Happening @ Michigan https://events.umich.edu/list/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. Data-driven Methods for Automated Assessment of Coronary Artery Disease (August 30, 2022 9:00am) https://events.umich.edu/event/97256 97256-21794237@events.umich.edu Event Begins: Tuesday, August 30, 2022 9:00am
Location: Lurie Robert H. Engin. Ctr
Organized By: Biomedical Engineering

Abstract:

The current gold standard for Coronary Artery Disease (CAD) diagnosis is X-ray angiography. Visual estimation can be subjective, therefore semi-automated software tools such as Quantitative Coronary Angiography (QCA) have been developed to quantify disease severity. Alternatively, functional metrics such as Fractional Flow Reserve (FFR) have demonstrated better diagnostic outcomes than anatomical assessment, but they are not widely used due to cost and risk. Ideally, quantitative and functional information could be derived directly from X-ray angiography images without the additional risks, time, and cost associated with performing FFR or QCA.

The goal of this project is to develop automated data-driven approaches for anatomical and functional quantification of disease severity using X-ray angiography images. To this end, we have developed algorithms for 1) automated coronary vessel segmentation, 2) stenosis detection and characterization, 3) 3D reconstruction of coronary anatomy, and 4) image-based flow extraction. These algorithms can be used in conjunction with computational fluid dynamics (CFD) modeling to assess the functional significance of disease.

We first present AngioNet, a neural network for coronary segmentation from X-ray angiography images. Conventional algorithms relying on thresholding or filtering cannot distinguish between the coronary vessels and the catheter used to inject the dye. AngioNet’s key innovation is an Angiographic Processing Network, or APN, which learns the best possible combination of pre-processing filters to improve segmentation performance. AngioNet demonstrates state-of-the-art segmentation accuracy (Dice score = 0.864) and does not segment the catheter in challenging cases where other neural networks fail.

Building upon AngioNet, we developed combination of neural networks and image processing algorithms to automatically localize, segment, and measure stenoses. This pipeline was able to measure stenosis diameter within 0.206±0.155mm or approximately 1 pixel of ground truth measurements from QCA. It is also the first automated pipeline to quantify rather than categorize disease severity.

Although measuring stenosis diameter in 2D images is useful, a more robust approach would be to measure diameters in the 3D coronary anatomy. Another advantage of the 3D coronary anatomy is that it can be used to perform CFD simulations of blood flow and compute functional metrics such as FFR. To this end, we developed a machine learning approach for automated 3D vessel reconstruction from a series of uncalibrated 2D X-ray angiography images. This approach is superior to projective geometry methods for 3D reconstruction due to their semi-automatic nature and reliance on accurate knowledge of input image acquisition angles. Our machine learning approach has demonstrated sub-pixel error in radius reconstruction (0.16±0.07mm) and 1% error in FFR computed in a reconstructed coronary tree.

In addition to the 3D coronary geometry, information about patient-specific flow or pressure is required to perform a hemodynamics simulation and compute FFR. We developed an algorithm that tracks vessel area in sequential frames of a segmented angiography series to estimate relative flow in each branch. We validated the algorithm in the simplest possible case, using a simulation of dye transport under steady flow conditions as the ground truth. On average, the difference in relative flow per branch was 5.15% for a healthy coronary tree and 3.68% in a coronary tree with stenosis.

We finally demonstrated the successes and limitations of the methods developed in this thesis by comparing computational FFR derived using the above algorithms against clinically measured FFR. The error between the calculated and clinically measured FFR was 0.1, corresponding to an 11% error.

Committee Chair(s):
Dr. C. Alberto Figueroa and Dr. Brahmajee K. Nallamothu

Zoom Link: https://umich.zoom.us/j/94364657250, Passcode: 390041 *Registration is required

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Workshop / Seminar Mon, 22 Aug 2022 16:54:04 -0400 2022-08-30T09:00:00-04:00 2022-08-30T10:00:00-04:00 Lurie Robert H. Engin. Ctr Biomedical Engineering Workshop / Seminar BME Defense Announcement
MIDAS Research Pitches and Welcome Social (September 6, 2022 2:00pm) https://events.umich.edu/event/97500 97500-21794661@events.umich.edu Event Begins: Tuesday, September 6, 2022 2:00pm
Location: Weiser Hall
Organized By: Michigan Institute for Data Science

Start the fall semester with this social event for the U-M data science and AI research community! Find out about exciting data science research that is happening at U-M, explore collaboration opportunities and student research opportunities. A number of junior faculty members and faculty new to U-M will each give a 3-minute lightning talk, and there will be ample networking time. Refreshments provided. All U-M faculty, staff and students are welcome to attend.

Register To Attend
https://forms.gle/JuRdZvV57bKpo4Ri9

Faculty Presenters (in alphabetical order):
Dr. Omar Ahmed
Assistant Professor, Psychology, LSA
Research Focus: Recording and analysis of massive volumes of neural data to understand, predict and treat neuropsychiatric disorders

Dr. Raed Al Kontar
Assistant Professor, Industrial & Operations Engineering, College of Engineering
Research Focus: Federated and distributed data analytics

Dr. Karen Alofs
Assistant Professor, School for Environment and Sustainability
Research Focus: Fish ecology and environmental change using historical data, museum specimens, field surveys, lab experiments and models

Dr. Lia Corrales
Assistant Professor, Astronomy, LSA
Research Focus: Data driven techniques for exoplanet detection in the NUV; data driven X-ray imaging techniques

Dr. Walter Dempsey
Assistant Professor, Biostatistics, School of Public Health
Research Focus: Data analytic methods in mobile and digital health

Dr. Ben Fish
Assistant Professor, Computer Science and Engineering, College of Engineering
Research Focus: Foundations of the social consequences of computing, particularly discrimination in machine learning

Dr. Edgar Franco Vivianco
Assistant Professor, Political Science, LSA
Research Focus: Handwritten text recognition models to analyze a corpus of interactions of Latin American colonial documents with the objective to analyze interactions of indigenous communities with the colonial state, the strategies they employed to resist exploitation, and their engagement with the legal system

Dr. Ben Green
Assistant Professor, Ford School of Public Policy
Research Focus: Design and ethics of government algorithms, with a focus on algorithmic fairness, human-algorithm interactions, and AI regulation

Dr. Amie Gordon
Assistant Professor, Psychology, LSA
Research Focus: Health and well-being in the context of close relationships utilizing experimental, observational, survey, dyadic, daily experience, longitudinal, and physiological methods.

Dr. Xun Huan
Assistant Professor, Mechanical Engineering, College of Engineering
Research Focus: Methods and algorithms of Bayesian computation and their applications in the areas of engineering and healthcare

Dr. Rahul Ladhania
Assistant Professor, School of Public Health
Research Focus: Machine Learning for causal inference in behavior science and public health

Dr. Brian Lin
Assistant Research Scientist, University of Michigan Transportation Research Institute (UMTRI), College of Engineering
Research Focus: Using data-driven methods to explore driver and vulnerable road user's behavior and interaction with automated vehicles

Dr. Anthony Million
Research Investigator, Inter-university Consortium for Political and Social Research (ICPSR), Institute for Social Research
Research Focus: Investigating if pre-registration systems need discipline-specific design features and what these features might be

Dr. Matthew VanEseltine
Assistant Research Scientist, Survey Research Center, Institute for Social Research
Research Focus: The science of science, team science, early careers in scientific research, gender and science, and open science with restricted data

Dr. Joshua Welch
Assistant Professor, Computational Medicine and Bioinformatics, Medicine
Research Focus: Machine learning for single-cell genomics

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Social / Informal Gathering Tue, 06 Sep 2022 11:13:53 -0400 2022-09-06T14:00:00-04:00 2022-09-06T16:00:00-04:00 Weiser Hall Michigan Institute for Data Science Social / Informal Gathering Networking
Making Sense of Mechanisms: Studies on Learning Organic Chemistry (September 8, 2022 4:00pm) https://events.umich.edu/event/95970 95970-21791508@events.umich.edu Event Begins: Thursday, September 8, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Learning is a difficult, multidimensional process; educators have a responsibility to be aware of our students’ learning progress and respond to that awareness in ways that further promote learning. For the Raker Research Group, we are focused on understanding how novices develop and use the language of organic chemistry, i.e. how learners come to make sense of reaction mechanisms. This broader outcome for our course requires the activation and integration of multiple concepts and skills that have been shown to be difficult for learners. The focus of our work is on foundational concepts including acidity and basicity, and nucleophiles and electrophiles in the context of studying how learners make sense of mechanisms. We develop rubrics to measure learning and evaluate instruction, and construct learning experiences that supplement and complement instruction. We have been successful in using our rubrics to develop computer-based scoring models to evaluate 20,000+ written reaction mechanism explanations across the undergraduate organic chemistry curriculum. For our Lewis acid–base scoring model, we have demonstrated that the model can be deployed in adaptative tutorials to provide and promote targeted learning. While our work has specifically focused on organic chemistry, implications of our work extend to all areas of chemistry: to provide meaningful learning experiences for our students, we must have good tools to measure learning and work to create experiences that better and best promote that learning. Thus, molecular orbital diagrams in inorganic chemistry, phase diagrams in physical chemistry, or enzyme-substrate kinetics in biochemistry, for example, all provide contexts in our courses for reflecting on and responding to learning that requires integration of concepts and skills similar to how we do chemistry.




Jeffrey Raker (University of South Florida)

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Other Thu, 08 Sep 2022 18:15:32 -0400 2022-09-08T16:00:00-04:00 2022-09-08T17:15:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
From molecules to development: biological timing and patterning (September 8, 2022 4:30pm) https://events.umich.edu/event/97913 97913-21795312@events.umich.edu Event Begins: Thursday, September 8, 2022 4:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Abstract:
Organisms from bacteria to humans employ complex biochemical or genetic oscillatory networks, termed biological clocks, to drive a wide variety of cellular and developmental processes for robust timing and patterning. Despite their complexity and diversity, many of these clocks share the same core architectures that are highly conserved from species to species, suggesting an essential role of network structures underlying clock functioning. The Yang lab, bridging biophysics and systems & synthetic biology, has integrated modeling with experiments in minimal cells and live embryos to elucidate universal physical mechanisms underlying the complex processes during development. In this talk, I will focus on our recent efforts in understanding the design and interaction of cellular clocks in cell cycles and embryonic developmental patterns. Computationally, we have identified network motifs, notably incoherent inputs, that universally enhance systems' robust performance. Experimentally, we developed a unique synthetic-cell system in microfluidic droplets to analyze circuits and functions of robustness and tunability. We also established single-cell assays of zebrafish embryos combined with biomechanics to analyze the role of energy and mechanical and biochemical signaling in spatiotemporal patterns.

Bio:
Qiong Yang received a Ph.D. in Physics from MIT in 2009 before joining the Department of Chemical and Systems Biology at Stanford University for postdoctoral research, supported by the Stanford Dean’s Postdoctoral Fellowship and a Damon Runyon Cancer Research Fellowship. She was appointed as an Assistant Professor in Biophysics at the University of Michigan in 2014 and was promoted to Associate Professor in 2022. Her research group is affiliated with the departments of Physics, Applied Physics, BME, Complex Systems, and Computational Medicine & Bioinformatics at UM. She has received awards including NSF CAREER, NIH MIRA, Sloan Fellowship, Elizabeth C. Crosby Award, and Class of 1923 Memorial Teaching Award.​​​​​​​

Zoom:
https://umich.zoom.us/j/91375430500

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Workshop / Seminar Thu, 01 Sep 2022 10:44:42 -0400 2022-09-08T16:30:00-04:00 2022-09-08T17:30:00-04:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar BME 500 Seminar
Science Communication Certificate Program (September 12, 2022 12:00pm) https://events.umich.edu/event/98347 98347-21796523@events.umich.edu Event Begins: Monday, September 12, 2022 12:00pm
Location:
Organized By: Futures in Research, Science, Teaching - FIRST

A science communication program run by the Museum of Natural History and the MCDB department. Create a video based on a past research project/experience to be shared on the Museum's website. Completion of the workshops and final video will earn a science communication certificate.

More details:
https://drive.google.com/file/d/1R0o_bkRGMgPn7L_MVSD_V4b3_j3p8a-Y/view?usp=sharing

Application deadline is Sept. 12th

Please email us with any questions:
SECOND.Contact@umich.edu

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Workshop / Seminar Thu, 08 Sep 2022 17:46:46 -0400 2022-09-12T12:00:00-04:00 2022-09-12T12:00:00-04:00 Futures in Research, Science, Teaching - FIRST Workshop / Seminar SECOND Science Communication
Illuminating the Biochemical Activity Architecture of the Cell (September 12, 2022 4:00pm) https://events.umich.edu/event/95569 95569-21790344@events.umich.edu Event Begins: Monday, September 12, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


Jin Zhang (University of California, San Diego)

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Other Mon, 12 Sep 2022 18:15:26 -0400 2022-09-12T16:00:00-04:00 2022-09-12T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
RNA Innovation Seminar: Zhipeng Lu, USC (September 12, 2022 4:00pm) https://events.umich.edu/event/97465 97465-21794615@events.umich.edu Event Begins: Monday, September 12, 2022 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

HYBRID SEMINAR:
In-person: BSRB, ABC seminar rooms
Zoom: https://umich.zoom.us/webinar/register/WN_ttcO3H-GR3yAJ8JONZegPg#/registration

Abstract: RNA in living cells are in constant motion, form dynamic structures, and interact with many molecules, including other RNAs. Direct determination of RNA structures and interactions in vivo is essential to understanding their functions, but has been challenging in the past. We developed a number of novel chemical and computational tools to capture the 2D and 3D RNA structurome and interactome in cells, providing a comprehensive view of RNA conformations that underlie their roles in gene regulation and human diseases. Applications of these methods revealed new mechanisms in lncRNA functions, RNA modifications and splicing regulation.

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Lecture / Discussion Fri, 26 Aug 2022 09:54:38 -0400 2022-09-12T16:00:00-04:00 2022-09-12T17:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion Zhipeng Lu (鲁志鹏), Ph.D., University of Southern California
Cargo Transport by Dynein/Dynactin- Department of Biological Chemistry Seminar (September 13, 2022 12:00pm) https://events.umich.edu/event/97911 97911-21795310@events.umich.edu Event Begins: Tuesday, September 13, 2022 12:00pm
Location: Off Campus Location
Organized By: Biological Chemistry

Dr. Andrew Carter will present a virtual seminar at 12:00 noon on 9/13/22.

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Workshop / Seminar Thu, 01 Sep 2022 10:36:56 -0400 2022-09-13T12:00:00-04:00 2022-09-13T13:00:00-04:00 Off Campus Location Biological Chemistry Workshop / Seminar
EEB Tuesday Lunch Seminar (Hybrid): Community structure of a natural enemies network: a coffee farm in Mexico (September 13, 2022 12:00pm) https://events.umich.edu/event/97013 97013-21793689@events.umich.edu Event Begins: Tuesday, September 13, 2022 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Our weekly lunch seminar series featuring internal speakers in the field of ecology and evolutionary biology. This seminar will be in-person and livestreaming on Zoom (link this page).

