Happening @ Michigan https://events.umich.edu/list/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. RNA Innovation Seminar, Ruslan Afasizhev, Boston University Medical Campus (October 21, 2019 4:00pm) https://events.umich.edu/event/65138 65138-16539449@events.umich.edu Event Begins: Monday, October 21, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Ruslan Afasizhev, PhD, Professor, Molecular & Cell Biology, Boston University Medical Campus

Abstract: Parasitic protist Trypanosoma brucei causes African human and animal trypanosomiasis, a spectrum of diseases affecting the population and economy in sub-Saharan Africa. These digenetic hemoflagellates belong to Kinetoplastea, a taxonomic class distinguished by possession of a kinetoplast. This nucleoprotein body contains mitochondrial DNA of two kinds: ~25 maxicircles (each ~23kb) encoding ribosomal RNAs, two guide RNA (gRNAs), ribosomal proteins and subunits of respiratory complexes, and approximately 5000 of ~1kb minicircles bearing the majority of gRNA genes. Relaxed maxicircles and minicircles are interlinked and packed into a dense disc-shaped network by association with histone-like proteins. Both maxicircle and minicircle genomes are transcribed by a phage-like RNA polymerase from multiple promoters into 3′-extended precursors which undergo 3′-5′ exonucleolytic trimming. To function in mitochondrial translation, pre-mRNAs must further proceed through 3′ adenylation, and often gRNA-directed uridine insertion/deletion editing, and 3′ A/U-tailing. Ribosomal and guide RNAs are typically 3′ uridylated. Historically, the fascinating phenomenon of RNA editing has attracted major research efforts, but more recent developments provided insights into pre- and post-edited processing events and identified key players in transforming primary precursors into functional RNAs and regulating their turnover. I will present a forward-looking model that integrates known modalities of mitochondrial RNA metabolism.

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Lecture / Discussion Wed, 25 Sep 2019 10:59:39 -0400 2019-10-21T16:00:00-04:00 2019-10-21T17:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion flyer
BIONIC Lunch: Artificial Intelligence in Medicine (October 22, 2019 12:00pm) https://events.umich.edu/event/63777 63777-15873595@events.umich.edu Event Begins: Tuesday, October 22, 2019 12:00pm
Location: North Campus Research Complex Building 10
Organized By: The Bioethics Discussion Group

Join us for a lunchtime discussion as we assess the computational engines assessing us.

Please RSVP: https://forms.gle/5t6UjXWNA1VSW4fr9

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Lecture / Discussion Mon, 23 Sep 2019 14:00:08 -0400 2019-10-22T12:00:00-04:00 2019-10-22T13:30:00-04:00 North Campus Research Complex Building 10 The Bioethics Discussion Group Lecture / Discussion Artificial Intelligence in Medicine
Professional Autobiography (October 22, 2019 8:00pm) https://events.umich.edu/event/67465 67465-16857939@events.umich.edu Event Begins: Tuesday, October 22, 2019 8:00pm
Location: Couzens Hall
Organized By: HSSP

Have you ever wondered how health care professionals end up in their careers? Professional Autobiographies are excellent opportunities for students to hear directly from health care professionals in an informal setting. During these talks, students will learn about speakers' motivations for their career choices, how their interests and experiences influenced their career trajectories, and how they’ve worked to align their passion(s) with their work. These sessions provide an excellent opportunity to connect with professionals who may be able to provide valuable advice during your Michigan career.

All HSSP-sponsored Professional Autobiographies are open to the public.

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Lecture / Discussion Thu, 19 Sep 2019 14:06:17 -0400 2019-10-22T20:00:00-04:00 2019-10-22T21:00:00-04:00 Couzens Hall HSSP Lecture / Discussion Gabriel Johnson
Department of Computational Medicine & Bioinformatics Weekly Seminar Series (October 23, 2019 4:00pm) https://events.umich.edu/event/68168 68168-17020453@events.umich.edu Event Begins: Wednesday, October 23, 2019 4:00pm
Location:
Organized By: DCMB Seminar Series

Talk Title: "Chromatin accessibility signatures of immune system aging"

Abstract: Aging is linked to deficiencies in immune responses and increased systemic inflammation. To unravel regulatory programs behind these changes, we profiled peripheral blood mononuclear cells (PBMCs) from young and old individuals (n=77) using ATAC-seq and RNA-seq technologies and analyzed these data via systems immunology tools. First, we described an epigenomic signature of immune system aging, with simultaneous systematic chromatin closing at promoters and enhancers associated with T cell signaling. This signature was primarily borne by memory CD8+ T cells, which exhibited an aging-related loss in IL7R activity and IL7 responsiveness. More recently to uncover the impact of sex on immune system aging, we studied PBMCs from 194 healthy adults (100 women, 94 men) ranging from 22-93 years old using ATAC-seq, RNA-seq, and flow cytometry technologies. These data revealed a shared epigenomic signature of aging between sexes composed of declines in naïve T cell functions and increases in monocyte and cytotoxic cell functions. Despite similarities, these changes were greater in magnitude in men. Additionally, we uncovered male-specific decreases in expression/accessibility of B-cell associated loci. Trajectory analyses revealed that age-related epigenomic changes were more abrupt at two timepoints in the human lifespan. The first timepoint was similar between sexes in terms of timing (early forties) and magnitude. In contrast, the latter timepoint was earlier (~5 years) and more pronounced in men (mid-sixties versus late-sixties). Unexpectedly, differences between men and women PBMCs increased with aging, with men having higher monocyte and pro-inflammatory activity and lower B/T cell activity compared to women after 65 years of age. Our study uncovered which immune cell functions and molecules are differentially affected with age between sexes, including the differences in timing and magnitude of changes, which is an important step towards precision medicine in older adults.

3:45 pm - Light refreshments served
4:00 pm - Lecture

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Lecture / Discussion Tue, 08 Oct 2019 15:12:18 -0400 2019-10-23T16:00:00-04:00 2019-10-23T17:00:00-04:00 DCMB Seminar Series Lecture / Discussion
Science, Technology, and Public Policy Graduate Certificate Info Session (October 23, 2019 4:00pm) https://events.umich.edu/event/67933 67933-16969022@events.umich.edu Event Begins: Wednesday, October 23, 2019 4:00pm
Location: Weill Hall (Ford School)
Organized By: Science, Technology, and Public Policy (STPP) Program

Join us for an information session about the Science, Technology, and Public Policy (STPP) Graduate Certificate!

Wednesday, October 23rd, 4:00pm-5:00pm
5240 Weill Hall
There will be SNACKS!

Do you want to learn how science and technology policy is made? Are you interested in the social and ethical implications of developments like gene editing and autonomous vehicles? Are you concerned about the increased politicization of science and research funding?

In the STPP graduate certificate program, graduate students from across the University analyze the role of science and technology in the policymaking process, gain experience writing for policymakers, and explore the political and policy landscape of areas such as biotechnology, information technology, energy, and others. Graduates of the STPP certificate have gone on to a range of policy-engaged scientific roles in government, NGOs, and academia.

More information about the program is available at: http://stpp.fordschool.umich.edu/graduate-certificate/

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Presentation Wed, 02 Oct 2019 13:21:49 -0400 2019-10-23T16:00:00-04:00 2019-10-23T17:00:00-04:00 Weill Hall (Ford School) Science, Technology, and Public Policy (STPP) Program Presentation Information Session promotional slide
RNA Innovation Seminar, Luis Batista, Washington University in St. Louis (October 28, 2019 4:00pm) https://events.umich.edu/event/65140 65140-16539450@events.umich.edu Event Begins: Monday, October 28, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Luis Batista, PhD, Assistant Professor of Medicine and Developmental Biology, Washington University in St. Louis

Abstract: The overarching goal of the Batista lab is to understand the regulation and function of telomerase in tissue fitness, disease, and cancer. The Batista laboratory uses genome-wide methods to uncover alterations that drive cellular failure upon critical telomerase dysfunction, using the targeted differentiation of human pluripotent stem cells to tissues of clinical relevance as a primary model. We combine in vitro biochemical and mechanistic studies with our ability to generate and differentiate pluripotent cells towards different fates to better understand the importance of correct ribonucleoprotein assembly and function in tissue fitness and to determine the events that lead from impaired RNA-protein assembly to disease in humans.

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Lecture / Discussion Wed, 25 Sep 2019 11:00:45 -0400 2019-10-28T16:00:00-04:00 2019-10-28T17:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion flyer
IOE 813 Seminar: Katie Esper, MPH, MHCDS (October 28, 2019 4:30pm) https://events.umich.edu/event/68702 68702-17138822@events.umich.edu Event Begins: Monday, October 28, 2019 4:30pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: U-M Industrial & Operations Engineering

Katie joined the Johns Hopkins University Applied Physics Laboratory (JHU/APL) in 2010 as a health systems engineer after a few years with a healthcare software company. She has worked directly with the military health system implementing multi-site healthcare delivery initiatives and data driven management systems. Katie’s interests are in population need assessments, practice variation studies, and system design for enterprise wide application. Katie is currently the Program Manager of Force Health and Readiness, overseeing the mission of ensuring a ready medical force, a medically ready force, and the delivery of safe reliable care across all operational settings. In this position, Katie is a strategic thought partner for military leaders and oversees a Warfighter Readiness Performance Improvement portfolio of work.

Katie holds a Bachelor’s degree in Industrial and Operations Engineering from the University of Michigan, a Master’s of Public Health from Johns Hopkins Bloomberg School of Public Health (with a focus in Quality, Patient Safety, and Outcomes Research), and a Master’s in Healthcare Delivery Science from Dartmouth College.

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Lecture / Discussion Tue, 22 Oct 2019 15:03:56 -0400 2019-10-28T16:30:00-04:00 2019-10-28T18:00:00-04:00 Lurie Biomedical Engineering (formerly ATL) U-M Industrial & Operations Engineering Lecture / Discussion Katie Esper
INFORMATION SESSION: HEALTHCARE DELIVERY IN EMERGING MARKETS (October 28, 2019 5:30pm) https://events.umich.edu/event/68480 68480-17088477@events.umich.edu Event Begins: Monday, October 28, 2019 5:30pm
Location: Ross School of Business
Organized By: William Davidson Institute

This course provides students with the unique opportunity to examine business models for healthcare delivery in emerging markets. Join us at this information session to learn about the winter 2020 projects and travel locations!

For more information, please email BA685-Healthcare@umich.edu

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Meeting Thu, 17 Oct 2019 10:25:29 -0400 2019-10-28T17:30:00-04:00 2019-10-28T18:30:00-04:00 Ross School of Business William Davidson Institute Meeting BA685 Students from the Kisii Eye Hospital Team in Kenya
Blood Battle Kick-off (October 29, 2019 12:00pm) https://events.umich.edu/event/68706 68706-17138826@events.umich.edu Event Begins: Tuesday, October 29, 2019 12:00pm
Location: Diag - Central Campus
Organized By: Wolverines for Life

Help us kick off the Blood Battle at Michigan and defeat OSU by making an appointment to donate blood.

In the spirit of competition, we'll have five Brutus the Buckeye pinatas ready to take a beating in front of Hatcher Library.

There's no cost to attend. Just bring some aggression and the urge to beat Brutus with a stick.

We'll also have some fun giveaways throughout the afternoon!

Schedule a blood drive appointment between 10/29/2019 and 11/27/2019 to help us beat OSU in the annual Blood Battle competition! Visit www.redcrossblood.org and enter promo code "goblue."

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Recreational / Games Tue, 22 Oct 2019 15:54:03 -0400 2019-10-29T12:00:00-04:00 2019-10-29T17:00:00-04:00 Diag - Central Campus Wolverines for Life Recreational / Games Brutus Beatdown
Restoring Movement via Electrodes Implanted in the Brain (October 29, 2019 1:30pm) https://events.umich.edu/event/64669 64669-16420901@events.umich.edu Event Begins: Tuesday, October 29, 2019 1:30pm
Location: Off Campus Location
Organized By: Osher Lifelong Learning Institute (50+)

The dream of using signals from the brain to restore motor control in people with paralysis or amputation is getting closer to reality. Electrodes that monitor or send signals to neurons in the brain have been reduced in size until they are no bigger than the neurons themselves, and arrays can interface with hundreds of individual neurons.
The course will discuss this area of research and highlight one such application, where 8-µm carbon electrodes implanted in the finger control areas of the brain are being developed to control movement of individual fingers. Cynthia Chestek, instructor, is an associate professor of biomedical engineering at the University of Michigan, where she runs the Cortical Neural Prosthetics Laboratory. This Study Group is for those 50 and over and meets Tuesday, 1:30–3:00 pm on October 29.

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Class / Instruction Sun, 28 Jul 2019 16:09:46 -0400 2019-10-29T13:30:00-04:00 2019-10-29T15:00:00-04:00 Off Campus Location Osher Lifelong Learning Institute (50+) Class / Instruction Study Group
MedChem Seminar (October 29, 2019 2:30pm) https://events.umich.edu/event/68813 68813-17155482@events.umich.edu Event Begins: Tuesday, October 29, 2019 2:30pm
Location: Pharmacy College
Organized By: Department of Medicinal Chemistry

Understanding—and Overcoming—Therapy Resistance in Breast and Prostate Cancers

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Lecture / Discussion Thu, 24 Oct 2019 12:58:51 -0400 2019-10-29T14:30:00-04:00 2019-10-29T15:30:00-04:00 Pharmacy College Department of Medicinal Chemistry Lecture / Discussion Pharmacy College
Bioethics Discussion: Fear (October 29, 2019 7:00pm) https://events.umich.edu/event/52720 52720-12974152@events.umich.edu Event Begins: Tuesday, October 29, 2019 7:00pm
Location: Lurie Biomedical Engineering
Organized By: The Bioethics Discussion Group

A discussion of our deepest darkest depths.

Readings to consider:
1. Fear
2. A Method for Evaluating the Ethics of Fear Appeals
3. Does fear of retaliation deter requests for ethics consultation?
4. The Two Faces of Fear: A History of Hard-Hitting Public Health Campaigns Against Tobacco and AIDS
5. Professor Nobody’s Little Lectures on Supernatural Horror

For more information and/or to receive a copy of the readings contact Barry Belmont at belmont@umich.edu or visit http://belmont.bme.umich.edu/bioethics-discussion-group/discussions/034-fear/.

Please also don't be afraid to check out the blog: https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Tue, 13 Aug 2019 10:52:38 -0400 2019-10-29T19:00:00-04:00 2019-10-29T20:30:00-04:00 Lurie Biomedical Engineering The Bioethics Discussion Group Lecture / Discussion Fear
Contemporary Issues Discussion: Dental Health (October 30, 2019 12:00pm) https://events.umich.edu/event/67874 67874-16960534@events.umich.edu Event Begins: Wednesday, October 30, 2019 12:00pm
Location: Tisch Hall
Organized By: William L. Clements Library

Teenage newlywed Phebe Jane Knapp wrote a letter to her brother in 1851 describing her dental pain as well as other health issues, while she and her husband Marquis settled in the new state of Iowa.

All are welcome to a discussion with historians, curators, dentists, and archivists to explore how this powerful letter relates to current issues within dental care. Join in the conversation by sharing your own history and personal reflections with other U-M and local community members over a complimentary lunch. Free, registration is required. Please register online (or call 734-647-0864 to register) by Oct. 28.

Sponsored by Frank and Judy Wilhelme. Presented by the U-M Clements Library, the U-M Sindecuse Museum of Dentistry, and the U-M Eisenberg Institute for Historical Studies.

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Lecture / Discussion Tue, 01 Oct 2019 14:57:24 -0400 2019-10-30T12:00:00-04:00 2019-10-30T13:00:00-04:00 Tisch Hall William L. Clements Library Lecture / Discussion The anatomy, physiology, and diseases of the teeth. By Thomas Bell ... (1831)
13th Annual Susan B. Meister Lecture in Child Health Policy (October 30, 2019 4:00pm) https://events.umich.edu/event/67523 67523-16890090@events.umich.edu Event Begins: Wednesday, October 30, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Child Health Evaluation And Research Center (CHEAR)

Registration is now open for the 13th annual Susan B. Meister Lecture in Child Health Policy sponsored by the Susan B. Meister Child Health Evaluation and Research (CHEAR) Center.

This year, CHEAR welcomes Robert Gordon, JD, the director of the Michigan Department of Health and Human Services. Director Gordon will speak on the topic of food insecurity and child health.

An open reception and poster session will follow the lecture from 5:30-6:30pm.
This lecture is free and open to all members of the University of Michigan community and the general public, but registration is required.

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Lecture / Discussion Mon, 23 Sep 2019 09:39:16 -0400 2019-10-30T16:00:00-04:00 2019-10-30T18:30:00-04:00 Taubman Biomedical Science Research Building Child Health Evaluation And Research Center (CHEAR) Lecture / Discussion 13th Annual Susan B. Meister Lecture in Child Health Policy
Evaluating the Effectiveness of Team and Leadership Training Interventions in Emergency Medical Teams (November 1, 2019 1:30pm) https://events.umich.edu/event/67886 67886-16960561@events.umich.edu Event Begins: Friday, November 1, 2019 1:30pm
Location: Ross School of Business
Organized By: Interdisciplinary Committee on Organizational Studies - ICOS

Teamwork failures have been directly linked with medical errors and adverse patient events. As a result, multiple efforts have been made to improve the leadership and performance of healthcare teams. Two studies will be presented that assess team training effects on teamwork behaviors and patient outcomes for emergency medical teams. In the first study, a computer-based team training program was designed to familiarize emergency medical residents on eight teamwork processes. Results showed teams that received this training were significantly better than placebo training teams on both teamwork and patient care outcomes in high-fidelity simulated patient resuscitation scenarios. In the second study, a simulated-based team leadership training program was designed to train trauma team leaders on behaviors important to action team leadership. In a randomized controlled trial, trauma team leaders were video recorded in actual trauma resuscitations, before and after training. Results showed a significant difference in post-training leadership behaviors between the training and control conditions. Furthermore, leadership behaviors were found to mediate an effect of training on patient care with a significant indirect effect.

