Happening @ Michigan https://events.umich.edu/list/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. U-M Health Sciences 2021 MLK Keynote (January 18, 2021 12:00pm) https://events.umich.edu/event/79757 79757-20484063@events.umich.edu Event Begins: Monday, January 18, 2021 12:00pm
Location: Off Campus Location
Organized By: School of Kinesiology

Bodies represent the sites of socially constructed differences and power relations. As such, the personal is political, and bodies are subject to political interpretations. Body politics based on racial (and/or ethnic) ascriptions (along with other intersecting elements such as sex, gender, sexuality, age, social class, ability, etc.) have adversely affected the overall health and wellness of bodies of Color in general, and Black bodies in particular - impacting their abilities, opportunities, access (inclusion/exclusion), care/treatment, and the overall nature of their lived experiences. Consequently, racialed body politics have contributed to an array of health disparities being more pronounced in communities of Color. However, movement offers a variety of health benefits and is therefore, a source of empowerment for racially politicized bodies.

This event will feature a keynote presentation by Dr. Monique Butler, U-M Kinesiology alumna and Chief Medical Officer for HCA Healthcare North Florida Division. She will address the theme "Where Do We Go From Here: Body Politics and Movement Towards Racial Empowerment."

This event is sponsored by the U-M Health Sciences units and hosted by the School of Kinesiology.

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Lecture / Discussion Tue, 05 Jan 2021 16:27:06 -0500 2021-01-18T12:00:00-05:00 2021-01-18T13:30:00-05:00 Off Campus Location School of Kinesiology Lecture / Discussion U-M Health Sciences 2021 MLK Keynote - Where Do We Go From Here: Body Politics and Movement Towards Racial Empowerment - with Dr. Monique Butler, MD
KNOWLEDGE EXTRACTION TO ACCELERATE SCIENTIFIC DISCOVERY (January 18, 2021 4:00pm) https://events.umich.edu/event/79534 79534-20373071@events.umich.edu Event Begins: Monday, January 18, 2021 4:00pm
Location: Off Campus Location
Organized By: Michigan Institute for Data Science

To combat COVID-19, clinicians and scientists all need to digest the vast amount of relevant biomedical knowledge in literature to understand the disease mechanism and the related biological functions. The first challenge is quantity. For example, nearly 2.7K new papers are published at PubMed per day. This knowledge bottleneck causes significant delay in the development of vaccines and drugs for COVID-19. The second challenge is quality due to the rise and rapid, extensive publications of preprint manuscripts without pre-publication peer review. Many research results about coronavirus from different research labs and sources are redundant, complementary or event conflicting with each other.

Let’s consider drug repurposing as a case study. Besides the long process of clinical trial and biomedical experiments, another major cause for the long process is the complexity of the problem involved and the difficulty in drug discovery in general. The current clinical trials for drug re-purposing mainly rely on symptoms by considering drugs that can treat diseases with similar symptoms. However, there are too many drug candidates and too much misinformation published from multiple sources. In addition to a ranked list of drugs, clinicians and scientists also aim to gain new insights into the underlying molecular cellular mechanisms on Covid-19, and which pre-existing conditions may affect the mortality and severity of this disease.

To tackle these two challenges, we have developed a novel and comprehensive knowledge discovery framework, COVID-KG, to accelerate scientific discovery and build a bridge between clinicians and biology scientists. COVID-KG starts by reading existing papers to build multimedia knowledge graphs (KGs), in which nodes are entities/concepts and edges represent relations involving these entities, extracted from both text and images. Given the KGs enriched with path ranking and evidence mining, COVID-KG answers natural language questions effectively. Using drug repurposing as a case study, for 11 typical questions that human experts aim to explore, we integrate our techniques to generate a comprehensive report for each candidate drug. Preliminary assessment by expert clinicians and medical school students show our generated reports are informative and sound. I will also talk about our ongoing work to extend this framework to other domains including molecular synthesis and agriculture.

Bio:

Heng Ji is a professor at Computer Science Department, and an affiliated faculty member at Electrical and Computer Engineering Department of University of Illinois at Urbana-Champaign. She is also an Amazon Scholar. She received her B.A. and M. A. in Computational Linguistics from Tsinghua University, and her M.S. and Ph.D. in Computer Science from New York University. Her research interests focus on Natural Language Processing, especially on Multimedia Multilingual Information Extraction, Knowledge Base Population and Knowledge-driven Generation. She was selected as “Young Scientist” and a member of the Global Future Council on the Future of Computing by the World Economic Forum in 2016 and 2017. The awards she received include “AI’s 10 to Watch” Award by IEEE Intelligent Systems in 2013, NSF CAREER award in 2009, Google Research Award in 2009 and 2014, IBM Watson Faculty Award in 2012 and 2014 and Bosch Research Award in 2014-2018, and ACL2020 Best Demo Paper Award. She was invited by the Secretary of the U.S. Air Force and AFRL to join Air Force Data Analytics Expert Panel to inform the Air Force Strategy 2030. She is the lead of many multi-institution projects and tasks, including the U.S. ARL projects on information fusion and knowledge networks construction, DARPA DEFT Tinker Bell team and DARPA KAIROS RESIN team. She has coordinated the NIST TAC Knowledge Base Population task since 2010. She has served as the Program Committee Co-Chair of many conferences including NAACL-HLT2018. She is elected as the North American Chapter of the Association for Computational Linguistics (NAACL) secretary 2020-2021. Her research has been widely supported by the U.S. government agencies (DARPA, ARL, IARPA, NSF, AFRL, DHS) and industry (Amazon, Google, Bosch, IBM, Disney).

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Performance Mon, 23 Nov 2020 09:48:55 -0500 2021-01-18T16:00:00-05:00 2021-01-18T17:00:00-05:00 Off Campus Location Michigan Institute for Data Science Performance Heng Li
LHS Collaboratory (January 21, 2021 11:30am) https://events.umich.edu/event/80293 80293-20688136@events.umich.edu Event Begins: Thursday, January 21, 2021 11:30am
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

The LHS Collaboratory presents Rachel Richesson, PhD, MPH, MS, FACMI, Professor of Learning Health Sciences, Department of Learning Health Sciences at the University of Michigan in a virtual event on 1/21/2021 from 11:30 am to 1:00 pm ET.

Professor Richesson's talk, "Data Standards and Learning Health Systems –Challenges and Opportunities," will be followed by an audience Q&A. Questions are also encouraged prior to the event.

Please send questions to LHSCollaboratory-info@umich.edu.

Registration in advance at: https://umich-health.zoom.us/webinar/register/WN_HytRsYwITc6oOGRj0F_MOA

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Livestream / Virtual Sat, 02 Jan 2021 10:24:08 -0500 2021-01-21T11:30:00-05:00 2021-01-21T13:00:00-05:00 Off Campus Location Department of Learning Health Sciences Livestream / Virtual LHS Collaboratory logo
BME 500 Seminar - Xiaoning Jiang (January 21, 2021 4:00pm) https://events.umich.edu/event/80996 80996-20830794@events.umich.edu Event Begins: Thursday, January 21, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be held via Blue Jeans. The link will be placed below.

Blue Jeans Link: https://bluejeans.com/628109990

Xiaoning Jiang, Ph.D.

North Carolina State University

Seminar Abstract:

Cardiovascular disease (CVD) remains the number one cause of death and the search for more effective diagnosis and treatment techniques has been of a great interest. Ultrasound present a great potential in imaging and therapy for CVD. In this talk, small aperture transducers were designed, fabricated and tested for advanced intravascular ultrasound imaging (IVUS) and effective and safe intravenous sonothrombolysis. In specific, we investigated high frequency (40-60 MHz) micromachined piezoelectric composite transducers and arrays with broad bandwidth (-6 dB fraction bandwidth ~ 80%) for intravascular ultrasound (IVUS) imaging. Dual frequency transducers and arrays (6.5 MHz/30 MHz, 3 MHz/30 MHz) were also successfully demonstrated for contrast enhanced intravascular superharmonic imaging (or acoustic angiography) toward detection of plaque vulnerability. For the case of intravascular thrombolysis, small aperture (diameter <2 mm) sub-MHz forward-looking transducers were successfully developed with peak-negative-pressure of > 1.5 MPa. Significantly enhanced thrombolysis rate was observed by using microbubbles and nanodroplets in in-vitro tests. Other transducer techniques such as optical fiber laser ultrasound transducers were also investigated for intravenous sonothrombolysis. These new findings suggest that small aperture ultrasound transducers are increasingly important in advancing intravascular ultrasound imaging, intravenous therapy, minimal invasive diagnosis and therapy, and image guided drug delivery and surgery.

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Lecture / Discussion Wed, 20 Jan 2021 10:42:47 -0500 2021-01-21T16:00:00-05:00 2021-01-21T17:00:00-05:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
RNA Seminar featuring: Elena Conti, Max Planck Institute of Biochemistry (January 25, 2021 9:00am) https://events.umich.edu/event/75826 75826-19613920@events.umich.edu Event Begins: Monday, January 25, 2021 9:00am
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

KEYWORDS: molecular mechanisms, RNA, ribosome, biochemistry, cryo-EM, X-ray crystallography

ABSTRACT: All RNAs in eukaryotic cells are eventually degraded. The RNA exosome is a conserved macromolecular machine that degrades a vast number and variety of RNAs. Exosome-mediated RNA degradation leads to the complete elimination of nuclear and cytoplasmic transcripts in turnover and quality control pathways, and to the partial trimming of RNA precursors in nuclear processing pathways. How the exosome combines specificity and versatility to either eliminate or process RNAs has been a long-standing question.

ZOOM REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_IjnWw1UcRkW8zcDeuAM2tQ

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Lecture / Discussion Mon, 04 Jan 2021 10:08:44 -0500 2021-01-25T09:00:00-05:00 2021-01-25T10:00:00-05:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Elena Conti, Max Planck Institute of Biochemistry
Environmental Health Priorities in Southeast Michigan (January 26, 2021 12:00pm) https://events.umich.edu/event/80220 80220-20601996@events.umich.edu Event Begins: Tuesday, January 26, 2021 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

The Integrated Health Sciences Core (IHSC) of M-LEEaD kicks off the first in a series on community engaged research with a presentation by the Community Engagement Core (CEC) and its Stakeholder Advocacy Board (SAB). Members of the CEC and SAB will share an overview of environmental health priorities in Southeast Michigan, ongoing efforts to address them, and new opportunities for M-LEEaD affiliated researchers. This "Meet and Learn" will focus on the purpose and objective of the CEC and how these relate to the NIEHS core objectives. Please join us!

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Lecture / Discussion Tue, 22 Dec 2020 10:12:52 -0500 2021-01-26T12:00:00-05:00 2021-01-26T12:50:00-05:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Jan 26 Environmental Priorities in SE Michigan
Department of Computational Medicine & Bioinformatics Seminar (January 27, 2021 4:00pm) https://events.umich.edu/event/80722 80722-20777538@events.umich.edu Event Begins: Wednesday, January 27, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract: Massively parallel single-cell and single-nucleus RNA sequencing (sc/snRNA-seq) has opened the way to systematic tissue atlases in health and disease, but as the scale of data generation is growing, so is the need for computational pipelines for scaled analysis. We developed Cumulus, the first comprehensive cloud-based framework, to address the big data challenge arising from sc/snRNA-seq analysis. Cumulus combines the power of cloud computing with improvements in algorithm and implementation to achieve high scalability, low cost, user-friendliness and integrated support for a comprehensive set of features. We benchmark Cumulus on the Human Cell Atlas Census of Immune Cells dataset of bone marrow cells and show that it substantially improves efficiency over conventional frameworks, while maintaining or improving the quality of results, enabling large-scale studies.

In recent years, biologists have found that sc/snRNA-seq alone is not enough to reveal the full picture of how cells function and coordinate with each other in a complex tissue. They begin to couple sc/snRNA-seq with other common data modalities, such as single-cell ATAC-seq (scATAC-seq), single-cell Immune Repertoire sequencing (scIR-seq), spatial transcriptomics and mass cytometry. This data coupling is called single-cell multimodal omics. As it is becoming a new common practice, new analysis needs emerge along with two major computational challenges: big data challenge and integration challenge. The big data challenge requires us to develop scalable computational infrastructure and algorithms to deal with the ever-growing large datasets produced from the community. The integration challenge requires us to design new algorithms to enable holistic integration of heterogeneous data from different modalities. In the last part of my talk, I will discuss my team’s efforts and plans to develop Cumulus as an integrated data analysis framework for scaled single-cell multimodal omics.

Single-cell multimodal omics has the potential to provide a more comprehensive characterization of complex multicellular systems than the sum of its parts. As the datasets produced from the community keep growing substantially, the enhanced Cumulus will continue playing an important role in the effort to build atlases of complex tissues and organs at higher cellular resolution, and in leveraging them to understand the human body in health and disease.

Short bio: Dr. Bo Li is an assistant professor of medicine at Harvard Medical School, the director of Bioinformatics and Computational Biology at Center for Immunology Inflammatory Diseases, Massachusetts General Hospital, and an associate member of the Broad Institute of MIT and Harvard. His research focuses on large-scale single-cell and single-nucleus genomics data analysis. He received his Ph.D. in computer science from UW-Madison and completed two postdoctoral trainings with Dr. Lior Pachter at UC Berkeley and Dr. Aviv Regev at Broad Institute. He is best known for developing RSEM, an impactful RNA-seq transcript quantification software. RSEM is cited 9,384 times (Google Scholar) and adopted by several big consortia such as TCGA, ENCODE, GTEx and TOPMed.

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Wed, 13 Jan 2021 14:32:34 -0500 2021-01-27T16:00:00-05:00 2021-01-27T17:00:00-05:00 Off Campus Location DCMB Seminar Series Livestream / Virtual Bo Li, PhD (Assistant Professor at Harvard Medical School in Boston, MA)
Science Success Series | Growth and Grit: Developing a Mindset for Success (January 27, 2021 4:00pm) https://events.umich.edu/event/80591 80591-20759748@events.umich.edu Event Begins: Wednesday, January 27, 2021 4:00pm
Location: Off Campus Location
Organized By: Science Learning Center

What if your ability to succeed in your classes was determined in part before you even stepped into the classroom? What is the one quality you need to overcome adversity academically and in life? This workshop will detail the research of Dr. Carol Dweck and her groundbreaking work on the concept of mindset. Students will learn how to abandon a debilitating fixed mindset in favor of a growth mindset, leading to success in areas they once considered too difficult. The workshop will also introduce students to the research of Dr. Angela Duckworth, and how a growth mindset can lead to the development of grit, an essential characteristic to overcoming our fear of failure.

Register at: myumi.ch/DEDPD

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Workshop / Seminar Mon, 11 Jan 2021 11:23:23 -0500 2021-01-27T16:00:00-05:00 2021-01-27T17:30:00-05:00 Off Campus Location Science Learning Center Workshop / Seminar growth and grit
RNA Seminar featuring: Jeff Twiss, MD, PhD, SmartState Chair in Childhood Neurotherapeutics, Professor of Biological Sciences, University of South Carolina (February 1, 2021 4:00pm) https://events.umich.edu/event/75813 75813-19608028@events.umich.edu Event Begins: Monday, February 1, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_Rss4i-7WTwyf8m8ogCPXEQ

Abstract: Neurons are extremely polarized cells with axonal and dendritic processes extending 100 to 1000 fold longer or more than the cell body diameter. Our lab has been interested in how axons grow to such great distances and how they respond to injury. mRNAs are transported into axons, with their localized translation providing the axon with autonomy to respond to different stimuli by modifying their local proteome. Transport, translation, and stability of axonal mRNAs is driven by interactions with RNA binding proteins and different signaling cascades. I will focus on recent work that gives insight into how specificity of these mechanisms is driven for different cohorts of axonal mRNAs.

Keywords - Neuron, Axon, RNA transport, Translational regulation

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Lecture / Discussion Fri, 15 Jan 2021 14:13:00 -0500 2021-02-01T16:00:00-05:00 2021-02-01T17:00:00-05:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Jeff Twiss, University of South Carolina
CCMB / DCMB Weekly Seminar Series (February 3, 2021 4:00pm) https://events.umich.edu/event/81571 81571-20927558@events.umich.edu Event Begins: Wednesday, February 3, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:
Understanding intra-tumour heterogeneity (ITH), in particular identifying the presence of subclonal populations of cancer cells that may respond differently to treatments, is key to support precision medicine approaches. Capturing ITH from genomic measures raises however a number of computational challenges. In this talk I will present CloneSig, a method to infer ITH from "bulk" genomic data, in particular whole-exome sequencing data, and capture changes in mutational processes active in different subclones. I will then discuss the promises of single-cell genomics and some challenges it raises, in particular to transform raw count data into useful representations, integrate heterogeneous modalities, and learn gene regulation.

Short bio: Jean-Philippe Vert has been a research scientist at Google Brain in Paris and adjunct researcher at PSL University Mines ParisTech since 2018. He graduated from Ecole Polytechnique and holds a PhD in mathematics from Paris University. He was research professor and the founding director of the Centre for Computational Biology at Mines ParisTech from 2006 to 2018, team leader at the Curie Institute on computational biology of cancer (2008-2018), visiting scholar at UC Berkeley (2015-2016), and professor at the department of mathematics of Ecole normale supérieure in Paris (2016-2018).
His research interest concerns the development of statistical and machine learning methods, particularly to model complex, high-dimensional and structured data, with an application focus on computational biology, genomics and precision medicine. His recent contributions include new methods to embed structured data such as strings, graphs or permutations to vector spaces, regularization techniques to learn from limited amounts of data, and computationally efficient techniques for pattern detection and feature selection.
He is also working on several medical applications in cancer research, including quantifying and modeling cancer heterogeneity, predicting response to therapy, and modeling the genome and epigenome of cancer cells at the single-cell level.

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Mon, 01 Feb 2021 14:12:04 -0500 2021-02-03T16:00:00-05:00 2021-02-03T17:00:00-05:00 Off Campus Location DCMB Seminar Series Livestream / Virtual Jean-Philippe Vert, PhD (Research Scientist at Google Brain in Paris, Adjunct Researcher at PSL University Mines ParisTech)
Science Success Series | Make It Stick: Research-Based Learning Strategies You Need to Know (February 3, 2021 4:00pm) https://events.umich.edu/event/80585 80585-20759746@events.umich.edu Event Begins: Wednesday, February 3, 2021 4:00pm
Location: Off Campus Location
Organized By: Science Learning Center

The study and learning strategies students often bring to college are often insufficient to help them succeed at the university level. Particularly in challenging STEM courses, students can't simply memorize or cram their way to a good grade. This workshop will focus on the popular learning strategies to avoid, as well as the top three strategies you don't know but are shown by research to be the most effective for long-term learning.

Register at: myumi.ch/885DK

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Workshop / Seminar Mon, 11 Jan 2021 11:24:23 -0500 2021-02-03T16:00:00-05:00 2021-02-03T17:30:00-05:00 Off Campus Location Science Learning Center Workshop / Seminar make it stick
LSI Seminar Series: Blanton S. Tolbert, Ph.D., Case Western Reserve University (February 4, 2021 12:00pm) https://events.umich.edu/event/80758 80758-20783467@events.umich.edu Event Begins: Thursday, February 4, 2021 12:00pm
Location: Off Campus Location
Organized By: Life Sciences Institute (LSI)

Abstract:
RNA and related retro viruses persist to pose serious threats to human health and global economies. Disease progression mediated by viral pathogenesis requires numerous intersections between host proteins and viral RNA (vRNA) elements. Host-vRNA complexes drive essential processes in the replication cycles of viruses; as such, they represent untapped targets for therapeutic intervention. Members of the heterogeneous nuclear ribonucleoprotein (hnRNP) family are cellular proteins often usurped by RNA viruses. The Tolbert lab studies the molecular mechanisms by which RNA viruses redirect hnRNPs to control viral gene expression. In this talk, Tolbert will describe solution NMR structures of conserved viral RNA elements that regulate splicing and translation. He further will show that conformational adaptation and slow protein motions are fundamental properties by which the cellular hnRNP protein achieve cognate RNA recognition. In new and exciting results, the lab described the NMR structure of a viral RNA-small molecule complex that inhibits viral replication by attenuating viral translation and shows that the small molecule inhibitor functions through a novel allosteric mechanism to increase the affinity of an RNA- protein complex. The collective knowledge this lab is producing suggests that protein- RNA cooperativity and mutual allostery manifest as idiosyncratic mechanisms that regulate viral gene expression.

About theSpeaker:
Blanton S. Tolbert is a professor of chemistry at Case Western Reserve University, where he oversees a diverse research group that endeavors to understand biochemical mechanisms by which human pathogenic RNA viruses replicate within cells, and to leverage this knowledge to identify novel drug targets for therapeutic intervention. Tolbert is the PI of multiple NIH grants, and he has published in top journals including Nature Communications, the Proceedings of the National Academy of Sciences and the Journal of the American Chemical Society. Tolbert also serves on the NIH Office of AIDS Research Advisory Council (OARAC), and he will become the next chair of OARAC in 2021. He is a member of the Burroughs Wellcome Fund Postdoctoral Enrichment Program Advisory Board and an editor for the Journal of Biological Chemistry and Microbiology and Molecular Biology Reviews. Tolbert is the proud father of two boys, and in his spare time he enjoys exploring the outdoors in the Cleveland Metroparks.

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Workshop / Seminar Fri, 15 Jan 2021 08:14:45 -0500 2021-02-04T12:00:00-05:00 2021-02-04T13:00:00-05:00 Off Campus Location Life Sciences Institute (LSI) Workshop / Seminar LSI Seminar Series
BME 500 Seminar: Maria Coronel (February 4, 2021 4:00pm) https://events.umich.edu/event/81382 81382-20889813@events.umich.edu Event Begins: Thursday, February 4, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

BME Faculty Candidate
Maria Coronel, Ph.D.
Georgia Institute of Technology

Seminar Abstract:
Two major challenges to the translation of cellular-based tissue-engineered therapies are the lack of adequate oxygen support post-implantation and the need for systemic immunosuppression to halt the strong inflammatory and immunological response of the host. As such, strategies that aim at addressing oxygen demand, and local immunological responses can be highly beneficial in the translation of these therapies. In this seminar, I will focus on two biomaterial strategies to create a more favorable transplant niche for pancreatic islet transplantation. The first half will describe an in-situ oxygen-releasing biomaterial fabricated through the incorporation of solid peroxides in a silicone polymer. The implementation of this localized, controlled and sustained oxygen-generator mitigates the activation of detrimental hypoxia-induced pathways in islets and enhances the potency of extrahepatic 3D islet- loaded devices in a diabetic animal model. In the second part, I will focus on engineering synthetic biomaterials for the delivery of immunomodulatory signals for transplant acceptance. Biomaterial carriers fabricated with polyethylene glycol microgels are used to deliver immunomodulatory signals to regulate the local microenvironment and prevent allograft rejection in a clinically relevant pre-clinical transplant model. The use of synthetic materials as an off-the-shelf platform, without the need for manipulating the biological cell product, improves the clinical translatability of this engineered approach. Designing safer, responsive biomaterials to boost the delivery of targeted therapeutics will significantly reinvigorate interventional cell-based tissue-engineered therapies.

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Lecture / Discussion Fri, 29 Jan 2021 17:14:27 -0500 2021-02-04T16:00:00-05:00 2021-02-04T17:00:00-05:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Community Action to Promote Healthy Environments: Research to Improve Air Quality & Health in Detroit (February 9, 2021 12:00pm) https://events.umich.edu/event/81709 81709-20943461@events.umich.edu Event Begins: Tuesday, February 9, 2021 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

With Amy Schulz (HBHE UM SPH), Stuart Batterman (EHS UM SPH), and Angela Reyes (Detroit Hispanic Development Corporation) speaking on "Community Action to Promote Healthy Environments: Research to Improve Air Quality & Health in Detroit".

ZOOM LINK: HTTPS://UMICH.ZOOM.US/J/96155698295

Organized by the Community Engagement Core & Integrated Health Sciences Core of M-LEEaD (Michigan Center on Lifestage Environmental Exposures and Disease)

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Livestream / Virtual Wed, 03 Feb 2021 16:27:30 -0500 2021-02-09T12:00:00-05:00 2021-02-09T12:50:00-05:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Livestream / Virtual Feb 9 Air Quality & Health in Detroit
CCMB / DCMB Weekly Seminar (February 10, 2021 4:00pm) https://events.umich.edu/event/81413 81413-20893777@events.umich.edu Event Begins: Wednesday, February 10, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract: The increasing omics data and advanced AI technology present a great opportunity for novel biomarker-driven cancer therapies. My talk will cover two parts. First, I will introduce DrBioRight, a natural language-oriented and AI-driven analytic platform for omic data analysis. This platform allows users to perform analysis directly through human languages and it improves the performance through adaptive learning. Armed with NLP and AI technologies, this analytic will maximize the utility of omics data and lead to a new paradigm for biomedical research. Second, I will discuss our recent work on enhancer RNAs. We show that the eRNAs provide explanatory power for cancer phenotypes beyond that provided by mRNA expression through resolving intratumoral heterogeneity with enhancer cell-type specificity. Our study provides a high-resolution map of eRNA loci through which enhancer activities can be quantified by RNA-seq, enabling a broad range of biomedical investigations.

Bio: Dr. Liang is a Barnhart Family Distinguished Professor in Targeted Therapies and the Deputy Chair of Department of Bioinformatics and Computational Biology at the University of Texas MD Anderson Cancer Center. He is also a professor in the Department of Systems Biology. He received his B.S. in chemistry from Peking University (China) in 2001 and Ph.D. in quantitative and computational biology from Princeton University (NJ, USA) in 2006. Dr. Liang then finished his postdoctoral training in evolutionary and computational genomics at the University of Chicago. He joined MD Anderson Cancer Center as Assistant Professor and started his own group in 2009.
At MD Anderson, Dr. Liang’s group focuses on bioinformatics tool development, integrated cancer genomic analysis, regulatory RNA regulation/modification, and cancer systems biology. His systematic studies on enhancer regulation, RNA editing, functional proteomics, sex effects, and driver mutations in cancer have generated profound impacts on the biomedical research community and attracted wide attention such as The Wall Street Journal and Newsweek. The bioinformatics tools his group developed (such as TCPA, TANRIC, FASMIC, DrBioRight) collectively have >110,000 active users worldwide. Since 2010, he has published >140 papers total citation >25,000 times), including 41 corresponding-author papers in top journals such as Cell, Cancer Cell, Nature Genetics, Nature Biotechnology, and Nature Methods.
Dr. Liang has taken leadership roles in large cancer consortium projects, including chair of The Cancer Genome Atlas (TCGA) PanCanAtlas working groups, one co-leader of International Cancer Genome Consortium (ICGC) Pan-Cancer Whole Genome Analysis Project, and one co-chair of NCI Genomic Data Commons (GDC) QC working group. He won several awards including MD Anderson R. Lee Clark Fellow Award (2014), the University of Texas System STARS Award (2015), MD Anderson Faculty Scholar Award (2018), and AACR Team Science Award (2020). He is an elected Fellow of American Association for the Advancement of Science (AAAS).

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Thu, 28 Jan 2021 11:33:05 -0500 2021-02-10T16:00:00-05:00 2021-02-10T17:00:00-05:00 Off Campus Location DCMB Seminar Series Livestream / Virtual Han Liang, PhD Professor and Deputy Chair, Department of Bioinformatics and Computational Biology Professor, Department of Systems Biology Barnhart Family Distinguished Professor in Targeted Therapies The University of Texas MD Anderson Cancer Center
Oral Health Sciences Seminar Series (February 11, 2021 12:00pm) https://events.umich.edu/event/81688 81688-20943436@events.umich.edu Event Begins: Thursday, February 11, 2021 12:00pm
Location: Off Campus Location
Organized By: Office of Research School of Dentistry

Lola Eniola-Adefeso, Ph.D.
University Diversity and Social Transformation Professor of Chemical Engineering
Vice-Chair for Graduate Studies in Chemical Engineering
Professor of Biomedical Engineering
Professor of Macromolecular Science and Engineering
Miller Faculty Scholar
Director, Cell Adhesion and Drug Delivery Lab
Associate Director, NIH Cellular Biotechnology Training Grant
University of Michigan

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Presentation Mon, 31 Jan 2022 10:25:38 -0500 2021-02-11T12:00:00-05:00 2021-02-11T13:00:00-05:00 Off Campus Location Office of Research School of Dentistry Presentation Lola Eniola-Adefeso, Ph.D.
BME 500 Seminar: Gloria Kim (February 11, 2021 4:00pm) https://events.umich.edu/event/81383 81383-20889814@events.umich.edu Event Begins: Thursday, February 11, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Seminar Abstract:

The major problems in the current therapy for oncologic diseases include its inability to selectively target specific tumor cells in the surrounding tissues that make it hard for the drugs and treatment to reach the tumor cells. Despite the significant progress in the discovery of surface markers, targeting ligands, and biomaterial carriers, very few nanoparticle drugs are truly tumor-specific after intravenous injection and their targeting is still not fully reliable, which results in a wide distribution of nanoparticles throughout the body and increases the chance of adverse side effects. To overcome such limitations, my graduate research implemented immune cells as living targeting and delivery vehicles that deliver therapeutic biodegradable photoluminescent polymer (BPLP)-based nanoparticles to two tumor models, melanoma and glioblastoma. This system takes advantage of the inherent targeting and penetrating capabilities of immune cells into the tumor target and the fluorescent properties of BPLP nanoparticles for in vivo imaging. Our platform technology allows assembling various types of nanoparticles, drugs, imaging agents, and immune cells as a treatment for different diseases in the future. The second part of the seminar introduces how the immune cells can also be genetically engineered for cancer immunotherapy in vivo. Even with huge success in the development of CD19-targeting chimeric antigen receptor (CAR) T cells for B-cell hematological malignancies, we still face major challenges in expanding adoptive cell transfer for solid tumors. To expand this adoptive cell therapy, finding the right targets for solid tumors that are tumor- and tumor microenvironment-specific is the foremost important step. During my postdoctoral work, we have found an epitope within the collagen alpha-3(VI) (COL6A3) gene, which can be used as a biomarker to target stromal cells associated with multiple solid tumors. COL6A3-specific TCRs were isolated and one of these TCRs was affinity enhanced so that the T cells expressing TCR variants that preserved COL6A3 specificity and endowed both CD4 and CD8 T cells with augmented effector functions were able to specifically eliminate tumors in vivo that expressed similar amount of peptide-human leukocyte antigen (pHLA) as primary tumor specimens with favorable safety profile with no detectable off-target reactivity. These preclinical findings serve as the basis and rationale to initiate clinical trials using COL6A3-specific TCRs to target an array of solid tumors. As a principal investigator, my lab will first focus on merging immunology, synthetic biology, genetic engineering, material science, and biomedical engineering to develop and evaluate the next generation T cell-based therapies that target and kill solid tumors with enhanced specificity, reduced toxicity, and the ability to overcome tumor-associated immunosuppression.

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Lecture / Discussion Fri, 05 Feb 2021 16:15:40 -0500 2021-02-11T16:00:00-05:00 2021-02-11T17:00:00-05:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Innovations in Relating Real Life Exposures to Chemicals and Chemical Mixtures to Health Outcomes (February 12, 2021 1:00pm) https://events.umich.edu/event/79684 79684-20454248@events.umich.edu Event Begins: Friday, February 12, 2021 1:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Tentative Symposium Schedule

1:00-1:05 - Introduction
1:05-1:30 - Dr. Andreas Kortenkamp, Brunel University: “Male reproductive health – a bad cocktail of endocrine disruptors”
1:30-1:55 - Dr. Jodi Flaws, University of Illinois at Urbana-Champaign: “Applying real life phthalate mixtures from an Illinois pregnancy cohort to toxicological models”
1:55-2:20 - Dr. Laura Vandenberg, University of Massachusetts Amherst: “The mammary gland is a sensitive organ: lessons learned from fracking chemical mixtures”
2:00-2:55 - Dr. Paul Fowler, University of Aberdeen: “Exposure to the complex mixture of environmental chemicals found in human biosolids”
2:55-3:20 - Dr. Jyotsna Jagai, University of Illinois at Chicago: “Cumulative environmental quality and diabetes rates and control”
3:20-3.35 - Questions
3:35-4:00 - Panel Discussion, featuring: Dr. Jennifer McPartland, Environmental Defense Fund, Dr. Natalie Sampson, University of Michigan, Dr. Zorimar Rivera-Núñez, Rutgers University

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Workshop / Seminar Mon, 11 Jan 2021 09:15:50 -0500 2021-02-12T13:00:00-05:00 2021-02-12T16:00:00-05:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Workshop / Seminar FLYER_20210212_Symposium
RNA Seminar featuring: Karla Neugebauer, Yale University School of Medicine (February 15, 2021 4:00pm) https://events.umich.edu/event/78295 78295-20004839@events.umich.edu Event Begins: Monday, February 15, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

ZOOM REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_aZggyZ0yQcSPcJrsHloXjQ

ABSTRACT: My lab is interested in the coordination between transcription, RNA processing and nuclear organization that governs gene expression. We have established experimental systems in budding yeast, zebrafish embryos, and mammalian tissue culture cells to explore transcription and splicing regulation in a variety of biological contexts and with a diversity of tools, from imaging to genome-wide approaches. Our observations have provided novel insights into transcription and splicing mechanisms as well as principles of cellular organization that facilitate efficient gene expression. In this talk, I will be discussing rapid co-transcriptional splicing during erythropoiesis and how Cajal bodies assemble to ensure a steady supply of spliceosomal components.

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Lecture / Discussion Tue, 02 Feb 2021 16:32:41 -0500 2021-02-15T16:00:00-05:00 2021-02-15T17:00:00-05:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Prof. Karla Neugebauer, Ph.D.
Microbiome Seminar: A microbial metabolite remodels the gut-liver axis following bariatric surgery (February 17, 2021 9:00am) https://events.umich.edu/event/82101 82101-21036675@events.umich.edu Event Begins: Wednesday, February 17, 2021 9:00am
Location: Off Campus Location
Organized By: Michigan Microbiome Project

Speaker Affiliation:
Department of Biological Chemistry and Molecular Pharmacology
Harvard Medical School

Hosted By:
Matthew Ostrowski, PhD
Thomas Schmidt, PhD
Michigan Microbiome Project

Abstract: Bariatric surgery is the most effective treatment for obesity and obesity-related type 2 diabetes. As a result of its minimal side-effect profile, sleeve gastrectomy (SG) is currently the safest and most commonly performed bariatric surgery in the United States. Moreover, this procedure is associated with changes in gut metabolites. In previous work, we discovered that the host-produced compound cholic acid-7-sulfate (CA7S) is a gut-restricted TGR5 agonist with anti-diabetic properties and that this metabolite is elevated following SG. In new studies, we have elucidated a microbiome-dependent pathway by which SG increases CA7S production. We found that a microbial metabolite, lithocholic acid (LCA), is increased in murine portal veins post-SG and by activating the vitamin D receptor, induces hepatic sulfotransferase expression to drive CA7S production. An SG-induced shift in the microbiome increases expression of the bile acid transporters Asbt and Ostα in the distal ileum, a change that in turn facilitates selective transport of LCA across the gut epithelium. Cecal microbiota transplant from SG animals is sufficient to recreate the pathway in germ-free (GF) animals. Activation of this gut-liver pathway leads to CA7S synthesis and GLP-1 secretion, for the first time causally connecting a microbial metabolite with the improvement of diabetic phenotypes following bariatric surgery. This study provides evidence that the microbiome, and specifically, the microbial metabolite LCA, affects host metabolism, illustrating the importance of studying metabolite transport and signaling in the enterohepatic axis.

Zoom Meeting: https://umich.zoom.us/j/99830183560

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Workshop / Seminar Mon, 15 Feb 2021 12:11:18 -0500 2021-02-17T09:00:00-05:00 2021-02-17T10:00:00-05:00 Off Campus Location Michigan Microbiome Project Workshop / Seminar MMP logo
Improving the Evidence to Practice Gap through Innovation in Health Science Education (February 17, 2021 3:00pm) https://events.umich.edu/event/81403 81403-20893762@events.umich.edu Event Begins: Wednesday, February 17, 2021 3:00pm
Location: Off Campus Location
Organized By: RISE (Research. Innovation. Scholarship. Education.)

Please join us on Wednesday, February 17, 2021, 3:00 - 4:00 PM for a discussion on Improving the Evidence to Practice Gap through Innovation in Health Science Education.

Register for the event via Eventbrite: https://www.eventbrite.com/e/rise-virtual-talking-circle-tickets-130006826919

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Workshop / Seminar Thu, 28 Jan 2021 06:37:46 -0500 2021-02-17T15:00:00-05:00 2021-02-17T16:00:00-05:00 Off Campus Location RISE (Research. Innovation. Scholarship. Education.) Workshop / Seminar RISE Virtual Talking Circle
Special Joint Seminar between our Department and the Genome Science Training Program (February 17, 2021 4:00pm) https://events.umich.edu/event/80415 80415-20719669@events.umich.edu Event Begins: Wednesday, February 17, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract: The human genome sequence folds in three dimensions (3D) into a rich variety of locus-specific contact patterns. Despite growing appreciation for the importance of 3D genome folding in evolution and disease, we lack models for relating mutations in genome sequences to changes in genome structure and function. Towards that goal, we discovered that the organization of gene regulatory domains within chromosomes and the specific sequences that sit at boundaries between domains are under strong negative selection in the human population and over primate evolution. Motivated by this signature of functional importance, we developed a deep convolutional neural network, called Akita, that accurately predicts genome folding from DNA sequence alone. Representations learned by Akita underscore the importance of the structural protein CTCF but also reveal a complex grammar beyond CTCF binding sites that underlies genome folding. Akita enabled rapid in silico predictions for effects of sequence mutagenesis on the 3D genome, including differences in genome folding across species and in disease cohorts, which we are validating with CRISPR-edited genomes. This prediction-first strategy exemplifies my vision for a more proactive, rather than reactive, role for data science in biomedical research.

