Happening @ Michigan https://events.umich.edu/list/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. CSIEUM - Workshop: Big Data in Pharma - Brainstorming a new 1-credit class (August 30, 2019 12:00pm) https://events.umich.edu/event/65519 65519-16607704@events.umich.edu Event Begins: Friday, August 30, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Marc Scanio (Abbvie)

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Other Fri, 30 Aug 2019 18:15:31 -0400 2019-08-30T12:00:00-04:00 2019-08-30T13:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
DEADLINE FAST APPROACHING: BSI Exploratory Funding Grants (August 30, 2019 5:00pm) https://events.umich.edu/event/65603 65603-16621810@events.umich.edu Event Begins: Friday, August 30, 2019 5:00pm
Location:
Organized By: Biosciences Initiative

Biosciences Initiative (BSI) exploratory funding grants focus on early stage research activities. Examples include:
• workshops exploring new scientific fields of research
• sabbatical funding for external experts
• developing unique research resources benefitting multiple investigators
• developing partnerships between U-M and other organizations

To read more about the exploratory funding opportunities and to submit a proposal, please click here: https://biosciences.umich.edu/funding-opportunities/rfa/

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Other Thu, 22 Aug 2019 16:09:36 -0400 2019-08-30T17:00:00-04:00 2019-08-30T17:00:00-04:00 Biosciences Initiative Other Funding Opportunity
EEB Tuesday Lunch Seminar: Studying speciation in terrestrial gastropods: integrating genomic, ecological, and morphological data (September 3, 2019 12:00pm) https://events.umich.edu/event/65222 65222-16555450@events.umich.edu Event Begins: Tuesday, September 3, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Speciation is of fundamental interest to evolutionary biologists, and is driven by a complex interplay of factors. By integrating genomic, ecological, and morphological data, we can begin to disentangle the process of speciation. The Pacific Northwest of North America has a rich history of phylogeographic research, and temperate rainforest endemics from the region have been influenced by a diverse array of factors, including climatic and geologic events. By studying groups from this region in a comparative context, we identify ecological and morphological traits influencing species responses to these events. Further, by studying speciation and species limits in an integrative context, we can begin to understand how these and other factors have contributed to speciation. We focus on terrestrial taildropper slugs (Genus Prophysaon), and infer a history of divergence followed by secondary contact, with ecological data suggesting that reinforcement may have driven speciation. By integrating across datatypes and considering the processes that drive speciation, we infer biologically meaningful species limits and learn about which factors led to speciation.

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Workshop / Seminar Tue, 03 Sep 2019 13:03:54 -0400 2019-09-03T12:00:00-04:00 2019-09-03T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar A brown slug on a green leaf, its body curved into an S shape
Increasing Molecular Coverage in Complex Biological & Environmental Samples Using Ion Mobility-Mass Spectrometry (September 5, 2019 4:00pm) https://events.umich.edu/event/64170 64170-16179703@events.umich.edu Event Begins: Thursday, September 5, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


Mass spectrometry (MS)-based technologies are playing a growing role in the analysis of complex samples. Despite significant advances in MS technology, currently it is difficult to obtain measurements of both high throughput and high sensitivity for samples with great dynamic ranges such as biofluids and plant extracts. This problem ultimately results in the inability to effectively account for variation among sample conditions and/or biodiversity leading to inconsequential findings for samples which have great variation. To address this challenge, we have coupled an ion mobility separation (IMS) with MS to afford greatly improved measurement throughput, sensitivity, robustness, and quantitative capabilities for rapid analysis of complex samples. The benefits we have observed in omic studies of biological and environmental samples with IMS-MS will be summarized in this presentation.





Erin Baker (NC State)

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Other Thu, 05 Sep 2019 18:15:31 -0400 2019-09-05T16:00:00-04:00 2019-09-05T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Ideas Lab Participant Applications Due (September 5, 2019 5:00pm) https://events.umich.edu/event/65582 65582-16619780@events.umich.edu Event Begins: Thursday, September 5, 2019 5:00pm
Location:
Organized By: Biosciences Initiative

To learn more about the Ideas Lab and to Apply, please click on this link:
https://biosciences.umich.edu/funding-opportunities/ideas-lab/2019-10/

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Other Fri, 23 Aug 2019 11:25:50 -0400 2019-09-05T17:00:00-04:00 2019-09-05T17:00:00-04:00 Biosciences Initiative Other Ideas Lab Banner
UM Structure Seminar: Beyond the Resolution Revolution: Mining Ribosome Assembly Heterogeneity in Single Particle Cryo-EM (September 6, 2019 10:00am) https://events.umich.edu/event/65034 65034-16507305@events.umich.edu Event Begins: Friday, September 6, 2019 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

https://williamson.scripps.edu/personnel/jessica/

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Lecture / Discussion Thu, 08 Aug 2019 10:52:55 -0400 2019-09-06T10:00:00-04:00 2019-09-06T11:00:00-04:00 Life Sciences Institute U-M Structural Biology Lecture / Discussion Life Sciences Institute
Biophysics Talk Title: TBD (September 6, 2019 12:00pm) https://events.umich.edu/event/64280 64280-16274491@events.umich.edu Event Begins: Friday, September 6, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstracts: TBD

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Workshop / Seminar Wed, 10 Jul 2019 11:26:22 -0400 2019-09-06T12:00:00-04:00 2019-09-06T13:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
RNA innovation Seminar (September 9, 2019 4:00pm) https://events.umich.edu/event/65134 65134-16539445@events.umich.edu Event Begins: Monday, September 9, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Abstract: RNA regulation permeates neurobiology. Nociceptors are sensory neurons tasked with the detection of pain producing stimuli. Persistent changes in their activity, termed plasticity, benefit survival through injury avoidance. Nociceptors rely on cap-dependent translation to rapidly increase protein synthesis in response to pro-inflammatory signals. Comparatively little is known regarding the role of the regulatory factors bound to the 3' end of mRNA in nociceptor sensitization. Poly(A)-binding protein (PABP) stimulates translation initiation by bridging the Poly(A) tail to the eukaryotic initiation factor 4F complex associated with the mRNA cap. We have developed an RNA-based competitive inhibitor of PABP that attenuates behavioral responses to pain in mice. To identify the Poly(A) mRNAs subject to privileged translation in response to noxious cues, we have applied ribosome profiling to primary sensory neurons and tissues. A small number of transcripts are selectively translated in response to plasticity mediators. Among them is the capsid forming protein Arc. Arc has been implicated in synaptic plasticity and learning in the brain. We demonstrate that the ribosomal S6 kinase 1 is responsible for Arc production in nociceptors and describe a new role for local translation of Arc in afferent fibers. Collectively, our findings uncover mechanisms and targets of RNA control in sensory neurons that can be exploited to disrupt pain signaling.

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Lecture / Discussion Tue, 20 Aug 2019 15:48:42 -0400 2019-09-09T16:00:00-04:00 2019-09-09T17:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion flyer
Department of Biological Chemistry Seminar Series (September 10, 2019 12:00pm) https://events.umich.edu/event/65270 65270-16563481@events.umich.edu Event Begins: Tuesday, September 10, 2019 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Robert Spitale, UCI, will be giving a seminar for the Department of Biological Chemistry on 09/10/19. The seminar titled "Biochemical Approaches to Analyzing the Transcriptome" will be presented at 12:00 noon in North Lecture Hall, Medical Science Building II

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Workshop / Seminar Mon, 09 Sep 2019 14:10:07 -0400 2019-09-10T12:00:00-04:00 2019-09-10T13:00:00-04:00 Medical Science Unit II Biological Chemistry Workshop / Seminar Robert Spitale, Ph.D.- University of California, Irvine
EEB Tuesday Lunch Seminar: Towards a molecular model of monarch migration (September 10, 2019 12:00pm) https://events.umich.edu/event/64992 64992-16499301@events.umich.edu Event Begins: Tuesday, September 10, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Join us for our weekly brown bag lunch seminar.

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Workshop / Seminar Mon, 09 Sep 2019 12:20:54 -0400 2019-09-10T12:00:00-04:00 2019-09-10T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Monarch butterfly on a leaf
Environmental Research Seminar "Health & Household-Related Benefits of Weatherizing Low-Income Homes & Affordable Multifamily Buildings" (September 10, 2019 12:00pm) https://events.umich.edu/event/65290 65290-16565509@events.umich.edu Event Begins: Tuesday, September 10, 2019 12:00pm
Location: Public Health I (Vaughan Building)
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

The federal government, states, and utilities administer programs to improve the energy efficiency of low-income homes and affordable multifamily buildings. Investments in measures to save energy, as simple as air sealing and insulation, can also yield a broad range of non-energy benefits. This presentation will present research results that show that weatherization can improve health, home conditions, and social determinants of health. The results are drawn from three separate studies that were conducted nationally, regionally (Midwest and Northeast), and in Knoxville, Tennessee. Three3, Inc. conducts research and educational programming to promote the integration of environmental, social, and economic sustainability. The organization particularly focuses on fostering sustainable futures that: provide equitable benefits to low-income and disadvantaged populations (intra-generational equity); meets ethical obligations to future generations (inter-generational equity); and makes best use of the convergence of human knowledge and technology to meet sustainability goals.

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Workshop / Seminar Thu, 15 Aug 2019 15:56:22 -0400 2019-09-10T12:00:00-04:00 2019-09-10T13:00:00-04:00 Public Health I (Vaughan Building) Michigan Lifestage Environmental Exposures and Disease Center Workshop / Seminar 09/10/2019 Bruce Tonn "Health & Household-Related Benefits of Weatherizing Low-Income Homes & Affordable Multifamily Buildings"
From fluctuations to function: The role of dynamics in the mechanism and regulation of translation (September 10, 2019 4:00pm) https://events.umich.edu/event/63255 63255-15603733@events.umich.edu Event Begins: Tuesday, September 10, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Over the past two decades, stunning breakthroughs in the field of structural biology have continued to produce groundbreaking high-resolution structures of large, multi-component biomolecular machines. Comparative analyses of these static structures reveals the remarkable conformational flexibility of these machines and hints at the significant structural rearrangements that evidently accompany their functional cycles. Unfortunately, the experimental observation and characterization of these conformational dynamics is severely impeded by the size and complexity of biomolecular machines, severely limiting our understanding of the contributions that dynamics make to their functions. Using a combination of single-molecule biophysical-, structural-, and biochemical approaches, my research group aims to overcome these challenges and elucidate the precise roles that the conformational dynamics of biomolecular machines play in driving and controlling their functions. My seminar presentation will primarily focus on our studies of the mechanism and regulation of messenger RNA translation into protein by the ribosome, an essential step in gene expression. Specifically, I will discuss how thermally driven fluctuations of the ribosome and other essential translation components contribute to the mechanism and regulation of translation. Because the ribosome is the target of over half of all currently prescribed antibiotics and because of the growing list of human diseases to which deregulation of translation has been causally linked, our findings hold great promise for informing the development of next-generation antibiotics and small-molecule therapeutic agents that function by modulating the conformational dynamics of the translation machinery. Building on what we have learned from these studies, I will close my presentation by describing recent technological advances that are allowing us to investigate biomolecular dynamics which play important roles in biological mechanisms, but that have thus far remained difficult or impossible to investigate.




Ruben Gonzalez (Columbia University)

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Other Tue, 10 Sep 2019 18:15:37 -0400 2019-09-10T16:00:00-04:00 2019-09-10T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Stem Cell Development: Stories of Two Niches. (September 10, 2019 4:00pm) https://events.umich.edu/event/65613 65613-16621819@events.umich.edu Event Begins: Tuesday, September 10, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for Cell Plasticity and Organ Design

2019-2020 Center for Organogenesis Seminar Series

Faculty Host: Peter Ma
For additional information contact: organogenesis@umich.edu

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Lecture / Discussion Thu, 22 Aug 2019 14:20:45 -0400 2019-09-10T16:00:00-04:00 2019-09-10T17:00:00-04:00 Taubman Biomedical Science Research Building Center for Cell Plasticity and Organ Design Lecture / Discussion Stem Cell Development: Stories of Two Niches.
DCMB Seminar - Neurons in pathology through the lens of multi-omics and data analytics (September 11, 2019 4:00pm) https://events.umich.edu/event/65485 65485-16605630@events.umich.edu Event Begins: Wednesday, September 11, 2019 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract:

Advances in stem cell engineering, omics technologies and data sciences offer a unique scope for deciphering the myriad ways molecular circuits dysfunction in pathologies of the brain. Recently, we have developed and explored iPSC-derived neurons from familial Alzheimer’s disease patients using a systems-level, multi-omics approach, identifying disease-related endotypes, which are commonly dysregulated in patient-derived neurons and patient brain tissue alike. By integrating RNA-Seq, ATAC-Seq, and ChIP-Seq approaches, we determined that the defining disease-causing mechanism of AD is de-differentiation of neurons, driven primarily through the REST-mediated repression of neuronal lineage specification gene programs and the activation of cell cycle reentry and non-specific germ layer precursor gene programs concomitant with modifications in chromatin accessibility. Strikingly, our reanalysis of previously-generated AD-patient brain tissue showed similar enrichment of neuronal repression and de-differentiation mechanisms. Surprisingly, our earlier work on glioblastoma also showed de-differentiation and initiation of some of the shared diseased endotypes as common features. We postulate that de-differentiation and reprogramming are hallmark mechanisms of numerous pathologies, arguably genetically evolved to serve as protection mechanisms.

Acknowledgements: This work was done in collaboration with the Laboratory of Dr. Wagner and his colleagues.

References:
Caldwell AB, Liu Q, Schroth GP, Tanzi RE, Galasko DR, Yuan SH, Wagner SL, Subramaniam S. Dedifferentiation orchestrated through remodeling of the chromatin landscape defines PSEN1 mutation-induced Alzheimer's Disease. 2019 (under revision in Nature) Available from: https://www.biorxiv.org/content/10.1101/531202v1.
Friedmann-Morvinski D, Bhargava V, Gupta S, Verma IM, Subramaniam S. Identification of therapeutic targets for glioblastoma by network analysis. Oncogene. 2016;35(5):608-20. PMCID: 4641815.
Bhargava V, Ko P, Willems E, Mercola M, Subramaniam S. Quantitative transcriptomics using designed primer-based amplification. Sci Rep. 2013;3:1740. PMCID: 3638165.

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Lecture / Discussion Tue, 20 Aug 2019 13:49:51 -0400 2019-09-11T16:00:00-04:00 2019-09-11T17:00:00-04:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
EEB Thursday Seminar: Robots, telemetry, and the sex lives of wild birds: Using technology to study courtship and conservation (September 12, 2019 4:00pm) https://events.umich.edu/event/65039 65039-16507309@events.umich.edu Event Begins: Thursday, September 12, 2019 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Males in many species must convince females to mate by producing elaborate courtship displays tuned to female preferences, like the song of a cricket or the train of a peacock. But courtship in many species is more like a negotiation than an advertisement, thus in addition to elaborate signals, success in courtship may require tactical skills. These skills may include the ability to choose a flattering display site, respond appropriately to female courtship signals, and adjust display investment in response to the marketplace of other males and females. My lab has been investigating courtship negotiations in greater sage-grouse, which mate in an open marketplace of competing males and choosing females (the lek). I will discuss experiments using robotic females to investigate courtship interactions between the sexes. I will also discuss ongoing research investigating how off-lek foraging behaviors affect on-lek displays, and how this basic science has informed my lab's research into human impacts on lekking activities.

View YouTube video of seminar: https://youtu.be/6uyRvNb_vGg

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Workshop / Seminar Fri, 20 Sep 2019 11:15:46 -0400 2019-09-12T16:00:00-04:00 2019-09-12T17:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Seminar photo
Pushing the Limits: Mass Spectrometry of Arctic Atmospheric Chemistry (September 12, 2019 4:00pm) https://events.umich.edu/event/64128 64128-16165588@events.umich.edu Event Begins: Thursday, September 12, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Kerri Pratt (University of Michigan)

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Other Thu, 12 Sep 2019 18:15:35 -0400 2019-09-12T16:00:00-04:00 2019-09-12T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Robotics Interfaces with Biology (September 12, 2019 4:00pm) https://events.umich.edu/event/65462 65462-16603589@events.umich.edu Event Begins: Thursday, September 12, 2019 4:00pm
Location: Biological Sciences Building
Organized By: Michigan Robotics

Gail Patricelli, Professor & Chancellor’s Fellow, Department of Evolution and Ecology, UC Davis presents her work on using robotics to study courtship behavior in birds.

Males in many species must convince females to mate by producing elaborate courtship displays tuned to female preferences, like the song of a cricket or the train of a peacock. But courtship in many species is more like a negotiation than an advertisement, thus in addition to elaborate signals, success in courtship may require tactical skills. These skills may include the ability to choose a flattering display site, respond appropriately to female courtship signals, and adjust display investment in response to the marketplace of other males and females. My lab has been investigating courtship negotiations in greater sage-grouse, which mate in an open marketplace of competing males and choosing females (the lek). I will discuss experiments using robotic females to investigate courtship interactions between the sexes. I will also discuss ongoing research investigating how off-lek foraging behaviors affect on-lek displays, and how this basic science has informed my lab's research into human impacts on lekking activities.

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Workshop / Seminar Tue, 20 Aug 2019 09:15:09 -0400 2019-09-12T16:00:00-04:00 2019-09-12T17:00:00-04:00 Biological Sciences Building Michigan Robotics Workshop / Seminar Sage grouse photo by Gail Patricelli
Biophysics Krimm Lecture - Talk Title: Shining light onto the dark matter of biology: Ion flux modulation and the perplexing resilience of bacteria (September 13, 2019 12:00pm) https://events.umich.edu/event/64266 64266-16274470@events.umich.edu Event Begins: Friday, September 13, 2019 12:00pm
Location: Rackham Graduate School (Horace H.)
Organized By: LSA Biophysics

Abstract: TBD

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Workshop / Seminar Wed, 04 Sep 2019 14:42:01 -0400 2019-09-13T12:00:00-04:00 2019-09-13T13:30:00-04:00 Rackham Graduate School (Horace H.) LSA Biophysics Workshop / Seminar Rackham Graduate School (Horace H.)
MCDB Seminar: Estrogen Regulation of Gene Expression in the Brain (September 13, 2019 12:00pm) https://events.umich.edu/event/64084 64084-16115268@events.umich.edu Event Begins: Friday, September 13, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Josie Clowney

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Workshop / Seminar Tue, 10 Sep 2019 12:38:29 -0400 2019-09-13T12:00:00-04:00 2019-09-13T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar micrograph of brain, stained green with chart of estrogen measurement and others
Precision Health Analytics Platform Roadshow (September 13, 2019 2:00pm) https://events.umich.edu/event/66947 66947-16787735@events.umich.edu Event Begins: Friday, September 13, 2019 2:00pm
Location: North Campus Research Complex Building 10
Organized By: Precision Health

Are you a health researcher looking for genetic and clinical data, or do you need assistance in data analysis?

Precision Health’s new Analytics Platform is a suite of tools, services, and datasets available to researchers across campus--resources previously available only to Michigan Medicine faculty and other level-two password holders. The platform provides campus-wide access to research tools such as DataDirect and services such as consultation with scientific facilitators.

Attend a roadshow to learn how to access the platform and what you can do with it:

• Perform cohort discovery on a database of 4M+ patients
• Query a de-identified, structured dataset of ~60K patients
• Submit queries through the self-serve tool DataDirect
• Access output via a secure, HIPAA-compliant environment
• Request access to linked genetic data (with IRB approval)

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Presentation Wed, 11 Sep 2019 14:58:31 -0400 2019-09-13T14:00:00-04:00 2019-09-13T15:30:00-04:00 North Campus Research Complex Building 10 Precision Health Presentation PH DataDirect
Design principles for organization and self-assembly far from equilibrium (September 17, 2019 11:30am) https://events.umich.edu/event/66305 66305-16727932@events.umich.edu Event Begins: Tuesday, September 17, 2019 11:30am
Location: Weiser Hall
Organized By: The Center for the Study of Complex Systems

Non-equilibrium thermodynamics provides a useful set of tools to analyze and constrain the behavior of far from equilibrium systems. However, these tools have not yet been broadly applied to aid in the control of many body systems and materials assembled far from equilibrium. In this talk, I will report an application of ideas from non-equilibrium thermodynamics to the problems related to morphological changes in membranes, non-equilibrium self-assembly and more broadly control of material properties far from equilibrium. In many of these contexts, I will show how the material properties can be substantially constrained (and even predicted) using tools from non-equilibrium thermodynamics.

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Workshop / Seminar Mon, 09 Sep 2019 10:34:54 -0400 2019-09-17T11:30:00-04:00 2019-09-17T13:00:00-04:00 Weiser Hall The Center for the Study of Complex Systems Workshop / Seminar S. Vaikuntanathan
Department of Biological Chemistry Seminar Series (September 17, 2019 12:00pm) https://events.umich.edu/event/66167 66167-16717498@events.umich.edu Event Begins: Tuesday, September 17, 2019 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Richard Gardner will present a seminar for the Department of Biological Chemistry on Tuesday September 17th, 2019 at 12:00 noon in North Lecture Hall, MS II. The seminar is titled: "Nuclear Armageddon...How the Cell Averts Devastation from Nuclear Protein Aggregation."

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Lecture / Discussion Mon, 09 Sep 2019 14:12:04 -0400 2019-09-17T12:00:00-04:00 2019-09-17T13:00:00-04:00 Medical Science Unit II Biological Chemistry Lecture / Discussion
EEB Tuesday Lunch Seminar: Complex forms of spatial patterning: self-organization from ecological complexity (September 17, 2019 12:00pm) https://events.umich.edu/event/64995 64995-16501294@events.umich.edu Event Begins: Tuesday, September 17, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Please join us at our weekly EEB brown bag lunch seminar.

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Workshop / Seminar Tue, 10 Sep 2019 11:20:02 -0400 2019-09-17T12:00:00-04:00 2019-09-17T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Extinction graph with images showing various members of the ecological community he studies. Text on graph includes: bifurcation and chaos zone, basin boundary collision, hysteresis zones, saddle/node bifurcation and extinction graph shows upward trend
Boron Cluster Building Blocks and Synthetic Reagents (September 17, 2019 4:00pm) https://events.umich.edu/event/65046 65046-16509306@events.umich.edu Event Begins: Tuesday, September 17, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry



TBD




Alexander Spokoyny (UCLA)

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Other Tue, 17 Sep 2019 18:15:51 -0400 2019-09-17T16:00:00-04:00 2019-09-17T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Gene modified and edited cell based therapies for cancer: Are we there yet? (September 17, 2019 4:00pm) https://events.umich.edu/event/65612 65612-16621814@events.umich.edu Event Begins: Tuesday, September 17, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for Cell Plasticity and Organ Design

2019-2020 Centr for Organogenesis Seminar Series.

Faculty Host: Xing Fan

For additional information contact: organogenesis@umich.edu

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Lecture / Discussion Thu, 22 Aug 2019 14:11:42 -0400 2019-09-17T16:00:00-04:00 2019-09-17T17:00:00-04:00 Taubman Biomedical Science Research Building Center for Cell Plasticity and Organ Design Lecture / Discussion Gene modified and edited cell based therapies for cancer: Are we there yet?
Human Genetics Seminar Series - RNA aggregation and neurodegenerative disease (September 17, 2019 4:00pm) https://events.umich.edu/event/67326 67326-16837723@events.umich.edu Event Begins: Tuesday, September 17, 2019 4:00pm
Location: Buhl Res Cen for Human Genetics
Organized By: Human Genetics

Tuesday, September 17, 2019
4:00‐5:00 PM
5915 Buhl Classroom
Hosted by: Stephanie Bielas

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Other Tue, 17 Sep 2019 13:47:15 -0400 2019-09-17T16:00:00-04:00 2019-09-17T17:00:00-04:00 Buhl Res Cen for Human Genetics Human Genetics Other
Reconstituting Eukaryotic Cytokinesis (September 17, 2019 4:00pm) https://events.umich.edu/event/65873 65873-16662157@events.umich.edu Event Begins: Tuesday, September 17, 2019 4:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Hosts: Allen Liu (Mechanical Engineering), Ann Miller (MCDB), and Puck Ohi (CDB)

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Workshop / Seminar Tue, 27 Aug 2019 16:40:41 -0400 2019-09-17T16:00:00-04:00 2019-09-17T17:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar pombe cytokinesis
FocusCEE Info Session (September 17, 2019 6:00pm) https://events.umich.edu/event/65414 65414-16595554@events.umich.edu Event Begins: Tuesday, September 17, 2019 6:00pm
Location: GG Brown Laboratory
Organized By: Civil and Environmental Engineering

Civil and Environmental Engineering (CEE) is a growing engineering field that looks at society, cities, the environment, and technology.

