Happening @ Michigan https://events.umich.edu/list/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (July 23, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656649@events.umich.edu Event Begins: Monday, July 23, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-07-23T14:00:00-04:00 2018-07-23T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (July 24, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656560@events.umich.edu Event Begins: Tuesday, July 24, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-07-24T14:00:00-04:00 2018-07-24T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (July 25, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656604@events.umich.edu Event Begins: Wednesday, July 25, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-07-25T14:00:00-04:00 2018-07-25T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (July 30, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656650@events.umich.edu Event Begins: Monday, July 30, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-07-30T14:00:00-04:00 2018-07-30T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Saltiel Life Sciences Symposium (July 31, 2018 12:00pm) https://events.umich.edu/event/51048 51048-13332417@events.umich.edu Event Begins: Tuesday, July 31, 2018 12:00pm
Location: Off Campus Location
Organized By: Life Sciences Institute (LSI)

Schedule:

8:45 a.m. | Welcome by U-M Provost and Executive Vice President for Academic Affairs Martin Philbert and LSI Director Roger Cone

8:55 a.m. | Introduction of the Mary Sue and Kenneth Coleman Life Sciences Lecturer
Alan R. Saltiel, Ph.D.
Director, Institute for Diabetes and Metabolic Health, and Professor, University of California, San Diego School of Medicine; Director, Life Sciences Institute 2002-2015

9:00 a.m. | Mary Sue and Kenneth Coleman Life Sciences Lecture — Single cell genomics: When stochasticity meets precision
Xiaoliang Sunney Xie, Ph.D.
Lee Shau-kee Chair Professor, Director of the Biodynamic Optical Imaging Center and Director of the Beijing Advanced Innovation Center for Genomics, Peking University

9:50 a.m. | Morning break

10:10 a.m. | Solving biomedical challenges through single cell genomics approaches
Alexandra-Chloé Villani, Ph.D.
Principal Investigator and Director, Single Cell Genomics Research Program, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital; Member of the Faculty of Medicine, Harvard Medical School; Assistant Scientist, Broad Institute of MIT and Harvard

11:00 a.m. | Exploring the biological basis of neuronal identity and diversity: From transcription mechanism to circuit function
Z. Josh Huang, Ph.D.
Charles and Marie Robertson Professor of Neuroscience, Cold Spring Harbor Laboratory

11:50 a.m. | Poster session and lunch

1:20 p.m. | Spatial genomics and single cell lineage dynamics by seqFISH and MEMOIR
Long Cai, Ph.D.
Professor of Biology and Biological Engineering, Division of Biology and Biological Engineering, California Institute of Technology

2:10 p.m. | Analytics of single cell RNA-SEQ: Lessons from heterogeneity of immune cells
Nir Yosef, Ph.D.
Assistant Professor, Department of Electrical Engineering & Computer Science, University of California, Berkeley

3:00 p.m. | Afternoon break

3:20 p.m. |Myeloid cell contribution to tumor outcome
Miriam Merad, M.D., Ph.D.
Professor and Director of the Precision Immunology Institute, Department of Oncological Sciences and Medicine, Icahn School of Medicine at Mount Sinai

4:10 p.m. | Closing remarks

Thank you to this year's external sponsors: 10x Genomics, Illumina and RareCyte

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Conference / Symposium Wed, 29 Aug 2018 07:19:05 -0400 2018-07-31T12:00:00-04:00 2018-07-31T13:00:00-04:00 Off Campus Location Life Sciences Institute (LSI) Conference / Symposium 2018 Saltiel Life Sciences Symposium
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (July 31, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656561@events.umich.edu Event Begins: Tuesday, July 31, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-07-31T14:00:00-04:00 2018-07-31T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (August 1, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656605@events.umich.edu Event Begins: Wednesday, August 1, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-08-01T14:00:00-04:00 2018-08-01T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Alum|NUM Pre-Karle Symposium Alumni Event (August 2, 2018 12:00pm) https://events.umich.edu/event/52786 52786-13079502@events.umich.edu Event Begins: Thursday, August 2, 2018 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Alumni Networking at the University of Michigan (Alum|NUM), a half-day event which connects Chemistry Department alumni with current graduate students and post-docs

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Reception / Open House Mon, 02 Jul 2018 09:41:07 -0400 2018-08-02T12:00:00-04:00 2018-08-02T18:00:00-04:00 Chemistry Dow Lab Department of Chemistry Reception / Open House save the date image
Saltiel Life Sciences Symposium (August 2, 2018 2:00pm) https://events.umich.edu/event/51048 51048-13349556@events.umich.edu Event Begins: Thursday, August 2, 2018 2:00pm
Location: Off Campus Location
Organized By: Life Sciences Institute (LSI)

Schedule:

8:45 a.m. | Welcome by U-M Provost and Executive Vice President for Academic Affairs Martin Philbert and LSI Director Roger Cone

8:55 a.m. | Introduction of the Mary Sue and Kenneth Coleman Life Sciences Lecturer
Alan R. Saltiel, Ph.D.
Director, Institute for Diabetes and Metabolic Health, and Professor, University of California, San Diego School of Medicine; Director, Life Sciences Institute 2002-2015

9:00 a.m. | Mary Sue and Kenneth Coleman Life Sciences Lecture — Single cell genomics: When stochasticity meets precision
Xiaoliang Sunney Xie, Ph.D.
Lee Shau-kee Chair Professor, Director of the Biodynamic Optical Imaging Center and Director of the Beijing Advanced Innovation Center for Genomics, Peking University

9:50 a.m. | Morning break

10:10 a.m. | Solving biomedical challenges through single cell genomics approaches
Alexandra-Chloé Villani, Ph.D.
Principal Investigator and Director, Single Cell Genomics Research Program, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital; Member of the Faculty of Medicine, Harvard Medical School; Assistant Scientist, Broad Institute of MIT and Harvard

11:00 a.m. | Exploring the biological basis of neuronal identity and diversity: From transcription mechanism to circuit function
Z. Josh Huang, Ph.D.
Charles and Marie Robertson Professor of Neuroscience, Cold Spring Harbor Laboratory

11:50 a.m. | Poster session and lunch

1:20 p.m. | Spatial genomics and single cell lineage dynamics by seqFISH and MEMOIR
Long Cai, Ph.D.
Professor of Biology and Biological Engineering, Division of Biology and Biological Engineering, California Institute of Technology

2:10 p.m. | Analytics of single cell RNA-SEQ: Lessons from heterogeneity of immune cells
Nir Yosef, Ph.D.
Assistant Professor, Department of Electrical Engineering & Computer Science, University of California, Berkeley

3:00 p.m. | Afternoon break

3:20 p.m. |Myeloid cell contribution to tumor outcome
Miriam Merad, M.D., Ph.D.
Professor and Director of the Precision Immunology Institute, Department of Oncological Sciences and Medicine, Icahn School of Medicine at Mount Sinai

4:10 p.m. | Closing remarks

Thank you to this year's external sponsors: 10x Genomics, Illumina and RareCyte

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Conference / Symposium Wed, 29 Aug 2018 07:19:05 -0400 2018-08-02T14:00:00-04:00 2018-08-02T15:00:00-04:00 Off Campus Location Life Sciences Institute (LSI) Conference / Symposium 2018 Saltiel Life Sciences Symposium
Karle Symposium (August 3, 2018 8:00am) https://events.umich.edu/event/52649 52649-12916811@events.umich.edu Event Begins: Friday, August 3, 2018 8:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Learn about the exciting research at Michigan Chemistry through this graduate student organized event -- featuring our talented students as speakers and at poster sessions.

The key note speaker is Prof. Malika Jefferies-EL, Boston University, on "Design and Synthesis of Organic Semiconductors for Advanced Applications".

Also there will be plenary industrial talks by Dow and PPG, who provide travel awards to students. The Dow speaker is Dr. Jodi Mecca on "High Throughput Coatings at Dow: Challenging Paradigms through Experimentation and Fundamental Science" and the PPG speaker is Dr. Steven R. Zawacky who will be speaking on "Making a Greener Catalyst for Electrodeposited Organic Coatings."

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Conference / Symposium Wed, 13 Jun 2018 15:40:51 -0400 2018-08-03T08:00:00-04:00 2018-08-03T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Conference / Symposium logo block with K and 20 18
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (August 6, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656651@events.umich.edu Event Begins: Monday, August 6, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-08-06T14:00:00-04:00 2018-08-06T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (August 7, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656562@events.umich.edu Event Begins: Tuesday, August 7, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-08-07T14:00:00-04:00 2018-08-07T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (August 8, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656606@events.umich.edu Event Begins: Wednesday, August 8, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-08-08T14:00:00-04:00 2018-08-08T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
BME PhD Defense: Sydney Williams (August 9, 2018 10:00am) https://events.umich.edu/event/53244 53244-13321606@events.umich.edu Event Begins: Thursday, August 9, 2018 10:00am
Location: Lurie Robert H. Engin. Ctr
Organized By: Biomedical Engineering

Constrained and Spectral-Spatial RF Pulse Design for Magnetic Resonance Imaging



Magnetic resonance imaging (MRI) is a critical tool for modern medicine, providing a non-invasive glimpse inside the human body with excellent soft tissue contrast and no ionizing radiation. The radio frequency (RF) pulse in an MRI acquisition is integral to producing an image and can be tailored to particular applications. This thesis focuses on the design of RF pulses and explores the MRI physics, convex optimization problems, and experimental methodologies behind doing so.



First, we introduce constrained RF pulse design which enables efficient RF pulse design with meaningful, physical constraints such as peak RF amplitude and integrated RF power. We explore constrained RF pulse design for simultaneous multislice imaging, a powerful tool for accelerating MRI and combatting notoriously long acquisition times. Compared to a conventional simultaneous multislice pulse designed without constraints, our constrained pulses achieved lower magnitude normalized root mean squared error (NRMSE) for an equivalent RF pulse length, or alternatively, the same NRMSE for a shorter pulse length. Constrained RF pulse design forms a basis for the rest of the dissertation.



Secondly, we describe a special class of RF pulses, “prewinding pulses”, that help correct for intravoxel dephasing due to magnetic field inhomogeneity, that can lead to signal loss. We propose a spectral-spatial prewinding pulse that leverages a larger effective recovery bandwidth than equivalent, purely spectral pulses. In an in vivo experiment imaging the brain of a human volunteer, we designed spectral-spatial pulses with a complex NMRSE of 0.18, which is significantly improved from the complex NRMSE of 0.54 in the purely spectral pulse for the same experiment.



Finally, we consider a slab-selective prewinding pulse, that extends spectral and spectral-spatial prewinding pulses to a common 3D imaging method. Here we integrate optimal control optimization to further improve the slab-selective spectral pulse design and see an in vivo improvement of excitation NRMSE from 0.40 to 0.37 and a major reduction in mean residual magnetization magnitude after a tip-up pulse from 0.18 to 0.02 when adding optimal control. This method has the potential to connect prewinding pulse design from the MRI physicist engineering workspace to a clinical application.

In summary, we show that constrained RF pulse design provides an efficient way of improving MRI in terms of acquisition speed (via multislice imaging) and image quality (via signal recovery).

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Presentation Mon, 06 Aug 2018 10:05:33 -0400 2018-08-09T10:00:00-04:00 2018-08-09T11:00:00-04:00 Lurie Robert H. Engin. Ctr Biomedical Engineering Presentation BME-EVENT Placeholder
Necessity is the Mother of Invention: Natural Products and the Chemistry They Inspire (August 10, 2018 3:00pm) https://events.umich.edu/event/47915 47915-11121025@events.umich.edu Event Begins: Friday, August 10, 2018 3:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The chemical synthesis of natural products provides an exciting platform from which to conduct fundamental research in chemistry and biology. Our group is currently pursuing the synthesis of a number of structurally complex natural products, including the diterpenoids ryanodine, talatisamine, and pleuromutilin. The densely-packed arrays of heteroatoms and stereogenic centers that constitute these polycyclic targets challenge the limits of current technology and inspire the development of new synthetic strategies and tactics. This seminar will describe the latest progress in our methodological and target-directed synthesis endeavors.









Sarah Reisman (Caltech)

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Other Tue, 24 Jul 2018 06:15:17 -0400 2018-08-10T15:00:00-04:00 2018-08-10T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (August 13, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656652@events.umich.edu Event Begins: Monday, August 13, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-08-13T14:00:00-04:00 2018-08-13T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (August 14, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656563@events.umich.edu Event Begins: Tuesday, August 14, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-08-14T14:00:00-04:00 2018-08-14T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (August 15, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656607@events.umich.edu Event Begins: Wednesday, August 15, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-08-15T14:00:00-04:00 2018-08-15T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Thesis Defense: Protein Cross-linking Capillary and Microchip Electrophoresis for Protein- Protein Interaction Analysis (August 17, 2018 3:00pm) https://events.umich.edu/event/53780 53780-13461537@events.umich.edu Event Begins: Friday, August 17, 2018 3:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Claire Ouimet (Advisor: Prof. Robert Kennedy)

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Other Fri, 17 Aug 2018 18:15:39 -0400 2018-08-17T15:00:00-04:00 2018-08-17T16:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: "Towards Automated Epigenetics: Sample Processing with Droplet Microfluidics" (August 20, 2018 9:00am) https://events.umich.edu/event/53781 53781-13461538@events.umich.edu Event Begins: Monday, August 20, 2018 9:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Yi Xu (Advisor: Prof. Ryan C. Bailey)

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Other Mon, 20 Aug 2018 18:15:44 -0400 2018-08-20T09:00:00-04:00 2018-08-20T10:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (August 20, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656653@events.umich.edu Event Begins: Monday, August 20, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-08-20T14:00:00-04:00 2018-08-20T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (August 21, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656564@events.umich.edu Event Begins: Tuesday, August 21, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-08-21T14:00:00-04:00 2018-08-21T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (August 22, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656608@events.umich.edu Event Begins: Wednesday, August 22, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-08-22T14:00:00-04:00 2018-08-22T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (August 27, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656654@events.umich.edu Event Begins: Monday, August 27, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-08-27T14:00:00-04:00 2018-08-27T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (August 28, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656565@events.umich.edu Event Begins: Tuesday, August 28, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-08-28T14:00:00-04:00 2018-08-28T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (August 29, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656609@events.umich.edu Event Begins: Wednesday, August 29, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-08-29T14:00:00-04:00 2018-08-29T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Innovation by Evolution: Expanding the Enzyme Universe (August 30, 2018 4:00pm) https://events.umich.edu/event/51514 51514-12129616@events.umich.edu Event Begins: Thursday, August 30, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


Not satisfied with nature’s vast enzyme repertoire, we want to create new ones and expand the space of genetically encoded enzyme functions. I will describe how we use the most powerful biological design process, evolution, to optimize existing enzymes and invent new ones. In this first lecture, I will describe different evolutionary strategies that allow us to circumvent our profound ignorance of how sequence encodes function. Mimicking nature’s evolutionary tricks and using a little chemical intuition, we can generate whole new enzyme families that catalyze important reactions, including ones not known in nature, thereby adding new capabilities to the chemistry of the biological world and increasing the scope of molecules and materials we can build.














Frances Arnold (California Institute of Technology)

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Other Thu, 30 Aug 2018 18:15:41 -0400 2018-08-30T16:00:00-04:00 2018-08-30T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Bringing new chemistry to life with laboratory-evolved carbene and nitrene transferases (August 31, 2018 2:00pm) https://events.umich.edu/event/51515 51515-12129617@events.umich.edu Event Begins: Friday, August 31, 2018 2:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry
















Frances Arnold (California Institute of Technology)

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Other Fri, 31 Aug 2018 18:15:40 -0400 2018-08-31T14:00:00-04:00 2018-08-31T15:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (September 3, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656655@events.umich.edu Event Begins: Monday, September 3, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-09-03T14:00:00-04:00 2018-09-03T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (September 4, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656566@events.umich.edu Event Begins: Tuesday, September 4, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-09-04T14:00:00-04:00 2018-09-04T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Saltiel Life Sciences Symposium (September 5, 2018 8:45am) https://events.umich.edu/event/51048 51048-11950553@events.umich.edu Event Begins: Wednesday, September 5, 2018 8:45am
Location: Palmer Commons
Organized By: Life Sciences Institute (LSI)

Schedule:

8:45 a.m. | Welcome by U-M Provost and Executive Vice President for Academic Affairs Martin Philbert and LSI Director Roger Cone

8:55 a.m. | Introduction of the Mary Sue and Kenneth Coleman Life Sciences Lecturer
Alan R. Saltiel, Ph.D.
Director, Institute for Diabetes and Metabolic Health, and Professor, University of California, San Diego School of Medicine; Director, Life Sciences Institute 2002-2015

9:00 a.m. | Mary Sue and Kenneth Coleman Life Sciences Lecture — Single cell genomics: When stochasticity meets precision
Xiaoliang Sunney Xie, Ph.D.
Lee Shau-kee Chair Professor, Director of the Biodynamic Optical Imaging Center and Director of the Beijing Advanced Innovation Center for Genomics, Peking University

9:50 a.m. | Morning break

10:10 a.m. | Solving biomedical challenges through single cell genomics approaches
Alexandra-Chloé Villani, Ph.D.
Principal Investigator and Director, Single Cell Genomics Research Program, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital; Member of the Faculty of Medicine, Harvard Medical School; Assistant Scientist, Broad Institute of MIT and Harvard

11:00 a.m. | Exploring the biological basis of neuronal identity and diversity: From transcription mechanism to circuit function
Z. Josh Huang, Ph.D.
Charles and Marie Robertson Professor of Neuroscience, Cold Spring Harbor Laboratory

11:50 a.m. | Poster session and lunch

1:20 p.m. | Spatial genomics and single cell lineage dynamics by seqFISH and MEMOIR
Long Cai, Ph.D.
Professor of Biology and Biological Engineering, Division of Biology and Biological Engineering, California Institute of Technology

2:10 p.m. | Analytics of single cell RNA-SEQ: Lessons from heterogeneity of immune cells
Nir Yosef, Ph.D.
Assistant Professor, Department of Electrical Engineering & Computer Science, University of California, Berkeley

3:00 p.m. | Afternoon break

3:20 p.m. |Myeloid cell contribution to tumor outcome
Miriam Merad, M.D., Ph.D.
Professor and Director of the Precision Immunology Institute, Department of Oncological Sciences and Medicine, Icahn School of Medicine at Mount Sinai

4:10 p.m. | Closing remarks

Thank you to this year's external sponsors: 10x Genomics, Illumina and RareCyte

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Conference / Symposium Wed, 29 Aug 2018 07:19:05 -0400 2018-09-05T08:45:00-04:00 2018-09-05T16:15:00-04:00 Palmer Commons Life Sciences Institute (LSI) Conference / Symposium 2018 Saltiel Life Sciences Symposium
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (September 5, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656610@events.umich.edu Event Begins: Wednesday, September 5, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-09-05T14:00:00-04:00 2018-09-05T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
"Adding, removing and measuring cysteine post-translational modifications" (September 5, 2018 4:00pm) https://events.umich.edu/event/54414 54414-13583288@events.umich.edu Event Begins: Wednesday, September 5, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Brent Martin (University of Michigan)

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Other Wed, 05 Sep 2018 18:15:48 -0400 2018-09-05T16:00:00-04:00 2018-09-05T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Growth and Grit - Developing a Mindset For Success (September 5, 2018 6:00pm) https://events.umich.edu/event/53945 53945-13504379@events.umich.edu Event Begins: Wednesday, September 5, 2018 6:00pm
Location: Undergraduate Science Building
Organized By: Science Learning Center

What if your ability to succeed in your classes was determined in part before you even stepped into the classroom? What is the one quality you need to overcome adversity academically and in life? This workshop will detail the research of Dr. Carol Dweck and her groundbreaking work on the concept of mindset. Students will learn how to abandon a debilitating fixed mindset in favor of a growth mindset, leading to success in areas they once considered too difficult. The workshop will also introduce students to the research of Dr. Angela Duckworth, and how a growth mindset can lead to the development of grit, an essential characteristic to overcoming our fear of failure.