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Lecture / Discussion Tue, 01 Oct 2019 16:58:48 -0400 2019-11-01T13:30:00-04:00 2019-11-01T15:00:00-04:00 Ross School of Business Interdisciplinary Committee on Organizational Studies - ICOS Lecture / Discussion Ross School of Business
The Annual Bernard W. Agranoff Lectureship in Neuroscience (November 4, 2019 3:15pm) https://events.umich.edu/event/68666 68666-17136728@events.umich.edu Event Begins: Monday, November 4, 2019 3:15pm
Location: University Hospitals
Organized By: Michigan Neuroscience Institute

This annual lectureship features a pre-eminent neuroscientist and honors Bernard W. Agranoff, a leader in biochemistry and an internationally recognized expert in the neurosciences. Dr. Agranoff is a graduate of the University of Michigan who returned as a faculty member in 1960. He served as the Director of Mental Health Research Institute (now known as the Molecular and Behavioral Neuroscience Institute) from 1985 to 1995 and was the Neuroscience Laboratory Building Director from 1983-2002. His scientific career helped establish that long-term memory formation requires de novo protein synthesis and also enhanced our understanding of the processes involved in nerve regeneration. The Lectureship builds upon a career dedicated to promoting excellence in research, education, and mental health care and is an enduring legacy to those seeking to improve our understanding of the brain and apply that knowledge to help those with brain disorders.

Dr. Richard Huganir is the 2019 Agranoff Lecturer. Dr. Huganir is a Bloomberg Distinguished Professor of Neuroscience and Psychological and Brain Sciences and Director of the Solomon H. Snyder Department of Neuroscience at the Johns Hopkins School of Medicine. His career has focused on synapses in the brain. His research has shown that the regulation of receptor function is a major mechanism for the regulation of neuronal excitability and connectivity in the brain and is critical for many higher brain processes, including learning and memory, and is a major determinant of behavior. Moreover, dysregulation of these mechanisms underlies many neurological and psychiatric diseases including Alzheimer’s, ALS, schizophrenia, autism, intellectual disability, PTSD as well as in chronic pain and drug addiction. Dr. Huganir is a member of the American Academy of Arts and Sciences, the National Institute of Medicine and the National Academy of Sciences.

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Lecture / Discussion Tue, 22 Oct 2019 10:00:19 -0400 2019-11-04T15:15:00-05:00 2019-11-04T16:30:00-05:00 University Hospitals Michigan Neuroscience Institute Lecture / Discussion Dr. Richard Huganir
The Molecular and Integrative Physiology Seminar Series is proud to present and welcome all to attend: (November 4, 2019 4:00pm) https://events.umich.edu/event/69102 69102-17244692@events.umich.edu Event Begins: Monday, November 4, 2019 4:00pm
Location: Medical Science Unit II
Organized By: Biosciences Initiative

"Designing chemogenetic and optogenetic tools for mapping and modulating GPCR signaling."

Light refreshments will be served at 3:45pm

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Workshop / Seminar Mon, 04 Nov 2019 14:41:57 -0500 2019-11-04T16:00:00-05:00 2019-11-04T17:00:00-05:00 Medical Science Unit II Biosciences Initiative Workshop / Seminar
IOE 813 Seminar: Michael Krautmann, MSE (November 4, 2019 4:30pm) https://events.umich.edu/event/68998 68998-17211731@events.umich.edu Event Begins: Monday, November 4, 2019 4:30pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: U-M Industrial & Operations Engineering

Proven medicines and technologies already exist to address many of the world's biggest health challenges. But these products are only effective when they can be reliably delivered to the patients who need them, and in many low- and middle-income countries (LMICs), health product supply chains are not as efficient or reliable as they need to be. Patients and providers often lack access to quality, affordable medicines, and health outcomes suffer as a result.
 
Governments, businesses, multilateral agencies, and nonprofits are all play a critical role in LMIC health supply chains, but each have their own unique perspectives, processes, and goals. Improving supply chain performance in this context requires a systems thinking approach, one that combines traditional logistics management and optimization techniques with a more holistic understanding of how to incentivize and align the actions of diverse organizations.
 
In this session we will explore the William Davidson Institute's work in improving LMIC health supply chain performance, and will highlight lessons and experiences that are applicable in any complex health system environment.

Michael Krautmann joined the William Davidson Institute's Healthcare Initiative in 2015. His research and consulting work focuses on modeling, investment decisionmaking, and strategy development to improve the operational efficiency and service levels of public health supply chains. While at WDI Michael has helped develop several Excel tools and white papers that inform key elements of the supply chain design and strategy development process. He has also conducted strategic evaluations of ongoing supply chain programs in several countries, helping client organizations improve their approach for providing technical assistance and delivering health products.
 
Michael holds master’s and bachelor’s degrees in Industrial and Operations Engineering from the University of Michigan.  Prior to joining WDI, he worked for Lean Care Solutions, a healthcare technology startup that uses predictive analytics to help hospitals improve patient scheduling and postoperative care. He also served as a Peace Corps Volunteer in Zambia, where he helped evaluate clinic-level supply chain practices for a United States Agency for International Development-funded health project.

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Lecture / Discussion Thu, 31 Oct 2019 09:26:56 -0400 2019-11-04T16:30:00-05:00 2019-11-04T18:00:00-05:00 Lurie Biomedical Engineering (formerly ATL) U-M Industrial & Operations Engineering Lecture / Discussion Michael Krautmann, MSE
Neuroscience/Pre-Health Walk-In Co-Advising Session (November 6, 2019 11:00am) https://events.umich.edu/event/69093 69093-17244686@events.umich.edu Event Begins: Wednesday, November 6, 2019 11:00am
Location: Undergraduate Science Building
Organized By: Program in Biology

Come have your questions about neuroscience or pre-health studies answered during our Walk-In Co-Advising Session! Advisors will be ready to answer your questions!

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Careers / Jobs Mon, 04 Nov 2019 12:32:28 -0500 2019-11-06T11:00:00-05:00 2019-11-06T13:00:00-05:00 Undergraduate Science Building Program in Biology Careers / Jobs
Department of Computational Medicine & Bioinformatics Weekly Seminar (November 6, 2019 4:00pm) https://events.umich.edu/event/68926 68926-17197024@events.umich.edu Event Begins: Wednesday, November 6, 2019 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract: Although central architectures drive robust oscillations, biological clock networks containing the same core vary drastically in their potential to oscillate. What peripheral structures contribute to the variation of oscillation behaviors remains elusive. We computationally generated an atlas of oscillators and found that, while certain core topologies are essential for robust oscillations, local structures substantially modulate the degree of robustness. Strikingly, two key local structures, incoherent inputs and coherent inputs, can modify a core topology to promote and attenuate its robustness, additively. These findings underscore the importance of local modifications besides robust cores, which explain why auxiliary structures not required for oscillation are evolutionarily conserved. We further apply this computational framework to search for structures underlying tunability, another crucial property shared by many biological timing systems to adapt their frequencies to environmental changes.

Experimentally, we developed an artificial cell system to reconstitute mitotic oscillatory processes in water-in-oil microemulsions. With a multi-inlet pressure-driven microfluidic setup, these artificial cells are flexibly adjustable in sizes, periods, various molecular and drug concentrations, energy, and subcellular compartments. Using long-term time-lapse fluorescence microscopy, this system enables high-throughput, single-cell analysis of clock dynamics, functions, and stochasticity, key to elucidating the topology-function relation of biological clocks.

We also investigate how multiple clocks coordinate via biochemical and mechanical signals in the essential developmental processes of early zebrafish embryos (e.g., mitotic wave propagation, synchronous embryo cleavages, and somitogenesis). To pin down the physical mechanisms that give rise to these complex collective phenomena, we integrate mathematical modeling, live embryo and explant imaging, nanofabrication, micro-contact printing, and systems and synthetic biology approaches.

BlueJeans livestream: https://primetime.bluejeans.com/a2m/live-event/rbuvycdc
Qiong Yang: https://medicine.umich.edu/dept/dcmb/qiong-yang-phd

3:45 pm to 4:00 pm - Light refreshments
4:00 pm - Lecture

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Lecture / Discussion Tue, 29 Oct 2019 12:56:42 -0400 2019-11-06T16:00:00-05:00 2019-11-06T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
In Conversation: Copying and Creativity in Human and Machine Learning (November 10, 2019 3:00pm) https://events.umich.edu/event/65026 65026-16503317@events.umich.edu Event Begins: Sunday, November 10, 2019 3:00pm
Location: Museum of Art
Organized By: University of Michigan Museum of Art (UMMA)

Through works of art spanning ancient to contemporary times, UMMA's exhibition Copies and Invention in East Asia challenges our understanding of originality, and presents copying as an act of imaginative interpretation. But what is the connection between copying and invention? How does the practice of copying an artist’s work increase a drawing student’s own creativity? How do computers look at works of art to learn how to emulate a particular artist’s style? Consider these questions along with Raj Rao Nadakuditi, Associate Professor of Electrical Engineering and Computers and expert in machine learning and signal processing; Jeff Evans, Clinical Associate Professor Emeritus of Physical Medicine and Rehabilitation at the Medical School, Lecturer in the Residential College, and scholar of the psychology of creativity; and Natsu Oyobe, UMMA Curator of Asian Art.

Lead support is provided by the University of Michigan Office of the Provost, Michigan Medicine, Lieberthal-Rogel Center for Chinese Studies, Center for Japanese Studies, Nam Center for Korean Studies, School of Information, and College of Engineering. Additional generous support is provided by the University of Michigan Fabrication Studio at the Duderstadt Center, Department of Asian Languages and Cultures, and SeeMeCNC 3D Printers.

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Lecture / Discussion Sat, 09 Nov 2019 18:16:53 -0500 2019-11-10T15:00:00-05:00 2019-11-10T15:45:00-05:00 Museum of Art University of Michigan Museum of Art (UMMA) Lecture / Discussion Museum of Art
In Conversation: Copying and Creativity in Human and Machine Learning (November 10, 2019 4:00pm) https://events.umich.edu/event/65733 65733-16631992@events.umich.edu Event Begins: Sunday, November 10, 2019 4:00pm
Location: Museum of Art
Organized By: University of Michigan Museum of Art (UMMA)

Through works of art spanning ancient to contemporary times, UMMA's exhibition Copies and Invention in East Asia challenges our understanding of originality, and presents copying as an act of imaginative interpretation. But what is the connection between copying and invention? How does the practice of copying an artist’s work increase a drawing student’s own creativity? How do computers look at works of art to learn how to emulate a particular artist’s style? Consider these questions along with Raj Rao Nadakuditi, Associate Professor of Electrical Engineering and Computers and expert in machine learning and signal processing; Jeff Evans, Clinical Associate Professor Emeritus of Physical Medicine and Rehabilitation at the Medical School, Lecturer in the Residential College, and scholar of the psychology of creativity; and Natsu Oyobe, UMMA Curator of Asian Art.

Lead support is provided by the University of Michigan Office of the Provost, Michigan Medicine, Lieberthal-Rogel Center for Chinese Studies, Center for Japanese Studies, Nam Center for Korean Studies, School of Information, and College of Engineering. Additional generous support is provided by the University of Michigan Fabrication Studio at the Duderstadt Center, Department of Asian Languages and Cultures, and SeeMeCNC 3D Printers.

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Lecture / Discussion Fri, 25 Oct 2019 18:18:08 -0400 2019-11-10T16:00:00-05:00 2019-11-10T16:45:00-05:00 Museum of Art University of Michigan Museum of Art (UMMA) Lecture / Discussion Museum of Art
"Cure: A Journey into the Science of Mind Over Matter" (November 11, 2019 10:00am) https://events.umich.edu/event/64658 64658-16410956@events.umich.edu Event Begins: Monday, November 11, 2019 10:00am
Location: Off Campus Location
Organized By: Osher Lifelong Learning Institute (50+)

Serious scientists from a range of fields have been uncovering evidence that our thoughts, emotions, and beliefs can ease pain, heal wounds, fend off infection and heart disease, and even slow the progression of AIDS and some cancers. Author of the title book, Jo Marchant, explores the vast potential of the mind’s ability to heal, lays out its limitations, and explains how we can make use of these findings in our own lives.
Amazon Review: “With clarity and compassion, Marchant points the way towards a system of medicine that treats us not simply as bodies but as human beings.” So, let’s bring our open minds and our healthy skepticism to examine this fascinating look into the possible future of medicine. Mike Murray, instructor, is a Clinical Psychologist. This Study Group is for those 50 and over and meets Mondays, 10:00 am-12:00 pm on November 11 - December 16.

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Class / Instruction Sat, 27 Jul 2019 09:43:19 -0400 2019-11-11T10:00:00-05:00 2019-11-11T12:00:00-05:00 Off Campus Location Osher Lifelong Learning Institute (50+) Class / Instruction Study Group
Personalizing treatment in cardiovascular diseases (November 11, 2019 12:00pm) https://events.umich.edu/event/67329 67329-16839870@events.umich.edu Event Begins: Monday, November 11, 2019 12:00pm
Location: 1100 North University Building
Organized By: Precision Health

Listen to a presentation on personalized treatments in cardiovascular disease given by Simon de Denus, the Beaulieu-Saucier Chair in Pharmacogenomics at the Université de Montréal, whose research and teaching interests are in the areas of cardiovascular pharmacotherapy and personalized medicine.

He completed his Bachelor of Pharmacy at the Université de Montréal (UdeM) in 1999 and completed his MSc in hospital pharmacy practice at the Université de Montréal in 2000. He then completed a residency in cardiovascular pharmacotherapy at the Hôpital du Sacré-Coeur in Montreal and then a Fellowship at the University of the Sciences in Philadelphia. De Denus obtained his PhD in pharmaceutical sciences from UdeM. He is a Professor at the Faculty of Pharmacy of UdeM, as well as a pharmacist and researcher at the Montreal Heart Institute. He has published over 80 articles in journals such *Chest*, *Archives of Internal Medicine*, *Pharmacogenomics Journal*, *Circulation: Cardiovascular Genetics*, *American Heart Journal*, and the *New England Journal of Medicine*. He has also authored more than 15 book chapters.

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Presentation Tue, 17 Sep 2019 12:31:02 -0400 2019-11-11T12:00:00-05:00 2019-11-11T13:00:00-05:00 1100 North University Building Precision Health Presentation Simon de Denus
RNA Innovation Seminar, Bruce Sullenger, Duke School of Medicine (November 11, 2019 4:00pm) https://events.umich.edu/event/65141 65141-16539451@events.umich.edu Event Begins: Monday, November 11, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Bruce A. Sullenger, Ph.D.
Joseph and Dorothy Beard Professor
Department of Surgery
Professor of Pharmacology and Cancer Biology
Duke University Medical Center

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Lecture / Discussion Thu, 24 Oct 2019 08:30:39 -0400 2019-11-11T16:00:00-05:00 2019-11-11T17:00:00-05:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion flyer
IOE 813 Seminar: Lavanya Marla, PhD (November 11, 2019 4:30pm) https://events.umich.edu/event/69237 69237-17269241@events.umich.edu Event Begins: Monday, November 11, 2019 4:30pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: U-M Industrial & Operations Engineering

We present an efficient data-driven computational solution and bounding approach for static allocation of an ambulance fleet and its dynamic redeployment, where the goal is to position (or re-position) ambulances to bases to maximize the system's service level. Central to our approach is a discrete-event simulator to evaluate the impact of ambulance deployments to logs of emergency requests. We first model ambulance allocation as an approximately-submodular-maximization problem, and devise a simple and efficient greedy algorithm that produces both static allocations and dynamic repositioning policies. In parallel, we find data-driven information-relaxation bounds for both static and dynamic cases. We build even tighter information-relaxation bounds by penalizing the previous relaxations. Our approach allows the computation of tight bounds without incurring the curse of dimensionality common to such approaches. Our bounding methods help inform policymakers about the viability of proposed fleet sizes and policies being adopted by the contracted EMS agencies. Our computational experiments on an Asian city's EMS demonstrate the tractability and efficiency of our greedy algorithm and our bounding methods.

The first part of this work is with Ramayya Krishnan and Yisong Yue, and the latter part with Achal Bassamboo.

Lavanya Marla is an Assistant Professor in Industrial and Enterprise Systems Engineering at the University of Illinois at Urbana-Champaign. Prior to her current position, she was a Systems Scientist with the Heinz College at Carnegie Mellon University; and earned her PhD in Transportation Systems from MIT and Bachelors degree from IIT Madras. Her research interests are in robust and dynamic decision-making under uncertainty and game theoretic analysis for large-scale transportation and logistics systems; combining tools from data-driven optimization, statistics, simulation and machine learning. Her research is funded by an integrative National Science Foundation grant, a Department of Homeland Security cyber-security grant, the Department of Transportation, the US-India Educational Foundation, the INFORMS Transportation and Logistics Society and aviation companies. Her work has received an Honorable mention for the Anna Valicek award from AGIFORS, a best presentation award from AGIFORS, a KDD Startup Research award, and a Top-10 cited paper recognition from Transportation Research – Part A.

1123 LBME is room 1123 in the Ann & Robert H. Lurie Biomedical Engineering Building (LBME). The street address is 1101 Beal Avenue. A map and directions are available at: https://bme.umich.edu/about/maps-directions/.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach.

For additional information and to be added to the weekly e-mail for the series, please contact genehkim@umich.edu.

Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Thu, 07 Nov 2019 15:23:33 -0500 2019-11-11T16:30:00-05:00 2019-11-11T18:00:00-05:00 Lurie Biomedical Engineering (formerly ATL) U-M Industrial & Operations Engineering Lecture / Discussion Lavanya Marla, PhD
Bioethics Discussion: Body/Politics (November 12, 2019 7:00pm) https://events.umich.edu/event/52721 52721-12974153@events.umich.edu Event Begins: Tuesday, November 12, 2019 7:00pm
Location: Lurie Biomedical Engineering
Organized By: The Bioethics Discussion Group

A discussion on government.

Readings to consider:
1. Bioethics as Politics
2. ‘Fat Ethics’: The Obesity Discourse and Body Politics
3. HB 481
4. A Man, Burning: Communicative Suffering and the Ethics of Images

For more information and/or to receive a copy of the readings contact Barry Belmont at belmont@umich.edu or visit http://belmont.bme.umich.edu/bioethics-discussion-group/discussions/035-body-politics/.

Be it resolved that the policy of this group is to read the blog: https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Tue, 13 Aug 2019 10:52:51 -0400 2019-11-12T19:00:00-05:00 2019-11-12T20:30:00-05:00 Lurie Biomedical Engineering The Bioethics Discussion Group Lecture / Discussion Body/politics
Veterans Week - Suicide Prevention in Veteran and Military Service Members (November 13, 2019 2:30pm) https://events.umich.edu/event/68516 68516-17094817@events.umich.edu Event Begins: Wednesday, November 13, 2019 2:30pm
Location: Michigan League
Organized By: Veteran and Military Services

The rate of suicide was 2.2 times higher among female veterans than their civilian counterparts. The suicide rate is 1.3 times higher among male veterans than their civilian counterparts. The suicide rate is highest for those between the ages of 18-35 and those over 55. An estimated 22 veterans kill themselves every day.

With those alarming and disturbing statistics in mind, come and learn what the Ann Arbor VA is doing to lower the rate of suicide attempts and suicides among the veterans that it sees. Also we will discuss steps the Ann Arbor VA is taking to reach more veterans and military families that are in critical need of mental health care to try to reduce the risk of suicide.

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Lecture / Discussion Thu, 17 Oct 2019 09:41:42 -0400 2019-11-13T14:30:00-05:00 2019-11-13T16:00:00-05:00 Michigan League Veteran and Military Services Lecture / Discussion Veterans Crisis Line
Department of Computational Medicine & Bioinformatics Seminar (November 13, 2019 4:00pm) https://events.umich.edu/event/68641 68641-17128443@events.umich.edu Event Begins: Wednesday, November 13, 2019 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Talk Title: Reproducibility with high-dimensional data

Abstract: With the expanding generation of large-scale biological datasets, there has been an ever-greater concern in understanding the reproducibility of discoveries and findings in a statistically reliable manner. We review several concepts in reproducibility and describe how one can adopt a multiple testing perspective on the problem. This leads to an intuitive procedure for assessing reproducibility. We demonstrate application of the methodology using RNA-sequencing data as well as metabolomics datasets. We will also outline some further problems in the field.

This is joint work with Daisy Philtron, Yafei Lyu and Qunhua Li (Penn State) and Tusharkanti Ghosh, Weiming Zhang and Katerina Kechris (University of Colorado).

DCMB Faculty Host: Alla Karnovsky, PhD

3:45 p.m. - Light Refreshments
4:00 p.m. - Lecture

BlueJeans Live Streaming: https://primetime.bluejeans.com/a2m/live-event/rbuvycdc

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Lecture / Discussion Mon, 21 Oct 2019 11:05:22 -0400 2019-11-13T16:00:00-05:00 2019-11-13T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
Medical Ethics on the Border: A Look at Immigration Detention (November 13, 2019 4:00pm) https://events.umich.edu/event/68151 68151-17018323@events.umich.edu Event Begins: Wednesday, November 13, 2019 4:00pm
Location: University Hospitals
Organized By: Eisenberg Family Depression Center

The community is invited to join the Michigan Medicine Department of Psychiatry for the 24th Annual Waggoner Lecture on Ethics & Values in Medicine. The title of this year’s talk is “Medical Ethics on the Border: A Look at Immigration Detention.” The talk will be presented by Pamela K. McPherson, M.D., FAPAon Wednesday, November 13 from 4:00 – 5:30 p.m. in Ford Auditorium at University Hospital.

Pamela K. McPherson, M.D., FAPA is a medical doctor triple-boarded in general, child and adolescent, and forensic psychiatry. She is a child and adolescent psychiatrist at the Shreveport Behavioral Health Clinic, a gratis assistant professor at Louisiana State University Health Sciences Center Shreveport, and a mental health subject matter expert for the Office of Civil Rights and Civil Liberties at the Department of Homeland Security. Dr. McPherson focuses her research on the mental health of justice-involved youth as well as conditions of juvenile confinement, and consults for the U.S. government and non-profits on mental health services for justice-involved youth.

In 2018, she and colleague Dr. Scott A. Allen exposed the serious health risks to children who are separated from their parents and detained as part of the U.S. administration’s zero tolerance policy at the southern border. Learn more about their work from this CNN article published in May: These doctors risked their careers to expose the dangers children face in immigrant family detention.

“We are delighted to welcome Dr. McPherson to our campus in November for this esteemed lectureship,” said Debra A. Pinals, M.D., clinical professor of psychiatry and director of the Program in Psychiatry, Law and Ethics at U-M and chair of the Waggoner Lectureship Committee. “Dr. McPherson has incredible insight into the conditions of immigrants entering the United States. She could not be better suited to address our campus for this lecture devoted to medical ethics and values in medicine.”

The University of Michigan Department of Psychiatry established the Raymond W. Waggoner Lectureship on Ethics and Values in Medicine in 1996. This lectureship was created in honor of the late Dr. Waggoner, emeritus professor and past chairman of the Department of Psychiatry, who throughout his career and to all who knew him, exemplified the highest standards of integrity and ethics.

The lectureship is an annual event to recognize Dr. Waggoner’s enormous contributions to the Michigan Medicine medical center and to the profession, and to promulgate his interest in medical ethics.

For more information, please contact:

Debra A. Pinals, M.D.

Clinical Professor of Psychiatry

dpinals@med.umich.edu

or

Sandra Bigler

Administrative Assistant Senior to Debra A. Pinals, M.D.

sabigler@med.umich.edu

734-647-8762

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Lecture / Discussion Tue, 08 Oct 2019 10:52:52 -0400 2019-11-13T16:00:00-05:00 2019-11-13T18:00:00-05:00 University Hospitals Eisenberg Family Depression Center Lecture / Discussion 2019 Waggoner Lecture
Veterans Week - Assessment and Treatment of Post Traumatic Stress in Today's Veterans (November 15, 2019 11:30am) https://events.umich.edu/event/68513 68513-17094816@events.umich.edu Event Begins: Friday, November 15, 2019 11:30am
Location: Michigan League
Organized By: Veteran and Military Services

What is PTSD? How is it diagnosed? What are the treatment and caregiving options? What are the outcomes both short-term and long-term for veterans with PTSD? What is Post Traumatic Growth? How does gender affect PTSD manifestations and outcomes? These are some of the questions that the Ann Arbor VA Hospital looks to find answers for. Come and hear about the latest research and studies involving PTSD and treatments from Sarah Richards, one of the leaders in the Ann Arbor PTSD Clinical Team.

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Lecture / Discussion Thu, 17 Oct 2019 08:58:59 -0400 2019-11-15T11:30:00-05:00 2019-11-15T12:30:00-05:00 Michigan League Veteran and Military Services Lecture / Discussion PTSD in Veterans and Servicemembers
Spirituality and Healthcare: Lessons from Fred (November 15, 2019 12:00pm) https://events.umich.edu/event/68542 68542-17096949@events.umich.edu Event Begins: Friday, November 15, 2019 12:00pm
Location:
Organized By: The University of Michigan Medical School Program on Health, Spirituality and Religion

The Woll Family Speaker Series on Health, Spirituality and Religion and the Department of Internal Medicine present Daniel Sulmasy, MD, PhD, Acting Director, Senior Research Scholar, Andre Hellegers Professor of Biomedical Ethics, Georgetown Univeristy

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Workshop / Seminar Thu, 17 Oct 2019 13:47:19 -0400 2019-11-15T12:00:00-05:00 2019-11-15T13:00:00-05:00 The University of Michigan Medical School Program on Health, Spirituality and Religion Workshop / Seminar
Project Management Certification (November 17, 2019 11:00am) https://events.umich.edu/event/61540 61540-15126019@events.umich.edu Event Begins: Sunday, November 17, 2019 11:00am
Location: Ross School of Business
Organized By: Tauber Institute for Global Operations

Once again, the Tauber Institute, in conjunction with the International Project Management Association (IPMA), is sponsoring a Project Management certification class and exam for graduate business and engineering students and staff.

In order to participate, you will need to reflect upon a project management experience (for example: a work project, an engineering design experience/senior capstone, Ross' MAP project, Tauber team project, etc). If you cannot make it to the classes (due to project travel, MAP, or other another class), the sessions will be recorded. Homework (mastery verification) will be required after each session.

The cost to an individual to take the exam is normally $595, however, Tauber is offering the exam at a substantial discount to non-Tauber students: $500 and to Tauber students: $150. Certification is valid for 5 years. Three certification classes will be taught by Professor Eric Svaan on the following dates:

Sunday, March 24 (1:00 - 4:30 pm, Ross 0240)
Sunday, April 7 (1:00 - 4:30 pm, Ross 0240)
Sunday, October 6 (1:00 - 4:30 pm, Ross 0240)

The certification exam, administered by IPMA-USA is scheduled for November 17, 2019 (11:00 - 3:00 pm) at the Ross School of Business. Successfully passing the exam will yield IPMA's Level D certification (Certified Project Management Associate).

Over the last two years, all students who have taken the exam have passed!

Project Management is a powerful skill set to have in your toolbox as you look for full-time employment!

REGISTRATION: Please register through iMpact by clicking here:
https://tauber.umich.edu/events-training/project-management-certification/2019-03-24/project-management-certification-2019

NOTE: The $500 (for non-Tauber students) or $150 fee (for Tauber students) is non-refundable.

HOSTED BY: Tauber Institute for Global Operations. For questions about this event, please contact tauberinstitute@umich.edu or visit tauber.umich.edu.

What is IPMA Level D® (Certified Project Management Associate)? The IPMA Level D is an internationally recognized entry-level qualification in the area of project management. This designation, which demonstrates the individual's ability to understand the basics of project management, is similar to the exam-oriented, knowledge-based certifications of other major Project Management associations. For many, Level D® is the first step towards a professional project or program manager role. It is the first step in a sequence (C, B and A) to be earned by demonstration of success in larger PM responsibility sets.

For more information,
Visit tauber.umich.edu or call 734-647-1333
Connect via email to Diana Crossley dianak@umich.edu

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Class / Instruction Mon, 25 Feb 2019 10:40:05 -0500 2019-11-17T11:00:00-05:00 2019-11-17T15:00:00-05:00 Ross School of Business Tauber Institute for Global Operations Class / Instruction Photo of certificate
Healthcare Engineering & Patient Safety Symposium (November 18, 2019 5:00pm) https://events.umich.edu/event/68251 68251-17035296@events.umich.edu Event Begins: Monday, November 18, 2019 5:00pm
Location: Lurie Robert H. Engin. Ctr
Organized By: U-M Industrial & Operations Engineering

Please join us to learn more about how the Center for Healthcare Engineering and Patient Safety (CHEPS) is improving the safety and quality of healthcare delivery by identifying, fostering, and promoting collaborative projects across the University.

Come enjoy refreshments, networking with colleagues and potential collaborators, poster presentations on cutting-edge healthcare research, and the opportunity to learn about current activities at CHEPS.

For questions, please email cheps-contact@umich.edu.

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Conference / Symposium Mon, 14 Oct 2019 08:08:35 -0400 2019-11-18T17:00:00-05:00 2019-11-18T19:30:00-05:00 Lurie Robert H. Engin. Ctr U-M Industrial & Operations Engineering Conference / Symposium A collage of images from past CHEPS symposia.
BIONIC Lunch: Precision Health (November 19, 2019 12:00pm) https://events.umich.edu/event/63778 63778-15873596@events.umich.edu Event Begins: Tuesday, November 19, 2019 12:00pm
Location: North Campus Research Complex Building 10
Organized By: The Bioethics Discussion Group

Join us for a lunchtime discussion honing in on the ever truer you.

Please RSVP: https://forms.gle/Zxqo17yGh4PUB46cA

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Lecture / Discussion Mon, 23 Sep 2019 14:00:36 -0400 2019-11-19T12:00:00-05:00 2019-11-19T13:30:00-05:00 North Campus Research Complex Building 10 The Bioethics Discussion Group Lecture / Discussion Precision Health
Dissonance Event Series: Protecting Patient Privacy in Big Data (November 19, 2019 6:00pm) https://events.umich.edu/event/69146 69146-17252912@events.umich.edu Event Begins: Tuesday, November 19, 2019 6:00pm
Location: Michigan League
Organized By: Information and Technology Services (ITS)

Join us on Tuesday, November 19, at 6 p.m., for an exciting Dissonance event: Protecting Patient Privacy in Big Data. This panel discussion will take place in the Vandenberg Room, on the second floor of the Michigan League on the UM-Ann Arbor campus. There is no charge for this event and no need to register.

Electronic health records, connected medical devices, health tracking applications, and more have led to a tidal wave of medical data. How this data is being used to transform patient care, improve care quality and decrease healthcare costs, however, is not always evident. Michigan Medicine physicians and legal scholars will explore how medical care will change as digital health platforms evolve, the legal ramifications we might have to navigate, and the privacy and ethical issues that are unfolding today.

- Dr. Brahmajee Nallamothu, Professor, Michigan Medicine (moderator)
- Dr. Jessica Golbus, House Officer, Michigan Medicine
- Prof. Nicholson Price, Professor, U-M Law School
- Dr. Hamid Ghanbari, Clinical Lecturer, Michigan Medicine
- Prof. Kayte Spector-Bagdady, Assistant Professor, U-M Medical School, Chief of the Research Ethics Service in the Center for Bioethics and Social Sciences in Medicine (CBSSM)
- Dr. Sachin Kheterpal, Associate Dean for Research Information Technology, Associate Professor, Michigan Medicine

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Lecture / Discussion Wed, 13 Nov 2019 11:29:44 -0500 2019-11-19T18:00:00-05:00 2019-11-19T19:15:00-05:00 Michigan League Information and Technology Services (ITS) Lecture / Discussion Dissonance Event: Protecting Patient Privacy in Big Data
Neuroscience Speaker Event (November 19, 2019 7:00pm) https://events.umich.edu/event/69290 69290-17299775@events.umich.edu Event Begins: Tuesday, November 19, 2019 7:00pm
Location: Mason Hall
Organized By: Huntington's Disease Awareness Association

A talk about Huntington's disease genetics, clinical signs and symptoms, limitations of current therapeutics, and exciting new developments in disease modification with ASOs and CRISPR technologies.

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Presentation Mon, 11 Nov 2019 09:48:32 -0500 2019-11-19T19:00:00-05:00 2019-11-19T20:00:00-05:00 Mason Hall Huntington's Disease Awareness Association Presentation HDAA at UMich
Professional Autobiography (November 19, 2019 8:00pm) https://events.umich.edu/event/69010 69010-17213804@events.umich.edu Event Begins: Tuesday, November 19, 2019 8:00pm
Location: 1100 North University Building
Organized By: HSSP

Have you ever wondered how health care professionals end up in their careers? Professional Autobiographies are excellent opportunities for students to hear directly from health care professionals in an informal setting. During these talks, students will learn about speakers' motivations for their career choices, how their interests and experiences influenced their career trajectories, and how they’ve worked to align their passion(s) with their work. These sessions provide an excellent opportunity to connect with professionals who may be able to provide valuable advice during your Michigan career.

All HSSP-sponsored Professional Autobiographies are open to the public.

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Lecture / Discussion Thu, 31 Oct 2019 13:56:26 -0400 2019-11-19T20:00:00-05:00 2019-11-19T21:00:00-05:00 1100 North University Building HSSP Lecture / Discussion Timothy R.B. Johnson, MD
DCMB Weekly Seminar (November 20, 2019 4:00pm) https://events.umich.edu/event/68972 68972-17205312@events.umich.edu Event Begins: Wednesday, November 20, 2019 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract: GWAS of neuropsychiatric diseases have identified many loci, however, causal variants often remain unknown. We performed ATAC-seq in human iPSC-derived neurons, and identified thousands of variants affecting chromatin accessibility. Such variants are highly enriched with risk variants of a range of brain disorders. We computationally fine-mapped causal variants and experimentally tested their activities using CRISPRi followed by single cell RNA-seq. Our work provides a framework for prioritizing noncoding disease variants.

The second part of my talk will be focused on genetics of N6-methyladenosine (m6A), a common form of mRNA modification. m6A plays an important role in regulating various aspects of mRNA metabolism in eukaryotes. However, little is known about how DNA sequence variations may affect the m6A modification and the role of m6A in common diseases. We mapped genetic variants associated with m6A levels in 60 Yoruba lymphoblast cell lines. By leveraging these variants, our analysis provides novel insights of mechanisms regulating m6A installation, and downstream effects of m6A on other molecular traits such as translation rate. Integrated analysis with GWAS data reveals m6A variation as an important mechanism linking genetic variations to complex diseases.