This year, we're also launching FocusCEE, a new program that allows you to focus your engineering education in CEE by tailoring your curriculum to a particular theme. Each focus area combines a major in CEE with additional courses that often meet the requirements for a specific LSA minor.

Stop by our info session to learn more! The whole thing will be super casual, fun and we’ll have food and drinks.

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Reception / Open House Mon, 19 Aug 2019 11:31:44 -0400 2019-09-17T18:00:00-04:00 2019-09-17T20:00:00-04:00 GG Brown Laboratory Civil and Environmental Engineering Reception / Open House FocusCEE areas: Community Policy and Planning, Smart Cities, Sustainability
Violation of Mendel’s First Law: chromosome competition in meiosis (September 18, 2019 9:30am) https://events.umich.edu/event/65374 65374-16573573@events.umich.edu Event Begins: Wednesday, September 18, 2019 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

2019 Cell & Developmental Biology Seminar Series

Hosted By: Ajit Joglekar, PhD and Yukiko Yamashita, PhD

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Lecture / Discussion Fri, 16 Aug 2019 16:44:53 -0400 2019-09-18T09:30:00-04:00 2019-09-18T10:30:00-04:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion Michael Lampson
Make It Stick: Research-Based Learning Strategies You Need to Know (September 18, 2019 5:30pm) https://events.umich.edu/event/65980 65980-16678383@events.umich.edu Event Begins: Wednesday, September 18, 2019 5:30pm
Location: Angell Hall
Organized By: Science Learning Center

The study and learning strategies students often bring to college are often insufficient to help them succeed at the university level. Particularly in challenging STEM courses, students can't simply memorize or cram their way to a good grade. This workshop will focus on the popular learning strategies to avoid, as well as the top three strategies you don't know but are shown by research to be the most effective for long-term learning.

Registration Link: http://ttc.iss.lsa.umich.edu/undergrad/sessions/make-it-stick-research-based-learning-strategies-you-need-to-know-science-success-series/

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Workshop / Seminar Wed, 04 Sep 2019 15:39:54 -0400 2019-09-18T17:30:00-04:00 2019-09-18T19:00:00-04:00 Angell Hall Science Learning Center Workshop / Seminar
EEB Thursday Seminar: Charting the spatiotemporal landscape of species’ responses to climate change (September 19, 2019 4:00pm) https://events.umich.edu/event/65040 65040-16507310@events.umich.edu Event Begins: Thursday, September 19, 2019 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

The Carolina Parakeet, the Heath Hen, the Passenger Pigeon—when we contemplate how bird diversity has changed, we often focus on the handful of species we have lost entirely. But while we have yet to lose a single bird species to our rapidly changing climate, birds and other creatures are currently adapting and responding. Studying changing bird communities over decades to centuries, Dr. Tingley’s work demonstrates the complex ways that species are responding to climate change, often by shifting in space and traveling in time.

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Workshop / Seminar Thu, 08 Aug 2019 11:31:18 -0400 2019-09-19T16:00:00-04:00 2019-09-19T17:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Thursday Seminar Tingley
Mary-Claire King, PhD [2019 MaryFran Sowers Memorial Lecture] (September 19, 2019 4:00pm) https://events.umich.edu/event/63376 63376-16161554@events.umich.edu Event Begins: Thursday, September 19, 2019 4:00pm
Location: Public Health II
Organized By: Center for Midlife Science

A pre-eminent scholar, Dr. King leads studies to understand the genetic causes of serious human disorders including breast and ovarian cancer and schizophrenia. Her work focuses on disentangling genetic heterogeneity in complex traits, and on discovering rare alleles that cause common disorders. From her ground-breaking doctoral dissertation that transformed evolutionary biology to her formative work proving the existence of a major gene for a complex trait that demonstrated the genetic inheritance of breast cancer, Dr. King has contributed significantly to the advancement of scientific knowledge of genetics. Most recently, her laboratory developed and patented a targeted capture and massively parallel sequencing approach (BROCA) that detects mutations in breast and ovarian cancer genes.

A leading human rights advocate, Dr. King pioneered the development of genomics tools for human rights investigations including use of mitochondrial DNA (mtDNA) sequencing to match kidnapped children to possible maternal relatives after the end of Argentinian dictatorship of 1975-1983. Her approach is now used by governmental and United Nations forensic teams worldwide to identify remains of victims of extra-judicial execution and missing soldiers.

Dr. King received her PhD in Genetics from the University of California at Berkeley, and her postdoctoral training at UC San Francisco. A professor at UC Berkeley from 1976-1995, she has been the American Cancer Society Professor of Medical Genetics and Genome Sciences at the University of Washington since 1995. She is a member of the National Academy of Medicine (1994), the American Academy of Arts and Sciences (1999), and the National Academy of Sciences (2005) and is a past President of the American Society of Human Genetics. Among her many honors, she was awarded the Lasker-Koshland Special Achievement Award in Medical Science (2014), the National Medal of Science (2016) and the Advocacy Award of the American Society of Human Genetics (2018).
A reception, sponsored by UM Precision Health, will immediately follow the lecture.

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Lecture / Discussion Mon, 16 Sep 2019 14:10:55 -0400 2019-09-19T16:00:00-04:00 2019-09-19T17:30:00-04:00 Public Health II Center for Midlife Science Lecture / Discussion Mary-Claire King, PhD
Unconventional techniques of imaging and microscopy for bio-medical applications. (September 19, 2019 4:00pm) https://events.umich.edu/event/62913 62913-15494564@events.umich.edu Event Begins: Thursday, September 19, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


Over the last few years a significant effort has been directed towards unconventional imaging techniques, such as microscopy without lenses as it can overcome some of the drawbacks associated with tradition optical microscopy, that rely on objective lenses, which results in a trade-off between the field of view and the resolution. Thus lens-less microscopy allows imaging and analysis over a wide area, enabling high throughput measurements, in addition to being cost-effective and portable. In this type of microscopy, the images are computationally reconstructed from in-line holograms, which result from the interference between the scattered optical wave from the sample and the directly transmitted wave. Here, I will present about lens-free on-chip microscopy designs, image reconstruction and its utility towards a wide range of applications related to sizing of nanoparticles, nanoparticle-aggregation, bio-sensing of pathogens and rare cancer cells, characterization of polymer degradation, material properties and rheology.











Aniruddha Ray

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Other Thu, 19 Sep 2019 18:15:48 -0400 2019-09-19T16:00:00-04:00 2019-09-19T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
UM Structure Seminar: Destabilization of the Human KCNQ1 Potassium Channel is the Most Common Cause of Long QT Syndrome Cardiac Arrhythmia (September 20, 2019 10:00am) https://events.umich.edu/event/65036 65036-16507306@events.umich.edu Event Begins: Friday, September 20, 2019 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

Charles Sanders, Ph.D.
Associate Dean for Research
Vanderbilt School of Medicine Basic Sciences

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Lecture / Discussion Thu, 08 Aug 2019 10:51:50 -0400 2019-09-20T10:00:00-04:00 2019-09-20T11:00:00-04:00 Life Sciences Institute U-M Structural Biology Lecture / Discussion Life Sciences Institute
Biophysics Talk Title: "Emerging methods in solution NMR and applications to illuminate blind spots in human biology” (September 20, 2019 12:00pm) https://events.umich.edu/event/64267 64267-16274479@events.umich.edu Event Begins: Friday, September 20, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: TBD

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Workshop / Seminar Wed, 04 Sep 2019 14:42:29 -0400 2019-09-20T12:00:00-04:00 2019-09-20T13:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
MCDB Seminar: Developmental Origins of Neural Circuits in Drosophila (September 20, 2019 12:00pm) https://events.umich.edu/event/64082 64082-16115266@events.umich.edu Event Begins: Friday, September 20, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Josie Clowney

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Workshop / Seminar Tue, 27 Aug 2019 17:12:34 -0400 2019-09-20T12:00:00-04:00 2019-09-20T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Confocal image of multicolor stained intact Drosophila larva
CSIEUM - Seminar TBD (September 20, 2019 4:00pm) https://events.umich.edu/event/64957 64957-16495250@events.umich.edu Event Begins: Friday, September 20, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

ChemEd
Darryl Boyd

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Other Fri, 20 Sep 2019 18:15:47 -0400 2019-09-20T16:00:00-04:00 2019-09-20T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Dr. Kevin Wood Tenure Talk (September 20, 2019 4:00pm) https://events.umich.edu/event/67138 67138-16805204@events.umich.edu Event Begins: Friday, September 20, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: TBD

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Workshop / Seminar Fri, 13 Sep 2019 12:28:49 -0400 2019-09-20T16:00:00-04:00 2019-09-20T17:30:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
Gateway NMR Meeting (September 21, 2019 8:00am) https://events.umich.edu/event/64651 64651-16404987@events.umich.edu Event Begins: Saturday, September 21, 2019 8:00am
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Registration: https://sites.google.com/umich.edu/gatewaynmr2019/home

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Meeting Fri, 26 Jul 2019 15:01:32 -0400 2019-09-21T08:00:00-04:00 2019-09-21T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Meeting Chemistry Dow Lab
Gateway NMR Meeting (September 22, 2019 8:00am) https://events.umich.edu/event/64651 64651-16404988@events.umich.edu Event Begins: Sunday, September 22, 2019 8:00am
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Registration: https://sites.google.com/umich.edu/gatewaynmr2019/home

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Meeting Fri, 26 Jul 2019 15:01:32 -0400 2019-09-22T08:00:00-04:00 2019-09-22T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Meeting Chemistry Dow Lab
MedChem Seminar (September 23, 2019 10:00am) https://events.umich.edu/event/67530 67530-16890100@events.umich.edu Event Begins: Monday, September 23, 2019 10:00am
Location:
Organized By: Department of Medicinal Chemistry

"Chemistry & Biology of Human DNA Ligases"

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Lecture / Discussion Mon, 23 Sep 2019 10:18:45 -0400 2019-09-23T10:00:00-04:00 2019-09-23T11:00:00-04:00 Department of Medicinal Chemistry Lecture / Discussion
MedChem Seminar (September 23, 2019 10:00am) https://events.umich.edu/event/67530 67530-16890101@events.umich.edu Event Begins: Monday, September 23, 2019 10:00am
Location:
Organized By: Department of Medicinal Chemistry

"Chemistry & Biology of Human DNA Ligases"

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Lecture / Discussion Mon, 23 Sep 2019 10:18:45 -0400 2019-09-23T10:00:00-04:00 2019-09-23T11:00:00-04:00 Department of Medicinal Chemistry Lecture / Discussion
Seminar: Haining Zhong, Ph.D., Vollum Institute (September 24, 2019 10:00am) https://events.umich.edu/event/65687 65687-16629896@events.umich.edu Event Begins: Tuesday, September 24, 2019 10:00am
Location: Biological Sciences Building
Organized By: Life Sciences Institute (LSI)

Speaker:
Haining Zhong, Ph.D.
Associate Professor
Vollum Institute, Oregon Health & Science University

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Lecture / Discussion Fri, 23 Aug 2019 13:59:32 -0400 2019-09-24T10:00:00-04:00 2019-09-24T11:00:00-04:00 Biological Sciences Building Life Sciences Institute (LSI) Lecture / Discussion Biological Sciences Building
Complex Systems Seminar | Statistical Mechanics of Microbiomes (September 24, 2019 11:30am) https://events.umich.edu/event/63981 63981-16051364@events.umich.edu Event Begins: Tuesday, September 24, 2019 11:30am
Location: Weiser Hall
Organized By: The Center for the Study of Complex Systems

Abstract: Next-generation sequencing, high-throughput metabolomics and other measurement technologies have opened vast new horizons for collecting data on the structure and function of microbial communities. But it remains unclear how to leverage this data for effective intervention in medical and agricultural applications. We do not know which quantities can be reliably predicted, which are hopelessly contingent, and what the predictors are for the former. In this talk, I will draw on conceptual tools from Statistical Physics, which were designed to answer precisely these sorts of questions. In particular, I will argue that the key features of community structure are encoded in a susceptibility matrix, which contain the response of species population sizes to small changes in growth rates. I will show how to estimate this matrix in different scenarios from existing data sets, and then explain how it can be used to cluster species into functionally redundant groups for enhanced predictability of community composition.

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Workshop / Seminar Wed, 18 Sep 2019 15:55:41 -0400 2019-09-24T11:30:00-04:00 2019-09-24T13:00:00-04:00 Weiser Hall The Center for the Study of Complex Systems Workshop / Seminar Robert Marsland Photo
EEB Tuesday Lunch Seminar: Fantastic fishes and where to find them - using historical natural history data and robots to explore deep sea fish biodiversity (September 24, 2019 12:00pm) https://events.umich.edu/event/64996 64996-16501295@events.umich.edu Event Begins: Tuesday, September 24, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

The deep ocean is frequently assumed to be a homogeneous system lacking the same diverse natural history found in shallower waters. However, as our methods for exploring the deep ocean improve, common assumptions about dispersal, reproduction and behavior are constantly being challenged. With the immense amount of data collected and stored in natural history collections to highlight historical distributions of fishes we can now use these data in concert with modern sampling methods like remote operated vehicles (ROVs) and precision netting to learn more about one of the planets most extreme systems. Join Randy as he takes you on a journey from the highest shelves of museum collections to the extreme depths of the ocean in a quest to learn more about fishes, and where to find them.

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Workshop / Seminar Fri, 20 Sep 2019 09:50:00 -0400 2019-09-24T12:00:00-04:00 2019-09-24T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Museum fish specimen on display
Rowena Matthews Lectureship in Biological Chemistry (September 24, 2019 12:00pm) https://events.umich.edu/event/65273 65273-16563500@events.umich.edu Event Begins: Tuesday, September 24, 2019 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Wilfred van der Donk will present the 2nd annual Rowena Matthews Lectureship in Biological Chemistry on Tuesday September 24th, 2019. The title of this talk is "Natural Product Biosynthesis by Post Translational Modification." The lecture will be held in Medical Science Unit II from 12:00pm to 1:00pm.

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Lecture / Discussion Wed, 18 Sep 2019 06:17:48 -0400 2019-09-24T12:00:00-04:00 2019-09-24T13:00:00-04:00 Medical Science Unit II Biological Chemistry Lecture / Discussion Wilfred van der Donk, Ph.D.
Advancing The Original Cope Rearrangement: Fundamental studies and applications in complex molecule synthesis (September 24, 2019 4:00pm) https://events.umich.edu/event/63771 63771-15873581@events.umich.edu Event Begins: Tuesday, September 24, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The original Cope rearrangement is an underutilized transformation in modern organic synthesis. Recognizing its potential, the Grenning lab seeks to transform this age old reaction into a versatile platform for complex molecule synthesis. Presented will be synthetic strategy, methodology, and applications in synthesis whereby this reaction plays a central role.








Alex Grenning (University of Florida)

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Other Tue, 24 Sep 2019 18:15:45 -0400 2019-09-24T16:00:00-04:00 2019-09-24T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Saltiel Life Sciences Symposium (September 25, 2019 8:45am) https://events.umich.edu/event/64209 64209-16212197@events.umich.edu Event Begins: Wednesday, September 25, 2019 8:45am
Location: Palmer Commons
Organized By: Life Sciences Institute (LSI)

The 2019 Saltiel Life Sciences Symposium will bring pioneers in the field of protein engineering to the University of Michigan to discuss the scientific advances driving the field forward.

Schedule:

8:45 a.m. | Welcome
Roger D. Cone, Ph.D.
Vice Provost and Director, U-M Biosciences Initiative; Mary Sue Coleman Director, Life Sciences Institute; Professor of Molecular and Integrative Physiology, Medical School; Professor of Molecular, Cellular, and Developmental Biology, College of Literature, Science, and the Arts

Mark S. Schlissel, M.D., Ph.D.
President of the University of Michigan

8:55 a.m. | Introduction of the Mary Sue and Kenneth Coleman Life Sciences Lecturer
Alan R. Saltiel, Ph.D.
Director, Institute for Diabetes and Metabolic Health, and Professor, University of California, San Diego School of Medicine; Director, Life Sciences Institute 2002-2015

9:00 a.m. | Mary Sue and Kenneth Coleman Life Sciences Lecture — Attacking the cell surface proteome in cancer
James A. Wells, Ph.D.
Harry W. and Diana V. Hind Distinguished Professor of Pharmaceutical Sciences, Professor of Pharmaceutical Chemistry, University of California, San Francisco

9:50 a.m. | Morning break

10:10 a.m. | Optogenetic and chemogenetic technologies for mapping molecular and cellular interactions
Alice Y. Ting, Ph.D.
Professor of Genetics, Biology, and Chemistry, Stanford University

11:00 a.m. | How do proteins evolve
Dan Tawfik, Ph.D.
Professor, Department of Biomolecular Sciences, Weizmann Institute of Science

11:50 a.m. | Poster session and lunch

1:20 p.m. | Biosystems design via directed evolution
Huimin Zhao, Ph.D.
Steven L. Miller Chair, Department of Chemical and Biomolecular Engineering; Professor of Chemistry, Biochemistry, Biophysics, an Bioengineering, University of Illinois at Urbana-Champaign

2:10 p.m. | Navigating the landscapes of protein interaction specificity
Amy E. Keating, Ph.D.Professor of Biology and Biological Engineering, Massachusetts Institute of Technology

3:00 p.m. | Afternoon break

3:20 p.m. |Design, evolution and applications of protein cages
Donald Hilvert, Ph.D.
Professor, Department of Chemistry and Applied Biosciences, ETH Zürich

4:10 p.m. | Closing remarks

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Conference / Symposium Thu, 29 Aug 2019 10:13:02 -0400 2019-09-25T08:45:00-04:00 2019-09-25T16:15:00-04:00 Palmer Commons Life Sciences Institute (LSI) Conference / Symposium 2019 Saltiel Life Sciences Symposium
DCMB Seminar, "Bioinformatics in Drug Discovery" (September 25, 2019 2:30pm) https://events.umich.edu/event/66407 66407-16734206@events.umich.edu Event Begins: Wednesday, September 25, 2019 2:30pm
Location: Taubman Biomedical Science Research Building
Organized By: DCMB Seminar Series

Abstract:
She’ll be describing the technologies and datasets her team uses to study human disease and develop new and improved treatments for their clients. She’ll cover the applications of traditional transcriptional profiling and sequence analysis as well as datasets and tools developed specifically for therapeutics development including CMap, Project Achilles, PRISM, functional CRISPR screening and others. She’ll also touch on topics like biomarker development, patient selection/stratification and gene therapy development. Along the way, she’ll describe what it’s like to work as a consultant, and how it differs from academic work or direct employment in the pharmaceutical industry.

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Lecture / Discussion Thu, 05 Sep 2019 11:01:32 -0400 2019-09-25T14:30:00-04:00 2019-09-25T15:30:00-04:00 Taubman Biomedical Science Research Building DCMB Seminar Series Lecture / Discussion
CDB-DEI Seminar - Oncomodulin an enigmatic parvalbumin protein (September 26, 2019 10:00am) https://events.umich.edu/event/65617 65617-16621824@events.umich.edu Event Begins: Thursday, September 26, 2019 10:00am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

2019 Cell & Developmental Biology Seminar Series

Hosted By:
Jacqueline Graniel- CDB Student
Ashley Velez- CDB Student
Flor Mendez- CDB Student

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Lecture / Discussion Thu, 22 Aug 2019 16:54:53 -0400 2019-09-26T10:00:00-04:00 2019-09-26T11:00:00-04:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion CDB Seminar - Simmons
Genes, mechanisms and the possibility of interventional therapies in common craniofacial malformations (September 26, 2019 12:00pm) https://events.umich.edu/event/67496 67496-16866599@events.umich.edu Event Begins: Thursday, September 26, 2019 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

Oral Health Sciences Seminar Series

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Presentation Fri, 20 Sep 2019 14:10:04 -0400 2019-09-26T12:00:00-04:00 2019-09-26T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Presentation Timothy Cox
EEB Thursday Seminar: The evolution of mammalian pregnancy: the path from pathology to physiology (September 26, 2019 4:00pm) https://events.umich.edu/event/65469 65469-16603596@events.umich.edu Event Begins: Thursday, September 26, 2019 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

There is a broadly recognized ambiguity in the relationship between mammalian (eutherian) pregnancy and inflammation. During implantation, inflammatory pathways are activated and important for successful implantation, but during the second trimester, intrauterine inflammation is a grave threat to the continuation of pregnancy. An investigation of the gene expression changes during opossum pregnancy led us to propose and test a model for the origin of eutherian implantation and pregnancy. In brief: if we take the opossum gestation as a model of the situation at the most recent common ancestor of marsupials and placental mammals, the evidence suggests that an acute inflammation is the result of the attachment of the trophoblast to the uterine epithelium. The difference between opossum and the eutherians is the outcome: In opossum the inflammation directly leads to parturition, while in eutherians inflammation never leads to neutrophil infiltration and soon is turned off. I will present evidence suggesting that one key innovation to achieve sustainable implantation was the origin of the decidual cell, which prevents the recruitment of neutrophils and thus prevents the development of an acute inflammation during implantation.

View YouTube video of seminar: https://youtu.be/cec0A_iwmLI

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Workshop / Seminar Mon, 06 Apr 2020 20:07:56 -0400 2019-09-26T16:00:00-04:00 2019-09-26T17:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Dr. Wagner EEB Seminar
2019 Functional MRI Symposium (September 27, 2019 9:00am) https://events.umich.edu/event/63526 63526-15782015@events.umich.edu Event Begins: Friday, September 27, 2019 9:00am
Location: East Hall
Organized By: Functional MRI Lab

The Functional MRI Laboratory is dedicated to supporting research on the structures and functions of the brain that underlie cognitive and affective processes in normal and clinical populations, as well as research on non-invasive methods for functional MRI and associated research tools, including brain stimulation.

The day will be devoted to talks that cover a range of issues having to do with data analysis, and, of course, connecting these issues to relevant topics in psychology and neuroscience.

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Conference / Symposium Fri, 13 Sep 2019 08:58:47 -0400 2019-09-27T09:00:00-04:00 2019-09-27T16:00:00-04:00 East Hall Functional MRI Lab Conference / Symposium Autumn reflections 23
Biophysics Talk Title: "Mapping the Ligand Binding Landscape" (September 27, 2019 12:00pm) https://events.umich.edu/event/64270 64270-16274480@events.umich.edu Event Begins: Friday, September 27, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: TBD

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Workshop / Seminar Wed, 04 Sep 2019 14:43:16 -0400 2019-09-27T12:00:00-04:00 2019-09-27T13:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
MCDB Seminar: Tumor Initiation and Progression in a Simple Model (September 27, 2019 12:00pm) https://events.umich.edu/event/64085 64085-16115269@events.umich.edu Event Begins: Friday, September 27, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Laura Buttitta

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Workshop / Seminar Tue, 10 Sep 2019 16:53:29 -0400 2019-09-27T12:00:00-04:00 2019-09-27T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar transition zone model. showing Drosophila tissue stained blue
Oxidative Stress Sensing Mechanism by KEAP1 (September 27, 2019 2:00pm) https://events.umich.edu/event/65618 65618-16621825@events.umich.edu Event Begins: Friday, September 27, 2019 2:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

2019 Cell & Developmental Biology Seminar Series

Hosted By: Doug Engel, PhD

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Lecture / Discussion Thu, 22 Aug 2019 17:00:56 -0400 2019-09-27T14:00:00-04:00 2019-09-27T15:00:00-04:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion CDB Seminar - Yamamoto
How Does a Single Protein Molecule Cause an Array of Diseases? The Story of the Magic Protein NLRP3 (September 27, 2019 3:15pm) https://events.umich.edu/event/64660 64660-16410958@events.umich.edu Event Begins: Friday, September 27, 2019 3:15pm
Location: Off Campus Location
Organized By: Osher Lifelong Learning Institute (50+)

In some cases, the malfunction of a signal molecule in our body causes diseases. Here the protein NLRP3 will be taken as an example. The course will first provide the basic background of molecular cell biology, such as the concepts of cell and its building blocks; then introduce NLRP3, its function in the normal condition and its relations with diseases, such as auto-inflammatory disorders, type 2 diabetes, gout, Alzheimer disease, etc.
The goal of this course is to bring science to the community and highlight the importance of basic biological research in medicine. Jie Xu, instructor, has a Ph.D. in neuroscience and has worked as a postdoctoral researcher at the University of Michigan Medical School since 2018. This Study Group is for those 50 and over and meets Fridays, 3:15–4:45 pm on September 27 – October 4.