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Workshop / Seminar Mon, 20 Aug 2018 12:48:39 -0400 2018-09-05T18:00:00-04:00 2018-09-05T19:00:00-04:00 Undergraduate Science Building Science Learning Center Workshop / Seminar
BMS Symposium (September 6, 2018 4:00pm) https://events.umich.edu/event/53782 53782-13461539@events.umich.edu Event Begins: Thursday, September 6, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Society depends on polymeric materials more now than at any other time in history. Although synthetic polymers are indispensable in a diverse array of applications, ranging from commodity packaging and structural materials to technologically complex biomedical and electronic devices, their synthesis and disposal pose important environmental challenges. The focus of our research is the development of sustainable routes to polymers that have reduced environmental impact. This lecture will focus on our research to transition from fossil fuels to renewable resources for polymer synthesis, as well as the development of polymeric materials designed to bring positive benefits to the environment.












Adrian Ortiz(Bristol Myers Squibb) , Geoffrey Coates(Cornell University)

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Other Thu, 06 Sep 2018 18:15:58 -0400 2018-09-06T16:00:00-04:00 2018-09-06T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
"Bimolecular Concert at the Cell Membrane Interface" (September 7, 2018 4:00pm) https://events.umich.edu/event/53436 53436-13381405@events.umich.edu Event Begins: Friday, September 7, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Physicochemical and structural properties of molecules at the cell membrane interface are crucial for cellular and other biological functions, and are implicated in numerous diseases including amyloid diseases and bacterial/viral infection. While it is obvious that such properties must be fully characterized for biotechnological and biomedical purposes, the intrinsic complexity of the lipid bilayer environment poses tremendous challenges to most biophysical techniques and biochemical approaches. The Ramamoorthy group has been developing novel membrane mimetics and biophysical (including NMR) approaches to overcome these challenges, and apply them to investigate dynamic structures of membrane proteins and membrane-assisted amyloid aggregation processes. The Biophysical Concert will focus on the following specific topics to highlight the challenges and recent advances:

*Advantages and limitations of "sushi-like" lipid-nanodiscs (Ravula)
*Probing atomic-resolution "hugs and kisses" that enable enzymatic function (Gentry)
*Capturing the amyloid-ghosts red-handed by nanodiscs (Sahoo)
*Atomic-resolution "weed-and-feed" action of amyloid-inhibitors (Cox)

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Workshop / Seminar Thu, 30 Aug 2018 15:05:49 -0400 2018-09-07T16:00:00-04:00 2018-09-07T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (September 10, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656656@events.umich.edu Event Begins: Monday, September 10, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-09-10T14:00:00-04:00 2018-09-10T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
"Catalytic Carbonyl-Olefin Metathesis and Oxygen Atom Transfer" (September 10, 2018 4:00pm) https://events.umich.edu/event/54415 54415-13583289@events.umich.edu Event Begins: Monday, September 10, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Corinna Schindler (University of Michigan)

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Other Mon, 10 Sep 2018 18:15:46 -0400 2018-09-10T16:00:00-04:00 2018-09-10T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (September 11, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656567@events.umich.edu Event Begins: Tuesday, September 11, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-09-11T14:00:00-04:00 2018-09-11T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (September 12, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656611@events.umich.edu Event Begins: Wednesday, September 12, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-09-12T14:00:00-04:00 2018-09-12T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Make It Stick - Research-based Learning Strategies You Need to Know (September 12, 2018 6:00pm) https://events.umich.edu/event/53949 53949-13504381@events.umich.edu Event Begins: Wednesday, September 12, 2018 6:00pm
Location: Undergraduate Science Building
Organized By: Science Learning Center

The study and learning strategies students often bring to college are often insufficient to help them succeed at the university level. Particularly in challenging STEM courses, students can't simply memorize or cram their way to a good grade. This workshop will focus on the popular learning strategies to avoid, as well as the top three strategies you don't know but are shown by research to be the most effective for long-term learning.

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Workshop / Seminar Mon, 20 Aug 2018 12:54:53 -0400 2018-09-12T18:00:00-04:00 2018-09-12T19:00:00-04:00 Undergraduate Science Building Science Learning Center Workshop / Seminar
Natural product bioactive peptide discovery via PepSAVI-MS (September 13, 2018 4:00pm) https://events.umich.edu/event/53888 53888-13472315@events.umich.edu Event Begins: Thursday, September 13, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

As current methods for antibiotic drug discovery are being outpaced by the rise of antimicrobial resistance, new methods and innovative technologies are crucial to replenish our dwindling arsenal of antimicrobial therapeutics. While natural products are a well-studied source of biologically active small molecules, peptidyl factors contributing to their medicinal properties remain largely unexplored. To this end, we have developed the PepSAVI-MS (Statistically-guided bioactive peptides prioritized via mass spectrometry) pipeline1 to identify bioactive peptide targets from complex biological samples. MS/MS techniques such as CID, ETD, UVPD are implemented for de novo characterization. To validate this pipeline, we have demonstrated successful detection and identification of a known antimicrobial peptide, cycloviolacin O2 (cyO2), from the botanical species Viola odorata. Additionally, we have widened the known antimicrobial spectrum for V. odorata cyclotides, including antibacterial activity of cyO2 against A. baumannii and novel anticancer activities for cycloviolacins by their cytotoxicity against ovarian, breast and prostate cancer cell lines. The developed platform is highly versatile as it is adaptable to any natural product source of peptides and can test against diverse physiological targets, including bacteria, fungi, viruses, protozoans, and cancer cells for which there is a developed bioassay. As such, we demonstrate extension of this pipeline to fungal and bacterially-sourced AMPs through the identification of the killer toxin KP4 from Ustilago maydis2 and the bacteriocin Bac-21 from Enterococcus faecalis harboring pPD1. Bac-21 is identical in nucleotide sequence to another enterococcal bacteriocin, AS-48, but we have experimentally validated the protein sequence of Bac-21 for the first time. Additionally, we begin to probe the vast array of botanical natural product sources to prioritize highly active species for downstream analysis.
















Leslie Hicks (The University of North Carolina at Chapel Hill)

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Other Wed, 12 Sep 2018 12:15:52 -0400 2018-09-13T16:00:00-04:00 2018-09-13T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Taubman Technology Talks (September 13, 2018 5:00pm) https://events.umich.edu/event/54149 54149-13530692@events.umich.edu Event Begins: Thursday, September 13, 2018 5:00pm
Location: Frankel Cardiovascular Center
Organized By: A. Alfred Taubman Medical Research Institute

Fei Wen, PhD, Dow Corning Assistant Professor, Department of Chemical Engineering will present, ““A 40-parameter view of the immune landscape at single-cell resolution…and other cool things you can do with CyTOF!” in the inaugural Taubman Technology Talk.

Her presentation will be 5-5:45 pm followed by a 15-min.question and answer period. A reception will follow from 6-7 pm.

The Taubman Technology Talks is a new series sponsored by the Taubman Institute, that aims to inform the UM community about the ongoing advances in technologies. All welcome; please join us!

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Lecture / Discussion Thu, 23 Aug 2018 15:51:51 -0400 2018-09-13T17:00:00-04:00 2018-09-13T19:00:00-04:00 Frankel Cardiovascular Center A. Alfred Taubman Medical Research Institute Lecture / Discussion TechTalk Sept 13 flyer
Seminar Title: "Magnetic Resonance Studies of Membrane Proteins" (September 14, 2018 4:00pm) https://events.umich.edu/event/53437 53437-13381406@events.umich.edu Event Begins: Friday, September 14, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: CW and pulsed Electron Paramagnetic Resonance (EPR) spectroscopic techniques coupled with site-directed spin-labeling (SDSL) can provide important structural information on complicated biological systems such as membrane proteins. Strategically placed spin-labels alter relaxation times of NMR active nuclei and yield pertinent structural information. EPR techniques such as Double Electron-Electron Resonance (DEER) and Electron Spin Echo Envelope Modulation (ESEEM) are powerful structural biology tools. The DEER technique can be used to measure distances between 2 spin labels from 20 to 70 Å. However, the application of DEER spectroscopy to study membrane proteins can be difficult due to short phase memory times (Tm) and weak DEER modulation in more biologically relevant proteoliposomes when compared to water soluble proteins or membrane proteins in detergent micelles. The combination of these factors often leads to broad distance distributions, poor signal to noise, and limitations in the determination of longer distances. The short phase memory times are typically due to uneven distributions of spin-labeled protein within the lipid bilayer, which creates local inhomogeneous pockets of high spin concentrations. Approaches to overcome these limitations and improve the quality of DEER measurements for membrane proteins will be discussed: lipodisq nanoparticles, bi-functional spin labels (BSL), and Q-band pulsed EPR spectroscopy. ESEEM data will be shown to probe the secondary structure of membrane proteins. CW-EPR spectra of spin-labeled membrane proteins will be used to investigate dynamics and the immersion depth in a lipid bilayer.

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Workshop / Seminar Thu, 30 Aug 2018 16:29:54 -0400 2018-09-14T16:00:00-04:00 2018-09-14T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Gary Lorigan
General Mills Info Session (September 16, 2018 3:30pm) https://events.umich.edu/event/55246 55246-13707119@events.umich.edu Event Begins: Sunday, September 16, 2018 3:30pm
Location: Herbert H. Dow Building
Organized By: The Society of Asian Scientists and Engineers at the University of Michigan-Ann Arbor

General Mills is coming to discuss their opportunities for our students so make sure to come on out!

Make sure to join our FB group for more networking events SASE UM 2018-2019 and our mailing list @ www.tinyurl.com/sase-umich/ . To see our calendar of events, check out our new website @ www.umich.edu/~sase/ !

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Careers / Jobs Fri, 14 Sep 2018 10:59:03 -0400 2018-09-16T15:30:00-04:00 2018-09-16T17:00:00-04:00 Herbert H. Dow Building The Society of Asian Scientists and Engineers at the University of Michigan-Ann Arbor Careers / Jobs Flyer
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (September 17, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656657@events.umich.edu Event Begins: Monday, September 17, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-09-17T14:00:00-04:00 2018-09-17T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (September 18, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656568@events.umich.edu Event Begins: Tuesday, September 18, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-09-18T14:00:00-04:00 2018-09-18T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (September 19, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656612@events.umich.edu Event Begins: Wednesday, September 19, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-09-19T14:00:00-04:00 2018-09-19T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Ultrafast tabletop XUV spectroscopy of transition metal complexes and organohalide perovskites (September 20, 2018 4:00pm) https://events.umich.edu/event/52759 52759-13021395@events.umich.edu Event Begins: Thursday, September 20, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

X-ray absorption near edge spectroscopy (XANES or NEXAFS) is a powerful technique for electronic structure determination. However, widespread use of XANES is limited by the need for synchrotron light sources with tunable x-ray energy. Recent developments in extreme ultraviolet (XUV) light sources using the laser-based technique of high-harmonic generation have enabled core-level spectroscopy to be performed on femtosecond to attosecond timescales. We have extended the scope of tabletop XUV spectroscopy and demonstrated that M2,3-edge XANES, corresponding to 3p→3d transitions, can reliably measure the electronic structure of first-row transition metal coordination complexes with femtosecond time resolution. We use this ability to track the excited-state relaxation pathways of photocatalysts and spin crossover complexes. In semiconductors such as CH3NH3PbI3, distinct signals are observed for photoinduced electrons and holes, allowing the dynamics of each carrier to be tracked independently. This work establishes high-harmonic spectroscopy as a useful tool for mainstream research in inorganic, organometallic, and materials chemistry.
















Josh Vura-Weis (University of Illinois)

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Other Thu, 20 Sep 2018 12:15:46 -0400 2018-09-20T16:00:00-04:00 2018-09-20T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Nanoparticles Meet Biological Membranes: Probing Interaction Using Molecular Simulations (September 21, 2018 4:00pm) https://events.umich.edu/event/53428 53428-13381397@events.umich.edu Event Begins: Friday, September 21, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract:
Over the past decade, with advances in high-performance computing and data science, theory,
simulation, and computation continue to partner with experiment in discovery and innovation in
nanoscience and nanotechnology. Some of the most exciting applications are in the field of biomedicine. Indeed, a detailed understanding of the molecular details of interactions between nanoparticles and biological nanosystems, such as membranes or macromolecules is crucial for obtaining adequate information on mechanisms of action of nanomaterials as well as a perspective on the long-term effects of these materials and their possible toxicological outcomes. In this talk I will report on a new model that we are developing to understand and to predict the interactions between carbon-based nanomaterials and biological membranes using structure-based computational molecular modeling. A rationale on how nanoparticles of different sizes, shape, structure and chemical properties can affect the organization of cellular membranes is also presented. This critical information will help enable the “safe-by-design” production of engineered nanoparticles that are nontoxic or biocompatible, and also allow for the design of antimicrobial nanoparticles for environmental and biomedical applications.

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Workshop / Seminar Fri, 21 Sep 2018 10:31:41 -0400 2018-09-21T16:00:00-04:00 2018-09-21T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (September 24, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656658@events.umich.edu Event Begins: Monday, September 24, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-09-24T14:00:00-04:00 2018-09-24T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
RNA as a Drug Target and Material for Nanotechnology (September 24, 2018 4:00pm) https://events.umich.edu/event/51011 51011-11941993@events.umich.edu Event Begins: Monday, September 24, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Research in the Hermann lab is focused on exploring the structure, molecular recognition and assembly of ribonucleic acid (RNA) architectures.
One key goal is the development of therapies targeting noncoding RNA (ncRNA). ncRNAs participate as key players in many biological processes and may adopt complex folds that are required for function. The development of ligands that bind selectively to ncRNA targets opens new ways to expand the existing repertoire of protein-directed therapeutics. I will present our research on the discovery of an unprecedented molecular switch target in the genome of RNA viruses including the human pathogen hepatitis C virus (HCV) and the development of ligands that inhibit the viral switch.
In the second part of the presentation, I will outline how we use RNA crystal structures to design nano-architectures that self-assemble from small RNA motifs and may serve as combinatorial platforms for applications in molecular recognition, sensor and catalyst development as well as protein interaction studies.












Thomas Hermann (University of California, San Diego)

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Other Mon, 24 Sep 2018 18:15:45 -0400 2018-09-24T16:00:00-04:00 2018-09-24T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (September 25, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656569@events.umich.edu Event Begins: Tuesday, September 25, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-09-25T14:00:00-04:00 2018-09-25T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Bioethics Discussion: Drugs (September 25, 2018 7:00pm) https://events.umich.edu/event/49421 49421-11453763@events.umich.edu Event Begins: Tuesday, September 25, 2018 7:00pm
Location: Lurie Biomedical Engineering
Organized By: The Bioethics Discussion Group

A roundtable discussion on the manipulation of our biochemical status.

Readings to consider:
"Towards responsible use of cognitive-enhancing drugs by the healthy"
"Adverse health effects of marijuana use"
"Practical, legal, and ethical issues in expanded access to investigational drugs"

For more information and/or to receive a copy of the readings, please contact Barry Belmont at belmont@umich.edu or visit https://belmont.bme.umich.edu/bioethics-discussion-group/discussions/017-drugs/.

Partake in the blog: https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Thu, 13 Sep 2018 17:53:37 -0400 2018-09-25T19:00:00-04:00 2018-09-25T20:30:00-04:00 Lurie Biomedical Engineering The Bioethics Discussion Group Lecture / Discussion Drugs
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (September 26, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656613@events.umich.edu Event Begins: Wednesday, September 26, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-09-26T14:00:00-04:00 2018-09-26T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Multi-scale chemistry: From molecular to microsystems (September 27, 2018 4:00pm) https://events.umich.edu/event/53783 53783-13461540@events.umich.edu Event Begins: Thursday, September 27, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The design and manipulation of molecules and chemical reactions offers the possibility for the engineering of materials and devices at multiple length scales from the molecular to the nano, micro, and macro. By way of several examples, this seminar will highlight how chemistry can be used across length scales to create programmable materials, 3D biosensors, and physiologically responsive robots.























David Gracias (Johns Hopkins University)

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Other Thu, 27 Sep 2018 18:15:50 -0400 2018-09-27T16:00:00-04:00 2018-09-27T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
The Ross Effect (September 27, 2018 4:00pm) https://events.umich.edu/event/55018 55018-13665226@events.umich.edu Event Begins: Thursday, September 27, 2018 4:00pm
Location: Ross School of Business
Organized By: Ross One Year Graduate Programs

Employers look for the skills you’re developing in your undergraduate degree, like the ability to understand complex concepts and deliver creative solutions. But, connecting with companies and highlighting these skills is not always easy. Join us at "The Ross Effect" to learn how three outstanding Ross graduate programs, the Master of Accounting, the Master of Management and the Master of Supply Chain Management, will leverage your undergraduate training for a smooth and successful transition into the workforce.

This event is being held exclusively for non-Ross University of Michigan (Ann Arbor) students. The event is being held on the 5th floor of the Blau/Kresge side of the Ross Building, in the Blau Colloquium.

Questions? Email TheRossEffect@umich.edu

Register at:
https://www.eventbrite.com/e/the-ross-effect-how-a-ross-graduate-degree-amplifies-your-toolkit-registration-48421327494

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Presentation Fri, 07 Sep 2018 18:53:32 -0400 2018-09-27T16:00:00-04:00 2018-09-27T17:30:00-04:00 Ross School of Business Ross One Year Graduate Programs Presentation Michigan Ross Logo
Folded Viral RNAs that Sense and Manipulate the Host Cell Machinery: Windows to RNA Structure-Based Regulation (September 28, 2018 4:00pm) https://events.umich.edu/event/53429 53429-13381398@events.umich.edu Event Begins: Friday, September 28, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: RNA is perhaps the most functionally diverse biological macromolecule, due in large part to its ability to adopt a wide range of conformationally dynamic structures. The Kieft Lab is interested in understanding how RNA can adopt diverse three-dimensional folds, how those folds give rise to its many biological roles, and how conformational changes confer RNA’s ability to regulate so many processes. We are particularly interested in viral RNAs, which are fine-tuned by evolution to elegantly and powerfully interact with and manipulate the cellular machinery of the host cell; these viral RNAs provide a “window” into the greater RNA world. In this presentation, I will present some of our recent findings in regard to a viral RNA that adopts an unexpected tertiary structure. This RNA element undergoes programmed conformational changes that are triggered by its interactions with the host cell machinery and this is responsible for its unique function. This RNA may be a paradigm for novel modes of regulation linked to dynamic RNA conformational changes.

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Workshop / Seminar Wed, 26 Sep 2018 14:41:29 -0400 2018-09-28T16:00:00-04:00 2018-09-28T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Jeffrey Kieft
Green Wolverine Science Symposium (September 29, 2018 10:00am) https://events.umich.edu/event/54954 54954-13656393@events.umich.edu Event Begins: Saturday, September 29, 2018 10:00am
Location: Ross School of Business
Organized By: Green Wolverine

Through collaboration with the University of Michigan College of Pharmacy and School of Nursing, Green Wolverine is hosting speakers from across the country for a CANNABIS SCIENCE SYMPOSIUM This is the first student-organized science symposium of its kind at the university.

Green Wolverine was founded with the goal of promoting education and public awareness of the importance of evidence-based discourse, in terms of deciding the future of cannabis in medicine, research, and industry.

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Conference / Symposium Thu, 06 Sep 2018 20:38:22 -0400 2018-09-29T10:00:00-04:00 2018-09-29T16:20:00-04:00 Ross School of Business Green Wolverine Conference / Symposium World-class researchers, scientists, and physicians gather in Ann Arbor to illuminate the future of cannabis medicine, research, and industry.
Donuts & Cider in the Duderstadt Connector (October 1, 2018 11:00am) https://events.umich.edu/event/56050 56050-13823410@events.umich.edu Event Begins: Monday, October 1, 2018 11:00am
Location: Chrysler Center
Organized By: Multidisciplinary Design Program

Stop by the Duderstadt Connector for Apple Cider & Washtenaw Dairy Donuts between 10 am and 2pm on Monday, October 1st.

Pick up a 2019 MDP Program Booklet, get tips for how to apply, and prepare for one of the major MDP recruitment events on 10/2 or 10/3.