Meeting ID: 98638167446

*Contact eebsemaccess@umich.edu for password*

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Workshop / Seminar Mon, 12 Sep 2022 08:24:00 -0400 2022-09-13T12:00:00-04:00 2022-09-13T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Biological Sciences Building
Futures in Research, Science, and Teaching - General meeting (September 13, 2022 4:00pm) https://events.umich.edu/event/96044 96044-21791846@events.umich.edu Event Begins: Tuesday, September 13, 2022 4:00pm
Location:
Organized By: Futures in Research, Science, Teaching - FIRST

General meetings take place every other Tuesday from September 13 to December 6th. Events include:

September 13th: Pathways in Research (Graduate student/Faculty panel)
September 27th: Mixer (food provided)
October 11th: Poster design and presentation
October 25th: Applying to graduate school - application components and essay writing advice
November 8th: Finding paid summer and post-baccalaureate research opportunities
November 22nd: Faculty talk
December 6th: Mixer

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Meeting Mon, 12 Sep 2022 12:26:57 -0400 2022-09-13T16:00:00-04:00 2022-09-13T17:00:00-04:00 Futures in Research, Science, Teaching - FIRST Meeting Event flyer detailing date, time, and location: September 13th at 4 pm, BSB 1010
Graham DeRuiter (September 13, 2022 4:00pm) https://events.umich.edu/event/90523 90523-21671305@events.umich.edu Event Begins: Tuesday, September 13, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Inorganic
Graham DeRuiter

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Other Wed, 08 Jun 2022 12:15:08 -0400 2022-09-13T16:00:00-04:00 2022-09-13T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
DCMB / CCMB Weekly Seminar (September 14, 2022 4:00pm) https://events.umich.edu/event/97098 97098-21794444@events.umich.edu Event Begins: Wednesday, September 14, 2022 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Talk Title: Deep learning for sequence design with a few data points

Abstract:
Deep learning has begun a renaissance in chemistry and materials. We can devise and fit models to predict molecular properties in a few hours and deploy them in a web browser. We can create novel generative models that were previously PhD theses in an afternoon. In my group, we’re exploring deep learning in peptides. We are focused on two major problems: interpretability and data scarcity. Now that we can make deep learning models to predict any molecular property ad naseum, what can we learn? I will discuss our recent efforts on interpreting deep learning models through symbolic regression and counterfactuals. Data scarcity is a common problem in biochemistry: how can we learn new properties without significant expense of experiments? One method is in judicious choice of experiments, which can be done with active learning. Another approach is self-supervised learning and constraining symmetries, which both try to exploit structure in data. I will cover recent progress in these areas.

Zoom: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Lecture / Discussion Thu, 18 Aug 2022 13:56:14 -0400 2022-09-14T16:00:00-04:00 2022-09-14T17:00:00-04:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
DCM&B Tools and Technology Seminar (September 15, 2022 12:00pm) https://events.umich.edu/event/96847 96847-21793398@events.umich.edu Event Begins: Thursday, September 15, 2022 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

npore is a read realigner which recalculates each read's fine-grained alignment in order to more accurately align ''n-polymers'' such as homopolymers (n=1) and tandem repeats (2 ≤ n ≤ 6). In other words, given an input BAM, it adjusts each read's CIGAR string to more accurately model the most likely sequencing errors and actual variants. Traditional affine gap penalties are context-agnostic, and do not model the higher likelihood of INDELs in low-complexity regions (particularly n-polymers), leading to poor or inconsistent alignments. We find that npore improves pileup concordance across reads and results in slightly better variant calling performance.

Tool Link: https://github.com/TimD1/nPoRe

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

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Presentation Mon, 15 Aug 2022 10:35:55 -0400 2022-09-15T12:00:00-04:00 2022-09-15T13:00:00-04:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
EEB Thursday Seminar (Hybrid): Gene duplications as a source of innovation in freshwater mussels (September 15, 2022 3:00pm) https://events.umich.edu/event/96691 96691-21793089@events.umich.edu Event Begins: Thursday, September 15, 2022 3:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Our weekly seminar series featuring internal and external speakers in the field of ecology and evolutionary biology. This seminar will be in-person and livestreaming on Zoom (link this page).

Abstract
Freshwater Unionid bivalves have recently faced ecological upheaval through pollution, barriers to dispersal, human harvesting, and changes in fish-host prevalence. Currently, over 70% of species are threatened, endangered or extinct. To characterize the genetic response to these recent selective pressures, we collected population genetic data for one successful bivalve species, Megalonaias nervosa. We identify megabase sized regions that are nearly monomorphic across the population, a signal of strong, recent selection reshaping genetic diversity. These signatures of selection encompass a total of 73Mb, greater response to selection than is commonly seen in population genetic models. We observe 102 duplicate genes with high dN/dS on terminal branches among regions with sweeps, suggesting that gene duplication is a causative mechanism of recent adaptation in M. nervosa. Genes in sweeps reflect functional classes known to be important for Unionid survival, including anticoagulation genes important for fish host parasitization, detox genes, mitochondria management, and shell formation. We identify selective sweeps in regions with no known functional impacts, suggesting mechanisms of adaptation that deserve greater attention in future work on species survival. Our work suggests that duplicate genes are an essential source of genetic novelty that has helped this successful species succeed in environments where others have struggled. These results suggest that gene duplications deserve greater attention in non-model population genomics, especially in species that have recently faced sudden environmental challenges.

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Workshop / Seminar Mon, 12 Sep 2022 11:24:02 -0400 2022-09-15T15:00:00-04:00 2022-09-15T16:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Image of the mussel being studied. Photo Credit: Jeff Garner
Engineering Operational Transplant Tolerance via Biomaterials (September 15, 2022 4:30pm) https://events.umich.edu/event/97969 97969-21795406@events.umich.edu Event Begins: Thursday, September 15, 2022 4:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Abstract:
Organ and cell replacement therapies hold great promise for the treatment of multiple conditions, including autoimmune diseases such as type 1 diabetes. Restoration of endogenous insulin production, via cell delivery, has shown to be clinically successful in lowering complications and improving glucose sensing in patients. Yet, a widespread application has been hampered by the need for chronic immunosuppressive drugs to prevent strong inflammatory and immunological responses to the graft. Engineered materials offer a powerful approach for local, selective targeting of immune functionalities without compromising systemic immune function. In this talk, we will highlight engineered synthetic polymeric materials that can promote tissue integration and induce operational tolerance to cell therapies by generating a multifaced regulatory network.

Bio:
Prof Coronel is a Biological scholar and Assistant Professor of Biomedical Engineering at the University of Michigan. Her lab is centered on engineering biomaterials for perturbing and investigating immunological responses. Dr. Coronel received her BS degree in Biomedical Engineering from the University of Miami, and her Ph.D. in Biomedical Engineering from the University of Florida. She also obtained a certificate in Clinical Translational Research from Emory University Public Health School. She finished her postdoctoral fellowship at the Georgia Institute of Technology. Her work has been funded by JDRF, NIH, and the programmable materials initiative at the University of Michigan.

Zoom:
https://umich.zoom.us/j/91375430500

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Workshop / Seminar Thu, 01 Sep 2022 15:04:37 -0400 2022-09-15T16:30:00-04:00 2022-09-15T17:30:00-04:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar BME 500 Seminar
MCDB Seminar> Countering deleterious phase transitions in ALS/FTD (September 16, 2022 12:00pm) https://events.umich.edu/event/98042 98042-21795510@events.umich.edu Event Begins: Friday, September 16, 2022 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Morgan DeSantis

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Workshop / Seminar Mon, 12 Sep 2022 22:03:46 -0400 2022-09-16T12:00:00-04:00 2022-09-16T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow initials MCDB and cartoon of a microscope on a blue background
MCDB Seminar> Visualization of cellular and network rhythmicity in the suprachiasmatic nucleus *in vivo* (September 19, 2022 12:00pm) https://events.umich.edu/event/98043 98043-21795511@events.umich.edu Event Begins: Monday, September 19, 2022 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Sara Aton

*** Note special day: Monday
*** Location: 3150 BSB

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Workshop / Seminar Mon, 12 Sep 2022 22:03:05 -0400 2022-09-19T12:00:00-04:00 2022-09-19T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar cartoon microscope and MCDB initials in yellow on blue background
EEB Tuesday Lunch Seminar - Hybrid: Molecular early burst associated with the diversification of birds at the K–Pg boundary (September 20, 2022 12:00pm) https://events.umich.edu/event/97014 97014-21793691@events.umich.edu Event Begins: Tuesday, September 20, 2022 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Our weekly lunch seminar series featuring internal speakers in the field of ecology and evolutionary biology.

Abstract
A key factor limiting our understanding of early crown bird evolution is a complex history of molecular evolution linked to the Cretaceous–Paleogene (K–Pg) mass extinction and associated changes in life history parameters. Here, we assess molecular heterogeneity across crown bird phylogeny using a new technique, enabling inferred sequence substitution models to transition across the history of a clade. Our approach identifies contrasting patterns among exons, introns, untranslated regions, and mitochondrial genomes that reflect distinct regimes of molecular evolution across the avian phylogeny. Up to fifteen molecular shifts map to rapidly diversifying clades near the end-Cretaceous boundary, demonstrating an "early burst" of genomic disparity. Using simulation and machine learning techniques, we show that shifts in developmental mode or adult body mass best explain transitions in the mode of nucleotide substitution. We further connect these patterns to macroevolutionary shifts in the allometric scaling relationship between basal metabolic rate and body mass. In agreement with theoretical predictions, we show that this scaling relationship became weaker across the end-Cretaceous transition. Thus, our study provides evidence that the Chicxulub bolide impact triggered integrated patterns of evolution across avian genomes, physiology, and life history that structured the evolutionary potential of modern birds.

This seminar will be in-person and livestreaming on Zoom (link this page). Contact eebsemaccess@umich.edu for Zoom password at least 2 hours prior to event.

Image: Steve Day CC BY-SA 2.0

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Workshop / Seminar Mon, 19 Sep 2022 09:32:51 -0400 2022-09-20T12:00:00-04:00 2022-09-20T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Detail of the painted ceiling in Waltham Abbey parish church, depicting the two-faced god Janus (photo by Steve Day CC BY-SA 2.0)
Next-Generation Protein Stability Measurements Performed in the Absence of Bulk Solvent- Department of Biological Chemistry Seminar (September 20, 2022 12:00pm) https://events.umich.edu/event/97912 97912-21795311@events.umich.edu Event Begins: Tuesday, September 20, 2022 12:00pm
Location: Medical Science Unit I
Organized By: Biological Chemistry

Dr. Ruotolo will give a seminar on 9/20/22 at 12:00pm

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Workshop / Seminar Thu, 01 Sep 2022 10:41:52 -0400 2022-09-20T12:00:00-04:00 2022-09-20T13:00:00-04:00 Medical Science Unit I Biological Chemistry Workshop / Seminar
Catalyst RE-Design: Dynamic, Reactive, and Selective Systems for Oxygenated Polymer Synthesis (September 20, 2022 4:00pm) https://events.umich.edu/event/95777 95777-21790892@events.umich.edu Event Begins: Tuesday, September 20, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Polymer waste has quickly become one of our society\'s largest looming environmental concerns, where an estimated 4.9 GTons of polymer waste currently exist in the environment. Central to addressing this challenge is the generation of polymers with robust materials properties that embed or encode end-of-use. Oxygenated (co)polymers such as polyhydroxyalkanoates are naturally occurring and fully bioresorbable polymers with promising materials properties, yet their efficient and cost-effective stereospecific synthesis remains challenging. In this talk, I will share some of our group\'s recent advances in catalyst development for the synthesis of oxygenated (co)polymers. Specifically, we\'ll discuss how new catalyst design strategies which fully leverage the high metal-ligand lability of the rare-earth elements can lead to systems which are highly dynamic, reactive, and selective.

Jerome Robinson (Brown)

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Other Tue, 20 Sep 2022 18:15:24 -0400 2022-09-20T16:00:00-04:00 2022-09-20T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
CPOD Seminar Talk: Brian Capell, MD, PhD, (UPenn) Chromatin at the nexus of epithelial development, differentiation, and cancer (September 20, 2022 4:00pm) https://events.umich.edu/event/98510 98510-21796732@events.umich.edu Event Begins: Tuesday, September 20, 2022 4:00pm
Location: Off Campus Location
Organized By: Center for Cell Plasticity and Organ Design

Center for Cell Plasticity and Organ Design with UM-Skin Biology and Disease Resource based Center presents:

Brian Capell, MD, PhD
University of Pennsylvania
Chromatin at the nexus of epithelial development, differentiation, and cancer
In-Person: BSRB ABC Seminar Rooms
Zoom Meeting Option ID: 932 944 30678

Faculty Host: Rajesh Rao, MD
Leonard G. Miller Professor of Ophthalmology and Visual Sciences

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Lecture / Discussion Mon, 12 Sep 2022 11:52:11 -0400 2022-09-20T16:00:00-04:00 2022-09-20T17:00:00-04:00 Off Campus Location Center for Cell Plasticity and Organ Design Lecture / Discussion Capell
2nd Annual U-M Drug Discovery Symposium (September 21, 2022 9:00am) https://events.umich.edu/event/96651 96651-21793014@events.umich.edu Event Begins: Wednesday, September 21, 2022 9:00am
Location: Rackham Graduate School (Horace H.)
Organized By: Michigan Drug Discovery

Date: Wednesday, September 21, 2022
Time: 9:00am-4:00pm EST
Location: Rackham Building (915 E Washington)
~~This event is only open to current U-M students/trainees, staff, and faculty members~~

The second Annual U-M Drug Discovery Symposium aims to highlight success stories from the drug discovery community at Michigan, share best practices, and provide opportunities for networking.

Keynote Speaker:
Nicholas Meanwell, Ph.D.; Bristol Myers Squibb

Featured Speakers:
Mukesh Nyati, Ph.D.
Zaneta Nikolovska-Coleska, Ph.D.
James Shayman, M.D.
Peter Scott, Ph.D.



Questions/Comments please contact us at: drugdiscovery@umich.edu

Visit our event website for full details and schedule:
https://www.lsi.umich.edu/events/2022-09/annual-u-m-drug-discovery-symposium

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Conference / Symposium Mon, 19 Sep 2022 12:43:33 -0400 2022-09-21T09:00:00-04:00 2022-09-21T16:00:00-04:00 Rackham Graduate School (Horace H.) Michigan Drug Discovery Conference / Symposium Michigan Drug Discovery
DCMB Weekly Seminar (September 21, 2022 4:00pm) https://events.umich.edu/event/98815 98815-21797218@events.umich.edu Event Begins: Wednesday, September 21, 2022 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract:
The intersect between the life sciences (cells, tissues, organs) and engineered materials (polymers, biomacromolecules, semiconductors) is crucial for a wide range of medical and biotechnological applications. Hence, the precise control of biotic/abiotic interfaces has been one of the main obstacles of past decades. The Lahann Lab designs polymers for a range of different medical applications. In particular, we have developed a class of protein nanoparticles for targeting of glioblastoma. In addition, I will summarize our efforts related to sheet-like 3D organoid systems and will address recent advances with morphologically designed interfaces.

Research Interests:
Designer surfaces, advanced polymers, biomimetic materials, microfluidic devices, engineered microenvironments, nano-scale self-assembly.

Joerg Lahann’s research is broadly related to surface engineering with strong ties to biomedical engineering and nanotechnology. His research on reversibly switching surfaces was featured in an article in Science (J. Lahann, et al., A Reversibly Switching Surface, January 17, 2003, 299, 371-374.) These “smart surfaces” can reversibly switch properties in response to an external stimulus. To demonstrate these findings, a surface design was developed that can be changed from water-attracting to water-repelling with the application of a weak electric field. Designed as a switch, single-layered molecular-level machines are aligned on a surface using self-assembly and then are flipped between defined microscopic states. This type of surface design may offer a new paradigm for interfacial engineering as it amplifies reversible conformational transitions at a molecular level to macroscopic changes in surface properties without altering the chemical identity of the surface.

Joerg has also developed a novel class of polymers with potential for biomimetic and spatially directed surface engineering. This “reactive coating” technology uses chemical vapor deposition (CVD) polymerization to deposit a wide range of chemical signatures on various substrate materials. Its simplicity in providing chemically reactive groups and its applicability to three-dimensional geometries (e.g., for microfluidics) enables the exact tailoring of surface properties and the preparation of biologically relevant microenvironments. Reactive coatings are compatible with soft lithographic processes, allowing for patterning of proteins, DNA, cytokines, and mammalian cells.