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Class / Instruction Sat, 27 Jul 2019 09:54:46 -0400 2019-09-27T15:15:00-04:00 2019-09-27T16:45:00-04:00 Off Campus Location Osher Lifelong Learning Institute (50+) Class / Instruction Study Group
Precision Health Analytics Platform Roadshow (September 30, 2019 3:30pm) https://events.umich.edu/event/66952 66952-16787744@events.umich.edu Event Begins: Monday, September 30, 2019 3:30pm
Location: Michigan League
Organized By: Precision Health

Are you a health researcher looking for genetic and clinical data, or do you need assistance in data analysis?

Precision Health’s new Analytics Platform is a suite of tools, services, and datasets available to researchers across campus--resources previously available only to Michigan Medicine faculty and other level-two password holders. The platform provides campus-wide access to research tools such as DataDirect and services such as consultation with scientific facilitators.

Attend a roadshow to learn how to access the platform and what you can do with it:

• Perform cohort discovery on a database of 4M+ patients
• Query a de-identified, structured dataset of ~60K patients
• Submit queries through the self-serve tool DataDirect
• Access output via a secure, HIPAA-compliant environment
• Request access to linked genetic data (with IRB approval)

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Presentation Tue, 24 Sep 2019 14:05:28 -0400 2019-09-30T15:30:00-04:00 2019-09-30T16:30:00-04:00 Michigan League Precision Health Presentation DataDirect
"RNA Therapeutics: The Future of Human Medicine" (September 30, 2019 4:00pm) https://events.umich.edu/event/65135 65135-16539446@events.umich.edu Event Begins: Monday, September 30, 2019 4:00pm
Location: Palmer Commons
Organized By: Center for RNA Biomedicine

Please join us immediately after Anastasia's talk for a welcome reception in Palmer Commons Atrium (4th floor).


ABSTRACT: With the first drugs approved, oligonucleotides are rising to become a new, major class of therapeutic modalities on par with small molecules and biologics.
RNAi enables simple and specific modulation of gene expression when the chemical architecture supporting efficient delivery in vivo is defined. Currently, in liver, a single subcutaneous administration supports a year of clinical efficacy, changing our vision of how medicine will be practiced in the future.
The unprecedented duration of effect relies on oligonucleotide endocytosis and entrapment within endosomal/lysosomal compartments. These naturally formed, intracellular deposits provide a continuous release of compounds for RISC loading and productive silencing, supporting multi-month efficacy. Of course, this approach is dependent on extensive and complex chemical stabilization that ensures the survival of the oligonucleotides in highly aggressive biological environments.
In the context of fully stabilized compounds, we have used diverse chemical engineering to define the rules driving oligonucleotide distribution, efficacy, and toxicity. At this point, efficient modulation of gene expression in multiple extrahepatic tissues is possible (muscle, heart, fat, placenta, etc). One of our engineering efforts resulted in the identification of a di-branched chemical scaffold that enables potent and durable gene silencing in the brain and spinal cord. Using huntingtin – the causative gene in Huntington disease – as a model, we demonstrate that CNS-active RNAi induces potent protein silencing (~ 90%) in all brain regions tested in both rodents and non-human primates. Silencing persists for at least six months, with the degree of gene modulation correlating to the level of the guide strand tissue accumulation.
Demonstration of extrahepatic activity, in particular the development of a CNS-active RNAi scaffold, is opening other tissues and the brain for RNAi-based modulation of gene expression and establishing a path toward the development of new cures for genetically-defined neurodegenerative disorders.

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Lecture / Discussion Fri, 13 Sep 2019 13:47:57 -0400 2019-09-30T16:00:00-04:00 2019-09-30T17:00:00-04:00 Palmer Commons Center for RNA Biomedicine Lecture / Discussion speaker photo
Cellular Lipid Homeostasis: From Lipid Droplets to Lipotoxicity- Department of Biological Chemistry Seminar (October 1, 2019 12:00pm) https://events.umich.edu/event/67253 67253-16829027@events.umich.edu Event Begins: Tuesday, October 1, 2019 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

The Department of Biological Chemistry is hosting a seminar given by Dr. James Olzmann, Associate Professor in the Department of Nutritional Sciences and Toxicology, UC Berkeley on Tuesday October 1, 2019. The seminar will take place at 12:00 noon in North Lecture Hall, MS II

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Workshop / Seminar Mon, 16 Sep 2019 11:24:45 -0400 2019-10-01T12:00:00-04:00 2019-10-01T13:00:00-04:00 Medical Science Unit II Biological Chemistry Workshop / Seminar James Olzmann
Community-Based Participatory Research (Panel Discussion) (October 1, 2019 12:00pm) https://events.umich.edu/event/67624 67624-16907171@events.umich.edu Event Begins: Tuesday, October 1, 2019 12:00pm
Location: Public Health I (Vaughan Building)
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Three (3) U-M experts will lead a Panel Discussion on Community-Based Participatory Research, including: Neeraja Aravamudan, PhD (Assoc. Director, Teaching & Research, Ginsberg Center); Barbara Israel, DrPH (Director, Detroit Community-Academic Urban Research Center); Erica E. Marsh, MD (Director of Community Engagement, MI Institute for Clinical & Health Research). Discussants will share their experiences with creating equitable partnerships between community members and academic researchers, and touch on some of the challenges. There will be time for Q&A too. Please join us for a stimulating discussion, and feel free to bring your lunch.

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Lecture / Discussion Wed, 25 Sep 2019 11:09:56 -0400 2019-10-01T12:00:00-04:00 2019-10-01T12:50:00-04:00 Public Health I (Vaughan Building) Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Community-Based Participatory Research
EEB Tuesday Lunch Seminar: Imperiled plants of tropical rivers: Phylogeny, biogeography, and systematics of Podostemaceae (October 1, 2019 12:00pm) https://events.umich.edu/event/64998 64998-16501296@events.umich.edu Event Begins: Tuesday, October 1, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Please join us for our weekly brown bag lunch seminar

Abstract
The riverweed family (Podostemaceae) is the largest strictly aquatic family of flowering plants and provides important habitats and food sources for many fishes and aquatic invertebrates. Highly unusual for flowering plants, species grow directly attached to rocks in river-rapids and waterfalls. Podostemaceae species exhibit high phenotypic plasticity and have highly modified growth forms, both of which contribute to taxonomic confusion. Many of the estimated 300 riverweed species are narrowly distributed and incompletely known, and evolutionary relationships within the family are uncertain. Unfortunately, many species are of conservation concern and risk extinction due to the expansion of hydroelectric dams and massive reservoirs. This talk will detail the progress on a collaborative project to better understand the phylogeny, biogeography, and systematics of Podostemaceae. In particular, we aim to better understand the biogeographical history of neotropical riverine organisms and the role that major river capture events during the Cenozoic have played in their distribution. The project includes significant fieldwork, monographic work, and an investigation of the structural organization of the family’s plastid genome. Finally, we are also developing a new online resource designed to broadly disseminate information on the family as well as a new tool for the systematics community to more easily manage monographic data for publication.

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Workshop / Seminar Tue, 24 Sep 2019 14:24:34 -0400 2019-10-01T12:00:00-04:00 2019-10-01T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Riverweed
A periosteal stem cell and the cellular basis of intramembranous versus endochondral ossification (October 1, 2019 4:00pm) https://events.umich.edu/event/65743 65743-16651986@events.umich.edu Event Begins: Tuesday, October 1, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for Cell Plasticity and Organ Design

2019 - 2020 Center for Organogenesis Seminar Series
Faculty Host: Noriaki Ono
For additional information contact: organogenesis@umich.edu

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Lecture / Discussion Mon, 26 Aug 2019 09:00:56 -0400 2019-10-01T16:00:00-04:00 2019-10-01T17:00:00-04:00 Taubman Biomedical Science Research Building Center for Cell Plasticity and Organ Design Lecture / Discussion A periosteal stem cell and the cellular basis of intramembranous versus endochondral ossification.”
Human Genetics Seminar Series (October 1, 2019 4:00pm) https://events.umich.edu/event/67696 67696-16918022@events.umich.edu Event Begins: Tuesday, October 1, 2019 4:00pm
Location: Buhl Res Cen for Human Genetics
Organized By: Human Genetics

Seminar Title: Cardiovascular Genomics for Precision Medicine: Emerging Lessons from Framingham to MegaBiobanks

Tuesday, October 1, 2019
4:00-5:00 PM
5915 Buhl Classroom

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Other Thu, 26 Sep 2019 15:13:14 -0400 2019-10-01T16:00:00-04:00 2019-10-01T16:00:00-04:00 Buhl Res Cen for Human Genetics Human Genetics Other
Synthesis and Reactivity of a Terminal Co Oxo Complex (October 1, 2019 4:00pm) https://events.umich.edu/event/63512 63512-15767677@events.umich.edu Event Begins: Tuesday, October 1, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Transition metal oxo complexes, particularly those of later transition metals, have been cited as important intermediates in processes such as C-H hydroxylation and oxygen evolution. In general, however, these species are highly reactive and difficult to isolate and study. In this talk I will present our laboratories efforts at isolating and studying late transition metal oxo complexes. We have found that use of pseudo-tetrahedral geometries enables the isolation of an unusual terminal Co-oxo complex. The reactivity of this species towards C-H activation is markedly different than that observed for the majority of other systems and provides experimental evidence for a new mechanistic scenario dubbed "asynchronous" CPET. Finally, the possible relevance of related Co and Ni complexes in this system towards O-O bond formation will be discussed.
John Anderson (University of Chicago)

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Other Tue, 01 Oct 2019 18:15:55 -0400 2019-10-01T16:00:00-04:00 2019-10-01T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Writing a Competitive Research Grant Proposal (October 2, 2019 9:00am) https://events.umich.edu/event/66542 66542-16744994@events.umich.edu Event Begins: Wednesday, October 2, 2019 9:00am
Location: Institute For Social Research
Organized By: OVPR Office of Research Development

This workshop discusses writing grant proposals for various sponsors, including federal agencies (e.g., NIH, NSF) and foundation funders.
Topics include:
-Resources at U-M to help you find funding opportunities and develop proposals
-Self-assessment
-Analyzing sponsors
-How the review process works
-How to write various proposals sections
-General writing tips

Email Jill Jividen at jjgoff@umich.edu with questions.

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Workshop / Seminar Mon, 09 Sep 2019 08:52:54 -0400 2019-10-02T09:00:00-04:00 2019-10-02T12:00:00-04:00 Institute For Social Research OVPR Office of Research Development Workshop / Seminar
Special Joint Lecture (MICHR and DCMB) (October 2, 2019 4:00pm) https://events.umich.edu/event/67257 67257-16829032@events.umich.edu Event Begins: Wednesday, October 2, 2019 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract: Dr. Haendel’s vision is to weave together healthcare systems, basic science research, and patient generated data through development of data integration technologies and innovative data capture strategies. The Monarch Initiative is an international consortium dedicated to integrating human and organismal genotype-phenotype data and the development of deep phenotyping techniques. This talk will focus on the use of ontologies to support knowledge and data integration across disciplinary boundaries. Strategies for how to reconcile different terminologies and examples of harmonized semantic structures for anatomy, phenotype, and disease will be discussed. Finally, we will discuss the use of these ontological resources to populate graph structures and their use to aid mechanism discovery and rare disease diagnosis.

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Lecture / Discussion Mon, 16 Sep 2019 11:53:44 -0400 2019-10-02T16:00:00-04:00 2019-10-02T17:00:00-04:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
EEB Thursday Seminar: Locating and learning from bright spots among the world’s coral reefs (October 3, 2019 4:00pm) https://events.umich.edu/event/65470 65470-16660096@events.umich.edu Event Begins: Thursday, October 3, 2019 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

The continuing and rapid global decline of coral reefs calls for new approaches to sustain reefs and the millions of people who depend on them. In this talk, I present ongoing work by my research group aimed at rethinking reef conservation along two lines. First is directly confronting the drivers of change. In addition to environmental factors, there are socioeconomic drivers that influence the condition of coral reef ecosystems, though reef governance rarely focus on explicitly managing these. My colleagues and I analyzed data from >1800 tropical reef sites worldwide to quantify how key socioeconomic and environmental drivers are related to reef fish biomass, a key indicator of ecosystem condition and resource availability. Our global analysis reveals that the strongest driver of reef fish biomass is our metric of potential interactions with urban centres (market gravity), with important, but smaller, roles of local management, human demographics, socioeconomic development, and environmental conditions. These results highlight multiple underutilized policy levers that could help to sustain coral reefs, such as dampening the negative impact of markets. Second, drawing on theory and practice in human health and rural development, we use a positive deviance (bright spots) analysis to systematically identify coral reefs that have substantially higher biomass than expected, given their socioeconomic and environmental conditions. Importantly, bright spots were not simply comprised of remote areas with low fishing pressure- they include localities where human populations and use of ecosystems resources is high, potentially providing novel insights into how communities have successfully confronted strong drivers of change. Uncovering the mechanisms that underpin the ability of bright spots to confront high pressures may form a basis for novel policy approaches.

View YouTube video of seminar: https://youtu.be/qVywZwcWMiY

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Workshop / Seminar Thu, 02 Apr 2020 12:52:07 -0400 2019-10-03T16:00:00-04:00 2019-10-03T17:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Cinner photo
MedChem Seminar (October 3, 2019 4:00pm) https://events.umich.edu/event/67530 67530-16890098@events.umich.edu Event Begins: Thursday, October 3, 2019 4:00pm
Location: Pharmacy College
Organized By: Department of Medicinal Chemistry

"Chemistry & Biology of Human DNA Ligases"

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Lecture / Discussion Mon, 23 Sep 2019 10:18:45 -0400 2019-10-03T16:00:00-04:00 2019-10-03T17:00:00-04:00 Pharmacy College Department of Medicinal Chemistry Lecture / Discussion Pharmacy College
Nonadiabatic and Quantum Dynamics in Materials (October 3, 2019 4:00pm) https://events.umich.edu/event/63379 63379-15663386@events.umich.edu Event Begins: Thursday, October 3, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Dynamics of excited states plays a determining role in many materials such as solar cells, photocatalysts, or photo-actuated molecular switches. Electron-hole recombination, interfacial charge transfer, nonradiative excitation energy relaxation, photoinduced nuclear reorganization, and bond breaking - all require accounting for nonadiabatic (NA) effects. Nuclear tunneling and zero-point energies constitute quantum nuclear effects that may non-trivially affect the electron-nuclear dynamics. Understanding details of nonadiabatic and quantum dynamics (NA/QD) at the atomistic level requires advanced tools and methodologies. Often, one also needs to address the computational limitations due to systems’ sizes and processes’ time scales, what makes modeling NA/QD in realistic materials a challenging problem.
Over the past few years, my group has been addressing various methodological problems in NA/QD to enable computationally affordable yet reasonably accurate modeling of excited states dynamics in extended atomistic systems. In this presentation, I will overview several approaches we have developed in this regard and will illustrate their utility in modeling charge transfer dynamics in organic and inorganic solar-harvesting systems. The developments in three key areas will be highlighted: a) modeling NA/QD in extended systems via simplified semiclassical and fragmentation approaches as well as via innovative software that leverage linear-scaling electronic structure methods; b) modeling slow NA/QD via the machine-learning-inspired quasi-stochastic Hamiltonian approach and via the enhanced sampling scheme; c) accounting for quantum nuclear effects via the entangled trajectories Hamiltonian dynamics (ETHD) method. Along the way, I will touch on other important methodological questions such as the role of phase correction, decoherence, and the effect of electronic structure choice. Last but not least, I will highlight chemical insights we have gained from the NA/QD modeling in all-inorganic perovskites, quantum dots, and materials’ heterojunctions.






Alexey Akimov (University of Buffalo)

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Other Thu, 03 Oct 2019 18:15:51 -0400 2019-10-03T16:00:00-04:00 2019-10-03T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Diversity and Ecology of Virus in Human Health and the Environment (October 4, 2019 9:00am) https://events.umich.edu/event/66118 66118-16687427@events.umich.edu Event Begins: Friday, October 4, 2019 9:00am
Location: Public Health II
Organized By: MAC-EPID

MAC-EPID symposia are designed to stimulate conversation across disciplines therefore time is allotted to breaks and lunch to allow for these connections.

Speakers include:

Simon Roux, PhD (Research Scientist, DOE Joint Genome Institute, Lawrence Berkeley National Laboratory)
"Viruses in the environment: ruthless killers or essential helpers of microbes?"

Nathan Grubaugh, PhD (Assistant Professor of Epidemiology of Microbial Diseases, Yale School of Public Health)
"Genomic epidemiology to uncover the emergence and spread of Zika virus"

Sarah Cobey (Associate Professor, Ecology & Evolution, University of Chicago)
Title TBA


Please register for this free symposium since lunch will be provided. Thank you!

* * * * *

For more information and registration for this FREE event:
www.MAC-EPID.org
Anna Cronenwett, weaverd@umich.edu

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Conference / Symposium Fri, 30 Aug 2019 18:01:48 -0400 2019-10-04T09:00:00-04:00 2019-10-04T15:00:00-04:00 Public Health II MAC-EPID Conference / Symposium MAC-EPID flyer 2019
Biophysics Talk Title: TBD (October 4, 2019 12:00pm) https://events.umich.edu/event/64281 64281-16274492@events.umich.edu Event Begins: Friday, October 4, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstracts: TBD

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Workshop / Seminar Wed, 10 Jul 2019 11:27:51 -0400 2019-10-04T12:00:00-04:00 2019-10-04T13:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
CSIEUM - Seminar: Hijacking Physiological Oxygen Sensing by Small Molecule Therapeutics (October 4, 2019 12:00pm) https://events.umich.edu/event/65520 65520-16607705@events.umich.edu Event Begins: Friday, October 4, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Mike Rabinowitz (Akebia Therapeutics)

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Other Fri, 04 Oct 2019 18:16:01 -0400 2019-10-04T12:00:00-04:00 2019-10-04T13:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
MCDB Seminar: RNA Binding Proteins, Cancer-Induced Cachexia--Potential Therapy (October 4, 2019 12:00pm) https://events.umich.edu/event/67346 67346-16839903@events.umich.edu Event Begins: Friday, October 4, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Mohammed Akaaboune

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Workshop / Seminar Tue, 17 Sep 2019 15:29:02 -0400 2019-10-04T12:00:00-04:00 2019-10-04T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar collage of micrographs with MCDB letters
2019 Community Launch and Faculty Workshop (October 7, 2019 2:30pm) https://events.umich.edu/event/66275 66275-16725800@events.umich.edu Event Begins: Monday, October 7, 2019 2:30pm
Location: Rackham Graduate School (Horace H.)
Organized By: Michigan Concussion Center

You’re invited to attend the launch of the Michigan Concussion Center to hear an overview of the Center’s mission and vision and participate in a workshop to prioritize the Center’s research agendas.

When: Monday, October 7, 2019
Where: East Conference Room at Rackham Graduate School
Time: 2:30 - 4:30 p.m. Overview and Workshop
4:30 - 5:30 p.m. Reception
Who: Anyone who is interested in concussion research, clinical care, and outreach & education.

Please complete the linked survey by Friday, September 17th prior to attending the workshop. Your responses will help us prioritize research topics and set the workshop’s agenda.

Questions? Contact Michigan Concussion Center Deputy Director Carrie Morton at (734) 647-3958 or email cemorton@umich.edu.

For more information about the Michigan Concussion Center, visit concussion.umich.edu.

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Workshop / Seminar Wed, 04 Sep 2019 14:51:20 -0400 2019-10-07T14:30:00-04:00 2019-10-07T17:30:00-04:00 Rackham Graduate School (Horace H.) Michigan Concussion Center Workshop / Seminar Steve sitting with student at a table studying a laptop next to a lacrosse helmet.
RNA Innovation Seminar, Keith Slotkin, Donald Danforth Plant Science Center, University of Missouri Columbia (October 7, 2019 4:00pm) https://events.umich.edu/event/65136 65136-16539447@events.umich.edu Event Begins: Monday, October 7, 2019 4:00pm
Location: Palmer Commons
Organized By: Center for RNA Biomedicine

Keith Slotkin, Member and PI, Donald Danforth Plant Science Center,  Associate Professor, Division of Biological Sciences, University of Missouri Columbia

Abstract: The field of epigenetic silencing is replete with labs studying how transcriptional silencing is epigenetically maintained, or in some cases re-targeted, across cell divisions and generations. On the other hand, the initiation of that silencing in the first place, especially for DNA that is “new” to the genome, is not well understood. Although the propagation of epigenetic silencing is based on the chromatin level, our data in the powerful model plant Arabidopsis demonstrates that de novo initiation of transposable element and transgene silencing is based on RNA, and utilizes a host of small RNA classes that function specifically in the initiation of silencing to guide the first round of DNA methylation. I plan to present my ongoing work on the molecular mechanisms of silencing initiation, focusing on the key RNA-dependent processes necessary to initiate epigenetic silencing.

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Lecture / Discussion Wed, 25 Sep 2019 10:57:47 -0400 2019-10-07T16:00:00-04:00 2019-10-07T17:00:00-04:00 Palmer Commons Center for RNA Biomedicine Lecture / Discussion flyer
Biocatalysis of Paclitaxel Analogs and Hydroxy Amino Acids- Department of Biological Chemistry Seminar (October 8, 2019 12:00pm) https://events.umich.edu/event/67256 67256-16829030@events.umich.edu Event Begins: Tuesday, October 8, 2019 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Kevin Walker, Professor of Chemistry at Michigan State University, will give the Department of Biological Chemistry seminar on Tuesday October 8th at 12 noon in North Lecture Hall, MS II

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Workshop / Seminar Mon, 16 Sep 2019 11:24:15 -0400 2019-10-08T12:00:00-04:00 2019-10-08T13:00:00-04:00 Medical Science Unit II Biological Chemistry Workshop / Seminar
EEB Tuesday Lunch Seminar: Fuel treatments change forest structure and spatial patterns of fire severity in dry western forests (October 8, 2019 12:00pm) https://events.umich.edu/event/64999 64999-16501297@events.umich.edu Event Begins: Tuesday, October 8, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Please join us for our weekly brown bag lunch seminar.

Abstract
Fuel reduction treatments are often designed to achieve multiple resource management objectives in addition to reducing potential fire hazard. Many studies have documented reduced fire severity for a standard set of fuel treatments, but the range of variability in fuel treatment effectiveness for alternative treatment designs is poorly understood. We used nonlinear mixed-effects modeling to estimate the distance into the treated area at which fire severity decreases and randomization tests to compare forest structure. The range of variability in observed-distance high-severity fire effects persist into the treated area and, in conjunction with estimated relationships between posttreatment forest structure and severity, can inform the design of alternative fuel treatment prescriptions with various target prescriptions. Our study will inform decision makers on the size of treatments required to accomplish management objectives.

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Workshop / Seminar Fri, 04 Oct 2019 10:34:29 -0400 2019-10-08T12:00:00-04:00 2019-10-08T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar View from above of forest fire and unburned area and land beyond
Writing a Competitive Research Grant Proposal (October 8, 2019 1:00pm) https://events.umich.edu/event/66545 66545-16744999@events.umich.edu Event Begins: Tuesday, October 8, 2019 1:00pm
Location: Institute For Social Research
Organized By: OVPR Office of Research Development

This workshop discusses writing grant proposals for various sponsors, including federal agencies (e.g., NIH, NSF) and foundation funders.
Topics include:
-Resources at U-M to help you find funding opportunities and develop proposals
-Self-assessment
-Analyzing sponsors
-How the review process works
-How to write various proposals sections
-General writing tips

Email Jill Jividen at jjgoff@umich.edu with questions.

