Happening @ Michigan https://events.umich.edu/list/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (December 10, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656669@events.umich.edu Event Begins: Monday, December 10, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-12-10T14:00:00-05:00 2018-12-10T16:00:00-05:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Bringing Biochemistry into the Genomic Era (December 10, 2018 4:00pm) https://events.umich.edu/event/51012 51012-11941994@events.umich.edu Event Begins: Monday, December 10, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

High-throughput and quantitative biochemical approaches will be required to develop predictive models of cell function and regulation, and to understand systems as complex as enzymes. I will describe two such approaches and the insights attained to date. RNA-MaP developed by the Greenleaf lab at Stanford allows us to determine thermodynamic and kinetic rules for RNA binding by RNA binding proteins, and provides testable models for cellular RNA/protein interactions and additional biophysical and evolutionary insights. HT-MEK (High-throughput Mechanistic Enzyme Kinetics), a new microfluidics methodology developed by the Fordyce lab at Stanford, allows us to obtain quantitative kinetic and thermodynamic data for thousands of enzyme variants, in a small fraction of the time and at a minute fraction of the cost of traditional biochemical approaches. Our initial studies on an Alkaline Phosphatase superfamily member provide the first comprehensive functional landscape for an enzyme, delineating function throughout an enzyme scaffold. Studies on this and additional systems are needed to understand enzyme function, to reveal the action of drugs and allosteric effectors, and to develop rules to engineer new enzymes and pathways at will. Most generally, quantitative, high-throughput biochemical methodologies will usher in a post-genomic era in biology that is grounded in biochemical understanding and powered by quantitative physical models.





Daniel Herschlag (Stanford University)

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Other Mon, 10 Dec 2018 18:15:21 -0500 2018-12-10T16:00:00-05:00 2018-12-10T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Community-Academic Collaboration on Drinking Water Contamination by Fluorinated Compounds: in the Cape Fear (NC) River Basin (December 11, 2018 12:00pm) https://events.umich.edu/event/57880 57880-14366050@events.umich.edu Event Begins: Tuesday, December 11, 2018 12:00pm
Location: Off Campus Location
Organized By: Center for Midlife Science

Seminar and Webinar - Dr. Hoppin and Mr. Burdette will share their experiences and provide background information on the collaboration processes, the experience with blood testing and other biomonitoring as part of community engagement, and describe the GenX Exposure Study. Discussion topics include the importance of credibility in exposure research and lessons learned in the collaborative process.

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Workshop / Seminar Mon, 26 Nov 2018 13:04:29 -0500 2018-12-11T12:00:00-05:00 2018-12-11T13:00:00-05:00 Off Campus Location Center for Midlife Science Workshop / Seminar Flyer CEC+IHSC 12-11-2018
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (December 11, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656580@events.umich.edu Event Begins: Tuesday, December 11, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-12-11T14:00:00-05:00 2018-12-11T16:00:00-05:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Chemistry Under Extreme Pressures (December 11, 2018 4:00pm) https://events.umich.edu/event/57212 57212-14130895@events.umich.edu Event Begins: Tuesday, December 11, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Pressure is a fundamental thermodynamic variable that spans roughly 50 orders of magnitude throughout the universe, yet practically all of our chemical intuition is based upon results obtained near atmospheric conditions. At pressures on the order of millions of atmospheres—the kind found deep within our planet—elemental properties that we consider fundamental become categorically altered. For example, atomic volumes drop sharply, valence orbital energies can fall below those of core orbitals, and electronegativities drift from their tabulated ambient pressure values. Even at relatively modest pressures of ~10,000–100,000 atm, which are now readily accessible in the laboratory, these effects can lead to surprising new chemical bonding, structures, and properties, opening up a new frontier for chemical exploration. In this talk, I will show how we have harnessed pressure to: (i) exert thermodynamic control to synthesize novel binary bismuth intermetallic compounds that are impossible to synthesize using traditional methods; and (ii) determine chemically-pure structure–function correlations in jarosite, a magnetically-frustrated mineral.




James Walsh, PhD (Northwestern University)

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Other Tue, 11 Dec 2018 18:15:21 -0500 2018-12-11T16:00:00-05:00 2018-12-11T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (December 12, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656624@events.umich.edu Event Begins: Wednesday, December 12, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-12-12T14:00:00-05:00 2018-12-12T16:00:00-05:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Thesis Defense: “Modern Approaches to the Development of Energetic Materials” (December 14, 2018 10:00am) https://events.umich.edu/event/58326 58326-14463230@events.umich.edu Event Begins: Friday, December 14, 2018 10:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Rosalyn V. Kent (Advisor: Prof. Adam Matzger)

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Other Fri, 14 Dec 2018 18:15:20 -0500 2018-12-14T10:00:00-05:00 2018-12-14T11:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: “Computational Investigations of Organometallic Polymerization Reactions” (December 14, 2018 12:00pm) https://events.umich.edu/event/58325 58325-14463229@events.umich.edu Event Begins: Friday, December 14, 2018 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Andrew Vitek (Advisor: Prof. Paul Zimmerman)

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Other Fri, 14 Dec 2018 18:15:20 -0500 2018-12-14T12:00:00-05:00 2018-12-14T13:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: “The decision landscapes in living cells” (December 14, 2018 4:00pm) https://events.umich.edu/event/53442 53442-13381411@events.umich.edu Event Begins: Friday, December 14, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: Live cells routinely make decisions that are informed by external stimuli and endogenous noisy regulatory networks. At this point, we lack a coherent understanding of how these decisions are made, although we have developed mechanistic descriptions of various instances of decision making processes in specific systems. In this talk, using the recent experimental and modeling analyses of cell migration, proliferation and death conducted at our lab, I will suggest a methodology for quantitative understanding of cellular decision making. I will also demonstrate that this method has a powerful predictive power, with particular applications to therapeutic interventions in cancer and other complex diseases. This approach can be extended to other systems and can lay the foundations for a more integrative analysis of cell function.

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Workshop / Seminar Wed, 24 Oct 2018 14:21:39 -0400 2018-12-14T16:00:00-05:00 2018-12-14T17:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Andrew Levchenko
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (December 17, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656670@events.umich.edu Event Begins: Monday, December 17, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-12-17T14:00:00-05:00 2018-12-17T16:00:00-05:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
RNA Innovation Seminar (December 17, 2018 3:00pm) https://events.umich.edu/event/55324 55324-13716059@events.umich.edu Event Begins: Monday, December 17, 2018 3:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

1.) Monika Franco
PhD candidate from the Kristin Koutmou Lab
"Modification of mRNA can alter translation elongation, fidelity, and termination" 

2.) Gulzhan Raiymbek, PhD
Postdoc researcher from the Ragunathan Lab
"A non-enzymatic function associated with a putative histone demethylase regulates heterochromatin spreading and inheritance"

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Lecture / Discussion Wed, 28 Nov 2018 11:11:53 -0500 2018-12-17T15:00:00-05:00 2018-12-17T16:00:00-05:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion logo
Thesis Defense: “Development of New Strategies Towards Accessing Chiral Nitrogen Heterocycles” (December 17, 2018 4:00pm) https://events.umich.edu/event/58327 58327-14463231@events.umich.edu Event Begins: Monday, December 17, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Emilia J. Groso (Advisor: Prof. Corinna Schindler)

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Other Mon, 17 Dec 2018 18:15:25 -0500 2018-12-17T16:00:00-05:00 2018-12-17T17:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (December 18, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656581@events.umich.edu Event Begins: Tuesday, December 18, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-12-18T14:00:00-05:00 2018-12-18T16:00:00-05:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Recent Advances in Biomacromolecular NMR and High-Speed-AFM (December 18, 2018 3:00pm) https://events.umich.edu/event/58311 58311-14461161@events.umich.edu Event Begins: Tuesday, December 18, 2018 3:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




David Weliky(Michigan State University) , Yusuke Nishiyama(JEOL RESONANCE & RIKEN, Japan) , Martine Monette(Bruker NMR, Canada) , Takahiro Watanabe-Nakayama(Kanazawa University, Japan) , Jeffrey Brender(NIH)

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Other Tue, 18 Dec 2018 18:15:25 -0500 2018-12-18T15:00:00-05:00 2018-12-18T18:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
The effect of nucleosome conformation on histone tail binding: implications for chromatin signaling (December 18, 2018 4:00pm) https://events.umich.edu/event/55003 55003-13665197@events.umich.edu Event Begins: Tuesday, December 18, 2018 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Eukaryotic DNA exists in the cell nucleus via chromatin, which acts to both compact and regulate the genome. The basic subunit of chromatin is the nucleosome, which is comprised of a histone protein core, wrapped by ~147bp of DNA. The N-terminal regions of each of the histones protrude from the wrapped core and are referred to as the histone tails. Histone tails harbor a plethora of post-translational modifications (PTMs) that direct the function of chromatin regulators as they remodel chromatin during development and in response to external factors. Recognition of histone PTMs by these regulatory complexes is mediated through the action of reader sub-domains. The interaction of reader domains with modified histone tails has been extensively studied using peptide fragments of the tails. However, we have very little knowledge of how these domains associate with the full nucleosome. We are using NMR spectroscopy and complimentary orthogonal techniques to investigate this, and have found that the conformation of the histone tails in the context of the nucleosome has a dramatic effect on reader domain binding. As a model system, we are investigating the interaction of the BPTF PHD finger with its known cognate modification, methylated lysine 4 on histone H3 (H3K4me3). Here, we show that the conformation adopted by the histone H3 tails within the context of the nucleosome is inhibitory to binding of the BPTF PHD finger to H3K4me3, as compared to histone peptides. Using NMR spectroscopy and MD simulations, we find that the H3 tails interact robustly but dynamically with nucleosomal DNA, and demonstrate that this inhibits PHD finger association. Modifications and mutations of the H3 tail outside the binding region increase the accessibility to PHD finger binding, indicating that PTM crosstalk can regulate reader domain binding by altering the nucleosome conformation. Together, our results demonstrate that the nucleosome context has a dramatic impact on signaling events at the histone tails, and highlights the importance of studying histone binding in the context of the nucleosome.






Catherine Musselman (University of Iowa)

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Other Tue, 18 Dec 2018 18:15:25 -0500 2018-12-18T16:00:00-05:00 2018-12-18T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Introductory Techniques Seminars presented by The Michigan Center for Materials Characterization (December 19, 2018 2:00pm) https://events.umich.edu/event/50185 50185-11656625@events.umich.edu Event Begins: Wednesday, December 19, 2018 2:00pm
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Materials Characterization

This continuing series of seminars is designed to introduce potential users of our center to a range of the techniques that are employed with our instruments. For more detail on the instrumentation in the center and the topics covered by our seminars, visit http://mc2.engin.umich.edu. Questions may on the seminar series may be directed to John Mansfield (jfmjfm@umich.edu)

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Workshop / Seminar Wed, 30 May 2018 08:08:33 -0400 2018-12-19T14:00:00-05:00 2018-12-19T16:00:00-05:00 North Campus Research Complex Building 18 Michigan Center for Materials Characterization Workshop / Seminar Instruments & Techniques in (MC)2
Genomics-guided discovery of peptide natural products in microbes and plants (January 8, 2019 2:00pm) https://events.umich.edu/event/58825 58825-14563542@events.umich.edu Event Begins: Tuesday, January 8, 2019 2:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry










Roland Kersten, PhD (Massachusetts Institute of Technology)

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Other Tue, 08 Jan 2019 18:15:29 -0500 2019-01-08T14:00:00-05:00 2019-01-08T15:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar: Genomics-guided discovery of peptide natural products in microbes and plants (January 8, 2019 2:00pm) https://events.umich.edu/event/58824 58824-14561473@events.umich.edu Event Begins: Tuesday, January 8, 2019 2:00pm
Location: Palmer Commons
Organized By: Life Sciences Institute (LSI)

One of the key steps in innovating new pharmaceutical solutions to human diseases is the discovery of new natural products. In the 20th century, natural product-based drug discovery was largely bioactivity-guided and was faced with limited source material and frequent rediscovery of bioactive lead structures. In the last two decades, whole genome sequencing revealed that fungal and microbial genomes harbor more biosynthetic pathways than characterized natural product structures. This untapped biosynthetic potential inspired gene-guided discovery of natural products – or ‘genome mining’ - by applied knowledge that certain biosynthetic genes in a genome are connected to certain natural product structures. Genome mining has led to the discovery of many new natural product classes from microbes and fungi, and synthetic biology approaches have subsequently enabled sustainable scaled production and diversification of these natural products for further drug development by source-independent expression of their biosynthetic genes in heterologous hosts.

Dr. Kersten will present how genome mining in the microbial and plant kingdoms can enable discovery of new natural product chemistry and underlying biochemistry for potential pharmacological applications. Specifically, he will discuss genome mining approaches utilizing mass spectrometry for the characterization of peptide natural products, including how they translate from compact microbial genomes to complex plant genomes and what awaits to be discovered in light of a rapidly growing resource of plant genomes in the near future.

Speaker bio:
Roland Kersten is a postdoctoral associate of Prof. Jing-Ke Weng’s lab at Whitehead Institute for Biomedical Research at MIT. He has a diploma in biochemistry from Free University of Berlin, Germany. He completed his PhD in 2013 from Scripps Institution of Oceanography, UC San Diego, under joint supervision of Prof. Pieter Dorrestein (Skaggs School of Pharmacy, UCSD) and Prof. Bradley Moore (Scripps Institution of Oceanography, UCSD) focusing on mass spectrometry-guided approaches for natural product discovery from microbes. In his postdoctoral research, Roland is developing gene-guided approaches for discovery and diversification of natural products from plants.

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Lecture / Discussion Wed, 02 Jan 2019 09:49:43 -0500 2019-01-08T14:00:00-05:00 2019-01-08T15:00:00-05:00 Palmer Commons Life Sciences Institute (LSI) Lecture / Discussion Dr. Roland Kersten
Dearomative Functionalization Strategies and Synthesis of Anticancer Natural Products (January 8, 2019 4:00pm) https://events.umich.edu/event/53788 53788-13461545@events.umich.edu Event Begins: Tuesday, January 8, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Small complex molecules are highly desired in all areas of chemistry, but they are also often difficult to access. Selective transformations of aromatic compounds could provide a more direct route to such desirable targets; however, the many challenges associated with dearomative functionalization have left these types of reactions widely underdeveloped. Our group has been developing new strategies that bridge the gap between dearomatization functionalization and alkene chemistry. In pursuit of this goal, we have developed dearomative functionalizations using small molecules – arenophiles – that enable reactions of isolated alkenes in aromatic substrates. Thus, well-established olefin reactions, such as dihydroxylation and reduction, can now be more directly applied to arenes. Additionally, arenophiles in combination with transition metal catalysis provide unique platform and enable the rapid access to a diverse range of products that are both challenging to synthesize via existing methods and complementary to those acquired through biological or chemical dearomative processes. Finally, using this methodology we have recently completed the synthesis of several complex anticancer natural products.










David Sarlah (University of Illinois)

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Other Tue, 08 Jan 2019 18:15:28 -0500 2019-01-08T16:00:00-05:00 2019-01-08T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: "Predicting RNA Structure with Physics and Sequence Comparison" (January 11, 2019 4:00pm) https://events.umich.edu/event/53443 53443-13381412@events.umich.edu Event Begins: Friday, January 11, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: RNA structure is hierarchical. The primary structure is the sequence of nucleotides. The secondary structure is the set of canonical (AU, GC, and GU) base pairs. The tertiary structure is the three dimensional position of the atoms and the additional intramolecular contacts that mediate the fold.

The Mathews lab develops methods to predict both RNA secondary structure and tertiary structure. In this talk, I will introduce nearest neighbor parameters for estimating folding stability of secondary structures and dynamic programming algorithms that predict secondary structure. I will then talk about new work in our lab to compare sequences to model conserved secondary structures. We developed a new method, called TurboFold, which is able to rapidly refine predicted secondary structures using sequence comparison and rapidly refine sequence alignments using structure information. I will also talk about new work to model RNA folding stability using molecular mechanics and 3D models. We used umbrella sampling to estimate the unfolding free energy change differences for three stem-loop structures, and we found good agreement with experiments.

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Workshop / Seminar Mon, 07 Jan 2019 16:52:23 -0500 2019-01-11T16:00:00-05:00 2019-01-11T17:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar David Mathews
Taking Inspiration From Bulk: Molecular Electrocatalysis and Magnetization Dynamics of Heterometallic Lanthanide – Transition Metal Complexes (January 16, 2019 4:00pm) https://events.umich.edu/event/52395 52395-12673362@events.umich.edu Event Begins: Wednesday, January 16, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The first part of the presentation will introduce our methodology towards improving molecular catalysts for energy relevant conversions. We strategically introduce redox-active and slightly acidic imidazolium moieties into the secondary coordination sphere of molecular CO2 reduction electrocatalysts. Results from systematic comparative studies will be presented that strongly suggest that mechanistic details of catalysis are altered for the new functionalized catalyst systems, resulting in improved catalytic metrics.

The second part of the seminar will discuss our strategies to study intramolecular interactions between transition metal (TM) and lanthanide (Ln) ions to generate novel spin systems that can display single-molecule magnet (SMM) properties. SMMs are very attractive candidates for the miniaturization of tunable information storage materials and quantum computing devices. Our work aims to generate heterometallic SMMs that feature either TM···Ln interactions or TM‑Ln bonding. I will present key results of our comprehensive structural and spectroscopic studies which have already led to the development of redox-switchable SMMs, new molecular platforms to facilitate strong magnetic coupling between Ln3+ ions, and hard SMM behavior."














Michael Nippe (Texas A&M University)

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Other Wed, 16 Jan 2019 18:15:33 -0500 2019-01-16T16:00:00-05:00 2019-01-16T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Visualizing Ultrafast Electron Dynamics at Catalytic Surfaces. (January 17, 2019 4:00pm) https://events.umich.edu/event/52760 52760-13021396@events.umich.edu Event Begins: Thursday, January 17, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


Directly observing electron dynamics at surfaces is required to reveal the material properties that determine efficiency during energy conversion catalysis. Toward this goal, we have developed a tabletop instrument for femtosecond X-ray spectroscopy of surfaces. This method combines the benefits of X-ray absorption, such as element, oxidation, and spin state specificity, with surface sensitivity and ultrafast time resolution, having a probe depth of only a few nm and time resolution faster than 100 fs. Using this technique, we study the electron dynamics in a number of catalytically relevant metal oxides. Specifically, Fe2O3 is an earth-abundant semiconductor with a band gap ideally suited for solar light harvesting, but its catalytic performance is low due to surface electron trapping. In these studies, we show that surface trapping occurs in less than 1 ps. Surprisingly this process is not sensitive to Fe2O3 surface morphology, indicating that electron trapping is not influenced by surface defects. Instead, ultrafast trapping occurs by the interactions of the free electrons with the lattice nuclei via a process known as small polaron formation. In contrast to Fe2O3, CuFeO2 is a closely related earth-abundant photocatalyst, which can reduce CO2 using sunlight. Specifically, we have recently shown that CuFeO2 is a selective catalyst for photo-electrochemical CO2 reduction to acetate. However, the role of electronic structure and charge carrier dynamics in this process has not been well understood. Using ultrafast X-ray spectroscopy, it is possible to track electrons and holes independently in the Fe 3d, Cu 3d, and O 2p states comprising the band structure of this photocatalyst. Results show that photocatalytic activity is related to ultrafast hole relaxation leading to spatial charge separation in the layered CuFeO2 lattice, which cannot occur in Fe2O3. This ability to elucidate site-specific charge carrier dynamics in real time provides important criteria for the rational design of catalysts for efficient solar energy harvesting based on their underlying photophysics.







L. Robert Baker (Ohio State University)

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Other Thu, 17 Jan 2019 18:15:30 -0500 2019-01-17T16:00:00-05:00 2019-01-17T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: "Architecture and Molecular Control of Cell-Cycle Entry and Exit Pathways: A Live-Cell Tale of Phosphorylation, Transcription and Degradation " (January 18, 2019 4:00pm) https://events.umich.edu/event/53444 53444-13381413@events.umich.edu Event Begins: Friday, January 18, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: Mammals must regulate the proliferation of stem, progenitor and differentiated cells to build, maintain, and repair tissues. Control of cell-cycle entry and exit has been conceptualized by the restriction point, a time when cells escape the need for mitogens to complete the cell cycle. Our single-cell microscopy studies discovered instead two parallel and partially redundant pathways to enter the cell cycle out of quiescence and three pathways out of mitosis. In lieu of a sharp restriction point, we find a progressive stabilization of both increasing CDK4/6 and CDK2 activities when tested by mitogen removal or stress, a stabilization that ends with an irreversible commitment point driven by multiple positive feedbacks. I will delineate core principles, molecular mechanisms and timing of this fundamental cell-fate commitment whose abnormal regulation is a main cause for cancer.

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Workshop / Seminar Fri, 11 Jan 2019 14:00:58 -0500 2019-01-18T16:00:00-05:00 2019-01-18T17:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Tobias Meyer
RNA Innovation Seminar, Theme: Microbiology (January 21, 2019 3:00pm) https://events.umich.edu/event/59712 59712-14780097@events.umich.edu Event Begins: Monday, January 21, 2019 3:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

1.) Adam Lauring, M.D., Ph.D.
Associate Professor, Departments of Internal Medicine and Microbiology and Immunology
Title of talk: “RNA virus mutation rates, new approaches to some old problems”
Keywords: Viral genetics, evolution, RNA dependent RNA polymerase, poliovirus, influenza virus

2.) Janet Price, Ph.D. candidate
from Matthew Chapman lab
Title of talk: “Seq-ing to Find Population Development During Biofilm Formation”

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Lecture / Discussion Tue, 15 Jan 2019 15:34:41 -0500 2019-01-21T15:00:00-05:00 2019-01-21T16:00:00-05:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion flyer
Next-generation tools for the synthesis of small molecules and biologics (January 22, 2019 4:00pm) https://events.umich.edu/event/52430 52430-12706750@events.umich.edu Event Begins: Tuesday, January 22, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry



The Walczak group studies methods to prepare and manipulate complex natural products and biologics such as (oligo)saccharides, peptides, and proteins. Our current interests are focused on the synthesis and chemical biology of mammalian and bacterial glycans that are known to engage in biological recognition and signaling events and show a promising therapeutic and diagnostic potential. While chemical synthesis has enabled a better understanding of the role of saccharides in homeostatic and developmental processes, key obstacles such as suboptimal selectivities in chemical glycosylation reactions await broadly applicable solutions. In this presentation, I will describe the development of metal-catalyzed methods that capitalize on stereoretentive reactions of anomeric nucleophiles suitable for the formation of C(sp3)-C and C(sp3)-heteroatom bonds. This seminar will also feature selected applications of the glycosyl cross-coupling method, mechanistic and computational studies that guided new reaction discovery, and integration with modern automation technologies.