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Lecture / Discussion Thu, 15 Sep 2022 11:36:52 -0400 2022-09-21T16:00:00-04:00 2022-09-21T17:00:00-04:00 Palmer Commons DCMB Seminar Series Lecture / Discussion (Protein pattern deposited on a polymer surface, artistic rendering, credit: Bahar Dadfar)
DCM&B Tools and Technology Seminar (September 22, 2022 12:00pm) https://events.umich.edu/event/96848 96848-21793400@events.umich.edu Event Begins: Thursday, September 22, 2022 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

This presentation will be given remotely, with the livestream available for group viewing in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

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Presentation Mon, 15 Aug 2022 10:42:50 -0400 2022-09-22T12:00:00-04:00 2022-09-22T13:00:00-04:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
LHS Collaboratory (September 22, 2022 12:00pm) https://events.umich.edu/event/96027 96027-21791723@events.umich.edu Event Begins: Thursday, September 22, 2022 12:00pm
Location: Palmer Commons
Organized By: Department of Learning Health Sciences

LHS Collaboratory Kickoff Poster Session Showcasing LHS Work at the University of Michigan

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Lecture / Discussion Tue, 12 Jul 2022 10:55:57 -0400 2022-09-22T12:00:00-04:00 2022-09-22T14:00:00-04:00 Palmer Commons Department of Learning Health Sciences Lecture / Discussion LHS Collaboratory logo
OHS Seminar Series Schedule (September 22, 2022 12:00pm) https://events.umich.edu/event/98131 98131-21795615@events.umich.edu Event Begins: Thursday, September 22, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

OHS Seminar Series Schedule Fall 2022 - Stay tuned for more updates!

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Presentation Tue, 06 Sep 2022 13:16:28 -0400 2022-09-22T12:00:00-04:00 2022-09-22T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Presentation OHS Seminar Series Schedule Fall 2022
Postdoc Appreciation Week – Special Presentations (September 22, 2022 12:00pm) https://events.umich.edu/event/98318 98318-21796492@events.umich.edu Event Begins: Thursday, September 22, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

Felicia Miranda, DDS, MS, PhD
Postdoctoral Fellow
Department of Orthodontics
University of Michigan School of Dentistry
Mentor: Lucia Cevidanes

Amanda Rodriguez, DDS, MS
Research Fellow & PiMA Program Assistant Director
Department of Periodontics and Oral Medicine
University of Michigan School of Dentistry
Mentors: Drs. Hsun-Liang Chan, DDS, MS and
Oliver Kripfgans, PhD

Hiroki Ueharu, Ph.D.
Department of Biologic & Materials Sciences and Prosthodontics, University of Michigan School of Dentistry
Mentor: Dr. Yuji Mishina

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Presentation Thu, 08 Sep 2022 12:20:48 -0400 2022-09-22T12:00:00-04:00 2022-09-22T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Presentation Postdoc Appreciation Week – Special Presentations
EEB Thursday Seminar: CANCELLED (September 22, 2022 3:00pm) https://events.umich.edu/event/96692 96692-21793090@events.umich.edu Event Begins: Thursday, September 22, 2022 3:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

See you next week!

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Workshop / Seminar Thu, 15 Sep 2022 15:27:13 -0400 2022-09-22T15:00:00-04:00 2022-09-22T16:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Biological Sciences Building
Metabolic Reprogramming of Donor Hearts to Improve Function (September 22, 2022 4:30pm) https://events.umich.edu/event/98895 98895-21797323@events.umich.edu Event Begins: Thursday, September 22, 2022 4:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Abstract:
Harmful metabolic processes are well underway during cold preservation of donor hearts. We discovered a method to increase the expression of beneficial enzymes which augment the production of anti-inflammatory metabolites. This leads to lowered oxidative stress, reduced myocardial injury and translates into better cardiac function following transplantation. Future strategies to reduce primary graft dysfunction could involve precise modulation of these cardiac metabolic pathways.

Bio:
Paul Tang is an Assistant Professor of Cardiac Surgery at the University of Michigan-Ann Arbor. His cardiothoracic surgery training was completed at Duke University Medical Center where he also received advanced training in heart transplantation, ventricular assist devices and aortic surgery. He has given talks and published widely on the natural history and surgical outcomes of these diseases. At Yale University, Dr. Tang completed a PhD focused on cardiovascular immunology. Dr. Tang's clinical practice includes surgical treatment of heart failure (i.e. heart transplantation, ventricular assist devices), valvular repair or replacement, and aortic aneurysm surgery. He is an investigator in various national clinical trials for heart failure management, and is a member of professional societies such as The International Society for Heart and Lung Transplantation, Southern Thoracic Surgical Association, American Heart Association, and the Society of Thoracic Surgeons.​​​​​​​

Zoom:
https://umich.zoom.us/j/91375430500

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Workshop / Seminar Fri, 16 Sep 2022 16:19:36 -0400 2022-09-22T16:30:00-04:00 2022-09-22T17:30:00-04:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar BME 500 Seminar
2022 Functional MRI Symposium (September 23, 2022 9:00am) https://events.umich.edu/event/98230 98230-21795746@events.umich.edu Event Begins: Friday, September 23, 2022 9:00am
Location: East Hall
Organized By: Functional MRI Lab

The Functional MRI Laboratory is dedicated to supporting research on the structures and functions of the brain that underlie cognitive and affective processes in normal and clinical populations, as well as research on non-invasive methods for functional MRI and associated research tools, including brain stimulation.

The day will be devoted to talks that cover a range of issues having to do with data analysis, and, of course, connecting these issues to relevant topics in psychology and neuroscience.

Please go to the fMRI website (on the right) to register.

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Conference / Symposium Thu, 15 Sep 2022 18:06:17 -0400 2022-09-23T09:00:00-04:00 2022-09-23T16:00:00-04:00 East Hall Functional MRI Lab Conference / Symposium Fall 2022
Engineering Reproduction: From Bench to Bedside to Babies (September 23, 2022 12:00pm) https://events.umich.edu/event/97221 97221-21794154@events.umich.edu Event Begins: Friday, September 23, 2022 12:00pm
Location:
Organized By: LSA Biophysics

N/A

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Workshop / Seminar Thu, 22 Sep 2022 16:30:13 -0400 2022-09-23T12:00:00-04:00 2022-09-23T13:30:00-04:00 LSA Biophysics Workshop / Seminar
MCDB Seminar> GTPase regulation of the Golgi apparatus (September 23, 2022 12:00pm) https://events.umich.edu/event/98604 98604-21796961@events.umich.edu Event Begins: Friday, September 23, 2022 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Ming Li

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Workshop / Seminar Thu, 15 Sep 2022 09:28:24 -0400 2022-09-23T12:00:00-04:00 2022-09-23T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow cartoon microscope on blue background
RNA Innovation Seminar: David Shechner, University of Washington (September 26, 2022 4:00pm) https://events.umich.edu/event/97617 97617-21794810@events.umich.edu Event Begins: Monday, September 26, 2022 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

David Shechner Ph.D.
Assistant Professor of Pharmacology
University of Washington

Keywords: RNA, proximity-biotinylation, subcellular architecture, nuclear architecture, spatial biology, biomolecular condensates, interactomics, nucleolus, Xist.

Abstract: In the context of the living cell, very little RNA is naked. RNA molecules form complex, dynamic networks of molecular interactions that underlie a host of biochemical functions, and which are central to organizing subcellular compartmentalization. In humans, for example, RNAs are key determinants of chromatin folding, and they nucleate and scaffold a host of biomolecular condensates that collectively control cellular metabolic, epigenetic, and stress-signaling pathways. But, characterizing these structures—identifying the biomolecules within an RNA's subcellular microenvironment—remains technically cumbersome.

To address this challenge, I introduce oligonucleotide-mediated proximity-interactome mapping (O-MAP), a straightforward and flexible method for identifying the proteins, RNAs, and genomic loci near a target RNA, within its native cellular context. O-MAP uses programmable oligonucleotide probes to deliver proximity-biotinylating enzymes to a target RNA. These enzymes then pervasively label all nearby (~20 nm) molecules, enabling their enrichment by streptavidin pulldown. O-MAP induces exceptionally precise RNA-targeted biotinylation, and its modular design enables straightforward validation of probe pools and real-space optimization of the biotinylation radius, thus overcoming key technical challenges for the field. Moreover, O-MAP can be readily ported across different target RNAs and specimen types, including patient-derived organoids and tissue samples. And, O-MAP achieves this without complex cell-line engineering, using only off-the-shelf parts and standard manipulations.

Using a small cohort of model RNAs, we have developed a robust O-MAP toolkit for proteomic (O-MAP-MS), transcriptomic (O-MAP-Seq) and genome interaction (O-MAP-ChIP) discovery. O-MAP of the 47S-pre-rRNA—the long noncoding RNA that scaffolds the nucleolus—enabled a comprehensive "multi-omic" analysis of this subnuclear structure, and revealed hundreds of novel nucleolar protein-, RNA-, and chromatin interactions. O-MAP of XIST—the master regulator of X-chromosome inactivation—revealed novel RNAs that may play a role in this process, and unanticipated interactions between XIST and other chromatin-regulatory RNAs. Finally, targeting O-MAP to introns within a key cardiac developmental gene enabled unprecedented molecular dissection of a subnuclear compartment that would be impossible to purify biochemically.

Given these results, we believe that O-MAP will be a powerful tool for elucidating the mechanisms by which RNA molecules drive subcellular compartmentalization in time and space, with particular impact on our understanding of nuclear architecture. Moreover, with O-MAP's precision, flexibility, and ease, we anticipate its broad use in studying countless other RNA phenomena throughout biology, and as a clinical diagnostic- and discovery tool.


HYBRID SEMINAR:
In-person: BSRB, ABC seminar rooms
Livestream: https://myumi.ch/NmGqG

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Lecture / Discussion Tue, 06 Sep 2022 10:16:25 -0400 2022-09-26T16:00:00-04:00 2022-09-26T17:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion David Shechner, University of Washington
EEB Tuesday Lunch Seminar - Hybrid: Daphnia - the master of trade-offs (September 27, 2022 12:00pm) https://events.umich.edu/event/97015 97015-21793692@events.umich.edu Event Begins: Tuesday, September 27, 2022 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Our weekly lunch seminar series featuring internal speakers in the field of ecology and evolutionary biology.

This seminar will be in-person and livestreaming on Zoom (link this page). Contact eebsemaccess@umich.edu for password at least two hours prior to the event.

Abstract
Every organism is confronted with endless amount of challenges during its lifetime. Some of the challenges can be avoided, for others the organism is prepared for (due to evolutionary adaptation), but most of those challenges turn out to be costly to confront. In such cases the focal organism frequently faces a trade-off – necessity to pay for improvement in one trait with deterioration in another trait.

Daphnia is almost constantly found between a rock and a hard place, and yet it is ubiquitous and dominates most of the lakes and ponds. It’s resilience to variety of environmental challenges stems from some impressive adaptations, enormous phenotypic plasticity, and mastery in performing beneficial trade-offs. During the seminar I will present some of the fascinating ways in which Daphnia avoids or mitigates threats like changing climate, parasitism or predation.

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Workshop / Seminar Mon, 26 Sep 2022 12:41:41 -0400 2022-09-27T12:00:00-04:00 2022-09-27T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Drawing of a large fish behind a worried looking Daphnia behind some smaller organisms. Illustration: Marcin Dziuba
PBBs in Michigan: Empowering an Exposed Community (September 27, 2022 12:00pm) https://events.umich.edu/event/98897 98897-21797325@events.umich.edu Event Begins: Tuesday, September 27, 2022 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Featuring Bonnie Havlicek, RN (Co-Chair PBB Advisory Board) and Michele Marcus, PhD, MPH (Professor, Departments of Epidemiology, Environmental Health & Pediatrics, Schools of Public Health and Medicine, Emory University). Moderated by Amy Schulz, PhD (M-LEEaD CEC Core Leader, UM SPH).

Registration required for Zoom webinar https://bit.ly/3Le7hby

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Workshop / Seminar Fri, 16 Sep 2022 16:26:51 -0400 2022-09-27T12:00:00-04:00 2022-09-27T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Workshop / Seminar Residents & Researchers Tuesday Talks
Structural Basis for HCMV Receptor Recognition and Antibody Neutralization- Department of Biological Chemistry Seminar (September 27, 2022 12:00pm) https://events.umich.edu/event/97914 97914-21795313@events.umich.edu Event Begins: Tuesday, September 27, 2022 12:00pm
Location: Medical Science Unit I
Organized By: Biological Chemistry

Dr. Claudio Ciferri will give a seminar at 12:00pm on 9/27/2022

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Workshop / Seminar Thu, 01 Sep 2022 10:46:36 -0400 2022-09-27T12:00:00-04:00 2022-09-27T13:00:00-04:00 Medical Science Unit I Biological Chemistry Workshop / Seminar
Futures in Research, Science, and Teaching - General meeting (September 27, 2022 4:00pm) https://events.umich.edu/event/96044 96044-21791847@events.umich.edu Event Begins: Tuesday, September 27, 2022 4:00pm
Location:
Organized By: Futures in Research, Science, Teaching - FIRST

General meetings take place every other Tuesday from September 13 to December 6th. Events include:

September 13th: Pathways in Research (Graduate student/Faculty panel)
September 27th: Mixer (food provided)
October 11th: Poster design and presentation
October 25th: Applying to graduate school - application components and essay writing advice
November 8th: Finding paid summer and post-baccalaureate research opportunities
November 22nd: Faculty talk
December 6th: Mixer

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Meeting Mon, 12 Sep 2022 12:26:57 -0400 2022-09-27T16:00:00-04:00 2022-09-27T17:00:00-04:00 Futures in Research, Science, Teaching - FIRST Meeting Event flyer detailing date, time, and location: September 13th at 4 pm, BSB 1010
Investigating Sociocultural and Environmental Factors Related to Students’ Chemistry Identity Development (September 27, 2022 4:00pm) https://events.umich.edu/event/94228 94228-21726176@events.umich.edu Event Begins: Tuesday, September 27, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

ChemEd
Justin Carmel (Florida International University)

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Other Tue, 27 Sep 2022 18:15:25 -0400 2022-09-27T16:00:00-04:00 2022-09-27T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
OHS Seminar Series Schedule (September 29, 2022 12:00pm) https://events.umich.edu/event/98131 98131-21795616@events.umich.edu Event Begins: Thursday, September 29, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

OHS Seminar Series Schedule Fall 2022 - Stay tuned for more updates!

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Presentation Tue, 06 Sep 2022 13:16:28 -0400 2022-09-29T12:00:00-04:00 2022-09-29T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Presentation OHS Seminar Series Schedule Fall 2022
10th Anniversary Symposium & Celebration - Department of Computational Medicine & Bioinformatics (September 29, 2022 1:15pm) https://events.umich.edu/event/98793 98793-21797190@events.umich.edu Event Begins: Thursday, September 29, 2022 1:15pm
Location: Taubman Biomedical Science Research Building
Organized By: Omenn Lecture

On September 29, 2022, the University of Michigan Department of Computational Medicine and Bioinformatics (DCMB) will celebrate its 10th anniversary with a symposium and in-person gathering.

The event will be introduced by James Woolliscroft, M.D., Lyle C. Roll Professor of Medicine, and former dean of the Medical School. Department faculty members will present about their research, and two distinguished alumni –Erin Shellman, Ph.D., Head of Data at Gingko Bioworks, and Dan Rhodes, Ph.D., co-founder and CEO at Strata Oncology – will talk about their respective careers.

At 4:00 p.m., Holden Thorp, Ph.D., editor-in-chief, Science Family of Journals will give the 8th Annual G. Omenn Lecture: "Data Science and Medicine in the Age of Open Data, Open Code, and Open Access: From Protein Structure Prediction to COVID Origins"

A poster session will close the afternoon. For more information and registration, visit our website.

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Lecture / Discussion Wed, 14 Sep 2022 16:17:20 -0400 2022-09-29T13:15:00-04:00 2022-09-29T18:30:00-04:00 Taubman Biomedical Science Research Building Omenn Lecture Lecture / Discussion DCMB 10th Anniversary Symposium & Celebration
EEB Thursday Seminar - Hybrid: Genetic conflict and the evolution of genome integrity (September 29, 2022 3:00pm) https://events.umich.edu/event/96693 96693-21793091@events.umich.edu Event Begins: Thursday, September 29, 2022 3:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Our weekly seminar series featuring internal and external speakers in the field of ecology and evolutionary biology. This seminar will be in-person and livestreaming on Zoom (link this page).

