Happening @ Michigan https://events.umich.edu/list/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. NO EEB Tuesday Lunch Seminar today (March 3, 2020 12:00pm) https://events.umich.edu/event/69219 69219-17269223@events.umich.edu Event Begins: Tuesday, March 3, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Tuesday Lunch Seminars return on March 10, 2020.

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Workshop / Seminar Thu, 07 Nov 2019 12:45:24 -0500 2020-03-03T12:00:00-05:00 2020-03-03T13:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Biological Sciences Building background, UM EEB logo and text reading EEB Tuesday Lunch Seminars
“Engineered kidney models derived from human induced pluripotent stem cells” (March 3, 2020 4:00pm) https://events.umich.edu/event/73334 73334-18199520@events.umich.edu Event Begins: Tuesday, March 3, 2020 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for Cell Plasticity and Organ Design

The NIH T32 Training Program in Organogenesis is pleased to present a Special Series: "Emerging Topics in Tissue Regeneration and Engineering" featuring seminar guest Samira Musah, Ph.D.

Dr. Musah is an Assistant Professor, Biomedical Engineering, Department of Medicine, Duke University.

The talk is entitled, “Engineered kidney models derived from human induced pluripotent stem cells.”

Trainee Host: Eun-Kyeoung Choi, Ph.D.-The Seo Lab

For additional info: 936-2499 / organogenesis@umich.edu

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Lecture / Discussion Wed, 26 Feb 2020 14:19:07 -0500 2020-03-03T16:00:00-05:00 2020-03-03T17:00:00-05:00 Taubman Biomedical Science Research Building Center for Cell Plasticity and Organ Design Lecture / Discussion Musah Flyer
Comprehensive Understanding of Material Characteristics of Perfluoroalkyl Compounds Studied by Vibrational Spectroscopy (March 4, 2020 4:00pm) https://events.umich.edu/event/72033 72033-17916362@events.umich.edu Event Begins: Wednesday, March 4, 2020 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Organofluorine compounds represented by perfluoroalkyl (Rf) compounds involving polytetrafluoroethylene (PTFE) attract keen interest for various practical chemistry fields such as material science and pharmaceutical science. Research of organofluorine compounds, however, has long been oriented to organic synthesis, and physicochemical background is still weak to fully understand the material property on the primary chemical structure. Recently, the Stratified Dipole-Arrays (SDA) theory [Chem. Rec. 2017, 17, 903.] has been published, which comprehensively explains various Rf compound-specific properties for both macroscopic and microscopic properties. On this theory, quantitative analysis of the molecular aggregation and orientation is being developed by using infrared and Raman spectroscopy. Multiple-angle incidence resolution spectrometry (MAIRS) coupled with FT-IR readily reveals the perfectly perpendicular orientation of a compound having an Rf chain with a length of (CF2)7 or longer in the two-dimensional molecular aggregate, i.e., a thin film. On the SDA theory, each molecular aggregate should be consisted of one of the right- or left-handed helical Rf chains. This means that the molecular domain of an Rf compound should exhibit Raman optical activity (ROA) even if the compound has no chiral center. In fact, our measurements of ROA on a single crystal of a Rf compound apparent ROA signal [J. Phys. Chem. 2019, 123, 3985.]. In this manner, vibrational spectroscopy works as a powerful tool to reveal the fine chemical structure of molecular aggregation of Rf compounds. For the full understanding, however, a conventional concept for hydrocarbons must be changed, since the relative mass of fluorine to carbon is overturned to the case of hydrogen to carbon. In the talk, fundamental details of vibrational spectroscopy on the SDA theory are presented in a comprehensive manner.









Takeshi Hasegawa (Kyoto University)

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Other Wed, 04 Mar 2020 18:15:51 -0500 2020-03-04T16:00:00-05:00 2020-03-04T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
How to make a stem cell: Gene regulatory principles learned from vascular fate transitions (March 5, 2020 3:00pm) https://events.umich.edu/event/72083 72083-17937811@events.umich.edu Event Begins: Thursday, March 5, 2020 3:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

We are pleased to welcome Dionna M. Kasper, Ph.D., Post-Doctoral Fellow, Yale University School of Medicine to the Kahn Auditorium in BSRB on Thursday, March 5, 2020.