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Workshop / Seminar Mon, 09 Sep 2019 08:55:34 -0400 2019-10-08T13:00:00-04:00 2019-10-08T16:00:00-04:00 Institute For Social Research OVPR Office of Research Development Workshop / Seminar
Human Genetics Seminar Series (October 8, 2019 4:00pm) https://events.umich.edu/event/67975 67975-16977498@events.umich.edu Event Begins: Tuesday, October 8, 2019 4:00pm
Location: Buhl Res Cen for Human Genetics
Organized By: Human Genetics

Building and rebuilding the mammalian hypothalamus one cell at a time
Tuesday, October 8, 2019
4:00-5:00 PM
5915 Buhl Classroom

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Workshop / Seminar Thu, 03 Oct 2019 12:41:43 -0400 2019-10-08T16:00:00-04:00 2019-10-08T17:00:00-04:00 Buhl Res Cen for Human Genetics Human Genetics Workshop / Seminar
Solving the Polyploid Mystery in Wound Repair (October 8, 2019 4:00pm) https://events.umich.edu/event/65744 65744-16651987@events.umich.edu Event Begins: Tuesday, October 8, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for Cell Plasticity and Organ Design

2019 – 2020 Center for Organogenesis Seminar Series
Faculty Host: Laura Buttitta

For additional information contact: organogenesis@umich.edu

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Lecture / Discussion Fri, 13 Sep 2019 10:43:05 -0400 2019-10-08T16:00:00-04:00 2019-10-08T17:00:00-04:00 Taubman Biomedical Science Research Building Center for Cell Plasticity and Organ Design Lecture / Discussion Solving the Polyploid Mystery in Wound Repair_2
Medical School Student Panel Discussion (October 8, 2019 6:00pm) https://events.umich.edu/event/65981 65981-16678384@events.umich.edu Event Begins: Tuesday, October 8, 2019 6:00pm
Location: Biological Sciences Building
Organized By: Science Learning Center

Here is your chance to hear about what life is like for several medical school students and residents. Learn about each of their paths to medicine, experiences in medical school, and things they wished they had known in college. You can also submit your own questions ahead of time using the following link: http://tiny.cc/med-student-panel.

Registration Link: http://ttc.iss.lsa.umich.edu/undergrad/sessions/medical-school-student-panel-discussion-2/

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Workshop / Seminar Wed, 04 Sep 2019 15:40:54 -0400 2019-10-08T18:00:00-04:00 2019-10-08T19:00:00-04:00 Biological Sciences Building Science Learning Center Workshop / Seminar Biological Sciences Building
Precision Health Analytics Platform Roadshow (October 9, 2019 12:00pm) https://events.umich.edu/event/66953 66953-16787745@events.umich.edu Event Begins: Wednesday, October 9, 2019 12:00pm
Location: North Campus Research Complex Building 10
Organized By: Precision Health

Are you a health researcher looking for genetic and clinical data, or do you need assistance in data analysis?

Precision Health’s new Analytics Platform is a suite of tools, services, and datasets available to researchers across campus--resources previously available only to Michigan Medicine faculty and other level-two password holders. The platform provides campus-wide access to research tools such as DataDirect and services such as consultation with scientific facilitators.

Attend a roadshow to learn how to access the platform and what you can do with it:

• Perform cohort discovery on a database of 4M+ patients
• Query a de-identified, structured dataset of ~60K patients
• Submit queries through the self-serve tool DataDirect
• Access output via a secure, HIPAA-compliant environment
• Request access to linked genetic data (with IRB approval)

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Presentation Wed, 18 Sep 2019 12:33:01 -0400 2019-10-09T12:00:00-04:00 2019-10-09T13:30:00-04:00 North Campus Research Complex Building 10 Precision Health Presentation DataDirect
Biology DEI Event (October 9, 2019 1:30pm) https://events.umich.edu/event/68088 68088-17009817@events.umich.edu Event Begins: Wednesday, October 9, 2019 1:30pm
Location: Biological Sciences Building
Organized By: MCDB Graduate Student Council - MCDB-GSC

As part of Biology Week, the MCDB and EEB DE&I Committees will be hosting an information session on summer research opportunities for undergraduate students. We will also have a presentation from the Society for the Advancement of Chicanos/Hispanics and Native Americans in Science (SACNAS) organization. In addition, we will be hosting a Draw a Scientist Activity where we invite all undergrads, graduate students, postdocs, and even faculty to draw cartoon versions of themselves as scientists. These drawings will be displayed during our outreach events later in the week.
There will be free pizza at this event.

Room and Time: 1010 BSB, 1:30pm - 2:30pm

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Workshop / Seminar Mon, 07 Oct 2019 10:14:26 -0400 2019-10-09T13:30:00-04:00 2019-10-09T14:30:00-04:00 Biological Sciences Building MCDB Graduate Student Council - MCDB-GSC Workshop / Seminar Biological Sciences Building
Department of Computational Medicine & Bioinformatics Weekly Wednesday Seminar (October 9, 2019 4:00pm) https://events.umich.edu/event/68092 68092-17009821@events.umich.edu Event Begins: Wednesday, October 9, 2019 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Talk Title: "Controlling dynamic ensembles: From cells to societies"

Abstract: Natural and engineered systems that consist of populations of isolated or interacting dynamical components exhibit levels of complexity that are beyond human comprehension. These complex systems often require an appropriate excitation, an optimal hierarchical organization, or a periodic dynamical structure, such as synchrony, to function as desired or operate optimally. In many application domains, e.g., neurostimulation in brain medicine and nuclear magnetic resonance spectroscopy and imaging in quantum control, control and observation can only be implemented at the population level, through broadcasting a single input signal to all the systems in the population and through collecting aggregated system-level measurements of the population, respectively. These limitations give rise to challenging problems and new control paradigms involving underactuated manipulation of dynamic ensembles. This talk will address theoretical and computational challenges for targeted coordination of both isolated and networked ensemble systems arising in diverse areas at different scales. Both model-based and data-driven approaches for learning, decoding, control, and computation of dynamic structures and patterns in ensemble systems will be presented. Practical control designs, including synchronization waveforms for pattern formation in complex networks and optimal pulses in quantum control, will be illustrated along with their experimental realizations. Lastly, future directions and opportunities in Systems and Controls will be discussed.

3:45 p.m. - Light Refreshments Served
4:00 p.m. - Lecture

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Lecture / Discussion Mon, 07 Oct 2019 10:26:01 -0400 2019-10-09T16:00:00-04:00 2019-10-09T17:00:00-04:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
Professor Jianzhi Zhang, the Marshall W. Nirenberg Collegiate Professor of Ecology and Evolutionary Biology, Inaugural Lecture (October 9, 2019 4:00pm) https://events.umich.edu/event/64418 64418-16346364@events.umich.edu Event Begins: Wednesday, October 9, 2019 4:00pm
Location: Weiser Hall
Organized By: The College of Literature, Science, and the Arts

Molecular errors refer to mistakes made at the molecular level in cells, including, for example, misfolding of RNA or protein molecules, misincorporation of amino acids in protein synthesis, and misinteraction between biomolecules. I argue that many genome-scale patterns in molecular biology and evolution (e.g., on transcription/translation initiation site variation, alternative polyadenylation, posttranscriptional modification, chromosomal locations of genes, and protein evolutionary rate) originate from molecular errors and differential natural selection mitigating these errors. Realizing that the cellular life is far from the orderly and harmonious picture commonly portrayed is important for understanding biology.

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Lecture / Discussion Mon, 07 Oct 2019 19:42:24 -0400 2019-10-09T16:00:00-04:00 2019-10-09T17:30:00-04:00 Weiser Hall The College of Literature, Science, and the Arts Lecture / Discussion Picture
The American University of Beirut: Lifting the Quality of Health Across the Middle East and North Africa Region (October 10, 2019 10:00am) https://events.umich.edu/event/65891 65891-16668204@events.umich.edu Event Begins: Thursday, October 10, 2019 10:00am
Location: Taubman Biomedical Science Research Building
Organized By: NeuroNetwork for Emerging Therapies

Thursday, October 10, 2019
10:00 am - 10:45 am

Kahn Auditorium - Biomedical Science Research Building

Seminar is followed by an Open Panel Discussion
10:45 am - 11:30 am

Panelists from American University of Beirut include:
Dr. Mohamed Sayegh - Executive Vice President & Dean of Medicine
Dr. Alan Shihadeh - Dean of Engineering & Architecture
Dr. Iman Nuwayhid - Dean of the Faculty of Health Sciences
Drs. Sami Azar & Assad Eid - Directors of the Diabetes Program

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Lecture / Discussion Wed, 18 Sep 2019 13:48:19 -0400 2019-10-10T10:00:00-04:00 2019-10-10T11:30:00-04:00 Taubman Biomedical Science Research Building NeuroNetwork for Emerging Therapies Lecture / Discussion A Special Lecture by Dr. Fadlo R. Khuri, President of the American University of Beruit
CGIS Study Abroad Fair (October 10, 2019 12:00pm) https://events.umich.edu/event/64876 64876-16483057@events.umich.edu Event Begins: Thursday, October 10, 2019 12:00pm
Location: Michigan League
Organized By: Center for Global and Intercultural Study

Learn about 140 programs in over 50 countries, ask about U-M faculty-led programs, and figure out which program can help satisfy your major/minor requirements. CGIS has programs ranging from 3 weeks to an academic year! Meet with CGIS advisors, staff from the Office of Financial Aid and the LSA Scholarship Office, CGIS
Alumni, and other on-campus offices who can help you select a program that works best for you.

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Fair / Festival Thu, 15 Aug 2019 13:41:18 -0400 2019-10-10T12:00:00-04:00 2019-10-10T16:00:00-04:00 Michigan League Center for Global and Intercultural Study Fair / Festival PHOTO
LSI Seminar Series: Hanchuan Peng, Ph.D., Allen Institute for Brain Science (October 10, 2019 12:00pm) https://events.umich.edu/event/67683 67683-16917832@events.umich.edu Event Begins: Thursday, October 10, 2019 12:00pm
Location: Palmer Commons
Organized By: Life Sciences Institute (LSI)

Abstract:
Despite substantial advancement in the automatic tracing of brain cells' 3D morphology in recent years, it is challenging to apply existing algorithms to very large image datasets containing billions or more voxels, especially for applications such as morphometry of single neurons at the whole-brain scale. We have developed a new platform combining several newly developed technologies including Vaa3D, TeraFly, UltraTracer, and TeraVR (Nature, 2019), to attempt this challenge. Particularly, we have used TeraFly to invoke Vaa3D to quickly visualize the whole mouse brain image volume and manage the thousands of billions of voxels in each of the brain volume. We then used UltraTracer to wrap several efficient base tracers to trace such massive data volumes. Finally, we combined virtual reality and machine learning into a tool called TeraVR for efficient proofreading and editing of such reconstructed neuron morphology. We are further improving the integration of these tools for more scalable and accurate single neuron morphometry.

Speaker:
Hanchuan Peng is the director of the SEU-ALLEN Joint Center and director of advanced computing at the Allen Institute for Brain Science. His lab develops revolutionary technologies to generate, manage, visualize, analyze and understand massive-scale structure and function data related to brains. Peng also led the Big Image Mining team at Janelia, HHMI. Peng is a highly cited inventor of a number of new algorithms and software/hardware systems, including Vaa3D - a widely adopted high-performance platform for very large multi-dimensional images, BrainAligner, SmartScope, mRMR, etc. He built and co-worked the first digital maps for several widely used model systems at single cell/neurite resolution, and led the “BigNeuron” initiative. Peng was inducted into AIMBE in 2019, is a co-recipient of USA National Academy of Sciences’ Cozzarelli Prize (2013), and a recipient of the DIADEM award (2010). His work has been featured in Nature, Science, NPR, and NBC, among others.

Lunch will be provided.

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Lecture / Discussion Thu, 26 Sep 2019 13:13:18 -0400 2019-10-10T12:00:00-04:00 2019-10-10T13:00:00-04:00 Palmer Commons Life Sciences Institute (LSI) Lecture / Discussion LSI Seminar Series
EEB Thursday Seminar: Inferring the evolutionary timescale of vascular plant evolution (October 10, 2019 4:00pm) https://events.umich.edu/event/65471 65471-16603598@events.umich.edu Event Begins: Thursday, October 10, 2019 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Methods for inferring divergence times from molecular phylogenies are highly contentious. The majority of the applications of the classic "node-based" approach rely heavily on individual researchers' implicit assumptions about patterns of morphological evolution and the fossilization process. The application of these methods to understanding the evolution of vascular plants has been particularly controversial, yielding divergence time estimates often seen as incompatible with the fossil record. However, "total-evidence dating" (TED) methodologies offer the opportunity to overcome the difficulties inherent in the traditional node-based approaches, allowing for the simultaneous inference of the phylogenetic relationships of extant and extinct vascular plants, their divergence times, and their patterns of morphological evolution. As part of a broader project to infer the timeline of vascular plant evolution, I will discuss results of the application of TED approaches to the Marattiales, a eusporangiate fern lineage with a deep fossil record (Marattiales taxa were dominant components of Carboniferous coal swamps), and close with comments on the challenges in implementing TED analyses, and in particular, in applying defensible models of morphological evolution.

View YouTube video of seminar: https://youtu.be/PEdhz9BuJbU

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Workshop / Seminar Fri, 10 Apr 2020 14:15:36 -0400 2019-10-10T16:00:00-04:00 2019-10-10T17:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Vascular plant evolution painting. Credit Tom Phillips
Revealing the chemistry in quantum chemistry: from diatomics to proton coupled electron transfer in enzymes (October 10, 2019 4:00pm) https://events.umich.edu/event/65047 65047-16509307@events.umich.edu Event Begins: Thursday, October 10, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

With quantum chemistry nowadays most physical properties of molecules can be easily and (often) accurately calculated—for example, DFT calculations of molecular structure, reaction mechanisms, and reaction energetics have become routine complements to organic chemistry. However, the techniques behind these calculations afford no easy way of "making sense" of the computed quantities, like orbitals and wave functions. Additionally, many central empirical concepts of chemistry, including concepts as basic as partial charges, bond orders, or even covalent bonds themselves, have no consensus physical definition.

We here argue that, once we properly define what is an "atomic orbital" in a molecule, quantities representing most other empirical concepts can be straight-forwardly derived from simple physical arguments, and then easily calculated. In this sense, we show how our Intrinsic Atomic Orbital (IAO) technique gives rise to partial charges and bond orders, and to bond orbitals, which represent the electron pairs of Lewis structures (σ- and π-bonds). Even curly-arrow reaction mechanisms can be readily derived!

Based on selected examples of both us and others, we how IAOs allow the analysis of bonding in novel and exotic chemical species, and how the method played a key role in understanding metal-catalyzed reaction mechanisms.
Gerald Knizia (Penn State)

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Other Thu, 10 Oct 2019 18:15:45 -0400 2019-10-10T16:00:00-04:00 2019-10-10T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Graduate student panel (October 10, 2019 5:00pm) https://events.umich.edu/event/67688 67688-16918010@events.umich.edu Event Begins: Thursday, October 10, 2019 5:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

As part of Biology Week, graduate students from the Department of Molecular, Cellular and Developmental Biology and the Department of Ecology and Evolutionary Biology are holding a panel on applying to graduate school and general advice on handling the first couple years of grad school.

They will answer questions on the graduate school application process and on the transition from undergraduate to graduate level research. The panel will be followed by a make-your-own-ice cream mixer.

Image credit: Tao Wan

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Lecture / Discussion Thu, 26 Sep 2019 15:57:20 -0400 2019-10-10T17:00:00-04:00 2019-10-10T19:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Lecture / Discussion Two pronghorns walking past in a beautiful setting at Yellowstone National Park
U-M Structure Seminar: Kazuhiro Yamada, Ph.D. (October 11, 2019 10:00am) https://events.umich.edu/event/65696 65696-16629900@events.umich.edu Event Begins: Friday, October 11, 2019 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

Kazuhiro Yamada, Ph.D.
Research Lab Specialist Associate, Markos Koutmos Lab
University of Michigan

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Lecture / Discussion Fri, 23 Aug 2019 14:34:31 -0400 2019-10-11T10:00:00-04:00 2019-10-11T11:00:00-04:00 Life Sciences Institute U-M Structural Biology Lecture / Discussion Life Sciences Institute
Biophysics Talk Title: TBD (October 11, 2019 12:00pm) https://events.umich.edu/event/64272 64272-16274482@events.umich.edu Event Begins: Friday, October 11, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: TBD

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Workshop / Seminar Wed, 10 Jul 2019 09:38:39 -0400 2019-10-11T12:00:00-04:00 2019-10-11T13:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
CSIEUM -Seminar TBD (October 11, 2019 12:00pm) https://events.umich.edu/event/65048 65048-16509308@events.umich.edu Event Begins: Friday, October 11, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry
















Jack Barbera

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Other Mon, 09 Sep 2019 12:15:32 -0400 2019-10-11T12:00:00-04:00 2019-10-11T13:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
MCDB Seminar: Temperature Sensing and Preference in Drosophila (October 11, 2019 12:00pm) https://events.umich.edu/event/67350 67350-16839923@events.umich.edu Event Begins: Friday, October 11, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Monica Dus

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Workshop / Seminar Tue, 17 Sep 2019 16:11:36 -0400 2019-10-11T12:00:00-04:00 2019-10-11T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar cartoon of large Drosophila fly and city in flames
Fall Seminar Series: The landscape of benign breast and breast cancer (October 11, 2019 2:00pm) https://events.umich.edu/event/66637 66637-16770114@events.umich.edu Event Begins: Friday, October 11, 2019 2:00pm
Location: School of Public Health Bldg I and Crossroads and Tower
Organized By: Biosciences Initiative

Dr. Melissa Troester’s laboratory studies breast cancer and benign breast disease using genomic, molecular pathology, and epidemiological approaches. Much of Dr. Troester’s research focus has been on understanding interactions between the environment and breast genomics.

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Workshop / Seminar Mon, 09 Sep 2019 12:06:33 -0400 2019-10-11T14:00:00-04:00 2019-10-11T15:00:00-04:00 School of Public Health Bldg I and Crossroads and Tower Biosciences Initiative Workshop / Seminar School of Public Health Bldg I and Crossroads and Tower
BME Talk: David Nordsletten (October 11, 2019 3:00pm) https://events.umich.edu/event/68252 68252-17035297@events.umich.edu Event Begins: Friday, October 11, 2019 3:00pm
Location: East Hall
Organized By: Biomedical Engineering

The human heart is a complex electromechanical pump, translating electrophysiological stimulation into tissue contraction and the ejection of blood from its chambers to drive cardiovascular blood flow. Despite being incredibly adaptable and robust, the human heart can experience a myriad of maladies leading to disruption and dysfunction. Core to cardiac physiology, and pathophysiology, is the efficient interaction between solid tissue and blood, translating mechanical work into blood flow. Understanding this interaction, principles of fluid mechanics, turbulence and fluid-structure interaction provide a core foundation. From recent work on image-based estimation of pressure loss, to analytic solutions and computational methods for fluid-structure interaction, to multigrid-in-time, this talk will explore some of the mathematical techniques useful for evaluating the behavior of blood and its impact on the heart.

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Lecture / Discussion Thu, 10 Oct 2019 11:09:57 -0400 2019-10-11T15:00:00-04:00 2019-10-11T15:50:00-04:00 East Hall Biomedical Engineering Lecture / Discussion BME Logo
Biologist-for-a-Day Outreach Event (October 12, 2019 12:00pm) https://events.umich.edu/event/67966 67966-16975354@events.umich.edu Event Begins: Saturday, October 12, 2019 12:00pm
Location: Biological Sciences Building
Organized By: MCDB Graduate Student Council - MCDB-GSC

Graduate and undergraduate science students are holding an outreach event at BSB. Hands-on activities will demonstrate scientific concepts to families visiting campus. If you are a student and would like to be a part of this or future science outreach events, please contact the Biology Outreach Team (BOT.Contact@umich.edu).

Date: Sunday, November 24th
Time: 1pm - 3pm
Place: BSB, First Floor

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Community Service Mon, 28 Oct 2019 11:00:46 -0400 2019-10-12T12:00:00-04:00 2019-10-12T15:00:00-04:00 Biological Sciences Building MCDB Graduate Student Council - MCDB-GSC Community Service An activity station from a biology outreach event in August
LSI Diversity Summit Lecture: Aseem Z. Ansari, Ph.D. (October 14, 2019 12:00pm) https://events.umich.edu/event/68027 68027-16986090@events.umich.edu Event Begins: Monday, October 14, 2019 12:00pm
Location: Palmer Commons
Organized By: Life Sciences Institute (LSI)

The Ansari group has pioneered the development of synthetic transcription factors (SynTFs) to control desired gene regulatory networks and guide cell fate choices. In a sense, SynTFs could be viewed as chemical counterparts of the much larger CRISPR-Cas based gene regulators.

Integrating structure-guided design and chemical genomics, the Ansari group created an exciting class of molecules that can rewire epigenetic states at targeted genomic loci. SynTFs designed to reverse repressive epigenetic marks have restored expression of genes whose deficiency causes incurable neuronal diseases such as Friedreich’s ataxia, a progressive neurodegenerative disorder that has no effective therapy. More broadly, SynTFs can be precision-tailored to understand and remedy a wide array of human diseases.

About the Speaker:
Aseem Z. Ansari is the R. J. Ulrich Chair of Chemical Biology and Therapeutics at St. Jude Children’s Research Hospital and the founder of the Khorana and Bose Programs.

Aseem began his scientific career as a summer intern in the laboratory of Obaid Siddiqi at Tata Institute of Fundamental Research (TIFR) in Bombay. That experience led him to graduate studies in Chemical Biology at Northwestern University. Aseem completed his training postdoctoral training as a Helen Hay Whitney Fellow at Harvard University and the Massachusetts Institute of Technology. He was also a resident tutor at the Winthrop House and member of the Board of Tutors in Biochemical Sciences at Harvard. The Ansari Lab works on devising synthetic gene switches that control the fate of human embryonic stem cells and correct gene regulatory networks in neurodegenerative diseases.

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Lecture / Discussion Fri, 04 Oct 2019 13:50:39 -0400 2019-10-14T12:00:00-04:00 2019-10-14T13:00:00-04:00 Palmer Commons Life Sciences Institute (LSI) Lecture / Discussion Aseem Z. Ansari, Ph.D.
Radical Initiation in the Radical SAM Superfamily (October 14, 2019 4:00pm) https://events.umich.edu/event/63729 63729-15835122@events.umich.edu Event Begins: Monday, October 14, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Radical SAM enzymes utilize a [4Fe-4S] cluster and S-adenosyl-L-methionine (SAM) to initiate diverse radical-based reactions throughout all kingdoms of life. Despite the limited sequence similarity and vastly divergent reactions catalyzed, the radical SAM enzymes appear to employ a common mechanism for initiation of radical chemistry, in which a reduced [4Fe-4S]+ cluster provides the electron needed for the reductive cleavage of SAM. The amino and carboxylate groups of SAM bind to the unique iron of the catalytic [4Fe-4S] cluster, placing the sulfonium of SAM in close proximity to the cluster. Surprising recent results have shown that the initial enzymatic cleavage of SAM generates an organometallic intermediate prior to liberation of 5’-dAdo•, which initiates radical chemistry on substrate. This organometallic intermediate, denoted , has a 5’-deoxyadenosyl moiety directly bound to the unique iron of the [4Fe-4S] cluster via the 5’-C, giving a structure that is directly analogous to Co-(5’-C) bond of the organometallic cofactor adenosylcobalamin. Our observation that this intermediate  is formed throughout the superfamily suggests that this is a key intermediate in initiating radical SAM reactions, and further indicates that organometallic chemistry is much more broadly relevant in biology than previously thought. We have also discovered novel photochemistry in radical SAM enzymes, wherein photoinduced electron transfer generates SAM-derived radicals, providing new insights into fundamental radical initiation chemistry.








Joan Broderick (Montana State University)

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Other Mon, 14 Oct 2019 18:15:41 -0400 2019-10-14T16:00:00-04:00 2019-10-14T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
RNA Innovation Seminar, Ailong Ke, Cornell University (October 14, 2019 4:00pm) https://events.umich.edu/event/65137 65137-16539448@events.umich.edu Event Begins: Monday, October 14, 2019 4:00pm
Location: Palmer Commons
Organized By: Center for RNA Biomedicine

Ailong Ke PhD, Professor, Department of Molecular Biology and Genetics, Cornell University

Abstract: CRISPR-Cas serves as an RNA-based adaptive immunity system in prokaryotes. The diverse CRISPR systems can be categorized into two major classes and multiple types therein. Type I CRISPR-Cas (or CRISPR-Cas3) belongs to Class 1 and is the most prevalent CRISPR system found in nature. It features a sequential target-searching and degradation process. First, the target-searching complex Cascade (CRISPR associated complex for antiviral defense) uses its guide RNA to find the complementary dsDNA target, and opens a special structure called R-loop at the target site. Its helicase-nuclease fusion enzyme Cas3 is then specifically recruited to the Cascade/R-loop site to processively degrade long-stretches of double-stranded DNA nearby. I will give a comprehensive explanation of CRISPR-Cas3 based interference mechanism, based on the high-resolution biochemistry and structural biology work from my lab. I will further explain CRISPR-Cas3 based genome editing applications, and give perspectives on its therapeutic potential.