Abstract:
A single genome appears to be a cohesive community of distinct genes with common incentives. Across development, genes collaborate to build a robust and fertile individual. Across evolution, genes accumulate adaptive DNA sequence changes that build an even more robust, and even more fertile, individual. The more robust and fertile the individual, the more copies of all these genes in the next generation. In this way, our genome’s distinct genes contribute to a communal good. However, much of our DNA actually serves no beneficial function. Most of this DNA has minimal effect on our health and fertility; consequently, natural selection fails to efficiently purge it from our genome. Some of this DNA harms us. This so-called “selfish DNA” acts akin to viruses, hijacking our cell’s machinery to make more copies of itself. While most viruses achieve evolutionary success upon transmission from one individual to another, these selfish elements achieve evolutionary success by increasing their own genomic copy number from one generation to another. When selfish elements win, the rest of the genome loses. Compromised Darwinian fitness puts evolutionary pressure on our genome to police these elements. Selfish DNA fights back with counter-adaptations, escalating a “molecular arms race.” In my seminar, I will describe my lab’s efforts to define the identity, molecular mechanisms, and biological consequences of such genetic conflicts between genomic hijackers and genomic guardians. To gain these insights, we generate interspecies swaps of adaptively evolving proteins that package the rapidly evolving repetitive DNA around
the telomeres and centromeres of Drosophila melanogaster. Using cell biology, next generation sequencing, and classical genetics, we probe how intra-genomic conflict between genes and DNA repeats shapes the evolution of genome integrity.

Contact eebsemaccess@umich.edu for Zoom password at least 2 hours prior to event.

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Workshop / Seminar Thu, 22 Sep 2022 15:19:06 -0400 2022-09-29T15:00:00-04:00 2022-09-29T16:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Telomeres being studied by the lab. Photo Credit: Mia Levine
Concussion Center Speaker Series (September 29, 2022 4:00pm) https://events.umich.edu/event/98787 98787-21797182@events.umich.edu Event Begins: Thursday, September 29, 2022 4:00pm
Location: School of Kinesiology Building
Organized By: Michigan Concussion Center

Join us on Thursday, 9/29, as the University of Michigan Concussion Center presents Dr. Douglas Smith, endowed professor of teaching and research in Neurosurgery and director of the Center for Brain Injury and Repair, Department of Neurosurgery at the University of Pennsylvania, for the presentation "Tackling the Mechanisms and Aftermath of Concussion."

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Presentation Wed, 14 Sep 2022 13:49:17 -0400 2022-09-29T16:00:00-04:00 2022-09-29T17:00:00-04:00 School of Kinesiology Building Michigan Concussion Center Presentation Dr. Douglas Smith Speaker Series
Incorporation and molecular level consequences of mRNA modifications (September 29, 2022 4:00pm) https://events.umich.edu/event/96495 96495-21792591@events.umich.edu Event Begins: Thursday, September 29, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Cells face the daunting task of maintaining the right number of proteins, at the right time, under rapidly changing conditions. One way that nature accomplishes this is by chemically modifying DNA, RNA and protein molecules to control their structure, function, stability and localization. A single cell possesses thousands of enzymatically modified RNA sites. These modifications have the potential to directly impact protein production, and disruptions in the RNA modification landscape are associated with an array of diseases including cancers, neurological diseases, and diabetes. Nonetheless, it remains to be discovered how individual sites of modification influence the function of a given RNA. We are working to ascertain how modifications to the molecular blueprints for protein synthesis, messenger RNAs (mRNAs), influence protein production. Our studies have led to the discovery of new mRNA modifications, reframed the current model for RNA modifying enzyme target selection, and identified modifications that change the speed and accuracy of protein synthesis. These findings lay the foundation for establishing complex rules governing the molecular level consequences of mRNA modifications.
Kristin Koutmou

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Other Thu, 29 Sep 2022 18:15:25 -0400 2022-09-29T16:00:00-04:00 2022-09-29T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
BIBC Technologies in Brain Cancer Symposium (September 30, 2022 8:00am) https://events.umich.edu/event/95345 95345-21789202@events.umich.edu Event Begins: Friday, September 30, 2022 8:00am
Location: Taubman Biomedical Science Research Building
Organized By: BioInnovations in Brain Cancer

The BioInnovations in Brain Cancer’s inaugural symposium is bringing together scientists to bridge the gap between brain cancer biology research and novel technological developments in order to advance the diagnosis and treatment of glioma to improve the lives of patients.

The symposium will include talks from key opinion leaders from the basic sciences to translation covering a wide range of topics in pharmaceutical sciences, engineering, and biomedical innovations. We will also be hosting a poster session, exhibitions and networking events in order to share knowledge and build a community of diverse expertise

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Conference / Symposium Tue, 31 May 2022 13:37:44 -0400 2022-09-30T08:00:00-04:00 2022-09-30T19:00:00-04:00 Taubman Biomedical Science Research Building BioInnovations in Brain Cancer Conference / Symposium BIBC Symposium Flyer
Environmental and Climate Justice Conference (September 30, 2022 8:45am) https://events.umich.edu/event/98083 98083-21795572@events.umich.edu Event Begins: Friday, September 30, 2022 8:45am
Location: Jeffries Hall
Organized By: Michigan Law Environmental and Energy Law Program

During previous Environmental Law and Policy Program (ELPP) conferences, we have featured panel discussions on climate change as part of broader conversations about environmental law and policy. With climate change accelerating and the window for climate change mitigation and adaptation narrowing, this year we will devote the program to how the legal system can promote meaningful action on climate change and environmental sustainability efforts.

See full details and the conference schedule at:
https://michigan.law.umich.edu/environmental-and-climate-justice-conference

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Conference / Symposium Tue, 06 Sep 2022 08:53:56 -0400 2022-09-30T08:45:00-04:00 2022-09-30T16:30:00-04:00 Jeffries Hall Michigan Law Environmental and Energy Law Program Conference / Symposium
Optogenetic Feedback Control of Gene Expression and Antibiotic Resistance in Single Cells (September 30, 2022 12:00pm) https://events.umich.edu/event/97236 97236-21794168@events.umich.edu Event Begins: Friday, September 30, 2022 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Cell-to-cell heterogeneity in gene expression can elevate antibiotic resistance in one microbe while other cells remain susceptible. These transient forms of drug resistance are often stochastic and dynamic, leading to single-cell level differences in resistance that change with time. To date, methods for quantifying these effects have relied on careful observations of native expression patterns. In this talk, I will discuss a novel approach for controlling gene expression dynamics in single cells that can be used to precisely drive expression in thousands of cells in parallel. In support of this, I will discuss our recent advances in automated image processing of time-lapse microscopy data using deep learning models (DeLTA). Once trained, the DeLTA algorithm requires minimal input from the user and can rapidly segment, track, and reconstruct lineages for bacteria growing in microfluidic chips and on two dimensional surfaces. I will also discuss optogenetic control methods that allow us to use light-based feedback to regulate gene expression in real time. Using a combination of deep learning-based models and rapid image analysis, we can simultaneously control gene expression in thousands of cells in parallel. Together, these approaches offer powerful methods that can be used to quantify and control cell-to-cell heterogeneity in antibiotic resistance, providing a detailed view into strategies bacteria can use to evade drug treatment.

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Workshop / Seminar Mon, 26 Sep 2022 09:56:19 -0400 2022-09-30T12:00:00-04:00 2022-09-30T13:30:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
BIBC Technologies in Brain Cancer Symposium (October 1, 2022 8:00am) https://events.umich.edu/event/95345 95345-21789203@events.umich.edu Event Begins: Saturday, October 1, 2022 8:00am
Location: Taubman Biomedical Science Research Building
Organized By: BioInnovations in Brain Cancer

The BioInnovations in Brain Cancer’s inaugural symposium is bringing together scientists to bridge the gap between brain cancer biology research and novel technological developments in order to advance the diagnosis and treatment of glioma to improve the lives of patients.

The symposium will include talks from key opinion leaders from the basic sciences to translation covering a wide range of topics in pharmaceutical sciences, engineering, and biomedical innovations. We will also be hosting a poster session, exhibitions and networking events in order to share knowledge and build a community of diverse expertise

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Conference / Symposium Tue, 31 May 2022 13:37:44 -0400 2022-10-01T08:00:00-04:00 2022-10-01T19:00:00-04:00 Taubman Biomedical Science Research Building BioInnovations in Brain Cancer Conference / Symposium BIBC Symposium Flyer
When pull turns to shove: modeling how tribalism and environmental bias form ideological distributions in large populations (October 4, 2022 11:30am) https://events.umich.edu/event/99424 99424-21798309@events.umich.edu Event Begins: Tuesday, October 4, 2022 11:30am
Location: Weiser Hall
Organized By: The Center for the Study of Complex Systems

HYRBID SEMINAR:
https://umich.zoom.us/j/96616169868
Password: CSCS (all caps)
Weiser Hall Room 747

11:30 AM

Abstract: Modeling the dynamics of political ideology can help us understand societal issues like polarization, which affect the evolution of many systems of power. This talk will go over our modeling framework, which utilizes a network-free system of determining political influence and a local-attraction, distal-repulsion dynamic for reaction to perceived content. Our approach allows for the incorporation of intergroup bias such that messages from trusted in-group sources enjoy greater leeway than out-group ones. We are able to extrapolate these nonlinear microscopic dynamics to macroscopic population distributions by tying them to inputs from systematically biased, probabilistic environments. The framework we put forward can reproduce both real-world political distributions and experimentally observed dynamics, and---importantly---is amenable to further refinement as more data becomes available.

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Workshop / Seminar Thu, 29 Sep 2022 09:36:57 -0400 2022-10-04T11:30:00-04:00 2022-10-04T13:00:00-04:00 Weiser Hall The Center for the Study of Complex Systems Workshop / Seminar Photo of David Sabin Miller
Early Life ROS as Modulators of Aging and Age-Associated Diseases- Department of Biological Chemistry Seminar Series (October 4, 2022 12:00pm) https://events.umich.edu/event/98980 98980-21797422@events.umich.edu Event Begins: Tuesday, October 4, 2022 12:00pm
Location: Off Campus Location
Organized By: Biological Chemistry

Dr. Ursula Jakob will present the Department of Biological Chemistry seminar on Tuesday October 4th, 2022 at 12:00pm via zoom.

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Workshop / Seminar Mon, 19 Sep 2022 09:11:09 -0400 2022-10-04T12:00:00-04:00 2022-10-04T13:00:00-04:00 Off Campus Location Biological Chemistry Workshop / Seminar
Early Life ROS as Modulators of Aging and Age-Associated Diseases-Department of Biological Chemistry Seminar Series (October 4, 2022 12:00pm) https://events.umich.edu/event/99067 99067-21797520@events.umich.edu Event Begins: Tuesday, October 4, 2022 12:00pm
Location: Off Campus Location
Organized By: Biological Chemistry

Dr. Jakob will present a seminar for the Department of Biological Chemistry at 12 noon on Tuesday October 4th, 2022.

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Workshop / Seminar Tue, 20 Sep 2022 08:17:40 -0400 2022-10-04T12:00:00-04:00 2022-10-04T13:00:00-04:00 Off Campus Location Biological Chemistry Workshop / Seminar
EEB Tuesday Lunch Seminar - Hybrid: Character evolution and homoplasy in the New World milkvetches (Astragalus, Fabaceae) (October 4, 2022 12:00pm) https://events.umich.edu/event/97016 97016-21793693@events.umich.edu Event Begins: Tuesday, October 4, 2022 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Our weekly lunch seminar series featuring internal speakers in the field of ecology and evolutionary biology.

Abstract
Astragalus L. (Fabaceae) is possibly the most species-rich genus of seed plants with more than 3,000 recognized species. Almost 500 of those species (commonly called milkvetches or locoweeds) in the Americas are part of a clade called Neo-Astragalus and are estimated to have shared a common ancestor as recently as 4.5 million years ago. However, as largely temperate, perennial herbaceous plants, these species are rather ecologically similar compared to classic examples of plant adaptive radiations. Using phylogenies estimated from whole chloroplast genomes and nuclear ribosomal DNA, I will explore cryptic (or difficult to observe) differentiation in Neo-Astragalus by examining character evolution and homoplasy in morphological traits as well as the accumulation of selenium. About two dozen Neo-Astragalus species are selenium hyperaccumulators that are not only restricted to soils already rich in the element but also accumulate it to the point they are highly toxic to most herbivores. Convergent evolution in this trait could be indicative of other kinds of cryptic but ecologically important disparity that may have developed during the evolution of Neo-Astragalus in the Americas and in Astragalus as a whole.

This seminar will be in-person and livestreaming on Zoom (link this page).

Contact eebsemaccess@umich.edu for password at least two hours prior to the event.

Image credit: Joseph Charboneau

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Workshop / Seminar Thu, 29 Sep 2022 11:52:32 -0400 2022-10-04T12:00:00-04:00 2022-10-04T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Astragalus sophoroides (Painted Desert milkvetch) in the Navajo Nation in Arizona. Image credit: Joseph Charboneau
The Interplay of Maternal Diet with Environmental Exposures in Pregnancy (October 4, 2022 12:00pm) https://events.umich.edu/event/99286 99286-21797811@events.umich.edu Event Begins: Tuesday, October 4, 2022 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Registration required https://bit.ly/3Lzeh39

Rita Strakovsky, PhD, RD is an Assistant Professor of Maternal Nutrition and Toxicology in the Department of Food Science and Human Nutrition at Michigan State University.

Dr. Strakovsky's research focuses on various modifiable lifestyle and environmental factors that can be targeted to protect maternal and child health.

She has worked extensively in rodent pregnancy models to study the effects of maternal diet or exposure to environmental endocrine disrupting chemicals (EDCs) on the epigenetic regulation of energy metabolism in offspring. Driven by findings from these studies, my current research in human populations uses molecular epidemiology and biostatistics techniques to address several questions related to the health of mom and her developing fetus during pregnancy:
* Does exposure to endocrine disrupting chemicals in pregnancy impact maternal hormone levels and how does that impact fetal development via dysregulation of fetal fatty acid supply? (supported by K99/R00 award from NIEHS).
* Does exposure to phthalates in pregnancy impact maternal long-term cardiometabolic health, and does hormonal disruption mediate this relationship? (supported by R01 award from NIEHS).
* Do mixtures of dietary micronutrients impact length of gestation, and does diet quality or exposure to environmental chemicals modify this relationship? (supported by Administrative Supplement from NIH Office of Dietary Supplements).
* How does maternal obesity and adiposity impact biomarkers of reproductive endpoints in newborns, and does this differ in male vs. female babies? (supported by R03 award from NICHD).
* Is perinatal obesity associated with maternal mitochondrial epigenetic disruption and is that related to newborn weight or gestational age at birth? (supported by pilot grant from Michigan Environmental Influences on Child Health Outcomes cohort (ECHO))

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Lecture / Discussion Mon, 26 Sep 2022 11:17:41 -0400 2022-10-04T12:00:00-04:00 2022-10-04T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Oct 4 Interplay of Maternal Diet with Environmental Exposures in Pregnancy (Rita Strakovsky)
Natural Product Discovery and Biosynthesis in the Post-genomic Era (October 4, 2022 4:00pm) https://events.umich.edu/event/94405 94405-21738304@events.umich.edu Event Begins: Tuesday, October 4, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Chembio
Mohammad Seyedsayamdost (Princeton)

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Other Tue, 04 Oct 2022 18:15:24 -0400 2022-10-04T16:00:00-04:00 2022-10-04T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
DCMB / CCMB Weekly Seminar (October 5, 2022 4:00pm) https://events.umich.edu/event/99751 99751-21798643@events.umich.edu Event Begins: Wednesday, October 5, 2022 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract:

Accurately predicting the onset of disease is a major challenge in clinical medicine because the genesis of diseases is generally a complex and dynamic process. Wearable sensor technologies provide an unprecedented opportunity to collect physiological data at orders of magnitude higher high time-resolution than conventional clinical practice. This provides unprecedented opportunities for investigating the dynamics of disease processes and may usher in a new era of real-time, personalized medicine. We have proposed the potential of real-time, continuously measured physiological data as a non-invasive, “digital biomarker” approach for detecting the earliest stages in transition to a disease state. In this talk, I will describe an example of our interdisciplinary team’s work on this topic that uses the early detection and possible prediction of febrile (i.e., fever-associated) adverse events in cancer events as an important application.