Hosted by: CDB Recruitment Committee

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Lecture / Discussion Mon, 03 Feb 2020 09:49:59 -0500 2020-03-05T15:00:00-05:00 2020-03-05T16:00:00-05:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion How to make a stem cell: Gene regulatory principles learned from vascular fate transitions
BME 500: Ruobo Zhou (March 5, 2020 4:00pm) https://events.umich.edu/event/73399 73399-18214945@events.umich.edu Event Begins: Thursday, March 5, 2020 4:00pm
Location: Industrial and Operations Engineering Building
Organized By: Biomedical Engineering

Biomolecular interactions are at the root of all biological processes and define the molecular mechanisms of how these processes are accomplished in both physiological and pathological conditions. Recent advances in single molecule detection and super-resolution fluorescence microcopy have uncovered previously unknown properties of biomolecular interactions, including multivalency, transiency, and heterogeneity, and revealed the organizational principles governing the compartmentalization of functional biomolecular interactions in cells and how such compartmentalization and organizations become dysregulated in diseases. In this talk, I will first discuss my postdoctoral work, where I used mass-spectrometry-based analysis and super-resolution imaging to dissect the protein-protein interactions at the plasma membrane of neurons, and discovered that a newly identified membrane-associated periodic skeleton (MPS) structure can function as a signaling platform that coordinates the interactions of signaling proteins at the plasma membrane of neurons. In response to extracellular stimuli, G-protein coupled receptors, cell-adhesion molecules, receptor tyrosine kinases can be recruited to the MPS to form signaling complexes at the plasma membrane, and such recruitment is required for downstream intracellular signaling. This work not only reveals an important, previously unknown function of the newly discovered MPS structure, but also provides novel mechanistic insights into signal transduction in neurons. I will then discuss my graduate work, where I developed a hybrid single molecule technique combining single molecule FRET and optical tweezers, and applied this technique to probe the sub-molecular dynamics of protein-DNA interactions in various biological systems involved in DNA replication, repair and recombination.

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Lecture / Discussion Fri, 28 Feb 2020 11:07:38 -0500 2020-03-05T16:00:00-05:00 2020-03-05T17:00:00-05:00 Industrial and Operations Engineering Building Biomedical Engineering Lecture / Discussion BME Logo
RNP Granules in Health and Disease (March 9, 2020 4:00pm) https://events.umich.edu/event/65593 65593-16621787@events.umich.edu Event Begins: Monday, March 9, 2020 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Eukaryotic cells contain multiple assemblies of RNA and protein referred to as RNP granules, or RNP condensates. In the cytosol, ubiquitous RNP granules include stress granules, which form when translation initation is limited, and P-bodies, which are constitutive RNP granules containing mRNAs and the RNA decay machinery. Both stress granules and P-bodies contain complex proteomes and transcriptomes and their assembly/disassembly are regulated by diverse RNP remodeling complexes.
Focusing on stress granules, we have provided evidence that stress granule, and presumably other RNP condensate, assembly occurs in part through intermolecular RNA-RNA interactions. However, based on in vitro studies, we demonstrate that RNA condensation should be expected to be a thermodynamically favored process in cells. This argues cells must contain mechanisms to limit RNA driven condensation. We have demonstrated that abundant RNA helicase reduces RNA recruitment to RNA condensates in vitro and in cells, as well as limiting stress granule formation. This defines a new function for abundant RNA helicases to limit thermodynamically favored intermolecular RNA-RNA interactions in cells as “RNA decondenases”, thereby allowing proper RNP function.










Roy Parker (HHMI/Univ of Colorado Boulder)

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Other Mon, 02 Mar 2020 12:15:46 -0500 2020-03-09T16:00:00-04:00 2020-03-09T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Epidemiology and dynamics of the coronavirus (COVID-19) epidemic (March 10, 2020 11:30am) https://events.umich.edu/event/73197 73197-18157926@events.umich.edu Event Begins: Tuesday, March 10, 2020 11:30am
Location: Weiser Hall
Organized By: The Center for the Study of Complex Systems

The novel coronavirus COVID-19 epidemic is currently leveling off in China but on the upswing in the rest of the world. Understanding and modeling this growth is obviously of high importance. We noticed that for several weeks, the number of deaths in China could be fit by a power law with exponent of about 2.25, suggesting a kind of fractal or small-world behavior going on. Traditional epidemiological models, such as the Susceptible-Exposed-Infected-Recovered models (SEIR) puts groups in compartments and use differential equations to predict the behavior, but there is no spatial or network properties taken into account. At early times, the growth is exponential depending upon the reproduction rate, and for later times those models predict an s-shaped curve. The power-law result predicted a greater growth of the epidemic than many people were predicting. More recently, the daily deaths in China have dropped off exponentially, in fact following a model of A. Vazquez from 2006. At the same time, the growth in the number of total deaths in other parts of the world is tracking the behavior in China, delayed by one month. The small-world, fractal idea suggested that this world-wide transmission was likely to take place, and the belief that it could be contained in China was clearly short-sighted.