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

Short bio: Dr. Katherine S. Pollard is Director of the Gladstone Institute of Data Science & Biotechnology, Investigator at the Chan Zuckerberg Biohub, Professor in the Department of Epidemiology & Biostatistics and Bioinformatics Graduate Program at UCSF. Her lab develops statistical models and open source bioinformatics software for the analysis of massive genomic datasets. Previously, Dr. Pollard was an assistant professor in the University of California, Davis Genome Center and Department of Statistics. She earned her PhD in Biostatistics from the University of California, Berkeley and was a comparative genomics postdoctoral fellow at the University of California, Santa Cruz. She was awarded the Thomas J. Watson Fellowship, the Sloan Research Fellowship, and the Alumna of the Year from UC Berkeley. She is a Fellow of the International Society for Computational Biology and of the California Academy of Sciences.

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Livestream / Virtual Wed, 06 Jan 2021 09:24:05 -0500 2021-02-17T16:00:00-05:00 2021-02-17T17:00:00-05:00 Off Campus Location DCMB Seminar Series Livestream / Virtual Katherine S. Pollard, PhD (Director, Gladstone Institute of Data Science & Biotechnology; Professor, UCSF; Investigator, Chan Zuckerberg Biohub)
Powering through Uncertainty (February 18, 2021 1:00pm) https://events.umich.edu/event/80885 80885-20816994@events.umich.edu Event Begins: Thursday, February 18, 2021 1:00pm
Location: Off Campus Location
Organized By: Office of Research School of Dentistry

Platform Architect, Intel & Founder, Timouns

Dr. Simon is a biomedical engineer, author and inventor who graduated from the University of Michigan Biomedical Engineering PhD program and was a School of Dentistry T32-TEAM Training Grant trainee. Her keynote seminar titled "Powering through Uncertainty" will encourage and inspire our students, faculty and staff as we strive to meet our mission of advancing health through education, service, research and discovery.

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Livestream / Virtual Mon, 18 Jan 2021 14:05:48 -0500 2021-02-18T13:00:00-05:00 2021-02-18T14:00:00-05:00 Off Campus Location Office of Research School of Dentistry Livestream / Virtual Keynote Speaker, Arlyne Simon
BME 500 Seminar: Adam Glaser (February 18, 2021 4:00pm) https://events.umich.edu/event/81384 81384-20889815@events.umich.edu Event Begins: Thursday, February 18, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Seminar Abstract:

New developments in microscopy, tissue clearing, and fluorescent labeling are enabling unprecedented access to the structural and molecular contents of biological tissues. These technologies are now opening new doors in scientific research and shedding light on the critical factors which underpin complex disease processes. In this presentation, I will present my recent work in these areas, with a focus on applications to cancer at both the clinical and preclinical level.

ZOOM LINK: https://umich.zoom.us/j/94405051853

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Lecture / Discussion Sat, 13 Feb 2021 20:04:17 -0500 2021-02-18T16:00:00-05:00 2021-02-18T17:00:00-05:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Science Success Series | Medical School Student Panel Discussion (February 18, 2021 6:30pm) https://events.umich.edu/event/80634 80634-20769609@events.umich.edu Event Begins: Thursday, February 18, 2021 6:30pm
Location: Off Campus Location
Organized By: Science Learning Center

Here is your chance to hear about what life is like for several medical school students and residents. Learn about each of their paths to medicine, experiences in various medical schools, and things they wished they had known in college.

Panelists:

Jasmine D.Johnson, M.D., FACOG/Clinical Instructor & Fellow UNC Department of Obstetrics & Gynecology/ Division of Maternal-Fetal Medicine

Eric Poole. Rising M3, Michigan State University College of Human Medicine

Register at: myumi.ch/Wwm09

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Workshop / Seminar Tue, 12 Jan 2021 12:14:31 -0500 2021-02-18T18:30:00-05:00 2021-02-18T19:30:00-05:00 Off Campus Location Science Learning Center Workshop / Seminar book and stethoscope
Science Success Series | Ace Your Courses: Metacognition is Key! (February 22, 2021 4:00pm) https://events.umich.edu/event/80592 80592-20759749@events.umich.edu Event Begins: Monday, February 22, 2021 4:00pm
Location: Off Campus Location
Organized By: Science Learning Center

Have you ever found yourself putting forth a great deal of effort into your courses, but not feeling like you are actually learning or are left unsatisfied with your grade? This workshop, based on the work of Dr. Saundra Yancy McGuire, will enable you to analyze your current learning strategies, understand exactly what changes you need to implement to earn an A in your courses, identify concrete strategies to use during the remainder of your semester, and become a more efficient learner.

Register at: myumi.ch/9o7zb

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Workshop / Seminar Mon, 11 Jan 2021 11:32:51 -0500 2021-02-22T16:00:00-05:00 2021-02-22T17:30:00-05:00 Off Campus Location Science Learning Center Workshop / Seminar Teach Yourself How to Learn
LHS Collaboratory- February session (February 23, 2021 12:00pm) https://events.umich.edu/event/81035 81035-20838675@events.umich.edu Event Begins: Tuesday, February 23, 2021 12:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

The keynote presentation (12:00 pm-1:15 pm ET) will be followed by breakout sessions (1:15 pm-2:15 pm ET) on topics presented by the UM faculty and guests.
Zoom links to the individual breakout sessions are listed below.

Keynote speaker: Dr. Bernardo Mariano, Jr.
Topic: Digital Transformation in Healthcare for a Diverse World
Director of Digital Health & Innovation
Chief Information Officer (CIO)
World Health Organization (WHO)

Remarks:
Laurie McCauley, DDS, MS, PhD
Dean, William K and Mary Anne Najjar Professor of Periodontics
University of Michigan School of Dentistry


Breakout sessions from 1:15 pm-2:15 pm (ET)

Breakout Session #1 LHS and Pain
Zoom link: https://umich.zoom.us/j/99190944947

Topic: Integrating Diverse Health Ecosystems for
Optimal Pain Treatment, Education and Research
Alex F. DaSilva, DDS, DMedSc
University of Michigan School of Dentistry

Perspective: Data De‐Identification and Clinical Decision Support
Ivo Dinov, Ph.D.
Department of Health Behavior and Biological Sciences
University of Michigan


Breakout Session #2 LHS and Caries Risk
Zoom link: https://umich.zoom.us/j/97070468943

Topic: Caries Risk Prediction Models
Margherita Fontana, DDS, PhD
University of Michigan School of Dentistry

Perspective: LHS and Evidence-based Clinical Practice
Alonso Carrasco-Labra, DDS, MSc, PhD
Department of Evidence Synthesis and Translation Research
American Dental Association

Breakout Session #3 LHS and Opioids
Zoom link: https://umich.zoom.us/j/96029888703


Topic: Iteratively Learning about Dental Opioid Prescribing
Romesh Nalliah, BDS, MHCM
University of Michigan School of Dentistry

Perspective: Precision Health in Opioid Management
Chad Brummett, M.D.
University of Michigan Department of Anesthesiology

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Lecture / Discussion Thu, 21 Jan 2021 09:43:32 -0500 2021-02-23T12:00:00-05:00 2021-02-23T14:15:00-05:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion LHS Collaboratory Logo
Bioethics Discussion: Artificial Life (February 23, 2021 7:00pm) https://events.umich.edu/event/58837 58837-14563729@events.umich.edu Event Begins: Tuesday, February 23, 2021 7:00pm
Location: Off Campus Location
Organized By: The Bioethics Discussion Group

A discussion on new forms.

Join us at: https://umich.zoom.us/j/99926126455.

A few readings to consider:
––Is the creation of artificial life morally significant?
––Why Do We Need Artificial Life?
––Artificial Life
––The Bioethicist Who Cried “Synthetic Biology”: An Analysis of the Function of Bioterrorism Predictions in Bioethics

For more information and/or to receive a copy of the readings visit http://belmont.bme.umich.edu/bioethics-discussion-group/discussions/056-artificial-life/.

––
Life finds a way over to the blog: https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Fri, 08 Jan 2021 09:41:49 -0500 2021-02-23T19:00:00-05:00 2021-02-23T20:30:00-05:00 Off Campus Location The Bioethics Discussion Group Lecture / Discussion Artificial Life
Toxic Equilibrium: Structural Racism and Population Health Inequities (February 24, 2021 10:00am) https://events.umich.edu/event/81748 81748-20949404@events.umich.edu Event Begins: Wednesday, February 24, 2021 10:00am
Location: Off Campus Location
Organized By: Institute for Social Research

February 24, 2021
10:00am – 6:30pm
Eastern Time

The American social structure is composed of a resilient, symbiotic network of the formal and informal institutions that operate to maintain an equilibrium toward White privilege. Across time and place, changes in one institution can reverberate through other institutions, and importantly, when we attempt to intervene toward equity in one institution, other institutions can move to restore this toxic equilibrium. Cultural racism, which encompasses the socially accepted ideologies, values, and behavioral norms determined by the dominant power group, sets this equilibrium. Particularly insidious as it operates on the level of our shared social subconscious, the processes that comprise cultural racism are invisible to many because they are our “givens”, our assumptions, our defaults – but the result shapes our answers to the question: Whose life counts?

For our 6th annual University of Michigan RacismLab Symposium on the Study of Racism, we pay tribute to the legacy of Dr. James Jackson, whose mentorship guided our 1st annual symposium in 2015 and resulted in our guest edited Social Science and Medicine special issue on cultural and structural racism. In the introduction to this special issue, we called for all scholarship on race and health to be grounded in interdisciplinary frameworks of cultural and structural racism and critical race theory.

Our annual symposium continues to be sponsored by the University of Michigan Survey Research Center at the Institute for Social Research. For our virtual meeting in 2021, we partner with the Interdisciplinary Association for Population Health Science (IAPHS) to move our discussions to a national stage. As we move to a national, interdisciplinary discussion, we are honored that a pioneer in the study of structural racism, Dr. Eduardo Bonilla Silva will serve as the keynote speaker this year.

Please register for this event: https://iaphs.org/tools-for-success/online-events/racismlab/racismlab-registration/

Event link will be provided upon registration.

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Conference / Symposium Wed, 17 Feb 2021 15:24:54 -0500 2021-02-24T10:00:00-05:00 2021-02-24T18:30:00-05:00 Off Campus Location Institute for Social Research Conference / Symposium poster
CCMB / DCMB Weekly Seminar (February 24, 2021 4:00pm) https://events.umich.edu/event/82197 82197-21052530@events.umich.edu Event Begins: Wednesday, February 24, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract: COVID Moonshot is an international consortium aiming to discover patent-free oral antiviral against SARS-CoV-2, targeting the main protease. Operating under an open science ethos, we make all data and structures publicly available, and crowdsource molecule designs from the community. In less than a year, we went from fragment hits to nanomolar leads in biochemical and antiviral assays. In my talk, I will discuss Moonshot’s journey towards orally bioavailable, non-covalent, and non-peptidomimetic Mpro inhibitors. I will discuss how machine learning technologies have accelerated our design-make-test cycle, and the learnings we gleaned from this large-scale prospective use of algorithms.

Bio: Dr. Alpha Lee is a Group Leader in the Department of Physics, University of Cambridge. His research focuses on developing machine learning technologies that close the design-make-test cycle for small molecule drug discovery and materials discovery. He is interested in how physical and chemical insights can be integrated into the design of interpretable algorithms. Before joining Cambridge, Dr. Lee was a Fulbright Scholar at Harvard and obtained his PhD from the University of Oxford.

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Wed, 17 Feb 2021 13:18:31 -0500 2021-02-24T16:00:00-05:00 2021-02-24T17:00:00-05:00 Off Campus Location DCMB Seminar Series Livestream / Virtual
BME 500 Seminar: Jorge Marchand (February 25, 2021 4:00pm) https://events.umich.edu/event/81385 81385-20889816@events.umich.edu Event Begins: Thursday, February 25, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Seminar Abstract:

In living organisms, translation of genetic information by the ribosome transforms
the information embedded in DNA into actuating components, namely proteins. Though life itself is incredibly diverse at the macroscopic level, at the molecular level, all of life uses the same set of machinery for translation - 20 standard amino acid building blocks (with minor exceptions), transfer RNAs (tRNA), and ribosomes. The convergence and association of these interdependent biomolecules is neatly captured in a table known as the ‘standard genetic code’. Even after billions of years of genetic drift, the ‘standard genetic code’ has been largely refractory to change. In this talk, I will be discussing strategies and methods for building organisms that can make and use non-standard amino acids to make proteins with enhanced or expanded function.

ZOOM LINK: https://umich.zoom.us/j/94405051853

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Lecture / Discussion Sun, 21 Feb 2021 22:07:28 -0500 2021-02-25T16:00:00-05:00 2021-02-25T17:00:00-05:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Microbiome Seminar: Assessing the role of microbial metabolites in enhancing iron-mediated cell toxicity in colon cancer (March 3, 2021 9:00am) https://events.umich.edu/event/82453 82453-21100207@events.umich.edu Event Begins: Wednesday, March 3, 2021 9:00am
Location: Off Campus Location
Organized By: Michigan Microbiome Project

Yatrik Shah lab, Molecular and Integrative Physiology

Host: Matthew Ostrowski, PhD, Microbiology and Immunology

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Workshop / Seminar Tue, 23 Feb 2021 16:26:13 -0500 2021-03-03T09:00:00-05:00 2021-03-03T10:00:00-05:00 Off Campus Location Michigan Microbiome Project Workshop / Seminar MMP
RNA Seminar featuring: Melissa Moore, Moderna Therapeutics (March 3, 2021 4:00pm) https://events.umich.edu/event/81265 81265-20879904@events.umich.edu Event Begins: Wednesday, March 3, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

**Please register here for March 3rd seminar: https://umich.zoom.us/webinar/register/WN_l0kt_NjpRh-f33LJj7KGpA

Dr. Moore will address scientists and non-scientists, and will take live questions.

In her role as Chief Scientific Officer, Platform Research, Dr. Melissa Moore is responsible for leading mRNA biology, delivery and computation science research at Moderna. She joined Moderna in 2016 from the University of Massachusetts Medical School, where she served as Professor of Biochemistry & Molecular Pharmacology, Eleanor Eustis Farrington Chair in Cancer Research and a long-time Investigator at the Howard Hughes Medical Institute (HHMI). Dr. Moore was also a founding Co-Director of the RNA Therapeutics Institute (RTI) at UMassMed, and was instrumental in creating the Massachusetts Therapeutic and Entrepreneurship Realization initiative (MassTERi), a faculty-led program intended to facilitate the translation of UMMS discoveries into drugs, products, technologies and companies. Dr. Moore is an elected member of the National Academy of Sciences (2017) and a Fellow of the American Academy of Arts and Sciences (2019).

Dr. Moore holds a B.S. in Chemistry and Biology from the College of William and Mary, and a Ph.D. in Biological Chemistry from MIT, where she specialized in enzymology under Prof. Christopher T. Walsh. She began working on RNA metabolism during her postdoctoral training with Phillip A. Sharp at MIT. During her 23 years as a faculty member, first at Brandeis and then at UMassMed, her research encompassed a broad array of topics related to the roles of RNA and RNA-protein (RNP) complexes in gene expression, and touched on many human diseases including cancer, neurodegeneration, and preeclampsia.

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Lecture / Discussion Wed, 10 Feb 2021 19:47:49 -0500 2021-03-03T16:00:00-05:00 2021-03-03T17:00:00-05:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Melissa Moore, Ph.D., Moderna Therapeutics
BME 500 Seminar: Danielle Bassett (March 4, 2021 4:00pm) https://events.umich.edu/event/81388 81388-20889818@events.umich.edu Event Begins: Thursday, March 4, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

TBD

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Lecture / Discussion Wed, 27 Jan 2021 21:05:02 -0500 2021-03-04T16:00:00-05:00 2021-03-04T17:00:00-05:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
BME 500 Seminar: Sasha Cai Lesher-Perez (March 4, 2021 4:00pm) https://events.umich.edu/event/81387 81387-20889817@events.umich.edu Event Begins: Thursday, March 4, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Efforts to close the gap between in vitro to in vivo model systems have produced technologies that more effectively evaluate spatial, structural, and mechanical control mechanisms. However, existing in vitro models lack temporal regulation that captures the controlled, rhythmic processes that often occur in biological phenomena. A major contributor to this tech-bio mismatch is the difficulty to easily and sustainably scale our ability to apply timed oscillations, representative of biorhythms, in vitro. Developing technologies that are simpler and more adoptable for users, while ensuring higher throughput, have the potential to shift the way in which we establish cell cultures with a dynamic biorhythmic baseline.

In this talk, I will cover how my previous work in different technology platforms will be leveraged to establish next generation cell and tissue culture platforms that enable biomolecule timed oscillations in more complex microenvironments. First, I will discuss the development of microfluidic self-regulating circuits as a tool to produce modular chemical profiles on-chip at different timescales. Second, I will describe microparticle building blocks for the generation of customizable porous scaffolds that are porous, and consequently perfusable, enabling our ability to apply biomolecule timed oscillations through liquid flow to 3D scaffolds. Finally, I will describe my proposed research on establishing biorhythms in vitro and how these in vitro model systems will enable my research group to begin studying how stress within our lives lead to specific disease priming mechanisms.

ZOOM LINK: https://umich.zoom.us/j/94405051853

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Lecture / Discussion Fri, 26 Feb 2021 16:50:20 -0500 2021-03-04T16:00:00-05:00 2021-03-04T17:00:00-05:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Energy Equity: Health Impact Assessment of Detroit Energy's Integrated Resource Plan (March 9, 2021 12:00pm) https://events.umich.edu/event/82482 82482-21108102@events.umich.edu Event Begins: Tuesday, March 9, 2021 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Speakers include Michelle Martinez from the Michigan Environmental Justice Coalition; Carina Gronlund from the Social Environment and Health Program, Survey Research Center, UM Institute for Social Research; and Tony Reames from UM's School for Environment & Sustainability.

Webinar Series co-sponsored by Departments of Environmental Health Sciences, & Health Behavior, Health Education DEI committees.

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Lecture / Discussion Wed, 24 Feb 2021 15:55:49 -0500 2021-03-09T12:00:00-05:00 2021-03-09T12:50:00-05:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Energy Equity (Detroit) March 9 Webinar
Bioethics Discussion: Infection (March 9, 2021 7:00pm) https://events.umich.edu/event/58838 58838-14563730@events.umich.edu Event Begins: Tuesday, March 9, 2021 7:00pm
Location: Off Campus Location
Organized By: The Bioethics Discussion Group

A discussion spreading to others.

Join us at: https://umich.zoom.us/j/99926126455.

A few readings to consider:
––Evidence and Effectiveness in Decision-Making for Quarantine
––The 1918 Influenza Pandemic: Insights for the 21st Century
––From SARS to Ebola: Legal and Ethical Considerations for Modern Quarantine
––Responding to the COVID-19 pandemic: Ethical considerations for conducting controlled human infection studies

For more information and/or to receive a copy of the readings visit http://belmont.bme.umich.edu/bioethics-discussion-group/discussions/057-infection/.

––
Feel free to stop by the website, not even the blog is viral: https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Fri, 08 Jan 2021 09:40:23 -0500 2021-03-09T19:00:00-05:00 2021-03-09T20:30:00-05:00 Off Campus Location The Bioethics Discussion Group Lecture / Discussion Infection
CCMB / DCMB Weekly Seminar Series (March 10, 2021 4:00pm) https://events.umich.edu/event/82479 82479-21108092@events.umich.edu Event Begins: Wednesday, March 10, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract: Single-cell technologies have transformed biomedical research in the last few years. With single-cell sequencing, we can now simultaneously measure thousands of genomics features in a large number of cells, which provides an ultrahigh resolution phenotypic map for each individual. However, single-cell protocols are complex. Even with the most sensitive platforms, the data are often sparse and noisy. Recent development of single-cell multi-omics and spatial transcriptomics technologies further imposed additional challenges on data integration. In this talk, I will present several machine learning methods that my group recently developed for single-cell and spatial transcriptomics data analysis. I will discuss methods for simultaneous denoising, clustering and batch effect correction, single-cell multi-omics data integration, identification of spatially variable genes, generation of super-resolution gene expression, and inference of cell type distribution in spatial transcriptomics. I will illustrate our methods by showing results from ongoing collaborations on cardiometabolic disease and applications to brain and cancer data.
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Biography: Dr. Li’s research interests include statistical genetics and genomics, bioinformatics, and computational biology. The central theme of her current research is to use statistical and computational approaches to understand cellular heterogeneity in human-disease-relevant tissues, to characterize gene expression diversity across cell types, to study the patterns of cell state transition and crosstalk of various cells using data generated from single-cell and spatial transcriptomics studies, and to translate these findings to the clinics. In addition to methods development, Dr. Li is also interested in collaborating with researchers seeking to identify complex disease susceptibility genes and acting cell types. She is Director of Biostatistics for the Gene Therapy Program at Penn, where she advises biostatistics and bioinformatics analysis for various gene therapy studies. She is also Chair of the Graduate Program in Biostatistics. Dr. Li actively serves in the scientific community. She served as a regular member for the NIH Genomics, Computational Biology and Technology (GCAT) study section for 6 years, and the NHGRI Center for Inherited Disease Research (CIDR) for 3 years. She is an Associate Editor of Annals of Applied Statistics, Statistics in Biosciences, PLOS Computational Biology, and Human Genetics and Genomics Advances. She is an elected member of the International Statistical Institute and a Fellow of the American Statistical Association.

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Wed, 24 Feb 2021 12:57:46 -0500 2021-03-10T16:00:00-05:00 2021-03-10T17:00:00-05:00 Off Campus Location DCMB Seminar Series Livestream / Virtual
BME 500 Seminar: George Christ (March 11, 2021 4:00pm) https://events.umich.edu/event/81389 81389-20889819@events.umich.edu Event Begins: Thursday, March 11, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Despite the well-documented capability of skeletal muscle to repair, regenerate, and remodel following injury, there remain a multitude of diseases, disorders, and traumatic injuries that result in irrecoverable loss of muscle structure and function. For example, volumetric muscle loss (VML) injuries are characterized by a degree of composite muscle tissue loss so severe, that it exceeds the native ability of the muscle to repair, thereby resulting in permanent cosmetic and functional deficits to the limbs, neck, or face. These injuries significantly impact both the civilian and military populations. Current treatment for VML injury involves surgical muscle transfer, although these procedures are often associated with both poor engraftment and donor site morbidity, as well as incomplete cosmesis and functional recovery. Not surprisingly, this unmet medical need has stimulated research efforts to develop new technologies for treatment of VML injuries. Recent attention has focused on development of tissue engineering (TE)/regenerative medicine (RM) technologies to provide more effective treatment options for large scale muscle injuries. A variety of preclinical approaches have been tried that include implantation of synthetic and/or natural extracellular matrices/scaffolds/constructs at the site of VML injury, both with and without a cellular component. Extant data indicate that the inclusion of a cellular component generally leads to a greater degree of functional improvement. Consistent with these preclinical results, recent clinical studies for treatment of VML injury, solely with implanted decellularized extracellular matrix scaffolds, have provided evidence for modest functional recovery but with little de novo muscle tissue regeneration at the injury site. More recently, bio-printed tissue engineered constructs and their potential applications to treatment of VML injury have been reported in the literature. While these initial clinical and preclinical observations are encouraging for the TE/RM paradigm, full structural and functional recovery has yet to be achieved, and thus, there remains significant room for therapeutic advancement. To this end, I will describe our highly collaborative efforts to boost development and evaluation of a range of implantable regenerative therapeutics (biomaterials and tissue engineered constructs) in biologically relevant animal models. The overall goal is to increase the efficiency of clinical translation of TE/RM technologies capable of more complete functional recovery following repair of VML injury.

ZOOM LINK: https://umich.zoom.us/j/94405051853

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Lecture / Discussion Mon, 08 Mar 2021 11:13:19 -0500 2021-03-11T16:00:00-05:00 2021-03-11T17:00:00-05:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
RNA Seminar featuring: James Nuñez, HHMI Hanna Gray Fellow, University of California, San Francisco (March 15, 2021 4:00pm) https://events.umich.edu/event/81286 81286-20881887@events.umich.edu Event Begins: Monday, March 15, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_f8wC8rrJQzuhYzTEXoW69Q


ABSTRACT
General approaches for heritably altering gene expression would enable many discovery and therapeutic efforts. I will present CRISPRoff— a programmable epigenetic memory writer consisting of a single dead Cas9 fusion protein that establishes DNA methylation and repressive histone modifications to turn off transcription. Transient CRISPRoff expression initiates highly specific DNA methylation and gene repression that is maintained through cell division and differentiation of stem cells to neurons. Pairing CRISPRoff with genome-wide screens and analysis of chromatin marks enabled us to explore the rules for heritable silencing. We identify sgRNAs capable of silencing the large majority of genes including those lacking canonical CpG islands (CGIs) and reveal a wide targeting window extending beyond annotated CGIs. Our finding that targeted DNA methylation outside of CGIs leads to memorized gene silencing expands the canonical model of methylation-based silencing and broadly enables diverse applications including genome-wide screens, multiplexed cell engineering, enhancer silencing, and mechanistic exploration of epigenetic inheritance.

KEYWORDS: CRISPR, transcription, epigenetics
Flyer in PDF: https://rna.umich.edu/wp-content/uploads/2021/02/Seminar-Flyer-03152021-Nunez.pdf

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Lecture / Discussion Thu, 18 Feb 2021 09:21:31 -0500 2021-03-15T16:00:00-04:00 2021-03-15T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion James Nunez, Ph.D. UCSF
Sociogenomics & Polygenic Scores (March 16, 2021 1:00pm) https://events.umich.edu/event/82258 82258-21060576@events.umich.edu Event Begins: Tuesday, March 16, 2021 1:00pm
Location: Off Campus Location
Organized By: Institute for Social Research

PDHP begins our 2021 workshop series on March 16th, with a workshop entitled Sociogenomics & Polygenic Scores, co-presented by Ben Domingue of Stanford University’s Graduate School of Education and Erin Ware of the University of Michigan Population Neurodevelopment & Genetics Group. This half-day workshop is geared toward data analysts interested in combining social science and genetic analysis, and will provide information on the recent history of sociogenomics and a novel approach for examining gene-by-environment interactions, as well as hands-on practice with state-of-art techniques in the field (including creating polygenic scores from simulated plink data using a high-performance computing environment).

Topics include:

• Recent history of sociogenomics
• A novel approach for examining gene-by-environment interactions
• Hands-on introduction to high-performance computing and genetic data types
• Computation of polygenic scores using PRSice2 software

Registration Required

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Workshop / Seminar Thu, 11 Mar 2021 13:27:58 -0500 2021-03-16T13:00:00-04:00 2021-03-16T17:00:00-04:00 Off Campus Location Institute for Social Research Workshop / Seminar Poster for Sociogenomics & Polygenic Scores
Science Success Series | Overcoming the Fear of Failure in Personal and Academic Pursuits (March 16, 2021 4:00pm) https://events.umich.edu/event/80594 80594-20759752@events.umich.edu Event Begins: Tuesday, March 16, 2021 4:00pm
Location: Off Campus Location
Organized By: Science Learning Center

In this workshop, we'll build on the lessons of growth mindset and put failure into practice, with activities that allow us to focus on the learning that goes along with mistakes. This way, we can create environments that allow for innovation, personal, and professional growth.

Register at: myumi.ch/1pBpO

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Workshop / Seminar Mon, 11 Jan 2021 11:37:45 -0500 2021-03-16T16:00:00-04:00 2021-03-16T17:30:00-04:00 Off Campus Location Science Learning Center Workshop / Seminar you can('t) do it
TSCA @ 5 Years: Opportunities to Act with Foresight (March 16, 2021 7:00pm) https://events.umich.edu/event/82485 82485-21108121@events.umich.edu Event Begins: Tuesday, March 16, 2021 7:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

The University of Michigan M-LEEaD Center is co-sponsoring an event to mark the 5-year anniversary of the bipartisan legislation called the Frank R. Lautenberg Chemical Safety for the 21st Century Act. This reform law was designed to modernize U.S. industrial chemical policy to promote health, but has it lived up to its promise?

Public understanding is limited regarding how exposures to toxic chemicals affect health and how they might be regulated. Unlike pharmaceuticals, industrial and commercial chemicals are rarely tested for safety before they reach the U.S. market. The 1976 TSCA has been widely acknowledged to be a weak and ineffective law, and widespread exposures and harms continue. In the U.S., everyone is exposed to industrial and toxic chemicals, dozens and probably hundreds – well before birth. The amount of chemicals manufactured and imported continues to grow – it is trillions of pounds – and these chemicals remain largely unregulated. At the same time, we have seen an increase in chronic diseases, such as diabetes, autism, and infertility. Not everyone is equally at risk, and a higher burden of disease falls on low wealth communities and communities of color. These health disparities in exposures and health effects are illustrated and exacerbated by COVID.

The amended TSCA gave the U.S. Environmental Protection Agency new requirements and authorities. The public health impact points to the need for the U.S. EPA to fully use its new powers to evaluate all risks from hazardous chemicals and set policies which protect health and are accountable to high-risk communities. Preventive actions are urgently needed.

Watch “THE FOREVER CHEMICALS” documentary (2019, 26 min) at Great Lakes Now then join the March 16 forum. https://www.greatlakesnow.org/fc
“The Forever Chemicals” is an Emmy-winning examination of the impact of PFAS contamination in west Michigan
communities.

LEARN MORE AT OUR LIVE VIRTUAL PANEL DISCUSSION (registration required) on March 16 with Sandra Svoboda, “The Forever Chemicals” co-producer and Great Lakes Now Program Director; Tracey Woodruff, PhD, MPH, Professor, Ob/Gyn, Reproductive Sciences, University of CA-San Francisco; and Justin Onwenu, Environmental Justice Organizer, Sierra Club. Moderated by Patricia Koman, MPP, PhD, Research Investigator, Environmental Health Sciences, University of Michigan with Welcoming remarks from Gilbert S. Omenn, MD, PhD, the Harold T Shapiro Distinguished University Professor of Medicine (also Professor of Computational Medicine & Bioinformatics; Internal Medicine; Human Genetics; and Public Health, Univ of Mich).

REGISTER HERE https://bit.ly/37I2JaU

SPONSORED BY the Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD) • U-M Environmental Health Sciences • Detroit Public Television • Wayne State CURES Center • U-M Sustainable Living Experience • UROP (U-M Undergraduate Research Opportunity Program) • UMIHSA (U-M Industrial Hygiene Students Association) • EHSA (Environmental Health Student Association) • American Chemical Society Outreach Organization • U-M Health Policy Student Association • Ecology Center • Michigan Environmental Justice Coalition • UCSF Program for Reproductive Health and the Environment • UCSF EaRTH Center

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Conference / Symposium Wed, 03 Mar 2021 12:57:09 -0500 2021-03-16T19:00:00-04:00 2021-03-16T20:30:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Conference / Symposium March 16 Panel Discussion: TSCA @ 5 Years
Game of Microbes: Natural Products as Weapons for Microbial Regulation in the Oral Cavity (March 17, 2021 9:00am) https://events.umich.edu/event/82901 82901-21211384@events.umich.edu Event Begins: Wednesday, March 17, 2021 9:00am
Location: Off Campus Location
Organized By: Michigan Microbiome Project

Abstract: Co-existence and intraspecies interactions in human microbiomes have been well studied over the past decade. In the human oral microbiome alone, you can find over 700 different microbial species at a given time. These microbial species can shape the microenvironment throughout the human body, by their microbial interactions mediated by secretion of chemical mediators (i.e. secondary metabolites). These interactions are paramount to maintaining oral health and systematic health. Several epidemiological studies have linked dysbiosis of oral microbes with cardiovascular disease, poor glycemic control in diabetics, low b rheumatoid arthritis and a number of other conditions. Through recent advances in technology, including next-generation sequencing (NGS) and bioinformatic tools, have helped to unravel the complexities of the oral microbiome. It is still not understood how microbial interactions are mediated within the oral cavity and how they affect oral and systemic health. Using a prospective, split mouth, experimental gingivitis model on 20 healthy non-smoking participants, we were able to observe metabolite profile changes in oral cavity during gingivitis progression and identify several small molecules that have regulatory properties in pathogenic oral microbial growth. With this research, we may be able to develop novel enhancers and pharmaceuticals for oral health and characterize molecules that can serve as biomarkers for oral and systemic diseases.

Hosts: Matthew Ostrowski, Thomas Schmidt

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Workshop / Seminar Tue, 09 Mar 2021 16:13:03 -0500 2021-03-17T09:00:00-04:00 2021-03-17T10:00:00-04:00 Off Campus Location Michigan Microbiome Project Workshop / Seminar Michigan Microbiome Project
CCMB / DCMB Weekly Seminar Series featuring Sriram Chandrasekaran (Assistant Professor, Biomedical Engineering) (March 17, 2021 4:00pm) https://events.umich.edu/event/82825 82825-21179592@events.umich.edu Event Begins: Wednesday, March 17, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract: Drug combinations have the potential to greatly expand our pharmacopeia while reducing both cost and drug resistance. Yet the current drug-discovery approach is unable to screen the astronomical number of possible combinations in different cell types and does not account for the complex environment inside the body. We have developed AI tools - INDIGO and MAGENTA - that predict the efficacy of drug combinations based on the properties of the drugs, the pathogen, and the infection environment. We are also using modeling to identify drugs that work in synergy with the host immune system. Using INDIGO and MAGENTA, we have identified highly synergistic combinations of repurposed drugs to treat drug resistant infections including Tuberculosis, the deadliest bacterial infection. INDIGO also accurately predicts the outcome of past clinical trials of drug combinations. Our ultimate goal is to create a personalized approach to treat infections using AI.
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Biography: Chandrasekaran received his bachelor’s degree in Biotechnology from Anna University in 2008, and a PhD in Biophysics from the University of Illinois at Urbana-Champaign in 2013. He worked at Harvard University and MIT as a Harvard Junior Fellow between 2013 and 2016 and became an Assistant Professor at UM in 2017. His lab develops systems biology algorithms for drug discovery. Computer models from his lab like INDIGO and MAGENTA are being used to design effective therapies against drug resistant pathogens. His lab also develops systems biology algorithms to understand metabolic regulation. The approaches that they have created (PROM, ASTRIX, DFA, EGEM and GEMINI) perform complementary functions in modeling of metabolic and regulatory networks. Chandrasekaran’s research has been published in Cell, Genome Biology, mBio, and PNAS. For his work, Chandrasekaran previously received the 2013 Harvard Junior Fellowship, the 2011 Howard Hughes Medical Institute (HHMI) International Predoctoral Fellowship, the 2014 William Milton Fund award, 2018 UM Precision Health Investigator Award, and the 2018 Distinguished Young Investigator Award from the AICHE COBRA society.


https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Fri, 05 Mar 2021 14:44:14 -0500 2021-03-17T16:00:00-04:00 2021-03-17T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual Sriram Chandrasekaran, PhD (Assistant Professor, Biomedical Engineering)
What Should Education Innovation at Michigan Medicine Be Known For? (March 18, 2021 12:00pm) https://events.umich.edu/event/82425 82425-21098206@events.umich.edu Event Begins: Thursday, March 18, 2021 12:00pm
Location: Off Campus Location
Organized By: RISE (Research. Innovation. Scholarship. Education.)

Please join us for our next Virtual Talking Circle on March 18 at 12:00 pm, where we will discuss how to construct a more cohesive direction for education innovation at our institution. What problems should we be focusing on? Where should we as an “innovation system” invest?

RISE will be working across our entire community to construct such a vision, a process suggested by previous Virtual Talking Circles, the RISE Advisory Council, and education leaders in the biomedical sciences, as well as undergraduate, graduate, and continuing medical education. A specific proposal will be presented for reflection and feedback by attendees, and we invite all of you to attend and provide input into this conversation.

Please also invite your colleagues who may be interested. See you then!

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Workshop / Seminar Tue, 23 Feb 2021 07:25:35 -0500 2021-03-18T12:00:00-04:00 2021-03-18T13:00:00-04:00 Off Campus Location RISE (Research. Innovation. Scholarship. Education.) Workshop / Seminar RISE Virtual Talking Circle
NeuroNetwork for Emerging Therapies Mini Symposium Series: Nutrition & Brain Health with The Henry Ford (March 18, 2021 2:00pm) https://events.umich.edu/event/82153 82153-21044613@events.umich.edu Event Begins: Thursday, March 18, 2021 2:00pm
Location: Off Campus Location
Organized By: NeuroNetwork for Emerging Therapies

"You are what you eat" is a common phrase that researchers and scientists are proving remarkably true. Unhealthy diets not only lead to obesity, but that obesity can even lead to cognitive decline, or a decreased ability to think.

The third installment of the NeuroNetwork for Emerging Therapies Mini Symposium Series will explore what unhealthy foods do to the nervous system, a historical look at the downhill trend of eating habits, and how everyone can find an optimal nutritional balance. These presentations will be followed by a question and answer session.

“Nutrition & Brain Health” is made possible by the generous support of Robert and Katherine Jacobs, who believe that informing people about healthy food options is critically important to the health of their community.