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Exhibition Wed, 26 Sep 2018 13:10:22 -0400 2018-10-01T11:00:00-04:00 2018-10-01T14:00:00-04:00 Chrysler Center Multidisciplinary Design Program Exhibition Cider and Donuts
2018 Organic Reactions Symposium (October 1, 2018 1:00pm) https://events.umich.edu/event/50748 50748-11861929@events.umich.edu Event Begins: Monday, October 1, 2018 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

We recently explored the possibility of using gold(I) catalysts to activate allenes towards alcohol nucleophiles to effect allenoate Claisen rearrangements. However, instead of allene activation, a pendant ester was transesterified and etherified, which led to our development of a gold-catalyzed, microwave protocol to activate alcohols to form ethers and amines via an intermolecular, SN1-type reaction. Ultimately, in lieu of a metal-catalyzed version, we have developed a Bronsted acid-catalyzed allenoate Claisen that affords the corresponding products in high yields and enantioselectivities. Lessons learned from these studies have led to the serendipitous discovery of a silver-catalyzed, N-formylation reaction and have informed our development of an anti-Markovnikov hydroamination reaction.








Scott Denmark(University of Illinois) , Noah Burns(Stanford University) , Anna Wenzel(Claremont McKenna College)

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Other Mon, 01 Oct 2018 18:15:51 -0400 2018-10-01T13:00:00-04:00 2018-10-01T18:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (October 1, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656659@events.umich.edu Event Begins: Monday, October 1, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-10-01T14:00:00-04:00 2018-10-01T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
RNA Innovation Seminar | Theme: Computational analysis (October 1, 2018 3:00pm) https://events.umich.edu/event/55316 55316-13716052@events.umich.edu Event Begins: Monday, October 1, 2018 3:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Li Guan, PhD candidate
from the Laura Scott research group
“Human skeletal muscle eQTL meta-analysis reveals long-range genetic regulations”
&
Shiquan Sun, Ph.D.,
Postdoctoral fellow from the Zhou Lab
“Heritability estimation and differential analysis of count data with generalized linear mixed models in genomic sequencing studies”

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Lecture / Discussion Tue, 25 Sep 2018 08:52:23 -0400 2018-10-01T15:00:00-04:00 2018-10-01T16:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion seminar flyer
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (October 2, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656570@events.umich.edu Event Begins: Tuesday, October 2, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-10-02T14:00:00-04:00 2018-10-02T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Insights into Complex Molecular Processes from Quantitative Atomistic Simulations (October 2, 2018 4:00pm) https://events.umich.edu/event/52807 52807-13081672@events.umich.edu Event Begins: Tuesday, October 2, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Molecular dynamics simulations are a powerful means to provide
molecular-level insights into processes ranging from gas-phase
reaction dynamics to complex non-reactive and reactive rearrangements
in biological systems. The utility of such simulations depends
sensitively on the accuracy with which the intermolecular interactions
are represented. In this seminar I will discuss recent progress in
force field development including multipolar force fields, reproducing
kernel Hilbert space techniques and machine learning and their
application to spectroscopy and reactive processes in the condensed
phase. The focus is on directly linking experimental observations with
computations which provides molecular level understanding of
spectroscopic observables and time scales from state-of-the art
experiments. A typical example discussed will be the relationship
between structure and dynamics for infrared and X-ray absorption
spectroscopy of biomolecules or the thermodynamics of reversed phase
liquid chromatography.
















Markus Meuwly (University of Basel, Switzerland)

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Other Tue, 02 Oct 2018 18:15:46 -0400 2018-10-02T16:00:00-04:00 2018-10-02T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
MDP 2019 Project Preview Night (October 2, 2018 6:00pm) https://events.umich.edu/event/56264 56264-13869403@events.umich.edu Event Begins: Tuesday, October 2, 2018 6:00pm
Location: BBB
Organized By: Multidisciplinary Design Program

Student Recruitment for 2019 MDP Teams Has Begun!

You will shake hands and speak with Faculty PIs and engineering and product development professionals about the MDP team they are sponsoring. Build your network, learn about the teams, and position yourself as a great candidate. Attire is casual!

What is the MDP Project Preview Night?

The 2019 MDP Project Preview Night will showcase 40+ teams with open positions for students across the University. All Corporate Partners and Faculty Research Teams will be in the BBB Building to meet with interested students, discuss design team opportunities, and collect student resumes. Attend this event if you cannot attend the Project Fair on Wednesday. Casual attire is expected.

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Careers / Jobs Mon, 01 Oct 2018 14:48:25 -0400 2018-10-02T18:00:00-04:00 2018-10-02T20:00:00-04:00 BBB Multidisciplinary Design Program Careers / Jobs BBB Atrium
Medicinal Chemistry & Pharmaceutical Sciences Open House (October 2, 2018 6:00pm) https://events.umich.edu/event/55689 55689-13768291@events.umich.edu Event Begins: Tuesday, October 2, 2018 6:00pm
Location: Palmer Commons
Organized By: U-M College of Pharmacy

Attention all Science, Pre-Health, and Engineering majors!

Are you interested in learning about graduate programs that will prepare you for an exciting career in drug discovery & drug development? If so, please make plans to attend the Medicinal Chemistry & Pharmaceutical Sciences Open House.

This event will feature a poster session where you can talk to graduate students and faculty members about their research. You will also have an opportunity to learn more about the benefits and requirements of the Medicinal Chemistry & Pharmaceutical Sciences PhD programs.

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Other Wed, 19 Sep 2018 16:03:49 -0400 2018-10-02T18:00:00-04:00 2018-10-02T20:30:00-04:00 Palmer Commons U-M College of Pharmacy Other
CGIS Study Abroad Fair (October 3, 2018 12:00pm) https://events.umich.edu/event/44037 44037-9877694@events.umich.edu Event Begins: Wednesday, October 3, 2018 12:00pm
Location: Michigan League
Organized By: Center for Global and Intercultural Study

Advisors, CGIS Alumni, and program representatives from around campus and the world will answer your questions about UM study abroad opportunities. Learn about UM faculty-led programs and meet with staff from the Office of Financial Aid and the LSA Scholarship Office. Enjoy performances from global student orgs, maize-n-blue giveaways, and free candy from around the world!

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Fair / Festival Sun, 02 Sep 2018 11:01:54 -0400 2018-10-03T12:00:00-04:00 2018-10-03T16:00:00-04:00 Michigan League Center for Global and Intercultural Study Fair / Festival Study Abroad!
MDP 2019 Project Fair (October 3, 2018 12:00pm) https://events.umich.edu/event/56265 56265-13869404@events.umich.edu Event Begins: Wednesday, October 3, 2018 12:00pm
Location: Duderstadt Center
Organized By: Multidisciplinary Design Program

Student Recruitment for 2019 MDP Teams Has Begun!

You will shake hands and speak with Faculty PIs and engineering and product development professionals about the MDP team they are sponsoring. Build your network, learn about the teams, and position yourself as a great candidate. Attire is casual!

What is the MDP Project Fair?

The 2019 MDP Project Opportunity Fair will showcase 40+ teams with open positions for students across the University. All Corporate Partners and Faculty Research Teams will be in the Duderstadt Atrium to meet with interested students, discuss design team opportunities, and collect student resumes. Attend this event if you cannot attend the Project Preview Night on Tuesday. Casual attire is expected.

This event is very, very similar to the Project Preview night on 10/2 6-8pm in BBB….just in a different location, and the sponsors/faculty will have table displays with prototypes, screens, giveaways, etc. Attend either event – whichever fits your busy schedule.

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Careers / Jobs Mon, 01 Oct 2018 15:14:43 -0400 2018-10-03T12:00:00-04:00 2018-10-03T16:00:00-04:00 Duderstadt Center Multidisciplinary Design Program Careers / Jobs Duderstadt Connector
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (October 3, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656614@events.umich.edu Event Begins: Wednesday, October 3, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-10-03T14:00:00-04:00 2018-10-03T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Exploring Indoor Chemistry: Criegees, Chlorohydrins, and Nitrous Acid (October 4, 2018 4:00pm) https://events.umich.edu/event/52146 52146-12477549@events.umich.edu Event Begins: Thursday, October 4, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The chemical interactions that proceed indoors have not been as well studied as those that occur in outdoor environments. Rather, indoors, focus has primarily been given to emissions from building materials and effects of ventilation. However, it is known that oxidative and partitioning processes occur on most indoor surfaces that affect the chemical exposure that we all experience. Indeed, the concentrations of many chemical species are higher indoors than outdoors. This talk will present examples of indoor oxidative processes that arise via ozone, which is introduced by intake of outdoor air, and via cleaning agents, such as chlorine bleach. Highly reactive surfaces indoors include human skin oils and cooking emissions, and particular attention will be given to the ozonolysis products formed from Criegee intermediates. The nature of non-reactive partitioning in indoor species will also be examined. In particular, new field measurements indicate that molecules that are normally viewed as being highly reactive, such as nitrous acid, are sorbed to indoor surfaces in significant amounts.








Jonathan Abbatt (University of Toronto)

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Other Thu, 04 Oct 2018 18:15:51 -0400 2018-10-04T16:00:00-04:00 2018-10-04T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Analytical 3rd Year Student Seminars (October 5, 2018 4:00pm) https://events.umich.edu/event/54982 54982-13662978@events.umich.edu Event Begins: Friday, October 5, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Megan Connor(Shultz Lab) , Matt Sorensen(Kennedy Lab)

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Other Fri, 05 Oct 2018 18:15:49 -0400 2018-10-05T16:00:00-04:00 2018-10-05T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: "Functional approaches to understanding the development of the Small Multidrug Resistance family of transporters"- Chris Macdonald and "The effect of disruption of synaptic signaling on brain networks" - Maral Budak (October 5, 2018 4:00pm) https://events.umich.edu/event/53431 53431-13381399@events.umich.edu Event Begins: Friday, October 5, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract:
Chris Macdonald - The Small Multidrug Resistance (SMR) family of prokaryotic and archaean proton-coupled transporters provides a window into the evolutionary events that generated the molecular diversity of membrane protein function today. These small 4-pass integral membrane proteins assemble into functional dimers with an unusual antiparallel architecture. The most well-studied example, EmrE, is a homodimeric member that provides resistance to a broad range of hydrophobic cationic aromatic compounds. This talk will cover recent work in the Stockbridge lab that has fundamentally altered our understanding of this family, including functional characterization through flux measurements and solid-supported membrane (SSM) electrophysiology, in vivo metabolic assays, and phylogenetic analysis. We suggest an evolutionary trajectory for the development of new functions in these small proteins.

and

Maral Budak -The information transmission between neurons and brain regions occurs via synapses. Therefore, disruption of synaptic signaling (e.g. synaptic failure or desynchronization of spikes) may have devastating outcomes, such as loss of consciousness or neurodegenerative diseases. First, our objective is understanding the effect of synaptic failure on functional connectivity of different network structures, and we observed that synaptic failure does not always decrease the coherence of neuronal networks, but sometimes promotes the formation of coherent states of activity in the networks. Next, we aim to understand the mechanism of hidden hearing loss caused by myelinopathy. Recently, it’s been hypothesized that disruption of myelination patterns at auditory nerves (AN) causes desynchronization of AN spiking activity. To test this hypothesis, we constructed a reduced biophysical model for a population of inner hair cells with postsynaptic auditory nerve fibers. As a result, our model confirms that heminodal disruption causes desynchronization of AN spikes leading to a loss of temporal resolution.

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Workshop / Seminar Mon, 01 Oct 2018 11:59:37 -0400 2018-10-05T16:00:00-04:00 2018-10-05T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (October 8, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656660@events.umich.edu Event Begins: Monday, October 8, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-10-08T14:00:00-04:00 2018-10-08T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Nitric Oxide Signaling: From Prokaryotes to Humans (October 8, 2018 4:00pm) https://events.umich.edu/event/50775 50775-11864796@events.umich.edu Event Begins: Monday, October 8, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Nitric oxide (NO) has long been known to be an intermediate in bacterial pathways of denitrification. It is only since the middle to late 1980s that it was found to play a central role in a much broader biology context. For example, it is now well established that NO acts as a signaling agent in higher organisms. Yet NO is toxic and reactive under biological conditions. How is the biology carried out by NO controlled? How is NO used and the inherent toxicity avoided? How do organisms tell the difference between NO and O2? What is the biological output? A molecular perspective on ligand discrimination in hemoproteins has emerged as has a further understanding and predictions about selective ligand sensing and function in biology.














Michael Marletta (University of Berkeley)

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Other Mon, 08 Oct 2018 18:15:47 -0400 2018-10-08T16:00:00-04:00 2018-10-08T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (October 9, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656571@events.umich.edu Event Begins: Tuesday, October 9, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-10-09T14:00:00-04:00 2018-10-09T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Nandini Ananth: Charge Transfer Dynamics, Excited State Energetics, and Organic Photovoltaics (October 9, 2018 4:00pm) https://events.umich.edu/event/56196 56196-13860237@events.umich.edu Event Begins: Tuesday, October 9, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Michigan Institute for Computational Discovery and Engineering

Designing molecular materials for use as organic photovoltaics, molecular electronics, and photocatalysts is a multifaceted challenge requiring a detailed understanding of both the excited state energetics and the dynamics of charge and energy transfer. We address the dynamic challenge by developing new methods based on the path integral formulation of quantum mechanics that are uniquely suited to the simulation of photo-initiated excited state dynamics in the condensed phase. We then tackle the characterization of the excited state manifold in molecular systems using a combination of high-level electronic structure methods to accurately calculate excited state energies, normal mode analysis to quantify vibronic couplings, and novel orbital analyses to uncover structure-spectrum correlations.
In this talk, we focus on one target application: designing chromophores that exhibit ultrafast Singlet Fission (SF), a phenomenon that has the potential to significantly increase organic solar cell efficiency. We investigate SF in non-bonded and covalently bonded pentacene dimers: we uncover two distinct mechanistic pathways for ultrafast SF and we identify molecular geometries and bonding motifs that can be modified to enhance efficiency in each case. Finally, we combine the insights obtained from our theoretical investigations to generate a priori design principles for next-generation SF chromophores, and working with experimental collaborators, we verify them.

Nandini Ananth is an associate professor in the department of Chemistry and Chemical Biology at Cornell University. She received her bachelor's degree in Chemistry from Stella Maris College in Chennai, India, and a Masters in chemistry from the Indian Institute of Technology Madras.

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Workshop / Seminar Sun, 30 Sep 2018 15:14:35 -0400 2018-10-09T16:00:00-04:00 2018-10-09T17:00:00-04:00 Chemistry Dow Lab Michigan Institute for Computational Discovery and Engineering Workshop / Seminar Ananth
Watching metalloenzymes at work (October 9, 2018 4:00pm) https://events.umich.edu/event/53784 53784-13461541@events.umich.edu Event Begins: Tuesday, October 9, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Structures of bioinorganic catalysts can often uniquely rationalize important aspects of chemical and biological reaction control. My research group studies the structural differences between members of large metalloenzyme superfamilies that share common characteristics but trigger different reactions or use distinct cofactors. We have initially focused on systems unified in their ability to activate strong C-H, N-H, or O-H bonds. Key objectives include identification of the outcome-dictating structural features of a given catalyst and structure-guided reprogramming for new function. To achieve these ends, we determine stable reactant and product complexes, with an increasing focus on development and implementation of crystallographic approaches to study metalloenzyme reaction intermediates. These experiments are challenging due to the fleeting and reactive nature of these states but uniquely informative because of the fully contextualized view they provide at critical points in the catalytic cycle.












Amie Boal (The Pennsylvania State University)

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Other Tue, 09 Oct 2018 18:15:46 -0400 2018-10-09T16:00:00-04:00 2018-10-09T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Chemistry: More than Just a Magic Trick (October 9, 2018 5:30pm) https://events.umich.edu/event/53826 53826-13463715@events.umich.edu Event Begins: Tuesday, October 9, 2018 5:30pm
Location: Off Campus Location
Organized By: Osher Lifelong Learning Institute (50+)

Do you ever wonder about the science behind the making of your favorite libation? Or how about the process that is used to make your favorite fragrance? And what about all the plastic we use in our daily lives? If so, your queries can all be answered through chemistry and this course will focus on the magical chemical processes behind the making of beer and wine, the production of food and artificial flavors and the generation of plastics.

Come join us to learn how to think like chemists as we discuss these topics and any others you might have in mind!

Instructors Ellen Aguilera and Elizabth Meucci are graduate students working towards their Ph.D. in organic chemistry. They share a passion for science and look forward to sharing their “magic tricks” with you! This study group for those 50 and over will meet on Tuesdays, 5:30-7 p.m., from October 9 through November 27

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Class / Instruction Thu, 16 Aug 2018 10:22:11 -0400 2018-10-09T17:30:00-04:00 2018-10-09T19:00:00-04:00 Off Campus Location Osher Lifelong Learning Institute (50+) Class / Instruction OLLI Study Group
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (October 10, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656615@events.umich.edu Event Begins: Wednesday, October 10, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-10-10T14:00:00-04:00 2018-10-10T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Analytical 3rd Year Student Seminars (October 10, 2018 4:00pm) https://events.umich.edu/event/54983 54983-13662979@events.umich.edu Event Begins: Wednesday, October 10, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry








Nicole Olson(Ault Lab) , Daniel Vallejo(Ruotolo Lab)

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Other Wed, 10 Oct 2018 18:15:47 -0400 2018-10-10T16:00:00-04:00 2018-10-10T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Innovate Blue: Engaging in Innovation & Entrepreneurship at U-M (October 10, 2018 5:30pm) https://events.umich.edu/event/53951 53951-13504382@events.umich.edu Event Begins: Wednesday, October 10, 2018 5:30pm
Location: Hatcher Graduate Library
Organized By: Science Learning Center

Innovate Blue is the network of more than 15 different centers and departments at U-M supporting the mission of encouraging innovation, creativity and an entrepreneurial spirit that spurs economic development and contributes to the public good. This workshop will introduce a few of the departments where they will present examples of previous student initiatives launched with the support of U-M, and introduce new opportunities for students to engage to pursue an entrepreneurial mindset. Ideal for ALL majors!

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Workshop / Seminar Mon, 20 Aug 2018 12:58:48 -0400 2018-10-10T17:30:00-04:00 2018-10-10T19:00:00-04:00 Hatcher Graduate Library Science Learning Center Workshop / Seminar Hatcher Graduate Library
Quantum Coherence in Chemistry: Tackling the Decoherence Challenge (October 11, 2018 4:00am) https://events.umich.edu/event/52043 52043-12376521@events.umich.edu Event Begins: Thursday, October 11, 2018 4:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

A subject of considerable current interest in Chemistry is the possibility of using non-trivial quantum mechanical effects, such as coherence and interference, to enhance molecular function. This possibility is hindered by decoherence processes that prevent matter from fully exhibiting its quantum features. In this talk, I will summarize our progress understanding decoherence in molecular processes, and in particular electronic decoherence. I will discuss the basic mechanisms for electronic coherence loss, methods to quantify the decoherence, and a general theory of decoherence timescales. The talk with conclude with some novel prospects on the possibility of using lasers to control electronic decoherence in molecules.






Ignacio Franco (University of Rochester)

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Other Thu, 11 Oct 2018 18:15:53 -0400 2018-10-11T04:00:00-04:00 2018-10-11T05:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
STEM Info Session (October 11, 2018 4:00pm) https://events.umich.edu/event/56404 56404-13896800@events.umich.edu Event Begins: Thursday, October 11, 2018 4:00pm
Location: Modern Languages Building
Organized By: Center for Global and Intercultural Study

Interested in science, technology, engineering, and math?