BlueJeans livestreaming link: https://primetime.bluejeans.com/a2m/live-event/rbuvycdc

3:45 p.m. - Light Refreshments
4:00 p.m. - Lecture

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Lecture / Discussion Wed, 30 Oct 2019 12:51:34 -0400 2019-11-20T16:00:00-05:00 2019-11-20T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
Between Life and Death: The Cultural Politics of Modern Spanish Medicine, 1770-1808 (November 21, 2019 4:00pm) https://events.umich.edu/event/67229 67229-16828980@events.umich.edu Event Begins: Thursday, November 21, 2019 4:00pm
Location: Modern Languages Building
Organized By: Medieval and Early Modern Studies (MEMS)

In 1770, Charles III of Spain issued a royal decree to overhaul the university system throughout his kingdom. As part of this overhaul, a range of reforms were instituted to modernize anatomical and medical studies thereby placing Spanish science on a more secure footing with the rest of Europe. During this period of transformation, the study of life and death and the emergence of new developments in the practice of resuscitation opened promising avenues of research for exploring the wonders of the human body. Yet, as Fernández-Medina will argue through the work of some of Spain’s foremost physicians and thinkers, it also sparked one of the fiercest debates in the Spanish Enlightenment on the expansion of scientific knowledge and its role in modern society.

Professor Fernández-Medina specializes in late eighteenth- to early twentieth-century Spanish literature, philosophy, and intellectual history, including Enlightenment thought, philosophy of science and the body, social history of ideas in medicine, modernist aesthetics, and the avant-garde.

He is the author of Life Embodied: The Promise of Vital Force in Spanish Modernity (McGill-Queen’s UP, 2018), Modernism and the Avant-garde Body in Spain and Italy (co-edited with Maria Truglio, New York: Routledge, 2016), and The Poetics of Otherness in Antonio Machado’s ‘Proverbios y cantares’ (U of Wales P, 2011). His current book, Raising the Dead: The Science and Literature of Resuscitation in Spain explores Spanish modernity’s unending fascination with the life/death divide and analyzes the numerous social narratives of existence and mortality that have shaped Spain’s cultural imaginary.

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Lecture / Discussion Thu, 14 Nov 2019 11:00:22 -0500 2019-11-21T16:00:00-05:00 2019-11-21T18:00:00-05:00 Modern Languages Building Medieval and Early Modern Studies (MEMS) Lecture / Discussion Between Life and Death: The Cultural Politics of Modern Spanish Medicine, 1770-1808
RNA Innovation Seminar, Kristian Baker, Case Western (November 25, 2019 4:00pm) https://events.umich.edu/event/65142 65142-16541442@events.umich.edu Event Begins: Monday, November 25, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Kristian E. Baker, Ph.D. (Principle Investigator), Center for RNA Molecular Biology, Case Western Reserve University

Abstract: The nonsense-mediated mRNA decay pathway in eukaryotes serves as an RNA quality control system to protect cells from persistent expression of C-terminally truncated polypeptides as a consequence of premature translation termination at nonsense codons. How the cell defines a translation termination event as premature and, subsequently, how this information is communicated to the decay machinery so as to accelerate the degradation of the mRNA remain unclear. We have previously shown that mutations within UPF1 - a member of the SF1 helicase superfamily and a core component of the NMD machinery - which inactivate its ATPase activity give rise to RNA decay intermediates that accumulate due to stalling of ribosomes at or near the premature termination codon. These findings revealed a key functional interaction between the translation apparatus and NMD machinery, and signify that ATP hydrolysis by UPF1 targets the ribosome to facilitate peptide hydrolysis and/or ribosome recycling during translation termination.
My lab’s ongoing efforts directed at dissecting the how UPF1 impacts premature translation termination will be presented.

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Lecture / Discussion Thu, 24 Oct 2019 12:52:12 -0400 2019-11-25T16:00:00-05:00 2019-11-25T17:00:00-05:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion flyer
IOE 813 Seminar: Armagan Bayram, PhD (November 25, 2019 4:30pm) https://events.umich.edu/event/69641 69641-17374460@events.umich.edu Event Begins: Monday, November 25, 2019 4:30pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: U-M Industrial & Operations Engineering

Virtual appointments between patients and healthcare providers can offer a cost-effective alternative to traditional office appointments for managing chronic conditions. Virtual appointments increase contact with the physician by either substituting or complementing office appointments, leading to improved health outcomes. The true value of virtual appointments cannot be realized until they are truly integrated with the office appointment systems. In this study, we introduce a capacity allocation model to study the use of virtual appointments in a chronic care setting. Specifically, we develop a finite horizon stochastic dynamic program to determine which patients to schedule for office and virtual appointments that maximizes aggregate health benefits across a cohort of patients. Optimal policy characterization for this problem is challenging. We find that under certain conditions, a myopic heuristic, where the sickest patients are scheduled for office appointments and the next sickest patients are scheduled for virtual appointments, is optimal. We show that the myopic heuristic performs well even in more general settings. Our findings further show that virtual appointments serve a dual purpose: they may reduce the number of office appointments and may trigger follow-up office appointments.

Dr. Armagan Bayram is an assistant professor in the Department of Industrial and Manufacturing Systems Engineering at University of Michigan – Dearborn. She worked as a postdoctoral fellow in the Department of Industrial Engineering and Management Sciences at Northwestern University. She received her Ph.D. in Management Science from the University of Massachusetts Amherst and M.S. and B.S. degrees in Industrial Engineering from Istanbul Technical University. Dr. Bayram’s research interests include the development of stochastic models and solution methods for capacity and resource allocation problems. Of particular interest are stochastic optimization and dynamic programming models that involve nonprofit and healthcare applications.

1123 LBME is room 1123 in the Ann & Robert H. Lurie Biomedical Engineering Building (LBME). The street address is 1101 Beal Avenue. A map and directions are available at: http://www.bme.umich.edu/about/directions.php.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach.

For additional information and to be added to the weekly e-mail for the series, please contact genehkim@umich.edu.

Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Wed, 20 Nov 2019 10:45:52 -0500 2019-11-25T16:30:00-05:00 2019-11-25T18:00:00-05:00 Lurie Biomedical Engineering (formerly ATL) U-M Industrial & Operations Engineering Lecture / Discussion Center for Healthcare Engineering & Patient Safety
Online Trade Show: Integrated Product Development: Healthy 20-30 Year Old's (November 26, 2019 2:00pm) https://events.umich.edu/event/69730 69730-17392921@events.umich.edu Event Begins: Tuesday, November 26, 2019 2:00pm
Location:
Organized By: Tauber Institute for Global Operations

University of Michigan’s Art & Design, Business, Engineering, and School of Information students are gearing up for the 25th offering of the Integrated Product Development (IPD) Trade Show! Members of our community will gather to view and make purchase decisions from the “best of the best” of their work over the past semester in this interdisciplinary course.

IPD is an experiential, cross-disciplinary course that puts teams of students from Art & Design, Business, Engineering, and Information in a competitive product development environment. This innovative course has been featured on CNN and written up in the New York Times, Wall Street Journal and Businessweek. The course is hosted by the Tauber Institute for Global Operations, and is taught jointly by faculty members Eric Svaan of the Stephen M. Ross School of Business and Stephanie Tharp from the Penny W. Stamps School of Art & Design.

The Problem Statement: to design and produce a tangible product suitable for use by working adults, which may be used to build healthy living habits, so as to improve quality of life, health maintenance and outcomes.

View the products online. Then cast your vote!

ONLINE VOTING BEGINS Nov. 26th:
https://tauber.umich.edu/events-training/integrated-product-development/2019-12-04/25th-integrated-product-development-trade

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Exhibition Mon, 02 Dec 2019 07:36:32 -0500 2019-11-26T14:00:00-05:00 2019-11-26T14:00:00-05:00 Tauber Institute for Global Operations Exhibition 2019 Online IPD Trade Show
Online Trade Show: Integrated Product Development: Healthy 20-30 Year Old's (November 27, 2019 2:00pm) https://events.umich.edu/event/69730 69730-17392922@events.umich.edu Event Begins: Wednesday, November 27, 2019 2:00pm
Location:
Organized By: Tauber Institute for Global Operations

University of Michigan’s Art & Design, Business, Engineering, and School of Information students are gearing up for the 25th offering of the Integrated Product Development (IPD) Trade Show! Members of our community will gather to view and make purchase decisions from the “best of the best” of their work over the past semester in this interdisciplinary course.

IPD is an experiential, cross-disciplinary course that puts teams of students from Art & Design, Business, Engineering, and Information in a competitive product development environment. This innovative course has been featured on CNN and written up in the New York Times, Wall Street Journal and Businessweek. The course is hosted by the Tauber Institute for Global Operations, and is taught jointly by faculty members Eric Svaan of the Stephen M. Ross School of Business and Stephanie Tharp from the Penny W. Stamps School of Art & Design.

The Problem Statement: to design and produce a tangible product suitable for use by working adults, which may be used to build healthy living habits, so as to improve quality of life, health maintenance and outcomes.

View the products online. Then cast your vote!

ONLINE VOTING BEGINS Nov. 26th:
https://tauber.umich.edu/events-training/integrated-product-development/2019-12-04/25th-integrated-product-development-trade

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Exhibition Mon, 02 Dec 2019 07:36:32 -0500 2019-11-27T14:00:00-05:00 2019-11-27T14:00:00-05:00 Tauber Institute for Global Operations Exhibition 2019 Online IPD Trade Show
Online Trade Show: Integrated Product Development: Healthy 20-30 Year Old's (November 28, 2019 2:00pm) https://events.umich.edu/event/69730 69730-17392923@events.umich.edu Event Begins: Thursday, November 28, 2019 2:00pm
Location:
Organized By: Tauber Institute for Global Operations

University of Michigan’s Art & Design, Business, Engineering, and School of Information students are gearing up for the 25th offering of the Integrated Product Development (IPD) Trade Show! Members of our community will gather to view and make purchase decisions from the “best of the best” of their work over the past semester in this interdisciplinary course.

IPD is an experiential, cross-disciplinary course that puts teams of students from Art & Design, Business, Engineering, and Information in a competitive product development environment. This innovative course has been featured on CNN and written up in the New York Times, Wall Street Journal and Businessweek. The course is hosted by the Tauber Institute for Global Operations, and is taught jointly by faculty members Eric Svaan of the Stephen M. Ross School of Business and Stephanie Tharp from the Penny W. Stamps School of Art & Design.

The Problem Statement: to design and produce a tangible product suitable for use by working adults, which may be used to build healthy living habits, so as to improve quality of life, health maintenance and outcomes.

View the products online. Then cast your vote!

ONLINE VOTING BEGINS Nov. 26th:
https://tauber.umich.edu/events-training/integrated-product-development/2019-12-04/25th-integrated-product-development-trade

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Exhibition Mon, 02 Dec 2019 07:36:32 -0500 2019-11-28T14:00:00-05:00 2019-11-28T14:00:00-05:00 Tauber Institute for Global Operations Exhibition 2019 Online IPD Trade Show
Online Trade Show: Integrated Product Development: Healthy 20-30 Year Old's (November 29, 2019 2:00pm) https://events.umich.edu/event/69730 69730-17392924@events.umich.edu Event Begins: Friday, November 29, 2019 2:00pm
Location:
Organized By: Tauber Institute for Global Operations

University of Michigan’s Art & Design, Business, Engineering, and School of Information students are gearing up for the 25th offering of the Integrated Product Development (IPD) Trade Show! Members of our community will gather to view and make purchase decisions from the “best of the best” of their work over the past semester in this interdisciplinary course.

IPD is an experiential, cross-disciplinary course that puts teams of students from Art & Design, Business, Engineering, and Information in a competitive product development environment. This innovative course has been featured on CNN and written up in the New York Times, Wall Street Journal and Businessweek. The course is hosted by the Tauber Institute for Global Operations, and is taught jointly by faculty members Eric Svaan of the Stephen M. Ross School of Business and Stephanie Tharp from the Penny W. Stamps School of Art & Design.

The Problem Statement: to design and produce a tangible product suitable for use by working adults, which may be used to build healthy living habits, so as to improve quality of life, health maintenance and outcomes.

View the products online. Then cast your vote!

ONLINE VOTING BEGINS Nov. 26th:
https://tauber.umich.edu/events-training/integrated-product-development/2019-12-04/25th-integrated-product-development-trade

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Exhibition Mon, 02 Dec 2019 07:36:32 -0500 2019-11-29T14:00:00-05:00 2019-11-29T14:00:00-05:00 Tauber Institute for Global Operations Exhibition 2019 Online IPD Trade Show
Online Trade Show: Integrated Product Development: Healthy 20-30 Year Old's (November 30, 2019 2:00pm) https://events.umich.edu/event/69730 69730-17392925@events.umich.edu Event Begins: Saturday, November 30, 2019 2:00pm
Location:
Organized By: Tauber Institute for Global Operations

University of Michigan’s Art & Design, Business, Engineering, and School of Information students are gearing up for the 25th offering of the Integrated Product Development (IPD) Trade Show! Members of our community will gather to view and make purchase decisions from the “best of the best” of their work over the past semester in this interdisciplinary course.

IPD is an experiential, cross-disciplinary course that puts teams of students from Art & Design, Business, Engineering, and Information in a competitive product development environment. This innovative course has been featured on CNN and written up in the New York Times, Wall Street Journal and Businessweek. The course is hosted by the Tauber Institute for Global Operations, and is taught jointly by faculty members Eric Svaan of the Stephen M. Ross School of Business and Stephanie Tharp from the Penny W. Stamps School of Art & Design.

The Problem Statement: to design and produce a tangible product suitable for use by working adults, which may be used to build healthy living habits, so as to improve quality of life, health maintenance and outcomes.

View the products online. Then cast your vote!

ONLINE VOTING BEGINS Nov. 26th:
https://tauber.umich.edu/events-training/integrated-product-development/2019-12-04/25th-integrated-product-development-trade

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Exhibition Mon, 02 Dec 2019 07:36:32 -0500 2019-11-30T14:00:00-05:00 2019-11-30T14:00:00-05:00 Tauber Institute for Global Operations Exhibition 2019 Online IPD Trade Show
Online Trade Show: Integrated Product Development: Healthy 20-30 Year Old's (December 1, 2019 2:00pm) https://events.umich.edu/event/69730 69730-17392926@events.umich.edu Event Begins: Sunday, December 1, 2019 2:00pm
Location:
Organized By: Tauber Institute for Global Operations

University of Michigan’s Art & Design, Business, Engineering, and School of Information students are gearing up for the 25th offering of the Integrated Product Development (IPD) Trade Show! Members of our community will gather to view and make purchase decisions from the “best of the best” of their work over the past semester in this interdisciplinary course.

IPD is an experiential, cross-disciplinary course that puts teams of students from Art & Design, Business, Engineering, and Information in a competitive product development environment. This innovative course has been featured on CNN and written up in the New York Times, Wall Street Journal and Businessweek. The course is hosted by the Tauber Institute for Global Operations, and is taught jointly by faculty members Eric Svaan of the Stephen M. Ross School of Business and Stephanie Tharp from the Penny W. Stamps School of Art & Design.

The Problem Statement: to design and produce a tangible product suitable for use by working adults, which may be used to build healthy living habits, so as to improve quality of life, health maintenance and outcomes.

View the products online. Then cast your vote!

ONLINE VOTING BEGINS Nov. 26th:
https://tauber.umich.edu/events-training/integrated-product-development/2019-12-04/25th-integrated-product-development-trade

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Exhibition Mon, 02 Dec 2019 07:36:32 -0500 2019-12-01T14:00:00-05:00 2019-12-01T14:00:00-05:00 Tauber Institute for Global Operations Exhibition 2019 Online IPD Trade Show
Online Trade Show: Integrated Product Development: Healthy 20-30 Year Old's (December 2, 2019 2:00pm) https://events.umich.edu/event/69730 69730-17392927@events.umich.edu Event Begins: Monday, December 2, 2019 2:00pm
Location:
Organized By: Tauber Institute for Global Operations

University of Michigan’s Art & Design, Business, Engineering, and School of Information students are gearing up for the 25th offering of the Integrated Product Development (IPD) Trade Show! Members of our community will gather to view and make purchase decisions from the “best of the best” of their work over the past semester in this interdisciplinary course.

IPD is an experiential, cross-disciplinary course that puts teams of students from Art & Design, Business, Engineering, and Information in a competitive product development environment. This innovative course has been featured on CNN and written up in the New York Times, Wall Street Journal and Businessweek. The course is hosted by the Tauber Institute for Global Operations, and is taught jointly by faculty members Eric Svaan of the Stephen M. Ross School of Business and Stephanie Tharp from the Penny W. Stamps School of Art & Design.

The Problem Statement: to design and produce a tangible product suitable for use by working adults, which may be used to build healthy living habits, so as to improve quality of life, health maintenance and outcomes.

View the products online. Then cast your vote!

ONLINE VOTING BEGINS Nov. 26th:
https://tauber.umich.edu/events-training/integrated-product-development/2019-12-04/25th-integrated-product-development-trade

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Exhibition Mon, 02 Dec 2019 07:36:32 -0500 2019-12-02T14:00:00-05:00 2019-12-02T14:00:00-05:00 Tauber Institute for Global Operations Exhibition 2019 Online IPD Trade Show
RNA Innovation Seminar, Auinash Kalsotra, University of Illinois at Urbana-Champaign (December 2, 2019 4:00pm) https://events.umich.edu/event/65143 65143-16541443@events.umich.edu Event Begins: Monday, December 2, 2019 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Auinash Kalsotra, PhD, Associate Professor of Biochemistry, Affiliate, Institute for Genomic Biology, University of Illinois at Urbana-Champaign

Abstract: For many genes, steady-state messenger (m)RNA levels provide an inaccurate reflection of the extent to which they are translated into proteins. This seminar will focus on post-transcriptional mechanisms that affect the “quality” and “quantity” of RNAs produced in a cell-type- and context-dependent manner. First, I will describe the identification of a conserved developmentally regulated alternative splicing program that supports terminal differentiation, functional competence, and postnatal maturation of hepatocytes. Second, I will show evidence that following liver injury, this developmental splicing program is transiently re-activated to rewire a critical signaling pathway that enables proper liver regeneration. Third, I will demonstrate that in severe alcoholic hepatitis, the sustained re-activation of this developmental program causes hepatocytes to shed adult functions and become more regenerative but threatens overall survival by populating the liver with functionally-immature cells.