Clinical Interests
Prostate Cancer, General Oncology, Biomarkers in Oncology
Research Interests
• Biology of circulating, extracellular nucleic acids and translational applications
• Developing next generation approaches for early detection and monitoring of cancer
• Bioinformatics and computational biology, high-throughput sequencing
• New technologies to enable cancer detection and monitoring

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Lecture / Discussion Mon, 03 Oct 2022 15:21:48 -0400 2022-10-05T16:00:00-04:00 2022-10-05T17:00:00-04:00 Palmer Commons DCMB Seminar Series Lecture / Discussion Muneesh Tewari, MD, PhD
MS / PhD Open House (October 5, 2022 5:00pm) https://events.umich.edu/event/98232 98232-21795760@events.umich.edu Event Begins: Wednesday, October 5, 2022 5:00pm
Location: Palmer Commons
Organized By: U-M College of Pharmacy

Explore programs in drug discovery, delivery, and optimization.

Learn about our PhD programs in:
Medicinal Chemistry
Pharmaceutical Sciences
Clinical Pharmacy Translational Science

and our MS program in Integrated Pharmaceutical Sciences.

The event will include overview presentations regarding each program as well as a poster session featuring research presentations by our graduate students.

The MS/PhD Open House will be hosted in both in-person and virtual formats. We hope that you will make plans to attend!

If you have any questions, please contact Cherie Dotson at crdotson@umich.edu

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Reception / Open House Wed, 07 Sep 2022 14:17:55 -0400 2022-10-05T17:00:00-04:00 2022-10-05T19:00:00-04:00 Palmer Commons U-M College of Pharmacy Reception / Open House Text: advance your education.
DCM&B Tools and Technology Seminar (October 6, 2022 12:00pm) https://events.umich.edu/event/96850 96850-21793401@events.umich.edu Event Begins: Thursday, October 6, 2022 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

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Presentation Mon, 29 Aug 2022 13:40:58 -0400 2022-10-06T12:00:00-04:00 2022-10-06T13:00:00-04:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
Deciphering mechanisms of organismal phosphate regulation (October 6, 2022 12:00pm) https://events.umich.edu/event/98813 98813-21797217@events.umich.edu Event Begins: Thursday, October 6, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

EDUCATION
Massachusetts Institute of Technology, Cambridge, MA, USA
Doctor of Philosophy in Biology, September 2007-June 2014
University of Washington, Seattle, WA, USA
Honors Bachelor of Science in Neurobiology, September 2002-June 2006
POSITIONS AND ACADEMIC APPOINTMENTS
2021-Present Assistant Professor, University of Michigan School of Dentistry
2022-Present Faculty Member, Cellular and Molecular Biology Graduate Program, University of Michigan
2019-2021 Instructor in Medicine, Harvard Medical School, Massachusetts General Hospital, Boston, MA
2017-2019 Research Fellow, Endocrine Unit, Lab of Dr. Michael Mannstadt, MGH, Boston, MA
2015-2017 Postdoctoral Associate, Department of Molecular and Cellular Biology, Lab of Dr. Erin O’Shea,

Harvard University, Cambridge, MA

2007-2014 Graduate Research Fellow, Department of Biology, Lab of Dr. Laurie Boyer, MIT, Cambridge, MA
2006 Research Assistant, Department of Orthobiology, Lab of Dr. Mary Murphy,

National University of Ireland, Galway, Ireland

2005-2006 Undergraduate Research Fellow, Department of Genome Sciences, Lab of Dr. Leo Pallanck,

University of Washington, Seattle, WA

2003-2005 Undergraduate Research Fellow, Department of Biochemistry, Lab of Dr. Brian Kennedy,

University of Washington, Seattle, WA
ACADEMIC AND PROFESSIONAL HONORS
2021 University of Michigan Biological Sciences Scholar, Ann Arbor, MI
2019 Most Outstanding Poster, Bisphosphonates 50th Anniversary Meeting
2018 Endocrine Fellows Foundation Forum Travel Grant, Fellows Forum on Metabolic Bone Disease
2018 AIMM-ASBMR John Haddad Young Investigator Fellow
2017 American Society for Bone and Mineral Research Young Investigator Travel Grant Award,
2019 MIT Vertex Scholar, Cambridge, MA
2007 MIT Presidential Scholar
2006 University of Washington Herschel and Caryl Roman Undergraduate Science Scholar
2006 University of Washington Mary Gates Research Scholar
GRANTS AND FELLOWSHIPS
Current
NIH/NIAMS K99/R00 Pathway to Independence Award,
K99 period: August 2019-Sept 2021, R00 period: Feb 2022-Jan 2025
Title: Deciphering mechanisms of nitrogen-containing bisphosphonates, R00 funding: $249,000/year for 3 years

Previous
2018-2019 NIH T32 Training Grant Trainee, 2018-2019, Endocrinology Division, Massachusetts General Hospital
2017 American Cancer Society Postdoctoral Fellowship, 2017
PUBLICATIONS
Bondeson, D.P., Paolella, B.R., Asfaw, A., Rothberg, M., Skipper, T., Mesa, G., Gonzalez, A., Surface, L.E., Ito, K.,
Kazachkova, M., Colgan, W.N., Warren, A., Dempster, J., Krill-Burger, J., Ericsson, M., Tang, A., Fung, I., Chambers,
E.S., Abdusamad, M., Dumont, N., Doench, J.G., Piccioni, F., Root, D.R., Boehm, J., Hahn, W.C, Mannstadt, M.,
McFarland, J.M., Vazquez, F., Golub, T.R., (2022) Phosphate dysregulation via the XPR1:KIDINS220 protein
complex is a therapeutic vulnerability in ovarian cancer., Nature Cancer, 6:681-695

Surface,L.E., Burrow, D.T., Li, J., Park, J., Kumar, S., Lyu, C., Song, N., Yu, Z., Rajagopal, A., Bae, Y., Lee, B.H.,
Mumm, S., Gu, C., Baker, J.C., Mohseni, M., Sum, M., Huskey, M., Duan, S., Bijanki, V.N., Civitelli, R., Gardner,
M.J., McAndrew, C.M., Ricci, W.M., Gurnett, C.A., Diemer, K., Wan, F., Costantino, C.L., Shannon, K.M., Raje, N.,
Dodson, T.B., Haber, D.A., Carette, J.E., Varadarajan, M., Brummelkamp, T.R., Birsoy, K., Sabatini, D.M., Haller, G.,
Peterson, T.R., (2020) ATRAID regulates the action of nitrogen-containing bisphosphonates on bone. Science
Translational Medicine, 12:544, eaav9166
Yu, Z., Surface, L.E., Park, C.Y., Horlbeck, M.A., Wyant, G.A., Abu-Remaileh, M., Peterson, T.R., Sabatini, D.M.,
Weissman, J.S., O’Shea, E.K., (2018) Identification of a transporter complex responsible for the cytosolic entry of
nitrogen-containing bisphosphonates. Elife 7:e36620
Surface, L.E.*, Fields, P.F*, Subramanian, V., Behmer, R., Udeshi, N., Peach, S.E., Carr, S.A., Jaffe, J.D., Boyer, L.A.
(2016) H2A.Z.1 monoubiquitylation antagonizes BRD2 to maintain poised chromatin in ESCs. Cell Reports, 14, 1142-
1155. *equal contribution
Subramanian, V., Mazumder, A., Surface, L.E., Butty, V.L., Fields, P.A., Alwan, A., Torrey, L., Thai, K.K., Levine,
S.S., Bathe, M., Boyer, L.A. (2013) H2A.Z acidic patch couples chromatin dynamics to regulation of gene expression
programs during ESC differentiation. PLoS Genetics, 9, e1003725
Klattenhoff, C*., Sheuermann, J.C.*, Surface, L.E., Bradley, R.K., Fields, P., Steinhauser, M.L., Ding, H., Butty, V.L.,

Torrey, L., Haas S., Abo, R., Tabebordbar, M., Lee, R.T., Burge, C.B., Boyer, L.A. (2013) Braveheart, a long non-
coding RNA required for cardiovascular lineage commitment. Cell 152, 1-14. *equal contribution

Surface, L.E.*, Thornton, S.R.*, Boyer, L.A. (2010) Polycomb group proteins set the stage for early lineage
commitment. Cell Stem Cell 7, 288-298. *equal contribution
Lockshon, D., Surface L.E., Kerr, E.O., Kaeberlein, M., Kennedy, B.K. (2007). The sensitivity of yeast mutants to
oleic acid implicates the peroxisome and other processes in membrane function. Genetics 175, 77-91.
SERVICE & OUTREACH EXPERIENCE
Member, American Society of Bone and Mineral Research, Early Stage Investigator Committee, 2022-Present
Member, Oral Health Sciences PhD Program Committee University of Michigan, 2022-Present
Abstract Reviewer, American Society of Bone and Mineral Research, Annual Meeting, 2020-Present
Workshop Committee Member, Center for Skeletal Research, 2019-2021
-Plan instructional workshops for the Boston-area skeletal research community.
Grant Reviewer, Seeding Labs (Non-profit science development organization), Boston, MA, 2016-Present
-Review grant applications for instrument access grants provided to laboratories in developing countries
-Contributed to data analysis of existing grants
Mentor, Science Club for Girls, Roxbury, MA, 2015-2019
-Led middle school girls from diverse backgrounds in weekly science clubs on Saturdays to engage them with
science and technology
Postdoc Liason Committee, Harvard Department of Molecular and Cellular Biology, 2015-2017
-Served on a committee that advocates for issues relevant for postdocs and beyond. Advocated for the
department to consider a preprint server policy, and bringing in a more diverse set of scientists for talks.
Science Fair Judge, Quincy High School, Quincy, MA, 2010-2021
-Judged the science fair of a diverse high school near Boston, and spoke with attendees about my own career
path through science.

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Lecture / Discussion Thu, 15 Sep 2022 11:20:30 -0400 2022-10-06T12:00:00-04:00 2022-10-06T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Lecture / Discussion Lauren Surface, PhD
OHS Seminar Series Schedule (October 6, 2022 12:00pm) https://events.umich.edu/event/98131 98131-21795617@events.umich.edu Event Begins: Thursday, October 6, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

OHS Seminar Series Schedule Fall 2022 - Stay tuned for more updates!

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Presentation Tue, 06 Sep 2022 13:16:28 -0400 2022-10-06T12:00:00-04:00 2022-10-06T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Presentation OHS Seminar Series Schedule Fall 2022
EEB Thursday Seminar - Hybrid: Global impacts of the amphibian-killing fungus: a functional genomic view (October 6, 2022 3:00pm) https://events.umich.edu/event/96694 96694-21793092@events.umich.edu Event Begins: Thursday, October 6, 2022 3:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Our weekly seminar series featuring internal and external speakers in the field of ecology and evolutionary biology. This seminar will be in-person and livestreaming on Zoom (link this page).

Abstract:
Two fungal pathogens have had devastating effects on amphibian biodiversity at a global scale. I will review some of these impacts and explore, through functional genomic studies, the mechanisms of host-pathogen interactions that underlie resistance or susceptibility in host species. I will then describe our efforts to rediscover some of the species lost to this pathogen in Brazil.

Contact eebsemaccess@umich.edu for Zoom password at least 2 hours prior to event.

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Workshop / Seminar Tue, 04 Oct 2022 08:55:36 -0400 2022-10-06T15:00:00-04:00 2022-10-06T16:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Frog being studied by the lab. Photo credit: Kelly Zamudio
Electrifying Material and Organic Synthesis (October 6, 2022 4:00pm) https://events.umich.edu/event/95988 95988-21791685@events.umich.edu Event Begins: Thursday, October 6, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Analytical
Long Luo (Wayne State University)

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Other Thu, 06 Oct 2022 18:15:24 -0400 2022-10-06T16:00:00-04:00 2022-10-06T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
MCDB Seminar > Some assembly required: How to build a meiotic DNA breaking machine (October 7, 2022 12:00pm) https://events.umich.edu/event/98602 98602-21796959@events.umich.edu Event Begins: Friday, October 7, 2022 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: JK Nandakumar

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Workshop / Seminar Fri, 30 Sep 2022 13:23:40 -0400 2022-10-07T12:00:00-04:00 2022-10-07T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials and cartoon microscope
New AI in Science Postdoctoral Fellowship Program Town Hall Meeting #1 (October 10, 2022 10:00am) https://events.umich.edu/event/99913 99913-21798876@events.umich.edu Event Begins: Monday, October 10, 2022 10:00am
Location: BBB
Organized By: Michigan Institute for Data Science

MIDAS is excited to announce a new AI in Science Postdoctoral Fellowship Program at U-M, which will launch this semester!

Funded by an as-yet-unnamed donor, this campus-wide program, managed by MIDAS, focuses on enabling major research breakthroughs in science and engineering through the adoption of cutting-edge AI methodologies. The program will accept 10 new postdocs each year for the next six years.

On October 10th, we will hold two town hall meetings to introduce the new AI in Science Postdoctoral Fellowship Program at Michigan. The program leadership team will provide details of the program, outline the application process, and answer questions. There will also be networking time so that faculty members interested in being mentors can talk with each other, and potential candidates can connect with faculty mentors.
To support attendees on North and Central campus, we will offer two meetings with identical content:

Meeting #1 (North Campus): Oct. 10, 10am - 12pm, Tishman Lobby, Bob and Betty Beyster Building, 2260 Hayward Street.

Meeting #2 (Central Campus): Oct.10, 12:30pm - 2:30pm, Weiser Hall 10th floor, 500 Church Street.

Sign up to attend a Town Hall session

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Presentation Thu, 06 Oct 2022 11:36:59 -0400 2022-10-10T10:00:00-04:00 2022-10-10T12:00:00-04:00 BBB Michigan Institute for Data Science Presentation Town Hall Meeting
New AI in Science Postdoctoral Fellowship Program Town Hall Meeting #2 (October 10, 2022 12:30pm) https://events.umich.edu/event/99915 99915-21798880@events.umich.edu Event Begins: Monday, October 10, 2022 12:30pm
Location: Weiser Hall
Organized By: Michigan Institute for Data Science

MIDAS is excited to announce a new AI in Science Postdoctoral Fellowship Program at U-M, which will launch this semester!

Funded by an as-yet-unnamed donor, this campus-wide program, managed by MIDAS, focuses on enabling major research breakthroughs in science and engineering through the adoption of cutting-edge AI methodologies. The program will accept 10 new postdocs each year for the next six years.

On October 10th, we will hold two town hall meetings to introduce the new AI in Science Postdoctoral Fellowship Program at Michigan. The program leadership team will provide details of the program, outline the application process, and answer questions. There will also be networking time so that faculty members interested in being mentors can talk with each other, and potential candidates can connect with faculty mentors.
To support attendees on North and Central campus, we will offer two meetings with identical content:

Meeting #1 (North Campus): Oct. 10, 10am - 12pm, Tishman Lobby, Bob and Betty Beyster Building, 2260 Hayward Street.

Meeting #2 (Central Campus): Oct.10, 12:30pm - 2:30pm, Weiser Hall 10th floor, 500 Church Street.