Join Senior Intercultural Program Advisor Sarah Pauling and Intercultural Program Advisor, Cristina Zamarron for an information session for current students interested in the following study abroad programs:

AFRICA & THE MIDDLE EAST
• Wildlife Management Studies in Tanzania

THE AMERICAS
•Environment and Sustainable Development in San Jose, Costa Rica

ASIA-PACIFIC
•EcoQuest Field Studies in Whakatiwai, New Zealand
•Frontiers Abroad- Geology, and Earth Systems Science

EUROPE
•Budapest Semester in Mathematics
•DIS Stockholm/Copenhagen
•STEM Summer Research Program
•University Study in the UK— London School of Economics (Summer)

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Meeting Thu, 04 Oct 2018 14:50:57 -0400 2018-10-11T16:00:00-04:00 2018-10-11T17:00:00-04:00 Modern Languages Building Center for Global and Intercultural Study Meeting PHOTO
Analytical 3rd Year Student Seminars (October 12, 2018 4:00pm) https://events.umich.edu/event/54984 54984-13662980@events.umich.edu Event Begins: Friday, October 12, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry








Kunal Khanna(Walter Lab) , Shane Wells(Kennedy Lab)

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Other Fri, 12 Oct 2018 18:15:50 -0400 2018-10-12T16:00:00-04:00 2018-10-12T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: "Carbonaceous nanoparticle and biological membrane - a molecular dynamic perspective" (October 12, 2018 4:00pm) https://events.umich.edu/event/53433 53433-13381402@events.umich.edu Event Begins: Friday, October 12, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: Nanoparticles have been widely utilized in many health-related fields, such as drug delivery, cancer therapy, biolabeling, and biosensors. Studies on the molecular details of the interaction between nanoparticles and biological nanosystems are crucial for obtaining information on the mechanisms of the possible outcomes of these nanomaterials, such as cytotoxicity, biological accumulation, and long-term effects. In this talk, we will introduce a recent model that we are developing to help understand and predict the interaction between carbonaceous nanoparticles and biological membrane based on the molecular structural information. The model presents in detail how molecular properties of nanoparticles such as size, shape and chemical properties affect the organization of the nanoparticles in the membrane, as well how different components in the membrane affect the selectivity on nanoparticles. This critical information is helpful for designing engineered nanoparticles that are biocompatible, bioavailable for different environmental and biological applications.

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Workshop / Seminar Fri, 28 Sep 2018 11:27:26 -0400 2018-10-12T16:00:00-04:00 2018-10-12T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Desmond Liu
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (October 15, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656661@events.umich.edu Event Begins: Monday, October 15, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-10-15T14:00:00-04:00 2018-10-15T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Moving beyond Methionine Synthase: New Insights into Cobalamin-Dependent Methyltransferase Reactions (October 15, 2018 4:00pm) https://events.umich.edu/event/51068 51068-11953412@events.umich.edu Event Begins: Monday, October 15, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Biological methylation underpins myriad cellular processes through the modification of proteins, lipids, nucleic acids, heavy metals, and a variety of small organic molecules. In the vast majority of these reactions, the appended methyl group derives from S-adenosylmethionine (SAM) and is attached most often to nitrogen and oxygen nucleophiles through a polar SN2 mechanism, although carbon, sulfur, and a variety of other nucleophilic atoms also receive SAM-derived methyl groups. Recently, it has become apparent that SAM is used to methylate non-reactive carbon and phosphorus atoms by mechanisms involving radical intermediates. To date, these reactions are catalyzed exclusively by radical SAM enzymes, a superfamily of enzymes that use an iron-sulfur (Fe-S) cluster to catalyze a reductive cleavage of SAM to methionine and the potent oxidant 5’-deoxyadenosin 5’-radical (5’-dA•). There are at least five subclasses of radical SAM methylases. Class B methylases represent the largest subclass, and use cobalamin to methylate both sp2- and sp3-hybridized carbon centers or phosphinate phosphorus centers during the biosynthesis of numerous biomolecules, including natural products with antibiotic and anticancer activities. This lecture will focus on two Class B radical SAM methylases involved in the biosynthesis of antibacterial agents. Fom3, which performs a key step in the biosynthesis of the broad-spectrum antibiotic fosfomycin, catalyzes the methylation of the sp3-hybridized C2’’ carbon of cytidylyl-2-hydroxyethylphosphonate to yield cytidylyl-2-hydroxypropylphosphonate. By contrast, TsrM catalyzes the first committed step in the biosynthesis of the quinaldic acid moiety of the thiopeptide antibiotic thiostrepton, which is the methylation of the sp2-hybridized C2 carbon of the indole ring of L-tryptophan. As will be discussed, while both Fom3 and TsrM are cobalamin-dependent radical SAM methylases, they use two distinctly different strategies to catalyze their reactions.














Squire Booker (The Pennsylvania State University)

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Other Mon, 15 Oct 2018 18:15:46 -0400 2018-10-15T16:00:00-04:00 2018-10-15T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (October 16, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656572@events.umich.edu Event Begins: Tuesday, October 16, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-10-16T14:00:00-04:00 2018-10-16T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Understanding spliceosome mechanism with small molecule inhibitors (October 16, 2018 4:00pm) https://events.umich.edu/event/51622 51622-12173406@events.umich.edu Event Begins: Tuesday, October 16, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The spliceosome is the cellular machinery responsible for removing introns from gene transcripts by the process of splicing, and a variety of cancers accumulate specific mutations that alter spliceosome activity. In particular, the spliceosome protein SF3B1, which helps identify the boundary of introns, is frequently mutated in hematologic cancers. Notably, SF3B1 is also the common target of several bacterial natural products that were first identified in screens for drugs that kill cancer cells. We are investigating the structure-activity relationships of three different classes of SF3B1 inhibitors. Some analogs that are inactive for splicing inhibition nevertheless compete with their active counterparts, which suggests that drug binding alone is not sufficient to interfere with splicing. Furthermore, the competition of inactive and active compounds holds between different classes of inhibitors, supporting shared pharmacophores. We are now using these compounds as tools to explore the role of SF3B1 in splice site identification and fidelity, as well as in structural transitions required for spliceosome assembly.












Melissa Jurica (UC Santa Cruz)

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Other Tue, 16 Oct 2018 18:15:46 -0400 2018-10-16T16:00:00-04:00 2018-10-16T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (October 17, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656616@events.umich.edu Event Begins: Wednesday, October 17, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-10-17T14:00:00-04:00 2018-10-17T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Analytical 3rd Year Student Seminars (October 17, 2018 4:00pm) https://events.umich.edu/event/54985 54985-13662981@events.umich.edu Event Begins: Wednesday, October 17, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Colleen Riordan(Bailey Lab) , Shannon Wetzler(Bailey Lab)

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Other Wed, 17 Oct 2018 18:15:47 -0400 2018-10-17T16:00:00-04:00 2018-10-17T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Converting Anti-Aromatic to Aromatic: A Method to Access Boron-Containing Heteroarenes (October 18, 2018 12:00pm) https://events.umich.edu/event/55724 55724-13777498@events.umich.edu Event Begins: Thursday, October 18, 2018 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The concept of inorganic doping by substituting boron and a lone-pair bearing heteroatom in place of a C=C unit in carbon-based aromatics is an attractive method to alter the electronic properties. Our group has been working on developing a facile route to access inorganic/organic hybrid aromatic species via ring insertion reactions with anti-aromatic BC4 heterocycles, namely boroles. The insertion chemistry has been effective for the preparation of 1,2-azaborine, 1,2-phoaphaborine, 1,2-oxaborine, and 1,2-thiaborine heteroarenes which all have lower band gaps, red-shifted absorbances, and larger dipole moments in comparison to their carbonaceous counterpart, benzene. Ongoing efforts are focused on enhancing the electronic properties of these boracycles to explore their utility in electronic materials. Our current strategy is to extend conjugation in the inorganic/organic hybrid arenes by utilizing borole-based starting materials with conjugation installed. The mechanisms of these reactions and properties of the boracycles will be discussed.






Caleb Martin (Baylor University)

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Other Thu, 18 Oct 2018 18:15:47 -0400 2018-10-18T12:00:00-04:00 2018-10-18T13:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
"Development of New Catalytic Reactions Involving the Activation of Traditionally Inert Bonds" (October 19, 2018 4:00pm) https://events.umich.edu/event/52879 52879-13094886@events.umich.edu Event Begins: Friday, October 19, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Organic molecules contain a variety of chemical bonds. Organic synthesis involves the cleavage of a chemical bond and the formation of a new chemical bond. However, not all of the chemical bonds in organic molecules have been used in organic synthesis. Thus, organic synthesis is heavily dependent on the reactivity of chemical bonds. If so-called unreactive bonds were to be used directly in organic synthesis, new possibilities for developing new synthetic methodologies would arise. We have utilized, not only the activation of C-H bonds, but also the activation of unreactive single bonds, such as C-C, C-O, C-N, and C-F bonds, and the activation of C-C triple bonds and C-O double bonds, in our quest to develop new types of transformations that will lead to further diversification in the field of organic synthesis.
















Naoto Chatani (Osaka University)

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Other Fri, 19 Oct 2018 18:15:48 -0400 2018-10-19T16:00:00-04:00 2018-10-19T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: “Protons to patients: evaluating the role of the chloride transporter ClC-7 in lysosomal function” (October 19, 2018 4:00pm) https://events.umich.edu/event/53434 53434-13381403@events.umich.edu Event Begins: Friday, October 19, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: Lysosomes are essential focal points of cellular metabolism, digesting a wide range of macromolecules provided by endocytosis or autophagy. To this end, lysosomes rely on their highly acidic luminal pH to promote the function of their many enzymes, a pH generated by the action of a v-Type proton pumping ATPase. Since this transporter is electrogenic, parallel ion movements must occur to dissipate the generated membrane potential and promote bulk proton flux. I will present evidence that the Cl-/H+ antiporter, ClC-7, plays this role, moving Cl- to dissipate the lysosomal transmembrane voltage. However, the function of ClC-7 has been controversial, with conflicting reports on its contribution to lysosomal acidification. All heretofore known patients with ClC-7 functional mutations have varying degrees of the same disease, with osteopetrosis sometimes associated with lysosomal storage disease. Here, we report on two patients with a novel disease manifested as widespread lysosomal dysfunction but no bone abnormalities, who both have the same missense mutation in ClC-7. We find that fibroblasts from both patients have acidification abnormalities and that heterologously expressed human ClC-7 carrying this mutation displays a novel phenotype under electrophysiological measurements. These findings provide strong support for an important role of ClC-7 in the lysosomal acidification process and suggest opportunities for therapies for these patients.

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Workshop / Seminar Wed, 26 Sep 2018 15:30:54 -0400 2018-10-19T16:00:00-04:00 2018-10-19T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Joe Mindell
GSK Info Session (October 22, 2018 11:15am) https://events.umich.edu/event/56687 56687-13963071@events.umich.edu Event Begins: Monday, October 22, 2018 11:15am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Beth Knapp-Reed, PhD

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Workshop / Seminar Mon, 22 Oct 2018 18:15:46 -0400 2018-10-22T11:15:00-04:00 2018-10-22T12:15:00-04:00 Chemistry Dow Lab Department of Chemistry Workshop / Seminar Chemistry Dow Lab
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (October 22, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656662@events.umich.edu Event Begins: Monday, October 22, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-10-22T14:00:00-04:00 2018-10-22T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Ozone, Carbon Dioxide, and Unusual Kinetic Isotope Effects: From the Stratosphere to the Laboratory and Back Again (October 22, 2018 4:00pm) https://events.umich.edu/event/53008 53008-13181201@events.umich.edu Event Begins: Monday, October 22, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The discovery of unusual oxygen isotope compositions in ozone and carbon dioxide by Mauersberger and co-workers and Thiemens and co-workers in the 1980s and 1990s has been followed by the challenges of understanding the chemical physics of the non-standard kinetic isotope effects on a molecular level and how they play out on a global scale, with the promise of providing new isotopic tracers of ozone production and transport in the stratosphere and the rates of uptake of atmospheric carbon dioxide by the biosphere. In this talk, I will highlight laboratory experiments (including crossed molecular beam experiments on O+O2 and O+CO2 and bulk photochemistry experiments on CO2 and O2 mixtures) and new stratospheric isotope measurements on air collected by aircraft and balloon flights that provide new insight into and constraints on the chemical physics of these unusual isotope effects needed to support their growing application to solving problems in the Earth and environmental sciences across a variety of disciplines.










Kristie Boering (University of California Berkeley)

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Other Mon, 22 Oct 2018 18:15:46 -0400 2018-10-22T16:00:00-04:00 2018-10-22T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (October 23, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656573@events.umich.edu Event Begins: Tuesday, October 23, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-10-23T14:00:00-04:00 2018-10-23T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Energy Storage: Predicting the Future is a lot Easier These Days (October 24, 2018 11:00am) https://events.umich.edu/event/56970 56970-14057149@events.umich.edu Event Begins: Wednesday, October 24, 2018 11:00am
Location: Michigan Memorial Phoenix Project
Organized By: University of Michigan Energy Institute

About Sue Babenic: Sue Babinec is a Senior Advisor at the Advanced Research Projects Agency-Energy (ARPA-E) and is responsible for their energy storage portfolio–both transportation and grid. In the commercialization aspects of this role she prepares breakthrough energy technology teams for the transition from lab to market by coaching on patents, manufacturing process design/economics and partnerships with customers/funding groups. In her strategy role she helps to shape improved approaches, across a broad spectrum, towards maximizing positive impact of ARPA-E technologies on the US competitiveness.

Talk abstract:
The long awaited emergence of ES as an economically sound enabler of electrified trans- portation, often considered pure speculation, is now a reality. Li-Ion is satisfying the many criteria for ICE parity which was originally set by DOE. Its high volume manufacturing now gives rise to lower costs which ensures continued commoditization and widespread adoption, albeit not based on US as the market lead. Thus the formerly nascent industry is settling in to predictable mature behaviors. For the reimagined GRID of the future, cost effective wind and solar renewables coupled to the now cost effective Li-Ion storage are beginning to beat the usual approaches for electricity generation - without subsidies. In this presentation we will look at the evolution and some of the details of this pres- ent case, the remaining performance shortcomings, and how they might be met. Topics will include global manufacturing supply/demand trends, economics of scale, remaining technology gaps and technical challenges, including ARPA-E breakthrough approaches for both transportation and stationary. Our problem has transitioned from grappling to bring Li-Ion to the world to avoiding its total technology lock-in, which may ultimately thwart the next generation of progress.

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Lecture / Discussion Mon, 22 Oct 2018 09:52:36 -0400 2018-10-24T11:00:00-04:00 2018-10-24T12:00:00-04:00 Michigan Memorial Phoenix Project University of Michigan Energy Institute Lecture / Discussion Energy Institute promo image
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (October 24, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656617@events.umich.edu Event Begins: Wednesday, October 24, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-10-24T14:00:00-04:00 2018-10-24T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Analytical 3rd Year Student Seminars (October 24, 2018 4:00pm) https://events.umich.edu/event/54986 54986-13662982@events.umich.edu Event Begins: Wednesday, October 24, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Emily Mordan(Bailey Lab) , Kelcie Zegalia(Kennedy Lab)

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Other Wed, 24 Oct 2018 18:15:48 -0400 2018-10-24T16:00:00-04:00 2018-10-24T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Incorporation of Fluorescent Dye Molecules into Molecular Scaffolds: From Molecular Sensors to Switchable Catalysts (October 24, 2018 4:00pm) https://events.umich.edu/event/55302 55302-13716035@events.umich.edu Event Begins: Wednesday, October 24, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Increased environmental and impurity restrictions on consumer products, also the desire to reduce the cost and energy requirements of chemical transformations, have established a critical need for the development of more selective and efficient catalysts. An attractive approach to addressing this need is the use of catalysts that can be altered through post-synthetic modifications. Several commonly employed methods to change catalyst reactivity post-synthesis include the manipulation of pH, photoactivation, or even changes in solvent. This talk will discuss the synthesis, characterization, and reactivity of fluorescent dye-containing main group compounds that are capable of exhibiting a colorimetric response upon binding substrate molecules. This talk will also describe the incorporation of fluorescent dye-containing ligands into metal and main group complexes for switchable reactivity.
















Zachariah Heiden (Washington State University)

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Other Wed, 24 Oct 2018 18:15:48 -0400 2018-10-24T16:00:00-04:00 2018-10-24T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
2018 Massey TBI Regional Conference (October 25, 2018 8:30am) https://events.umich.edu/event/55950 55950-13811923@events.umich.edu Event Begins: Thursday, October 25, 2018 8:30am
Location: Junge Champions Center
Organized By: Michigan Center for Integrative Research in Critical Care (MCIRCC)

Supported by the Massey Foundation, the Massey TBI Regional Conference aims to improve the outcomes of those who suffer severe traumatic brain injuries by supporting technology development, and translational and clinical research that impacts the “golden hours” of care. Through lectures, a poster session, and scientific presentations from funded Massey TBI Grand Challenge teams, we will explore the diagnosis, monitoring, and treatment of this critical injury.
Learn more and register today at https://mcircc.umich.edu/events-training/regional-conference.

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Conference / Symposium Tue, 25 Sep 2018 08:42:26 -0400 2018-10-25T08:30:00-04:00 2018-10-25T16:30:00-04:00 Junge Champions Center Michigan Center for Integrative Research in Critical Care (MCIRCC) Conference / Symposium Massey TBI Regional Conference Header Image
C-H and C-O functionalization via radical chaperones (October 25, 2018 4:00pm) https://events.umich.edu/event/52741 52741-12986895@events.umich.edu Event Begins: Thursday, October 25, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our research is focused on harnessing the untapped reactivity of cheap and abundant chemical feedstocks in organic synthesis to enable the late-stage functionalization of complex natural products and other medicinally-relevant molecules. We have recently developed new approaches for selective C-H and C-O functionalization of alcohols and carbonyls, using a combination of radical (1e-) and closed shell (2e-) processes that act in concert with one another. These new radical chaperone strategies have enabled the development of chemical transformations with applications within molecules of biological and industrial interest.










David Nagib (The Ohio State University)

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Other Thu, 25 Oct 2018 18:15:46 -0400 2018-10-25T16:00:00-04:00 2018-10-25T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Solving the Opioid Crisis - with Opioids (October 25, 2018 4:00pm) https://events.umich.edu/event/57023 57023-14068328@events.umich.edu Event Begins: Thursday, October 25, 2018 4:00pm
Location: 1100 North University Building
Organized By: U-M College of Pharmacy

Join guest lecturer Stephen Husbands, PhD, Professor, Department of Pharmacy and Pharmacology; Centre for Therapeutic Innovation at the University of Bath, for a lecture titled, "Solving the Opioid Crisis - with Opioids."

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Lecture / Discussion Tue, 23 Oct 2018 14:18:39 -0400 2018-10-25T16:00:00-04:00 2018-10-25T17:00:00-04:00 1100 North University Building U-M College of Pharmacy Lecture / Discussion 1100 North University Building
Analytical 3rd Year Student Seminars (October 26, 2018 4:00pm) https://events.umich.edu/event/54987 54987-13662983@events.umich.edu Event Begins: Friday, October 26, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Cole Chapman(Bailey Lab) , John Orlet(Bailey Lab)

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Other Fri, 26 Oct 2018 18:15:46 -0400 2018-10-26T16:00:00-04:00 2018-10-26T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: "The ParA/MinD family of ATPases make waves to position DNA, cell division, and organelles in bacteria" (October 26, 2018 4:00pm) https://events.umich.edu/event/56105 56105-13832575@events.umich.edu Event Begins: Friday, October 26, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: Positional information in eukaryotic cells is mainly orchestrated by cytoskeletal highways and their associated motor proteins like Myosin, Kinesin, and Dynein. Bacteria don’t have linear motors, so how are they spatially organized? I will be discussing three members of the ParA/MinD family of ATPases that are part of self-organizing systems that put things in their place in cells across the microbial world. I will first present the ATPase called ParA, which is part of the most common DNA-segregation system in bacteria. ParA proteins form dynamic waves on the nucleoid to position chromosomes and plasmids in opposite cell-halves so that they are faithfully inherited after cell division. I will then discuss the ATPase called MinD, which is part of a system that forms oscillatory waves on the inner membrane. The oscillation aligns cell division at mid-cell so that daughter cells are equal in size. Finally, I will introduce a new member of this ATPase family we call McdA, which is part of an organelle trafficking system in bacteria. Yes. Bacteria have organelles. Our work is shedding light on what seems to be a general mode of subcellular organization in bacteria – dynamic protein gradients surfing biological surfaces to impart positional information for a wide variety of fundamental biological processes. My new lab focuses on subcellular organization in bacteria with a strong emphasis towards reconstituting the self-organizing activities of these systems in a cell-free setup using purified and fluorescent labeled components. By visualizing the biochemistry driving self-organization outside the cell we are able to provide comprehensive molecular mechanisms that explain subcellular organization inside the cell.

