech Biological Sciences)

Gina Suh, M.D. (Senior Associate Consultant, Division of Infectious Diseases, Department of Internal Medicine. Assistant Professor of Medicine, Mayo Clinic)

* * * * *
Coffee hour directly following talks.
Please register for this free symposium since lunch will be provided. Thank you!

For more information and registration for this FREE event:
www.MAC-EPID.org
Anna Cronenwett, weaverd@umich.edu

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Conference / Symposium Thu, 07 Oct 2021 13:05:57 -0400 2022-03-25T09:00:00-04:00 2022-03-25T16:00:00-04:00 Rackham Graduate School (Horace H.) MAC-EPID Conference / Symposium Event Flyer
17th Annual Early Career Scientists Symposium (March 25, 2022 12:00pm) https://events.umich.edu/event/89659 89659-21664740@events.umich.edu Event Begins: Friday, March 25, 2022 12:00pm
Location: Off Campus Location
Organized By: Ecology and Evolutionary Biology

The Department of Ecology and Evolutionary Biology (EEB) at the University of Michigan presents the 17th Annual Early Career Scientists Symposium: Racial Justice and Anti-Racist Research in EEB. We are delighted to announce that our featured speaker, Steward Pickett, distinguished urban ecologist from the Cary Institute and this year’s eminent ecologist of the Ecological Society of America, will open the symposium. A panel discussion led by Nicholas Reo, Associate Professor of Native American Studies at Dartmouth will bring the symposium to its conclusion.

Eight early career scholars who are transforming our discipline through anti-racist and justice-centered research that pushes our understanding of the links between EEB research and society, will present their perspectives in many areas of EEB, such as Global Environmental Change, Genomics and Population Genetics, Urban Ecology and Evolution, Environmental History, STEM Education, Marine Ecology, Water Security, Theoretical Ecology and Evolution, Global Food Systems, and Disease Ecology. The goal of this symposium is to provide a space for the EEB community to think imaginatively about the future of our discipline.

The symposium will begin on Saturday, March 19, 2022 (2 - 6 pm EDT) in-person and live-streamed, followed by three consecutive virtual Fridays (noon - 2 pm EDT) from March 25– April 8, 2022. Two to three participants will present each Friday, followed by a moderated discussion. For the symposium, we consider early career scientists as senior graduate students (who stand to receive their Ph.D. within two years), postdoctoral researchers, faculty or staff scientists within their first or second year, and researchers at equivalent career stages who are not affiliated with an academic institution.

While the symposium presents the work of rising early career scientists, it is open to all (i.e., you don’t have to be in your early career to attend).

Please contact the planning committee with questions: ecss-2022@umich.edu.

REGISTRATION is required for Zoom entry. You will be provided with the link and passcode upon registration. https://myumi.ch/ECSSregister

SPECIAL THANKS TO COSPONSORS CEW+ (Center for the Education of Women+) Irma M. Wyman Grant Program Fund and the Rackham Faculty Allies Diversity Grant!

Art by John Megahan based on a photo by Nick Reo. Kanaka Maoli and Anishinaabe land and language warriors visit and exchange knowledge at Hale O Kuhio, a structure erected in 2018 to assert the unfulfilled mandate of the Hawaiian Homes Commission Act of 1920.

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Livestream / Virtual Fri, 04 Mar 2022 15:29:01 -0500 2022-03-25T12:00:00-04:00 2022-03-25T14:00:00-04:00 Off Campus Location Ecology and Evolutionary Biology Livestream / Virtual Art by John Megahan based on a photo by Nick Reo. Kanaka Maoli and Anishinaabe land and language warriors visit and exchange knowledge at Hale O Kuhio, a structure erected in 2018 to assert the unfulfilled mandate of the Hawaiian Homes Commission Act of 1920.
MCDB Seminar> Leaving a mark: Formation of distinct plasma membrane domains on the pollen surface (March 25, 2022 12:00pm) https://events.umich.edu/event/90413 90413-21670788@events.umich.edu Event Begins: Friday, March 25, 2022 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Cora MacAlister

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Workshop / Seminar Fri, 04 Mar 2022 11:57:01 -0500 2022-03-25T12:00:00-04:00 2022-03-25T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar images of pollen in yin yang pattern on black background
UM Structure Seminar: "Structures in situ: Discovering a new lattice inside alpha-carboxysomes" (March 25, 2022 12:00pm) https://events.umich.edu/event/89500 89500-21663332@events.umich.edu Event Begins: Friday, March 25, 2022 12:00pm
Location: Life Sciences Institute
Organized By: U-M Structural Biology

Lauren Ann Metskas, Ph.D.
Assistant Professor
Purdue University

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Lecture / Discussion Mon, 28 Feb 2022 08:56:39 -0500 2022-03-25T12:00:00-04:00 2022-03-25T13:00:00-04:00 Life Sciences Institute U-M Structural Biology Lecture / Discussion U-M Structure
BioArtography - Call for Images (March 26, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701917@events.umich.edu Event Begins: Saturday, March 26, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-26T00:00:00-04:00 2022-03-26T23:59:00-04:00 BioArtography Other U-M BioArtography
BioArtography - Call for Images (March 27, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701918@events.umich.edu Event Begins: Sunday, March 27, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-27T00:00:00-04:00 2022-03-27T23:59:00-04:00 BioArtography Other U-M BioArtography
3rd year Graduate Student Seminars (March 28, 2022 12:00am) https://events.umich.edu/event/91692 91692-21681613@events.umich.edu Event Begins: Monday, March 28, 2022 12:00am
Location: Off Campus Location
Organized By: Department of Chemistry

Inorganic
tba

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Other Mon, 28 Mar 2022 18:15:25 -0400 2022-03-28T00:00:00-04:00 2022-03-28T00:00:00-04:00 Off Campus Location Department of Chemistry Other
BioArtography - Call for Images (March 28, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701919@events.umich.edu Event Begins: Monday, March 28, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-28T00:00:00-04:00 2022-03-28T23:59:00-04:00 BioArtography Other U-M BioArtography
RNA Innovation Seminar: "Marvelous U: Canonical and non-canonical functions of uridine modifying enzymes in health and disease" (March 28, 2022 4:00pm) https://events.umich.edu/event/92831 92831-21697176@events.umich.edu Event Begins: Monday, March 28, 2022 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

In-person/Hybrid seminar

Talk title: “Marvelous U: Canonical and non-canonical functions of uridine modifying enzymes in health and disease"

Keywords: RNA modifications, RNA processing, RNA folding, pre-mRNA, tRNA, translation, cancer

Abstract: RNA modifications are essential for human health—too much or too little leads to serious illnesses ranging from neurodevelopmental disorders to cancer. We are working to uncover the RNA targets of RNA modifying enzymes that are dysregulated in disease and to understand their molecular and organismal roles. Recent advances in detecting the modified nucleosides pseudouridine and dihydrouridine reveal complex landscapes that include pre-messenger RNA and diverse classes of noncoding RNA in yeast and human cells. I will give an update on our progress towards answering three questions: How are specific RNA sites selected for modification and how is this process regulated? What are the molecular consequences of mRNA and non-coding RNA modifications? How do specific defects in RNA metabolism result in organismal phenotypes, including disease?

Brief Bio:
Wendy Gilbert is an Associate Professor of Molecular Biophysics and Biochemistry. Her work focuses on regulatory elements in messenger RNA that control the cellular expression of the information stored in the genetic code. She earned her PhD at UCSF with Christine Guthrie, studying mRNA export and being fascinated by the exquisite mechanisms that couple export-competence to completion of RNA processing. As a postdoc in Jennifer Doudna’s lab at UC Berkeley, she uncovered a non-canonical mechanism of translation initiation. She started her lab at MIT in 2008 and joined the faculty at Yale in 2017. Her lab’s current work ranges widely across RNA biology with the unifying theme of elucidating the molecular mechanisms of RNA regulatory elements controlling mRNA biogenesis, translation and decay. Most recently, this has been in the area of RNA base modification. She was recognized with the RNA Society’s Early Career Award in 2017 for her “paradigm-altering contributions to the field of post-transcriptional gene regulation.”

If you are having trouble registering, please contact Martina Jerant at mjerant@umich.edu

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Lecture / Discussion Mon, 14 Mar 2022 15:29:11 -0400 2022-03-28T16:00:00-04:00 2022-03-28T17:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion Wendy Gilbert, Yale School of Medicine
BioArtography - Call for Images (March 29, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701920@events.umich.edu Event Begins: Tuesday, March 29, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-29T00:00:00-04:00 2022-03-29T23:59:00-04:00 BioArtography Other U-M BioArtography
Mechanisms of Organelle Trafficking, Inheritance, and Homeostasis in Bacteria- Department of Biological Chemistry Seminar (March 29, 2022 12:00pm) https://events.umich.edu/event/92443 92443-21691557@events.umich.edu Event Begins: Tuesday, March 29, 2022 12:00pm
Location: Medical Science Unit I
Organized By: Biological Chemistry

Dr. Vecchiarelli will present a seminar in person in room 5330 MS I at 12 noon

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Workshop / Seminar Wed, 16 Feb 2022 12:43:04 -0500 2022-03-29T12:00:00-04:00 2022-03-29T13:00:00-04:00 Medical Science Unit I Biological Chemistry Workshop / Seminar Vecchiarelli
A New Way to Stop the Spread of Viral Respiratory Infections (March 29, 2022 4:00pm) https://events.umich.edu/event/93801 93801-21708246@events.umich.edu Event Begins: Tuesday, March 29, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

I want to speak about viral respiratory diseases, such as influenza and COVID-19. When COVID-19 first appeared, public health authorities worried about the new coronavirus being spread by contact with large fluid droplets or by residues upon droplet evaporation. The guidance for individual behavior that was given included washing hands, cleaning groceries, wearing face coverings, avoiding people who sneeze or cough, and keeping some social distance apart from other individuals. But a detailed understanding of flu transmission, which took decades to develop, led scientists to understand only relatively recently that SARS-CoV-2 follows the same path of airborne transmission. Researchers found that the virus is breathed out in small particles by infected individuals while talking, singing, sneezing, and coughing. And these viruses have been found in many indoor environments. Those infected can even spread the virus when showing no symptoms of being sick, which shows that transmission does not depend on coughing or sneezing. Large wet droplets are not required for transmission.

The transmission of many infectious diseases requires that pathogens can survive, that is, remain infectious, in the environment, outside the host. It has long been recognized that viral respiratory diseases show a seasonal variation in temperate parts of the world, such that they increase in the winter but decrease in the summer. This behavior is strongly correlated with outside temperature, but viruses are hardy and are not killed by temperature changes of the outdoors. Instead, evidence has accumulated that the correlation is strongest with relative humidity in which viruses show U-shaped viability, surviving best in high or low humidity but surviving much more poorly in the relative humidity range of 40 to 60 %.[1] People in temperate regions of the world spend about 90% of their time indoors, and the relative humidity of indoor air is typically much reduced in the wintertime caused by heating of the indoor air which is necessary to keep people warm.[2] Evidence will be presented that relative humidity affects the evaporation rate of aqueous microdroplets (aerosols) in the air, and that relative humidity values of 40-60% provide enough time to kill viruses in aqueous microdroplets.[3] This conclusion explains this seasonal variation, which has heretofore been quite puzzling and often ignored. We find that this killing is promoted by the presence of reactive oxygen species (ROS) in aqueous microdroplets in the size range of 1 to 20 microns in diameter. The possible mechanism for the formation of ROS will be discussed.

References:

1. Lin K, Marr LC. (2020) "Humidity-dependent decay of viruses, but not bacteria, in aerosols and droplets follows disinfection kinetics," Environmental Science & Technology 54, 1024-1032.
2. Bozic A, Kanduc M. (2021) "Relative humidity in droplet and airborne transmission of disease." Journal of Biological Physics 47,1-29.
3. Dulay MT, Huerta Aguila AC, Chamberlayne CF, Zare RN, Davidse A, Vukovic S. (2021), "Effect of Relative Humidity on Hydrogen Peroxide Production in Water Droplets," QRB Discovery 2, e8, 1-6.





Dick Zare (Stanford University)

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Other Tue, 29 Mar 2022 18:15:35 -0400 2022-03-29T16:00:00-04:00 2022-03-29T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
BioArtography - Call for Images (March 30, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701921@events.umich.edu Event Begins: Wednesday, March 30, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-30T00:00:00-04:00 2022-03-30T23:59:00-04:00 BioArtography Other U-M BioArtography
The Role of Specialized Cell Cycles During Erythroid Lineage Development (March 30, 2022 9:30am) https://events.umich.edu/event/91810 91810-21683063@events.umich.edu Event Begins: Wednesday, March 30, 2022 9:30am
Location: Off Campus Location
Organized By: Cell & Developmental Biology

CDB 2022 Seminar Series (In person & Virtual):

We are pleased to welcome Merav Socolovsky, Ph.D., to present on Wednesday, March 30, 2022, from 9:30 – 10:30 am, (BSRB - Kahn Auditorium and virtual event). She will present “The Role of Specialized Cell Cycles During Erythroid Lineage Development.”

Zoom Meeting link:
https://umich.zoom.us/j/91043855664

Hosted by Doug Engel, Ph.D.

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Lecture / Discussion Thu, 10 Mar 2022 10:30:38 -0500 2022-03-30T09:30:00-04:00 2022-03-30T10:30:00-04:00 Off Campus Location Cell & Developmental Biology Lecture / Discussion The Role of Specialized Cell Cycles During Erythroid Lineage Development
DCMB / CCMB Weekly Seminar presents Rehan Akbani, PhD (Associate Professor, University of Texas, MD Anderson Cancer Center) (March 30, 2022 4:00pm) https://events.umich.edu/event/93933 93933-21711327@events.umich.edu Event Begins: Wednesday, March 30, 2022 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

The TP53 tumor suppressor gene is frequently mutated in human cancers. We illustrate the “omics” landscape of the TP53 pathway across five data platforms in 10,225 patient samples from 33 cancers reported by The Cancer Genome Atlas (TCGA). More than 91% of TP53-mutant cancers exhibit second allele loss by mutation, chromosomal deletion, or copy-neutral loss of heterozygosity. TP53 mutations are associated with enhanced chromosomal instability, including increased amplification of oncogenes and deep deletion of tumor suppressor genes. Tumors with TP53 mutations differ from their non-mutated counterparts in RNA, miRNA, and protein expression patterns, with mutant TP53 tumors displaying enhanced expression of cell cycle progression genes and proteins. A mutant TP53 RNA expression signature shows significant correlation with reduced survival in 11 cancer types. Pathway activity scores were computed for all the samples using mRNA expression levels of ten TP53 pathway member genes. Gynecologic cancers show high activity of the pathway. The pathway is correlated with immune infiltration and EMT, and anti-correlated with RTK and RAS/MAPK pathways. In particular, a strong correlation with immune infiltration is observed in breast cancer. ATAC-seq data also show high chromatin accessibility of the pathway genes in breast cancer. Thus, the TP53 pathway has profound effects on tumor cell genomic structure, expression, and clinical outlook depending on tumor type.

Short Bio
Dr. Rehan Akbani is an Associate Professor at the University of Texas MD Anderson Cancer Center in Houston, Texas, in the Department of Bioinformatics and Computational Biology. He has worked at MD Anderson since 2009. He has played many leadership roles in major enterprises, including as PI on TCGA’s MD Anderson Genome Data Analysis Center (GDAC) grant. Within the TCGA consortium, he led four of TCGA’s analysis working groups and he’s been a co-author on each one of TCGA’s 33 marker papers and 27 pan-cancer papers since 2009. His primary contributions have been leading the analysis of proteomics data, and batch effects and quality control of omics data. He won the AACR “Team Science Award” in 2020 for his work in TCGA. He was conferred the “Highly Cited Researchers 2019” award by Web of Science for co-authoring the most highly cited papers in the past decade. He has over 87,700 citations and an h-index of 78 on Google Scholar. In 2014, he won the “Test of Time” award from the European Conference on Machine Learning (ECML) for publishing the most highly cited paper in ECML a decade ago. Currently, Dr. Akbani is the Co-Director of MD Anderson’s proteomics core and Co-Director of the metabolomics core, where he’s led the development of software pipelines for normalizing raw data and generating customer reports semi-automatically. He’s also contributed proteomics data analysis for projects including the Cancer Cell Line Encyclopedia (CCLE) and the MD Anderson Cell Line Project (MCLP).

Host: Veera Baladandayuthapani, Ph.D.
https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Lecture / Discussion Thu, 24 Mar 2022 12:32:18 -0400 2022-03-30T16:00:00-04:00 2022-03-30T17:00:00-04:00 Off Campus Location DCMB Seminar Series Lecture / Discussion Rehan Akbani, PhD (Associate Professor, University of TX MD Anderson Cancer Center)
BioArtography - Call for Images (March 31, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701922@events.umich.edu Event Begins: Thursday, March 31, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-31T00:00:00-04:00 2022-03-31T23:59:00-04:00 BioArtography Other U-M BioArtography
“Bioengineered Synthetic Hydrogels for Regenerative Medicine" (March 31, 2022 12:00pm) https://events.umich.edu/event/92752 92752-21695194@events.umich.edu Event Begins: Thursday, March 31, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

Andrés J. García is the Executive Director of the Petit Institute for Bioengineering and Bioscience and Regents’ Professor at the Georgia Institute of Technology. Dr. García’s research program integrates innovative engineering, materials science, and cell biology concepts and technologies to create cell-instructive biomaterials for regenerative medicine and generate new knowledge in mechanobiology. This cross-disciplinary effort has resulted in new biomaterial platforms that elicit targeted cellular responses and tissue repair in various biomedical applications, innovative technologies to study and exploit cell adhesive interactions, and new mechanistic insights into the interplay of mechanics and cell biology.

In addition, his research has generated intellectual property and licensing agreements with start-up and multi-national companies. He is a co-founder of 3 start-up companies (CellectCell, CorAmi Therapeutics, iTolerance). He has received several distinctions, including the NSF CAREER Award, Young Investigator Award from the Society for Biomaterials, Georgia Tech’s Outstanding Interdisciplinary Activities Award, the Clemson Award for Basic Science from the Society for Biomaterials, the International Award from the European Society for Biomaterials, and Georgia Tech’s Class of 1934 Distinguished Professor Award.

He is an elected Fellow of Biomaterials Science and Engineering (by the International Union of Societies of Biomaterials Science and Engineering), Fellow of the American Association for the Advancement of Science, Fellow of the American Society of Mechanical Engineers, and Fellow of the American Institute for Medical and Biological Engineering. He served as President for the Society for Biomaterials in 2018-2019. He is an elected member of the National Academy of Engineering, the National Academy of Medicine, and the National Academy of Inventors.

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Lecture / Discussion Fri, 18 Mar 2022 10:06:32 -0400 2022-03-31T12:00:00-04:00 2022-03-31T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Lecture / Discussion Andrés J. García, Ph.D.
DCM&B Tools and Technology Seminar (March 31, 2022 12:00pm) https://events.umich.edu/event/89812 89812-21665890@events.umich.edu Event Begins: Thursday, March 31, 2022 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

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Presentation Thu, 27 Jan 2022 12:48:19 -0500 2022-03-31T12:00:00-04:00 2022-03-31T13:00:00-04:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
EEB Thursday Seminar: Intractable species boundaries and their implications for speciation and the assembly of continental faunas (March 31, 2022 4:00pm) https://events.umich.edu/event/86026 86026-21631132@events.umich.edu Event Begins: Thursday, March 31, 2022 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Our weekly seminar series featuring internal and external speakers in the field of ecology and evolutionary biology. This seminar will be in person and livestreamed on Zoom (link this page).

Image: Ivan Prates

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Workshop / Seminar Thu, 24 Mar 2022 10:54:15 -0400 2022-03-31T16:00:00-04:00 2022-03-31T17:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Complex species boundaries impact inferences in macroecology and macroevolution. Top left, the relationship between geographic range size and climatic niche breadth across 900 species of Australian lizards and snakes. Top right, major biomes in the Australian continent. Center, illustration of molecular delimitation of operational candidate species in a subclade of lizards; genotypic clustering and phylogenetic patterns are shown. Bottom: Representative examples of variation in range size in Ctenotus lizards.
Physics-Inspired Machine Learning Methods: A Status Report on Predictive Chemistry (March 31, 2022 4:00pm) https://events.umich.edu/event/91346 91346-21678335@events.umich.edu Event Begins: Thursday, March 31, 2022 4:00pm
Location: Off Campus Location
Organized By: Department of Chemistry

Physical
Teresa Head-Gordon (University of California - Berkeley)

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Other Thu, 31 Mar 2022 18:15:33 -0400 2022-03-31T16:00:00-04:00 2022-03-31T17:30:00-04:00 Off Campus Location Department of Chemistry Other
BioArtography - Call for Images (April 1, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701923@events.umich.edu Event Begins: Friday, April 1, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-01T00:00:00-04:00 2022-04-01T23:59:00-04:00 BioArtography Other U-M BioArtography
17th Annual Early Career Scientists Symposium (April 1, 2022 12:00pm) https://events.umich.edu/event/89659 89659-21664741@events.umich.edu Event Begins: Friday, April 1, 2022 12:00pm
Location: Off Campus Location
Organized By: Ecology and Evolutionary Biology

The Department of Ecology and Evolutionary Biology (EEB) at the University of Michigan presents the 17th Annual Early Career Scientists Symposium: Racial Justice and Anti-Racist Research in EEB. We are delighted to announce that our featured speaker, Steward Pickett, distinguished urban ecologist from the Cary Institute and this year’s eminent ecologist of the Ecological Society of America, will open the symposium. A panel discussion led by Nicholas Reo, Associate Professor of Native American Studies at Dartmouth will bring the symposium to its conclusion.

Eight early career scholars who are transforming our discipline through anti-racist and justice-centered research that pushes our understanding of the links between EEB research and society, will present their perspectives in many areas of EEB, such as Global Environmental Change, Genomics and Population Genetics, Urban Ecology and Evolution, Environmental History, STEM Education, Marine Ecology, Water Security, Theoretical Ecology and Evolution, Global Food Systems, and Disease Ecology. The goal of this symposium is to provide a space for the EEB community to think imaginatively about the future of our discipline.

The symposium will begin on Saturday, March 19, 2022 (2 - 6 pm EDT) in-person and live-streamed, followed by three consecutive virtual Fridays (noon - 2 pm EDT) from March 25– April 8, 2022. Two to three participants will present each Friday, followed by a moderated discussion. For the symposium, we consider early career scientists as senior graduate students (who stand to receive their Ph.D. within two years), postdoctoral researchers, faculty or staff scientists within their first or second year, and researchers at equivalent career stages who are not affiliated with an academic institution.

While the symposium presents the work of rising early career scientists, it is open to all (i.e., you don’t have to be in your early career to attend).

Please contact the planning committee with questions: ecss-2022@umich.edu.