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Lecture / Discussion Thu, 24 Oct 2019 08:55:20 -0400 2019-12-02T16:00:00-05:00 2019-12-02T17:00:00-05:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion flyer
STS Speaker. Civil Rights as Patient Experience: How Healthcare Organizations Handle Complaints (December 2, 2019 4:00pm) https://events.umich.edu/event/66888 66888-16785529@events.umich.edu Event Begins: Monday, December 2, 2019 4:00pm
Location: Tisch Hall
Organized By: Science, Technology & Society

The non-discrimination clause of the Affordable Care Act, known as Section 1557, formally expanded patients’ civil rights in nearly every healthcare setting in the U.S. in 2010. Sex discrimination was a protected category for the first time in healthcare, and the Obama administration interpreted sex discrimination to include transgender discrimination. Regulations required healthcare organizations to name a person to handle grievances and set up an internal grievance process for resolving them. Drawing on interviews with 58 healthcare grievance handlers in four U.S. states about how they process patient complaints, this study examines how medical organizations have responded to expanded patient rights. What does it mean to bring civil rights into U.S. healthcare settings, and what implications are there for transgender healthcare rights in particular? We found a range of approaches to rights in healthcare settings and a dominant approach devoted to patient experience that served to diminish the power of healthcare rights. The project also extends to health insurance problems and coverage for transgender care, religious non-discrimination rules as competing values in healthcare settings, and the Trump administration's efforts to undo the Obama efforts to advance transgender rights.

Bio: Anna Kirkland, J.D., Ph.D., is an Arthur F. Thurnau Professor in Women’s Studies at the University of Michigan. She received her law degree (2001)and Ph.D. in Jurisprudence and Social Policy (2003) from the University of California, Berkeley. Prof. Kirkland served as a committee member on the National Academies panel charged with studying sexual harassment in the STEM fields of academia, published in June 2018 as Sexual Harassment of Women: Climate, Culture, and Consequences in Academic Sciences, Engineering, and Medicine. She is the author of Fat Rights: Dilemmas of Difference and Personhood(New York University Press, 2008), Vaccine Court: The Law and Politics of Injury (NYU 2016), and co-editor with Jonathan Metz lof Against Health: How Health Became the New Morality (New York University Press, 2010).

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Lecture / Discussion Wed, 11 Sep 2019 08:44:40 -0400 2019-12-02T16:00:00-05:00 2019-12-02T17:30:00-05:00 Tisch Hall Science, Technology & Society Lecture / Discussion Tisch Hall
IOE 813 Seminar: Leia Stirling, PhD (December 2, 2019 4:30pm) https://events.umich.edu/event/69766 69766-17417431@events.umich.edu Event Begins: Monday, December 2, 2019 4:30pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: U-M Industrial & Operations Engineering

Wearable sensors provide opportunity to augment occupational therapy through telemedicine. However, there are several design challenges embedded in creating an at-home telemonitoring system that can visualize the complex biomechanical data required for clinical decision making. These challenges include defining performance metrics that correspond to clinical needs and being able to robustly make these measures in a natural environment. In this talk, we describe quantified metrics of motion coordination, balance strategy, and torso compensatory motions. These metrics were informed by clinical observations and were features monitored and synthesized to adapt the selected patient activities.

Leia Stirling is an Associate Professor in Industrial and Operations Engineering at the University of Michigan. Her research quantifies human performance and human-machine fluency to assess performance augmentation, advance exoskeleton control algorithms, mitigate injury risk, and provide relevant feedback to subject matter experts across domains. She received her B.S. (2003) and M.S. (2005) in Aeronautical and Astronautical Engineering from the University of Illinois at Urbana-Champaign, and her Ph.D. (2008) in Aeronautics and Astronautics from MIT. She was a postdoctoral researcher at Boston Children’s Hospital and Harvard Medical School (2008-2009), on the Advanced Technology Team at the Wyss Institute for Biologically Inspired Engineering (2009-2012), then an Assistant Professor at MIT (2013 – 2019). She joined the faculty at the University of Michigan in 2019.

1123 LBME is room 1123 in the Ann & Robert H. Lurie Biomedical Engineering Building (LBME). The street address is 1101 Beal Avenue. A map and directions are available at: http://www.bme.umich.edu/about/directions.php.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach.

For additional information and to be added to the weekly e-mail for the series, please contact genehkim@umich.edu.

Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Mon, 25 Nov 2019 13:25:13 -0500 2019-12-02T16:30:00-05:00 2019-12-02T18:00:00-05:00 Lurie Biomedical Engineering (formerly ATL) U-M Industrial & Operations Engineering Lecture / Discussion Leia Stirling, PhD
DESIGN FOR GLOBAL HEALTH ACADEMIC PROGRAM INFORMATION SESSION (December 2, 2019 6:00pm) https://events.umich.edu/event/69473 69473-17327210@events.umich.edu Event Begins: Monday, December 2, 2019 6:00pm
Location: GG Brown Laboratory
Organized By: Global Health Design Initiative

Students are invited to come learn about the Design for Global Health Academic Program! The UM Global Health Design Initiative (GHDI) application for the Design for Global Health Academic Program is open! This program consists of a 4-8 weeks summer fieldwork experience in Ghana, Kenya, Rwanda, or Michigan to inform a novel design project to be completed during Fall 2020. Participants will gain extensive design experience and exposure to healthcare practices in low-resource settings. This opportunity is open to engineering and non-engineering students with junior or senior standing by Fall 2020. Priority deadline for applications in Dec 4th, 2019.

To learn more about GHDI and to apply, visit https://globalhealthdesign.engin.umich.edu/. Please direct inquiries to globalhealthdesign@umich.edu.

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Careers / Jobs Thu, 14 Nov 2019 14:28:46 -0500 2019-12-02T18:00:00-05:00 2019-12-02T19:00:00-05:00 GG Brown Laboratory Global Health Design Initiative Careers / Jobs Global Health Design Initiative block M logo
Online Trade Show: Integrated Product Development: Healthy 20-30 Year Old's (December 3, 2019 2:00pm) https://events.umich.edu/event/69730 69730-17392928@events.umich.edu Event Begins: Tuesday, December 3, 2019 2:00pm
Location:
Organized By: Tauber Institute for Global Operations

University of Michigan’s Art & Design, Business, Engineering, and School of Information students are gearing up for the 25th offering of the Integrated Product Development (IPD) Trade Show! Members of our community will gather to view and make purchase decisions from the “best of the best” of their work over the past semester in this interdisciplinary course.

IPD is an experiential, cross-disciplinary course that puts teams of students from Art & Design, Business, Engineering, and Information in a competitive product development environment. This innovative course has been featured on CNN and written up in the New York Times, Wall Street Journal and Businessweek. The course is hosted by the Tauber Institute for Global Operations, and is taught jointly by faculty members Eric Svaan of the Stephen M. Ross School of Business and Stephanie Tharp from the Penny W. Stamps School of Art & Design.

The Problem Statement: to design and produce a tangible product suitable for use by working adults, which may be used to build healthy living habits, so as to improve quality of life, health maintenance and outcomes.

View the products online. Then cast your vote!

ONLINE VOTING BEGINS Nov. 26th:
https://tauber.umich.edu/events-training/integrated-product-development/2019-12-04/25th-integrated-product-development-trade

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Exhibition Mon, 02 Dec 2019 07:36:32 -0500 2019-12-03T14:00:00-05:00 2019-12-03T14:00:00-05:00 Tauber Institute for Global Operations Exhibition 2019 Online IPD Trade Show
DESIGN FOR GLOBAL HEALTH ACADEMIC PROGRAM INFORMATION SESSION (December 3, 2019 5:00pm) https://events.umich.edu/event/69476 69476-17327213@events.umich.edu Event Begins: Tuesday, December 3, 2019 5:00pm
Location: Shapiro Library
Organized By: Global Health Design Initiative

Students are invited to come learn about the Design for Global Health Academic Program! The UM Global Health Design Initiative (GHDI) application for the Design for Global Health Academic Program is open! This program consists of a 4-8 weeks summer fieldwork experience in Ghana, Kenya, Rwanda, or Michigan to inform a novel design project to be completed during Fall 2020. Participants will gain extensive design experience and exposure to healthcare practices in low-resource settings. This opportunity is open to engineering and non-engineering students with junior or senior standing by Fall 2020. Priority deadline for applications is December 4th, 2019.

To learn more about GHDI and to apply, visit https://globalhealthdesign.engin.umich.edu/. Please direct inquiries to globalhealthdesign@umich.edu.

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Careers / Jobs Thu, 14 Nov 2019 14:34:20 -0500 2019-12-03T17:00:00-05:00 2019-12-03T18:00:00-05:00 Shapiro Library Global Health Design Initiative Careers / Jobs Global Health Design Initiative block M logo
Trade Show: Integrated Product Development: Healthy 20-30 Year Old's (December 4, 2019 4:30pm) https://events.umich.edu/event/69735 69735-17392937@events.umich.edu Event Begins: Wednesday, December 4, 2019 4:30pm
Location: Ross School of Business
Organized By: Tauber Institute for Global Operations

University of Michigan’s Art & Design, Business, Engineering, and School of Information students are gearing up for the 25th offering of the Integrated Product Development (IPD) Trade Show! Members of our community will gather to view and make purchase decisions from the “best of the best” of their work over the past semester in this interdisciplinary course.

IPD is an experiential, cross-disciplinary course that puts teams of students from Art & Design, Business, Engineering, and Information in a competitive product development environment. This innovative course has been featured on CNN and written up in the New York Times, Wall Street Journal and Businessweek. The course is hosted by the Tauber Institute for Global Operations, and is taught jointly by faculty members Eric Svaan of the Stephen M. Ross School of Business and Stephanie Tharp from the Penny W. Stamps School of Art & Design.

The Problem Statement: to design and produce a tangible product suitable for use by working adults, which may be used to build healthy living habits, so as to improve quality of life, health maintenance and outcomes.

See the actual products and test them out. Then cast your vote! Network, have fun and meet up with friends, old and new!

Parking is street meter or there is public parking available in the Hill Street Structure Parking Garage.

Event is Free and open to the public, with light refreshments.

GREAT LOCATION: Lobby of the Robertson Auditorium, at the Ross School of Business, 1st floor at 701 Tappan, Ann Arbor, MI

ONLINE VOTING BEGINS Nov. 26th:
https://tauber.umich.edu/events-training/integrated-product-development/2019-12-04/25th-integrated-product-development-trade

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Exhibition Mon, 02 Dec 2019 07:35:28 -0500 2019-12-04T16:30:00-05:00 2019-12-04T18:30:00-05:00 Ross School of Business Tauber Institute for Global Operations Exhibition 2019 IPD Trade Show
150 Years of University Hospitals: How U-M Sparked a Revolution (December 6, 2019 12:00pm) https://events.umich.edu/event/69760 69760-17415390@events.umich.edu Event Begins: Friday, December 6, 2019 12:00pm
Location: University Hospitals
Organized By: Michigan Medicine

In December 1869, the first patients entered the first university-owned hospital in America: A converted professor's house on North University Avenue in Ann Arbor.

In the 150 years since then, U-M's academic medical center has grown into one of the largest and most advanced in the world, focusing on providing advanced care, educating biomedical professionals and pursuing research to advance understanding and treatment of human health and disease.

Dr. Joel Howell, co-author of "Medicine at Michigan: A History of the University of Michigan Medical School at the Bicentennial", will speak on the evolution of U-M's own medical enterprise, and how it often set the pace for academic medicine nationwide.

The talk is part of the Grand Rounds series of the Department of Internal Medicine, but is open to all for in-person and online attendance. Watch online at https://primetime.bluejeans.com/a2m/live-event/bfgaveug

This talk represents the beginning of Michigan Medicine's year-long celebration of the 150th anniversary of U-M's academic medical center.

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Lecture / Discussion Mon, 25 Nov 2019 12:25:55 -0500 2019-12-06T12:00:00-05:00 2019-12-06T13:00:00-05:00 University Hospitals Michigan Medicine Lecture / Discussion A photo of the first U-M hospital with its 1876 addition
Ensuring Safe and Equitable Environments for Women in Academic Medicine (December 6, 2019 1:30pm) https://events.umich.edu/event/69405 69405-17318568@events.umich.edu Event Begins: Friday, December 6, 2019 1:30pm
Location: Ross School of Business
Organized By: Interdisciplinary Committee on Organizational Studies - ICOS

Issues of gender equity in the profession of medicine have garnered increased attention in recent years, especially in the wake of the #metoo movement. Some evidence suggests that medicine is exceptional in some ways in comparison to other fields, even within the sciences. For example, a recent report from the US National Academies of Sciences, Engineering, and Medicine suggested that female medical students are 220% more likely than students from non-STEM disciplines to experience sexual harassment. Given the tremendous power and influence of the medical profession, Dr. Jagsi will argue that we must study these issues carefully. Doing so can offer a unique lens with which to understand the broader forces driving inequity in society more generally and help to illuminate possible levers for influencing broader societal attitudes and behaviors. As a scholar whose research has long focused on understanding the mechanisms leading to inequity in the medical profession, Dr. Jagsi will begin by providing an overview of the patterns of women's participation in the profession of medicine. She will then describe studies led by her team and others that have investigated the drivers of women's persistent under-representation among the leaders of the medical profession, even in an era when half of all medical students are female. These include myriad complex challenges, including gendered expectations, unconscious bias, and overt discrimination and harassment. She conclude by discussing innovative interventions that have been implemented to begin the process of cultural transformation in medicine, in the hopes that they may also provide inspiration for initiatives in other settings.

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Lecture / Discussion Wed, 13 Nov 2019 14:20:52 -0500 2019-12-06T13:30:00-05:00 2019-12-06T15:00:00-05:00 Ross School of Business Interdisciplinary Committee on Organizational Studies - ICOS Lecture / Discussion Ross School of Business
“Lessons Learned for Developing an “Exposome” for Children’s Cohort Studies: Challenges and Successes in Applying new Methods for Assessment, Integration, and Analytics” (December 6, 2019 2:00pm) https://events.umich.edu/event/69734 69734-17392934@events.umich.edu Event Begins: Friday, December 6, 2019 2:00pm
Location: School of Public Health Bldg I and Crossroads and Tower
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Dr. Elaine Faustman is a toxicologist and Professor in the UW Department of Environmental & Occupational Health Sciences. She is also Adjunct Professor in the UW Evans School of Public Policy and Governance. One key aim of her research is to understand molecular pathways that control normal brain cell proliferation, differentiation, and apoptosis. Faustman’s group is working to understand the biochemical, molecular, and exposure mechanisms that define children’s susceptibility to environmental chemicals. A focus of her research has been on pesticides and to assess pesticide risks to normal childhood development and learning.M-LEEaD Center Winter Seminar Series

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Workshop / Seminar Fri, 22 Nov 2019 15:34:41 -0500 2019-12-06T14:00:00-05:00 2019-12-06T15:00:00-05:00 School of Public Health Bldg I and Crossroads and Tower Michigan Lifestage Environmental Exposures and Disease Center Workshop / Seminar Faustman Profile
Gene Therapy: Medicine’s Ultimate Frontier (December 6, 2019 3:15pm) https://events.umich.edu/event/64662 64662-16410960@events.umich.edu Event Begins: Friday, December 6, 2019 3:15pm
Location: Off Campus Location
Organized By: Osher Lifelong Learning Institute (50+)

This course will discuss the development of a gene-therapy strategy that enables the human body to fight malignant brain cancer and, potentially, other solid cancers by employing a highly disabled virus to deliver therapeutic cargoes. Genetically engineered viruses (vectors) kill the cancerous tumor cells and elicit an anti-tumor immune response. The presenter will also discuss the preliminary results of the Phase I clinical trial at the University of Michigan – the first-in-human, first-in-the-world clinical trial using two different gene-therapy vectors.
Maria G. Castro, instructor, is the R.C. Schneider Professor of Neurosurgery, Professor of Cell and Developmental Biology, and Program Director of the Cancer Biology Training grant at the University of Michigan Medical School. She dedicates her research to novel treatments for adult and pediatric brain cancer, including immune-mediated gene therapy. This Study Group is for those 50 and over and meets Friday, 3:15–5:15 pm on December 6.

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Class / Instruction Sat, 27 Jul 2019 10:05:42 -0400 2019-12-06T15:15:00-05:00 2019-12-06T17:15:00-05:00 Off Campus Location Osher Lifelong Learning Institute (50+) Class / Instruction Study Group
"Getting to Zero: Religious Leaders as Trusted Messengers for Eliminating HIV/AIDS" (December 9, 2019 12:00pm) https://events.umich.edu/event/69288 69288-17299771@events.umich.edu Event Begins: Monday, December 9, 2019 12:00pm
Location: Taubman Library
Organized By: The University of Michigan Medical School Program on Health, Spirituality and Religion

The Woll Family Speaker Series on Health, Spirituality and Religion present A. Oveta Fuller, PhD., Associate Professor of Microbiology and Immunology

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Workshop / Seminar Mon, 11 Nov 2019 08:48:12 -0500 2019-12-09T12:00:00-05:00 2019-12-09T13:00:00-05:00 Taubman Library The University of Michigan Medical School Program on Health, Spirituality and Religion Workshop / Seminar
IOE 813 Seminar: Amy Cohn, PhD and Krishnan Raghavendran, MBBS (December 9, 2019 4:30pm) https://events.umich.edu/event/70022 70022-17497479@events.umich.edu Event Begins: Monday, December 9, 2019 4:30pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: U-M Industrial & Operations Engineering

Specializing in trauma, burn, surgical critical care, and emergency surgery areas, the surgeons in the Division of Acute Care Surgery at Michigan Medicine care for our most critically injured patients. Ensuring that this team is able to properly staff its units at all times is essential to Michigan Medicine’s mission and role as a Level 1 Trauma Center and Burn Verified Center. However, traditional methods for scheduling healthcare providers are time-intensive and may fail to meet the needs of the providers and units they serve. For Acute Care Surgery, the task of creating the schedules, which often follows a complex set of rules and preferences, falls on the Division Chief, consuming valuable time and sometimes not satisfying each surgeon’s preferences. To improve this process, we have created a computerized decision-making tool to ease the burden of creating such schedules. We formulated an integer program to automate the creation of this department’s six-month-long schedule, which assigns 15 attending surgeons to 5 units for weekly time intervals. Users can input schedule parameters such as the attending surgeons’ time-off requests and targeted number of weeks on service. Moreover, metrics enable generating the highest-quality schedule that simultaneously meets the needs of the department, the surgeons’ preferences, and balances the schedule fairly. This scheduling tool has drastically decreased the production time of the schedule. Whereas previously creating the six-month schedule required multiple weeks of the division chief’s time, using the scheduling tool requires only a few hours of the division chief’s time. Additionally, the transparent schedule metrics defined by the tool can increase a sense of fairness among surgeons, increasing job satisfaction and reducing physician burnout.