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Lecture / Discussion Wed, 25 Sep 2019 10:55:45 -0400 2019-10-14T16:00:00-04:00 2019-10-14T17:00:00-04:00 Palmer Commons Center for RNA Biomedicine Lecture / Discussion flyer
Cholesterol and Phospholipis Metabolism in Physiology and Disease- Annual William E.M. Lands Lectureship in Biological Chemistry (October 15, 2019 12:00pm) https://events.umich.edu/event/67920 67920-16966900@events.umich.edu Event Begins: Tuesday, October 15, 2019 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Peter Tontonoz will deliver the 15th annual William E.M. Lands Lecture on the Biochemical Basis for the Physiology of Essential Nutrients. Dr. Tontonoz is a Professor of Pathology and Laboratory Medicine at the University of California, Los Angeles.

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Lecture / Discussion Wed, 02 Oct 2019 10:37:58 -0400 2019-10-15T12:00:00-04:00 2019-10-15T13:00:00-04:00 Medical Science Unit II Biological Chemistry Lecture / Discussion Tontonoz
NO EEB Tuesday Lunch Seminar today (October 15, 2019 12:00pm) https://events.umich.edu/event/65000 65000-16501299@events.umich.edu Event Begins: Tuesday, October 15, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Have a good fall study break. See you next week!

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Workshop / Seminar Thu, 05 Sep 2019 16:32:06 -0400 2019-10-15T12:00:00-04:00 2019-10-15T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Biological Sciences Building background, UM EEB logo and text reading EEB Tuesday Lunch Seminars
TBA (October 15, 2019 12:00pm) https://events.umich.edu/event/67184 67184-16807427@events.umich.edu Event Begins: Tuesday, October 15, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Bradley Carrow (Princeton University)

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Other Thu, 19 Sep 2019 06:15:57 -0400 2019-10-15T12:00:00-04:00 2019-10-15T13:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
How Cell Communication Drives Tissue Form and Function (October 16, 2019 9:30am) https://events.umich.edu/event/67426 67426-16849184@events.umich.edu Event Begins: Wednesday, October 16, 2019 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

2019 Cell & Developmental Biology Seminar Series

Hosted By: Pierre Coulombe, PhD & Kristen Verhey, PhD

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Lecture / Discussion Wed, 18 Sep 2019 15:33:41 -0400 2019-10-16T09:30:00-04:00 2019-10-16T10:30:00-04:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion CDB Seminar - Green
Synthesis and Biological Studies of GPI Anchors and GPI-Anchored Proteins (October 16, 2019 12:00pm) https://events.umich.edu/event/65049 65049-16509309@events.umich.edu Event Begins: Wednesday, October 16, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Glycosylphosphatidylinositol (GPI) attachment to the protein C-terminus is one of the most common and important posttranslational modifications, and many surface proteins are anchored to the cell membrane via GPIs to play an important role in various biological and pathological events. To explore these events, it is necessary to obtain GPIs and GPI-anchored proteins in homogeneous and structurally well-defined forms, which represents a great challenge. Our research program aims at establishing proper methods to access natural GPIs, GPI-linked peptides/glycopeptides/proteins, and related derivatives and applying them to the study of GPI biology. Accordingly, a series of new chemical and chemoenzymatic strategies have been developed for GPI and GPI conjugate synthesis, and the synthetic molecules have been used to investigate relevant biological problems, such as GPI-cell membrane interactions, GPI-bacterial toxin interactions, and GPI-anchored proteomics analysis.










Zhongwu Guo (University of Florida)

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Other Wed, 16 Oct 2019 18:15:54 -0400 2019-10-16T12:00:00-04:00 2019-10-16T13:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Department of Computational Medicine & Bioinformatics Weekly Seminar (October 16, 2019 4:00pm) https://events.umich.edu/event/68138 68138-17011980@events.umich.edu Event Begins: Wednesday, October 16, 2019 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Talk Title: "3D genome structure as a tool to understand the impact of somatic and germline sequence variants"

Abstract: The 3-dimensional organization of DNA inside of the nucleus impacts a variety of cellular processes, including gene regulation. Furthermore, it is apparent that somatic structural variants that affect how chromatin is organized in 3D can have a major impact on gene regulation and human disease. However, such structural variants in the context of cancer genomes are abundant, and predicting the consequence of any individual somatic mutation on 3D genome structure and gene expression is challenging. In addition, we are severely limited with regard to tools that can be used to study 3D folding of the genome in vivo in actual human tumor or tissue samples. Our lab has developed several approaches to address these challenges. We have taken a pan-cancer approach to identify loci in the genome that are affected by structural variants that alter 3D genome structure, and we have identified numerous loci with recurrent 3D genome altering mutations. We have also used genome engineering to create novel structural variants to better understand what types of mutations are actually capable of altering 3D genome structure and gene regulation. Finally, we have also developed novel tools to study 3D genome structure in vivo in complex tissue samples. We believe that these approaches will be critical for improving our understanding of how non-coding sequence variants can affect 3D genome structure and gene regulation, with the ultimate goal of understanding how these events affect human physiology.

3:45 pm - Light Refreshments Served
4:00 pm - Lecture

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Lecture / Discussion Mon, 07 Oct 2019 16:39:45 -0400 2019-10-16T16:00:00-04:00 2019-10-16T17:00:00-04:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
Donuts in the Dude with ISD (October 17, 2019 11:00am) https://events.umich.edu/event/66628 66628-16770206@events.umich.edu Event Begins: Thursday, October 17, 2019 11:00am
Location: Duderstadt Center
Organized By: Integrative Systems + Design

Stop by, grab a Washtenaw Dairy Donut, and learn more about Integrative Systems + Design!

Interested in vehicle electrification, advances in fuel technologies, cleaner energy, or a host of other challenges? ISD is the place for innovative graduate programs that prepare you to become a leader in your field.

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Other Mon, 09 Sep 2019 14:20:29 -0400 2019-10-17T11:00:00-04:00 2019-10-17T12:30:00-04:00 Duderstadt Center Integrative Systems + Design Other Duderstadt Center
Complex Systems/MICDE Seminar | Numerical Simulations of Turbulence in Heated Fluids (October 17, 2019 11:30am) https://events.umich.edu/event/67601 67601-16900791@events.umich.edu Event Begins: Thursday, October 17, 2019 11:30am
Location: Weiser Hall
Organized By: The Center for the Study of Complex Systems

This seminar is co-sponsored by the Center for the Study of Complex Systems and the Michigan Institute for Computational Discovery and Engineering

Abstract:
Turbulent systems are all around us, from waves crashing on our beaches, to smoke rising from the fires in our mountains, to the air that can disrupt our smooth airline flights. But, turbulent systems are not well understood. Rayleigh-Benard Convection is a more simplified system which captures some of the key features of turbulence, including thermal plumes, thin boundary layers and large-scale flow. In Rayleigh-Benard convection, an enclosed fluid is bounded by horizontal parallel plates kept at a constant temperature difference. Results from numerical simulations of the equations which describe Rayleigh-Benard convection will be discussed and compared to experimental and theoretical results. These include flows in air and liquid metals in confined containers in addition to more horizontally extended systems.

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Workshop / Seminar Fri, 11 Oct 2019 11:54:18 -0400 2019-10-17T11:30:00-04:00 2019-10-17T13:00:00-04:00 Weiser Hall The Center for the Study of Complex Systems Workshop / Seminar Janet Scheel
Fall Health Communicators Forum (October 17, 2019 3:00pm) https://events.umich.edu/event/67814 67814-16952011@events.umich.edu Event Begins: Thursday, October 17, 2019 3:00pm
Location: North Campus Research Complex Building 10
Organized By: Center for Interprofessional Education

Speakers giving short presentations include:

Kelly B. Sexton, Ph.D., Associate Vice President for Research, Technology Transfer and Innovation

Chris Fick, Ph.D., Senior Director, Business Engagement Center

April Pepperdine, Conflict of Interest Manager, U-M Office of Research

June Anne Insco, Conflict of Interest Manager, U-M Medical
School

Rsvp at https://doodle.com/poll/87zzk4u9txbp2m8u

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Lecture / Discussion Mon, 30 Sep 2019 14:57:47 -0400 2019-10-17T15:00:00-04:00 2019-10-17T16:30:00-04:00 North Campus Research Complex Building 10 Center for Interprofessional Education Lecture / Discussion science translation and communication
EEB Thursday Seminar: Who plants mate with, how they do it, and why it matters (October 17, 2019 4:00pm) https://events.umich.edu/event/65473 65473-16603599@events.umich.edu Event Begins: Thursday, October 17, 2019 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Biological diversity at all scales—ranging from patterns of nucleotide variation across chromosomes to phenotypic variation found within and between species—is shaped by the events of birth, movement, mating, and death that play out across populations for generations. Throughout each of these processes, the question of mate choice is crucially important. For example, every instance of mating with oneself (self-fertilization or selfing) halves an individual’s genomic variation, exposing rare recessive mutations. At the other end of the spectrum, mating with another species may either reduce fitness via hybrid incompatibilities or introduce novel, potentially adaptive, genetic variation. I present my research, which combines theory, and data to investigate both the evolutionary implications of these mating decisions (e.g. their effects on the species range, the nature of genetic variation, genomic architecture etc) and when and how such traits can (or cannot) evolve.

View YouTube video of seminar: https://youtu.be/w7GGngxIysU

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Workshop / Seminar Thu, 02 Apr 2020 12:53:20 -0400 2019-10-17T16:00:00-04:00 2019-10-17T17:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Yaniv Brandvain talk
Membrane Interactions and Amyloid Formation of α-Synuclein (October 17, 2019 4:00pm) https://events.umich.edu/event/64839 64839-16460976@events.umich.edu Event Begins: Thursday, October 17, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Synuclein is most well-known for its involvement in the etiology of Parkinson’s disease where α-synuclein amyloid fibrils are found in Lewy bodies, a histopathological hallmark. Membrane association of α-synuclein is associated with its biological function and implicated in pathogenesis. Upon membrane association, α-synuclein adopts an α-helical structure, whereas in solution, the protein is disordered. In a disease state, β-sheet rich, amyloid fibrils of aggregated α-synuclein accumulate in the cytosol. In this work, we aim to understand how amyloid formation is influenced by lipids and in turn, how the protein aggregation process may lead to deleterious α-synuclein interactions with membranes. We are especially interested in the ability of α-synuclein to sense and generate membrane curvature, which could have both functional and dysfunctional consequences. Building upon the fundamental understanding of α-synuclein–lipid interactions, we are developing Raman microspectroscopy to study protein conformational dynamics and aggregation in cells. This powerful approach reports on protein secondary structural changes, allowing us to identify whether the protein has adopted a β-sheet rich form, indicative of amyloid structure, as a function of its spatial location. In this talk, I will present our latest results on (1) membrane fluidity and curvature sensing by α-synuclein, (2) Raman spectroscopic characterization of α-synuclein amyloid formation, and (3) cellular studies of α-synuclein. Through our work, we are developing a chemical understanding in how specific biomolecular interactions and cellular environments modulate α-synuclein structure and aggregation propensity.
Jennifer Lee (NIH)

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Other Thu, 17 Oct 2019 18:15:50 -0400 2019-10-17T16:00:00-04:00 2019-10-17T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
U-M Structure Seminar: Debashish Sahu, Ph.D. (October 18, 2019 10:00am) https://events.umich.edu/event/65698 65698-16629904@events.umich.edu Event Begins: Friday, October 18, 2019 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

BioNMR Director
University of Michigan
https://bionmrcore.umich.edu/

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Lecture / Discussion Fri, 23 Aug 2019 14:54:45 -0400 2019-10-18T10:00:00-04:00 2019-10-18T11:00:00-04:00 Life Sciences Institute U-M Structural Biology Lecture / Discussion Life Sciences Institute
Manufacturing Seminar Series (October 18, 2019 11:00am) https://events.umich.edu/event/68231 68231-17028948@events.umich.edu Event Begins: Friday, October 18, 2019 11:00am
Location: Chrysler Center
Organized By: Integrative Systems + Design

Join us Friday, October 18, 2019 from 11:00 am-12:00 pm in Chrysler Center, Room 151 (2121 Bonisteel Blvd, Ann Arbor) for our Manufacturing Seminar Series Speaker, with Dr. Yu-Ning Liu. Dr. Yu-Ning Liu is the Technical Leader in Operations Analytics of Ford Global Data Insights & Analytics (GDI&A).

In this presentation, Dr. Yu-Ning Liu will briefly introduce GDI&A, its mission, vision, and the journey since its debut in 2015. He will then provide an overview of selected projects in the Manufacturing and Supply Chain area to demonstrate how data analytics has fundamentally changed this American icon.

RSVP here: https://docs.google.com/forms/d/e/1FAIpQLSeVa_mhqxJehyDy0_VJQocIU-PGmkBbFXRL0w5zgZk-aokmcw/viewform

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Workshop / Seminar Wed, 09 Oct 2019 15:23:35 -0400 2019-10-18T11:00:00-04:00 2019-10-18T12:00:00-04:00 Chrysler Center Integrative Systems + Design Workshop / Seminar MFG Seminar
Biophysics Talk Title: TBD (October 18, 2019 12:00pm) https://events.umich.edu/event/64273 64273-16274483@events.umich.edu Event Begins: Friday, October 18, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: TBD

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Workshop / Seminar Wed, 10 Jul 2019 09:39:01 -0400 2019-10-18T12:00:00-04:00 2019-10-18T13:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
MCDB Seminar: Monoterpene Volatile Biosynthesis in Rose Scented Geranium (October 18, 2019 12:00pm) https://events.umich.edu/event/67356 67356-16839924@events.umich.edu Event Begins: Friday, October 18, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Eran Pichersky

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Workshop / Seminar Tue, 17 Sep 2019 16:19:55 -0400 2019-10-18T12:00:00-04:00 2019-10-18T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Glandular trichomes Pelargonium graveolens
Precision Health Analytics Platform Roadshow (October 18, 2019 12:00pm) https://events.umich.edu/event/66954 66954-16787746@events.umich.edu Event Begins: Friday, October 18, 2019 12:00pm
Location: North Campus Research Complex Building 16
Organized By: Precision Health

Are you a health researcher looking for genetic and clinical data, or do you need assistance in data analysis?

Precision Health’s new Analytics Platform is a suite of tools, services, and datasets available to researchers across campus--resources previously available only to Michigan Medicine faculty and other level-two password holders. The platform provides campus-wide access to research tools such as DataDirect and services such as consultation with scientific facilitators.

Attend a roadshow to learn how to access the platform and what you can do with it:

• Perform cohort discovery on a database of 4M+ patients
• Query a de-identified, structured dataset of ~60K patients
• Submit queries through the self-serve tool DataDirect
• Access output via a secure, HIPAA-compliant environment
• Request access to linked genetic data (with IRB approval)

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Presentation Wed, 18 Sep 2019 12:20:05 -0400 2019-10-18T12:00:00-04:00 2019-10-18T13:00:00-04:00 North Campus Research Complex Building 16 Precision Health Presentation DataDirect
2019 Borer Lecture: Laurie Goodyear, PhD (October 18, 2019 2:30pm) https://events.umich.edu/event/65756 65756-16654032@events.umich.edu Event Begins: Friday, October 18, 2019 2:30pm
Location: Brehm Tower
Organized By: School of Kinesiology

This year's Katarina T. Borer Lectureship in Exercise Endocrinology and Metabolism guest speaker is Laurie Goodyear, PhD, Professor of Medicine and Section Head, Joslin Diabetes Center, at Harvard Medical School. She will present "Why Moms and Dads Should Exercise: Molecular Discoveries of the Beneficial Effects of Parental Exercise on Offspring Health."

Friday, October 18, at 2:30pm
Brehm Tower, Oliphant-Marshall Auditorium (1st floor)
1000 Wall St., Ann Arbor, MI 48109
Reception to follow

RSVP at http://myumi.ch/errk2!

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Lecture / Discussion Mon, 26 Aug 2019 16:54:36 -0400 2019-10-18T14:30:00-04:00 2019-10-18T17:30:00-04:00 Brehm Tower School of Kinesiology Lecture / Discussion Borer Lectureship: Laurie Goodyear, PhD
CALCIUM - Seminar TBD (October 18, 2019 4:00pm) https://events.umich.edu/event/65521 65521-16607706@events.umich.edu Event Begins: Friday, October 18, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Kate Crawford Biberdorf (TSMU)

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Other Fri, 18 Oct 2019 18:15:57 -0400 2019-10-18T16:00:00-04:00 2019-10-18T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
SUB-MICRON X-RAY FLUORESCENCE IMAGING OF BIOLOGICAL SAMPLES AT 2-ID-E AT THE ADVANCED PHOTON SOURCE (October 18, 2019 4:00pm) https://events.umich.edu/event/67951 67951-16971138@events.umich.edu Event Begins: Friday, October 18, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Oleg Antipova (APS)

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Other Fri, 18 Oct 2019 18:15:56 -0400 2019-10-18T16:00:00-04:00 2019-10-18T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Complex Systems - Quant. Bio Seminar | Stochastic Turing patterns in oceans, brains and biofilms (October 21, 2019 12:00pm) https://events.umich.edu/event/68409 68409-17080044@events.umich.edu Event Begins: Monday, October 21, 2019 12:00pm
Location: West Hall
Organized By: The Center for the Study of Complex Systems

A special seminar co-hosted by Quantitative Bio. Seminars & CSCS. The first of two talks Professor Goldenfeld will be giving in two days at the University of Michigan

ABSTRACT
Why are the patterns of plankton in the ocean so patchy? Why do frequently described geometrical hallucinations tend to fall into one of four different classes of pattern? Why don't we see hallucinations all the time? And why do populations in ecosystems tend to have noisy cycles in abundance? This talk explains how these phenomena all arise from the discreteness of the underlying entities, be they the on-off states of neurons or the numbers of bacteria in a fluid volume of ocean, or the number of signaling molecules in a biofilm. I explain how tools from statistical mechanics can yield insights into these phenomena, and report on a range of studies that include the operation of the primate visual cortex, the behavior of signalling molecules in a forward-engineered synthetic biofilm, and the fluctuating patterns and populations of marine organisms.

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Workshop / Seminar Tue, 15 Oct 2019 15:45:09 -0400 2019-10-21T12:00:00-04:00 2019-10-21T13:00:00-04:00 West Hall The Center for the Study of Complex Systems Workshop / Seminar Swanlund Professor of Physics Nigel Goldenfeld
Energy Conversion and Storage: Novel Materials and Operando Methods (October 21, 2019 4:00pm) https://events.umich.edu/event/63991 63991-16059321@events.umich.edu Event Begins: Monday, October 21, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

This presentation will deal with the development of new materials and operando methods for energy conversion and storage with emphasis on fuel cells and battery materials and technologies. The presentation will begin with a brief overview of the methods employed. Particular emphasis will be placed on the use of X-ray diffraction (XRD), X-ray absorption spectroscopy (XAS) X-ray microscopy and tomography and transmission electron microscopy (TEM) under active potential control. The utility of these methods will be illustrated by selected examples including electrocatalysts for the oxygen reduction reaction (ORR), hydrogen oxidation reaction (HOR) and spectroscopic studies of Li/S batteries and Li metal deposition and dendritic growth. The presentation will conclude with an assessment of future directions.
Hector Abruña (Cornell University)

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Other Mon, 21 Oct 2019 18:15:47 -0400 2019-10-21T16:00:00-04:00 2019-10-21T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
RNA Innovation Seminar, Ruslan Afasizhev, Boston University Medical Campus (October 21, 2019 4:00pm) https://events.umich.edu/event/65138 65138-16539449@events.umich.edu Event Begins: Monday, October 21, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Ruslan Afasizhev, PhD, Professor, Molecular & Cell Biology, Boston University Medical Campus

Abstract: Parasitic protist Trypanosoma brucei causes African human and animal trypanosomiasis, a spectrum of diseases affecting the population and economy in sub-Saharan Africa. These digenetic hemoflagellates belong to Kinetoplastea, a taxonomic class distinguished by possession of a kinetoplast. This nucleoprotein body contains mitochondrial DNA of two kinds: ~25 maxicircles (each ~23kb) encoding ribosomal RNAs, two guide RNA (gRNAs), ribosomal proteins and subunits of respiratory complexes, and approximately 5000 of ~1kb minicircles bearing the majority of gRNA genes. Relaxed maxicircles and minicircles are interlinked and packed into a dense disc-shaped network by association with histone-like proteins. Both maxicircle and minicircle genomes are transcribed by a phage-like RNA polymerase from multiple promoters into 3′-extended precursors which undergo 3′-5′ exonucleolytic trimming. To function in mitochondrial translation, pre-mRNAs must further proceed through 3′ adenylation, and often gRNA-directed uridine insertion/deletion editing, and 3′ A/U-tailing. Ribosomal and guide RNAs are typically 3′ uridylated. Historically, the fascinating phenomenon of RNA editing has attracted major research efforts, but more recent developments provided insights into pre- and post-edited processing events and identified key players in transforming primary precursors into functional RNAs and regulating their turnover. I will present a forward-looking model that integrates known modalities of mitochondrial RNA metabolism.

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Lecture / Discussion Wed, 25 Sep 2019 10:59:39 -0400 2019-10-21T16:00:00-04:00 2019-10-21T17:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion flyer
"The Causes and Consequences of Human Obesity" (October 22, 2019 10:00am) https://events.umich.edu/event/68210 68210-17026817@events.umich.edu Event Begins: Tuesday, October 22, 2019 10:00am
Location: Taubman Biomedical Science Research Building
Organized By: A. Alfred Taubman Medical Research Institute

Dr. O'Rahilly, considered the preemiment obesity researcher of this generation, is a clinician-scientist at the University of Cambridge in the United Kingdom. He will receive the Taubman Prize for his contribution to new understanding of obesity and metabolic diseases.
The Taubman Institute symposium will kick off with a poster session and continental breakfast at 8:30 a.m. in the BSRB lobby; Dr. O'Rahilly will be awarded the Taubman Prize aware and deliver his keynote from 10 a.m. to noon in the Kahn Auditorium at the BSRB.
All are welcome, no registration is required.

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Lecture / Discussion Wed, 09 Oct 2019 11:37:17 -0400 2019-10-22T10:00:00-04:00 2019-10-22T12:00:00-04:00 Taubman Biomedical Science Research Building A. Alfred Taubman Medical Research Institute Lecture / Discussion Professor Sir Stephen O'Rahilly, 2019 Taubman Prize recipient
Complex Systems Seminar | (Soft) Matter of Life and Death: Biophysical Consequences of Death and Reproduction in Bacterial Biofilms (October 22, 2019 11:30am) https://events.umich.edu/event/68311 68311-17045990@events.umich.edu Event Begins: Tuesday, October 22, 2019 11:30am
Location: Weiser Hall
Organized By: The Center for the Study of Complex Systems

Biofilms are surface attached communities formed by bacteria and other microbes. Biofilms that form in nature typically feature different taxa, species, and multiple strains of the same species. These cells compete for nutrients and space. Due to the broad prevalence of biofilms, bacteria have evolved various competitive strategies, many of which are antagonistic. This includes a number of complex toxin delivery systems, which kill competitors but not kin. Because biofilms are densely packed, cell death and reproduction hold emergent mechanical consequences. When a cell dies and lyses, the biofilm may partially ‘cave-in;’ when a cell reproduces, it pushes other cells out of its way. This deadly competition creates a feedback loop. Death and reproduction modify biofilm structure; structural changes impact subsequent death and reproduction. In this talk, I will explore the intertwined relationship between intercellular killing and biofilm materials properties, explaining both the new physics that arises and its biological impact.