REGISTRATION is required for Zoom entry. You will be provided with the link and passcode upon registration. https://myumi.ch/ECSSregister

SPECIAL THANKS TO COSPONSORS CEW+ (Center for the Education of Women+) Irma M. Wyman Grant Program Fund and the Rackham Faculty Allies Diversity Grant!

Art by John Megahan based on a photo by Nick Reo. Kanaka Maoli and Anishinaabe land and language warriors visit and exchange knowledge at Hale O Kuhio, a structure erected in 2018 to assert the unfulfilled mandate of the Hawaiian Homes Commission Act of 1920.

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Livestream / Virtual Fri, 04 Mar 2022 15:29:01 -0500 2022-04-01T12:00:00-04:00 2022-04-01T14:00:00-04:00 Off Campus Location Ecology and Evolutionary Biology Livestream / Virtual Art by John Megahan based on a photo by Nick Reo. Kanaka Maoli and Anishinaabe land and language warriors visit and exchange knowledge at Hale O Kuhio, a structure erected in 2018 to assert the unfulfilled mandate of the Hawaiian Homes Commission Act of 1920.
MCDB Seminar > Transcriptional reprogramming of neural circuits with social experience (April 1, 2022 12:00pm) https://events.umich.edu/event/92830 92830-21697175@events.umich.edu Event Begins: Friday, April 1, 2022 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Josie Clowney

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Workshop / Seminar Tue, 22 Mar 2022 22:17:26 -0400 2022-04-01T12:00:00-04:00 2022-04-01T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow MCDB initials and Microscope on blue
BioArtography - Call for Images (April 2, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742264@events.umich.edu Event Begins: Saturday, April 2, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-02T00:00:00-04:00 2022-04-02T23:59:00-04:00 BioArtography Other U-M BioArtography
BioArtography - Call for Images (April 3, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742265@events.umich.edu Event Begins: Sunday, April 3, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-03T00:00:00-04:00 2022-04-03T23:59:00-04:00 BioArtography Other U-M BioArtography
BioArtography - Call for Images (April 4, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742266@events.umich.edu Event Begins: Monday, April 4, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-04T00:00:00-04:00 2022-04-04T23:59:00-04:00 BioArtography Other U-M BioArtography
Proteostasis and Viral Evolution (April 4, 2022 4:00pm) https://events.umich.edu/event/85240 85240-21626064@events.umich.edu Event Begins: Monday, April 4, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our group is broadly interested in understanding how cells fold complex proteins, as well as in the design and application of next-generation in vivo directed evolution platforms. In recent work, we used chemical genetic tools for controlling mammalian proteostasis networks to reveal that RNA viruses hijack host chaperones to facilitate their rapid evolution. This phenomenon has proven broadly significant for understanding viral adaptation and pathology. More recently, we discovered that host protein quality control mechanisms (as opposed to folding chaperones) can have the opposite effect on viral evolution -- effectively constraining viral mutational space. The connections drawn between host proteostasis and viral evolution have potentially significant implications for topics including viral host-switching, vaccine development, and the design of improved antiviral therapeutic strategies. Moreover, these principles may provide strategies to turbo-charge directed evolution campaigns aimed at the development of new biotechnologies.

Matthew Shoulders (Massachusetts Institute of Technology)

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Other Mon, 04 Apr 2022 18:15:27 -0400 2022-04-04T16:00:00-04:00 2022-04-04T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
BioArtography - Call for Images (April 5, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742267@events.umich.edu Event Begins: Tuesday, April 5, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-05T00:00:00-04:00 2022-04-05T23:59:00-04:00 BioArtography Other U-M BioArtography
Environmental Injustice in the Southend of Dearborn (April 5, 2022 12:00pm) https://events.umich.edu/event/93452 93452-21704623@events.umich.edu Event Begins: Tuesday, April 5, 2022 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Registration required https://umich.zoom.us/webinar/register/WN_YhR24FAcQUm3sDY3FZmfwg

The next in the R&R series of talks featuring residents and researchers discussing the environment, health and community is "Environmental Injustice in the Southend of Dearborn".

Panelists include Samra'a Luqman, and environmental activist in the Southend of Dearborn and Zeina Reda, a University of Michigan student. Moderated by Natalie Sampson, Associate Professor of Health and Human Services, University of Michigan-Dearborn.

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Lecture / Discussion Tue, 15 Mar 2022 13:53:19 -0400 2022-04-05T12:00:00-04:00 2022-04-05T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion R&R: Residents and Researchers Tuesday Talks at 12 on environment, health, and community
Incorporation and molecular level consequences of uridine mRNA modifications-Department of Biological Chemistry Seminar (April 5, 2022 12:00pm) https://events.umich.edu/event/92444 92444-21691559@events.umich.edu Event Begins: Tuesday, April 5, 2022 12:00pm
Location: Medical Science Unit I
Organized By: Biological Chemistry

Dr. Koutmou will present an in person seminar on 4/5/22 at 12:00 noon in room 5330 MS I

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Workshop / Seminar Tue, 29 Mar 2022 10:34:07 -0400 2022-04-05T12:00:00-04:00 2022-04-05T13:00:00-04:00 Medical Science Unit I Biological Chemistry Workshop / Seminar Koutmou
‘Genetic mechanisms of pediatric renovascular hypertension’ (April 5, 2022 4:00pm) https://events.umich.edu/event/91188 91188-21677134@events.umich.edu Event Begins: Tuesday, April 5, 2022 4:00pm
Location: Off Campus Location
Organized By: Center for Cell Plasticity and Organ Design

The Center for Cell Plasticity and Organ Design is proud to present the following Cross Talk seminar with:

Dawn Marie Coleman, MD, FACS
Handleman Research Professor Associate Professor, Surgery and Pediatrics & Communicable Diseases
and
Santhi K. Ganesh, MD
Associate Professor, Cardiovascular Medicine,
Department of Internal Medicine, Department of Human Genetics

The Cross Talk is entitled, ‘Genetic mechanisms of pediatric renovascular hypertension.'

Moderator: Filip Bednar, MD, PhD, Surgery

For more information, please email: Organogenesis@umich.edu

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Lecture / Discussion Sun, 20 Mar 2022 16:23:49 -0400 2022-04-05T16:00:00-04:00 2022-04-05T17:00:00-04:00 Off Campus Location Center for Cell Plasticity and Organ Design Lecture / Discussion flyer
Mini-Enzymes for Hydrogen Production and Small Molecule Activation (April 5, 2022 4:00pm) https://events.umich.edu/event/84372 84372-21623618@events.umich.edu Event Begins: Tuesday, April 5, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Inorganic
Kara Bren (University of Rochester)

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Other Tue, 05 Apr 2022 18:15:24 -0400 2022-04-05T16:00:00-04:00 2022-04-05T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
BioArtography - Call for Images (April 6, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742268@events.umich.edu Event Begins: Wednesday, April 6, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-06T00:00:00-04:00 2022-04-06T23:59:00-04:00 BioArtography Other U-M BioArtography
Epithelial Oncogenic KRAS Drives Immunosuppression in Pancreatic Cancer (April 6, 2022 9:00am) https://events.umich.edu/event/93433 93433-21704488@events.umich.edu Event Begins: Wednesday, April 6, 2022 9:00am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

We are pleased to announce that Ashley Velez will present her Dissertation Defense on Epithelial Oncogenic KRAS Drives Immunosuppression in Pancreatic Cancer, on April 6, 2022, at 9:00 am in person at Kahn Auditorium (BSRB). and via live stream: Meeting Link: https://umich.zoom.us/j/94003848903 Passcode: KRAS

Hosted By the Dissertation Committee:
Marina Pasca di Magliano, Ph.D., Principal Investigator
Qing Li, MD, Ph.D., Chair
James Moon, Ph.D.
Timothy Frankel, M.D.
Howard Crawford, Ph.D.

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Livestream / Virtual Tue, 15 Mar 2022 08:12:47 -0400 2022-04-06T09:00:00-04:00 2022-04-06T10:00:00-04:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Livestream / Virtual Epithelial Oncogenic KRAS Drives Immunosuppression in Pancreatic Cancer
Immunotherapeutic and Diagnostic Potential of Engineered Materials (April 6, 2022 2:00pm) https://events.umich.edu/event/94118 94118-21722028@events.umich.edu Event Begins: Wednesday, April 6, 2022 2:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Globally, breast cancer has the highest rates of incidence and mortality among women. For breast cancer diagnoses, while there is a 99% five-year relative survival rate for localized disease, survival drops to 29% for progression to metastatic disease. And, although robust advances have been made in the treatment of localized breast cancer, few therapies exist to effectively treat metastases. As such, distant spread marks the disease stage where treatment no longer has curative intent, and disease progression leads to mortality. The increased mortality with metastasis motivates the development of diagnostic and therapeutic strategies for managing metastatic disease, and I hypothesize that the microenvironment at the metastatic niche can serve as a target for these strategies.

First, I present a study investigating the utility of cargo-free PLGA nanoparticles (NPs) that, upon intravenous delivery, can be internalized by myeloid cells and subsequently alter their impact on the metastatic niche. We demonstrated that NPs reduce metastatic colonization of the lungs in a murine model of metastatic triple negative breast cancer (mTNBC). The NPs were found to modulate the immune microenvironment of the lungs, skewing myeloid cells toward inflammatory, anti-tumor phenotypes through single cell RNA sequencing. We then found that the reduction of metastatic spread was dependent on mature T-cells. Finally, NPs were administered in a primary tumor (PT) resection model and shown to lead to clearance of established metastatic lesions when delivered as an adjuvant therapy, following surgical resection.

The treatment of TNBC with immune checkpoint blockade (ICB) therapy, a T-cell targeted immunotherapy, has shown robust improvements in patient outcomes. However, while ICB-sensitive patients have durable responses to therapy, no effective biomarkers are available for predicting ICB-response and stratifying ICB-sensitivity from ICB-resistance. Our lab has previously shown that the immune milieu of a microporous PCL implant, which recapitulates key features of the native metastatic niche, can be longitudinally probed for monitoring 1) progression of cancer and 2) response to a PT resection. I investigate the hypothesis that the microporous implant can be longitudinally probed for ICB-response. Divergent responses in TNBC progression, as a result of anti-PD-1 administration, were identified and gene expression at the implant allowed for the ability to monitor ICB-response. Differential lymphocyte and myeloid cell responses were also identified that are correlative of the divergent responses to therapy. Finally, implant-derived gene expressions were probed prior to treatment to investigate predictive analytes for ICB-response before initiating therapy.

Overall, this dissertation demonstrates the potential for applying engineered materials to 1) modulate cancer-associated myeloid cells to enhance anti-tumor T-cell surveillance with the goal of clearing metastatic disease and 2) probe biomarkers to stratify ICB-response and investigate mechanisms underlying therapy resistance.

Date: Wednesday, April 6, 2022
Time: 2:00 PM EST
Zoom: https://umich.zoom.us/j/94478502873
Chair: Professor Lonnie D. Shea

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Presentation Tue, 29 Mar 2022 13:19:30 -0400 2022-04-06T14:00:00-04:00 2022-04-06T15:00:00-04:00 Off Campus Location Biomedical Engineering Presentation BME Ph.D. Defense
BioArtography - Call for Images (April 7, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742269@events.umich.edu Event Begins: Thursday, April 7, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-07T00:00:00-04:00 2022-04-07T23:59:00-04:00 BioArtography Other U-M BioArtography
2022 Investigators Awards Launch Event (April 7, 2022 10:00am) https://events.umich.edu/event/92973 92973-21698652@events.umich.edu Event Begins: Thursday, April 7, 2022 10:00am
Location: Off Campus Location
Organized By: Precision Health

Join us for a lively, fast-paced series of presentations (3 minutes each!) by our most recently funded project PIs. Hear what exciting challenges they're taking on and see how multidisciplinary teams are working together to improve health.

After these presentations, we will open breakout rooms to invite your ideas on the following topics:
Tackling Health Disparities through Precision Health
New Advances in Health Image Analysis
Using Genetic Information to Individualize Patient Care
Reinforcement Learning & Causal Inference in Healthcare
Learning from Multi-institution EHR data Opportunities to Enhance Data Sharing and Collaboration
What's missing from Precision Health resources?

The launching projects include:
Anouck Girard (COE), Josephine Kasa-Vubu (Med), Michael DiPietro (Med) -- "Using Artificial Intelligence To Broaden and Diversify Outdated Standards for the Determination of Skeletal Maturation in Growing Children"

Todd Hollon (COE), Honglak Lee (COE), Sandra Camelo-Piragua (Med) -- "Rapid Intraoperative Molecular Diagnosis of Diffuse Gliomas Using Stimulated Raman Histology and Deep Neural Networks"

Hui Jiang (SPH) -- "Statistical and Computational Methods for Asymmetric Integration of Datasets from Different Cancers for the Identification of Cancer-related Genes and Biomarkers in Case-control Analyses"

Michael Mathis (Med) -- "Predicting Cardiac Surgery-Associated Acute Kidney Injury using Federated Learning"

Amy Pasternak (Pharm), Vaibhav Sahai (Med) -- "Assessing the Impact of Germline Pharmacogenetics (PGx) on Medication Outcomes and Clinician Prescribing Decisions in Patients with Cancer"

Scott Peltier (BME), Zhongming Liu (BME) -- "Deep Learning for Prediction of Mild Cognitive Impairment and Dementia of the Alzheimer’s Type"

Xu Shi (SPH) -- "Automated Harmonization of Multi-institutional Electronic Health Records Data"


Questions? Contact Tina Creguer, tcreguer@umich.edu.

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Presentation Thu, 03 Mar 2022 16:52:49 -0500 2022-04-07T10:00:00-04:00 2022-04-07T11:30:00-04:00 Off Campus Location Precision Health Presentation Precision Health Investigators Awards
DCM&B Tools and Technology Seminar (April 7, 2022 12:00pm) https://events.umich.edu/event/89813 89813-21665891@events.umich.edu Event Begins: Thursday, April 7, 2022 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

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Presentation Tue, 07 Dec 2021 09:11:01 -0500 2022-04-07T12:00:00-04:00 2022-04-07T13:00:00-04:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
Dynamical network models of the epileptic brain to improve surgical outcomes (April 7, 2022 3:30pm) https://events.umich.edu/event/94203 94203-21724114@events.umich.edu Event Begins: Thursday, April 7, 2022 3:30pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: Biomedical Engineering

Abstract:

Medically-refractory epilepsy (MRE) is a devastating neurological disease that is defined by recurrent and unprovoked seizures that are insufficiently controlled by anti-epileptic medication. If the seizures are originating from a specific region of the brain, surgical removal or stimulation of the epileptogenic region can be an effective therapy for these patients. The accurate localization of the seizure onset zone (SOZ) is critical for surgical success, but localizing the SOZ often requires implantation of intracranial EEG electrodes and continuous monitoring in the hospital for days to weeks so that seizures are recorded. Despite the longevity and invasiveness of this procedure, surgical success rates can be as low as 34%. In this talk, I will describe a study that aims to improve seizure onset localization and expedite the intracranial monitoring process by employing dynamical network models that investigate the patient’s epileptogenic network with recordings obtained during single-pulse electrical stimulation (SPES). We hypothesize that a dynamical quantification of the connectivity networks derived from the evoked responses induced by SPES could also be used to accurately localize the SOZ and guide clinicians in eliciting native seizures with electrical stimulation. I will give an overview of these dynamical network techniques and describe their potential impact in the clinical treatment of medically-refractory epilepsy.

Bio:

Rachel June Smith is a postdoctoral fellow in the Biomedical Engineering Department and Institute for Computational Medicine at Johns Hopkins University. She received her B.S. in Biomedical Engineering from the University of Tennessee, Knoxville, in 2014 and her M.S. and Ph.D. from UC Irvine in Biomedical Engineering in 2019. Her doctoral work focused on the development of computational metrics in scalp EEG data that reflected disease burden and predicted response to treatment in patients with infantile spasms. Currently, Rachel uses dynamical systems and control theory techniques to localize the onset of seizures in the epileptic brain. Rachel has been recently recognized for her work by the American Epilepsy Society where she won a 2020 Young Investigator Award and was named an AES Fellow.

Zoom Link: https://umich.zoom.us/j/96508834308

Organized by:

Dr. Brendon Baker,
Assistant Professor, Biomedical Engineering

Dr. David Nordsletten,
Associate Professor, Department of Biomedical Engineering and Cardiac Surgery

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Workshop / Seminar Wed, 30 Mar 2022 15:27:55 -0400 2022-04-07T15:30:00-04:00 2022-04-07T16:30:00-04:00 Lurie Biomedical Engineering (formerly ATL) Biomedical Engineering Workshop / Seminar BME 500 Seminar
Chronic Traumatic Encephalopathy (CTE) and the Long-Term Consequences of Sports-Related Repetitive Head Impact Exposure: What We Know Now and What We Need to Know Next (April 7, 2022 4:00pm) https://events.umich.edu/event/93056 93056-21700220@events.umich.edu Event Begins: Thursday, April 7, 2022 4:00pm
Location: Off Campus Location
Organized By: Michigan Concussion Center

Robert Stern, professor of Neurology, Neurosurgery, and Anatomy & Neurobiology and fo-founder and director of Clinical Research at Boston University CTE Center, will present the neuropathological features of chronic traumatic encephalopathy (CTE), including what is currently known about risk factors for developing CTE; the clinical features associated with CTE and the NINDS Consensus Diagnostic Criteria for Traumatic Encephalopathy Syndrome; and the possible fluid and neuroimaging biomarkers for CTE.

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Lecture / Discussion Mon, 07 Mar 2022 08:37:47 -0500 2022-04-07T16:00:00-04:00 2022-04-07T17:00:00-04:00 Off Campus Location Michigan Concussion Center Lecture / Discussion Robert Stern image and title on blue background with blue brain
EEB Thursday Virtual Seminar: Insect evolution, with a focus on Odonata (dragonflies and damselflies) (April 7, 2022 4:00pm) https://events.umich.edu/event/85738 85738-21628577@events.umich.edu Event Begins: Thursday, April 7, 2022 4:00pm
Location: Off Campus Location
Organized By: Ecology and Evolutionary Biology

Our weekly seminar series featuring internal and external speakers in the field of ecology and evolutionary biology.

Abstract
Dragonflies and damselflies, representing the insect order Odonata, are among the earliest flying insects with living (extant) representatives. However, unravelling details of their long evolutionary history, such as egg laying (oviposition) strategies, is impeded by unresolved phylogenetic relationships, an issue particularly prevalent in damselfly families and fossil lineages. Here we present the first transcriptome-based and AHE-based phylogenetic reconstructions of Odonata representing nearly all of the order’s families (except Austropetaliidae and Neopetaliidae). All damselfly families and most dragonfly families are recovered as monophyletic groups. Our Molecular clock estimates suggest that crown-Zygoptera (damselflies) and -Anisoptera (dragonflies) both arose during the late Triassic. Lastly, I briefly will review what we know about population structure in two groups of dragonflies, Neurocordulia and Pantala.

Brief biography
Jessica Ware is an associate curator in invertebrate zoology at the American Museum of Natural History. Dr. Ware’s research focuses on the evolution of behavioral and physiological adaptations in insects, with an emphasis on how these occur in Odonata (dragonflies and damselflies) and Dictyoptera (termites, cockroaches, and mantises). She holds a B.Sc. from the University of British Columbia in Canada, and a Ph.D. from Rutgers, New Brunswick. Ware is the past president of the Worldwide Dragonfly Association and serves as current president of the Entomological Society of America. She was recently awarded a PECASE medal from the U.S. government for her work on insect evolution.

See Zoom link this page

Image: Jessica Ware

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Workshop / Seminar Tue, 05 Apr 2022 09:18:26 -0400 2022-04-07T16:00:00-04:00 2022-04-07T17:00:00-04:00 Off Campus Location Ecology and Evolutionary Biology Workshop / Seminar A dragonfly on a bag of lemons
BioArtography - Call for Images (April 8, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742270@events.umich.edu Event Begins: Friday, April 8, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-08T00:00:00-04:00 2022-04-08T23:59:00-04:00 BioArtography Other U-M BioArtography
17th Annual Early Career Scientists Symposium (April 8, 2022 12:00pm) https://events.umich.edu/event/89659 89659-21664742@events.umich.edu Event Begins: Friday, April 8, 2022 12:00pm
Location: Off Campus Location
Organized By: Ecology and Evolutionary Biology

The Department of Ecology and Evolutionary Biology (EEB) at the University of Michigan presents the 17th Annual Early Career Scientists Symposium: Racial Justice and Anti-Racist Research in EEB. We are delighted to announce that our featured speaker, Steward Pickett, distinguished urban ecologist from the Cary Institute and this year’s eminent ecologist of the Ecological Society of America, will open the symposium. A panel discussion led by Nicholas Reo, Associate Professor of Native American Studies at Dartmouth will bring the symposium to its conclusion.

Eight early career scholars who are transforming our discipline through anti-racist and justice-centered research that pushes our understanding of the links between EEB research and society, will present their perspectives in many areas of EEB, such as Global Environmental Change, Genomics and Population Genetics, Urban Ecology and Evolution, Environmental History, STEM Education, Marine Ecology, Water Security, Theoretical Ecology and Evolution, Global Food Systems, and Disease Ecology. The goal of this symposium is to provide a space for the EEB community to think imaginatively about the future of our discipline.

The symposium will begin on Saturday, March 19, 2022 (2 - 6 pm EDT) in-person and live-streamed, followed by three consecutive virtual Fridays (noon - 2 pm EDT) from March 25– April 8, 2022. Two to three participants will present each Friday, followed by a moderated discussion. For the symposium, we consider early career scientists as senior graduate students (who stand to receive their Ph.D. within two years), postdoctoral researchers, faculty or staff scientists within their first or second year, and researchers at equivalent career stages who are not affiliated with an academic institution.

While the symposium presents the work of rising early career scientists, it is open to all (i.e., you don’t have to be in your early career to attend).

Please contact the planning committee with questions: ecss-2022@umich.edu.

REGISTRATION is required for Zoom entry. You will be provided with the link and passcode upon registration. https://myumi.ch/ECSSregister

SPECIAL THANKS TO COSPONSORS CEW+ (Center for the Education of Women+) Irma M. Wyman Grant Program Fund and the Rackham Faculty Allies Diversity Grant!

Art by John Megahan based on a photo by Nick Reo. Kanaka Maoli and Anishinaabe land and language warriors visit and exchange knowledge at Hale O Kuhio, a structure erected in 2018 to assert the unfulfilled mandate of the Hawaiian Homes Commission Act of 1920.