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Workshop / Seminar Tue, 02 Oct 2018 16:14:04 -0400 2018-10-26T16:00:00-04:00 2018-10-26T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Anthony Vecchiarelli
Ultrafast Studies of Single Plasmonic Nanostructures (October 26, 2018 4:00pm) https://events.umich.edu/event/54352 54352-13574513@events.umich.edu Event Begins: Friday, October 26, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The optical properties of metal nanostructures are dominated by plasmon resonances, which are strong collective motions of the conduction electrons. These resonances are at the heart of a variety of schemes for molecular sensing and plasmon enhanced catalysis. However, the dynamics of plasmons can be difficult to study due to the distribution of particle sizes and shapes present in typical samples. In this talk I will describe single particle experiments that provide information about the ultrafast energy relaxation processes of plasmonic nanostructures, and how these structures interact with their environment. Examples of the processes that have been studied include the creation of novel hybrid states through coupling between plasmons and excitons, and the strange case of viscoelastic effects in the damping of vibrational modes of metal nanostructures.










Gregory Hartland (University of Notre Dame)

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Other Fri, 26 Oct 2018 18:15:45 -0400 2018-10-26T16:00:00-04:00 2018-10-26T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (October 29, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656663@events.umich.edu Event Begins: Monday, October 29, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-10-29T14:00:00-04:00 2018-10-29T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Chemistry - Biology Interface Training Program Symposium (October 30, 2018 1:00pm) https://events.umich.edu/event/56808 56808-14008216@events.umich.edu Event Begins: Tuesday, October 30, 2018 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry








Tarun Kapoor

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Other Tue, 30 Oct 2018 18:15:42 -0400 2018-10-30T13:00:00-04:00 2018-10-30T18:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (October 30, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656574@events.umich.edu Event Begins: Tuesday, October 30, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-10-30T14:00:00-04:00 2018-10-30T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Chemistry at the Intersection of Self-Assembly and Energy Conversion (October 30, 2018 4:00pm) https://events.umich.edu/event/52611 52611-12901950@events.umich.edu Event Begins: Tuesday, October 30, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry



Nature uses a complex array of chromophores, optimally organized both spatially and electronically, to carry out photoinduced energy and electron transfer from pigment molecules to a reaction center. The fundamental processes underpinning photosynthesis provide the basis for artificial solar conversion systems that include photovoltaic cells, photoanodes and photocathode catalysts to generate electricity or fuels. It is the supramolecular arrangement of multiple chromophores that results in the emergent properties associated with natural light harvesting complexes, including enhanced absorption, efficient energy transfer between pigments, and electron-transfer. We are interested in self-assembled discrete metal-organic assemblies containing multiple chromophores as functional models of supramolecular light harvesting architectures. Specifically, we are actively designing systems to identify the optimal alignment, spacing, and electronic structure to enable directional EnT and photoredox chemistry while maximizing broadband absorption matched to the solar flux. The formation of structurally complex metal-organic polygons, polyhedra, and prisms (MOPs) is greatly facilitated by coordination-driven self-assembly methods which furnish them in single, one-pot reactions. An ever-growing library of organic ligands (donors) and metal/organometallic complexes with substitutionally labile coordination sites (acceptors) serves as the basis for a suite of metallacycles and cages characterized by their well-defined internal cavities and predictable topologies. The rigid organic backbones that once served solely as structural elements have more recently been exploited for their ability to impart interesting photophysical properties to their parent MOPs. Strategies include tethering pendant fluorophores through covalent coupling chemistry and selecting inherently emissive building blocks, with an emphasis on exploiting Ru, Ir, and Pt-based complexes.








Timothy Cook (University of Buffalo)

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Other Tue, 30 Oct 2018 18:15:42 -0400 2018-10-30T16:00:00-04:00 2018-10-30T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (October 31, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656618@events.umich.edu Event Begins: Wednesday, October 31, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-10-31T14:00:00-04:00 2018-10-31T16:00:00-04:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Analytical 3rd Year Student Seminars (October 31, 2018 4:00pm) https://events.umich.edu/event/54988 54988-13662984@events.umich.edu Event Begins: Wednesday, October 31, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Bonsall Robert(McCrory Lab) , Geng Luqan(Kennedy Lab)

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Other Wed, 31 Oct 2018 18:15:41 -0400 2018-10-31T16:00:00-04:00 2018-10-31T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Expanding the Synthetic Biology Toolbox for Tropane and Granatane Alkaloids (November 2, 2018 12:00pm) https://events.umich.edu/event/56106 56106-13832577@events.umich.edu Event Begins: Friday, November 2, 2018 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Eran Pichersky

John D'Auria
Assistant Professor, Department of Chemistry & Biochemistry
Texas Tech University

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Workshop / Seminar Thu, 04 Oct 2018 10:14:55 -0400 2018-11-02T12:00:00-04:00 2018-11-02T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar plant and chemical diagram
Undergraduates Teaching Chemistry Through Outreach (November 2, 2018 12:00pm) https://events.umich.edu/event/53786 53786-13461543@events.umich.edu Event Begins: Friday, November 2, 2018 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Ellen Yezierski (Miami University)

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Other Fri, 02 Nov 2018 18:15:42 -0400 2018-11-02T12:00:00-04:00 2018-11-02T00:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
22nd Annual Mathematics Career & Graduate Program Conference (November 2, 2018 1:00pm) https://events.umich.edu/event/56946 56946-14032743@events.umich.edu Event Begins: Friday, November 2, 2018 1:00pm
Location: East Hall
Organized By: Department of Mathematics

All Students Welcome! Speak with U-M Mathematics Alumni and representatives from business, industry, education and financial and actuarial occupations, as well as U-M graduate programs. Faculty advisors will also be on hand to discuss declaring a major or minor in Mathematics! Refreshments Provided!

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Careers / Jobs Fri, 19 Oct 2018 17:08:05 -0400 2018-11-02T13:00:00-04:00 2018-11-02T16:00:00-04:00 East Hall Department of Mathematics Careers / Jobs Career Fair
Innovative Strategies for Nonconventional Water Splitting and Beyond (November 2, 2018 4:00pm) https://events.umich.edu/event/53785 53785-13461542@events.umich.edu Event Begins: Friday, November 2, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

One of the challenges to realize large-scale H2 production from water electrolysis is the lack of competent and inexpensive electrocatalysts. Our group recently discovered that surface modification of metallic nickel with nitrogen resulted in a superior electrocatalyst for H2 evolution under neutral condition, rivaling the performance of the state-of-the-art platinum-based catalysts. In addition, since water oxidation is more kinetically challenging while its product O2 is not of significant value, we are also interested in exploring alternative oxidation reactions which can not only provide electrons for H2 evolution at the cathode but also yield value-added organic products at the anode. Within this context, biomass-derived intermediate compounds are found to be suitable candidates for electrocatalytic upgrading, which can be integrated with H2 production under alkaline conditions. Finally, a new electrolyzer design for decoupled water splitting and organic transformation will be presented, which is able to substantially reduce voltage inputs and mitigate the H2/O2 mixing issue commonly encountered in conventional water electrolysis.












Yujie Sun (University of Cincinnati)

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Other Fri, 02 Nov 2018 18:15:41 -0400 2018-11-02T16:00:00-04:00 2018-11-02T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Titles: "Quantitative analysis of the spindle assembly checkpoint (SAC)", Chu Chen and "Pattern Formation in 2D Tissues via Mechanics: From Juvenile Zebrafish to Human Embryonic Stem Cells", Hayden Nunley (November 2, 2018 4:00pm) https://events.umich.edu/event/53435 53435-13381404@events.umich.edu Event Begins: Friday, November 2, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstracts:
Chu Chen - In mammalian cells, accurate chromosome segregation during mitosis requires that kinetochores of sister chromatids attach to microtubules emanating from opposite spindle poles. In the absence of kinetochore-microtubule attachment, the spindle assembly checkpoint (SAC) is activated to delay anaphase onset. Over the past two decades, researchers have basically revealed the fundamental biochemical pathway of SAC signaling. However, how SAC effectively halts mitosis progression in the presence of very few unattached kinetochores is less addressed. In this talk, quantitative evidence will be presented which suggest the presence of synergistic actions in SAC. Hypothesis about the underlying mechanism and preliminary data from ongoing validation experiments will also be discussed. This cooperativity may enable a single unattached kinetochore to produce a strong enough signal.-

and

Hayden Nunley - Many epithelial tissues are composed of several types of cells with distinct functions. For proper functioning of the tissues, it is often important that the different types of cells form a spatial pattern. The specific biological details of how the cells interact to form these patterns are often not fully understood. To study the developmental processes in the absence of detailed biological information, it is useful to test which simplified physical models are consistent with experimental observations. With insights from these models, we identify specific candidate proteins or cellular structures necessary for the interaction, and generate predictions of how specific manipulations will affect tissue patterning. In this spirit, we will discuss the formation of a crystal of cone photoreceptors in juvenile zebrafish retinae. We find that the structure and arrangement of defects in the tissue are consistent with a purely mechanical model in which cones of one specific type interact with other cones of the same type at short range. We identify a specific cellular structure as a candidate for mediating this interaction. We will also discuss neural fate specification in human embryonic stem cell colonies. To study this pattern which has a length scale that does not scale with colony size, we propose a model in which cells respond to mechanical stresses by altering their contractility.

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Workshop / Seminar Tue, 16 Oct 2018 11:24:41 -0400 2018-11-02T16:00:00-04:00 2018-11-02T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (November 5, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656664@events.umich.edu Event Begins: Monday, November 5, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-11-05T14:00:00-05:00 2018-11-05T16:00:00-05:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
John Essigmann Panel Discussion (November 5, 2018 4:00pm) https://events.umich.edu/event/53083 53083-13222317@events.umich.edu Event Begins: Monday, November 5, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry
















John Essigmann (Massachusetts Institute of Technology)

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Other Mon, 05 Nov 2018 18:15:39 -0500 2018-11-05T16:00:00-05:00 2018-11-05T18:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (November 6, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656575@events.umich.edu Event Begins: Tuesday, November 6, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-11-06T14:00:00-05:00 2018-11-06T16:00:00-05:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Unconventional Building Blocks for Functional Polymeric Materials (November 6, 2018 4:00pm) https://events.umich.edu/event/52163 52163-12502488@events.umich.edu Event Begins: Tuesday, November 6, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The Klausen group designs and synthesizes unconventional molecular building blocks
for the construction of diverse functional polymeric architectures. Motivated by the conviction that the synthesis of new materials drives the discovery of new applications, this talk will describe the synthesis and polymerization of novel hybrid inorganic-organic monomers. The materials we prepare are expected to find application in energy science as earth abundant quantum materials or as plastics with finely controlled physical properties.
The semiconductor silicon has revolutionized life in the last century, from the development of computer chips to the discovery of solar cells that make telecommunication satellites possible. The frontier for silicon research and development is at the nanoscale. The incredible potential of nanoscale silicon arises from the attractive properties it shares with bulk silicon, such as earth abundance and low precursor toxicity, and the distinctive optical and electronic properties emerging at small sizes. This talk describes the design and synthesis of new molecular forms of silicon, as well as the characterization of materials properties and the fabrication of electronic devices based on molecular silicon.
BN 2-Vinylnaphthalene (BN2VN) is a solution to a long-standing challenge in polymer chemistry, the copolymerization of nonpolar and polar monomers. Though the incorporation of polar functionality into nonpolar polymers is an essential strategy for modulating physical properties, challenges in their direct copolymerization include phase separation, significant differences in reactivity, and the limited compatibility of polar functional groups with polymerization catalysts. We show that BN2VN retains the reactivity of styrene, while post- polymerization modification of the C-B bond provides hydroxyl-functionalized polymers, or styrene-vinyl alcohol (SVA) copolymers.


















Bekka Klausen (Johns Hopkins University)

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Other Tue, 06 Nov 2018 18:15:40 -0500 2018-11-06T16:00:00-05:00 2018-11-06T17:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (November 7, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656619@events.umich.edu Event Begins: Wednesday, November 7, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-11-07T14:00:00-05:00 2018-11-07T16:00:00-05:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Symmetry Making and Breaking in Seeded Growth of Metal Nanocrystals (November 8, 2018 4:00pm) https://events.umich.edu/event/52487 52487-12809234@events.umich.edu Event Begins: Thursday, November 8, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Crystal growth theory predicts that heterogeneous nucleation will occur preferentially at defect sites, such as the vertices rather than the faces of shape-controlled seeds. Platonic metal solids are generally assumed to have vertices with nearly identical chemical potentials, and also nearly identical faces, leading to the useful generality that heterogeneous nucleation preserves the symmetry of the original seeds in the final product. This presentation will discuss how this generality can be used to access stellated metal nanocrystals with high and tunable symmetries for applications in plasmonics. This presentation will also discuss the limits of this generality in the extreme of low supersaturation. A strategy for favoring localized deposition that differentiates between both different vertices and different edges or faces, i.e., regioselective deposition, will be demonstrated. Such regioselective heterogeneous nucleation was achieved at low supersaturation by a kinetic preference for high-energy defect-rich sites over lower-energy sites. This outcome was enhanced by using capping agents to passivate facet sites where deposition was not desired. Collectively, the results presented provide a model for breaking the symmetry of seeded growth and for achieving regioselective deposition.






















Sara Skrabalak (Indiana University)

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Other Thu, 08 Nov 2018 18:15:44 -0500 2018-11-08T16:00:00-05:00 2018-11-08T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: “Discovering a new broad antiviral inhibitor” (November 9, 2018 4:00pm) https://events.umich.edu/event/53438 53438-13381407@events.umich.edu Event Begins: Friday, November 9, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: The human ESCRT protein machinery is required for membrane remodeling events including multivesicular body biogenesis, cellular abscission, and viral budding. Specifically, the Pro-Thr-Ala-Pro (PTAP) motif of viral Gag proteins targets the ESCRT-I complex via a direct interaction with Tsg101 (tumor susceptibility gene 101). This interaction is necessary for the viral Gag proteins to be recruited to the membrane. Naturally this interaction site has been the target for designing anti-viral drugs by mimicking the PTAP motif. Recently we identified a small molecule inhibitor of HIV budding, which we expected to bind to the PTAP recognition site of Tsg101. This molecule belongs to a family of proton pump inhibitors that are clinically used to treat acid reflux. Initial characterization using solution NMR indicated that the inhibitor interacts with Tsg101 outside of the PTAP recognition site. The structure of Tsg101 and a small molecule inhibitor complex that we solved reveals a covalent interaction occurring at the ubiquitin (Ub) binding site of Tsg101. Tsg101’s main contribution to ESCRT-I function is in recognition of and binding to Ub-modified cargo. The fact that the inhibitor targeted ubiquitin-Tsg101 binding was significant, since this interaction was previously thought to have little influence on the HIV-1 life cycle. Using our new inhibitor as a tool, we uncovered the essential role of Ub-Tsg101 interaction to promote degradation of HIV-1 Gag protein in the cell and to block co-localization of Tsg101 and HIV-1 Gag at the plasma membrane required for budding. In addition, we also showed that Tsg101 has another binding site that can contact the second Ub moiety in K48 or K63 linked di-Ub molecules. This second Ub binding site on Tsg101 has a weaker affinity compared to the first site and its observation required the use of novel NMR methodology. Our recent results show the potential for development of broad spectrum antiviral inhibitor based on clinically approved proton pump inhibitors targeting Tsg101 and we also provided the first evidence for the important role of Tsg101 and di-Ub interaction in viral replication.

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Workshop / Seminar Wed, 03 Oct 2018 11:43:15 -0400 2018-11-09T16:00:00-05:00 2018-11-09T17:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Nico Tjandra
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (November 12, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656665@events.umich.edu Event Begins: Monday, November 12, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-11-12T14:00:00-05:00 2018-11-12T16:00:00-05:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
RNA tertiary structure and its role in molecular recognition: lessons from self-splicing group II introns and lncRNA molecules. (November 12, 2018 4:00pm) https://events.umich.edu/event/50829 50829-11876205@events.umich.edu Event Begins: Monday, November 12, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The vast majority of our gene products are noncoding RNA molecules, many of which have elaborate three-dimensional structures. Despite the importance of RNA tertiary structure in gene expression, the scope of our knowledge about RNA structure and molecular recognition is limited. This is largely due to the small number of high resolution RNA structures and a paucity of studies on small molecule recognition by RNA. To address this problem, we have focused on understanding the molecular architecture and catalytic mechanism of group II introns, which are RNAs that catalyze their own splicing. We have also used the catalytic activity of group II introns to carry out high throughput screening of small molecule inhibitors, which we have optimized and developed as antifungal agents. These studies have been complemented by parallel studies on other long noncoding RNAs that lack catalytic activity, with the goal of identifying approaches for understanding and targeting RNA tertiary structures within the large network of regulatory lncRNAs.








Anna Marie Pyle (Yale University)

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Other Mon, 12 Nov 2018 18:15:39 -0500 2018-11-12T16:00:00-05:00 2018-11-12T17:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (November 13, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656576@events.umich.edu Event Begins: Tuesday, November 13, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-11-13T14:00:00-05:00 2018-11-13T16:00:00-05:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
U-M Biological Station Information Session (November 13, 2018 6:00pm) https://events.umich.edu/event/56728 56728-13969946@events.umich.edu Event Begins: Tuesday, November 13, 2018 6:00pm
Location: Dana Building
Organized By: University of Michigan Biological Station

Undergrads: come learn about spring/summer courses and research opportunities at the U-M Biological Station! Featuring a student panel and scholarship/financial aid information.

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Rally / Mass Meeting Thu, 08 Nov 2018 11:38:36 -0500 2018-11-13T18:00:00-05:00 2018-11-13T19:00:00-05:00 Dana Building University of Michigan Biological Station Rally / Mass Meeting Sunrise on Douglas Lake
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (November 14, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656620@events.umich.edu Event Begins: Wednesday, November 14, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-11-14T14:00:00-05:00 2018-11-14T16:00:00-05:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Student Development of Information Literacy Skills during Problem-Based Organic Chemistry Laboratory Experiments: Research applied to Classroom Practice (November 14, 2018 2:00pm) https://events.umich.edu/event/56983 56983-14059366@events.umich.edu Event Begins: Wednesday, November 14, 2018 2:00pm
Location: Hatcher Graduate Library
Organized By: University Library

Ginger Schultz, Department of Chemistry at the University of Michigan, describes an investigation of student information-seeking behaviors during problem-based organic chemistry laboratory experiments. This study used discourse analysis of student planning sessions and student work to understand how students apply information literacy skills when solving organic chemistry problems. She then describes how their findings were used to inform the design of a set of online learning modules developed in collaboration with Dr. Ye Li to promote the development of skills in an organic chemistry context.

Dr. Ginger Shultz is an Assistant Professor in the Department of Chemistry at U-M. She completed her doctorate in polymer chemistry at the University of Oregon and transitioned to education-focused research through a teaching postdoc in Chemistry at U-M. In 2013 she was named a U-M Presidential Postdoctoral Fellow and she was hired as faculty in 2016. Shultz’s research is focused on investigating student learning in problem-based organic chemistry laboratory courses, how graduate students instructors develop teaching knowledge, and writing-based strategies for learning in STEM.

Emergent Research Series events are aimed at better understanding the new ways in which research relies on the work of libraries and information professionals, and where cutting-edge research pushes past what libraries currently support.

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Lecture / Discussion Tue, 06 Nov 2018 10:33:43 -0500 2018-11-14T14:00:00-05:00 2018-11-14T15:30:00-05:00 Hatcher Graduate Library University Library Lecture / Discussion Emergent Research image
Thesis Defense: "Synthesis and Electrochemical Characterization of Magnesium-Ion Battery Electrolytes" (November 14, 2018 2:00pm) https://events.umich.edu/event/57255 57255-14142072@events.umich.edu Event Begins: Wednesday, November 14, 2018 2:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Adam Crowe (Advisor: Prof. Bart M. Bartlett)

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Other Wed, 14 Nov 2018 18:15:37 -0500 2018-11-14T14:00:00-05:00 2018-11-14T15:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Distinguished University Professor Lecture, Presented by Dr. Gordon L. Amidon (November 14, 2018 4:00pm) https://events.umich.edu/event/57490 57490-14202428@events.umich.edu Event Begins: Wednesday, November 14, 2018 4:00pm
Location: Rackham Graduate School (Horace H.)
Organized By: U-M College of Pharmacy

Does the much-maligned carbon dioxide, a driving force behind global warming, deserve its bad rap?