Eva Feldman, MD, PhD, Director of the NeuroNetwork for Emerging Therapies, will moderate the 30-minute mini symposium and discuss diet and brain health. Debra Reid, PhD, MA, Curator of Agriculture and the Environment at The Henry Ford, will discuss the history of the American diet and how urban residents obtained fresh fruits and vegetables from urban markets, such as the Central Farmers Market that is under reconstruction at Greenfield Village. Michigan Medicine Lead Dietitian Danielle Karsies, MS, RDN, will provide direction for how people can apply the information from Drs. Feldman and Reid to help them make better food choices.

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Conference / Symposium Tue, 16 Feb 2021 13:46:27 -0500 2021-03-18T14:00:00-04:00 2021-03-18T14:30:00-04:00 Off Campus Location NeuroNetwork for Emerging Therapies Conference / Symposium Nutrition & Brain Health with The Henry Ford
BME 500 Seminar: Daniel Rueckert (March 18, 2021 4:00pm) https://events.umich.edu/event/81390 81390-20889820@events.umich.edu Event Begins: Thursday, March 18, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Zoom Link: https://cwru.zoom.us/webinar/register/WN_tmHJ7ArQRyO01NN6SfYYtg

Hosted by Dr. Frederick Epstein

Seminar Abstract:
The talk will focus on the use of deep learning techniques for the discovery and quantification of clinically useful information from medical images. The talk will describe how deep learning can be used for the reconstruction of medical images from undersampled data, image super-resolution, image segmentation and image classification. It will also show the clinical utility of applications of deep learning for the interpretation of medical images in applications such as brain tumour segmentation, cardiac image analysis and applications in neonatal and fetal imaging. Finally, it will be discussed how deep learning may change the future of medical imaging. https://openbme.org/

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Lecture / Discussion Mon, 15 Mar 2021 14:07:10 -0400 2021-03-18T16:00:00-04:00 2021-03-18T17:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Where Do We Go From Here: Body Politics & Movement Towards Racial Empowerment (March 24, 2021 12:00pm) https://events.umich.edu/event/82828 82828-21179596@events.umich.edu Event Begins: Wednesday, March 24, 2021 12:00pm
Location: Off Campus Location
Organized By: School of Kinesiology

Please join us for the last event in our series addressing the theme: "Where Do We Go From Here: Body Politics and Movement Towards Racial Empowerment."

This event will consist of a panel featuring scholars and medical, mental health, and fitness experts discussing movement, and physical and mental wellness/well-being as ways of combatting the body politics of racism. The event will include panelists’ demonstrations and audience participation.

If you'd like to join along with the Afrobeats dance demonstration (and we hope you do), please wear comfortable clothes and use a space where you have room to move. All ages and abilities are welcome; no experience needed!

--Abigail Eiler, LMSW, MSW, QMHP: Clinical Assistant Professor, U-M School of Social Work; Director, Athletics Counseling, U-M Athletics; Chair, Mental Health & Wellness Cabinet, Big Ten Conference

--Chiamaka Ukachukwu, MS: PhD Candidate (Specializing in Cardiovascular Electrophysiology), U-M Department of Pharmacology; Afrobeats Dance Instructor, U-M Recreational Sports

--Dr. Kamaria Washington, DPT: Physical Therapist (Specializing in Pelvic Floor Concerns), Therapeutic Associates Bethany Physical Therapy (Portland, OR)

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Well-being Wed, 17 Mar 2021 17:58:46 -0400 2021-03-24T12:00:00-04:00 2021-03-24T13:30:00-04:00 Off Campus Location School of Kinesiology Well-being U-M Health Sciences - Where Do We Go From Here: Body Politics & Movement Towards Racial Empowerment
CCMB / DCMB Weekly Seminar Series Featuring Duncan K. Ralph (Fred Hutchinson Cancer Research Center) (March 24, 2021 4:00pm) https://events.umich.edu/event/82733 82733-21169592@events.umich.edu Event Begins: Wednesday, March 24, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract: Antibodies are an integral part of the adaptive immune response, and are a critical component of both vaccine-induced and naturally-acquired immunity. The development of deep sequencing approaches in recent years has allowed us to sample a significant fraction of the diverse repertoire of B cell receptor sequences from which antibodies are made. These sequences encode a wealth of information on the somatic rearrangement and evolutionary processes that determine the contours of our antibody repertoires, and thus our ability to respond appropriately to pathogens and vaccines. Extracting this information, however, requires a careful inference approach across several different analysis steps. I will describe the computational approaches that we have taken to solving these problems, which constitute the partis software package, and describe their application in several projects, including HIV and Dengue data.

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Biography: Duncan attended the University of California at Santa Cruz for his undergraduate studies in physics, completing his thesis on energy transport in condensed matter theory in 2005. He completed his PhD at the Massachusetts Institute of Technology in 2014, working on the Large Hadron Collider at the European particle physics laboratory (CERN). His thesis described the observation of Higgs boson decays to four leptons. Since 2014, he has worked in Frederick Matsen’s lab at the Fred Hutchinson Cancer Research Center, first as a postdoctoral researcher and more recently as a staff scientist, writing new computational methods for the analysis of B cell receptor deep sequencing data.

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Thu, 04 Mar 2021 11:20:24 -0500 2021-03-24T16:00:00-04:00 2021-03-24T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual
5th Annual RNA Symposium, "Processing RNA" (March 25, 2021 11:00am) https://events.umich.edu/event/80161 80161-20572609@events.umich.edu Event Begins: Thursday, March 25, 2021 11:00am
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

FOR MORE DETAILS & ABSTRACTS VISIT: https://rna.umich.edu/2021-symposium/

Thursday, March 25, 2021
11:00 / Welcome
11:05 / KEYNOTE 1: Tracy Johnson, UCLA, “RNA Splicing, Chromatin Modification, and the Coordinated Control of Gene expression”
12:00 / Short break
12:10 / KEYNOTE 2: Kevin Weeks, UNC, “Structure-Based Discovery of New Functions in Large RNAs”
1:05 / Data Blitz: Cathy Smith, Daniel Peltier, Yan Zhang
1:35 / KEYNOTE 3: Feng Zhang, MIT, “Exploration of Biological Diversity to Discover Novel Molecular Technologies”
2:30 / Close Day 1

Friday, March 26, 2021
11:00 / Welcome
11:05 / KEYNOTE 4: Brenda Bass, University of Utah, “Distinguishing self and non-self dsRNA in vertebrates and invertebrates”
12:00 / Short break
12:10 / KEYNOTE 5: Christopher Lima, Sloan-Kettering Institute, “Mechanisms that target RNA for destruction”
1:05 / Data Blitz: Meredith Purchal, Adrien Chauvier, Shannon Wright
1:35 / Panel discussion with keynote speakers
2:30 / Close Day 2

Liveblogging by MiSciWriters! https://misciwriters.com/

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Lecture / Discussion Tue, 23 Mar 2021 15:03:26 -0400 2021-03-25T11:00:00-04:00 2021-03-25T14:30:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion 5th Annual RNA Symposium
LHS Collaboratory March Session (March 25, 2021 12:00pm) https://events.umich.edu/event/82008 82008-21006745@events.umich.edu Event Begins: Thursday, March 25, 2021 12:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Speakers Stefan Boes, PhD and Sarah Mantwill, PhD from the university of Lucerne will discuss the Swiss Learning Health System.

Promoting and supporting uptake of evidence and evidence-informed decision-making in health-systems related policy and practice is a challenge. In Switzerland, the need to address this matter has been increasingly emphasized by different actors in the health system. In particular, the lack of comprehensive coordination efforts in the field of health services research, and subsequent knowledge translation activities, has been stressed. In response, the Swiss Learning Health System (SLHS) was established as a nationwide project in 2017, currently involving 10 academic partner institutions. One of the overarching objectives of the SLHS is to bridge research, policy, and practice by providing an infrastructure that supports learning cycles by: continuously identifying issues relevant to the Swiss health system, systemizing relevant evidence, presenting potential courses of action, and revising and reshaping responses. Key features of learning cycles in the SLHS include the development of policy/evidence briefs that serve as a basis for stakeholder dialogues with actors from research, policy and practice. Issues that are identified to be further pursued are monitored for potential implementation and eventually evaluated to inform new learning cycles and to support continuous learning within the system.

Dr. Boes and Dr. Mantwill will provide an overview of the SLHS and its key features, as well as its capacity building efforts to train young researchers in the field of learning health systems, and the development of a centralized metadata repository in support of creating a sufficient large evidence basis to support learning cycles in the Swiss health system. Further, they will discuss lessons learned from the past and the newest developments of the SLHS in light of a second funding phase supported by the Swiss government.

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Livestream / Virtual Thu, 25 Feb 2021 23:57:27 -0500 2021-03-25T12:00:00-04:00 2021-03-25T13:30:00-04:00 Off Campus Location Department of Learning Health Sciences Livestream / Virtual LHS Collaboratory Logo
BME 500 Seminar: Warren L. Grayson (March 25, 2021 4:00pm) https://events.umich.edu/event/81391 81391-20889821@events.umich.edu Event Begins: Thursday, March 25, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Tissue engineering provides a viable means of regenerating bone and skeletal muscle tissues following injuries that lead to large volumetric defects. Our lab has developed advanced biomaterial and stem cell-based approaches to promote functional recovery following volumetric muscle loss and critical-sized craniofacial bone injuries. This presentation will focus on three areas of ongoing research: (1) I will present our lab’s efforts to regenerate vascularized and innervated skeletal muscle in mice including our recent studies using human pluripotent stem cells. (2) Recently, our group completed a study focused on designing biomaterials to guide bone regeneration in situ in minipigs using intraoperative protocols for combining autologous stem cells with 3D-printed scaffolds. (3) Understanding the interaction between vascular cells and osteoprogenitors is critical for developing effective treatment methods. I will describe recent studies in which we developed a quantitative imaging platform for characterizing the spatial relationships between cell populations in the native murine calvarium. https://openbme.org/

ZOOM LINK TO REGISTER: https://cwru.zoom.us/webinar/register/WN_Kgyl3yf4TcKvlk9xNKluhA

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Lecture / Discussion Sun, 21 Mar 2021 17:46:23 -0400 2021-03-25T16:00:00-04:00 2021-03-25T17:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
5th Annual RNA Symposium, "Processing RNA" (March 26, 2021 11:00am) https://events.umich.edu/event/80161 80161-20572610@events.umich.edu Event Begins: Friday, March 26, 2021 11:00am
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

FOR MORE DETAILS & ABSTRACTS VISIT: https://rna.umich.edu/2021-symposium/

Thursday, March 25, 2021
11:00 / Welcome
11:05 / KEYNOTE 1: Tracy Johnson, UCLA, “RNA Splicing, Chromatin Modification, and the Coordinated Control of Gene expression”
12:00 / Short break
12:10 / KEYNOTE 2: Kevin Weeks, UNC, “Structure-Based Discovery of New Functions in Large RNAs”
1:05 / Data Blitz: Cathy Smith, Daniel Peltier, Yan Zhang
1:35 / KEYNOTE 3: Feng Zhang, MIT, “Exploration of Biological Diversity to Discover Novel Molecular Technologies”
2:30 / Close Day 1

Friday, March 26, 2021
11:00 / Welcome
11:05 / KEYNOTE 4: Brenda Bass, University of Utah, “Distinguishing self and non-self dsRNA in vertebrates and invertebrates”
12:00 / Short break
12:10 / KEYNOTE 5: Christopher Lima, Sloan-Kettering Institute, “Mechanisms that target RNA for destruction”
1:05 / Data Blitz: Meredith Purchal, Adrien Chauvier, Shannon Wright
1:35 / Panel discussion with keynote speakers
2:30 / Close Day 2

Liveblogging by MiSciWriters! https://misciwriters.com/

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Lecture / Discussion Tue, 23 Mar 2021 15:03:26 -0400 2021-03-26T11:00:00-04:00 2021-03-26T14:30:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion 5th Annual RNA Symposium
CCMB / DCMB Weekly Seminar (March 31, 2021 4:00pm) https://events.umich.edu/event/83395 83395-21369780@events.umich.edu Event Begins: Wednesday, March 31, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

Large, deeply phenotyped cohorts are reshaping the world of environmental epidemiology. Two such “big data” resources that are reshaping how we understand environmental health are electronic health records and human cohorts with genome-wide molecular phenotyping. Each provides a unique perspective that is moving the field closer towards “personalized” insights into environmental health risks. Here I will talk about a series of studies which utilize electronic health records and molecularly phenotyped cohorts to investigate vulnerable populations, gene-environment interactions, and epigenetic biomarkers of environmental sensitivity. Together these studies are helping us to understand environmental health risks in a new light.

Short bio:

Dr. Cavin Ward-Caviness is a Principal Investigator in the Public Health and Integrated Toxicology Division of the US Environmental Protection Agency. With a background in computational biology and environmental epidemiology, Dr. Ward-Caviness seeks to understand the environmental factors which influence health in vulnerable populations and the molecular mechanisms that influence environmental health risks. The Ward-Caviness lab uses a variety of “big data” approaches, and Dr. Ward-Caviness is the PI of the EPA CARES research resource, which allows researchers to study environmental health effects in vulnerable patient populations, e.g. individuals with heart failure, using large electronic health record databases. Dr. Ward-Caviness is also interested in how epigenetics and metabolomics can serve as an early indicator of adverse health effects from chemical and social environmental exposures and in particular how molecular biomarkers can give us insight into how the environment may accelerate the aging process and thus contribute to chronic disease. By integrating molecular and clinical data, Dr. Ward-Caviness seeks to understand environmental health as a way to advance personalized medicine and reduce health disparities.

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Mon, 29 Mar 2021 15:15:11 -0400 2021-03-31T16:00:00-04:00 2021-03-31T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual
LSI Seminar Series: Ginger Hunter, Ph.D., Clarkson University (April 1, 2021 12:00pm) https://events.umich.edu/event/82695 82695-21161629@events.umich.edu Event Begins: Thursday, April 1, 2021 12:00pm
Location: Off Campus Location
Organized By: Life Sciences Institute (LSI)

Abstract:
The ability of Notch signaling to drive a broad range of contact-mediated cell fate determination events relies, in part, on dynamic cell shape changes and cell contractility. Both of these behaviors require the activity of the cytoskeleton. Dynamic cell shape changes, like the formation of filopodia, allow distant cells to target and engage in signaling with each other. One example of this is the patterning of sensory bristles on the thorax of the fruit fly Drosophila melanogaster. In this tissue, cellular protrusions are thin, dynamic, actin-based, filopodia-like structures which extend from the basal surface of the patterning epithelia. In this talk, Ginger Hunter, Ph.D., will present data supporting a role for these basal signaling filopodia in establishing the length scale of the bristle pattern. Cell contractility is an essential feature of epithelial tissue integrity. Hunter shows that contractility, mediated by actin and non-muscle myosin II, is critical for the efficiency of Notch signaling. Together, these results support a role for cell shape and actomyosin contractility in Notch signaling during bristle patterning.

Speaker:
Ginger Hunter is an Assistant Professor of Biology at Clarkson University in Potsdam, New York. She earned her B.S. from the University of Virginia and her Ph.D. from Duke University, where she studied mechanosensing in developing tissues in the fly embryo. She continued her studies into the mechanisms of emergent features of developing tissues during her postdoctoral training at the MRC-LMCB at University College London and the National Institute of Neurological Disorders and Stroke. Hunter opened her laboratory at Clarkson in 2018. One goal of her lab is to understand the regulation of cell morphology, such as the activity of signaling filopodia, that contribute to the robust formation of tissue wide patterns.

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Workshop / Seminar Wed, 03 Mar 2021 09:27:24 -0500 2021-04-01T12:00:00-04:00 2021-04-01T13:00:00-04:00 Off Campus Location Life Sciences Institute (LSI) Workshop / Seminar LSI Seminar Series logo
BME 500 Seminar: Tim Downing (April 1, 2021 4:00pm) https://events.umich.edu/event/81392 81392-20889822@events.umich.edu Event Begins: Thursday, April 1, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

https://openbme.org/

ZOOM LINK TO REGISTER: https://cwru.zoom.us/webinar/register/WN_iY_PMZevQwWRYkMyK7ifzA

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Lecture / Discussion Fri, 26 Mar 2021 14:01:59 -0400 2021-04-01T16:00:00-04:00 2021-04-01T17:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
BME Seminar: Synthetic Genome Engineering for Cell and Tissue Engineering (April 1, 2021 4:00pm) https://events.umich.edu/event/80692 80692-20783435@events.umich.edu Event Begins: Thursday, April 1, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Title: Synthetic Genome Regulation for Cell and Tissue Engineering

Abstract: Molecular heterogeneity is emerging as a critical feature of multicellular life. While single-cell analyses have revealed the existence of cell-to-cell variation in the levels and activities of the molecules responsible for gene regulation, the source of such variation is still poorly understood. The Downing Lab studies how genome replication contributes to epigenetic heterogeneity across stem cell populations. We recently developed a new sequencing method (Repli-Bisulfite Sequencing) that enables analysis of DNA methylation within newly replicated strands of DNA over time. Using this method, we discovered that much of the methylation heterogeneity observed within human embryonic stem cells (hESCs) is temporal in nature and associated with DNA replication. Here, we employ bioinformatic analyses to explore how properties of post-replication DNA methylation dynamics relate to well-established features of the genome and the broader chromatin landscape. Our findings reveal that unique patterns of methylome replication associate with distal regulatory regions throughout the genome, enrich for cytosine residues dynamically methylated across cell types, and coincide with the location of stem cell-specific transcription factor binding and chromatin architectures. We also find correlations between sub-cell cycle kinetics in DNA methylation and the divergence of bulk methylation patterns observed during multiple cell generations and natural aging. Taken together, our studies suggest that (epi)genome replication may act as an important source of (temporal) regulatory variation in hESCs while, simultaneously, conferring susceptibility to epigenetic drift throughout the human lifespan. Our lab is also interested in understanding how the chemical and biophysical microenvironment influences adult cell behavior and phenotype through epigenetic gene regulatory mechanisms. We hope to use this information in the design of next-generation biomaterials. The second part of this presentation will describe how focal adhesions and cell-mediated forces contribute to inefficiencies observed during the acquisition of stemness from somatic cell states.



Biography: Tim Downing has been on the faculty at UC Irvine since 2016 and holds a primary appointment in the Department of Biomedical Engineering. He also holds a courtesy appointment in the Department of Microbiology & Molecular Genetics. Tim received his B.S. in Chemical Engineering in 2008 from Northwestern University and Ph.D. in Bioengineering from UC Berkeley in 2013 under the mentorship of Dr. Song Li. As a Ford Foundation and UNCF/Merck Fellow, Tim completed his postdoctoral training in stem cell epigenomics with Dr. Alexander Meissner at Harvard University and the Broad Institute (Cambridge, Massachusetts). The Downing Lab focuses on understanding gene regulation during tissue development, regeneration, and disease progression. Building on this information, the lab also aims to develop molecular tools and biomaterials to synthetically regulate the epigenome for better control over cell fate and behavior. Tim is a 2019 NIH (DP2) New Innovator Award recipient and a 2020 recipient of the “Rising Star” Award from the Cellular and Molecular Bioengineering (CMBE) Special Interest Group within the Biomedical Engineering Society (BMES).

Zoom Registration Link: https://cwru.zoom.us/webinar/register/WN_iY_PMZevQwWRYkMyK7ifzA

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Workshop / Seminar Thu, 25 Mar 2021 13:09:17 -0400 2021-04-01T16:00:00-04:00 2021-04-01T17:00:00-04:00 Off Campus Location Biomedical Engineering Workshop / Seminar Dr. Timothy L. Downing, UC Irvine
RNA Seminar featuring: Natoya Peart, PhD, University of Pennsylvania (April 5, 2021 4:00pm) https://events.umich.edu/event/81288 81288-20881888@events.umich.edu Event Begins: Monday, April 5, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

Registration required: https://umich.zoom.us/webinar/register/WN_0lUfePb0Qdac-cQZDpeiEQ


KEYWORDS: Alternative splicing, RNAMap, Esrp1

ABSTRACT: Coordinated regulation of alternative splicing is essential to the establishment of cell identity. The Epithelial Splicing Regulatory Proteins (Esrps), ESRP1 and ESRP2, are highly conserved paralogous proteins required for organogenesis of multiple organ systems and compromised function of Esrps contributes to human diseases and pathologies. Esrps are robustly expressed in the epithelial cells of the epidermis, large and small intestines, salivary glands, stomach, and a variety of other tissues, where they are vital in promoting an epithelial splicing network. Although ESRP1 and ESRP2 share partial functional redundancy, ESRP1 appears to play a larger role in regulating gene expression.
Using a combination of enhanced immunoprecipitation coupled with high throughput sequencing (eCLIP) in the epithelial cells of mouse epidermis and RNA sequencing analysis of alterations in splicing and total gene expression that result from epidermal ablation of Esrp1 and Esrp2 we generate a map of Esrp1 binding to RNA. We show that ESRP1 regulates splicing primarily through direct binding in a position-dependent manner to either promote exon inclusion or skipping. In particular, we show that Esrp1 binding upstream of or withing alternatively spliced exons suppresses exon inclusion, whilst binding downstream of the non-constitutive exon promotes exon inclusion. In addition, we identified widespread binding of ESRP1 in 3’ and 5’ untranslated regions (UTRs) of genes enriched for epithelial cell function suggesting that it directly regulates post-transcriptional gene expression steps in addition to splicing.


If you are having difficulties registering, please contact Martina Jerant at mjerant@umich.edu

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Lecture / Discussion Mon, 08 Mar 2021 12:23:08 -0500 2021-04-05T16:00:00-04:00 2021-04-05T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Natoya Peart, PhD, University of Pennsylvania
Microbiome Seminar: Risk factors for Clostridioides difficile infections: beyond antibiotics (April 7, 2021 9:00am) https://events.umich.edu/event/83521 83521-21397362@events.umich.edu Event Begins: Wednesday, April 7, 2021 9:00am
Location: Off Campus Location
Organized By: Michigan Microbiome Project

Postdoctoral Research Fellow, Lab PI, Schloss lab
Microbiology and Immunology, Michigan Medicine

Hosts:Matthew Ostrowski Ph.D. & Thomas Schmidt, Ph.D.

Abstract: Antibiotics are a major risk factor for Clostridioides difficile infections (CDIs) because of their impact on the intestinal microbiome. However, antibiotics are not the only drugs that alter the microbiome. In human cohorts, we have identified microbiota features that overlap between patients with CDIs or diarrhea, leading to our hypothesis that some patients with diarrhea are susceptible to C. difficile infection but have not been exposed to C. difficile spores. To examine how diarrhea impacts CDI susceptibility, we treated C57Bl/6 mice with 5-day and 1-day doses of 15% polyethylene glycol (PEG) 3350 in the drinking water and then challenged the mice with C. difficile 630 spores. We used clindamycin-treated mice as a control because they consistently clear C. difficile within 10 days post-infection (dpi). We also examined how PEG treatment impacts C. difficile clearance, by administering PEG for 1 day to clindamycin-treated, C. difficile-challenged mice. PEG treatment alone was sufficient to render mice susceptible to CDI and 5-day PEG-treated mice remain colonized for up to 30 dpi. In contrast, 1-day PEG treated mice were transiently colonized, clearing C. difficile within 7 dpi. Although 5-day PEG-treated mice exhibited prolonged C. difficile colonization, we saw no difference in histological inflammation between PEG- and clindamycin-treated mice. Additionally, administering PEG to mice after C. difficile challenge prolonged colonization up to 30 dpi in mice that received PEG immediately after challenge and 15 dpi in mice that received PEG 3 dpi. When we examined microbiota composition across the different treatment groups, we found there were increased Bacteroides and Enterobacteriaceae and decreased Lachnospiraceae and Oscillibacter in most of the PEG-treated mice with prolonged C. difficile colonization. Our findings suggest the osmotic laxative PEG 3350 alters the mouse microbiota and disrupts colonization resistance to C. difficile, as well as clearance in mice with a CDI. Further studies are needed to evaluate if laxatives impact human microbiota colonization resistance.

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Workshop / Seminar Fri, 02 Apr 2021 09:56:19 -0400 2021-04-07T09:00:00-04:00 2021-04-07T10:00:00-04:00 Off Campus Location Michigan Microbiome Project Workshop / Seminar Michigan Microbiome Project
Biointerfaces Institute Distinguished Lectureship Series (April 7, 2021 1:00pm) https://events.umich.edu/event/83431 83431-21377664@events.umich.edu Event Begins: Wednesday, April 7, 2021 1:00pm
Location: Off Campus Location
Organized By: Biointerfaces Institute

Lecture Title:
Droplet Microfluidics for Ultra-High Throughput Screening and Super Sensitive Detection

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Workshop / Seminar Tue, 30 Mar 2021 14:19:46 -0400 2021-04-07T13:00:00-04:00 2021-04-07T14:00:00-04:00 Off Campus Location Biointerfaces Institute Workshop / Seminar Seminar Flyer
CCMB / DCMB Weekly Seminar Series (April 7, 2021 4:00pm) https://events.umich.edu/event/83241 83241-21320453@events.umich.edu Event Begins: Wednesday, April 7, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract: More than 3,000 new Marine recruits were studied prospectively during their initial Marine-mandated two-week quarantine and their subsequent basic training at Parris Island. The COVID Health Action Response for Marines (CHARM) studied completed 20,000 study visits and obtained more than 70,000 biosamples including pre- to post- SARS-CoV-2 infections in more than 1000 recruits. Serological, transcriptomic, and epigenetic analyses identify the response signature to SARS-CoV-2 infection in these largely asymptomatic young adults. Phylogenetic analysis and modeling provide insight into epidemiology and guidance for public health measures.

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Specialty: Neurology

Research Topics: Addiction, Apoptosis/Cell Death, Basal Ganglia, Bioinformatics, Brain, Cellular Immunity, Cerebral Cortex, Mathematical and Computational Biology, Multiple Sclerosis, Neuro-degeneration/protection, Receptors, Reproductive Biology, Signal Transduction, Theoretical Biology, Vaccine Development, Viruses and Virology

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Tue, 23 Mar 2021 11:23:58 -0400 2021-04-07T16:00:00-04:00 2021-04-07T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual
BME 500 Seminar: James Collins (April 8, 2021 4:00pm) https://events.umich.edu/event/81393 81393-20889823@events.umich.edu Event Begins: Thursday, April 8, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

James Collins, Ph.D.
Massachusetts Institute of Technology

https://openbme.org/

ZOOM LINK TO REGISTER: https://cwru.zoom.us/webinar/register/WN_MSUiecgNTLyXR5bM8HSnR

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Lecture / Discussion Fri, 02 Apr 2021 15:01:39 -0400 2021-04-08T16:00:00-04:00 2021-04-08T17:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Science Success Series- Wealth Beyond Health (April 12, 2021 6:00pm) https://events.umich.edu/event/79930 79930-20515562@events.umich.edu Event Begins: Monday, April 12, 2021 6:00pm
Location: Off Campus Location
Organized By: Women in Science and Engineering (WISE) Program

There are limitless options for a pre-med student beyond medical school and a traditional career as a doctor. Join us in exploration of other career tracks with alumni and experts. There is a world of options to apply skills in science, critical problem solving, and a desire to help people. Find your option for graduate school as a STEM student.

We will have a panel of current graduate students who talk about how they chose their program, what the application was like, how they got in, and how it is going. Learn the whole process from start to finish with students who have been in your shoes.

Register here:
https://myumi.ch/PlQlP

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Workshop / Seminar Tue, 30 Mar 2021 12:58:23 -0400 2021-04-12T18:00:00-04:00 2021-04-12T19:00:00-04:00 Off Campus Location Women in Science and Engineering (WISE) Program Workshop / Seminar
Environmental Racism & Environmental Justice (April 13, 2021 12:00pm) https://events.umich.edu/event/83622 83622-21440409@events.umich.edu Event Begins: Tuesday, April 13, 2021 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Featuring Donele Wilkins (CEO, Green Door Initiative, Detroit) and Kathryn Savoie (Detroit Community Health Director, Ecology Center) with welcome and introductions by Amy Schulz (Professor HBHE, UM SPH). https://umich.zoom.us/j/91685410400

Final in this Series: April 20 "Community Action to Promote Healthy Environments: Research to Improve Air Quality and Health in Detroit".

Webinar series organized by the Community Engagement Core and the Integrated Health Sciences Core of the Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD). Co-sponsored by the DEI Committee of Health Behavior & Health Education and the DEI Committee of the Department of Environmental Health Sciences.

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Lecture / Discussion Wed, 07 Apr 2021 18:05:04 -0400 2021-04-13T12:00:00-04:00 2021-04-13T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Environmental Racism & Environmental Justice
Can Education Innovation at Michigan Medicine Benefit from Being More Cohesive? (April 14, 2021 12:00pm) https://events.umich.edu/event/83220 83220-21314487@events.umich.edu Event Begins: Wednesday, April 14, 2021 12:00pm
Location: Off Campus Location
Organized By: RISE (Research. Innovation. Scholarship. Education.)

RISE invites you attend the Virtual Talking Circle (VTC) to contribute your input in co-creating a cohesive pathway for education innovation across health science education at Michigan Medicine.  We invite you to attend and provide your input into this conversation.

Please invite your colleagues who may also be interested. See you then!

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Workshop / Seminar Wed, 24 Mar 2021 14:31:47 -0400 2021-04-14T12:00:00-04:00 2021-04-14T13:00:00-04:00 Off Campus Location RISE (Research. Innovation. Scholarship. Education.) Workshop / Seminar RISE Virtual Talking Circle
LSI SciComm Speaker Series: Jacqueline Howard (April 14, 2021 12:00pm) https://events.umich.edu/event/83506 83506-21393430@events.umich.edu Event Begins: Wednesday, April 14, 2021 12:00pm
Location: Off Campus Location
Organized By: Life Sciences Institute (LSI)

CNN Health reporter Jacqueline Howard will deliver the Life Sciences Institute SciComm Speaker Series’ lecture "Communicating Science In A Global Pandemic." Howard has been covering the coronavirus pandemic from the start for CNN, appearing in dozens of TV segments and writing more than 100 stories about the novel virus that causes Covid-19, its impacts on public health and the development of vaccines. Howard will discuss the challenges and importance of communicating science amid a global health crisis. For Howard, effective science communication can combat misinformation, and she will share criteria any piece of science communication can include to help inform public dialogue and news coverage.

Jacqueline Howard is a health reporter for CNN, covering the latest news in medicine and healthy living. She appears on CNN’s morning show New Day and the afternoon programs CNN Right Now and CNN Newsroom. She was a 2019 National Fellow at the USC Annenberg Center for Health Journalism and a 2020 Press Fellow at the United Nations Foundation. Previously, Howard served as senior science editor at The Huffington Post and the host/producer of the video series “Talk Nerdy To Me.” She has appeared on The Steve Harvey Show to discuss health trends and served as the on-air talent in a series of educational videos for The Nature Conservancy, the Bill and Melinda Gates Foundation and the Big History Project. She holds a master’s degree in journalism from the University of Southern California’s Annenberg School for Communication & Journalism, and a bachelor’s degree in communication studies from the University of Michigan-Ann Arbor.

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Workshop / Seminar Thu, 01 Apr 2021 15:39:30 -0400 2021-04-14T12:00:00-04:00 2021-04-14T13:00:00-04:00 Off Campus Location Life Sciences Institute (LSI) Workshop / Seminar CNN Health Reporter Jacqueline Howard
CCMB / DCMB Weekly Seminar (April 14, 2021 4:00pm) https://events.umich.edu/event/83595 83595-21436485@events.umich.edu Event Begins: Wednesday, April 14, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:
My lab's research involves the development and application of systems biology approaches—combining computation, machine learning, quantitative modeling, and experiments—to study the immune system in health and disease. Recent technological and computational advances allow comprehensive interrogation of multiple modalities (e.g., proteins, mRNAs, immune receptor sequences) in single cell resolution in the human population. Here I will highlight our work in the analysis human and single cell variations along the axes of early immune development, vaccination, and COVID-19. If time permits, I will also discuss the integration of tissue imaging, machine learning, and multiscale dynamical modeling of immune cell interactions to investigate the homeostatic regulation of autoreactive T cells.

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Biography: Dr. Tsang is a senior investigator in the NIH Intramural Research Program and leads a laboratory focusing on systems and quantitative immunology at the National Institute of Allergy and Infectious Diseases (NIAID). He also co-directs the Trans-NIH Center for Human Immunology (CHI) and leads its research program in systems human immunology. Dr. Tsang trained in computer engineering and computer science at the University of Waterloo and received his Ph.D. in biophysics from Harvard University. Dr. Tsang has worked as a software engineer and pursued systems biology research in both academia and industry including Rosetta Inpharmatics, Caprion Proteomics, MIT, and Merck Research Laboratories. Dr. Tsang has won several awards for his research, including NIAID Merit Awards for the development of a data reuse and crowdsourcing platform OMiCC and for leading a system biology study of human immune variability and influenza vaccination, which was selected as a top NIAID Research Advances of 2014. He currently serves as the founding chief editor of systems immunology for Frontiers in Immunology. He has served as a scientific advisor for a number of programs and organizations including ImmPort (the clinical and molecular data repository for NIAID), the Committee on Precision Medicine for the World Allergy Organization, the NIAID Modeling Immunity for Biodefense Program, the Allen Institute, the Immuno-Epidemiology Program at the National Cancer Institute, and the Human Vaccines Project.

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Wed, 07 Apr 2021 08:59:05 -0400 2021-04-14T16:00:00-04:00 2021-04-14T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual
BME 500 Seminar: Kelly J. Cross (April 15, 2021 4:00pm) https://events.umich.edu/event/81394 81394-20889824@events.umich.edu Event Begins: Thursday, April 15, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Join us for a virtual seminar series on topics related to race and science, technology, engineering and math (STEM) education. https://happenings.wustl.edu/event/an_honest_conversation_about_inequity_in_engineering#.YG9vT-hKhPY

Details:
DATE: Thursday, April 15, 2021
TIME: 4:00-5:00 PM
ZOOM LINK TO REGISTER: https://wustl.zoom.us/webinar/register/WN_NvH4qVTSRx2uSXbdW-eXNA

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Lecture / Discussion Wed, 14 Apr 2021 14:13:34 -0400 2021-04-15T16:00:00-04:00 2021-04-15T17:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
BME Master's Defense: Fatimah Alkaabi (April 16, 2021 12:00pm) https://events.umich.edu/event/83558 83558-21424731@events.umich.edu Event Begins: Friday, April 16, 2021 12:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

The central auditory system consists of the brain nuclei that transmit peripheral auditory nerve input to the auditory cortex for hearing perception. Damage to the auditory end organ, the cochlea, can result in hearing loss that drives the central auditory system to disarray causing disorders such as hyperacusis and tinnitus. These disorders can negatively affect patients’ quality of life. Tinnitus sufferers generally describe their tinnitus as a narrowband of sound that occurs in quiet, while hyperacusis sufferers express an exaggerated perception of sound level or intensity. These two disorders are often grouped together because tinnitus sufferers tend to report symptoms of hyperacusis and vice versa. However, hyperacusis and tinnitus do not always co-occur, suggesting that they have different neural origins. To study these conditions, researchers have induced cochlear damage in animal models, followed by behavioral and electrophysiological assessments. However, no study has adequately distinguished hyperacusis from tinnitus in individual animals. In this thesis, I detail the development of a novel hyperacusis and tinnitus assessment paradigm for individual animals using the pinna reflex combined with auditory brainstem responses (ABR). In the first chapter, I detail several enhancements to a computer system that ensures accurate sound presentation concurrently with capture of pinna reflex video data, as well as streamlines the subsequent data analysis. In the second chapter, the ABR, an evoked potential reflecting the summed electrical activity of cells in the auditory brainstem pathway, was assessed. Several studies suggest that ABR-wave characteristics might provide evidence of hyperacusis. ABRs were evoked using conventional and novel sound stimuli. They were then examined to look for possible indications of hyperacusis in noise overexposed guinea pigs. The present findings are discussed with several suggestions for future hyperacusis assessments.



Date: Friday, April 16, 2021

Time: 12:00 PM

Zoom: https://umich.zoom.us/j/91698183229

Chair: Dr. Susan Shore

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Lecture / Discussion Mon, 05 Apr 2021 23:04:39 -0400 2021-04-16T12:00:00-04:00 2021-04-16T13:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
RNA Seminar featuring: Jailson (Jay) Brito Querido, Ph.D. MRC Laboratory of Molecular Biology, Cambridge, UK (April 19, 2021 4:00pm) https://events.umich.edu/event/81408 81408-20893767@events.umich.edu Event Begins: Monday, April 19, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_78YYOhIhTbOBy2_JSdM7Wg

ABSTRACT: A key step in translational initiation is the recruitment of the 43S pre-initiation complex (43S PIC) by the cap-binding complex (eIF4F) at the 5´ end of mRNA. Eukaryotic initiation factors eIF1, eIF1A, eIF3, eIF5, and the ternary complex (TC) of eIF2–GTP–tRNAiMet bind to the 40S ribosomal subunit to form the 43S PIC. Once assembled, the 43S PIC is recruited to the cap-binding complex eIF4F at the 5´end of mRNA to form a 48S initiation complex (48S). The 48S then scans along the mRNA to locate a start codon. To understand the mechanisms involved, we determined the structure of a reconstituted human 48S using cryo-electron microscopy. The structure reveals insights into early events of translation initiation complex assembly. It reveals how eIF4F interacts with subunits of the eIF3 structural core near the mRNA exit channel in the 43S. The location of eIF4F is consistent with a slotting model of mRNA recruitment and suggests a “blind-region” that would preclude recognition of start sites upstream of the location of the P site at the point of recruitment.