Maciej Walczak (University of Colorado)

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Other Tue, 22 Jan 2019 18:15:30 -0500 2019-01-22T16:00:00-05:00 2019-01-22T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Beyond Carbon Neutral Seed Funding Final Outcomes Meeting (January 23, 2019 10:00am) https://events.umich.edu/event/60012 60012-14812550@events.umich.edu Event Begins: Wednesday, January 23, 2019 10:00am
Location: Michigan Memorial Phoenix Project
Organized By: University of Michigan Energy Institute

As the Energy Institute's Beyond Carbon Neutral Project merges into the Global CO2 Initiative, this mini-symposium will summarize the project's research outcomes and next steps. Please join us to hear exciting research outcomes from 14 interdisciplinary faculty teams.

Condensed agenda:
1. Introductions & Welcome by Anna Stefanopoulou & Bart Bartlett 10:00 AM
2. The Global CO2 Initiative at the University of Michigan Volker Sick 10:15 AM
3. Team Presentations of Seed Funding Results
Technical approaches 10:35-11:10 AM
Biological approaches 11:17-11:38 AM
Social science considerations 11:46 AM-12:00PM

About The Global CO2 Initiative:
The Global CO2 Initiative at the University of Michigan aims to reduce atmospheric CO2 levels by 4 gigatons per year by 2030. We fund and conduct research to transform CO2 into commercially successful products using technology assessment, technology development and commercialization. The Initiative will identify and assist with economics understanding and policy levers needed to speed progress of carbon-based product deployment, while gauging public perception of and interest in these products.
As global CO2 emissions continue to accelerate, a diverse set of solutions is critical to reduce, reverse and remove carbon dioxide emissions to prevent further atmospheric warming. Paired with the deployment of renewable energy and energy efficiency products, decarbonization technologies and methods can help achieve global climate goals in this century.

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Conference / Symposium Fri, 18 Jan 2019 10:53:56 -0500 2019-01-23T10:00:00-05:00 2019-01-23T12:00:00-05:00 Michigan Memorial Phoenix Project University of Michigan Energy Institute Conference / Symposium Steven Ragsdale BCN
TBA (January 24, 2019 4:00pm) https://events.umich.edu/event/52431 52431-12706751@events.umich.edu Event Begins: Thursday, January 24, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Regan Thomson (Northwestern University)

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Other Mon, 11 Jun 2018 12:15:23 -0400 2019-01-24T16:00:00-05:00 2019-01-24T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Mental Health Awareness Workshop (January 28, 2019 2:00pm) https://events.umich.edu/event/60143 60143-14840457@events.umich.edu Event Begins: Monday, January 28, 2019 2:00pm
Location: Palmer Commons
Organized By: STEM in Color

STEM in Color is pleased to invite you and your colleagues to our mental health awareness workshop: “How to Save a Life: Strategies for Addressing Mental Health Challenges in STEM and a Call for Cultural Change”. For this occasion, we have specifically partnered with the University of Michigan’s Counseling and Psychological Services (CAPS) to develop a workshop that will not only raise awareness surrounding the mental health challenges faced by our community, but one that will equip participants with research based strategies for promoting mental well-being through prevention, intervention, and coping mechanisms.

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Workshop / Seminar Mon, 21 Jan 2019 13:09:38 -0500 2019-01-28T14:00:00-05:00 2019-01-28T15:30:00-05:00 Palmer Commons STEM in Color Workshop / Seminar Mental Health Workshop
KLA-Tencor Corporate Info Session (January 29, 2019 6:00pm) https://events.umich.edu/event/60163 60163-14840480@events.umich.edu Event Begins: Tuesday, January 29, 2019 6:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Tau Beta Pi

It's our belief at KLA that innovators are true optimists. We take on complex technical challenges that often take years to solve. We work on the edges of deep science, exploring electron and photon optics, sensors, machine learning and data analytics. We help create the ideas and devices that transform the future.

Catering will be provided by Zingermann's

Majors: ChE, CE, CS, DS, EE, IOE, MSE, and ME
Degrees: Bachelor's, Master's, and Ph.D.'s
Positions: Full-time and Interns
Citizenship Requirement: U.S. Citizen or Permanent Resident
Collecting Resume's?: Yes

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Careers / Jobs Sun, 27 Jan 2019 14:39:03 -0500 2019-01-29T18:00:00-05:00 2019-01-29T19:00:00-05:00 Electrical Engineering and Computer Science Building Tau Beta Pi Careers / Jobs Company Icon
Bioethics Discussion: Gender (January 29, 2019 7:00pm) https://events.umich.edu/event/49430 49430-11453774@events.umich.edu Event Begins: Tuesday, January 29, 2019 7:00pm
Location: Lurie Biomedical Engineering
Organized By: The Bioethics Discussion Group

A roundtable discussion on who we are, who society sees, and who we want to be.

Readings to consider:
"Doing gender"
"For whom the burden tolls"
"Performative acts and gender constitution"
"The restroom revolution: unisex toilets and campus politics"

For more information and/or to receive a copy of the readings, please contact Barry Belmont at belmont@umich.edu or visit https://belmont.bme.umich.edu/bioethics-discussion-group/discussions/024-gender/.

Take a look at the blog: https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Sat, 15 Sep 2018 03:29:55 -0400 2019-01-29T19:00:00-05:00 2019-01-29T20:30:00-05:00 Lurie Biomedical Engineering The Bioethics Discussion Group Lecture / Discussion Gender
Department of Computational Medicine & Bioinformatics Weekly Seminar (January 30, 2019 4:00pm) https://events.umich.edu/event/60411 60411-14875271@events.umich.edu Event Begins: Wednesday, January 30, 2019 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Robert A. Coleman, PhD (Asst. Prof., Department of Anatomy and Structural Biology in the Gruss-Lipper Biophotonics Center at the Albert Einstein College of Medicine) will present the following abstract: Years of biochemical experiments have led to the identification of the eukaryotic transcription machinery and a static view of gene regulation. However, mechanisms controlling the dynamics of transcriptional regulation inside a crowded nucleus remains poorly understood. Recent advances in single molecule imaging have begun to shine light on these mechanisms, providing an unprecedented dynamic view of transcriptional regulation in live cells. We and others have found that transcription factors form dynamic hubs of activity in select nuclear compartments. I will discuss how formation of these hubs and recognition of genomic targets is regulated by interactions between transcription factors and the histone tails of chromatin. Transcription factors cycle on and off of their chromatin targets within these hubs on the order of seconds that likely reflect dynamic rates of chromatin remodeling, RNA Polymerase II convoy formation and transcriptional output of a gene. These findings are put into context describing how expression of the p21 cell cycle arrest gene is dynamically regulated by the tumor suppressor p53 protein and chromatin remodelers.

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Lecture / Discussion Fri, 25 Jan 2019 16:10:59 -0500 2019-01-30T16:00:00-05:00 2019-01-30T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
RNA Innovation Seminar, Theme: Medicinal Chemistry (February 4, 2019 3:00pm) https://events.umich.edu/event/59715 59715-14780096@events.umich.edu Event Begins: Monday, February 4, 2019 3:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

1.) Brittany Morgan, Ph.D.
from the Anna Mapp lab
Title of talk: “Rational Approaches to Design and Synthesize RNA-Biased Small Molecule Libraries”

2.) Andrew Robertson, Ph.D.
from the Sherman lab
Title of talk: “Towards the Treatment of HIV: Isolation and Structural Characterization of Natural Product Nef Inhibitors”

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Lecture / Discussion Tue, 15 Jan 2019 15:35:03 -0500 2019-02-04T15:00:00-05:00 2019-02-04T16:00:00-05:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion flyer
Chemistry: Much More than Just a Magic Trick (February 5, 2019 5:30pm) https://events.umich.edu/event/58972 58972-14628137@events.umich.edu Event Begins: Tuesday, February 5, 2019 5:30pm
Location: Off Campus Location
Organized By: Osher Lifelong Learning Institute (50+)

Do you ever wonder about the chemical differences between gin and rum? Or how about the science behind the baking of your favorite pastry or getting the perfect sear on your steak? And what about all the plastic we use in our daily lives? If so, your queries can all be answered through chemistry, and this course will focus on the magical chemical processes used in our everyday lives! So come join us to learn how to think like chemists as we discuss these topics and any others you might have in mind! As graduate students working towards our Ph.D.s in organic chemistry, we share a passion for science and look toward sharing our “magic tricks” with you.

Instructors Ellen Aguilera and Liz Meucci with lead these sessions for those 50 and above. The Study Group will meet on Tuesdays from 5:30 -7 p.m. and run from February 5 through March 12.

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Class / Instruction Thu, 27 Dec 2018 19:14:41 -0500 2019-02-05T17:30:00-05:00 2019-02-05T19:00:00-05:00 Off Campus Location Osher Lifelong Learning Institute (50+) Class / Instruction OLLI Study Group
State of the Union 2019 Debrief (February 6, 2019 1:00pm) https://events.umich.edu/event/60189 60189-14917072@events.umich.edu Event Begins: Wednesday, February 6, 2019 1:00pm
Location: Off Campus Location
Organized By: Engaging Scientists in Policy and Advocacy

Join us for lunch and discussion focused on the 2019 State of the Union, and reflections on this year in science policy. RSVP so we can order enough food: https://goo.gl/forms/wwJeexu2J4nsoRls1

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Meeting Wed, 30 Jan 2019 11:50:30 -0500 2019-02-06T13:00:00-05:00 2019-02-06T14:00:00-05:00 Off Campus Location Engaging Scientists in Policy and Advocacy Meeting SOTU 2019 flyer
Staying one step ahead: fighting unfavorable kinetics in biomass conversion and catalysis (February 6, 2019 4:00pm) https://events.umich.edu/event/56197 56197-13862520@events.umich.edu Event Begins: Wednesday, February 6, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

After atmospheric CO2, lignocellulosic biomass is the second-largest source of renewable carbon on our planet. This makes biomass a very attractive source of sustainable alternatives to fossil-derived chemicals. The production of various chemicals from biomass usually involves the depolymerization of biomass’s three constituent polymers: cellulose and hemicellulose, which are both polysaccharides; and lignin, which is a polymer of phenyl propanoid sub-units. These three types of complex molecules are broken down into their constituent monomers, which include sugars and phenyl propane derivatives. In turn, these low-molecular weight monomers can be catalytically upgraded to either direct or indirect substitutes for petrochemicals. In both depolymerization and catalytic upgrading, the biggest challenge is usually not achieving the desired reaction, but rather avoiding being outcompeted by other, detrimental reactions. Depolymerization reactions of the major biomass constituents – polysaccharides and lignin – are often outpaced by subsequent degradation reactions of sugars and lignin intermediates. In parallel, coking reactions and catalyst deactivation processes plague the upgrading of highly oxygenated and water-miscible biomass derivatives.

In this talk, I will present several solutions to these challenges that my laboratory has developed. I will show how we can use protection group chemistry, both during lignin extraction and polysaccharide depolymerization, to reversibly “trap” stabilized intermediate molecules, and facilitate their high-yield upgrading1,2. Notably, we can show that, under the right conditions, extracted lignin can be catalytically upgraded at high yields to as few as 1-2 major products3. I will also discuss how targeted surface modifications on heterogeneous catalysts can lead to dramatic changes in activity, stability and selectivity, even in the presence of highly oxygenated renewable streams4–6.

References:
1 L. Shuai, M. T. Amiri, Y. M. Questell-Santiago, F. Héroguel, Y. Li, H. Kim, R. Meilan, C. Chapple, J. Ralph and J. S. Luterbacher*, Science, 2016, 354, 329–333.
2 Y. M. Questell-Santiago, R. Zambrano-Varela, M. T. Amiri and J. S. Luterbacher*, Nat. Chem., 2018, 1222–1228.
3 W. Lan, M. T. Amiri, C. M. Hunston and J. S. Luterbacher*, Angew. Chem. Int. Ed., 2018, 57, 1356–1360.
4 F. Héroguel, B. P. Le Monnier, K. S. Brown, J. C. Siu and J. S. Luterbacher*, Appl. Catal. B Environ., 2017, 218, 643–649.
5 F. Héroguel, L. Silvioli, Y.-P. Du and J. S. Luterbacher*, J. Catal., 2018, 358, 50–61.
6 J. H. Yeap, F. Héroguel, R. L. Shahab, B. Rozmysłowicz, M. H. Studer and J. S. Luterbacher*, ACS Catal., 2018, 8, 10769–10773.











Jeremy Luterbacher (École Polytechnique Fédérale de Lausanne)

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Other Wed, 06 Feb 2019 18:15:58 -0500 2019-02-06T16:00:00-05:00 2019-02-06T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
TBP Drop-in Tutoring (February 6, 2019 5:30pm) https://events.umich.edu/event/60828 60828-14970709@events.umich.edu Event Begins: Wednesday, February 6, 2019 5:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Tau Beta Pi

Spend some time helping by fellow students with your classes! Classes include intro Physics, Math, Chemistry, and Engineering courses.

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Class / Instruction Tue, 05 Feb 2019 11:49:37 -0500 2019-02-06T17:30:00-05:00 2019-02-06T19:00:00-05:00 Electrical Engineering and Computer Science Building Tau Beta Pi Class / Instruction tbp-mi
U-M Biological Station Info Session + Faculty Panel (February 7, 2019 6:00pm) https://events.umich.edu/event/60182 60182-14846876@events.umich.edu Event Begins: Thursday, February 7, 2019 6:00pm
Location: Biological Sciences Building
Organized By: University of Michigan Biological Station

STUDENTS: Join us February 7, at 6 p.m. in 1010 Biological Sciences Building (BSB) to learn more about the Biological Station and hear from spring/summer professors about why their class IS THE BEST.

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Rally / Mass Meeting Thu, 24 Jan 2019 09:42:16 -0500 2019-02-07T18:00:00-05:00 2019-02-07T19:00:00-05:00 Biological Sciences Building University of Michigan Biological Station Rally / Mass Meeting Sunset on Douglas Lake.
What makes a C student a C student? (February 8, 2019 12:00pm) https://events.umich.edu/event/54390 54390-13576740@events.umich.edu Event Begins: Friday, February 8, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Diane Bunce

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Other Fri, 08 Feb 2019 18:15:52 -0500 2019-02-08T12:00:00-05:00 2019-02-08T14:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: Emergent properties of membrane proximal signaling events (February 8, 2019 4:00pm) https://events.umich.edu/event/53445 53445-13383532@events.umich.edu Event Begins: Friday, February 8, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: In eukaryotes, cell polarity emerges from the complex interplay between plasma membrane and cytoplasmic molecules, most notably phosphatidylinositol phosphate (PIP) lipids, lipid modifying enzymes, small GTPases, and the actin cytoskeleton. In many cases, competition between lipid kinases and phosphatases underlies the production of PIP lipids that become asymmetrically distributed across the plasma membrane. Although many of the enzymes that regulate PIP lipid synthesis in vivo have been identified, questions concerning how PIP lipid phosphorylation reactions are rapidly turned ON and OFF remain unanswered. The Hansen lab has taken a reductionist approach to biochemically reconstitute minimal sets of signaling molecules that control PIP lipid phosphorylation at the plasma membrane. The knowledge gained from our biochemical analysis has provided new insights concerning how lipid modifying enzymes regulate the formation of transient, polarized, and oscillatory PIP lipid signaling reactions in living cells.

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Workshop / Seminar Wed, 02 Jan 2019 16:52:31 -0500 2019-02-08T16:00:00-05:00 2019-02-08T17:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Scott Hanson
TBP Drop-in Tutoring (February 10, 2019 5:30pm) https://events.umich.edu/event/60828 60828-14970719@events.umich.edu Event Begins: Sunday, February 10, 2019 5:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Tau Beta Pi

Spend some time helping by fellow students with your classes! Classes include intro Physics, Math, Chemistry, and Engineering courses.

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Class / Instruction Tue, 05 Feb 2019 11:49:37 -0500 2019-02-10T17:30:00-05:00 2019-02-10T19:00:00-05:00 Electrical Engineering and Computer Science Building Tau Beta Pi Class / Instruction tbp-mi
RNA Innovation Seminar, Theme: Transcriptome analysis (February 12, 2019 3:00pm) https://events.umich.edu/event/59718 59718-15036276@events.umich.edu Event Begins: Tuesday, February 12, 2019 3:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

1.) "RAS-AGO2 interaction-What’s the RISC?"
Sunita Shankar, Ph.D. Research Investigator from Arul Chinnaiyan lab
2.)  "A Urine RNA-based NGS Assay for Prostate Cancer Early Detection"
Andi Cani, Ph.D. candidate from Scott Tomlins lab

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Lecture / Discussion Wed, 13 Feb 2019 12:34:09 -0500 2019-02-12T15:00:00-05:00 2019-02-12T16:00:00-05:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion flyer
DCMB Seminar on Wed 13 Feb || Michael Feig, PhD (Prof. of MSU) (February 13, 2019 3:30pm) https://events.umich.edu/event/60987 60987-15000014@events.umich.edu Event Begins: Wednesday, February 13, 2019 3:30pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract: Biological macromolecules function in dense, crowded cellular environments. Early studies of crowding effects have emphasized volume exclusion effects, but it is becoming clear that frequent non-specific interactions between proteins, nucleic acids, and metabolites may be the more important factor in modulating the structure and dynamics of biomolecules. Computer simulation studies at different scales of a series of models ranging from concentrated homogeneous protein solutions to models of bacterial cytoplasms are presented to explore the effects of non-specific quinary protein-protein interactions on protein stability and dynamics. One focus is on the formation of transient clusters that determine diffusive properties and lead to liquid-liquid phase transitions. The computational results are related to existing experimental data and the challenges and opportunities to expand the current studies to whole-cell modeling in molecular detail are discussed.

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Lecture / Discussion Fri, 08 Feb 2019 14:11:52 -0500 2019-02-13T15:30:00-05:00 2019-02-13T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
TBP Drop-in Tutoring (February 13, 2019 5:30pm) https://events.umich.edu/event/60828 60828-14970710@events.umich.edu Event Begins: Wednesday, February 13, 2019 5:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Tau Beta Pi

Spend some time helping by fellow students with your classes! Classes include intro Physics, Math, Chemistry, and Engineering courses.

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Class / Instruction Tue, 05 Feb 2019 11:49:37 -0500 2019-02-13T17:30:00-05:00 2019-02-13T19:00:00-05:00 Electrical Engineering and Computer Science Building Tau Beta Pi Class / Instruction tbp-mi
P-Chem Student Seminars (February 14, 2019 4:00pm) https://events.umich.edu/event/59056 59056-14677931@events.umich.edu Event Begins: Thursday, February 14, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Yifan Lai, Kevin Skinner

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Other Thu, 14 Feb 2019 18:15:54 -0500 2019-02-14T16:00:00-05:00 2019-02-14T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Startup Career Fair (February 15, 2019 12:00pm) https://events.umich.edu/event/60363 60363-14866463@events.umich.edu Event Begins: Friday, February 15, 2019 12:00pm
Location: Duderstadt Center
Organized By: MPowered Entrepreneurship

Interested in getting a job or internship at a startup? Come to Startup Career Fair to meet some of today's most exciting startups! All majors and years are welcome and encouraged to attend. There will be a variety of internship and full-time opportunities available.

Sign up here! https://tinyurl.com/yddgpnu9

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Careers / Jobs Thu, 24 Jan 2019 15:13:47 -0500 2019-02-15T12:00:00-05:00 2019-02-15T16:00:00-05:00 Duderstadt Center MPowered Entrepreneurship Careers / Jobs Flyer
Science as Art Exhibition- Panel discussion & Awards Reception (February 15, 2019 2:00pm) https://events.umich.edu/event/38185 38185-15056573@events.umich.edu Event Begins: Friday, February 15, 2019 2:00pm
Location: Hatcher Graduate Library
Organized By: Arts at Michigan

Arts at Michigan, ArtsEngine and the Science Learning Center invite you to the Science as Art Contest Exhibition and Awards Reception- Hatcher Graduate Library, Rm 100.

2pm Office Hours for participating artists
3pm Panel Discussion & Reception
4pm Awards Announcements


University of Michigan undergraduate students will have artwork on view expressing a scientific principle, concept, idea, process, or structure. The artwork ranges in media, including visual, literary, musical, video and performance-based art. A juried panel using criteria based on both scientific and artistic considerations will choose winning submissions. This is our fourth year of the exhibition, and we received a record number of submissions, so we hope you'll join us to view the work and give out the awards!

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Exhibition Thu, 30 Jan 2020 11:57:18 -0500 2019-02-15T14:00:00-05:00 2019-02-15T16:00:00-05:00 Hatcher Graduate Library Arts at Michigan Exhibition Science as Art logo
Seminar Title: TBA (February 15, 2019 4:00pm) https://events.umich.edu/event/53446 53446-13383533@events.umich.edu Event Begins: Friday, February 15, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: TBA

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Workshop / Seminar Wed, 03 Oct 2018 13:51:20 -0400 2019-02-15T16:00:00-05:00 2019-02-15T17:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Dolnald Hamelberg
TBP Drop-in Tutoring (February 17, 2019 5:30pm) https://events.umich.edu/event/60828 60828-14970720@events.umich.edu Event Begins: Sunday, February 17, 2019 5:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Tau Beta Pi

Spend some time helping by fellow students with your classes! Classes include intro Physics, Math, Chemistry, and Engineering courses.

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Class / Instruction Tue, 05 Feb 2019 11:49:37 -0500 2019-02-17T17:30:00-05:00 2019-02-17T19:00:00-05:00 Electrical Engineering and Computer Science Building Tau Beta Pi Class / Instruction tbp-mi
Nitrogen Binding and Fixation using Iron Complexes (February 19, 2019 4:00pm) https://events.umich.edu/event/55303 55303-13716036@events.umich.edu Event Begins: Tuesday, February 19, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Nitrogen reduction (or "fixation") has been a longstanding target of study in chemistry because of the compelling goal of utilizing abundant, cheap atmospheric nitrogen for chemical synthesis. Current methods reduce nitrogen to ammonia at high temperatures and pressures. This seminar will discuss our research into low-temperature nitrogen fixation, as well as new mechanisms that lead to organic products from nitrogen. One of our strategies borrows from the natural enzyme, nitrogenase, which uses an unusual iron-sulfur cluster whose atomic-level mechanism is mysterious. This motivates the development of iron-sulfur complexes with unusual shapes, and study of their interactions with nitrogen and other nitrogenase substrates. Another strategy involves low-coordinate iron coordination compounds, which display new mechanisms for breaking the N-N bond of nitrogen. Studies on low-valent iron compounds have led to the first example of converting nitrogen and arenes directly into aniline products.