Sign up to attend a Town Hall session

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Presentation Thu, 06 Oct 2022 11:41:41 -0400 2022-10-10T12:30:00-04:00 2022-10-10T14:30:00-04:00 Weiser Hall Michigan Institute for Data Science Presentation Town Hall Meeting
RNA Innovation Seminar: Polly Hsu, Michigan State University (October 10, 2022 4:00pm) https://events.umich.edu/event/97619 97619-21794812@events.umich.edu Event Begins: Monday, October 10, 2022 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Polly Hsu, Ph.D.
Assistant Professor
Biochemistry and Molecular Biology
Michigan State University

Keywords: translation, uORFs, nonsense-mediated decay

Abstract: 30-70% of mRNAs in humans, mice and plants contain short ORFs, called upstream ORFs (uORFs), in their 5’ leader sequences. The translation of uORFs is expected to repress the protein synthesis of their downstream main ORF (mORF) and to trigger mRNA degradation, presumably through nonsense-mediated decay (NMD). I will share our current progress investigating the global and gene-specific mechanisms by which uORFs regulate gene expression in Arabidopsis and tomato. I will discuss 1) different classes of uORFs revealed by Ribo-seq, 2) the roles of uORFs on transcription factor and protein kinase genes, 3) the mRNA stability of uORF-containing genes, and 4) cellular regulatory mechanisms to include or avoid uORFs on mRNA sequences.

HYBRID SEMINAR:
In-person: BSRB, ABC seminar rooms
zoom option: https://umich.zoom.us/webinar/register/WN_04eu5WLkS56ZK169pLUFdg

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Lecture / Discussion Tue, 20 Sep 2022 15:39:14 -0400 2022-10-10T16:00:00-04:00 2022-10-10T17:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion Polly Hsu, Michigan State University
25th anniversary screening of GATTACA (October 10, 2022 6:00pm) https://events.umich.edu/event/99458 99458-21798226@events.umich.edu Event Begins: Monday, October 10, 2022 6:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

This October marks the 25th anniversary of the theatrical release of GATTACA, a science fiction film that addresses the potential complications of a world in which genetic information can be rapidly analyzed and manipulated. Since the movie’s release, many of the tools anticipated by the film have become a reality and some aspects of the genetic selection processes proposed are used in reproductive clinical practice today.

To highlight this brave new world, the Departments of Neurology and Human Genetics within Michigan Medicine and the Center for RNA Biomedicine are sponsoring a one-time showing of GATTACA at the Michigan Theater as part of the “Science on Screen” series. The movie will be shown at 7pm on Monday October 10th (Columbus Day/Indigenous People’s day) and will be preceded by a 1 hour panel discussion starting at 6pm among 4 experts on the technologies and ethics of genetic information.


Where: Michigan Theater (603 E Liberty St, Ann Arbor, MI)

When: 6PM: Public Panel Discussion on Science and Ethics of GATTACA in 2022

· Scott Roberts, Ph.D., M.A. Professor, Michigan School of Public Health. Director, Michigan Alzheimer's Disease Center Outreach, Recruitment, and Education Core.

· Kayte Spector-Bagdady, JD, Mbioethics. Associate Director, Center for Bioethics & Social Sciences in Medicine. Assistant Professor, OBGYN Michigan Medicine.

· Peter Todd, MD, PhD. Professor of Neurology and Director, Neurogenetics Clinical Research Program, Michigan Medicine.

· Yan Zhang, Ph.D. Assistant Professor of Biochemistry, Michigan Medicine. Expert on CRISPR gene editing technologies.

7pm: Screening of GATTACA (run time 1h 46m).

Who? This event is open to the public. Families are welcome (the film is rated PG-13).

RSVP?: Tickets can also be purchased on the day of the show at the theater ($10.50 adults, $8.50 students with valid ID)

Questions?: Feel free to email petertod@umich.edu with any further questions, comments or concerns.

We look forward to seeing you at the show and discussion.

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Presentation Thu, 06 Oct 2022 14:21:41 -0400 2022-10-10T18:00:00-04:00 2022-10-10T21:00:00-04:00 Off Campus Location Center for RNA Biomedicine Presentation 25th anniversary screening of GATTACA with Panel Discussion
CGIS Study Abroad Fair (October 11, 2022 12:00pm) https://events.umich.edu/event/96881 96881-21793528@events.umich.edu Event Begins: Tuesday, October 11, 2022 12:00pm
Location: Michigan Union
Organized By: Center for Global and Intercultural Study

Learn about 115+ programs in over 45 countries, ask about U-M faculty-led programs, and figure out which program can help satisfy your major/minor requirements. CGIS has programs ranging from a few weeks to an academic year! Meet with CGIS advisors, staff from the Office of Financial Aid and the LSA Scholarship Office, CGIS Alumni, and other on-campus offices who can help you select a program that works best for you.

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Fair / Festival Tue, 04 Oct 2022 11:40:54 -0400 2022-10-11T12:00:00-04:00 2022-10-11T16:00:00-04:00 Michigan Union Center for Global and Intercultural Study Fair / Festival Join us for the CGIS Study Abroad Fair on October 11, 2022
EEB Tuesday Lunch Seminar - Hybrid: Artificial reefs to promote primary production in tropical seagrass ecosystems - a simulation study using individual-based modelling (October 11, 2022 12:00pm) https://events.umich.edu/event/97017 97017-21793694@events.umich.edu Event Begins: Tuesday, October 11, 2022 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Our weekly lunch seminar series featuring internal speakers in the field of ecology and evolutionary biology.

Abstract
Tropical seagrass ecosystems are among the most productive ecosystems worldwide, yielding tremendous services for coastal communities. Yet, they are among the most impaired from anthropogenic stressors. Understanding factors controlling primary production is fundamental for the protection, management, and restoration of these ecosystems. Artificial reefs are a widely used marine management tool, creating biogeochemical hotspots via aggregating fish that fuel local primary production. However, testing whether increased local production affects primary production at ecosystem scale remains empirically challenging. Thus, we implemented a spatially explicit individual-based simulation model to test how aggregating fish on artificial reefs affect seagrass primary production at various scales.

This seminar will be in-person and livestreaming on Zoom (link this page).

Contact eebsemaccess@umich.edu for password at least two hours prior to the event.

Image credit: Allgeier Lab

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Workshop / Seminar Wed, 05 Oct 2022 11:56:32 -0400 2022-10-11T12:00:00-04:00 2022-10-11T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Artificial reef built with cement cinder blocks with many fish and abundant seagrass growing around the reef
Single-Molecule Cell Biology Reveals the Molecular Mechanisms of Genome Integrity Pathways in Cancer Cells-Department of Biological Chemistry Seminar Series (October 11, 2022 12:00pm) https://events.umich.edu/event/99068 99068-21797521@events.umich.edu Event Begins: Tuesday, October 11, 2022 12:00pm
Location: Medical Science Unit I
Organized By: Biological Chemistry

Dr. Jens Schmidt will present a seminar for the Department of Biological Chemistry on Tuesday October 11th at 12:00pm.

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Workshop / Seminar Tue, 20 Sep 2022 08:19:58 -0400 2022-10-11T12:00:00-04:00 2022-10-11T13:00:00-04:00 Medical Science Unit I Biological Chemistry Workshop / Seminar
Water and Public Health: Inequity and Affordability (October 11, 2022 12:00pm) https://events.umich.edu/event/99252 99252-21797776@events.umich.edu Event Begins: Tuesday, October 11, 2022 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

With Monica-Lewis Patrick (We the People of Detroit), Mary Grant (Food & Water Watch) and Dr. Marcela González Rivas (University of Pittsburgh). Amy Schulz (M-LEEaD CEC Core Leader, UM SPH) will moderate.

Zoom webinar registration required
https://www.google.com/url?q=https://umich.zoom.us/webinar/register/WN_1kLh0_GGQmWFdM3I0DhG6Q&sa=D&source=calendar&ust=1664288912093677&usg=AOvVaw0B81Oj7JvacmxDJP94mbxI

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Lecture / Discussion Fri, 23 Sep 2022 15:48:30 -0400 2022-10-11T12:00:00-04:00 2022-10-11T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Residents & Researchers Tuesday Talks
EMERSE Meeting Series (October 11, 2022 1:00pm) https://events.umich.edu/event/98192 98192-21795695@events.umich.edu Event Begins: Tuesday, October 11, 2022 1:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Speaker:
Mark Beno, MSM
Executive Director, Cleveland Institute for Computational Biology,
School of Medicine, Case Western Reserve University

The Electronic Medical Record Search Engine (EMERSE) was installed at University Hospitals of Cleveland (UH) in 2021 by the Cleveland Institute for Computational Biology (CICB), a collaboration between Case Western Reserve University (CWRU) and UH.  At present, EMERSE contains indexed medical notes from 2018 through present for over 1.7 million UH patients.  This presentation will discuss the strategies we employed to successfully install EMERSE, the lessons-learned in rolling out EMERSE to research and operational teams, some research success stories since EMERSE adoption, and the additional tools we have developed as add-ons to the EMERSE application that we use internally for tracking EMERSE metrics and plan to share with the broader EMERSE community.

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Lecture / Discussion Tue, 06 Sep 2022 23:35:08 -0400 2022-10-11T13:00:00-04:00 2022-10-11T14:00:00-04:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion EMERSE logo
Addicted to Salt: Mass Spectrometry Reveals Chlorine Chemistry Degrading Wintertime Air Quality (October 11, 2022 4:00pm) https://events.umich.edu/event/96496 96496-21792592@events.umich.edu Event Begins: Tuesday, October 11, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Chlorine radicals (Cl·) readily react with the greenhouse gas methane and other volatile hydrocarbons, facilitating the production of ozone and particulate matter that degrade air quality and harm human health. An important chlorine source is the photolysis of nitryl chloride (ClNO2(g)), which is formed in the polluted atmosphere at night through the reaction of dinitrogen pentoxide (N2O5(g)) with chloride-containing surfaces. The importance of ClNO2 in marine and coastal locations is well-recognized due to presence of sea spray aerosol. However, ClNO2 was unexpectedly detected in regions far inland from the ocean, with wintertime levels rivaling marine locations. We tackled investigation of this unresolved chemistry through a series of field-based measurements of atmospheric trace gases, individual particles, and snow, complemented by “lab-in-the-field” experiments and modeling, in wintertime urban environments. Our novel single-particle measurements, combined with online ion chromatography, identified road salt aerosol as the dominant chloride source. ClNO2 production from the reaction of N2O5 with road salt aerosol was quantitatively observed by chemical ionization mass spectrometry. We also exposed road salt-contaminated snow to synthesized N2O5 and observed ClNO2 production, discovering yet another unique chloride source in the wintertime inland environment. We showed that ClNO2 produced from the saline snowpack alters air quality even hundreds of meters above the snow-covered ground. Our discovery of the connection between road salt and wintertime air quality has profound implications for wintertime atmospheric chemistry and decision-making regarding deicing practices, as tens of millions of tons of road salt are spread on roadways for deicing globally each winter.


Kerri Pratt

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Other Tue, 11 Oct 2022 18:15:21 -0400 2022-10-11T16:00:00-04:00 2022-10-11T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
CPOD Seminar Talk: Alex Hughes, PhD (UPenn)"Interpreting geometric rules of early kidney formation for synthetic morphogenesis" (October 11, 2022 4:00pm) https://events.umich.edu/event/98601 98601-21796958@events.umich.edu Event Begins: Tuesday, October 11, 2022 4:00pm
Location: Off Campus Location
Organized By: Center for Cell Plasticity and Organ Design

Tuesday, October 11, 2022 4:00 pm
Center for Cell Plasticity and Organ Design presents:

Alex Hughes, PhD
Assistant Professor
Department of Bioengineering
University of Pennsylvania

Seminar entitled: "Interpreting geometric rules of early kidney formation for synthetic morphogenesis"

In-Person: BSRB ABC Seminar Rooms
Zoom Meeting Option ID: 932 944 30678

Faculty Host: Claudia Loebel, MD PhD, Assistant Professor, Materials Science & Engineering

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Lecture / Discussion Mon, 12 Sep 2022 21:04:22 -0400 2022-10-11T16:00:00-04:00 2022-10-11T17:00:00-04:00 Off Campus Location Center for Cell Plasticity and Organ Design Lecture / Discussion Hughes
Futures in Research, Science, and Teaching - General meeting (October 11, 2022 4:00pm) https://events.umich.edu/event/96044 96044-21791848@events.umich.edu Event Begins: Tuesday, October 11, 2022 4:00pm
Location:
Organized By: Futures in Research, Science, Teaching - FIRST

General meetings take place every other Tuesday from September 13 to December 6th. Events include:

September 13th: Pathways in Research (Graduate student/Faculty panel)
September 27th: Mixer (food provided)
October 11th: Poster design and presentation
October 25th: Applying to graduate school - application components and essay writing advice
November 8th: Finding paid summer and post-baccalaureate research opportunities
November 22nd: Faculty talk
December 6th: Mixer

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Meeting Mon, 12 Sep 2022 12:26:57 -0400 2022-10-11T16:00:00-04:00 2022-10-11T17:00:00-04:00 Futures in Research, Science, Teaching - FIRST Meeting Event flyer detailing date, time, and location: September 13th at 4 pm, BSB 1010
Poster Design Workshop (October 11, 2022 4:00pm) https://events.umich.edu/event/99872 99872-21798816@events.umich.edu Event Begins: Tuesday, October 11, 2022 4:00pm
Location: Biological Sciences Building
Organized By: Futures in Research, Science, Teaching - FIRST

A short presentation on STEM poster design, followed by researchers and graduate students sharing personal examples. Topics will included formatting, narrating your research story, and designing a poster that works equally well presented or read on its own.

RSVP: https://forms.gle/DVGvnsSXhtCEBeWy6

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Workshop / Seminar Wed, 05 Oct 2022 13:46:21 -0400 2022-10-11T16:00:00-04:00 2022-10-11T17:00:00-04:00 Biological Sciences Building Futures in Research, Science, Teaching - FIRST Workshop / Seminar FIRST Logo
Information Session Webinar- Michigan Program in Survey and Data Science (MPSDS) (October 12, 2022 3:00pm) https://events.umich.edu/event/98336 98336-21796508@events.umich.edu Event Begins: Wednesday, October 12, 2022 3:00pm
Location: Off Campus Location
Organized By: Michigan Program in Survey and Data Science

Wednesday, October 12, 2002
3:00 - 4:00pm
Registration is required.

Please join us October 12, 2022 to learn about the Michigan Program in Survey and Data Science. The speaker will be Dr. Brady West.

Advance registration is required, https://bit.ly/3d3upwR

The Michigan Program in Survey and Data Science (MPSDS) offers graduate degrees that combine ideas and techniques for producing and analyzing data about humans and our society. Joint us to launch your career in this exciting and rewarding field in which scientists interpret the world through data.

The University of Michigan Program in Survey Methodology was established in 2001 seeking to train future generations of survey and data scientists. In 2021, we changed our name to the Michigan Program in Survey and Data Science. Our curriculum is concerned with a broad set of data sources including survey data, but also including social media posts, sensor data, and administrative records, as well as analytic methods for working with these new data sources. And we bring to data science a focus on data quality — which is not at the center of traditional data science. The new name speaks to what we teach and work on at the intersection of social research and data. The program offers doctorate and master of science degrees and a certificate through the University of Michigan. The program's home is the Institute for Social Research, the world's largest academically-based social science research institute.

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Presentation Thu, 08 Sep 2022 14:38:06 -0400 2022-10-12T15:00:00-04:00 2022-10-12T16:00:00-04:00 Off Campus Location Michigan Program in Survey and Data Science Presentation MPSDS Informational Session Webinar
Ab-initio solid state chemistry as a new frontier of theory (October 12, 2022 4:00pm) https://events.umich.edu/event/96497 96497-21792593@events.umich.edu Event Begins: Wednesday, October 12, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The search for new materials is at the core of the technological advancement of our society. While many newly synthesized materials can be analyzed by current quantum chemical techniques, mostly based on the density functional theory (DFT), there is a large number of materials that cannot be treated successfully by existing methodologies. This is mostly due to the presence of strong electron correlation, relativistic effects, and disorder. These materials require a post-DFT description that explicitly includes electron-electron interactions.

In my talk, I will discuss current theoretical challenges in the study of solid state materials and I will describe my group's contributions to the development of post-DFT methods. In the first part, I will present the newest relativistic methodologies for solids. In the second part, I will talk about the treatment of strongly correlated electrons residing in d- and f-orbitals of crystals with transition metals. Finally, I will sketch future directions for computational ab-initio solid state chemistry.