KEYWORDS: mRNA, ribosome, eIF4F, eIF4A, translation

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Lecture / Discussion Tue, 13 Apr 2021 12:58:40 -0400 2021-04-19T16:00:00-04:00 2021-04-19T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Jailson (Jay) Brito Querido, Ph.D.
Community Action to Promote Healthy Environments: Research to Improve Air Quality & Health in Detroit (April 20, 2021 12:00pm) https://events.umich.edu/event/83634 83634-21446267@events.umich.edu Event Begins: Tuesday, April 20, 2021 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Join us on Zoom as we discuss 'Community Action to Promote Healthy Environments: Research to Improve Air Quality and Health in Detroit' featuring Angela Reyes (Detroit Hispanic Development Corporation), Stuart Batterman (Environmental Health Sciences, UM SPH), and Amy Schulz (Health Behavior & Health Education, UM SPH). (Rescheduled from Feb 9.)

https://umich.zoom.us/j/96155698295

Webinar series organized by the Community Engagement Core and the Integrated Health Sciences Core of the Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD). Co-sponsored by the DEI Committee of Health Behavior & Health Education and the DEI Committee of the Department of Environmental Health Sciences.

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Lecture / Discussion Thu, 08 Apr 2021 13:08:12 -0400 2021-04-20T12:00:00-04:00 2021-04-20T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Community Action to Promote Healthy Environments in Detroit
Links Between Culture and Sanitation (April 20, 2021 2:00pm) https://events.umich.edu/event/83816 83816-21540180@events.umich.edu Event Begins: Tuesday, April 20, 2021 2:00pm
Location:
Organized By: Project RISHI

Dr. Balmurli Natrajan, Professor of Anthropology at William Paterson University will speak on the social practices in communities where open defecation is prevalent, toilet use, and sanitation practices in India. The discussion will center around the link between culture and accepting modern adaptations in rural communities. RSVP Here: https://docs.google.com/forms/d/e/1FAIpQLSdaJwRFl1WH56j3j604SnuPiLF5vRvgiAHais0Hse4ISjAATA/viewform

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Conference / Symposium Tue, 20 Apr 2021 14:07:20 -0400 2021-04-20T14:00:00-04:00 2021-04-20T15:00:00-04:00 Project RISHI Conference / Symposium Dr. Balmurli Natrajan, Professor of Anthropology at William Paterson University
Master's Defense: Annie Taylor (April 21, 2021 10:30am) https://events.umich.edu/event/83750 83750-21485477@events.umich.edu Event Begins: Wednesday, April 21, 2021 10:30am
Location: Off Campus Location
Organized By: Biomedical Engineering

Dopamine regulates motor performance and learning. Current models suggest that dopamine signals reward-prediction errors and/or movement vigor. These functions have been assessed predominantly using simple behavioral tasks. The role of dopamine in dexterous skill, however, is unknown. This question is important to understanding motor disorders such as Parkinson's Disease. Here we describe an experimental model to interrogate the role of dopamine release during learning and performance of dexterous skill. Fluorescent sensors dLight1.1 and GCaMP are used to monitor dopamine and calcium activity in the striatum and substantia nigra pars compacta (SNc) in rats performing skilled reaching tasks. Preliminary experiments have successfully recorded reward-associated signals in both striatum and SNc. Adaptations to the recording setup to facilitate long-term recording in larger rodents are described. These results demonstrate the viability of fiber photometry for measuring dopamine-related activity during skilled reaching tasks.



Date: Wednesday April 21, 2021

Time: 10:30 AM

Zoom: https://umich.zoom.us/j/96449273959

Chair: Dr. Dan Leventhal

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Lecture / Discussion Tue, 13 Apr 2021 15:34:29 -0400 2021-04-21T10:30:00-04:00 2021-04-21T11:30:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Special Joint Seminar between DCMB, Mathematics, MIDAS, and Smale Institute (April 22, 2021 1:00pm) https://events.umich.edu/event/83615 83615-21491327@events.umich.edu Event Begins: Thursday, April 22, 2021 1:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

The quest to understand consciousness, once the purview of philosophers and theologians, is now actively pursued by scientists of many stripes. This talk looks at consciousness from the perspective of theoretical computer science. It formalizes the Global Workspace Theory (GWT) originated by cognitive neuroscientist Bernard Baars and further developed by him, Stanislas Dehaene, and others. Our major contribution lies in the precise formal definition of a Conscious Turing Machine (CTM), also called a Conscious AI. We define the CTM in the spirit of Alan Turing’s simple yet powerful definition of a computer, the Turing Machine (TM). We are not looking for a complex model of the brain nor of cognition but for a simple model of (the admittedly complex concept of) consciousness. After formally defining CTM, we give a formal definition of consciousness in CTM. We then suggest why the CTM has the feeling of consciousness. The reasonableness of the definitions and explanations can be judged by how well they agree with commonly accepted intuitive concepts of human consciousness, the range of related concepts that the model explains easily and naturally, and the extent of its agreement with scientific evidence.

https://umich.zoom.us/j/95135773568

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Livestream / Virtual Wed, 14 Apr 2021 10:17:45 -0400 2021-04-22T13:00:00-04:00 2021-04-22T14:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual
Links Between Culture and Sanitation (April 22, 2021 5:00pm) https://events.umich.edu/event/83816 83816-21540179@events.umich.edu Event Begins: Thursday, April 22, 2021 5:00pm
Location: Off Campus Location
Organized By: Project RISHI

Dr. Balmurli Natrajan, Professor of Anthropology at William Paterson University will speak on the social practices in communities where open defecation is prevalent, toilet use, and sanitation practices in India. The discussion will center around the link between culture and accepting modern adaptations in rural communities. RSVP Here: https://docs.google.com/forms/d/e/1FAIpQLSdaJwRFl1WH56j3j604SnuPiLF5vRvgiAHais0Hse4ISjAATA/viewform

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Conference / Symposium Tue, 20 Apr 2021 14:07:20 -0400 2021-04-22T17:00:00-04:00 2021-04-22T18:00:00-04:00 Off Campus Location Project RISHI Conference / Symposium Dr. Balmurli Natrajan, Professor of Anthropology at William Paterson University
20th Annual James V. Neel Lectureship (April 23, 2021 11:00am) https://events.umich.edu/event/83872 83872-21561727@events.umich.edu Event Begins: Friday, April 23, 2021 11:00am
Location: Off Campus Location
Organized By: Department of Human Genetics

DEPARTMENT OF HUMAN GENETICS - 20TH ANNUAL JAMES V. NEEL LECTURESHIP

“Remembrance of Things Past: Reactivation of Fetal Hemoglobin for Therapy.”

Presented by:
Stuart H. Orkin, M.D.
David G. Nathan Distinguished Professor of Pediatrics
Investigator, Howard Hughes Medical Institute
Harvard Medical School

FRIDAY, MAY 7, 2021
12:00PM - 3:00PM EST
Zoom Meeting ID: 983 1136 4189
Zoom Meeting Link: https://umich.zoom.us/j/98311364189

Sponsored by:
The Department of Human Genetics
University of Michigan Medical School
Event Website: https://medicine.umich.edu/dept/human-genetics/events/202105/20th-annual-james-v-neel-lectureship

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Lecture / Discussion Fri, 23 Apr 2021 11:02:42 -0400 2021-04-23T11:00:00-04:00 2021-04-23T12:00:00-04:00 Off Campus Location Department of Human Genetics Lecture / Discussion 2021 JAMES V. NEEL LECTURESHIP FLYER
Master's Defense: Ivo Cerda (April 30, 2021 10:00am) https://events.umich.edu/event/83915 83915-21612995@events.umich.edu Event Begins: Friday, April 30, 2021 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

Co-registering, chronic, and naturalistic assessments of the electrophysiological and behavioral features of the murine stress response can teach us how stress-behaviors are mechanistically driven by electrophysiological activity in neural circuits, how those relationships change over the course of the multi-week developing response to chronic ongoing stress, and how these changes ultimately contribute to the pathogenesis and progression of major depressive disorder and other psychiatric conditions. However, the long duration and multiplexed nature of the murine stress response have long been barriers to achieving such understandings. To address the need for technology that better captures the time progression of the murine stress response, we engineered the first-ever chronic recording system capable of gathering both behavioral and electrophysiological data in a naturalistic environment for freely-moving mice. Building from previous unpublished work at our lab, we first developed 16 units of a novel photointerrupter-based, Arduino-controlled digital phenotyping system capable of simultaneously recording 50+ behavioral metrics at a sub-second resolution continuously for weeks at a time. Subsequently, with the goal of assisting the concurrent exploration of brain mechanisms and behavior, we engineered a scaffold and cabling structure to support an ultra low-resistance commutator that allows chronic, multi-region brain electrophysiological recordings and integrated it into our digital behavioral phenotyping system. Our novel co-recording system is now fully operational and, along with allowing chronic electrophysiological recordings, supports measures of eating, drinking, food and sugary drink preference (a measure of anhedonia), locomotor activity, sleep, and actigraphy, all the while using 24/7 video tracking to allow detailed classification of behaviors at sub-second resolution. The system is also compatible with standard assessments in the field, including daily weight and fur checks. To demonstrate the duration of its co-recording capabilities, we implanted a cohort of mice with electrodes in three brain regions involved in the murine stress response – olfactory bulb, dorsal hippocampus, and medial prefrontal cortex – and recorded for five weeks. This is the first system to ever produce highly dense behavioral and electrophysiological data simultaneously and continuously over such a period of time.


Details:
DATE: Friday, April 30, 2021
TIME: 10:00 am - 12:00 pm
LOCATION: Zoom https://umich.zoom.us/j/93571968494)
Chair Committee: Brendon Watson, Tim Bruns, Cindy Chestek

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Lecture / Discussion Thu, 29 Apr 2021 20:12:17 -0400 2021-04-30T10:00:00-04:00 2021-04-30T12:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
BME Commencement 2021 (May 1, 2021 3:30pm) https://events.umich.edu/event/83890 83890-21595415@events.umich.edu Event Begins: Saturday, May 1, 2021 3:30pm
Location: Off Campus Location
Organized By: Biomedical Engineering

PLEASE MAKE SURE TO RSVP WITH THE LINK!

BME COMMENCEMENT CEREMONY
SATURDAY, MAY 1, 2021 | 3:30 PM EDT


COMMENCEMENT CEREMONY
ZOOM @ (3:30 PM)

AFTER PARTY
Spatial Chat @ (~4:30 PM)
(AFTER THE CEREMONY)

PROGRAM
Welcome & Introduction | Lonnie Shea Ph.D.
Program Chair Remarks | Rachael Schmedlen, Ph.D., Jan Stegemann, Ph.D., & Tim Bruns, Ph.D.
Program Coordinator Remarks | Rachel Patterson & Maria Steele
Alumni Welcome and Congratulations | Scott Merz, Richard Youngblood, & Xiaotian Tan
Student Addresses | Dipra Debnath, Ivo Woldarsky, & Katy Norman
Announcing the Graduates | Melissa Wrobel Ph.D., Brendon Baker, Ph.D., James Weiland, Ph.D., & Tim Bruns, Ph.D.
Confirmation of Degrees | Lonnie Shea, Ph.D.
Congratulations and Closing | Lonnie Shea, Ph.D.
Virtual socializing & After Party | Come congratulate and socialize with your fellow graduates, families, professors, and friends following the BME Commencement Ceremony.

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Ceremony / Service Tue, 27 Apr 2021 15:09:45 -0400 2021-05-01T15:30:00-04:00 Off Campus Location Biomedical Engineering Ceremony / Service BME Logo
RNA Seminar featuring: Olivia Rissland, University of Colorado School of Medicine (May 3, 2021 4:00pm) https://events.umich.edu/event/81302 81302-20881902@events.umich.edu Event Begins: Monday, May 3, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

Registration Required: https://umich.zoom.us/webinar/register/WN_vA9zYS5nSEenf8Zmt1f-qA


ABSTRACT: The maternal-to-zygotic transition (MZT) is a conserved step in animal development, where control is passed from the maternal to the zygotic genome. Although the MZT is typically considered from its impact on the transcriptome, we previously found that three maternally deposited Drosophila RNA binding proteins (ME31B, Trailer Hitch [TRAL], and Cup) are also cleared during the MZT by unknown mechanisms. Here, we show that these proteins are degraded by the ubiquitin-proteasome system. Marie Kondo, an E2 conjugating enzyme, and the E3 CTLH ligase are required for the destruction of ME31B, TRAL, and Cup. Structure modeling of the Drosophila CTLH complex suggests that substrate recognition is different than orthologous complexes. Despite occurring hours earlier, egg activation mediates clearance of these proteins through the Pan Gu kinase, which stimulates translation of Kondo mRNA. Clearance of the maternal protein dowry thus appears to be a coordinated, but as-yet underappreciated, aspect of the MZT.

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Lecture / Discussion Fri, 02 Apr 2021 16:07:11 -0400 2021-05-03T16:00:00-04:00 2021-05-03T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Olivia Rissland, Ph.D.
PhD Defense: Jonas Schollenberger (May 4, 2021 3:00pm) https://events.umich.edu/event/83855 83855-21555868@events.umich.edu Event Begins: Tuesday, May 4, 2021 3:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Cerebrovascular occlusive disease (CVOD) is a major risk factor for ischemic stroke and is characterized by the presence of stenosis in the arteries supplying the brain. The cerebral vasculature has an innate ability to compensate for flow reductions, caused by the presence of CVOD, through a network of collateral pathways in the circle of Willis (CoW). However, flow compensation is highly patient-specific and dependent on the cerebral vasculature anatomy, availability of collateral pathways, degree of stenosis and, the condition of the cerebral microcirculation and its autoregulatory response. Unfortunately, clinically available imaging tools only provide limited information on flow compensation and the underlying cerebral hemodynamics. Given the complexity of the cerebral vasculature, better tools are necessary to characterize cerebral hemodynamics and guide the risk assessment of ischemic stroke.



Image-based computational fluid dynamics (CFD) provides a powerful tool for non-invasively analyzing cerebral hemodynamics with high spatial and temporal resolutions. However, CFD modeling of cerebral hemodynamics is challenging due to the need for patient-specific data to calibrate outflow boundary conditions in the brain. In this thesis, we explore a novel strategy to quantitatively characterize cerebral hemodynamics using CFD in combination with tissue perfusion from arterial spin labeling (ASL) MRI.



Firstly, we quantified territorial perfusion in the cerebral circulation through implementing and optimizing a vessel-selective arterial spin labeling (VS-ASL) sequence. VS-ASL is generally limited by its low labeling efficiency causing poor signal-to-noise ratio. We investigated the effects of off‐resonance, pulsatility, and vessel movement, and evaluated methods to maximize labeling efficiency and overall image quality. We found that an off-resonance calibration scan in combination with cardiac-triggering significantly improved labeling efficiency and image quality. Vessel movement during the MRI protocol occurred in the majority of study subjects and needs to be accounted for to maximize labeling efficiency.



Secondly, we developed a strategy to calibrate patient-specific CFD models of cerebral blood flow. The calibration consisted of estimating the total inflow to the CoW from PC-MRI and the flow splits in the CoW from non-selective ASL perfusion images. The outflow boundary conditions were iteratively tuned to match the estimated flow splits, and the ASL-calibrated CFD model was then validated against territorial perfusion maps from VS-ASL by calculating the blood supply to each cerebral territory using Lagrangian particle tracking (LPT). We found an overall good match in a small group of subjects; particularly, the flow compensation between hemispheres was captured well by the calibrated CFD models.



Thirdly, we investigated the impact of two outflow boundary condition strategies, an ASL-based and allometric-based calibration, on cerebral hemodynamics. The ASL-based calibrated CFD analysis captured the flow compensation between hemispheres as measured with VS-ASL and lead to an approximately symmetrical flow distribution in the CoW. In contrast, the allometric-based calibrated CFD analysis was unable to capture the collateral flow compensation, which resulted in large differences in flow between hemispheres.



Finally, the clinical feasibility and capabilities of our proposed CFD analysis was demonstrated in two CVOD patients. The CFD analysis showed significant differences in cerebral hemodynamics between the patients despite similar degrees of stenosis severity, highlighting the importance of a patient-specific assessment. Comparison of pre-operative and post-operative hemodynamics in one patient resulted in only minor changes following revascularization despite severe carotid stenosis. We demonstrated that our CFD analysis can provide detailed and quantitative information about hemodynamic impact of carotid stenosis and collateral flow compensation in the circle of Willis.


Date: Tuesday, May 4, 2021

Time: 3:00 PM

Zoom: https://umich.zoom.us/j/93059726229 (Zoom link requires prior registration)

Co-Chairs: Dr. C. Alberto Figueroa and Dr. Luis Hernandez-Garcia

For Assistance or Questions
um-bme@umich.edu

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Lecture / Discussion Thu, 22 Apr 2021 13:33:46 -0400 2021-05-04T15:00:00-04:00 2021-05-04T16:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Bugs as Drugs: Engineering Bacterial Biotherapeutics (May 5, 2021 9:00am) https://events.umich.edu/event/83930 83930-21619144@events.umich.edu Event Begins: Wednesday, May 5, 2021 9:00am
Location: Off Campus Location
Organized By: Michigan Microbiome Project

ABSTRACT

The human body is a complex ecosystem supporting symbiotic relationships with thousands of microbial species. The ubiquity and importance of these commensal communities underscore their potential as an untapped reservoir of biological function, and recent increased interest into commensal microbial species has led to countless insights in this field. Due to these efforts, the opportunity now exists to capitalize on the increasingly sophisticated understanding of the human microbiota and expand research efforts beyond characterization, toward engineering. Commensal microbes are already perfectly suited for safe and effective habitation and colonization of various physiological niches; what remains is to harness their genomic plasticity and promote their capacity to function as robust biochemical factories. The Sirk Lab aims to engineer therapeutic capacity into commensal microorganisms to address unmet needs in human health, with a specific focus on generating strains of human gut bacterial species that can produce disease-fighting biological compounds in the intestinal tract to address key limitations with current therapeutic approaches for important diseases such as recurrent gastrointestinal infections. We are also pursuing studies focused on respiratory disease in both humans and animals of agricultural relevance.



BIO

Prof. Sirk received her AB in Biology from Occidental College in Los Angeles, CA and her Ph.D. in Molecular and Medical Pharmacology from UCLA. Her doctoral studies focused on engineering antibody fragments for targeted tumor imaging using positron emission tomography. Her postdoctoral training began at The Scripps Research Institute in La Jolla, CA, where she continued to work with engineered antibodies while also performing detailed protein engineering studies to generate site-specific nucleases and recombinases for targeted genome modifications, in the era immediately prior to the introduction of CRISPR-based gene editing technology. She then pursued further postdoctoral training at Stanford University where she first began to explore the world of commensal microbes by studying the role that gut bacteria play in the activation of drug-like dietary molecules. At the University of Illinois, her research group aims to leverage the power of protein engineering, therapeutic biomolecules, and the ever-expanding opportunities of commensal microbial species and communities to address critical needs in disease prevention and treatment in humans, animals, insects, and plants.

HOSTS:
Matthew Ostrowski
Thomas Schmidt

https://umich.zoom.us/j/96357036922

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Workshop / Seminar Fri, 30 Apr 2021 12:26:40 -0400 2021-05-05T09:00:00-04:00 2021-05-05T10:00:00-04:00 Off Campus Location Michigan Microbiome Project Workshop / Seminar MMP logo
PhD Defense: Elissa Welle (May 7, 2021 10:00am) https://events.umich.edu/event/83883 83883-21587612@events.umich.edu Event Begins: Friday, May 7, 2021 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

Neural interfaces create a connection between neural structures in the body and external electronic devices. Brain-machine interfaces and bioelectric medicine therapies rely on the seamless integration of neural interfaces with the brain, nerves, or spinal cord. However, conventional neural interfaces cannot meet the demands of high channel count, signal fidelity, and signal longevity that these applications require.



In this thesis we characterized the damage resulting from conventional Utah arrays after multiple years of implantation in the cortex of a non-human primate. The neuron density around the electrode shanks was compared to the neuron density of nearby healthy tissue, finding a 73% loss in density around the electrodes. The explanted arrays were imaged and characterized for forms of electrode surface inconsistency. Coating cracks, tip breakage, and parylene cracks were the most common inconsistency. A significantly higher number of tip breakage and coating crack occurrences were found on the edges of the arrays as compared to the middle. In this work, we made clear the need for a minimally damaging alternative to the Utah electrode array.



Neural interfaces composed of carbon fiber electrodes, with a diameter of 6.8 microns, could enable a more seamless integration with the body. Previous work resulted in an array of individuated carbon fiber electrodes that could record reliably high signal-to-noise ratio neural signals from the brain for several months. However, the carbon fiber arrays were limited by only 30% of the electrodes recording neural signals, despite inducing very minimal inflammation. Additionally, it was relatively unknown if carbon fibers would make suitable long-term peripheral neural interfaces. Here, we illustrate the potential of carbon fiber electrodes to meet the needs of a variety of neural applications.



First, we optimized state-of-the-art carbon fiber electrodes to reliably record single unit electrophysiology from the brain. By analyzing the previous manufacturing process, the cause of the low recording yield of the carbon fiber arrays was identified as the consistency of the electrode tip. A novel laser cutting technique was developed to produce a consistent carbon fiber tip geometry, resulting in a near tripling of recording yield of high amplitude chronic neural signals. The longevity of the carbon fiber arrays was also addressed. The conventional polymer coating was compared against platinum iridium coating and an oxygen plasma treatment, both of which outperformed the polymer coating. In this work, we customized carbon fiber electrodes for reliable, long-term neural recording.



Secondly, we translated the carbon fiber technology from the brain to the periphery in an architecture appropriate for chronic implantation. The insertion of carbon fibers into the stiffer structures in the periphery is enabled by sharpening the carbon fibers. The sharpening process combines a butane flame to sharpen the fibers with a water bath to protect the base of the array. Sharpened carbon fibers recorded electrophysiology from the rat vagus nerve and feline dorsal root ganglia, both structures being important targets for bioelectric medicine therapies. The durability of carbon fibers was also displayed when partially embedded carbon fibers in medical-grade silicone withstood thousands of repeated bends without fracture. This work showed that carbon fibers have the electrical and structural properties necessary for chronic application.



Overall, this work highlights the vast potential of carbon fiber electrodes. Through this thesis, future brain-machine interfaces and bioelectric medicine therapies may utilize sub-cellular electrodes such as carbon fibers in medical applications.



Date: Friday, May 7, 2021

Time: 10:00 AM

Zoom: https://umich.zoom.us/j/95839545566 (Zoom link requires prior registration)

Chair: Dr. Cynthia Chestek

For Assistance or Questions
um-bme@umich.edu

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Lecture / Discussion Mon, 26 Apr 2021 17:03:39 -0400 2021-05-07T10:00:00-04:00 2021-05-07T11:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
2021 BME Symposium (May 10, 2021 12:00pm) https://events.umich.edu/event/82858 82858-21203302@events.umich.edu Event Begins: Monday, May 10, 2021 12:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

To register please see:
https://myumi.ch/r8GzZ

The 2021 BME symposium will showcase our work in the areas of Imaging, Neural Engineering, Regenerative Medicine, and Precision Health. The event will take place over two days in the afternoons of Monday, May 10, 12:00 PM - 5:00 PM, and Tuesday, May 11, 12:00 PM - 5:00 PM. Each afternoon will include faculty talks, mini student dissertations, a panel discussion, and student poster sessions.

The goal of this event is to bring together faculty and students affiliated with BME from all parts of campus as a step toward building the BME community and celebrating accomplishments through difficult times while having an eye toward the future.

Please sign up and join us!

2021 U-M BME Symposium



May 10, 2021: 12:00 PM - 5:00 PM


Imaging at UM

May 10, 2021 - 12:00pm - 1:30pm
Location: Virtual/Zoom
Livestream Available (Visible After Registration)

Moderator: Doug Noll
12:00 - 12:15 - Zhongming Liu, “Preclinical MRI of brain-gut interactions”
12:15 - 12:30 - Nicole Seiberlich, “Translating Quantitative MRI to the Clinic”
12:30 - 12:45 - Yannis Paulus, “Multimodal Photoacoustic Microscopy, OCT, and Fluorescence Molecular and Cellular Imaging of the Retina”
12:45 - 1:05 - Student Dissertations
1:05 - 1:30 - Panel Discussion - “The Future of Imaging Research at Michigan” - Vikas Gulani, Jeff Fessler, Cheri Deng, Zhen Xu, Xueding Wang


Neural Engineering at UM

May 10, 2021 - 2:00pm - 3:30pm
Location: Virtual/Zoom
Livestream Available (Visible After Registration)

Moderator: Jim Weiland
2:00 - 2:15 - Kamran Diba, TBD
2:15 - 2:30 - Scott Lempka, TBD
2:30 - 2:45 - Deanna Gates, TBD
2:45 - 3:05 - Student Dissertations
3:05 - 3.30 - Panel Discussion - “The Science Fiction Future of Neural Engineering” - Cindy Chestek, Parag Patil, Tim Bruns, Bill Stacey


Poster Session: Imaging & Neural Engineering

May 10, 2021 - 4:00pm - 5:00pm
Location: Virtual/Spatial Chat

This poster session will give BME students a chance to present and discuss their research in the areas of Imaging and Neural Engineering.


May 11, 2021: 12:00 PM - 5:00 PM


Regenerative Medicine at UM

May 11, 2021 - 12:00pm - 1:30pm
Location: Virtual/Zoom
Livestream Available (Visible After Registration)

Moderator: Lonnie Shea
12:00 - 12:15 - Carlos Aguilar, ”Understanding & Re-Writing Stem Cell Programs to Live Forever.”
12:15 - 12:30 - Idse Heemskerk, “Predicting cell fate from signaling history in human pluripotent stem cells”
12:30 - 12:45 - Ariella Shikanov, TBD
12:45 - 1:05 - Student Dissertations
1:05 - 1:30 - Panel Discussion - "Grand Challenges in Regenerative Medicine" - Dave Kohn


Precision Health at UM

May 11, 2021 - 2:00pm - 3:30pm
Location: Virtual/Zoom
Livestream Available (Visible After Registration)

Moderator: TBD
2:00 - 2:15 - Sriram Chandrasekharan, TBD
2:15 - 2: 30 - James Moon, TBD
2:30 - 2:45 - Deepak Nagrath, TBD
2:45 - 3:05 - Student Dissertations
3:05 - 3:30 - Panel Discussion - "Hope or Hype for Treating Diseases" - James Moon, Sriram Chandrasekharan, Deepak Nagrath



Poster Session: Regenerative Medicine & Precision Health


May 11, 2021 - 4:00pm - 5:00pm
Location: Virtual/Spatial Chat


This poster session will give BME students a chance to present and discuss their research in the areas of Regenerative Medicine and Precision Health.

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Conference / Symposium Thu, 22 Apr 2021 13:38:37 -0400 2021-05-10T12:00:00-04:00 2021-05-10T17:00:00-04:00 Off Campus Location Biomedical Engineering Conference / Symposium BME Logo
2021 BME Symposium (May 11, 2021 12:00pm) https://events.umich.edu/event/82858 82858-21555869@events.umich.edu Event Begins: Tuesday, May 11, 2021 12:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

To register please see:
https://myumi.ch/r8GzZ

The 2021 BME symposium will showcase our work in the areas of Imaging, Neural Engineering, Regenerative Medicine, and Precision Health. The event will take place over two days in the afternoons of Monday, May 10, 12:00 PM - 5:00 PM, and Tuesday, May 11, 12:00 PM - 5:00 PM. Each afternoon will include faculty talks, mini student dissertations, a panel discussion, and student poster sessions.

The goal of this event is to bring together faculty and students affiliated with BME from all parts of campus as a step toward building the BME community and celebrating accomplishments through difficult times while having an eye toward the future.

Please sign up and join us!

2021 U-M BME Symposium



May 10, 2021: 12:00 PM - 5:00 PM


Imaging at UM

May 10, 2021 - 12:00pm - 1:30pm
Location: Virtual/Zoom
Livestream Available (Visible After Registration)

Moderator: Doug Noll
12:00 - 12:15 - Zhongming Liu, “Preclinical MRI of brain-gut interactions”
12:15 - 12:30 - Nicole Seiberlich, “Translating Quantitative MRI to the Clinic”
12:30 - 12:45 - Yannis Paulus, “Multimodal Photoacoustic Microscopy, OCT, and Fluorescence Molecular and Cellular Imaging of the Retina”
12:45 - 1:05 - Student Dissertations
1:05 - 1:30 - Panel Discussion - “The Future of Imaging Research at Michigan” - Vikas Gulani, Jeff Fessler, Cheri Deng, Zhen Xu, Xueding Wang


Neural Engineering at UM

May 10, 2021 - 2:00pm - 3:30pm
Location: Virtual/Zoom
Livestream Available (Visible After Registration)

Moderator: Jim Weiland
2:00 - 2:15 - Kamran Diba, TBD
2:15 - 2:30 - Scott Lempka, TBD
2:30 - 2:45 - Deanna Gates, TBD
2:45 - 3:05 - Student Dissertations
3:05 - 3.30 - Panel Discussion - “The Science Fiction Future of Neural Engineering” - Cindy Chestek, Parag Patil, Tim Bruns, Bill Stacey


Poster Session: Imaging & Neural Engineering

May 10, 2021 - 4:00pm - 5:00pm
Location: Virtual/Spatial Chat

This poster session will give BME students a chance to present and discuss their research in the areas of Imaging and Neural Engineering.


May 11, 2021: 12:00 PM - 5:00 PM


Regenerative Medicine at UM

May 11, 2021 - 12:00pm - 1:30pm
Location: Virtual/Zoom
Livestream Available (Visible After Registration)

Moderator: Lonnie Shea
12:00 - 12:15 - Carlos Aguilar, ”Understanding & Re-Writing Stem Cell Programs to Live Forever.”
12:15 - 12:30 - Idse Heemskerk, “Predicting cell fate from signaling history in human pluripotent stem cells”
12:30 - 12:45 - Ariella Shikanov, TBD
12:45 - 1:05 - Student Dissertations
1:05 - 1:30 - Panel Discussion - "Grand Challenges in Regenerative Medicine" - Dave Kohn


Precision Health at UM

May 11, 2021 - 2:00pm - 3:30pm
Location: Virtual/Zoom
Livestream Available (Visible After Registration)

Moderator: TBD
2:00 - 2:15 - Sriram Chandrasekharan, TBD
2:15 - 2: 30 - James Moon, TBD
2:30 - 2:45 - Deepak Nagrath, TBD
2:45 - 3:05 - Student Dissertations
3:05 - 3:30 - Panel Discussion - "Hope or Hype for Treating Diseases" - James Moon, Sriram Chandrasekharan, Deepak Nagrath



Poster Session: Regenerative Medicine & Precision Health


May 11, 2021 - 4:00pm - 5:00pm
Location: Virtual/Spatial Chat


This poster session will give BME students a chance to present and discuss their research in the areas of Regenerative Medicine and Precision Health.

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Conference / Symposium Thu, 22 Apr 2021 13:38:37 -0400 2021-05-11T12:00:00-04:00 2021-05-11T17:00:00-04:00 Off Campus Location Biomedical Engineering Conference / Symposium BME Logo
Connecting Education Innovation to Activism (May 12, 2021 12:00pm) https://events.umich.edu/event/83807 83807-21538170@events.umich.edu Event Begins: Wednesday, May 12, 2021 12:00pm
Location: Off Campus Location
Organized By: RISE (Research. Innovation. Scholarship. Education.)

R.I.S.E., the Center for Academic Innovation, and the Center for Research on Learning & Teaching (CRLT) invite you to join a Virtual Talking Circle (VTC) to discuss unique connections between education innovation & activism.

This collaboration across the University will serve as a first step in building a community interested in designing and promoting education innovation to improve society.

Anyone interested in education innovation and/or social justice and activism is invited!  We want to learn who is already doing this important work and identify potential collaborations across the University.

Please join us on Wednesday, May 12, 2021 from 12:00 - 1:00 PM

Register via Eventbrite

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Workshop / Seminar Tue, 20 Apr 2021 06:37:52 -0400 2021-05-12T12:00:00-04:00 2021-05-12T13:00:00-04:00 Off Campus Location RISE (Research. Innovation. Scholarship. Education.) Workshop / Seminar RISE Virtual Talking Circle
RNA Seminar featuring: Thomas Martinez, Salk Institute for Biological Studies (May 17, 2021 4:00pm) https://events.umich.edu/event/81303 81303-20881903@events.umich.edu Event Begins: Monday, May 17, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

Registration Required: https://umich.zoom.us/webinar/register/WN_90RkcQTGQZa7ifQ8kbSdNQ

KEYOWORDS: microprotein, smORF, ribosome profiling

ABSTRACT: Functional protein-coding small open reading frames (smORFs) are emerging as an important class of genes. Several smORF-encoded microproteins have been characterized and implicated in a variety of critical processes, including regulation of mRNA decay, DNA repair, and muscle formation. Thus, rigorous and comprehensive annotation of protein-coding smORFs is critical to our understanding of basic biology and physiology, as well as disease. We recently developed an improved workflow that integrates de novo transcriptome assembly and ribosome profiling to overcome obstacles with previous methods to more confidently annotate thousands of novel smORFs across multiple human cell lines, including hundreds encoded on putative non-coding RNAs. Over 1,500 smORFs are found in two or more cell lines, and ~40% lack a canonical AUG start codon. Evolutionary conservation analyses suggest that hundreds of smORF-encoded microproteins are likely functional. We also find that smORF-derived peptides are detectable on human leukocyte antigen complexes, positioning smORFs as a source of novel antigens. The annotation of protein-coding smORFs radically alters the current view of the human genome’s coding capacity and will provide a rich pool of unexplored, functional human genes.

BIO: Thomas received his B.S. in Biological Engineering from MIT and trained in Prof. JoAnne Stubbe’s laboratory, where he studied the mechanism of ribonucleotide reductase. He then recieved his Ph.D. in Biochemistry & Molecular Biophysics from Caltech as an NIH NRSA predoctoral fellow under the mentorship of Prof. Peter Dervan. His thesis work focused primarily on characterizing the effects of DNA binding pyrrole-imidazole polyamides on DNA replication in prostate cancer cells. Thomas is currently an NIH NRSA postdoctoral fellow in Prof. Alan Saghatelian’s laboratory, where he has developed an integrative platform combining ribosome profiling and de novo transcriptome assembly to discover functional smORF encoded microproteins in the human genome.

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Lecture / Discussion Wed, 14 Apr 2021 12:39:54 -0400 2021-05-17T16:00:00-04:00 2021-05-17T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Thomas Martinez, Salk Institute for Biological Studies
Microbiome Seminar: Developing and Applying a Microdroplet Co-Cultivation and Analysis Toolbox for Elucidating Microbiomes (May 19, 2021 9:00am) https://events.umich.edu/event/84064 84064-21619785@events.umich.edu Event Begins: Wednesday, May 19, 2021 9:00am
Location: Off Campus Location
Organized By: Michigan Microbiome Project

Speaker: Xiaoxia (Nina) Lin
Associate Professor, Dept. Chemical Engineering

Speaker Profile: Professor Lin’s research lies at the intersection of biology and engineering with a focus on microbial systems, particularly microbial communities, using systems biology and synthetic biology approaches. Her lab aims to employ engineering tools and skills such as microfluidics and quantitative modeling to help unlock mysteries of complex natural microbial communities, especially those closely associated with environment and health issues (e.g. human microbiome). In parallel, the research group exploits design principles nature utilizes and develops synthetic microbial consortia technologies to address critical needs faced by our society such as sustainable biofuel and chemical production.

Abstract: Microbes are everywhere in nature and they live in diverse communities that show remarkable metabolic capabilities and robustness. One research thrust in my lab has been to employ engineering related tools to study these naturally occurring microbial consortia in order to discover underlying cellular and molecular mechanisms. In particular, we have been developing a technological pipeline, based on nanoliter-scale microfluidic droplets, to co-cultivate sub-communities and characterize member interactions that shape the community structure and function. In this talk, I will present a number of technological modules we have created and are developing. I’ll also discuss how we are applying this toolbox, jointly with our collaborators, to the investigation of several microbiomes closely related to human health or the environment.

Zoom Meeting: https://umich.zoom.us/j/92773919973

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Workshop / Seminar Mon, 17 May 2021 14:12:26 -0400 2021-05-19T09:00:00-04:00 2021-05-19T10:00:00-04:00 Off Campus Location Michigan Microbiome Project Workshop / Seminar Michigan Microbiome Project
Seminar: Lindsay M. LaFave, Ph.D., Massachusetts Institute of Technology and Harvard University (May 24, 2021 3:00pm) https://events.umich.edu/event/84070 84070-21619805@events.umich.edu Event Begins: Monday, May 24, 2021 3:00pm
Location: Off Campus Location
Organized By: Life Sciences Institute (LSI)

Abstract:
A key feature of cancer development is the loss of gene regulatory programs that govern normal cellular identity; however, these disrupted regulatory landscapes, or epigenomic states, are not well understood. To study epigenomic state changes in the natural evolution of lung adenocarcinoma (LUAD), I utilized the well-established KrasG12D/+p53-/- (KP) murine model of LUAD progression. Using an optimized single-cell ATAC-sequencing approach with combinatorial indexing, I profiled the chromatin accessibility states of individual KP tumors, metastases, and normal lungs. Strikingly, we identified expansive epigenomic heterogeneity across cancer progression; yet, these cell states followed reproducible trajectories across individual tumors—suggesting conserved paths toward metastasis. We utilized computational tools to identify 11 discernable states across LUAD cancer progression characterized by transcription factor (TF) regulators and downstream regulated genes. These analyses led to the identification of a late-stage program associated with progressive RUNX2 activation and adverse survival in human patients. Together, these results demonstrated the utility of single-cell epigenomics to identify TF-driven regulatory programs as key biomarkers of cancer progression. My ongoing work leverages evolving epigenomic technologies in murine and organoid systems to understand the overarching mechanisms dictating altered chromatin state in cancer.