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Livestream / Virtual Fri, 04 Mar 2022 15:29:01 -0500 2022-04-08T12:00:00-04:00 2022-04-08T14:00:00-04:00 Off Campus Location Ecology and Evolutionary Biology Livestream / Virtual Art by John Megahan based on a photo by Nick Reo. Kanaka Maoli and Anishinaabe land and language warriors visit and exchange knowledge at Hale O Kuhio, a structure erected in 2018 to assert the unfulfilled mandate of the Hawaiian Homes Commission Act of 1920.
MCDB Seminar>CANCELED Shorter Visit CANCELED (April 8, 2022 12:00pm) https://events.umich.edu/event/90418 90418-21670792@events.umich.edu Event Begins: Friday, April 8, 2022 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

This seminar has been canceled.

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Workshop / Seminar Mon, 28 Mar 2022 22:06:54 -0400 2022-04-08T12:00:00-04:00 2022-04-08T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow MCDB initials and microscope cartoon on blue background
BioArtography - Call for Images (April 9, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742271@events.umich.edu Event Begins: Saturday, April 9, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-09T00:00:00-04:00 2022-04-09T23:59:00-04:00 BioArtography Other U-M BioArtography
BioArtography - Call for Images (April 10, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742272@events.umich.edu Event Begins: Sunday, April 10, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-10T00:00:00-04:00 2022-04-10T23:59:00-04:00 BioArtography Other U-M BioArtography
BioArtography - Call for Images (April 11, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742273@events.umich.edu Event Begins: Monday, April 11, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-11T00:00:00-04:00 2022-04-11T23:59:00-04:00 BioArtography Other U-M BioArtography
LSI SciComm Speaker Series: Matt Richtel (April 11, 2022 10:00am) https://events.umich.edu/event/92899 92899-21697950@events.umich.edu Event Begins: Monday, April 11, 2022 10:00am
Location: Palmer Commons
Organized By: Life Sciences Institute (LSI)

* The LSI's SciComm Speaker Series highlights the importance of disseminating scientific findings beyond the walls of the academy and effectively communicating the impact of publicly-funded research. This annual event provides world-leading science writers and communicators with an opportunity to share their experiences with faculty, staff and students, while also tapping into U-M's vast scientific research community. This year's speaker is best-selling author and Pulitzer Prize-winning reporter Matt Richtel.*

In 2019, Richtel's book about the immune system, An Elegant Defense, hit shelves. Richtel steeped the book in deep science, but covered all that deep science in frosting: story, anecdote and humor. When the book came out, the New York Times published an excerpt. What chapter did they choose? The one that asked: Should you pick your nose? Richtel had asked the question as a way of exploring whether our urge to probe our noses is actually a way for evolution to sneak some outside information to our immune systems. While we may not have a definitive answer to that question, after more than two decades at the New York Times and as author of several best-of-the-year science books, Richtel does know the answer to this: How do you make science information palatable? What does it take to educate the public?

There are two answers: One is story. The second is existential crisis. When Covid hit, the public started paying attention to science as never before. But this talk about the former—how to turn science into a story that people are eager to consume and that they will remember.

Over the course of this conversation, Richtel will offer specific examples of how he has married complicated science with compelling stories without sacrificing the sanctity and complexity of the research and scholarship. He will also tackle a number of specific, key issues around the marriage of science and storytelling: ethics, the role of the scientist/scholar, the relationship between scientist and journalist and how to improve it; the responsibility of media to understand how to read science, and accurately calibrate its weight. Plus, all the questions you want to ask!

*Coffee and light refreshments will be offered beginning at 9:30. Richtel will be available to sign books and bookplates immediately following the event.*

About the Speaker:
Matt Richtel is a Pulitzer Prize-winning reporter for The New York Times, lauded speaker and bestselling author. He writes about technology, its impact on society, and how it changes the way we work, play and relate to each other. In 2010 he won the Pulitzer Prize for National Reporting for his series of articles on the hazardous use of cell phones, computers and other devices while driving. Richtel lives in San Francisco with his wife and their two children. He is an avid tennis player, a recreational athlete, a prideful maker of guacamole for parties and a periodic (and not good) songwriter. He grew up in Boulder, Colorado, the son of two avid readers, attended Boulder High School, and obtained a bachelor’s degree in rhetoric from University of California at Berkeley and a master's degree in journalism from Columbia University.

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Lecture / Discussion Tue, 29 Mar 2022 08:05:21 -0400 2022-04-11T10:00:00-04:00 2022-04-11T11:00:00-04:00 Palmer Commons Life Sciences Institute (LSI) Lecture / Discussion LSI SciComm Speaker Series: Matt Richtel, Author and Reporter
Metal Oxo Clusters in Oxidation Chemistry and Water-Splitting Catalysis (April 11, 2022 4:00pm) https://events.umich.edu/event/91343 91343-21678332@events.umich.edu Event Begins: Monday, April 11, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The conversion of solar energy into a useful chemical fuel represents a major scientific goal in the drive towards a society powered by renewable energy. Several potential solar fuels seem possible, including hydrogen from proton reduction, or hydrocarbons from the reduction of carbon dioxide. Useful rates of solar fuel production must rely on an efficient oxidation that generates electrons and protons. In nature's photosynthesis, this is accomplished by a tetra-manganese oxo cluster (the oxygen-evolving complex, OEC), which yields 4 protons and 4 electrons by the photo-oxidation of water (the oxygen evolution reaction, OER). For solar fuel applications this water-splitting half reaction must be catalyzed to make it energetically feasible, and transition-metal oxo cubane clusters related to the OEC represent intriguing model systems and design motifs for new water-splitting catalysts based on abundant metals. Molecularly derived catalysts of this type offer potential advantages, including the synthetic tunability of catalytic and chemical properties. In addition, the study of high-valent molecular species can provide key insights into the mechanism of water oxidation and help bridge the gap between solid-state and molecular systems to allow for more rational design of catalysts. This presentation will describe high-valent metal complexes and clusters, and a detailed mechanism for the evolution of oxygen via water oxidation at a tetranuclear cobalt oxo cubane. An important aspect to this catalysis relates to the manner in which metals cooperate to mediate multi-electron, multi-proton oxidations. In further pursuit of these concepts, the synthesis and study of related heterometallic oxo clusters have been targeted.

Don Tilley (University of Caifornia, Berkeley)

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Other Mon, 11 Apr 2022 18:15:26 -0400 2022-04-11T16:00:00-04:00 2022-04-11T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
RNA Innovation Seminar: "Alternative structures of the SARS-CoV-2 RNA genome control gene expression and offer therapeutic strategies" (April 11, 2022 4:00pm) https://events.umich.edu/event/92832 92832-21697177@events.umich.edu Event Begins: Monday, April 11, 2022 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

VIrtual Seminar: https://umich.zoom.us/webinar/register/WN_zi3UlKucR6G51hEA_33Exg

If you are having trouble registering, please contact Martina Jerant at mjerant@umich.edu

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Lecture / Discussion Fri, 01 Apr 2022 17:40:01 -0400 2022-04-11T16:00:00-04:00 2022-04-11T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Silvi Rouskin, Ph.D., Harvard Medical School
BioArtography - Call for Images (April 12, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742274@events.umich.edu Event Begins: Tuesday, April 12, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-12T00:00:00-04:00 2022-04-12T23:59:00-04:00 BioArtography Other U-M BioArtography
Nickel-Mediated Radical Pathways and Applications to Peptide Modification (April 12, 2022 11:00am) https://events.umich.edu/event/94329 94329-21734377@events.umich.edu Event Begins: Tuesday, April 12, 2022 11:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Reactions involving organic radical intermediates have been traditionally regarded as overly reactive and unselective. Nickel complexes can mediate reactions involving radicals by forming metallo-radical intermediates, and thus modulate the reactivity and control the selectivity. We apply organometallic and physical organic techniques to characterize fundamental steps involved in nickel-catalyzed cross-coupling reactions, including radical generation, chain propagation, termination, and C–C bond formation. Mechanistic insight has informed us in the development of an enantioselective method to modify peptides. The reaction provides a convenient means to access non-canonical peptides that could serve as pharmaceutical targets.
Tianning Diao (New York University)

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Other Tue, 12 Apr 2022 18:15:17 -0400 2022-04-12T11:00:00-04:00 2022-04-12T12:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
A Detailed Look at Tail-Anchored Membrane Protein Targeting-From Opisthokonts to Protists to Plans- Department of Biological Chemistry Martha Ludwig Lectureship (April 12, 2022 12:00pm) https://events.umich.edu/event/92445 92445-21691563@events.umich.edu Event Begins: Tuesday, April 12, 2022 12:00pm
Location: Medical Science Unit I
Organized By: Biological Chemistry

Dr. Bil Clemons will give an in person seminar on Tuesday 4/12/2022 at 12:00 noon in 5330 MS I.

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Workshop / Seminar Wed, 16 Feb 2022 12:55:15 -0500 2022-04-12T12:00:00-04:00 2022-04-12T13:00:00-04:00 Medical Science Unit I Biological Chemistry Workshop / Seminar Clemons
“How your cilia communicate intercellular signaling?" (April 12, 2022 4:00pm) https://events.umich.edu/event/90536 90536-21671501@events.umich.edu Event Begins: Tuesday, April 12, 2022 4:00pm
Location: Off Campus Location
Organized By: Center for Cell Plasticity and Organ Design

The Center for Cell Plasticity and Organ Design is proud to present the following seminar speaker:
Jeremy Reiter, MD, PhD
Professor & Chair, Department of Biochemistry and Biophysics
University of California, San Francisco


The talk is entitled, “How your cilia communicate intercellular signaling."

Public Seminar: 4-5 p.m. Zoom: https://umich.zoom.us/j/98790098902

Faculty Host: Sunny Wong, PhD, Department of Dermatology

For more info email: Organogenesis@umich.edu

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Lecture / Discussion Thu, 24 Mar 2022 16:20:19 -0400 2022-04-12T16:00:00-04:00 2022-04-12T17:00:00-04:00 Off Campus Location Center for Cell Plasticity and Organ Design Lecture / Discussion JR Flyer
Capture and Release of Metals of Energy Importance Using Redox-Switchable Carboranes (April 12, 2022 4:00pm) https://events.umich.edu/event/90378 90378-21670539@events.umich.edu Event Begins: Tuesday, April 12, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Inorganic
Gabriel Menard (UC Santa Barbara)

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Other Tue, 12 Apr 2022 18:15:17 -0400 2022-04-12T16:00:00-04:00 2022-04-12T17:15:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Functional MRI 2021-22 Speaker Series with Katharine Thakkar, Ph.D. (April 12, 2022 4:00pm) https://events.umich.edu/event/93931 93931-21710805@events.umich.edu Event Begins: Tuesday, April 12, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Functional MRI Lab

Abstract:

The ability to make rapid behavioral adjustments is critical in a dynamic environment, and impaired action control is associated with several neuropsychiatric disorders, including schizophrenia. Rapid action modification and cancellation has been investigated using the stop-signal task and related paradigms. These paradigms require a fast response to a movement cue unless a subsequent signal is presented that instructs participants to inhibit or change the planned movement. Performance on these tasks is modeled as a race between competing STOP and GO processes, which permits an estimation of the time it takes to stop a prepared action—stop-signal reaction time. Using oculomotor versions of such tasks, nonhuman primate studies have investigated the cellular basis of reactive action control and performance monitoring. This body of neurophysiology work provides a firm basis from which to understand the brain circuits supporting reactive action control in humans. In this talk, I will present work that uses fMRI to examine the network involved in rapid cancellation, modification, and monitoring of gaze in humans. In addition, I will present a series of studies indicating reduced efficiency of action cancellation in individuals with schizophrenia that are related to symptoms and functional outcomes and more recent work demonstrating altered activation in a frontobasal network in individuals with schizophrenia while performing a modified oculomotor stop-signal task. Combined, this work provides a link between mechanisms of action control in humans and non-human primates and insights into potential mechanisms of inefficient action control in individuals with schizophrenia.

You can attend in person: 4 p.m. Chemistry & Dow Willard H Laboratory (Central Campus), Room 1300.

You can attend via Zoom: https://umich.zoom.us/j/91394388153,
passcode: 892467

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Lecture / Discussion Thu, 24 Mar 2022 07:28:12 -0400 2022-04-12T16:00:00-04:00 2022-04-12T17:30:00-04:00 Chemistry Dow Lab Functional MRI Lab Lecture / Discussion Katharine Thakkar, Ph.D.
BioArtography - Call for Images (April 13, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742275@events.umich.edu Event Begins: Wednesday, April 13, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-13T00:00:00-04:00 2022-04-13T23:59:00-04:00 BioArtography Other U-M BioArtography
New insights into the regulation of energy homeostasis (April 13, 2022 9:30am) https://events.umich.edu/event/92909 92909-21698063@events.umich.edu Event Begins: Wednesday, April 13, 2022 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

CDB 2022 Seminar Series:

We are pleased to welcome Alan Robert Saltiel, Ph.D. to the Kahn Auditorium in BSRB on April 13, 2022, to present his talk titled "New insights into the regulation of energy homeostasis"!

In-Person & Virtual
Zoom Meeting link: https://umich.zoom.us/j/97387165812

Hosted By:
Doug Engel, Ph.D. Cell and Developmental Biology
Scott Soleimanpour, M.D., Caswell Diabetes Institute (CDI)

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Lecture / Discussion Fri, 11 Mar 2022 12:15:06 -0500 2022-04-13T09:30:00-04:00 2022-04-13T10:30:00-04:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion New insights into the regulation of energy homeostasis
UM/Agilent Measurement Symposium (April 13, 2022 5:00pm) https://events.umich.edu/event/85162 85162-21625673@events.umich.edu Event Begins: Wednesday, April 13, 2022 5:00pm
Location: Off Campus Location
Organized By: Department of Chemistry

Analytical

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Other Mon, 21 Mar 2022 12:15:27 -0400 2022-04-13T17:00:00-04:00 2022-04-13T20:45:00-04:00 Off Campus Location Department of Chemistry Other
BioArtography - Call for Images (April 14, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742276@events.umich.edu Event Begins: Thursday, April 14, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-14T00:00:00-04:00 2022-04-14T23:59:00-04:00 BioArtography Other U-M BioArtography
UM Agilent Measurement Symposium (April 14, 2022 9:00am) https://events.umich.edu/event/85072 85072-21625546@events.umich.edu Event Begins: Thursday, April 14, 2022 9:00am
Location: Weiser Hall
Organized By: Department of Chemistry

Analytical
David Russell(TAMU) , Susan Olesik(Ohio State University) , John Fjeldsted(Agilent) , Darlene Solomon(Agilent)

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Other Thu, 14 Apr 2022 18:15:24 -0400 2022-04-14T09:00:00-04:00 2022-04-14T17:00:00-04:00 Weiser Hall Department of Chemistry Other Weiser Hall
Cellular Mechanisms of Lip and Primary Palate Fusion (April 14, 2022 12:00pm) https://events.umich.edu/event/94366 94366-21735840@events.umich.edu Event Begins: Thursday, April 14, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

A. Personal Statement

Highlighted publications:

Lewis A.E., Kuwahara A., Franzosi J., Bush, J.O.* (2022) Tracheal separation is driven by NKX2-1-mediated repression of Efnb2 and regulation of endodermal cell sorting. Cell Reports, 38(11):110510

Kindberg A.A., Srivastava, V., Muncie, J.M., Weaver V.M., Gartner, Z.J. and Bush, J.O.* (2021). EPH/EPHRIN regulates cellular organization by actomyosin contractility effects on cell contacts Journal of Cell Biology 220 (6): e202005216 PMCID: PMC8025214

Kuwahara, A., Lewis, A., Coombes, C., Leung, F.S., Percharde M., Bush J.O.* (2020) Delineating the early transcriptional specification of the mammalian trachea and esophagus. eLife, 9:e55526 PMCID: PMC7282815

Niethamer, T. K., Teng, T., Franco, M., Du, Y. X., Percival, C. J., Bush, J.O.* (2020). Aberrant cell segregation in the craniofacial primordium and the emergence of facial dysmorphology in craniofrontonasal syndrome. PLoS Genet. 16, e1008300.

Highlighted projects:
R35 DE031926-01 (PI: Bush) 4/1/2022-3/31/2030
NIH/NIDCR
Signaling control and cellular basis of craniofacial morphogenesis and congenital disease

R01 DE023337 (PI: Bush) 7/9/2013-3/31/2022
NIH/NIDCR
Mechanisms of Eph/Ephrin signaling in craniofacial morphogenesis and craniofrontonasal syndrome

R01DE028753 (PI: Selleri) 4/1/2019-3/31/2024
NIH/NIDCR
Phenotype-driven approach to understanding the function of craniofacial regulators using IMPC-generated mouse strains

UG3DE028872 (PI: Klein) 7/1/2019-6/30/2024
NIH/NIDCR
“Enamel atlas: systems-level amelogenesis tools at multiple scales”

B. Positions, Scientific Appointments and Honors
Positions and Employment:
2019-present Vice Chair, Department of Cell and Tissue Biology
2021-present Professor, Department of Cell and Tissue Biology and Program in Craniofacial Biology, University of California at San Francisco
2017-2021 Associate Professor, Department of Cell and Tissue Biology and Program in Craniofacial
Biology, University of California at San Francisco
2011-2017 Assistant Professor, Department of Cell and Tissue Biology and Program in
Craniofacial Biology, University of California at San Francisco
2005-2011 Postdoctoral research at FHCRC/MSSM
Advisor: Dr. Philippe Soriano
1999-2005 Graduate and postdoctoral research at University of Rochester
Advisor: Dr. Rulang Jiang

Awards and Honors:
2021 Marylou Buyse Distinguished Scientist in Craniofacial Research award from the Society for Craniofacial Genetics and Developmental Biology
2019 F1000 Faculty member for Developmental Biology
2019 David W. Smith workshop on malformations and morphogenesis keynote
2014 American Association of Anatomists Young Faculty Travel Award
2010-present F1000/F1000Prime has featured and highly ranked five of our publications
2010 NIH pathway to independence award from NIH/NIDCR K99/R00 (DE020855)
2006-2008 Ruth L Kirschstein NRSA Individual Fellowship from NIH/NIDCR F32 (DE17506)
2005 Basil Bibby award from the AADR
2004 Michael G. Buonocore award from the AADR

Other Experience and Professional Memberships
2021-2025 Member NIH Skeletal Biology Development and Disease (SBDD)
2021 Cold Spring Harbor Labs Mouse Engineering Course lecturer and workshop leader
2021 American Association of Anatomists Program Committee
2020 Ad hoc reviewer NIH/NIDCR SEP ZDE1 Endogenous Regeneration of Dental, Oral and Craniofacial Tissue
2020 Ad hoc reviewer NIH CSR ZRG1 Fellowships: Cell Biology, Developmental Biology and Bioengineering
2020 Ad hoc reviewer Czech Science Foundation
2019 Ad hoc reviewer for NIH Skeletal Biology Development and Disease (SBDD)
2017 Ad hoc reviewer for NIH on Microphysiological Systems (MPS) for Disease Modeling and Efficacy Testing (UG3/UH3) “Tissue Chips and Disease Modeling”
2017-present International Association for Dental Research
2017 Guest Editor, Developmental Biology, special issue on signaling in development
2014 Ad hoc reviewer for NIH on SEP ZRG1 MOSS-D (02), “Bone, Cartilage and Tendon”
2013, 2014 Invited peer reviewer for UK MRC
2012 Ad hoc reviewer for NIH on Council ZES1, “Environmental influences on stem cells in development, health and disease”
2012 Organizer, session chair, Society of Craniofacial Genetics Annual Meeting, San Francisco, CA
2012-present Member, Society for Craniofacial Genetics and Development
2010-present Member, American Association of Anatomists
2000-present Member, Society for Developmental Biology
Ad hoc Reviewer for Development, Developmental Biology, Developmental Dynamics, Journal of Dental Research, Genesis, Immunobiology, Journal of Cell Biology, Science, PLOS Genetics, Immunobiology, PLOS One, Developmental Cell, PLOS Biology, Human Molecular Genetics, JOVE

C. Contributions to Science
1. Identified Eph/ephrin cellular mechanisms in morphogenesis
We have made major contributions to understanding EPH/EPHRIN signaling mechanisms in development in multiple contexts including the craniofacial, neural and neural crest systems. The EPHs compose the largest family of receptor tyrosine kinases in the vertebrate genome constituting one quarter of the total number. Though extensively studied in the nervous system, the signaling mechanisms utilized by this family in other contexts are complex and modestly understood, particularly in vivo. We have learned that a large number of these molecules exhibit distinct expression patterns in the developing craniofacial region. In a novel “conditional-rescue” approach we discovered that EPHRIN-B2 is required in the vascular endothelium for normal NCC development. EPH/EPHRIN signaling is widely known to regulate cellular organization, but the signaling mechanisms by which it does so are unclear. By studying a series of targeted and signaling mutations in EPHRIN-B1 and its receptors EPHB2 and EPHB3 in mice, we determined that EPH/EPHRIN cell segregation involves unidirectional forward signaling from EPHRIN-B1 and relies on kinase activity of the receptors. By live cell imaging we also observe that this unidirectional signaling results in changes in cortical actomyosin accumulation and leading us to interrogate the biophysical basis for EPH/EPHRIN cell segregation. We recently discovered that EPH/EPHRIN signaling modulates the strength of cell-cell contacts by regulating cell interfacial tension through increased heterotypic cortical actomyosin contractility. The minimization of heterotypic interfacial tension also informs how EPH/EPHRIN signaling regulates tissue shape changes relevant to Contributions number 2 and 4. Current efforts in this area focus on how EPH/EPHRIN signaling regulates mesenchymal cell polarity and cell position, forming the basis for part of “Focus one” of this proposal.