Amy Cohn, PhD, joined the faculty in the Department of Industrial and Operations Engineering at the University of Michigan in 2002 as an Assistant Professor and was promoted to Associate Professor in 2009; in 2011, she was also named a Thurnau Professor and in 2017 was promoted to Full Professor. She currently holds the position of Associate Director for the Center for Healthcare Engineering and Patient Safety. Her primary research interest is in robust and integrated planning for large-scale systems, predominantly in healthcare and aviation applications. She also collaborates on projects in satellite communications, vehicle routing problems for hybrid fleets, and robust network design for power systems and related applications. Her primary teaching interest is in optimization techniques, at both the graduate and undergraduate level.

Dr. Raghavendran is Professor of Surgery and the Division chief of Acute Care Surgery, Section of General Surgery. He received his medical education in India and immigrated to the United States in 1991, wherein he completed his Surgical Residency and subsequent fellowship in Surgical Critical Care Dr. Raghavendran has been continuously funded by the National Institutes of Health (NIH) from both NIGMS and NHLBI for the past 14 years. The current R-01 is on the study of Hypoxia-inducible factor 1 α in the pathogenesis of acute inflammatory response following lung contusion. The focus of his clinical interest is with ARDS and ventilator-associated pneumonia.He currently serves as the director of the newly formed Michigan Center for global surgery. Additionally, he serves as the lead physician for the University of Michigan India collaborative. He has also received funding from the NIH US/India collaborative with an R-03 award examining the role of ultrasound and measurement of optic nerve sheath diameter as a surrogate marker for traumatic brain injury.

1123 LBME is room 1123 in the Ann & Robert H. Lurie Biomedical Engineering Building (LBME). The street address is 1101 Beal Avenue. A map and directions are available at: http://www.bme.umich.edu/about/directions.php.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach.

For additional information and to be added to the weekly e-mail for the series, please contact genehkim@umich.edu.

Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Thu, 05 Dec 2019 11:43:02 -0500 2019-12-09T16:30:00-05:00 2019-12-09T18:00:00-05:00 Lurie Biomedical Engineering (formerly ATL) U-M Industrial & Operations Engineering Lecture / Discussion Amy Cohn, PhD and Krishnan Raghavendran, MBBS
Medical School Inside Story (December 9, 2019 5:00pm) https://events.umich.edu/event/65982 65982-16678385@events.umich.edu Event Begins: Monday, December 9, 2019 5:00pm
Location: University Hospitals
Organized By: Science Learning Center

Do you have questions about medical school admissions? Get your answers straight from the inside! U-M Medical School Admissions Director Carol Teener will demystify medical school applications, expectations, and reviews in her presentation.

Please submit your questions via the following link: https://forms.gle/49SpHo8WZLLfuUuR8 by Monday, December 2 and Director Teener will answer as many commonly-asked questions as possible in the allotted hour.

This session will take place in the University of Michigan Hospital's Ford Auditorium.
We recommend that you leave yourself extra time to find the auditorium if you have not been there before!

Registration Link: http://ttc.iss.lsa.umich.edu/undergrad/sessions/medical-school-inside-story-2/

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Workshop / Seminar Wed, 04 Sep 2019 15:41:30 -0400 2019-12-09T17:00:00-05:00 2019-12-09T18:00:00-05:00 University Hospitals Science Learning Center Workshop / Seminar
Special Collections After Hours: Dissecting the Human Body in the Renaissance (December 10, 2019 4:00pm) https://events.umich.edu/event/65052 65052-16509312@events.umich.edu Event Begins: Tuesday, December 10, 2019 4:00pm
Location: Hatcher Graduate Library
Organized By: University Library

The visual representation of human anatomy in the Renaissance was the fruit of an extraordinary partnership between physicians and artists. You are all invited to explore a great variety of early printed books containing illustrations of the human body that reflect the science of dissection as well as the latest artistic theories. The display will include richly illustrated treatises by well-known authors such as Leonardo da Vinci and Andreas Vesalius.

This event is part of Special Collections After Hours, a monthly open house series sharing highlights from the many books, documents, and artifacts in the Special Collections Research Center. Each event is open to everyone and will offer a new group of themed materials for visitors to explore. Open houses are held on the second Tuesday of each month during the academic year. Light refreshments will be provided.

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Reception / Open House Thu, 08 Aug 2019 12:20:14 -0400 2019-12-10T16:00:00-05:00 2019-12-10T18:00:00-05:00 Hatcher Graduate Library University Library Reception / Open House Copper-plate engraving of a "muscle man" from Andreas Vesalius (1514-1564). De humani corporis fabrica libri septem (Basel: Johannes Oporinus, 1543).
Bioethics Discussion: Antinatalism (December 10, 2019 7:00pm) https://events.umich.edu/event/52723 52723-12974156@events.umich.edu Event Begins: Tuesday, December 10, 2019 7:00pm
Location: Lurie Biomedical Engineering
Organized By: The Bioethics Discussion Group

A discussion on the end to our means.

Readings to consider:
1. The Last Messiah
2. Why It Is Better Never to Come into Existence
3. Every Conceivable Harm: A Further Defence of Anti-Natalism
4. The Ethics of Procreation and Adoption

For more information and/or to receive a copy of the readings contact Barry Belmont at belmont@umich.edu or visit http://belmont.bme.umich.edu/bioethics-discussion-group/discussions/037-antinatalism/.

Tell your descendants to consider the blog: https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Tue, 13 Aug 2019 10:54:42 -0400 2019-12-10T19:00:00-05:00 2019-12-10T20:30:00-05:00 Lurie Biomedical Engineering The Bioethics Discussion Group Lecture / Discussion Antinatalism
Professional Autobiography (December 10, 2019 7:00pm) https://events.umich.edu/event/70091 70091-17516173@events.umich.edu Event Begins: Tuesday, December 10, 2019 7:00pm
Location: Couzens Hall
Organized By: HSSP

Have you ever wondered how health care professionals end up in their careers? Professional Autobiographies are excellent opportunities for students to hear directly from health care professionals in an informal setting. During these talks, students will learn about speakers' motivations for their career choices, how their interests and experiences influenced their career trajectories, and how they’ve worked to align their passion(s) with their work. These sessions provide an excellent opportunity to connect with professionals who may be able to provide valuable advice during your Michigan career.

All HSSP-sponsored Professional Autobiographies are open to the public.

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Lecture / Discussion Sat, 07 Dec 2019 15:42:32 -0500 2019-12-10T19:00:00-05:00 2019-12-10T20:00:00-05:00 Couzens Hall HSSP Lecture / Discussion Andrea Siegel, Ph.D.
Learning Health Sciences Collaboratory Holiday Luncheon (December 12, 2019 12:00pm) https://events.umich.edu/event/69514 69514-17335463@events.umich.edu Event Begins: Thursday, December 12, 2019 12:00pm
Location: Michigan League
Organized By: Department of Learning Health Sciences

The Learning Health System (LHS) Collaboratory is a campus-wide hub for faculty, student and staff interest in LHS initiatives, advancing interdisciplinary research and promoting the development of learning health systems. To learn more about the Collaboratory, please visit: dlhs-umi.ch/lhs-collaboratory.

Join us on December 12th for our final event of 2019 as we get into the holiday spirit with the LHS Collaboratory! Enjoy food, friendship and some interesting updates at the LHS Collaboratory’s holiday luncheon and networking event. Feel free to bring a colleague (or two) who are new to the Collaboratory – the more the merrier! We welcome all members and their guests to celebrate the holiday season with the LHS Collaboratory! This will be an informal event with a short business meeting to bring everyone up to date on LHS developments across the country and around the world.

See you on the 12th!

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Lecture / Discussion Fri, 15 Nov 2019 13:34:25 -0500 2019-12-12T12:00:00-05:00 2019-12-12T13:30:00-05:00 Michigan League Department of Learning Health Sciences Lecture / Discussion Sign for Collaboratory
RNA Innovation Seminar, Silvie Rouskin, Whitehead/MIT (December 16, 2019 4:00pm) https://events.umich.edu/event/65144 65144-16541444@events.umich.edu Event Begins: Monday, December 16, 2019 4:00pm
Location: Palmer Commons
Organized By: Center for RNA Biomedicine

Silvie Rouskin, Ph.D., Andria and Paul Heafy Whitehead Fellow, Whitehead/MIT

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Lecture / Discussion Wed, 04 Dec 2019 11:08:39 -0500 2019-12-16T16:00:00-05:00 2019-12-16T17:00:00-05:00 Palmer Commons Center for RNA Biomedicine Lecture / Discussion flyer
Biosciences Initiative Second Annual Community Celebration and Symposium with President Schlissel (December 16, 2019 4:30pm) https://events.umich.edu/event/69140 69140-17252904@events.umich.edu Event Begins: Monday, December 16, 2019 4:30pm
Location: Michigan League
Organized By: Biosciences Initiative

Celebrating progress of the second year and introducing our 2019 Scientific Initiatives and Exploratory awardees.

The Biosciences Initiative is hosting its second annual community celebration, recognizing the progress of the second year and introducing its most recently awarded projects and groups.

Don't miss your opportunity to learn about these exciting proposals and connect with President Schlissel and fellow members of the biosciences community.

The Biosciences Initiative focuses on funding cutting-edge interdisciplinary research, expert faculty hires, and postgraduate education across the biological sciences at U-M.

Reception with free food and beverages will follow. RSVP to attend: https://docs.google.com/forms/d/e/1FAIpQLSeVAaOMh-bXpKiIfeMx5PQFEtjADiogJwEHlGkhVcfiiQGZ9w/viewform?usp=sf_link.

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Conference / Symposium Fri, 13 Dec 2019 12:30:00 -0500 2019-12-16T16:30:00-05:00 2019-12-16T18:30:00-05:00 Michigan League Biosciences Initiative Conference / Symposium bacteria and people graphic
BIONIC Lunch: Death Positivity (December 17, 2019 12:00pm) https://events.umich.edu/event/63779 63779-15873597@events.umich.edu Event Begins: Tuesday, December 17, 2019 12:00pm
Location: North Campus Research Complex Building 10
Organized By: The Bioethics Discussion Group

Join us for a lunchtime discussion in the mere hours we have remaining.

Please RSVP: https://forms.gle/HK2mP7nMLiB6L9w3A

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Lecture / Discussion Mon, 23 Sep 2019 14:01:00 -0400 2019-12-17T12:00:00-05:00 2019-12-17T13:30:00-05:00 North Campus Research Complex Building 10 The Bioethics Discussion Group Lecture / Discussion Death Positivity
Life Sciences Orchestra Concert (January 12, 2020 4:00pm) https://events.umich.edu/event/70590 70590-17609089@events.umich.edu Event Begins: Sunday, January 12, 2020 4:00pm
Location: Hill Auditorium
Organized By: Michigan Medicine

The U-M Life Sciences Orchestra will kick off its 20th season of blending music, medicine and science, with a free concert at 4 p.m. at U-M’s Hill Auditorium under the baton of music director Tal Benatar.

The concert is free and open to the public, as is a pre-concert lecture at 3:15 p.m. in the lower lobby. No tickets are required, though the LSO accepts donations to support its concerts.

The performance will begin with the overture to Fidelio, the only opera written by Ludwig van Beethoven, followed by the fairy tale-inspired Mother Goose Suite by Maurice Ravel. It will conclude with Finnish composer Jean Sibelius’s First Symphony.

The program offers a wide range of orchestral colors, highlighting the musical talents of the LSO’s members, nearly all of whom are medical, health and science faculty, staff, students, retirees and alumni from across the university.

Benatar is pursuing a doctorate, and assistant conductor Nathan Bieber a master’s degree, in the renowned orchestral conducting program at the U-M School of Music, Theatre & Dance.

Benatar holds the Gilbert S. Omenn, M.D. Music Director position with the LSO, made possible by a gift from its namesake, the first U-M executive vice president for medical affairs and a longtime supporter of the LSO. He is also Assistant Music Director of the Michigan Pops Orchestra, and a multi-instrument performer of classical, contemporary and popular music.

The orchestra is part of the Gifts of Art program, which brings the world of art and music to Michigan Medicine. Plans to celebrate the 20th anniversary at the LSO’s concert at 8 p.m. on Saturday, April 11 are now under way.

For information, visit http://lso.med.umich.edu/ or www.facebook.com/umlso, send e-mail to orchestra@umich.edu, or call (734) 936-ARTS.

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Performance Thu, 19 Dec 2019 10:58:32 -0500 2020-01-12T16:00:00-05:00 2020-01-12T18:00:00-05:00 Hill Auditorium Michigan Medicine Performance LSO concert January 2020
RNA Innovation Seminar, David Mathews, University of Rochester (January 13, 2020 4:00pm) https://events.umich.edu/event/65145 65145-16541445@events.umich.edu Event Begins: Monday, January 13, 2020 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

David Mathews , MD, PhD, Professor, Department of Biochemistry & Biophysics, University of Rochester

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Lecture / Discussion Tue, 17 Dec 2019 16:03:20 -0500 2020-01-13T16:00:00-05:00 2020-01-13T17:00:00-05:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion flyer
Genetic Privacy and Investigative Genetic Genealogy: Jan. 2020 Precision Health Seminar (January 14, 2020 12:00pm) https://events.umich.edu/event/65112 65112-16517527@events.umich.edu Event Begins: Tuesday, January 14, 2020 12:00pm
Location: Palmer Commons
Organized By: Precision Health

Summary:
In 2018, law enforcement identified a suspect in the Golden State Killer case by matching the genomic profile of DNA left at crime scenes to those held in genetic genealogy databases and by using inferred ancestral relationships and genealogical mapping to generate promising investigative leads. Since then, hundreds of cold cases have been solved using similar investigative strategies. Critics argue that investigative genetic genealogy violates the privacy of direct-to-consumer genetic testing customers and their genetic relatives, and some scholars worry that this will have a negative impact on data sharing in research and clinical care. During this session, we will explore the ethical, legal, and social implications of law enforcement access to DNA data collected and shared for non-forensic purposes and how best to balance competing interests in promoting public trust and protecting public safety.

About the seminar series:
The U-M Precision Health Seminar Series invites expert speakers to share meaningful, relevant, and late-breaking research on varied aspects of precision health. The interdisciplinary educational series, which takes place monthly during the academic year, features topics ranging from genetics to big data to health implementation (and much more) and is open to students, faculty, practitioners, staff, trainees, and the general public. Our goal is to increase understanding of precision health data, tools, and applications, to engage the academic community to enhance precision health research, and to support the implementation of precision health to health systems.

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Workshop / Seminar Thu, 05 Dec 2019 15:01:31 -0500 2020-01-14T12:00:00-05:00 2020-01-14T13:00:00-05:00 Palmer Commons Precision Health Workshop / Seminar Amy McGuire
DCMB Weekly Seminar (January 15, 2020 4:00pm) https://events.umich.edu/event/70964 70964-17760238@events.umich.edu Event Begins: Wednesday, January 15, 2020 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract: Synchronization occurs all around us. It underlies how fireflies flash as one, how human heart cells beat in unison, and how superconductors conduct electricity with no resistance. Synchronization is present in the precision of the cell cycle, and we can explore how breakdown of precision leads to disease. The many unique and fundamental functions of different cell types are achieved over and over independently, through a form of synchronization involving choreography of many proteins and genes. I will share a general historic and descriptive introduction to synchrony, including the classic work of Alan Turing. I will present some new work done jointly with Cleve Moler (MathWorks) and Steve Smale (UC Berkeley), where biology has inspired us to build new mathematical techniques to explore synchrony and its breakdown.

BlueJeans Livestream: https://primetime.bluejeans.com/a2m/live-event/rbuvycdc

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Lecture / Discussion Mon, 06 Jan 2020 15:39:08 -0500 2020-01-15T16:00:00-05:00 2020-01-15T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
"Catholic End of Life Ethics after Charlie Gard and Alfie Evans" (January 16, 2020 12:00pm) https://events.umich.edu/event/70258 70258-17556177@events.umich.edu Event Begins: Thursday, January 16, 2020 12:00pm
Location: Taubman Library
Organized By: The University of Michigan Medical School Program on Health, Spirituality and Religion

Dr. Michael Redinger, Assistant Professor of Psychiatry; Assistant Professor, Program in Medical Ethics, Humanities, and Law, Co-Chief, Program in Medical Ethics, Humanities, and Law, Western Michigan University

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Workshop / Seminar Thu, 12 Dec 2019 08:59:09 -0500 2020-01-16T12:00:00-05:00 2020-01-16T13:00:00-05:00 Taubman Library The University of Michigan Medical School Program on Health, Spirituality and Religion Workshop / Seminar
Taubman Tech Talk: DNA Methylation (January 16, 2020 5:00pm) https://events.umich.edu/event/71321 71321-17817081@events.umich.edu Event Begins: Thursday, January 16, 2020 5:00pm
Location:
Organized By: A. Alfred Taubman Medical Research Institute

pigenetic modifications are important drivers of development, health, and disease. DNA methylation is one type of epigenetic mark that can be measured in blood or other human samples. DNA methylation marks are associated with genetics and environmental exposures, which represents a useful tool for public health and medicine.