Speaker:
Lindsay M. LaFave is a cancer biologist with a long-standing interest in studying chromatin biology. Lindsay completed her B.S. in biochemistry at the University of Michigan in 2009. She received her Ph.D. in Cancer Biology at Gerstner Sloan Kettering Graduate School in New York City in 2015. Her graduate research in Ross Levine’s lab at Memorial Sloan Kettering Cancer Center focused on studying the role of mutated chromatin modifying proteins in hematopoietic malignancies. For her postdoctoral training, she continued to study epigenetic mechanisms of cancer progression, shifting her primary focus to solid tumors. Lindsay is a current Damon Runyon postdoctoral fellow in the labs of Tyler Jacks at MIT and Jason Buenrostro at Harvard University. Her work leverages murine modeling and single-cell epigenomic technologies to understand cell state changes that occur during cancer progression in lung adenocarcinoma. During her postdoctoral training, Lindsay identified a diverse repertoire of gene regulatory changes important in cancer progression that were associated with altered cellular identity and the emergence of pre-metastatic gene programs. Her independent research group will utilize evolving epigenomic technologies and cancer models to dissect chromatin-mediated mechanisms driving lung cancer.

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Lecture / Discussion Tue, 18 May 2021 10:45:17 -0400 2021-05-24T15:00:00-04:00 2021-05-24T16:00:00-04:00 Off Campus Location Life Sciences Institute (LSI) Lecture / Discussion
PhD Defense: Edward Peter Washabaugh IV (May 27, 2021 10:00am) https://events.umich.edu/event/84050 84050-21619709@events.umich.edu Event Begins: Thursday, May 27, 2021 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

Injuries to the neuromusculoskeletal systems often result in muscle weakness, abnormal coordination strategies, and gait impairments. Functional resistance training during walking—where a patient walks while a device increases loading on the leg—is an emerging approach to combat these symptoms. While simple passive devices (i.e., ankle weights and resistance bands) can be applied for this training, rehabilitation robots have more potential upside because they can be controlled to treat multiple gait abnormalities and can be monitored by clinicians. However, the cost of conventional robotic devices limits their use in the clinical or home setting. Hence, in this dissertation, we designed, developed, and tested passive and semi-passive wearable exoskeleton devices as a low-cost solution for providing controllable/configurable functional resistance training during walking.


We developed and tested two passive exoskeleton devices for providing resistance to walking and tested their effects on able-bodied participants and stroke survivors. First, we created a patented device that used a passive magnetic brake to provide a viscous (i.e., velocity-dependent) resistance to the knee. The resistive properties of the device could be placed under computer control (i.e., made semi-passive) to control resistance in real-time. Next, we created a passive exoskeleton that provided an elastic (i.e., position-dependent) resistance. While not controllable, this device was highly configurable. Meaning it could be used to provide resistance to joint flexion, extension, or to both (i.e., bidirectionally). Human subjects testing with these devices indicated they increased lower-extremity joint moments, powers, and muscle activation during training. Training also resulted in significant aftereffects—a potential indicator of therapeutic effectiveness—once the resistance was removed. A separate experiment indicated that individuals often kinematically slack (i.e., reduce joint excursions to minimize effort) when resistance is added to the limb. We also found that providing visual feedback of joint angles during training significantly increased muscle activation and kinematic aftereffects (i.e., reduced slacking).


With passive devices, the type of passive element used largely dictates the muscle groups, types of muscle contraction, joint actions, and the phases of gait when a device is able to apply resistance. To examine this issue, we compared the training effects of viscous and elastic devices that provided bidirectional resistance to the knee during gait. Additionally, we compared training with viscous resistances at the hip and knee joints. While the resistance type and targeted joint altered moments, powers, and muscle activation patterns, these methods did not differ in their ability to produce aftereffects, alter neural excitability, or induce fatigue in the leg muscles. While this may indicate that the resistance type does not have a large effect on functional resistance training during walking, it is possible that an extended training with these devices could produce a different result.


Lastly, we used musculoskeletal modeling in OpenSim to directly compare several strategies that have been used to provide functional resistance training to gait in the clinic or laboratory setting. We found that devices differed in their ability to alter gait parameters during walking. Hence, these findings could help clinicians when selecting a resistive strategy for their patients, or engineers when designing new devices or control schemes.



Date: Thursday, May 27, 2021

Time: 10:00 AM

Zoom: https://umich.zoom.us/meeting/register/tJIufumrrDgtHd3z5Jg3Y_BG4ZC70OPrjTjk (Zoom link requires prior registration)

Chair: Dr. Chandramouli Krishnan

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Lecture / Discussion Fri, 14 May 2021 13:49:26 -0400 2021-05-27T10:00:00-04:00 2021-05-27T11:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
PhD Defense: William Y. Wang (June 4, 2021 12:30pm) https://events.umich.edu/event/84102 84102-21620248@events.umich.edu Event Begins: Friday, June 4, 2021 12:30pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Mechanoreciprocity in cell migration is an emerging concept describing the dynamic, bi-directional interactions between migrating cells and the surrounding extracellular matrix (ECM) they negotiate. Migrating cells not only sense and adapt to biochemical and biophysical ECM cues, but also, exert forces, deposit matrix, and secrete chemokines, matrix metalloproteinases, and matrix crosslinking enzymes that dynamically alter the same ECM properties known to regulate cell migration. Due to limitations in standard cell migration assays, how matrix properties influence cell migration and in turn, how cells influence matrix properties, has previously been studied as separate processes. However, observations from development, wound healing, and a variety of disease processes highlight the interdependency and iterative relationship between cell migration and ECM. An improved understanding of the underlying mechanisms that orchestrate the coevolution of migrating cells and ECM will aid in tissue engineering and regenerative medicine efforts to guide repair fibroblasts to regenerate wound beds, direct collective endothelial cell migration to vascularize ischemic or engineered tissue grafts and confine otherwise metastatic cancer cells to the primary tumor. Thus, the focus of this dissertation is to design biomimetic microsystems that afford investigation of cell migration mechanoreciprocity with a focus on fibroblasts, endothelial cells, and cancer cells.



First, this thesis investigated how single mesenchymal cells (fibroblasts and cancer cells) migrate in fibrous stromal tissue settings, such as in trans-stromal cancer cell migration during metastasis. To model fibrous stromal tissue, 3D fiber networks were electrospun over microfabricated wells to define ECM mechanics. Independently tuning alignment and stiffness of these matrices resulted in two phenotypically distinct cell migration modes. In contrast to stiff matrices where cells migrated continuously in a traditional mesenchymal fashion, cells in deformable matrices stretched matrix fibers to store elastic energy; subsequent adhesion failure triggered sudden matrix recoil and rapid cell translocation (termed slingshot migration). Across a variety of cell types, traction force measurements revealed a relationship between cell contractility and the matrix stiffness where slingshot migration mode occurred optimally.



Next, this thesis describes how microenvironmental cues influence collective endothelial cell migration during sprouting angiogenesis towards the design of pro-angiogenic biomaterials. This work employed a multiplexed angiogenesis-on-a-chip platform to assess the chemokine-directed 3D invasion of endothelial cells from a lumenized parent vessel into user-defined ECM. By tuning soluble and physical cues of the ECM, this work identified how 1) functional angiogenesis requires microenvironmental cues that balance cell invasion speed and proliferation; 2) dynamic interactions between sprout stalk cells and ECM regulates neovessel lumenization; and 3) imbuing microporosity within synthetic hydrogels can enhance endothelial cell invasion and angiogenic sprout lumenization.



Lastly, this thesis investigated how fibrous matrix cues activate quiescent vessel-lining endothelial cells into invasive tip cells in the context of fibrosis. Composite hydrogels (electrospun fiber segments suspended within 3D ECM) were integrated with the angiogenesis-on-a-chip platform. These studies establish that heightened matrix fiber density destabilizes cell-cell adherens junctions, reduces endothelium barrier function, and promotes the invasion of endothelial tip cells. Performing transcriptomic and secretomic analyses on fiber-induced tip endothelial cells revealed that fibrous ECM cues promote a fibrosis propagating phenotype.



Overall, the work presented in this dissertation integrates tunable biomaterials with microfabricated devices to investigate cell migration mechanoreciprocity of single mesenchymal cell migration, the collective migration of endothelial cells during angiogenesis, and endothelial-mesenchymal transition of quiescent endothelial cells into a fibrosis propagating cell phenotype.



Date: Friday, June 4, 2021

Time: 12:30 PM

Zoom: https://umich.zoom.us/meeting/register/tJcsf-uhpj4vGtyM7x-td2VV39BzqmF_zoob (Zoom link requires prior registration)

Chair: Dr. Brendon Baker

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Lecture / Discussion Mon, 24 May 2021 14:17:02 -0400 2021-06-04T12:30:00-04:00 2021-06-04T13:30:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Getting Engaged in Campus Education Innovation Activities (June 9, 2021 12:00pm) https://events.umich.edu/event/84084 84084-21619928@events.umich.edu Event Begins: Wednesday, June 9, 2021 12:00pm
Location: Off Campus Location
Organized By: RISE (Research. Innovation. Scholarship. Education.)

Our next Virtual Talking Circle (VTC) will feature representatives from several units on campus that are leading the way in cultivating education innovation: The Center for Academic Innovation (CAI), Fast Forward Medical Innovation (FFMI), and the International Mixed Reality Grand Rounds.

Join us on Wednesday, June 9, 2021 from 12:00 - 1:00 PM to learn more about these units and how you can get involved in their education innovation activities. We hope you will also share other education innovation resources available to faculty, staff and learners.

All are welcome!

Register via Zoom at: https://umich.zoom.us/webinar/register/WN_xVYKDuaYSXa6AevHutqXBA

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Workshop / Seminar Thu, 20 May 2021 06:44:41 -0400 2021-06-09T12:00:00-04:00 2021-06-09T13:00:00-04:00 Off Campus Location RISE (Research. Innovation. Scholarship. Education.) Workshop / Seminar RISE Virtual Talking Circle
No Food for Thought: Food Insecurity and Health Outcomes Across the Life Course (June 10, 2021 10:00am) https://events.umich.edu/event/84138 84138-21620430@events.umich.edu Event Begins: Thursday, June 10, 2021 10:00am
Location: Off Campus Location
Organized By: Osher Lifelong Learning Institute (50+)

Food insecurity has been a persistent social and health concern in the U.S. for the past several decades. This presentation will discuss the negative health outcomes associated with food insecurity for various populations across the life course, how national food insecurity has changed as a result of the COVID pandemic, and how our food assistance programs have responded to alleviating food insecurity at the national level.

Our speaker Dr. Cindy Leung, Assistant Professor of Nutritional Sciences, is a nutrition epidemiologist at U of M School of Public Health. Her research focuses on the experience of food insecurity and its negative influence on health. She is especially interested in using this research to inform the development of federal programs and policies to help alleviate food insecurity and promote good health for vulnerable populations. Dr. Leung earned her M.P.H. from UC Berkeley and her Sc.D. in Nutrition and Epidemiology from Harvard University.

Preregistration is required via the OLLI website or phone (734-998-9351). A link to access the lecture will be e-mailed to you a few days prior to the lecture.

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Class / Instruction Thu, 27 May 2021 09:45:01 -0400 2021-06-10T10:00:00-04:00 2021-06-10T11:30:00-04:00 Off Campus Location Osher Lifelong Learning Institute (50+) Class / Instruction Thursday Lectures
RNA Innovation Seminar featuring Rising Scholars: Khan & McMillan (June 14, 2021 4:00pm) https://events.umich.edu/event/83934 83934-21619166@events.umich.edu Event Begins: Monday, June 14, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

Registration Required: https://umich.zoom.us/webinar/register/WN_uLz-ONHVQPuRINMYUNvBJQ

“CCR5 as a model to examine reporter assays in evaluating translational phenomena”
Yousuf Khan
Knight-Hennessy Scholar
Stanford University

KEYWORDS: dual luciferase, frameshifting, recoding, CCR5
ABSTRACT: During the decoding of a subset of mRNAs, a proportion of ribosomes productively shift to the −1 reading frame at specific slippage-prone sites in a phenomenon known as programmed −1 ribosomal frameshifting (−1 PRF) to generate a frameshifted, C-terminally unique protein. The first experimentally verified occurrence of functionally utilized non-retroelement derived −1 PRF in humans has been reported in the mRNA encoding the immune-functioning C-C chemokine receptor 5 (CCR5). Here, we show that frameshifting does not occur during CCR5 decoding. Apart from its importance in understanding expression of a gene relevant to cancer, an HIV-1 receptor (and the associated claimed rationale for generating the first humans derived from genetically modified embryos), the findings imply that caution is appropriate in assessing results from translational reporter assays.

~and~

“Intersection between RNA methylation and TDP43-mediated toxicity in ALS”
Michael McMillan
Ph.D. candidate
Cellular and Molecular Biology
University of Michigan

KEYWORDS: TDP43, m6A, ALS, RNA stability
ABSTRACT: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease resulting in the death of upper and lower motor neurons. ALS has no known cure and limited therapeutic options, and the underlying pathological mechanisms remain unclear. Despite considerable variability in clinical presentation, over 95% of ALS cases exhibit cytoplasmic inclusions of the RNA binding protein TDP43. Emerging evidence suggests that TDP43 is crucial for RNA stability, and that dysregulation of RNA homeostasis may contribute to ALS pathogenesis.
Methylation of RNA at the 6th position nitrogen (N6-methyladenosine methylation, or m6A) by methyltransferases (writers) or removal of methyl groups by demethylases (erasers) has dramatic effects on RNA stability and translation mediated by a family of RNA biding proteins that recognize methylated RNA (readers). m6A writers and erasers specifically localize to nuclear speckles, membraneless nuclear organelles rich in RNA binding proteins and splicing factors, including TDP43. Together with our data showing that TDP43 regulates RNA stability, these observations suggest that TDP43 may destabilize m6A modified RNA. Here, we show that methylated RNA co-purified with TDP43 from cultured cells via RNA immunoprecipitation, and abrogation of methylation sites disrupted TDP43 binding, suggesting that TDP43 recognizes m6A modified RNA in cellulo. We also noted profound and widespread hypermethylation of coding and non-coding transcripts in ALS spinal cord, many overlapping with confirmed TDP43 target transcripts. Consistent with a central role for m6A modification in TDP43-mediated toxicity, we identified several factors operating within the m6A pathway that enhance or suppress the toxicity of TDP43 in rodent primary cortical neurons via a single-cell CRISPR/Cas9 candidate-based screen. Genetic knockout of the established m6A reader YTHDF2 rescued TDP43 toxicity in primary neurons, and YTHDF2 was also upregulated in ALS postmortem sections. Together, these data imply a fundamental link between m6A RNA modifications and ALS pathogenesis, potentially mediated by TDP43-dependent RNA destabilization.

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Lecture / Discussion Tue, 18 May 2021 14:31:45 -0400 2021-06-14T16:00:00-04:00 2021-06-14T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Yousuf Khan (Stanford) & Mike McMillan (U-M)
Genetic variation, ER stress, Disease modifiers (June 17, 2021 12:00pm) https://events.umich.edu/event/84244 84244-21620803@events.umich.edu Event Begins: Thursday, June 17, 2021 12:00pm
Location: Off Campus Location
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Baharr Chawla

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Workshop / Seminar Tue, 08 Jun 2021 16:49:56 -0400 2021-06-17T12:00:00-04:00 2021-06-17T13:30:00-04:00 Off Campus Location Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow-MCDB-initials-Microscope-on-blue
UM Single Cell Spatial Analysis Program (SCSAP) Kickoff Symposium (June 22, 2021 1:00pm) https://events.umich.edu/event/84222 84222-21620781@events.umich.edu Event Begins: Tuesday, June 22, 2021 1:00pm
Location: Off Campus Location
Organized By: Single Cell Spatial Analysis Program (SCSAP)

The UM BSI SINGLE CELL SPATIAL ANALYSIS PROGRAM KICK OFF SYMPOSIUM

Featuring Keynote Speaker Tzumin Lee, M.D. PhD.
Presenting: Linking single-cell genomics with single-cell genetics.

Date: June 22nd
Time: 1:00 pm -4:30 PM EST
Location: Zoom Webinar
Register at: https://umich.zoom.us/webinar/register/WN_Zax2iT5TReGILR_sQmIZ3w

Additional Mini-talks on: Spatial Transcriptomics, Single Cell RNA-Seq, CyTOF, Multispectral Imaging, Seq-SCOPE, Rare Cell Isolation.

Speakers:
Roger Cone, Ph.D. Evan Keller, Ph.D.
Thomas Wilson, M.D., Ph.D. Jun Li, Ph.D.
Tim Frankel, M.D. Sue Hammoud, Ph.D.
Jun Hee Lee, Ph.D. Olivia Koues, Ph.D.
Sunitha Nagrath, Ph.D. Justin Colacino, Ph.D.
Arvind Rao, Ph.D. Max S. Wicha, M.D.
Patricia Schnepp, Ph.D.

Find us at https://singlecellspatialanalysis.umich.edu
Questions/Comments please contact us at singlecellspatialanalysis@umich.edu

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Workshop / Seminar Fri, 04 Jun 2021 13:26:44 -0400 2021-06-22T13:00:00-04:00 2021-06-22T16:30:00-04:00 Off Campus Location Single Cell Spatial Analysis Program (SCSAP) Workshop / Seminar Dr. Tzumin Lee
PhD Defense: Jiayue Cao (June 23, 2021 3:00pm) https://events.umich.edu/event/84287 84287-21621035@events.umich.edu Event Begins: Wednesday, June 23, 2021 3:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

The stomach and brain interact closely with each other. Their interactions are central to digestive functions and the “gut feeling”. The neural pathways that mediate the stomach-brain interactions include the vagus nerve and the thoracic nerve. Through these nerves, the stomach can relay neural signals to a number of brain regions that span a central gastric network. This gastric network allows the brain to monitor and regulate gastric physiology and allows the stomach to influence emotion and cognition. Impairment of this gastric network may lead to both gastric and neurological disorders, e.g., anxiety, gastroparesis, functional dyspepsia, and obesity. However, the structural constituents and functional roles of the central gastric network remain unclear. In my dissertation research, I leveraged complementary techniques to characterize the central gastric network in rats across a wide range of scales and different gastric states. In animal experiments, I used functional magnetic resonance imaging (fMRI) to map brain activity synchronized with gastric electrical activity and to map brain activations induced by electrical stimulation applied to the cervical vagus or its afferent terminals on the stomach. I also used neurophysiology to characterize gastric neurons in brainstem in response to gastric electrical stimulation. Results from my studies suggest that 1) gastric neurons in the brainstem are selective to the orientation of muscle activity relayed through intramuscular arrays, 2) the central gastric network is intrinsically coupled to gastric slow waves and their amplitude fluctuations primarily via vagal signaling, 3) selective stimulation of the vagus can evoke widespread and fast brain responses and alter functional connectivity within and beyond the central gastric network. My dissertation research contributes to the foundation of mapping and characterizing the central and peripheral mechanisms of gastric interoception and sheds new light on where and how to stimulate the peripheral nerves to modulate stomach-brain interactions.



Date: Wednesday, June 23, 2021

Time: 3:00 PM

Zoom: https://umich.zoom.us/j/2757414653

Chair: Dr. Zhongming Liu

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Lecture / Discussion Tue, 15 Jun 2021 23:04:33 -0400 2021-06-23T15:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
PhD Defense: Eric Charles Hobson (June 24, 2021 10:30am) https://events.umich.edu/event/84237 84237-21620794@events.umich.edu Event Begins: Thursday, June 24, 2021 10:30am
Location: Off Campus Location
Organized By: Biomedical Engineering

Mechanical testing of viscoelastic biomaterials is of critical importance in biomedical engineering, enabling basic research into the role of the extracellular matrix, investigatory and diagnostic testing of tissues and biofluids, and the development and characterization of tissue engineered therapeutics. Conventional material testing approaches used for soft biomaterials generally require force application through direct contact with a sample, leading to potential contamination and damage, and thereby limiting these approaches to end-point measurements. To overcome these limitations, we have developed a new measurement technique, Resonant Acoustic Rheometry (RAR), which enables high-throughput, quantitative, and non-contact viscoelastic characterization of biomaterials, soft tissues, and biological fluids.



RAR uses ultrasonic pulses to both generate microscale perturbations and measure the resulting resonant oscillations at the surface of soft materials using standard labware. Resonant oscillatory properties obtained from the frequency spectra of the surface oscillations, including the resonant frequency and the damping coefficient, are used to quantify material properties such as shear modulus, shear viscosity, and surface tension in both viscoelastic solids and liquids.



We developed a prototype RAR system and tested it on a range of soft biomaterials, with shear moduli ranging from under 100 Pa to over 50 kPa, including fibrin, gelatin, and polyethylene glycol (PEG). Shear moduli measured using RAR were validated both computationally using finite element analysis and experimentally using conventional shear rheometry, with excellent linear correlation in measured elasticity between techniques (R2 > 0.95). By performing parallel RAR experiments using microwells of different sizes, we verified that resonant oscillatory behaviors could be used to quantify the intrinsic viscoelastic properties of a material. We also demonstrated the rapid, non-contact monitoring of changes in material properties over a variety of temporal scales, ranging from processes occurring on the order of milliseconds to those occurring over hours and days. High temporal resolution RAR measurements, with sampling intervals as low as 0.2 seconds, were used to characterize the gelation process. Characteristic features of the resonant surface waves during phase transition were applied to identify the gel point for various hydrogels. High sample throughput was demonstrated by performing longitudinal RAR testing to explore the impact of hydrogel polymer and crosslinker concentration on both reaction kinetics and final mechanical properties in full factorial experiments consisting of over 15,000 unique measurements. We were able to identify individual effects of design parameters as well as interactions that led to unexpected mechanical properties, demonstrating the importance of combinatorial methods and high-throughput mechanical characterization in material design.



These studies demonstrate that RAR can rapidly and accurately assess the mechanical properties of soft viscoelastic biomaterials. The measurements generated are analogous to those produced using conventional mechanical testing, and RAR is further capable of longitudinal viscoelastic studies over time. RAR applies automation in both data collection and analysis, allowing high throughput measurement of an array of samples without contact or the need for manual intervention. Furthermore, RAR uses standard microwell plates, which simplifies sample preparation and handling. The viscoelastic properties of soft biomaterials are relevant in a wide range of applications, including for clinical diagnostic assays and the development of hydrogel materials for regenerative medicine. RAR represents a fast, accurate, and cost-effective method for materials characterization in these applications.



June 24 - 10:30 AM

Zoom: https://umich.zoom.us/meeting/register/tJcsd-iurTosGdNn_gR-FbOCe5TUR09Y58WV

Co-Chairs: Dr. Cheri Deng and Dr. Jan Stegmann

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Lecture / Discussion Tue, 22 Jun 2021 16:37:33 -0400 2021-06-24T10:30:00-04:00 2021-06-24T11:30:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
RNA Collaborative Seminar (June 30, 2021 4:00pm) https://events.umich.edu/event/84166 84166-21620522@events.umich.edu Event Begins: Wednesday, June 30, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_6OEQ6sDAQ0-21GHm6d7VEQ

“Dynamic multivalent interactions drive mammalian RNA regulation”
Sethu Pitchiaya, Ph.D.
Dept of Urology

and

"Characterizing cellular RNA-protein interaction networks with chemical probes"
Chase Weidmann, Ph.D.
Dept of Biological Chemistry

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Lecture / Discussion Wed, 09 Jun 2021 15:28:29 -0400 2021-06-30T16:00:00-04:00 2021-06-30T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Sethu Pitchiaya & Chase Weidmann
PhD Defense: Hans Zander (July 9, 2021 9:00am) https://events.umich.edu/event/84346 84346-21623406@events.umich.edu Event Begins: Friday, July 9, 2021 9:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

Spinal cord stimulation (SCS) is a neuromodulation technique that applies electrical stimulation to the spinal cord to alter neural activity or processing. While SCS has historically been used as a last resort therapy for chronic pain management, novel applications and technologies have recently been developed that either increase the efficacy of treatment for chronic pain or drive neural activity to produce muscular activity/movement following a paralyzing spinal cord injury (SCI). Despite these recent innovations, there remain fundamental questions concerning the neural recruitment underlying these efficacious results. This work evaluated the neural activity and mechanisms for two novel SCS applications: closed-loop spinal cord stimulation for pain management, and ventral, high frequency spinal cord stimulation (HF-SCS) for inspiratory muscle activation following a SCI.

To evaluate neural activity, I developed computational models of SCS. Models consisted of 3 components: a finite element model (FEM) of the spinal cord to predict voltages during stimulation, biophysical neuron models, and algorithms to apply time-dependent extracellular voltages to the neuron models and simulate their response. While this cutting-edge modeling methodology could be used to predict neural activity following stimulation, it was unclear how common anatomical or technical model simplifications affected neural predictions. Therefore, the initial goal of this work was to evaluate how modeling assumptions influence neural behavior.

My initial work identified how several relevant anatomical and technical factors influence model predictions of neural activity. To evaluate these factors, I designed an FEM of a T9 thoracic spine with an implanted electrode. Then, I sequentially removed details from the model and quantified the changes in neural predictions. I identified several factors with profound (>30%) impacts on neural thresholds, including overall model impedance (for voltage-controlled stimulation), the presence of a detailed vertebral column, and dura mater conductivity. I also identified several factors that could safely be ignored in future models. This work will be invaluable as a guide for future model development.

Next, I developed a canine model to evaluate T2 ventral HF-SCS for inspiratory muscle activation. I designed and positioned two neuron models hypothesized to lead to inspiratory behavior: ventrolateral funiculus fibers (VLF) leading to diaphragm activation and inspiratory intercostal motoneurons. With this model, I predicted robust VLF and T2-T5 motoneuron recruitment within the physiologic range of stimulation. Additionally, I designed two stimulation leads that maximize inspiratory neuron recruitment. The finalized leads were evaluated via in vivo experiments, which found excellent agreement with the model. This work builds our mechanistic understanding of this novel therapy, improves its implementation, and aids in future translational efforts towards human subjects.

Finally, I developed a computational model to evaluate closed-loop stimulation for chronic pain. This work characterized the neural origins of the evoked compound action potential (ECAP), the controlling biomarker of closed-loop stimulation. I modified my modeling methodology to predict ECAPs generated during low thoracic dorsal stimulation in humans, which matched with experimental measurements. This modeling work showed that ECAP properties depend on activation of a narrow range of neuron diameters and quantified how anatomical and stimulation factors (CSF thickness, stimulation configuration, lead position, pulse width) influence ECAP morphology, timing, and neural recruitment. These results improve our mechanistic understanding of closed-loop stimulation and may lead to expanded clinical utility as well as better validation of future SCS computational models.

Date: Friday, July 9, 2021

Time: 9:00 AM EDT

Zoom: https://umich.zoom.us/j/96847307388

Chair: Dr. Scott Lempka

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Lecture / Discussion Tue, 22 Jun 2021 16:45:26 -0400 2021-07-09T09:00:00-04:00 2021-07-09T10:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Department of Computational Medicine & Bioinformatics || Weekly Seminar Series (September 8, 2021 4:00pm) https://events.umich.edu/event/86237 86237-21632210@events.umich.edu Event Begins: Wednesday, September 8, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

Structural variants (SVs) are a source of pathogenic variants in a clinical referral population, however, they are often under-reported due to technical limitations of detection and difficulty with clinical interpretation. For example, mobile element insertions (MEIs) are estimated to lead to a positive finding in 1 out of 1000 rare genetic disease cases, yet the numbers are far lower in clinical diagnostic laboratories. Targeted NGS with short insert size libraries, unlike genome sequencing, will have very few discordant read pairs to indicate the presence of an SV. We, therefore, developed an SV detection tool called SCRAMble (Soft Clipped Read Alignment Mapper) to identify SV breakpoints in targeted NGS.

We applied SCRAMble to a prospective clinical referral cohort for exome sequencing to identify deletions and MEIs. We also applied SCRAMble to a hereditary cancer panel assay for the identification of a large inversion involving the MSH2 gene that causes Lynch syndrome. Adding breakpoint detection to clinical targeted sequencing identifies positive findings which were missed by prior testing and by other variant callers. Detecting breakpoints allows for more precise interpretation and for more targeted confirmation assays. By applying SV breakpoint detection, we are able to diagnose ~0.3% more cases. While this is a modest gain in diagnostic yield, for the patients and families involved, a positive diagnosis, even after prior testing, can have a meaningful impact on their lives.

Zoom link: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Thu, 02 Sep 2021 14:28:18 -0400 2021-09-08T16:00:00-04:00 2021-09-08T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual Rebecca Torene, Associate Director of Genomics Research | Data Science at GeneDx
Human Genetics Annual Retreat - Keynote Seminar (September 10, 2021 2:00pm) https://events.umich.edu/event/86250 86250-21632243@events.umich.edu Event Begins: Friday, September 10, 2021 2:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Department of Human Genetics

FRIDAY, SEPTEMBER 10
2:00 PM – 3:00 PM EST
BSRB KAHN AUDITORIUM
109 ZINA PITCHER PL, ANN ARBOR

HOSTED BY:
Jacob Mueller, Ph.D.
Associate Professor of Human Genetics
Associate Professor of Obstetrics and Gynecology
Associate Professor of Urology
University of Michigan

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Lecture / Discussion Thu, 02 Sep 2021 16:36:15 -0400 2021-09-10T14:00:00-04:00 2021-09-10T15:00:00-04:00 Taubman Biomedical Science Research Building Department of Human Genetics Lecture / Discussion DHG RETREAT 2021_Keynote Speaker Flyer
RNA Innovation Seminar (September 13, 2021 4:00pm) https://events.umich.edu/event/86155 86155-21631746@events.umich.edu Event Begins: Monday, September 13, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

"Recent improvements in modeling and design of RNA-only structures"

ABSTRACT: The discovery and design of biologically important RNA molecules is outpacing three-structural characterization. I'll describe results from my and Wah Chiu's groups that demonstrate that cryo-electron microscopy can resolve maps of several kinds of RNA-only systems. These maps enable subnanometer-resolution 3D coordinate estimation when complemented with multidimensional chemical mapping and Rosetta DRRAFTER computational modeling. If time allows, I'll describe work from the Eterna project to stabilize mRNA molecules to help accelerate worldwide COVID immunization.

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Lecture / Discussion Thu, 02 Sep 2021 12:54:16 -0400 2021-09-13T16:00:00-04:00 2021-09-13T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Rhiju Das, Stanford University
Science Success Series | The Gifts of Imperfection: Guideposts for Wholehearted Living (September 14, 2021 3:30pm) https://events.umich.edu/event/85312 85312-21626215@events.umich.edu Event Begins: Tuesday, September 14, 2021 3:30pm
Location: Off Campus Location
Organized By: Science Learning Center

Has the fear of falling short of perfection prevented you from putting yourself out there, trying something new, or sharing your ideas? Come join this session to learn about how to cultivate wholehearted living practices through the work of Dr. Brene’ Brown’s book “The Gifts of Imperfection: Guideposts for Wholehearted Living”. This workshop will introduce you to daily actions you can take to let go of the things that hold you back and allow you to cultivate behaviors that support living wholeheartedly.

Register on Sessions: https://myumi.ch/wlBNv

Email ScienceSuccessSeries@umich.edu with any questions.

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Workshop / Seminar Tue, 17 Aug 2021 10:25:25 -0400 2021-09-14T15:30:00-04:00 2021-09-14T17:00:00-04:00 Off Campus Location Science Learning Center Workshop / Seminar The Gifts of Imperfection Book Cover
Microbiome Seminar: Mechanisms of colonization resistance to Salmonella Typhimurium in the mouse (September 15, 2021 9:00am) https://events.umich.edu/event/86701 86701-21635601@events.umich.edu Event Begins: Wednesday, September 15, 2021 9:00am
Location: Off Campus Location
Organized By: Michigan Microbiome Project

Abstract: Colonization resistance is one of the primary benefits the gut microbiota provides for the host animal. How the gut bacterial community remains stable and resists invasion has been a subject of much research over many decades. We are using Salmonella Typhimurium as a model pathogen in mice, in hopes of discovering new facets to this well-studied interaction. In vitro and in vivo results point to amino acids as a potentially important nutrient for Salmonella. Key protective anaerobic bacteria also ferment amino acids, thus giving support for a nutrient competition basis for colonization resistance.

Hosts: Matt Ostrowski & Celeste Alexander
Michigan Microbiome Project
Zoom Meeting: https://umich.zoom.us/j/98500663735

https://microbe.med.umich.edu/about/seminars/mechanisms-colonization-resistance-salmonella-typhimurium-mouse

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Livestream / Virtual Fri, 10 Sep 2021 11:15:26 -0400 2021-09-15T09:00:00-04:00 2021-09-15T10:00:00-04:00 Off Campus Location Michigan Microbiome Project Livestream / Virtual Michigan Microbiome Project
Department of Computational Medicine & Bioinformatics Weekly Seminar Series (September 15, 2021 4:00pm) https://events.umich.edu/event/86598 86598-21635116@events.umich.edu Event Begins: Wednesday, September 15, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

Chromosomal instability (CIN) results in the accumulation of large-scale losses, gains, and rearrangements of DNA. The broad genomic complexity caused by CIN is a hallmark of cancer, however, there is no systematic framework to measure different types of CIN and their impact on clinical phenotypes. Here, we evaluate the extent, diversity and origin of chromosomal instability across 7,880 tumors representing 33 cancer types from the TCGA collection. We present a compendium of 17 copy number signatures characterizing specific types of CIN, with putative aetiologies supported by multiple independent data sources. The signatures predict drug response and identify new drug targets. Our framework refines the understanding of impaired homologous recombination, one of the most therapeutically targetable types of CIN. Our results illuminate a fundamental structure underlying genomic complexity and provide a resource to guide future CIN
research in human cancers.

Bio:

Florian Markowetz is a Senior Group Leader at the Cancer Research UK Cambridge Institute. He is a Royal Society Wolfson Research Merit Award holder and received a CRUK Future Leader in Cancer Research prize. He holds degrees in Mathematics (Dipl. math.) and Philosophy (M.A.) from the University of Heidelberg and a Dr. rer. nat. (PhD equivalent) in Computational Biology from Free University Berlin, for which he was awarded an Otto-Hahn Medal by the Max Planck Society. His group at the CRUK Cambridge Institute combines computational work on cancer evolution and image analysis of the tumor tissue with experimental work on understanding key cancer mechanisms like the estrogen receptor.

Zoom link: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Thu, 09 Sep 2021 11:24:05 -0400 2021-09-15T16:00:00-04:00 2021-09-15T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual Florian Markowetz (Senior Group Leader at the Cancer Research UK Cambridge Institute)
U-M Structure Seminar: "Structural basis for redox sensing by the cyanobacterial transcription regulator RexT" (September 17, 2021 10:00am) https://events.umich.edu/event/85431 85431-21626418@events.umich.edu Event Begins: Friday, September 17, 2021 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

Bin Li, Ph.D.
Postdoctoral Research Fellow
University of Michigan, Bridwell-Rabb Lab

Hybrid: LSI Library and Zoom - https://umich.zoom.us/j/97763780708 (Password: structure)

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Workshop / Seminar Tue, 07 Sep 2021 14:09:31 -0400 2021-09-17T10:00:00-04:00 2021-09-17T11:00:00-04:00 Life Sciences Institute U-M Structural Biology Workshop / Seminar U-M Structure
Building Toward Flooding Resilience: Perspectives from the Field (September 21, 2021 12:00pm) https://events.umich.edu/event/86206 86206-21632182@events.umich.edu Event Begins: Tuesday, September 21, 2021 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Panelists include: Ricky Ackerman (Eastside Community Network), Erma Leaphart (Sierra Club), and Peter Larson (Lecturer, Epidemiology & Researcher, Institute for Social Research; Univ of MI), Moderator: Angie Reyes (Detroit Hispanic Development Corporation). ZOOM https://umich.zoom.us/j/94323672749

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Lecture / Discussion Thu, 02 Sep 2021 12:25:11 -0400 2021-09-21T12:00:00-04:00 2021-09-21T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion R&R: Residents and Researchers Tuesday Talks at 12 on environment, health, and community
The Origin and Evolution of Earth I (September 22, 2021 1:00pm) https://events.umich.edu/event/85553 85553-21626843@events.umich.edu Event Begins: Wednesday, September 22, 2021 1:00pm
Location: Off Campus Location
Organized By: Osher Lifelong Learning Institute (50+)

The class will follow Earth from the Big Bang to the formation of continents using Robert Hazen’s excellent DVD lectures from the Teaching Company supplemented with the latest findings. We’ll view two 30 minute lectures per class, each followed by 20 minutes for questions and discussion. (The full course has 48 lectures; we’ll cover the first 24 in the fall with the final 24 in the spring.)

Study group leader Dick Chase has worked 27 years as a research physicist for Ford and taught physics at several levels. At OLLI, he has taught 20 science courses and led 5 book discussion groups.

This study group will meet on Wednesdays for twelve weeks beginning on September 22 (no class on November 24). Preregistration is required via the OLLI website or phone. A link to access the study group will be e-mailed prior to the first session.