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Workshop / Seminar Fri, 11 Oct 2019 14:48:50 -0400 2019-10-22T11:30:00-04:00 2019-10-22T13:00:00-04:00 Weiser Hall The Center for the Study of Complex Systems Workshop / Seminar Peter Yunker
BIONIC Lunch: Artificial Intelligence in Medicine (October 22, 2019 12:00pm) https://events.umich.edu/event/63777 63777-15873595@events.umich.edu Event Begins: Tuesday, October 22, 2019 12:00pm
Location: North Campus Research Complex Building 10
Organized By: The Bioethics Discussion Group

Join us for a lunchtime discussion as we assess the computational engines assessing us.

Please RSVP: https://forms.gle/5t6UjXWNA1VSW4fr9

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Lecture / Discussion Mon, 23 Sep 2019 14:00:08 -0400 2019-10-22T12:00:00-04:00 2019-10-22T13:30:00-04:00 North Campus Research Complex Building 10 The Bioethics Discussion Group Lecture / Discussion Artificial Intelligence in Medicine
EEB Tuesday Lunch Seminar: Phenotypic and genotypic changes in the evolution of antibiotic resistance after decades of relaxed selection (October 22, 2019 12:00pm) https://events.umich.edu/event/65001 65001-16501300@events.umich.edu Event Begins: Tuesday, October 22, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Please join us for our weekly brown bag lunch seminar.

Abstract
Populations often encounter environmental changes that remove selection for the maintenance of certain phenotypic traits. The resulting decay of these traits under relaxed selection reduces an organism’s fitness in its prior environment. However, how these traits subsequently evolve upon restoration of selection is not well-understood. We addressed this question using Escherichia coli strains from the long-term evolution experiment (LTEE) that have been independently evolving for multiple decades in the absence of antibiotics. We confirmed that these derived strains have typically become more sensitive to various antibiotics during this time. We then asked how readily the bacteria could overcome these losses of intrinsic resistance through subsequent evolution when challenged with these same drugs. In our study, we focused on the role that genetic background plays in this process, with attention to the tension between evolutionary repeatability and contingency. We found that idiosyncratic responses in evolvability dominated over trends of diminishing returns, such that the potential to evolve increased resistance was hampered on some derived genetic backgrounds. We further subjected a time-series of clones from one LTEE population to tetracycline and showed that evolutionary constraint occurred early in its history. Taken together, our results indicate that the evolution and diversification of a single species in an antibiotic-free environment can render resistance evolution unpredictable, even for closely related strains. Current work is now centered on characterizing the genomic changes underlying resistance to address whether the same genes are the focus of selection when strains have evolved for decades in the absence of antibiotics.

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Workshop / Seminar Tue, 15 Oct 2019 11:47:45 -0400 2019-10-22T12:00:00-04:00 2019-10-22T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar petri dishes with colorful filter effect
Mallosteric Misfolding and Rhomboidal Retrotranslocation: Lessons from Regulated ERAD- Department of Biological Chemistry Seminar (October 22, 2019 12:00pm) https://events.umich.edu/event/67922 67922-16966903@events.umich.edu Event Begins: Tuesday, October 22, 2019 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Randy Hampton, Professor of Biological Sciences at the University of California San Diego, will present the Department of Biological Chemistry Seminar

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Lecture / Discussion Wed, 02 Oct 2019 10:52:11 -0400 2019-10-22T12:00:00-04:00 2019-10-22T13:00:00-04:00 Medical Science Unit II Biological Chemistry Lecture / Discussion Hampton
Prediction Error & Model Evaluation for Space-Time Downscaling: case studies in air pollution during wildfires (October 22, 2019 1:00pm) https://events.umich.edu/event/68191 68191-17026797@events.umich.edu Event Begins: Tuesday, October 22, 2019 1:00pm
Location: Public Health I (Vaughan Building)
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

ABSTRACT:
Public Health Scientists use prediction models to downscale (i.e., interpolate) air pollution exposure where monitoring data is insufficient. This exercise aims to obtain estimates at fine resolutions, so that exposure data may reliably be related to health outcomes. In this setting, substantial research efforts have been dedicated to the development of statistical models capable of integrating heterogenous information to obtain accurate prediction: statistical downscaling models, land use regression, as well as machine learning strategies. However, when presented with the tasks of choosing between models, or averaging models, we find that our understanding of model performance in the absence of independent statistical replications remains insufficient. This lecture is motivated by several studies of air pollution (PM 2.5 and ground-level ozone) during wildfires. We review the basis for cross validation as a strategy for the estimation of the expected prediction error. As these performance measure play a crucial role in model selection and averaging we present a formal characterization of the estimands targeted by different data subsetting strategies, and explore their performance in engineered data settings. A final analysis and a warning about preference inversion is presented in relation to the a 2008 wildfire event in Northern California.

BIO:
Dr. Telesca is Associate Professor of Biostatistics at the University of California Los Angeles. He received a Ph.D. in Statistics from the University of Washington and spent two years at the University of Texas M.D. Anderson Cancer Center as a postdoctoral fellow. His research interests include Bayesian methods in multivariate statistics, functional data analysis, statistical methods in bio- and nano-informatics. Dr. Telesca is a member of the California NanoSystems Institute, the UCLA Jonsson Comprehensive Cancer Center and principal data scientist at Lucid Circuit Inc.

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Lecture / Discussion Wed, 09 Oct 2019 09:51:07 -0400 2019-10-22T13:00:00-04:00 2019-10-22T14:30:00-04:00 Public Health I (Vaughan Building) Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Donatello Telesca Environmental Statistics Day Lecture
Complex Systems & Soft Matter Group Seminar | The life and death of turbulence (October 22, 2019 3:00pm) https://events.umich.edu/event/68414 68414-17080052@events.umich.edu Event Begins: Tuesday, October 22, 2019 3:00pm
Location: North Campus Research Complex Building 10
Organized By: The Center for the Study of Complex Systems

A special seminar co-hosted by the Center for the Study of Complex Systems and the Soft Matter Group - Chemical Engineering to be held at the North Campus Research Center

ABSTRACT:
Turbulence is the last great unsolved problem of classical physics. But there is no consensus on what it would mean to actually solve this problem. In this colloquium, I propose that turbulence is most fruitfully regarded as a problem in non-equilibrium statistical mechanics, and will show that this perspective explains turbulent drag behavior measured over 80 years, and makes predictions that have been experimentally tested in 2D turbulent soap films. I will also explain how this perspective is useful in understanding the laminar-turbulence transition, establishing it as a non-equilibrium phase transition whose critical behavior has been predicted and tested experimentally. This work connects transitional turbulence with statistical mechanics and renormalization group theory, high energy hadron scattering, the statistics of extreme events, and even population biology.

___________
To get to the research auditorium, enter via Building 18 Visitors entrance, show ID, up stairs to the right (the big granite egg)

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Workshop / Seminar Tue, 15 Oct 2019 21:31:16 -0400 2019-10-22T15:00:00-04:00 2019-10-22T16:00:00-04:00 North Campus Research Complex Building 10 The Center for the Study of Complex Systems Workshop / Seminar Swanlund Professor of Physics Nigel Goldenfeld
Pizza with Professors (October 22, 2019 4:00pm) https://events.umich.edu/event/68576 68576-17103242@events.umich.edu Event Begins: Tuesday, October 22, 2019 4:00pm
Location: Undergraduate Science Building
Organized By: Program in Biology

The Departments of Molecular, Cellular, and Developmental Biology (MCDB) and Ecology and Evolutionary Biology (EEB) invite you to Pizza with Professors! This is an informal time to chat with MCDB and EEB professors about research, courses, and pre-professional studies over a slice of pizza!

Please RSVP here: https://forms.gle/hzpEbWV4SZfpfrkf6

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Careers / Jobs Fri, 18 Oct 2019 09:54:44 -0400 2019-10-22T16:00:00-04:00 2019-10-22T18:00:00-04:00 Undergraduate Science Building Program in Biology Careers / Jobs Join us for Pizza with Professors!
CDB Seminar: Torsin and other nuclear envelope proteins: Structural biology on a roller coaster (October 23, 2019 4:00pm) https://events.umich.edu/event/67428 67428-16849200@events.umich.edu Event Begins: Wednesday, October 23, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

2019 Cell & Developmental Biology Seminar Series

Hosted By: Kristen Verhey, PhD

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Lecture / Discussion Mon, 28 Oct 2019 15:52:52 -0400 2019-10-23T16:00:00-04:00 2019-10-23T17:00:00-04:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion CDB Seminar - Schwartz
Department of Computational Medicine & Bioinformatics Weekly Seminar Series (October 23, 2019 4:00pm) https://events.umich.edu/event/68168 68168-17020453@events.umich.edu Event Begins: Wednesday, October 23, 2019 4:00pm
Location:
Organized By: DCMB Seminar Series

Talk Title: "Chromatin accessibility signatures of immune system aging"

Abstract: Aging is linked to deficiencies in immune responses and increased systemic inflammation. To unravel regulatory programs behind these changes, we profiled peripheral blood mononuclear cells (PBMCs) from young and old individuals (n=77) using ATAC-seq and RNA-seq technologies and analyzed these data via systems immunology tools. First, we described an epigenomic signature of immune system aging, with simultaneous systematic chromatin closing at promoters and enhancers associated with T cell signaling. This signature was primarily borne by memory CD8+ T cells, which exhibited an aging-related loss in IL7R activity and IL7 responsiveness. More recently to uncover the impact of sex on immune system aging, we studied PBMCs from 194 healthy adults (100 women, 94 men) ranging from 22-93 years old using ATAC-seq, RNA-seq, and flow cytometry technologies. These data revealed a shared epigenomic signature of aging between sexes composed of declines in naïve T cell functions and increases in monocyte and cytotoxic cell functions. Despite similarities, these changes were greater in magnitude in men. Additionally, we uncovered male-specific decreases in expression/accessibility of B-cell associated loci. Trajectory analyses revealed that age-related epigenomic changes were more abrupt at two timepoints in the human lifespan. The first timepoint was similar between sexes in terms of timing (early forties) and magnitude. In contrast, the latter timepoint was earlier (~5 years) and more pronounced in men (mid-sixties versus late-sixties). Unexpectedly, differences between men and women PBMCs increased with aging, with men having higher monocyte and pro-inflammatory activity and lower B/T cell activity compared to women after 65 years of age. Our study uncovered which immune cell functions and molecules are differentially affected with age between sexes, including the differences in timing and magnitude of changes, which is an important step towards precision medicine in older adults.

3:45 pm - Light refreshments served
4:00 pm - Lecture

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Lecture / Discussion Tue, 08 Oct 2019 15:12:18 -0400 2019-10-23T16:00:00-04:00 2019-10-23T17:00:00-04:00 DCMB Seminar Series Lecture / Discussion
Development of metal-oxide clusters as charge-carriers for nonaqueous redox-flow batteries (October 23, 2019 4:00pm) https://events.umich.edu/event/64523 64523-16382900@events.umich.edu Event Begins: Wednesday, October 23, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Effective integration of renewable energy from intermittent sources (i.e. solar and wind) requires the development of efficient energy storage systems which can function in tandem with the electrical grid. Non-aqueous redox-flow batteries have emerged as promising systems for large-capacity, reversible energy storage capable of meeting the variable demands of the electrical grid. The use of non-aqueous solvents increases the energy density of these systems, however there are few electrolytes with sufficient solubility and electrochemical stability to function in organic media. In this work, we investigate the potential for Lindqvist polyoxovanadate-alkoxide (POV-alkoxide) clusters to serve as both the anolyte and catholyte for symmetric, non-aqueous redox-flow batteries. POV-alkoxide clusters display numerous, highly reversible redox events, and demonstrate significant solubility and electrochemical stability in organic solvents. These bulky compounds also demonstrate the ability to mitigate species crossover and membrane fouling, thereby improving the energy efficiency and lifetime of flow battery cells. The application of POV-alkoxides as electrolytes in organic media demonstrates that the remarkable redox properties of multimetallic clusters can be harnessed for non-aqueous energy storage applications, and represents an important new direction for the generation of high performance redox-flow batteries.








Ellen Matson (University of Rochester)

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Other Wed, 23 Oct 2019 18:15:49 -0400 2019-10-23T16:00:00-04:00 2019-10-23T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Science, Technology, and Public Policy Graduate Certificate Info Session (October 23, 2019 4:00pm) https://events.umich.edu/event/67933 67933-16969022@events.umich.edu Event Begins: Wednesday, October 23, 2019 4:00pm
Location: Weill Hall (Ford School)
Organized By: Science, Technology, and Public Policy (STPP) Program

Join us for an information session about the Science, Technology, and Public Policy (STPP) Graduate Certificate!

Wednesday, October 23rd, 4:00pm-5:00pm
5240 Weill Hall
There will be SNACKS!

Do you want to learn how science and technology policy is made? Are you interested in the social and ethical implications of developments like gene editing and autonomous vehicles? Are you concerned about the increased politicization of science and research funding?

In the STPP graduate certificate program, graduate students from across the University analyze the role of science and technology in the policymaking process, gain experience writing for policymakers, and explore the political and policy landscape of areas such as biotechnology, information technology, energy, and others. Graduates of the STPP certificate have gone on to a range of policy-engaged scientific roles in government, NGOs, and academia.

More information about the program is available at: http://stpp.fordschool.umich.edu/graduate-certificate/

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Presentation Wed, 02 Oct 2019 13:21:49 -0400 2019-10-23T16:00:00-04:00 2019-10-23T17:00:00-04:00 Weill Hall (Ford School) Science, Technology, and Public Policy (STPP) Program Presentation Information Session promotional slide
BME Seminar: Jason Papin, Ph.D. (October 24, 2019 9:00am) https://events.umich.edu/event/68620 68620-17105386@events.umich.edu Event Begins: Thursday, October 24, 2019 9:00am
Location: Chrysler Center
Organized By: Biomedical Engineering

New experimental technologies to characterize microbes result in voluminous data on the genotype-phenotype relationship under diverse conditions. Computer models have become indispensable tools to integrate such data and facilitate the generation and testing of hypotheses. We will discuss recent methods to construct and test computer models of microbial metabolism that are being used to identify novel drug targets and characterize the evolution of antibiotic resistance.

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Lecture / Discussion Fri, 18 Oct 2019 15:23:24 -0400 2019-10-24T09:00:00-04:00 2019-10-24T10:00:00-04:00 Chrysler Center Biomedical Engineering Lecture / Discussion BME Logo
Donuts and Design Science (October 24, 2019 11:00am) https://events.umich.edu/event/66691 66691-16770220@events.umich.edu Event Begins: Thursday, October 24, 2019 11:00am
Location: Duderstadt Center
Organized By: Integrative Systems + Design

Drop in grab a free donut and learn more about the Design Science graduate program.

Design Science allows you to study the world as we make it. Design Science demands an innovative paradigm for research, education, and practice, and offers a unique interdisciplinary approach requiring you to integrate two or more traditional disciplines to tackle modern, complex design problems.

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Other Mon, 09 Sep 2019 14:37:20 -0400 2019-10-24T11:00:00-04:00 2019-10-24T12:30:00-04:00 Duderstadt Center Integrative Systems + Design Other Duderstadt Center
MedChem Seminar (October 24, 2019 1:00pm) https://events.umich.edu/event/68815 68815-17155485@events.umich.edu Event Begins: Thursday, October 24, 2019 1:00pm
Location:
Organized By: Department of Medicinal Chemistry

Trimming the C-terminal tail of alpha-tubulin: What is it good for?

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Lecture / Discussion Thu, 24 Oct 2019 13:36:22 -0400 2019-10-24T13:00:00-04:00 2019-10-24T14:00:00-04:00 Department of Medicinal Chemistry Lecture / Discussion
MedChem Seminar (October 24, 2019 1:00pm) https://events.umich.edu/event/68815 68815-17155486@events.umich.edu Event Begins: Thursday, October 24, 2019 1:00pm
Location:
Organized By: Department of Medicinal Chemistry

Trimming the C-terminal tail of alpha-tubulin: What is it good for?

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Lecture / Discussion Thu, 24 Oct 2019 13:36:22 -0400 2019-10-24T13:00:00-04:00 2019-10-24T14:00:00-04:00 Department of Medicinal Chemistry Lecture / Discussion
MedChem Seminar (October 24, 2019 1:00pm) https://events.umich.edu/event/68815 68815-17155487@events.umich.edu Event Begins: Thursday, October 24, 2019 1:00pm
Location:
Organized By: Department of Medicinal Chemistry

Trimming the C-terminal tail of alpha-tubulin: What is it good for?

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Lecture / Discussion Thu, 24 Oct 2019 13:36:22 -0400 2019-10-24T13:00:00-04:00 2019-10-24T14:00:00-04:00 Department of Medicinal Chemistry Lecture / Discussion
EEB and the Institute for Global Change Biology Thursday Seminar: The long-term climate change mitigation potential of working lands (October 24, 2019 4:00pm) https://events.umich.edu/event/65474 65474-16605608@events.umich.edu Event Begins: Thursday, October 24, 2019 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Land management has been proposed as a means to help lower greenhouse gas emissions and reduce atmospheric carbon dioxide (CO2) concentrations. Research in California has shown significant potential to lower methane emissions from waste management and subsequently increase short-term soil carbon (C) storage via amendments of composted organic material. However, effective climate change mitigation will require long-term or sustained emissions reduction and C sequestration. We used field experiments and modeling to explore the long-term potential of improved agricultural practices on greenhouse gas emissions and ecosystem C cycling. A decade following a one-time application of composted organic matter to grassland soils, amended plots accumulated approximately 9 Mg C ha-1 more soil C in the top 30 cm than paired controls. Aboveground plant growth was also higher in the amended plots after 10 years. Soil C stocks and C sequestration rates in compost-amended plots were resistant to rainfall and temperature changes predicted by Earth Systems Models (ESMs). We used two climate models (HadGEM and CanESM) and two climate change scenarios (RCP 4.5 and RCP 8.5) to determine the sensitivity of rangeland C dynamics to climate change with and without composted amendments to the year 2100. Drier sites yielded surprisingly high rates of C storage and were less sensitive to climate change than wetter sites. We also used a new micrometeorological approach to estimate greenhouse gas fluxes from composted manure, green waste, and food waste, the highest emitting organic waste streams. We found that manure and green waste had considerably lower methane emission factors than food waste, and that all composted wastes had lower emission factors with composting than with landfilling or slurrying. Our results show that there are alternative management approaches can both lower greenhouse gas emissions and sequester atmospheric CO2 over short and long time periods, and thus provide viable climate change mitigation approaches.

View YouTube video of seminar: https://youtu.be/0JjEXOx9mQ8

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Workshop / Seminar Thu, 02 Apr 2020 12:54:38 -0400 2019-10-24T16:00:00-04:00 2019-10-24T17:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar EEB Seminar Silver
Measuring Students' Understandings of Multiple Representations in Chemistry (October 24, 2019 4:00pm) https://events.umich.edu/event/65050 65050-16509310@events.umich.edu Event Begins: Thursday, October 24, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Learning chemistry requires students to become fluent in the symbolic language of chemistry. Developing expertise, however, requires that students move beyond manipulating symbols to create explanations using particulate models of matter for observations in the laboratory. Failure to accurately interpret and connect these multiple representations of matter is one source of students’ misconceptions. Our research group designs measurement tools to advance our understanding of how students understand and interpret representations for a variety of core concepts. Creating such measures presents multiple challenges with regard to establishing the precision and accuracy of the data. Insights regarding the underlying assumptions and appropriateness of commonly used psychometrics will be examined. Findings regarding students’ reasoning and misconceptions will be presented with examples drawn from general chemistry, organic chemistry, physical chemistry, and biochemistry courses.













Stacey Lowery Bretz (Miami University)

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Other Thu, 24 Oct 2019 18:15:47 -0400 2019-10-24T16:00:00-04:00 2019-10-24T17:15:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Manufacturing Seminar Series (October 25, 2019 11:00am) https://events.umich.edu/event/68554 68554-17096951@events.umich.edu Event Begins: Friday, October 25, 2019 11:00am
Location: Chrysler Center
Organized By: Integrative Systems + Design

Join us Friday, October 25, 2019 from 11:00 am-12:00 pm in Chrysler Center, Room 151 (2121 Bonisteel Blvd, Ann Arbor) for our Manufacturing Seminar Series Speaker, with Alan Taub. Taub is a Professor of Materials Science & Engineering and Mechanical Engineering.

In this presentation, Taub will expalin the role of Lightweight Innovations for Tomorrow (LIFT) and its connection with the University of Michigan in developing these new lightweighting technologies will be highlighted.

RSVP here: https://docs.google.com/forms/d/1KEE1YVxoQ9tvu25fOoVTpi-V8DM05_LcQlB8hXPfE48/edit

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Workshop / Seminar Thu, 17 Oct 2019 13:59:24 -0400 2019-10-25T11:00:00-04:00 2019-10-25T12:00:00-04:00 Chrysler Center Integrative Systems + Design Workshop / Seminar MFG Seminar
Biophysics Student Seminar (October 25, 2019 12:00pm) https://events.umich.edu/event/68668 68668-17130536@events.umich.edu Event Begins: Friday, October 25, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Shiyuan Wang - Yang Lab
Talk title: Understanding the Mitotic Oscillations with a Droplet-based System: How Does ATP Level Affect Oscillation Characteristics?

Ryan Hayes - Brooks Lab
Talk Title: Towards Protein Design with Rigorous Alchemical Calculation of
Folding Free Energies

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Workshop / Seminar Mon, 21 Oct 2019 15:42:14 -0400 2019-10-25T12:00:00-04:00 2019-10-25T13:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
MCDB Seminar: Telomerase RNA Biogenesis: Human Genetics to Therapeutic Prospects (October 25, 2019 12:00pm) https://events.umich.edu/event/67357 67357-16839925@events.umich.edu Event Begins: Friday, October 25, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: JK Nandakumar

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Workshop / Seminar Tue, 17 Sep 2019 16:28:46 -0400 2019-10-25T12:00:00-04:00 2019-10-25T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar micrograph of teleomeres
ACS Lecture -Undergraduate (October 28, 2019 4:00pm) https://events.umich.edu/event/65967 65967-16678370@events.umich.edu Event Begins: Monday, October 28, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry
















Aurora Pribram-Jones (UC Merced)

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Other Mon, 28 Oct 2019 18:15:40 -0400 2019-10-28T16:00:00-04:00 2019-10-28T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
RNA Innovation Seminar, Luis Batista, Washington University in St. Louis (October 28, 2019 4:00pm) https://events.umich.edu/event/65140 65140-16539450@events.umich.edu Event Begins: Monday, October 28, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Luis Batista, PhD, Assistant Professor of Medicine and Developmental Biology, Washington University in St. Louis

Abstract: The overarching goal of the Batista lab is to understand the regulation and function of telomerase in tissue fitness, disease, and cancer. The Batista laboratory uses genome-wide methods to uncover alterations that drive cellular failure upon critical telomerase dysfunction, using the targeted differentiation of human pluripotent stem cells to tissues of clinical relevance as a primary model. We combine in vitro biochemical and mechanistic studies with our ability to generate and differentiate pluripotent cells towards different fates to better understand the importance of correct ribonucleoprotein assembly and function in tissue fitness and to determine the events that lead from impaired RNA-protein assembly to disease in humans.

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Lecture / Discussion Wed, 25 Sep 2019 11:00:45 -0400 2019-10-28T16:00:00-04:00 2019-10-28T17:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion flyer
CDB Dissertation Defense: Ye Li (October 29, 2019 10:00am) https://events.umich.edu/event/68769 68769-17147156@events.umich.edu Event Begins: Tuesday, October 29, 2019 10:00am
Location: Medical Science Research Building 2
Organized By: Cell & Developmental Biology

“Exploring neuronal heterogeneity in the Drosophila nervous system with novel neurotechnologies.”

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Lecture / Discussion Wed, 23 Oct 2019 13:20:35 -0400 2019-10-29T10:00:00-04:00 2019-10-29T11:00:00-04:00 Medical Science Research Building 2 Cell & Developmental Biology Lecture / Discussion Ye Li Dissertation Seminar
Complex Systems Seminar | Stephanie Forrest 'The Biology of Software: Evolution, Robustness, Diversity' (October 29, 2019 11:30am) https://events.umich.edu/event/68316 68316-17045998@events.umich.edu Event Begins: Tuesday, October 29, 2019 11:30am
Location: Weiser Hall
Organized By: The Center for the Study of Complex Systems

**Please note, if this room's capacity is exceeded, there will be a simulcast into the next room of talk slides and audio**

Stephanie Forrest is Professor of Computer Science at Arizona State University, where she directs the Biodesign Center for Biocomputation, Security and Society. Her research focuses on the intersection of biology and computation, including cybersecurity, software engineering, and biological modeling.