Agrawal, P., Wang, M., Kim, S., Lewis, A.E., Bush, J.O.* (2014) The embryonic expression of EphA receptor genes in mice supports their candidacy for involvement in cleft lip and palate. Developmental Dynamics, 243 (11): 1470-6. PMCID: PMC4404412
Lewis, A.E., Hwa, J., Wang, R., Soriano P., Bush, J.O.* (2015) Neural crest defects in ephrin-B2 mutant mice are non-autonomous and originate from defects in the vasculature. Developmental Biology, 406(2): 186-95. PMCID: PMC4639416
O’Neill, A.O., Kindberg, A.A., Niethamer, T.K. Larson, A.R., Ho, H.H., Greenberg, M.E., Bush, J.O.* (2016) Unidirectional Eph/ephrin signaling creates a cortical actomyosin differential to drive cell segregation. Journal of Cell Biology, 215 (2): 217 PMCID: PMC5984648
Kindberg A.A., Srivastava, V., Muncie, J.M., Weaver V.M., Gartner, Z.J. and Bush, J.O.* (2021). EPH/EPHRIN regulates cellular organization by actomyosin contractility effects on cell contacts Journal of Cell Biology 220 (6): e202005216 PMCID: PMC8025214

2. Delineated Eph/ephrin signaling mechanisms underlying craniofrontonasal syndrome
We have focused on the role of EPH/EPHRIN signaling in craniofrontonasal syndrome (CFNS), an X-linked condition caused by mutations in EFNB1 characterized by hypertelorism, craniosynostosis, cleft lip and palate, agenesis of the corpus callosum, and particularly increased severity in female patients. By generating a series of signaling mutations in three different gene targeted mouse lines, we were able to determine the relevant modes of signaling for different EPHRIN-B1 phenotypes. We found that reverse signaling by a PDZ-dependent mechanism is critical for axon guidance, whereas it is dispensible for skeletal and craniofacial development. This work showed that different aspects of craniofrontonasal syndrome are caused by loss of function of distinct molecular EPHRIN-B1 signaling functions. Further, by integrating mouse genetics, phosphoproteomic and transcriptomic approaches we have investigated downstream signaling pathways utilized by EPHRIN-B1 in craniofacial development and disease. In this context, we were the first to show that EPH receptor expression is regulated by endocytosis in vivo, and that EPHRIN-B1 controls cell proliferation by the Ras/MAPK signaling pathway. We have also generated an hiPSC model for CFNS, which to our knowledge is the first hiPSC model of a congenital craniofacial syndrome, and used to it ask key questions about the cellular etiology underlying this perplexing disease. Recently, we coupled geometric morphometric techniques with temporal and spatial manipulation of EPHRIN-B1 signaling to elucidate how Efnb1 mutations result in stereotyped dysmorphology in CFNS. Current efforts in this area focus on delineating the proximal signal transduction mechanisms employed by EPH/EPHRIN-B1 signaling in craniofacial morphogenesis using CRISPR/CAS9 based methods.

Bush, J. O. and Soriano, P. (2010). Ephrin-B1 forward signaling regulates craniofacial morphogenesis by controlling cell proliferation across Eph-ephrin boundaries. Genes Dev. 24, 2048-60. PMCID: PMC2939368
Niethamer, T.K., Larson, A.R., O’Neill A.K., Bershteyn, M., Hsiao, E.C., Klein, O.D., Pomerantz, J.H., Bush J.O.* (2017) EPHRIN-B1 mosaicism drives cell segregation in craniofrontonasal syndrome hiPSC-derived neuroepithelial cells. Stem Cell Reports, 8(3): 529-537. PMCID: PMC5355632
Niethamer, T. K. and Bush, J. O.* (2019). Getting direction(s): The Eph/ephrin signaling system in cell positioning. Dev. Biol. 447, 42–57.
Niethamer, T. K., Teng, T., Franco, M., Du, Y. X., Percival, C. J., Bush, J. O. (2020). Aberrant cell segregation in the craniofacial primordium and the emergence of facial dysmorphology in craniofrontonasal syndrome. PLoS Genet. 16, e1008300.

3. Developed live imaging approaches to discover cellular mechanisms of craniofacial tissue fusions
Though tissue fusion is a critical final step of lip and palate development, we currently lack cellular resolution understanding of how these tissue fusion events occur, and how they are controlled. We have been examining the cellular and molecular mechanisms by which tissue fusion occurs by combining live imaging of mouse morphogenesis with mouse genetic and physical perturbations. We developed the first successful application of confocal live imaging technology to secondary palate development, and it has allowed us to make new discoveries on the cellular mechanisms at play. Our results indicate that tissue fusion proceeds by a progression of dynamic cell behaviors beginning with convergence of two independent epithelia and concomitant to orthogonal displacement of the resultant shared epithelium. Further, we have found that epithelial cell extrusion, in which cells are squeezed out of an epithelium, is a novel contributor to the removal of the midline epithelial seam (MES). A nearly completed manuscript presents a new live imaging approach to understanding secondary palate fusion, and demonstrates a unique and novel form of collective epithelial migration that is crucial for this process. Most recently, we have also established live imaging approaches for the study of upper lip/primary palate fusion, which we are using to study roles for actomyosin contractility and cell adhesion in this process.

Bush J.O.*, Jiang R.* (2012) Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development. Development. 139(2):231-43. PMCID: PMC3243091
Kim, S., Lewis A.E., Singh V., Ma, X., Adelstein, R., Bush, J.O.,* (2015) Convergence and extrusion are required for normal fusion of the mammalian secondary palate. PLOS Biology, 13(4) PMCID: 4388528
Kim S., Prochazka, J., Bush J.O.*, (2017) Live imaging of Mouse Secondary Palate Fusion. JoVE. July 2017 (125) PMCID: In process

4. Improved mouse genetics tools for the study of craniofacial and neural crest development and disease
In the course of our studies, we discovered that the Wnt1-Cre mouse line exhibits developmental phenotypes attributable to elevated and ectopic activation of Wnt signaling. This is a standard and widely used reagent in the fields of craniofacial development and neural crest stem cell biology and our careful analysis of this reagent has already had broad-reaching effects causing labs to re-examine previously published work. To provide a reagent that is devoid of these complications, we generated a Wnt1-Cre2 transgenic mouse line that exhibits the same pattern of activity as Wnt1-Cre but does not cause ectopic activation of Wnt signaling or developmental phenotypes. Over the past five years, I have also served as the faculty advisor for the UCSF mouse inventory database, which facilitates the sharing of genetically modified mouse lines. Most recently, my lab has successfully adopted the iGONAD electroporation method for rapid generation of new mouse lines which we are employing to generate new mouse models for the study of congenital disease.

Lewis, A., Vasudevan, H., O’Neill, A., Soriano, P., Bush, J.O.* (2013) The widely used Wnt1-Cre transgene causes developmental phenotypes by ectopic activation of Wnt signaling. Developmental Biology, 379(2):229-34. PMCID: PMC3804302
Wall, E., Scoles, J., Joo, A., Klein, O., Quinonez, C., Bush, J. O., Martin, G. R. and Laird, D. J. (2020). The UCSF Mouse Inventory Database Application, an Open-Source Web App for Sharing Mutant Mice within a Research Community. G3 (Bethesda).

5. Understanding how cell fate and morphogenesis are coupled in the developing foregut
Based initially on phenotypes that we discovered in an Efnb2 mutant mouse line that we generated, we have now established a robust research focus on understanding the specification and morphogenesis of the trachea and esophagus. Classical developmental biology experiments hypothesize that two transcription factors, NKX2.1 and SOX2 act as master regulators of these fates, but this remains untested at the transcriptome level and their targets were unknown. we combine state-of-the-art transcriptomic experiments in embryonic tissues with functional mouse genetic experiments to expose the fundamental process of fate specification of the trachea and esophagus. We performed single cell RNA sequencing in mice to establish a transcriptome-wide understanding of the early steps of trachea and esophagus development and used these data, combined with RNA-sequencing of mutants and embryonic ChIP-seq to interrogate the transcriptome-wide function of NKX2.1 in tracheal and esophageal development. The results of these experiments provide a new understanding of how the trachea and esophagus are initially specified at the genome-wide level. Our studies also reveal that NKX2.1 directly represses Efnb2 to regulate the site of tracheoesophageal separation. These discoveries may be impactful to the study of tracheal, lung, and esophageal developmental biology and related structural anomalies in humans, as well as for the fields of embryonic stem cell biology and for lung and esophageal cancer for which these are keystone transcriptional pathways.

Kuwahara, A., Lewis, A., Coombes, C., Leung, F.S., Percharde M., Bush J.O.* (2020) Delineating the early transcriptional specification of the mammalian trachea and esophagus. eLife, 9:e55526 PMCID: PMC7282815
Lewis A.E., Kuwahara A., Franzosi J., Bush, J.O.* (2022) Tracheal separation is driven by NKX2-1-mediated repression of Efnb2 and regulation of endodermal cell sorting. Cell Reports, 38(11):110510

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Lecture / Discussion Tue, 05 Apr 2022 10:39:07 -0400 2022-04-14T12:00:00-04:00 2022-04-14T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Lecture / Discussion Jeffrey Bush Professor and Vice Chair, Department of Cell and Tissue Biology and Program in Craniofacial Biology
DCM&B Tools and Technology Seminar (April 14, 2022 12:00pm) https://events.umich.edu/event/89814 89814-21665892@events.umich.edu Event Begins: Thursday, April 14, 2022 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

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Presentation Fri, 25 Mar 2022 10:41:08 -0400 2022-04-14T12:00:00-04:00 2022-04-14T13:00:00-04:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
EEB Thursday Seminar: How (and why) to get a tenure-track job at a non research-1 university (April 14, 2022 4:00pm) https://events.umich.edu/event/86330 86330-21632730@events.umich.edu Event Begins: Thursday, April 14, 2022 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Our weekly seminar series featuring internal and external speakers in the field of ecology and evolutionary biology. This seminar will be in-person and livestreaming on Zoom (link this page).

Abstract
Many Ph.D. students and postdocs at Research-1 (R1) universities are interested in exploring academic careers at non-academic universities, including liberal arts colleges and master's-granting universities. However, resources on how to prepare to be competitive in applications for job openings may be scarce at R1 universities because advising faculty are most familiar with preparation for applying for R1 jobs. I am a professor of biological sciences at a public, master's-granting institution where I have served on numerous tenure-track faculty search committees over the past 18 years. In this presentation, I give attendees practical advice on how to prepare to apply for tenure-track jobs at non-R1 universities, including important experience they should have, how to write the cover letter, teaching statement, research statement, and diversity statement, and advice for phone and on-campus interviews. Though the talk is geared toward graduate students and postdocs, faculty are welcome to attend so that they can better advise students interested in non-R1 jobs.

Image credit: Brittany App

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Workshop / Seminar Wed, 13 Apr 2022 15:45:55 -0400 2022-04-14T16:00:00-04:00 2022-04-14T17:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Emily Taylor showing students a snake on a class field trip
Shaomeng Wang Drug Discovery Award Lecture (April 14, 2022 4:00pm) https://events.umich.edu/event/94455 94455-21739821@events.umich.edu Event Begins: Thursday, April 14, 2022 4:00pm
Location: Palmer Commons
Organized By: U-M College of Pharmacy

The Univeristy of Michigan College of Pharmacy is pleased to announce the first Shaomeng Wang Drug Discovery Award Lecture: “Chemical Strategies for Drugging the Undruggable, from KRAS to p53,” presented by Kevan M. Shokat, PhD, Professor, Department of Cellular and Molecular Pharmacology, UCSF; Professor, Department of Chemistry, UC Berkeley; Investigator, Howard Hughes Medical Institute.

Kevan M. Shokat received his B.A. in Chemistry from Reed College in 1986, his Ph.D. in organic chemistry at UC Berkeley with Professor Peter Schultz and carried out post-doctoral work in cellular immunology at Stanford University with Professor Chris Goodnow. Kevan’s research group is focused on the discovery of new small molecule tools and drug candidates targeting protein/lipid kinases, GTPases, and RNA helicases. His laboratory utilizes the tools of synthetic organic chemistry, protein engineering, structural biology, biochemistry and cell biology. He was inducted into the National Academy of Sciences (2010), the National Academy of Medicine (2011), and the American Academy of Arts and Sciences (2011). He has commercialized discoveries from his laboratory through co-founding several biotechnology companies including Intellikine, Araxes, Wellspring Biosciences, Kura Oncology, eFFECTOR Therapeutics, Mitokinin, Revolution Medicines, Erasca and Kumquat Biosciences.

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Lecture / Discussion Thu, 07 Apr 2022 09:02:06 -0400 2022-04-14T16:00:00-04:00 2022-04-14T17:00:00-04:00 Palmer Commons U-M College of Pharmacy Lecture / Discussion Shaomeng Wang Drug Discovery Award Lecture
BioArtography - Call for Images (April 15, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742277@events.umich.edu Event Begins: Friday, April 15, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-15T00:00:00-04:00 2022-04-15T23:59:00-04:00 BioArtography Other U-M BioArtography
U-M Structure Seminar: "Size doesn't matter: de novo generation of llama-derived nanobodies for biological research" (April 15, 2022 10:00am) https://events.umich.edu/event/90345 90345-21670437@events.umich.edu Event Begins: Friday, April 15, 2022 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

Matthias Truttman, Ph.D.
Assistant Professor, Department of Molecular & Integrative Physiology
University of Michigan

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Livestream / Virtual Wed, 23 Mar 2022 10:41:54 -0400 2022-04-15T10:00:00-04:00 2022-04-15T11:00:00-04:00 Life Sciences Institute U-M Structural Biology Livestream / Virtual structure
MCDB Seminar> Long-term imaging of cortical and spinal cord pain processing in the awake, behaving mouse (April 15, 2022 12:00pm) https://events.umich.edu/event/90432 90432-21670808@events.umich.edu Event Begins: Friday, April 15, 2022 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Bo Duan

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Workshop / Seminar Mon, 11 Apr 2022 13:01:40 -0400 2022-04-15T12:00:00-04:00 2022-04-15T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow MCDB initials and microscope cartoon on blue background
BIBC Research Seminar (April 15, 2022 4:00pm) https://events.umich.edu/event/93656 93656-21707957@events.umich.edu Event Begins: Friday, April 15, 2022 4:00pm
Location: Off Campus Location
Organized By: BioInnovations in Brain Cancer

The BIBC seminars will showcase the multidisciplinary research of faculty studying brain cancer biology and novel technologies that can be used for brain cancer diagnosis and treatment.

Please join us on Friday, April 15, 4-5pm to hear from Dr. Michelle Kim and Dr. Aki Morikawa on their work in developing advanced imaging for glioblastoma and systemic therapeutic options for CNS metastasis. This meeting will be held over a Zoom Webinar using the link and passcode below.

Zoom link: https://umich.zoom.us/j/94080044960
Passcode: 106863

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Livestream / Virtual Mon, 21 Mar 2022 09:24:01 -0400 2022-04-15T16:00:00-04:00 2022-04-15T17:00:00-04:00 Off Campus Location BioInnovations in Brain Cancer Livestream / Virtual
BioArtography - Call for Images (April 16, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742278@events.umich.edu Event Begins: Saturday, April 16, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-16T00:00:00-04:00 2022-04-16T23:59:00-04:00 BioArtography Other U-M BioArtography
BioArtography - Call for Images (April 17, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742279@events.umich.edu Event Begins: Sunday, April 17, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-17T00:00:00-04:00 2022-04-17T23:59:00-04:00 BioArtography Other U-M BioArtography
BioArtography - Call for Images (April 18, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742280@events.umich.edu Event Begins: Monday, April 18, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-18T00:00:00-04:00 2022-04-18T23:59:00-04:00 BioArtography Other U-M BioArtography
RNA Innovation Seminar: "Signaling Pathway Variation and Evolutionary Hotspots in the Fungi" (April 18, 2022 12:00pm) https://events.umich.edu/event/92834 92834-21697178@events.umich.edu Event Begins: Monday, April 18, 2022 12:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

In-person/Hybrid seminar
Zoom: https://umich.zoom.us/webinar/register/WN_7wk1SlRdQ_e04VnwcjVV7g

Talk title: “Signaling Pathway Variation and Evolutionary Hotspots in the Fungi"

Keywords:
population genomics, statistical genetics, gene networks, microbial pathogenesis

Abstract:
Evolutionarily conserved signal transduction pathways, such as Ras-cAMP-PKA, calcineurin, and TOR signaling, are primary regulators of stress responses and morphogenetic processes across the fungal tree of life. From an evolutionary perspective, these pathways are expected to be under relatively strong stabilizing selection, as loss-of-function mutations (LoF) in these pathways typically lead to reduced growth rates and increased sensitivity to environmental stresses. We have carried out comparative population genomic analyses of signaling pathway LoF alleles for multiple fungal species, and find that several pathways exhibit unusually high frequencies of naturally occurring putative LoF alleles. We discuss the implications of this finding for the evolutionary lability of signaling pathways in the fungi, and combine information on loss-of-function alleles with related evidence from QTL mapping and experimental evolution studies to identify pathways that may act as "evolutionary hotspots" for adaptation to novel environments.

If you are having trouble registering, please contact Martina Jerant at mjerant@umich.edu

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Lecture / Discussion Mon, 18 Apr 2022 10:56:03 -0400 2022-04-18T12:00:00-04:00 2022-04-18T13:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion Paul Magwene, Ph.D., Duke University
The Promise of Inclusivity in Biosocial Research - Lessons from Population-based Studies (April 18, 2022 12:00pm) https://events.umich.edu/event/92210 92210-21688190@events.umich.edu Event Begins: Monday, April 18, 2022 12:00pm
Location: Off Campus Location
Organized By: Institute for Social Research

Inclusive Research Matters Series
The Promise of Inclusivity in Biosocial Research - Lessons from Population-based Studies
April 18, 2022, noon ET via Zoom

Speakers:
- Jessica Faul, Research Associate Professor, SRC, Institute for Social Research
- Colter Mitchell, Research Associate Professor, SRC, Institute for Social Research

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Lecture / Discussion Thu, 10 Feb 2022 14:42:54 -0500 2022-04-18T12:00:00-04:00 2022-04-18T13:10:00-04:00 Off Campus Location Institute for Social Research Lecture / Discussion flyer
Viral Noncoding RNAs: New Insights into RNA Structure (April 18, 2022 4:00pm) https://events.umich.edu/event/86654 86654-21635378@events.umich.edu Event Begins: Monday, April 18, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Chembio
Joan Steitz (Yale University School of Medicine)

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Other Mon, 18 Apr 2022 18:15:10 -0400 2022-04-18T16:00:00-04:00 2022-04-18T17:15:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
BioArtography - Call for Images (April 19, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742281@events.umich.edu Event Begins: Tuesday, April 19, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-19T00:00:00-04:00 2022-04-19T23:59:00-04:00 BioArtography Other U-M BioArtography
LHS Collaboratory (April 19, 2022 11:00am) https://events.umich.edu/event/93101 93101-21700618@events.umich.edu Event Begins: Tuesday, April 19, 2022 11:00am
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Presentation 1:
Medical AI - Three Common Myths on the Path from Code to Clinic
Alan Karthikesalingam, MD, PhD
Research Lead, Google Health UK at Google

In this talk, Alan Karthikesalingam will discuss lessons learned in Google's experiences of taking medical AI systems from early research to clinical implementation.

Presentation 2:
Medical AI - Raising the Bar on Evidence Standards
Xiao Liu, MBChB, PhD(link is external)
Ophthalmologist and Clinical Researcher
University Hospitals Birmingham NHS Foundation Trust University of Birmingham, UK

In this talk, Xiao Liu will discuss existing and new clinical evidence standards as applied to medical AI systems. Her talk will focus on recently published standards to ensure transparency and reproducibility of clinical evidence underpinning medical AI systems, including reporting guidelines such as SPIRIT-AI and CONSORT-AI.

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Lecture / Discussion Tue, 08 Mar 2022 00:04:28 -0500 2022-04-19T11:00:00-04:00 2022-04-19T12:30:00-04:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion Collaboratory logo
The ISG15 Ubiquitin-like Protein in Innate immune Signaling- Department of Biological Chemistry Distinguished Alumni Lecture (April 19, 2022 12:00pm) https://events.umich.edu/event/92446 92446-21691564@events.umich.edu Event Begins: Tuesday, April 19, 2022 12:00pm
Location: Medical Science Unit I
Organized By: Biological Chemistry

Dr. Huibregtse will present an in person lecture on Tuesday 4/19/2022 in room 5330 MS I at 12pm

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Workshop / Seminar Wed, 16 Feb 2022 12:54:09 -0500 2022-04-19T12:00:00-04:00 2022-04-19T13:00:00-04:00 Medical Science Unit I Biological Chemistry Workshop / Seminar Jon Huibregtse
Life, Death and Transformation in the Transition Zone: an Emerging Model of Endochondral Ossification (April 19, 2022 4:00pm) https://events.umich.edu/event/91157 91157-21677016@events.umich.edu Event Begins: Tuesday, April 19, 2022 4:00pm
Location: Off Campus Location
Organized By: Center for Cell Plasticity and Organ Design

The Center for Cell Plasticity and Organ Design is proud to present the following seminar with guest speaker Ralph Marcucio, PhD, Professor, School of Medicine and Director, Laboratory for Skeletal Regeneration Orthopaedic Trauma Institute at University of California, San Francisco.

The talk is entitled, "Life, Death and Transformation in the Transition Zone: an Emerging Model of Endochondral Ossification."

Faculty Host: Kurt Hankenson, PhD, Orthopaedic Surgery

For more information, please email: Organogenesis@umich.edu

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Lecture / Discussion Tue, 12 Apr 2022 10:29:34 -0400 2022-04-19T16:00:00-04:00 2022-04-19T17:00:00-04:00 Off Campus Location Center for Cell Plasticity and Organ Design Lecture / Discussion Flyer
Perspectives on Leadership from the Nation's Doctor (April 19, 2022 4:00pm) https://events.umich.edu/event/94250 94250-21726704@events.umich.edu Event Begins: Tuesday, April 19, 2022 4:00pm
Location: Off Campus Location
Organized By: School of Public Health

Join us for a virtual conversation with Dr. Jerome Adams and School of Public Health Dean DuBois Bowman. As the 20th U.S. Surgeon General and a prior member of the President’s Coronavirus task force, Dr. Adams has been at the forefront of America’s most pressing health challenges. Dr. Adams was appointed as a Presidential Fellow and the Executive Director of Purdue's Health Equity Initiatives on October 1, 2021. He is also a Distinguished Professor of Practice in the departments of Pharmacy Practice and Public Health. Dr. Adams is a licensed anesthesiologist with a master’s degree in public health, and ran the Indiana State Department of Health prior to becoming Surgeon General. This event is part of the School of Public Health's leadership speaker series "Ahead of the Curve." It is free and open to the public.

Please register to receive the streaming link.

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Livestream / Virtual Thu, 31 Mar 2022 23:08:22 -0400 2022-04-19T16:00:00-04:00 2022-04-19T17:00:00-04:00 Off Campus Location School of Public Health Livestream / Virtual Doctor Jerome Adams wearing his Public Health Corp uniform adorned with medals sitting in front of the American flag.
BioArtography - Call for Images (April 20, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742282@events.umich.edu Event Begins: Wednesday, April 20, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-20T00:00:00-04:00 2022-04-20T23:59:00-04:00 BioArtography Other U-M BioArtography
Powering on and off the forces that move mitotic chromosomes (April 20, 2022 9:30am) https://events.umich.edu/event/92912 92912-21698065@events.umich.edu Event Begins: Wednesday, April 20, 2022 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

CDB 2022 Seminar Series:

We are pleased to welcome Jason Stumpff, Ph.D., to the Kahn Auditorium in BSRB on April 20, 2022, to present his talk titled "Powering on and off the forces that move mitotic chromosomes".

In-Person & Virtual
Zoom Meeting link: https://umich.zoom.us/j/99868162700

Hosted By:
Kristen Verhey, Ph.D.
Ryoma Ohi, Ph.D.