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Class / Instruction Sat, 28 Aug 2021 19:08:11 -0400 2021-09-22T13:00:00-04:00 2021-09-22T15:00:00-04:00 Off Campus Location Osher Lifelong Learning Institute (50+) Class / Instruction OLLI Study Groups
Department of Computational Medicine & Bioinformatics Weekly Seminar (September 22, 2021 4:00pm) https://events.umich.edu/event/87282 87282-21640718@events.umich.edu Event Begins: Wednesday, September 22, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

Histones are small proteins that package DNA into chromosomes, and a large number of studies have showed that several post-translational modification (PTM) sites on the histones are associated with both gene activation and silencing. Along with DNA and small non-coding RNA, histone PTMs make up epigenetic mechanisms that control gene expression patterns outside of DNA sequence mutations. Dysregulation of these chromatin networks underlie several human diseases such as cancer. Here I will give an update on technology advancements that have allowed for high-throughput quantitative analyses of histone PTMs and chromatin structure, and how we are applying these methods to understand epigenetic reprogramming found in malignant peripheral nerve sheath tumors (MPNSTs). MPNST is an aggressive sarcoma with recurrent loss of function alterations in polycomb-repressive complex 2 (PRC2), a histone-modifying complex involved in transcriptional silencing.

Zoom Link: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Mon, 20 Sep 2021 15:27:41 -0400 2021-09-22T16:00:00-04:00 2021-09-22T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual
U-M Structure Seminar: "Structure of a meiosis-specific complex central to BRCA2 localization at recombination sites (September 24, 2021 10:00am) https://events.umich.edu/event/85432 85432-21626419@events.umich.edu Event Begins: Friday, September 24, 2021 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

Jayakrishnan Nandakumar, Ph.D.
University of Michigan
Associate Professor of Molecular, Cellular and Developmental Biology, College of Literature, Science, and the Arts

Hybrid: LSI Library and Zoom - https://umich.zoom.us/j/97763780708 (Password: structure)

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Workshop / Seminar Tue, 07 Sep 2021 14:09:51 -0400 2021-09-24T10:00:00-04:00 2021-09-24T11:00:00-04:00 Life Sciences Institute U-M Structural Biology Workshop / Seminar U-M Structure
Neighborhood Greening for Stormwater Management: What Matters for Residents (September 28, 2021 12:00pm) https://events.umich.edu/event/86956 86956-21637625@events.umich.edu Event Begins: Tuesday, September 28, 2021 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Panelists: Kenyetta Campbell (Cody Rouge Community Action Alliance), Barb Matney (Warrendale Community Organization), Joan Nassauer (Univ of MI), and Natalie Sampson (Univ of MI Dearborn). Moderated by Amy Schulz (Univ of MI).

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Workshop / Seminar Tue, 14 Sep 2021 16:47:14 -0400 2021-09-28T12:00:00-04:00 2021-09-28T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Workshop / Seminar R&R: Residents and Researchers Tuesday Talks at 12 on environment, health, and community
Department of Computational Medicine & Bioinformatics Weekly Seminar (September 29, 2021 4:00pm) https://events.umich.edu/event/87515 87515-21642906@events.umich.edu Event Begins: Wednesday, September 29, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

Human complex traits result from genetic and environmental factors, and from their interactions. Many of these effects are mediated by changes in gene regulation. Indeed, most genetic variants associated with complex trait variation in humans are in regulatory regions. I will present some of our recent studies on gene-environment interactions in gene regulation, with a specific focus on cardiovascular health. I will present evidence that gene-environment interactions in molecular phenotypes are frequent, account for a substantial portion of complex trait variation and modify genetic risk for disease.

Research Focus:

My lab is interested in understanding the genetic and molecular basis of inter-individual and inter-population differences in complex phenotypes. We combine evolutionary and functional genomics approaches to study intermediate phenotypes (e.g.: transcription factor binding, gene expression, protein secretion, etc.) and how they are affected by gene-environment interactions. Our research is funded by the NIH.

Zoom link: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Fri, 24 Sep 2021 14:01:53 -0400 2021-09-29T16:00:00-04:00 2021-09-29T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual Francesca Luca, PhD (Wayne State University)
LHS Collaboratory 2021-2022 Kick-off Session (September 30, 2021 12:00pm) https://events.umich.edu/event/84725 84725-21624492@events.umich.edu Event Begins: Thursday, September 30, 2021 12:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Presentation 1
The Learning Health (Record) System

Speaker:
Philip R.O. Payne, PhD, FACMI, FAMIA, FAIMBE, FIAHSI
Janet and Bernard Becker Professor and Director, Institute for Informatics (I2), Associate Dean for Health information and Data Science, Chief Data Scientist, at Washington University in St. Louis

This presentation will explore the ways in Biomedical Data Science and Informatics research are helping to realize the potential of EHR technologies in the context of creating an LHS, from the optimization of workflow and human factors, to the generation of reproducible and systematic clinical phenotypes, to the delivery of emergent knowledge to both providers and patients via advance clinical decision support systems.

Presentation 2
Techniques and Challenges for EHR Phenotyping

Speaker:
Lisa Bastarache, MS
Research Associate Professor Department of Biomedical Informatics,
Vanderbilt University

Electronic health records (EHR) contain a wealth of real world data that can be used for research purposes. However, extracting phenotype information from EHRs can be challenging. EHR phenotyping can be divided into two types: (1) Fast phenotyping which seeks to capture a broad swath of the medical phenome, and is often accomplished using coded EHR data (e.g. billing codes) and (2) slow phenotyping that seeks to achieve high precision and recall for a single phenotype, and often uses multiple EHR data types (e.g. medications, text, lab results). This talk will describe specific use-cases for both fast and slow phenotyping, and review challenges that are commonly encountered in creating research-grade EHR phenotypes.

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Lecture / Discussion Mon, 27 Sep 2021 11:13:17 -0400 2021-09-30T12:00:00-04:00 2021-09-30T13:30:00-04:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion LHS Collaboratory Logo
U-M Structure Seminar: "Discovery and structural characterization of a diastereoselective intramolecular Diels-Alderase." (October 1, 2021 10:00am) https://events.umich.edu/event/86435 86435-21634312@events.umich.edu Event Begins: Friday, October 1, 2021 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

Sebastian Rivera
Graduate Student
University of Michigan, Sherman Lab

Hybrid: LSI Library and Zoom - https://umich.zoom.us/j/97763780708 (Password: structure)

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Workshop / Seminar Tue, 07 Sep 2021 14:16:37 -0400 2021-10-01T10:00:00-04:00 2021-10-01T11:00:00-04:00 Life Sciences Institute U-M Structural Biology Workshop / Seminar U-M Structure
RNA Innovation Seminar (October 4, 2021 4:00pm) https://events.umich.edu/event/86162 86162-21631753@events.umich.edu Event Begins: Monday, October 4, 2021 4:00pm
Location: 1027 E. Huron Building
Organized By: Center for RNA Biomedicine

"Fluorescent nucleoside analogues with new properties"

HYBRID EVENT
in-person: Forum Hall, Palmer Commons
Zoom: https://umich.zoom.us/webinar/register/WN__vvE2dtHQi-R3h05JUHBzQ

ABSTRACT
Fluorescent nucleoside analogues (FNAs) are powerful probes for studying the structure and dynamics of nucleic acids, which are vital to understanding RNA function, DNA damage repair, nucleic acid–protein interactions, regulatory mechanisms for gene expression, and other aspects of nucleic acid function. Existing FNAs are prone to quenching by base pairing and stacking, are clustered at the blue–green end of the visible spectrum, and have limited brightness as compared with conventional fluorophores. Studies of nucleic acid function would benefit greatly from overcoming these limitations. We have designed, synthesized, and studied a series of fluorescent pyrimidine analogues, aiming to address these limitations and develop a detailed understanding of the relationships between chemical structure and fluorescent responses to local environment in nucleic acids. Included in this series is a tricyclic cytidine analogue DEAtC that is nearly non-fluorescent as a nucleoside, but responds to matched base pairing and stacking with a fluorescence turn-on. A chlorinated tricyclic cytidine 8-Cl-tCO reports on local environment by changes in the vibrational fine structure of its emission spectra. To address the problem of limited brightness, we have design and synthesized a new NFA that we call ABN, which has a conjugated push–pull system similar to those found in bright fluorophores such as rhodamines. ABN is the brightest known FNA when present in duplex nucleic acids, and it is readily detected in single-molecule fluorescence measurements using both 1-photon and 2-photon excitation. Collectively, these FNAs offer new capabilities for biophysical studies on nucleic acids. Comparisons of their structure and properties help to reveal mechanisms for fluorescence changes in response to local environment in nucleic acids.

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Lecture / Discussion Fri, 10 Sep 2021 11:29:04 -0400 2021-10-04T16:00:00-04:00 2021-10-04T17:00:00-04:00 1027 E. Huron Building Center for RNA Biomedicine Lecture / Discussion Byron Purse, San Diego State University
Science Success Series | Wealth Beyond Health (October 5, 2021 3:30pm) https://events.umich.edu/event/85496 85496-21626704@events.umich.edu Event Begins: Tuesday, October 5, 2021 3:30pm
Location: Off Campus Location
Organized By: Science Learning Center

There are limitless options for a pre-med student beyond medical school and a traditional career as a doctor. Join us in exploration of other career tracks with alumni and experts. There is a world of options to apply skills in science, critical problem solving, and a desire to help people. Find your option for wealth beyond health.

Register on Sessions: https://myumi.ch/mne5z

Email ScienceSuccessSeries@umich.edu with any questions.

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Workshop / Seminar Fri, 20 Aug 2021 11:44:31 -0400 2021-10-05T15:30:00-04:00 2021-10-05T17:00:00-04:00 Off Campus Location Science Learning Center Workshop / Seminar
Characterizing the Global Drinking Water Virome (October 6, 2021 9:00am) https://events.umich.edu/event/87582 87582-21644197@events.umich.edu Event Begins: Wednesday, October 6, 2021 9:00am
Location: Off Campus Location
Organized By: Michigan Microbiome Project

Bridget Hegarty, Ph.D.
Postdoctoral Scholar, Civil and Environmental Engineering

Hosts: Celeste Alexander
Matt Ostrowski
Thomas Schmidt
Michigan Microbiome Project

Abstract: In drinking water distribution systems, previous research on viruses has focused on tracking and eliminating viral pathogens to limit the spread of waterborne diseases. However, viruses may impact drinking water quality and human health in other less direct ways by influencing the proliferation of bacteria that can both lead to human disease, as well as exacerbate water quality issues from nitrification and corrosion. Previous metagenomics studies have focused on how bacteria influence water quality, at most identifying the presence of viral proteins or estimating the viral fraction. For this reason, fundamental information about how viruses influence microbial populations in drinking water remains unknown. In this presentation, I will address this gap by providing an overview of global drinking water viral assemblages using sequences mined from publicly available drinking water metagenomes. These sequences provide a first glimpse of the taxonomic and metabolic diversity of the drinking water virome, as well as indicate the parameters shaping viral diversity. Environmental conditions, as well as differences in sample collection and processing were found to influence the viral assemblages. Differences in water quality between distribution systems that used residual disinfectants and those that did not led to clear differences in the viral taxonomic diversity and metabolic potential of these samples. For instance, drinking water distribution systems that used a residual disinfectant had fewer distinct viral populations (observed taxa; Wilcoxon rank sum test p-value = 0.0003) and less even viral assemblages (Shannon index; Wilcoxon rank sum test p-value = 0.0001). Additionally, genes related to surviving oxidative stress were overabundant in distribution systems that used a residual disinfectant, while genes related to nitrogen metabolism were overabundant in distribution systems without a residual disinfectant. Laying important groundwork for better understanding the impact that viruses have on the bacteria of drinking water distribution systems, this study demonstrates that viral assembleges are diverse across drinking water systems and shaped by treatment choices, including the use of a residual disinfectant.

Zoom Meeting: https://umich.zoom.us/j/92240564900

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Lecture / Discussion Mon, 27 Sep 2021 13:11:32 -0400 2021-10-06T09:00:00-04:00 2021-10-06T10:00:00-04:00 Off Campus Location Michigan Microbiome Project Lecture / Discussion Michigan Microbiome Project
“This is Our Lane: talking with Patients about Racism” and “Structural Racism & the Impact on Incarcerated Midlife Women” (October 6, 2021 3:00pm) https://events.umich.edu/event/87467 87467-21642281@events.umich.edu Event Begins: Wednesday, October 6, 2021 3:00pm
Location: Off Campus Location
Organized By: Center for Midlife Science

Registration required: https://umich.zoom.us/webinar/register/WN_7wXT6ve8S2qqy4dAKi1ckA

Moderators: Sherri-Ann M. Burnett-Bowie, MD, MPH, Department of Medicine, Massachusetts General Hospital & Harvard Medical School; and Gloria Bachmann, MD, Rutgers Robert Wood Johnson Medical School.

Speakers: “This is Our Lane: talking with Patients about Racism” with Michelle S. Diop, MD, ScM, Department of Medicine, Massachusetts General Hospital & Harvard Medical School; and Sascha N. Murillo MD, Department of Medicine, Massachusetts General Hospital & Harvard Medical School; and “Structural Racism and the Impact on Incarcerated Midlife Women” with Juana Hutchinson-Colas, MD, Rutgers Robert Wood Johnson Medical School.

Location: This will be an online event. Please register for more information.

Sponsored by: Women’s Midlife Health (journal), Center for Midlife Science at the University of Michigan, Massachusetts General Hospital Department if Medicine Diversity and Inclusion Board.

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Lecture / Discussion Thu, 23 Sep 2021 17:27:30 -0400 2021-10-06T15:00:00-04:00 2021-10-06T16:00:00-04:00 Off Campus Location Center for Midlife Science Lecture / Discussion Webinar Series on Structural Racism and Midlife Health
Examining the Health Reform Monitoring Survey and the Well-Being and Basic Needs Survey Presented by the Urban Institute (October 12, 2021 2:00pm) https://events.umich.edu/event/87749 87749-21645527@events.umich.edu Event Begins: Tuesday, October 12, 2021 2:00pm
Location: Off Campus Location
Organized By: Inter-university Consortium for Political and Social Research

Join the Health and Medical Care Archive (HMCA) at the Inter-university Consortium for Political and Social Research (ICPSR) on October 12 at 2:00 pm EDT for a free webinar, “Examining the Health Reform Monitoring Survey and the Well-Being and Basic Needs Survey Presented by the Urban Institute” featuring Stephan Zuckerman and Michael Karpman. The webinar is hosted by HMCA, a data repository funded by the Robert Wood Johnson Foundation.

Participants will get an overview of the surveys, learn about key findings from the latest data, and discover ways these studies can be used in health research. Participants will learn about the resources available on the RWJF and HMCA websites and have the opportunity to ask questions.

Register with this link: https://myumi.ch/YyEe2

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Presentation Thu, 30 Sep 2021 16:44:15 -0400 2021-10-12T14:00:00-04:00 2021-10-12T15:00:00-04:00 Off Campus Location Inter-university Consortium for Political and Social Research Presentation Webinar Announcement with the Urban Institute and the Institute for Social Research on the Health Reform Monitoring Survey and the Well-Being and Basic Needs Survey
Prebiotic Modulation of the Gut Microbiota for Health and Wellness (October 13, 2021 9:00am) https://events.umich.edu/event/88066 88066-21650106@events.umich.edu Event Begins: Wednesday, October 13, 2021 9:00am
Location: Off Campus Location
Organized By: Michigan Microbiome Project

Director of the UNC Microbiome Core
Associate Professor of Medicine in the School of Medicine at UNC Chapel Hill

Speaker Profile: M. Andrea Azcarate-Peril, Ph. D. is Associate Professor of Medicine in the School of Medicine at UNC Chapel Hill. Dr. Azcarate-Peril currently conducts research in modulation of the host-associated microbiota by prebiotics and probiotics. She has extensive experience in physiology and functional genomics of probiotic strains. Dr. Azcarate-Peril uses molecular biology, genomics, and next-generation sequencing tools to address questions relevant to the role of the intestinal microbiota in human health and disease.

Zoom Call: https://umich.zoom.us/j/91808794117

Hosts:
Matt Ostrowski, Ph.D.
Celeste Alexander, Ph.D.
Thomas Schmidt, Ph.D.
Alfredo Guerra, Ph.D.

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Meeting Mon, 11 Oct 2021 04:48:39 -0400 2021-10-13T09:00:00-04:00 2021-10-13T10:00:00-04:00 Off Campus Location Michigan Microbiome Project Meeting Michigan Microbiome Project
Department of Computational Medicine & Bioinformatics Weekly Seminar (October 13, 2021 4:00pm) https://events.umich.edu/event/86441 86441-21634316@events.umich.edu Event Begins: Wednesday, October 13, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

Understanding the genetic and molecular architecture of human disease is accelerated by robust model development and large-scale molecular profiling. I will present two studies leveraging big data analytics or automated machine learning to dissect human disease complexities: 1) Molecular and clinical signatures of SARS-CoV-2 infection in the US marines. This analysis revealed strong antiviral innate immunity set point in females contributing to sex differences in both molecular and clinical response to SARS-CoV-2 infection. A set of accurate biomarkers capable of detecting PCR false negative infections was implemented on small footprint devices. 2) Automated machine learning to interpret the effects of genetic variants. An automated framework, AMBER, was developed for efficiently searching neural network architectures to model genomic sequences. AMBER is useful in various biological applications, including fine mapping variants, partitioning genetic heritability, and in personalized medicine enabled by CRISPR/Cas9 genome editing. Together, these efforts demonstrate quantitative methods coupled with large-scale biomedical data as an effective avenue to decode human regulatory and disease biology.

Short Bio:

Frank Zhang is a Flatiron research fellow with Olga Troyanskaya at the Simons Foundation and Princeton University since 2019. Prior to that, he obtained his PhD at UCLA with Yi Xing. His research focuses on machine learning and statistical method developments for the prediction and interpretation of human molecular and genetic variations using biological big data. Recently, he works on adopting and developing cutting-edge neural architecture search methods to automate the design of deep neural networks in genomics. He is also interested in making deep learning in biomedicine more interpretable and equitable.

Zoom link: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Tue, 07 Sep 2021 14:45:38 -0400 2021-10-13T16:00:00-04:00 2021-10-13T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual
U-M Structure Seminar: "Watching enzymes at work: Structure and dynamics of cytochromes P450 using NMR" (October 15, 2021 10:00am) https://events.umich.edu/event/87284 87284-21640722@events.umich.edu Event Begins: Friday, October 15, 2021 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

Thomas Pochapsky, Ph.D.
Professor of Chemistry and Biochemistry
Brandeis University

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Workshop / Seminar Mon, 20 Sep 2021 16:31:08 -0400 2021-10-15T10:00:00-04:00 2021-10-15T11:00:00-04:00 Life Sciences Institute U-M Structural Biology Workshop / Seminar U-M Structure
RNA Innovation Seminar: Tim Stasevich, Ph.D., Colorado State University (October 18, 2021 4:00pm) https://events.umich.edu/event/86166 86166-21631758@events.umich.edu Event Begins: Monday, October 18, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

KEYWORDS: translational regulation, gene expression, fluorescence microscopy, intrabodies, single-molecule imaging

ABSTRACT: My lab is creating technology to image mRNA translation in real time and with single-molecule precision in living cells. In this talk, I will introduce our technology and describe how it can be used to amplify fluorescence from newly synthesized proteins as they are being translated from single mRNAs. I will show how we quantify these signals to determine the size, shape, subcellular localization, and mobilities of mRNA translation sites, as well as their protein synthesis dynamics. I will then highlight a few recent applications of our technology, focusing mainly on a new biosensor we have developed to quantify how individual regulatory factors impact single mRNA translation dynamics. Using this biosensor, we provide evidence that human Argonaute2 (Ago2) shuts down translation by down regulating translation initiation on the minutes timescale and helping usher translationally silent mRNAs into P-bodies on the hours timescale. I will conclude by discussing new fluorescent intrabodies my lab is engineering to light up nascent and mature proteins in multiple colors. As these intrabodies can be encoded on plasmids, they can easily be adapted by other labs to image gene activity in diverse living systems.
Timothy J. Stasevich is an Associate Professor in the Department of Biochemistry and Molecular Biology at Colorado State University (CSU). His lab uses a combination of advanced fluorescence microscopy, genetic engineering, and computational modeling to study the dynamics of gene regulation in living mammalian cells. His lab helped pioneer the imaging of real-time single-mRNA translation dynamics in living cells1. Dr. Stasevich received his B.S. in Physics and Mathematics from the University of Michigan, Dearborn, and his Ph. D. in Physics from the University of Maryland, College Park. He transitioned into experimental biophysics as a post-doctoral research fellow in the laboratory of Dr. James G. McNally at the National Cancer Institute. During this time, he developed technology based on fluorescence microscopy to help establish gold-standard measurements of live-cell protein dynamics. Dr. Stasevich next moved to Osaka University, where he worked with Dr. Hiroshi Kimura as a Japan Society for the Promotion of Science Foreign Postdoctoral Research Fellow. While there, he helped create technology to image endogenous proteins and their post-translation modifications in vivo. This allowed him to image the live-cell dynamics of epigenetic histone modifications during gene activation for the first time2. Before joining the faculty at CSU, Dr. Stasevich spent a year as a Visiting Fellow at the HHMI Janelia Research Campus, where he applied superresolution fluorescence microscopy to improve the spatiotemporal resolution of endogenous protein imaging in live cells.
1. Morisaki, T. et al. Real-time quantification of single RNA translation dynamics in living cells. Science 352, 1425–1429 (2016).
2. Stasevich, T. J. et al. Regulation of RNA polymerase II activation by histone acetylation in single living cells. Nature 516, 272–275 (2014).

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Lecture / Discussion Thu, 30 Sep 2021 10:17:54 -0400 2021-10-18T16:00:00-04:00 2021-10-18T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Tim Stasevich, Colorado State University
LHS Collaboratory (October 19, 2021 12:00pm) https://events.umich.edu/event/87559 87559-21644084@events.umich.edu Event Begins: Tuesday, October 19, 2021 12:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Unlike structured data, unstructured data are often buried within free text clinical narratives that are difficult to analyze and interpret to derive useful insights. Free text cannot be easily categorized in the same way that a structured, numerical data point can, and unstructured data often have nuances that are not easily captured or represented in structured data.

This session will cover methods and techniques for interpreting and converting unstructured text into useful research data using two related, but distinct approaches: (1) Natural Language Processing (NLP), a specialized branch of AI focused on the interpretation and manipulation of human-generated spoken or written data; and (2) information retrieval, which often underlies many search engine technologies. This session will also highlight EMERSE, an open-source information retrieval tool that has been designed to help everyday users work with the free text documents (i.e., clinical notes) in medical records that is now being adopted by other academic medical centers.

Finally, attendees will hear directly from researchers about how they have used these methods and tools to enhance their research by accessing and harnessing the power of unstructured data.

Speakers:
David A. Hanauer, MD, MS, FACMI, FAMIA
Director of MICHR Informatics Program
Associate Professor of Learning Health Sciences


BRINGING DATA TO THE PEOPLE: HOW A SECURE, SELF-SERVICE, FREE-TEXT SEARCH TOOL CAN EMPOWER CLINICAL RESEARCH TEAMS AND IMPROVE PRODUCTIVITY

VG Vinod Vydiswaran, PhD
Associate Professor of Learning Health Sciences
Associate Professor School of Information

PROMISE OF UNSTRUCTURED DATA

Discussants:
Christina Angeles, MD
Assistant Professor, Surgery (General Surgery)
Assistant Professor, Dermatology

Xu Shi, Ph.D.
CCMB Affiliate Faculty
Assistant Professor of Biostatistics, School of Public Health


Leslie Yuan, MPH
Chief Information Officer, Clinical and Translational Science
(CTSI) , University of California San Francisco

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Livestream / Virtual Mon, 27 Sep 2021 11:21:27 -0400 2021-10-19T12:00:00-04:00 2021-10-19T13:30:00-04:00 Off Campus Location Department of Learning Health Sciences Livestream / Virtual Collaboratory logo
Department of Computational Medicine & Bioinformatics Weekly Seminar (October 20, 2021 4:00pm) https://events.umich.edu/event/88315 88315-21652404@events.umich.edu Event Begins: Wednesday, October 20, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

The Ye lab is focused on harnessing the power of single cell and computational genomics to understand how immune cells sense and respond to their environment. Utilizing new experimental methods we have developed to enable multiplexed single-cell sequencing, I will describe results from sequencing 1.2M cells from ~250 samples to understand the cellular and molecular bases of systemic lupus erythmatosus and COVID-19. I will also describe how population scale single cell sequencing can enable dissection of the genetic architecture of gene expression and annotation of disease associated variants. Finally, I’ll touch on novel experimental workflows to further increase the throughput of single-cell genomics and for encoding orthogonal information into single-cell sequencing assays.

Research Overview:

The Ye lab is interested in how the interaction between genetics and environment affect human variation at the level of molecular phenotypes. To study these interactions, the lab couples high-throughput sequencing approaches that measure cellular response under environmental challenges with population genetics where such measurements are collected and analyzed across large patient cohorts. The lab develops novel experimental approaches that enable the large-scale collection of functional genomic data *en masse* and computational approaches that translate the data into novel biological insights. This approach is used to initially study primary human immune cells in both healthy and diseased patients to understand host pathogen interactions and its role in autoimmunity.

Zoom link: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Fri, 15 Oct 2021 14:50:45 -0400 2021-10-20T16:00:00-04:00 2021-10-20T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual
NeuroNetwork for Emerging Therapies Mini Symposium Series: The Mind & Music (October 21, 2021 2:00pm) https://events.umich.edu/event/88351 88351-21653429@events.umich.edu Event Begins: Thursday, October 21, 2021 2:00pm
Location: Off Campus Location
Organized By: NeuroNetwork for Emerging Therapies

"Music is to the mind as air is to the body." (Plato)

The next installment of the NeuroNetwork for Emerging Therapies Mini Symposium Series explores the idea of music as the medicine of the mind, from its physical effects to the emotions it elicits. It culminates with a look at how Mott Children’s Hospital is using music therapy to bring.

When: Thursday, October 21, 2:00 PM-2:30 PM
Where: ZOOM
Register: https://michmed.org/O525W

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Lecture / Discussion Mon, 18 Oct 2021 11:24:57 -0400 2021-10-21T14:00:00-04:00 2021-10-21T14:30:00-04:00 Off Campus Location NeuroNetwork for Emerging Therapies Lecture / Discussion Flier for The Mind & Music
U-M Structure Seminar: “The Structural Basis for Control of Methylation Extent in Polyketide Synthase Metal-dependent C-methyltransferases” (October 22, 2021 10:00am) https://events.umich.edu/event/85433 85433-21626420@events.umich.edu Event Begins: Friday, October 22, 2021 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

Yongtong Lao
Graduate Student
Janet Smith Lab
University of Michigan

Hybrid: LSI Library and Zoom - https://umich.zoom.us/j/97763780708 (Password: structure)

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Workshop / Seminar Mon, 20 Sep 2021 16:31:40 -0400 2021-10-22T10:00:00-04:00 2021-10-22T11:00:00-04:00 Life Sciences Institute U-M Structural Biology Workshop / Seminar U-M Structure
The Trichloroethylene Metabolite S-(1,2-dichlorovinyl)-L-cysteine Suppresses Inflammatory Pathways in a Macrophage Cell Model: Implications for Immunosuppression During Pregnancy (October 26, 2021 12:00pm) https://events.umich.edu/event/88558 88558-21655081@events.umich.edu Event Begins: Tuesday, October 26, 2021 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

https://umich.zoom.us/s/95313929320

The goal of the environmental research seminar/webinar is to provide an interdisciplinary forum for sharing and critiquing research proposals and preliminary study results.

Dr. Harris is a Research Assistant Professor of Environmental Health Sciences in the School of Public Health at the University of Michigan. Dr. Harris earned his PhD in environmental toxicology from the University of Washington, where he conducted his dissertation research in male reproductive toxicology. As part of his research he helped to develop an in vitro testis cell culture model for studying male reproductive toxicants. He now studies female reproductive toxicology, using a combination of approaches including primary tissue culture models, transcriptomics and metabolomics to investigate molecular mechanisms of toxicant effects on the placenta and fetal membranes. His research aims to advance our understanding of how environmental toxicants contribute to adverse pregnancy outcomes.

https://umich.zoom.us/s/95313929320

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Lecture / Discussion Mon, 25 Oct 2021 11:02:57 -0400 2021-10-26T12:00:00-04:00 2021-10-26T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Sean Harris Oct 26 Environmental Research Webinar
Department of Computational Medicine & Bioinformatics Weekly Seminar (October 27, 2021 4:00pm) https://events.umich.edu/event/88276 88276-21652019@events.umich.edu Event Begins: Wednesday, October 27, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:
Molecular classification has transformed the diagnosis and treatment of diffuse gliomas, creating targets for precision therapies. However, timely and efficient access to molecular diagnostic methods remains difficult, causing a significant barrier to deliver molecularly-targeted therapies. We aim to develop an innovative point-of-care diagnostic screening method that provides rapid and accurate molecular classification of diffuse gliomas through artificial intelligence and optical imaging in order to improve the comprehensive care of brain tumor patients.

Bio:
Dr. Todd Hollon is a neurosurgeon and research scientist who specializes in brain tumors. He is an Assistant Professor of Neurosurgery. He completed his postdoctoral training in the UM Translational Molecular Imaging Laboratory under the supervision of Drs. Daniel Orringer and Honglak Lee. His postdoctoral work focused on the application of deep neural networks to advanced imaging methods to improve the speed and accuracy of intraoperative brain tumor diagnosis. He hopes to be part of the next generation of young scientists that uses computation and machine learning to make scientific breakthroughs.

Host: Josh Welch, PhD

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

In-Person: Forum Hall, Palmer Commons

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Livestream / Virtual Thu, 14 Oct 2021 14:26:31 -0400 2021-10-27T16:00:00-04:00 2021-10-27T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual
STEM Research Career Award (October 27, 2021 4:00pm) https://events.umich.edu/event/87133 87133-21639078@events.umich.edu Event Begins: Wednesday, October 27, 2021 4:00pm
Location: Off Campus Location
Organized By: Office of National Scholarships & Fellowships (ONSF)

Register here: https://myumi.ch/O4eKQ

The U-M STEM Research Career Award supports highly qualified students who plan to pursue a PhD and research career in a STEM field.

The scholarship provides $5000 for summer research or other academic expenses. The scholarship does not require US citizenship; it is open to students from all nationalities and backgrounds. The U-M STEM Research Career Award application and letters of recommendation will also be used to select U-M’s nominees for the Goldwater and Astronaut Scholarships from among eligible applicants.

Learn more: https://lsa.umich.edu/onsf/scholarships/stem-biomedical/u-m-stem-research-career-award.html

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Livestream / Virtual Tue, 19 Oct 2021 13:30:18 -0400 2021-10-27T16:00:00-04:00 2021-10-27T17:00:00-04:00 Off Campus Location Office of National Scholarships & Fellowships (ONSF) Livestream / Virtual Chemical engineers develop clean energy storage solutions
“Disparities in Reproductive Aging & Midlife Health between Black & White Women” and “Taking Action to Advance the Study of Race & Ethnicity” (October 28, 2021 4:00pm) https://events.umich.edu/event/87494 87494-21642885@events.umich.edu Event Begins: Thursday, October 28, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for Midlife Science

Please register for more information and Zoom link.
https://umich.zoom.us/webinar/register/WN_JiZPRVJaStK7yNbArsSubA

The webinar, hosted by the Center for Midlife Science, features papers that will appear in a special series for the journal, Women's Midlife Health.

Talk #1 “Disparities in Reproductive Aging and Midlife Health between Black and White Women: Study of Women’s Health Across the Nation (SWAN)” with Tené T. Lewis, PhD, Department of Epidemiology, Emory University; and Siobán D. Harlow, PhD, Department of Epidemiology, University of Michigan.

Talk #2: “Taking Action to Advance the Study of Race and Ethnicity: The Women’s Health Initiative (WHI)” with Shawna Follis, PhD, MS (Dept. of Medicine, Stanford Univ. School of Medicine); Monik C. Jiménez, ScD, SM, FAHA, (Harvard Medical School and T.H. Chan School of Public Health); and Lorena Garcia, MPH, DrPH, (Division of Epidemiology, Dept. of Public Health Sciences, UC Davis School of Medicine).

Moderators: Sherri-Ann M. Burnett-Bowie, MD, MPH, Department of Medicine, Massachusetts General Hospital & Harvard Medical School; and Gloria Bachmann, MD, Rutgers Robert Wood Johnson Medical School.

Sponsored by the journal, Women’s Midlife Health; Center for Midlife Science at the University of Michigan's School of Public Health; Massachusetts General Hospital Department of Medicine Diversity and Inclusion Board. SWAN is funded by the National Institute of Aging, the National Institute of Nursing Research and the Office of Research on Women's Health. WHI is funded by the National Heart, Lung and Blood Institute.

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Lecture / Discussion Fri, 24 Sep 2021 12:04:41 -0400 2021-10-28T16:00:00-04:00 2021-10-28T17:00:00-04:00 Off Campus Location Center for Midlife Science Lecture / Discussion Webinar Series on Structural Racism and Midlife Health
Methods for estimating time-varying exposures during pregnancy and adverse birth outcomes (November 1, 2021 12:00pm) https://events.umich.edu/event/88560 88560-21655083@events.umich.edu Event Begins: Monday, November 1, 2021 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Howard Chang, PhD, is a Professor of Biostatistics, Bioinformatics and Environmental Health in the Rollins School of Public Health at Emory University.

The goal of Environmental Statistics Week is to disseminate knowledge of advanced statistical methods most relevant to environmental health research with expert-led discussions on statistical concepts.

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Lecture / Discussion Fri, 22 Oct 2021 16:27:34 -0400 2021-11-01T12:00:00-04:00 2021-11-01T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion 2021 Environmental Statistics Week
RISE November Virtual Talking Circle (November 1, 2021 12:00pm) https://events.umich.edu/event/87910 87910-21647679@events.umich.edu Event Begins: Monday, November 1, 2021 12:00pm
Location: Off Campus Location
Organized By: RISE (Research. Innovation. Scholarship. Education.)

Please join us for our next Virtual Taking Circle on Monday, November 1 at 12:00 PM. We will be hosting a conversation about how educators are finding ways to innovate within the clinical setting. We look forward to learning more about current innovations happening in the clinical setting and what it takes to be innovative within this setting. We will also explore synergies that might better enable innovation and what is next for innovation in the clinical setting.
All are welcome to join!

Register via Eventbrite: https://www.eventbrite.com/e/rise-virtual-talking-circle-tickets-176292163607

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Workshop / Seminar Tue, 05 Oct 2021 12:17:38 -0400 2021-11-01T12:00:00-04:00 2021-11-01T13:00:00-04:00 Off Campus Location RISE (Research. Innovation. Scholarship. Education.) Workshop / Seminar RISE Virtual Talking Circle
Bayesian models for mercury effects on multiple outcomes in the Seychelles Child Development Study (November 2, 2021 12:00pm) https://events.umich.edu/event/88561 88561-21655084@events.umich.edu Event Begins: Tuesday, November 2, 2021 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Sally W. Thurston, PhD is an Associate Professor of Biostatistics and Environmental Medicine, University of Rochester, Dept of Biostatistics and Computational Biology.

ABSTRACT: The Seychelles Child Development Study (SCDS) Main Cohort was recruited to investigate the association between prenatal mercury (Hg) exposure from maternal fish consumption and the children’s subsequent development. Multiple neurodevelopmental outcomes were measured at several discrete ages. These outcomes can be grouped into different classes or "domains", such as cognition, motor, or memory. Associations of Hg and covariates may differ across outcomes and domains. Motivated by the SCDS, I will first discuss a model for multiple outcomes at a single age under the assumption that each outcome belongs to one domain and domain memberships are known. I will then briefly describe two extensions: a model in which outcomes may have partial domain membership in more than one domain, and a longitudinal multiple outcomes model for cognition when the tests of cognition change with the age of the child.

The goal of Environmental Statistics Week is to disseminate knowledge of advanced statistical methods most relevant to environmental health research with expert-led discussions on statistical concepts.

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Lecture / Discussion Fri, 22 Oct 2021 16:34:57 -0400 2021-11-02T12:00:00-04:00 2021-11-02T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion 2021 Environmental Statistics Week
How close and how much? Linking health outcomes to spatial distributions of built environment features (November 3, 2021 12:00pm) https://events.umich.edu/event/88562 88562-21655085@events.umich.edu Event Begins: Wednesday, November 3, 2021 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Veronica Berrocal, PhD, is an Associate Professor in the Department of Statistics, University of California at Irvine.

Built environment features (BEFs) refer to aspects of the human constructed environment, which may in turn support or restrict health related behaviors and thus impact health. In this talk we are interested in understanding whether the spatial distribution and quantity of fast food restaurants (FFRs) influence the risk of obesity in schoolchildren. Our analysis on the influence of patterns of FFR occurrence on obesity among Californian schoolchildren has indicated that, in 2010, among schools that are consistently assigned to a cluster, there is a lower odds of obesity amongst 9th graders who attend schools with most distant FFR occurrences in a 1-mile radius as compared to others.

The goal of Environmental Statistics Week is to disseminate knowledge of advanced statistical methods most relevant to environmental health research with expert-led discussions on statistical concepts.

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Lecture / Discussion Fri, 22 Oct 2021 16:42:53 -0400 2021-11-03T12:00:00-04:00 2021-11-03T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion 2021 Environmental Statistics Week
Department of Computational Medicine & Bioinformatics Weekly Seminar (November 3, 2021 4:00pm) https://events.umich.edu/event/88449 88449-21654119@events.umich.edu Event Begins: Wednesday, November 3, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract
My research group works in the area of mathematical oncology, where we use mathematical models to decipher the complex networks of reactions inside of cancer cells and interactions between cells. Immune cells use hundreds of biochemical reactions to respond to their environment, become activated, and kill cancer cells. Understanding the complexity of these reaction networks requires computational tools and mathematical models. We combine detailed, mechanistic modeling with machine learning to study these networks, better understand cancer and immune cells, and predict ways to control tumor growth. In this talk, I will present our recent work aimed at predicting the dynamics of immune cell behaviors across three scales: intracellular signaling pathways in CAR T cells, the collective behavior of a heterogeneous population of immune cells, and tumor-immune interactions at the tissue scale. Our models generate novel mechanistic insight into immune cell activation and predict the effects of immunotherapeutic strategies.