Pat Holland (Yale University)

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Other Tue, 19 Feb 2019 18:15:48 -0500 2019-02-19T16:00:00-05:00 2019-02-19T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
DCMB Weekly Seminar (February 20, 2019 3:30pm) https://events.umich.edu/event/61211 61211-15052055@events.umich.edu Event Begins: Wednesday, February 20, 2019 3:30pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Nephrotic syndrome (NS), a kidney disease caused by failure of the glomerular filtration barrier, leads to substantial morbidity and mortality due to infection, clotting, and progression to chronic kidney disease. Our ability to effectively care for our patients with NS is hampered by a limited understanding of its underlying molecular mechanisms. Major progress has been made through the discovery of more than 50 single-gene causes of NS. But altogether these explain less than 15% of cases in the U.S. To gain a more complete picture of the genetic architecture of NS, we need to go beyond Mendelian gene discovery. In this seminar, I will present work done by our group to achieve this goal, with a particular focus on unique opportunities that result from integrating genome-scale omics datasets with deep phenotypic data in the longitudinal NEPTUNE NS cohort.

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Lecture / Discussion Thu, 14 Feb 2019 11:57:44 -0500 2019-02-20T15:30:00-05:00 2019-02-20T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
TBP Drop-in Tutoring (February 20, 2019 5:30pm) https://events.umich.edu/event/60828 60828-14970711@events.umich.edu Event Begins: Wednesday, February 20, 2019 5:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Tau Beta Pi

Spend some time helping by fellow students with your classes! Classes include intro Physics, Math, Chemistry, and Engineering courses.

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Class / Instruction Tue, 05 Feb 2019 11:49:37 -0500 2019-02-20T17:30:00-05:00 2019-02-20T19:00:00-05:00 Electrical Engineering and Computer Science Building Tau Beta Pi Class / Instruction tbp-mi
Panoptic Mass Spectrometry: How and Why? (February 21, 2019 4:00pm) https://events.umich.edu/event/59307 59307-14730588@events.umich.edu Event Begins: Thursday, February 21, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The complexity of contemporary research requires interdisciplinary efforts, and mass spectrometry (MS) is poised to play an important role. The presentation is intended to demonstrate two recent MS experiments designed to facilitate (1) the detection of every ionic species originating from the ion source and (2) an on-demand diagnostic strategy for the under-served population.









Abraham Badu-Tawiah (Ohio State University)

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Other Thu, 21 Feb 2019 18:15:52 -0500 2019-02-21T16:00:00-05:00 2019-02-21T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: TBA (February 22, 2019 4:00pm) https://events.umich.edu/event/53447 53447-13383534@events.umich.edu Event Begins: Friday, February 22, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: TBA

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Workshop / Seminar Wed, 03 Oct 2018 13:52:23 -0400 2019-02-22T16:00:00-05:00 2019-02-22T17:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Zhend Jie
TBP Drop-in Tutoring (February 24, 2019 5:30pm) https://events.umich.edu/event/60828 60828-14970721@events.umich.edu Event Begins: Sunday, February 24, 2019 5:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Tau Beta Pi

Spend some time helping by fellow students with your classes! Classes include intro Physics, Math, Chemistry, and Engineering courses.

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Class / Instruction Tue, 05 Feb 2019 11:49:37 -0500 2019-02-24T17:30:00-05:00 2019-02-24T19:00:00-05:00 Electrical Engineering and Computer Science Building Tau Beta Pi Class / Instruction tbp-mi
Book Talk and Signing - Sicker, Fatter, Poorer: The Urgent Threat of Hormone-Disrupting Chemicals to Our Health and Future... And What We Can Do About It (February 25, 2019 4:30pm) https://events.umich.edu/event/61074 61074-15027213@events.umich.edu Event Begins: Monday, February 25, 2019 4:30pm
Location: Public Health II
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

The Michigan Lifestage Environmental Exposures and Disease Center (M-LEEaD) presents a book talk by Dr. Leo Trasande who will be speaking about his recent publication Sicker, Fatter, Poorer: The Urgent Threat of Hormone-Disrupting Chemicals to Our Health and Future... and What We Can Do About It in conversation with Dr. Mona Hanna-Attisha, author of the 2018 book What the Eyes Don't See: A Story of Crisis, Resistance, and Hope in an American City.

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Lecture / Discussion Mon, 11 Feb 2019 15:32:02 -0500 2019-02-25T16:30:00-05:00 2019-02-25T18:30:00-05:00 Public Health II Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Book Talk Flyer
Dissonance Event Series: Genetics & Medical Apps: Ethics, Privacy, Law and Policy (February 25, 2019 6:00pm) https://events.umich.edu/event/60952 60952-14990967@events.umich.edu Event Begins: Monday, February 25, 2019 6:00pm
Location: Rackham Graduate School (Horace H.)
Organized By: Information Assurance

Each new genetic test or medical app generates or collects more and more detailed health data, but may also raise serious issues for medicine, public health. Under what circumstances should a test be used, and how should it be implemented? Should people be allowed to choose or refuse a test, or should it be mandatory, as newborn screening is in some states? How should the data from these tests be used, and should individuals control access to the results of their tests? If test results are released to third parties, such as employers or insurers, what protections should be in place to protect individuals from unfair treatment based on test results, data collected, or genotype?

This Dissonance series event will take a multi-disciplinary look at these issues from a variety of theoretical and applied perspectives.

Panelists will include:
- Lori Andrews, Professor of Law and Director of the Institute for Science, Law and, Technology at Chicago Kent Law School

- Jodyn Platt, Assistant Professor, U-M Medical School

- Kayte Spector-Bagdady, Assistant Professor, U-M Medical School, Chief of the Research Ethics Service in the Center for Bioethics and Social Sciences in Medicine (CBSSM)

- Denise Anthony, Professor, U-M School of Public Health

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Lecture / Discussion Wed, 20 Feb 2019 16:08:57 -0500 2019-02-25T18:00:00-05:00 2019-02-25T19:30:00-05:00 Rackham Graduate School (Horace H.) Information Assurance Lecture / Discussion Genetics & Medical Apps Panel Discussion
Forum on Climate Change & Health -- What the Science Says & What We Can Do (February 26, 2019 3:30pm) https://events.umich.edu/event/59580 59580-14754546@events.umich.edu Event Begins: Tuesday, February 26, 2019 3:30pm
Location: Palmer Commons
Organized By: Center for Midlife Science

The program includes: a keynote discussion (3:30-5:00 pm) in Forum Hall followed by a reception concluding the event (5:00-6:00 pm). The keynote panel will be live-streamed and recorded for later viewing.
Register (free) here: https://goo.gl/forms/3uK2Qj8SztrhzK4o2
Keynote Panel Live Stream: https://youtu.be/s9zCthg0G8M
This event is organized by the UM Center on Lifestage Environmental Exposures and Disease (M-LEEaD), NIEHS grant P30ES017885 and is co-sponsored by the School of Environment and Sustainability (SEAS), and UM SPH Department of Environmental Health Sciences.
More information is available here:http://mleead.umich.edu/Event_Climate_Change_and_Health_2019.php

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Workshop / Seminar Wed, 06 Feb 2019 12:29:18 -0500 2019-02-26T15:30:00-05:00 2019-02-26T18:00:00-05:00 Palmer Commons Center for Midlife Science Workshop / Seminar Climate Change & Health
New Frontiers in Catalytic Heteroatom Transfer: (February 26, 2019 4:00pm) https://events.umich.edu/event/52437 52437-12717006@events.umich.edu Event Begins: Tuesday, February 26, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


Heteroatom transfer reactions – frequently used by Nature for both the biosynthesis of natural products and the metabolism of xenobiotics – are fundamentally useful for the synthesis of pharmaceuticals and other bioactive compounds. As an example of one application, the site-selective oxidation of carbon-hydrogen bonds can be a powerful tool, especially when applied to late-stage functionalization. Transition metal catalysis of site-selective C–H oxidation has rapidly advanced in recent years, but there are nevertheless substantial challenges that remain with regards to achieving catalyst-controlled selectivity. Research in the Hilinski lab has focused on advancing organocatalysis as an alternative approach to transition metal catalysis of C–H functionalization, in order to exploit its potential advantages and complementarity. In this presentation, multiple approaches to organocatalytic C–H oxidation that have resulted in methods for C–H hydroxylation and the first organocatalytic method for C–H amination will be presented, with a focus on catalyst design, selectivity in complex settings, and mechanism. More recently, the lab’s focus on applications of catalytic heteroatom transfer has broadened to include other late-stage oxidations relevant to drug discovery (e.g. metabolic N-oxidation) and the discovery of novel cycloaddition reactions initiated by heteroatom transfer. Recent results in these areas will therefore also be presented, with a focus on applications relevant to bioactive small molecule synthesis.







Michael Hilinski (University of Virgina)

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Other Tue, 26 Feb 2019 18:15:30 -0500 2019-02-26T16:00:00-05:00 2019-02-26T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Reactions Can Change the World (February 27, 2019 9:00am) https://events.umich.edu/event/61404 61404-15099303@events.umich.edu Event Begins: Wednesday, February 27, 2019 9:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




LC Campeau (Merck)

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Other Wed, 27 Feb 2019 18:15:38 -0500 2019-02-27T09:00:00-05:00 2019-02-27T10:00:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Toward Exact Quantum Chemistry by a Combination of Stochastic Wave Function Sampling and Deterministic Coupled-Cluster Computations (February 28, 2019 4:00pm) https://events.umich.edu/event/59308 59308-14730589@events.umich.edu Event Begins: Thursday, February 28, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

One of the main goals of electronic structure theory is precise ab initio description of increasingly complex polyatomic systems. It is widely accepted that size extensive methods based on the coupled-cluster (CC) theory are excellent candidates for addressing this goal. Indeed, when applied to molecular properties and chemical reaction pathways, the CC hierarchy, including CCSD, CCSDT, CCSDTQ, etc., rapidly converges to the limit of the exact, full configuration interaction (FCI), diagonalization of the Hamiltonian, allowing one to capture the relevant many-electron correlation effects in a conceptually straightforward manner through particle-hole excitations from a single Slater determinant. One of the key challenges has been how to incorporate higher-than-two-body components of the cluster operator, needed to achieve a quantitative description, without running into prohibitive computational costs of CCSDT, CCSDTQ, and similar schemes, while eliminating failures of the more practical perturbative approximations of the CCSD(T) type in multi-reference situations, such as chemical bond breaking. In this talk, we examine a radically new way of obtaining accurate energetics equivalent to high-level CC calculations, even when electronic quasi-degeneracies become significant, at the small fraction of the computational cost, while preserving the black-box character of single-reference computations. The key idea is a merger of the deterministic formalism, abbreviated as CC(P;Q) [1,2], with the stochastic CI [3,4] and CC [5] Quantum Monte Carlo (QMC) approaches [6]. We also demonstrate that one can take the merger of the stochastic and deterministic ideas to the ultimate level and use it to enable precise extrapolations of the exact, FCI, energetics based on the early stages of FCIQMC propagations [7]. The advantages of the new methodologies will be illustrated by molecular examples, where the goal is to recover the nearly exact, CCSDT and CCSDTQ, and exact, FCI, energetics in situations involving chemical bond dissociations and reaction pathways. Possible extensions of this work to excited electronic states [8] and strongly correlated systems [9] will be mentioned as well.

[1] J. Shen and P. Piecuch, Chem. Phys. 401, 180 (2012); J. Chem. Phys. 136, 144104 (2012); J. Chem. Theory Comput. 8, 4968 (2012).
[2] N. P. Bauman, J. Shen, and P. Piecuch, Mol. Phys. 115, 2860 (2017).
[3] G. H. Booth, A. J. W. Thom, and A. Alavi, J. Chem. Phys. 131, 054106 (2009).
[4] D. Cleland, G. H. Booth, and A. Alavi, J. Chem. Phys. 132, 041103 (2010).
[5] A. J. W. Thom, Phys. Rev. Lett. 105, 263004 (2010).
[6] J. E. Deustua, J. Shen, and P. Piecuch, Phys. Rev. Lett. 119, 223003 (2017); in preparation for J. Chem. Phys.
[7] J. E. Deustua, I. Magoulas, J. Shen, and P. Piecuch, J. Chem. Phys. 149, 151101 (2018).
[8] J. E. Deustua, S. H. Yuwono, J. Shen, and P. Piecuch, to be submitted to J. Chem. Phys.
[9] J. E. Deustua, I. Magoulas, J. Shen, and P. Piecuch, in preparation for Phys. Rev. Lett.



Piotr Piecuch (Michigan State University)

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Other Thu, 28 Feb 2019 18:15:31 -0500 2019-02-28T16:00:00-05:00 2019-02-28T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
TBP Drop-in Tutoring (March 3, 2019 5:30pm) https://events.umich.edu/event/60828 60828-14970722@events.umich.edu Event Begins: Sunday, March 3, 2019 5:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Tau Beta Pi

Spend some time helping by fellow students with your classes! Classes include intro Physics, Math, Chemistry, and Engineering courses.

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Class / Instruction Tue, 05 Feb 2019 11:49:37 -0500 2019-03-03T17:30:00-05:00 2019-03-03T19:00:00-05:00 Electrical Engineering and Computer Science Building Tau Beta Pi Class / Instruction tbp-mi
RNA Innovation Seminar, Theme: Transcriptome analysis (March 4, 2019 3:00pm) https://events.umich.edu/event/59718 59718-14780100@events.umich.edu Event Begins: Monday, March 4, 2019 3:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

1.) "RAS-AGO2 interaction-What’s the RISC?"
Sunita Shankar, Ph.D. Research Investigator from Arul Chinnaiyan lab
2.)  "A Urine RNA-based NGS Assay for Prostate Cancer Early Detection"
Andi Cani, Ph.D. candidate from Scott Tomlins lab

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Lecture / Discussion Wed, 13 Feb 2019 12:34:09 -0500 2019-03-04T15:00:00-05:00 2019-03-04T16:00:00-05:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion flyer
Deciphering patterns in selective small molecule:RNA interactions (March 5, 2019 4:00pm) https://events.umich.edu/event/59464 59464-14745531@events.umich.edu Event Begins: Tuesday, March 5, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

While small molecules offer a unique opportunity to target structural and regulatory elements in therapeutically relevant RNAs, selectivity has been a recurrent challenge in small molecule:RNA recognition. In particular, RNAs tend to be more dynamic and offer less chemical functionality than proteins, and biologically active ligands must compete with the highly abundant and highly structured RNA of the ribosome. Indeed, no small molecule drugs targeting RNAs other than the ribosome are currently available, and our recent survey of the literature revealed little more than one hundred reported chemical probes that target non-ribosomal RNA in biological systems. As part of our efforts to improve small molecule targeting strategies and gain fundamental insights into small molecule:RNA recognition, we are analyzing patterns in both RNA-biased small molecule chemical space and RNA topological space privileged for differentiation. To begin, we identified physicochemical, structural, and spatial properties of biologically active RNA ligands that are distinct from those of protein-targeted ligands. Elaboration of four RNA binding scaffolds into a library enriched with these properties has led to improved recognition of medicinally relevant RNA targets, including viral and long noncoding RNA structures. At the same time, we used pattern recognition protocols to identify RNA topologies that can be differentially recognized by small molecules and have elaborated this technique to visualize conformational changes in RNA secondary structure. We are currently expanding these studies with the ultimate goal of applying these insights to the rapid development of ligands with high affinity and specificity for a wide range of RNA targets, particularly those critical to cancer progression.













Amanda Hargrove (Duke University)

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Other Tue, 05 Mar 2019 18:15:30 -0500 2019-03-05T16:00:00-05:00 2019-03-05T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Coordination chemistry approaches for developing 19F magnetic resonance biosensors (March 6, 2019 4:00pm) https://events.umich.edu/event/53805 53805-13463692@events.umich.edu Event Begins: Wednesday, March 6, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

19F Magnetic resonance imaging (MRI) is an emerging technique for in vivo imaging, showing great promise due to the favorable NMR properties of the fluorine nucleus (high sensitivity, large ppm range) and the lack of detectable fluorine signal in biological systems. Imaging agents can be designed that exhibit either a turn-on or chemical shift response that is selective for a specific biological molecule or event. We are developing a series of metal complexes designed to report on different biological environments associated reductive stress (hypoxia), oxidative stress, changes in pH, metal ion concentration, and enzymatic activity. These sensors act via a switch from a paramagnetic to diamagnetic state upon reduction or oxidation at the metal center. Through careful tuning of the ligand scaffold, we have developed selective sensors for hypoxia and oxidative stress, showing promise for future applications for in vivo detection of these states in both cellular and animal disease models. New enhanced nanoparticle-based platforms based on metal-doped perfluorocarbons will also be discussed.
















Emily Que (The University of Texas at Austin)

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Other Wed, 06 Mar 2019 18:15:31 -0500 2019-03-06T16:00:00-05:00 2019-03-06T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
TBP Drop-in Tutoring (March 6, 2019 5:30pm) https://events.umich.edu/event/60828 60828-14970713@events.umich.edu Event Begins: Wednesday, March 6, 2019 5:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Tau Beta Pi

Spend some time helping by fellow students with your classes! Classes include intro Physics, Math, Chemistry, and Engineering courses.

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Class / Instruction Tue, 05 Feb 2019 11:49:37 -0500 2019-03-06T17:30:00-05:00 2019-03-06T19:00:00-05:00 Electrical Engineering and Computer Science Building Tau Beta Pi Class / Instruction tbp-mi
Biosciences Initiative RNA Faculty Candidate Seminar (March 7, 2019 4:00pm) https://events.umich.edu/event/61952 61952-15241362@events.umich.edu Event Begins: Thursday, March 7, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Center for RNA Biomedicine

“Spatiotemporal regulation of mRNA function in health and neurological disease”

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Lecture / Discussion Thu, 07 Mar 2019 15:04:44 -0500 2019-03-07T16:00:00-05:00 2019-03-07T17:00:00-05:00 Chemistry Dow Lab Center for RNA Biomedicine Lecture / Discussion flyer
High-Precision Analyses of True Single-Molecule Chemistry using Nanopore Methods (March 7, 2019 4:00pm) https://events.umich.edu/event/61219 61219-15054302@events.umich.edu Event Begins: Thursday, March 7, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Measurement of single-molecule reactions can elucidate microscopic mechanisms that are often hidden from ensemble analysis. This presentation report the acid-base titration of a single DNA duplex confined within the wild-type ?-hemolysin (?-HL) nanopore for up to 3 hours. Analysis of the pH-dependent kinetics of >100,000 base flipping events of a single GC base pair using a hidden Markov kinetic model demonstrates that protonation/deprotonation occurs while the base pair is in the intra-helical state. Our experiments correspond to the longest single-molecule chemical reaction kinetic measurements performed using a nanopore.
















Henry White (University of Utah)

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Other Thu, 07 Mar 2019 18:15:30 -0500 2019-03-07T16:00:00-05:00 2019-03-07T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
TBP Drop-in Tutoring (March 10, 2019 5:30pm) https://events.umich.edu/event/60828 60828-14970723@events.umich.edu Event Begins: Sunday, March 10, 2019 5:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Tau Beta Pi

Spend some time helping by fellow students with your classes! Classes include intro Physics, Math, Chemistry, and Engineering courses.

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Class / Instruction Tue, 05 Feb 2019 11:49:37 -0500 2019-03-10T17:30:00-04:00 2019-03-10T19:00:00-04:00 Electrical Engineering and Computer Science Building Tau Beta Pi Class / Instruction tbp-mi
Thesis Defense: "Improving Traveling Wave Ion Mobility Mass Spectrometry for Proteomics" (March 11, 2019 10:00am) https://events.umich.edu/event/60561 60561-14910375@events.umich.edu Event Begins: Monday, March 11, 2019 10:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Sarah Haynes (Advisor: Prof. Brent Martin)

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Other Mon, 11 Mar 2019 18:15:32 -0400 2019-03-11T10:00:00-04:00 2019-03-11T11:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Surfing the excited state energy surface towards new applications in photochemistry and biomedicine (March 12, 2019 12:00pm) https://events.umich.edu/event/57634 57634-14246148@events.umich.edu Event Begins: Tuesday, March 12, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

We present recent work on the study and application of environmentally sensitive excited states. Our central hypothesis is that environmentally sensitive deactivation of the molecular excited state can be used to selectively turn a photo-deprotection reaction ON and OFF. Because photochemistry is a zero-sum competition of the rates of different excited state processes, the manipulation of those rates by the environment selects which pathway is dominant. We discuss applications in material synthesis, biomedical diagnostics and peptide chemistry.













Brett VanVeller (Iowa State University)

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Other Tue, 12 Mar 2019 18:15:32 -0400 2019-03-12T12:00:00-04:00 2019-03-12T13:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: "Symmetry-based Design of Protein Nano-cages" (March 12, 2019 2:00pm) https://events.umich.edu/event/61814 61814-15190876@events.umich.edu Event Begins: Tuesday, March 12, 2019 2:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Ajitha S. Cristie-David (Advisor: Prof. Neil Marsh)

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Other Tue, 12 Mar 2019 18:15:32 -0400 2019-03-12T14:00:00-04:00 2019-03-12T15:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
DCMB Weekly Seminar (March 13, 2019 3:30pm) https://events.umich.edu/event/61972 61972-15250104@events.umich.edu Event Begins: Wednesday, March 13, 2019 3:30pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract: Though the potential impact of machine learning in healthcare warrants genuine enthusiasm, the increasing computerization of the field is still often seen as a negative rather than a positive. The limited adoption of machine learning in healthcare to date highlights the fact that there remain important challenges. In this talk, I will highlight two key challenges related to applying machine learning in healthcare: 1) interpretability and 2) small sample size. First, machine learning has often been criticized for producing ‘black boxes.’ In this talk, I will argue that interpretability is neither necessary nor sufficient, demonstrating that even interpretable models can lack common sense. To address this issue, we propose a novel regularization method that enables the incorporation of domain knowledge during model training, leading to increased robustness. Second, machine learning techniques benefit from large amounts of data. However, oftentimes in healthcare we find ourselves in data poor settings (i.e., small sample sizes). I will show how domain knowledge can help guide architecture choices and efficiently make use of available data. There’s a critical need for machine learning in healthcare; however, the safe and meaningful adoption of these techniques requires close collaboration in interdisciplinary teams and a careful understanding of one’s domain.

Jenna Wiens is a Morris Wellman Assistant Professor of Computer Science and Engineering (CSE) at the University of Michigan in Ann Arbor. Her primary research interests lie at the intersection of machine learning, data mining, and healthcare. She is particularly interested in time-series analysis and transfer/multitask learning. The overarching goal of her research agenda is to develop the computational methods needed to help organize, process, and transform patient data into actionable knowledge. Jenna received her PhD from MIT in 2014. In 2015 she was named Forbes 30 under 30 in Science and Healthcare; she received an NSF CAREER Award in 2016; and recently she was named to the MIT Tech Review's list of Innovators Under 35.

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Lecture / Discussion Fri, 08 Mar 2019 15:45:04 -0500 2019-03-13T15:30:00-04:00 2019-03-13T17:00:00-04:00 Palmer Commons DCMB Seminar Series Lecture / Discussion Jenna Wiens, PhD
Biosciences Initiative RNA Faculty Candidate Seminar (March 13, 2019 4:00pm) https://events.umich.edu/event/61951 61951-15241354@events.umich.edu Event Begins: Wednesday, March 13, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Center for RNA Biomedicine

“Uncovering post-transcriptional regulatory mechanisms underlying human diseases Through CRISPR-based screening strategies”

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Lecture / Discussion Thu, 07 Mar 2019 14:58:32 -0500 2019-03-13T16:00:00-04:00 2019-03-13T17:00:00-04:00 Chemistry Dow Lab Center for RNA Biomedicine Lecture / Discussion flyer
TBP Drop-in Tutoring (March 13, 2019 5:30pm) https://events.umich.edu/event/60828 60828-14970714@events.umich.edu Event Begins: Wednesday, March 13, 2019 5:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Tau Beta Pi

Spend some time helping by fellow students with your classes! Classes include intro Physics, Math, Chemistry, and Engineering courses.

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Class / Instruction Tue, 05 Feb 2019 11:49:37 -0500 2019-03-13T17:30:00-04:00 2019-03-13T19:00:00-04:00 Electrical Engineering and Computer Science Building Tau Beta Pi Class / Instruction tbp-mi
P-Chem Student Seminars (March 14, 2019 4:00pm) https://events.umich.edu/event/59057 59057-14677932@events.umich.edu Event Begins: Thursday, March 14, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Alan Rask, Audrey Eshun

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Other Thu, 14 Mar 2019 18:15:51 -0400 2019-03-14T16:00:00-04:00 2019-03-14T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
CSIE|UM: Getting Started Today: Creative Strategies to Establish & Fund Excellent Undergraduate Research at Small Universities (March 15, 2019 12:00pm) https://events.umich.edu/event/61164 61164-15045283@events.umich.edu Event Begins: Friday, March 15, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


Establishing a successful undergraduate research program can be challenging, particularly at a small college or university where most faculty are not involved in research and startup packages are not offered. Jeff has been able to develop creative, collaborative, self-funding strategies which have allowed him to set up research programs for his undergraduate students in industry (AbbVie, Lilly), academia (Duquesne, Harvard), government (NIH), and others (DNDi). In this discussion he will share tips and challenges and explain how the reputation, relationships, and research you are establishing today in graduate school or in your postdoc can provide numerous opportunities for launching and sustaining an excellent undergraduate research program or business in the future.






Jeffrey Rohde (Franciscan University of Steubenville)

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Other Fri, 15 Mar 2019 18:15:48 -0400 2019-03-15T12:00:00-04:00 2019-03-15T13:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Early Career Scientists Symposium: Stable isotopes in ecology, evolution and conservation (March 16, 2019 8:00am) https://events.umich.edu/event/59920 59920-14797491@events.umich.edu Event Begins: Saturday, March 16, 2019 8:00am
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

We are pleased to announce this year's Early Career Scientist Symposium, to be held on Saturday, March 16, 2019, in the Biological Sciences Building on the campus of the University of Michigan, Ann Arbor. This location is the new building that houses the Department of Ecology and Evolutionary Biology; the Department of Molecular, Cellular, and Developmental Biology; the Museum of Paleontology; as well as the Natural History Museum.

This year’s theme is Stable Isotopes in Ecology, Evolution, and Conservation. Stable isotopes of common and trace elements have a wide range of applications in modern and ancient ecosystems. They offer important tools for investigating plant and animal physiology, dietary ecology, life history, food-web analysis, nutrient cycling, migration, and paleoecology, with new isotope systems, new approaches, and new kinds of questions emerging in every decade. Our speakers in the 2019 symposium have expertise in terrestrial and marine systems, modern and ancient ecosystems, and animals, plants, and microbes. The symposium will feature topics for a broad range of interests in ecology, evolution, earth history, and conservation.

We are pleased to announce our lineup of speakers, including our keynote speakers: Jim Ehleringer (plant physiology and ecology), University of Utah, and Tamsin O’Connell (diet and climate in humans and animals), Cambridge University. You can read more about all of the speakers under the speaker tab on the ECSS website.

Graduate and undergraduate students and postdocs from all universities and disciplines are invited to present their work during a lunchtime poster session, and can indicate so when they register. University of Michigan students from EEB and Paleo are particularly encouraged to show their own work and seek feedback from the scholars in attendance. Read about poster specifications on the website.

Registration is open for ECSS 2019 on website linked below.
https://sites.lsa.umich.edu/ecss/home/register/ (copy and paste into your browser if needed)

ECSS 2019 Committee
Jake Allgeier, EEB
Giorgia Auteri, EEB
Catherine Badgley, EEB and Museum of Paleontology, Chair, ECSS Committee
Dan Fisher, Earth and Environmental Sciences, Museum of Paleontology, and EEB
Katie Loughney, EEB and Museum of Paleontology
Knute Nadelhoffer, EEB and UM Biological Station
Ben Passey, Earth and Environmental Sciences
Bian Wang, Earth and Environmental Sciences and Museum of Paleontology

Illustration: Gradient of deuterium, the heavy isotope of hydrogen, across the U.S. by John Megahan

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Conference / Symposium Tue, 12 Mar 2019 10:47:38 -0400 2019-03-16T08:00:00-04:00 2019-03-16T18:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Conference / Symposium Gradient of deuterium, the heavy isotope of hydrogen, across the U.S. Illustration: John Megahan
TBP Drop-in Tutoring (March 17, 2019 5:30pm) https://events.umich.edu/event/60828 60828-14970724@events.umich.edu Event Begins: Sunday, March 17, 2019 5:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Tau Beta Pi

Spend some time helping by fellow students with your classes! Classes include intro Physics, Math, Chemistry, and Engineering courses.

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Class / Instruction Tue, 05 Feb 2019 11:49:37 -0500 2019-03-17T17:30:00-04:00 2019-03-17T19:00:00-04:00 Electrical Engineering and Computer Science Building Tau Beta Pi Class / Instruction tbp-mi
Studies of RNA methylation and chromatin architecture (March 18, 2019 4:00pm) https://events.umich.edu/event/53789 53789-13461546@events.umich.edu Event Begins: Monday, March 18, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Over 150 types of post-transcriptional RNA modifications have been identified in all kingdoms of life. We have discovered the first two RNA demethylases, FTO and ALKBH5, which catalyze oxidative demethylation of the most prevalent modifications of mammalian messenger RNA (mRNA) and other nuclear RNA, N6-methyladenosine (m6A). These findings indicate that reversible RNA modification could impact biological regulation analogous to the well-known reversible DNA and histone chemical modifications. We have also characterized proteins that selectively recognize m6A-modified mRNA and affect the translation status and lifetime of the target mRNA, as well as molecular machines that deposit the m6A methylation on mRNA. Functional studies reveal m6A methylation as a critical mechanism to synchronize groups of transcripts for coordinated metabolism, translation, and decay, allowing timely and coordinated protein synthesis and transcriptome switching during cell differentiation and development. Misregulations of these processes lead to embryo lethality and human diseases such as cancer. I will also present recent studies on developing chemical platforms for proximity capture in probing DNA-DNA proximity.






Chuan He (University of Chicago)

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Other Mon, 18 Mar 2019 18:15:41 -0400 2019-03-18T16:00:00-04:00 2019-03-18T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Alcohol and Amine Derivatives Guide Position-Selective C–H Functionalization Reactions (March 19, 2019 4:00pm) https://events.umich.edu/event/51507 51507-12126782@events.umich.edu Event Begins: Tuesday, March 19, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Free radical reactions represent an important and versatile class of chemical transformations. Nitrogen-centered radical applications remain underexplored due to the lack of convenient methods for their generation. Recent advances have improved access to nitrogen-centered radicals through photoredox-mediated oxidation of two such directing groups: amides and sulfonamides. Guided by this approach, we hypothesized that alcohols, masked as sulfamate esters, and amines, masked as sulfamides, could engage in photoredox-mediated oxidation to furnish nitrogen-centered radicals that could guide C–H functionalization reactions.
Moreover, our directed technology has been inspired by one of the most reliable and powerful known reactions to guide C–H functionalization reactions: the Hofmann–Löffler–Freytag (HLF) reaction, which uses amines or amides as directing groups. Like many of the most robust radical-mediated technologies to direct the activation of tertiary and secondary centers, the HLF reaction is guided through 1,5-hydrogen-atom transfer (HAT) processes, which proceeds through a kinetically-favorable six-membered ring transition state. By contrast, few reports describe 1,6-HAT with a traceless linker, such as an alcohol masked as a sulfamate ester or an amine masked as a sulfamide, and there are no general strategies to enable masked alcohols or amines to direct functionalization of aliphatic ?-C(sp3)–H centers. This talk will outline this novel strategy to harness alcohols and amines to replace C–H bonds at ?-C(sp3)–H centers, which are not generally accessible to directed functionalization. We will demonstrate that C–H abstraction can be robustly coupled with varied functionalization reactions. This talk will highlight one of the first generalizable synthetic strategies to functionalize ?-C(sp3)–H bonds based on masked alcohols or amines, to push the boundaries of organic chemistry at a fundamental level and benefits drug discovery.











Jennifer Roizen (Duke University)

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Other Tue, 19 Mar 2019 18:15:46 -0400 2019-03-19T16:00:00-04:00 2019-03-19T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Biosciences Initiative RNA Faculty Candidate Seminar (March 20, 2019 10:00am) https://events.umich.edu/event/62054 62054-15282560@events.umich.edu Event Begins: Wednesday, March 20, 2019 10:00am
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

“Spatiotemporal regulation of mRNA function in health and neurological disease”

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Lecture / Discussion Tue, 12 Mar 2019 10:33:02 -0400 2019-03-20T10:00:00-04:00 2019-03-20T11:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion flyer
DCMB Seminar || "Towards a phylogeny of cell types" (March 20, 2019 3:30pm) https://events.umich.edu/event/62260 62260-15337499@events.umich.edu Event Begins: Wednesday, March 20, 2019 3:30pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Single-cell RNA-seq is a powerful technology for identifying novel and known cell types, however its power is limited to organisms with well-annotated genomes. We present a reference-free method to compare single cells both within and across species. In this method, k-mers from each cell’s RNA-seq profile are randomly subsampled into a compressed representation called a “sketch” using document comparison algorithms of MinHash or HyperLogLog. For within-species comparison, the RNA sketches are sufficient, but as protein sequence is more stable across species, we translate the RNA k-mers into protein k-mers with 6-frame translation, discarding all protein k-mers containing stop codons. We show this method can “lift over” single-cell RNA-seq annotations from mouse to human and compare to using purely 1:1 mapping orthologous genes. Thus, k-mer sketches are an efficient method to find shared and unique cell types both within and across species without need for a reference genome or transcriptome.

Refreshments: 3:30 pm to 4:00 pm in Atrium Hall, 4th Floor of Palmer Commons
Lecture: 4:00 pm to 5:00 pm in Forum Hall, 4th Floor of Palmer Commons

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Lecture / Discussion Mon, 18 Mar 2019 14:09:46 -0400 2019-03-20T15:30:00-04:00 2019-03-20T17:00:00-04:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
TBP Drop-in Tutoring (March 20, 2019 5:30pm) https://events.umich.edu/event/60828 60828-14970715@events.umich.edu Event Begins: Wednesday, March 20, 2019 5:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Tau Beta Pi

Spend some time helping by fellow students with your classes! Classes include intro Physics, Math, Chemistry, and Engineering courses.

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Class / Instruction Tue, 05 Feb 2019 11:49:37 -0500 2019-03-20T17:30:00-04:00 2019-03-20T19:00:00-04:00 Electrical Engineering and Computer Science Building Tau Beta Pi Class / Instruction tbp-mi
P-Chem Student Seminars (March 21, 2019 4:00pm) https://events.umich.edu/event/59058 59058-14677933@events.umich.edu Event Begins: Thursday, March 21, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Yanbing Zhou, Joseph Meadows

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Other Thu, 21 Mar 2019 18:15:44 -0400 2019-03-21T16:00:00-04:00 2019-03-21T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
A Transcript for all Reasons: RNA Biomedicine (March 21, 2019 5:00pm) https://events.umich.edu/event/62192 62192-15311060@events.umich.edu Event Begins: Thursday, March 21, 2019 5:00pm
Location: Frankel Cardiovascular Center
Organized By: Department of Chemistry

Sequencing of the human genome has led to the discovery that while less than two percent of the genome codes for proteins, most of it — perhaps greater than 90 percent — is primarily dedicated to making a wide variety of RNA molecules. These RNAs have been implicated in diverse biological activities and diseases, opening new approaches to personalized medical treatment.



The co-directors of the U-M Center for RNA Biomedicine, Mats Ljungman and Nils Walter, will outline the tools now available to study and manipulate RNA and how they have the potential to build a bridge from laboratory to clinic. They also will outline their vision for accelerating RNA research at UM through the recent funding obtained from Biosciences Initiative.

These talks are open to everyone and free, but please register.

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Lecture / Discussion Fri, 15 Mar 2019 13:31:13 -0400 2019-03-21T17:00:00-04:00 2019-03-21T18:00:00-04:00 Frankel Cardiovascular Center Department of Chemistry Lecture / Discussion RNA poster presenters in old English costumes
Seminar Title: TBA (March 22, 2019 4:00pm) https://events.umich.edu/event/53448 53448-13383535@events.umich.edu Event Begins: Friday, March 22, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: TBA

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Workshop / Seminar Mon, 06 Aug 2018 15:06:40 -0400 2019-03-22T16:00:00-04:00 2019-03-22T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Sarah Woodson
TBP Drop-in Tutoring (March 24, 2019 5:30pm) https://events.umich.edu/event/60828 60828-14970725@events.umich.edu Event Begins: Sunday, March 24, 2019 5:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Tau Beta Pi

Spend some time helping by fellow students with your classes! Classes include intro Physics, Math, Chemistry, and Engineering courses.

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Class / Instruction Tue, 05 Feb 2019 11:49:37 -0500 2019-03-24T17:30:00-04:00 2019-03-24T19:00:00-04:00 Electrical Engineering and Computer Science Building Tau Beta Pi Class / Instruction tbp-mi
"Comprehensive Discovery of Bacterial Ribozymes and Riboswitches" (March 25, 2019 11:00am) https://events.umich.edu/event/61949 61949-15241352@events.umich.edu Event Begins: Monday, March 25, 2019 11:00am
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Henry Ford II Professor, Department of Molecular, Cellular and Developmental Biology
Professor, Molecular Biophysics and Biochemistry
Investigator, Howard Hughes Medical Institute

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Lecture / Discussion Fri, 22 Mar 2019 10:33:18 -0400 2019-03-25T11:00:00-04:00 2019-03-25T12:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion flyer
If you are going to make a fuel from sunlight, water, and air, what should it be? (March 25, 2019 4:00pm) https://events.umich.edu/event/52155 52155-12488633@events.umich.edu Event Begins: Monday, March 25, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Electrocatalysts for the reduction of CO2 are of interest in the production of solar fuels, and as a means of mitigating atmospheric CO2. The question of which solar fuels should be made from CO2 is an important one. Unlike water splitting (H2O ? H2 + ½ O2) where a single reduced product (H2) is obtained, the reduction of CO2 can produce a variety of different chemical reduction products, CO, HCOOH, H2CO, CH3OH, CH4, to name a few, as well as C2 and higher products. Which product(s) will be produced from solar energy, and then be used as building blocks to manufacture higher fuels and specialty chemicals is not presently known. Indeed, the question of whether CO2 should be reduced electrochemically to an organic molecule, or instead, hydrogen produced by water splitting, should be used to hydrogenate CO2 to organic products is not clearly understood at this time. There are very few known catalysts for the efficient hydrogenation of CO2, so whether electrochemical reduction or hydrogenation of CO2 is ultimately practiced on an industrial scale, the development of new catalysts will be required to enable new technology. Results from several recent approaches to producing higher value solar fuels from CO2 including synthetic biology and tandem catalysis are presently under investigation. Several recent accomplishments in the activation and electrochemical reduction of CO2 have been achieved. These include the use of earth-abundant metals including manganese, in place of rhenium and ruthenium, and the use of artificial co-factors to promote catalysis. Other recent approaches to developing catalysts for the reduction of CO2 include the deployment of proton relays in associated ligands to manage proton transport, introduction of new systems in which proton coupled electron transfer for efficient H-atom transfers can be effected, supramolecular catalyst assemblies that use non-covalent interactions to direct catalyst centers toward substrate activation, and artificial metalloprotein electrocatalysts. The general properties of molecular catalysts on conducting substrates under bias as probed by surface spectroscopies pose challenges to researchers attempting to do catalysis at an electrified interface. Surface spectroscopies can provide detailed information about the electronic structure and environmental effects of catalysts operating within the diffusion layer of an electrode under bias.










Cliff Kubiak (University of California San Diego)

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Other Mon, 25 Mar 2019 18:15:38 -0400 2019-03-25T16:00:00-04:00 2019-03-25T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Enantioselective Chemical Synthesis Methods via Cooperative Catalysis: Design, Development and Application (March 26, 2019 4:00pm) https://events.umich.edu/event/57287 57287-14148782@events.umich.edu Event Begins: Tuesday, March 26, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our laboratory has embraced cooperative catalysis as a general framework for the design of new enantioselective reactions. Within this regime we have exploited cooperation between Lewis base and transition metal catalysts as an effective means to control and direct both reaction partners during bond construction. The versatility of this approach is such that each catalyst acts in an orthogonal manner, which permits the role and function of the metal center to be modified and tuned without compromising enantioselectivity. This seminar will describe our most recent efforts in asymmetric carbon–carbon and carbon-nitrogen bond formation.












Thomas Snaddon (Indiana University)

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Other Tue, 26 Mar 2019 18:15:39 -0400 2019-03-26T16:00:00-04:00 2019-03-26T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: "Protein-Protein Interaction Analysis: Expanded Hydrogen/Deuterium Exchange Tandem Mass Spectrometry and Host Cell Protein Characterization" (March 27, 2019 2:00pm) https://events.umich.edu/event/62060 62060-15284703@events.umich.edu Event Begins: Wednesday, March 27, 2019 2:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Qingyi Wang (Thesis Advisor: Prof. Kicki Hakansson)

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Other Wed, 27 Mar 2019 18:15:42 -0400 2019-03-27T14:00:00-04:00 2019-03-27T15:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
DCMB Weekly Seminar (March 27, 2019 3:30pm) https://events.umich.edu/event/61637 61637-15161278@events.umich.edu Event Begins: Wednesday, March 27, 2019 3:30pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Next generation and single cell sequencing have ushered in an era of big data in biology. These data present an unprecedented opportunity to learn new mechanisms and ask unasked questions. Matrix factorization (MF) techniques can reveal low-dimensional structure from high-dimensional data to uncover new biological knowledge. The knowledge of gained from low dimensional features in training data can also be transferred to new datasets to relate disparate model systems and data modalities. We illustrate the power of these techniques for interpretation of high dimensional data through case studies in postmortem tissues from GTEx, acquired therapeutic resistance in cancer, and developmental biology.

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Lecture / Discussion Wed, 20 Mar 2019 11:22:07 -0400 2019-03-27T15:30:00-04:00 2019-03-27T17:00:00-04:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
2019 Ford Distinguished Lecture in Physics | General Relativity: Creator and Killer of Galaxies (March 27, 2019 4:00pm) https://events.umich.edu/event/60963 60963-14997736@events.umich.edu Event Begins: Wednesday, March 27, 2019 4:00pm
Location: Ross School of Business
Organized By: Department Colloquia

The story of galaxy life cycles is becoming clear. Professor and Astronomer Emerita Sandra Faber will take us through the earliest moments of galaxy birth during inflation, the inception of star formation, the gradual emergence of shape and structure, and finally death at the hands of black holes. Explaining the origin of galaxies is emerging as one of the great triumphs of modern physics.

Dr. Sandra Faber is a Professor Emerita at the University of California Santa Cruz and an Astronomer Emerita at the University of California Observatories.

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Lecture / Discussion Fri, 08 Feb 2019 13:23:42 -0500 2019-03-27T16:00:00-04:00 2019-03-27T17:00:00-04:00 Ross School of Business Department Colloquia Lecture / Discussion Sandra Faber, Department of Astronomy and Astrophysics (UCSC)
TBP Drop-in Tutoring (March 27, 2019 5:30pm) https://events.umich.edu/event/60828 60828-14970716@events.umich.edu Event Begins: Wednesday, March 27, 2019 5:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Tau Beta Pi

Spend some time helping by fellow students with your classes! Classes include intro Physics, Math, Chemistry, and Engineering courses.

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Class / Instruction Tue, 05 Feb 2019 11:49:37 -0500 2019-03-27T17:30:00-04:00 2019-03-27T19:00:00-04:00 Electrical Engineering and Computer Science Building Tau Beta Pi Class / Instruction tbp-mi
Thesis Defense: "Enhanced, Live-Cell, Super-Resolution Imaging and Single-Molecule Emission Spectrum Reshaping” (March 28, 2019 1:00pm) https://events.umich.edu/event/62061 62061-15284704@events.umich.edu Event Begins: Thursday, March 28, 2019 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Stephen Lee (Thesis Advisor: Prof. Julie Biteen)

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Other Thu, 28 Mar 2019 18:15:45 -0400 2019-03-28T13:00:00-04:00 2019-03-28T14:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: "Enhanced, Live-Cell, Super-Resolution Imaging and Single-Molecule Emission Spectrum Reshaping" (March 28, 2019 1:00pm) https://events.umich.edu/event/60562 60562-14910376@events.umich.edu Event Begins: Thursday, March 28, 2019 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Stephen Lee (Advisor: Julie Biteen)

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Other Thu, 28 Mar 2019 18:15:45 -0400 2019-03-28T13:00:00-04:00 2019-03-28T14:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Ultrafast Nonlinear IR Spectroscopy for Exotic Molecular Materials (March 28, 2019 4:00pm) https://events.umich.edu/event/57406 57406-14186925@events.umich.edu Event Begins: Thursday, March 28, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


In this seminar, I will discuss two developments of ultrafast nonlinear IR spectroscopy for exotic molecular materials: (1) 2D IR spectroscopy for molecular vibrational polaritons and (2) heterogeneous water dynamics templated by self-assembled materials. Both show the advantages of ultrafast nonlinear IR spectroscopic technique to decipher hidden physics of exotic molecular materials.
2D IR of Molecular Polaritons. Molecular vibrational polaritons, hybrid half-light, half-matter quasiparticles, are studied using ultrafast coherent 2D IR spectroscopy. Molecular vibrational-polaritons are anticipated to open opportunities for new photonic and molecular phenomena. Many of these developments hinge on fundamental understanding of physical properties of molecular vibrational polaritons. Using 2D IR spectroscopy to study vibrational-polaritons, we obtained results that challenge and advance both polariton and spectroscopy fields, which invokes new development of theory for the spectroscopy, observation of new nonlinear optical effects and unexpected responses from hidden dark states These results will have significant implications in novel infrared photonic devices, lasing, molecular quantum simulation, as well as new chemistry by tailoring potential energy landscapes.
Heterogeneous water dynamics templated by self-assembled materials. We report observations of mesoscopically homogeneous but macroscopically heterogenous water dynamics in self-assembled materials by a new, spatially resolved infrared (IR) pump vibrational sum frequency generation (VSFG) probe microscope. We found that the strong hydrogen-bond interactions between host molecules and nearby water not only template nearby water networks to adopt the chirality of self-assembled materials, but also induce resonant energy transfer from ?-CD to nearby water, which is heterogeneous among domains, but uniform within domains.






Wei Xiong (UC-San Diego)

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Other Thu, 28 Mar 2019 18:15:44 -0400 2019-03-28T16:00:00-04:00 2019-03-28T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
4th Annual RNA Symposium (March 29, 2019 8:00am) https://events.umich.edu/event/59721 59721-14780105@events.umich.edu Event Begins: Friday, March 29, 2019 8:00am
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Rachel Green, Johns Hopkins
Howard Chang, Stanford
Alice Telesnitsky, Michigan
Kristen Lynch, Pennsylvania
David Bartel, MIT

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Lecture / Discussion Tue, 12 Mar 2019 10:36:50 -0400 2019-03-29T08:00:00-04:00 2019-03-29T16:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion photos
�Evolution of Blood Gas Testing for Critical Care� (March 29, 2019 12:00pm) https://events.umich.edu/event/61802 61802-15188646@events.umich.edu Event Begins: Friday, March 29, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Sohrab Mansouri (Instrumentation Laboratory, Inc)

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Other Fri, 29 Mar 2019 18:15:39 -0400 2019-03-29T12:00:00-04:00 2019-03-29T13:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: Elevators in cell membrane: structure and dynamics of nutrient transporters (March 29, 2019 4:00pm) https://events.umich.edu/event/53450 53450-13383537@events.umich.edu Event Begins: Friday, March 29, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

ABSTRACT: TBA

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Workshop / Seminar Mon, 25 Mar 2019 09:20:49 -0400 2019-03-29T16:00:00-04:00 2019-03-29T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Ming Zou
TBP Drop-in Tutoring (March 31, 2019 5:30pm) https://events.umich.edu/event/60828 60828-14970726@events.umich.edu Event Begins: Sunday, March 31, 2019 5:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Tau Beta Pi

Spend some time helping by fellow students with your classes! Classes include intro Physics, Math, Chemistry, and Engineering courses.

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Class / Instruction Tue, 05 Feb 2019 11:49:37 -0500 2019-03-31T17:30:00-04:00 2019-03-31T19:00:00-04:00 Electrical Engineering and Computer Science Building Tau Beta Pi Class / Instruction tbp-mi
TBP Drop-in Tutoring (April 3, 2019 5:30pm) https://events.umich.edu/event/60828 60828-14970717@events.umich.edu Event Begins: Wednesday, April 3, 2019 5:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Tau Beta Pi

Spend some time helping by fellow students with your classes! Classes include intro Physics, Math, Chemistry, and Engineering courses.

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Class / Instruction Tue, 05 Feb 2019 11:49:37 -0500 2019-04-03T17:30:00-04:00 2019-04-03T19:00:00-04:00 Electrical Engineering and Computer Science Building Tau Beta Pi Class / Instruction tbp-mi
The Unlikely Friendship of Math and Science (April 3, 2019 5:30pm) https://events.umich.edu/event/62432 62432-15364114@events.umich.edu Event Begins: Wednesday, April 3, 2019 5:30pm
Location: East Hall
Organized By: Department of Mathematics

Abstract: On the one hand, there's science: the clear-eyed, hard-nosed, the pragmatic empiricist. On the other hand, there's math: the poet, the dreamer, the hunter of wild abstractions. How do these two intellectual traditions regard one another? And why is it that the most useless-sounding math - from knot theory to meta-logic to non-Euclidean geometry - often turns out to be the most useful? Prerequisites: basic human curiosity; tolerance for bad drawings; the willingness to participate in a silly debate. In short: all are welcome!

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Lecture / Discussion Thu, 21 Mar 2019 14:15:46 -0400 2019-04-03T17:30:00-04:00 2019-04-03T18:30:00-04:00 East Hall Department of Mathematics Lecture / Discussion Ben Orlin Public Lecture
Seminar Title: “Protein conformational change we can believe in!” (April 5, 2019 4:00pm) https://events.umich.edu/event/53451 53451-13383538@events.umich.edu Event Begins: Friday, April 5, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

ABSTRACT: Protein conformational landscapes are complex and predicting the conformational response to physiologically relevant perturbations like mutation or small molecule binding is a major challenge. Often, functionally-relevant states are nearly isoenergetic (separated in energy by a few kT, or less), meaning that at physiological temperatures, multiple conformational states populate the ensemble. Using newly developed multiconformer models of X-ray crystallography data, we have shown how population shifts can result from simple temperature perturbation. Our experience over multiple systems has demonstrated that temperature sensitive conformational states are the same ones used by evolution to create new functions, by small molecules in creating new binding sites, and by enzymes to transit through a catalytic cycle. Using an easily controllable physical perturbation (temperature) to predict the conformational response to physiological perturbations suggests the specific conformations to enforce at allosteric sites to achieve long-range control over protein activity.

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Workshop / Seminar Wed, 03 Apr 2019 15:41:52 -0400 2019-04-05T16:00:00-04:00 2019-04-05T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar James Fraser
TBP Drop-in Tutoring (April 7, 2019 5:30pm) https://events.umich.edu/event/60828 60828-14970727@events.umich.edu Event Begins: Sunday, April 7, 2019 5:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Tau Beta Pi

Spend some time helping by fellow students with your classes! Classes include intro Physics, Math, Chemistry, and Engineering courses.

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Class / Instruction Tue, 05 Feb 2019 11:49:37 -0500 2019-04-07T17:30:00-04:00 2019-04-07T19:00:00-04:00 Electrical Engineering and Computer Science Building Tau Beta Pi Class / Instruction tbp-mi
RNA Innovation Seminar || Co-sponsored with the Department of Cellular and Developmental Biology (April 8, 2019 3:00pm) https://events.umich.edu/event/59780 59780-14786531@events.umich.edu Event Begins: Monday, April 8, 2019 3:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Anthony Leung, PhD, Associate Professor, Johns Hopkins

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Lecture / Discussion Tue, 15 Jan 2019 11:57:50 -0500 2019-04-08T15:00:00-04:00 2019-04-08T16:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion
TBA (April 9, 2019 4:00pm) https://events.umich.edu/event/62107 62107-15293418@events.umich.edu Event Begins: Tuesday, April 9, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




David Needham (Duke University)

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Other Thu, 14 Mar 2019 06:15:38 -0400 2019-04-09T16:00:00-04:00 2019-04-09T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Bioethics Discussion: Replicability of Medical Studies (April 9, 2019 7:00pm) https://events.umich.edu/event/49436 49436-11456549@events.umich.edu Event Begins: Tuesday, April 9, 2019 7:00pm
Location: Lurie Biomedical Engineering
Organized By: The Bioethics Discussion Group

A roundtable discussion on the significance of our results.

Readings to consider:
"Reproducibility in science"
"Estimating the reproducibility of psychological science"
"How many scientists fabricate and falsify research?"
"Is the replicability crisis overblown?"

For more information and/or to receive a copy of the readings, please contact Barry Belmont at belmont@umich.edu or visit https://belmont.bme.umich.edu/bioethics-discussion-group/discussions/029-replicability-of-medical-studies/.

Or feel free to swing by the blog: https://belmont.bme.umich.edu/incidental-art/.

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Lecture / Discussion Sat, 15 Sep 2018 03:36:18 -0400 2019-04-09T19:00:00-04:00 2019-04-09T20:30:00-04:00 Lurie Biomedical Engineering The Bioethics Discussion Group Lecture / Discussion Replicability of medical studies
DCMB Seminar (April 10, 2019 4:00pm) https://events.umich.edu/event/62715 62715-15434135@events.umich.edu Event Begins: Wednesday, April 10, 2019 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Ophthalmology is heavily dependent on imaging and numerical data, making it an excellent candidate for the application of deep learning to tasks in image analysis and clinical decision support. In this seminar, we will discuss the rapid automated segmentation of anterior segment optical coherence tomography (AS-OCT) and its implications for the clinical investigation of the cornea and the intraoperative guidance of surgical maneuvers. In addition, we will discuss the relevance of deep learning to lens implant selection for cataract surgery -- the most commonly performed surgical procedure in the United States. We will conclude by examining the potential roles for deep learning in the analysis of the SOURCE database -- a comprehensive repository of ophthalmic clinical and imaging data being built at UM Kellogg Eye Center to encompass data across 18 institutions.

3:30 PM - Refreshments in Atrium Hall, Palmer Commons
4:00 PM - Lecture

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Lecture / Discussion Fri, 29 Mar 2019 15:37:32 -0400 2019-04-10T16:00:00-04:00 2019-04-10T17:00:00-04:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
Selective Functionalization of Pyridines, Diazines and Pharmaceuticals via Heterocyclic Phosphonium Salt (April 10, 2019 4:00pm) https://events.umich.edu/event/61846 61846-15219414@events.umich.edu Event Begins: Wednesday, April 10, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Selective methods that can functionalize electron-deficient heterocycles are in great demand due to their prevalence in biologically active compounds. Pyridines and diazines, in particular, are widespread components of pharmaceutical compounds yet methods to transform these motifs into valuable derivatives are still greatly sought after. We will present a selection of catalytic and non-catalytic methods using phosphorus intermediates that enable multiple new bond-constructions on these heterocycles. A particular emphasis will be placed on phosphorus ligand-coupling reactions that represent an alternative means to form C–C and C-Heteroatom bonds.












Andy McNally (Colorado State University)

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Other Wed, 10 Apr 2019 18:15:24 -0400 2019-04-10T16:00:00-04:00 2019-04-10T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
TBP Drop-in Tutoring (April 10, 2019 5:30pm) https://events.umich.edu/event/60828 60828-14970718@events.umich.edu Event Begins: Wednesday, April 10, 2019 5:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Tau Beta Pi

Spend some time helping by fellow students with your classes! Classes include intro Physics, Math, Chemistry, and Engineering courses.

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Class / Instruction Tue, 05 Feb 2019 11:49:37 -0500 2019-04-10T17:30:00-04:00 2019-04-10T19:00:00-04:00 Electrical Engineering and Computer Science Building Tau Beta Pi Class / Instruction tbp-mi
Michigan Quantum Science and Technology Workshop (April 11, 2019 1:00pm) https://events.umich.edu/event/62495 62495-15372993@events.umich.edu Event Begins: Thursday, April 11, 2019 1:00pm
Location: Off Campus Location
Organized By: Physics Workshops & Conferences

One of the near term objectives of the Working Group is to develop a complete picture of the Michigan footprint in quantum science and technology and work to shape the image so that it can be understood in the context of the quantum initiative that is shaping up in the different funding agencies. To help in this process, a workshop is being held in April where speakers from other institutions and organizations will give their perspective on the future in this area. In addition, there will be approximately 5 internal speakers. Each of the internal speakers are working to prepare a description of the focus and impact of an area of research that includes the work of several faculty including themselves. Between the internal speakers, we expect to be able to include almost all the research areas of people who has responded to the invitation to submit their work for inclusion.

Confirmed external speakers include:
Sophia Economou (Virginia Tech)
Dan Gauthier (Ohio State)
Chris Greene (Purdue)
Tony Heinz (Stanford)
Peter Littlewood (U. Chicago)
Igor Markov (Adjunction Prof. Umich))
Johannes Pollanen (Michigan State)
Mike Raymer (U. Oregon)

Any questions? Please contact:
Duncan Steel, Robert J. Hiller Professor
Professor of Electrical Engineering and Computer Science
Professor of Physics
dst@umich.edu
(734) 764-4469

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Workshop / Seminar Wed, 27 Mar 2019 09:46:51 -0400 2019-04-11T13:00:00-04:00 2019-04-11T17:00:00-04:00 Off Campus Location Physics Workshops & Conferences Workshop / Seminar Spectroscopy
Nanoscale Imaging of Chemical Reactivity using Single-Particle Fluorescence Microscopy (April 11, 2019 4:00pm) https://events.umich.edu/event/52808 52808-13081673@events.umich.edu Event Begins: Thursday, April 11, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

I will describe our group’s efforts to understand heterogeneity in the chemical reactivity of semiconductor nanocrystals by imaging reaction events one at a time. In one project, we have used the change in fluorescence intensity to image the transformation of individual lead bromide (PbBr2) nanocrystals to methylammonium lead bromide (CH3NH3PbBr3) via intercalation of CH3NH3Br. Analyzing this reaction one nanocrystal at a time reveals information that is masked when the fluorescence intensity is averaged over many particles. Sharp rises in the intensity of single nanocrystals indicate they transform much faster than the time it takes for the ensemble average to transform. Based on these observations, we propose a phase-transformation model in which the solid-state immiscibility between PbBr2 and CH3NH3PbBr3 initially create a high energy barrier for ion intercalation.
In related work, we have used chemically-triggered fluorogenic probes to study the spatial distribution of catalytically active regions in individual tungsten oxide nanowires using super-resolution fluorescence microscopy. Activation of the first probe molecule requires photoexcitation above the bandgap of the semiconductor to generate hydroxyl radicals. The second reaction does not require photoexcitation but instead relies on the presence of either oxygen vacancies or hydroxyl groups at the surface of the nanowires. Through quantitative, coordinate-based colocalization of probe molecules activated by the same nanowires, we demonstrate that the nanoscale regions most active for the photocatalytic generation of hydroxyl radicals also possess a greater concentration of oxygen vacancies.









Bryce Sadtler (Washington University in St. Louis)

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Other Thu, 11 Apr 2019 18:15:27 -0400 2019-04-11T16:00:00-04:00 2019-04-11T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Michigan Quantum Science and Technology Workshop (April 12, 2019 8:00am) https://events.umich.edu/event/62495 62495-15372992@events.umich.edu Event Begins: Friday, April 12, 2019 8:00am
Location: Off Campus Location
Organized By: Physics Workshops & Conferences

One of the near term objectives of the Working Group is to develop a complete picture of the Michigan footprint in quantum science and technology and work to shape the image so that it can be understood in the context of the quantum initiative that is shaping up in the different funding agencies. To help in this process, a workshop is being held in April where speakers from other institutions and organizations will give their perspective on the future in this area. In addition, there will be approximately 5 internal speakers. Each of the internal speakers are working to prepare a description of the focus and impact of an area of research that includes the work of several faculty including themselves. Between the internal speakers, we expect to be able to include almost all the research areas of people who has responded to the invitation to submit their work for inclusion.

Confirmed external speakers include:
Sophia Economou (Virginia Tech)
Dan Gauthier (Ohio State)
Chris Greene (Purdue)
Tony Heinz (Stanford)
Peter Littlewood (U. Chicago)
Igor Markov (Adjunction Prof. Umich))
Johannes Pollanen (Michigan State)
Mike Raymer (U. Oregon)

Any questions? Please contact:
Duncan Steel, Robert J. Hiller Professor
Professor of Electrical Engineering and Computer Science
Professor of Physics
dst@umich.edu
(734) 764-4469

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Workshop / Seminar Wed, 27 Mar 2019 09:46:51 -0400 2019-04-12T08:00:00-04:00 2019-04-12T17:00:00-04:00 Off Campus Location Physics Workshops & Conferences Workshop / Seminar Spectroscopy
Seminar Titile: 'Structural Biology in situ: The Promise and Challenges of Cryo-Electron Tomography‘ (April 12, 2019 4:00pm) https://events.umich.edu/event/62526 62526-15397102@events.umich.edu Event Begins: Friday, April 12, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Oncley Lecture Series

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Workshop / Seminar Mon, 25 Mar 2019 09:29:31 -0400 2019-04-12T16:00:00-04:00 2019-04-12T17:30:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
TBP Drop-in Tutoring (April 14, 2019 5:30pm) https://events.umich.edu/event/60828 60828-14970728@events.umich.edu Event Begins: Sunday, April 14, 2019 5:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Tau Beta Pi

Spend some time helping by fellow students with your classes! Classes include intro Physics, Math, Chemistry, and Engineering courses.

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Class / Instruction Tue, 05 Feb 2019 11:49:37 -0500 2019-04-14T17:30:00-04:00 2019-04-14T19:00:00-04:00 Electrical Engineering and Computer Science Building Tau Beta Pi Class / Instruction tbp-mi
Thesis Defense: "Investigating the Substrate Selectivity and Regulation of Histone Deacetylases" (April 15, 2019 12:30pm) https://events.umich.edu/event/62810 62810-15470940@events.umich.edu Event Begins: Monday, April 15, 2019 12:30pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Katy Leng (Advisor: Prof.Carol Fierke)

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Other Mon, 15 Apr 2019 18:15:16 -0400 2019-04-15T12:30:00-04:00 2019-04-15T13:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
"Mining the Innate Immune System for Novel Therapeutic Targets " (April 15, 2019 4:00pm) https://events.umich.edu/event/61932 61932-15241338@events.umich.edu Event Begins: Monday, April 15, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Gary Glick

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Other Mon, 15 Apr 2019 18:15:16 -0400 2019-04-15T16:00:00-04:00 2019-04-15T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Seminar Title: TBA (April 15, 2019 4:00pm) https://events.umich.edu/event/62527 62527-15397104@events.umich.edu Event Begins: Monday, April 15, 2019 4:00pm
Location: Rackham Graduate School (Horace H.)
Organized By: LSA Biophysics

Krimm Lecture Series

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Workshop / Seminar Mon, 25 Mar 2019 09:28:50 -0400 2019-04-15T16:00:00-04:00 2019-04-15T17:00:00-04:00 Rackham Graduate School (Horace H.) LSA Biophysics Workshop / Seminar Rackham Graduate School (Horace H.)
Thesis Defense: “Some More Spectroscopy on Vitamin B 12 ” (April 16, 2019 12:15pm) https://events.umich.edu/event/62811 62811-15470941@events.umich.edu Event Begins: Tuesday, April 16, 2019 12:15pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Nick Miller (Advisor: Prof. Roseanne Sension)

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Other Tue, 16 Apr 2019 18:15:24 -0400 2019-04-16T12:15:00-04:00 2019-04-16T13:15:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Supporting students’ understanding of models and modeling in general chemistry (April 16, 2019 4:00pm) https://events.umich.edu/event/62975 62975-15528486@events.umich.edu Event Begins: Tuesday, April 16, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Undergraduate general chemistry courses typically feature a substantial amount of problem solving that involve mathematical and other types of models. Optimally, this type of activity would provide them an entry point into the scientific practice of constructing and using models. But, evidence shows that after participating in traditional approaches to general chemistry students tend to approach mathematical problem solving algorithmically and may struggle to connect mathematical representations to particulate-level ideas. The question becomes: How can we as instructors support students in more meaningful engagement with mathematical and other models in chemistry contexts? Here, we discuss findings from our research into students’ reasoning about different types of models in the general chemistry sequence and discuss potential routes towards promoting more meaningful engagement in model-based reasoning and mathematical thinking.











Nicole Becker (University of Iowa)

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Other Tue, 16 Apr 2019 18:15:24 -0400 2019-04-16T16:00:00-04:00 2019-04-16T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Winter 2020 Walk-in Advising! (April 17, 2019 1:00pm) https://events.umich.edu/event/63011 63011-15534811@events.umich.edu Event Begins: Wednesday, April 17, 2019 1:00pm
Location: Weiser Hall
Organized By: Center for Global and Intercultural Study

Don’t wait until the September 15th deadline, join CGIS & Newnan Advising Center for a walk-in advising event to discuss Winter 2020 CGIS applications.

Before you leave for the summer, come and find out how studying abroad can fit into your degree plan, learn about scholarships and financial aid, and more!

Popcorn & punch will be provided!

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Meeting Wed, 10 Apr 2019 11:21:24 -0400 2019-04-17T13:00:00-04:00 2019-04-17T16:00:00-04:00 Weiser Hall Center for Global and Intercultural Study Meeting PHOTO
DCMB Seminar || Can cancer cells "engineer" regulatory pathways? (April 17, 2019 4:00pm) https://events.umich.edu/event/62789 62789-15466655@events.umich.edu Event Begins: Wednesday, April 17, 2019 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract: Over the past few years, small non-coding RNAs (smRNAs) have emerged as major regulators of metastatic progression. While micro-RNAs were among the first characterized post-transcriptional regulators of metastasis, we have now demonstrated that other annotated smRNAs, such as tRNAs and tRNA fragments, also impact metastatic progression. In their capacity as master regulators of gene expression, smRNAs play a major role in development, normal cell physiology, and homeostasis. However, they are often co-opted by cancer cells to help reprogram their gene expression landscape as the disease progresses. Our group has recently discovered a new class of small RNAs, which we have named orphan non-coding RNAs or oncRNAs [Fish et al, Nature Med 2018], that are largely undetected in normal cells and tissues and emerge as a consequence of cellular transformation. Because they were not previously annotated, oncRNAs had gone unnoticed in prior studies by us and others that were instead focused on quantitative changes in the expression of common smRNA regulators, such as miRNAs and tRNA fragments. These oncRNAs, which we first identified in breast cancer, provide a pool of new biomolecules with regulatory potential that can be subsequently adopted by tumor cells to carry out new oncogenic functions. We have demonstrated that breast cancer cells adopt a specific oncRNA (named T3p) to regulate the expression of two key promoters of metastasis. This finding demonstrates that oncRNAs can serve as potential building blocks for “cancer-emergent” regulatory pathways. We posit that oncRNA-mediated regulatory interactions add a new layer of complexity to gene regulation in cancers.

3:30 pm to 4:00 pm - Light refreshments in Atrium Hall, Palmer Commons
4:00 pm to 5:00 pm - Lecture in Forum Hall, Palmer Commons

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Lecture / Discussion Tue, 02 Apr 2019 09:22:50 -0400 2019-04-17T16:00:00-04:00 2019-04-17T17:00:00-04:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
Radical reactions for control freaks: New synthetic methods involving aryl radicals and strong C–F bonds (April 17, 2019 4:00pm) https://events.umich.edu/event/58115 58115-14426735@events.umich.edu Event Begins: Wednesday, April 17, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Over the past few years, our group has utilized photoredox catalysis to access highly-reactive radical intermediates. Our broader aims are centered on utilizing these intermediates to deliver structural motifs that are commonly found in drugs and agrochemicals. This lecture will include recent findings that have enabled us to overcome inherent difficulties in aryl radical reactivity, allowing for the development of highly chemoselective and switchable processes. Importantly, these studies have enabled the development of many other selective processes, including strategies for peptide functionalization and activation of very strong C–F bonds.











Nathan Jui (Emory University)

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Other Wed, 17 Apr 2019 18:15:25 -0400 2019-04-17T16:00:00-04:00 2019-04-17T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Super-Resolution Microscopy Made Simple (April 18, 2019 4:00pm) https://events.umich.edu/event/52763 52763-13023548@events.umich.edu Event Begins: Thursday, April 18, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


The Vaughan group develops new chemical tools for high resolution fluorescence microscopy and uses these tools, along with established ones, to understand the organization of biological systems with rich molecular detail. On the tool development side, we are synthesizing new fluorescent probes, creating new methods for tissue expansion and clearing, and developing assays to understand the organization of the genome. On the application side, we have partnered with biologists and pathologists to study the cytoskeleton, the organization of mouse and human kidney, and immune cell development. In my talk, I will discuss our recent work on the development and application of chemical tools for biological imaging.















Joshua Vaughan (University of Washington)

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Other Thu, 18 Apr 2019 18:15:23 -0400 2019-04-18T16:00:00-04:00 2019-04-18T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
U-M Biological Station: Student Orientation/Info Session (April 18, 2019 4:00pm) https://events.umich.edu/event/61862 61862-15223786@events.umich.edu Event Begins: Thursday, April 18, 2019 4:00pm
Location: Dana Natural Resources Building
Organized By: University of Michigan Biological Station

Admitted students for spring/summer 2019: Come for important information, dates, requirements, packing lists, etc. Prospective students: Come see what you'll be missing if you don't register! It's not too late :-).

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Rally / Mass Meeting Tue, 02 Apr 2019 15:20:00 -0400 2019-04-18T16:00:00-04:00 2019-04-18T17:00:00-04:00 Dana Natural Resources Building University of Michigan Biological Station Rally / Mass Meeting Peaceful sunrise on Douglas Lake.
Thesis Defense: "Development of Methods for Introducing Fluorine Groups to Small Molecules" (April 19, 2019 10:00am) https://events.umich.edu/event/62960 62960-15522187@events.umich.edu Event Begins: Friday, April 19, 2019 10:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Devin Ferguson (Advisor: Prof. Melanie Sanford)

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Other Fri, 19 Apr 2019 18:15:19 -0400 2019-04-19T10:00:00-04:00 2019-04-19T11:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Materials Chemistry Students 3rd Year Research Seminars (April 19, 2019 12:00pm) https://events.umich.edu/event/62976 62976-15528487@events.umich.edu Event Begins: Friday, April 19, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Nathaniel Hardin, Jessi Wilson

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Other Fri, 19 Apr 2019 18:15:19 -0400 2019-04-19T12:00:00-04:00 2019-04-19T13:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: "“Development of the Silicon Photonic Microring Resonator Platform with Applications for the Detection of Nucleic Acids and Other Biopolymers” (April 19, 2019 1:00pm) https://events.umich.edu/event/62062 62062-15284705@events.umich.edu Event Begins: Friday, April 19, 2019 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Maria Cardenosa Rubio (Thesis Advisor: Prof. Ryan C. Bailey)

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Other Fri, 19 Apr 2019 18:15:19 -0400 2019-04-19T13:00:00-04:00 2019-04-19T14:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
TBA (April 19, 2019 4:00pm) https://events.umich.edu/event/62971 62971-15526387@events.umich.edu Event Begins: Friday, April 19, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Conventional macromolecular crystallographic refinement relies on stereochemistry restraints and a rudimentary energy functional to ensure the correct geometry of the model of the macromolecule, along with any bound ligand(s), within the experimental, X-ray density. Traditionally, these highly approximate methods lack explicit, rigorous terms for electrostatics, polarization, dispersion, hydrogen bonds, and other interactions, and they often rely on pre-determined parameters to capture the a priori understanding of the structure. In order to address this deficiency and capture a more complete understanding of the structure, we have developed a fully automated approach for macromolecular refinement based on a two layer, QM/MM (ONIOM) scheme implemented within our DivCon Suite which has been "plugged in" to two mainstream crystallographic packages: PHENIX[1] and BUSTER. This implementation consists of one or more "region layer(s)" characterized using linear-scaling, semi-empirical quantum mechanics, coupled with a "system layer" encompassing the rest of the protein described with a molecular mechanics functional[2].
Armed with a more accurate tool, we not only gain a better understanding of overall protein:ligand structure, but we can also use X-ray data to correctly determine active site tautomer/protomer states[3] and water site locations.
In this talk, we will discuss these methods and explore their impact in the context of binding affinity prediction and structure-based drug discovery.

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Workshop / Seminar Tue, 09 Apr 2019 08:51:59 -0400 2019-04-19T16:00:00-04:00 2019-04-19T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
New methods and strategies in the synthesis of natural products (April 22, 2019 4:00pm) https://events.umich.edu/event/61881 61881-15225983@events.umich.edu Event Begins: Monday, April 22, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

New methods and strategies in the synthesis of terpenoid and polyketide natural products will be discussed.




Sergey Pronin (UC Irvine)

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Other Mon, 22 Apr 2019 18:15:12 -0400 2019-04-22T16:00:00-04:00 2019-04-22T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Chemical Regulation of Functional RNAs (April 23, 2019 4:00pm) https://events.umich.edu/event/55268 55268-13711531@events.umich.edu Event Begins: Tuesday, April 23, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

We study the mechanisms of specificity and regulation of enzymes that act on RNA. We identified the molecular basis for how a small molecule, heme, affects microRNA processing enzyme Drosha. We show that heme acts as a signaling factor to switch on processing of a subset of microRNAs. Other chemicals such as S-adenosylmethioinine, and transfer of its methyl group to RNA, can also have a big role in RNA-mediated gene regulation. We show the mechanistic details of how RNA methylation is accomplished, using crystal structures and biochemical studies.








Yunsun Nam (UT Southwestern Medical Center)

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Other Tue, 23 Apr 2019 18:15:14 -0400 2019-04-23T16:00:00-04:00 2019-04-23T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Biophysics Symposium (April 24, 2019 8:00am) https://events.umich.edu/event/62917 62917-15494569@events.umich.edu Event Begins: Wednesday, April 24, 2019 8:00am
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Protein-protein interactions among Bcl-2 family proteins regulate apoptosis. Anti-apoptotic members of the family, including Bcl-2, Bcl-xL, Bcl-w, Mcl-1, and Bfl-1, sequester pro-apoptotic family members by binding tightly to an amphipathic alpha helix within them, blocking pro-death functions. Through this mechanism, overexpression of the anti-apoptotic proteins is implicated in oncogenesis and resistance to chemotherapy. Tight-binding and selective inhibitors of Bcl-2 family proteins can be used to diagnose the Bcl-2 dependencies of cancer cells and may be developed as therapeutics. The challenge of designing peptides that function as high-affinity and selective inhibitors of specific Bcl-2 family proteins poses a fundamental, challenging problem in protein engineering and a good opportunity to study principles of protein-peptide recognition. I will describe features of Bcl-2 family protein interactions and discuss approaches we have developed that integrate computational structure-based modeling with high-throughput screening to generate peptide-based inhibitors.

Register here: https://sites.lsa.umich.edu/biophysics-symposium/2019-biophysics-symposium-registration/

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Conference / Symposium Wed, 10 Apr 2019 12:42:37 -0400 2019-04-24T08:00:00-04:00 2019-04-24T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Conference / Symposium Chemistry Dow Lab
Materials Chemistry Students 3rd Year Research Seminars (April 24, 2019 1:15pm) https://events.umich.edu/event/62993 62993-15530603@events.umich.edu Event Begins: Wednesday, April 24, 2019 1:15pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




William Dean, Matthew Hannigan, Quintin Cheek, Samuel Michaud, Jinhee Kim

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Other Wed, 24 Apr 2019 18:15:12 -0400 2019-04-24T13:15:00-04:00 2019-04-24T16:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
The Riddler: Exploring the Structure-Function-Stability Relationship in Organic Electronic Materials (April 25, 2019 1:00pm) https://events.umich.edu/event/62251 62251-15337487@events.umich.edu Event Begins: Thursday, April 25, 2019 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Coming soon ....








Jeanne Pemberton (University of Arizona)

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Other Thu, 25 Apr 2019 18:15:12 -0400 2019-04-25T13:00:00-04:00 2019-04-25T14:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: “Synthesis and Spectroscopic Characterization of Ferric Heme-Thiolate Complexes and their Reactivity with NO as Models for Cytochrome P450 Nitric Oxide Reductase” (April 25, 2019 1:00pm) https://events.umich.edu/event/63050 63050-15539038@events.umich.edu Event Begins: Thursday, April 25, 2019 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Andrew P. Hunt (Advisor: Prof. Nicolai Lehnert)

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Other Thu, 25 Apr 2019 18:15:12 -0400 2019-04-25T13:00:00-04:00 2019-04-25T14:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
TBA (April 25, 2019 4:00pm) https://events.umich.edu/event/59508 59508-14748067@events.umich.edu Event Begins: Thursday, April 25, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry














Aniruddha Ray (University of Toledo)

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Other Fri, 29 Mar 2019 06:15:39 -0400 2019-04-25T16:00:00-04:00 2019-04-25T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: "New Reactivity Modes between Carbonyls and Olefins: Catalytic Carbonyl-Olefin Metathesis and Oxygen Atom Transfer" (April 26, 2019 12:00pm) https://events.umich.edu/event/62962 62962-15522189@events.umich.edu Event Begins: Friday, April 26, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Rebecca Watson (Advisor: Prof. Corinna Schindler)

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Other Fri, 26 Apr 2019 18:15:13 -0400 2019-04-26T12:00:00-04:00 2019-04-26T13:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: "Automated Reaction Discovery to Understand Chemical Reactivity" (April 26, 2019 3:00pm) https://events.umich.edu/event/62961 62961-15522188@events.umich.edu Event Begins: Friday, April 26, 2019 3:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Amanda Dewyer (Advisor: Prof. Paul Zimmerman)

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Other Fri, 26 Apr 2019 18:15:12 -0400 2019-04-26T15:00:00-04:00 2019-04-26T16:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
RNA Innovation Seminar, Theme: Cell Biology (April 29, 2019 3:00pm) https://events.umich.edu/event/59775 59775-14786526@events.umich.edu Event Begins: Monday, April 29, 2019 3:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

“A NOVA1-PTBP1-PTBP2 Axis in Telomerase Alternative Splicing”
Mohammed Sayed, Ph.D.
postdoctoral fellow from the Andrew Ludlow Integrative Molecular Genetics Laboratory
~and~
“Epigenetic hijacking of developmental HOX programs promotes Ewing sarcoma tumorigenesis”
April Apfelbaum
Ph.D. candidate from the Beth Lawlor lab

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Lecture / Discussion Tue, 16 Apr 2019 15:53:40 -0400 2019-04-29T15:00:00-04:00 2019-04-29T16:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion flyer
Philicities, Fugalities, and Equilibrium Constants: (April 29, 2019 4:00pm) https://events.umich.edu/event/52990 52990-13170378@events.umich.edu Event Begins: Monday, April 29, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our understanding of polar organic reactivity is based on relationships between rate and equilibrium constants. Thus, strong bases are generally considered to be good nucleophiles as well as poor nucleofuges. Though exceptions from this general rule have long been known, a systematic analysis has been problematic, because rate constants for the reactions of nucleophiles with C-centered electrophiles have often been correlated with Brønsted basicities (i. e., affinities towards the proton). For that reason, the origin of deviations from Brønsted correlations could often not unambiguously be assigned.



In the last two decades, we have created comprehensive nucleophilicity,1 nucleofugality,2 and Lewis basicity scales3 by using differently substituted benzhydrylium ions with widely variable reactivity but equal steric demand as reference electrophiles,1 electrofuges,2 and Lewis acids.3 Relationships between these kinetic and thermodynamic parameters will be discussed with emphasis on examples where the commonly assumed proportionalities break down.4
I will discuss the origin of several counterintuitive phenomena, e.g. why strong nucleophiles can also be good nucleofuges, and why weak nucleophiles sometimes substitute strong nucleophiles in SN2 reactions. It will be shown that solvolysis rate constants of alkyl bromides and chlorides, but not of carboxylates provide accurate information about thermodynamic stabilities (more precise: Lewis acidities) of carbocations. Eventually it will be discussed why carbocations, which are formed slowly in SN1 reactions are not always good electrophiles.5 The role of intrinsic barriers for controlling organic reactivity will be analyzed.

1. (a) H. Mayr, A. R. Ofial, J. Phys. Org. Chem. 2008, 21, 584
(b) Data base: http://www.cup.uni-muenchen.de/oc/mayr/DBintro.html.
2. Streidl, N.; Denegri, B.; Kronja, O.; Mayr, H.; Acc. Chem. Res. 2010, 43, 1537-1549.
3. Mayr, H.; Ammer, J.; Baidya, M.; Maji, B.; Nigst, T. A.; Ofial, A. R.; Singer, T.; J. Am. Chem. Soc. 2015, 137, 2580-2599.
4. Mayr, H.; Ofial, A. R.; Acc. Chem. Res. 2016, 49, 952-965.
5. Byrne, P.A.; Kobayashi, S.; Würthwein, E.-U.; Ammer, J.; Mayr H. J. Am. Chem. Soc. 2017, 139, 1499-1511.









Herbert Mayr (Ludwig-Maximilians-Universitaet Muenchen)

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Other Mon, 29 Apr 2019 18:15:08 -0400 2019-04-29T16:00:00-04:00 2019-04-29T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Chemical Approaches to Interrogating the Transcriptome (April 30, 2019 4:00pm) https://events.umich.edu/event/61059 61059-15027186@events.umich.edu Event Begins: Tuesday, April 30, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


Although once regarded as a transient messenger of genetic information, novel and exciting roles played by RNA inside cells continue to be revealed. Nevertheless, as the list of cataloged RNAs expands there is a parallel lag in our understanding of the mechanistic basis of many RNA functions. This is in many ways due to a dearth of precise biochemical methods to understand RNA expression, structure, and function. Within this seminar I will detail our lab’s efforts to bring the power of chemistry to bare on these challenges, with particular focus on developing novel chemical reactions to measure RNA structure and chemical genetic approaches to assay RNA expression in a cell-specific manner.











Robert Spitale (University of California Irvine)

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Other Tue, 30 Apr 2019 18:15:07 -0400 2019-04-30T16:00:00-04:00 2019-04-30T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: “New Strategies for Carbonyl-Olefin Metathesis” (May 1, 2019 11:00am) https://events.umich.edu/event/62812 62812-15470942@events.umich.edu Event Begins: Wednesday, May 1, 2019 11:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Jacob Ludwig (Advisor: Prof. Corinna Schindler)

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Other Wed, 01 May 2019 18:15:14 -0400 2019-05-01T11:00:00-04:00 2019-05-01T12:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: Mechanistic studies on phosphoric acid-catalyzed acetalizations and development of acetal-containing ligands for transition metal catalysis" (May 2, 2019 10:00am) https://events.umich.edu/event/63019 63019-15536913@events.umich.edu Event Begins: Thursday, May 2, 2019 10:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Alonso J. Arguelles (Advisors: Pavel Nagorny & Paul Zimmerman)

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Other Thu, 02 May 2019 18:15:08 -0400 2019-05-02T10:00:00-04:00 2019-05-02T11:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Commencement Ceremony for Chemistry Majors (May 2, 2019 12:00pm) https://events.umich.edu/event/61232 61232-15054324@events.umich.edu Event Begins: Thursday, May 2, 2019 12:00pm
Location: Off Campus Location
Organized By: Department of Chemistry

RSVP to Chemistry Undergraduate Office , chemundergrad@umich.edu

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Ceremony / Service Tue, 30 Apr 2019 20:40:33 -0400 2019-05-02T12:00:00-04:00 2019-05-02T13:00:00-04:00 Off Campus Location Department of Chemistry Ceremony / Service mortar board decorated "now I am like this cylinder --graduated"
Thesis Defense: “The Development of Catalyzed Carbonyl-Olefin Metathesis and Oxygen Atom Transfer Reactions” (May 6, 2019 10:00am) https://events.umich.edu/event/62813 62813-15470943@events.umich.edu Event Begins: Monday, May 6, 2019 10:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Haley Albright (Advisor: Prof. Corinna Schindler)

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Other Mon, 06 May 2019 18:15:08 -0400 2019-05-06T10:00:00-04:00 2019-05-06T11:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Celgene Lecture Symposium (May 6, 2019 1:00pm) https://events.umich.edu/event/61858 61858-15223782@events.umich.edu Event Begins: Monday, May 6, 2019 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Oxidation and reduction reactions are among the most important and frequently executed processes in organic synthesis. However, our ability to manipulate the oxidation states of functional groups in complex settings with high efficiency, precision, and minimal waste remains in a largely nascent stage. Owing to its many distinct characteristics, electrochemistry represents an attractive approach to meet the prevailing trends in organic synthesis. In particular, electrocatalysis—a process that integrates electrochemistry and small-molecule catalysis—has the potential to substantially improve the scope of synthetic electrochemistry and provide a wide range of useful transformations. Despite its attractive attributes and extensive applications in energy-related fields, electrocatalysis has been used only sparingly in synthetic organic chemistry. Toward this end, we developed a new catalytic approach that combines electrochemistry and redox-metal catalysis for the oxidative difunctionalization of alkenes to access a diverse array of vicinally functionalized structures. This presentation will detail our design principle underpinning the development of electrocatalytic alkene diazidation, dichlorination, halotrifluoromethylation, haloalkylation, and cyanophosphonylation.


Larry Hamann(Celgene) , Donna Huryn(University of Pittsburgh) , Song Lin(Cornell University)

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Other Mon, 06 May 2019 18:15:07 -0400 2019-05-06T13:00:00-04:00 2019-05-06T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Video-rate AFM Workshop for Dynamic Imaging (May 7, 2019 9:00am) https://events.umich.edu/event/62944 62944-15520071@events.umich.edu Event Begins: Tuesday, May 7, 2019 9:00am
Location: Palmer Commons
Organized By: Center for RNA Biomedicine

This two-day workshop (May 7-8) and demo will present topics on fast atomic force microscopy (AFM) for dynamic cellular/biomolecular imaging and biophysical measurements, followed by a demo period for user-provided samples. See the attached flyer for additional information.

This event is sponsored by the Single Molecule Analysis in Real-Time (SMART) Center [http://singlemolecule.lsa.umich.edu/], a University of Michigan Biosciences Initiative Research Core [https://cores.research.umich.edu/core/single-molecule-analysis-in-real-time-smart-center/] of the Center for RNA Biomedicine [https://www.umichrna.org/]; and Oxford Instruments.
PDF Flyer: https://www.umichrna.org/wp-content/uploads/2019/04/University-of-Michigan-AFM-Workshop.pdf

Register:
http://afm.oxinst.com/UMichiganAFM

Contact:
Drew Griffin, drew.griffin@oxinst.com
Damon Hoff, hoffj@umich.edu

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Workshop / Seminar Wed, 17 Apr 2019 13:50:13 -0400 2019-05-07T09:00:00-04:00 2019-05-07T15:00:00-04:00 Palmer Commons Center for RNA Biomedicine Workshop / Seminar flyer
"Elucidating RNA structure and the molecular recognition properties of multi-domain enzymes: nucleic acid binding interactions at the chromatin interface" (May 7, 2019 4:00pm) https://events.umich.edu/event/55269 55269-13711532@events.umich.edu Event Begins: Tuesday, May 7, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry
















Nick Reiter (Marquette University)

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Other Tue, 07 May 2019 18:15:08 -0400 2019-05-07T16:00:00-04:00 2019-05-07T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: "Methods and Informatics to Analyze Intact Protein Sequence and Structure by Ion Mobility-Mass Spectrometry (May 8, 2019 12:00pm) https://events.umich.edu/event/62963 62963-15522190@events.umich.edu Event Begins: Wednesday, May 8, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Daniel Polasky (Advisor: Brandon Ruotolo)

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Auditions Wed, 08 May 2019 18:15:08 -0400 2019-05-08T12:00:00-04:00 2019-05-08T13:00:00-04:00 Chemistry Dow Lab Department of Chemistry Auditions Chemistry Dow Lab
Thesis Defense: “Microfluidic Technologies for Bioanalytical Chemistry: Advancing Epigenetic Profiling via Chromatin Immunoprecipitation in Droplets” (May 9, 2019 2:00pm) https://events.umich.edu/event/63207 63207-15589332@events.umich.edu Event Begins: Thursday, May 9, 2019 2:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Steven R. Doonan (Advisor: Prof. Ryan C. Bailey)

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Other Thu, 09 May 2019 18:15:10 -0400 2019-05-09T14:00:00-04:00 2019-05-09T15:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Improving Efficiency Through Catalytic and Multicatalytic Reactions (May 9, 2019 4:00pm) https://events.umich.edu/event/58954 58954-14623975@events.umich.edu Event Begins: Thursday, May 9, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry














Mark Lautens (U Toronto)

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Other Thu, 09 May 2019 18:15:10 -0400 2019-05-09T16:00:00-04:00 2019-05-09T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Thesis Defense: "Photo- and Electrochemical Methods for Biomass Valorization" (May 10, 2019 10:00am) https://events.umich.edu/event/63367 63367-15661293@events.umich.edu Event Begins: Friday, May 10, 2019 10:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Gabriel Magallanes (Thesis Advisor: Prof. Corey Stephenson)

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Other Fri, 10 May 2019 18:15:11 -0400 2019-05-10T10:00:00-04:00 2019-05-10T11:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Cayman Symposium (May 16, 2019 10:00am) https://events.umich.edu/event/63616 63616-15816687@events.umich.edu Event Begins: Thursday, May 16, 2019 10:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




















Daniel Nomura(UC Berkeley) , Dustin Maly(U. Washington)

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Other Thu, 16 May 2019 18:15:14 -0400 2019-05-16T10:00:00-04:00 2019-05-16T16:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Reinventing Drug Discovery through Chemical Biology (May 16, 2019 10:00am) https://events.umich.edu/event/63351 63351-15653094@events.umich.edu Event Begins: Thursday, May 16, 2019 10:00am
Location: Chemistry Dow Lab
Organized By: U-M College of Pharmacy

Sponsored by Cayman Chemical

Keynote lectures from Profs. Dusty Maly (Univ. of Washington; http://depts.washington.edu/malylab/wordpress/) and Daniel Nomura (UC Berkeley; http://nomuraresearchgroup.com).

Additional lectures from U-M faculty Profs. Matt Soellner, Amanda Garner, Nouri Neamati and Jolanta Grembecka.

A poster session and catered lunch will be held from 12-1:30 PM.

Two poster presenters will be invited to give a short talk about their research.

Please RSVP by May 9.

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Lecture / Discussion Wed, 24 Apr 2019 15:13:38 -0400 2019-05-16T10:00:00-04:00 2019-05-16T16:00:00-04:00 Chemistry Dow Lab U-M College of Pharmacy Lecture / Discussion Chemistry Dow Lab
Scientific publishing from the inside out (May 17, 2019 12:00pm) https://events.umich.edu/event/63182 63182-15587256@events.umich.edu Event Begins: Friday, May 17, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

For over 130 years, Science Magazine has presented a weekly selection of the finest research across the full spectrum of scientific disciplines. Our goal remains to keep scientists well-informed about important developments within and also beyond their own fields of research, and to encourage collaborative thinking. This talk will discuss how the staff at Science engages the research community all over the world to determine which papers to publish, and also how we envision maintaining and enhancing our value to the community in the rapidly evolving publication landscape.









Jake Yeston (Science)

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Other Fri, 17 May 2019 18:15:10 -0400 2019-05-17T12:00:00-04:00 2019-05-17T13:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
RNA Innovation Seminar, Theme: Genetics (May 20, 2019 3:00pm) https://events.umich.edu/event/59776 59776-14786527@events.umich.edu Event Begins: Monday, May 20, 2019 3:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Andrew Liu, Ph.D. candidate
Hyun Kang lab
"Meta-prediction of gene expression levels from genotypes across multiple tissues and datasets"

~and~

Marissa Cloutier, Ph.D.,
postdoctoral fellow
Sundeep Kalantry Lab
"Maternal Control of Paternal X-inactivation"

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Lecture / Discussion Mon, 13 May 2019 12:18:48 -0400 2019-05-20T15:00:00-04:00 2019-05-20T16:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion flyer
19th Annual James V. Neel Lecture in Human Genetics (May 21, 2019 2:00pm) https://events.umich.edu/event/63339 63339-15644918@events.umich.edu Event Begins: Tuesday, May 21, 2019 2:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Department of Human Genetics

The James V. Neel Lecture will take place Tuesday, May 21, 2019 at 2:00 pm in BSRB Kahn Auditorium. The speaker is Dr. James Lupski, from Baylor College of Medicine in Houston, Texas. The Lecture honors James V. Neel, former Chair of the Department of Human Genetics for over 25 years, and a pioneer in the field of genetics.

Dr. Lupski is The Cullen Foundation Endowed Chair in Molecular and Human Genetics and Professor of Pediatrics. He received his initial scientific training at the Cold Spring Harbor Laboratory as an Undergraduate Research Participant (URP). At New York University, he received his undergraduate degree in chemistry and biology (1979) and earned a doctorate in biochemistry and molecular biology, and an M.D. in 1985. In 1986, he moved to Houston, Texas for clinical training in pediatrics (1986-1989) and medical genetics (1989-1992) and then established his own laboratory at Baylor College of Medicine where he remains, and as of 1995, as the Cullen Professor.

Dr. Lupski's research focuses on understanding mutational mechanisms and linking specific mutations and genes to human disease. Dr. Lupski started his laboratory at Baylor College of Medicine in 1989, where he still resides. His most significant contributions to genomics are centered around conceptualizing and understanding the mechanisms underlying genomic disorders. This is seen through his studies of Charcot-Marie Tooth (CMT) disease - specifically, duplication of the CMT1A gene. In 1991, Dr. Lupski showed that CMT1A copy number variation (CNV) and gene dosage are causes of CMT-related peripheral nerve dysfunction. In 2014, he and his colleagues found that the presence of three copies of CMT1A on one chromosome 17, a phenomenon known as triplication, causes a more severe form of CMT. His group was also the first to describe non-allelic homologous recombination as a mechanism for CNV formation and chromosomal aberrations. These discoveries, with parallels and potential applications to other genomic disorders, furthered scientific understanding of the relationships between genetic variants and disease outcomes, helped define the field of genomic medicine, and are paving the way for precision medicine.

In 2018, Dr. Lupski was named as the recipient of the Victor A. McKusick Leadership Award from the American Society of Human Genetics. This award recognizes individuals whose professional achievements have fostered and enriched the development of human genetics as well as its assimilation into the broader context of science, medicine, and health.

Following the lecture, there will be a poster session/reception. For more information, contact the Department of Human Genetics, 734-647-3149.

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Lecture / Discussion Tue, 23 Apr 2019 17:52:13 -0400 2019-05-21T14:00:00-04:00 2019-05-21T17:00:00-04:00 Taubman Biomedical Science Research Building Department of Human Genetics Lecture / Discussion
Engaging Esters, Aldehydes, and Alcohols in Ni-Catalyzed Couplings: A High Throughput Approach to Reaction Discovery (May 24, 2019 12:00pm) https://events.umich.edu/event/62063 62063-15284706@events.umich.edu Event Begins: Friday, May 24, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Catalytic cross-coupling reactions that unite simple organic building blocks continue to increase in scope, utility, and frequency of use. Progress in this field stems from improved mechanistic understanding, development of new catalysts, and identification of new functional groups that can be activated and engaged in cross-couplings and related transformations. In this seminar, strategies to incorporate esters, aldehydes, and alcohols into Ni-catalyzed C-C and C-N forming reactions will be discussed. The discovery process will also be detailed, including how a rational, mechanism-guided approach can act in synergy with high throughput experimentation techniques.




Stephen Newman (University of Ottawa)

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Other Thu, 09 May 2019 06:15:08 -0400 2019-05-24T12:00:00-04:00 2019-05-24T13:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Faculty candidate seminar - Department of Human Genetics and Center for RNA Biomedicine (May 30, 2019 10:00am) https://events.umich.edu/event/63798 63798-15881710@events.umich.edu Event Begins: Thursday, May 30, 2019 10:00am
Location: Buhl Res Cen for Human Genetics
Organized By: Center for RNA Biomedicine

"Spatiotemporal regulation of mRNA function in health and neurological disease"

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Lecture / Discussion Wed, 22 May 2019 13:43:58 -0400 2019-05-30T10:00:00-04:00 2019-05-30T11:00:00-04:00 Buhl Res Cen for Human Genetics Center for RNA Biomedicine Lecture / Discussion flyer
RNA Innovation Seminar, Theme: Biochemistry (June 3, 2019 3:00pm) https://events.umich.edu/event/59777 59777-14786528@events.umich.edu Event Begins: Monday, June 3, 2019 3:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

"Investigating the Coactivator Med25 - Activator Recognition Features" Nick Foster, Ph.D. candidate
Anna Mapp lab

~and~

"Local-to-global signal transduction at the core of the Mn2+ sensingriboswitch" Shiba Dandpat, Ph.D. candidate
Nils Walter lab

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Lecture / Discussion Thu, 23 May 2019 09:41:34 -0400 2019-06-03T15:00:00-04:00 2019-06-03T16:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion flyer
Department of Computational Medicine & Bioinformatics Seminar (June 6, 2019 3:30pm) https://events.umich.edu/event/63849 63849-15939550@events.umich.edu Event Begins: Thursday, June 6, 2019 3:30pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Protein synthesis is an indispensable process which accounts for a large proportion of the energetic resources of any living cells. Therefore, translational regulation must be tightly controlled. Such regulation is critical for protein biogenesis, folding, trafficking and degradation under stable and changing conditions. I will focus on the importance of hidden evolutionary signatures within the coding region of proteins that govern translational efficiency and dominate proteostasis in health and disease. I will discuss the notion of tRNA adaptation index (tAI) as an indirect measure for translation elongation efficiency. Specifically, I will show that proteins which must be localized to specific sites and organelles in cells evolved to support their optimal translation elongation rate. A link between an evolutionary signature within mRNAs and efficient management of protein production will be illustrated for the case of synaptic proteins and their family members. Neuronal communication is governed by the coordinated action of the synapse. In all organisms having a nerve system, the synapses are signified by the abundance of ion channels, cytoskeletal elements, ligand binding receptors, and secreted proteins. As such, the proteins composition is a showcase for an extreme demand of translational control. In the last part of the talk, I will extend the concept of translation regulation by illustrating the robustness of the translational machinery in view of post-translational regulation of miRNA in cells. I will present COMICS as a simulator that predict the global cell response to miRNA alterations, and illustrate the immunity of the translation apparatus to miRNA fluctuations. In summary, I will show that evolutionarily conserved design principles while often hidden are a strong determinant in the cell homeostasis in health and disease.

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Lecture / Discussion Wed, 29 May 2019 13:40:25 -0400 2019-06-06T15:30:00-04:00 2019-06-06T17:00:00-04:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
RNA Innovation Seminar (June 10, 2019 3:00pm) https://events.umich.edu/event/59778 59778-14786529@events.umich.edu Event Begins: Monday, June 10, 2019 3:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

1.) "The Center for Structural Biology: Now and in the Future plus a sneak peek at ZAP"
Jeanne Stuckey Ph.D.
Associate Professor
Life Sciences Institute

and

2.) "Matrin 3 toxicity and regulation in amyotrophic lateral sclerosis and frontotemporal dementia models"
Ahmed Malik, MSTP fellow
Sami Barmada lab

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Lecture / Discussion Wed, 05 Jun 2019 11:16:40 -0400 2019-06-10T15:00:00-04:00 2019-06-10T16:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion flyer
TBA (June 14, 2019 1:00pm) https://events.umich.edu/event/62814 62814-15470944@events.umich.edu Event Begins: Friday, June 14, 2019 1:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Due to the highly active radical intermediate, the organic transformation via radical pathway have been extensively studied. However, the selective control of radical intermediate is extremely challenging, which significantly retards the success of highly selective radical reaction, specially for the enantioselective version. Recently, Our group recently reveals that the stereoselective control of radical could be achieved by using copper catalyst, and a series of enantioselective difunctionalization of alkenes have been explored by using bisoxazoline (Box)/Cu(I) catalytic system. In these studies, a benzylic radical intermediate was involved in the catalytic cycles, which can be enantioselectively traped by (Box)/CuII intermediate to produce enantiomerically enriched products. In this talk, I'd like to introduced our recent progress in the asymmetric oxidative functionalization of C-H bonds, including benzylic and allylic C-H bonds, wherein copper catalyst plays important roles on the both site- and enantioselectivity.












Chaozhong Li(Shanghai Institute of Organic Chemistry) , Guosheng Liu(Shanghai Institute of Organic Chemistry)

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Other Fri, 14 Jun 2019 18:15:14 -0400 2019-06-14T13:00:00-04:00 2019-06-14T15:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Book club- Becoming by Michelle Obama Part I: Becoming me (Chap 1-8) (June 25, 2019 6:00pm) https://events.umich.edu/event/63964 63964-16041377@events.umich.edu Event Begins: Tuesday, June 25, 2019 6:00pm
Location:
Organized By: MUSES

This summer MUSES is having a book club featuring "Becoming" by Michelle Obama. Becoming was the #1 best-selling book in 2018 totaling 3.4 million copies. Come join us as we discuss the journey of the first African American first lady of the United States.

The book club will be divided into 3 parts:

Becoming me (Chap 1-8): June 25th, Duderstadt 1120D Conf Rm D
Becoming us (Chap 9-18): July 30th, Duderstadt 1120D Conf Rm D
Become more (Chap 19-24): Aug 27th, Duderstadt 1120D Conf Rm D

Food will be provided, Please RSVP here for June 25th, so we can have enough food
If you need a book or have any other question, please contact us at umichmuses@gmail.com

Best,
MUSES Committee

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Meeting Tue, 11 Jun 2019 09:09:36 -0400 2019-06-25T18:00:00-04:00 2019-06-25T19:30:00-04:00 MUSES Meeting
"Purification and surface chemistry of colloidal nanocrystals and nanowires " (June 27, 2019 4:00pm) https://events.umich.edu/event/63769 63769-15873579@events.umich.edu Event Begins: Thursday, June 27, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry






Andrew Greytak

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Other Thu, 27 Jun 2019 18:15:14 -0400 2019-06-27T16:00:00-04:00 2019-06-27T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Summer Omics Learning Seminar Series - Co-Sponsored by the M-LEEaD Omics, Bioinformatics Core, and the Department of Computational Medicine & Bioinformatics (July 9, 2019 11:00am) https://events.umich.edu/event/63537 63537-15782025@events.umich.edu Event Begins: Tuesday, July 9, 2019 11:00am
Location: School of Public Health Bldg I and Crossroads and Tower
Organized By: DCMB Seminar Series

Adductomics

"Strategies and approaches for human biomonitoring of environmental and dietary carcinogens"

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Lecture / Discussion Fri, 10 May 2019 11:56:21 -0400 2019-07-09T11:00:00-04:00 2019-07-09T12:00:00-04:00 School of Public Health Bldg I and Crossroads and Tower DCMB Seminar Series Lecture / Discussion School of Public Health Bldg I and Crossroads and Tower
RSC Meet the Editor: Deconstructing Reaction Coordinates for Ultrafast Excited-state Dynamics: Using Coherence to Inform Synthetic Design (July 11, 2019 11:30am) https://events.umich.edu/event/63770 63770-15873580@events.umich.edu Event Begins: Thursday, July 11, 2019 11:30am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Jennifer Lee(Royal Society of Chemistry Worldwide (US) Inc.) , James McCusker

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Other Thu, 11 Jul 2019 18:15:15 -0400 2019-07-11T11:30:00-04:00 2019-07-11T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Summer Omics Learning Seminar Series - Co-Sponsored by the M-LEEaD Omics, Bioinformatics Core, and the Department of Computational Medicine and Bioinformatics (July 23, 2019 11:00am) https://events.umich.edu/event/63539 63539-15782027@events.umich.edu Event Begins: Tuesday, July 23, 2019 11:00am
Location: Palmer Commons
Organized By: DCMB Seminar Series

Genomics

"The Michigan Genomics Initiative: An In-House Integrated Data Frame to Conduct Precision Health Queries"

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Lecture / Discussion Fri, 10 May 2019 11:59:55 -0400 2019-07-23T11:00:00-04:00 2019-07-23T12:00:00-04:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
Book Club - Becoming by Michelle Obama Part 2: Becoming us (Chap 9-18) (July 30, 2019 6:00pm) https://events.umich.edu/event/64488 64488-16372918@events.umich.edu Event Begins: Tuesday, July 30, 2019 6:00pm
Location: Duderstadt Center
Organized By: MUSES

We will continue our book club featuring "Becoming" by Michelle Obama. Becoming was the #1 best-selling book in 2018 totaling 3.4 million copies. Come join us as we discuss the journey of the first African American first lady of the United States.

We already explored Becoming me (Chap 1-8) on June 25th.

Following, we will explore:
Becoming us (Chap 9-18): July 30th, at 6pm, Duderstadt 1120D Conf Rm D
Become more (Chap 19-24): Aug 27th, at 6pm, Duderstadt 1120D Conf Rm D

If you would like to join us on July 30th, at 6 pm. Please, RSVP below so we can have enough food.
https://forms.gle/4HhPTKSnUPqUFdaL8

If you need a book or have any other questions, please contact us at umichmuses@gmail.com

Best,
MUSES Committee

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Meeting Mon, 22 Jul 2019 14:42:40 -0400 2019-07-30T18:00:00-04:00 2019-07-30T19:30:00-04:00 Duderstadt Center MUSES Meeting Duderstadt Center
U-M Ideas Lab: Informational Webinar on Predicting Human Performance (July 31, 2019 11:00am) https://events.umich.edu/event/64096 64096-16147464@events.umich.edu Event Begins: Wednesday, July 31, 2019 11:00am
Location: Michigan League
Organized By: Biosciences Initiative

Attend this webinar to learn more about the 2019 Biosciences Initiative U-M Ideas Lab: Predicting Human Performance.

Experts will:
- present background surrounding the Ideas Lab
- explore the topic in depth
- answer questions live from the audience

Questions may be sent ahead of time to biosciences@umich.edu.
Registration for the webinar: https://zoom.us/meeting/register/e93ed8dbfacf569acde7dc3c8da9331e
On-line attendance- please register yourself and utilize your individual link for the meeting.
In-person attendance- you may register on-line or when you arrive.

About U-M Ideas Lab:
The Biosciences Initiative U-M Ideas Lab is your chance to pursue high-risk, high-reward, creative ideas and solutions to broad biosciences challenges alongside colleagues with diverse areas of expertise. Use this interactive think tank funding opportunity to pursue innovative research while still focusing on your current program and other duties.

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Workshop / Seminar Fri, 12 Jul 2019 15:01:40 -0400 2019-07-31T11:00:00-04:00 2019-07-31T12:00:00-04:00 Michigan League Biosciences Initiative Workshop / Seminar Ideas Lab Banner
ALUM|NUM :: Alumni-Grad Networking, Graduate Awards Ceremony, Undergrad Poster Session & Reception (August 1, 2019 12:00pm) https://events.umich.edu/event/63725 63725-15833060@events.umich.edu Event Begins: Thursday, August 1, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

All alumni are welcome to come back to Michigan to join graduate students and postdocs for workshops on career, as well as the annual Graduate Student Awards ceremony. A reception follows the ceremony.
This annual event precedes the Karle Symposium on Friday, August 2.
Learn more on the ALUM|NUM and Karle websites.

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Reception / Open House Tue, 30 Jul 2019 13:35:11 -0400 2019-08-01T12:00:00-04:00 2019-08-01T18:30:00-04:00 Chemistry Dow Lab Department of Chemistry Reception / Open House save the date poster
URAN|UM Undergraduate Research Poster Session (August 1, 2019 4:00pm) https://events.umich.edu/event/64727 64727-16436921@events.umich.edu Event Begins: Thursday, August 1, 2019 4:00pm
Location:
Organized By: Department of Chemistry

Show your support for undergraduate researchers! Stop by the poster session that is part of our annual alumni networking event.

More than 30 undergraduate researchers from across Michigan and from our own department that will be presenting their research during a poster session

This event connects undergraduate chemistry departments across the midwest with current UM graduate students, postdoctoral fellows, faculty, and alumni and provides undergraduate students with a platform to share and celebrate their research.

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Conference / Symposium Tue, 30 Jul 2019 13:31:46 -0400 2019-08-01T16:00:00-04:00 2019-08-01T18:00:00-04:00 Department of Chemistry Conference / Symposium student wearing ppe holding test tube in lab setting
Karle Symposium (August 2, 2019 8:00am) https://events.umich.edu/event/63806 63806-15890342@events.umich.edu Event Begins: Friday, August 2, 2019 8:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Join us for the annual all-day showcase of research in the Department of Chemistry, organized and presented by our graduate students. The Symposium includes two keynote speakers, as well as a poster session and speakers from each Chemistry research cluster.
Registration opens June 10.
Get details at the Karle Symposium website: https://sites.lsa.umich.edu/karle-symposium/

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Workshop / Seminar Wed, 05 Jun 2019 11:11:17 -0400 2019-08-02T08:00:00-04:00 2019-08-02T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Workshop / Seminar logo for symposium
Karle Symposium (August 2, 2019 9:00am) https://events.umich.edu/event/62708 62708-15434126@events.umich.edu Event Begins: Friday, August 2, 2019 9:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry












Phil Baran

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Other Fri, 02 Aug 2019 18:15:18 -0400 2019-08-02T09:00:00-04:00 2019-08-02T18:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Electrochemical Reshaping of Living Tissues: Non-Invasive Surgical Modalities for Reshaping Cartilage and Cornea (August 8, 2019 4:00pm) https://events.umich.edu/event/64479 64479-16372908@events.umich.edu Event Begins: Thursday, August 8, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Michael Hill (Occidental College)

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Other Thu, 08 Aug 2019 18:15:24 -0400 2019-08-08T16:00:00-04:00 2019-08-08T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Application of Big Data in Medicine - Experience in China (August 22, 2019 12:00pm) https://events.umich.edu/event/65206 65206-16547477@events.umich.edu Event Begins: Thursday, August 22, 2019 12:00pm
Location: Taubman Library
Organized By: DCMB Seminar Series

Abstract
During the last few years, substantial enthusiasm has emerged towards the application of big data in medicine in China, in the expectation of resolving many existing challenges by combining powerful data resources with novel technologies. In the present talk, the data eco-system, status of current practice, existing challenges in the area will be discussed. In addition, the activities of National Institute of Health Data Science at Peking University will be briefly introduced.

Luxia Zhang, MD, MPH
Dr. Luxia Zhang is the professor in the renal division of Peking University First Hospital, and the Assistant Dean of National Institute of Health Data Science at Peking University. She obtained her M.D. degree at Peking University; and her MPH degree at Harvard School of Public Health.
Her research has focused on prevalence, risk factors, intervention and management of kidney disease in China. Her work provides first-hand information of kidney disease in China, and has gained wide attention internationally. During the last 3 years, she has initiated several projects based on big data and utilizing machine learning in the field of major non-communicable chronic diseases. Her studies have been published in top medical journals including the N Engl J Med, Lancet and BMJ. She was given 2016 Young Investigator Award by the Chinese Society of Nephrology. She is now the vice president of Beijing Young Nephrologists Society, and the editor of American Journal of Kidney Diseases.

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Lecture / Discussion Tue, 13 Aug 2019 11:38:17 -0400 2019-08-22T12:00:00-04:00 2019-08-22T14:00:00-04:00 Taubman Library DCMB Seminar Series Lecture / Discussion
CSIEUM - Workshop: Big Data in Pharma - Brainstorming a new 1-credit class (August 30, 2019 12:00pm) https://events.umich.edu/event/65519 65519-16607704@events.umich.edu Event Begins: Friday, August 30, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Marc Scanio (Abbvie)

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Other Fri, 30 Aug 2019 18:15:31 -0400 2019-08-30T12:00:00-04:00 2019-08-30T13:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Increasing Molecular Coverage in Complex Biological & Environmental Samples Using Ion Mobility-Mass Spectrometry (September 5, 2019 4:00pm) https://events.umich.edu/event/64170 64170-16179703@events.umich.edu Event Begins: Thursday, September 5, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


Mass spectrometry (MS)-based technologies are playing a growing role in the analysis of complex samples. Despite significant advances in MS technology, currently it is difficult to obtain measurements of both high throughput and high sensitivity for samples with great dynamic ranges such as biofluids and plant extracts. This problem ultimately results in the inability to effectively account for variation among sample conditions and/or biodiversity leading to inconsequential findings for samples which have great variation. To address this challenge, we have coupled an ion mobility separation (IMS) with MS to afford greatly improved measurement throughput, sensitivity, robustness, and quantitative capabilities for rapid analysis of complex samples. The benefits we have observed in omic studies of biological and environmental samples with IMS-MS will be summarized in this presentation.





Erin Baker (NC State)

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Other Thu, 05 Sep 2019 18:15:31 -0400 2019-09-05T16:00:00-04:00 2019-09-05T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Biophysics Talk Title: TBD (September 6, 2019 12:00pm) https://events.umich.edu/event/64280 64280-16274491@events.umich.edu Event Begins: Friday, September 6, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstracts: TBD

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Workshop / Seminar Wed, 10 Jul 2019 11:26:22 -0400 2019-09-06T12:00:00-04:00 2019-09-06T13:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
Words of Wisdom and Breakfast with Crystal Ashby (September 7, 2019 9:00am) https://events.umich.edu/event/65361 65361-16573561@events.umich.edu Event Begins: Saturday, September 7, 2019 9:00am
Location: Undergraduate Science Building
Organized By: MUSES

Crystal Ashby is a dynamic and innovative executive with a record of successes leading government and external affairs, legal and ethics and compliance organizations. She has held many executive roles during her career, including VP of BP Oil Company. For years she has helped Michigan female students with her wisdom and advice for a successful career and personal life. This is an opportunity you cannot miss.

If you would like, you can find more about Crystal at https://lab.engin.umich.edu/members/crystal-e-ashby/

Breakfast will be served!
Please, RSVP at the link below so we can provide enough food.
https://forms.gle/brHkoUmScrUt7H9h8

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Meeting Fri, 16 Aug 2019 13:04:40 -0400 2019-09-07T09:00:00-04:00 2019-09-07T11:00:00-04:00 Undergraduate Science Building MUSES Meeting
RNA innovation Seminar (September 9, 2019 4:00pm) https://events.umich.edu/event/65134 65134-16539445@events.umich.edu Event Begins: Monday, September 9, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Abstract: RNA regulation permeates neurobiology. Nociceptors are sensory neurons tasked with the detection of pain producing stimuli. Persistent changes in their activity, termed plasticity, benefit survival through injury avoidance. Nociceptors rely on cap-dependent translation to rapidly increase protein synthesis in response to pro-inflammatory signals. Comparatively little is known regarding the role of the regulatory factors bound to the 3' end of mRNA in nociceptor sensitization. Poly(A)-binding protein (PABP) stimulates translation initiation by bridging the Poly(A) tail to the eukaryotic initiation factor 4F complex associated with the mRNA cap. We have developed an RNA-based competitive inhibitor of PABP that attenuates behavioral responses to pain in mice. To identify the Poly(A) mRNAs subject to privileged translation in response to noxious cues, we have applied ribosome profiling to primary sensory neurons and tissues. A small number of transcripts are selectively translated in response to plasticity mediators. Among them is the capsid forming protein Arc. Arc has been implicated in synaptic plasticity and learning in the brain. We demonstrate that the ribosomal S6 kinase 1 is responsible for Arc production in nociceptors and describe a new role for local translation of Arc in afferent fibers. Collectively, our findings uncover mechanisms and targets of RNA control in sensory neurons that can be exploited to disrupt pain signaling.

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Lecture / Discussion Tue, 20 Aug 2019 15:48:42 -0400 2019-09-09T16:00:00-04:00 2019-09-09T17:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion flyer
From fluctuations to function: The role of dynamics in the mechanism and regulation of translation (September 10, 2019 4:00pm) https://events.umich.edu/event/63255 63255-15603733@events.umich.edu Event Begins: Tuesday, September 10, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Over the past two decades, stunning breakthroughs in the field of structural biology have continued to produce groundbreaking high-resolution structures of large, multi-component biomolecular machines. Comparative analyses of these static structures reveals the remarkable conformational flexibility of these machines and hints at the significant structural rearrangements that evidently accompany their functional cycles. Unfortunately, the experimental observation and characterization of these conformational dynamics is severely impeded by the size and complexity of biomolecular machines, severely limiting our understanding of the contributions that dynamics make to their functions. Using a combination of single-molecule biophysical-, structural-, and biochemical approaches, my research group aims to overcome these challenges and elucidate the precise roles that the conformational dynamics of biomolecular machines play in driving and controlling their functions. My seminar presentation will primarily focus on our studies of the mechanism and regulation of messenger RNA translation into protein by the ribosome, an essential step in gene expression. Specifically, I will discuss how thermally driven fluctuations of the ribosome and other essential translation components contribute to the mechanism and regulation of translation. Because the ribosome is the target of over half of all currently prescribed antibiotics and because of the growing list of human diseases to which deregulation of translation has been causally linked, our findings hold great promise for informing the development of next-generation antibiotics and small-molecule therapeutic agents that function by modulating the conformational dynamics of the translation machinery. Building on what we have learned from these studies, I will close my presentation by describing recent technological advances that are allowing us to investigate biomolecular dynamics which play important roles in biological mechanisms, but that have thus far remained difficult or impossible to investigate.




Ruben Gonzalez (Columbia University)

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Other Tue, 10 Sep 2019 18:15:37 -0400 2019-09-10T16:00:00-04:00 2019-09-10T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
DCMB Seminar - Neurons in pathology through the lens of multi-omics and data analytics (September 11, 2019 4:00pm) https://events.umich.edu/event/65485 65485-16605630@events.umich.edu Event Begins: Wednesday, September 11, 2019 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract:

Advances in stem cell engineering, omics technologies and data sciences offer a unique scope for deciphering the myriad ways molecular circuits dysfunction in pathologies of the brain. Recently, we have developed and explored iPSC-derived neurons from familial Alzheimer’s disease patients using a systems-level, multi-omics approach, identifying disease-related endotypes, which are commonly dysregulated in patient-derived neurons and patient brain tissue alike. By integrating RNA-Seq, ATAC-Seq, and ChIP-Seq approaches, we determined that the defining disease-causing mechanism of AD is de-differentiation of neurons, driven primarily through the REST-mediated repression of neuronal lineage specification gene programs and the activation of cell cycle reentry and non-specific germ layer precursor gene programs concomitant with modifications in chromatin accessibility. Strikingly, our reanalysis of previously-generated AD-patient brain tissue showed similar enrichment of neuronal repression and de-differentiation mechanisms. Surprisingly, our earlier work on glioblastoma also showed de-differentiation and initiation of some of the shared diseased endotypes as common features. We postulate that de-differentiation and reprogramming are hallmark mechanisms of numerous pathologies, arguably genetically evolved to serve as protection mechanisms.

Acknowledgements: This work was done in collaboration with the Laboratory of Dr. Wagner and his colleagues.

References:
Caldwell AB, Liu Q, Schroth GP, Tanzi RE, Galasko DR, Yuan SH, Wagner SL, Subramaniam S. Dedifferentiation orchestrated through remodeling of the chromatin landscape defines PSEN1 mutation-induced Alzheimer's Disease. 2019 (under revision in Nature) Available from: https://www.biorxiv.org/content/10.1101/531202v1.
Friedmann-Morvinski D, Bhargava V, Gupta S, Verma IM, Subramaniam S. Identification of therapeutic targets for glioblastoma by network analysis. Oncogene. 2016;35(5):608-20. PMCID: 4641815.
Bhargava V, Ko P, Willems E, Mercola M, Subramaniam S. Quantitative transcriptomics using designed primer-based amplification. Sci Rep. 2013;3:1740. PMCID: 3638165.

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Lecture / Discussion Tue, 20 Aug 2019 13:49:51 -0400 2019-09-11T16:00:00-04:00 2019-09-11T17:00:00-04:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
Growth and Grit: Developing a Mindset for Success (September 11, 2019 5:30pm) https://events.umich.edu/event/65979 65979-16678382@events.umich.edu Event Begins: Wednesday, September 11, 2019 5:30pm
Location: Angell Hall
Organized By: Science Learning Center

What if your ability to succeed in your classes was determined in part before you even stepped into the classroom? What is the one quality you need to overcome adversity academically and in life? This workshop will detail the research of Dr. Carol Dweck and her groundbreaking work on the concept of mindset. Students will learn how to abandon a debilitating fixed mindset in favor of a growth mindset, leading to success in areas they once considered too difficult. The workshop will also introduce students to the research of Dr. Angela Duckworth, and how a growth mindset can lead to the development of grit, an essential characteristic to overcoming our fear of failure.

Registration Link: http://ttc.iss.lsa.umich.edu/undergrad/sessions/growth-and-grit-developing-a-mindset-for-success-science-success-series/

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Workshop / Seminar Thu, 09 Jan 2020 13:40:53 -0500 2019-09-11T17:30:00-04:00 2019-09-11T19:00:00-04:00 Angell Hall Science Learning Center Workshop / Seminar
Pushing the Limits: Mass Spectrometry of Arctic Atmospheric Chemistry (September 12, 2019 4:00pm) https://events.umich.edu/event/64128 64128-16165588@events.umich.edu Event Begins: Thursday, September 12, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry




Kerri Pratt (University of Michigan)

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Other Thu, 12 Sep 2019 18:15:35 -0400 2019-09-12T16:00:00-04:00 2019-09-12T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Biophysics Krimm Lecture - Talk Title: Shining light onto the dark matter of biology: Ion flux modulation and the perplexing resilience of bacteria (September 13, 2019 12:00pm) https://events.umich.edu/event/64266 64266-16274470@events.umich.edu Event Begins: Friday, September 13, 2019 12:00pm
Location: Rackham Graduate School (Horace H.)
Organized By: LSA Biophysics

Abstract: TBD

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Workshop / Seminar Wed, 04 Sep 2019 14:42:01 -0400 2019-09-13T12:00:00-04:00 2019-09-13T13:30:00-04:00 Rackham Graduate School (Horace H.) LSA Biophysics Workshop / Seminar Rackham Graduate School (Horace H.)
Boron Cluster Building Blocks and Synthetic Reagents (September 17, 2019 4:00pm) https://events.umich.edu/event/65046 65046-16509306@events.umich.edu Event Begins: Tuesday, September 17, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry



TBD




Alexander Spokoyny (UCLA)

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Other Tue, 17 Sep 2019 18:15:51 -0400 2019-09-17T16:00:00-04:00 2019-09-17T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Make It Stick: Research-Based Learning Strategies You Need to Know (September 18, 2019 5:30pm) https://events.umich.edu/event/65980 65980-16678383@events.umich.edu Event Begins: Wednesday, September 18, 2019 5:30pm
Location: Angell Hall
Organized By: Science Learning Center

The study and learning strategies students often bring to college are often insufficient to help them succeed at the university level. Particularly in challenging STEM courses, students can't simply memorize or cram their way to a good grade. This workshop will focus on the popular learning strategies to avoid, as well as the top three strategies you don't know but are shown by research to be the most effective for long-term learning.

Registration Link: http://ttc.iss.lsa.umich.edu/undergrad/sessions/make-it-stick-research-based-learning-strategies-you-need-to-know-science-success-series/

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Workshop / Seminar Wed, 04 Sep 2019 15:39:54 -0400 2019-09-18T17:30:00-04:00 2019-09-18T19:00:00-04:00 Angell Hall Science Learning Center Workshop / Seminar
Unconventional techniques of imaging and microscopy for bio-medical applications. (September 19, 2019 4:00pm) https://events.umich.edu/event/62913 62913-15494564@events.umich.edu Event Begins: Thursday, September 19, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


Over the last few years a significant effort has been directed towards unconventional imaging techniques, such as microscopy without lenses as it can overcome some of the drawbacks associated with tradition optical microscopy, that rely on objective lenses, which results in a trade-off between the field of view and the resolution. Thus lens-less microscopy allows imaging and analysis over a wide area, enabling high throughput measurements, in addition to being cost-effective and portable. In this type of microscopy, the images are computationally reconstructed from in-line holograms, which result from the interference between the scattered optical wave from the sample and the directly transmitted wave. Here, I will present about lens-free on-chip microscopy designs, image reconstruction and its utility towards a wide range of applications related to sizing of nanoparticles, nanoparticle-aggregation, bio-sensing of pathogens and rare cancer cells, characterization of polymer degradation, material properties and rheology.











Aniruddha Ray

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Other Thu, 19 Sep 2019 18:15:48 -0400 2019-09-19T16:00:00-04:00 2019-09-19T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Biophysics Talk Title: "Emerging methods in solution NMR and applications to illuminate blind spots in human biology” (September 20, 2019 12:00pm) https://events.umich.edu/event/64267 64267-16274479@events.umich.edu Event Begins: Friday, September 20, 2019 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Abstract: TBD

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Workshop / Seminar Wed, 04 Sep 2019 14:42:29 -0400 2019-09-20T12:00:00-04:00 2019-09-20T13:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
CSIEUM - Seminar TBD (September 20, 2019 4:00pm) https://events.umich.edu/event/64957 64957-16495250@events.umich.edu Event Begins: Friday, September 20, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

ChemEd
Darryl Boyd

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Other Fri, 20 Sep 2019 18:15:47 -0400 2019-09-20T16:00:00-04:00 2019-09-20T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Gateway NMR Meeting (September 21, 2019 8:00am) https://events.umich.edu/event/64651 64651-16404987@events.umich.edu Event Begins: Saturday, September 21, 2019 8:00am
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Registration: https://sites.google.com/umich.edu/gatewaynmr2019/home

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Meeting Fri, 26 Jul 2019 15:01:32 -0400 2019-09-21T08:00:00-04:00 2019-09-21T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Meeting Chemistry Dow Lab
Gateway NMR Meeting (September 22, 2019 8:00am) https://events.umich.edu/event/64651 64651-16404988@events.umich.edu Event Begins: Sunday, September 22, 2019 8:00am
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Registration: https://sites.google.com/umich.edu/gatewaynmr2019/home

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Meeting Fri, 26 Jul 2019 15:01:32 -0400 2019-09-22T08:00:00-04:00 2019-09-22T17:00:00-04:00 Chemistry Dow Lab LSA Biophysics Meeting Chemistry Dow Lab
MedChem Seminar (September 23, 2019 10:00am) https://events.umich.edu/event/67530 67530-16890100@events.umich.edu Event Begins: Monday, September 23, 2019 10:00am
Location:
Organized By: Department of Medicinal Chemistry

"Chemistry & Biology of Human DNA Ligases"

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Lecture / Discussion Mon, 23 Sep 2019 10:18:45 -0400 2019-09-23T10:00:00-04:00 2019-09-23T11:00:00-04:00 Department of Medicinal Chemistry Lecture / Discussion
MedChem Seminar (September 23, 2019 10:00am) https://events.umich.edu/event/67530 67530-16890101@events.umich.edu Event Begins: Monday, September 23, 2019 10:00am
Location:
Organized By: Department of Medicinal Chemistry

"Chemistry & Biology of Human DNA Ligases"

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Lecture / Discussion Mon, 23 Sep 2019 10:18:45 -0400 2019-09-23T10:00:00-04:00 2019-09-23T11:00:00-04:00 Department of Medicinal Chemistry Lecture / Discussion
Rowena Matthews Lectureship in Biological Chemistry (September 24, 2019 12:00pm) https://events.umich.edu/event/65273 65273-16563500@events.umich.edu Event Begins: Tuesday, September 24, 2019 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Wilfred van der Donk will present the 2nd annual Rowena Matthews Lectureship in Biological Chemistry on Tuesday September 24th, 2019. The title of this talk is "Natural Product Biosynthesis by Post Translational Modification." The lecture will be held in Medical Science Unit II from 12:00pm to 1:00pm.

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Lecture / Discussion Wed, 18 Sep 2019 06:17:48 -0400 2019-09-24T12:00:00-04:00 2019-09-24T13:00:00-04:00 Medical Science Unit II Biological Chemistry Lecture / Discussion Wilfred van der Donk, Ph.D.
Advancing The Original Cope Rearrangement: Fundamental studies and applications in complex molecule synthesis (September 24, 2019 4:00pm) https://events.umich.edu/event/63771 63771-15873581@events.umich.edu Event Begins: Tuesday, September 24, 2019 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The original Cope rearrangement is an underutilized transformation in modern organic synthesis. Recognizing its potential, the Grenning lab seeks to transform this age old reaction into a versatile platform for complex molecule synthesis. Presented will be synthetic strategy, methodology, and applications in synthesis whereby this reaction plays a central role.








Alex Grenning (University of Florida)

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Other Tue, 24 Sep 2019 18:15:45 -0400 2019-09-24T16:00:00-04:00 2019-09-24T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Saltiel Life Sciences Symposium (September 25, 2019 8:45am) https://events.umich.edu/event/64209 64209-16212197@events.umich.edu Event Begins: Wednesday, September 25, 2019 8:45am
Location: Palmer Commons
Organized By: Life Sciences Institute (LSI)

The 2019 Saltiel Life Sciences Symposium will bring pioneers in the field of protein engineering to the University of Michigan to discuss the scientific advances driving the field forward.

Schedule:

8:45 a.m. | Welcome
Roger D. Cone, Ph.D.
Vice Provost and Director, U-M Biosciences Initiative; Mary Sue Coleman Director, Life Sciences Institute; Professor of Molecular and Integrative Physiology, Medical School; Professor of Molecular, Cellular, and Developmental Biology, College of Literature, Science, and the Arts

Mark S. Schlissel, M.D., Ph.D.
President of the University of Michigan

8:55 a.m. | Introduction of the Mary Sue and Kenneth Coleman Life Sciences Lecturer
Alan R. Saltiel, Ph.D.
Director, Institute for Diabetes and Metabolic Health, and Professor, University of California, San Diego School of Medicine; Director, Life Sciences Institute 2002-2015

9:00 a.m. | Mary Sue and Kenneth Coleman Life Sciences Lecture — Attacking the cell surface proteome in cancer
James A. Wells, Ph.D.
Harry W. and Diana V. Hind Distinguished Professor of Pharmaceutical Sciences, Professor of Pharmaceutical Chemistry, University of California, San Francisco

9:50 a.m. | Morning break

10:10 a.m. | Optogenetic and chemogenetic technologies for mapping molecular and cellular interactions
Alice Y. Ting, Ph.D.
Professor of Genetics, Biology, and Chemistry, Stanford University

11:00 a.m. | How do proteins evolve
Dan Tawfik, Ph.D.
Professor, Department of Biomolecular Sciences, Weizmann Institute of Science

11:50 a.m. | Poster session and lunch

1:20 p.m. | Biosystems design via directed evolution
Huimin Zhao, Ph.D.
Steven L. Miller Chair, Department of Chemical and Biomolecular Engineering; Professor of Chemistry, Biochemistry, Biophysics, an Bioengineering, University of Illinois at Urbana-Champaign

2:10 p.m. | Navigating the landscapes of protein interaction specificity
Amy E. Keating, Ph.D.Professor of Biology and Biological Engineering, Massachusetts Institute of Technology

3:00 p.m. | Afternoon break

3:20 p.m. |Design, evolution and applications of protein cages
Donald Hilvert, Ph.D.
Professor, Department of Chemistry and Applied Biosciences, ETH Zürich

4:10 p.m. | Closing remarks

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Conference / Symposium Thu, 29 Aug 2019 10:13:02 -0400 2019-09-25T08:45:00-04:00 2019-09-25T16:15:00-04:00 Palmer Commons Life Sciences Institute (LSI) Conference / Symposium 2019 Saltiel Life Sciences Symposium
DCMB Seminar, "Bioinformatics in Drug Discovery" (September 25, 2019 2:30pm) https://events.umich.edu/event/66407 66407-16734206@events.umich.edu Event Begins: Wednesday, September 25, 2019 2:30pm
Location: Taubman Biomedical Science Research Building
Organized By: DCMB Seminar Series

Abstract:
She’ll be describing the technologies and datasets her team uses to study human disease and develop new and improved treatments for their clients. She’ll cover the applications of traditional transcriptional profiling and sequence analysis as well as datasets and tools developed specifically for therapeutics development including CMap, Project Achilles, PRISM, functional CRISPR screening and others. She’ll also touch on topics like biomarker development, patient selection/stratification and gene therapy development. Along the way, she’ll describe what it’s like to work as a consultant, and how it differs from academic work or direct employment in the pharmaceutical industry.

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Lecture / Discussion Thu, 05 Sep 2019 11:01:32 -0400 2019-09-25T14:30:00-04:00 2019-09-25T15:30:00-04:00 Taubman Biomedical Science Research Building DCMB Seminar Series Lecture / Discussion