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Lecture / Discussion Fri, 04 Mar 2022 08:59:50 -0500 2022-04-20T09:30:00-04:00 2022-04-20T10:30:00-04:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion Powering on and off the forces that move mitotic chromosomes
BioArtography - Call for Images (April 21, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742283@events.umich.edu Event Begins: Thursday, April 21, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-21T00:00:00-04:00 2022-04-21T23:59:00-04:00 BioArtography Other U-M BioArtography
BioArtography - Call for Images (April 22, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742284@events.umich.edu Event Begins: Friday, April 22, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-22T00:00:00-04:00 2022-04-22T23:59:00-04:00 BioArtography Other U-M BioArtography
Tools for multiplexed and scalable observations of cell physiology (April 25, 2022 9:30am) https://events.umich.edu/event/94621 94621-21752801@events.umich.edu Event Begins: Monday, April 25, 2022 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

We are pleased to welcome Changyang Linghu, Ph.D. to the Kahn Auditorium in BSRB on April 25, 2022 to present his talk titled "Tools for multiplexed and scalable observations of cell physiology"!

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Lecture / Discussion Thu, 14 Apr 2022 08:07:51 -0400 2022-04-25T09:30:00-04:00 2022-04-25T10:30:00-04:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion Tools for multiplexed and scalable observations of cell physiology
MCDB Pathways Master's Defense> Understanding the Role of Mitochondrial Pyruvate Carrier (MPC) Proteins in the Adaptive Mitochondrial Response to Endoplasmic Reticulum Stress (ERS) (April 25, 2022 10:00am) https://events.umich.edu/event/94794 94794-21768314@events.umich.edu Event Begins: Monday, April 25, 2022 10:00am
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Mentor: Amy Chang

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Workshop / Seminar Fri, 22 Apr 2022 15:37:09 -0400 2022-04-25T10:00:00-04:00 2022-04-25T11:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow initials MCDB and cartoon of a microscope on a blue background
EEB Special Seminar: Epidemiology at the interface of ecology and evolution (April 25, 2022 2:00pm) https://events.umich.edu/event/94684 94684-21759833@events.umich.edu Event Begins: Monday, April 25, 2022 2:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

The central organizing principle of infectious disease epidemiology is that the patterns of the occurrence of illness within and between populations are explainable by factors attributable to the host, agent, and environment. This is the so-called epidemiological trinity. In this talk I will discuss how epidemiological science has been enriched by increasingly embracing methods from evolutionary biology and ecology, and how realization of a modern pandemic science requires traditional boundaries between disciplines to be dissolved. First, I will illustrate how phylodynamic methods have provided a new view of old, unresolved questions in the epidemiology of HIV. From there I will talk about both the confounding and illuminating role of genetic diversity focusing on within-host diversity in chronic viral infections that can act both as noise and as a type of epidemiological signal. These points will be further illustrated by consideration of recombination as a potential confounding variable in epidemiological studies. Finally, I will discuss two of our ongoing studies that illustrate this new kind of pandemic science: one that attempts to integrate multi-scale (intracellular and epidemiological) dynamics of Crimean-Congo hemorrhagic fever virus in Turkey and Tajikistan with longitudinal field sampling of ticks from small mammals, ungulates, birds in regions with human cases of CCHFV. The second study looks to the future by using the DOE’s Earth System Model to project high-resolution climate change scenarios to predict the future landscape for mosquito borne diseases globally.

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Workshop / Seminar Wed, 20 Apr 2022 15:59:55 -0400 2022-04-25T14:00:00-04:00 2022-04-25T15:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Romero-Severson talk image
Connecting the Fiber Between Neurodegenerative Disease and the Microbiome- Department of Biological Chemistry Seminar (April 26, 2022 12:00pm) https://events.umich.edu/event/92447 92447-21691565@events.umich.edu Event Begins: Tuesday, April 26, 2022 12:00pm
Location: Medical Science Unit I
Organized By: Biological Chemistry

Dr. Chapman will give a seminar on Tuesday 4/26/22 at 12 noon in room 5330 MS I

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Workshop / Seminar Wed, 16 Feb 2022 13:01:26 -0500 2022-04-26T12:00:00-04:00 2022-04-26T13:00:00-04:00 Medical Science Unit I Biological Chemistry Workshop / Seminar Chapman
MCDB Pathways Masters Defense> The Glass Half Full: The Positive Role of Beta-catenin's N-terminus in Wnt Signaling (April 26, 2022 2:00pm) https://events.umich.edu/event/94793 94793-21768313@events.umich.edu Event Begins: Tuesday, April 26, 2022 2:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Mentor: Ken Cadigan

Also zoom:
email mcdb.seminar.info@umich.edu for info

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Workshop / Seminar Fri, 22 Apr 2022 15:33:55 -0400 2022-04-26T14:00:00-04:00 2022-04-26T15:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow initials MCDB and cartoon of a microscope on a blue background
Pamela V. Chang (April 26, 2022 4:00pm) https://events.umich.edu/event/85229 85229-21626007@events.umich.edu Event Begins: Tuesday, April 26, 2022 4:00pm
Location: Off Campus Location
Organized By: Department of Chemistry

Chembio
Pamela Chang (Cornell University)

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Other Tue, 26 Apr 2022 18:15:08 -0400 2022-04-26T16:00:00-04:00 2022-04-26T17:30:00-04:00 Off Campus Location Department of Chemistry Other
EEB Special Seminar: Human and wildlife health through the lens of bat-vector-microbiome interactions (April 27, 2022 2:00pm) https://events.umich.edu/event/94693 94693-21760270@events.umich.edu Event Begins: Wednesday, April 27, 2022 2:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Host-pathogen interactions are often viewed solely within the context of the evolution and ecology of these two organisms, but non-pathogenic microorganisms associated with a host or vector also mediate pathogen transmission and infection success. This microbiome, made up of pathogenic and non-pathogenic organisms, is therefore integral in understanding host-pathogen dynamics and vector-borne disease ecology. Leveraging natural history collections and field-based systems, I study the interactions between bats, arthropod vectors, and microorganisms using genomics, ecological networks, and machine learning. These host-vector-microbiome interactions provide a model for examining how complex biological communities respond to environmental change and novel disease emergence. Through M-PABI, my future research will continue to build these types of community models, develop collections as One Health resources, and facilitate coordination among institutions, public health professionals, wildlife and pathogen researchers, and communities in zoonotic hot spots. Extending our view of biological communities to include microorganisms is an imperative step towards combating zoonotic events and in maintaining healthy ecosystems. We can harness the information in natural history collections to help us achieve a more holistic approach to spillover prediction and prevention. Hybrid Event - Contact the department for information.

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Workshop / Seminar Wed, 20 Apr 2022 16:00:25 -0400 2022-04-27T14:00:00-04:00 2022-04-27T15:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Pteronotus mesoamericanus 852_2213_Photo credit M. Brock Fenton
MCDB Dissertation Defense > Profiling Neuronal Stress Responses Regulated by DLK in Synapse Loss, Inflammation and Cell Death (April 27, 2022 2:00pm) https://events.umich.edu/event/94792 94792-21768312@events.umich.edu Event Begins: Wednesday, April 27, 2022 2:00pm
Location: Molecular and Behavioral Neuroscience Institute
Organized By: Department of Molecular, Cellular, and Developmental Biology

Mentor: Catherine Collins

Also zoom
see the weekly update or
email mcdb.seminar.info@umich.edu

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Workshop / Seminar Fri, 22 Apr 2022 15:29:06 -0400 2022-04-27T14:00:00-04:00 2022-04-27T15:00:00-04:00 Molecular and Behavioral Neuroscience Institute Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow MCDB initials and drawing of microscope on blue
Controlling Localized Surface Plasmons via an Atomistic Approach: Chemical Analysis at Angstrom Scale and Site-Selective Reactions at Sub-Molecular Scale (April 27, 2022 4:00pm) https://events.umich.edu/event/84370 84370-21623616@events.umich.edu Event Begins: Wednesday, April 27, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

My research group is interested in investigating how local chemical environments affect single-molecule behaviors with angstrom scale resolution. This talk will start from Tip-Enhanced Raman Spectroscopy (TERS), which affords the spatial resolution of traditional Scanning Tunneling Microscopy (STM) while collecting the chemical information provided by Raman spectroscopy. By using a plasmonically-active material for our scanning probe, the Raman signal at the tip-sample junction is incredibly enhanced, allowing for single-molecule probing. This method, further aided by the benefits of ultrahigh vacuum, is uniquely capable of controlling localized plasmons via an atomistic approach. We are able to obtain (1) single-molecule chemical identification; (2) the configurations and orientations of individual molecules on the surface; (3) adsorbate-substrate interactions in the ordering of molecular building blocks in supramolecular nanostructures; (4) local strain effects in an organic/2D materials heterostructure. By investigating substrate structures, superstructures, 2D materials lattices, and the adsorption orientations obtained from vibrational modes, we extract novel surface-chemistry information at an unprecedented spatial (< 1 nm) and energy (< 10 wavenumber) resolution. Another application of localized surface plasmons is to achieve site-selective chemical reactions at sub-molecular scale. We recently selectively and precisely activated multiple chemically equivalent reactive sites one by one within the structure of a single molecule by scanning probe microscopy tip-controlled plasmonic resonance. Our method can interrogate the mechanisms of forming and breaking chemical bonds at the angstrom scale in various chemical environments, which is critical in designing new atom- and energy-efficient materials and molecular assemblies with tailored chemical properties.



Nan Jiang (University of Illinois Chicago)

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Other Wed, 27 Apr 2022 18:15:12 -0400 2022-04-27T16:00:00-04:00 2022-04-27T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
ER contact sites regulate the structure and function of other organelles (April 27, 2022 4:00pm) https://events.umich.edu/event/93244 93244-21701936@events.umich.edu Event Begins: Wednesday, April 27, 2022 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

We are pleased to welcome Gia K. Voeltz, Ph.D. to the Kahn Auditorium in BSRB on April 13, 2022, to present her talk titled ER contact sites regulate the structure and function of other organelles!

Dr. Voeltz's talk will be at 4 pm with a reception following her talk, from 5:15 - 6:15 pm in the BSRB ABC Conference rooms. This will be an in-person and live presentation. Zoom Meeting Link: https://umich.zoom.us/j/91951156709

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Lecture / Discussion Mon, 14 Mar 2022 16:55:53 -0400 2022-04-27T16:00:00-04:00 2022-04-27T17:00:00-04:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion ER contact sites regulate the structure and function of other organelles
Africa-US Collaborations in Health: Observations from Kenya (April 28, 2022 10:00am) https://events.umich.edu/event/93873 93873-21709208@events.umich.edu Event Begins: Thursday, April 28, 2022 10:00am
Location: Michigan League
Organized By: Center for Global Health Equity

Dr. Lukoye Atwoli, professor of psychiatry at Aga Khan University and a leader of health initiatives around the globe, will share his reflections on collaborations between African and US partners that have advanced health in recent decades. Dr. Atwoli will share lessons he and others learned from their engagement with a range of projects, including the AMPATH research network.

This in-person discussion with a global health leader is a unique opportunity, especially for anyone interested in health sciences research and other collaborations in Africa.

Light refreshments will be served. RSVP at myumi.ch/pZd4y.

Co-Sponsored by the African Studies Center and the Center for Global Health Equity

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Presentation Wed, 23 Mar 2022 14:32:59 -0400 2022-04-28T10:00:00-04:00 2022-04-28T11:00:00-04:00 Michigan League Center for Global Health Equity Presentation Dr. Lukoye Atwoli addresses AKU and U-M colleagues in Nairobi, Kenya
Quantitative and Mechanistic Studies on the Spindle Assembly Checkpoint in Human Cells Reveal the Origin of Its Sensitivity (April 28, 2022 12:00pm) https://events.umich.edu/event/94620 94620-21752798@events.umich.edu Event Begins: Thursday, April 28, 2022 12:00pm
Location: Off Campus Location
Organized By: Cell & Developmental Biology

We are pleased to announce that Chu Chen will present his Dissertation Defense on Quantitative and Mechanistic Studies on the Spindle Assembly Checkpoint in Human Cells Reveal the Origin of Its Sensitivity, on April 28, 2022 at 12:00 pm, via Zoom - Meeting ID: 913 5349 2573 Passcode: 022515

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Lecture / Discussion Thu, 14 Apr 2022 07:52:45 -0400 2022-04-28T12:00:00-04:00 2022-04-28T13:00:00-04:00 Off Campus Location Cell & Developmental Biology Lecture / Discussion Quantitative and Mechanistic Studies on the Spindle Assembly Checkpoint in Human Cells Reveal the Origin of Its Sensitivity
U-M Structure Seminar: "Structural and kinetic characterization of a minimal archaeal RNase P" (April 29, 2022 10:00am) https://events.umich.edu/event/85441 85441-21626428@events.umich.edu Event Begins: Friday, April 29, 2022 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

Catherine Wilhelm
Graduate Student
University of Michigan, Koutmos Lab

Hybrid: LSI Library and Zoom - https://umich.zoom.us/j/97763780708 (Password: structure)

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Workshop / Seminar Mon, 11 Apr 2022 14:00:58 -0400 2022-04-29T10:00:00-04:00 2022-04-29T11:00:00-04:00 Life Sciences Institute U-M Structural Biology Workshop / Seminar U-M Structure
EEB Special Seminar: Phylogenomic tracking of SARS-CoV-2 and emerging coronavirus zoonoses (May 2, 2022 2:00pm) https://events.umich.edu/event/94686 94686-21759835@events.umich.edu Event Begins: Monday, May 2, 2022 2:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

In this talk Dr. Mavian will present the genomic Real-time High-throughput genomic epidemiology monitoring system that has been developed at University of Florida to track spread, evolution and emergence of new variants in Florida, in collaboration with University of Central Florida and of Miami, and in Haiti in collaboration with GHESKIO. Dr. Mavian will also show the investigations of novel zoonotic coronaviruses that emerged in Haiti and that highlights coronaviruses’ potential for rapid evolution and frequent recombination, leading to periodic emergence of strains capable of crossing species barriers into human populations.

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Workshop / Seminar Wed, 20 Apr 2022 16:00:59 -0400 2022-05-02T14:00:00-04:00 2022-05-02T15:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Carla Mavian SARS-CoV2 image
"Delivering insights into organ homeostasis and regeneration through in vivo genome-wide screens.” (May 3, 2022 4:00pm) https://events.umich.edu/event/80291 80291-20684226@events.umich.edu Event Begins: Tuesday, May 3, 2022 4:00pm
Location: Off Campus Location
Organized By: Center for Cell Plasticity and Organ Design

The Center for Cell Plasticity and Organ Design presents the NIH T32 Training Program in Organogenesis Seminar Series: "Building and Rebuilding: Regulation of Cell Signaling in Development and Regeneration" featuring guest speaker Kristen Knouse, MD, PhD.

Dr. Knouse is an Assistant Professor in the Department of Biology at Massachusetts Institute of Technology.

The talk is entitled, "Delivering insights into organ homeostasis and regeneration through in vivo genome-wide screens.”

Trainee Host: Erez Cohen, PhD-Coulombe Lab

For more info email: Organogenesis@umich.edu

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Lecture / Discussion Fri, 22 Apr 2022 11:42:11 -0400 2022-05-03T16:00:00-04:00 2022-05-03T17:00:00-04:00 Off Campus Location Center for Cell Plasticity and Organ Design Lecture / Discussion Flyer
Mohammad R. Seyedsayamdost (May 3, 2022 4:00pm) https://events.umich.edu/event/88355 88355-21653505@events.umich.edu Event Begins: Tuesday, May 3, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Chembio
Mohammad Seyedsayamdost (Princeton)

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Other Wed, 06 Apr 2022 06:15:29 -0400 2022-05-03T16:00:00-04:00 2022-05-03T17:15:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
TBA (May 3, 2022 4:00pm) https://events.umich.edu/event/91342 91342-21678331@events.umich.edu Event Begins: Tuesday, May 3, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Materials
Mohammad Seyedsayamdost

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Other Wed, 06 Apr 2022 06:15:29 -0400 2022-05-03T16:00:00-04:00 2022-05-03T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Interdisciplinary QC/CM Seminar | Manifestation of Spin-Orbit and Electron-Nuclear Couplings in Computational Molecular Spectroscopy (May 5, 2022 4:00pm) https://events.umich.edu/event/91345 91345-21678334@events.umich.edu Event Begins: Thursday, May 5, 2022 4:00pm
Location: West Hall
Organized By: Department of Chemistry

The computational modeling of molecular spectroscopies requires an accurate treatment of spin-orbit and electron-nuclear couplings to fully understand the physical underpinnings of the spectroscopic signatures. In this talk, I will briefly review recent developments in relativistic electronic structure theory and electron-nuclear quantum dynamics from the Li research group, followed by computational studies of several advanced molecular spectroscopies and challenging chemical processes. L- and M-edge X-ray absorption, where large spin-orbit coupling splits the core p/d orbitals into several sublevels, can now be computed with relativistic electronic structure methods developed in the Li research group. These new methods can provide extremely important insights into chemical processes involving transition metal, rare earth, and heavy elements. In order to study the effect of quantum proton, we have developed the nuclear-electronic orbital Ehrenfest (NEO-Ehrenfest) dynamics, in collaboration with the Hammes-Schiffer group. NEO-Ehrenfest provides an elegant framework for treating electrons and selected nuclei, typically protons, quantum mechanically in nonequilibrium dynamical processes, such as the excited state intramolecular proton transfer process. Our simulations reveal that nuclear quantum effects influence the predictions of proton transfer reaction rates and kinetic isotope effects due to the intrinsic delocalized nature of the quantum nuclear wave function.
Xiaosong Li (University of Washington)

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Other Thu, 05 May 2022 18:15:06 -0400 2022-05-05T16:00:00-04:00 2022-05-05T17:30:00-04:00 West Hall Department of Chemistry Other West Hall
A Multicellular, Biomaterial-based Platform for the Engineering of Vascularized Bone (May 9, 2022 11:00am) https://events.umich.edu/event/94843 94843-21776805@events.umich.edu Event Begins: Monday, May 9, 2022 11:00am
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: Biomedical Engineering

Cell-based tissue engineering offers the potential to greatly improve the treatment of large and complex bone defects by addressing the main shortcomings associated with current bone grafting procedures. A main challenge is the ischemic environment that can result from traumatic bone injury, resulting in the death of transplanted cells and tissue constructs. Achieving an adequate vascular supply is a critical barrier preventing the translational success of cell-based regeneration approaches. Therefore, a variety of strategies have been developed to prevascularize engineered tissue constructs prior to transplantation. Adult mesenchymal stromal cells (MSC) and endothelial cells (EC) are key players in native orthopaedic tissue regeneration and vascularization, and represent promising cell types for tissue engineering strategies to create vascularized bone. However, to effectively harness the regenerative potential of MSC, the appropriate phenotype must be achieved before implantation. A main challenge in engineering vascularized bone tissue is creating an appropriate culture environment to support multiple cell phenotypes. Therefore, this work focuses on designing a cell-based, biomaterial-enabled strategy that provides spatiotemporal control of key microenvironmental cues to support the co-development of osseous and vascular tissues, with the end goal of generating vascularized, bone-forming constructs.

First, this thesis explores how temporal control of the culture environment can be used to maintain preformed vessels and subsequent osteogenic development in engineered tissue constructs. To mimic the sequential process of native bone development, in which vascularization precedes tissue ossification, we generated cell-laden hydrogel constructs cultured in vasculogenic growth medium to induce vessel development, and subsequently supplemented the medium with osteoinductive components to promote osteogenic differentiation. Our results revealed conflicting effects of the two culture environments, in which osteoinductive factors compromised cellular viability and MSC pericyte-like function, leading to ~93% regression of preformed vessels. Further, vasculogenic culture conditions inhibited MSC-mediated matrix mineralization as evidenced by impaired calcium deposition.

Next, this thesis describes the development and characterization of a modular biomaterial approach that provides control of discrete environmental properties designed to promote vasculogenic and osteogenic tissue development. Separate populations of cell-laden microtissues were fabricated and independently cultured under specific differentiation conditions to support either osteogenic or pericyte-like lineage commitment of MSC. This approach enabled the formation of primitive osteogenic microtissues exhibiting mineralization of the extracellular matrix, and vascular microtissues with demonstrated EC sprouting potential. The combination of microtissues led to the generation of a multiphase construct that supported extensive vessel development. While osteogenic activity was maintained without exogenous osteoinductive factors, the vasculogenic culture environment was not conducive for sustained mineralization.

Lastly, this thesis describes a novel approach incorporating the modular biomaterial platform with a biomimetic induction process emulating the native endochondral ossification (EO) pathway to better couple vascular and osteogenic tissue development. Chondrogenically-primed MSC were matured to hypertrophy to form hypertrophic pellets resembling EO, as evidenced by MMP-mediated remodeling and mineralization of the formed cartilaginous matrix. Hypertrophic induction of MSC was associated with secretion of distinct angiogenic factors which stimulated EC vasculogenesis. When combined with vasculogenic microtissues, hypertrophic pellets supported robust vessel development and cell-mediated mineralization without exogenous vasculogenic medium or osteoinductive components.

Overall, this dissertation presents an attractive strategy for generating vascularized bone-like tissue. By integrating the modular biomaterial platform with an EO-based induction process, we successfully leveraged physiologic cues of hypertrophic MSC to achieve concomitant vasculogenic and osteogenic development.

Date: Monday, May 9, 2022
Time: 11:00 AM
Location: 1130 LBME and Zoom (https://umich.zoom.us/j/96133803682 Passcode: bones)
Chair: Dr. Jan Stegemann

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Presentation Wed, 27 Apr 2022 14:28:01 -0400 2022-05-09T11:00:00-04:00 2022-05-09T12:00:00-04:00 Lurie Biomedical Engineering (formerly ATL) Biomedical Engineering Presentation BME PhD Defense
MCDB PhD Defense> Uncovering Reproductive Roles of Cell Wall Glycoproteins in Flowering Plants (May 9, 2022 2:00pm) https://events.umich.edu/event/94880 94880-21780185@events.umich.edu Event Begins: Monday, May 9, 2022 2:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Mentor: Cora MacAlister

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Workshop / Seminar Fri, 29 Apr 2022 12:16:02 -0400 2022-05-09T14:00:00-04:00 2022-05-09T15:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow initials MCDB and cartoon of a microscope on a blue background
RNA Innovation Seminar: "Unexpected determinants of neuronal identity and properties: the curious cases of PTBP1, PTBP2, and neuronal splicing" (May 9, 2022 4:00pm) https://events.umich.edu/event/92835 92835-21697179@events.umich.edu Event Begins: Monday, May 9, 2022 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

Virtual Seminar via Zoom: https://umich.zoom.us/webinar/register/WN_dltbxWdHQ5KrC3rTl4hqLQ

Talk title: “Unexpected determinants of neuronal identity and properties: the curious cases of PTBP1, PTBP2, and neuronal splicing"

Abstract: Alternative splicing is the major contributor to transcriptome diversity, but splicing is noisy and to what extend alternative splicing regulation is indispensable for biolgical processes has been controversial. Our studies have revealed the regulation and function of neural-specific splicing in shaping neuronal identity and estalishing neurons’ two unique attributes: 1. Axonogenesis (Only neurons but no other cell types have one and single axon); 2. Neuronal longevity (Neurons are the most long-lived cell types). We show that obtaining these neuronal features is coordinated by RNA binding proteins PTBP1 and PTBP2, while PTBP1 was suggested by others to be a reprogramming factor of neuronal fate. I will discuss the regulatory mechanism of neural specific splicing underlying neurogensis and maturation.