Biography
Stacey D. Finley is the Gordon S. Marshall Early Career Chair and Associate Professor of Biomedical Engineering at the University of Southern California. Dr. Finley received her B.S. in Chemical Engineering from Florida A & M University and obtained her Ph.D. in Chemical Engineering from Northwestern University. She completed postdoctoral training at Johns Hopkins University in the Department of Biomedical Engineering. Dr. Finley joined the faculty at USC in 2013, and she leads the Computational Systems Biology Laboratory. Dr. Finley has joint appointments in the Departments of Chemical Engineering and Materials Science and Quantitative and Computational Biology, and she is a member of the USC Norris Comprehensive Cancer Center. Dr. Finley is also the Founding Director of the Center for Computational Modeling of Cancer at USC. Her research is supported by grants from NSF, NIH, and the American Cancer Society.

Selected honors. 2016 NSF Faculty Early CAREER Award; 2016 Young Innovator by the Cellular and Molecular Bioengineering journal; Leah Edelstein-Keshet Prize from the Society of Mathematical Biology; Junior Research Award from the USC Viterbi School of Engineering; the Hanna Reisler Mentorship Award; 2018 AACR NextGen Star; 2018 Orange County Engineering Council Outstanding Young Engineer; Elected Fellow of the American Institute for Medical and Biological Engineering (2021)

Hosted by: Alan Boyle, PhD

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Wed, 20 Oct 2021 09:54:50 -0400 2021-11-03T16:00:00-04:00 2021-11-03T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual Stacey D. Finley, Ph.D. (USC)
DUP Lectures: Insights Into Distinguished Careers (November 3, 2021 4:00pm) https://events.umich.edu/event/88306 88306-21652308@events.umich.edu Event Begins: Wednesday, November 3, 2021 4:00pm
Location: Michigan League
Organized By: Department of History

In 1947 the Regents established the Distinguished University Professorships, the University’s most prestigious professorships, to recognize senior faculty with exceptional scholarly and/or creative achievements, national and international reputations for academic excellence, and superior records of teaching, mentoring, and service. Faculty selected for this recognition, in consultation with the dean of the school or college in which he or she holds an appointment, name the Professorship after a person of distinction in his or her general field of interest, preferably a person formerly associated with the University.

This year's DUP lectures will include John Z. Ayanian, Earl Lewis, and Janet L. Smith.

This event will take place in the Michigan League, and will be streamed live on YouTube here: https://www.youtube.com/watch?v=xPSZXLIn-_U

The Quest for Health Equity
John Z. Ayanian, Alice Hamilton Distinguished University Professor of Medicine and Healthcare Policy, Professor of Internal Medicine, Medical School; Professor of Health Management and Policy, School of Public Health; Professor of Public Policy, Gerald R. Ford School of Public Policy; Director, Institute for Healthcare Policy and Innovation

How Questions of Power, Race and Identity Shaped a Career
Earl Lewis, Thomas C. Holt Distinguished University Professor of History, Afroamerican and African Studies, and Public Policy, Professor of History, Professor of Afroamerican and African Studies, College of Literature, Science, and the Arts;
Professor of Public Policy, Gerald R. Ford School of Public Policy

A Path to Discovering Biology in Protein Structure
Janet L. Smith, Martha L. Ludwig Distinguished University Professor of Biological Chemistry, Medical School; Margaret J. Hunter Collegiate Professor in the Life Sciences, Associate Director, Life Sciences Institute, Professor of Biophysics, College of Literature, Science, and the Arts

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Lecture / Discussion Mon, 18 Oct 2021 11:22:09 -0400 2021-11-03T16:00:00-04:00 2021-11-03T18:00:00-04:00 Michigan League Department of History Lecture / Discussion
What do we learn from the environmental surveillance of SARS-CoV-2 on and off campus? (November 4, 2021 12:00pm) https://events.umich.edu/event/88563 88563-21655086@events.umich.edu Event Begins: Thursday, November 4, 2021 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Chuanwu Xi, PhD, is a Professor of Environmental Health Sciences and Global Public Health in the School of Public Health, University of Michigan.

The goal of Environmental Statistics Week is to disseminate knowledge of advanced statistical methods most relevant to environmental health research with expert-led discussions on statistical concepts.

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Lecture / Discussion Fri, 22 Oct 2021 16:48:21 -0400 2021-11-04T12:00:00-04:00 2021-11-04T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion 2021 Environmental Statistics Week
How much evidence do you need? Data Science to Inform Environmental Policy During the COVID-19 Pandemic (November 5, 2021 12:00pm) https://events.umich.edu/event/88564 88564-21655087@events.umich.edu Event Begins: Friday, November 5, 2021 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Francesca Dominici, PhD, is Professor of Biostatistics at the Harvard T.H. Chan School of Public Health and Co-Director of the Data Science Initiative at Harvard University.

The goal of Environmental Statistics Week is to disseminate knowledge of advanced statistical methods most relevant to environmental health research with expert-led discussions on statistical concepts.

Registration required. https://umich.zoom.us/s/96276431694

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Lecture / Discussion Thu, 04 Nov 2021 13:50:04 -0400 2021-11-05T12:00:00-04:00 2021-11-05T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion 2021 Environmental Statistics Week
RNA Innovation Seminar (November 8, 2021 4:00pm) https://events.umich.edu/event/86167 86167-21631759@events.umich.edu Event Begins: Monday, November 8, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

"Harnessing diverse compact CRISPR-Cas3 for long-range genome engineering"
Zhonggang Hou, Ph.D.
Research Investigator
Biological Chemistry

and

"Microscopic Examination of Spatial Transcriptome through Seq-Scope"
Jun Hee Lee, PhD
Associate Professor
Molecular & Integrative Physiology

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Lecture / Discussion Mon, 25 Oct 2021 13:33:17 -0400 2021-11-08T16:00:00-05:00 2021-11-08T20:00:00-05:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Zhonggang Hou, Biological Chemistry & Jun Hee Lee, Molecular & Integrative Physiology
Per- and Polyfluoroalkyl Substances (PFAS) and Women’s Reproductive Health: Findings from the Study of Women’s Health Across the Nation (SWAN) (November 9, 2021 12:00pm) https://events.umich.edu/event/88884 88884-21658815@events.umich.edu Event Begins: Tuesday, November 9, 2021 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

https://umich.zoom.us/s/97831201308

Dr. Ding is a postdoctoral research fellow focusing on environmental epidemiology in the Department of Epidemiology, School of Public Health, University of Michigan.

The goal of the environmental research seminar/webinar is to provide an interdisciplinary forum for sharing and critiquing research proposals and preliminary study results.

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Lecture / Discussion Tue, 02 Nov 2021 10:04:20 -0400 2021-11-09T12:00:00-05:00 2021-11-09T12:50:00-05:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Ning Ding ER Seminar (11-09-2021)
Department of Computational Medicine & Bioinformatics Weekly Seminar (November 10, 2021 4:00pm) https://events.umich.edu/event/88540 88540-21654960@events.umich.edu Event Begins: Wednesday, November 10, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

Subspace classifiers have been around for a long time, beginning with feature selection, which in essence was a subspace selection technique. This talk will discuss the kind of subspace classifiers that Bledsoe and Browning presented in their 1959 paper and from which there have been a variety of extensions which we will discuss.

The Bledsoe and Browning subspace classifier quantizes measurement space. Each quantized observation tuple corresponds to a cell in measurement space. A collection of subspaces are selected at random. In the original form the subspaces were mutually exclusive. For each class, each cell of a subspace contained a number dependent on the number of observations of the training data that fell into that cell. For each class those numbers were combined in ways not dissimilar to random forests. For a given observation tuple, the class with the highest vote count was selected as the assigned class.

We will discuss a variety of principled extensions of the technique and make some comparisons with Neural Networks.

Research Interests:

High-dimensional space clustering, pattern recognition, knowledge discovery and artificial intelligence

Professor Haralick began his work as one of the principal investigators of the NASA ERTS satellite data doing remote sensing image analysis.

He has made a series of contributions in the field of computer vision. In the high-level vision area, he has worked on inferring 3D geometry from one or more perspective projection views.] He has also identified a variety of vision problems which are special cases of the consistent labeling problem. His papers on consistent labeling, arrangements, relation homomorphism, matching, and tree search translate some specific computer vision problems to the more general combinatorial consistent labeling problem and then discuss the theory of the look-ahead operators that speed up the tree search. The most basic of these is called Forward Checking. This gives a framework for the control structure required in high-level vision problems. He has also extended the forward-checking tree search technique to propositional logic.

Zoom: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Fri, 22 Oct 2021 09:28:27 -0400 2021-11-10T16:00:00-05:00 2021-11-10T17:00:00-05:00 Off Campus Location DCMB Seminar Series Livestream / Virtual Robert M. Haralick, PhD (City University of New York)
LSI Seminar Series: Björn Hamberger, Ph.D., Michigan State University (November 11, 2021 12:00pm) https://events.umich.edu/event/88795 88795-21657769@events.umich.edu Event Begins: Thursday, November 11, 2021 12:00pm
Location: Off Campus Location
Organized By: Life Sciences Institute (LSI)

*Abstract:*
Plant specialized products have co-evolved over 450 million years with their enemies: pests, pathogens and feeding animals. Terpenes specifically are a hallmark of effective plant defense, yet humans have also discovered their value as flavors, fragrances, cosmetics and therapeutics since the dawn of civilization. In modern times, natural products represent for the industry the entire spectrum of compounds from green solvents to agrichemicals and high-value antibiotics and pharmaceuticals. Instead of using inherently petrol-based, formal chemical synthesis for their access, our team is interested in learning from plants how these compounds are made and in exploring the plant routes for biotechnological applications. The knowledge is already empowering new approaches to explore the uncharted territory of their chemistries for biosustainable production.

This talk will highlight highly diverse endeavors and the challenges tackled by the students on our team. Specifically, we were hunting pathways to the plant-based drugs ingenol (anti-cancer), triptolide (immunomodulatory, anti-viral) and forskolin (silver-bullet drug). This research has revealed non-canonical enzymatic steps, unusual substrates and unexpected promiscuity. Plant species we are excited about are increasing on a nearly weekly basis, but we are currently focusing on members of the coffee (Rubiaceae) and mint (Lamiaceae) families. New technical advances (sequencing, analytics) have already changed the traditional ways we approach these plants. A few key features make the work particularly exciting for of our team: diverse collaborations bridging phytochemistry, biochemistry, molecular biology, bioinformatics and engineering of biotech host species. Collectively, this represents one of the many facets of synthetic biology.

*About the Speaker*
With a background in chemistry, the training of Björn Hamberger expands from biochemistry and molecular biology to plant synthetic biology. The research of his team, established in 2016 at Michigan State University, approaches the discovery of plant pathways in non-model medicinal plants accumulating bioactive specialized metabolites with pharmacological activities and their biotechnological production. The publication record of Hamberger’s team highlights an interdisciplinary and highly cooperative research, with top-tier international journals, including contributions since 2016 to Science, PNAS, Angewandte Chemie, International Edition, eLife, Nature Communications, New Phytologist, the Journal of Biochemistry and the Plant Journal. His work, supported by two distinct MSU Strategic Partnership Programs has also yielded three Patent Applications. Hamberger's applied and technologically broad research approach also has been integrated in his teaching and mentoring efforts for undergraduate students, graduates and postdoctoral members of the team.

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Lecture / Discussion Fri, 29 Oct 2021 14:51:51 -0400 2021-11-11T12:00:00-05:00 2021-11-11T13:00:00-05:00 Off Campus Location Life Sciences Institute (LSI) Lecture / Discussion LSI Seminar Series
DCMB / CCMB Weekly Seminar Series (November 17, 2021 4:00pm) https://events.umich.edu/event/89137 89137-21660643@events.umich.edu Event Begins: Wednesday, November 17, 2021 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Talk title: Clinical Trajectory analysis to determine risk-factors of Copd: A COPDGene Study

Abstract:

Background

Chronic obstructive pulmonary disease (COPD) presents significant clinical heterogeneity and a wide variety of progression trajectories [1]. Clinical trajectory analysis (ClinTrajAn) is a powerful tool based on elastic principal graphs for the calculation of trajectories from large cross-sectional clinical data sets [2].

Aims and objectives

Our objective was to determine potential risk-factors by evaluate progression trajectories in COPD using ClinTrajAn on the COPDGene Phase I (baseline visit) dataset.

Methods

7883 participants, current and former smokers with GOLD 0 thru 4 COPD, from Phase I of the COPDGene study, were utilized for this work. 55 features were obtained for each subject, including demographics, spirometry, smoking history and computed tomography (CT), which included Parametric Response Mapping (PRM). Developed by our group, PRM is capable of simultaneously measuring small airways disease and emphysema which are the main contributors of airflow limitations in COPD. The resulting data matrix was analyzed with ClinTrajAn.

Results

A principal tree, with 13 branch segments and 8 termini, was generated (Figure 1). There was a clearly recognized trajectory from healthier subjects through decreasing lung function and increasing age (Figure 1 A), increasing in GOLD (Figure 1 B), to an emphysema high terminus (Figure 1 C). Notably this method illustrated numerous branching points along this trajectory.

Conclusions

In this study we used ClinTrajAn to obtain a map of disease progression trajectories in COPD including clinically recognized pathogenesis. Our next steps will be to further validate this approach using longitudinal data from the COPDGene follow-up visits.

References

1. Han MK, Agusti A, Calverley PM, Celli BR, Criner G, Curtis JL, Fabbri LM, Goldin JG, Jones PW, MacNee W, Make BJ. Chronic obstructive pulmonary disease phenotypes: the future of COPD. American journal of respiratory and critical care medicine. 2010 Sep 1;182(5):598-604.

2. Golovenkin SE, Bac J, Chervov A, Mirkes EM, Orlova YV, Barillot E, Gorban AN, Zinovyev A. Trajectories, bifurcations, and pseudo-time in large clinical datasets: applications to myocardial infarction and diabetes data. GigaScience. 2020 Nov;9(11):giaa128.

Zoom link: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Lecture / Discussion Wed, 10 Nov 2021 09:47:40 -0500 2021-11-17T16:00:00-05:00 2021-11-17T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
Medical School Student Panel Discussion (November 18, 2021 3:30pm) https://events.umich.edu/event/85497 85497-21626705@events.umich.edu Event Begins: Thursday, November 18, 2021 3:30pm
Location: Off Campus Location
Organized By: Science Learning Center

Here is your chance to hear about what life is like for several medical school students and residents. Learn about each of their paths to medicine, experiences in medical school, and things they wished they had known in college. You can also submit your own questions ahead of time using the following link: https://myumi.ch/2D299

Register on Sessions: https://myumi.ch/pdYmj

Email ScienceSuccessSeries@umich.edu with any questions.

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Workshop / Seminar Fri, 20 Aug 2021 11:59:04 -0400 2021-11-18T15:30:00-05:00 2021-11-18T17:00:00-05:00 Off Campus Location Science Learning Center Workshop / Seminar
U-M Structure Seminar: "Strategies to minimize beam-induced motion in Cryo-EM data collection" (November 19, 2021 10:00am) https://events.umich.edu/event/86436 86436-21634313@events.umich.edu Event Begins: Friday, November 19, 2021 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

Min Su, Ph.D.
Cryo-EM Resource Director
University of Michigan

Laura Koepping
Cryo-EM Research Specialist
University of Michigan

Hybrid: LSI Library and Zoom - https://umich.zoom.us/j/97763780708 (Password: structure)

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Workshop / Seminar Tue, 02 Nov 2021 16:06:42 -0400 2021-11-19T10:00:00-05:00 2021-11-19T11:00:00-05:00 Life Sciences Institute U-M Structural Biology Workshop / Seminar U-M Structure
Alan J. Hunt Memorial Lecture: "Moving takes energy: the intersection of cell motility with cellular metabolism" (November 19, 2021 2:00pm) https://events.umich.edu/event/89276 89276-21661669@events.umich.edu Event Begins: Friday, November 19, 2021 2:00pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: Biomedical Engineering

2021 Alan J. Hunt Memorial Lecture

"Moving takes energy: the intersection of cell motility with cellular metabolism"

Cynthia Reinhart-King, Ph.D.
Cornelius Vanderbilt Professor of Engineering
Professor of Biomedical Engineering
Vanderbilt University

November 19, 2021, 2:00 PM - 3:30 PM

Please save the date and RSVP below for the 2021 Alan J. Hunt Memorial Lecture on Friday, November 19, 2021, from 2:00 PM - 3:30 PM. The lecture will take place in 1130 Lurie Biomedical Engineering Building (classroom) featuring Cynthia Reinhart-King, Ph.D. the Cornelius Vanderbilt Professor of Engineering and Professor of Biomedical Engineering at Vanderbilt University. Following the lecture, a reception will be held in the BME Commons.

Details:
DATE: Friday, November 19, 2021
TIME: 2:00 PM - 3:30 PM (Reception; 3:30 PM - 4:30 PM)
LOCATION: 1130 Lurie Biomedical Engineering; A reception will follow in the BME Commons

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Lecture / Discussion Mon, 15 Nov 2021 15:16:23 -0500 2021-11-19T14:00:00-05:00 2021-11-19T16:30:00-05:00 Lurie Biomedical Engineering (formerly ATL) Biomedical Engineering Lecture / Discussion Alan J Hunt
Sustaining a Healthy Nail Salon Workforce in Michigan (November 23, 2021 12:00pm) https://events.umich.edu/event/89270 89270-21661657@events.umich.edu Event Begins: Tuesday, November 23, 2021 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Registration required
https://umich.zoom.us/s/98595068138

Aurora Le, PhD, MPH, CPH, CSP (John G. Searle Assistant Professor of Environmental Health Sciences, School of Public Health, University of Michigan) and Marie-Anne Rosemberg, PhD, MN, RN, FAAOHN (Assistant Professor, Dept. of Systems, Populations and Leadership, School of Nursing, University of Michigan), co-lead the Michigan Healthy Nail Salon Cooperative. The goal of the environmental research seminar/webinar is to provide an interdisciplinary forum for sharing and critiquing research proposals and preliminary study results.

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Lecture / Discussion Mon, 15 Nov 2021 13:38:28 -0500 2021-11-23T12:00:00-05:00 2021-11-23T12:50:00-05:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Nov 30 Environmental Research Webinar
Department of Computational Medicine & Bioinformatics Weekly Seminar (December 1, 2021 4:00pm) https://events.umich.edu/event/88514 88514-21654664@events.umich.edu Event Begins: Wednesday, December 1, 2021 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract:

Epigenetic control of gene expression is highly cell-type- and context-specific. Yet, despite its complexity, gene regulatory logic can be broken down into modular components consisting of a transcription factor (TF) activating or repressing the expression of a target gene through its binding to a cis-regulatory region. Recent advances in joint profiling of transcription and chromatin accessibility with single-cell resolution offer unprecedented opportunities to interrogate such regulatory logic. Here, we propose a nonparametric approach, TRIPOD, to detect and characterize three-way relationships between a TF, its target gene, and the accessibility of the TF’s binding site, using single-cell RNA and ATAC multiomic data. We apply TRIPOD to interrogate cell-type-specific regulatory logic in peripheral blood mononuclear cells and contrast our results to detections from enhancer databases, cis-eQTL studies, ChIP-seq experiments, and TF knockdown/knockout studies. We then apply TRIPOD to mouse embryonic brain data during neurogenesis and gliogenesis and identified known and novel putative regulatory relationships, validated by ChIP-seq and PLAC-seq. Finally, we demonstrate TRIPOD on SHARE-seq data of differentiating mouse hair follicle cells and identify lineage-specific regulation supported by histone marks for gene activation and super-enhancer annotations.

Hosted by: Joshua Welch, PhD

Speaker will be in-person and the seminar will be live-streamed via Zoom.

Zoom: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Lecture / Discussion Thu, 21 Oct 2021 14:55:35 -0400 2021-12-01T16:00:00-05:00 2021-12-01T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion Yuchao Jiang (Assistant Professor in the Departments of Biostatistics and Genetics at UNC)
"Hybrid Models to Accelerate Discovery and Optimize Design in Neural Engineering" (December 2, 2021 4:00pm) https://events.umich.edu/event/89543 89543-21664063@events.umich.edu Event Begins: Thursday, December 2, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Abstract:
Neural engineers try to fight disease by interfacing directly with the nervous system to correct or circumvent the pathology, but the complexities of neurophysiology make designing these therapies very difficult. The sophisticated interactions of neural control systems with the body and mind has limited our ability to predict the effects of neural interfaces in advance, which forces the field to rely on painstaking animal experiments to test and design the devices. This work presents an alternate way forward using new functionally predictive hybrid models that let us prototype and test neural interfaces in cheap, low-risk settings to get the most out of the cumbersome and expensive animal and human studies that require implanted electrodes. The key innovation is to combine parts of traditionally separate model systems (animal, human, mathematical, or statistical) into hybrid frameworks that use the strengths of each type to make accurate, use-case predictions about the effects of new neural interfaces.
Details:
DATE: Thursday, December 2, 2021
TIME: 4:00-5:00 pm
LOCATION: Cooley G906
ZOOM LINK: https://umich.zoom.us/j/97723483179

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Lecture / Discussion Mon, 29 Nov 2021 09:57:50 -0500 2021-12-02T16:00:00-05:00 2021-12-02T17:00:00-05:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Event
U-M Structure Seminar: "Structural studies of JuvEV modular polyketide synthase" (December 3, 2021 10:00am) https://events.umich.edu/event/86440 86440-21634315@events.umich.edu Event Begins: Friday, December 3, 2021 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

Sean Newmister, Ph.D.
Research Investigator
University of Michigan, Sherman Lab

Hybrid: LSI Library and Zoom - https://umich.zoom.us/j/97763780708 (Password: structure)

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Workshop / Seminar Fri, 19 Nov 2021 11:43:36 -0500 2021-12-03T10:00:00-05:00 2021-12-03T11:00:00-05:00 Life Sciences Institute U-M Structural Biology Workshop / Seminar U-M Structure
RISE December Virtual Talking Circle (December 6, 2021 12:00pm) https://events.umich.edu/event/87913 87913-21647681@events.umich.edu Event Begins: Monday, December 6, 2021 12:00pm
Location: Off Campus Location
Organized By: RISE (Research. Innovation. Scholarship. Education.)

Please join us for our next Virtual Taking Circle on Monday, December 6 at 12:00 PM. We will be hosting a conversation about how educators are finding ways to innovate within the laboratory setting. We look forward to learning more about current innovations happening in the laboratory setting and what it takes to be innovative within this setting. We will also explore synergies that might better enable innovation and what is next for innovation in the laboratory setting.

All are welcome to join!

Register via Eventbrite https://www.eventbrite.com/e/rise-virtual-talking-circle-tickets-177410468487

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Workshop / Seminar Tue, 05 Oct 2021 12:29:32 -0400 2021-12-06T12:00:00-05:00 2021-12-06T13:00:00-05:00 Off Campus Location RISE (Research. Innovation. Scholarship. Education.) Workshop / Seminar RISE Virtual Talking Circle
SCSAP Monthly Seminar Series (December 6, 2021 1:00pm) https://events.umich.edu/event/89632 89632-21664587@events.umich.edu Event Begins: Monday, December 6, 2021 1:00pm
Location: Off Campus Location
Organized By: Single Cell Spatial Analysis Program (SCSAP)

Title: The mutational landscape and clonal dynamics of Human Somatic and Germline cells

During the course of a lifetime normal human cells accumulate mutations. Studying these mutations provides important insight into the development, maintenance and structure of normal tissues, the mutational processes that have been operative, and the role of selection in shaping cell populations. It can elucidate how each of these are altered by, or contribute to, cancer, other diseases, and ageing. However, characterising such mutations has been technically challenging, as normal cell populations consist of myriad small clones, with the mutations differing between clones. We employed laser capture microscopy combined with low input-DNA whole genome sequencing, to study clonal units across multiple cell types from the same individuals. We compared the mutational landscape in 29 cell types from the soma and germline. Our results revealed the extent of variation in clonal dynamics across tissues. Mutation rates vary between different cell types, with stem cells of the intestinal epithelium exhibiting the highest mutation rates and germ-cells in testis exhibited the lowest mutation rates thus far reported. Several mutational signatures were observed among normal cell types. However, most mutations in almost all cell types were due to SBS1 and SBS5, which are likely due to endogenous mutagenic processes. The relative contributions of these signatures differed between cell types, indicating that their rates of generation are, at least partially, independently regulated.

Register on Zoom at https://tinyurl.com/b59rmbk6

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Workshop / Seminar Tue, 30 Nov 2021 16:22:15 -0500 2021-12-06T13:00:00-05:00 2021-12-06T14:00:00-05:00 Off Campus Location Single Cell Spatial Analysis Program (SCSAP) Workshop / Seminar Dr. Raheleh Rahbari, Sanger Institute
LHS Collaboratory (December 7, 2021 12:30pm) https://events.umich.edu/event/88230 88230-21651558@events.umich.edu Event Begins: Tuesday, December 7, 2021 12:30pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Julia Adler-Milstein, PhD
Professor of Medicine and Director of the Center for Clinical Informatics and Improvement Research (CLIIR)
University of California San Francisco

Interoperability is considered a key capability of a high-performing healthcare system and has been a top policy priority for more than a decade. Implementing interoperability is, however, a complex undertaking – requiring stakeholder coordination that tackles incentives, governance, technology, standards, and more. In this talk, Dr. Adler-Milstein will describe current approaches to interoperability and where we stand with respect to current levels of national adoption. She will then discuss the implications for Learning Health System efforts at different levels of scale.

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Livestream / Virtual Wed, 13 Oct 2021 13:59:31 -0400 2021-12-07T12:30:00-05:00 2021-12-07T14:00:00-05:00 Off Campus Location Department of Learning Health Sciences Livestream / Virtual Collaboratory logo
BME PhD Defense: Melissa Lemke (December 8, 2021 1:00pm) https://events.umich.edu/event/89542 89542-21664062@events.umich.edu Event Begins: Wednesday, December 8, 2021 1:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Department of Biomedical Engineering Final Oral Examination

Melissa Lemke

A Systems Approach to Elucidate Personalized Mechanistic Complexities of Antibody-Fc Receptor Activation Post-Vaccination

One of the most significant challenges to current human healthcare is the emergence of antigenically variable viruses that evade traditional vaccination approaches. Human immunodeficiency virus (HIV) is one such virus that emerged over 30 years ago and still has no effective vaccine. Like many other antigenically variable viruses, after infection, HIV quickly mutates to evade broadly neutralizing antibodies that bind tightly to key sites to prevent infection. Over 250 clinical trials have been performed to date to develop an effective HIV vaccine, with only one providing moderate protection; the RV144 Thai trial, estimated to be 31% effective but has not been replicated in other populations. Rather than broadly neutralizing antibodies, the trial identified IgG antibodies with the capacity to induce Fc effector functions as a correlate of protection. These functions are triggered by less specific antibodies that bind HIV antigen and Fc receptors on the surface of innate immune cells to form immune complexes to activate protective cellular functions. Understanding how to increase the formation of IgG-FcR complexes may improve vaccine efficacy, but variation in IgG and FcR features across individuals suggests that protective mechanisms need to be understood on a personalized basis. There are multiple subclasses of protective IgGs, each having different concentrations and affinities to FcRs in different individuals. Genetics can also play a role, with FcR polymorphisms changing FcR binding affinity and IgG1 allotypes changing IgG subclass concentrations. Mechanistic ordinary differential equation (ODE) modeling of this system offers the opportunity to account for these factors on a personalized basis and deconvolve which are most influential and determine how to improve protection universally.


We developed an ODE model of IgG-FcγRIIIa immune complex formation to elucidate how personalized variability in IgG subclass concentration and genetic factors may contribute to complex formation after vaccination. We validated the model with RV144 plasma samples and used it to discover new mechanisms that underpin complex formation. This enabled the identification of genetic and post-translational features that influenced complex formation and suggested the best interventions on a personalized basis. For example, although IgG3 was associated with protection in RV144 and has the highest affinity to FcγRIIIas, the model suggested that IgG1 may play a more essential role, though it also may be highly variable; due to high IgG1 concentration variability across individuals. The model identified RV144 vaccinees who were predicted to be sensitive, insensitive, or negatively affected by increases in HIV-specific IgG1, which was validated experimentally with the addition of HIV-specific IgG1 monoclonal antibodies to vaccine samples. The model also gave important insights into how to maximize IgG-FcγRIIIa complex formation in different genetic backgrounds. We found that individuals with certain IgG1 allotypes were predicted to be more responsive to vaccine adjuvant strategies that increase antibody affinity (e.g., glycosylation modifications) compared to other allotypes, which were predicted to be more responsive to vaccine boosting regimens that increase IgG1 antibody concentration. Finally, simulations in mixed-allotype populations suggest that the benefit of boosting IgG1 concentration versus IgG1 affinity may depend upon the frequency of a specific IgG1 allotype (G1m-1,3) in the population. Overall we believe that this approach represents a valuable tool that will help understand the role of personalized immune mechanisms in response to vaccination and address challenges related to under-represented genetic populations in vaccine trials.

Date: Wednesday, December 8, 2021
Time: 1:00 PM
Zoom: https://umich.zoom.us/j/96971889814
Meeting ID: 969 7188 9814 Passcode: 663036
Chair: Dr. Kelly Arnold

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Lecture / Discussion Mon, 29 Nov 2021 09:50:43 -0500 2021-12-08T13:00:00-05:00 2021-12-08T14:00:00-05:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Event
"EPICode, a multiplexed epitope barcoding strategy that enables dynamic cellular phenotypic screens" (December 9, 2021 4:00pm) https://events.umich.edu/event/89887 89887-21666282@events.umich.edu Event Begins: Thursday, December 9, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Pooled genetic libraries have improved screening throughput for mapping genotypes to phenotypes. However, selectable phenotypes are limiting, restricting screening to outcomes with a low spatiotemporal resolution. Here, we integrated live-cell imaging with pooled library-based screening. To enable intracellular multiplexing, we developed a method, called EPICode (Epitope-Phenotype Immunofluorescence barCode), that uses a combination of short epitopes to facilitate optical screening. By using the subcellular localization of the barcode as an additional channel, our method exponentially increases multiplexing capacity. Thus, after using live-cell microscopy to characterize a phenotype of interest, subjected to sequential stimulatory/inhibitory manipulations, the genotype of each cell in the population can be identified. To demonstrate applicability, we developed a live-cell PKA kinase translocation reporter with improved sensitivity and specificity. The use of epitopes as fluorescent barcodes introduces a scalable strategy for high-throughput screening broadly applicable to protein engineering and drug discovery settings where image-based phenotyping is desired.
Details:
DATE: Thursday, December 9, 2021
TIME: 4:00-5:00 pm
ZOOM LINK: https://umich.zoom.us/j/97723483179

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Workshop / Seminar Wed, 08 Dec 2021 11:33:18 -0500 2021-12-09T16:00:00-05:00 2021-12-09T17:00:00-05:00 Off Campus Location Biomedical Engineering Workshop / Seminar BME Event
Rising Sophomore UROP Application Open (December 13, 2021 7:00am) https://events.umich.edu/event/89569 89569-21664134@events.umich.edu Event Begins: Monday, December 13, 2021 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

The Undergraduate Research Opportunity Program is accepting applications from U-M rising sophomores for the 2022-2023 academic year cohort.

Participate in year-long research with mentors from across campus.

Applications open December 13, 2021
Priority Deadline March 7, 2022

Information Sessions will be offered in 2022:
- Wednesday, January 12, 2022 (12:00-1:00 p.m. ET)
- Tuesday, January 25, 2022 (5:00-6:00 p.m. ET)
- Monday, February 7, 2022 (12:00-1:00 p.m. ET)
- Thursday, February 24, 2022 (5:00-6:00 p.m. ET)
Info Session Registration: https://myumi.ch/qA17D

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Careers / Jobs Thu, 16 Dec 2021 15:39:23 -0500 2021-12-13T07:00:00-05:00 2021-12-13T23:59:00-05:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Rising Sophomore Application Open
RNA Faculty Candidate Seminar (December 13, 2021 4:00pm) https://events.umich.edu/event/89524 89524-21663803@events.umich.edu Event Begins: Monday, December 13, 2021 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

In-person/Hybrid seminar co-hosted by the Center for RNA Biomedicine and the Department of Molecular, Cellular, and Developmental Biology

Talk title: “Resolving the localisation and dynamics of mRNA and protein synthesis within neurons”

Keywords: mRNA dynamics, local protein synthesis, neurons, neuronal cell biology, synaptic plasticity, in vivo imaging

If you are having trouble registering, please contact Martina Jerant at mjerant@umich.edu

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Lecture / Discussion Tue, 30 Nov 2021 13:12:23 -0500 2021-12-13T16:00:00-05:00 2021-12-13T17:00:00-05:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion Paul Donlin-Asp, Ph.D.,
Rising Sophomore UROP Application Open (December 14, 2021 7:00am) https://events.umich.edu/event/89569 89569-21664135@events.umich.edu Event Begins: Tuesday, December 14, 2021 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

The Undergraduate Research Opportunity Program is accepting applications from U-M rising sophomores for the 2022-2023 academic year cohort.

Participate in year-long research with mentors from across campus.

Applications open December 13, 2021
Priority Deadline March 7, 2022

Information Sessions will be offered in 2022:
- Wednesday, January 12, 2022 (12:00-1:00 p.m. ET)
- Tuesday, January 25, 2022 (5:00-6:00 p.m. ET)
- Monday, February 7, 2022 (12:00-1:00 p.m. ET)
- Thursday, February 24, 2022 (5:00-6:00 p.m. ET)
Info Session Registration: https://myumi.ch/qA17D

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Careers / Jobs Thu, 16 Dec 2021 15:39:23 -0500 2021-12-14T07:00:00-05:00 2021-12-14T23:59:00-05:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Rising Sophomore Application Open
Rising Sophomore UROP Application Open (December 15, 2021 7:00am) https://events.umich.edu/event/89569 89569-21664136@events.umich.edu Event Begins: Wednesday, December 15, 2021 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

The Undergraduate Research Opportunity Program is accepting applications from U-M rising sophomores for the 2022-2023 academic year cohort.

Participate in year-long research with mentors from across campus.

Applications open December 13, 2021
Priority Deadline March 7, 2022

Information Sessions will be offered in 2022:
- Wednesday, January 12, 2022 (12:00-1:00 p.m. ET)
- Tuesday, January 25, 2022 (5:00-6:00 p.m. ET)
- Monday, February 7, 2022 (12:00-1:00 p.m. ET)
- Thursday, February 24, 2022 (5:00-6:00 p.m. ET)
Info Session Registration: https://myumi.ch/qA17D

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Careers / Jobs Thu, 16 Dec 2021 15:39:23 -0500 2021-12-15T07:00:00-05:00 2021-12-15T23:59:00-05:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Rising Sophomore Application Open
Rising Sophomore UROP Application Open (December 16, 2021 7:00am) https://events.umich.edu/event/89569 89569-21664137@events.umich.edu Event Begins: Thursday, December 16, 2021 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

The Undergraduate Research Opportunity Program is accepting applications from U-M rising sophomores for the 2022-2023 academic year cohort.

Participate in year-long research with mentors from across campus.

Applications open December 13, 2021
Priority Deadline March 7, 2022

Information Sessions will be offered in 2022:
- Wednesday, January 12, 2022 (12:00-1:00 p.m. ET)
- Tuesday, January 25, 2022 (5:00-6:00 p.m. ET)
- Monday, February 7, 2022 (12:00-1:00 p.m. ET)
- Thursday, February 24, 2022 (5:00-6:00 p.m. ET)
Info Session Registration: https://myumi.ch/qA17D

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Careers / Jobs Thu, 16 Dec 2021 15:39:23 -0500 2021-12-16T07:00:00-05:00 2021-12-16T23:59:00-05:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Rising Sophomore Application Open
Rising Sophomore UROP Application Open (December 17, 2021 7:00am) https://events.umich.edu/event/89569 89569-21664138@events.umich.edu Event Begins: Friday, December 17, 2021 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

The Undergraduate Research Opportunity Program is accepting applications from U-M rising sophomores for the 2022-2023 academic year cohort.

Participate in year-long research with mentors from across campus.

Applications open December 13, 2021
Priority Deadline March 7, 2022

Information Sessions will be offered in 2022:
- Wednesday, January 12, 2022 (12:00-1:00 p.m. ET)
- Tuesday, January 25, 2022 (5:00-6:00 p.m. ET)
- Monday, February 7, 2022 (12:00-1:00 p.m. ET)
- Thursday, February 24, 2022 (5:00-6:00 p.m. ET)
Info Session Registration: https://myumi.ch/qA17D

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Careers / Jobs Thu, 16 Dec 2021 15:39:23 -0500 2021-12-17T07:00:00-05:00 2021-12-17T23:59:00-05:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Rising Sophomore Application Open
U-M Structure Seminar: "The Structural and Functional Diversity of Microbial Encapsulin Nanocompartments" (December 17, 2021 10:00am) https://events.umich.edu/event/86442 86442-21634317@events.umich.edu Event Begins: Friday, December 17, 2021 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

Michael Andreas, Ph.D.
Postdoctoral Research Fellow
University of Michigan, Giessen Lab

Hybrid: LSI Library and Zoom - https://umich.zoom.us/j/97763780708 (Password: structure)

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Workshop / Seminar Wed, 01 Dec 2021 11:14:17 -0500 2021-12-17T10:00:00-05:00 2021-12-17T11:00:00-05:00 Life Sciences Institute U-M Structural Biology Workshop / Seminar U-M Structure
Rising Sophomore UROP Application Open (December 18, 2021 7:00am) https://events.umich.edu/event/89569 89569-21664139@events.umich.edu Event Begins: Saturday, December 18, 2021 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

The Undergraduate Research Opportunity Program is accepting applications from U-M rising sophomores for the 2022-2023 academic year cohort.