Dominika Zgid

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Other Wed, 12 Oct 2022 18:15:27 -0400 2022-10-12T16:00:00-04:00 2022-10-12T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
DCMB / CCMB Weekly Seminar (October 12, 2022 4:00pm) https://events.umich.edu/event/99377 99377-21797973@events.umich.edu Event Begins: Wednesday, October 12, 2022 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract:

Our current understanding of how genes are regulated is akin to solving a jigsaw puzzle. Many factors governing gene expression have been identified, and researchers have collected a wide variety of related datasets. However, how these "parts" are pieced together to function as a whole remains unclear. In this talk, I will discuss our research to develop and apply state-of-the-art machine learning methods to genomics datasets to attempt to put together the pieces from the data. I will cover our work using deep learning architecture that captures the data's underlying structure to integrate datasets and connect them to gene expression via the prediction task. We also interpret the prediction results and tie them back to contributing factors to develop potential hypotheses related to gene regulation. I will then move from bulk data to the single-cell data domain and discuss methods to perform unsupervised integration of different types of single-cell experiments. This talk aims to highlight our research direction's potential to reveal the important gene regulatory mechanisms in characterizing cell types and diseases from the collected data.

Bio:

Ritambhara Singh is an Assistant Professor in the Computer Science department and a faculty member of the Center for Computational Molecular Biology at Brown University. Her research lab works at the intersection of machine learning and biology. Prior to joining Brown, Singh was a post-doctoral researcher in the Noble Lab at the University of Washington. She completed her Ph.D. in 2018 from the University of Virginia with Dr. Yanjun Qi as her advisor. Her research has involved developing machine learning algorithms for the analysis of biological data as well as applying deep learning models to novel biological and biomedical applications. She recently received the NHGRI Genomic Innovator Award for developing deep learning methods to integrate and model genomics datasets. URL: https://vivo.brown.edu/display/rsingh47

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Lecture / Discussion Tue, 27 Sep 2022 09:32:07 -0400 2022-10-12T16:00:00-04:00 2022-10-12T17:00:00-04:00 Palmer Commons DCMB Seminar Series Lecture / Discussion Ritambhara Singh, Asst. Professor (Brown University)
DCM&B Tools and Technology Seminar (October 13, 2022 12:00pm) https://events.umich.edu/event/96851 96851-21793402@events.umich.edu Event Begins: Thursday, October 13, 2022 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

The current COVID-19 pandemic and the previous SARS/MERS outbreaks of 2003 and 2012 have resulted in a series of major global public health crises. We must integrate the large and exponentially growing amount of heterogeneous coronavirus data to better understand coronaviruses and associated disease mechanisms, in the interest of developing effective and safe vaccines and drugs. Ontologies play an important role in standard-based knowledge and data representation, integration, sharing, and analysis. Accordingly, we initiated the development of the community-based Coronavirus Infectious Disease Ontology (CIDO) in early 2020.

Tool Link: https://github.com/CIDO-ontology/cido

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

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Presentation Mon, 15 Aug 2022 10:49:10 -0400 2022-10-13T12:00:00-04:00 2022-10-13T13:00:00-04:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
Glucose metabolism in bone biology and diabetic osteopenia (October 13, 2022 12:00pm) https://events.umich.edu/event/98788 98788-21797183@events.umich.edu Event Begins: Thursday, October 13, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

I have been studying skeletal development and homeostasis for over 25 years. I am interested in understanding the molecular and metabolic regulation of skeletal cell types both in the embryo and in adults under normal or pathological conditions. The work has led to new insights into the metabolic features of chondrocytes, osteoblasts and osteoclasts. Studies of Hh, Wnt, Bmp and Notch signaling have uncovered metabolic reprogramming as a common link for developmental signals to regulate the fate and activity of skeletal cells. In a separate line of work, we have sought to elucidate the molecular identify and regulation of mesenchymal stem and progenitor cells in bone. This pursuit has led to the discovery of Gli1+ mesenchymal progenitors as the main source for osteoblasts in growing bones (Shi et al., 2017, Nat Commun., PMC
5725597). More recently, we have demonstrated a critical role for the Gli1+ progenitors in mediating the bone
anabolic role of teriparatide, the main bone anabolic therapy for osteoporosis (Shi et al, 2021, Cell Rep, in
press). The current proposal extends our work on mesenchymal progenitors and builds on the discovery of a
potential adipo-osteoprogenitor in the adult bone marrow. Completion of the proposed study is expected to
uncover the role of the newly discovered progenitors in bone homeostasis, skeletal aging and diabetic
osteopenia.

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Lecture / Discussion Thu, 15 Sep 2022 09:48:26 -0400 2022-10-13T12:00:00-04:00 2022-10-13T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Lecture / Discussion Fanxin Long, PhD William W. Smith Endowed Chair in Pediatric Genomic Research The Children's Hospital of Philadelphia Professor of Orthopedic Surgery University of Pennsylvania
OHS Seminar Series Schedule (October 13, 2022 12:00pm) https://events.umich.edu/event/98131 98131-21795618@events.umich.edu Event Begins: Thursday, October 13, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

OHS Seminar Series Schedule Fall 2022 - Stay tuned for more updates!

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Presentation Tue, 06 Sep 2022 13:16:28 -0400 2022-10-13T12:00:00-04:00 2022-10-13T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Presentation OHS Seminar Series Schedule Fall 2022
Celebrate Invention (October 13, 2022 1:00pm) https://events.umich.edu/event/98346 98346-21796522@events.umich.edu Event Begins: Thursday, October 13, 2022 1:00pm
Location: Michigan Union
Organized By: Innovation Partnerships

Celebrate University of Michigan inventors and the growing impact of U-M innovations!

Don’t miss this year’s annual Celebrate Invention highlighting demonstrations from promising U-M startups, networking opportunities at the ecosystem fair, panel discussions featuring prominent inventors and alumni, and the presentation of the Distinguished University Innovator of the Year Award.

Thursday, October 13
1:00–6:00pm
Michigan Union, 2nd Floor
530 S. State Street, Ann Arbor, MI 48109

Part of Ann Arbor SPARK's a2Tech360, Celebrate Invention is free and open to the public. Register today at *https://myumi.ch/DJNbM!*

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1:00–3:00pm: Panel Sessions & Ecosystem Fair

3:00–6:00pm: Reception, Rogel Ballroom, Michigan Union, 2nd Floor

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Reception / Open House Thu, 08 Sep 2022 17:06:20 -0400 2022-10-13T13:00:00-04:00 2022-10-13T18:00:00-04:00 Michigan Union Innovation Partnerships Reception / Open House Image of the Celebrate Invention logo on a blue background.
EEB Thursday Seminar: CANCELLED (October 13, 2022 3:00pm) https://events.umich.edu/event/96695 96695-21793093@events.umich.edu Event Begins: Thursday, October 13, 2022 3:00pm
Location:
Organized By: Ecology and Evolutionary Biology

See you next week!

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Workshop / Seminar Tue, 27 Sep 2022 15:44:10 -0400 2022-10-13T15:00:00-04:00 2022-10-13T16:00:00-04:00 Ecology and Evolutionary Biology Workshop / Seminar
TBA (October 13, 2022 4:00pm) https://events.umich.edu/event/94377 94377-21736322@events.umich.edu Event Begins: Thursday, October 13, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Analytical
Mark Schoenfisch

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Other Fri, 09 Sep 2022 12:16:25 -0400 2022-10-13T16:00:00-04:00 2022-10-13T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
MCDB Seminar> Neural circuits underlying social dominance (October 14, 2022 12:00pm) https://events.umich.edu/event/98605 98605-21796962@events.umich.edu Event Begins: Friday, October 14, 2022 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: MCDB DEI Committee

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Workshop / Seminar Fri, 30 Sep 2022 13:28:25 -0400 2022-10-14T12:00:00-04:00 2022-10-14T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials and cartoon microscope
RNA Therapeutics Seminar: John Cooke, M.D., Ph.D., Medical Director, Center for RNA Therapeutics, Houston Methodist (October 17, 2022 4:00pm) https://events.umich.edu/event/97620 97620-21794813@events.umich.edu Event Begins: Monday, October 17, 2022 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

HYBRID SEMINAR

In-person: BSRB, ABC with zoom option: https://umich.zoom.us/webinar/register/WN_ZbUxbRLaTS2Bt1t-_q5pzg

Abstract: mRNA therapeutics is a disruptive therapeutic technology, as small biotech startups, as well as academic groups, can rapidly develop new and personalized mRNA constructs. In the Texas Medica Center, we have established a Center for RNA Therapeutics that comprises faculty innovators, as well as a translational assembly line to bring great RNA ideas to life. Academic groups and small companies work with us as we innovate, design, synthesize, purify, encapsulate and test mRNA therapies. In addition to providing pre-clinical GLP testing, we have established cGMP-compliant manufacturing capability and quality control methods to support pre-clinical GLP studies and phase I clinical trials; and have a first-in-man phase 1 clinical trial unit. To support phase II and phase III trials, and commercialization, we have licensed our proprietary manufacturing processes to VGXI Inc, a local company with large-batch manufacturing capabilities for DNA-based gene therapies. With this collaboration, we have built a seamless transition for academic groups and small companies to go from pre-clinical development and first-in-man clinical trials supported by our hospital-based program, to late-stage clinical trials and commercialization supported by our industry partner VGXI, Inc.

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Lecture / Discussion Fri, 07 Oct 2022 12:42:11 -0400 2022-10-17T16:00:00-04:00 2022-10-17T17:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion John Cooke, M.D., Ph.D., Houston Methodist
Novartis Symposium (October 18, 2022 9:00am) https://events.umich.edu/event/94715 94715-21762085@events.umich.edu Event Begins: Tuesday, October 18, 2022 9:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


Peter Seeberger(Max-PLanck Institute for Colloids and Interfaces) , Ellen Sletten(UCLA) , Atwood Cheung

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Other Tue, 18 Oct 2022 18:15:26 -0400 2022-10-18T09:00:00-04:00 2022-10-18T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Capturing native and intermediate states at atomic resolution by cryoEM- Department of Biological Chemistry Seminar Series (October 18, 2022 12:00pm) https://events.umich.edu/event/99069 99069-21797522@events.umich.edu Event Begins: Tuesday, October 18, 2022 12:00pm
Location: Medical Science Unit I
Organized By: Biological Chemistry

Dr. Zhou will present the Department of Biological Chemistry Seminar on Tuesday October 18th at 12pm

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Workshop / Seminar Tue, 20 Sep 2022 08:34:02 -0400 2022-10-18T12:00:00-04:00 2022-10-18T13:00:00-04:00 Medical Science Unit I Biological Chemistry Workshop / Seminar
Use of a small animal model to understand how and why we sleep (October 19, 2022 9:30am) https://events.umich.edu/event/98293 98293-21796454@events.umich.edu Event Begins: Wednesday, October 19, 2022 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

CDB Seminar Series

We are pleased to announce that Amita Sehgal, Ph.D. will present her talk titled "How Circadian Rhythms & Sleep Interact with Basic Physiology", on October 19, 2022 at 9:30 am, at Kahn Auditorium in BSRB and via live stream: Meeting Link: https://umich.zoom.us/s/93126459104

Hosted By:
Swathi Yadlapalli

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Lecture / Discussion Wed, 12 Oct 2022 12:23:55 -0400 2022-10-19T09:30:00-04:00 2022-10-19T10:30:00-04:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion Use of a small animal model to understand how and why we sleep
DCMB / CCMB Weekly Seminar (October 19, 2022 4:00pm) https://events.umich.edu/event/99817 99817-21798751@events.umich.edu Event Begins: Wednesday, October 19, 2022 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract:
Genome-wide association studies (GWAS) successfully identified more than a hundred genomic regions that contribute to schizophrenia risk. However, extracting biological mechanisms from GWAS is a challenge, because the majority of common risk variants reside in noncoding regions of the genome. In this talk, I will outline how high-resolution 3D maps of chromatin contacts in the human brain permit large-scale annotation of non-coding variants. In particular, I will introduce a novel platform that my lab has developed, Hi-C-coupled MAGMA (H-MAGMA), that annotates GWAS by incorporating chromatin interaction profiles from human brain tissue. While H-MAGMA identified neurobiologically relevant target genes for psychiatric disorders, application of H-MAGMA to schizophrenia GWAS identified thousands of genes to be associated with schizophrenia, necessitating the need for refining variants. To this end, we performed a massively parallel reporter assay (MPRA) on schizophrenia risk variants, from which we detected 440 variants with allelic regulatory activity. Characterization of these functional regulatory variants provided previously unknown regulatory principles of schizophrenia.

Short bio:
Hyejung Won is an Assistant Professor in the Department of Genetics and Neuroscience Center at the University of North Carolina at Chapel Hill. She received her B.S. and Ph.D. in Biology from Korea Advanced Institute of Science and Technology (KAIST), where she conducted research revealing the underlying mechanism of neurodevelopmental conditions using genetically modified mice under the supervision of Dr. Eunjoon Kim. She then joined Dr. Dan Geschwind’s group at UCLA, where she established Hi-C, a genome-wide chromosome conformation capture technology, and generated chromatin interaction profiles from the developing and adult human brain. Her lab leverages the genomics approach to bridge the gap between genetic risk factors and neurobiological mechanisms by mapping genetic variants of unknown function to the genes that they regulate, and identifying how dysfunctional gene regulation contributes to disease pathogenesis. Hyejung is the recipient of the NIH Director’s New Innovator Award, HHMI Gilliam Fellowship, NIH Pathway to Independence Award, and a NARSAD Young Investigator Award. She is also an active participant of the Impact of Genomic Variation on Function (IGVF) and PsychENCODE consortia.

Zoom link: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Lecture / Discussion Tue, 04 Oct 2022 13:40:56 -0400 2022-10-19T16:00:00-04:00 2022-10-19T17:00:00-04:00 Palmer Commons DCMB Seminar Series Lecture / Discussion Hyejung Won, PhD
Complex Systems Seminar | SARS-CoV-2 invasion dynamics and disease development: insights from viral sequences (October 20, 2022 11:30am) https://events.umich.edu/event/100139 100139-21799258@events.umich.edu Event Begins: Thursday, October 20, 2022 11:30am
Location: Weiser Hall
Organized By: The Center for the Study of Complex Systems

ROOM 747 Weiser Hall
This talk will be hybrid, with improved function.
ZOOM https://umich.zoom.us/j/96616169868
Password: CSCS (all caps)

Abstract : The unfolding of the SARS-CoV-2 pandemic led to tremendous sequencing efforts, with tens of millions of viral sequences now publicly available on platforms such as GISAID for quantitative analysis by researchers worldwide. These sequences can be informative of the timing of viral emergence in regions, patterns of geographic spread, epidemiological dynamics, and viral adaptation. They can also be informative of the ways in which viral populations evolve at various scales, from within-host, to between-host, to the host population level. In this talk, I will first present some of my group’s recent work on using SARS-CoV-2 sequence data to infer early viral invasion dynamics into a region when viral genetic diversity is still extremely limited. I will then present our research focused on using SARS-CoV-2 sequence data from established transmission pairs to quantify natural exposure doses and therewith to assess the plausibility that dose could impact the severity of a COVID infection.

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Workshop / Seminar Mon, 17 Oct 2022 09:47:19 -0400 2022-10-20T11:30:00-04:00 2022-10-20T13:00:00-04:00 Weiser Hall The Center for the Study of Complex Systems Workshop / Seminar Katia Koelle
DCM&B Tools and Technology Seminar (October 20, 2022 12:00pm) https://events.umich.edu/event/96852 96852-21793403@events.umich.edu Event Begins: Thursday, October 20, 2022 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

"Molecular representation has an important implication on biomedical and other chemically related studies, and this talk could serve as a brief introduction to the broad field of representation techniques for molecules like drugs. This talk mainly introduces several widely used molecular representation methods, along with some examples of the implementation and applications for those representation methods."