References:
Zhang M, Ergin V, Lin L, Stork C, Chen L, Zheng S. Neuron. 2019 Feb 20;101(4):690-706.e10.
Ergin V, Zheng S. J Mol Biol. 2020 Jun 26;432(14):4154-4166.
Zheng S. Wiley Interdiscip Rev RNA. 2020 Jul;11(4):e1585.
Lin L, Zhang M, Stoilov P, Chen L, Zheng S. Neuron. 2020 Sep 23;107(6):1180-1196.e8.
Vuong J, Ergin V, Zheng S. Nature Communications (accepted)

If you are having trouble registering, please contact Martina Jerant at mjerant@umich.edu

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Lecture / Discussion Mon, 25 Apr 2022 10:11:18 -0400 2022-05-09T16:00:00-04:00 2022-05-09T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Sika Zheng, UC Riverside, School of Medicine
Mike Shapiro, PhD-Variations In Biology Seminar Series (May 10, 2022 4:00pm) https://events.umich.edu/event/87453 87453-21642263@events.umich.edu Event Begins: Tuesday, May 10, 2022 4:00pm
Location: Off Campus Location
Organized By: Center for Cell Plasticity and Organ Design

The Center for Cell Plasticity and Organ Design alongside
The Molecular, Cellular, and Developmental Biology,
Ecology and Evolutionary Biology departments and the
Cell and Molecular Biology CMB/Genetics Training Programs
are proud to present:

Mike Shapiro, PhD
James E. Talmage Presidential Endowed Chair in Biology
Professor, School of Biological Sciences
Adjunct Professor, Department of Human Genetics

Faculty Host: Sundeep Kalantry, PhD, Human Genetics

For more information/questions email: Organogenesis@umich.edu

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Workshop / Seminar Fri, 22 Apr 2022 12:01:42 -0400 2022-05-10T16:00:00-04:00 2022-05-10T17:00:00-04:00 Off Campus Location Center for Cell Plasticity and Organ Design Workshop / Seminar flyer
2022 Caswell Diabetes Institute - Metabolism, Obesity & Diabetes (CDI-MOD) and the Frontiers in Diabetes Complications Symposium (May 11, 2022 8:00am) https://events.umich.edu/event/94750 94750-21764822@events.umich.edu Event Begins: Wednesday, May 11, 2022 8:00am
Location: North Campus Research Complex Building 18
Organized By: Caswell Diabetes Institute

The CDI-MOD and Frontiers in Diabetes Complications Symposium provides a forum for intellectual exchange on topics associated with diabetes, obesity, metabolism and related complications among established investigators, junior faculty, students, and other researchers at the University of Michigan (U-M) and surrounding areas. This symposium features two days of invited speakers with a lively debate, poster session and data blitz, providing time for discussion and exploration of new collaborations. Speakers include a combination of researchers of international stature from outside of U-M and junior and senior faculty within the University. Symposium participants will enhance their knowledge and understanding of the latest advances in basic, translational and clinical research as well as the latest advances in the care and treatment of diabetes, obesity, metabolism and related complications. After this activity, participants will be able to elucidate and predict more clear causes of diabetes and metabolic diseases and utilize this information to guide future research. The target audience includes physicians, house officers, medical students, technicians, administrators and other healthcare professionals.

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Conference / Symposium Wed, 20 Apr 2022 15:14:09 -0400 2022-05-11T08:00:00-04:00 2022-05-11T18:00:00-04:00 North Campus Research Complex Building 18 Caswell Diabetes Institute Conference / Symposium CDI-MOD Complications Schedule-At-A-Glance
Signaling, illuminated: moving proteins and assembling organelles to crack the signaling code (May 11, 2022 9:30am) https://events.umich.edu/event/94756 94756-21766113@events.umich.edu Event Begins: Wednesday, May 11, 2022 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

We are pleased to announce that Jared Toettcher, Ph.D. will present his talk titled "Signaling, illuminated: moving proteins and assembling organelles to crack the signaling code", on May 11, 2022, at 9:30 am, in-person in Conference Rooms ABC (BSRB) and via live stream: Meeting Link: https://umich.zoom.us/j/99500831857

Hosted By:
Idse Heemskert, Ph.D.
Ajit Joglekar, Ph.D.

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Lecture / Discussion Thu, 21 Apr 2022 09:03:11 -0400 2022-05-11T09:30:00-04:00 2022-05-11T10:30:00-04:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion Signaling, illuminated: moving proteins and assembling organelles to crack the signaling code
2022 Caswell Diabetes Institute - Metabolism, Obesity & Diabetes (CDI-MOD) and the Frontiers in Diabetes Complications Symposium (May 12, 2022 8:00am) https://events.umich.edu/event/94750 94750-21764823@events.umich.edu Event Begins: Thursday, May 12, 2022 8:00am
Location: North Campus Research Complex Building 18
Organized By: Caswell Diabetes Institute

The CDI-MOD and Frontiers in Diabetes Complications Symposium provides a forum for intellectual exchange on topics associated with diabetes, obesity, metabolism and related complications among established investigators, junior faculty, students, and other researchers at the University of Michigan (U-M) and surrounding areas. This symposium features two days of invited speakers with a lively debate, poster session and data blitz, providing time for discussion and exploration of new collaborations. Speakers include a combination of researchers of international stature from outside of U-M and junior and senior faculty within the University. Symposium participants will enhance their knowledge and understanding of the latest advances in basic, translational and clinical research as well as the latest advances in the care and treatment of diabetes, obesity, metabolism and related complications. After this activity, participants will be able to elucidate and predict more clear causes of diabetes and metabolic diseases and utilize this information to guide future research. The target audience includes physicians, house officers, medical students, technicians, administrators and other healthcare professionals.

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Conference / Symposium Wed, 20 Apr 2022 15:14:09 -0400 2022-05-12T08:00:00-04:00 2022-05-12T17:00:00-04:00 North Campus Research Complex Building 18 Caswell Diabetes Institute Conference / Symposium CDI-MOD Complications Schedule-At-A-Glance
2022 MaryFran Sowers Memorial Symposium (Day 1, May 12) (May 12, 2022 1:30pm) https://events.umich.edu/event/92998 92998-21698986@events.umich.edu Event Begins: Thursday, May 12, 2022 1:30pm
Location: Off Campus Location
Organized By: Center for Midlife Science

*featuring the career of Siobán D. Harlow, PhD, (Professor Emerita of Epidemiology, Global Public Health, and Obstetrics & Gynecology)*

**REGISTER TODAY** (In-person and virtual attendance options available)

http://midlifescience.umich.edu/Event_Sowers2022.php

Keynote speaker Dr. Fugate Woods is Professor Emerita, University of Washington School of Nursing, and Co-Director, de Tornyay Center for Healthy Aging.

**May 12 (Thursday)1:30-4:30 pm**
Welcome: SPH Dean Dubois Bowman
Keynote address: Nancy Fugate Woods "Women's Lives, Women's Health Across the Lifespan"

Michael Elliott, PhD: "What Makes a Good Collaboration? An Exemplary Example in My Work with Professor Sioban Harlow"

Kristin Dunkle, PhD: "From Prevalence to Effective Prevention: Evolution of Epidemiological Research on Gender-based Violence"

Alexis Reeves, PhD: "Addressing Racially Diverse Trajectories of Health in Women - Methodological Challenges and Implications"

Reception: Organized by Epidemiology Dept.

Registration required. Please see webpage for more information and registration.
http://midlifescience.umich.edu/SOWERS2022

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Conference / Symposium Fri, 06 May 2022 14:02:54 -0400 2022-05-12T13:30:00-04:00 2022-05-12T16:30:00-04:00 Off Campus Location Center for Midlife Science Conference / Symposium MaryFran Sowers Memorial Symposium featuring the career of Siobán Harlow
Scalable online modeling and perturbations for adaptive neuroscience experiments (May 12, 2022 3:30pm) https://events.umich.edu/event/95066 95066-21788408@events.umich.edu Event Begins: Thursday, May 12, 2022 3:30pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: Biomedical Engineering

Abstract:
Systems neuroscience is increasingly able to leverage new recording tools and statistical analyses to describe the coordinated activity of large neuronal populations, even entire brains. Combined with precise stimulation technologies, we could begin to dissect large-scale circuits in vivo, constructing models that causally relate neural activity to behavior. Perturbative testing of hypothesized brain-behavior links, however, requires statistically efficient methods for both estimating and intervening on population-level neural dynamics in real time. To build neural models online, we describe a new machine learning method that combines fast, stable dimensionality reduction with a soft tiling of the resulting neural manifold, allowing dynamics to be approximated as a probability flow between tiles. This method can be fit efficiently, scales to large populations, and outperforms existing methods when dynamics are noise-dominated or feature multi-modal transition probabilities. Using online modeling, we can also ‘close the loop’ by selecting optimal circuit interventions to create maps of causal influence within large networks. Our algorithm uses online convex optimization and adaptive stimulation selection to quickly infer the binary network connectivity, rendering the inference of networks of tens of thousands of neurons in vivo feasible in a single experiment. We additionally present a neural response optimization method with multi-output Gaussian processes that uses active stimulus selection to acquire data at locations where models are likeliest to be wrong given the data seen so far. These methods, which combine online neural modeling with adaptive intervention, open the door to automated, theory-driven circuit dissection at scale, providing a powerful new means of interrogating neural function.

Bio:
Dr. Anne Draelos is a Postdoctoral Associate in the Pearson Lab at Duke University focused on machine learning and statistical techniques to facilitate real-time analysis of high-dimensional neural and behavioral data. She is currently a Swartz Foundation Fellow for Theory in Neuroscience and received a 2021 Career Awards at the Scientific Interface from the Burroughs Wellcome Fund.

Zoom Link: https://umich.zoom.us/j/91252848761?pwd=MkpCaDRHcjlRRWxuUzFEakQyM1RYUT09

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Lecture / Discussion Tue, 10 May 2022 10:07:27 -0400 2022-05-12T15:30:00-04:00 2022-05-12T16:30:00-04:00 Lurie Biomedical Engineering (formerly ATL) Biomedical Engineering Lecture / Discussion BME Seminar Event
Saltiel Life Sciences Symposium 2022 (May 13, 2022 8:45am) https://events.umich.edu/event/92402 92402-21690852@events.umich.edu Event Begins: Friday, May 13, 2022 8:45am
Location: Taubman Biomedical Science Research Building
Organized By: Life Sciences Institute (LSI)

*Viral Pathogens: Us vs. Them*

Schedule:

8:45 a.m. | Welcome
Roger D. Cone, Ph.D.
Vice Provost and Director, U-M Biosciences Initiative; Mary Sue Coleman Director, Life Sciences Institute; Professor of Molecular and Integrative Physiology, Medical School; Professor of Molecular, Cellular, and Developmental Biology, College of Literature, Science, and the Arts

8:50 a.m. | Introduction of the Mary Sue and Kenneth Coleman Life Sciences Lecturer
Mary Sue Coleman, Ph.D.
President of the University of Michigan

9:00 a.m. | Mary Sue and Kenneth Coleman Life Sciences Lecture — Structural correlates of antibody neutralization of viruses
Pamela Bjorkman, Ph.D.
David Baltimore Professor of Biology and Biological Engineering, Merkin Institute Professor, California Institute of Technology

9:50 a.m. | Morning break

10:10 a.m. | Next generation nucleic acid vaccines
Deborah Fuller, Ph.D.
Professor of Microbiology; Associate Director of Research, Washington National Primate Research Center, University of Washington

11:00 a.m. | Molecular mechanism for self vs. non-self RNA discrimination
Sun Hur, Ph.D.
Senior Investigator, Program in Cellular & Molecular Medicine;
Oscar M. Schloss, MD Professor of Pediatrics, Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Boston Children's Hospital; Investigator, Howard Hughes Medical Institute

11:50 a.m. | Poster session and lunch, BSRB ABC and Upper Atrium

1:20 p.m. | Noncoding RNA and triphosphate balance in virus infection
Chris Sullivan, Ph.D.
Professor of Molecular Biosciences, University of Texas at Austin

2:10 p.m. | Influenza in vulnerable populations
Stacey Schultz-Cherry, Ph.D.
Full Member, Department of Infectious Diseases; Deputy Director, World Health Organization Collaborating Center for Studies on the Ecology; Associate Dean of Student Affairs, St. Jude Graduate School for Biomedical Sciences, St Jude Children’s Research Hospital

3:00 p.m. | Afternoon break

3:20 p.m. | Rules of engagement between primate and viral genomes
Harmit Malik, Ph.D.
Professor and Associate Director, Basic Sciences Division, Fred Hutchinson Cancer Research Center; Investigator, Howard Hughes Medical Institute

4:10 p.m. | Closing remarks

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Workshop / Seminar Mon, 02 May 2022 10:52:17 -0400 2022-05-13T08:45:00-04:00 2022-05-13T16:30:00-04:00 Taubman Biomedical Science Research Building Life Sciences Institute (LSI) Workshop / Seminar Illustration of a chess board with text: Saltiel Life Sciences Symposium, Viral Pathogens: Us vs. Them
Intrahepatic paracrine signaling by CLCF1 ameliorates diet-induced NASH in mice (May 13, 2022 9:00am) https://events.umich.edu/event/94619 94619-21752797@events.umich.edu Event Begins: Friday, May 13, 2022 9:00am
Location: Palmer Commons
Organized By: Cell & Developmental Biology

We are pleased to announce that Tongyu Liu will present her Dissertation Defense on Intrahepatic paracrine signaling by CLCF1 ameliorates diet-induced NASH in mice, on May 13, 2022, at 9:00 am, in-person at Forum Hall, Palmer Commons, and via Livestream:https://umich.zoom.us/j/99759941291 Passcode: cdb

Hosted by the Dissertation Committee:
Jason Spence, Ph.D., Chair
Jiandie Lin, Ph.D., Mentor
Liangyou Rui, Ph.D.
Jun Li, Ph.D.

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Lecture / Discussion Thu, 14 Apr 2022 08:24:04 -0400 2022-05-13T09:00:00-04:00 2022-05-13T10:00:00-04:00 Palmer Commons Cell & Developmental Biology Lecture / Discussion Intrahepatic paracrine signaling by CLCF1 ameliorates diet-induced NASH in mice
2022 MaryFran Sowers Memorial Symposium (Day 2, May 13) (May 13, 2022 11:00am) https://events.umich.edu/event/93519 93519-21705222@events.umich.edu Event Begins: Friday, May 13, 2022 11:00am
Location: Off Campus Location
Organized By: Center for Midlife Science

*featuring the career of Siobán D. Harlow, PhD*

REGISTER TODAY (in person and virtual attendance options)
http://midlifescience.umich.edu/Event_Sowers2022.php

May 13 (Friday)11:00 am - 1:00 pm
Panel: The Future of Women's Health
Moderator, Nancy Fugate Wood

Panel A: NGO and Practice
With...
Lisa Zook, MPH (InformEd International)
Richa Mittal, MPH (Fair Labor Association)
Alain Mukwege, MD (Panzi Foundation)

Panel B: Research
With...
Alexis Handal, PhD (U of M)
Carrie Karvonen-Gutierrez, PhD (U of M)
Lynda Lisabeth, PhD (U of M)
Hilda Garcia, PhD (Colegio de Frontera Norte)

Registration required. Please see webpage for more information and registration.
http://midlifescience.umich.edu/SOWERS2022

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Conference / Symposium Mon, 25 Apr 2022 13:38:04 -0400 2022-05-13T11:00:00-04:00 2022-05-13T13:00:00-04:00 Off Campus Location Center for Midlife Science Conference / Symposium MaryFran Sowers Memorial Symposium featuring the career of Siobán Harlow
MCDB Seminar> Knowing me, knowing you: self and non-self recognition in plant immunity and beyond (May 13, 2022 12:00pm) https://events.umich.edu/event/94839 94839-21776801@events.umich.edu Event Begins: Friday, May 13, 2022 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Jianming Li

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Workshop / Seminar Wed, 27 Apr 2022 12:57:05 -0400 2022-05-13T12:00:00-04:00 2022-05-13T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow initials MCDB and cartoon of a microscope on a blue background
Roles for GLI Transcription Factors in Pancreas Development and Disease (May 16, 2022 10:00am) https://events.umich.edu/event/94798 94798-21771366@events.umich.edu Event Begins: Monday, May 16, 2022 10:00am
Location: Palmer Commons
Organized By: Cell & Developmental Biology

Dissertation Defense

We are pleased to announce that Michael Scales will present his Dissertation Defense on "Roles for GLI Transcription Factors in Pancreas Development and Disease" on Monday, May 16, 2022, at 10:00 a.m., in person at Forum Hall, Palmer Commons, and via live stream:

Meeting Link: Link: https://umich.zoom.us/j/93788826971 Passcode: GLI

Hosted By the Dissertation Committee:
Benjamin Allen, Ph.D. - Co-mentor
Marina Pasca di Magliano, Ph.D. - Co-mentor
Andrzej Dlugosz, M.D. - Chair
Deneen Wellik, Ph.D.
Howard Crawford, Ph.D.

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Lecture / Discussion Thu, 28 Apr 2022 13:35:25 -0400 2022-05-16T10:00:00-04:00 2022-05-16T11:00:00-04:00 Palmer Commons Cell & Developmental Biology Lecture / Discussion Roles for GLI Transcription Factors in Pancreas Development and Disease
RNA Innovation Seminar: "An Academic Approach to Oligonucleotide Therapeutics" (May 16, 2022 4:00pm) https://events.umich.edu/event/92837 92837-21697182@events.umich.edu Event Begins: Monday, May 16, 2022 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

In-person: BSRC, ABC seminar rooms
Livestream: https://myumi.ch/9Py8b

Talk title: “An Academic Approach to Oligonucleotide Therapeutics”

Keywords: Oligonucleotides, Chemical Modifications, RNA, Huntington’s Disease

Abstract: Nucleic acids (NA) are becoming the third major pillar of therapeutic modalities on par with small molecules and biologics. The diversity of NA molecular mechanisms, ranging from vaccines, antisense, short interfering RNA (siRNAs), and guide RNA for CRISPR gene editing systems, enable impact on most aspects of cellular biology and thus human medicine. The foundation behind the recent oligonucleotides' clinical success is fundamental chemical innovations in RNA stability, delivery, and synthesis.
Oligonucleotides are informational drugs; thus, if chemical architectures supporting safe and efficient delivery to the tissue of interest are achieved, they can be easily reprogrammed to modulate any gene expression on demand, creating an opportunity for academic institutions to drive therapeutic innovation. However, the process is limited by access to oligonucleotide chemistry and synthetic expertise.
In the first half of the talk, I will share the experience of building and running Nucleic Acid Chemistry Center in a context of a large academic institution. The NACC provides access to therapeutic quality screening leads and large manufacturing of preclinical compounds for the academic community. The impact of the NACC and chemical innovation will be discussed in the context of two significant projects. First, I will discuss the systematic structure-activity relationship study of chemical modifications to modulate RISC loading and cleavage. Screening 1200 siRNA variants allow for defining the chemical and thermodynamic rules for RISC assembly.
A recent discovery from our lab has identified di-valent siRNA as a scaffold enabling potent and sustained modulation of gene expression in CNS of rodents and NHP with multiple compounds advancing clinic. Recently, somatic repeat expansion has been identified as the driver behind many repeat-associated disorders. Indeed, modulation of MSH3, an essential gene involved in long repeat expansion, blocked somatic repeat expansion in the Q111 model of Huntington's Disease. I would present how access to NACC allowed the development and validation of the clinical lead and define a novel therapeutic approach for the treatment of HD.


If you are having trouble registering, please contact Martina Jerant at mjerant@umich.edu

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Lecture / Discussion Mon, 18 Apr 2022 17:23:23 -0400 2022-05-16T16:00:00-04:00 2022-05-16T17:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion Daniel O’Reilly, RNA Therapeutics Institute, UMassMed
Glenn V. Edmonson Lecture & 2022 Biomedical Engineering Symposium (May 18, 2022 10:00am) https://events.umich.edu/event/94970 94970-21788170@events.umich.edu Event Begins: Wednesday, May 18, 2022 10:00am
Location: Palmer Commons
Organized By: Biomedical Engineering

The Inaugural Glenn V. Edmonson Lecture and 2022 Biomedical Engineering Symposium are intended to build the BME community across campus and honor the legacy of the first graduate chair of the Biomedical Engineering program. These events will provide a forum for BME faculty and students campus-wide along with our collaborators to present current research progress and discuss future research opportunities at the interface of engineering and medicine.

The events will take place on Wednesday, May 18th, from 10:00 AM - 5:00 PM at Palmer Commons (4th Floor). Please RSVP by Friday, May 6th, 2022.

RSVP Link: https://forms.gle/QB7kS8UnQftWrZaX9

Schedule:
10:00 AM - 10:15 AM Welcome and Introduction from BME Interim Chair, Mary-Ann Mycek Ph.D., and Symposium Chairs, Rhima Coleman, Ph.D., and Tim Bruns, Ph.D.

10:15 AM - 11:05 AM Cell and In vitro
Sue Brooks Herzog, Ph.D.
Sherman Fan, Ph.D.
Geeta Mehta, Ph.D.

11:05 AM - 11:15 AM Break

11:15 AM - 12:05 PM In Vivo
Jiande Chen, Ph.D.
Megan Killian, Ph.D.
Cindy Chestek, Ph.D.

12:05 PM - 1:00 PM LUNCH BREAK - with Poster Viewing

1:00 PM - 1:50 PM Computational
Indika Rajapakse, Ph.D.
David Nordsletten, Ph.D.
Ellen Arruda, Ph.D.

1:50 PM - 2:00 PM Break

2:00 PM - 2:50 PM Clinical / Human Subjects
Susan Shore, Ph.D.
Jon-Fredrik Nielsen, Ph.D.
David Zopf, M.D., M.S.