Participate in year-long research with mentors from across campus.

Applications open December 13, 2021
Priority Deadline March 7, 2022

Information Sessions will be offered in 2022:
- Wednesday, January 12, 2022 (12:00-1:00 p.m. ET)
- Tuesday, January 25, 2022 (5:00-6:00 p.m. ET)
- Monday, February 7, 2022 (12:00-1:00 p.m. ET)
- Thursday, February 24, 2022 (5:00-6:00 p.m. ET)
Info Session Registration: https://myumi.ch/qA17D

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Careers / Jobs Thu, 16 Dec 2021 15:39:23 -0500 2021-12-18T07:00:00-05:00 2021-12-18T23:59:00-05:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Rising Sophomore Application Open
Rising Sophomore UROP Application Open (December 19, 2021 7:00am) https://events.umich.edu/event/89569 89569-21664140@events.umich.edu Event Begins: Sunday, December 19, 2021 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

The Undergraduate Research Opportunity Program is accepting applications from U-M rising sophomores for the 2022-2023 academic year cohort.

Participate in year-long research with mentors from across campus.

Applications open December 13, 2021
Priority Deadline March 7, 2022

Information Sessions will be offered in 2022:
- Wednesday, January 12, 2022 (12:00-1:00 p.m. ET)
- Tuesday, January 25, 2022 (5:00-6:00 p.m. ET)
- Monday, February 7, 2022 (12:00-1:00 p.m. ET)
- Thursday, February 24, 2022 (5:00-6:00 p.m. ET)
Info Session Registration: https://myumi.ch/qA17D

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Careers / Jobs Thu, 16 Dec 2021 15:39:23 -0500 2021-12-19T07:00:00-05:00 2021-12-19T23:59:00-05:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Rising Sophomore Application Open
Rising Sophomore UROP Application Open (December 20, 2021 7:00am) https://events.umich.edu/event/89569 89569-21664141@events.umich.edu Event Begins: Monday, December 20, 2021 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

The Undergraduate Research Opportunity Program is accepting applications from U-M rising sophomores for the 2022-2023 academic year cohort.

Participate in year-long research with mentors from across campus.

Applications open December 13, 2021
Priority Deadline March 7, 2022

Information Sessions will be offered in 2022:
- Wednesday, January 12, 2022 (12:00-1:00 p.m. ET)
- Tuesday, January 25, 2022 (5:00-6:00 p.m. ET)
- Monday, February 7, 2022 (12:00-1:00 p.m. ET)
- Thursday, February 24, 2022 (5:00-6:00 p.m. ET)
Info Session Registration: https://myumi.ch/qA17D

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Careers / Jobs Thu, 16 Dec 2021 15:39:23 -0500 2021-12-20T07:00:00-05:00 2021-12-20T23:59:00-05:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Rising Sophomore Application Open
Rising Sophomore UROP Application Open (December 21, 2021 7:00am) https://events.umich.edu/event/89569 89569-21664142@events.umich.edu Event Begins: Tuesday, December 21, 2021 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

The Undergraduate Research Opportunity Program is accepting applications from U-M rising sophomores for the 2022-2023 academic year cohort.

Participate in year-long research with mentors from across campus.

Applications open December 13, 2021
Priority Deadline March 7, 2022

Information Sessions will be offered in 2022:
- Wednesday, January 12, 2022 (12:00-1:00 p.m. ET)
- Tuesday, January 25, 2022 (5:00-6:00 p.m. ET)
- Monday, February 7, 2022 (12:00-1:00 p.m. ET)
- Thursday, February 24, 2022 (5:00-6:00 p.m. ET)
Info Session Registration: https://myumi.ch/qA17D

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Careers / Jobs Thu, 16 Dec 2021 15:39:23 -0500 2021-12-21T07:00:00-05:00 2021-12-21T23:59:00-05:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Rising Sophomore Application Open
Rising Sophomore UROP Application Open (December 22, 2021 7:00am) https://events.umich.edu/event/89569 89569-21664143@events.umich.edu Event Begins: Wednesday, December 22, 2021 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

The Undergraduate Research Opportunity Program is accepting applications from U-M rising sophomores for the 2022-2023 academic year cohort.

Participate in year-long research with mentors from across campus.

Applications open December 13, 2021
Priority Deadline March 7, 2022

Information Sessions will be offered in 2022:
- Wednesday, January 12, 2022 (12:00-1:00 p.m. ET)
- Tuesday, January 25, 2022 (5:00-6:00 p.m. ET)
- Monday, February 7, 2022 (12:00-1:00 p.m. ET)
- Thursday, February 24, 2022 (5:00-6:00 p.m. ET)
Info Session Registration: https://myumi.ch/qA17D

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Careers / Jobs Thu, 16 Dec 2021 15:39:23 -0500 2021-12-22T07:00:00-05:00 2021-12-22T23:59:00-05:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Rising Sophomore Application Open
Rising Sophomore UROP Application Open (December 23, 2021 7:00am) https://events.umich.edu/event/89569 89569-21664144@events.umich.edu Event Begins: Thursday, December 23, 2021 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

The Undergraduate Research Opportunity Program is accepting applications from U-M rising sophomores for the 2022-2023 academic year cohort.

Participate in year-long research with mentors from across campus.

Applications open December 13, 2021
Priority Deadline March 7, 2022

Information Sessions will be offered in 2022:
- Wednesday, January 12, 2022 (12:00-1:00 p.m. ET)
- Tuesday, January 25, 2022 (5:00-6:00 p.m. ET)
- Monday, February 7, 2022 (12:00-1:00 p.m. ET)
- Thursday, February 24, 2022 (5:00-6:00 p.m. ET)
Info Session Registration: https://myumi.ch/qA17D

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Careers / Jobs Thu, 16 Dec 2021 15:39:23 -0500 2021-12-23T07:00:00-05:00 2021-12-23T23:59:00-05:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Rising Sophomore Application Open
Rising Sophomore UROP Application Open (December 24, 2021 7:00am) https://events.umich.edu/event/89569 89569-21664145@events.umich.edu Event Begins: Friday, December 24, 2021 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

The Undergraduate Research Opportunity Program is accepting applications from U-M rising sophomores for the 2022-2023 academic year cohort.

Participate in year-long research with mentors from across campus.

Applications open December 13, 2021
Priority Deadline March 7, 2022

Information Sessions will be offered in 2022:
- Wednesday, January 12, 2022 (12:00-1:00 p.m. ET)
- Tuesday, January 25, 2022 (5:00-6:00 p.m. ET)
- Monday, February 7, 2022 (12:00-1:00 p.m. ET)
- Thursday, February 24, 2022 (5:00-6:00 p.m. ET)
Info Session Registration: https://myumi.ch/qA17D

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Careers / Jobs Thu, 16 Dec 2021 15:39:23 -0500 2021-12-24T07:00:00-05:00 2021-12-24T23:59:00-05:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Rising Sophomore Application Open
Rising Sophomore UROP Application Open (December 25, 2021 7:00am) https://events.umich.edu/event/89569 89569-21664146@events.umich.edu Event Begins: Saturday, December 25, 2021 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

The Undergraduate Research Opportunity Program is accepting applications from U-M rising sophomores for the 2022-2023 academic year cohort.

Participate in year-long research with mentors from across campus.

Applications open December 13, 2021
Priority Deadline March 7, 2022

Information Sessions will be offered in 2022:
- Wednesday, January 12, 2022 (12:00-1:00 p.m. ET)
- Tuesday, January 25, 2022 (5:00-6:00 p.m. ET)
- Monday, February 7, 2022 (12:00-1:00 p.m. ET)
- Thursday, February 24, 2022 (5:00-6:00 p.m. ET)
Info Session Registration: https://myumi.ch/qA17D

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Careers / Jobs Thu, 16 Dec 2021 15:39:23 -0500 2021-12-25T07:00:00-05:00 2021-12-25T23:59:00-05:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Rising Sophomore Application Open
Rising Sophomore UROP Application Open (December 26, 2021 7:00am) https://events.umich.edu/event/89569 89569-21664147@events.umich.edu Event Begins: Sunday, December 26, 2021 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

The Undergraduate Research Opportunity Program is accepting applications from U-M rising sophomores for the 2022-2023 academic year cohort.

Participate in year-long research with mentors from across campus.

Applications open December 13, 2021
Priority Deadline March 7, 2022

Information Sessions will be offered in 2022:
- Wednesday, January 12, 2022 (12:00-1:00 p.m. ET)
- Tuesday, January 25, 2022 (5:00-6:00 p.m. ET)
- Monday, February 7, 2022 (12:00-1:00 p.m. ET)
- Thursday, February 24, 2022 (5:00-6:00 p.m. ET)
Info Session Registration: https://myumi.ch/qA17D

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Careers / Jobs Thu, 16 Dec 2021 15:39:23 -0500 2021-12-26T07:00:00-05:00 2021-12-26T23:59:00-05:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Rising Sophomore Application Open
Rising Sophomore UROP Application Open (December 27, 2021 7:00am) https://events.umich.edu/event/89569 89569-21664148@events.umich.edu Event Begins: Monday, December 27, 2021 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

The Undergraduate Research Opportunity Program is accepting applications from U-M rising sophomores for the 2022-2023 academic year cohort.

Participate in year-long research with mentors from across campus.

Applications open December 13, 2021
Priority Deadline March 7, 2022

Information Sessions will be offered in 2022:
- Wednesday, January 12, 2022 (12:00-1:00 p.m. ET)
- Tuesday, January 25, 2022 (5:00-6:00 p.m. ET)
- Monday, February 7, 2022 (12:00-1:00 p.m. ET)
- Thursday, February 24, 2022 (5:00-6:00 p.m. ET)
Info Session Registration: https://myumi.ch/qA17D

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Careers / Jobs Thu, 16 Dec 2021 15:39:23 -0500 2021-12-27T07:00:00-05:00 2021-12-27T23:59:00-05:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Rising Sophomore Application Open
Rising Sophomore UROP Application Open (December 28, 2021 7:00am) https://events.umich.edu/event/89569 89569-21664149@events.umich.edu Event Begins: Tuesday, December 28, 2021 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

The Undergraduate Research Opportunity Program is accepting applications from U-M rising sophomores for the 2022-2023 academic year cohort.

Participate in year-long research with mentors from across campus.

Applications open December 13, 2021
Priority Deadline March 7, 2022

Information Sessions will be offered in 2022:
- Wednesday, January 12, 2022 (12:00-1:00 p.m. ET)
- Tuesday, January 25, 2022 (5:00-6:00 p.m. ET)
- Monday, February 7, 2022 (12:00-1:00 p.m. ET)
- Thursday, February 24, 2022 (5:00-6:00 p.m. ET)
Info Session Registration: https://myumi.ch/qA17D

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Careers / Jobs Thu, 16 Dec 2021 15:39:23 -0500 2021-12-28T07:00:00-05:00 2021-12-28T23:59:00-05:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Rising Sophomore Application Open
Rising Sophomore UROP Application Open (December 29, 2021 7:00am) https://events.umich.edu/event/89569 89569-21664150@events.umich.edu Event Begins: Wednesday, December 29, 2021 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

The Undergraduate Research Opportunity Program is accepting applications from U-M rising sophomores for the 2022-2023 academic year cohort.

Participate in year-long research with mentors from across campus.

Applications open December 13, 2021
Priority Deadline March 7, 2022

Information Sessions will be offered in 2022:
- Wednesday, January 12, 2022 (12:00-1:00 p.m. ET)
- Tuesday, January 25, 2022 (5:00-6:00 p.m. ET)
- Monday, February 7, 2022 (12:00-1:00 p.m. ET)
- Thursday, February 24, 2022 (5:00-6:00 p.m. ET)
Info Session Registration: https://myumi.ch/qA17D

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Careers / Jobs Thu, 16 Dec 2021 15:39:23 -0500 2021-12-29T07:00:00-05:00 2021-12-29T23:59:00-05:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Rising Sophomore Application Open
Rising Sophomore UROP Application Open (December 30, 2021 7:00am) https://events.umich.edu/event/89569 89569-21664151@events.umich.edu Event Begins: Thursday, December 30, 2021 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

The Undergraduate Research Opportunity Program is accepting applications from U-M rising sophomores for the 2022-2023 academic year cohort.

Participate in year-long research with mentors from across campus.

Applications open December 13, 2021
Priority Deadline March 7, 2022

Information Sessions will be offered in 2022:
- Wednesday, January 12, 2022 (12:00-1:00 p.m. ET)
- Tuesday, January 25, 2022 (5:00-6:00 p.m. ET)
- Monday, February 7, 2022 (12:00-1:00 p.m. ET)
- Thursday, February 24, 2022 (5:00-6:00 p.m. ET)
Info Session Registration: https://myumi.ch/qA17D

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Careers / Jobs Thu, 16 Dec 2021 15:39:23 -0500 2021-12-30T07:00:00-05:00 2021-12-30T23:59:00-05:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Rising Sophomore Application Open
Rising Sophomore UROP Application Open (December 31, 2021 7:00am) https://events.umich.edu/event/89569 89569-21664152@events.umich.edu Event Begins: Friday, December 31, 2021 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

The Undergraduate Research Opportunity Program is accepting applications from U-M rising sophomores for the 2022-2023 academic year cohort.

Participate in year-long research with mentors from across campus.

Applications open December 13, 2021
Priority Deadline March 7, 2022

Information Sessions will be offered in 2022:
- Wednesday, January 12, 2022 (12:00-1:00 p.m. ET)
- Tuesday, January 25, 2022 (5:00-6:00 p.m. ET)
- Monday, February 7, 2022 (12:00-1:00 p.m. ET)
- Thursday, February 24, 2022 (5:00-6:00 p.m. ET)
Info Session Registration: https://myumi.ch/qA17D

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Careers / Jobs Thu, 16 Dec 2021 15:39:23 -0500 2021-12-31T07:00:00-05:00 2021-12-31T23:59:00-05:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Rising Sophomore Application Open
Rising Sophomore UROP Application Open (January 1, 2022 7:00am) https://events.umich.edu/event/89569 89569-21664153@events.umich.edu Event Begins: Saturday, January 1, 2022 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

The Undergraduate Research Opportunity Program is accepting applications from U-M rising sophomores for the 2022-2023 academic year cohort.

Participate in year-long research with mentors from across campus.

Applications open December 13, 2021
Priority Deadline March 7, 2022

Information Sessions will be offered in 2022:
- Wednesday, January 12, 2022 (12:00-1:00 p.m. ET)
- Tuesday, January 25, 2022 (5:00-6:00 p.m. ET)
- Monday, February 7, 2022 (12:00-1:00 p.m. ET)
- Thursday, February 24, 2022 (5:00-6:00 p.m. ET)
Info Session Registration: https://myumi.ch/qA17D

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Careers / Jobs Thu, 16 Dec 2021 15:39:23 -0500 2022-01-01T07:00:00-05:00 2022-01-01T23:59:00-05:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Rising Sophomore Application Open
Rising Sophomore UROP Application Open (January 2, 2022 7:00am) https://events.umich.edu/event/89569 89569-21664154@events.umich.edu Event Begins: Sunday, January 2, 2022 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

The Undergraduate Research Opportunity Program is accepting applications from U-M rising sophomores for the 2022-2023 academic year cohort.

Participate in year-long research with mentors from across campus.

Applications open December 13, 2021
Priority Deadline March 7, 2022

Information Sessions will be offered in 2022:
- Wednesday, January 12, 2022 (12:00-1:00 p.m. ET)
- Tuesday, January 25, 2022 (5:00-6:00 p.m. ET)
- Monday, February 7, 2022 (12:00-1:00 p.m. ET)
- Thursday, February 24, 2022 (5:00-6:00 p.m. ET)
Info Session Registration: https://myumi.ch/qA17D

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Careers / Jobs Thu, 16 Dec 2021 15:39:23 -0500 2022-01-02T07:00:00-05:00 2022-01-02T23:59:00-05:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Rising Sophomore Application Open
Rising Sophomore UROP Application Open (January 3, 2022 7:00am) https://events.umich.edu/event/89569 89569-21664155@events.umich.edu Event Begins: Monday, January 3, 2022 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

The Undergraduate Research Opportunity Program is accepting applications from U-M rising sophomores for the 2022-2023 academic year cohort.

Participate in year-long research with mentors from across campus.

Applications open December 13, 2021
Priority Deadline March 7, 2022

Information Sessions will be offered in 2022:
- Wednesday, January 12, 2022 (12:00-1:00 p.m. ET)
- Tuesday, January 25, 2022 (5:00-6:00 p.m. ET)
- Monday, February 7, 2022 (12:00-1:00 p.m. ET)
- Thursday, February 24, 2022 (5:00-6:00 p.m. ET)
Info Session Registration: https://myumi.ch/qA17D

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Careers / Jobs Thu, 16 Dec 2021 15:39:23 -0500 2022-01-03T07:00:00-05:00 2022-01-03T23:59:00-05:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Rising Sophomore Application Open
Rising Sophomore UROP Application Open (January 4, 2022 7:00am) https://events.umich.edu/event/89569 89569-21664156@events.umich.edu Event Begins: Tuesday, January 4, 2022 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

The Undergraduate Research Opportunity Program is accepting applications from U-M rising sophomores for the 2022-2023 academic year cohort.

Participate in year-long research with mentors from across campus.

Applications open December 13, 2021
Priority Deadline March 7, 2022

Information Sessions will be offered in 2022:
- Wednesday, January 12, 2022 (12:00-1:00 p.m. ET)
- Tuesday, January 25, 2022 (5:00-6:00 p.m. ET)
- Monday, February 7, 2022 (12:00-1:00 p.m. ET)
- Thursday, February 24, 2022 (5:00-6:00 p.m. ET)
Info Session Registration: https://myumi.ch/qA17D

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Careers / Jobs Thu, 16 Dec 2021 15:39:23 -0500 2022-01-04T07:00:00-05:00 2022-01-04T23:59:00-05:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Rising Sophomore Application Open
Rising Sophomore UROP Application Open (January 5, 2022 7:00am) https://events.umich.edu/event/89569 89569-21664157@events.umich.edu Event Begins: Wednesday, January 5, 2022 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

The Undergraduate Research Opportunity Program is accepting applications from U-M rising sophomores for the 2022-2023 academic year cohort.

Participate in year-long research with mentors from across campus.

Applications open December 13, 2021
Priority Deadline March 7, 2022

Information Sessions will be offered in 2022:
- Wednesday, January 12, 2022 (12:00-1:00 p.m. ET)
- Tuesday, January 25, 2022 (5:00-6:00 p.m. ET)
- Monday, February 7, 2022 (12:00-1:00 p.m. ET)
- Thursday, February 24, 2022 (5:00-6:00 p.m. ET)
Info Session Registration: https://myumi.ch/qA17D

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Careers / Jobs Thu, 16 Dec 2021 15:39:23 -0500 2022-01-05T07:00:00-05:00 2022-01-05T23:59:00-05:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Rising Sophomore Application Open
Rising Sophomore UROP Application Open (January 6, 2022 7:00am) https://events.umich.edu/event/89569 89569-21664158@events.umich.edu Event Begins: Thursday, January 6, 2022 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

The Undergraduate Research Opportunity Program is accepting applications from U-M rising sophomores for the 2022-2023 academic year cohort.

Participate in year-long research with mentors from across campus.

Applications open December 13, 2021
Priority Deadline March 7, 2022

Information Sessions will be offered in 2022:
- Wednesday, January 12, 2022 (12:00-1:00 p.m. ET)
- Tuesday, January 25, 2022 (5:00-6:00 p.m. ET)
- Monday, February 7, 2022 (12:00-1:00 p.m. ET)
- Thursday, February 24, 2022 (5:00-6:00 p.m. ET)
Info Session Registration: https://myumi.ch/qA17D

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Careers / Jobs Thu, 16 Dec 2021 15:39:23 -0500 2022-01-06T07:00:00-05:00 2022-01-06T23:59:00-05:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Rising Sophomore Application Open
Rising Sophomore UROP Application Open (January 7, 2022 7:00am) https://events.umich.edu/event/89569 89569-21664159@events.umich.edu Event Begins: Friday, January 7, 2022 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

The Undergraduate Research Opportunity Program is accepting applications from U-M rising sophomores for the 2022-2023 academic year cohort.

Participate in year-long research with mentors from across campus.

Applications open December 13, 2021
Priority Deadline March 7, 2022

Information Sessions will be offered in 2022:
- Wednesday, January 12, 2022 (12:00-1:00 p.m. ET)
- Tuesday, January 25, 2022 (5:00-6:00 p.m. ET)
- Monday, February 7, 2022 (12:00-1:00 p.m. ET)
- Thursday, February 24, 2022 (5:00-6:00 p.m. ET)
Info Session Registration: https://myumi.ch/qA17D

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Careers / Jobs Thu, 16 Dec 2021 15:39:23 -0500 2022-01-07T07:00:00-05:00 2022-01-07T23:59:00-05:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Rising Sophomore Application Open
Rising Sophomore UROP Application Open (January 8, 2022 7:00am) https://events.umich.edu/event/89569 89569-21664160@events.umich.edu Event Begins: Saturday, January 8, 2022 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

The Undergraduate Research Opportunity Program is accepting applications from U-M rising sophomores for the 2022-2023 academic year cohort.

Participate in year-long research with mentors from across campus.

Applications open December 13, 2021
Priority Deadline March 7, 2022

Information Sessions will be offered in 2022:
- Wednesday, January 12, 2022 (12:00-1:00 p.m. ET)
- Tuesday, January 25, 2022 (5:00-6:00 p.m. ET)
- Monday, February 7, 2022 (12:00-1:00 p.m. ET)
- Thursday, February 24, 2022 (5:00-6:00 p.m. ET)
Info Session Registration: https://myumi.ch/qA17D

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Careers / Jobs Thu, 16 Dec 2021 15:39:23 -0500 2022-01-08T07:00:00-05:00 2022-01-08T23:59:00-05:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Rising Sophomore Application Open
Rising Sophomore UROP Application Open (January 9, 2022 7:00am) https://events.umich.edu/event/89569 89569-21664161@events.umich.edu Event Begins: Sunday, January 9, 2022 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

The Undergraduate Research Opportunity Program is accepting applications from U-M rising sophomores for the 2022-2023 academic year cohort.

Participate in year-long research with mentors from across campus.

Applications open December 13, 2021
Priority Deadline March 7, 2022

Information Sessions will be offered in 2022:
- Wednesday, January 12, 2022 (12:00-1:00 p.m. ET)
- Tuesday, January 25, 2022 (5:00-6:00 p.m. ET)
- Monday, February 7, 2022 (12:00-1:00 p.m. ET)
- Thursday, February 24, 2022 (5:00-6:00 p.m. ET)
Info Session Registration: https://myumi.ch/qA17D

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Careers / Jobs Thu, 16 Dec 2021 15:39:23 -0500 2022-01-09T07:00:00-05:00 2022-01-09T23:59:00-05:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Rising Sophomore Application Open
CANCELED: Coming home: The LSO Returns (January 9, 2022 4:00pm) https://events.umich.edu/event/89967 89967-21667077@events.umich.edu Event Begins: Sunday, January 9, 2022 4:00pm
Location: Hill Auditorium
Organized By: Life Sciences Orchestra

THIS EVENT HAS BEEN CANCELED OUT OF AN ABUNDANCE OF CAUTION. ANY FURTHER PLANS WILL BE POSTED ON THE LSO WEBSITE.

After a two-year hiatus from performing on the stage of U-M's legendary Hill Auditorium, the U-M Life Sciences Orchestra will once again fill the hall with music on Sunday, Jan. 9 beginning at 4 p.m., with a free concert that will follow COVID safety protocols for performers and audience members alike.

No tickets are needed but good-fitting masks and proof of vaccination or a recent negative PCR test will be required and no children under 3 will be admitted. Full details of our COVID-19 safety protocols are below.

The concert, conducted by music director Yeo Ryeong Ahn assisted by Leonard Bopp, will feature three melodic and uplifting works that will appeal to all:
Aaron Copland - Outdoor Overture
Florence Price - Piano Concerto in One Movement with special guest soloist Xiaoya Liu
Antonin Dvorak - Symphony No. 9 in E minor, "From the New World", Op. 95, B. 178

Any updates to the concert schedule due to weather or U-M/local pandemic protocols will be posted on this website and on the LSO Facebook page.

COVID-19 Protocols:
For the safety of our audience and performers, we will follow strict safety protocols. We will update these as necessary depending on U-M and local/state public health guidance and any updates will be posted on this Facebook event and our website.
1. All attendees and performers must complete the Responsiblue screening and show their results on a smartphone or printout on arrival. Those who are part of the U-M community should use the logged-in version, which also displays vaccination status; those who are not part of the U-M community should use this link: https://bit.ly/LSOguest. This MUST be completed for each member of the party including children.

2. All attendees and performers must wear a good-fitting mask over their nose and mouth at all times except when drinking water. (Brass and woodwind players are permitted to remove it when actively playing, as all performers have been vaccinated.)

3. No children under age 3 will be allowed.

4. All children and adults must show proof of vaccination (card, photo of card, approved app such as MyChart or Clear, or logged-in Responsiblue screen) OR show the results of a PCR test taken no longer that 72 hours before the concert time.

5. No refreshments will be sold or allowed, though water may be brought in.

6. Families with 3- and 4-year-old children (too young to be vaccinated), and any party that includes children/adults who are not yet fully vaccinated, are asked to sit apart from others, preferably in the mezzanine (lower balcony).

7. We encourage everyone eligible for a booster vaccination (which is anyone over age 16) to seek a booster dose before attending.

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Performance Mon, 03 Jan 2022 12:35:04 -0500 2022-01-09T16:00:00-05:00 2022-01-09T17:45:00-05:00 Hill Auditorium Life Sciences Orchestra Performance LSO Concert poster featuring composer Florence Price
Rising Sophomore UROP Application Open (January 10, 2022 7:00am) https://events.umich.edu/event/89569 89569-21664162@events.umich.edu Event Begins: Monday, January 10, 2022 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

The Undergraduate Research Opportunity Program is accepting applications from U-M rising sophomores for the 2022-2023 academic year cohort.

Participate in year-long research with mentors from across campus.

Applications open December 13, 2021
Priority Deadline March 7, 2022

Information Sessions will be offered in 2022:
- Wednesday, January 12, 2022 (12:00-1:00 p.m. ET)
- Tuesday, January 25, 2022 (5:00-6:00 p.m. ET)
- Monday, February 7, 2022 (12:00-1:00 p.m. ET)
- Thursday, February 24, 2022 (5:00-6:00 p.m. ET)
Info Session Registration: https://myumi.ch/qA17D

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Careers / Jobs Thu, 16 Dec 2021 15:39:23 -0500 2022-01-10T07:00:00-05:00 2022-01-10T23:59:00-05:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Rising Sophomore Application Open
RISE Virtual Talking Circle (January 10, 2022 12:00pm) https://events.umich.edu/event/90030 90030-21667626@events.umich.edu Event Begins: Monday, January 10, 2022 12:00pm
Location: Off Campus Location
Organized By: RISE (Research. Innovation. Scholarship. Education.)

Crowdsourcing your input on our preliminary ideas emerging from the Health Science Education Innovation Task Force

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Workshop / Seminar Wed, 15 Dec 2021 07:01:39 -0500 2022-01-10T12:00:00-05:00 2022-01-10T13:00:00-05:00 Off Campus Location RISE (Research. Innovation. Scholarship. Education.) Workshop / Seminar RISE Virtual Talking Circle
RNA Faculty Candidate Seminar (January 10, 2022 4:00pm) https://events.umich.edu/event/89605 89605-21664519@events.umich.edu Event Begins: Monday, January 10, 2022 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

In-person/Hybrid seminar co-hosted by the Center for RNA Biomedicine, the Department of Biological Chemistry and the Department of Human Genetics

Talk title: “Uncovering novel translational control elements within 5' UTRs”

Abstract: Translational control of gene expression plays an essential role during development, response to stress and a wide range of cellular processes. However, the key mRNA features that distinguish efficiently translated from poorly translated mRNAs remain largely unknown. This talk will describe the development of direct analysis of ribosome targeting (DART) and its use both in discovering novel regulatory elements within 5′ untranslated regions (5′ UTRs) as well as revealing unexpected behaviors from features that were previously thought to be well understood.

If you are having trouble registering, please contact Martina Jerant at mjerant@umich.edu

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Lecture / Discussion Fri, 17 Dec 2021 15:59:37 -0500 2022-01-10T16:00:00-05:00 2022-01-10T17:00:00-05:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion Rachel Niederer, Yale School of Medicine
Rising Sophomore UROP Application Open (January 11, 2022 7:00am) https://events.umich.edu/event/89569 89569-21664163@events.umich.edu Event Begins: Tuesday, January 11, 2022 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

The Undergraduate Research Opportunity Program is accepting applications from U-M rising sophomores for the 2022-2023 academic year cohort.

Participate in year-long research with mentors from across campus.

Applications open December 13, 2021
Priority Deadline March 7, 2022

Information Sessions will be offered in 2022:
- Wednesday, January 12, 2022 (12:00-1:00 p.m. ET)
- Tuesday, January 25, 2022 (5:00-6:00 p.m. ET)
- Monday, February 7, 2022 (12:00-1:00 p.m. ET)
- Thursday, February 24, 2022 (5:00-6:00 p.m. ET)
Info Session Registration: https://myumi.ch/qA17D

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Careers / Jobs Thu, 16 Dec 2021 15:39:23 -0500 2022-01-11T07:00:00-05:00 2022-01-11T23:59:00-05:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Rising Sophomore Application Open
Rising Sophomore UROP Application Open (January 12, 2022 7:00am) https://events.umich.edu/event/89569 89569-21664164@events.umich.edu Event Begins: Wednesday, January 12, 2022 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

The Undergraduate Research Opportunity Program is accepting applications from U-M rising sophomores for the 2022-2023 academic year cohort.

Participate in year-long research with mentors from across campus.

Applications open December 13, 2021
Priority Deadline March 7, 2022

Information Sessions will be offered in 2022:
- Wednesday, January 12, 2022 (12:00-1:00 p.m. ET)
- Tuesday, January 25, 2022 (5:00-6:00 p.m. ET)
- Monday, February 7, 2022 (12:00-1:00 p.m. ET)
- Thursday, February 24, 2022 (5:00-6:00 p.m. ET)
Info Session Registration: https://myumi.ch/qA17D

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Careers / Jobs Thu, 16 Dec 2021 15:39:23 -0500 2022-01-12T07:00:00-05:00 2022-01-12T23:59:00-05:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Rising Sophomore Application Open
Child Health Data in the CVFS (January 12, 2022 2:00pm) https://events.umich.edu/event/85340 85340-21626253@events.umich.edu Event Begins: Wednesday, January 12, 2022 2:00pm
Location: Off Campus Location
Organized By: Institute for Social Research

This webinar series on the Chitwan Valley Family Study (CVFS) is about global and comparative population research. Sessions include measuring mental health, Covid-19, linking data, genetics, & migrant data.

Webinar 8: Child Health Data in the CVFS
Wednesday, January 12, 2022
2-3pm EDT
Presenter: Emily Treleaven

This webinar will give an overview of previous data collections of child health measures, child health outcomes among the CVFS sample, and compare child health indicators in the CVFS sample to the broader population of Nepal using Demographic and Health Survey data. There will be a Q&A session after the presentation.

The webinar will be hosted using Zoom. Registration is required to attend the webinar. Support provided by NICHD (R25 HD101358).

Registration is required for this event: https://umich.zoom.us/meeting/register/tJMqd-uprzIvHtapbdIOc1dQtiZmplrODd9k

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Presentation Tue, 17 Aug 2021 14:42:30 -0400 2022-01-12T14:00:00-05:00 2022-01-12T15:00:00-05:00 Off Campus Location Institute for Social Research Presentation Nepal mountains
Rising Sophomore UROP Application Open (January 13, 2022 7:00am) https://events.umich.edu/event/89569 89569-21664165@events.umich.edu Event Begins: Thursday, January 13, 2022 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

The Undergraduate Research Opportunity Program is accepting applications from U-M rising sophomores for the 2022-2023 academic year cohort.

Participate in year-long research with mentors from across campus.

Applications open December 13, 2021
Priority Deadline March 7, 2022

Information Sessions will be offered in 2022:
- Wednesday, January 12, 2022 (12:00-1:00 p.m. ET)
- Tuesday, January 25, 2022 (5:00-6:00 p.m. ET)
- Monday, February 7, 2022 (12:00-1:00 p.m. ET)
- Thursday, February 24, 2022 (5:00-6:00 p.m. ET)
Info Session Registration: https://myumi.ch/qA17D

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Careers / Jobs Thu, 16 Dec 2021 15:39:23 -0500 2022-01-13T07:00:00-05:00 2022-01-13T23:59:00-05:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Rising Sophomore Application Open
Cryo-ET Pipeline for Imaging Small Proteins in Large Biological Structures (January 13, 2022 9:30am) https://events.umich.edu/event/90501 90501-21671200@events.umich.edu Event Begins: Thursday, January 13, 2022 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: U-M Structural Biology

Correlative Light, and Electron Microscopy (CLEM) Faculty Candidate Seminar

Shiwei Zhu, Ph.D.
Research Specialist- MacMicking Lab, HHMI-Immunology & Microbial Pathogenesis, Yale Systems Biology Institute, Yale University

Hosted by: Cell and Developmental Biology & The Life Sciences Institute

Hybrid Zoom Meeting link: https://umich.zoom.us/j/99429897480 for those that are unable to attend

The venue is accessible via elevator and ramp and if you require any accommodations to fully participate in this activity, please inform:
Lori Mirabitur - Phone: (734) 615-7509 - Email: longeway@umich.edu

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Lecture / Discussion Thu, 06 Jan 2022 12:23:25 -0500 2022-01-13T09:30:00-05:00 2022-01-13T10:30:00-05:00 Taubman Biomedical Science Research Building U-M Structural Biology Lecture / Discussion flier
Rising Sophomore UROP Application Open (January 14, 2022 7:00am) https://events.umich.edu/event/89569 89569-21664166@events.umich.edu Event Begins: Friday, January 14, 2022 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

The Undergraduate Research Opportunity Program is accepting applications from U-M rising sophomores for the 2022-2023 academic year cohort.

Participate in year-long research with mentors from across campus.

Applications open December 13, 2021
Priority Deadline March 7, 2022

Information Sessions will be offered in 2022:
- Wednesday, January 12, 2022 (12:00-1:00 p.m. ET)
- Tuesday, January 25, 2022 (5:00-6:00 p.m. ET)
- Monday, February 7, 2022 (12:00-1:00 p.m. ET)
- Thursday, February 24, 2022 (5:00-6:00 p.m. ET)
Info Session Registration: https://myumi.ch/qA17D

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Careers / Jobs Thu, 16 Dec 2021 15:39:23 -0500 2022-01-14T07:00:00-05:00 2022-01-14T23:59:00-05:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Rising Sophomore Application Open
Rising Sophomore UROP Application Open (January 15, 2022 7:00am) https://events.umich.edu/event/89569 89569-21664167@events.umich.edu Event Begins: Saturday, January 15, 2022 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

The Undergraduate Research Opportunity Program is accepting applications from U-M rising sophomores for the 2022-2023 academic year cohort.

Participate in year-long research with mentors from across campus.

Applications open December 13, 2021
Priority Deadline March 7, 2022

Information Sessions will be offered in 2022:
- Wednesday, January 12, 2022 (12:00-1:00 p.m. ET)
- Tuesday, January 25, 2022 (5:00-6:00 p.m. ET)
- Monday, February 7, 2022 (12:00-1:00 p.m. ET)
- Thursday, February 24, 2022 (5:00-6:00 p.m. ET)
Info Session Registration: https://myumi.ch/qA17D

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Careers / Jobs Thu, 16 Dec 2021 15:39:23 -0500 2022-01-15T07:00:00-05:00 2022-01-15T23:59:00-05:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Rising Sophomore Application Open
Rising Sophomore UROP Application Open (January 16, 2022 7:00am) https://events.umich.edu/event/89569 89569-21664168@events.umich.edu Event Begins: Sunday, January 16, 2022 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

The Undergraduate Research Opportunity Program is accepting applications from U-M rising sophomores for the 2022-2023 academic year cohort.

Participate in year-long research with mentors from across campus.

Applications open December 13, 2021
Priority Deadline March 7, 2022

Information Sessions will be offered in 2022:
- Wednesday, January 12, 2022 (12:00-1:00 p.m. ET)
- Tuesday, January 25, 2022 (5:00-6:00 p.m. ET)
- Monday, February 7, 2022 (12:00-1:00 p.m. ET)
- Thursday, February 24, 2022 (5:00-6:00 p.m. ET)
Info Session Registration: https://myumi.ch/qA17D

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Careers / Jobs Thu, 16 Dec 2021 15:39:23 -0500 2022-01-16T07:00:00-05:00 2022-01-16T23:59:00-05:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Careers / Jobs UROP Rising Sophomore Application Open