This presentation will give an overview of current technologies for DNA methylation measurements, describe methodological challenges associated with these methods, and provide evidence-based opportunities for future DNA methylation studies.

Kelly M. Bakulski, Ph.D. is an Assistant Professor in the Department of Epidemiology at the University of Michigan School of Public Health. Dr. Bakulski’s research goal is to understand the environmental and genetic etiologies of neurological disorders, including autism spectrum disorder and Alzheimer’s disease.

Dr. Bakulski incorporates population approaches and laboratory experiments to develop biomarker and cell type tools to better inform epigenetic inferences.

CME credit is available to physicians.

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Lecture / Discussion Mon, 13 Jan 2020 08:57:27 -0500 2020-01-16T17:00:00-05:00 2020-01-16T18:00:00-05:00 A. Alfred Taubman Medical Research Institute Lecture / Discussion Kelly Bakulski, PhD
Growth and Grit - Developing a Mindset For Success (January 22, 2020 5:30pm) https://events.umich.edu/event/70897 70897-17735191@events.umich.edu Event Begins: Wednesday, January 22, 2020 5:30pm
Location: Undergraduate Science Building
Organized By: Science Learning Center

What if your ability to succeed in your classes was determined in part before you even stepped into the classroom? What is the one quality you need to overcome adversity academically and in life? This workshop will detail the research of Dr. Carol Dweck and her groundbreaking work on the concept of mindset. Students will learn how to abandon a debilitating fixed mindset in favor of a growth mindset, leading to success in areas they once considered too difficult. The workshop will also introduce students to the research of Dr. Angela Duckworth, and how a growth mindset can lead to the development of grit, an essential characteristic to overcoming our fear of failure.

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Workshop / Seminar Wed, 15 Jan 2020 10:16:28 -0500 2020-01-22T17:30:00-05:00 2020-01-22T19:00:00-05:00 Undergraduate Science Building Science Learning Center Workshop / Seminar
Twitter Chat: How to organize transgender health services (January 23, 2020 7:00pm) https://events.umich.edu/event/71498 71498-17834211@events.umich.edu Event Begins: Thursday, January 23, 2020 7:00pm
Location: Off Campus Location
Organized By: Annals of Family Medicine

Are you interested in health care access for trans and gender diverse folks? Join our online Twitter chat with clinicians and health educators from Fenway Health, Harvard Medical School, and the National LGBT Health Education Center at The Fenway Institute on Thursday, January 23, 2020, from 7 to 8PM EST on Twitter using the hashtag #AnnalsChat.

The chat is hosted by the U-M Medical School-based peer reviewed research journal, the Annals of Family Medicine. http://www.annfammed.org/. Our invited guests published this free, open access blueprint for planning and implementing a transgender health program: http://www.annfammed.org/content/18/1/73

To join the conversation on Thursday, follow the Annals on Twitter @annfammed: https://twitter.com/annfammed.

You can follow along with the discussion by searching for the hashtag #AnnalsChat on Twitter. Another way to participate in the chat is to use this app that allows you to pause the chat if the Tweets are coming at you too fast: http://www.tchat.io/ (Search for #AnnalsChat).

For more questions, contact Noa Kim at annfammed@umich.edu.

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Lecture / Discussion Wed, 15 Jan 2020 11:05:42 -0500 2020-01-23T19:00:00-05:00 2020-01-23T20:00:00-05:00 Off Campus Location Annals of Family Medicine Lecture / Discussion a transgender pride flag with the background of architectural blueprints
Privacy@Michigan 2020 (January 28, 2020 1:00pm) https://events.umich.edu/event/71094 71094-17777056@events.umich.edu Event Begins: Tuesday, January 28, 2020 1:00pm
Location: Rackham Graduate School (Horace H.)
Organized By: Information and Technology Services (ITS)

Register to attend the Privacy@Michigan Symposium and Research Showcase Tuesday, January 28, 1 p.m. – 6:00 p.m. in the Rackham Amphitheatre (4th floor) and celebrate the 2020 International Data Privacy Day. Attendance is free and open to the public but space is limited. Please RSVP.

For a schedule of events and to register visit: https://safecomputing.umich.edu/events/privacy-at-michigan/2020

Kathleen Kingsbury, editor of The New York Times Privacy Project, will give the keynote address. Multi-disciplinary experts will participate in panel discussions on a range of privacy-related topics. A privacy fair including a privacy clinic, where students help with general privacy questions, and posters showcasing privacy research at the University of Michigan will be available throughout the afternoon.

This event organized by the University of Michigan School of Information, University of Michigan Information Assurance, and the Dissonance Event Series.

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Conference / Symposium Fri, 10 Jan 2020 13:49:19 -0500 2020-01-28T13:00:00-05:00 2020-01-28T18:30:00-05:00 Rackham Graduate School (Horace H.) Information and Technology Services (ITS) Conference / Symposium Privacy@Michigan Symposium - Keynote Speaker: Kathleen Kingsbury
DCMB Seminar Series (January 29, 2020 4:00pm) https://events.umich.edu/event/71998 71998-17911963@events.umich.edu Event Begins: Wednesday, January 29, 2020 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Talk Title: Experimental and computational strategies to aid compound identification and quantitation in metabolomics

Abstract: Over the past two decades, metabolomics as a technique has moved from the primary domain of analytical chemists to more widespread acceptance by biologists, clinicians and bioinformaticians alike. Metabolomics offers systems-level insights into the critical roles small molecules play in routine cellular processes and myriad disease states. However, certain unique analytical challenges remain prominent in metabolomics as compared to the other ‘omics sciences. These include the difficulty of identifying unknown features in untargeted metabolomics data, and challenges maintaining reliable quantitation within lengthy studies that may span multiple laboratories. Unlike genomics and transcriptomics data in which nearly every quantifiable feature is confidently identified as a matter of course, in typical untargeted metabolomics studies over 80% of features are frequently not mapped to a specific chemical compound. Further, although many metabolomics studies have begun to stretch over a timeframe of years, data quantitation and normalization strategies have not always kept up with the requirements for such large studies. Fortunately, both experimental and computational strategies are emerging to tackle these long-standing challenges. We will report on several techniques in development in our laboratory, ranging from chromatographic fractionation and high-sensitivity data acquisition, to computational strategies to aid in tandem mass spectrometric spectral interpretation. These developments serve to facilitate analysis for both experts and novice users, which should ultimately help improve the biological insight and impact gained from metabolomics data.

BlueJeans livestreaming link: https://primetime.bluejeans.com/a2m/live-event/rbuvycdc

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Lecture / Discussion Fri, 24 Jan 2020 11:07:13 -0500 2020-01-29T16:00:00-05:00 2020-01-29T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
Honors Medical School application workshop (January 29, 2020 4:00pm) https://events.umich.edu/event/71046 71046-17768658@events.umich.edu Event Begins: Wednesday, January 29, 2020 4:00pm
Location: Mason Hall
Organized By: LSA Honors Program

Are you planning on applying to medical school this summer and want help in this process? If so, we invite you to attend this Honors Program workshop led by Stephanie Chervin, LSA Honors Program Pre-Med Advisor, to help you:

• Understand the timeline of the process from application to interview

• Choose target medical programs

• Get acquainted with the application service AMCAS

Bring your questions! This session is for current LSA Honors Program students only.

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Workshop / Seminar Tue, 07 Jan 2020 16:11:50 -0500 2020-01-29T16:00:00-05:00 2020-01-29T17:15:00-05:00 Mason Hall LSA Honors Program Workshop / Seminar Model organ
Make It Stick - Research-Based Learning Strategies You Need to Know (January 29, 2020 5:30pm) https://events.umich.edu/event/70899 70899-17735192@events.umich.edu Event Begins: Wednesday, January 29, 2020 5:30pm
Location: Undergraduate Science Building
Organized By: Science Learning Center

The study and learning strategies students often bring to college are often insufficient to help them succeed at the university level. Particularly in challenging STEM courses, students can't simply memorize or cram their way to a good grade. This workshop will focus on the popular learning strategies to avoid, as well as the top three strategies you don't know but are shown by research to be the most effective for long-term learning.

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Workshop / Seminar Wed, 15 Jan 2020 10:18:11 -0500 2020-01-29T17:30:00-05:00 2020-01-29T19:00:00-05:00 Undergraduate Science Building Science Learning Center Workshop / Seminar make it stick by Brown, Roediger III, and McDaniel
LHS Collaboratory: Applications of AI/Machine Learning in Gastroenterology (January 29, 2020 7:00pm) https://events.umich.edu/event/71218 71218-17959605@events.umich.edu Event Begins: Wednesday, January 29, 2020 7:00pm
Location:
Organized By: Department of Learning Health Sciences

Dr. Waljee’s research focuses on tailoring treatment to the specifics of the individual (precision care) with gastrointestinal and liver diseases. He uses artificial intelligence methods such as machine learning and deep learning to improve decision-making for tailored and individualized care to facilitate the delivery of efficient, effective and equitable care, especially in costly diseases and in limited resource settings.
Discussant 1: Karandeep Singh, MD, MMSc, Assistant Professor, University of Michigan Department of Learning Health Sciences and Department of Internal Medicine

Discussant 2: Kayte Spector-Bagdady, JD, MBioethics, Assistant Professor, University of Michigan Department of Obstetrics and Gynecology and Chief of the Research Ethics Service in the Center for Bioethics and Social Sciences in Medicine.

Please register in advance, *dlhs-umi.ch/lhs-collaboratory.*

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Lecture / Discussion Wed, 29 Jan 2020 19:36:03 -0500 2020-01-29T19:00:00-05:00 2020-01-29T20:00:00-05:00 Department of Learning Health Sciences Lecture / Discussion LHS Collaboratory
Non-Pharmacological Approaches to Memory Loss (January 30, 2020 10:00am) https://events.umich.edu/event/69818 69818-17431807@events.umich.edu Event Begins: Thursday, January 30, 2020 10:00am
Location: Detroit Center
Organized By: Michigan Alzheimer's Disease Center

Benjamin Hampstead, PhD of the University of
Michigan will present: "Non-Pharmacological
Approaches to Memory Loss." Dr. Hampstead is an
Associate Professor of Psychiatry at the University of
Michigan and Clinical Core Leader of the Michigan
Alzheimer's Disease Research Center.

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Presentation Fri, 13 Dec 2019 09:36:23 -0500 2020-01-30T10:00:00-05:00 2020-01-30T12:00:00-05:00 Detroit Center Michigan Alzheimer's Disease Center Presentation
LHS Collaboratory: Applications of AI/Machine Learning in Gastroenterology (January 30, 2020 12:00pm) https://events.umich.edu/event/71218 71218-17787742@events.umich.edu Event Begins: Thursday, January 30, 2020 12:00pm
Location: Michigan Union
Organized By: Department of Learning Health Sciences

Dr. Waljee’s research focuses on tailoring treatment to the specifics of the individual (precision care) with gastrointestinal and liver diseases. He uses artificial intelligence methods such as machine learning and deep learning to improve decision-making for tailored and individualized care to facilitate the delivery of efficient, effective and equitable care, especially in costly diseases and in limited resource settings.
Discussant 1: Karandeep Singh, MD, MMSc, Assistant Professor, University of Michigan Department of Learning Health Sciences and Department of Internal Medicine

Discussant 2: Kayte Spector-Bagdady, JD, MBioethics, Assistant Professor, University of Michigan Department of Obstetrics and Gynecology and Chief of the Research Ethics Service in the Center for Bioethics and Social Sciences in Medicine.

Please register in advance, *dlhs-umi.ch/lhs-collaboratory.*

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Lecture / Discussion Wed, 29 Jan 2020 19:36:03 -0500 2020-01-30T12:00:00-05:00 2020-01-30T13:30:00-05:00 Michigan Union Department of Learning Health Sciences Lecture / Discussion LHS Collaboratory
NERS Colloquium: Medical Imaging Advances: Do All Bell-and-Whistle Options Impact Patient Care? (January 31, 2020 4:00pm) https://events.umich.edu/event/70139 70139-17540914@events.umich.edu Event Begins: Friday, January 31, 2020 4:00pm
Location: Cooley Building
Organized By: Nuclear Engineering and Radiological Sciences

Learn about the development of Computed Tomography from its inception in the early 1970s to the present; the medical applications of CT (e.g., diagnostic radiology, radiation oncology, and interventional CBCT); and the current state of how CT improvements are driven. The theme of the discussion will be to highlight the key technological advances that increased the value of CT in medicine. Examples of advancements with unquestionable benefit to patient care and other “advancements” with motivation rooted in unwarranted fear over radiation dose will be covered. This discussion will be presented in a manner suitable for the non-medical imaging expert to convey the larger themes related to technology advancement in the space of medical imaging.


Speaker: Timothy Szczykutowicz, University of Wisconsin School of Medicine and Public Health, Department of Medical Physics

Dr. Szczykutowicz is an assistant professor in the University of Wisconsin School of Medicine and Public Health Departments of Radiology, Medical Physics, and Biomedical Engineering. He received his Bachelors of Science in Physics from the SUNY University at Buffalo in 2008. He was active in medical physics at Buffalo in the laboratory of Dr. Stephen Rudin with the Toshiba Stroke Research Center, working on vessel sizing and detector performance characterization. After his undergraduate studies, Dr. Szczykutowicz came to the University of Wisconsin–Madison where he earned his Masters and PhD in Medical Physics, receiving mentorship from Doctors Charles 'Chuck' Mistretta and Guang-Hong Chen. His dissertation was on fluence field modulated CT, a promising x-ray imaging technique that allows for imaging dose to be tailored to individuals. After his dissertation work, Dr. Szczykutowicz spent a year as a doctrinal fellow and imaging physics resident with the Department of Medical Physics at the UW before being appointed as a clinical health sciences Assistant Professor. The clinical and research activities of Dr. Szczykutowicz include: optimizing CT scan protocols, monitoring patient dose, developing new metrics to define image quality in the clinical setting, developing protocol management methodologies, fluence field modulated CT, dual energy CT, and assisting in various projects related to cone beam CT.

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Workshop / Seminar Tue, 14 Jan 2020 13:45:32 -0500 2020-01-31T16:00:00-05:00 2020-01-31T17:00:00-05:00 Cooley Building Nuclear Engineering and Radiological Sciences Workshop / Seminar Speaker: Timothy Szczykutowicz
BME Student Speaker: Xiaotian Tan (February 3, 2020 12:00pm) https://events.umich.edu/event/72234 72234-17963872@events.umich.edu Event Begins: Monday, February 3, 2020 12:00pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: Biomedical Engineering

Biosensors are devices or systems that can be used to detect, quantify, and analyze targets with biological activities and functions. As one of the largest subsets of biosensors, biomolecular sensors are specifically developed and programmed to detect, quantify and analyze biomolecules in liquid samples. Wide-ranging applications have made immunoassays increasingly popular for biomolecular detection and quantification. Among these, enzyme-linked immunosorbent assays (ELISA) are of particular interest due to high specificity and reproducibility. To some extent, ELISA has been regarded as a “gold standard” for quantifying analytes (especially protein analytes) in both clinical diagnostics and fundamental biological research. However, traditional (96-well plate-based) ELISA still suffers from several notable drawbacks, such as long assay time (4–6 hours), lengthy procedures, and large sample/reagent consumption (∼100 μL). These inherent disadvantages still significantly limit traditional ELISA's applicability to areas such as rapid clinical diagnosis of acute diseases (e.g., viral pneumonia, acute organ rejection), and biological research that requires accurate measurements with precious or low abundance samples (e.g., tail vein serum from a mouse). Thus, a bimolecular sensing technology that has high sensitivity, short assay time, and small sample/reagent consumption is still strongly desired. In this dissertation, we introduce the development of a multifunctional and automated optofluidic biosensing platform that can resolve the aforementioned problems. In contrast to conventional plate-based ELISA, our optofluidic ELISA platform utilizes mass-producible polystyrene microfluidic channels with a high surface-to-volume ratio as the immunoassay reactors, which greatly shortens the total assay time. We also developed a low-noise signal amplification protocol and an optical signal quantification system that was optimized for the optofluidic ELISA platform. Our optofluidic ELISA platform provides several attractive features such as small sample/reagent consumption (<8 μL), short total assay time (30-45 min), high sensitivity (~1 pg/mL for most markers), and a broad dynamic range (3-4 orders of magnitude). Using these features, we successfully quantified mouse FSH (follicle stimulating hormone) concentration with a single drop of tail vein serum. We also successfully monitored bladder cancer progression in orthotopic xenografted mice with only <50 μL of mouse urine. More excitingly, we achieved highly-sensitive exosome quantification and multiplexed immuno-profiling with <40 ng/mL of total input protein (per assay). These remarkable milestones could not be achieved with conventional plate-based ELISA but were enabled by our unique optofluidic ELISA.

As an emerging member of the bimolecular sensor family, our optofluidic ELISA platform provides a high-performance and cost-effective tool for a plethora of applications, including endocrinal, cancer animal model, cellular biology, and even forensic science research. In the future, this technology platform can also be renovated for clinical applications such as personalized cancer diagnosis/prognosis and rapid point-of-care diagnostics for infectious diseases.