2:50 PM - 3:00 PM Break

3:00 PM – 4:15 PM Glenn V. Edmonson Lecture
Paul Cederna, M.D. FACS

4:15 PM - 5:00 PM POSTER SESSION and Reception

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Conference / Symposium Wed, 04 May 2022 14:01:07 -0400 2022-05-18T10:00:00-04:00 2022-05-18T17:00:00-04:00 Palmer Commons Biomedical Engineering Conference / Symposium BME Symposium
Tissue Engineering and Regenerative Medicine Approaches to Study Fat-Cartilage Crosstalk (May 19, 2022 3:00pm) https://events.umich.edu/event/95137 95137-21788505@events.umich.edu Event Begins: Thursday, May 19, 2022 3:00pm
Location: Taubman Library
Organized By: Regenerative Medicine Biosciences Initiative

Dr. Collins received her PhD in Biomedical Engineering in 2017 in Dr. Walter Herzog’s lab at the University of Calgary on diet-induced obesity in a rat model of osteoarthritis. As a Postdoctoral Research Scholar in the Guilak Laboratory at Washington University in St. Louis, Kelsey has created a niche in adipose-cartilage signaling, stem-cell biology, synthetic biology, and drug delivery to evaluate systemic contributors and novel therapeutic strategies in osteoarthritis and rheumatoid arthritis.

This is a hybrid event, in-person at Taubman Library 2901, and also available via Zoom.

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Workshop / Seminar Fri, 13 May 2022 11:56:20 -0400 2022-05-19T15:00:00-04:00 2022-05-19T16:30:00-04:00 Taubman Library Regenerative Medicine Biosciences Initiative Workshop / Seminar Dr. Kelsey Collins
Tissue Engineering and Regenerative Medicine Approaches to Study Fat-Cartilage Crosstalk (May 19, 2022 3:00pm) https://events.umich.edu/event/95137 95137-21788506@events.umich.edu Event Begins: Thursday, May 19, 2022 3:00pm
Location: Off Campus Location
Organized By: Regenerative Medicine Biosciences Initiative

Dr. Collins received her PhD in Biomedical Engineering in 2017 in Dr. Walter Herzog’s lab at the University of Calgary on diet-induced obesity in a rat model of osteoarthritis. As a Postdoctoral Research Scholar in the Guilak Laboratory at Washington University in St. Louis, Kelsey has created a niche in adipose-cartilage signaling, stem-cell biology, synthetic biology, and drug delivery to evaluate systemic contributors and novel therapeutic strategies in osteoarthritis and rheumatoid arthritis.

This is a hybrid event, in-person at Taubman Library 2901, and also available via Zoom.

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Workshop / Seminar Fri, 13 May 2022 11:56:20 -0400 2022-05-19T15:00:00-04:00 2022-05-19T16:30:00-04:00 Off Campus Location Regenerative Medicine Biosciences Initiative Workshop / Seminar Dr. Kelsey Collins
MCDB Seminar> Liquids at Biological Synapses: How Phase Separation Regulates Cellular Organization and Function (May 20, 2022 12:00pm) https://events.umich.edu/event/94941 94941-21786535@events.umich.edu Event Begins: Friday, May 20, 2022 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host. Anthony Vecchiarelli

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Workshop / Seminar Mon, 16 May 2022 10:56:21 -0400 2022-05-20T12:00:00-04:00 2022-05-20T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow initials MCDB and cartoon of a microscope on a blue background
BIBC Research Seminar (May 20, 2022 4:00pm) https://events.umich.edu/event/94800 94800-21773057@events.umich.edu Event Begins: Friday, May 20, 2022 4:00pm
Location: North Campus Research Complex Building 10
Organized By: BioInnovations in Brain Cancer

The BIBC will be hosting its monthly seminar in a hybrid format on Friday, May 20, 4-5pm at the NCRC B10 Research Auditorium and over Zoom. This month's speakers will be Dr. Richard Keep and Dr. Anuska Andjelkovic-Zochowska to discuss their research on the blood brain barrier as it relates to disease models and therapeutics.

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Conference / Symposium Mon, 02 May 2022 10:53:33 -0400 2022-05-20T16:00:00-04:00 2022-05-20T17:00:00-04:00 North Campus Research Complex Building 10 BioInnovations in Brain Cancer Conference / Symposium BIBC May Seminar Flyer
RNA Innovation Seminar (May 23, 2022 4:00pm) https://events.umich.edu/event/92838 92838-21697183@events.umich.edu Event Begins: Monday, May 23, 2022 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

In-person/Hybrid seminar

“A miRNA-mediated approach to dissect the complexity of cancer progression and identify anti-cancer drugs”
Analisa DiFeo, Ph.D.
Associate Professor
Pathology and Ob/Gyn
Michigan Medicine

and

“The Role of piRNA in Environmental Epigenetics”
Bambarendage (Pini) Perera, Ph.D.
Research Assistant Professor
Environmental Health Sciences
School of Public Health

If you are having trouble registering, please contact Martina Jerant at mjerant@umich.edu

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Lecture / Discussion Mon, 09 May 2022 08:46:55 -0400 2022-05-23T16:00:00-04:00 2022-05-23T17:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion Analisa DiFeo & Bambarendage (Pini) Perera
Actin nucleation alliance: from yeast to human cells (May 25, 2022 9:30am) https://events.umich.edu/event/94757 94757-21766115@events.umich.edu Event Begins: Wednesday, May 25, 2022 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

We are pleased to announce that Bruce Lane Goode, Ph.D., will present his talk titled "Actin nucleation alliance: from yeast to human cells" on May 25, 2022, at 9:30 am, in-person in Kahn Auditorium (BSRB) and via live stream: Meeting Link: https://umich.zoom.us/j/92937676014

Hosted By:
Ryoma Ohi, Ph.D.
Lois Weisman, Ph.D.

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Livestream / Virtual Fri, 22 Apr 2022 15:45:11 -0400 2022-05-25T09:30:00-04:00 2022-05-25T10:30:00-04:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Livestream / Virtual Actin nucleation alliance: from yeast to human cells
Charlie Doering Memorial Symposium (May 26, 2022 9:15am) https://events.umich.edu/event/94993 94993-21788226@events.umich.edu Event Begins: Thursday, May 26, 2022 9:15am
Location: Rackham Graduate School (Horace H.)
Organized By: The Center for the Study of Complex Systems

WEBINAR JOIN LINK https://umich.zoom.us/j/93305911598
(registration not required)

This will be a hybrid event held at Rackham 4th floor (Charlie loved this space!). The first day of the symposium will be Thursday May 26 and will start with mainly fluid dynamics talks which will switchover in the afternoon to more stochastics related talks. Thursday's talks will end at 4:00pm on and will be followed by a Celebration of Life from 4:15-6:30pm. The Symposium will continue into Friday with stochastics related topics and will end at 1:00pm.

Covid protocols will be in place and Covid tests will be available to guests, as well as masks.

ZOOM WEBINAR LINK will be emailed to registrants.

REGISTER: https://docs.google.com/forms/d/e/1FAIpQLSduEP2ufk7blPu3w3BYMUT74SilyCX3ee9orhnGEH45vKZnIQ/viewform

CONFERENCE WEBSITE: https://sites.lsa.umich.edu/charlie-doering-symposium/
See conference website for talk titles, full speaker bios

SCHEDULE

Day 1 - May 26

9:30 AM Coffee/pastries
9:55 AM Opening remarks Marisa Eisenberg
10:00 AM Fluid dynamics Jean-Luc Thiffeault
10:50 AM Fluid dynamics John Gibbon (REMOTE)
11:40 AM Fluid dynamics Darryl Holm (REMOTE)

12:30 PM Lunch (at venue or on own)

1:30 PM Fluid dynamics/stochastics Ian Tobasco
2:20 PM Fluid dynamics/stochastics Daniel Lathrop
3:10 PM Fluid dynamics/stochastics Annette Ostling

4:00 PM 0:15 Break

4:15 PM - 6:30 PM Celebration of Life Assembly Hall - Rackham

Day 2 - May 27

9:30 AM Coffee/pastries

10:00 AM Stochastics/other Sid Redner
10:50 AM Break - 20 minutes
11:10 AM Stochastics/other Len Sander
12:00 PM Stochastics/other Nikola Petrov

12:50 PM CLOSE OF SYMPOSIUM

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Conference / Symposium Thu, 26 May 2022 08:57:55 -0400 2022-05-26T09:15:00-04:00 2022-05-26T16:00:00-04:00 Rackham Graduate School (Horace H.) The Center for the Study of Complex Systems Conference / Symposium Gameday Charlie
Charlie Doering Memorial Symposium (May 27, 2022 9:15am) https://events.umich.edu/event/94993 94993-21788227@events.umich.edu Event Begins: Friday, May 27, 2022 9:15am
Location: Rackham Graduate School (Horace H.)
Organized By: The Center for the Study of Complex Systems

WEBINAR JOIN LINK https://umich.zoom.us/j/93305911598
(registration not required)

This will be a hybrid event held at Rackham 4th floor (Charlie loved this space!). The first day of the symposium will be Thursday May 26 and will start with mainly fluid dynamics talks which will switchover in the afternoon to more stochastics related talks. Thursday's talks will end at 4:00pm on and will be followed by a Celebration of Life from 4:15-6:30pm. The Symposium will continue into Friday with stochastics related topics and will end at 1:00pm.

Covid protocols will be in place and Covid tests will be available to guests, as well as masks.

ZOOM WEBINAR LINK will be emailed to registrants.

REGISTER: https://docs.google.com/forms/d/e/1FAIpQLSduEP2ufk7blPu3w3BYMUT74SilyCX3ee9orhnGEH45vKZnIQ/viewform

CONFERENCE WEBSITE: https://sites.lsa.umich.edu/charlie-doering-symposium/
See conference website for talk titles, full speaker bios

SCHEDULE

Day 1 - May 26

9:30 AM Coffee/pastries
9:55 AM Opening remarks Marisa Eisenberg
10:00 AM Fluid dynamics Jean-Luc Thiffeault
10:50 AM Fluid dynamics John Gibbon (REMOTE)
11:40 AM Fluid dynamics Darryl Holm (REMOTE)

12:30 PM Lunch (at venue or on own)

1:30 PM Fluid dynamics/stochastics Ian Tobasco
2:20 PM Fluid dynamics/stochastics Daniel Lathrop
3:10 PM Fluid dynamics/stochastics Annette Ostling

4:00 PM 0:15 Break

4:15 PM - 6:30 PM Celebration of Life Assembly Hall - Rackham

Day 2 - May 27

9:30 AM Coffee/pastries

10:00 AM Stochastics/other Sid Redner
10:50 AM Break - 20 minutes
11:10 AM Stochastics/other Len Sander
12:00 PM Stochastics/other Nikola Petrov

12:50 PM CLOSE OF SYMPOSIUM

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Conference / Symposium Thu, 26 May 2022 08:57:55 -0400 2022-05-27T09:15:00-04:00 2022-05-27T13:00:00-04:00 Rackham Graduate School (Horace H.) The Center for the Study of Complex Systems Conference / Symposium Gameday Charlie
MCDB Defense> Shared Regulators of Axon Degeneration and Synaptic Structure (May 27, 2022 10:00am) https://events.umich.edu/event/95159 95159-21788709@events.umich.edu Event Begins: Friday, May 27, 2022 10:00am
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Mentor: Catherine Collins

1010 BSB
Also zoom: https://umich.zoom.us/j/96367280934
Password in MCDB weekly update
or email: mcdb.seminar.info@umich.edu

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Workshop / Seminar Mon, 16 May 2022 21:28:13 -0400 2022-05-27T10:00:00-04:00 2022-05-27T11:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow MCDB initials and microscope on a blue background
BMS-Michigan Symposium (May 27, 2022 12:00pm) https://events.umich.edu/event/95138 95138-21788507@events.umich.edu Event Begins: Friday, May 27, 2022 12:00pm
Location: Off Campus Location
Organized By: Department of Chemistry

Organic
Kami Hull(University of Texas) , Julia Kalow(Northwestern University) , Eric Simmons(Bristol Myers Squibb)

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Other Fri, 27 May 2022 18:15:07 -0400 2022-05-27T12:00:00-04:00 2022-05-27T17:00:00-04:00 Off Campus Location Department of Chemistry Other
EEB Special Seminar: "Insights from phenotype x genotype x environment interactions in species-specific functional traits in non-model systems" (June 2, 2022 2:00pm) https://events.umich.edu/event/95336 95336-21789190@events.umich.edu Event Begins: Thursday, June 2, 2022 2:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

ABSTRACT: Untangling the interaction between genotype, environment, and phenotype represents a central goal of evolutionary biology, yet a comprehensive understanding of the relative influence of each remains elusive, especially in non-model systems. My research uses several approaches for investigating the multiple sources of variation that can impact observed phenotypic traits. I highlight how functional traits impacting dispersal ability in Caribbean mangrove species, when coupled with spatially explicit ocean current data, can lead to crucial insights about how genetic variation was shaped by the environment. Especially in periods of rapid climate change, environmental pressures can impact the adaptive nature of traits, and in some cases, adaptive variation can transcend species boundaries. Using a case of recent (i.e., Pleistocene) hybridization in montane sedges, I illustrate how genotype-environment association analyses identify adaptive loci with respect to environmental gradients that overwhelmingly correspond to loci with excess ancestry from one parental lineage. Digitized museum specimens may represent an efficient way to study the interaction of genome, phenome, and environment; I propose an analytical framework for explicitly quantifying the covariation of genomic, phenotypic, and environmental data from thousands of conspecific specimens.

SPEAKER'S WEBSITE: https://richiehodel.com/

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Lecture / Discussion Fri, 27 May 2022 11:19:37 -0400 2022-06-02T14:00:00-04:00 2022-06-02T16:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Lecture / Discussion EEB Special Seminar poster with images of interrelation of environment, phenotype and genotype
7th Annual Gilbert S. Omenn, MD, PhD Lecture (June 3, 2022 10:00am) https://events.umich.edu/event/95013 95013-21788268@events.umich.edu Event Begins: Friday, June 3, 2022 10:00am
Location: Off Campus Location
Organized By: Omenn Lecture

Talk Title: Biomedical Data Science: The Hope, Hype, and Promise

Abstract: Data science was introduced as a “new” profession in the early 1960s, yet the Office of Data Science Strategy at the National Institutes of Health (NIH) was not established until 2018. Artificial intelligence (AI) traces its roots to at least the 1950s, with its first application as an expert system in medicine in the early 1970s. Yet, the NIH Working Group on AI was not established until 2018 as well, with their first report issued in 2019. This is not to say that these topics have been neglected over the past half-century, but it begs the question of why have they only now come to the forefront of biomedicine? We have seen multiple AI booms and busts, each of which has caused massive hype, dream crushing failures, and notable advancements (some more flashy than others) along the way. This talk is not intended to be a history lesson, but it will provide some context for how we got to where we are and what this says about where biomedical research and healthcare seems to be heading. I will further provide insight into how various innovations in computation, policy, and industry have pushed the field forward and where recently established programs to expand AI activities, such as AIM-AHEAD and Bridge2AI, may push the biomedical research community over the next decade. To ground this presentation, I will provide examples of how AI and data science more generally have driven activities at the All of Us Research Program and the Vanderbilt Health Data Science Center.

Short Bio: Bradley Malin is the Vice Chair for Research in the Department of Biomedical Informatics at Vanderbilt University Medical Center and is the Accenture Professor of Biomedical Informatics, Biostatistics, and Computer Science at Vanderbilt University. He founded and co-directs the Vanderbilt Health Data Science Center, as well as the Center for Genetic Privacy and Identity in Community Settings (GetPreCiSe), the latter of which is an NIH Center of Excellence in Ethical, Legal, and Social Implications Research. Since 2007, he has chaired the Committee on Access, Privacy, and Security (CAPS) for the NIH-sponsored All of Us Research Program and, in 2021, he became one of the founding PIs of the NIH Artificial Intelligence/Machine Learning Consortium to Advance Health Equity and Researcher Diversity (AIM-AHEAD). He serves on various governmental advisory bodies, including the Board of Scientific Counselors of the National Center for Health Statistics (NCHS) of the U.S. Centers for Disease Control and Medicine (CDC). He was honored as a Presidential Early Career Award for Scientists and Engineers (PECASE) and is an elected member of the National Academy of Medicine (NAM), the American College of Medical Informatics (ACMI), the American Institute for Medical and Biological Engineering (AIMBE), and the International Academy of Health Sciences Informatics (IAHSI) . He received a B.S. in Biological Sciences, M.S. in Machine Learning, M.Phil. in Public Policy and Management, and Ph.D. in Computer Science, all from Carnegie Mellon University.

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Lecture / Discussion Fri, 06 May 2022 12:03:12 -0400 2022-06-03T10:00:00-04:00 2022-06-03T11:00:00-04:00 Off Campus Location Omenn Lecture Lecture / Discussion Bradley Malin, PhD
7th Annual Gilbert S. Omenn, MD, PhD Lecture (June 3, 2022 10:00am) https://events.umich.edu/event/95013 95013-21789263@events.umich.edu Event Begins: Friday, June 3, 2022 10:00am
Location: Off Campus Location
Organized By: Omenn Lecture

Talk Title: Biomedical Data Science: The Hope, Hype, and Promise

Abstract: Data science was introduced as a “new” profession in the early 1960s, yet the Office of Data Science Strategy at the National Institutes of Health (NIH) was not established until 2018. Artificial intelligence (AI) traces its roots to at least the 1950s, with its first application as an expert system in medicine in the early 1970s. Yet, the NIH Working Group on AI was not established until 2018 as well, with their first report issued in 2019. This is not to say that these topics have been neglected over the past half-century, but it begs the question of why have they only now come to the forefront of biomedicine? We have seen multiple AI booms and busts, each of which has caused massive hype, dream crushing failures, and notable advancements (some more flashy than others) along the way. This talk is not intended to be a history lesson, but it will provide some context for how we got to where we are and what this says about where biomedical research and healthcare seems to be heading. I will further provide insight into how various innovations in computation, policy, and industry have pushed the field forward and where recently established programs to expand AI activities, such as AIM-AHEAD and Bridge2AI, may push the biomedical research community over the next decade. To ground this presentation, I will provide examples of how AI and data science more generally have driven activities at the All of Us Research Program and the Vanderbilt Health Data Science Center.

Short Bio: Bradley Malin is the Vice Chair for Research in the Department of Biomedical Informatics at Vanderbilt University Medical Center and is the Accenture Professor of Biomedical Informatics, Biostatistics, and Computer Science at Vanderbilt University. He founded and co-directs the Vanderbilt Health Data Science Center, as well as the Center for Genetic Privacy and Identity in Community Settings (GetPreCiSe), the latter of which is an NIH Center of Excellence in Ethical, Legal, and Social Implications Research. Since 2007, he has chaired the Committee on Access, Privacy, and Security (CAPS) for the NIH-sponsored All of Us Research Program and, in 2021, he became one of the founding PIs of the NIH Artificial Intelligence/Machine Learning Consortium to Advance Health Equity and Researcher Diversity (AIM-AHEAD). He serves on various governmental advisory bodies, including the Board of Scientific Counselors of the National Center for Health Statistics (NCHS) of the U.S. Centers for Disease Control and Medicine (CDC). He was honored as a Presidential Early Career Award for Scientists and Engineers (PECASE) and is an elected member of the National Academy of Medicine (NAM), the American College of Medical Informatics (ACMI), the American Institute for Medical and Biological Engineering (AIMBE), and the International Academy of Health Sciences Informatics (IAHSI) . He received a B.S. in Biological Sciences, M.S. in Machine Learning, M.Phil. in Public Policy and Management, and Ph.D. in Computer Science, all from Carnegie Mellon University.

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Lecture / Discussion Fri, 06 May 2022 12:03:12 -0400 2022-06-03T10:00:00-04:00 2022-06-03T11:00:00-04:00 Off Campus Location Omenn Lecture Lecture / Discussion Bradley Malin, PhD
MCDB Defense> Mechanistic Insight Into the Role of Gut Bacterial Functional Amyloids in Modulating α-synuclein Aggregation (June 3, 2022 10:00am) https://events.umich.edu/event/95391 95391-21789883@events.umich.edu Event Begins: Friday, June 3, 2022 10:00am
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Mentor: Matthew Chapman

Also hybrid. Check the weekly update or email: mcdb.seminar.info@umich.edu

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Workshop / Seminar Thu, 02 Jun 2022 14:22:24 -0400 2022-06-03T10:00:00-04:00 2022-06-03T11:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow initials MCDB and cartoon of a microscope on a blue background
MCDB Seminar> Evaluating Lipid Dysregulation, Infection, and Social Determinants of Health on Brain Metabolism. (June 3, 2022 12:00pm) https://events.umich.edu/event/94840 94840-21776802@events.umich.edu Event Begins: Friday, June 3, 2022 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Monica Dus

This event is now hybrid. Please join us in BSB 1060 in person if possible.

Zoom details:
https://umich.zoom.us/j/97318271010
passcode available by emailing mcdb.seminar.info@umich.edu

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Workshop / Seminar Thu, 02 Jun 2022 13:39:50 -0400 2022-06-03T12:00:00-04:00 2022-06-03T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow initials MCDB and cartoon of a microscope on a blue background
RNA Innovation Seminar: "Long non-coding RNAs as evolutionarily fluid chromatin weavers" (June 6, 2022 4:00pm) https://events.umich.edu/event/92839 92839-21697184@events.umich.edu Event Begins: Monday, June 6, 2022 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

HYBRID SEMINAR:
In-person: BSRC, ABC seminar rooms
Zoom: https://umich.zoom.us/webinar/register/WN_3ga-wcUYSgqPEKw57DSfpg

Talk title: "Long non-coding RNAs as evolutionarily fluid chromatin weavers"

Keywords: lncRNAs, Genomics, Genome topology

Abstract: Long non-coding RNAs (lncRNAs) have recently emerged as prominent elements of the regulatory transactions of eukaryotic genomes. Many of the know regulatory functions of lncRNAs in both animals and plants rely on the rearrangement of chromatin through direct interactions or recruitment of chromatin-modifying elements. In this talk, I will discuss the difficulty in identifying evolutionary conservation in lncRNAs, and how we characterize these evolutionarily volatile elements in the context of their role as regulators of the three-dimensional conformation of nuclear chromatin. I will focus on our findings resulting from the concurrent characterization of transcripts, tridimensional chromatin structure and direct RNA-DNA interactions in closely related plant species. I will also discuss how such techniques have vast potential to illuminate biomedically relevant lncRNAs when analyzed from a comparative genomics perspective.