Abstract:
Software today is a complex adaptive system. Although we think of computer programs as the products of intelligent design, they also evolve inadvertently through the actions of many individual programmers, often leading to unanticipated consequences. Similarly, economic and political incentives produce arms races between competitors and adversaries, which in turn have shaped the cyber landscape.

The talk will give examples of evolution, robustness and diversity in the context of software, describing how these concepts provide new insights and suggest new approaches to problems such as repairing software bugs and cybersecurity. It will present recent results on the mutational robustness of software and describe a new algorithm for bug repair that leverages neutral mutations.


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Prior to joining ASU in 2017, Professor Forrest was at the University of New Mexico and served as Dept. Chair 2006-2011. She is a member of the Santa Fe Institute External Faculty and 2013-2014 served at the U.S. Dept. of State as a Senior Science Advisor for cyberpolicy. She was educated at St. John's College (B.A.) and the University of Michigan (M.S. and Ph.D. in Computer Science).

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Workshop / Seminar Mon, 28 Oct 2019 13:11:45 -0400 2019-10-29T11:30:00-04:00 2019-10-29T13:00:00-04:00 Weiser Hall The Center for the Study of Complex Systems Workshop / Seminar Stephanie Forrest
EEB Tuesday Lunch Seminar: The ecosystem consequences of wildfire activity over space and time: a field station perspective (October 29, 2019 12:00pm) https://events.umich.edu/event/65002 65002-16501301@events.umich.edu Event Begins: Tuesday, October 29, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Recent changes in ecosystem properties highlight major uncertainties about how disturbances will interact with ongoing climate change. Shifting fire regimes may lead to long-lasting directional changes or shifts in biogeochemical states, potentially impacting carbon and nitrogen balance over large spatial and temporal scales. However, data have been lacking to test these ideas over longer timescales – and to consider their implications for future projections – until only recently. A network of paleoecological records will document the role of climate in past fire-regime variability, and the potential for changing biogeochemical impacts will be evaluated. Combined with inferences from ecosystem and Earth system models, these results characterize how disturbances shape biogeochemical dynamics across a range of spatial and temporal scales. The important role of biological stations in catalyzing cutting-edge research, education, and outreach will also be explored.

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Workshop / Seminar Mon, 28 Oct 2019 11:24:40 -0400 2019-10-29T12:00:00-04:00 2019-10-29T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Ecosystem Wildfire - McLauchlan
Organelle Relationships in Aging and Disease- Department of Biological Chemistry Seminar (October 29, 2019 12:00pm) https://events.umich.edu/event/67925 67925-16966906@events.umich.edu Event Begins: Tuesday, October 29, 2019 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Adam Hughes, Assistant Professor of Biochemistry at the University of Utah, will be delivering the Department of Biological Chemistry Seminar.

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Film Screening Wed, 02 Oct 2019 11:03:08 -0400 2019-10-29T12:00:00-04:00 2019-10-29T13:00:00-04:00 Medical Science Unit II Biological Chemistry Film Screening Hughes
9th Annual Thomas D. Gelehrter M.D. Lecture in Medical Genetics (October 29, 2019 2:00pm) https://events.umich.edu/event/65874 65874-16662158@events.umich.edu Event Begins: Tuesday, October 29, 2019 2:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Department of Human Genetics

Helen H. Hobbs, M.D., is an Investigator of the Howard Hughes Medical Institute and a Professor of Internal Medicine and Molecular Genetics at the University of Texas Southwestern Medical Center. Among Dr. Hobbs’ honors was her election to the National Academy of Medicine in 2004 and National Academy of Sciences in 2007. She received the Breakthrough Prize in Life Sciences and Passano Award (with Jonathan Cohen) in 2016 and the Harrington Prize for Innovation in Medicine in 2018. Dr. Hobbs is recognized for her contributions to the development of new lipid-lowering strategies by identifying genetic variants of large effect in humans. Importantly, her work created a new strategy using human genetics to identify new therapeutic targets for the treatment of complex cardiovascular and metabolic disorders.

This lecture honors Thomas D. Gelehrter, M.D., active emeritus professor and former Chair of the Department of Human Genetics at the University of Michigan.

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Lecture / Discussion Tue, 27 Aug 2019 16:59:30 -0400 2019-10-29T14:00:00-04:00 2019-10-29T17:00:00-04:00 Taubman Biomedical Science Research Building Department of Human Genetics Lecture / Discussion Dr. Helen H. Hobbs
MedChem Seminar (October 29, 2019 2:30pm) https://events.umich.edu/event/68813 68813-17155482@events.umich.edu Event Begins: Tuesday, October 29, 2019 2:30pm
Location: Pharmacy College
Organized By: Department of Medicinal Chemistry

Understanding—and Overcoming—Therapy Resistance in Breast and Prostate Cancers

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Lecture / Discussion Thu, 24 Oct 2019 12:58:51 -0400 2019-10-29T14:30:00-04:00 2019-10-29T15:30:00-04:00 Pharmacy College Department of Medicinal Chemistry Lecture / Discussion Pharmacy College
Functional MRI Speaker Series (October 29, 2019 4:00pm) https://events.umich.edu/event/67389 67389-16846424@events.umich.edu Event Begins: Tuesday, October 29, 2019 4:00pm
Location: East Hall
Organized By: Functional MRI Lab

Title: Clinical Neuropsychologist and Professor of Psychiatry
Department of Psychiatry University of Utah

Abstract: Rumination is a feature of major depressive disorder, that is considered a passive, negative, and recurrent thought patterns and habits. Like negative cognitive biases, rumination reflects the thought content (negative, potentially distorted) typical of depression. Unlike negative cognitive biases, rumination also includes habitual tendencies in responding to stressors (avoidance, passivity) which are not clearly or necessarily ascribed to negative thought patterns. As depressive rumination includes both content and habit it has been difficult to measure well. The fact that it may reflect a disengaged state from active cognitive processing means that it is often ascertained through the absence of certain mental states and behaviors, which also makes measurement challenging. The talk will focus on fMRI paradigms that are thought to capture the ruminative state and habit, behavioral correlates of increased rumination, and the relations of rumination to depression risk, poor treatment response, and frequent recurrence of depression. Moreover, it will cover strategies to intervene to change rumination, and resulting changes in resting state connectivity and task-based brain activation.

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Lecture / Discussion Wed, 18 Sep 2019 11:24:00 -0400 2019-10-29T16:00:00-04:00 2019-10-29T17:30:00-04:00 East Hall Functional MRI Lab Lecture / Discussion Langenecker Photo
CDB Seminar - Cargo Receptors in the ER: From Clotting Factors to Cholesterol Regulation (October 30, 2019 9:30am) https://events.umich.edu/event/67430 67430-16849214@events.umich.edu Event Begins: Wednesday, October 30, 2019 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

2019 Cell & Developmental Biology Seminar Series

Hosted By: Doug Engel, PhD

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Lecture / Discussion Mon, 28 Oct 2019 15:55:29 -0400 2019-10-30T09:30:00-04:00 2019-10-30T10:30:00-04:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion CDB Seminar - Ginsburg
Leveraging Electrophilicity and Polarizability in Catalysts for Challenging Coupling Reactions (October 30, 2019 4:00pm) https://events.umich.edu/event/67457 67457-16857831@events.umich.edu Event Begins: Wednesday, October 30, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

A general approach by our group for the development of new catalytic synthetic methods that occur with higher efficiency and selectivity, use simpler reagents, and proceed with lower energy demand involves new ancillary ligand design coupled with fundamental studies of how metal-ligand bonding dictates catalytic reactivity. In this context, the presentation will focus on our recent efforts to discover new phosphorus- and sulfur-based ligands and associated metal catalysts that manifest special properties from seemingly "weak" interactions, for instance dispersion. In one case, low-coordinate Pd complexes possessing polarizable diamondoid substituents are shown to enable a new transmetalation mechanism under exceptionally mild conditions, facilitate the first ever characterization and reactivity studies of monoligated Pd(0) – the true active catalyst in modern cross-coupling reactions, and enable direct visible light-induced bond weakening. Studies of oxidative dehydrogenative coupling reactions will also showcase evidence for a distinct C−H bond activation mechanism that we describe as electrophilic CMD or "eCMD", which has characteristics distinct from established pathways for C−H functionalization. Transition state analyses suggest this reaction pathway could be a general class of C−H activation that to date has been convoluted with the classic concerted metalation-deprotonation (CMD) model, and selection rules have been identified for predicting what catalyst structures manifest either CMD or eCMD, each of which occurs with characteristic substrate preferences and selectivity.








Bradley Carrow (Princeton University)

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Other Wed, 30 Oct 2019 18:15:13 -0400 2019-10-30T16:00:00-04:00 2019-10-30T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
EEB Thursday Seminar: Unraveling the tangled web: the evolutionary impact of hybridization (October 31, 2019 4:00pm) https://events.umich.edu/event/65475 65475-16605609@events.umich.edu Event Begins: Thursday, October 31, 2019 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

How distinct species persist in the face of gene flow is a long-standing and central question in evolutionary biology, reinvigorated by the recent realization that hybridization is surprisingly common. Though it is now appreciated that gene flow often occurs before, during, and after speciation, little about the evolutionary impact of hybridization is understood, from the ecological and behavioral forces driving hybridization to the ways in which selection acts on hybrid genomes. Our research addresses these questions using replicate, recently formed hybrid populations of swordtail fish. I will discuss work mapping the locations of hybrid incompatibilities and investigating the role of selection on these regions in hybrid genome evolution. I will also discuss our work investigating how selection on incompatibilities interacts with other genetic processes such as recombination. Together, this work highlights a set of mechanisms that shape hybridization on a population and genetic level.

View YouTube video of seminar: https://youtu.be/NX1wEe5CCzk

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Workshop / Seminar Fri, 10 Apr 2020 14:16:23 -0400 2019-10-31T16:00:00-04:00 2019-10-31T17:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Image of Hybrid Fish
MedChem Seminar (October 31, 2019 4:00pm) https://events.umich.edu/event/68814 68814-17155483@events.umich.edu Event Begins: Thursday, October 31, 2019 4:00pm
Location: Pharmacy College
Organized By: Department of Medicinal Chemistry

Visualizing Microbial and Cellular Chemistry in Situ

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Lecture / Discussion Thu, 24 Oct 2019 13:01:37 -0400 2019-10-31T16:00:00-04:00 2019-10-31T17:00:00-04:00 Pharmacy College Department of Medicinal Chemistry Lecture / Discussion Pharmacy College
ISD Manufacturing Seminar Series (November 1, 2019 10:30am) https://events.umich.edu/event/68798 68798-17153401@events.umich.edu Event Begins: Friday, November 1, 2019 10:30am
Location: Chrysler Center
Organized By: Integrative Systems + Design

Join us Friday, November 8, 2019 from 11:00am-12:00pm in Chrysler Center, Room 151 (2121 Bonisteel Blvd, Ann Arbor) for our Manufacturing Seminar Series Speaker, with Xun Huan, Ph.D. Professor Huan is an Assistant Professor of Mechanical Engineering at the University of Michigan.

In this presentation, Dr. Huan will talk about finding the most useful data and how using a careful design of limited data acquisition opportunities can lead to substantial resource savings.
RSVP here: https://forms.gle/b94JCeg23jJwu3Li9

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Workshop / Seminar Tue, 05 Nov 2019 12:25:41 -0500 2019-11-01T10:30:00-04:00 2019-11-01T11:30:00-04:00 Chrysler Center Integrative Systems + Design Workshop / Seminar MFG Seminar
U-M Structure Seminar: LRRK2, Rab GTPases, and Parkinson’s disease (November 1, 2019 10:30am) https://events.umich.edu/event/65766 65766-16654001@events.umich.edu Event Begins: Friday, November 1, 2019 10:30am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

Associate Professor, Biochemistry
Trinity College, The University of Dublin

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Lecture / Discussion Mon, 26 Aug 2019 13:46:03 -0400 2019-11-01T10:30:00-04:00 2019-11-01T11:30:00-04:00 Life Sciences Institute U-M Structural Biology Lecture / Discussion Life Sciences Institute
Biophysics Talk Title: TBD (November 1, 2019 12:00pm) https://events.umich.edu/event/64274 64274-16274484@events.umich.edu Event Begins: Friday, November 1, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: TBD

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Workshop / Seminar Wed, 10 Jul 2019 09:39:20 -0400 2019-11-01T12:00:00-04:00 2019-11-01T13:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
CALCIUM - Panel: Industry to Academia (November 1, 2019 12:00pm) https://events.umich.edu/event/67850 67850-16960491@events.umich.edu Event Begins: Friday, November 1, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

ChemEd

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Other Fri, 01 Nov 2019 18:15:21 -0400 2019-11-01T12:00:00-04:00 2019-11-01T13:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
EEB Seminar Series: Leveraging the power of place to explore, educate and predict how the natural world works now and in the future (November 1, 2019 12:00pm) https://events.umich.edu/event/68571 68571-17103237@events.umich.edu Event Begins: Friday, November 1, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Field stations provide platforms for transformative long-term and placed-based research as well as extraordinary opportunities for education and outreach. Dr. Classen will discuss her field station vision using some examples from her own work exploring ecosystem and global change ecology. Broadly, the Classen group explores how ecosystems function and how biotic and abiotic interactions influence patterns and processes within and among communities and ecosystems. Working across scales from the micro (soil food webs) to the macro (regional carbon fluxes) as well as across diverse terrestrial ecosystems (forests, meadows, bogs; tropics, arctic, temperate) the Classen lab uses a combination of observations, experiments, and models to answer ecological and global change questions

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Workshop / Seminar Tue, 29 Oct 2019 13:08:07 -0400 2019-11-01T12:00:00-04:00 2019-11-01T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Dr. Classen in the field
MCDB Seminar: UTI Pathogenesis, Host-Pathogen Interface, Antibiotic-sparing therapeutics (November 1, 2019 12:00pm) https://events.umich.edu/event/67348 67348-16839904@events.umich.edu Event Begins: Friday, November 1, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Matt Chapman

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Workshop / Seminar Tue, 17 Sep 2019 15:23:11 -0400 2019-11-01T12:00:00-04:00 2019-11-01T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar high resolution micrograph of pathogenic bacteria binding to tissue
The Annual Bernard W. Agranoff Lectureship in Neuroscience (November 4, 2019 3:15pm) https://events.umich.edu/event/68666 68666-17136728@events.umich.edu Event Begins: Monday, November 4, 2019 3:15pm
Location: University Hospitals
Organized By: Michigan Neuroscience Institute

This annual lectureship features a pre-eminent neuroscientist and honors Bernard W. Agranoff, a leader in biochemistry and an internationally recognized expert in the neurosciences. Dr. Agranoff is a graduate of the University of Michigan who returned as a faculty member in 1960. He served as the Director of Mental Health Research Institute (now known as the Molecular and Behavioral Neuroscience Institute) from 1985 to 1995 and was the Neuroscience Laboratory Building Director from 1983-2002. His scientific career helped establish that long-term memory formation requires de novo protein synthesis and also enhanced our understanding of the processes involved in nerve regeneration. The Lectureship builds upon a career dedicated to promoting excellence in research, education, and mental health care and is an enduring legacy to those seeking to improve our understanding of the brain and apply that knowledge to help those with brain disorders.

Dr. Richard Huganir is the 2019 Agranoff Lecturer. Dr. Huganir is a Bloomberg Distinguished Professor of Neuroscience and Psychological and Brain Sciences and Director of the Solomon H. Snyder Department of Neuroscience at the Johns Hopkins School of Medicine. His career has focused on synapses in the brain. His research has shown that the regulation of receptor function is a major mechanism for the regulation of neuronal excitability and connectivity in the brain and is critical for many higher brain processes, including learning and memory, and is a major determinant of behavior. Moreover, dysregulation of these mechanisms underlies many neurological and psychiatric diseases including Alzheimer’s, ALS, schizophrenia, autism, intellectual disability, PTSD as well as in chronic pain and drug addiction. Dr. Huganir is a member of the American Academy of Arts and Sciences, the National Institute of Medicine and the National Academy of Sciences.

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Lecture / Discussion Tue, 22 Oct 2019 10:00:19 -0400 2019-11-04T15:15:00-05:00 2019-11-04T16:30:00-05:00 University Hospitals Michigan Neuroscience Institute Lecture / Discussion Dr. Richard Huganir
The Molecular and Integrative Physiology Seminar Series is proud to present and welcome all to attend: (November 4, 2019 4:00pm) https://events.umich.edu/event/69102 69102-17244692@events.umich.edu Event Begins: Monday, November 4, 2019 4:00pm
Location: Medical Science Unit II
Organized By: Biosciences Initiative

"Designing chemogenetic and optogenetic tools for mapping and modulating GPCR signaling."

Light refreshments will be served at 3:45pm

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Workshop / Seminar Mon, 04 Nov 2019 14:41:57 -0500 2019-11-04T16:00:00-05:00 2019-11-04T17:00:00-05:00 Medical Science Unit II Biosciences Initiative Workshop / Seminar
Complex Systems Seminar | Network reconstruction and community detection from dynamics (November 5, 2019 11:30am) https://events.umich.edu/event/68329 68329-17046008@events.umich.edu Event Begins: Tuesday, November 5, 2019 11:30am
Location: Weiser Hall
Organized By: The Center for the Study of Complex Systems

The observed functional behavior of a wide variety large-scale systems is often the result of a network of pairwise interactions between individual elements. However, in many cases these interactions are hidden from us, either because they are impossible to be measured directly, or because their measurement can be done only at significant experimental cost. In such situations, we are required to infer the network of interactions from the observed functional behavior.

In this talk, I will present a scalable nonparametric Bayesian method to perform network reconstruction from observed functional behavior, that at the same time infers the modular structure (or "communities") present in the network. I will show how the joint reconstruction with community detection has a synergistic effect, where the edge correlations used to inform the existence of communities are also inherently used to improve the accuracy of the reconstruction which, in turn, can better inform the uncovering of communities. I will illustrate the use of the method with observations arising from epidemic models and the Ising model, both on synthetic and empirical networks, as well as on data containing only functional information.

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Workshop / Seminar Wed, 30 Oct 2019 09:25:09 -0400 2019-11-05T11:30:00-05:00 2019-11-05T13:00:00-05:00 Weiser Hall The Center for the Study of Complex Systems Workshop / Seminar Tiago Peixoto
EEB Tuesday Lunch Seminar: Using mechanistic experiments, macroecology, and the Michigan Biological Station to understand biodiversity in a changing world (November 5, 2019 12:00pm) https://events.umich.edu/event/65003 65003-16501302@events.umich.edu Event Begins: Tuesday, November 5, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Please join us for our weekly brown bag lunch seminar.

In this talk, I'll summarize our work aimed at understanding the factors that shape biodiversity, from m2 quadrats to the globe. In particular, I will highlight how our work blends macroecological approaches, physiological experiments in the lab, and experimental manipulations in the field, mostly on ants. My view is that this synthetic approach, across scales, is the best way to understand and predict how biodiversity responds to global change drivers. Field stations are perfect launching pads for this kind of research and for introducing students, across disparate disciplines, to biodiversity and the services and functions it provides. Field stations can also be hubs for interdisciplinary collaborations and provide opportunities to ask, and address, pressing and fundamental questions across fields. The UMBS has been both a launching pad and hub for decades and is poised for continued growth and success.

View YouTube video of seminar: https://youtu.be/ND2ttvGjZ7U

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Workshop / Seminar Thu, 02 Apr 2020 13:06:58 -0400 2019-11-05T12:00:00-05:00 2019-11-05T13:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Experimental manipulations in the field, mostly on ants.
Mechanisms of Ribosome-Associated Quality Control- Biological Chemistry Seminar (November 5, 2019 12:00pm) https://events.umich.edu/event/68247 68247-17035290@events.umich.edu Event Begins: Tuesday, November 5, 2019 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Sichen Shao, Assistant Professor of Cell Biology at Harvard Medical School, will deliver the weekly Department of Biological Chemistry Seminar on Tuesday November 5th, 2019. Please join us in North Lecture Hall, MS II for this seminar.

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Lecture / Discussion Thu, 10 Oct 2019 07:46:26 -0400 2019-11-05T12:00:00-05:00 2019-11-05T13:00:00-05:00 Medical Science Unit II Biological Chemistry Lecture / Discussion Sichen Shao
Genetics of Invasive Glioblastoma Cells (November 5, 2019 4:00pm) https://events.umich.edu/event/67119 67119-16803020@events.umich.edu Event Begins: Tuesday, November 5, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for Cell Plasticity and Organ Design

2019 – 2020 Center for Organogenesis Seminar Series
Faculty Host: Xing Fan, Ph.D.
For additional information contact: organogenesis@umich.edu

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Lecture / Discussion Fri, 13 Sep 2019 10:08:43 -0400 2019-11-05T16:00:00-05:00 2019-11-05T17:00:00-05:00 Taubman Biomedical Science Research Building Center for Cell Plasticity and Organ Design Lecture / Discussion Genetics of Invasive Glioblastoma Cells
Neuroscience/Pre-Health Walk-In Co-Advising Session (November 6, 2019 11:00am) https://events.umich.edu/event/69093 69093-17244686@events.umich.edu Event Begins: Wednesday, November 6, 2019 11:00am
Location: Undergraduate Science Building
Organized By: Program in Biology

Come have your questions about neuroscience or pre-health studies answered during our Walk-In Co-Advising Session! Advisors will be ready to answer your questions!

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Careers / Jobs Mon, 04 Nov 2019 12:32:28 -0500 2019-11-06T11:00:00-05:00 2019-11-06T13:00:00-05:00 Undergraduate Science Building Program in Biology Careers / Jobs
Department of Computational Medicine & Bioinformatics Weekly Seminar (November 6, 2019 4:00pm) https://events.umich.edu/event/68926 68926-17197024@events.umich.edu Event Begins: Wednesday, November 6, 2019 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract: Although central architectures drive robust oscillations, biological clock networks containing the same core vary drastically in their potential to oscillate. What peripheral structures contribute to the variation of oscillation behaviors remains elusive. We computationally generated an atlas of oscillators and found that, while certain core topologies are essential for robust oscillations, local structures substantially modulate the degree of robustness. Strikingly, two key local structures, incoherent inputs and coherent inputs, can modify a core topology to promote and attenuate its robustness, additively. These findings underscore the importance of local modifications besides robust cores, which explain why auxiliary structures not required for oscillation are evolutionarily conserved. We further apply this computational framework to search for structures underlying tunability, another crucial property shared by many biological timing systems to adapt their frequencies to environmental changes.

Experimentally, we developed an artificial cell system to reconstitute mitotic oscillatory processes in water-in-oil microemulsions. With a multi-inlet pressure-driven microfluidic setup, these artificial cells are flexibly adjustable in sizes, periods, various molecular and drug concentrations, energy, and subcellular compartments. Using long-term time-lapse fluorescence microscopy, this system enables high-throughput, single-cell analysis of clock dynamics, functions, and stochasticity, key to elucidating the topology-function relation of biological clocks.

We also investigate how multiple clocks coordinate via biochemical and mechanical signals in the essential developmental processes of early zebrafish embryos (e.g., mitotic wave propagation, synchronous embryo cleavages, and somitogenesis). To pin down the physical mechanisms that give rise to these complex collective phenomena, we integrate mathematical modeling, live embryo and explant imaging, nanofabrication, micro-contact printing, and systems and synthetic biology approaches.

BlueJeans livestream: https://primetime.bluejeans.com/a2m/live-event/rbuvycdc
Qiong Yang: https://medicine.umich.edu/dept/dcmb/qiong-yang-phd

3:45 pm to 4:00 pm - Light refreshments
4:00 pm - Lecture

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Lecture / Discussion Tue, 29 Oct 2019 12:56:42 -0400 2019-11-06T16:00:00-05:00 2019-11-06T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
Rich Earth Summit: Policy, Regulation, and Moving to Implementation of New Technologies (November 7, 2019 8:00am) https://events.umich.edu/event/66491 66491-16742670@events.umich.edu Event Begins: Thursday, November 7, 2019 8:00am
Location: Palmer Commons
Organized By: Civil and Environmental Engineering

A growing national team of experts is building momentum in the emerging field of study and practice of urine separation to rethink the the water-nutrient cycle. The summit's purpose is to look at how regulation can be changed to advance this work, showcase the latest developments, begin new collaborative projects and to share the enthusiasm and vast creative energies of entrepreneurs, engineers, researchers and practitioners.