In his upcoming Distinguished University Professor lecture, Gordon L. Amidon, PhD’71, will explore carbon dioxide from many angles, “the Good, the Bad, and the Ugly.”

The talk will take place at 4 p.m. on November 14 in the Rackham Amphitheatre. The lecture and reception that follows are free and open to the public.

Prof. Gordon L. Amidon is the William I. Higuchi Distinguished University Professor of Pharmaceutical Sciences. His research aims to understand the gastrointestinal factors that control drug absorption from an oral drug product.

“I will present a modest attempt to resurrect the image of carbon dioxide,” explains Amidon. “While global warming and the role that atmospheric gases play in the ‘green house’ effect has received considerable attention in the scientific and public press, I will point to the more positive role of carbon dioxide in evolution and in biology.”

Distinguished University Professorships recognize exceptional scholarly and/or creative achievements, national and international reputation, superior teaching and mentoring, and an impressive record of service. Each Professor delivers a lecture of their choosing during this event.

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Lecture / Discussion Wed, 07 Nov 2018 15:22:34 -0500 2018-11-14T16:00:00-05:00 2018-11-14T18:00:00-05:00 Rackham Graduate School (Horace H.) U-M College of Pharmacy Lecture / Discussion Rackham Graduate School (Horace H.)
Hydrocarbon Functionalization in Porous Materials (November 15, 2018 4:00pm) https://events.umich.edu/event/57177 57177-14124206@events.umich.edu Event Begins: Thursday, November 15, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Hydrocarbons are cheap and abundant feedstocks readily derived from both fossil fuels and emerging renewable resources. Despite their abundance, hydrocarbons have limited applications in chemical synthesis due to the inertness of C–H bonds towards both homolytic and heterolytic bond cleavage. I will share two very different approaches to the selective functionalization of simple hydrocarbons that address these challenges. First, I will highlight a bio-inspired approach to achieve selective alkane hydroxylation using iron-based metal–organic frameworks. The critical influence of both primary and secondary coordination sphere elements on catalyst reactivity, selectivity, and stability will be detailed. Second, I will describe the identification and characterization of a simple heterogeneous base catalyst that converts aromatic hydrocarbons, CO2, and methanol into the corresponding aromatic esters at elevated temperatures. The transformation occurs via a two-step, semi-continuous cycle, and represents the first hydrocarbon CO2 insertion process that does not consume any energy-intensive stoichiometric reagents.






Dianne Xiao, PhD (Stanford University)

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Other Thu, 15 Nov 2018 18:15:33 -0500 2018-11-15T16:00:00-05:00 2018-11-15T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
BD Technology Leadership Development Program Info Session (November 15, 2018 6:00pm) https://events.umich.edu/event/57625 57625-14246147@events.umich.edu Event Begins: Thursday, November 15, 2018 6:00pm
Location: Herbert H. Dow Building
Organized By: Graduate Society of Women Engineers

BD (Becton, Dickinson and Company), a leading global medical technology company, is seeking high-potential talent in the life sciences, engineering and computer science disciplines for the Technology Leadership Development Program (TLDP). The TLDP consists of three progressively more challenging rotations that span multiple businesses and geographic locations within the
company designed to strengthen the candidate’s technical expertise and leadership skills. Qualified candidates must possess a PhD or research-based thesis MS.
All Engineering and Life Science majors are encouraged to apply.
Dinner will be provided!

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Careers / Jobs Mon, 12 Nov 2018 12:04:43 -0500 2018-11-15T18:00:00-05:00 2018-11-15T19:00:00-05:00 Herbert H. Dow Building Graduate Society of Women Engineers Careers / Jobs Herbert H. Dow Building
Halogen Bonding in Single Electron Transfers to Initiate New Radical Reactions (November 16, 2018 4:00pm) https://events.umich.edu/event/53007 53007-13179050@events.umich.edu Event Begins: Friday, November 16, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Non-covalent halogen bonding has been utilized in biological systems to increase the binding affinities of synthetic drugs to receptor sites in the body. These weak interactions typically mimic hydrogen bonding but offer a hydrophobic alternative to the typical polar or charged groups that are present in natural biological systems. Recently, our lab has identified halogen bonding as an important feature of electron-transfer for initiating certain radical reactions. We have strong preliminary experimental and computational evidence demonstrating the importance of halogen bonding in the context of radical fluorination, and believe a generalized strategy may be applied to a wide range of free radical reactions including heteroarene alkylation and arylation.









Ryan Baxter (University of California at Merced)

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Other Fri, 16 Nov 2018 18:15:35 -0500 2018-11-16T16:00:00-05:00 2018-11-16T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: Unraveling the enigma of the translocator protein 18kD, TSPO. (November 16, 2018 4:00pm) https://events.umich.edu/event/53439 53439-13381408@events.umich.edu Event Begins: Friday, November 16, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract:
The precise physiological roles of the ancient and conserved membrane protein TSPO (otherwise known as the translocator protein 18kD or the peripheral benzodiazepine receptor) remain obscure. The original discovery of TSPO in mammals occurred when it was found as an additional binding site for benzodiazepine drugs. High expression in tissues involved in steroid hormone synthesis along with other evidence suggested a regulatory role in cholesterol uptake into mitochondria, especially under stress conditions. More recently, TSPO knockout mouse models show inconsistent characteristics that weaken this hypothesis, although some common features exist: the loss of TSPO increased lipid oxidation, decreased ATP synthesis and decreased mitochondrial membrane potential. Another common feature of TSPO across all kingdoms appears to be the ability to bind porphyrins, including heme and protoporphyrin IX, likely endogenous ligands. Yet despite decades of research, there is no consensus regarding the nature and mechanism of TSPO effects. In this talk, I will discuss the current state of the structural, biochemical, and physiological analyses that are beginning to reveal how TSPO functions.

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Workshop / Seminar Thu, 08 Nov 2018 14:14:53 -0500 2018-11-16T16:00:00-05:00 2018-11-16T17:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Michael Garavito
Thesis Defense: "Development of Strategies for the Synthesis of Heterocycles and Carbocycles; and Investigation of Chemistry Course Placement on Undergraduate Students" (November 19, 2018 1:00pm) https://events.umich.edu/event/57256 57256-14142073@events.umich.edu Event Begins: Monday, November 19, 2018 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Elsa Hinds (Advisor: Prof. John P. Wolfe)

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Other Mon, 19 Nov 2018 18:15:30 -0500 2018-11-19T13:00:00-05:00 2018-11-19T14:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (November 19, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656666@events.umich.edu Event Begins: Monday, November 19, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-11-19T14:00:00-05:00 2018-11-19T16:00:00-05:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Catalytic Manipulation of Reactivity and Selectivity at High-Valent Nuclei (November 19, 2018 4:00pm) https://events.umich.edu/event/57146 57146-14121949@events.umich.edu Event Begins: Monday, November 19, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

This presentation will examine aspects of reactivity and selectivity discovered through the exploration of the chemistry of high-valent nuclei [Au(III), Pt(IV), and I(III)]. The first part concerns two examples wherein transition metals are examined as substrates for catalytic reactions rather than in their traditional role as catalysts. Operating from this perspective, supramolecular catalysis of C(sp3)-C(sp3) reductive elimination and organoborane catalyzed C(sp3)-CF3 reductive elimination will be discussed, with the latter applied to [18F]-radiotrifluoromethylation. The second section will continue the focus on fluorination through the development of a new aryliodine catalyst for enantioselective olefin difluorination, exploring structural features that improve catalyst robustness and selectivity and enabling the preparation of chiral fluorinated building blocks.




Mark Levin, PhD (Harvard University)

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Other Mon, 19 Nov 2018 18:15:30 -0500 2018-11-19T16:00:00-05:00 2018-11-19T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar+Webinar "Community-based Environmental Monitoring for Public Health Action: the Imperial County (CA) Community Air Monitoring Network" (November 20, 2018 12:00pm) https://events.umich.edu/event/57585 57585-14220052@events.umich.edu Event Begins: Tuesday, November 20, 2018 12:00pm
Location: School of Public Health Bldg I and Crossroads and Tower
Organized By: Center for Midlife Science

Humberto Lugo (Community Science & Air Monitoring Coordinator, Comité Civico Del Valle) and Alexa Wilkie MHS, MS (Program Manager, CA Environmental Health Tracking Program/Tracking California) will present a seminar on Community-based Environmental Monitoring for Public Health Action: the Imperial County (CA) Community Air Monitoring Network. The seminar will be live streamed (Blue Jeans Video Meeting) at https://goo.gl/TjwUXC
Sponsors are the Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD) Community Outreach Core and Integrated Health Sciences Core.

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Workshop / Seminar Fri, 09 Nov 2018 12:07:37 -0500 2018-11-20T12:00:00-05:00 2018-11-20T13:00:00-05:00 School of Public Health Bldg I and Crossroads and Tower Center for Midlife Science Workshop / Seminar Flyer for Nov 20 Seminar+Webinar
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (November 20, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656577@events.umich.edu Event Begins: Tuesday, November 20, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-11-20T14:00:00-05:00 2018-11-20T16:00:00-05:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Roles of elusive translational GTPases (LepA and BipA) come to light (November 20, 2018 4:00pm) https://events.umich.edu/event/53787 53787-13461544@events.umich.edu Event Begins: Tuesday, November 20, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Protein synthesis relies on several translational GTPases (trGTPases), related proteins that couple the hydrolysis of GTP to specific molecular events on the ribosome. Most bacterial trGTPases, including IF2, EF-Tu, EF-G, and RF3, play well-known roles in translation. The cellular functions of LepA (also termed EF4) and BipA (also termed TypA), on the other hand, have remained enigmatic. I will discuss recent evidence that LepA and BipA function in biogenesis of the 30S and 50S subunit, respectively. These findings have important implications for ribosome biogenesis in bacteria.










Kurt Fredrick (The Ohio State University)

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Other Tue, 20 Nov 2018 18:15:28 -0500 2018-11-20T16:00:00-05:00 2018-11-20T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (November 21, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656621@events.umich.edu Event Begins: Wednesday, November 21, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-11-21T14:00:00-05:00 2018-11-21T16:00:00-05:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (November 26, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656667@events.umich.edu Event Begins: Monday, November 26, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-11-26T14:00:00-05:00 2018-11-26T16:00:00-05:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
RNA Innovation Seminar (November 26, 2018 3:00pm) https://events.umich.edu/event/55321 55321-13716057@events.umich.edu Event Begins: Monday, November 26, 2018 3:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Molly Kuo
MD, PhD candidate from the Antonellis Lab

and

Abby Lamb
PhD candidate from the Wittkopp Lab

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Lecture / Discussion Wed, 21 Nov 2018 08:30:29 -0500 2018-11-26T15:00:00-05:00 2018-11-26T16:00:00-05:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion logo
On the path to analytical utopia through the resolution of isomers by mass spectrometry (November 27, 2018 12:00pm) https://events.umich.edu/event/57538 57538-14211233@events.umich.edu Event Begins: Tuesday, November 27, 2018 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Advances in mass spectrometry over recent years have significantly improved the mass-resolving power of modern instrumentation and the speed with which high mass-accuracy data can be acquired. These advances have underpinned increased confidence in compound identification in complex mixtures and opened up entirely new means of data acquisition including the next generation of data-independent analytical workflows. While powerful, an inherent limitation in all these analytical approaches lies in the discrimination of isomers which, by definition, share the same elemental composition and thus the exact same mass. Conventional approaches to isomer discrimination have relied on chromatographic separations prior to mass analysis and tandem mass spectrometry however, this has proven a limited tool box for structurally similar isomers (e.g., regioisomers) and can significantly extend analysis times. Fortunately, exciting new developments in ion-mobility and ion-activation technologies are emerging to tackle the challenge of isomer-discrimination by mass spectrometry. This presentation will address the latest developments in these rapidly emerging technology areas in the context of lipidomic analysis with examples illustrating effective discrimination of regio- and even stereo-isomers.
















Stephen Blanksby (Queensland University of Technology)

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Other Tue, 27 Nov 2018 18:15:31 -0500 2018-11-27T12:00:00-05:00 2018-11-27T13:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (November 27, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656578@events.umich.edu Event Begins: Tuesday, November 27, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-11-27T14:00:00-05:00 2018-11-27T16:00:00-05:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Main-Group Metallomimetics: Strategies for Metal-Free Catalysis and Small-Molecule Activation (November 27, 2018 4:00pm) https://events.umich.edu/event/57147 57147-14121950@events.umich.edu Event Begins: Tuesday, November 27, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The importance of transition metals (TMs) in modern catalysis cannot be overstated. TM-based catalysts enable processes that are of tremendous human and economic importance; they have innumerable applications in many industrial sectors. However, the toxicity, price and natural scarcity of many elements that are used in TM catalysis fuels an interest for the development of metal-free catalysts based on the main-group elements. However, contrary to many catalytically-active TM-complexes, classical main-group compounds do not possess the combination of empty and filled orbitals that is crucial for the complex electronic processes involved in the elemental steps of catalytic cycles. The development of catalysts based on the p-block elements thus requires the design and application of unique strategies. In this talk, I will present two approaches for the metallomimetic application of boron compounds to small-molecule activation, to reduction processes, and to organic functionalization reactions. I will discuss systems that involve the combination of single and multiple active sites in order to mimic the electronic environment of TM complexes. Similarities and differences in the reactivity of main-group compounds and TM complexes will also be highlighted.






















Marc-Andre Legare, PhD (Universitat Wurzburg)

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Other Tue, 27 Nov 2018 18:15:31 -0500 2018-11-27T16:00:00-05:00 2018-11-27T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (November 28, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656622@events.umich.edu Event Begins: Wednesday, November 28, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-11-28T14:00:00-05:00 2018-11-28T16:00:00-05:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Spectroscopic characterization of unique iron and copper active sites in biology (November 29, 2018 4:00pm) https://events.umich.edu/event/57178 57178-14124207@events.umich.edu Event Begins: Thursday, November 29, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Iron and copper ions are ubiquitous in nature and serve a variety of important biological functions. My presentation will focus on the characterization of (1) the first biologically-relevant oxoiron(V) model complex and (2) a Cu/O2 intermediate in the mononuclear copper enzyme Formylglycine-Generating Enzyme (FGE). In both cases, we have been able to utilize spectroscopic insight to characterize novel, fleeting intermediates and to understand how they fit into proposed reaction mechanisms.

(1) Oxoiron(V) species are fleeting intermediates that are postulated to be involved in some of the most difficult oxidative transformations in biology. Using a biomimetic analog, we employed resonance Raman, electron paramagnetic resonance, and Mössbauer spectroscopies in conjunction with calibrated DFT computations to elucidate key structural and electronic properties. We were able to attribute its highly anisotropic hyperfine parameters and unusual spectroscopic features to an iron(V) complex with an axial oxo ligand. Our analysis defines spectroscopic parameters characteristic of perferryl intermediates in biology.

(2) Apart from its importance for sulfatase activity, FGE also serves as a powerful tool for protein engineering because of its ability to introduce aldehyde functional groups into recombinant proteins. Together with my collaborators, we have used high-energy X-ray techniques to spectroscopically define the unique copper active site in the absence and presence of its functional peptide substrate. Furthermore, we now have evidence for key intermediates along the O2-reaction pathway. With this crucial insight in hand, we have a more complete understanding of how FGE utilizes its unique mononuclear copper active site to activate O2, initiate reaction with substrate, and generate the Cα-formylglycine product.




Katlyn Meier, PhD. (Stanford University)

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Other Thu, 29 Nov 2018 18:15:35 -0500 2018-11-29T16:00:00-05:00 2018-11-29T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: Advanced metabolomics analysis by NMR with lessons for protein interactions (November 30, 2018 4:00pm) https://events.umich.edu/event/53440 53440-13381409@events.umich.edu Event Begins: Friday, November 30, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: The rapid, reliable and comprehensive identification and quantitation of a large number
of organic molecules in complex mixtures, such as metabolites in biological systems in the context of metabolomics, will be discussed using multidimensional NMR tools. They include curated databases of known metabolites, multidimensional spectral query for identification and quantitation, and rapid non-uniformly sampled 2D TOCSY collection and spectral reconstruction. Many of these developments are now available for automation and have been integrated into our COLMAR suite of web servers and databases (http://spin.ccic.ohio-state.edu/index.php/colmar).

Physical-chemical properties of metabolites can also be obtained by quantitatively analyzing their interaction propensities with synthetic nanoparticles. Such information, in turn, can be applied to understand and predict interaction profiles of intrinsically disordered proteins (IDPs) with nanoparticle surfaces.

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Workshop / Seminar Thu, 01 Nov 2018 08:55:42 -0400 2018-11-30T16:00:00-05:00 2018-11-30T17:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Rafael Bruschweiler
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (December 3, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656668@events.umich.edu Event Begins: Monday, December 3, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-12-03T14:00:00-05:00 2018-12-03T16:00:00-05:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
RNA Innovation Seminar (December 3, 2018 3:00pm) https://events.umich.edu/event/55327 55327-13716062@events.umich.edu Event Begins: Monday, December 3, 2018 3:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Huaqun Zhang, PhD
Postdoctoral research fellow from the Keane Lab
"Biophysical study of the RNA thermosensor prfA-UTR" 

and

Meredith Purchal, PhD candidate co-mentored in Markos Koutmos Lab and the Kristin Koutmou Lab
"Deciphering the Structure and Function of mRNA-Modifying Pseudouridine Synthases"

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Lecture / Discussion Tue, 27 Nov 2018 14:10:18 -0500 2018-12-03T15:00:00-05:00 2018-12-03T16:00:00-05:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion logo
Anders Hansen (December 3, 2018 4:00pm) https://events.umich.edu/event/57179 57179-14124208@events.umich.edu Event Begins: Monday, December 3, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Mammalian genes are regulated by enhancers, which can be hundreds of kilobases to megabases away from the gene whose expression they control by forming chromatin loops. Understanding mammalian gene regulation therefore requires understanding 3D genome organization. We have developed new chemical biology, computational and biophysical approaches to visualize the key proteins, CTCF and cohesin, that control chromatin looping at single-molecule resolution inside living cells. Similarly, we have developed approaches to directly visualize chromatin loops and to follow them dynamically as they form, function, and break inside living cells. We will discuss our results from these studies, which suggest that 3D genome organization and chromatin loops are likely much more dynamic than previously anticipated.




Anders Hansen, PhD (UC Berkeley)

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Other Mon, 03 Dec 2018 18:15:25 -0500 2018-12-03T16:00:00-05:00 2018-12-03T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Medical School Inside Story (December 3, 2018 5:00pm) https://events.umich.edu/event/53954 53954-13504383@events.umich.edu Event Begins: Monday, December 3, 2018 5:00pm
Location: University Hospitals
Organized By: Science Learning Center

Do you have questions about medical school admissions? Get your answers straight from the inside! U-M Medical School Admissions Director Carol Teener will demystify medical school applications, expectations, and reviews in her presentation. Please submit your questions via the form linked on the registration page, and Director Teener will answer as many as possible in the allotted hour.

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Workshop / Seminar Mon, 20 Aug 2018 13:15:16 -0400 2018-12-03T17:00:00-05:00 2018-12-03T18:00:00-05:00 University Hospitals Science Learning Center Workshop / Seminar
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (December 4, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656579@events.umich.edu Event Begins: Tuesday, December 4, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-12-04T14:00:00-05:00 2018-12-04T16:00:00-05:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (December 5, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656623@events.umich.edu Event Begins: Wednesday, December 5, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-12-05T14:00:00-05:00 2018-12-05T16:00:00-05:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
A Nobel Symposium. Learn about the 2018 Nobel Prizes (December 6, 2018 1:00pm) https://events.umich.edu/event/57643 57643-14246156@events.umich.edu Event Begins: Thursday, December 6, 2018 1:00pm
Location: Weiser Hall
Organized By: The Center for the Study of Complex Systems

Five U-M scholars discuss the work, impact, and personality of the Laureates of this year's five Nobel Prizes. (There will be snacks and coffee throughout the afternoon)

1PM PHYSICS - Ted Norris - Electrical Engineering & Computer Science will discuss the Physics prize shared by UM Emeritus Gérard Mourou and his then protegee Donna Strickland; and Arthur Ashkin. They are all recognized for their work on 'Tools made of light'.

1:45PM CHEMISTRY - James Bardwell - Molecular, Cellular & Developmental Biology, will discuss the Nobel Prize in Chemistry winners which include Frances H Arnold - for her work on the 'directed evolution of enzymes'; and George P. Smith and Sir Gregory P. Winter for 'the phage display of peptide and antibodies'.

2:30PM MEDICINE - Weiping Zou - Pathology, Immunology, Biology & Surgery, will discuss the prize being awarded to James P. Allison and Tasuku Honjo 'for their discovery of cancer therapy by inhibition of negative immune regulation'.

3:15PM ECONOMICS - Ellen Hughes-Cromwick - UM Energy Institute, will discuss the work of Prize recipients William D. Nordhaus and Paul M. Romer - for 'integrating climate change' (the former) and for 'integrating technological innovations' (the latter) 'into long-run macroeconomic analysis'.

4PM PEACE - Ragnhild Nordaas, Political Science - will talk about the work of Denis Mukwege and Nadia Murad, who both focus on 'courageously combating war crimes and seeking justice for victims'.

Each presentation will be 45 minutes (30 minutes presentation, with approx. 15 minutes questions and discussion).

Illustrations of Nobel Peace Prize Winners reprinted with permission of the illustration artist Niklas Elmehed. Copyright Nobel Media.

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Conference / Symposium Thu, 06 Dec 2018 08:36:37 -0500 2018-12-06T13:00:00-05:00 2018-12-06T16:45:00-05:00 Weiser Hall The Center for the Study of Complex Systems Conference / Symposium Nobel Peace Prize winners Denis Mukwege and Nadia Murad Ill. Niklas Elmehed - reprinted with permission
Studies on student learning in a new organic chemistry curriculum designed to deepen understanding of reactivity and chemistry principles (December 6, 2018 4:00pm) https://events.umich.edu/event/57556 57556-14213443@events.umich.edu Event Begins: Thursday, December 6, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Chemistry education research has revealed numerous challenges students face learning organic chemistry, including barriers learning chemistry’s language, interpreting, rationalizing, and predicting mechanistic processes and driving forces, and limitations in curricula connecting organic chemistry to broader contexts. In this presentation, I will more deeply describe these challenges, explain our efforts at addressing these challenges with a redesigned curriculum, and share our associated research findings.












Alison Flynn (University of Ottawa)

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Other Thu, 06 Dec 2018 18:15:27 -0500 2018-12-06T16:00:00-05:00 2018-12-06T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
“4D MAPPING OF SPATIOFUNCTIONAL ENZYME DROPLETS IN LIVING CELLS” (December 7, 2018 4:00pm) https://events.umich.edu/event/53441 53441-13381410@events.umich.edu Event Begins: Friday, December 7, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: The cytoplasmic, rate-determining enzymes in glucose metabolism are spatially organized into multienzyme assemblies in various sizes in human cells. They are proposed to shunt metabolic flux from glycolysis to anabolic biosynthetic pathways. However, how the formation of the enzyme assemblies and their sub-cellular locations in the cells are associated with their metabolic functions are largely unknown. In this work, we show that the enzyme assemblies in glucose metabolism are formed by liquid phase separation in a pathway specific manner. With 4D imaging using the home-built lattice light sheet microscope, we observe that the membraneless assemblies present liquid droplet properties. Moreover, we reveal that significant numbers of the enzyme assemblies are in proximity with mitochondria. We also monitor the reversible formation and spatial organization of the enzyme assembly upon the inhibition of mitochondrial metabolism. Our results shed light on how the enzyme assemblies are formed and positioned near cellular organelles to locally and efficiently orchestrate their metabolic functions. We envision that the presented “spatiofunctional” characteristics of the enzyme assemblies in glucose metabolism are an unprecedented starting point for mapping 4D functional metabolic network in live cells.

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Workshop / Seminar Fri, 16 Nov 2018 14:24:37 -0500 2018-12-07T16:00:00-05:00 2018-12-07T17:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Minjoung Kyoung
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (December 10, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656669@events.umich.edu Event Begins: Monday, December 10, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-12-10T14:00:00-05:00 2018-12-10T16:00:00-05:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Bringing Biochemistry into the Genomic Era (December 10, 2018 4:00pm) https://events.umich.edu/event/51012 51012-11941994@events.umich.edu Event Begins: Monday, December 10, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

High-throughput and quantitative biochemical approaches will be required to develop predictive models of cell function and regulation, and to understand systems as complex as enzymes. I will describe two such approaches and the insights attained to date. RNA-MaP developed by the Greenleaf lab at Stanford allows us to determine thermodynamic and kinetic rules for RNA binding by RNA binding proteins, and provides testable models for cellular RNA/protein interactions and additional biophysical and evolutionary insights. HT-MEK (High-throughput Mechanistic Enzyme Kinetics), a new microfluidics methodology developed by the Fordyce lab at Stanford, allows us to obtain quantitative kinetic and thermodynamic data for thousands of enzyme variants, in a small fraction of the time and at a minute fraction of the cost of traditional biochemical approaches. Our initial studies on an Alkaline Phosphatase superfamily member provide the first comprehensive functional landscape for an enzyme, delineating function throughout an enzyme scaffold. Studies on this and additional systems are needed to understand enzyme function, to reveal the action of drugs and allosteric effectors, and to develop rules to engineer new enzymes and pathways at will. Most generally, quantitative, high-throughput biochemical methodologies will usher in a post-genomic era in biology that is grounded in biochemical understanding and powered by quantitative physical models.





Daniel Herschlag (Stanford University)

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Other Mon, 10 Dec 2018 18:15:21 -0500 2018-12-10T16:00:00-05:00 2018-12-10T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Community-Academic Collaboration on Drinking Water Contamination by Fluorinated Compounds: in the Cape Fear (NC) River Basin (December 11, 2018 12:00pm) https://events.umich.edu/event/57880 57880-14366050@events.umich.edu Event Begins: Tuesday, December 11, 2018 12:00pm
Location: Off Campus Location
Organized By: Center for Midlife Science

Seminar and Webinar - Dr. Hoppin and Mr. Burdette will share their experiences and provide background information on the collaboration processes, the experience with blood testing and other biomonitoring as part of community engagement, and describe the GenX Exposure Study. Discussion topics include the importance of credibility in exposure research and lessons learned in the collaborative process.

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Workshop / Seminar Mon, 26 Nov 2018 13:04:29 -0500 2018-12-11T12:00:00-05:00 2018-12-11T13:00:00-05:00 Off Campus Location Center for Midlife Science Workshop / Seminar Flyer CEC+IHSC 12-11-2018
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (December 11, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656580@events.umich.edu Event Begins: Tuesday, December 11, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-12-11T14:00:00-05:00 2018-12-11T16:00:00-05:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Chemistry Under Extreme Pressures (December 11, 2018 4:00pm) https://events.umich.edu/event/57212 57212-14130895@events.umich.edu Event Begins: Tuesday, December 11, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Pressure is a fundamental thermodynamic variable that spans roughly 50 orders of magnitude throughout the universe, yet practically all of our chemical intuition is based upon results obtained near atmospheric conditions. At pressures on the order of millions of atmospheres—the kind found deep within our planet—elemental properties that we consider fundamental become categorically altered. For example, atomic volumes drop sharply, valence orbital energies can fall below those of core orbitals, and electronegativities drift from their tabulated ambient pressure values. Even at relatively modest pressures of ~10,000–100,000 atm, which are now readily accessible in the laboratory, these effects can lead to surprising new chemical bonding, structures, and properties, opening up a new frontier for chemical exploration. In this talk, I will show how we have harnessed pressure to: (i) exert thermodynamic control to synthesize novel binary bismuth intermetallic compounds that are impossible to synthesize using traditional methods; and (ii) determine chemically-pure structure–function correlations in jarosite, a magnetically-frustrated mineral.




James Walsh, PhD (Northwestern University)

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Other Tue, 11 Dec 2018 18:15:21 -0500 2018-12-11T16:00:00-05:00 2018-12-11T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (December 12, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656624@events.umich.edu Event Begins: Wednesday, December 12, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-12-12T14:00:00-05:00 2018-12-12T16:00:00-05:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Thesis Defense: “Modern Approaches to the Development of Energetic Materials” (December 14, 2018 10:00am) https://events.umich.edu/event/58326 58326-14463230@events.umich.edu Event Begins: Friday, December 14, 2018 10:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Rosalyn V. Kent (Advisor: Prof. Adam Matzger)

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Other Fri, 14 Dec 2018 18:15:20 -0500 2018-12-14T10:00:00-05:00 2018-12-14T11:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: “Computational Investigations of Organometallic Polymerization Reactions” (December 14, 2018 12:00pm) https://events.umich.edu/event/58325 58325-14463229@events.umich.edu Event Begins: Friday, December 14, 2018 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Andrew Vitek (Advisor: Prof. Paul Zimmerman)

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Other Fri, 14 Dec 2018 18:15:20 -0500 2018-12-14T12:00:00-05:00 2018-12-14T13:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: “The decision landscapes in living cells” (December 14, 2018 4:00pm) https://events.umich.edu/event/53442 53442-13381411@events.umich.edu Event Begins: Friday, December 14, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: Live cells routinely make decisions that are informed by external stimuli and endogenous noisy regulatory networks. At this point, we lack a coherent understanding of how these decisions are made, although we have developed mechanistic descriptions of various instances of decision making processes in specific systems. In this talk, using the recent experimental and modeling analyses of cell migration, proliferation and death conducted at our lab, I will suggest a methodology for quantitative understanding of cellular decision making. I will also demonstrate that this method has a powerful predictive power, with particular applications to therapeutic interventions in cancer and other complex diseases. This approach can be extended to other systems and can lay the foundations for a more integrative analysis of cell function.

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Workshop / Seminar Wed, 24 Oct 2018 14:21:39 -0400 2018-12-14T16:00:00-05:00 2018-12-14T17:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Andrew Levchenko
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (December 17, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656670@events.umich.edu Event Begins: Monday, December 17, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-12-17T14:00:00-05:00 2018-12-17T16:00:00-05:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
RNA Innovation Seminar (December 17, 2018 3:00pm) https://events.umich.edu/event/55324 55324-13716059@events.umich.edu Event Begins: Monday, December 17, 2018 3:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

1.) Monika Franco
PhD candidate from the Kristin Koutmou Lab
"Modification of mRNA can alter translation elongation, fidelity, and termination" 

2.) Gulzhan Raiymbek, PhD
Postdoc researcher from the Ragunathan Lab
"A non-enzymatic function associated with a putative histone demethylase regulates heterochromatin spreading and inheritance"

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Lecture / Discussion Wed, 28 Nov 2018 11:11:53 -0500 2018-12-17T15:00:00-05:00 2018-12-17T16:00:00-05:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion logo
Thesis Defense: “Development of New Strategies Towards Accessing Chiral Nitrogen Heterocycles” (December 17, 2018 4:00pm) https://events.umich.edu/event/58327 58327-14463231@events.umich.edu Event Begins: Monday, December 17, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Emilia J. Groso (Advisor: Prof. Corinna Schindler)

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Other Mon, 17 Dec 2018 18:15:25 -0500 2018-12-17T16:00:00-05:00 2018-12-17T17:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (December 18, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656581@events.umich.edu Event Begins: Tuesday, December 18, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-12-18T14:00:00-05:00 2018-12-18T16:00:00-05:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Recent Advances in Biomacromolecular NMR and High-Speed-AFM (December 18, 2018 3:00pm) https://events.umich.edu/event/58311 58311-14461161@events.umich.edu Event Begins: Tuesday, December 18, 2018 3:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




David Weliky(Michigan State University) , Yusuke Nishiyama(JEOL RESONANCE & RIKEN, Japan) , Martine Monette(Bruker NMR, Canada) , Takahiro Watanabe-Nakayama(Kanazawa University, Japan) , Jeffrey Brender(NIH)

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Other Tue, 18 Dec 2018 18:15:25 -0500 2018-12-18T15:00:00-05:00 2018-12-18T18:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
The effect of nucleosome conformation on histone tail binding: implications for chromatin signaling (December 18, 2018 4:00pm) https://events.umich.edu/event/55003 55003-13665197@events.umich.edu Event Begins: Tuesday, December 18, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Eukaryotic DNA exists in the cell nucleus via chromatin, which acts to both compact and regulate the genome. The basic subunit of chromatin is the nucleosome, which is comprised of a histone protein core, wrapped by ~147bp of DNA. The N-terminal regions of each of the histones protrude from the wrapped core and are referred to as the histone tails. Histone tails harbor a plethora of post-translational modifications (PTMs) that direct the function of chromatin regulators as they remodel chromatin during development and in response to external factors. Recognition of histone PTMs by these regulatory complexes is mediated through the action of reader sub-domains. The interaction of reader domains with modified histone tails has been extensively studied using peptide fragments of the tails. However, we have very little knowledge of how these domains associate with the full nucleosome. We are using NMR spectroscopy and complimentary orthogonal techniques to investigate this, and have found that the conformation of the histone tails in the context of the nucleosome has a dramatic effect on reader domain binding. As a model system, we are investigating the interaction of the BPTF PHD finger with its known cognate modification, methylated lysine 4 on histone H3 (H3K4me3). Here, we show that the conformation adopted by the histone H3 tails within the context of the nucleosome is inhibitory to binding of the BPTF PHD finger to H3K4me3, as compared to histone peptides. Using NMR spectroscopy and MD simulations, we find that the H3 tails interact robustly but dynamically with nucleosomal DNA, and demonstrate that this inhibits PHD finger association. Modifications and mutations of the H3 tail outside the binding region increase the accessibility to PHD finger binding, indicating that PTM crosstalk can regulate reader domain binding by altering the nucleosome conformation. Together, our results demonstrate that the nucleosome context has a dramatic impact on signaling events at the histone tails, and highlights the importance of studying histone binding in the context of the nucleosome.






Catherine Musselman (University of Iowa)

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Other Tue, 18 Dec 2018 18:15:25 -0500 2018-12-18T16:00:00-05:00 2018-12-18T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (December 19, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656625@events.umich.edu Event Begins: Wednesday, December 19, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-12-19T14:00:00-05:00 2018-12-19T16:00:00-05:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Genomics-guided discovery of peptide natural products in microbes and plants (January 8, 2019 2:00pm) https://events.umich.edu/event/58825 58825-14563542@events.umich.edu Event Begins: Tuesday, January 8, 2019 2:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry










Roland Kersten, PhD (Massachusetts Institute of Technology)

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Other Tue, 08 Jan 2019 18:15:29 -0500 2019-01-08T14:00:00-05:00 2019-01-08T15:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar: Genomics-guided discovery of peptide natural products in microbes and plants (January 8, 2019 2:00pm) https://events.umich.edu/event/58824 58824-14561473@events.umich.edu Event Begins: Tuesday, January 8, 2019 2:00pm
Location: Palmer Commons
Organized By: Life Sciences Institute (LSI)

One of the key steps in innovating new pharmaceutical solutions to human diseases is the discovery of new natural products. In the 20th century, natural product-based drug discovery was largely bioactivity-guided and was faced with limited source material and frequent rediscovery of bioactive lead structures. In the last two decades, whole genome sequencing revealed that fungal and microbial genomes harbor more biosynthetic pathways than characterized natural product structures. This untapped biosynthetic potential inspired gene-guided discovery of natural products – or ‘genome mining’ - by applied knowledge that certain biosynthetic genes in a genome are connected to certain natural product structures. Genome mining has led to the discovery of many new natural product classes from microbes and fungi, and synthetic biology approaches have subsequently enabled sustainable scaled production and diversification of these natural products for further drug development by source-independent expression of their biosynthetic genes in heterologous hosts.

Dr. Kersten will present how genome mining in the microbial and plant kingdoms can enable discovery of new natural product chemistry and underlying biochemistry for potential pharmacological applications. Specifically, he will discuss genome mining approaches utilizing mass spectrometry for the characterization of peptide natural products, including how they translate from compact microbial genomes to complex plant genomes and what awaits to be discovered in light of a rapidly growing resource of plant genomes in the near future.

Speaker bio:
Roland Kersten is a postdoctoral associate of Prof. Jing-Ke Weng’s lab at Whitehead Institute for Biomedical Research at MIT. He has a diploma in biochemistry from Free University of Berlin, Germany. He completed his PhD in 2013 from Scripps Institution of Oceanography, UC San Diego, under joint supervision of Prof. Pieter Dorrestein (Skaggs School of Pharmacy, UCSD) and Prof. Bradley Moore (Scripps Institution of Oceanography, UCSD) focusing on mass spectrometry-guided approaches for natural product discovery from microbes. In his postdoctoral research, Roland is developing gene-guided approaches for discovery and diversification of natural products from plants.

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Lecture / Discussion Wed, 02 Jan 2019 09:49:43 -0500 2019-01-08T14:00:00-05:00 2019-01-08T15:00:00-05:00 Palmer Commons Life Sciences Institute (LSI) Lecture / Discussion Dr. Roland Kersten
Dearomative Functionalization Strategies and Synthesis of Anticancer Natural Products (January 8, 2019 4:00pm) https://events.umich.edu/event/53788 53788-13461545@events.umich.edu Event Begins: Tuesday, January 8, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Small complex molecules are highly desired in all areas of chemistry, but they are also often difficult to access. Selective transformations of aromatic compounds could provide a more direct route to such desirable targets; however, the many challenges associated with dearomative functionalization have left these types of reactions widely underdeveloped. Our group has been developing new strategies that bridge the gap between dearomatization functionalization and alkene chemistry. In pursuit of this goal, we have developed dearomative functionalizations using small molecules – arenophiles – that enable reactions of isolated alkenes in aromatic substrates. Thus, well-established olefin reactions, such as dihydroxylation and reduction, can now be more directly applied to arenes. Additionally, arenophiles in combination with transition metal catalysis provide unique platform and enable the rapid access to a diverse range of products that are both challenging to synthesize via existing methods and complementary to those acquired through biological or chemical dearomative processes. Finally, using this methodology we have recently completed the synthesis of several complex anticancer natural products.










David Sarlah (University of Illinois)

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Other Tue, 08 Jan 2019 18:15:28 -0500 2019-01-08T16:00:00-05:00 2019-01-08T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: "Predicting RNA Structure with Physics and Sequence Comparison" (January 11, 2019 4:00pm) https://events.umich.edu/event/53443 53443-13381412@events.umich.edu Event Begins: Friday, January 11, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: RNA structure is hierarchical. The primary structure is the sequence of nucleotides. The secondary structure is the set of canonical (AU, GC, and GU) base pairs. The tertiary structure is the three dimensional position of the atoms and the additional intramolecular contacts that mediate the fold.

The Mathews lab develops methods to predict both RNA secondary structure and tertiary structure. In this talk, I will introduce nearest neighbor parameters for estimating folding stability of secondary structures and dynamic programming algorithms that predict secondary structure. I will then talk about new work in our lab to compare sequences to model conserved secondary structures. We developed a new method, called TurboFold, which is able to rapidly refine predicted secondary structures using sequence comparison and rapidly refine sequence alignments using structure information. I will also talk about new work to model RNA folding stability using molecular mechanics and 3D models. We used umbrella sampling to estimate the unfolding free energy change differences for three stem-loop structures, and we found good agreement with experiments.

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Workshop / Seminar Mon, 07 Jan 2019 16:52:23 -0500 2019-01-11T16:00:00-05:00 2019-01-11T17:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar David Mathews
Taking Inspiration From Bulk: Molecular Electrocatalysis and Magnetization Dynamics of Heterometallic Lanthanide – Transition Metal Complexes (January 16, 2019 4:00pm) https://events.umich.edu/event/52395 52395-12673362@events.umich.edu Event Begins: Wednesday, January 16, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The first part of the presentation will introduce our methodology towards improving molecular catalysts for energy relevant conversions. We strategically introduce redox-active and slightly acidic imidazolium moieties into the secondary coordination sphere of molecular CO2 reduction electrocatalysts. Results from systematic comparative studies will be presented that strongly suggest that mechanistic details of catalysis are altered for the new functionalized catalyst systems, resulting in improved catalytic metrics.

The second part of the seminar will discuss our strategies to study intramolecular interactions between transition metal (TM) and lanthanide (Ln) ions to generate novel spin systems that can display single-molecule magnet (SMM) properties. SMMs are very attractive candidates for the miniaturization of tunable information storage materials and quantum computing devices. Our work aims to generate heterometallic SMMs that feature either TM···Ln interactions or TM‑Ln bonding. I will present key results of our comprehensive structural and spectroscopic studies which have already led to the development of redox-switchable SMMs, new molecular platforms to facilitate strong magnetic coupling between Ln3+ ions, and hard SMM behavior."














Michael Nippe (Texas A&M University)

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Other Wed, 16 Jan 2019 18:15:33 -0500 2019-01-16T16:00:00-05:00 2019-01-16T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Visualizing Ultrafast Electron Dynamics at Catalytic Surfaces. (January 17, 2019 4:00pm) https://events.umich.edu/event/52760 52760-13021396@events.umich.edu Event Begins: Thursday, January 17, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


Directly observing electron dynamics at surfaces is required to reveal the material properties that determine efficiency during energy conversion catalysis. Toward this goal, we have developed a tabletop instrument for femtosecond X-ray spectroscopy of surfaces. This method combines the benefits of X-ray absorption, such as element, oxidation, and spin state specificity, with surface sensitivity and ultrafast time resolution, having a probe depth of only a few nm and time resolution faster than 100 fs. Using this technique, we study the electron dynamics in a number of catalytically relevant metal oxides. Specifically, Fe2O3 is an earth-abundant semiconductor with a band gap ideally suited for solar light harvesting, but its catalytic performance is low due to surface electron trapping. In these studies, we show that surface trapping occurs in less than 1 ps. Surprisingly this process is not sensitive to Fe2O3 surface morphology, indicating that electron trapping is not influenced by surface defects. Instead, ultrafast trapping occurs by the interactions of the free electrons with the lattice nuclei via a process known as small polaron formation. In contrast to Fe2O3, CuFeO2 is a closely related earth-abundant photocatalyst, which can reduce CO2 using sunlight. Specifically, we have recently shown that CuFeO2 is a selective catalyst for photo-electrochemical CO2 reduction to acetate. However, the role of electronic structure and charge carrier dynamics in this process has not been well understood. Using ultrafast X-ray spectroscopy, it is possible to track electrons and holes independently in the Fe 3d, Cu 3d, and O 2p states comprising the band structure of this photocatalyst. Results show that photocatalytic activity is related to ultrafast hole relaxation leading to spatial charge separation in the layered CuFeO2 lattice, which cannot occur in Fe2O3. This ability to elucidate site-specific charge carrier dynamics in real time provides important criteria for the rational design of catalysts for efficient solar energy harvesting based on their underlying photophysics.







L. Robert Baker (Ohio State University)

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Other Thu, 17 Jan 2019 18:15:30 -0500 2019-01-17T16:00:00-05:00 2019-01-17T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: "Architecture and Molecular Control of Cell-Cycle Entry and Exit Pathways: A Live-Cell Tale of Phosphorylation, Transcription and Degradation " (January 18, 2019 4:00pm) https://events.umich.edu/event/53444 53444-13381413@events.umich.edu Event Begins: Friday, January 18, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: Mammals must regulate the proliferation of stem, progenitor and differentiated cells to build, maintain, and repair tissues. Control of cell-cycle entry and exit has been conceptualized by the restriction point, a time when cells escape the need for mitogens to complete the cell cycle. Our single-cell microscopy studies discovered instead two parallel and partially redundant pathways to enter the cell cycle out of quiescence and three pathways out of mitosis. In lieu of a sharp restriction point, we find a progressive stabilization of both increasing CDK4/6 and CDK2 activities when tested by mitogen removal or stress, a stabilization that ends with an irreversible commitment point driven by multiple positive feedbacks. I will delineate core principles, molecular mechanisms and timing of this fundamental cell-fate commitment whose abnormal regulation is a main cause for cancer.

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Workshop / Seminar Fri, 11 Jan 2019 14:00:58 -0500 2019-01-18T16:00:00-05:00 2019-01-18T17:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Tobias Meyer
RNA Innovation Seminar, Theme: Microbiology (January 21, 2019 3:00pm) https://events.umich.edu/event/59712 59712-14780097@events.umich.edu Event Begins: Monday, January 21, 2019 3:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

1.) Adam Lauring, M.D., Ph.D.
Associate Professor, Departments of Internal Medicine and Microbiology and Immunology
Title of talk: “RNA virus mutation rates, new approaches to some old problems”
Keywords: Viral genetics, evolution, RNA dependent RNA polymerase, poliovirus, influenza virus

2.) Janet Price, Ph.D. candidate
from Matthew Chapman lab
Title of talk: “Seq-ing to Find Population Development During Biofilm Formation”

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Lecture / Discussion Tue, 15 Jan 2019 15:34:41 -0500 2019-01-21T15:00:00-05:00 2019-01-21T16:00:00-05:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion flyer
Next-generation tools for the synthesis of small molecules and biologics (January 22, 2019 4:00pm) https://events.umich.edu/event/52430 52430-12706750@events.umich.edu Event Begins: Tuesday, January 22, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry



The Walczak group studies methods to prepare and manipulate complex natural products and biologics such as (oligo)saccharides, peptides, and proteins. Our current interests are focused on the synthesis and chemical biology of mammalian and bacterial glycans that are known to engage in biological recognition and signaling events and show a promising therapeutic and diagnostic potential. While chemical synthesis has enabled a better understanding of the role of saccharides in homeostatic and developmental processes, key obstacles such as suboptimal selectivities in chemical glycosylation reactions await broadly applicable solutions. In this presentation, I will describe the development of metal-catalyzed methods that capitalize on stereoretentive reactions of anomeric nucleophiles suitable for the formation of C(sp3)-C and C(sp3)-heteroatom bonds. This seminar will also feature selected applications of the glycosyl cross-coupling method, mechanistic and computational studies that guided new reaction discovery, and integration with modern automation technologies.








Maciej Walczak (University of Colorado)

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Other Tue, 22 Jan 2019 18:15:30 -0500 2019-01-22T16:00:00-05:00 2019-01-22T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Beyond Carbon Neutral Seed Funding Final Outcomes Meeting (January 23, 2019 10:00am) https://events.umich.edu/event/60012 60012-14812550@events.umich.edu Event Begins: Wednesday, January 23, 2019 10:00am
Location: Michigan Memorial Phoenix Project
Organized By: University of Michigan Energy Institute

As the Energy Institute's Beyond Carbon Neutral Project merges into the Global CO2 Initiative, this mini-symposium will summarize the project's research outcomes and next steps. Please join us to hear exciting research outcomes from 14 interdisciplinary faculty teams.

Condensed agenda:
1. Introductions & Welcome by Anna Stefanopoulou & Bart Bartlett 10:00 AM
2. The Global CO2 Initiative at the University of Michigan Volker Sick 10:15 AM
3. Team Presentations of Seed Funding Results
Technical approaches 10:35-11:10 AM
Biological approaches 11:17-11:38 AM
Social science considerations 11:46 AM-12:00PM

About The Global CO2 Initiative:
The Global CO2 Initiative at the University of Michigan aims to reduce atmospheric CO2 levels by 4 gigatons per year by 2030. We fund and conduct research to transform CO2 into commercially successful products using technology assessment, technology development and commercialization. The Initiative will identify and assist with economics understanding and policy levers needed to speed progress of carbon-based product deployment, while gauging public perception of and interest in these products.
As global CO2 emissions continue to accelerate, a diverse set of solutions is critical to reduce, reverse and remove carbon dioxide emissions to prevent further atmospheric warming. Paired with the deployment of renewable energy and energy efficiency products, decarbonization technologies and methods can help achieve global climate goals in this century.

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Conference / Symposium Fri, 18 Jan 2019 10:53:56 -0500 2019-01-23T10:00:00-05:00 2019-01-23T12:00:00-05:00 Michigan Memorial Phoenix Project University of Michigan Energy Institute Conference / Symposium Steven Ragsdale BCN
TBA (January 24, 2019 4:00pm) https://events.umich.edu/event/52431 52431-12706751@events.umich.edu Event Begins: Thursday, January 24, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Regan Thomson (Northwestern University)

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Other Mon, 11 Jun 2018 12:15:23 -0400 2019-01-24T16:00:00-05:00 2019-01-24T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Mental Health Awareness Workshop (January 28, 2019 2:00pm) https://events.umich.edu/event/60143 60143-14840457@events.umich.edu Event Begins: Monday, January 28, 2019 2:00pm
Location: Palmer Commons
Organized By: STEM in Color

STEM in Color is pleased to invite you and your colleagues to our mental health awareness workshop: “How to Save a Life: Strategies for Addressing Mental Health Challenges in STEM and a Call for Cultural Change”. For this occasion, we have specifically partnered with the University of Michigan’s Counseling and Psychological Services (CAPS) to develop a workshop that will not only raise awareness surrounding the mental health challenges faced by our community, but one that will equip participants with research based strategies for promoting mental well-being through prevention, intervention, and coping mechanisms.

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Workshop / Seminar Mon, 21 Jan 2019 13:09:38 -0500 2019-01-28T14:00:00-05:00 2019-01-28T15:30:00-05:00 Palmer Commons STEM in Color Workshop / Seminar Mental Health Workshop
KLA-Tencor Corporate Info Session (January 29, 2019 6:00pm) https://events.umich.edu/event/60163 60163-14840480@events.umich.edu Event Begins: Tuesday, January 29, 2019 6:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Tau Beta Pi

It's our belief at KLA that innovators are true optimists. We take on complex technical challenges that often take years to solve. We work on the edges of deep science, exploring electron and photon optics, sensors, machine learning and data analytics. We help create the ideas and devices that transform the future.

Catering will be provided by Zingermann's

Majors: ChE, CE, CS, DS, EE, IOE, MSE, and ME
Degrees: Bachelor's, Master's, and Ph.D.'s
Positions: Full-time and Interns
Citizenship Requirement: U.S. Citizen or Permanent Resident
Collecting Resume's?: Yes

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Careers / Jobs Sun, 27 Jan 2019 14:39:03 -0500 2019-01-29T18:00:00-05:00 2019-01-29T19:00:00-05:00 Electrical Engineering and Computer Science Building Tau Beta Pi Careers / Jobs Company Icon
Bioethics Discussion: Gender (January 29, 2019 7:00pm) https://events.umich.edu/event/49430 49430-11453774@events.umich.edu Event Begins: Tuesday, January 29, 2019 7:00pm
Location: Lurie Biomedical Engineering
Organized By: The Bioethics Discussion Group

A roundtable discussion on who we are, who society sees, and who we want to be.

Readings to consider:
"Doing gender"
"For whom the burden tolls"
"Performative acts and gender constitution"
"The restroom revolution: unisex toilets and campus politics"

For more information and/or to receive a copy of the readings, please contact Barry Belmont at belmont@umich.edu or visit https://belmont.bme.umich.edu/bioethics-discussion-group/discussions/024-gender/.

Take a look at the blog: https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Sat, 15 Sep 2018 03:29:55 -0400 2019-01-29T19:00:00-05:00 2019-01-29T20:30:00-05:00 Lurie Biomedical Engineering The Bioethics Discussion Group Lecture / Discussion Gender
Department of Computational Medicine & Bioinformatics Weekly Seminar (January 30, 2019 4:00pm) https://events.umich.edu/event/60411 60411-14875271@events.umich.edu Event Begins: Wednesday, January 30, 2019 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Robert A. Coleman, PhD (Asst. Prof., Department of Anatomy and Structural Biology in the Gruss-Lipper Biophotonics Center at the Albert Einstein College of Medicine) will present the following abstract: Years of biochemical experiments have led to the identification of the eukaryotic transcription machinery and a static view of gene regulation. However, mechanisms controlling the dynamics of transcriptional regulation inside a crowded nucleus remains poorly understood. Recent advances in single molecule imaging have begun to shine light on these mechanisms, providing an unprecedented dynamic view of transcriptional regulation in live cells. We and others have found that transcription factors form dynamic hubs of activity in select nuclear compartments. I will discuss how formation of these hubs and recognition of genomic targets is regulated by interactions between transcription factors and the histone tails of chromatin. Transcription factors cycle on and off of their chromatin targets within these hubs on the order of seconds that likely reflect dynamic rates of chromatin remodeling, RNA Polymerase II convoy formation and transcriptional output of a gene. These findings are put into context describing how expression of the p21 cell cycle arrest gene is dynamically regulated by the tumor suppressor p53 protein and chromatin remodelers.

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Lecture / Discussion Fri, 25 Jan 2019 16:10:59 -0500 2019-01-30T16:00:00-05:00 2019-01-30T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
RNA Innovation Seminar, Theme: Medicinal Chemistry (February 4, 2019 3:00pm) https://events.umich.edu/event/59715 59715-14780096@events.umich.edu Event Begins: Monday, February 4, 2019 3:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

1.) Brittany Morgan, Ph.D.
from the Anna Mapp lab
Title of talk: “Rational Approaches to Design and Synthesize RNA-Biased Small Molecule Libraries”

2.) Andrew Robertson, Ph.D.
from the Sherman lab
Title of talk: “Towards the Treatment of HIV: Isolation and Structural Characterization of Natural Product Nef Inhibitors”

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Lecture / Discussion Tue, 15 Jan 2019 15:35:03 -0500 2019-02-04T15:00:00-05:00 2019-02-04T16:00:00-05:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion flyer
Chemistry: Much More than Just a Magic Trick (February 5, 2019 5:30pm) https://events.umich.edu/event/58972 58972-14628137@events.umich.edu Event Begins: Tuesday, February 5, 2019 5:30pm
Location: Off Campus Location
Organized By: Osher Lifelong Learning Institute (50+)

Do you ever wonder about the chemical differences between gin and rum? Or how about the science behind the baking of your favorite pastry or getting the perfect sear on your steak? And what about all the plastic we use in our daily lives? If so, your queries can all be answered through chemistry, and this course will focus on the magical chemical processes used in our everyday lives! So come join us to learn how to think like chemists as we discuss these topics and any others you might have in mind! As graduate students working towards our Ph.D.s in organic chemistry, we share a passion for science and look toward sharing our “magic tricks” with you.

Instructors Ellen Aguilera and Liz Meucci with lead these sessions for those 50 and above. The Study Group will meet on Tuesdays from 5:30 -7 p.m. and run from February 5 through March 12.

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Class / Instruction Thu, 27 Dec 2018 19:14:41 -0500 2019-02-05T17:30:00-05:00 2019-02-05T19:00:00-05:00 Off Campus Location Osher Lifelong Learning Institute (50+) Class / Instruction OLLI Study Group
State of the Union 2019 Debrief (February 6, 2019 1:00pm) https://events.umich.edu/event/60189 60189-14917072@events.umich.edu Event Begins: Wednesday, February 6, 2019 1:00pm
Location: Off Campus Location
Organized By: Engaging Scientists in Policy and Advocacy

Join us for lunch and discussion focused on the 2019 State of the Union, and reflections on this year in science policy. RSVP so we can order enough food: https://goo.gl/forms/wwJeexu2J4nsoRls1

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Meeting Wed, 30 Jan 2019 11:50:30 -0500 2019-02-06T13:00:00-05:00 2019-02-06T14:00:00-05:00 Off Campus Location Engaging Scientists in Policy and Advocacy Meeting SOTU 2019 flyer
Staying one step ahead: fighting unfavorable kinetics in biomass conversion and catalysis (February 6, 2019 4:00pm) https://events.umich.edu/event/56197 56197-13862520@events.umich.edu Event Begins: Wednesday, February 6, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

After atmospheric CO2, lignocellulosic biomass is the second-largest source of renewable carbon on our planet. This makes biomass a very attractive source of sustainable alternatives to fossil-derived chemicals. The production of various chemicals from biomass usually involves the depolymerization of biomass’s three constituent polymers: cellulose and hemicellulose, which are both polysaccharides; and lignin, which is a polymer of phenyl propanoid sub-units. These three types of complex molecules are broken down into their constituent monomers, which include sugars and phenyl propane derivatives. In turn, these low-molecular weight monomers can be catalytically upgraded to either direct or indirect substitutes for petrochemicals. In both depolymerization and catalytic upgrading, the biggest challenge is usually not achieving the desired reaction, but rather avoiding being outcompeted by other, detrimental reactions. Depolymerization reactions of the major biomass constituents – polysaccharides and lignin – are often outpaced by subsequent degradation reactions of sugars and lignin intermediates. In parallel, coking reactions and catalyst deactivation processes plague the upgrading of highly oxygenated and water-miscible biomass derivatives.

In this talk, I will present several solutions to these challenges that my laboratory has developed. I will show how we can use protection group chemistry, both during lignin extraction and polysaccharide depolymerization, to reversibly “trap” stabilized intermediate molecules, and facilitate their high-yield upgrading1,2. Notably, we can show that, under the right conditions, extracted lignin can be catalytically upgraded at high yields to as few as 1-2 major products3. I will also discuss how targeted surface modifications on heterogeneous catalysts can lead to dramatic changes in activity, stability and selectivity, even in the presence of highly oxygenated renewable streams4–6.

References:
1 L. Shuai, M. T. Amiri, Y. M. Questell-Santiago, F. Héroguel, Y. Li, H. Kim, R. Meilan, C. Chapple, J. Ralph and J. S. Luterbacher*, Science, 2016, 354, 329–333.
2 Y. M. Questell-Santiago, R. Zambrano-Varela, M. T. Amiri and J. S. Luterbacher*, Nat. Chem., 2018, 1222–1228.
3 W. Lan, M. T. Amiri, C. M. Hunston and J. S. Luterbacher*, Angew. Chem. Int. Ed., 2018, 57, 1356–1360.
4 F. Héroguel, B. P. Le Monnier, K. S. Brown, J. C. Siu and J. S. Luterbacher*, Appl. Catal. B Environ., 2017, 218, 643–649.
5 F. Héroguel, L. Silvioli, Y.-P. Du and J. S. Luterbacher*, J. Catal., 2018, 358, 50–61.
6 J. H. Yeap, F. Héroguel, R. L. Shahab, B. Rozmysłowicz, M. H. Studer and J. S. Luterbacher*, ACS Catal., 2018, 8, 10769–10773.











Jeremy Luterbacher (École Polytechnique Fédérale de Lausanne)

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Other Wed, 06 Feb 2019 18:15:58 -0500 2019-02-06T16:00:00-05:00 2019-02-06T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
TBP Drop-in Tutoring (February 6, 2019 5:30pm) https://events.umich.edu/event/60828 60828-14970709@events.umich.edu Event Begins: Wednesday, February 6, 2019 5:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Tau Beta Pi

Spend some time helping by fellow students with your classes! Classes include intro Physics, Math, Chemistry, and Engineering courses.

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Class / Instruction Tue, 05 Feb 2019 11:49:37 -0500 2019-02-06T17:30:00-05:00 2019-02-06T19:00:00-05:00 Electrical Engineering and Computer Science Building Tau Beta Pi Class / Instruction tbp-mi
U-M Biological Station Info Session + Faculty Panel (February 7, 2019 6:00pm) https://events.umich.edu/event/60182 60182-14846876@events.umich.edu Event Begins: Thursday, February 7, 2019 6:00pm
Location: Biological Sciences Building
Organized By: University of Michigan Biological Station

STUDENTS: Join us February 7, at 6 p.m. in 1010 Biological Sciences Building (BSB) to learn more about the Biological Station and hear from spring/summer professors about why their class IS THE BEST.

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Rally / Mass Meeting Thu, 24 Jan 2019 09:42:16 -0500 2019-02-07T18:00:00-05:00 2019-02-07T19:00:00-05:00 Biological Sciences Building University of Michigan Biological Station Rally / Mass Meeting Sunset on Douglas Lake.