If you are having trouble registering, please contact Martina Jerant at mjerant@umich.edu

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Lecture / Discussion Wed, 20 Apr 2022 10:16:03 -0400 2022-06-06T16:00:00-04:00 2022-06-06T17:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion Selene L. Fernandez-Valverde, Advanced Genomics Unit, LANGEBIO, Cinvestav
EEB Thesis Defense: Novel DNA mycovirus BdDV-1 alters the phenotype of amphibian pathogen batrachochytrium dendrobatidis (June 7, 2022 2:00pm) https://events.umich.edu/event/95384 95384-21789257@events.umich.edu Event Begins: Tuesday, June 7, 2022 2:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Please reach out to the department for the zoom link

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Lecture / Discussion Thu, 02 Jun 2022 08:29:17 -0400 2022-06-07T14:00:00-04:00 2022-06-07T16:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Lecture / Discussion Poster advertising a thesis defense featuring a jumping frog
“Genetic regulation of epithelial homeostasis and injury” (June 7, 2022 4:00pm) https://events.umich.edu/event/95318 95318-21789154@events.umich.edu Event Begins: Tuesday, June 7, 2022 4:00pm
Location:
Organized By: Center for Cell Plasticity and Organ Design

The NIH T32 Training Program in Organogenesis trainees are please to present a Special Series, "Building and Rebuilding: Regulation of Cell Signaling in Development and Regeneration," featuring guest speaker, Adam D. Gracz, PhD.

Dr. Gracz is an Assistant Professor of Medicine-Division of Digestive Disease at Emory University.

The talk is entitled, “Genetic regulation of epithelial homeostasis
and injury.”

Trainee Host
Megan Radyk, PhD-Lyssiotis & Shah Labs

For more information email: Organogenesis@umich.edu

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Lecture / Discussion Thu, 26 May 2022 10:58:57 -0400 2022-06-07T16:00:00-04:00 2022-06-07T17:00:00-04:00 Center for Cell Plasticity and Organ Design Lecture / Discussion Gracz flyer
Dynamic and thermodynamic performance bounds for collective motor-driven transport (June 14, 2022 11:00am) https://events.umich.edu/event/95348 95348-21789211@events.umich.edu Event Begins: Tuesday, June 14, 2022 11:00am
Location: Weiser Hall
Organized By: The Center for the Study of Complex Systems

This seminar will be in-person only.

Abstract: Motor-driven intracellular transport of organelles, vesicles, and other molecular cargo is a highly collective process. An individual cargo is often pulled by a team of molecular motors, with numbers ranging from only a few to several hundred. Using stochastic thermodynamics, we derive a series of bounds that constrain the performance (including velocity, precision, and efficiency) of a broad class of these collective-transport systems for arbitrary number of motors. We then explore an analytically tractable model that gives simple functional forms for the performance metrics and exactly saturates the derived bounds. The resulting trade-offs with varying motor number point to design principles governing functional collections of transport motors in different contexts.

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Workshop / Seminar Tue, 31 May 2022 17:37:01 -0400 2022-06-14T11:00:00-04:00 2022-06-14T12:30:00-04:00 Weiser Hall The Center for the Study of Complex Systems Workshop / Seminar David Sivak
BIBC Research Seminar (June 16, 2022 4:00pm) https://events.umich.edu/event/95344 95344-21789201@events.umich.edu Event Begins: Thursday, June 16, 2022 4:00pm
Location: North Campus Research Complex Building 10
Organized By: BioInnovations in Brain Cancer

Please join us to hear from trainees conducting brain cancer and technology-related research. This is part of a special summer seminar series that will be followed by a BIBC sponsored social hour.

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Workshop / Seminar Tue, 31 May 2022 13:31:27 -0400 2022-06-16T16:00:00-04:00 2022-06-16T17:00:00-04:00 North Campus Research Complex Building 10 BioInnovations in Brain Cancer Workshop / Seminar BIBC June Seminar Flyer
MCDB Seminar> Control of the Anti-viral Response Through Spatial Re-localization of an RNA Phosphatase (June 17, 2022 12:00pm) https://events.umich.edu/event/94841 94841-21776803@events.umich.edu Event Begins: Friday, June 17, 2022 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Hosts: Monica Dus & Morgan DeSantis

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Workshop / Seminar Mon, 13 Jun 2022 11:14:07 -0400 2022-06-17T12:00:00-04:00 2022-06-17T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow initials MCDB and cartoon of a microscope on a blue background
Juneteenth Seminar (June 20, 2022 12:00pm) https://events.umich.edu/event/95563 95563-21790156@events.umich.edu Event Begins: Monday, June 20, 2022 12:00pm
Location: Off Campus Location
Organized By: Department of Chemistry

Analytical
Renã Robinson (Vanderbilt University)

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Other Mon, 20 Jun 2022 18:15:09 -0400 2022-06-20T12:00:00-04:00 2022-06-20T13:15:00-04:00 Off Campus Location Department of Chemistry Other
LHS Collaboratory (June 21, 2022 12:00pm) https://events.umich.edu/event/95245 95245-21789057@events.umich.edu Event Begins: Tuesday, June 21, 2022 12:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

"Restructuring health systems for learning: Building equity into the Learning Health System"
Learn more about ELSI-LHS (Ethical, Legal, and Social Implications of Learning Health Systems). The session will be moderated by, Jody E. Platt, MPH, PhD, Assistant Professor of Learning Health Sciences.

Speaker:
Lauren A. Taylor, PhD, MDiv, MPH
Assistant Professor
Department of Population Health
Division of Medical Ethics
NYU Grossman School of Medicine

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Lecture / Discussion Wed, 25 May 2022 00:20:49 -0400 2022-06-21T12:00:00-04:00 2022-06-21T13:00:00-04:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion LHS Collaboratory logo
Understanding Genetic Factors that Modulate Hedgehog-Driven Skin Cancer (June 21, 2022 1:00pm) https://events.umich.edu/event/95720 95720-21790785@events.umich.edu Event Begins: Tuesday, June 21, 2022 1:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

Dissertation Defense

We are pleased to welcome Kenny Trieu, Ph.D. candidate, to the ABC Seminar Rooms in BSRB on June 27, 2022, to present his talk titled “Understanding Genetic Factors that Modulate Hedgehog-Driven Skin Cancer.”

Professor Andrzej A. Dlugosz, Chair
Associate Professor Sunny Y. Wong, Mentor
Professor Pierre A. Coulombe
Associate Professor David B. Lombard
Associate Professor Xing Fan.

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Lecture / Discussion Tue, 21 Jun 2022 13:08:38 -0400 2022-06-21T13:00:00-04:00 2022-06-21T14:00:00-04:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion Understanding Genetic Factors that Modulate Hedgehog-Driven Skin Cancer
MCDB Seminar> Regulation of axon stability by axoglial metabolic coupling (June 24, 2022 12:00pm) https://events.umich.edu/event/94943 94943-21786537@events.umich.edu Event Begins: Friday, June 24, 2022 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Ken Cadigan

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Workshop / Seminar Mon, 20 Jun 2022 11:09:24 -0400 2022-06-24T12:00:00-04:00 2022-06-24T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow initials MCDB and cartoon of a microscope on a blue background
Collagen COL-75 induces ER unfolded protein response cell non-autonomously (July 6, 2022 2:00pm) https://events.umich.edu/event/95721 95721-21790786@events.umich.edu Event Begins: Wednesday, July 6, 2022 2:00pm
Location: Off Campus Location
Organized By: Cell & Developmental Biology

Dissertation Defense

We are pleased to announce that Titan Shih, Ph.D. candidate, will present his Dissertation Defense on "Collagen COL-75 induces ER unfolded protein response cell non-autonomously" virtually on Wednesday, July 6, 2022, 2:00 p.m.-3:00 p.m.

Hosted By the Dissertation Committee:
Benjamin Allen, Ph.D. - Co-mentor
Marina Pasca di Magliano, Ph.D. - Co-mentor
Andrzej Dlugosz, M.D. - Chair
Deneen Wellik, Ph.D.
Howard Crawford, Ph.D.

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Livestream / Virtual Tue, 21 Jun 2022 13:50:11 -0400 2022-07-06T14:00:00-04:00 2022-07-06T15:00:00-04:00 Off Campus Location Cell & Developmental Biology Livestream / Virtual Collagen COL-75 induces ER unfolded protein response cell non-autonomously
Targeting cancer cell stress tolerance and drug resistance (July 7, 2022 9:00am) https://events.umich.edu/event/95711 95711-21790766@events.umich.edu Event Begins: Thursday, July 7, 2022 9:00am
Location: Palmer Commons
Organized By: Cell & Developmental Biology

We are pleased to welcome David Cheresh, Ph.D. to Forum Hall in Palmer Commons on Thursday, July 7, 2022, to present his talk titled "Targeting cancer cell stress tolerance and drug resistance"

Hosted By:
U-M Life Sciences Institute
Department of Cell & Developmental Biology, Medical School
Faculty Host: Stephen J. Weiss, M.D.

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Lecture / Discussion Tue, 28 Jun 2022 12:53:49 -0400 2022-07-07T09:00:00-04:00 2022-07-07T10:00:00-04:00 Palmer Commons Cell & Developmental Biology Lecture / Discussion Targeting cancer cell stress tolerance and drug resistance
MCDB Seminar> Structural Insights into Clathrin Mediated Endocytosis (July 8, 2022 12:00pm) https://events.umich.edu/event/94944 94944-21786538@events.umich.edu Event Begins: Friday, July 8, 2022 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Morgan Desantis

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Workshop / Seminar Mon, 16 May 2022 13:17:02 -0400 2022-07-08T12:00:00-04:00 2022-07-08T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow initials MCDB and cartoon of a microscope on a blue background
MCDB Seminar> The role of airway epithelial cells in sensing external assaults and internal state (July 15, 2022 12:00pm) https://events.umich.edu/event/94945 94945-21786539@events.umich.edu Event Begins: Friday, July 15, 2022 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Josie Clowney

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Workshop / Seminar Fri, 08 Jul 2022 10:55:18 -0400 2022-07-15T12:00:00-04:00 2022-07-15T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow initials MCDB and cartoon of a microscope on a blue background
EEB Dissertation Defense: Diversification in the Unionidae: Investigating the role of parasitism (July 21, 2022 11:00am) https://events.umich.edu/event/95512 95512-21790024@events.umich.edu Event Begins: Thursday, July 21, 2022 11:00am
Location: Rackham Graduate School (Horace H.)
Organized By: Ecology and Evolutionary Biology

In addition to in-person, there will be a Zoom link. Please reach out to eeb.gradcoord@umich.edu at least two hours in advance for the link.

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Lecture / Discussion Thu, 07 Jul 2022 08:42:17 -0400 2022-07-21T11:00:00-04:00 2022-07-21T13:00:00-04:00 Rackham Graduate School (Horace H.) Ecology and Evolutionary Biology Lecture / Discussion EEB superimposed over leaves, a rodent, an amphibian and a bird
Discovery and Development of Agonist Antibodies for T Cell Receptors (July 29, 2022 10:00am) https://events.umich.edu/event/96254 96254-21792188@events.umich.edu Event Begins: Friday, July 29, 2022 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

Agonist antibodies that activate co-stimulatory immune receptors, such as the tumor necrosis factor (TNF) receptors OX40 and CD137, are an important class of emerging therapeutics due to their ability to regulate immune cell activity. Despite their promise, there are no approved agonist antibodies for treating cancer as demonstrated by previous unsuccessful clinical trials. Although multiple factors are responsible for poor clinical efficacy, one major bottleneck is the reliance on FcγR-mediated crosslinking for sufficient receptor activation. This is inherently problematic because FcγR expression varies greatly on different immune cells, leading to a wide range of receptor agonism. Emerging research suggests that antibodies engaging two different epitopes on the same immune receptor mediate receptor superclustering and enable robust antibody agonism without extrinsic Fc crosslinking. However, there are no systematic methods for identifying such biepitopic (also known as biparatopic) agonist antibodies. Therefore, the objective of this research work is to develop facile methods for reliably identifying biepitopic antibodies to activate immune receptors for immunotherapeutic applications.

Biepitopic antibodies have been shown to mediate potent receptor activation for a variety of immune receptors. Traditionally, the generation of these antibodies requires key steps including animal immunization, epitope binning to identify unique antibody pairs, and combining antibody pairs to engineer biepitopic antibodies. While this approach has been used to successfully discover biepitopic antibodies, it suffers from key limitations. Notably, animal immunization and subsequent antibody isolation is an arduous and unpredictable process. Even when successful clones are discovered from these processes, further epitope binning experiments are needed to select antibody pairs to discover potent immune therapeutics. To overcome these limitations, we developed an antibody screening strategy that greatly simplifies the discovery of biepitopic antibodies. Our approach eliminates the need for animal immunization by using existing, off-the-shelf IgG antibodies specific to the target receptor. Next, we perform in vitro selections by blocking the receptor epitope of the existing antibody and conducting subsequent sorts to identify single-chain antibodies with orthogonal binding domains. Thus far, our work has shown that the antibody screening strategy can be used to discover antibodies for a variety of TNF receptors including OX40 and CD137.

Given that receptor clustering of three or more receptors is critical for activating TNF receptors, we first generated biepitopic tetravalent OX40 antibodies by attaching novel single-chain antibodies to the C-termini of the light chain of existing clinical-stage antibodies. These tetravalent biepitopic antibodies showed remarkable T cell proliferation and cytokine secretion for biepitopic antibodies compared to their monoepitopic counterparts. Next, we sought to improve the additional clinical-stage OX40 IgGs engineered as biepitopic antibodies to show the generality of our findings that biepitopic antibodies can mediate superior and FcγR-independent activities. Beyond OX40 IgGs, we also show that biepitopic antibodies can be used to mediate superior T cell proliferation for other TNF receptors including CD137. Looking forward, we anticipate that these research advancements will accelerate the discovery and development of the next generation of immune therapeutics.

Date: Friday, July 29, 2022
Time: 10:00 AM
Zoom: https://umich.zoom.us/j/5163583658
Co-Chairs: Professors Peter Tessier and Lonnie Shea

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Lecture / Discussion Tue, 26 Jul 2022 13:09:39 -0400 2022-07-29T10:00:00-04:00 2022-07-29T11:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Ph.D. Defense
MCDB Seminar> Discovering Chemical Probes of DNAJB6: A Novel Target for Polyglutamine Diseases (July 29, 2022 12:00pm) https://events.umich.edu/event/95306 95306-21789142@events.umich.edu Event Begins: Friday, July 29, 2022 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Anuj Kumar

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Workshop / Seminar Tue, 07 Jun 2022 11:33:26 -0400 2022-07-29T12:00:00-04:00 2022-07-29T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow initials MCDB and cartoon of a microscope on a blue background
MCDB Defense> Decision-making in ubiquitin-based cellular decluttering (August 8, 2022 10:00am) https://events.umich.edu/event/96490 96490-21792587@events.umich.edu Event Begins: Monday, August 8, 2022 10:00am
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Mentor: Ming Li

Hybrid event:
email: mcdb.seminar.info@umich.edu for link and password or check weekly update

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Workshop / Seminar Thu, 04 Aug 2022 11:24:58 -0400 2022-08-08T10:00:00-04:00 2022-08-08T11:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials and cartoon microscope
MCDB Seminar> Resistance, Resilience, and Reconciliation: Lessons from plant genetics (August 8, 2022 11:00am) https://events.umich.edu/event/96367 96367-21792359@events.umich.edu Event Begins: Monday, August 8, 2022 11:00am
Location: Undergraduate Science Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: MCDB

Monday August 8, 11 am
Undergraduate Science Building Room 1230

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Workshop / Seminar Mon, 01 Aug 2022 11:33:49 -0400 2022-08-08T11:00:00-04:00 2022-08-08T12:00:00-04:00 Undergraduate Science Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow initials MCDB and cartoon of a microscope on a blue background
MCDB Seminar> Signal sensing and integration by plant cell surface receptors (August 8, 2022 12:00pm) https://events.umich.edu/event/96366 96366-21792357@events.umich.edu Event Begins: Monday, August 8, 2022 12:00pm
Location: Undergraduate Science Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: MCDB

Note: unusual time and location
Monday August 8
Undergraduate Science Building

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Workshop / Seminar Mon, 01 Aug 2022 11:29:50 -0400 2022-08-08T12:00:00-04:00 2022-08-08T13:00:00-04:00 Undergraduate Science Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow MCDB initials and Microscope drawing on blue
MCDB Defense> Transcription Factor Interactions Governing Gene Regulation by the Wnt Signalling Pathway (August 10, 2022 11:00am) https://events.umich.edu/event/96491 96491-21792590@events.umich.edu Event Begins: Wednesday, August 10, 2022 11:00am
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Mentor: Ken Cadigan

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Workshop / Seminar Thu, 04 Aug 2022 11:59:04 -0400 2022-08-10T11:00:00-04:00 2022-08-10T12:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials and cartoon microscope on blue rectangle
Effects of Electric Stimulation on Physiology and Anatomy of the Visual Pathway (August 10, 2022 12:00pm) https://events.umich.edu/event/96539 96539-21792637@events.umich.edu Event Begins: Wednesday, August 10, 2022 12:00pm
Location:
Organized By: Biomedical Engineering

Abstract:
Retinal degenerative diseases that progressively lead to severe blindness impact the affected individual’s quality-of-life. Visual prosthesis technology aims to provide an individual a potential means of obtaining visual information lost to them by blindness. Since the proof-of-concept success in 1968 of a device implanted in a human, visual prostheses have had sustained academic research and commercial interest. However, commercial failure of two retinal prosthesis device has raised concerns for the visual prosthesis field. To learn from this experience, research in this dissertation is aimed at understanding the impact of electric stimulation on the target neural tissue and investigating technology for a visual cortex prosthesis, which can reach a larger patient population (compared to a retinal prosthesis).

My first set of experiments assessed, in an animal model of retinal degeneration, the condition of the brain and its ability to receive artificial vision information. Retinitis Pigmentosa has been proven to impact the human brain. My study investigated the extent to which this was replicated in a rat animal model of a single genetic mutation of Retinitis Pigmentosa. The P23H-1 rat was investigated with electrophysiology and immunohistochemistry to understand the brain’s function and structural condition. The rat brain’s response to light and electric stimulation was investigated, and the change of visually evoked responses and maintenance of electrically evoked responses was observed. Histology images show a relatively stable macrostructure of the blind rat brain.

I also performed retinal and cortical implant procedures to test newly developed visual prosthesis technology to enable investigations into researching neural change occurring from blindness and electric stimulation. A retinal device with Parylene-C as its main component was tested and its feasibility in the small eye of a rat animal model was investigated. The device can survive 4-weeks of implantation and is stable within the eye. In support of the development of a novel cortical visual prosthesis device that fits the need of blind individuals, I used a small animal model first to prove the efficacy and safety of a novel neurostimulation electrode. The device, named StiMote, is in preclinical development. I worked to characterize the full ability of the neural interface, High-Density Carbon Fibers with electrodeposited Platinum-Iridium. The ability of PtIr-HDCF as a recording and stimulation neural interface device was verified using electrochemical measurements before, during, and after a long-duration 7-hour electric stimulation session that simulates a full day of device use.

PtIr-HDCF as a neural interface device was verified by my previous work and its improvement in reducing neuroinflammatory response compared to other microelectrode array archetypes has been previously researched. As a result, PtIr-HDCF can be used as a device to monitor the brain and can better extract the effect of electric stimulation on the brain alone. I recorded neural electrophysiology to verify the rat brain’s sensitivity to stimuli before and after 7-hour stimulation. To supplement the already existing neural implant and electric stimulation inflammation data, Spatial Transcriptomics as a novel method to define electric stimulation safety was performed. Spatial Transcriptomics showed that PtIr-HDCF, when compared to a conventional microwire array, performs better in sustaining neural health by reducing neuroinflammation and eliciting mRNA upregulation of neurotrophic factors.

Findings of this project can be used to better inform future investigations into brain electrophysiology and transcriptomics projects aimed to understand the neural change from blindness and electric stimulation.

Committee Chair(s): Dr. James Weiland

Location: 1501 Auditorium, NCRC Bldg 32 & https://umich.zoom.us/j/91500987159?pwd=RWIvQkZVT2FHZjQ2S1BBS2k0ck1SUT09

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Lecture / Discussion Fri, 05 Aug 2022 10:32:21 -0400 2022-08-10T12:00:00-04:00 2022-08-10T13:00:00-04:00 Biomedical Engineering Lecture / Discussion BME Defense
Alum|NUM (August 11, 2022 9:00am) https://events.umich.edu/event/95038 95038-21788375@events.umich.edu Event Begins: Thursday, August 11, 2022 9:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Physical
TBA

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Other Thu, 11 Aug 2022 18:15:34 -0400 2022-08-11T09:00:00-04:00 2022-08-11T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Merck symposium 2022 (August 18, 2022 9:00am) https://events.umich.edu/event/96202 96202-21792034@events.umich.edu Event Begins: Thursday, August 18, 2022 9:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Physical
Christopher Vanderwal (UC-Irvine)

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Other Thu, 18 Aug 2022 18:15:32 -0400 2022-08-18T09:00:00-04:00 2022-08-18T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Hedgehog Signaling in the Olfactory Epithelium: Taking a Nosedive into the GLIs (August 24, 2022 10:00am) https://events.umich.edu/event/96783 96783-21793307@events.umich.edu Event Begins: Wednesday, August 24, 2022 10:00am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

We are pleased to announce that Anna Shirazyan, Ph.D. candidate, will present her Dissertation Defense on "Hedgehog Signaling in the Olfactory Epithelium: Taking a Nosedive into the GLIs" on Wednesday, August 24, 2022, from 10:00-11:00a.m., via live stream: https://umich.zoom.us/j/99809893179 Passcode: CDB, and in Person at BSRB Kahn Auditorium.

Hosted by the Dissertation Committee:
Professor Benjamin Allen, Mentor
Associate Professor Sunny Y. Wong, Chair
Professor Charlotte Mistretta
Professor Andrzej Dlugosz
Associate Professor Bradley Goldstein

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Lecture / Discussion Thu, 18 Aug 2022 14:47:53 -0400 2022-08-24T10:00:00-04:00 2022-08-24T11:00:00-04:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion Hedgehog Signaling in the Olfactory Epithelium: Taking a Nosedive into the GLIs
Instrumentation Grants: S10s? MRIs? Help! (August 26, 2022 12:00pm) https://events.umich.edu/event/96328 96328-21792274@events.umich.edu Event Begins: Friday, August 26, 2022 12:00pm
Location: Off Campus Location
Organized By: OVPR Office of Research Development

Would your research program benefit from an expensive new instrument? Or do you need to upgrade outdated equipment? Would that equipment (that costs more than most houses) change what you can do in your lab? Not sure how to pull together grant applications to get all the new bells and whistles?

Research Development and Proposal Services (RDPS) will host a webinar on applying for major instrumentation grants. We will cover both the NIH S10 and NSF Major Research Instrumentation (MRI) funding mechanisms. Presenters Jill Jividen, PhD, and Rachel Wallace, PhD, will cover application requirements, best practices, common pitfalls, suggested timelines, and more, with plenty of time for questions and discussion.

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Livestream / Virtual Fri, 29 Jul 2022 11:29:11 -0400 2022-08-26T12:00:00-04:00 2022-08-26T13:30:00-04:00 Off Campus Location OVPR Office of Research Development Livestream / Virtual Closeup of microscope