This presentation will be given remotely, with the livestream available for group viewing in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

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Presentation Mon, 15 Aug 2022 10:52:38 -0400 2022-10-20T12:00:00-04:00 2022-10-20T13:00:00-04:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
LHS Collaboratory (October 20, 2022 12:00pm) https://events.umich.edu/event/96028 96028-21791725@events.umich.edu Event Begins: Thursday, October 20, 2022 12:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Speakers:
Alex John London, PhD
Professor of Ethics and Philosophy
Director of the Center for Ethics and Policy at Carnegie Mellon University
Explainability Is Not the Solution to Structural Challenges to AI in Medicine

Explainability is often treated as a necessary condition for ethical applications of artificial intelligence (AI) in Medicine. In this brief talk I survey some of the structural challenges facing the development and deployment of effective AI systems in health care to illustrate some of the limitations to explainability in addressing these challenges. This talk builds on prior work (London 2019, 2022) to illustrate how ambitions for AI in health care likely require significant changes to key aspects of health systems.

Melissa McCradden, PhD, MHSc
Director of AI in Medicine
The Hospital for Sick Children
On the Inextricability of Explainability from Ethics: Explainable AI does not Ethical AI Make

Explainability is embedded into a plethora of legal, professional, and regulatory guidelines as it is often presumed that an ethical use of AI will require explainable algorithms. There is considerable controversy, however, as to whether post hoc explanations are computationally reliable, their value for decision-making, and the relational implications of their use in shared decision-making. This talk will explore the literature across these domains and argue that while post hoc explainability may be a reasonable technical goal, it should not be offered status as a moral standard by which AI use is judged to be ‘ethical.’

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Livestream / Virtual Sat, 01 Oct 2022 17:10:43 -0400 2022-10-20T12:00:00-04:00 2022-10-20T13:30:00-04:00 Off Campus Location Department of Learning Health Sciences Livestream / Virtual LHS Collaboratory logo
OHS Seminar Series Schedule (October 20, 2022 12:00pm) https://events.umich.edu/event/98131 98131-21795619@events.umich.edu Event Begins: Thursday, October 20, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

OHS Seminar Series Schedule Fall 2022 - Stay tuned for more updates!

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Presentation Tue, 06 Sep 2022 13:16:28 -0400 2022-10-20T12:00:00-04:00 2022-10-20T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Presentation OHS Seminar Series Schedule Fall 2022
Rock, Paper, Scissors: The oral microbiome at the intersection of genotypic, anthropogenic and systemic factors (October 20, 2022 12:00pm) https://events.umich.edu/event/99963 99963-21798941@events.umich.edu Event Begins: Thursday, October 20, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

As a dual-trained periodontist and microbial ecologist, I use my clinical skills and training in ‘-omics’ research to investigate the myriad ways in which the human microbiome can be harnessed to promote health. I firmly believe that oral health and systemic diseases are intricately connected, and that global health can only be achieved when physicians and dentists collaborate to identify at-risk individuals and deliver integrated care.

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Lecture / Discussion Fri, 07 Oct 2022 10:59:44 -0400 2022-10-20T12:00:00-04:00 2022-10-20T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Lecture / Discussion Purnima Kumar, DDS, PhD
EEB Thursday Seminar - Hybrid: Using genetic data at multiple scales to understand constraints on viral adaptation (October 20, 2022 3:00pm) https://events.umich.edu/event/96696 96696-21793094@events.umich.edu Event Begins: Thursday, October 20, 2022 3:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Our weekly seminar series featuring internal and external speakers in the field of ecology and evolutionary biology. This seminar will be in-person and livestreaming on Zoom (link this page).

Abstract:
RNA viruses have exceptionally high mutation rates, on the order of one new mutation per replication cycle. These mutation rates are frequently invoked to explain the ability of these viruses to rapidly adapt to new or changing environmental conditions, such as changes in host immunity profiles for endemic viruses such as influenza and changes in host species in the case of spillover viruses. Here, I will instead focus on the evolutionary constraints to viral adaptation that are brought about by high mutation rates in the context of spatial within-host viral compartmentalization, transmission bottlenecks between infectors and infectees, and genetic linkage across viral genomes. I will also discuss means of population-level viral adaptation that are accessible in the context of these constraints. The empirical examples I will draw on will include influenza viruses and SARS-CoV-2.

Contact eebsemaccess@umich.edu for Zoom password at least 2 hours prior to event.

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Workshop / Seminar Fri, 14 Oct 2022 08:40:04 -0400 2022-10-20T15:00:00-04:00 2022-10-20T16:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Research image from lab.
MCDB Seminar> Illuminating zinc in axonal transport and tau/MAP2/DCX displacement (October 21, 2022 12:00pm) https://events.umich.edu/event/98606 98606-21796963@events.umich.edu Event Begins: Friday, October 21, 2022 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Wanlu Du

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Workshop / Seminar Fri, 30 Sep 2022 13:19:35 -0400 2022-10-21T12:00:00-04:00 2022-10-21T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar drawing of axon and biochemistry of zinc transport
2022 Environmental Statistics Day [Keynote, Panel Discussion & Lightning Talks] (October 24, 2022 9:45am) https://events.umich.edu/event/99876 99876-21798821@events.umich.edu Event Begins: Monday, October 24, 2022 9:45am
Location: School of Public Health Bldg I and Crossroads and Tower
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

On Monday, October 24 please join us (in-person or on Zoom) for the 2022 Environmental Statistics Day. Keynote speaker is Corwin Zigler, PhD (Assoc. Professor, Dept. of Statistics & Data Sciences, Univ of TX, Austin). Dr. Zigler will present **Causal Inference in Air Quality Regulation: an Overview and Topics in Statistical Methodology**. A Panel Discussion follows the keynote with Dr. Zigler and School of Public Health faculty Roderick Little (Biostats), Tim Dvonch (EHS) and Sara Adar (Epid). The event concludes with lunch and Lightning Talks by current Biostats students and postdocs.

Registration required
In-person https://forms.gle/rgRZS1aFGdG4dAog9
Virtual on Zoom https://umich.zoom.us/webinar/register/WN_oEcKXLxBSCSxTgI3_4G4Zg#/registration

Schedule
9:45-10:00 am | Arrival & Refreshments (1680 SPH I)
10:00-10:50 am | Keynote (1680 SPH I + Zoom)
10:50-11:30 am | Panel Discussion (1680 SPH I + Zoom)
11:30-11:40 am | Break
11:40 am-1:00 pm | Lunch & Student/Postdoc Lightning Talks (1680 SPH I + Zoom)

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Conference / Symposium Thu, 20 Oct 2022 13:31:57 -0400 2022-10-24T09:45:00-04:00 2022-10-24T13:00:00-04:00 School of Public Health Bldg I and Crossroads and Tower Michigan Lifestage Environmental Exposures and Disease Center Conference / Symposium Oct 24 Environmental Statistics Day (Keynote - Corwin Zigler, Univ of TX)
Understanding the Bud Tip Progenitor Cell Niche During Human Lung Development (October 24, 2022 1:00pm) https://events.umich.edu/event/99280 99280-21797806@events.umich.edu Event Begins: Monday, October 24, 2022 1:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

Dissertation Defense

We are pleased to announce that Renee Hein, Ph.D. Candidate, will present her Dissertation Defense titled "Understanding the Bud Tip Progenitor Cell Niche During Human Lung Development" on Monday, October 24, 2022 from 1-2:00 p.m., via live stream: Livestream: https://umich.zoom.us/j/98731748905, Passcode: CDB, and in Person at BSRB Kahn Auditorium.

Dissertation Committee
Idse Heemskerk (Chair)
Jason Spence (Mentor)
Rachel Zemans
Kurt Hankenson
Joshua Welch

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Lecture / Discussion Mon, 26 Sep 2022 08:43:17 -0400 2022-10-24T13:00:00-04:00 2022-10-24T14:00:00-04:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion Understanding the Bud Tip Progenitor Cell Niche During Human Lung Development,
Synthetic and Catalytic Applications of Halogen Bond (October 25, 2022 11:30am) https://events.umich.edu/event/95564 95564-21790157@events.umich.edu Event Begins: Tuesday, October 25, 2022 11:30am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Organic
Wei Li (University of Toledo)

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Other Tue, 25 Oct 2022 18:15:40 -0400 2022-10-25T11:30:00-04:00 2022-10-25T12:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Advanced methods in cryogenic correlative light and electron microscopy: from super-resolution to fluorescent biosensors- Department of Biological Chemistry Seminar Series (October 25, 2022 12:00pm) https://events.umich.edu/event/99070 99070-21797523@events.umich.edu Event Begins: Tuesday, October 25, 2022 12:00pm
Location: Medical Science Unit I
Organized By: Biological Chemistry

Dr. Peter Dahlberg will present the Department of Biological Chemistry Seminar on Tuesday October 25th at 12:00pm.

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Workshop / Seminar Tue, 20 Sep 2022 08:35:58 -0400 2022-10-25T12:00:00-04:00 2022-10-25T13:00:00-04:00 Medical Science Unit I Biological Chemistry Workshop / Seminar
EEB Tuesday Lunch Seminar - Hybrid: Recombination and the evolution of sex chromosomes in Rumex hastatulus (October 25, 2022 12:00pm) https://events.umich.edu/event/97019 97019-21793697@events.umich.edu Event Begins: Tuesday, October 25, 2022 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Our weekly lunch seminar series featuring internal speakers in the field of ecology and evolutionary biology.

Abstract
Sex chromosomes typically evolve through the gradual reduction of recombination between chromosome pairs that have acquired a sex-determining region. Many plants have "younger" sex chromosomes than amniotes, and therefore offer valuable insight into this process. Heartwing sorrel (Rumex hastatulus) has a polymorphic sex chromosome karyotype resulting from a chromosome fusion. This natural variation allows direct comparison of a sex chromosome and its autosomal homologue. We use a recent genome assembly and genetic map to explore how recombination evolved in this species and how that challenges standard models of sex chromosome evolution.

This seminar will be in-person and livestreaming on Zoom (link this page). Contact eebsemaccess@umich.edu for password at least two hours prior to the event.

Image credit: Spencer Barrett

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Workshop / Seminar Wed, 19 Oct 2022 13:24:29 -0400 2022-10-25T12:00:00-04:00 2022-10-25T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Rumex hastaulus size dimorphism by Spencer Barrett
Functional MRI Speaker Series (October 25, 2022 4:00pm) https://events.umich.edu/event/99181 99181-21797673@events.umich.edu Event Begins: Tuesday, October 25, 2022 4:00pm
Location: East Hall
Organized By: Functional MRI Lab

Title: Protracted Development of Association Cortex in Youth

Abstract: During childhood and adolescence, cortical development progresses from lower-order unimodal cortices to higher-order association cortices. Here we will review recent work from large-scale neuroimaging studies that illustrate how this protracted developmental program endows the brain’s association cortices with unique functional properties to support executive function, but also leaves humans at risk for diverse psychopathologies.







*There will be light refreshments.

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Lecture / Discussion Thu, 13 Oct 2022 11:37:15 -0400 2022-10-25T16:00:00-04:00 2022-10-25T17:30:00-04:00 East Hall Functional MRI Lab Lecture / Discussion Theodore D. Satterthwaite, MD
Futures in Research, Science, and Teaching - General meeting (October 25, 2022 4:00pm) https://events.umich.edu/event/96044 96044-21791849@events.umich.edu Event Begins: Tuesday, October 25, 2022 4:00pm
Location:
Organized By: Futures in Research, Science, Teaching - FIRST

General meetings take place every other Tuesday from September 13 to December 6th. Events include:

September 13th: Pathways in Research (Graduate student/Faculty panel)
September 27th: Mixer (food provided)
October 11th: Poster design and presentation
October 25th: Applying to graduate school - application components and essay writing advice
November 8th: Finding paid summer and post-baccalaureate research opportunities
November 22nd: Faculty talk
December 6th: Mixer

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Meeting Mon, 12 Sep 2022 12:26:57 -0400 2022-10-25T16:00:00-04:00 2022-10-25T17:00:00-04:00 Futures in Research, Science, Teaching - FIRST Meeting Event flyer detailing date, time, and location: September 13th at 4 pm, BSB 1010
Writing Personal and Academic Statements (October 25, 2022 4:00pm) https://events.umich.edu/event/100505 100505-21800018@events.umich.edu Event Begins: Tuesday, October 25, 2022 4:00pm
Location: Biological Sciences Building
Organized By: Futures in Research, Science, Teaching - FIRST

Bioscience postdocs and grad students will give a presentation on what to include/avoid and how to frame your story while writing academic and personal statements for research-based grad programs (and others). There will be a chance after for anyone interested in workshopping their statement drafts in small groups.

RSVP: https://forms.gle/43KP9utUYjCknofm8

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Workshop / Seminar Thu, 20 Oct 2022 12:54:49 -0400 2022-10-25T16:00:00-04:00 2022-10-25T17:30:00-04:00 Biological Sciences Building Futures in Research, Science, Teaching - FIRST Workshop / Seminar FIRST Logo
Protease-activated Receptor Signaling and Endothelial Function (October 26, 2022 9:30am) https://events.umich.edu/event/98294 98294-21796455@events.umich.edu Event Begins: Wednesday, October 26, 2022 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

CDB Seminar Series

We are pleased to announce that JoAnne Trejo, Ph.D., M.B.A. will present her talk titled, "Protease-activated Receptor Signaling and Endothelial Function", on Wednesday, 10/26/22 from 9:30-10:30 a.m. in BSRB – ABC Conference rooms, and via live stream: Meeting Link: https://umich.zoom.us/s/93126459104

Hosted By:
CDB Students

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Lecture / Discussion Thu, 29 Sep 2022 16:38:49 -0400 2022-10-26T09:30:00-04:00 2022-10-26T10:30:00-04:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion Protease-activated Receptor Signaling and Endothelial Function
Graduate Studies in Computational & Data Sciences Information Session (October 26, 2022 1:30pm) https://events.umich.edu/event/100680 100680-21800224@events.umich.edu Event Begins: Wednesday, October 26, 2022 1:30pm
Location: Lurie Robert H. Engin. Ctr
Organized By: Michigan Institute for Computational Discovery and Engineering

The educational programs represented are:
- PhD in Scientific Computing (MICDE)
- Graduate Certificate in Computational Discovery & Engineering (MICDE)
- Graduate Certificate in Computational Neuroscience (MICDE)
- Graduate Certificate in Data Science (MIDAS)

These programs are open to all U-M graduate students with an interest in scientific computing or data science. These methodologies can have a wide range of applications - current and past students have come from a variety of home departments including Aerospace Engineering, Applied Physics, Biostatistics, Biomedical Engineering, Civil & Environmental Engineering, Chemistry, Chemical Engineering, Climate and Space Sciences and Engineering, Computational Medicine and Bioinformatics, Ecology and Evolutionary Biology, Earth and Environmental Sciences, Epidemiology, Health Behavior and Health Education, Health Infrastructures & Learning Systems, Information, Industrial & Operations Engineering, Kinesiology, Linguistics, Macromolecular Science & Engineering, Math, Molecular, Cellular, and Developmental Biology, Mechanical Engineering, Materials Science & Engineering, Naval Architecture & Marine Engineering, Nuclear Engineering & Radiological Sciences, Neuroscience, Pharmaceutical Sciences, Physics, Political Science, Psychology, Environment and Sustainability, Sociology and Statistics.

If you have any questions about these programs or about the information session, please reach out to MICDE (micde-contact@umich.edu) or MIDAS (midas-contact@umich.edu).

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Presentation Tue, 25 Oct 2022 13:46:55 -0400 2022-10-26T13:30:00-04:00 2022-10-26T14:30:00-04:00 Lurie Robert H. Engin. Ctr Michigan Institute for Computational Discovery and Engineering Presentation MICDE/MIDAS Information Session - PhD in Scientific Computing (MICDE) - Graduate Certificate in Computational Discovery & Engineering (MICDE) - Graduate Certificate in Computational Neuroscience (MICDE) - Graduate Certificate in Data Science (MIDAS)