Reference: A. L. Ziff and R. M. Ziff, medrXiv 2020 submitted.

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Workshop / Seminar Tue, 03 Mar 2020 23:51:52 -0500 2020-03-10T11:30:00-04:00 2020-03-10T13:00:00-04:00 Weiser Hall The Center for the Study of Complex Systems Workshop / Seminar Robert Ziff
Questioning Assumptions in Lewis Acid Catalysis (March 10, 2020 11:45am) https://events.umich.edu/event/69375 69375-17312377@events.umich.edu Event Begins: Tuesday, March 10, 2020 11:45am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The interactions between Lewis acids and carbonyls have played a significant role in the construction of important molecules. While a great deal of insight has been gained regarding classical stoichiometric regimes, more discoveries continue to be made about the complexities of these interactions between carbonyls and Lewis acids in catalytic systems. In particular, the new reactivity observed in Lewis acid-catalyzed carbonyl-olefin metathesis demonstrates that a comprehensive understanding of the interactions between these classical Lewis pairs remains incomplete. It is our hypothesis that the application of in situ techniques will provide key insights into reactivity initiated by the interactions of Lewis pairs that are as yet unexplored. Synthetic, spectroscopic, kinetic, and computational techniques will be presented which facilitate characterization of both the ground and transition state behavior of Lewis acids and carbonyl compounds. These data will be used to demonstrate the complex interplay of Lewis acid catalyst, substrate, and product under synthetically relevant conditions. Overall, these rigorous mechanistic studies catalogue the factors critical to concise reaction design, and more specifically, detail the mechanistic features of carbonyl-olefin metathesis.




James Devery (Loyola University Chicago)

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Other Tue, 10 Mar 2020 18:15:54 -0400 2020-03-10T11:45:00-04:00 2020-03-10T13:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
EEB Tuesday Lunch Seminar: The origin of baleen in whales: inferring soft tissue from bony structures (March 10, 2020 12:00pm) https://events.umich.edu/event/69220 69220-17269224@events.umich.edu Event Begins: Tuesday, March 10, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Please join us for our weekly brown bag lunch seminar.

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Workshop / Seminar Fri, 28 Feb 2020 10:03:10 -0500 2020-03-10T12:00:00-04:00 2020-03-10T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Carlos Peredo working on fossilized bone
Forum on "Climate Change and Health: Readiness and Resilience" (March 10, 2020 12:00pm) https://events.umich.edu/event/72763 72763-18070598@events.umich.edu Event Begins: Tuesday, March 10, 2020 12:00pm
Location: Towsley Center for Cont. Med Ed
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

*Please register by going to http://mleead.umich.edu/Event_Climate_Change_and_Health_2020.php*

Our climate is our planet’s life support system. Climate change influences human health and disease in numerous ways, including impacts from increased extreme weather events, wildfire, decreased air quality, and illnesses transmitted by food, water, and disease carriers such as mosquitoes and ticks. As described in the Lancet Countdown report, some existing health threats will intensify and new health threats will emerge. Not everyone is equally at risk, and children are especially at risk. Preventive and adaptive actions are needed.

The keynote speaker is an emergency medicine physician who co-authored the U.S. portion of the Lancet Countdown report and Health and Care Delivery in the New England Journal of Medicine. A panel of experts will present solutions from a variety of other universities who are reducing their carbon footprint in response to the urgent public health need.

Welcome: Joseph C. Kolars, MD, Senior Associate Dean for Education and Global Initiatives, UM Medical School

Keynote: "Climate Action: Children’s Health Drives Need for Urgent Action" Renee N. Salas, MD, MPH, MS, Clinical Instructor of Emergency Medicine, Harvard Medical School and emergency medicine physician, Massachusetts General Hospital

Schedule
11:00-11:45 am | Registration outside of Dow Auditorium, Towsley Center for Continuing Medical Education, Michigan Medicine
11:00-11:45 am | Lunch in Towsley Center Dining Room for registered guests
12:00-1:30 pm | Program in Dow Auditorium, Towsley Center (also will be live streamed)
1:30-2:00 pm | Reception in Towsley Center Dining Room

*Please register by going to http://mleead.umich.edu/Event_Climate_Change_and_Health_2020.php*

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Conference / Symposium Fri, 21 Feb 2020 13:52:24 -0500 2020-03-10T12:00:00-04:00 2020-03-10T13:30:00-04:00 Towsley Center for Cont. Med Ed Michigan Lifestage Environmental Exposures and Disease Center Conference / Symposium Climate Change and Health: Readiness and Resilience