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Conference / Symposium Mon, 30 Sep 2019 14:02:15 -0400 2019-11-07T08:00:00-05:00 2019-11-07T21:00:00-05:00 Palmer Commons Civil and Environmental Engineering Conference / Symposium Crops at sunrise
BME Seminar: Michael Kolios, Ph.D. (November 7, 2019 9:00am) https://events.umich.edu/event/69110 69110-17244699@events.umich.edu Event Begins: Thursday, November 7, 2019 9:00am
Location: Chrysler Center
Organized By: Biomedical Engineering

Photoacoustic imaging relies on the generation of ultrasound waves from optically absorbing structures. The physics of photoacoustic wave generation has been compared to lightning and thunder. The interest in photoacoustic imaging has been steadily growing as optical contrast can be probed deeper in tissues compared to optical methods alone, resulting in possibly one of the most exciting new biomedical imaging techniques of the decade. Ultrasound waves produced by the absorption of light in tissue can be analyzed by methods similar to those developed to analyze ultrasound backscatter signals in the field known as ultrasound tissue characterization or quantitative ultrasound. The physics of photoacoustic wave generation can help in the interpretation of the signals detected by ultrasound transducers in photoacoustics. In the absence of exogenous optical absorbers, hemoglobin in red blood cells is the primary endogenous chromophore in tissues (as melanin is predominantly confined to the skin). The spatial distribution of red blood cells, typically confined to the vasculature, determines the frequency content of the ultrasound signals produced. Analysis of the photoacoustic signals can reveal information related to the tissue vasculature. We have applied these principles to cancer treatment monitoring and other blood pathologies. Tumor blood vessels have a distinct organizational structure compared to healthy blood vessels: typical
vessel networks are hierarchically organized, with vessels that are evenly distributed to ensure adequate oxygen and nutrient delivery. Tumor vessels are structurally different: they are torturous and typically hyperpermeable. Therapies that target the vasculature can induce changes in the vascular networks that, in principle, should be detected using photoacoustic imaging. In this presentation, we will review the techniques we have developed, which depend on the analysis of the frequency content of the ultrasound photoacoustic waves. We will show how we can use this information to filter vessels according to size with high specificity (resulting in a technique we have termed F-mode) and for non-resolvable vessels, how the frequency content of the photoacoustic signals encodes information about the size, concentration and spatial distribution of blood vessels. We also show how these techniques can be used to assess treatment response and speculate how we can use photoacoustic imaging to guide drug delivery and monitor its effects on tissues.

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Lecture / Discussion Mon, 04 Nov 2019 16:27:41 -0500 2019-11-07T09:00:00-05:00 2019-11-07T10:00:00-05:00 Chrysler Center Biomedical Engineering Lecture / Discussion BME Logo
ISD Open House (November 7, 2019 12:00pm) https://events.umich.edu/event/68864 68864-17186657@events.umich.edu Event Begins: Thursday, November 7, 2019 12:00pm
Location: School of Information North
Organized By: Integrative Systems + Design

We'd love to meet you.

Are you a naturally curious, problem solving, cross-disciplinary, holistic thinking student who would like to chart the next course of your education?

If any or all of those descriptors applies to you, then please stop by during our Open House to learn about our graduate degree programs in:

Automotive Engineering
Design Science
Energy Systems Engineering
Global Automotive + Manufacturing Engineering
Manufacturing
Systems Engineering + Design

ISD staff, program directors, and other ISD students will be here to answer any questions you might have.

Stop in and stay as long as you like!

Refreshments will be provided.

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Other Mon, 28 Oct 2019 07:55:59 -0400 2019-11-07T12:00:00-05:00 2019-11-07T14:00:00-05:00 School of Information North Integrative Systems + Design Other ISD Open House
Ayyalusamy Ramamoorthy's Robert W. Parry Collegiate Professorship in Chemistry and Biophysics Lecture & Reception (November 7, 2019 4:00pm) https://events.umich.edu/event/67851 67851-16960492@events.umich.edu Event Begins: Thursday, November 7, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Physical

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Other Thu, 07 Nov 2019 18:15:22 -0500 2019-11-07T16:00:00-05:00 2019-11-07T18:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Bioscience Grad School and Career Panel (November 7, 2019 4:00pm) https://events.umich.edu/event/68919 68919-17197018@events.umich.edu Event Begins: Thursday, November 7, 2019 4:00pm
Location: Biological Sciences Building
Organized By: Futures in Research, Science, Teaching - FIRST

This panel is the opening event of the new student org FIRST: Futures in Research, Science, Teaching. If you are a student interested in non-medical science careers, or are looking for help preparing for the grad school application process, email FIRST.Contact@umich.edu to join our new org.

Panel Info
Date: Thursday, November 7th
Time: 4pm
Place: 1010 BSB

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Workshop / Seminar Tue, 29 Oct 2019 12:24:56 -0400 2019-11-07T16:00:00-05:00 2019-11-07T17:00:00-05:00 Biological Sciences Building Futures in Research, Science, Teaching - FIRST Workshop / Seminar FIRST
EEB Thursday Seminar: Carnivores - competition and connectivity (November 7, 2019 4:00pm) https://events.umich.edu/event/65477 65477-16605610@events.umich.edu Event Begins: Thursday, November 7, 2019 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Current extinction rates are comparable to five prior mass extinctions in the earth’s history, and are strongly affected by human activities that have modified more than half of the earth’s terrestrial surface. Increasing human activity restricts animal movements and isolates formerly connected populations, a particular concern for the conservation of large carnivores, but no prior research has used high throughput sequencing in a standardized manner to examine genetic connectivity for multiple species of large carnivores and multiple ecosystems. We used RAD SNP genotypes to test for differences in connectivity between multiple ecosystems for African wild dogs (Lycaon pictus) and lions (Panthera leo), and to test correlations between genetic distance, geographic distance and landscape resistance due to human activity. We found weaker connectivity and a stronger correlation between genetic distance and landscape resistance for lions, and propose a new hypothesis that adaptations to interspecific competition may help to explain differences in vulnerability to isolation by humans.

View YouTube video of seminar: https://youtu.be/ekCd9EWl5G4

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Workshop / Seminar Fri, 10 Apr 2020 14:14:28 -0400 2019-11-07T16:00:00-05:00 2019-11-07T17:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Wild dog at sunset, EEB Seminar
FIRST: Future in Research, Science, and Teaching Q&A Panel with Life/Biomedical Science Professors (November 7, 2019 4:00pm) https://events.umich.edu/event/69000 69000-17211734@events.umich.edu Event Begins: Thursday, November 7, 2019 4:00pm
Location: Biological Sciences Building
Organized By: Program in Biology

Are you interested in attending graduate school? Becoming a professor? Running a research lab and teaching? Pursuing a MS or PhD-based career?

Join us for a Q&A panel with Professors Catherine Collins, Monica Dus, Jayakrishnan (JK) Nandakumar, Anthony Vechiarelli, who are faculty members in the Department of Molecular, Cellular, and Developmental Biology.

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Careers / Jobs Thu, 31 Oct 2019 10:15:11 -0400 2019-11-07T16:00:00-05:00 2019-11-07T17:00:00-05:00 Biological Sciences Building Program in Biology Careers / Jobs FIRST Q&A Panel
MedChem Seminar (November 7, 2019 4:00pm) https://events.umich.edu/event/68815 68815-17155484@events.umich.edu Event Begins: Thursday, November 7, 2019 4:00pm
Location: Pharmacy College
Organized By: Department of Medicinal Chemistry

Trimming the C-terminal tail of alpha-tubulin: What is it good for?

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Lecture / Discussion Thu, 24 Oct 2019 13:36:22 -0400 2019-11-07T16:00:00-05:00 2019-11-07T17:00:00-05:00 Pharmacy College Department of Medicinal Chemistry Lecture / Discussion Pharmacy College
Professor Ayyalusamy Ramamoorthy, the Robert W. Parry Collegiate Professor of Chemistry and Biophysics, Inaugural Lecture (November 7, 2019 4:00pm) https://events.umich.edu/event/64420 64420-16346365@events.umich.edu Event Begins: Thursday, November 7, 2019 4:00pm
Location: Weiser Hall
Organized By: The College of Literature, Science, and the Arts

In spite of the recent developments in structural biology, membrane proteins continue to pose tremendous challenges to most biophysical techniques. A major area of research in my group has been focused on the development of NMR techniques to study the dynamic structural interactions between membrane bound proteins that are implicated in the pathology of many diseases. My lecture will focus on the approaches to overcome the major challenges related two such examples. Strategies to study atomic-resolution structure and dynamics of membrane proteins, and the dynamic molecular events enabling the enzymatic function of cytochrome P450 will be presented. Protein misfolding and amyloid aggregation, structures of early amyloid intermediates and mechanisms of amyloid induced membrane disruption related to Alzheimer’s disease and type-2 diabetes will also be discussed.

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Lecture / Discussion Thu, 10 Oct 2019 11:11:30 -0400 2019-11-07T16:00:00-05:00 2019-11-07T17:30:00-05:00 Weiser Hall The College of Literature, Science, and the Arts Lecture / Discussion Photo
Rich Earth Summit: Policy, Regulation, and Moving to Implementation of New Technologies (November 8, 2019 8:00am) https://events.umich.edu/event/66491 66491-16742671@events.umich.edu Event Begins: Friday, November 8, 2019 8:00am
Location: Palmer Commons
Organized By: Civil and Environmental Engineering

A growing national team of experts is building momentum in the emerging field of study and practice of urine separation to rethink the the water-nutrient cycle. The summit's purpose is to look at how regulation can be changed to advance this work, showcase the latest developments, begin new collaborative projects and to share the enthusiasm and vast creative energies of entrepreneurs, engineers, researchers and practitioners.

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Conference / Symposium Mon, 30 Sep 2019 14:02:15 -0400 2019-11-08T08:00:00-05:00 2019-11-08T15:00:00-05:00 Palmer Commons Civil and Environmental Engineering Conference / Symposium Crops at sunrise
U-M Structure Seminar: Ben McIlwain, Ph.D. (November 8, 2019 10:00am) https://events.umich.edu/event/66202 66202-16719581@events.umich.edu Event Begins: Friday, November 8, 2019 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

Postdoctoral Associate, Stockbridge Lab

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Lecture / Discussion Tue, 03 Sep 2019 13:43:54 -0400 2019-11-08T10:00:00-05:00 2019-11-08T11:00:00-05:00 Life Sciences Institute U-M Structural Biology Lecture / Discussion Life Sciences Institute
ISD Manufacturing Seminar Series (November 8, 2019 11:00am) https://events.umich.edu/event/68798 68798-17252891@events.umich.edu Event Begins: Friday, November 8, 2019 11:00am
Location: Chrysler Center
Organized By: Integrative Systems + Design

Join us Friday, November 8, 2019 from 11:00am-12:00pm in Chrysler Center, Room 151 (2121 Bonisteel Blvd, Ann Arbor) for our Manufacturing Seminar Series Speaker, with Xun Huan, Ph.D. Professor Huan is an Assistant Professor of Mechanical Engineering at the University of Michigan.

In this presentation, Dr. Huan will talk about finding the most useful data and how using a careful design of limited data acquisition opportunities can lead to substantial resource savings.
RSVP here: https://forms.gle/b94JCeg23jJwu3Li9

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Workshop / Seminar Tue, 05 Nov 2019 12:25:41 -0500 2019-11-08T11:00:00-05:00 2019-11-08T12:00:00-05:00 Chrysler Center Integrative Systems + Design Workshop / Seminar MFG Seminar
EEB Seminar Series: Insights into the ecology and evolution of amphibian susceptibility to chytridiomycosis in a changing world AND a vision for the U of M Biological Station (November 8, 2019 12:00pm) https://events.umich.edu/event/68572 68572-17103239@events.umich.edu Event Begins: Friday, November 8, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

The amphibian chytrid fungus, Batrachochytrium dendrobatidis (Bd) is one of several emerging pathogens identified as key threats to wildlife. In some areas of the world the introduction of Bd to naïve host communities resulted in epidemics of the disease chytridiomycosis that caused numerous declines and extinctions. Our work in western Panama, which experienced die-offs in the mid-2000s, has focused on understanding what comes after such epidemics, testing hypotheses about the roles of host and pathogen evolution in the shift to endemic dynamics, or the persistence of host and pathogen in a shared environment. Another focus of my lab’s efforts has been on clarifying how both current (i.e., seasonal) and predicted future changes in climate shape the risk of disease related declines in North American frogs. Using a combination of field studies and experiments, we have begun to clarify the effect of temperature on host immune defenses and susceptibility to chytridiomycosis, and how the opportunity for thermally-mediated host defense varies in space and time. Using mesocosm studies, we are also investigating how climate-induced stress experienced during larval development impacts later life traits, like immune defense and thermal tolerance, that affect fitness in a broader context.
The University of Michigan Biological Station (UMBS) is a tremendous resource, with strengths in research, education and community engagement. Drawing on my experience as a field station researcher and director, I’ll conclude my seminar by outlining my vision for the future of the UMBS. Here I’ll highlight ways we can build upon the station’s existing strengths to promote more collaborative and interdisciplinary research, demonstrate excellence in place-based teaching and learning, and strengthen interactions between field station users and both the U of M and Northern Michigan communities.
Image by Ashley Cecil

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Workshop / Seminar Wed, 06 Nov 2019 11:14:47 -0500 2019-11-08T12:00:00-05:00 2019-11-08T13:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Zawacki ecology and evolution of amphibian susceptibility
MCDB Seminar: Cellular Pathways Regulating Early Pollen-Pistil Interactions and Self-Fertility (November 8, 2019 12:00pm) https://events.umich.edu/event/67360 67360-16839926@events.umich.edu Event Begins: Friday, November 8, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Cora MacAlister

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Workshop / Seminar Tue, 17 Sep 2019 16:38:38 -0400 2019-11-08T12:00:00-05:00 2019-11-08T13:00:00-05:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar close up photo of flower with parts labelled
Human Genetics 2019 Seminar Series (November 8, 2019 4:00pm) https://events.umich.edu/event/69264 69264-17277394@events.umich.edu Event Begins: Friday, November 8, 2019 4:00pm
Location: Buhl Res Cen for Human Genetics
Organized By: Human Genetics

"Neurofibromatosis type1: deconvoluting germline genetics"
David Gutmann, M.D., Ph.D.
Donald O. Schnuck Family Professor
Vice Chair for Research Affairs
Department of Neurology
Director, Neurofibromatosis
Washington University School of Medicine

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Other Fri, 08 Nov 2019 12:27:51 -0500 2019-11-08T16:00:00-05:00 2019-11-08T17:00:00-05:00 Buhl Res Cen for Human Genetics Human Genetics Other dhg logo 2
Personalizing treatment in cardiovascular diseases (November 11, 2019 12:00pm) https://events.umich.edu/event/67329 67329-16839870@events.umich.edu Event Begins: Monday, November 11, 2019 12:00pm
Location: 1100 North University Building
Organized By: Precision Health

Listen to a presentation on personalized treatments in cardiovascular disease given by Simon de Denus, the Beaulieu-Saucier Chair in Pharmacogenomics at the Université de Montréal, whose research and teaching interests are in the areas of cardiovascular pharmacotherapy and personalized medicine.

He completed his Bachelor of Pharmacy at the Université de Montréal (UdeM) in 1999 and completed his MSc in hospital pharmacy practice at the Université de Montréal in 2000. He then completed a residency in cardiovascular pharmacotherapy at the Hôpital du Sacré-Coeur in Montreal and then a Fellowship at the University of the Sciences in Philadelphia. De Denus obtained his PhD in pharmaceutical sciences from UdeM. He is a Professor at the Faculty of Pharmacy of UdeM, as well as a pharmacist and researcher at the Montreal Heart Institute. He has published over 80 articles in journals such *Chest*, *Archives of Internal Medicine*, *Pharmacogenomics Journal*, *Circulation: Cardiovascular Genetics*, *American Heart Journal*, and the *New England Journal of Medicine*. He has also authored more than 15 book chapters.

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Presentation Tue, 17 Sep 2019 12:31:02 -0400 2019-11-11T12:00:00-05:00 2019-11-11T13:00:00-05:00 1100 North University Building Precision Health Presentation Simon de Denus
MCDB Defense: Investigations of the Root Epidermal Cell Specification in Arabidopsis thaliana (November 11, 2019 1:30pm) https://events.umich.edu/event/69127 69127-17250862@events.umich.edu Event Begins: Monday, November 11, 2019 1:30pm
Location: Rackham Graduate School (Horace H.)
Organized By: Department of Molecular, Cellular, and Developmental Biology

Mentor: John Schielfelbein

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Workshop / Seminar Tue, 05 Nov 2019 11:52:54 -0500 2019-11-11T13:30:00-05:00 2019-11-11T15:30:00-05:00 Rackham Graduate School (Horace H.) Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar microscope images and MCDB
RNA Innovation Seminar, Bruce Sullenger, Duke School of Medicine (November 11, 2019 4:00pm) https://events.umich.edu/event/65141 65141-16539451@events.umich.edu Event Begins: Monday, November 11, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Bruce A. Sullenger, Ph.D.
Joseph and Dorothy Beard Professor
Department of Surgery
Professor of Pharmacology and Cancer Biology
Duke University Medical Center

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Lecture / Discussion Thu, 24 Oct 2019 08:30:39 -0400 2019-11-11T16:00:00-05:00 2019-11-11T17:00:00-05:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion flyer
EEB Tuesday Lunch Seminar/student evaluation: The biogeography of cichlids in the Guianas: insights into contemporary and historical drivers of diversity and endemism in Neotropical rivers (November 12, 2019 12:00pm) https://events.umich.edu/event/65004 65004-16501303@events.umich.edu Event Begins: Tuesday, November 12, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Please join us for our weekly brown bag lunch seminar

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Workshop / Seminar Tue, 05 Nov 2019 13:14:25 -0500 2019-11-12T12:00:00-05:00 2019-11-12T13:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Diagram showing map of South America, fish phylogenies
Hypoxia and Mitochondrial Disease: Can Two Wrongs Make a Right?- George William Jourdian Lectureship in Biological Chemistry (November 12, 2019 12:00pm) https://events.umich.edu/event/68289 68289-17043839@events.umich.edu Event Begins: Tuesday, November 12, 2019 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Vamsi Mootha, Professor of Systems Biology at Harvard Medical School and Professor of Medicine at Massachusetts General Hospital, will present the 3rd Annual George William Jourdian Lectureship in Biological Chemistry On Tuesday November 12th, 2019 at 12 noon in North Lecture Hall, MS II

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Lecture / Discussion Fri, 11 Oct 2019 08:37:52 -0400 2019-11-12T12:00:00-05:00 2019-11-12T13:00:00-05:00 Medical Science Unit II Biological Chemistry Lecture / Discussion Mootha
Student evaluation seminar: A tale of two dewlaps: the evolution of a colorful signal in Anolis lizards (November 12, 2019 3:00pm) https://events.umich.edu/event/68865 68865-17186663@events.umich.edu Event Begins: Tuesday, November 12, 2019 3:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

John David presents his preliminary seminar.

Image credit: John David Curlis

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Workshop / Seminar Mon, 28 Oct 2019 10:59:57 -0400 2019-11-12T15:00:00-05:00 2019-11-12T16:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Two anolis lizards on branches facing each other with yellow and white dewlaps extended, black background.
Genomic insights into human cortical development (November 12, 2019 4:00pm) https://events.umich.edu/event/68647 68647-17130514@events.umich.edu Event Begins: Tuesday, November 12, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for Cell Plasticity and Organ Design

2019-2020 Center for Organogenesis Seminar Series
Faculty Host(s): Jack Parent, Ken Kwan, Shigeki Iwase
For additional info contact: organogenesis@umich.edu

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Lecture / Discussion Mon, 21 Oct 2019 12:35:14 -0400 2019-11-12T16:00:00-05:00 2019-11-12T17:00:00-05:00 Taubman Biomedical Science Research Building Center for Cell Plasticity and Organ Design Lecture / Discussion Kriegstein Flyer
Human Genetics 2019 Seminar Series (November 12, 2019 4:00pm) https://events.umich.edu/event/69264 69264-17275362@events.umich.edu Event Begins: Tuesday, November 12, 2019 4:00pm
Location: Buhl Res Cen for Human Genetics
Organized By: Human Genetics

"Neurofibromatosis type1: deconvoluting germline genetics"
David Gutmann, M.D., Ph.D.
Donald O. Schnuck Family Professor
Vice Chair for Research Affairs
Department of Neurology
Director, Neurofibromatosis
Washington University School of Medicine

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Other Fri, 08 Nov 2019 12:27:51 -0500 2019-11-12T16:00:00-05:00 2019-11-12T17:00:00-05:00 Buhl Res Cen for Human Genetics Human Genetics Other dhg logo 2
U-M Biological Station Prospective Student Information Session (November 12, 2019 4:00pm) https://events.umich.edu/event/65757 65757-16653999@events.umich.edu Event Begins: Tuesday, November 12, 2019 4:00pm
Location: Dana Natural Resources Building
Organized By: University of Michigan Biological Station

Prospective students: Come learn about how to earn credits, gain research experience, and have the spring/summer of your life at UMBS. Featuring a student panel, dates & deadlines, and financial aid information.

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Rally / Mass Meeting Mon, 26 Aug 2019 14:22:27 -0400 2019-11-12T16:00:00-05:00 2019-11-12T17:00:00-05:00 Dana Natural Resources Building University of Michigan Biological Station Rally / Mass Meeting Students enjoy a canoe ride on Douglas Lake at the U-M Biological Station.
CDB Seminar: Defining the role of ER-associated degradation in health and disease (November 13, 2019 9:30am) https://events.umich.edu/event/68707 68707-17138827@events.umich.edu Event Begins: Wednesday, November 13, 2019 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

2019 Cell & Developmental Biology Seminar Series

Hosted By: Qing Li, MD

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Lecture / Discussion Mon, 28 Oct 2019 15:56:34 -0400 2019-11-13T09:30:00-05:00 2019-11-13T10:30:00-05:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion CDB Seminar - Qi
Design Science Information Session (November 13, 2019 3:30pm) https://events.umich.edu/event/68997 68997-17211732@events.umich.edu Event Begins: Wednesday, November 13, 2019 3:30pm
Location: Duderstadt Center
Organized By: Integrative Systems + Design

This information session will give you a better understanding of what the Design Science degree can do for you, as well as allow you to ask questions from our Program Chair, and current Design Science students.

Design Science offers a MS and PhD option.

Please RSVP here: https://forms.gle/tDjvoG6zYmUizqtz7

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Workshop / Seminar Thu, 31 Oct 2019 09:32:02 -0400 2019-11-13T15:30:00-05:00 2019-11-13T16:30:00-05:00 Duderstadt Center Integrative Systems + Design Workshop / Seminar Duderstadt Center
Department of Computational Medicine & Bioinformatics Seminar (November 13, 2019 4:00pm) https://events.umich.edu/event/68641 68641-17128443@events.umich.edu Event Begins: Wednesday, November 13, 2019 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Talk Title: Reproducibility with high-dimensional data

Abstract: With the expanding generation of large-scale biological datasets, there has been an ever-greater concern in understanding the reproducibility of discoveries and findings in a statistically reliable manner. We review several concepts in reproducibility and describe how one can adopt a multiple testing perspective on the problem. This leads to an intuitive procedure for assessing reproducibility. We demonstrate application of the methodology using RNA-sequencing data as well as metabolomics datasets. We will also outline some further problems in the field.

This is joint work with Daisy Philtron, Yafei Lyu and Qunhua Li (Penn State) and Tusharkanti Ghosh, Weiming Zhang and Katerina Kechris (University of Colorado).

DCMB Faculty Host: Alla Karnovsky, PhD

3:45 p.m. - Light Refreshments
4:00 p.m. - Lecture

BlueJeans Live Streaming: https://primetime.bluejeans.com/a2m/live-event/rbuvycdc

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Lecture / Discussion Mon, 21 Oct 2019 11:05:22 -0400 2019-11-13T16:00:00-05:00 2019-11-13T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion