Happening @ Michigan https://events.umich.edu/list/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. Understanding and Controlling Electrochemistry for Electrolyzers and Batteries (October 21, 2021 4:00pm) https://events.umich.edu/event/84375 84375-21623627@events.umich.edu Event Begins: Thursday, October 21, 2021 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Analytical
Andrew Gewirth (University of Illinois at Urbana/Champaign)

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Other Thu, 21 Oct 2021 18:15:26 -0400 2021-10-21T16:00:00-04:00 2021-10-21T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
The Trichloroethylene Metabolite S-(1,2-dichlorovinyl)-L-cysteine Suppresses Inflammatory Pathways in a Macrophage Cell Model: Implications for Immunosuppression During Pregnancy (October 26, 2021 12:00pm) https://events.umich.edu/event/88558 88558-21655081@events.umich.edu Event Begins: Tuesday, October 26, 2021 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

https://umich.zoom.us/s/95313929320

The goal of the environmental research seminar/webinar is to provide an interdisciplinary forum for sharing and critiquing research proposals and preliminary study results.

Dr. Harris is a Research Assistant Professor of Environmental Health Sciences in the School of Public Health at the University of Michigan. Dr. Harris earned his PhD in environmental toxicology from the University of Washington, where he conducted his dissertation research in male reproductive toxicology. As part of his research he helped to develop an in vitro testis cell culture model for studying male reproductive toxicants. He now studies female reproductive toxicology, using a combination of approaches including primary tissue culture models, transcriptomics and metabolomics to investigate molecular mechanisms of toxicant effects on the placenta and fetal membranes. His research aims to advance our understanding of how environmental toxicants contribute to adverse pregnancy outcomes.

https://umich.zoom.us/s/95313929320

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Lecture / Discussion Mon, 25 Oct 2021 11:02:57 -0400 2021-10-26T12:00:00-04:00 2021-10-26T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Sean Harris Oct 26 Environmental Research Webinar
TBA (October 26, 2021 3:00pm) https://events.umich.edu/event/86895 86895-21637179@events.umich.edu Event Begins: Tuesday, October 26, 2021 3:00pm
Location: Off Campus Location
Organized By: Department of Chemistry


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Other Tue, 26 Oct 2021 06:15:22 -0400 2021-10-26T15:00:00-04:00 2021-10-26T16:00:00-04:00 Off Campus Location Department of Chemistry Other
Department of Computational Medicine & Bioinformatics Weekly Seminar (October 27, 2021 4:00pm) https://events.umich.edu/event/88276 88276-21652019@events.umich.edu Event Begins: Wednesday, October 27, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:
Molecular classification has transformed the diagnosis and treatment of diffuse gliomas, creating targets for precision therapies. However, timely and efficient access to molecular diagnostic methods remains difficult, causing a significant barrier to deliver molecularly-targeted therapies. We aim to develop an innovative point-of-care diagnostic screening method that provides rapid and accurate molecular classification of diffuse gliomas through artificial intelligence and optical imaging in order to improve the comprehensive care of brain tumor patients.

Bio:
Dr. Todd Hollon is a neurosurgeon and research scientist who specializes in brain tumors. He is an Assistant Professor of Neurosurgery. He completed his postdoctoral training in the UM Translational Molecular Imaging Laboratory under the supervision of Drs. Daniel Orringer and Honglak Lee. His postdoctoral work focused on the application of deep neural networks to advanced imaging methods to improve the speed and accuracy of intraoperative brain tumor diagnosis. He hopes to be part of the next generation of young scientists that uses computation and machine learning to make scientific breakthroughs.

Host: Josh Welch, PhD

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

In-Person: Forum Hall, Palmer Commons

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Livestream / Virtual Thu, 14 Oct 2021 14:26:31 -0400 2021-10-27T16:00:00-04:00 2021-10-27T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual
STEM Research Career Award (October 27, 2021 4:00pm) https://events.umich.edu/event/87133 87133-21639078@events.umich.edu Event Begins: Wednesday, October 27, 2021 4:00pm
Location: Off Campus Location
Organized By: Office of National Scholarships & Fellowships (ONSF)

Register here: https://myumi.ch/O4eKQ

The U-M STEM Research Career Award supports highly qualified students who plan to pursue a PhD and research career in a STEM field.

The scholarship provides $5000 for summer research or other academic expenses. The scholarship does not require US citizenship; it is open to students from all nationalities and backgrounds. The U-M STEM Research Career Award application and letters of recommendation will also be used to select U-M’s nominees for the Goldwater and Astronaut Scholarships from among eligible applicants.

Learn more: https://lsa.umich.edu/onsf/scholarships/stem-biomedical/u-m-stem-research-career-award.html

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Livestream / Virtual Tue, 19 Oct 2021 13:30:18 -0400 2021-10-27T16:00:00-04:00 2021-10-27T17:00:00-04:00 Off Campus Location Office of National Scholarships & Fellowships (ONSF) Livestream / Virtual Chemical engineers develop clean energy storage solutions
Writing Graduate School Application Statements (October 29, 2021 3:00pm) https://events.umich.edu/event/88774 88774-21657750@events.umich.edu Event Begins: Friday, October 29, 2021 3:00pm
Location: Off Campus Location
Organized By: Futures in Research, Science, Teaching - FIRST

What to include/avoid and how to frame your story while writing academic and personal statements for research-based grad programs.

Seminar/Discussion

Zoom Link: https://umich.zoom.us/j/95163992475

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Workshop / Seminar Fri, 29 Oct 2021 12:12:00 -0400 2021-10-29T15:00:00-04:00 2021-10-29T16:00:00-04:00 Off Campus Location Futures in Research, Science, Teaching - FIRST Workshop / Seminar FIRST Logo
Bayesian models for mercury effects on multiple outcomes in the Seychelles Child Development Study (November 2, 2021 12:00pm) https://events.umich.edu/event/88561 88561-21655084@events.umich.edu Event Begins: Tuesday, November 2, 2021 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Sally W. Thurston, PhD is an Associate Professor of Biostatistics and Environmental Medicine, University of Rochester, Dept of Biostatistics and Computational Biology.

ABSTRACT: The Seychelles Child Development Study (SCDS) Main Cohort was recruited to investigate the association between prenatal mercury (Hg) exposure from maternal fish consumption and the children’s subsequent development. Multiple neurodevelopmental outcomes were measured at several discrete ages. These outcomes can be grouped into different classes or "domains", such as cognition, motor, or memory. Associations of Hg and covariates may differ across outcomes and domains. Motivated by the SCDS, I will first discuss a model for multiple outcomes at a single age under the assumption that each outcome belongs to one domain and domain memberships are known. I will then briefly describe two extensions: a model in which outcomes may have partial domain membership in more than one domain, and a longitudinal multiple outcomes model for cognition when the tests of cognition change with the age of the child.

The goal of Environmental Statistics Week is to disseminate knowledge of advanced statistical methods most relevant to environmental health research with expert-led discussions on statistical concepts.

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Lecture / Discussion Fri, 22 Oct 2021 16:34:57 -0400 2021-11-02T12:00:00-04:00 2021-11-02T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion 2021 Environmental Statistics Week
Traversing charge dynamics landscapes: Reduced dimensionality-inspired design of organic-metal halide semiconductors for energy applications (November 2, 2021 4:00pm) https://events.umich.edu/event/84363 84363-21623582@events.umich.edu Event Begins: Tuesday, November 2, 2021 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Organic-inorganic interfaces while highly desirable for a host of applications, present several challenges that remain unresolved, including the ability to control the assembly of the organic and inorganic components and interfaces at the molecular level (orientation and mode of attachment), matching of phonon band structure in inorganics with discrete vibrations within the molecule, and tuning energetic offsets for effective charge and spin transfer. Each of these parameters ultimately govern charge transport, the preservation of coherence, and energy transfer.
In this talk, I will discuss fundamental guidelines for the design of well-defined organic-inorganic heterostructured materials with controlled morphology and interfaces that serve as conduits for deterministic and coherent spin and charge transfer. I will divide my talk into two different sub-topics, i.e., (1) how matching phonon structure across interfaces through control of mode and site of attachment of molecules to surfaces allow for efficient coherent charge transfer and (2) how topologically protected electronic states can be defined by 2D assembly of pi-conjugated molecules and layered organic-inorganic hybrid materials on surfaces for spin-coherent electronic transport. Here, I will emphasize the role that dimensionality plays in modulating the spin and charge properties of organic-inorganic hybrid structures. The common thread between these two sub-topics is the fundamental understanding of energy and charge transfer at the interfaces of organic-inorganic hybrid materials to control charge (spin) injection, transport, manipulation, and detection with implications for photovoltaics, energy storage, quantum electronics, and spintronics.
Luisa Whittaker-Brooks (University of Utah)

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Other Tue, 02 Nov 2021 18:15:31 -0400 2021-11-02T16:00:00-04:00 2021-11-02T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Department of Computational Medicine & Bioinformatics Weekly Seminar (November 3, 2021 4:00pm) https://events.umich.edu/event/88449 88449-21654119@events.umich.edu Event Begins: Wednesday, November 3, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract
My research group works in the area of mathematical oncology, where we use mathematical models to decipher the complex networks of reactions inside of cancer cells and interactions between cells. Immune cells use hundreds of biochemical reactions to respond to their environment, become activated, and kill cancer cells. Understanding the complexity of these reaction networks requires computational tools and mathematical models. We combine detailed, mechanistic modeling with machine learning to study these networks, better understand cancer and immune cells, and predict ways to control tumor growth. In this talk, I will present our recent work aimed at predicting the dynamics of immune cell behaviors across three scales: intracellular signaling pathways in CAR T cells, the collective behavior of a heterogeneous population of immune cells, and tumor-immune interactions at the tissue scale. Our models generate novel mechanistic insight into immune cell activation and predict the effects of immunotherapeutic strategies.


Biography
Stacey D. Finley is the Gordon S. Marshall Early Career Chair and Associate Professor of Biomedical Engineering at the University of Southern California. Dr. Finley received her B.S. in Chemical Engineering from Florida A & M University and obtained her Ph.D. in Chemical Engineering from Northwestern University. She completed postdoctoral training at Johns Hopkins University in the Department of Biomedical Engineering. Dr. Finley joined the faculty at USC in 2013, and she leads the Computational Systems Biology Laboratory. Dr. Finley has joint appointments in the Departments of Chemical Engineering and Materials Science and Quantitative and Computational Biology, and she is a member of the USC Norris Comprehensive Cancer Center. Dr. Finley is also the Founding Director of the Center for Computational Modeling of Cancer at USC. Her research is supported by grants from NSF, NIH, and the American Cancer Society.

Selected honors. 2016 NSF Faculty Early CAREER Award; 2016 Young Innovator by the Cellular and Molecular Bioengineering journal; Leah Edelstein-Keshet Prize from the Society of Mathematical Biology; Junior Research Award from the USC Viterbi School of Engineering; the Hanna Reisler Mentorship Award; 2018 AACR NextGen Star; 2018 Orange County Engineering Council Outstanding Young Engineer; Elected Fellow of the American Institute for Medical and Biological Engineering (2021)

Hosted by: Alan Boyle, PhD

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Wed, 20 Oct 2021 09:54:50 -0400 2021-11-03T16:00:00-04:00 2021-11-03T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual Stacey D. Finley, Ph.D. (USC)
What do we learn from the environmental surveillance of SARS-CoV-2 on and off campus? (November 4, 2021 12:00pm) https://events.umich.edu/event/88563 88563-21655086@events.umich.edu Event Begins: Thursday, November 4, 2021 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Chuanwu Xi, PhD, is a Professor of Environmental Health Sciences and Global Public Health in the School of Public Health, University of Michigan.

The goal of Environmental Statistics Week is to disseminate knowledge of advanced statistical methods most relevant to environmental health research with expert-led discussions on statistical concepts.

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Lecture / Discussion Fri, 22 Oct 2021 16:48:21 -0400 2021-11-04T12:00:00-04:00 2021-11-04T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion 2021 Environmental Statistics Week
RNA Innovation Seminar (November 8, 2021 4:00pm) https://events.umich.edu/event/86167 86167-21631759@events.umich.edu Event Begins: Monday, November 8, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

"Harnessing diverse compact CRISPR-Cas3 for long-range genome engineering"
Zhonggang Hou, Ph.D.
Research Investigator
Biological Chemistry

and

"Microscopic Examination of Spatial Transcriptome through Seq-Scope"
Jun Hee Lee, PhD
Associate Professor
Molecular & Integrative Physiology

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Lecture / Discussion Mon, 25 Oct 2021 13:33:17 -0400 2021-11-08T16:00:00-05:00 2021-11-08T20:00:00-05:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Zhonggang Hou, Biological Chemistry & Jun Hee Lee, Molecular & Integrative Physiology
Per- and Polyfluoroalkyl Substances (PFAS) and Women’s Reproductive Health: Findings from the Study of Women’s Health Across the Nation (SWAN) (November 9, 2021 12:00pm) https://events.umich.edu/event/88884 88884-21658815@events.umich.edu Event Begins: Tuesday, November 9, 2021 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

https://umich.zoom.us/s/97831201308

Dr. Ding is a postdoctoral research fellow focusing on environmental epidemiology in the Department of Epidemiology, School of Public Health, University of Michigan.

The goal of the environmental research seminar/webinar is to provide an interdisciplinary forum for sharing and critiquing research proposals and preliminary study results.

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Lecture / Discussion Tue, 02 Nov 2021 10:04:20 -0400 2021-11-09T12:00:00-05:00 2021-11-09T12:50:00-05:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Ning Ding ER Seminar (11-09-2021)
Department of Computational Medicine & Bioinformatics Weekly Seminar (November 10, 2021 4:00pm) https://events.umich.edu/event/88540 88540-21654960@events.umich.edu Event Begins: Wednesday, November 10, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

Subspace classifiers have been around for a long time, beginning with feature selection, which in essence was a subspace selection technique. This talk will discuss the kind of subspace classifiers that Bledsoe and Browning presented in their 1959 paper and from which there have been a variety of extensions which we will discuss.

The Bledsoe and Browning subspace classifier quantizes measurement space. Each quantized observation tuple corresponds to a cell in measurement space. A collection of subspaces are selected at random. In the original form the subspaces were mutually exclusive. For each class, each cell of a subspace contained a number dependent on the number of observations of the training data that fell into that cell. For each class those numbers were combined in ways not dissimilar to random forests. For a given observation tuple, the class with the highest vote count was selected as the assigned class.

We will discuss a variety of principled extensions of the technique and make some comparisons with Neural Networks.

Research Interests:

High-dimensional space clustering, pattern recognition, knowledge discovery and artificial intelligence

Professor Haralick began his work as one of the principal investigators of the NASA ERTS satellite data doing remote sensing image analysis.

He has made a series of contributions in the field of computer vision. In the high-level vision area, he has worked on inferring 3D geometry from one or more perspective projection views.] He has also identified a variety of vision problems which are special cases of the consistent labeling problem. His papers on consistent labeling, arrangements, relation homomorphism, matching, and tree search translate some specific computer vision problems to the more general combinatorial consistent labeling problem and then discuss the theory of the look-ahead operators that speed up the tree search. The most basic of these is called Forward Checking. This gives a framework for the control structure required in high-level vision problems. He has also extended the forward-checking tree search technique to propositional logic.

Zoom: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Fri, 22 Oct 2021 09:28:27 -0400 2021-11-10T16:00:00-05:00 2021-11-10T17:00:00-05:00 Off Campus Location DCMB Seminar Series Livestream / Virtual Robert M. Haralick, PhD (City University of New York)
LSI Seminar Series: Björn Hamberger, Ph.D., Michigan State University (November 11, 2021 12:00pm) https://events.umich.edu/event/88795 88795-21657769@events.umich.edu Event Begins: Thursday, November 11, 2021 12:00pm
Location: Off Campus Location
Organized By: Life Sciences Institute (LSI)

*Abstract:*
Plant specialized products have co-evolved over 450 million years with their enemies: pests, pathogens and feeding animals. Terpenes specifically are a hallmark of effective plant defense, yet humans have also discovered their value as flavors, fragrances, cosmetics and therapeutics since the dawn of civilization. In modern times, natural products represent for the industry the entire spectrum of compounds from green solvents to agrichemicals and high-value antibiotics and pharmaceuticals. Instead of using inherently petrol-based, formal chemical synthesis for their access, our team is interested in learning from plants how these compounds are made and in exploring the plant routes for biotechnological applications. The knowledge is already empowering new approaches to explore the uncharted territory of their chemistries for biosustainable production.

This talk will highlight highly diverse endeavors and the challenges tackled by the students on our team. Specifically, we were hunting pathways to the plant-based drugs ingenol (anti-cancer), triptolide (immunomodulatory, anti-viral) and forskolin (silver-bullet drug). This research has revealed non-canonical enzymatic steps, unusual substrates and unexpected promiscuity. Plant species we are excited about are increasing on a nearly weekly basis, but we are currently focusing on members of the coffee (Rubiaceae) and mint (Lamiaceae) families. New technical advances (sequencing, analytics) have already changed the traditional ways we approach these plants. A few key features make the work particularly exciting for of our team: diverse collaborations bridging phytochemistry, biochemistry, molecular biology, bioinformatics and engineering of biotech host species. Collectively, this represents one of the many facets of synthetic biology.

*About the Speaker*
With a background in chemistry, the training of Björn Hamberger expands from biochemistry and molecular biology to plant synthetic biology. The research of his team, established in 2016 at Michigan State University, approaches the discovery of plant pathways in non-model medicinal plants accumulating bioactive specialized metabolites with pharmacological activities and their biotechnological production. The publication record of Hamberger’s team highlights an interdisciplinary and highly cooperative research, with top-tier international journals, including contributions since 2016 to Science, PNAS, Angewandte Chemie, International Edition, eLife, Nature Communications, New Phytologist, the Journal of Biochemistry and the Plant Journal. His work, supported by two distinct MSU Strategic Partnership Programs has also yielded three Patent Applications. Hamberger's applied and technologically broad research approach also has been integrated in his teaching and mentoring efforts for undergraduate students, graduates and postdoctoral members of the team.

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Lecture / Discussion Fri, 29 Oct 2021 14:51:51 -0400 2021-11-11T12:00:00-05:00 2021-11-11T13:00:00-05:00 Off Campus Location Life Sciences Institute (LSI) Lecture / Discussion LSI Seminar Series
Building C-N Bonds in Electrocatalytic CO2 Reduction Reactions (November 11, 2021 4:00pm) https://events.umich.edu/event/84368 84368-21623614@events.umich.edu Event Begins: Thursday, November 11, 2021 4:00pm
Location: Off Campus Location
Organized By: Department of Chemistry

Electrochemical reactions, augmented by catalysis, are promising a new paradigm for treating air and water pollutions and turning pollutants such as CO2 and nitrate into useful chemicals. Albeit widely studied, electroreduction solely from CO2 and H2O has a limited product scope lacking elemental diversity. Integrating heteroatom-containing reactants into electrocatalytic CO2 reduction could expand the chemistry and enable the sustainable synthesis of valuable products, such as organonitrogen compounds, which have widespread applications but typically rely on energy-intensive and fossil-fuel-dependent processes for production. This talk will present our research progress towards building C-N bonds in N-integrated CO2 electroreduction. Combining molecule-nanocarbon hybridization and second-coordination-sphere tailoring, we discovered the first molecular electrocatalyst for CO2-to-methanol conversion in significant yield and stability. The reduction proceeds via formaldehyde, an intermediate potentially reactive to N nucleophiles. Following this path, we developed the first electrosynthesis of methylamine from CO2 and nitrate. This 15-proton 14-electron reduction reaction proceeds via an 8-step catalytic cascade with the spontaneous condensation reaction between the formaldehyde and hydroxylamine intermediates to form the C-N bond. Further, we advanced the chemistry to ethylamine formation and N-methylation reactions, opening the door for our electrocatalytic reactions to be used for organic synthesis using CO2/nitrate as a C1/N1 building block.




Hailiang Wang (Yale University)

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Other Thu, 11 Nov 2021 18:15:21 -0500 2021-11-11T16:00:00-05:00 2021-11-11T17:30:00-05:00 Off Campus Location Department of Chemistry Other
Presenting Your Research & Project Design (November 12, 2021 3:00pm) https://events.umich.edu/event/89144 89144-21660677@events.umich.edu Event Begins: Friday, November 12, 2021 3:00pm
Location: Off Campus Location
Organized By: Futures in Research, Science, Teaching - FIRST

A Zoom seminar on presenting to academic audiences, including basics of project design. Useful for those considering careers in science and/or preparing for grad school interviews that require a presentation.

Zoom link: https://umich.zoom.us/j/95315038837

FIRST linktree: https://linktr.ee/FIRST_Org

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Workshop / Seminar Wed, 10 Nov 2021 13:18:06 -0500 2021-11-12T15:00:00-05:00 2021-11-12T16:00:00-05:00 Off Campus Location Futures in Research, Science, Teaching - FIRST Workshop / Seminar FIRST Logo. The letters of "FIRST" are made up of chromosomes tethered to spindles during mitosis.
Polymers and functional graphenic materials as stem cell instructive scaffolds for bone regeneration (November 16, 2021 11:30am) https://events.umich.edu/event/86366 86366-21633048@events.umich.edu Event Begins: Tuesday, November 16, 2021 11:30am
Location: Off Campus Location
Organized By: Department of Chemistry

The Sydlik group at Carnegie Mellon uses chemical signals and intelligently designed materials to instruct bone regeneration. To do this, we use polymers and functional graphenic materials (FGMs) to create new biomaterials that offer tunable mechanical properties, degradability, and surface chemistry, which together can be used to control bioactivity. FGMs, are degradable in in vivo, but the application of FGMs as biomaterials have been limited due to insufficient control of the chemical interface and limited processing methods. To address this, the Sydlik group has developed new methods to covalently bind polymers and other biomimetic moieties to the surface of FGMs using classic organic reactions. Using these novel organic transformations, we can impart surface functionalization. This produces FGMs with tunable surface chemistry, allowing installation of cell instructive moieties, and improved mechanical properties arising from graphene reduction. We have developed FGMs that inherently induce osteogenesis in vitro and in vivo. Specifically, our modified Arbuzov reaction couples polyphosphate on the GO backbone with control over a variety of bioinstructive counter ions (Ca2+, K+, Li+, Mg2+, or Na+). Ca2+, Li+, Mg2+, and PO4-. These ions are known to be inducerons, or small ions that encourage the osteogeneic differentiation of stem cells. Further, we have shown that calcium phosphate graphene (CaPG) induces osteogenesis in vivo in a mouse model. These materials are designed to degrade in water, and to release signals known to drive regenerative healing in their process of degradation. We have also developed a new class of peptide-graphene covalent conjugate and are working to show that FGMs can serve as intrinsically inductive, autodegradable scaffolds for bone regeneration in vivo.
Stefanie Sydlik (Carnegie Mellon University)

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Other Tue, 16 Nov 2021 18:15:33 -0500 2021-11-16T11:30:00-05:00 2021-11-16T13:30:00-05:00 Off Campus Location Department of Chemistry Other
Assessing Hybrid Molecular Platforms for Next Generation Quantum Technologies (November 16, 2021 4:00pm) https://events.umich.edu/event/88912 88912-21658956@events.umich.edu Event Begins: Tuesday, November 16, 2021 4:00pm
Location: Off Campus Location
Organized By: Department of Chemistry

Quantum control over light and matter is poised to enable future capabilities beyond the reach of current technologies in chemical synthesis, energy harvesting, and information processing and storage. Despite this promise, the fundamental physical drivers of quantum control in proposed platforms remain unclear. In this talk, I will present results from fundamental studies of structure-property relationships in two disparate hybrid molecular systems of emerging interest to the chemistry community. First, I will present results from our studies on the chemistry and properties of mid-gap states formed in self-assembled quantum nanostructures. These results indicate synthetic routes to the deterministic design of structural defects for the emission of narrowband light spectra central to solution-processed single photon sources and entangled photon generation in the established telecommunications band. Second, I will present results in the design, fabrication, and characterization of cavity polariton samples containing single and multiple chromophores. These results suggest the entanglement of light and matter states mediated by polariton formation opens new avenues to control ultrafast molecular photophysics and intermolecular interactions on truly quantum footing. These studies demonstrate the wealth of fundamental physical information central to the development of next generation molecular quantum technologies that can be attained from informed materials design and advanced spectroscopic characterization.
Aaron S. Rury (Wayne State University)

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Other Tue, 16 Nov 2021 18:15:33 -0500 2021-11-16T16:00:00-05:00 2021-11-16T17:30:00-05:00 Off Campus Location Department of Chemistry Other
DCMB / CCMB Weekly Seminar Series (November 17, 2021 4:00pm) https://events.umich.edu/event/89137 89137-21660643@events.umich.edu Event Begins: Wednesday, November 17, 2021 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Talk title: Clinical Trajectory analysis to determine risk-factors of Copd: A COPDGene Study

Abstract:

Background

Chronic obstructive pulmonary disease (COPD) presents significant clinical heterogeneity and a wide variety of progression trajectories [1]. Clinical trajectory analysis (ClinTrajAn) is a powerful tool based on elastic principal graphs for the calculation of trajectories from large cross-sectional clinical data sets [2].

Aims and objectives

Our objective was to determine potential risk-factors by evaluate progression trajectories in COPD using ClinTrajAn on the COPDGene Phase I (baseline visit) dataset.

Methods

7883 participants, current and former smokers with GOLD 0 thru 4 COPD, from Phase I of the COPDGene study, were utilized for this work. 55 features were obtained for each subject, including demographics, spirometry, smoking history and computed tomography (CT), which included Parametric Response Mapping (PRM). Developed by our group, PRM is capable of simultaneously measuring small airways disease and emphysema which are the main contributors of airflow limitations in COPD. The resulting data matrix was analyzed with ClinTrajAn.

Results

A principal tree, with 13 branch segments and 8 termini, was generated (Figure 1). There was a clearly recognized trajectory from healthier subjects through decreasing lung function and increasing age (Figure 1 A), increasing in GOLD (Figure 1 B), to an emphysema high terminus (Figure 1 C). Notably this method illustrated numerous branching points along this trajectory.

Conclusions

In this study we used ClinTrajAn to obtain a map of disease progression trajectories in COPD including clinically recognized pathogenesis. Our next steps will be to further validate this approach using longitudinal data from the COPDGene follow-up visits.

References

1. Han MK, Agusti A, Calverley PM, Celli BR, Criner G, Curtis JL, Fabbri LM, Goldin JG, Jones PW, MacNee W, Make BJ. Chronic obstructive pulmonary disease phenotypes: the future of COPD. American journal of respiratory and critical care medicine. 2010 Sep 1;182(5):598-604.

2. Golovenkin SE, Bac J, Chervov A, Mirkes EM, Orlova YV, Barillot E, Gorban AN, Zinovyev A. Trajectories, bifurcations, and pseudo-time in large clinical datasets: applications to myocardial infarction and diabetes data. GigaScience. 2020 Nov;9(11):giaa128.

Zoom link: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Lecture / Discussion Wed, 10 Nov 2021 09:47:40 -0500 2021-11-17T16:00:00-05:00 2021-11-17T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
Medical School Student Panel Discussion (November 18, 2021 3:30pm) https://events.umich.edu/event/85497 85497-21626705@events.umich.edu Event Begins: Thursday, November 18, 2021 3:30pm
Location: Off Campus Location
Organized By: Science Learning Center

Here is your chance to hear about what life is like for several medical school students and residents. Learn about each of their paths to medicine, experiences in medical school, and things they wished they had known in college. You can also submit your own questions ahead of time using the following link: https://myumi.ch/2D299

Register on Sessions: https://myumi.ch/pdYmj

Email ScienceSuccessSeries@umich.edu with any questions.

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Workshop / Seminar Fri, 20 Aug 2021 11:59:04 -0400 2021-11-18T15:30:00-05:00 2021-11-18T17:00:00-05:00 Off Campus Location Science Learning Center Workshop / Seminar
What 2DIR Can Tell Us About Complex and Heterogeneous Biophysical Systems (November 18, 2021 4:00pm) https://events.umich.edu/event/84163 84163-21620520@events.umich.edu Event Begins: Thursday, November 18, 2021 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

While two-dimensional infrared (2DIR) spectroscopy has been useful for studying properties of peptides and proteins, many of those results were made on “clean”, homogenous samples. My lab’s long-term goal is to turn the sensitive and ultrafast observables of 2DIR into useful image contrast agents for complex biophysical systems, where they can answer questions related to solvation dynamics and molecular structure that few other methods can address. To that end, I will present three projects from my lab that move us closer to this goal. 1: Proline-arginine (PR) dipeptide repeats are an example of a growing number of intrinsically disordered proteins (IDPs) that can assemble into membraneless organelles by Liquid-liquid phase separation (LLPS), and has also been implicated in the disease mechanism of Amyotrophic lateral sclerosis (ALS). We show that formation of droplets by PR20 accompanies changes in the Amide-I spectra consistent with folding into poly-proline helical structures, providing, to our knowledge, the first piece of evidence that LLPS can drive folding of IDPs. 2: For cross-α fibrils, recently discovered structures derived from the biofilms of virulent strains of Staphylococcus Aureus bacteria, the absorptive spectra are virtually indistinguishable from monomeric α-helices. As such, we performed a detailed study of the nonlinear infrared response of this system under a variety of experimental conditions and detail how polarization sensitive 2DIR, in combination with both broad-band time domain and narrow-band frequency domain spectroscopy, together revealed. a coherent nonlinear signature unique to α-fibrils. In addition, spatial scanning of the sample revealed underlying polymorphism in the fibrils, demonstrating that this peptide is capable of adopting both cross-α and cross-β fibril structure in the same environment. 3: Wide-field imaging through dielectric microspheres has emerged in recent years as a simple and effective approach for generating super-resolution images at visible wavelengths. We demonstrate that polystyrene dielectric microspheres can be used in a wide-field infrared (IR) microscope to enhance far field resolution as well. We observe a clear improvement in resolution and magnification when images are collected through polystyrene microspheres and anticipate that super-resolution could be achieved with the addition of high-quality IR objectives.



Arnaldo Serrano (University of Notre Dame)

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Other Thu, 18 Nov 2021 18:15:27 -0500 2021-11-18T16:00:00-05:00 2021-11-18T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Sustaining a Healthy Nail Salon Workforce in Michigan (November 23, 2021 12:00pm) https://events.umich.edu/event/89270 89270-21661657@events.umich.edu Event Begins: Tuesday, November 23, 2021 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Registration required
https://umich.zoom.us/s/98595068138

Aurora Le, PhD, MPH, CPH, CSP (John G. Searle Assistant Professor of Environmental Health Sciences, School of Public Health, University of Michigan) and Marie-Anne Rosemberg, PhD, MN, RN, FAAOHN (Assistant Professor, Dept. of Systems, Populations and Leadership, School of Nursing, University of Michigan), co-lead the Michigan Healthy Nail Salon Cooperative. The goal of the environmental research seminar/webinar is to provide an interdisciplinary forum for sharing and critiquing research proposals and preliminary study results.

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Lecture / Discussion Mon, 15 Nov 2021 13:38:28 -0500 2021-11-23T12:00:00-05:00 2021-11-23T12:50:00-05:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Nov 30 Environmental Research Webinar
Natural Products in the Atmosphere (November 30, 2021 11:30am) https://events.umich.edu/event/84397 84397-21623848@events.umich.edu Event Begins: Tuesday, November 30, 2021 11:30am
Location: Undergraduate Science Building
Organized By: Department of Chemistry

Volatile terpenes emitted from the world’s forests play a significant role in the formation of atmospheric aerosol particles, which in turn influence climate, air quality, and human health through a variety of direct and indirect mechanisms. Despite the importance of these aerosol particles, they remain poorly understood and continue to contribute the largest uncertainty to estimates of total radiative forcing. This lecture will describe efforts within my lab towards the synthesis of putative biogenic terpene-derived constituents of atmospheric aerosol particles in order to confirm their identities and explore their climate relevant physical properties. Recent advances in the synthesis of isotopically-labeled pinene derivatives that are driving collaborative investigations into the complex oxidation pathways of terpenes in the atmosphere will also be presented.


Regan Thomson (Northwestern)

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Other Tue, 30 Nov 2021 18:15:37 -0500 2021-11-30T11:30:00-05:00 2021-11-30T13:00:00-05:00 Undergraduate Science Building Department of Chemistry Other
Tuning Active Sites in Catalytic Nanomaterials through Colloidal Synthesis (November 30, 2021 4:00pm) https://events.umich.edu/event/84369 84369-21623615@events.umich.edu Event Begins: Tuesday, November 30, 2021 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Supported metal atoms and nanoparticles are found ubiquitously as heterogeneous catalysts for a wide variety of industrial, organic, and energy catalytic processes. The electronic and steric environment at the nanomaterial surface has a huge impact on the reactivity and selectivity of catalytic transformations occurring at surface active sites, but these properties are difficult to independently control through conventional materials synthetic methods. In this work, we develop molecularly-precise surface functionalization strategies in order to precisely tune both the ensemble geometry and redox properties of active site metal atoms. These strategies include 1) the adsorption of inorganic ligands on colloidal nanoparticle surfaces in order to synthesize monolayer and sub-monolayer core-shell catalysts, 2) control of bimetallic surface ensemble geometry to catalyze diastereoselective organic reactions, and 3) tuning the metal–sulfur coordination environment of single atoms supported on metal chalcogenide nanosheets for electrochemical catalysis. All of these strategies develop new structural frameworks for modulating the surface active site environment in order to access more reactive and selective nanomaterial catalysts.

Christina Li (Purdue University)

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Other Tue, 30 Nov 2021 18:15:37 -0500 2021-11-30T16:00:00-05:00 2021-11-30T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Precision Synthesis of Quantum Material Building Blocks (December 1, 2021 12:00pm) https://events.umich.edu/event/89132 89132-21660579@events.umich.edu Event Begins: Wednesday, December 1, 2021 12:00pm
Location: Off Campus Location
Organized By: Department of Chemistry

Quantum materials are poised to transform the development of next-generation sensors,
analytical instruments, information processing systems, and energy conversion platforms. Realizing these lofty goals will require low-dimensional crystals whose size, shape, structure, and composition can be tailored to atomic levels of precision. Chemistry will play a vital role in creating these crystalline building blocks of quantum matter. In this vein, the Kempa group has focused on the precision synthesis of 2-dimensional (2D) materials to harness quantum phenomena. Our work with 2D atomic lattices and 2D molecular frameworks has revealed that even subtle manipulations of the dimensionality and morphology of these materials yield substantial property changes. Notably, we can dramatically manipulate the structure of 2D transition-metal dichalcogenides by
growing them on chemically tailored surfaces. The resulting nanoribbons emit light whose energy and profile show an unusual progression with crystal size. Seeking to expand the 2D materials landscape, we have also prepared and examined new 2D molecular frameworks. Reversible phase switching can be induced in these frameworks with concomitant modulation of electronic transport. Our efforts underscore the importance of rational synthesis in building low-dimensional materials that enable new discoveries and advance the fields of optics, electronics, energy conversion, and quantum sensing.
Thomas Kempa (Johns Hopkins University)

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Other Wed, 01 Dec 2021 18:15:30 -0500 2021-12-01T12:00:00-05:00 2021-12-01T13:15:00-05:00 Off Campus Location Department of Chemistry Other
Department of Computational Medicine & Bioinformatics Weekly Seminar (December 1, 2021 4:00pm) https://events.umich.edu/event/88514 88514-21654664@events.umich.edu Event Begins: Wednesday, December 1, 2021 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract:

Epigenetic control of gene expression is highly cell-type- and context-specific. Yet, despite its complexity, gene regulatory logic can be broken down into modular components consisting of a transcription factor (TF) activating or repressing the expression of a target gene through its binding to a cis-regulatory region. Recent advances in joint profiling of transcription and chromatin accessibility with single-cell resolution offer unprecedented opportunities to interrogate such regulatory logic. Here, we propose a nonparametric approach, TRIPOD, to detect and characterize three-way relationships between a TF, its target gene, and the accessibility of the TF’s binding site, using single-cell RNA and ATAC multiomic data. We apply TRIPOD to interrogate cell-type-specific regulatory logic in peripheral blood mononuclear cells and contrast our results to detections from enhancer databases, cis-eQTL studies, ChIP-seq experiments, and TF knockdown/knockout studies. We then apply TRIPOD to mouse embryonic brain data during neurogenesis and gliogenesis and identified known and novel putative regulatory relationships, validated by ChIP-seq and PLAC-seq. Finally, we demonstrate TRIPOD on SHARE-seq data of differentiating mouse hair follicle cells and identify lineage-specific regulation supported by histone marks for gene activation and super-enhancer annotations.

Hosted by: Joshua Welch, PhD

Speaker will be in-person and the seminar will be live-streamed via Zoom.

Zoom: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Lecture / Discussion Thu, 21 Oct 2021 14:55:35 -0400 2021-12-01T16:00:00-05:00 2021-12-01T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion Yuchao Jiang (Assistant Professor in the Departments of Biostatistics and Genetics at UNC)
3rd Year Analytical Student Seminars (December 2, 2021 4:00pm) https://events.umich.edu/event/89241 89241-21661209@events.umich.edu Event Begins: Thursday, December 2, 2021 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Analytical
Analytical Seminar Speaker

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Other Thu, 02 Dec 2021 18:15:31 -0500 2021-12-02T16:00:00-05:00 2021-12-02T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
SCSAP Monthly Seminar Series (December 6, 2021 1:00pm) https://events.umich.edu/event/89632 89632-21664587@events.umich.edu Event Begins: Monday, December 6, 2021 1:00pm
Location: Off Campus Location
Organized By: Single Cell Spatial Analysis Program (SCSAP)

Title: The mutational landscape and clonal dynamics of Human Somatic and Germline cells

During the course of a lifetime normal human cells accumulate mutations. Studying these mutations provides important insight into the development, maintenance and structure of normal tissues, the mutational processes that have been operative, and the role of selection in shaping cell populations. It can elucidate how each of these are altered by, or contribute to, cancer, other diseases, and ageing. However, characterising such mutations has been technically challenging, as normal cell populations consist of myriad small clones, with the mutations differing between clones. We employed laser capture microscopy combined with low input-DNA whole genome sequencing, to study clonal units across multiple cell types from the same individuals. We compared the mutational landscape in 29 cell types from the soma and germline. Our results revealed the extent of variation in clonal dynamics across tissues. Mutation rates vary between different cell types, with stem cells of the intestinal epithelium exhibiting the highest mutation rates and germ-cells in testis exhibited the lowest mutation rates thus far reported. Several mutational signatures were observed among normal cell types. However, most mutations in almost all cell types were due to SBS1 and SBS5, which are likely due to endogenous mutagenic processes. The relative contributions of these signatures differed between cell types, indicating that their rates of generation are, at least partially, independently regulated.

Register on Zoom at https://tinyurl.com/b59rmbk6

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Workshop / Seminar Tue, 30 Nov 2021 16:22:15 -0500 2021-12-06T13:00:00-05:00 2021-12-06T14:00:00-05:00 Off Campus Location Single Cell Spatial Analysis Program (SCSAP) Workshop / Seminar Dr. Raheleh Rahbari, Sanger Institute
Jennifer Nehil (Molson Coors) and Ralph Mertz (Anheuser-Busch InBev) - Flavor Chemistry, Brewing, Performance Metrics, Global Strategy (December 6, 2021 6:00pm) https://events.umich.edu/event/89703 89703-21665063@events.umich.edu Event Begins: Monday, December 6, 2021 6:00pm
Location: Off Campus Location
Organized By: Bio-Tech, Entrepreneurship, and Coding Organization

On Monday, December 06, 2021 @ 6:00PM-7:00PM ET, come virtually listen to Jennifer Nehil (UM MS Chemistry; former R&D Technician and Chemist at BASF; current Brewing Material and Flavor Chemist at Molson Coors) discuss the brewing process, innovation and new product selection, and flavor chemistry, and Ralph Mertz (UM BS Mechanical Engineering; former Chrysler Engineer and Anheuser-Busch IT, Operations & Engineering Manager, and Financial Planning Leader; current Anheuser-Busch Global Vertical Operations Finance and Strategy Senior Director) discuss standard company performance metrics, corporate investments and collaborations, asset management, and a global strategy case study. The event will conclude with an open Q&A.

Anheuser-Busch InBev, or AB InBev, is a publicly-traded multinational drinks conglomerate headquartered in Belgium. It’s the world’s largest beer brewer by both volume and revenue, operating more than 600 beer brands in 150 countries. AB InBev was formed in 2008 through the acquisition of Budweiser brewer Anheuser-Busch by Belgian conglomerate InBev—which is itself a merger of Stella Artois-maker Interbrew and Brazil’s AmBev. In 2015, AB InBev acquired its biggest rival in North America, SABMiller, for $107 billion. The deal required the sale of a number of SABMiller brands, including Miller and Coors, to satisfy antitrust regulators. In recent years, acknowledging the consumer trend away from mass-produced lagers, AB InBev has rapidly acquired U.S. and international craft brewers including Goose Island, Blue Point, and Camden Town Brewery. Some of its popular brands include Budweiser, Michelo, Corona, Bush, and Natural Light. Learn more at https://www.anheuser-busch.com/about.html .

Molson Coors is a publicly-traded multinational drinks conglomerate with twin headquarters in Golden, Colorado, and Montreal, Canada, though officially considered a U.S. firm. In sales, it holds the number one position in Canada, the number two rank in the United Kingdom, and the number three slot in the U.S. Coors Light, the firm's biggest-seller, is the fourth best-selling beer in the United States; Molson Canadian is the best seller in English-speaking Canada; and Carling ranks as the best-selling lager in the United Kingdom. Other key brands include Blue Moon, Dos Equiz, and La Colombe. In 2005, it was formed through a merger of two companies with deep roots — Molson Inc., established in 1786, the oldest brewery in North America; and Adolph Coors, established in 1873 — both of which were still under control of their respective founding families. Following the merger, the Coors and Molson families jointly controlled Molson Coors, each holding one-third of the voting power. Learn more at https://www.molsoncoors.com/about .

This event is co-hosted by two student organizations: business-focused Bio-Tech, Entrepreneurship, and Coding Organization ("BECO") and engineering-focused Food Industry Student Association ("FISA"). Please navigate to BECO's and FISA's respective homepages linked on this post to learn more and join their email lists.

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Workshop / Seminar Fri, 03 Dec 2021 02:20:46 -0500 2021-12-06T18:00:00-05:00 2021-12-06T19:00:00-05:00 Off Campus Location Bio-Tech, Entrepreneurship, and Coding Organization Workshop / Seminar Brewed Beverages
Complex Systems Presents the Annual Nobel Symposium (December 10, 2021 10:00am) https://events.umich.edu/event/89502 89502-21664099@events.umich.edu Event Begins: Friday, December 10, 2021 10:00am
Location: Off Campus Location
Organized By: The Center for the Study of Complex Systems

CLICK TO SEE RECORDINGS OF THE TALKS: https://lsa.umich.edu/cscs/news-events/all-events/event-recordings.html

Registration not required. Free and open to the public. This will be a virtual symposium. This popular annual event features UM faculty experts in each of the six prize fields. Each will present for approximately 25 minutes and then will take some questions. There is a scheduled lunch break. Come to one talk, come to them all.

SCHEDULE
10:00 AM Opening remarks, Marisa Eisenberg, Interim Director of Complex Systems
10:05 AM Physics, Mark Newman, LSA Complex Systems & Physics AND Richard Rood, Engineering & SEAS
10:55 AM Chemistry, Corey Stephenson, LSA Chemistry
11:30 AM Physiology or Medicine, Shawn Xu, Michigan Medicine Molecular and Integrative Physiology & Life Sciences Institute AND Rui Xiao, University of Florida, Center for Smell and Taste (special guest and Michigan Alumni)

12:05 PM Lunch break

1:00 PM Economics: Tanya Rosenblat, School of Information and LSA Economics
1:35 PM Literature: Gaurav Desai, LSA English Language and Literature
*This talk is co-sponsored by the African Studies Center (ii.umich.edu/asc)*
2:10 PM Peace: Lynette Clemetson, Wallace House (Knight-Wallace Fellowships) AND Ron Suny, LSA History & Political Science
3:00 PM Closing remarks

For information on prize winners, please click the Nobel Prize winners link below. Other information on the Nobel Prizes can be found on the website nobelprize.org

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Conference / Symposium Wed, 22 Dec 2021 21:25:28 -0500 2021-12-10T10:00:00-05:00 2021-12-10T15:00:00-05:00 Off Campus Location The Center for the Study of Complex Systems Conference / Symposium Symposium Poster
RNA Faculty Candidate Seminar (December 13, 2021 4:00pm) https://events.umich.edu/event/89524 89524-21663803@events.umich.edu Event Begins: Monday, December 13, 2021 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

In-person/Hybrid seminar co-hosted by the Center for RNA Biomedicine and the Department of Molecular, Cellular, and Developmental Biology

Talk title: “Resolving the localisation and dynamics of mRNA and protein synthesis within neurons”

Keywords: mRNA dynamics, local protein synthesis, neurons, neuronal cell biology, synaptic plasticity, in vivo imaging

If you are having trouble registering, please contact Martina Jerant at mjerant@umich.edu

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Lecture / Discussion Tue, 30 Nov 2021 13:12:23 -0500 2021-12-13T16:00:00-05:00 2021-12-13T17:00:00-05:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion Paul Donlin-Asp, Ph.D.,
RNA Faculty Candidate Seminar (December 20, 2021 4:00pm) https://events.umich.edu/event/89572 89572-21664385@events.umich.edu Event Begins: Monday, December 20, 2021 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

In-person/Hybrid seminar co-hosted by the Center for RNA Biomedicine, the Department of Biological Chemistry and the Department of Biophysics

Talk title: “Modulation of the MALT1 pre-mRNA structure by hnRNP proteins regulates T cell activation”

Key words: pre-mRNA, hnRNP, NMR, SHAPE, structure
Abstract: Alternative splicing is controlled by differential binding of trans-acting RNA binding proteins (RBPs) to cis-regulatory pre-mRNA elements. How pre-mRNA secondary structure affects recognition by RBPs and determines alternative exon usage is poorly understood. The MALT1 paracaspase is a key component of signaling pathways that mediate innate and adaptive immune responses. Alternative splicing of MALT1 exon7 is critical for controlling optimal T cell activation. Here, we demonstrate that MALT1 pre-mRNA splicing depends on RNA structural elements that shield the splice sites of the alternatively spliced exon7. The RBPs hnRNP U and hnRNP L bind comparably and competitively to identical stem-loop RNA structures flanking the 5’ and 3’ splice sites of MALT1 exon7. While hnRNP U stabilizes RNA stem-loop conformations that maintain exon7 skipping, hnRNP L destabilizes these RNA elements to facilitate recruitment of the essential splicing factor U2AF2 to promote exon7 inclusion. This work represents a paradigm for the control of splice site selection by differential RBP binding and modulation of pre-mRNA structure.

If you are having trouble registering, please contact Martina Jerant at mjerant@umich.edu

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Lecture / Discussion Fri, 10 Dec 2021 12:26:46 -0500 2021-12-20T16:00:00-05:00 2021-12-20T17:00:00-05:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion Alisha (Jonesy) Jones, Ph.D.
Mechanisms of CRISPR-mediated immunity and applications beyond editing (January 11, 2022 4:00pm) https://events.umich.edu/event/88986 88986-21659471@events.umich.edu Event Begins: Tuesday, January 11, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Bacteria and archaea have evolved sophisticated adaptive immune systems that rely on CRISPR RNA (crRNA)-guided detection and nuclease-mediated elimination of invading nucleic acids. In this presentation, I will summarize recent bioinformatic, biochemical, and structural studies that explain how conserved DNA sequence motifs that flank CRISPR loci recruit a collection of Cas and non-Cas proteins. Collectively, these proteins kink and twist the host DNA into two consecutive U-shaped structures that specify the location for integration of foreign DNA. Like so many other research projects, the progress of this work has been delayed by the global pandemic. Unexpectedly, our fundamental research on CRISPRs led to the development of a creative new CRISPR-based diagnostic for RNA viruses. I will share recent results and ongoing challenges for rapid and sensitive detection of SARS-CoV-2 using a CRISPR-based detection method.
Blake Wiedenheft (Montana State University)

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Other Tue, 11 Jan 2022 18:15:43 -0500 2022-01-11T16:00:00-05:00 2022-01-11T17:15:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Next Gen Metabolomics Technologies: Broader Coverage, Single Cell, Double Bond Pinpointing, and Spatial Mapping (January 13, 2022 4:00pm) https://events.umich.edu/event/84334 84334-21623357@events.umich.edu Event Begins: Thursday, January 13, 2022 4:00pm
Location: Off Campus Location
Organized By: Department of Chemistry

The highly dynamic nature of metabolites and their abundances makes metabolomics a
powerful endpoint of the ‘omics’ cascade, yielding a molecular profile that is closest to the
physiological phenotype. Metabolomic profiles are therefore sensitive to subtle perturbations
observed in early disease stages or disease progression, which may be difficult to detect at the
proteome or transcriptome levels. Human diseases are multi-factorial in nature, and studying
small parts of their associated molecular changes is generally insufficient for understanding the
full spectrum of disease phenotypes.
The metabolome is the total collection of biologically-active small molecules with molecular
weights lower than about ~1.5 kDa in an organism. This includes endogenous molecules that
are biosynthesized by metabolic networks in “primary metabolism”, specialized “secondary
metabolite” signaling or defense molecules, molecules derived from diet or environmental
exposures (the exposome), and molecules derived from the biosynthetic interactions with
associated microbes (the microbiome). Metabolomics can either be “targeted” to a set of known
compounds, for example certain lipids, or “non-targeted”, which attempts to detect and relatively
quantify as many metabolites as possible.
The vast chemical diversity of the metabolome (lipids, sugars, amino acids, etc.), and its
wide dynamic range (mM to fM) implies that no single analytical method can adequately profile
all metabolites in one metabolomics experiment. Along these lines, the “fusion” of mass
spectrometry (MS) and nuclear magnetic resonance spectroscopy (NMR) is emerging as one of
the most powerful avenues to increase metabolome coverage. Nested separations that work in
a time frame compatible with mass spectrometry, such as those performed by ion mobility, are
also playing a key analytical role in metabolomics as a way of increasing peak capacity, and
identifying metabolites through ion mobility collision cross section measurements. Further,
localization of metabolites at the tissue level with imaging mass spectrometry experiments,
allows linking their abundance with changes observed in biofluids. In this seminar, I will
introduce the typical workflow used in non-targeted metabolomics experiments, describe
potential pitfalls through examples related to our efforts within the Molecular Transducers of
Physical Activity Consortium (MoTrPAC), and showcase the challenges involved in identifying
unknowns with this growing ‘omics approach.

https://umich.zoom.us/j/94087632693?pwd=bW5qMFQ0ZmRHTEdZZTNVUkt2Mmk1UT09
Passcode Fernandez



Facundo Fernandez (Georgia Institute of Technology)

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Other Thu, 13 Jan 2022 18:15:43 -0500 2022-01-13T16:00:00-05:00 2022-01-13T17:30:00-05:00 Off Campus Location Department of Chemistry Other
Biophysics in industry: Real-time measurement and manipulation of single-molecule interactions: from DNA-binding proteins to biomolecular condensates (January 14, 2022 12:00pm) https://events.umich.edu/event/90313 90313-21670330@events.umich.edu Event Begins: Friday, January 14, 2022 12:00pm
Location: Off Campus Location
Organized By: LSA Biophysics

Biological processes emerge from mechanisms at the molecular scale. While biophysical techniques (e.g., X-ray crystallography, cryoEM) with bulk biochemical assays (e.g., enzymatic reactions, fluorescent reporters) have helped to better understand emergent structure-function relationships, the complete picture of molecular-scale mechanisms is often missed. In addition, the existing techniques often do not provide tools to observe and manipulate a biological system simultaneously and understand mechanisms from the molecular to the cellular level. In this talk, I will introduce a single-molecule tool, the C-Trap, which enables users to observe and manipulate biological systems in real-time. This technology combines two Nobel prize-winning ideas (optical tweezers and super-resolution STED microscopy), integrated with easy-to-use microfluidics, that allows users to perform single-molecule studies on a broad range of biological systems. I will present some case studies to highlight the role of C-trap in looking at DNA/RNA-proteins interactions, proteins/RNA-structure dynamics, and nucleic acid/protein condensates. The presented case studies and workflows serve as a framework for measuring and visualizing complex and dynamic biological systems, that would be extremely challenging to study using conventional biophysical techniques.

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Workshop / Seminar Fri, 07 Jan 2022 14:29:24 -0500 2022-01-14T12:00:00-05:00 2022-01-14T13:00:00-05:00 Off Campus Location LSA Biophysics Workshop / Seminar
Advancing Climate Justice & Environmental Health: people-centered approaches to transformational research (January 18, 2022 12:00pm) https://events.umich.edu/event/90764 90764-21673518@events.umich.edu Event Begins: Tuesday, January 18, 2022 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

REGISTRATION REQUIRED
https://umich.zoom.us/webinar/register/WN_qa4rv9J3SZehApoPqRPIVw
A life-long learner and advocate, Dr. Jalonne L. White-Newsome founded Empowering a Green Environment and Economy, LLC, a strategic consulting firm, with the mission of transforming communities through the development of people-centered solutions. She serves a diverse set of clients with forward-thinking and intersectional approaches to tackle issues such as climate change, public health, environmental injustice, and advancing racial equity.

Dr. White-Newsome ha has multi-sector experience having worked in environmental philanthropy, state government, non-profit, grassroots, academia and private industry. Most notably, she created and implemented the transformational Climate Resilient and Equitable Water Systems (CREWS) Initiative at the Kresge Foundation as a Senior Program Officer; she was the first Director of WE ACT for Environmental Justice’s federal policy office in Washington, DC; and, her doctoral research illuminated the impact of climate change & extreme heat on the low-income, elderly in Detroit, and is still referenced to drive public health interventions.

A native of Detroit, Jalonne earned a Ph.D. in environmental health sciences from the University of Michigan School of Public Health, a master’s degree in environmental engineering from Southern Methodist University, a bachelor’s degree in chemical engineering from Northwestern University, and her certificate in Diversity and Inclusion from Cornell University.

Jalonne serves on multiple national and local academic, non-profit and for-profit Boards. She is a Lecturer at The George Washington University Milken Institute School of Public Health, a lifetime member of Delta Sigma Theta Sorority, Inc., and the proud mom of Arielle and Jeannelyn.

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Lecture / Discussion Mon, 10 Jan 2022 16:24:08 -0500 2022-01-18T12:00:00-05:00 2022-01-18T12:50:00-05:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Jan 18 Advancing Climate Justice & Environmental Health
LHS Collaboratory (January 18, 2022 12:00pm) https://events.umich.edu/event/89940 89940-21666535@events.umich.edu Event Begins: Tuesday, January 18, 2022 12:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

This presentation will explore how Big Data Science and Informatics research can overcome deficiencies within the electronic health record and optimize real world data collection. We will discuss examples of how standardized nomenclature integrated into clinical workflow can enable statistical AI methods to advance clinical decision support and improve outcome models. Our successes in radiation oncology come from single multi-institutional, multi-national and multi-professional society collaboration.

Presenters:
Charles Mayo, PhD
Professor
Director of Radiation Oncology Informatics and Analytics
Department of Radiation Oncology
University of Michigan Medical School

Michelle Mierzwa, MD
Associate Professor
Associate Chair of Clinical Research
Co-Chair of Head and Neck Clinical Trials
Department of Radiation Oncology
University of Michigan Medical School

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Lecture / Discussion Tue, 11 Jan 2022 15:56:37 -0500 2022-01-18T12:00:00-05:00 2022-01-18T13:30:00-05:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion Collaboratory logo
Structure-Function Relationships of Single Fluorescent Macromolecules (January 20, 2022 4:00pm) https://events.umich.edu/event/88613 88613-21656201@events.umich.edu Event Begins: Thursday, January 20, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

When chemical reactivity is measured for a series of systematically related molecules, a structure-function relationship can be derived that summarizes the effect of the perturbation. This seminar will develop the idea of studying chemistry with single molecule structure-function relationships. In our implementation, optical tweezers are used to isolate a tethered single molecule and apply a force bias to create sub-ensembles of well-defined extension. For fluorescent molecules, the intrinsic optical emission can provide a probe of function. Ongoing research will be discussed, including an investigation into the green fluorescent family of proteins. These proteins share a common chromophore capable of a diverse range of photochemistries (electron transfer, proton transfer, isomerization, oxidative addition) whose reactivity is determined by subtle environmental changes.



Ziad Ganim (Yale University)

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Other Thu, 20 Jan 2022 18:15:29 -0500 2022-01-20T16:00:00-05:00 2022-01-20T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Grad School Interviews Office Hour (January 21, 2022 10:00am) https://events.umich.edu/event/91167 91167-21677027@events.umich.edu Event Begins: Friday, January 21, 2022 10:00am
Location: Off Campus Location
Organized By: Futures in Research, Science, Teaching - FIRST

If you would like to ask current biology grad students about what interviewing at different grad programs is like, or practice interviewing yourself, please stop by.

Zoom link: https://umich.zoom.us/j/99108550897

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Workshop / Seminar Tue, 18 Jan 2022 11:11:32 -0500 2022-01-21T10:00:00-05:00 2022-01-21T11:00:00-05:00 Off Campus Location Futures in Research, Science, Teaching - FIRST Workshop / Seminar FIRST Logo with the name made out of chromosomes separating during mitosis.
TBA (January 21, 2022 12:00pm) https://events.umich.edu/event/90314 90314-21670331@events.umich.edu Event Begins: Friday, January 21, 2022 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

TBA

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Workshop / Seminar Mon, 03 Jan 2022 09:18:32 -0500 2022-01-21T12:00:00-05:00 2022-01-21T13:00:00-05:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
TBA (January 27, 2022 4:00pm) https://events.umich.edu/event/86100 86100-21631484@events.umich.edu Event Begins: Thursday, January 27, 2022 4:00pm
Location: Off Campus Location
Organized By: Department of Chemistry

Analytical
Tim Bertram (University of Wisconsin)

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Other Tue, 11 Jan 2022 12:15:27 -0500 2022-01-27T16:00:00-05:00 2022-01-27T17:30:00-05:00 Off Campus Location Department of Chemistry Other
RNA Faculty Candidate Seminar (January 31, 2022 4:00pm) https://events.umich.edu/event/89608 89608-21664520@events.umich.edu Event Begins: Monday, January 31, 2022 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

In-person/Hybrid seminar co-hosted by the Center for RNA Biomedicine, the Department of Biological Chemistry and the Department of Biophysics

Talk title: “The scanning mechanism of mRNA translation initiation in humans”

Keywords: mRNA, translation, ribosome, helicase

Abstract: Decoding the genetic information into protein is fundamental for all kingdoms of life. It requires precise mechanisms to transcribe the DNA into mRNA, which then can be translated by the ribosome to produce proteins. Translation initiation of eukaryotic mRNAs is a dynamic process regulated by over a dozen protein eukaryotic initiation factors (eIFs). This process starts with the binding of eukaryotic initiation factors eIF1, eIF1A, eIF3, eIF5, and a ternary complex of eIF2–GTP–tRNAiMet (TC) to the 40S small ribosomal subunit, forming the 43S preinitiation complex (43S PIC). Once assembled, the 43S PIC is recruited to the 5′ untranslated region (UTR) of mRNA by the multifactor cap-binding complex eIF4F, forming the 48S initiation complex (48S). The 48S then scans along the 5′ UTR mRNA to locate a start codon. The eIF4F binding site in the 48S and how mRNA is inserted into the mRNA channel in the 40S small ribosomal subunit remained unknown. To gain insights into the molecular mechanism underlining the assembly of the 48S, we used cryo-electron microscopy to determine the structure of a reconstituted human 48S. The structure sheds light on the early events of translation initiation complex assembly, including how eIF4F interacts with the 43S during the scanning process.

If you are having trouble registering, please contact Martina Jerant at mjerant@umich.edu

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Lecture / Discussion Tue, 04 Jan 2022 11:24:42 -0500 2022-01-31T16:00:00-05:00 2022-01-31T17:00:00-05:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion Jailson (Jay) Brito Querido, MRC Laboratory of Molecular Biology
Bright chiral light from small molecules (February 1, 2022 4:00pm) https://events.umich.edu/event/91340 91340-21678329@events.umich.edu Event Begins: Tuesday, February 1, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Inorganic
Gael Ung (University of Connecticut)

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Other Tue, 01 Feb 2022 18:15:33 -0500 2022-02-01T16:00:00-05:00 2022-02-01T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Graham Sustainability Scholars Info Session (February 2, 2022 5:30pm) https://events.umich.edu/event/91870 91870-21683698@events.umich.edu Event Begins: Wednesday, February 2, 2022 5:30pm
Location: Off Campus Location
Organized By: Graham Sustainability Institute

Join us on Wednesday, February 2, at 5:30 p.m. for an information session on the Graham Scholars Program! This session will walk you through the process and what you can expect from the program, with time set aside to answer all your questions. Pre-register now or join using the Zoom link here.

Graham Sustainability Scholars form a tight-knit cohort supported, challenged, and inspired by each other, as well as by program partners and advisors.

Through rich co-curricular experiences, Graham Scholars learn to incorporate sustainability into the campus, their lifestyle, their discipline, and the broader community. They have access to professional development and other resources that are designed to enhance academic courses and help build resumes.

Program participants begin the in fall of their junior year and complete the program in the fall of their senior year. Their primary focus is managing an interdisciplinary project with a local organization. Through training in project management and community engagement, participants hone leadership, critical thinking, and problem-solving skills—all tools needed to be a leader in any organization.

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Presentation Wed, 02 Feb 2022 12:42:05 -0500 2022-02-02T17:30:00-05:00 2022-02-02T18:30:00-05:00 Off Campus Location Graham Sustainability Institute Presentation Graham Sustainability Scholars Info Session
Graham Sustainability Scholars Info Session (February 2, 2022 5:30pm) https://events.umich.edu/event/91870 91870-21683699@events.umich.edu Event Begins: Wednesday, February 2, 2022 5:30pm
Location: Off Campus Location
Organized By: Graham Sustainability Institute

Join us on Wednesday, February 2, at 5:30 p.m. for an information session on the Graham Scholars Program! This session will walk you through the process and what you can expect from the program, with time set aside to answer all your questions. Pre-register now or join using the Zoom link here.

Graham Sustainability Scholars form a tight-knit cohort supported, challenged, and inspired by each other, as well as by program partners and advisors.

Through rich co-curricular experiences, Graham Scholars learn to incorporate sustainability into the campus, their lifestyle, their discipline, and the broader community. They have access to professional development and other resources that are designed to enhance academic courses and help build resumes.

Program participants begin the in fall of their junior year and complete the program in the fall of their senior year. Their primary focus is managing an interdisciplinary project with a local organization. Through training in project management and community engagement, participants hone leadership, critical thinking, and problem-solving skills—all tools needed to be a leader in any organization.

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Presentation Wed, 02 Feb 2022 12:42:05 -0500 2022-02-02T17:30:00-05:00 2022-02-02T18:30:00-05:00 Off Campus Location Graham Sustainability Institute Presentation Graham Sustainability Scholars Info Session
Learning Health Systems: A Pathway to Sustainable Health Improvement (February 3, 2022 12:00pm) https://events.umich.edu/event/91725 91725-21682582@events.umich.edu Event Begins: Thursday, February 3, 2022 12:00pm
Location:
Organized By: Office of Research School of Dentistry

Charles Friedman is the Josiah Macy Jr. Professor of Medical Education and Chair of the Department of Learning Health Sciences at the University of Michigan Medical School. In recent years, he has focused his academic interests and activities on the concept of Learning Health Systems, and the socio-technical infrastructure required to sustain them. He is editor-in-chief of the open-access journal Learning Health Systems and co-chair of the movement to Mobilize Computable Biomedical Knowledge.

He was recently awarded an honorary doctorate by the University of Lucerne in Switzerland for his contributions to the science of Learning Health Systems.
Prior to coming to Michigan, Friedman held executive positions at the Office of the National Coordinator for Health IT (ONC) in the U.S. Department of Health and Human Services. Immediately prior to his work in the government, Dr. Friedman was Associate Vice Chancellor for Biomedical Informatics, and Founding Director of the Center for Biomedical Informatics at the University of Pittsburgh.

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Presentation Mon, 31 Jan 2022 11:39:40 -0500 2022-02-03T12:00:00-05:00 2022-02-03T13:00:00-05:00 Office of Research School of Dentistry Presentation Charles P. Friedman, PhD
Dark Matter of the Human Genome (February 7, 2022 4:00pm) https://events.umich.edu/event/82493 82493-21110099@events.umich.edu Event Begins: Monday, February 7, 2022 4:00pm
Location: Off Campus Location
Organized By: Department of Chemistry

Analytical
Sarah Slavoff (Yale University)

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Other Mon, 07 Feb 2022 18:15:27 -0500 2022-02-07T16:00:00-05:00 2022-02-07T17:30:00-05:00 Off Campus Location Department of Chemistry Other
Long-term Air Pollution and Incident Dementia in U.S. (February 8, 2022 12:00pm) https://events.umich.edu/event/91240 91240-21677512@events.umich.edu Event Begins: Tuesday, February 8, 2022 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

REGISTRATION REQUIRED
https://umich.zoom.us/webinar/register/WN_d_LFab2xTmmTjHuJsfZLmg

Liuhua Shi, ScD, is Assistant Professor of Environmental Health in the Rollins School of Public Health at Emory University.

Dr. Shi's research focuses on employing massive datasets, including satellite-retrieved high resolution exposures and health data, to investigate how climate change and air pollution influence seniors' health.

More specifically, her research is focused on:
1. application of remote sensing in environmental exposure modeling (e.g., predicting high-resolution PM2.5, ozone, NO2, and temperature);
2. estimating the health consequences of exposure to air pollution and climate change;
3. estimating the link between climate change and air quality, and the mediated health impacts;
4. estimating the joint and independent health effects of air pollutant mixtures;
5. statistical modeling, e.g., causal modeling and big data approach.

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Lecture / Discussion Wed, 19 Jan 2022 13:12:34 -0500 2022-02-08T12:00:00-05:00 2022-02-08T12:50:00-05:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Air pollution and dementia
Modeling Enzymatic Reactivity with Copper Coordination Complexes (February 8, 2022 4:00pm) https://events.umich.edu/event/84411 84411-21623897@events.umich.edu Event Begins: Tuesday, February 8, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Synthetic models of enzyme intermediates play an important role in evaluating mechanistic hypotheses for critical biochemical reactions. In the first part of my talk, I will present the synthesis of dicopper coordination complexes as models to understand the reactivity of NO and NO2- at copper enzymes. We discovered that dicopper complex could activate NO or nitrite to generate a unique dicopper (II,III) oxo nitrosyl species [Cu2(μ-O)(μ-NO)]2+, which exhibits oxidative and nitrosative reactivity. This new mode of reactivity has important implications in how Nature employs NO and nitrite as electron acceptors for hydrocarbon oxidation. In the second part of my talk, I will discuss how synthetic models of monocopper oxygenases can be applied in the synthesis of pharmaceutically relevant organic molecules. Inspired by lytic polysaccharide monooxygenases, we develop a general Cu(II)/Cu(III) platform to activate simple nucleophiles (Nu) toward C-H functionalization. Oxidation of Cu(II)-Nu to Cu(III)-Nu endows the Nu moiety with hydrogen atom transfer and radical capture reactivity. Building on this platform, we have established a catalytic C-H fluorination method that selectively produces monofluorinated products in an undivided electrochemical cell at room temperature.

Shiyu Zhang (Ohio State University)

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Other Tue, 08 Feb 2022 18:15:39 -0500 2022-02-08T16:00:00-05:00 2022-02-08T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Craniofacial Regeneration, Stem Cells, and Clinical Cell Therapy...Where are we now? (February 10, 2022 12:00pm) https://events.umich.edu/event/91853 91853-21683555@events.umich.edu Event Begins: Thursday, February 10, 2022 12:00pm
Location:
Organized By: Office of Research School of Dentistry

Major M. Ash Collegiate Professor of Periodontics
Department of Periodontics and Oral Medicine
University of Michigan

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Presentation Wed, 02 Feb 2022 08:43:33 -0500 2022-02-10T12:00:00-05:00 2022-02-10T13:00:00-05:00 Office of Research School of Dentistry Presentation Darnell Kaigler, Jr., D.D.S, M.S., Ph.D.
High Sensitivity Microfluidic Measurements of Biomolecules (February 10, 2022 4:00pm) https://events.umich.edu/event/90950 90950-21675088@events.umich.edu Event Begins: Thursday, February 10, 2022 4:00pm
Location: Off Campus Location
Organized By: Department of Chemistry

Microfluidic analyses offer numerous benefits compared to traditional bioanalytical techniques. These miniaturized systems afford faster analysis times, require less sample volume, and can integrate sample preparation and analysis into a single platform. Our laboratory has harnessed these benefits to develop high sensitivity gel electrophoresis and digital PCR methods to measure diverse biological analytes including proteins, nucleic acids, small molecules, and cells. Our electrophoresis project utilizes thermally responsive polymers as a gel matrix. Temperature is adjusted to tune analytical performance and achieve preconcentration and separation of biomolecules and cells. Our digital PCR project integrates detection of proteins and nucleic acids. Target analytes are measured from individual biocomplexes with single-molecule sensitivity. The innovative analytical strategies developed in our laboratory enhance measurement capabilities to facilitate biological research.
Tom Linz (Wayne State University)

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Other Thu, 10 Feb 2022 18:15:31 -0500 2022-02-10T16:00:00-05:00 2022-02-10T17:30:00-05:00 Off Campus Location Department of Chemistry Other
TBA (February 11, 2022 12:00pm) https://events.umich.edu/event/90315 90315-21670332@events.umich.edu Event Begins: Friday, February 11, 2022 12:00pm
Location: Off Campus Location
Organized By: LSA Biophysics

TBA

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Workshop / Seminar Mon, 03 Jan 2022 09:17:22 -0500 2022-02-11T12:00:00-05:00 2022-02-11T13:00:00-05:00 Off Campus Location LSA Biophysics Workshop / Seminar
Oral Health for All: Opportunities for Improvement and Understanding (February 17, 2022 1:00pm) https://events.umich.edu/event/91753 91753-21683050@events.umich.edu Event Begins: Thursday, February 17, 2022 1:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

Dr. Jennifer Webster-Cyriaque is the deputy director of National Institute of Dental and Craniofacial Research, National Institutes of Health. An accomplished clinician, researcher, and leader, Dr. Webster-Cyriaque had previously served as a faculty member at the University of North Carolina (UNC) schools of dentistry and medicine for more than two decades.

As a tenured full professor at UNC, Dr. Webster-Cyriaque also served as the attending on clinical service at the UNC Hospital’s dental clinic. While there, she led research into a potential etiologic agent for salivary gland disease in patients living with HIV, assessed the oral microbiome and its implications for cancer-causing viruses, and studied the impact of the oral microbiome and oral health on HIV outcomes.

In addition to her research, Dr. Webster-Cyriaque has held leadership roles as the chair/vice chair of the Oral HIV/AIDS Research Alliance, as research director at the National Dental Association Foundation, as director of postdoctoral CTSA training, along with multiple roles within the American Association for Dental, Oral, and Craniofacial Research and the International Association for Dental Research. Since 2004, she has led the UNC Malawi project and provided assistance in founding Malawi’s first dental school in 2019. Dr. Webster-Cyriaque earned her PhD in microbiology/immunology from the University of North Carolina-Chapel Hill in 1998, her DDS from SUNY Buffalo in 1992, and her BA in biology and interdisciplinary social science from SUNY Buffalo in 1988.

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Presentation Tue, 01 Feb 2022 08:51:49 -0500 2022-02-17T13:00:00-05:00 2022-02-17T14:00:00-05:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Presentation Jennifer Webster-Cyriaque, DDS, PhD
From Thermodynamics to Spin Trapping: Challenges across the Periodic Table (February 17, 2022 4:00pm) https://events.umich.edu/event/91341 91341-21678330@events.umich.edu Event Begins: Thursday, February 17, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Physical
Angela Wilson (Michigan State University)

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Other Thu, 17 Feb 2022 18:15:29 -0500 2022-02-17T16:00:00-05:00 2022-02-17T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
SCSAP Monthly Seminar Series (February 21, 2022 1:00pm) https://events.umich.edu/event/92429 92429-21691399@events.umich.edu Event Begins: Monday, February 21, 2022 1:00pm
Location: Off Campus Location
Organized By: Single Cell Spatial Analysis Program (SCSAP)

Join us on Monday to hear about IsoPlexis’ product suite capabilities and how functional phenotyping is addressing urgent challenges central to unlocking the next stage of personalized cancer immunotherapies and vaccines related to immunological mechanisms in infectious disease. With single-cell proteomics barcoding and detection of a full range of cytokines (30+) per single-cell across thousands of single-cells, the IsoLight platform is showing the unique value of resolving the heterogeneity of a variety of immune cell types, elucidating key pre-clinical translational biomarkers to accelerate research and discovery.
JOIN US AT THE END OF THE TECH TALK TO LEARN ABOUT AN EXCITING GRANT PROGRAM SPONSORED BY THE UNIVERSITY OF MICHIGAN
SINGLE CELL SPATIAL ANALYSIS PROGRAM
Discussion topics include:
• Reveal the functional mechanism of immune activation in a novel agonist combination with adoptive cell therapy
• Uncover the role of TILs within Ipi/Nivo checkpoint combination and reveal the biological drivers of patient response
• Identify the unique polyfunctional monocyte cell types that drive tumor suppression
• Understand the functional differences of tumor antigen potency in bispecifics
• Identify functional immune mechanism CD8 T cell response for infectious diseases
• And other single-cell functional proteomics cases

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Workshop / Seminar Wed, 16 Feb 2022 11:53:04 -0500 2022-02-21T13:00:00-05:00 2022-02-21T14:00:00-05:00 Off Campus Location Single Cell Spatial Analysis Program (SCSAP) Workshop / Seminar Isoplexis
Activity-based chemical probes for RNA modifying enzymes (February 22, 2022 4:00pm) https://events.umich.edu/event/88867 88867-21658706@events.umich.edu Event Begins: Tuesday, February 22, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Epitranscriptomic RNA modifications can regulate RNA activity, however there remains a major gap in our understanding of the scope of RNA chemistry present in biological systems, the enzymes responsible for regulating modification levels, and the ultimate function of these modifications in biological processes. To address this gap, our group has developed RNA-mediated activity-based protein profiling (RNABPP), a chemoproteomic strategy relying upon metabolic RNA labeling with modified nucleoside probes, RNA-protein enrichment, and quantitative proteomics. This lecture will discuss the application of RNABPP with fluoropyrimidine nucleosides in human cells in order to profile diverse families of RNA modifying enzymes including m5C and m5U methyltranferases, as well as dihydrouridine synthase (DUS) enzymes. Time allowing, I will also discuss new developments in RNA metabolic labeling technology.







Ralph Kleiner (Princeton University)

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Other Tue, 22 Feb 2022 18:15:39 -0500 2022-02-22T16:00:00-05:00 2022-02-22T17:15:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Weekly Seminar for DCMB / CCMB (February 23, 2022 4:00pm) https://events.umich.edu/event/92060 92060-21686457@events.umich.edu Event Begins: Wednesday, February 23, 2022 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

In the Peixoto lab we use genomic approaches to understand gene expression and its epigenetic regulation in response to learning and sleep deprivation, and its alteration in autism spectrum disorders. This requires combining behavioral paradigms in mice, molecular biology and the analysis of high-throughput data in the brain in vivo. It also requires using the right data analysis tools to be able to capture the effect of learning or sleep in the context of an ever-active brain. In this talk we will discuss the effects of learning on chromatin accessibility and the effects of sleep loss in gene expression, with an emphasis on how data analysis influences our ability to detect novel and reproducible biology.

Short bio:

Lucia Peixoto received her bachelor’s degree in Biochemistry from the Universidad de la Republica in her native Uruguay in 2002. She subsequently earned her Ph.D. at The University of Pennsylvania under the mentorship of Dr. David S. Roos, using genomic and computational biology approaches to understand host-pathogen interactions. She completed her postdoctoral training in Neuroscience with Dr. Ted Abel at The University of Pennsylvania in 2015. During her fellowship, she was also a trainee at the Training Program in Neurodevelopmental disabilities at the Children’s Hospital of Philadelphia. As a trainee at CHOP, she completed a clinical internship at the Center for Autism Research under the supervision of Dr. Robert Schultz. She became an Assistant Professor at Washington State University in 2015 and has since been recognized with a K01 Early Career Faculty award from NIH/NINDS and a pilot award from the Simons Foundation Autism Research Initiative. She is also a member of the board of directors of the International Society of computational biology (ISCB) and cochair the Equity, Diversity and Inclusion committee of ISCB. Her lab uses behavior, electrophysiology, molecular biology and genomic approaches to understand how sleep and learning modulate transcription and how this may be altered in Autism Spectrum Disorders.

Zoom livestream link: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Workshop / Seminar Mon, 07 Feb 2022 14:54:44 -0500 2022-02-23T16:00:00-05:00 2022-02-23T17:00:00-05:00 Off Campus Location DCMB Seminar Series Workshop / Seminar
Synthesis and Photophysics of First-Row Transition Metal Oxide Semiconductor Nanomaterials (February 24, 2022 12:00am) https://events.umich.edu/event/91600 91600-21681018@events.umich.edu Event Begins: Thursday, February 24, 2022 12:00am
Location: Off Campus Location
Organized By: Department of Chemistry

Metal oxide nanomaterials based on first-row transition metals are particularly attractive for applications in renewable energy technologies because (i) they absorb visible light, (ii) they are thermodynamically capable of performing desired photoredox chemistry, such as water oxidation and reduction of protons or carbon dioxide, and (iii) they are composed of inexpensive, earth-abundant, nontoxic elements. Complete synthetic control of the size, shape, and crystal structure of first-row transition metal oxide nanomaterials combined with a thorough understanding of their electrochemical and photophysical behavior is required to optimize their function in photocatalytic applications. This talk focuses on recent results from two ongoing areas in our group. The first area investigates the role of organic ligands, solvent, and precursor chemistry in controlling the size, shape, composition, and crystal phase of first-row transition metal oxide nanocrystals synthesized at elevated pressure using solvothermal methods. The second project combines thermal difference and resonance Raman spectroscopy with DFT calculations to explore the dynamics and electronic structure of photoexcited states of nanostructured thin films of alpha-Fe2O3 (hematite). These data indicate that polarons (quasiparticles that comprise a charge-carrier self-trapped in a potential well formed by nuclear displacements of the surrounding lattice) form directly upon photoexcitation of a thermally activated lattice. This newly recognized mechanism of photoinduced polaron formation has significant implications for the use of hematite in light-conversion technologies such as photoelectrochemical water oxidation.
Kathryn Knowles (University of Rochester)

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Other Thu, 24 Feb 2022 18:15:22 -0500 2022-02-24T00:00:00-05:00 2022-02-24T00:00:00-05:00 Off Campus Location Department of Chemistry Other
LHS Collaboratory (February 24, 2022 12:00pm) https://events.umich.edu/event/90079 90079-21667713@events.umich.edu Event Begins: Thursday, February 24, 2022 12:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

The session will describe the landscape history, current status, and future of federated health data networks that are used to support a Learning Health System. Dr. Brown will describe the creation, infrastructure, operation, and uses of several networks from the perspective of a network coordinating center. Dr. Harris will describe insights from participating in multiple networks as a network partner, including infrastructure, governance, and operational lessons learned.

Presenters:
Jeffrey Brown, PhD
Dr. Brown is the inventor of PopMedNet, an open-source software platform that facilitates creation and operation of distributed health data networks.

Marcelline Harris, Ph.D., RN, FACMI
Associate Professor Emerita
Department of Systems, Populations and Leadership
University of Michigan School of Nursing

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Lecture / Discussion Sat, 29 Jan 2022 11:26:41 -0500 2022-02-24T12:00:00-05:00 2022-02-24T13:30:00-05:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion Collaboratory logo
Exploration of Photoresponsive Materials (March 8, 2022 4:00pm) https://events.umich.edu/event/91344 91344-21678333@events.umich.edu Event Begins: Tuesday, March 8, 2022 4:00pm
Location: Off Campus Location
Organized By: Department of Chemistry

Photons have multiple enabling advantages to control stimuli-responsive materials. In this seminar, I will discuss our groups effort to design and develop a new class of negative photochromic molecules termed DASA, their incorporation into materials and subsequent effort to unlock their potential to convert light directly into mechanical work.




Javier Read de Alaniz (UC Santa Barbara)

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Other Tue, 08 Mar 2022 18:15:27 -0500 2022-03-08T16:00:00-05:00 2022-03-08T17:30:00-05:00 Off Campus Location Department of Chemistry Other
Making TSCA Work: Demystifying the Risk Assessment Process (March 8, 2022 4:00pm) https://events.umich.edu/event/92216 92216-21688196@events.umich.edu Event Begins: Tuesday, March 8, 2022 4:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

REGISTRATION REQUIRED
https://umich.zoom.us/webinar/register/WN_K4BCE3rXSIuGYHsJ3n5LFw

The University of Michigan M-LEEaD Center is co-sponsoring a virtual event to discuss the bipartisan legislation called the Frank R. Lautenberg Chemical Safety for the 21st Century Act. This reform law was designed to modernize the Toxic Substances Control Act (TSCA) and U.S. industrial chemical policy to promote health, but has it lived up to its promise?

Toxic chemicals can harm our health as these substances are present in everyday products (e.g., cleaning products, cookware, housing and infrastructure materials, bedding, toys). Unlike pharmaceuticals, industrial and commercial chemicals are rarely tested for safety before they reach the U.S. market. However, amended TSCA gave the U.S. Environmental Protection Agency new authorities to require manufacturers provide the data needed for risk assessments. People expect the outcomes of implementing our environmental laws to be equitable health protection for the public from environmental harms. Yet, key components of risk evaluations seem complex and thus inaccessible to the public. Our goal is to demystify the process of assessing the science to move toward evidence-based safeguards communities want for public health.

Our virtual event will examine key issues from a series of recent scientific workshops. We will present a case study of applying the principles to treating cancer and non-cancer health effects in similar manners in the risk assessment for the chemical perchloroethylene (PCE). We will explore the use of probabilistic assessments in TSCA risk evaluations. The amended TSCA gave the U.S. Environmental Protection Agency new requirements and authorities. The public health impact points to the need for the U.S. EPA to fully use its new powers to evaluate all risks from hazardous chemicals and set policies which protect health and are accountable to high-risk communities. Preventive actions are urgently needed.

Speakers and discussants include:
* Regina Strong (Office of the Environmental Justice Public Advocate for the Michigan Department of Environment, Great Lakes and Energy (EGLE));
* Wilma Subra (Technical Director, Louisiana Environmental Action Network);
* Wendy Heiger-Bernays, PhD (Clinical Professor, Department of Environmental Health, Boston University);
* Gary Ginsberg, PhD (New York Dept of Health, Center for Environmental Health (CEH));
* Chanese Forté, PhD, MPH (Assistant Research Scientist, University of California, San Francisco, Program on Reproductive Health and the Environment);
* Greylin Nielsen, MPH (Doctoral student, Department of Environmental Health, Boston University School of Public Health).

REGISTRATION REQUIRED
https://umich.zoom.us/webinar/register/WN_K4BCE3rXSIuGYHsJ3n5LFw

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Workshop / Seminar Mon, 07 Mar 2022 12:42:08 -0500 2022-03-08T16:00:00-05:00 2022-03-08T18:00:00-05:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Workshop / Seminar Making TSCA Work
Data Science in Health Disparities Research Symposium (March 11, 2022 9:00am) https://events.umich.edu/event/91976 91976-21684826@events.umich.edu Event Begins: Friday, March 11, 2022 9:00am
Location: Palmer Commons
Organized By: DCMB Seminar Series

Additional speakers on the topics of:

How data science can be used to understand racial health disparities

How data science with biased data exacerbates health disparities

Lunch and discussion sessions following the talks.

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Workshop / Seminar Mon, 07 Feb 2022 10:37:38 -0500 2022-03-11T09:00:00-05:00 2022-03-11T15:00:00-05:00 Palmer Commons DCMB Seminar Series Workshop / Seminar
Integrating intersectionality into Environmental Health Sciences (March 15, 2022 12:00pm) https://events.umich.edu/event/92997 92997-21698985@events.umich.edu Event Begins: Tuesday, March 15, 2022 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

*Registered required.

Ami Zota, ScD, MS, is an Associate Professor in the Department of Environmental & Occupational Health at George Washington University's Milken School of Public Health. Dr. Zota’s work seeks to secure environmental justice and improve health equity through advancements in science, policy, and clinical practice. Her research identifies novel pathways linking social disparities, environmental exposures, and reproductive and children’s health.

The environmental research seminar series is organized by the Integrated Health Sciences Core of the Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD). More information about M-LEEaD and upcoming events can be found here: http://mleead.umich.edu/index.php

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Lecture / Discussion Fri, 04 Mar 2022 09:34:10 -0500 2022-03-15T12:00:00-04:00 2022-03-15T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Integrating intersectionality into Environmental Health Sciences
Establishing Compositional Control in 2D and 3D Metal Sulfide Electrocatalysts to Drive CO2 and CO Conversion to Alcohols (March 15, 2022 4:00pm) https://events.umich.edu/event/84371 84371-21623617@events.umich.edu Event Begins: Tuesday, March 15, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Development of materials that address the growing dichotomy of simultaneously increasing energy demands and carbon emissions is an imperative that has progressively affected energy-related research efforts. An emerging technical avenue in this area is the conversion of vastly abundant renewable energy sources that can be harnessed and directed towards synthesis of traditionally fossil fuel-based products from atmospheric feedstocks like CO2. To this end, our work establishes structure—function relationships for materials within the versatile classes of MX2 (M = Mo, W; X = S, Se) and Chevrel-Phase (CP) MyMo6X8 (M = alkali, alkaline, transition or post-transition metal; y = 0-4; X = S, Se, Te) chalcogenides. The molybdenum sulfide structures from both families exhibit exceptional promise as CO2R catalysts. Furthermore, we have identified the CP catalyst framework as being selective towards the electrochemical reduction of CO2 and CO to methanol (only major liquid-phase product) under applied potentials as mild as -0.4 V vs RHE. Reactivity toward electrochemical reduction of CO2 and CO to methanol is correlated with increased population of chalcogen states, as confirmed via X-Ray Absorption Spectroscopy. Overall, this work seeks to unravel optimally reactive novel small-molecule reduction catalyst compositions.
Jesus Velazquez (University of California, Davis)

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Other Tue, 15 Mar 2022 18:15:27 -0400 2022-03-15T16:00:00-04:00 2022-03-15T17:15:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
“The Salivary Glands: Robust Sites for Infection and Transmission of SARS-CoV-2” (March 17, 2022 12:00pm) https://events.umich.edu/event/92751 92751-21695193@events.umich.edu Event Begins: Thursday, March 17, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

BIOGRAPHY
Born: August 3rd, 1981, Defiance, Ohio, United States of America

LICENSES & CERTIFICATIONS
Diplomate, Oral and Maxillofacial Pathology – American Board of Oral and Maxillofacial Pathology
Dental License(s) – Unrestricted Dental License, Commonwealth of Pennsylvania, DS039850
DEA Registration – US Department of Justice
CPR Certification – American Red Cross

HONORS, AWARDS, & NOTEWORTHY INVITED TALKS.
2021 American College of Rheumatology Convergence, Invited Speaker, “Epigenetics of Sjogren’s Syndrome.” November 2021. >600 Attendees/Views.

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Lecture / Discussion Tue, 01 Mar 2022 11:08:51 -0500 2022-03-17T12:00:00-04:00 2022-03-17T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Lecture / Discussion Blake Warner, DDS, PhD, MPH Assistant Clinical Investigator Chief of the Salivary Disorders Unit and the Sjogren’s Syndrome Clinic NIH National Institute of Dental and Craniofacial Research
3rd Year Graduate Student Seminars (March 21, 2022 12:00am) https://events.umich.edu/event/91691 91691-21681612@events.umich.edu Event Begins: Monday, March 21, 2022 12:00am
Location: Off Campus Location
Organized By: Department of Chemistry

Inorganic
tba

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Other Mon, 21 Mar 2022 18:15:28 -0400 2022-03-21T00:00:00-04:00 2022-03-21T00:00:00-04:00 Off Campus Location Department of Chemistry Other
LHS Collaboratory (March 22, 2022 12:00pm) https://events.umich.edu/event/90095 90095-21667763@events.umich.edu Event Begins: Tuesday, March 22, 2022 12:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Presentation 1: PCORNet and the PaTH subnetwork

Kathleen McTigue, MD, MPH, MS

In this talk, Kathleen McTigue describes the vision of PCORNet, its organization, and its value to the field of clinical research. PCORNet is divided into regional subnetworks one of which is PaTH. The organization of PaTH along with its priories will be discussed.

Presentation 2: UM’s site within PCORNet/PaTH

David Williams, PhD

The University of Michigan is an institutional member of PaTH/PCORNet.
In this talk, David Williams describes the organization and processes of the UM site within PCORNet/PaTH, studies in which UM participates, and resources for UM investigators interested in participating in PCORNet studies.

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Lecture / Discussion Wed, 15 Dec 2021 22:38:45 -0500 2022-03-22T12:00:00-04:00 2022-03-22T13:30:00-04:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion Collaboratory logo
Operationalizing the exposome through chemical surveillance & bioeffect monitoring with high-resolution mass spectrometry (March 22, 2022 12:00pm) https://events.umich.edu/event/93450 93450-21704620@events.umich.edu Event Begins: Tuesday, March 22, 2022 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Registration required https://umich.zoom.us/webinar/register/WN_wum4p_pdRMKIixVZJAlicg

Douglas Walker is assistant professor in the Dept of Environmental Medicine & Public Health, Icahn School of Medicine, Mount Sinai. Dr. Walker's research is focused on using untargeted metabolomics to measure environmental exposures, and how exposures lead to biological changes that cause diseases. During his postdoctoral fellowship at Emory University, he acted as Director of Exposome Research for the Clinical Biomarkers Laboratory and was a member of the HERCULES Exposome Research Center. Through application of high-resolution mass spectrometry platforms, Dr. Walker has shown it is possible to provide measures of 10,000-100,000 chemical signals in a cost-effective manner using a single human blood sample, providing a key advance for nutritional assessment, precision medicine and exposome research. At Mount Sinai, his research will be focus on continued development and application of advanced analytical strategies for measuring the occurrence, distribution and magnitude of previously unidentified environmental exposures and assist in delineating the mechanisms underlying environment-related diseases in humans.

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Lecture / Discussion Tue, 15 Mar 2022 13:21:33 -0400 2022-03-22T12:00:00-04:00 2022-03-22T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Dr. Douglas Walker (Mt. Sinai) presents the M-LEEaD Environmental Research Seminar
6th Annual RNA Symposium (March 25, 2022 8:00am) https://events.umich.edu/event/93125 93125-21700908@events.umich.edu Event Begins: Friday, March 25, 2022 8:00am
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Symposium Agenda

8:30 / Morning Welcome: President Mary Sue Coleman
8:40 / Jack Szostak "The emergence of RNA from heterogeneous prebiotic chemistry"
9:35 / Gigi Storz "RNA-mediated regulation within protein-coding sequences"
10:30 / coffee break
10:55 / Chris Burge "Impact of RNA-Binding Proteins on Human Genomic Variation"
12:00 / Lunch - please register for free box lunch
1:00 / Afternoon Welcome: Rebecca Cunningham, Vice President for Research
1:10 / Wendy Gilbert “Decoding the untranslated”
2:05 / Michelle Hastings "Splice-Modulating Antisense Oligonucleotides for the Treatment of Disease"
2:55 / Panel discussion with keynote speakers
Topic: Future of RNA Therapeutics, moderated by John Androsavich, Pfizer Global Lead, RNA Medicine

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Lecture / Discussion Wed, 16 Mar 2022 15:43:32 -0400 2022-03-25T08:00:00-04:00 2022-03-25T16:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion 6th Annual RNA Symposium
3rd year Graduate Student Seminars (March 28, 2022 12:00am) https://events.umich.edu/event/91692 91692-21681613@events.umich.edu Event Begins: Monday, March 28, 2022 12:00am
Location: Off Campus Location
Organized By: Department of Chemistry

Inorganic
tba

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Other Mon, 28 Mar 2022 18:15:25 -0400 2022-03-28T00:00:00-04:00 2022-03-28T00:00:00-04:00 Off Campus Location Department of Chemistry Other
A New Way to Stop the Spread of Viral Respiratory Infections (March 29, 2022 4:00pm) https://events.umich.edu/event/93801 93801-21708246@events.umich.edu Event Begins: Tuesday, March 29, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

I want to speak about viral respiratory diseases, such as influenza and COVID-19. When COVID-19 first appeared, public health authorities worried about the new coronavirus being spread by contact with large fluid droplets or by residues upon droplet evaporation. The guidance for individual behavior that was given included washing hands, cleaning groceries, wearing face coverings, avoiding people who sneeze or cough, and keeping some social distance apart from other individuals. But a detailed understanding of flu transmission, which took decades to develop, led scientists to understand only relatively recently that SARS-CoV-2 follows the same path of airborne transmission. Researchers found that the virus is breathed out in small particles by infected individuals while talking, singing, sneezing, and coughing. And these viruses have been found in many indoor environments. Those infected can even spread the virus when showing no symptoms of being sick, which shows that transmission does not depend on coughing or sneezing. Large wet droplets are not required for transmission.

The transmission of many infectious diseases requires that pathogens can survive, that is, remain infectious, in the environment, outside the host. It has long been recognized that viral respiratory diseases show a seasonal variation in temperate parts of the world, such that they increase in the winter but decrease in the summer. This behavior is strongly correlated with outside temperature, but viruses are hardy and are not killed by temperature changes of the outdoors. Instead, evidence has accumulated that the correlation is strongest with relative humidity in which viruses show U-shaped viability, surviving best in high or low humidity but surviving much more poorly in the relative humidity range of 40 to 60 %.[1] People in temperate regions of the world spend about 90% of their time indoors, and the relative humidity of indoor air is typically much reduced in the wintertime caused by heating of the indoor air which is necessary to keep people warm.[2] Evidence will be presented that relative humidity affects the evaporation rate of aqueous microdroplets (aerosols) in the air, and that relative humidity values of 40-60% provide enough time to kill viruses in aqueous microdroplets.[3] This conclusion explains this seasonal variation, which has heretofore been quite puzzling and often ignored. We find that this killing is promoted by the presence of reactive oxygen species (ROS) in aqueous microdroplets in the size range of 1 to 20 microns in diameter. The possible mechanism for the formation of ROS will be discussed.

References:

1. Lin K, Marr LC. (2020) "Humidity-dependent decay of viruses, but not bacteria, in aerosols and droplets follows disinfection kinetics," Environmental Science & Technology 54, 1024-1032.
2. Bozic A, Kanduc M. (2021) "Relative humidity in droplet and airborne transmission of disease." Journal of Biological Physics 47,1-29.
3. Dulay MT, Huerta Aguila AC, Chamberlayne CF, Zare RN, Davidse A, Vukovic S. (2021), "Effect of Relative Humidity on Hydrogen Peroxide Production in Water Droplets," QRB Discovery 2, e8, 1-6.





Dick Zare (Stanford University)

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Other Tue, 29 Mar 2022 18:15:35 -0400 2022-03-29T16:00:00-04:00 2022-03-29T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
DCMB / CCMB Weekly Seminar presents Rehan Akbani, PhD (Associate Professor, University of Texas, MD Anderson Cancer Center) (March 30, 2022 4:00pm) https://events.umich.edu/event/93933 93933-21711327@events.umich.edu Event Begins: Wednesday, March 30, 2022 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

The TP53 tumor suppressor gene is frequently mutated in human cancers. We illustrate the “omics” landscape of the TP53 pathway across five data platforms in 10,225 patient samples from 33 cancers reported by The Cancer Genome Atlas (TCGA). More than 91% of TP53-mutant cancers exhibit second allele loss by mutation, chromosomal deletion, or copy-neutral loss of heterozygosity. TP53 mutations are associated with enhanced chromosomal instability, including increased amplification of oncogenes and deep deletion of tumor suppressor genes. Tumors with TP53 mutations differ from their non-mutated counterparts in RNA, miRNA, and protein expression patterns, with mutant TP53 tumors displaying enhanced expression of cell cycle progression genes and proteins. A mutant TP53 RNA expression signature shows significant correlation with reduced survival in 11 cancer types. Pathway activity scores were computed for all the samples using mRNA expression levels of ten TP53 pathway member genes. Gynecologic cancers show high activity of the pathway. The pathway is correlated with immune infiltration and EMT, and anti-correlated with RTK and RAS/MAPK pathways. In particular, a strong correlation with immune infiltration is observed in breast cancer. ATAC-seq data also show high chromatin accessibility of the pathway genes in breast cancer. Thus, the TP53 pathway has profound effects on tumor cell genomic structure, expression, and clinical outlook depending on tumor type.

Short Bio
Dr. Rehan Akbani is an Associate Professor at the University of Texas MD Anderson Cancer Center in Houston, Texas, in the Department of Bioinformatics and Computational Biology. He has worked at MD Anderson since 2009. He has played many leadership roles in major enterprises, including as PI on TCGA’s MD Anderson Genome Data Analysis Center (GDAC) grant. Within the TCGA consortium, he led four of TCGA’s analysis working groups and he’s been a co-author on each one of TCGA’s 33 marker papers and 27 pan-cancer papers since 2009. His primary contributions have been leading the analysis of proteomics data, and batch effects and quality control of omics data. He won the AACR “Team Science Award” in 2020 for his work in TCGA. He was conferred the “Highly Cited Researchers 2019” award by Web of Science for co-authoring the most highly cited papers in the past decade. He has over 87,700 citations and an h-index of 78 on Google Scholar. In 2014, he won the “Test of Time” award from the European Conference on Machine Learning (ECML) for publishing the most highly cited paper in ECML a decade ago. Currently, Dr. Akbani is the Co-Director of MD Anderson’s proteomics core and Co-Director of the metabolomics core, where he’s led the development of software pipelines for normalizing raw data and generating customer reports semi-automatically. He’s also contributed proteomics data analysis for projects including the Cancer Cell Line Encyclopedia (CCLE) and the MD Anderson Cell Line Project (MCLP).

Host: Veera Baladandayuthapani, Ph.D.
https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Lecture / Discussion Thu, 24 Mar 2022 12:32:18 -0400 2022-03-30T16:00:00-04:00 2022-03-30T17:00:00-04:00 Off Campus Location DCMB Seminar Series Lecture / Discussion Rehan Akbani, PhD (Associate Professor, University of TX MD Anderson Cancer Center)
“Bioengineered Synthetic Hydrogels for Regenerative Medicine" (March 31, 2022 12:00pm) https://events.umich.edu/event/92752 92752-21695194@events.umich.edu Event Begins: Thursday, March 31, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

Andrés J. García is the Executive Director of the Petit Institute for Bioengineering and Bioscience and Regents’ Professor at the Georgia Institute of Technology. Dr. García’s research program integrates innovative engineering, materials science, and cell biology concepts and technologies to create cell-instructive biomaterials for regenerative medicine and generate new knowledge in mechanobiology. This cross-disciplinary effort has resulted in new biomaterial platforms that elicit targeted cellular responses and tissue repair in various biomedical applications, innovative technologies to study and exploit cell adhesive interactions, and new mechanistic insights into the interplay of mechanics and cell biology.

In addition, his research has generated intellectual property and licensing agreements with start-up and multi-national companies. He is a co-founder of 3 start-up companies (CellectCell, CorAmi Therapeutics, iTolerance). He has received several distinctions, including the NSF CAREER Award, Young Investigator Award from the Society for Biomaterials, Georgia Tech’s Outstanding Interdisciplinary Activities Award, the Clemson Award for Basic Science from the Society for Biomaterials, the International Award from the European Society for Biomaterials, and Georgia Tech’s Class of 1934 Distinguished Professor Award.

He is an elected Fellow of Biomaterials Science and Engineering (by the International Union of Societies of Biomaterials Science and Engineering), Fellow of the American Association for the Advancement of Science, Fellow of the American Society of Mechanical Engineers, and Fellow of the American Institute for Medical and Biological Engineering. He served as President for the Society for Biomaterials in 2018-2019. He is an elected member of the National Academy of Engineering, the National Academy of Medicine, and the National Academy of Inventors.

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Lecture / Discussion Fri, 18 Mar 2022 10:06:32 -0400 2022-03-31T12:00:00-04:00 2022-03-31T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Lecture / Discussion Andrés J. García, Ph.D.
Physics-Inspired Machine Learning Methods: A Status Report on Predictive Chemistry (March 31, 2022 4:00pm) https://events.umich.edu/event/91346 91346-21678335@events.umich.edu Event Begins: Thursday, March 31, 2022 4:00pm
Location: Off Campus Location
Organized By: Department of Chemistry

Physical
Teresa Head-Gordon (University of California - Berkeley)

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Other Thu, 31 Mar 2022 18:15:33 -0400 2022-03-31T16:00:00-04:00 2022-03-31T17:30:00-04:00 Off Campus Location Department of Chemistry Other
Proteostasis and Viral Evolution (April 4, 2022 4:00pm) https://events.umich.edu/event/85240 85240-21626064@events.umich.edu Event Begins: Monday, April 4, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our group is broadly interested in understanding how cells fold complex proteins, as well as in the design and application of next-generation in vivo directed evolution platforms. In recent work, we used chemical genetic tools for controlling mammalian proteostasis networks to reveal that RNA viruses hijack host chaperones to facilitate their rapid evolution. This phenomenon has proven broadly significant for understanding viral adaptation and pathology. More recently, we discovered that host protein quality control mechanisms (as opposed to folding chaperones) can have the opposite effect on viral evolution -- effectively constraining viral mutational space. The connections drawn between host proteostasis and viral evolution have potentially significant implications for topics including viral host-switching, vaccine development, and the design of improved antiviral therapeutic strategies. Moreover, these principles may provide strategies to turbo-charge directed evolution campaigns aimed at the development of new biotechnologies.

Matthew Shoulders (Massachusetts Institute of Technology)

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Other Mon, 04 Apr 2022 18:15:27 -0400 2022-04-04T16:00:00-04:00 2022-04-04T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Environmental Injustice in the Southend of Dearborn (April 5, 2022 12:00pm) https://events.umich.edu/event/93452 93452-21704623@events.umich.edu Event Begins: Tuesday, April 5, 2022 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Registration required https://umich.zoom.us/webinar/register/WN_YhR24FAcQUm3sDY3FZmfwg

The next in the R&R series of talks featuring residents and researchers discussing the environment, health and community is "Environmental Injustice in the Southend of Dearborn".

Panelists include Samra'a Luqman, and environmental activist in the Southend of Dearborn and Zeina Reda, a University of Michigan student. Moderated by Natalie Sampson, Associate Professor of Health and Human Services, University of Michigan-Dearborn.

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Lecture / Discussion Tue, 15 Mar 2022 13:53:19 -0400 2022-04-05T12:00:00-04:00 2022-04-05T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion R&R: Residents and Researchers Tuesday Talks at 12 on environment, health, and community
Mini-Enzymes for Hydrogen Production and Small Molecule Activation (April 5, 2022 4:00pm) https://events.umich.edu/event/84372 84372-21623618@events.umich.edu Event Begins: Tuesday, April 5, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Inorganic
Kara Bren (University of Rochester)

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Other Tue, 05 Apr 2022 18:15:24 -0400 2022-04-05T16:00:00-04:00 2022-04-05T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Chaperoning Protein Folding with RNA, and Fun with Foldit (April 8, 2022 12:00pm) https://events.umich.edu/event/94317 94317-21733895@events.umich.edu Event Begins: Friday, April 8, 2022 12:00pm
Location: Chemistry Dow Lab
Organized By: LSA Biophysics

Maintaining the folding health of the proteome is a critical cellular task. It has recently become appreciated that RNAs and RNA:protein complexes play important roles in maintenance of proteomic health. Here, we investigate the role of RNAs in direct modulation of protein aggregation and folding. To begin, an in vitro screen identified that G-quadruplexes are highly efficient general molecular chaperones. Testing these G-quadruplexes in E. coli demonstrated that these RNAs improve the protein folding environment in the cell. Protein folding experiments showed that some G-quadruplexes directly accelerate protein folding. In-cell experiments then found that this acceleration of protein folding drives better quality protein folding in E. coli. Finally, fast protein:RNA oligomerization was discovered for several G-quadruplexes, providing a biophysical explanation for the outsized role of G-quadruplexes in protein aggregation diseases such as Alzheimer’s Disease and ALS. Together, these studies provide a striking example of how RNA structure impacts protein folding and misfolding disease. We will additionally discuss the use of citizen science both to improve structural biology research and biochemistry education using the biochemistry video game Foldit.

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Workshop / Seminar Mon, 04 Apr 2022 08:56:09 -0400 2022-04-08T12:00:00-04:00 2022-04-08T13:00:00-04:00 Chemistry Dow Lab LSA Biophysics Workshop / Seminar Chemistry Dow Lab
Metal Oxo Clusters in Oxidation Chemistry and Water-Splitting Catalysis (April 11, 2022 4:00pm) https://events.umich.edu/event/91343 91343-21678332@events.umich.edu Event Begins: Monday, April 11, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The conversion of solar energy into a useful chemical fuel represents a major scientific goal in the drive towards a society powered by renewable energy. Several potential solar fuels seem possible, including hydrogen from proton reduction, or hydrocarbons from the reduction of carbon dioxide. Useful rates of solar fuel production must rely on an efficient oxidation that generates electrons and protons. In nature's photosynthesis, this is accomplished by a tetra-manganese oxo cluster (the oxygen-evolving complex, OEC), which yields 4 protons and 4 electrons by the photo-oxidation of water (the oxygen evolution reaction, OER). For solar fuel applications this water-splitting half reaction must be catalyzed to make it energetically feasible, and transition-metal oxo cubane clusters related to the OEC represent intriguing model systems and design motifs for new water-splitting catalysts based on abundant metals. Molecularly derived catalysts of this type offer potential advantages, including the synthetic tunability of catalytic and chemical properties. In addition, the study of high-valent molecular species can provide key insights into the mechanism of water oxidation and help bridge the gap between solid-state and molecular systems to allow for more rational design of catalysts. This presentation will describe high-valent metal complexes and clusters, and a detailed mechanism for the evolution of oxygen via water oxidation at a tetranuclear cobalt oxo cubane. An important aspect to this catalysis relates to the manner in which metals cooperate to mediate multi-electron, multi-proton oxidations. In further pursuit of these concepts, the synthesis and study of related heterometallic oxo clusters have been targeted.

Don Tilley (University of Caifornia, Berkeley)

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Other Mon, 11 Apr 2022 18:15:26 -0400 2022-04-11T16:00:00-04:00 2022-04-11T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Nickel-Mediated Radical Pathways and Applications to Peptide Modification (April 12, 2022 11:00am) https://events.umich.edu/event/94329 94329-21734377@events.umich.edu Event Begins: Tuesday, April 12, 2022 11:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Reactions involving organic radical intermediates have been traditionally regarded as overly reactive and unselective. Nickel complexes can mediate reactions involving radicals by forming metallo-radical intermediates, and thus modulate the reactivity and control the selectivity. We apply organometallic and physical organic techniques to characterize fundamental steps involved in nickel-catalyzed cross-coupling reactions, including radical generation, chain propagation, termination, and C–C bond formation. Mechanistic insight has informed us in the development of an enantioselective method to modify peptides. The reaction provides a convenient means to access non-canonical peptides that could serve as pharmaceutical targets.
Tianning Diao (New York University)

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Other Tue, 12 Apr 2022 18:15:17 -0400 2022-04-12T11:00:00-04:00 2022-04-12T12:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Capture and Release of Metals of Energy Importance Using Redox-Switchable Carboranes (April 12, 2022 4:00pm) https://events.umich.edu/event/90378 90378-21670539@events.umich.edu Event Begins: Tuesday, April 12, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Inorganic
Gabriel Menard (UC Santa Barbara)

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Other Tue, 12 Apr 2022 18:15:17 -0400 2022-04-12T16:00:00-04:00 2022-04-12T17:15:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
UM/Agilent Measurement Symposium (April 13, 2022 5:00pm) https://events.umich.edu/event/85162 85162-21625673@events.umich.edu Event Begins: Wednesday, April 13, 2022 5:00pm
Location: Off Campus Location
Organized By: Department of Chemistry

Analytical

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Other Mon, 21 Mar 2022 12:15:27 -0400 2022-04-13T17:00:00-04:00 2022-04-13T20:45:00-04:00 Off Campus Location Department of Chemistry Other
UM Agilent Measurement Symposium (April 14, 2022 9:00am) https://events.umich.edu/event/85072 85072-21625546@events.umich.edu Event Begins: Thursday, April 14, 2022 9:00am
Location: Weiser Hall
Organized By: Department of Chemistry

Analytical
David Russell(TAMU) , Susan Olesik(Ohio State University) , John Fjeldsted(Agilent) , Darlene Solomon(Agilent)

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Other Thu, 14 Apr 2022 18:15:24 -0400 2022-04-14T09:00:00-04:00 2022-04-14T17:00:00-04:00 Weiser Hall Department of Chemistry Other Weiser Hall
Cellular Mechanisms of Lip and Primary Palate Fusion (April 14, 2022 12:00pm) https://events.umich.edu/event/94366 94366-21735840@events.umich.edu Event Begins: Thursday, April 14, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

A. Personal Statement

Highlighted publications:

Lewis A.E., Kuwahara A., Franzosi J., Bush, J.O.* (2022) Tracheal separation is driven by NKX2-1-mediated repression of Efnb2 and regulation of endodermal cell sorting. Cell Reports, 38(11):110510

Kindberg A.A., Srivastava, V., Muncie, J.M., Weaver V.M., Gartner, Z.J. and Bush, J.O.* (2021). EPH/EPHRIN regulates cellular organization by actomyosin contractility effects on cell contacts Journal of Cell Biology 220 (6): e202005216 PMCID: PMC8025214

Kuwahara, A., Lewis, A., Coombes, C., Leung, F.S., Percharde M., Bush J.O.* (2020) Delineating the early transcriptional specification of the mammalian trachea and esophagus. eLife, 9:e55526 PMCID: PMC7282815

Niethamer, T. K., Teng, T., Franco, M., Du, Y. X., Percival, C. J., Bush, J.O.* (2020). Aberrant cell segregation in the craniofacial primordium and the emergence of facial dysmorphology in craniofrontonasal syndrome. PLoS Genet. 16, e1008300.

Highlighted projects:
R35 DE031926-01 (PI: Bush) 4/1/2022-3/31/2030
NIH/NIDCR
Signaling control and cellular basis of craniofacial morphogenesis and congenital disease

R01 DE023337 (PI: Bush) 7/9/2013-3/31/2022
NIH/NIDCR
Mechanisms of Eph/Ephrin signaling in craniofacial morphogenesis and craniofrontonasal syndrome

R01DE028753 (PI: Selleri) 4/1/2019-3/31/2024
NIH/NIDCR
Phenotype-driven approach to understanding the function of craniofacial regulators using IMPC-generated mouse strains

UG3DE028872 (PI: Klein) 7/1/2019-6/30/2024
NIH/NIDCR
“Enamel atlas: systems-level amelogenesis tools at multiple scales”

B. Positions, Scientific Appointments and Honors
Positions and Employment:
2019-present Vice Chair, Department of Cell and Tissue Biology
2021-present Professor, Department of Cell and Tissue Biology and Program in Craniofacial Biology, University of California at San Francisco
2017-2021 Associate Professor, Department of Cell and Tissue Biology and Program in Craniofacial
Biology, University of California at San Francisco
2011-2017 Assistant Professor, Department of Cell and Tissue Biology and Program in
Craniofacial Biology, University of California at San Francisco
2005-2011 Postdoctoral research at FHCRC/MSSM
Advisor: Dr. Philippe Soriano
1999-2005 Graduate and postdoctoral research at University of Rochester
Advisor: Dr. Rulang Jiang

Awards and Honors:
2021 Marylou Buyse Distinguished Scientist in Craniofacial Research award from the Society for Craniofacial Genetics and Developmental Biology
2019 F1000 Faculty member for Developmental Biology
2019 David W. Smith workshop on malformations and morphogenesis keynote
2014 American Association of Anatomists Young Faculty Travel Award
2010-present F1000/F1000Prime has featured and highly ranked five of our publications
2010 NIH pathway to independence award from NIH/NIDCR K99/R00 (DE020855)
2006-2008 Ruth L Kirschstein NRSA Individual Fellowship from NIH/NIDCR F32 (DE17506)
2005 Basil Bibby award from the AADR
2004 Michael G. Buonocore award from the AADR

Other Experience and Professional Memberships
2021-2025 Member NIH Skeletal Biology Development and Disease (SBDD)
2021 Cold Spring Harbor Labs Mouse Engineering Course lecturer and workshop leader
2021 American Association of Anatomists Program Committee
2020 Ad hoc reviewer NIH/NIDCR SEP ZDE1 Endogenous Regeneration of Dental, Oral and Craniofacial Tissue
2020 Ad hoc reviewer NIH CSR ZRG1 Fellowships: Cell Biology, Developmental Biology and Bioengineering
2020 Ad hoc reviewer Czech Science Foundation
2019 Ad hoc reviewer for NIH Skeletal Biology Development and Disease (SBDD)
2017 Ad hoc reviewer for NIH on Microphysiological Systems (MPS) for Disease Modeling and Efficacy Testing (UG3/UH3) “Tissue Chips and Disease Modeling”
2017-present International Association for Dental Research
2017 Guest Editor, Developmental Biology, special issue on signaling in development
2014 Ad hoc reviewer for NIH on SEP ZRG1 MOSS-D (02), “Bone, Cartilage and Tendon”
2013, 2014 Invited peer reviewer for UK MRC
2012 Ad hoc reviewer for NIH on Council ZES1, “Environmental influences on stem cells in development, health and disease”
2012 Organizer, session chair, Society of Craniofacial Genetics Annual Meeting, San Francisco, CA
2012-present Member, Society for Craniofacial Genetics and Development
2010-present Member, American Association of Anatomists
2000-present Member, Society for Developmental Biology
Ad hoc Reviewer for Development, Developmental Biology, Developmental Dynamics, Journal of Dental Research, Genesis, Immunobiology, Journal of Cell Biology, Science, PLOS Genetics, Immunobiology, PLOS One, Developmental Cell, PLOS Biology, Human Molecular Genetics, JOVE

C. Contributions to Science
1. Identified Eph/ephrin cellular mechanisms in morphogenesis
We have made major contributions to understanding EPH/EPHRIN signaling mechanisms in development in multiple contexts including the craniofacial, neural and neural crest systems. The EPHs compose the largest family of receptor tyrosine kinases in the vertebrate genome constituting one quarter of the total number. Though extensively studied in the nervous system, the signaling mechanisms utilized by this family in other contexts are complex and modestly understood, particularly in vivo. We have learned that a large number of these molecules exhibit distinct expression patterns in the developing craniofacial region. In a novel “conditional-rescue” approach we discovered that EPHRIN-B2 is required in the vascular endothelium for normal NCC development. EPH/EPHRIN signaling is widely known to regulate cellular organization, but the signaling mechanisms by which it does so are unclear. By studying a series of targeted and signaling mutations in EPHRIN-B1 and its receptors EPHB2 and EPHB3 in mice, we determined that EPH/EPHRIN cell segregation involves unidirectional forward signaling from EPHRIN-B1 and relies on kinase activity of the receptors. By live cell imaging we also observe that this unidirectional signaling results in changes in cortical actomyosin accumulation and leading us to interrogate the biophysical basis for EPH/EPHRIN cell segregation. We recently discovered that EPH/EPHRIN signaling modulates the strength of cell-cell contacts by regulating cell interfacial tension through increased heterotypic cortical actomyosin contractility. The minimization of heterotypic interfacial tension also informs how EPH/EPHRIN signaling regulates tissue shape changes relevant to Contributions number 2 and 4. Current efforts in this area focus on how EPH/EPHRIN signaling regulates mesenchymal cell polarity and cell position, forming the basis for part of “Focus one” of this proposal.

Agrawal, P., Wang, M., Kim, S., Lewis, A.E., Bush, J.O.* (2014) The embryonic expression of EphA receptor genes in mice supports their candidacy for involvement in cleft lip and palate. Developmental Dynamics, 243 (11): 1470-6. PMCID: PMC4404412
Lewis, A.E., Hwa, J., Wang, R., Soriano P., Bush, J.O.* (2015) Neural crest defects in ephrin-B2 mutant mice are non-autonomous and originate from defects in the vasculature. Developmental Biology, 406(2): 186-95. PMCID: PMC4639416
O’Neill, A.O., Kindberg, A.A., Niethamer, T.K. Larson, A.R., Ho, H.H., Greenberg, M.E., Bush, J.O.* (2016) Unidirectional Eph/ephrin signaling creates a cortical actomyosin differential to drive cell segregation. Journal of Cell Biology, 215 (2): 217 PMCID: PMC5984648
Kindberg A.A., Srivastava, V., Muncie, J.M., Weaver V.M., Gartner, Z.J. and Bush, J.O.* (2021). EPH/EPHRIN regulates cellular organization by actomyosin contractility effects on cell contacts Journal of Cell Biology 220 (6): e202005216 PMCID: PMC8025214

2. Delineated Eph/ephrin signaling mechanisms underlying craniofrontonasal syndrome
We have focused on the role of EPH/EPHRIN signaling in craniofrontonasal syndrome (CFNS), an X-linked condition caused by mutations in EFNB1 characterized by hypertelorism, craniosynostosis, cleft lip and palate, agenesis of the corpus callosum, and particularly increased severity in female patients. By generating a series of signaling mutations in three different gene targeted mouse lines, we were able to determine the relevant modes of signaling for different EPHRIN-B1 phenotypes. We found that reverse signaling by a PDZ-dependent mechanism is critical for axon guidance, whereas it is dispensible for skeletal and craniofacial development. This work showed that different aspects of craniofrontonasal syndrome are caused by loss of function of distinct molecular EPHRIN-B1 signaling functions. Further, by integrating mouse genetics, phosphoproteomic and transcriptomic approaches we have investigated downstream signaling pathways utilized by EPHRIN-B1 in craniofacial development and disease. In this context, we were the first to show that EPH receptor expression is regulated by endocytosis in vivo, and that EPHRIN-B1 controls cell proliferation by the Ras/MAPK signaling pathway. We have also generated an hiPSC model for CFNS, which to our knowledge is the first hiPSC model of a congenital craniofacial syndrome, and used to it ask key questions about the cellular etiology underlying this perplexing disease. Recently, we coupled geometric morphometric techniques with temporal and spatial manipulation of EPHRIN-B1 signaling to elucidate how Efnb1 mutations result in stereotyped dysmorphology in CFNS. Current efforts in this area focus on delineating the proximal signal transduction mechanisms employed by EPH/EPHRIN-B1 signaling in craniofacial morphogenesis using CRISPR/CAS9 based methods.

Bush, J. O. and Soriano, P. (2010). Ephrin-B1 forward signaling regulates craniofacial morphogenesis by controlling cell proliferation across Eph-ephrin boundaries. Genes Dev. 24, 2048-60. PMCID: PMC2939368
Niethamer, T.K., Larson, A.R., O’Neill A.K., Bershteyn, M., Hsiao, E.C., Klein, O.D., Pomerantz, J.H., Bush J.O.* (2017) EPHRIN-B1 mosaicism drives cell segregation in craniofrontonasal syndrome hiPSC-derived neuroepithelial cells. Stem Cell Reports, 8(3): 529-537. PMCID: PMC5355632
Niethamer, T. K. and Bush, J. O.* (2019). Getting direction(s): The Eph/ephrin signaling system in cell positioning. Dev. Biol. 447, 42–57.
Niethamer, T. K., Teng, T., Franco, M., Du, Y. X., Percival, C. J., Bush, J. O. (2020). Aberrant cell segregation in the craniofacial primordium and the emergence of facial dysmorphology in craniofrontonasal syndrome. PLoS Genet. 16, e1008300.

3. Developed live imaging approaches to discover cellular mechanisms of craniofacial tissue fusions
Though tissue fusion is a critical final step of lip and palate development, we currently lack cellular resolution understanding of how these tissue fusion events occur, and how they are controlled. We have been examining the cellular and molecular mechanisms by which tissue fusion occurs by combining live imaging of mouse morphogenesis with mouse genetic and physical perturbations. We developed the first successful application of confocal live imaging technology to secondary palate development, and it has allowed us to make new discoveries on the cellular mechanisms at play. Our results indicate that tissue fusion proceeds by a progression of dynamic cell behaviors beginning with convergence of two independent epithelia and concomitant to orthogonal displacement of the resultant shared epithelium. Further, we have found that epithelial cell extrusion, in which cells are squeezed out of an epithelium, is a novel contributor to the removal of the midline epithelial seam (MES). A nearly completed manuscript presents a new live imaging approach to understanding secondary palate fusion, and demonstrates a unique and novel form of collective epithelial migration that is crucial for this process. Most recently, we have also established live imaging approaches for the study of upper lip/primary palate fusion, which we are using to study roles for actomyosin contractility and cell adhesion in this process.

Bush J.O.*, Jiang R.* (2012) Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development. Development. 139(2):231-43. PMCID: PMC3243091
Kim, S., Lewis A.E., Singh V., Ma, X., Adelstein, R., Bush, J.O.,* (2015) Convergence and extrusion are required for normal fusion of the mammalian secondary palate. PLOS Biology, 13(4) PMCID: 4388528
Kim S., Prochazka, J., Bush J.O.*, (2017) Live imaging of Mouse Secondary Palate Fusion. JoVE. July 2017 (125) PMCID: In process

4. Improved mouse genetics tools for the study of craniofacial and neural crest development and disease
In the course of our studies, we discovered that the Wnt1-Cre mouse line exhibits developmental phenotypes attributable to elevated and ectopic activation of Wnt signaling. This is a standard and widely used reagent in the fields of craniofacial development and neural crest stem cell biology and our careful analysis of this reagent has already had broad-reaching effects causing labs to re-examine previously published work. To provide a reagent that is devoid of these complications, we generated a Wnt1-Cre2 transgenic mouse line that exhibits the same pattern of activity as Wnt1-Cre but does not cause ectopic activation of Wnt signaling or developmental phenotypes. Over the past five years, I have also served as the faculty advisor for the UCSF mouse inventory database, which facilitates the sharing of genetically modified mouse lines. Most recently, my lab has successfully adopted the iGONAD electroporation method for rapid generation of new mouse lines which we are employing to generate new mouse models for the study of congenital disease.

Lewis, A., Vasudevan, H., O’Neill, A., Soriano, P., Bush, J.O.* (2013) The widely used Wnt1-Cre transgene causes developmental phenotypes by ectopic activation of Wnt signaling. Developmental Biology, 379(2):229-34. PMCID: PMC3804302
Wall, E., Scoles, J., Joo, A., Klein, O., Quinonez, C., Bush, J. O., Martin, G. R. and Laird, D. J. (2020). The UCSF Mouse Inventory Database Application, an Open-Source Web App for Sharing Mutant Mice within a Research Community. G3 (Bethesda).

5. Understanding how cell fate and morphogenesis are coupled in the developing foregut
Based initially on phenotypes that we discovered in an Efnb2 mutant mouse line that we generated, we have now established a robust research focus on understanding the specification and morphogenesis of the trachea and esophagus. Classical developmental biology experiments hypothesize that two transcription factors, NKX2.1 and SOX2 act as master regulators of these fates, but this remains untested at the transcriptome level and their targets were unknown. we combine state-of-the-art transcriptomic experiments in embryonic tissues with functional mouse genetic experiments to expose the fundamental process of fate specification of the trachea and esophagus. We performed single cell RNA sequencing in mice to establish a transcriptome-wide understanding of the early steps of trachea and esophagus development and used these data, combined with RNA-sequencing of mutants and embryonic ChIP-seq to interrogate the transcriptome-wide function of NKX2.1 in tracheal and esophageal development. The results of these experiments provide a new understanding of how the trachea and esophagus are initially specified at the genome-wide level. Our studies also reveal that NKX2.1 directly represses Efnb2 to regulate the site of tracheoesophageal separation. These discoveries may be impactful to the study of tracheal, lung, and esophageal developmental biology and related structural anomalies in humans, as well as for the fields of embryonic stem cell biology and for lung and esophageal cancer for which these are keystone transcriptional pathways.

Kuwahara, A., Lewis, A., Coombes, C., Leung, F.S., Percharde M., Bush J.O.* (2020) Delineating the early transcriptional specification of the mammalian trachea and esophagus. eLife, 9:e55526 PMCID: PMC7282815
Lewis A.E., Kuwahara A., Franzosi J., Bush, J.O.* (2022) Tracheal separation is driven by NKX2-1-mediated repression of Efnb2 and regulation of endodermal cell sorting. Cell Reports, 38(11):110510

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Lecture / Discussion Tue, 05 Apr 2022 10:39:07 -0400 2022-04-14T12:00:00-04:00 2022-04-14T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Lecture / Discussion Jeffrey Bush Professor and Vice Chair, Department of Cell and Tissue Biology and Program in Craniofacial Biology
Shaomeng Wang Drug Discovery Award Lecture (April 14, 2022 4:00pm) https://events.umich.edu/event/94455 94455-21739821@events.umich.edu Event Begins: Thursday, April 14, 2022 4:00pm
Location: Palmer Commons
Organized By: U-M College of Pharmacy

The Univeristy of Michigan College of Pharmacy is pleased to announce the first Shaomeng Wang Drug Discovery Award Lecture: “Chemical Strategies for Drugging the Undruggable, from KRAS to p53,” presented by Kevan M. Shokat, PhD, Professor, Department of Cellular and Molecular Pharmacology, UCSF; Professor, Department of Chemistry, UC Berkeley; Investigator, Howard Hughes Medical Institute.

Kevan M. Shokat received his B.A. in Chemistry from Reed College in 1986, his Ph.D. in organic chemistry at UC Berkeley with Professor Peter Schultz and carried out post-doctoral work in cellular immunology at Stanford University with Professor Chris Goodnow. Kevan’s research group is focused on the discovery of new small molecule tools and drug candidates targeting protein/lipid kinases, GTPases, and RNA helicases. His laboratory utilizes the tools of synthetic organic chemistry, protein engineering, structural biology, biochemistry and cell biology. He was inducted into the National Academy of Sciences (2010), the National Academy of Medicine (2011), and the American Academy of Arts and Sciences (2011). He has commercialized discoveries from his laboratory through co-founding several biotechnology companies including Intellikine, Araxes, Wellspring Biosciences, Kura Oncology, eFFECTOR Therapeutics, Mitokinin, Revolution Medicines, Erasca and Kumquat Biosciences.

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Lecture / Discussion Thu, 07 Apr 2022 09:02:06 -0400 2022-04-14T16:00:00-04:00 2022-04-14T17:00:00-04:00 Palmer Commons U-M College of Pharmacy Lecture / Discussion Shaomeng Wang Drug Discovery Award Lecture
Viral Noncoding RNAs: New Insights into RNA Structure (April 18, 2022 4:00pm) https://events.umich.edu/event/86654 86654-21635378@events.umich.edu Event Begins: Monday, April 18, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Chembio
Joan Steitz (Yale University School of Medicine)

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Other Mon, 18 Apr 2022 18:15:10 -0400 2022-04-18T16:00:00-04:00 2022-04-18T17:15:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Pamela V. Chang (April 26, 2022 4:00pm) https://events.umich.edu/event/85229 85229-21626007@events.umich.edu Event Begins: Tuesday, April 26, 2022 4:00pm
Location: Off Campus Location
Organized By: Department of Chemistry

Chembio
Pamela Chang (Cornell University)

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Other Tue, 26 Apr 2022 18:15:08 -0400 2022-04-26T16:00:00-04:00 2022-04-26T17:30:00-04:00 Off Campus Location Department of Chemistry Other
Controlling Localized Surface Plasmons via an Atomistic Approach: Chemical Analysis at Angstrom Scale and Site-Selective Reactions at Sub-Molecular Scale (April 27, 2022 4:00pm) https://events.umich.edu/event/84370 84370-21623616@events.umich.edu Event Begins: Wednesday, April 27, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

My research group is interested in investigating how local chemical environments affect single-molecule behaviors with angstrom scale resolution. This talk will start from Tip-Enhanced Raman Spectroscopy (TERS), which affords the spatial resolution of traditional Scanning Tunneling Microscopy (STM) while collecting the chemical information provided by Raman spectroscopy. By using a plasmonically-active material for our scanning probe, the Raman signal at the tip-sample junction is incredibly enhanced, allowing for single-molecule probing. This method, further aided by the benefits of ultrahigh vacuum, is uniquely capable of controlling localized plasmons via an atomistic approach. We are able to obtain (1) single-molecule chemical identification; (2) the configurations and orientations of individual molecules on the surface; (3) adsorbate-substrate interactions in the ordering of molecular building blocks in supramolecular nanostructures; (4) local strain effects in an organic/2D materials heterostructure. By investigating substrate structures, superstructures, 2D materials lattices, and the adsorption orientations obtained from vibrational modes, we extract novel surface-chemistry information at an unprecedented spatial (< 1 nm) and energy (< 10 wavenumber) resolution. Another application of localized surface plasmons is to achieve site-selective chemical reactions at sub-molecular scale. We recently selectively and precisely activated multiple chemically equivalent reactive sites one by one within the structure of a single molecule by scanning probe microscopy tip-controlled plasmonic resonance. Our method can interrogate the mechanisms of forming and breaking chemical bonds at the angstrom scale in various chemical environments, which is critical in designing new atom- and energy-efficient materials and molecular assemblies with tailored chemical properties.



Nan Jiang (University of Illinois Chicago)

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Other Wed, 27 Apr 2022 18:15:12 -0400 2022-04-27T16:00:00-04:00 2022-04-27T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Mohammad R. Seyedsayamdost (May 3, 2022 4:00pm) https://events.umich.edu/event/88355 88355-21653505@events.umich.edu Event Begins: Tuesday, May 3, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Chembio
Mohammad Seyedsayamdost (Princeton)

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Other Wed, 06 Apr 2022 06:15:29 -0400 2022-05-03T16:00:00-04:00 2022-05-03T17:15:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
TBA (May 3, 2022 4:00pm) https://events.umich.edu/event/91342 91342-21678331@events.umich.edu Event Begins: Tuesday, May 3, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Materials
Mohammad Seyedsayamdost

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Other Wed, 06 Apr 2022 06:15:29 -0400 2022-05-03T16:00:00-04:00 2022-05-03T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Interdisciplinary QC/CM Seminar | Manifestation of Spin-Orbit and Electron-Nuclear Couplings in Computational Molecular Spectroscopy (May 5, 2022 4:00pm) https://events.umich.edu/event/91345 91345-21678334@events.umich.edu Event Begins: Thursday, May 5, 2022 4:00pm
Location: West Hall
Organized By: Department of Chemistry

The computational modeling of molecular spectroscopies requires an accurate treatment of spin-orbit and electron-nuclear couplings to fully understand the physical underpinnings of the spectroscopic signatures. In this talk, I will briefly review recent developments in relativistic electronic structure theory and electron-nuclear quantum dynamics from the Li research group, followed by computational studies of several advanced molecular spectroscopies and challenging chemical processes. L- and M-edge X-ray absorption, where large spin-orbit coupling splits the core p/d orbitals into several sublevels, can now be computed with relativistic electronic structure methods developed in the Li research group. These new methods can provide extremely important insights into chemical processes involving transition metal, rare earth, and heavy elements. In order to study the effect of quantum proton, we have developed the nuclear-electronic orbital Ehrenfest (NEO-Ehrenfest) dynamics, in collaboration with the Hammes-Schiffer group. NEO-Ehrenfest provides an elegant framework for treating electrons and selected nuclei, typically protons, quantum mechanically in nonequilibrium dynamical processes, such as the excited state intramolecular proton transfer process. Our simulations reveal that nuclear quantum effects influence the predictions of proton transfer reaction rates and kinetic isotope effects due to the intrinsic delocalized nature of the quantum nuclear wave function.
Xiaosong Li (University of Washington)

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Other Thu, 05 May 2022 18:15:06 -0400 2022-05-05T16:00:00-04:00 2022-05-05T17:30:00-04:00 West Hall Department of Chemistry Other West Hall
BMS-Michigan Symposium (May 27, 2022 12:00pm) https://events.umich.edu/event/95138 95138-21788507@events.umich.edu Event Begins: Friday, May 27, 2022 12:00pm
Location: Off Campus Location
Organized By: Department of Chemistry

Organic
Kami Hull(University of Texas) , Julia Kalow(Northwestern University) , Eric Simmons(Bristol Myers Squibb)

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Other Fri, 27 May 2022 18:15:07 -0400 2022-05-27T12:00:00-04:00 2022-05-27T17:00:00-04:00 Off Campus Location Department of Chemistry Other
7th Annual Gilbert S. Omenn, MD, PhD Lecture (June 3, 2022 10:00am) https://events.umich.edu/event/95013 95013-21788268@events.umich.edu Event Begins: Friday, June 3, 2022 10:00am
Location: Off Campus Location
Organized By: Omenn Lecture

Talk Title: Biomedical Data Science: The Hope, Hype, and Promise

Abstract: Data science was introduced as a “new” profession in the early 1960s, yet the Office of Data Science Strategy at the National Institutes of Health (NIH) was not established until 2018. Artificial intelligence (AI) traces its roots to at least the 1950s, with its first application as an expert system in medicine in the early 1970s. Yet, the NIH Working Group on AI was not established until 2018 as well, with their first report issued in 2019. This is not to say that these topics have been neglected over the past half-century, but it begs the question of why have they only now come to the forefront of biomedicine? We have seen multiple AI booms and busts, each of which has caused massive hype, dream crushing failures, and notable advancements (some more flashy than others) along the way. This talk is not intended to be a history lesson, but it will provide some context for how we got to where we are and what this says about where biomedical research and healthcare seems to be heading. I will further provide insight into how various innovations in computation, policy, and industry have pushed the field forward and where recently established programs to expand AI activities, such as AIM-AHEAD and Bridge2AI, may push the biomedical research community over the next decade. To ground this presentation, I will provide examples of how AI and data science more generally have driven activities at the All of Us Research Program and the Vanderbilt Health Data Science Center.

Short Bio: Bradley Malin is the Vice Chair for Research in the Department of Biomedical Informatics at Vanderbilt University Medical Center and is the Accenture Professor of Biomedical Informatics, Biostatistics, and Computer Science at Vanderbilt University. He founded and co-directs the Vanderbilt Health Data Science Center, as well as the Center for Genetic Privacy and Identity in Community Settings (GetPreCiSe), the latter of which is an NIH Center of Excellence in Ethical, Legal, and Social Implications Research. Since 2007, he has chaired the Committee on Access, Privacy, and Security (CAPS) for the NIH-sponsored All of Us Research Program and, in 2021, he became one of the founding PIs of the NIH Artificial Intelligence/Machine Learning Consortium to Advance Health Equity and Researcher Diversity (AIM-AHEAD). He serves on various governmental advisory bodies, including the Board of Scientific Counselors of the National Center for Health Statistics (NCHS) of the U.S. Centers for Disease Control and Medicine (CDC). He was honored as a Presidential Early Career Award for Scientists and Engineers (PECASE) and is an elected member of the National Academy of Medicine (NAM), the American College of Medical Informatics (ACMI), the American Institute for Medical and Biological Engineering (AIMBE), and the International Academy of Health Sciences Informatics (IAHSI) . He received a B.S. in Biological Sciences, M.S. in Machine Learning, M.Phil. in Public Policy and Management, and Ph.D. in Computer Science, all from Carnegie Mellon University.

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Lecture / Discussion Fri, 06 May 2022 12:03:12 -0400 2022-06-03T10:00:00-04:00 2022-06-03T11:00:00-04:00 Off Campus Location Omenn Lecture Lecture / Discussion Bradley Malin, PhD
7th Annual Gilbert S. Omenn, MD, PhD Lecture (June 3, 2022 10:00am) https://events.umich.edu/event/95013 95013-21789263@events.umich.edu Event Begins: Friday, June 3, 2022 10:00am
Location: Off Campus Location
Organized By: Omenn Lecture

Talk Title: Biomedical Data Science: The Hope, Hype, and Promise

Abstract: Data science was introduced as a “new” profession in the early 1960s, yet the Office of Data Science Strategy at the National Institutes of Health (NIH) was not established until 2018. Artificial intelligence (AI) traces its roots to at least the 1950s, with its first application as an expert system in medicine in the early 1970s. Yet, the NIH Working Group on AI was not established until 2018 as well, with their first report issued in 2019. This is not to say that these topics have been neglected over the past half-century, but it begs the question of why have they only now come to the forefront of biomedicine? We have seen multiple AI booms and busts, each of which has caused massive hype, dream crushing failures, and notable advancements (some more flashy than others) along the way. This talk is not intended to be a history lesson, but it will provide some context for how we got to where we are and what this says about where biomedical research and healthcare seems to be heading. I will further provide insight into how various innovations in computation, policy, and industry have pushed the field forward and where recently established programs to expand AI activities, such as AIM-AHEAD and Bridge2AI, may push the biomedical research community over the next decade. To ground this presentation, I will provide examples of how AI and data science more generally have driven activities at the All of Us Research Program and the Vanderbilt Health Data Science Center.

Short Bio: Bradley Malin is the Vice Chair for Research in the Department of Biomedical Informatics at Vanderbilt University Medical Center and is the Accenture Professor of Biomedical Informatics, Biostatistics, and Computer Science at Vanderbilt University. He founded and co-directs the Vanderbilt Health Data Science Center, as well as the Center for Genetic Privacy and Identity in Community Settings (GetPreCiSe), the latter of which is an NIH Center of Excellence in Ethical, Legal, and Social Implications Research. Since 2007, he has chaired the Committee on Access, Privacy, and Security (CAPS) for the NIH-sponsored All of Us Research Program and, in 2021, he became one of the founding PIs of the NIH Artificial Intelligence/Machine Learning Consortium to Advance Health Equity and Researcher Diversity (AIM-AHEAD). He serves on various governmental advisory bodies, including the Board of Scientific Counselors of the National Center for Health Statistics (NCHS) of the U.S. Centers for Disease Control and Medicine (CDC). He was honored as a Presidential Early Career Award for Scientists and Engineers (PECASE) and is an elected member of the National Academy of Medicine (NAM), the American College of Medical Informatics (ACMI), the American Institute for Medical and Biological Engineering (AIMBE), and the International Academy of Health Sciences Informatics (IAHSI) . He received a B.S. in Biological Sciences, M.S. in Machine Learning, M.Phil. in Public Policy and Management, and Ph.D. in Computer Science, all from Carnegie Mellon University.

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Lecture / Discussion Fri, 06 May 2022 12:03:12 -0400 2022-06-03T10:00:00-04:00 2022-06-03T11:00:00-04:00 Off Campus Location Omenn Lecture Lecture / Discussion Bradley Malin, PhD
Juneteenth Seminar (June 20, 2022 12:00pm) https://events.umich.edu/event/95563 95563-21790156@events.umich.edu Event Begins: Monday, June 20, 2022 12:00pm
Location: Off Campus Location
Organized By: Department of Chemistry

Analytical
Renã Robinson (Vanderbilt University)

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Other Mon, 20 Jun 2022 18:15:09 -0400 2022-06-20T12:00:00-04:00 2022-06-20T13:15:00-04:00 Off Campus Location Department of Chemistry Other
LHS Collaboratory (June 21, 2022 12:00pm) https://events.umich.edu/event/95245 95245-21789057@events.umich.edu Event Begins: Tuesday, June 21, 2022 12:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

"Restructuring health systems for learning: Building equity into the Learning Health System"
Learn more about ELSI-LHS (Ethical, Legal, and Social Implications of Learning Health Systems). The session will be moderated by, Jody E. Platt, MPH, PhD, Assistant Professor of Learning Health Sciences.

Speaker:
Lauren A. Taylor, PhD, MDiv, MPH
Assistant Professor
Department of Population Health
Division of Medical Ethics
NYU Grossman School of Medicine

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Lecture / Discussion Wed, 25 May 2022 00:20:49 -0400 2022-06-21T12:00:00-04:00 2022-06-21T13:00:00-04:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion LHS Collaboratory logo
Alum|NUM (August 11, 2022 9:00am) https://events.umich.edu/event/95038 95038-21788375@events.umich.edu Event Begins: Thursday, August 11, 2022 9:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Physical
TBA

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Other Thu, 11 Aug 2022 18:15:34 -0400 2022-08-11T09:00:00-04:00 2022-08-11T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Merck symposium 2022 (August 18, 2022 9:00am) https://events.umich.edu/event/96202 96202-21792034@events.umich.edu Event Begins: Thursday, August 18, 2022 9:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Physical
Christopher Vanderwal (UC-Irvine)

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Other Thu, 18 Aug 2022 18:15:32 -0400 2022-08-18T09:00:00-04:00 2022-08-18T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Making Sense of Mechanisms: Studies on Learning Organic Chemistry (September 8, 2022 4:00pm) https://events.umich.edu/event/95970 95970-21791508@events.umich.edu Event Begins: Thursday, September 8, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Learning is a difficult, multidimensional process; educators have a responsibility to be aware of our students’ learning progress and respond to that awareness in ways that further promote learning. For the Raker Research Group, we are focused on understanding how novices develop and use the language of organic chemistry, i.e. how learners come to make sense of reaction mechanisms. This broader outcome for our course requires the activation and integration of multiple concepts and skills that have been shown to be difficult for learners. The focus of our work is on foundational concepts including acidity and basicity, and nucleophiles and electrophiles in the context of studying how learners make sense of mechanisms. We develop rubrics to measure learning and evaluate instruction, and construct learning experiences that supplement and complement instruction. We have been successful in using our rubrics to develop computer-based scoring models to evaluate 20,000+ written reaction mechanism explanations across the undergraduate organic chemistry curriculum. For our Lewis acid–base scoring model, we have demonstrated that the model can be deployed in adaptative tutorials to provide and promote targeted learning. While our work has specifically focused on organic chemistry, implications of our work extend to all areas of chemistry: to provide meaningful learning experiences for our students, we must have good tools to measure learning and work to create experiences that better and best promote that learning. Thus, molecular orbital diagrams in inorganic chemistry, phase diagrams in physical chemistry, or enzyme-substrate kinetics in biochemistry, for example, all provide contexts in our courses for reflecting on and responding to learning that requires integration of concepts and skills similar to how we do chemistry.




Jeffrey Raker (University of South Florida)

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Other Thu, 08 Sep 2022 18:15:32 -0400 2022-09-08T16:00:00-04:00 2022-09-08T17:15:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Science Communication Certificate Program (September 12, 2022 12:00pm) https://events.umich.edu/event/98347 98347-21796523@events.umich.edu Event Begins: Monday, September 12, 2022 12:00pm
Location:
Organized By: Futures in Research, Science, Teaching - FIRST

A science communication program run by the Museum of Natural History and the MCDB department. Create a video based on a past research project/experience to be shared on the Museum's website. Completion of the workshops and final video will earn a science communication certificate.

More details:
https://drive.google.com/file/d/1R0o_bkRGMgPn7L_MVSD_V4b3_j3p8a-Y/view?usp=sharing

Application deadline is Sept. 12th

Please email us with any questions:
SECOND.Contact@umich.edu

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Workshop / Seminar Thu, 08 Sep 2022 17:46:46 -0400 2022-09-12T12:00:00-04:00 2022-09-12T12:00:00-04:00 Futures in Research, Science, Teaching - FIRST Workshop / Seminar SECOND Science Communication
Illuminating the Biochemical Activity Architecture of the Cell (September 12, 2022 4:00pm) https://events.umich.edu/event/95569 95569-21790344@events.umich.edu Event Begins: Monday, September 12, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


Jin Zhang (University of California, San Diego)

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Other Mon, 12 Sep 2022 18:15:26 -0400 2022-09-12T16:00:00-04:00 2022-09-12T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
RNA Innovation Seminar: Zhipeng Lu, USC (September 12, 2022 4:00pm) https://events.umich.edu/event/97465 97465-21794615@events.umich.edu Event Begins: Monday, September 12, 2022 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

HYBRID SEMINAR:
In-person: BSRB, ABC seminar rooms
Zoom: https://umich.zoom.us/webinar/register/WN_ttcO3H-GR3yAJ8JONZegPg#/registration

Abstract: RNA in living cells are in constant motion, form dynamic structures, and interact with many molecules, including other RNAs. Direct determination of RNA structures and interactions in vivo is essential to understanding their functions, but has been challenging in the past. We developed a number of novel chemical and computational tools to capture the 2D and 3D RNA structurome and interactome in cells, providing a comprehensive view of RNA conformations that underlie their roles in gene regulation and human diseases. Applications of these methods revealed new mechanisms in lncRNA functions, RNA modifications and splicing regulation.

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Lecture / Discussion Fri, 26 Aug 2022 09:54:38 -0400 2022-09-12T16:00:00-04:00 2022-09-12T17:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion Zhipeng Lu (鲁志鹏), Ph.D., University of Southern California
Futures in Research, Science, and Teaching - General meeting (September 13, 2022 4:00pm) https://events.umich.edu/event/96044 96044-21791846@events.umich.edu Event Begins: Tuesday, September 13, 2022 4:00pm
Location:
Organized By: Futures in Research, Science, Teaching - FIRST

General meetings take place every other Tuesday from September 13 to December 6th. Events include:

September 13th: Pathways in Research (Graduate student/Faculty panel)
September 27th: Mixer (food provided)
October 11th: Poster design and presentation
October 25th: Applying to graduate school - application components and essay writing advice
November 8th: Finding paid summer and post-baccalaureate research opportunities
November 22nd: Faculty talk
December 6th: Mixer

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Meeting Mon, 12 Sep 2022 12:26:57 -0400 2022-09-13T16:00:00-04:00 2022-09-13T17:00:00-04:00 Futures in Research, Science, Teaching - FIRST Meeting Event flyer detailing date, time, and location: September 13th at 4 pm, BSB 1010
Graham DeRuiter (September 13, 2022 4:00pm) https://events.umich.edu/event/90523 90523-21671305@events.umich.edu Event Begins: Tuesday, September 13, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Inorganic
Graham DeRuiter

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Other Wed, 08 Jun 2022 12:15:08 -0400 2022-09-13T16:00:00-04:00 2022-09-13T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Catalyst RE-Design: Dynamic, Reactive, and Selective Systems for Oxygenated Polymer Synthesis (September 20, 2022 4:00pm) https://events.umich.edu/event/95777 95777-21790892@events.umich.edu Event Begins: Tuesday, September 20, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Polymer waste has quickly become one of our society\'s largest looming environmental concerns, where an estimated 4.9 GTons of polymer waste currently exist in the environment. Central to addressing this challenge is the generation of polymers with robust materials properties that embed or encode end-of-use. Oxygenated (co)polymers such as polyhydroxyalkanoates are naturally occurring and fully bioresorbable polymers with promising materials properties, yet their efficient and cost-effective stereospecific synthesis remains challenging. In this talk, I will share some of our group\'s recent advances in catalyst development for the synthesis of oxygenated (co)polymers. Specifically, we\'ll discuss how new catalyst design strategies which fully leverage the high metal-ligand lability of the rare-earth elements can lead to systems which are highly dynamic, reactive, and selective.

Jerome Robinson (Brown)

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Other Tue, 20 Sep 2022 18:15:24 -0400 2022-09-20T16:00:00-04:00 2022-09-20T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
DCMB Weekly Seminar (September 21, 2022 4:00pm) https://events.umich.edu/event/98815 98815-21797218@events.umich.edu Event Begins: Wednesday, September 21, 2022 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract:
The intersect between the life sciences (cells, tissues, organs) and engineered materials (polymers, biomacromolecules, semiconductors) is crucial for a wide range of medical and biotechnological applications. Hence, the precise control of biotic/abiotic interfaces has been one of the main obstacles of past decades. The Lahann Lab designs polymers for a range of different medical applications. In particular, we have developed a class of protein nanoparticles for targeting of glioblastoma. In addition, I will summarize our efforts related to sheet-like 3D organoid systems and will address recent advances with morphologically designed interfaces.

Research Interests:
Designer surfaces, advanced polymers, biomimetic materials, microfluidic devices, engineered microenvironments, nano-scale self-assembly.

Joerg Lahann’s research is broadly related to surface engineering with strong ties to biomedical engineering and nanotechnology. His research on reversibly switching surfaces was featured in an article in Science (J. Lahann, et al., A Reversibly Switching Surface, January 17, 2003, 299, 371-374.) These “smart surfaces” can reversibly switch properties in response to an external stimulus. To demonstrate these findings, a surface design was developed that can be changed from water-attracting to water-repelling with the application of a weak electric field. Designed as a switch, single-layered molecular-level machines are aligned on a surface using self-assembly and then are flipped between defined microscopic states. This type of surface design may offer a new paradigm for interfacial engineering as it amplifies reversible conformational transitions at a molecular level to macroscopic changes in surface properties without altering the chemical identity of the surface.

Joerg has also developed a novel class of polymers with potential for biomimetic and spatially directed surface engineering. This “reactive coating” technology uses chemical vapor deposition (CVD) polymerization to deposit a wide range of chemical signatures on various substrate materials. Its simplicity in providing chemically reactive groups and its applicability to three-dimensional geometries (e.g., for microfluidics) enables the exact tailoring of surface properties and the preparation of biologically relevant microenvironments. Reactive coatings are compatible with soft lithographic processes, allowing for patterning of proteins, DNA, cytokines, and mammalian cells.

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Lecture / Discussion Thu, 15 Sep 2022 11:36:52 -0400 2022-09-21T16:00:00-04:00 2022-09-21T17:00:00-04:00 Palmer Commons DCMB Seminar Series Lecture / Discussion (Protein pattern deposited on a polymer surface, artistic rendering, credit: Bahar Dadfar)
LHS Collaboratory (September 22, 2022 12:00pm) https://events.umich.edu/event/96027 96027-21791723@events.umich.edu Event Begins: Thursday, September 22, 2022 12:00pm
Location: Palmer Commons
Organized By: Department of Learning Health Sciences

LHS Collaboratory Kickoff Poster Session Showcasing LHS Work at the University of Michigan

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Lecture / Discussion Tue, 12 Jul 2022 10:55:57 -0400 2022-09-22T12:00:00-04:00 2022-09-22T14:00:00-04:00 Palmer Commons Department of Learning Health Sciences Lecture / Discussion LHS Collaboratory logo
OHS Seminar Series Schedule (September 22, 2022 12:00pm) https://events.umich.edu/event/98131 98131-21795615@events.umich.edu Event Begins: Thursday, September 22, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

OHS Seminar Series Schedule Fall 2022 - Stay tuned for more updates!

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Presentation Tue, 06 Sep 2022 13:16:28 -0400 2022-09-22T12:00:00-04:00 2022-09-22T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Presentation OHS Seminar Series Schedule Fall 2022
Postdoc Appreciation Week – Special Presentations (September 22, 2022 12:00pm) https://events.umich.edu/event/98318 98318-21796492@events.umich.edu Event Begins: Thursday, September 22, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

Felicia Miranda, DDS, MS, PhD
Postdoctoral Fellow
Department of Orthodontics
University of Michigan School of Dentistry
Mentor: Lucia Cevidanes

Amanda Rodriguez, DDS, MS
Research Fellow & PiMA Program Assistant Director
Department of Periodontics and Oral Medicine
University of Michigan School of Dentistry
Mentors: Drs. Hsun-Liang Chan, DDS, MS and
Oliver Kripfgans, PhD

Hiroki Ueharu, Ph.D.
Department of Biologic & Materials Sciences and Prosthodontics, University of Michigan School of Dentistry
Mentor: Dr. Yuji Mishina

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Presentation Thu, 08 Sep 2022 12:20:48 -0400 2022-09-22T12:00:00-04:00 2022-09-22T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Presentation Postdoc Appreciation Week – Special Presentations
PBBs in Michigan: Empowering an Exposed Community (September 27, 2022 12:00pm) https://events.umich.edu/event/98897 98897-21797325@events.umich.edu Event Begins: Tuesday, September 27, 2022 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Featuring Bonnie Havlicek, RN (Co-Chair PBB Advisory Board) and Michele Marcus, PhD, MPH (Professor, Departments of Epidemiology, Environmental Health & Pediatrics, Schools of Public Health and Medicine, Emory University). Moderated by Amy Schulz, PhD (M-LEEaD CEC Core Leader, UM SPH).

Registration required for Zoom webinar https://bit.ly/3Le7hby

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Workshop / Seminar Fri, 16 Sep 2022 16:26:51 -0400 2022-09-27T12:00:00-04:00 2022-09-27T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Workshop / Seminar Residents & Researchers Tuesday Talks
Futures in Research, Science, and Teaching - General meeting (September 27, 2022 4:00pm) https://events.umich.edu/event/96044 96044-21791847@events.umich.edu Event Begins: Tuesday, September 27, 2022 4:00pm
Location:
Organized By: Futures in Research, Science, Teaching - FIRST

General meetings take place every other Tuesday from September 13 to December 6th. Events include:

September 13th: Pathways in Research (Graduate student/Faculty panel)
September 27th: Mixer (food provided)
October 11th: Poster design and presentation
October 25th: Applying to graduate school - application components and essay writing advice
November 8th: Finding paid summer and post-baccalaureate research opportunities
November 22nd: Faculty talk
December 6th: Mixer

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Meeting Mon, 12 Sep 2022 12:26:57 -0400 2022-09-27T16:00:00-04:00 2022-09-27T17:00:00-04:00 Futures in Research, Science, Teaching - FIRST Meeting Event flyer detailing date, time, and location: September 13th at 4 pm, BSB 1010
Investigating Sociocultural and Environmental Factors Related to Students’ Chemistry Identity Development (September 27, 2022 4:00pm) https://events.umich.edu/event/94228 94228-21726176@events.umich.edu Event Begins: Tuesday, September 27, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

ChemEd
Justin Carmel (Florida International University)

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Other Tue, 27 Sep 2022 18:15:25 -0400 2022-09-27T16:00:00-04:00 2022-09-27T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
OHS Seminar Series Schedule (September 29, 2022 12:00pm) https://events.umich.edu/event/98131 98131-21795616@events.umich.edu Event Begins: Thursday, September 29, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

OHS Seminar Series Schedule Fall 2022 - Stay tuned for more updates!

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Presentation Tue, 06 Sep 2022 13:16:28 -0400 2022-09-29T12:00:00-04:00 2022-09-29T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Presentation OHS Seminar Series Schedule Fall 2022
10th Anniversary Symposium & Celebration - Department of Computational Medicine & Bioinformatics (September 29, 2022 1:15pm) https://events.umich.edu/event/98793 98793-21797190@events.umich.edu Event Begins: Thursday, September 29, 2022 1:15pm
Location: Taubman Biomedical Science Research Building
Organized By: Omenn Lecture

On September 29, 2022, the University of Michigan Department of Computational Medicine and Bioinformatics (DCMB) will celebrate its 10th anniversary with a symposium and in-person gathering.

The event will be introduced by James Woolliscroft, M.D., Lyle C. Roll Professor of Medicine, and former dean of the Medical School. Department faculty members will present about their research, and two distinguished alumni –Erin Shellman, Ph.D., Head of Data at Gingko Bioworks, and Dan Rhodes, Ph.D., co-founder and CEO at Strata Oncology – will talk about their respective careers.

At 4:00 p.m., Holden Thorp, Ph.D., editor-in-chief, Science Family of Journals will give the 8th Annual G. Omenn Lecture: "Data Science and Medicine in the Age of Open Data, Open Code, and Open Access: From Protein Structure Prediction to COVID Origins"

A poster session will close the afternoon. For more information and registration, visit our website.

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Lecture / Discussion Wed, 14 Sep 2022 16:17:20 -0400 2022-09-29T13:15:00-04:00 2022-09-29T18:30:00-04:00 Taubman Biomedical Science Research Building Omenn Lecture Lecture / Discussion DCMB 10th Anniversary Symposium & Celebration
Incorporation and molecular level consequences of mRNA modifications (September 29, 2022 4:00pm) https://events.umich.edu/event/96495 96495-21792591@events.umich.edu Event Begins: Thursday, September 29, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Cells face the daunting task of maintaining the right number of proteins, at the right time, under rapidly changing conditions. One way that nature accomplishes this is by chemically modifying DNA, RNA and protein molecules to control their structure, function, stability and localization. A single cell possesses thousands of enzymatically modified RNA sites. These modifications have the potential to directly impact protein production, and disruptions in the RNA modification landscape are associated with an array of diseases including cancers, neurological diseases, and diabetes. Nonetheless, it remains to be discovered how individual sites of modification influence the function of a given RNA. We are working to ascertain how modifications to the molecular blueprints for protein synthesis, messenger RNAs (mRNAs), influence protein production. Our studies have led to the discovery of new mRNA modifications, reframed the current model for RNA modifying enzyme target selection, and identified modifications that change the speed and accuracy of protein synthesis. These findings lay the foundation for establishing complex rules governing the molecular level consequences of mRNA modifications.
Kristin Koutmou

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Other Thu, 29 Sep 2022 18:15:25 -0400 2022-09-29T16:00:00-04:00 2022-09-29T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Natural Product Discovery and Biosynthesis in the Post-genomic Era (October 4, 2022 4:00pm) https://events.umich.edu/event/94405 94405-21738304@events.umich.edu Event Begins: Tuesday, October 4, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Chembio
Mohammad Seyedsayamdost (Princeton)

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Other Tue, 04 Oct 2022 18:15:24 -0400 2022-10-04T16:00:00-04:00 2022-10-04T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
DCMB / CCMB Weekly Seminar (October 5, 2022 4:00pm) https://events.umich.edu/event/99751 99751-21798643@events.umich.edu Event Begins: Wednesday, October 5, 2022 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract:

Accurately predicting the onset of disease is a major challenge in clinical medicine because the genesis of diseases is generally a complex and dynamic process. Wearable sensor technologies provide an unprecedented opportunity to collect physiological data at orders of magnitude higher high time-resolution than conventional clinical practice. This provides unprecedented opportunities for investigating the dynamics of disease processes and may usher in a new era of real-time, personalized medicine. We have proposed the potential of real-time, continuously measured physiological data as a non-invasive, “digital biomarker” approach for detecting the earliest stages in transition to a disease state. In this talk, I will describe an example of our interdisciplinary team’s work on this topic that uses the early detection and possible prediction of febrile (i.e., fever-associated) adverse events in cancer events as an important application.

Clinical Interests
Prostate Cancer, General Oncology, Biomarkers in Oncology
Research Interests
• Biology of circulating, extracellular nucleic acids and translational applications
• Developing next generation approaches for early detection and monitoring of cancer
• Bioinformatics and computational biology, high-throughput sequencing
• New technologies to enable cancer detection and monitoring

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Lecture / Discussion Mon, 03 Oct 2022 15:21:48 -0400 2022-10-05T16:00:00-04:00 2022-10-05T17:00:00-04:00 Palmer Commons DCMB Seminar Series Lecture / Discussion Muneesh Tewari, MD, PhD
MS / PhD Open House (October 5, 2022 5:00pm) https://events.umich.edu/event/98232 98232-21795760@events.umich.edu Event Begins: Wednesday, October 5, 2022 5:00pm
Location: Palmer Commons
Organized By: U-M College of Pharmacy

Explore programs in drug discovery, delivery, and optimization.

Learn about our PhD programs in:
Medicinal Chemistry
Pharmaceutical Sciences
Clinical Pharmacy Translational Science

and our MS program in Integrated Pharmaceutical Sciences.

The event will include overview presentations regarding each program as well as a poster session featuring research presentations by our graduate students.

The MS/PhD Open House will be hosted in both in-person and virtual formats. We hope that you will make plans to attend!

If you have any questions, please contact Cherie Dotson at crdotson@umich.edu

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Reception / Open House Wed, 07 Sep 2022 14:17:55 -0400 2022-10-05T17:00:00-04:00 2022-10-05T19:00:00-04:00 Palmer Commons U-M College of Pharmacy Reception / Open House Text: advance your education.
Deciphering mechanisms of organismal phosphate regulation (October 6, 2022 12:00pm) https://events.umich.edu/event/98813 98813-21797217@events.umich.edu Event Begins: Thursday, October 6, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

EDUCATION
Massachusetts Institute of Technology, Cambridge, MA, USA
Doctor of Philosophy in Biology, September 2007-June 2014
University of Washington, Seattle, WA, USA
Honors Bachelor of Science in Neurobiology, September 2002-June 2006
POSITIONS AND ACADEMIC APPOINTMENTS
2021-Present Assistant Professor, University of Michigan School of Dentistry
2022-Present Faculty Member, Cellular and Molecular Biology Graduate Program, University of Michigan
2019-2021 Instructor in Medicine, Harvard Medical School, Massachusetts General Hospital, Boston, MA
2017-2019 Research Fellow, Endocrine Unit, Lab of Dr. Michael Mannstadt, MGH, Boston, MA
2015-2017 Postdoctoral Associate, Department of Molecular and Cellular Biology, Lab of Dr. Erin O’Shea,

Harvard University, Cambridge, MA

2007-2014 Graduate Research Fellow, Department of Biology, Lab of Dr. Laurie Boyer, MIT, Cambridge, MA
2006 Research Assistant, Department of Orthobiology, Lab of Dr. Mary Murphy,

National University of Ireland, Galway, Ireland

2005-2006 Undergraduate Research Fellow, Department of Genome Sciences, Lab of Dr. Leo Pallanck,

University of Washington, Seattle, WA

2003-2005 Undergraduate Research Fellow, Department of Biochemistry, Lab of Dr. Brian Kennedy,

University of Washington, Seattle, WA
ACADEMIC AND PROFESSIONAL HONORS
2021 University of Michigan Biological Sciences Scholar, Ann Arbor, MI
2019 Most Outstanding Poster, Bisphosphonates 50th Anniversary Meeting
2018 Endocrine Fellows Foundation Forum Travel Grant, Fellows Forum on Metabolic Bone Disease
2018 AIMM-ASBMR John Haddad Young Investigator Fellow
2017 American Society for Bone and Mineral Research Young Investigator Travel Grant Award,
2019 MIT Vertex Scholar, Cambridge, MA
2007 MIT Presidential Scholar
2006 University of Washington Herschel and Caryl Roman Undergraduate Science Scholar
2006 University of Washington Mary Gates Research Scholar
GRANTS AND FELLOWSHIPS
Current
NIH/NIAMS K99/R00 Pathway to Independence Award,
K99 period: August 2019-Sept 2021, R00 period: Feb 2022-Jan 2025
Title: Deciphering mechanisms of nitrogen-containing bisphosphonates, R00 funding: $249,000/year for 3 years

Previous
2018-2019 NIH T32 Training Grant Trainee, 2018-2019, Endocrinology Division, Massachusetts General Hospital
2017 American Cancer Society Postdoctoral Fellowship, 2017
PUBLICATIONS
Bondeson, D.P., Paolella, B.R., Asfaw, A., Rothberg, M., Skipper, T., Mesa, G., Gonzalez, A., Surface, L.E., Ito, K.,
Kazachkova, M., Colgan, W.N., Warren, A., Dempster, J., Krill-Burger, J., Ericsson, M., Tang, A., Fung, I., Chambers,
E.S., Abdusamad, M., Dumont, N., Doench, J.G., Piccioni, F., Root, D.R., Boehm, J., Hahn, W.C, Mannstadt, M.,
McFarland, J.M., Vazquez, F., Golub, T.R., (2022) Phosphate dysregulation via the XPR1:KIDINS220 protein
complex is a therapeutic vulnerability in ovarian cancer., Nature Cancer, 6:681-695

Surface,L.E., Burrow, D.T., Li, J., Park, J., Kumar, S., Lyu, C., Song, N., Yu, Z., Rajagopal, A., Bae, Y., Lee, B.H.,
Mumm, S., Gu, C., Baker, J.C., Mohseni, M., Sum, M., Huskey, M., Duan, S., Bijanki, V.N., Civitelli, R., Gardner,
M.J., McAndrew, C.M., Ricci, W.M., Gurnett, C.A., Diemer, K., Wan, F., Costantino, C.L., Shannon, K.M., Raje, N.,
Dodson, T.B., Haber, D.A., Carette, J.E., Varadarajan, M., Brummelkamp, T.R., Birsoy, K., Sabatini, D.M., Haller, G.,
Peterson, T.R., (2020) ATRAID regulates the action of nitrogen-containing bisphosphonates on bone. Science
Translational Medicine, 12:544, eaav9166
Yu, Z., Surface, L.E., Park, C.Y., Horlbeck, M.A., Wyant, G.A., Abu-Remaileh, M., Peterson, T.R., Sabatini, D.M.,
Weissman, J.S., O’Shea, E.K., (2018) Identification of a transporter complex responsible for the cytosolic entry of
nitrogen-containing bisphosphonates. Elife 7:e36620
Surface, L.E.*, Fields, P.F*, Subramanian, V., Behmer, R., Udeshi, N., Peach, S.E., Carr, S.A., Jaffe, J.D., Boyer, L.A.
(2016) H2A.Z.1 monoubiquitylation antagonizes BRD2 to maintain poised chromatin in ESCs. Cell Reports, 14, 1142-
1155. *equal contribution
Subramanian, V., Mazumder, A., Surface, L.E., Butty, V.L., Fields, P.A., Alwan, A., Torrey, L., Thai, K.K., Levine,
S.S., Bathe, M., Boyer, L.A. (2013) H2A.Z acidic patch couples chromatin dynamics to regulation of gene expression
programs during ESC differentiation. PLoS Genetics, 9, e1003725
Klattenhoff, C*., Sheuermann, J.C.*, Surface, L.E., Bradley, R.K., Fields, P., Steinhauser, M.L., Ding, H., Butty, V.L.,

Torrey, L., Haas S., Abo, R., Tabebordbar, M., Lee, R.T., Burge, C.B., Boyer, L.A. (2013) Braveheart, a long non-
coding RNA required for cardiovascular lineage commitment. Cell 152, 1-14. *equal contribution

Surface, L.E.*, Thornton, S.R.*, Boyer, L.A. (2010) Polycomb group proteins set the stage for early lineage
commitment. Cell Stem Cell 7, 288-298. *equal contribution
Lockshon, D., Surface L.E., Kerr, E.O., Kaeberlein, M., Kennedy, B.K. (2007). The sensitivity of yeast mutants to
oleic acid implicates the peroxisome and other processes in membrane function. Genetics 175, 77-91.
SERVICE & OUTREACH EXPERIENCE
Member, American Society of Bone and Mineral Research, Early Stage Investigator Committee, 2022-Present
Member, Oral Health Sciences PhD Program Committee University of Michigan, 2022-Present
Abstract Reviewer, American Society of Bone and Mineral Research, Annual Meeting, 2020-Present
Workshop Committee Member, Center for Skeletal Research, 2019-2021
-Plan instructional workshops for the Boston-area skeletal research community.
Grant Reviewer, Seeding Labs (Non-profit science development organization), Boston, MA, 2016-Present
-Review grant applications for instrument access grants provided to laboratories in developing countries
-Contributed to data analysis of existing grants
Mentor, Science Club for Girls, Roxbury, MA, 2015-2019
-Led middle school girls from diverse backgrounds in weekly science clubs on Saturdays to engage them with
science and technology
Postdoc Liason Committee, Harvard Department of Molecular and Cellular Biology, 2015-2017
-Served on a committee that advocates for issues relevant for postdocs and beyond. Advocated for the
department to consider a preprint server policy, and bringing in a more diverse set of scientists for talks.
Science Fair Judge, Quincy High School, Quincy, MA, 2010-2021
-Judged the science fair of a diverse high school near Boston, and spoke with attendees about my own career
path through science.

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Lecture / Discussion Thu, 15 Sep 2022 11:20:30 -0400 2022-10-06T12:00:00-04:00 2022-10-06T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Lecture / Discussion Lauren Surface, PhD
OHS Seminar Series Schedule (October 6, 2022 12:00pm) https://events.umich.edu/event/98131 98131-21795617@events.umich.edu Event Begins: Thursday, October 6, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

OHS Seminar Series Schedule Fall 2022 - Stay tuned for more updates!

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Presentation Tue, 06 Sep 2022 13:16:28 -0400 2022-10-06T12:00:00-04:00 2022-10-06T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Presentation OHS Seminar Series Schedule Fall 2022
Electrifying Material and Organic Synthesis (October 6, 2022 4:00pm) https://events.umich.edu/event/95988 95988-21791685@events.umich.edu Event Begins: Thursday, October 6, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Analytical
Long Luo (Wayne State University)

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Other Thu, 06 Oct 2022 18:15:24 -0400 2022-10-06T16:00:00-04:00 2022-10-06T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
CGIS Study Abroad Fair (October 11, 2022 12:00pm) https://events.umich.edu/event/96881 96881-21793528@events.umich.edu Event Begins: Tuesday, October 11, 2022 12:00pm
Location: Michigan Union
Organized By: Center for Global and Intercultural Study

Learn about 115+ programs in over 45 countries, ask about U-M faculty-led programs, and figure out which program can help satisfy your major/minor requirements. CGIS has programs ranging from a few weeks to an academic year! Meet with CGIS advisors, staff from the Office of Financial Aid and the LSA Scholarship Office, CGIS Alumni, and other on-campus offices who can help you select a program that works best for you.

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Fair / Festival Tue, 04 Oct 2022 11:40:54 -0400 2022-10-11T12:00:00-04:00 2022-10-11T16:00:00-04:00 Michigan Union Center for Global and Intercultural Study Fair / Festival Join us for the CGIS Study Abroad Fair on October 11, 2022
Addicted to Salt: Mass Spectrometry Reveals Chlorine Chemistry Degrading Wintertime Air Quality (October 11, 2022 4:00pm) https://events.umich.edu/event/96496 96496-21792592@events.umich.edu Event Begins: Tuesday, October 11, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Chlorine radicals (Cl·) readily react with the greenhouse gas methane and other volatile hydrocarbons, facilitating the production of ozone and particulate matter that degrade air quality and harm human health. An important chlorine source is the photolysis of nitryl chloride (ClNO2(g)), which is formed in the polluted atmosphere at night through the reaction of dinitrogen pentoxide (N2O5(g)) with chloride-containing surfaces. The importance of ClNO2 in marine and coastal locations is well-recognized due to presence of sea spray aerosol. However, ClNO2 was unexpectedly detected in regions far inland from the ocean, with wintertime levels rivaling marine locations. We tackled investigation of this unresolved chemistry through a series of field-based measurements of atmospheric trace gases, individual particles, and snow, complemented by “lab-in-the-field” experiments and modeling, in wintertime urban environments. Our novel single-particle measurements, combined with online ion chromatography, identified road salt aerosol as the dominant chloride source. ClNO2 production from the reaction of N2O5 with road salt aerosol was quantitatively observed by chemical ionization mass spectrometry. We also exposed road salt-contaminated snow to synthesized N2O5 and observed ClNO2 production, discovering yet another unique chloride source in the wintertime inland environment. We showed that ClNO2 produced from the saline snowpack alters air quality even hundreds of meters above the snow-covered ground. Our discovery of the connection between road salt and wintertime air quality has profound implications for wintertime atmospheric chemistry and decision-making regarding deicing practices, as tens of millions of tons of road salt are spread on roadways for deicing globally each winter.


Kerri Pratt

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Other Tue, 11 Oct 2022 18:15:21 -0400 2022-10-11T16:00:00-04:00 2022-10-11T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Futures in Research, Science, and Teaching - General meeting (October 11, 2022 4:00pm) https://events.umich.edu/event/96044 96044-21791848@events.umich.edu Event Begins: Tuesday, October 11, 2022 4:00pm
Location:
Organized By: Futures in Research, Science, Teaching - FIRST

General meetings take place every other Tuesday from September 13 to December 6th. Events include:

September 13th: Pathways in Research (Graduate student/Faculty panel)
September 27th: Mixer (food provided)
October 11th: Poster design and presentation
October 25th: Applying to graduate school - application components and essay writing advice
November 8th: Finding paid summer and post-baccalaureate research opportunities
November 22nd: Faculty talk
December 6th: Mixer

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Meeting Mon, 12 Sep 2022 12:26:57 -0400 2022-10-11T16:00:00-04:00 2022-10-11T17:00:00-04:00 Futures in Research, Science, Teaching - FIRST Meeting Event flyer detailing date, time, and location: September 13th at 4 pm, BSB 1010
Poster Design Workshop (October 11, 2022 4:00pm) https://events.umich.edu/event/99872 99872-21798816@events.umich.edu Event Begins: Tuesday, October 11, 2022 4:00pm
Location: Biological Sciences Building
Organized By: Futures in Research, Science, Teaching - FIRST

A short presentation on STEM poster design, followed by researchers and graduate students sharing personal examples. Topics will included formatting, narrating your research story, and designing a poster that works equally well presented or read on its own.

RSVP: https://forms.gle/DVGvnsSXhtCEBeWy6

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Workshop / Seminar Wed, 05 Oct 2022 13:46:21 -0400 2022-10-11T16:00:00-04:00 2022-10-11T17:00:00-04:00 Biological Sciences Building Futures in Research, Science, Teaching - FIRST Workshop / Seminar FIRST Logo
Ab-initio solid state chemistry as a new frontier of theory (October 12, 2022 4:00pm) https://events.umich.edu/event/96497 96497-21792593@events.umich.edu Event Begins: Wednesday, October 12, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The search for new materials is at the core of the technological advancement of our society. While many newly synthesized materials can be analyzed by current quantum chemical techniques, mostly based on the density functional theory (DFT), there is a large number of materials that cannot be treated successfully by existing methodologies. This is mostly due to the presence of strong electron correlation, relativistic effects, and disorder. These materials require a post-DFT description that explicitly includes electron-electron interactions.

In my talk, I will discuss current theoretical challenges in the study of solid state materials and I will describe my group's contributions to the development of post-DFT methods. In the first part, I will present the newest relativistic methodologies for solids. In the second part, I will talk about the treatment of strongly correlated electrons residing in d- and f-orbitals of crystals with transition metals. Finally, I will sketch future directions for computational ab-initio solid state chemistry.


Dominika Zgid

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Other Wed, 12 Oct 2022 18:15:27 -0400 2022-10-12T16:00:00-04:00 2022-10-12T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
DCMB / CCMB Weekly Seminar (October 12, 2022 4:00pm) https://events.umich.edu/event/99377 99377-21797973@events.umich.edu Event Begins: Wednesday, October 12, 2022 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract:

Our current understanding of how genes are regulated is akin to solving a jigsaw puzzle. Many factors governing gene expression have been identified, and researchers have collected a wide variety of related datasets. However, how these "parts" are pieced together to function as a whole remains unclear. In this talk, I will discuss our research to develop and apply state-of-the-art machine learning methods to genomics datasets to attempt to put together the pieces from the data. I will cover our work using deep learning architecture that captures the data's underlying structure to integrate datasets and connect them to gene expression via the prediction task. We also interpret the prediction results and tie them back to contributing factors to develop potential hypotheses related to gene regulation. I will then move from bulk data to the single-cell data domain and discuss methods to perform unsupervised integration of different types of single-cell experiments. This talk aims to highlight our research direction's potential to reveal the important gene regulatory mechanisms in characterizing cell types and diseases from the collected data.

Bio:

Ritambhara Singh is an Assistant Professor in the Computer Science department and a faculty member of the Center for Computational Molecular Biology at Brown University. Her research lab works at the intersection of machine learning and biology. Prior to joining Brown, Singh was a post-doctoral researcher in the Noble Lab at the University of Washington. She completed her Ph.D. in 2018 from the University of Virginia with Dr. Yanjun Qi as her advisor. Her research has involved developing machine learning algorithms for the analysis of biological data as well as applying deep learning models to novel biological and biomedical applications. She recently received the NHGRI Genomic Innovator Award for developing deep learning methods to integrate and model genomics datasets. URL: https://vivo.brown.edu/display/rsingh47

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Lecture / Discussion Tue, 27 Sep 2022 09:32:07 -0400 2022-10-12T16:00:00-04:00 2022-10-12T17:00:00-04:00 Palmer Commons DCMB Seminar Series Lecture / Discussion Ritambhara Singh, Asst. Professor (Brown University)
Glucose metabolism in bone biology and diabetic osteopenia (October 13, 2022 12:00pm) https://events.umich.edu/event/98788 98788-21797183@events.umich.edu Event Begins: Thursday, October 13, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

I have been studying skeletal development and homeostasis for over 25 years. I am interested in understanding the molecular and metabolic regulation of skeletal cell types both in the embryo and in adults under normal or pathological conditions. The work has led to new insights into the metabolic features of chondrocytes, osteoblasts and osteoclasts. Studies of Hh, Wnt, Bmp and Notch signaling have uncovered metabolic reprogramming as a common link for developmental signals to regulate the fate and activity of skeletal cells. In a separate line of work, we have sought to elucidate the molecular identify and regulation of mesenchymal stem and progenitor cells in bone. This pursuit has led to the discovery of Gli1+ mesenchymal progenitors as the main source for osteoblasts in growing bones (Shi et al., 2017, Nat Commun., PMC
5725597). More recently, we have demonstrated a critical role for the Gli1+ progenitors in mediating the bone
anabolic role of teriparatide, the main bone anabolic therapy for osteoporosis (Shi et al, 2021, Cell Rep, in
press). The current proposal extends our work on mesenchymal progenitors and builds on the discovery of a
potential adipo-osteoprogenitor in the adult bone marrow. Completion of the proposed study is expected to
uncover the role of the newly discovered progenitors in bone homeostasis, skeletal aging and diabetic
osteopenia.

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Lecture / Discussion Thu, 15 Sep 2022 09:48:26 -0400 2022-10-13T12:00:00-04:00 2022-10-13T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Lecture / Discussion Fanxin Long, PhD William W. Smith Endowed Chair in Pediatric Genomic Research The Children's Hospital of Philadelphia Professor of Orthopedic Surgery University of Pennsylvania
OHS Seminar Series Schedule (October 13, 2022 12:00pm) https://events.umich.edu/event/98131 98131-21795618@events.umich.edu Event Begins: Thursday, October 13, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

OHS Seminar Series Schedule Fall 2022 - Stay tuned for more updates!

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Presentation Tue, 06 Sep 2022 13:16:28 -0400 2022-10-13T12:00:00-04:00 2022-10-13T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Presentation OHS Seminar Series Schedule Fall 2022
Celebrate Invention (October 13, 2022 1:00pm) https://events.umich.edu/event/98346 98346-21796522@events.umich.edu Event Begins: Thursday, October 13, 2022 1:00pm
Location: Michigan Union
Organized By: Innovation Partnerships

Celebrate University of Michigan inventors and the growing impact of U-M innovations!

Don’t miss this year’s annual Celebrate Invention highlighting demonstrations from promising U-M startups, networking opportunities at the ecosystem fair, panel discussions featuring prominent inventors and alumni, and the presentation of the Distinguished University Innovator of the Year Award.

Thursday, October 13
1:00–6:00pm
Michigan Union, 2nd Floor
530 S. State Street, Ann Arbor, MI 48109

Part of Ann Arbor SPARK's a2Tech360, Celebrate Invention is free and open to the public. Register today at *https://myumi.ch/DJNbM!*

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1:00–3:00pm: Panel Sessions & Ecosystem Fair

3:00–6:00pm: Reception, Rogel Ballroom, Michigan Union, 2nd Floor

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Reception / Open House Thu, 08 Sep 2022 17:06:20 -0400 2022-10-13T13:00:00-04:00 2022-10-13T18:00:00-04:00 Michigan Union Innovation Partnerships Reception / Open House Image of the Celebrate Invention logo on a blue background.
TBA (October 13, 2022 4:00pm) https://events.umich.edu/event/94377 94377-21736322@events.umich.edu Event Begins: Thursday, October 13, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Analytical
Mark Schoenfisch

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Other Fri, 09 Sep 2022 12:16:25 -0400 2022-10-13T16:00:00-04:00 2022-10-13T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Novartis Symposium (October 18, 2022 9:00am) https://events.umich.edu/event/94715 94715-21762085@events.umich.edu Event Begins: Tuesday, October 18, 2022 9:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry


Peter Seeberger(Max-PLanck Institute for Colloids and Interfaces) , Ellen Sletten(UCLA) , Atwood Cheung

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Other Tue, 18 Oct 2022 18:15:26 -0400 2022-10-18T09:00:00-04:00 2022-10-18T17:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
DCMB / CCMB Weekly Seminar (October 19, 2022 4:00pm) https://events.umich.edu/event/99817 99817-21798751@events.umich.edu Event Begins: Wednesday, October 19, 2022 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract:
Genome-wide association studies (GWAS) successfully identified more than a hundred genomic regions that contribute to schizophrenia risk. However, extracting biological mechanisms from GWAS is a challenge, because the majority of common risk variants reside in noncoding regions of the genome. In this talk, I will outline how high-resolution 3D maps of chromatin contacts in the human brain permit large-scale annotation of non-coding variants. In particular, I will introduce a novel platform that my lab has developed, Hi-C-coupled MAGMA (H-MAGMA), that annotates GWAS by incorporating chromatin interaction profiles from human brain tissue. While H-MAGMA identified neurobiologically relevant target genes for psychiatric disorders, application of H-MAGMA to schizophrenia GWAS identified thousands of genes to be associated with schizophrenia, necessitating the need for refining variants. To this end, we performed a massively parallel reporter assay (MPRA) on schizophrenia risk variants, from which we detected 440 variants with allelic regulatory activity. Characterization of these functional regulatory variants provided previously unknown regulatory principles of schizophrenia.

Short bio:
Hyejung Won is an Assistant Professor in the Department of Genetics and Neuroscience Center at the University of North Carolina at Chapel Hill. She received her B.S. and Ph.D. in Biology from Korea Advanced Institute of Science and Technology (KAIST), where she conducted research revealing the underlying mechanism of neurodevelopmental conditions using genetically modified mice under the supervision of Dr. Eunjoon Kim. She then joined Dr. Dan Geschwind’s group at UCLA, where she established Hi-C, a genome-wide chromosome conformation capture technology, and generated chromatin interaction profiles from the developing and adult human brain. Her lab leverages the genomics approach to bridge the gap between genetic risk factors and neurobiological mechanisms by mapping genetic variants of unknown function to the genes that they regulate, and identifying how dysfunctional gene regulation contributes to disease pathogenesis. Hyejung is the recipient of the NIH Director’s New Innovator Award, HHMI Gilliam Fellowship, NIH Pathway to Independence Award, and a NARSAD Young Investigator Award. She is also an active participant of the Impact of Genomic Variation on Function (IGVF) and PsychENCODE consortia.

Zoom link: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Lecture / Discussion Tue, 04 Oct 2022 13:40:56 -0400 2022-10-19T16:00:00-04:00 2022-10-19T17:00:00-04:00 Palmer Commons DCMB Seminar Series Lecture / Discussion Hyejung Won, PhD
LHS Collaboratory (October 20, 2022 12:00pm) https://events.umich.edu/event/96028 96028-21791725@events.umich.edu Event Begins: Thursday, October 20, 2022 12:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Speakers:
Alex John London, PhD
Professor of Ethics and Philosophy
Director of the Center for Ethics and Policy at Carnegie Mellon University
Explainability Is Not the Solution to Structural Challenges to AI in Medicine

Explainability is often treated as a necessary condition for ethical applications of artificial intelligence (AI) in Medicine. In this brief talk I survey some of the structural challenges facing the development and deployment of effective AI systems in health care to illustrate some of the limitations to explainability in addressing these challenges. This talk builds on prior work (London 2019, 2022) to illustrate how ambitions for AI in health care likely require significant changes to key aspects of health systems.

Melissa McCradden, PhD, MHSc
Director of AI in Medicine
The Hospital for Sick Children
On the Inextricability of Explainability from Ethics: Explainable AI does not Ethical AI Make

Explainability is embedded into a plethora of legal, professional, and regulatory guidelines as it is often presumed that an ethical use of AI will require explainable algorithms. There is considerable controversy, however, as to whether post hoc explanations are computationally reliable, their value for decision-making, and the relational implications of their use in shared decision-making. This talk will explore the literature across these domains and argue that while post hoc explainability may be a reasonable technical goal, it should not be offered status as a moral standard by which AI use is judged to be ‘ethical.’

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Livestream / Virtual Sat, 01 Oct 2022 17:10:43 -0400 2022-10-20T12:00:00-04:00 2022-10-20T13:30:00-04:00 Off Campus Location Department of Learning Health Sciences Livestream / Virtual LHS Collaboratory logo
OHS Seminar Series Schedule (October 20, 2022 12:00pm) https://events.umich.edu/event/98131 98131-21795619@events.umich.edu Event Begins: Thursday, October 20, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

OHS Seminar Series Schedule Fall 2022 - Stay tuned for more updates!

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Presentation Tue, 06 Sep 2022 13:16:28 -0400 2022-10-20T12:00:00-04:00 2022-10-20T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Presentation OHS Seminar Series Schedule Fall 2022
Rock, Paper, Scissors: The oral microbiome at the intersection of genotypic, anthropogenic and systemic factors (October 20, 2022 12:00pm) https://events.umich.edu/event/99963 99963-21798941@events.umich.edu Event Begins: Thursday, October 20, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

As a dual-trained periodontist and microbial ecologist, I use my clinical skills and training in ‘-omics’ research to investigate the myriad ways in which the human microbiome can be harnessed to promote health. I firmly believe that oral health and systemic diseases are intricately connected, and that global health can only be achieved when physicians and dentists collaborate to identify at-risk individuals and deliver integrated care.

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Lecture / Discussion Fri, 07 Oct 2022 10:59:44 -0400 2022-10-20T12:00:00-04:00 2022-10-20T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Lecture / Discussion Purnima Kumar, DDS, PhD