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Lecture / Discussion Thu, 30 Jan 2020 09:19:52 -0500 2020-02-03T12:00:00-05:00 2020-02-03T13:00:00-05:00 Lurie Biomedical Engineering (formerly ATL) Biomedical Engineering Lecture / Discussion Xiaotian Tan
Science as Art Contest Submission Deadline (February 5, 2020 11:55am) https://events.umich.edu/event/48786 48786-17963888@events.umich.edu Event Begins: Wednesday, February 5, 2020 11:55am
Location: Hatcher Graduate Library
Organized By: Arts at Michigan

Arts at Michigan, ArtsEngine and the Science Learning Center invite you to submit artwork to the 2020 Science as Art exhibition. University of Michigan undergraduate students are invited to submit artwork expressing a scientific principle(s), concept(s), idea(s), process(es), and/or structure(s). The artwork may be visual, literary, musical, video, or performance based. A juried panel using criteria based on both scientific and artistic considerations will choose winning submissions.

Deadline for submissions is Wednesday February 5th!

A number of submissions will be selected for prizes, some of which will be on display and/or performed during the Awards Ceremony and/or displayed in an online Contest Gallery. The entry selected for “Best Overall” will be awarded a cash prize, with smaller cash awards in other categories.

For full information, visit: tinyurl.com/scienceasart2020

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Exhibition Thu, 30 Jan 2020 11:47:29 -0500 2020-02-05T11:55:00-05:00 2020-02-05T23:59:00-05:00 Hatcher Graduate Library Arts at Michigan Exhibition Science as Art logo
Startup Career Fair (February 7, 2020 12:00pm) https://events.umich.edu/event/72206 72206-17957291@events.umich.edu Event Begins: Friday, February 7, 2020 12:00pm
Location: Duderstadt Center
Organized By: MPowered Entrepreneurship

Startup Career Fair provides students with the opportunity to pursue their passion and get paid for it. From Productiv in San Francisco to Choco from Berlin, world-renowned startups with mission-driven teams are waiting to hire you.

We invite you to join us on February 7 from 12-4pm at the Duderstadt Center on North Campus. Register by February 4th and you'll be entered into a lottery for an invitation to our exclusive networking breakfast with recruiters. Can’t wait to see you #Launch.

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Careers / Jobs Wed, 29 Jan 2020 13:06:39 -0500 2020-02-07T12:00:00-05:00 2020-02-07T16:00:00-05:00 Duderstadt Center MPowered Entrepreneurship Careers / Jobs #Launch
E-Hour Speaker Series: Samir Kaul (February 7, 2020 12:30pm) https://events.umich.edu/event/72245 72245-17963884@events.umich.edu Event Begins: Friday, February 7, 2020 12:30pm
Location: Walgreen Drama Center
Organized By: Center for Entrepreneurship

The weekly Entrepreneurship Hour speaker series is back every Friday during the academic year, free and open to the public to attend.

Samir is a Founding Partner and Managing Director at Khosla Ventures, where he focuses on health, sustainability, food, and advanced technology investments. Samir led the firm’s investments in Editas Medicine, EtaGen, Guardant Health, Impossible Foods, Nutanix, Oscar, Pymetrics, and View, among others.

Previously, Samir was at Flagship Ventures where he founded and invested in early-stage biotechnology companies, and Craig Venter’s Institute for Genomic Research where he led the Arabidopsis Genome Initiative. He is active in philanthropy and has been a longstanding member of the leadership committee of the Tipping Point Community and a board member of UCSF Benioff Children’s Hospital.

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Presentation Thu, 30 Jan 2020 11:00:50 -0500 2020-02-07T12:30:00-05:00 2020-02-07T13:30:00-05:00 Walgreen Drama Center Center for Entrepreneurship Presentation Samir Kaul
Public Health Outcomes and Effects of the Built Environment: Feb. 2020 Precision Health Seminar (February 11, 2020 12:00pm) https://events.umich.edu/event/65113 65113-16517528@events.umich.edu Event Begins: Tuesday, February 11, 2020 12:00pm
Location: Palmer Commons
Organized By: Precision Health

Public Health Outcomes and Effects of the Built Environment: A Look at PHOEBE Laboratory Research

The mission of the Public Health Outcomes and Effects of the Built Environment (PHOEBE) Laboratory is to gain an improved understanding of how our built environments--or rather the man-made places and spaces of our neighborhoods and communities, such as buildings, parks, and transportation systems--can impact the health and well-being of individuals of all ages. This presentation will describe some of the research that has been conducted within the PHOEBE Laboratory, including the BEAP (Built Environment and Active Play), PEAT (Physical Environment and Active Transportation), and PLIGHT (Purple Line Impact on Neighborhood, Health and Transit) Studies. Highlights and findings from the BEAP and PEAT Studies on youth physical activity, sedentary behavior, and active transportation will be discussed. In addition, an introductory overview of the PLIGHT Study, a natural experiment examining the health impacts of the forthcoming Purple Line light rail line in the Washington, DC, metropolitan area, will be presented.

Lunch will be provided for those who register by February 7.

Bio:
Jennifer D. Roberts is an Assistant Professor of Kinesiology at the University of Maryland School of Public Health. She is also the Director of the Public Health Outcomes and Effects of the Built Environment (PHOEBE) Laboratory. Her research interests focus on the relationship between the built environment and physical activity in addition to its impact on obesity and other public health outcomes. More specifically, much of her research has explored the dynamic relationship between environmental, social and cultural determinants of physical activity and using empirical evidence of this relationship to infer complex health outcome patterns and disparities among adults and children.

PHOEBE Laboratory research, such as the Built Environment and Active Play (BEAP) and Physical Environment and Active Transportation (PEAT) Studies, have incorporated state of the art techniques including spatial analysis and geographic information system modeling in order to objectively capture the role and relationship of physical activity determinants. While relying heavily on mixed methodology, crosscutting health issues, along with exposure (e.g., transit deserts) and outcome (e.g., obesity) disparities, have also been addressed in her physical activity and public health research program. Dr. Roberts currently leads the Purple Line Light Rail Impact on Neighborhood, Health and Transit (PLIGHT) Study, to investigate changes in light rail use, active transportation, overall physical activity, obesity, and obesity-related cardiovascular risks among Prince George’s County, Maryland, adults. The PLIGHT Study will also explore how contextual effects (e.g., built environment; “sense of community”) moderate these health outcome changes with the intended 2022 introduction of this new 16.2-mile light rail line.

Dr. Roberts was awarded a JPB Environmental Health Fellowship by Harvard University’s T.H. Chan School of Public Health. This three-year fellowship will support her forthcoming research, Gauging Effects of Neighborhood Trends and Sickness (GENTS) Study: Examining the Perception of Transit-Induced Gentrification in Prince George’s County. GENTS will examine the risk of transit-induced gentrification and the associated health effects (e.g., anxiety) as related to the aforementioned Purple Line light rail. While the introduction of light rail in communities often encourages physical activity by way of active transportation, gentrification is often an unintended consequence and socioeconomic by-product of transit-oriented development.

Dr. Roberts received her Bachelor of Arts (AB) degree from Brown University. She holds a Master of Public Health (MPH) degree from Emory University Rollins School of Public Health and earned her Doctor of Public Health (DrPH) degree from Johns Hopkins University Bloomberg School of Public Health.



The U-M Precision Health Seminar Series invites expert speakers to share meaningful, relevant, and late-breaking research on varied aspects of precision health. The interdisciplinary educational series, which takes place monthly during the academic year, features topics ranging from genetics to big data to health implementation (and much more) and is open to students, faculty, practitioners, staff, trainees, and the general public. Our goal is to increase understanding of precision health data, tools, and applications, to engage the academic community to enhance precision health research, and to support the implementation of precision health to health systems.

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Workshop / Seminar Wed, 08 Jan 2020 11:32:03 -0500 2020-02-11T12:00:00-05:00 2020-02-11T13:00:00-05:00 Palmer Commons Precision Health Workshop / Seminar Jennifer D. Roberts
Bioethics Discussion: Love (February 11, 2020 7:00pm) https://events.umich.edu/event/52726 52726-12974160@events.umich.edu Event Begins: Tuesday, February 11, 2020 7:00pm
Location: Lurie Biomedical Engineering
Organized By: The Bioethics Discussion Group

A discussion on the chemistry of our biology.

Readings to consider:
1. The Neurobiology of Love
2. The Medicalization of Love
3. Self-Transcendence, the True Self, and Self-Love
4. Love yourself: The relationship of the self with itself in popular self-help texts

For more information and/or to receive a copy of the readings contact Barry Belmont at belmont@umich.edu or visit http://belmont.bme.umich.edu/bioethics-discussion-group/discussions/040-love/.

You might love the blog: https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Thu, 09 Jan 2020 09:56:11 -0500 2020-02-11T19:00:00-05:00 2020-02-11T20:30:00-05:00 Lurie Biomedical Engineering The Bioethics Discussion Group Lecture / Discussion Love
Chaat Night With Project RISHI (February 11, 2020 8:30pm) https://events.umich.edu/event/72546 72546-18037798@events.umich.edu Event Begins: Tuesday, February 11, 2020 8:30pm
Location: Mason Hall
Organized By: Project RISHI

Come join Project RISHI as we admire Indian cuisine in the form of CHAAT! Chaat is a famous street food dish that is served all around India. The money from this fundraiser will go towards social impact and helping rural villages. This event will take place on Tuesday February 11th from 8:30- 9:30pm at 3353 Mason Hall. The entrance fee will be $3! All are welcome to join!

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Social / Informal Gathering Fri, 07 Feb 2020 18:42:18 -0500 2020-02-11T20:30:00-05:00 2020-02-11T21:30:00-05:00 Mason Hall Project RISHI Social / Informal Gathering Come join Project RISHI at their Chaat night on Tuesday February 11th from 8:30- 9:30pm at 3353 Mason Hall!
BME Ph.D Defense: Xiaotian Tan (February 12, 2020 11:00am) https://events.umich.edu/event/72235 72235-17963874@events.umich.edu Event Begins: Wednesday, February 12, 2020 11:00am
Location: Cooley Building
Organized By: Biomedical Engineering

Biosensors are devices or systems that can be used to detect, quantify, and analyze targets with biological activities and functions. As one of the largest subsets of biosensors, biomolecular sensors are specifically developed and programmed to detect, quantify and analyze biomolecules in liquid samples.

Wide-ranging applications have made immunoassays increasingly popular for biomolecular detection and quantification. Among these, enzyme-linked immunosorbent assays (ELISA) are of particular interest due to high specificity and reproducibility. To some extent, ELISA has been regarded as a “gold standard” for quantifying analytes (especially protein analytes) in both clinical diagnostics and fundamental biological research. However, traditional (96-well plate-based) ELISA still suffers from several notable drawbacks, such as long assay time (4–6 hours), lengthy procedures, and large sample/reagent consumption (∼100 μL). These inherent disadvantages still significantly limit traditional ELISA's applicability to areas such as rapid clinical diagnosis of acute diseases (e.g., viral pneumonia, acute organ rejection), and biological research that requires accurate measurements with precious or low abundance samples (e.g., tail vein serum from a mouse). Thus, a bimolecular sensing technology that has high sensitivity, short assay time, and small sample/reagent consumption is still strongly desired.

In this dissertation, we introduce the development of a multifunctional and automated optofluidic biosensing platform that can resolve the aforementioned problems. In contrast to conventional plate-based ELISA, our optofluidic ELISA platform utilizes mass-producible polystyrene microfluidic channels with a high surface-to-volume ratio as the immunoassay reactors, which greatly shortens the total assay time. We also developed a low-noise signal amplification protocol and an optical signal quantification system that was optimized for the optofluidic ELISA platform.

Our optofluidic ELISA platform provides several attractive features such as small sample/reagent consumption (<8 µL), short total assay time (30-45 min), high sensitivity (~1 pg/mL for most markers), and a broad dynamic range (3-4 orders of magnitude). Using these features, we successfully quantified mouse FSH (follicle stimulating hormone) concentration with a single drop of tail vein serum. We also successfully monitored bladder cancer progression in orthotopic xenografted mice with only <50 µL of mouse urine. More excitingly, we achieved highly-sensitive exosome quantification and multiplexed immuno-profiling with <40 ng/mL of total input protein (per assay). These remarkable milestones could not be achieved with conventional plate-based ELISA but were enabled by our unique optofluidic ELISA.

As an emerging member of the bimolecular sensor family, our optofluidic ELISA platform provides a high-performance and cost-effective tool for a plethora of applications, including endocrinal, cancer animal model, cellular biology, and even forensic science research. In the future, this technology platform can also be renovated for clinical applications such as personalized cancer diagnosis/prognosis and rapid point-of-care diagnostics for infectious diseases.

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Lecture / Discussion Thu, 30 Jan 2020 09:28:04 -0500 2020-02-12T11:00:00-05:00 2020-02-12T12:00:00-05:00 Cooley Building Biomedical Engineering Lecture / Discussion Xiaotian Tan
Department of Computational Medicine & Bioinformatics (DCMB) Weekly Seminar (February 12, 2020 4:00pm) https://events.umich.edu/event/72535 72535-18015945@events.umich.edu Event Begins: Wednesday, February 12, 2020 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract:
Normal mechanical function of the heart requires that ATP be continuously synthesized at a hydrolysis potential of roughly -60 kJ mol-1. Yet in both the aging and diseased heart the relationships between cardiac work rate and concentrations of ATP, ADP, and inorganic phosphate are altered. Important outstanding questions are: To what extent do changes in metabolite concentrations that occur in aging and heart disease affect metabolic/molecular processes in the myocardium? How are systolic and diastolic functions affected by changes in metabolite concentrations? Does metabolic energy supply represent a limiting factor in determining physiological maximal cardiac power output and exercise capacity? Does the derangement of cardiac energetics that occurs with heart failure cause exercise intolerance?

To answer these questions, we have developed a multi-physics multi-scale model of cardiac energy metabolism and cardiac mechanics that simulates the dependence of myocardial ATP demand on muscle dynamics and the dependence of muscle dynamics on cardiac energetics. Model simulations predict that the maximal rate at which ATP can be synthesized at free energies necessary to drive physiological mechanical function determine maximal heart rate, cardiac output, and cardiac power output in exercise. Furthermore, we find that reductions in cytoplasmic adenine nucleotide, creatine, and phosphate pools that occur with aging impair the myocardial capacity to synthesize ATP at physiological free energy levels, and that the resulting changes to myocardial energetic status play a causal role in contributing to reductions in maximal cardiac power output with aging. Finally, model predictions reveal that reductions in cytoplasmic metabolite pools contribute to energetic dysfunction in heart failure, which in turn contributes to causing systolic dysfunction in heart failure.

BlueJeans Livestream Link: https://primetime.bluejeans.com/a2m/live-event/rbuvycdc

3:45 p.m. - Light Refreshments served in Forum Hall Atrium
4:00 p.m. - Lecture in Forum Hall

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Lecture / Discussion Wed, 05 Feb 2020 08:41:29 -0500 2020-02-12T16:00:00-05:00 2020-02-12T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
A Concert for HOPE (February 12, 2020 7:00pm) https://events.umich.edu/event/71771 71771-17879422@events.umich.edu Event Begins: Wednesday, February 12, 2020 7:00pm
Location: Hill Auditorium
Organized By: Michigan Medicine Department of Surgery

Join us along with the Mosaic Youth Theatre of Detroit, Adam Foss, JD, and others for a free event at Hill Auditorium on February 12, 2020 to build awareness and support for the HOPE Collaborative at Michigan Medicine.

The HOPE (health equity, opportunity, pipeline, and education) Collaborative’s goals are threefold: develop, strengthen, and study early pipeline and youth educational programs for medicine; broaden Michigan Medicine’s clinical reach and engagement of community partners for at-risk neighborhoods; diversify training programs and trainee recruitment.

Our guest performers and speakers will inspire and build excitement around the opportunities for underrepresented minorities in medicine.

Mosaic Youth Theatre of Detroit is an award-winning national model for Creative Youth Development. Founded in 1992,Mosaic annually provides accessible acting and singing training for hundreds of youth from more than 50 Metro Detroit schools. Mosaic's mission is to empower young people to maximize their potential through professional performing arts training and the creation of theatrical and musical art that engages, transforms and inspires. The organization has toured their critically-acclaimed all-teen performances to Europe, Asia, Africa, 25 states throughout the U.S., the White House and The Kennedy Center. At the 2014 World Choir Games in Latvia, Mosaic brought home two gold and two silver medals. Mosaic is proud to report that 95% of their performers have gone on to college. To learn more about Mosaic Youth Theatre of Detroit, visit us online at www.mosaicdetroit.org.

Adam Foss, JD, is a renowned prosecutor and criminal-justice reform advocate who founded Prosecutor Impact – a non-profit focused on training prosecutors to reframe their role in the criminal justice system to focus on metrics beyond “cases won.”

This event is free, but there will be opportunities to support the mission through donations. Funds will be directed towards resources supporting the HOPE Collaborative’s mission.

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Performance Mon, 20 Jan 2020 14:45:40 -0500 2020-02-12T19:00:00-05:00 2020-02-12T21:00:00-05:00 Hill Auditorium Michigan Medicine Department of Surgery Performance Impacting HOPE Collaborative
BME 500: Leyuan Ma, Ph.D. (February 13, 2020 4:00pm) https://events.umich.edu/event/70420 70420-17594472@events.umich.edu Event Begins: Thursday, February 13, 2020 4:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Chimeric antigen receptor (CAR) T-cell therapy has shown dramatic clinical responses in hematologic malignancies, with a high proportion of durable complete remissions elicited in leukemia and lymphomas. However, achieving the full promise of CAR T-cell therapy, especially in solid tumors, will require further advances in this form of cellular therapy. A key challenge is maintaining a sufficient pool of functional CAR T cells in vivo. We recently developed a strategy to target vaccines to lymph nodes, by linking peptide antigens to albumin-binding phospholipid-polymers. Constitutive trafficking of albumin from blood to lymph makes it ideal chaperone to concentrate these “amphiphile-vaccine” molecules in lymph nodes that would otherwise be rapidly dispersed in the bloodstream following parenteral injection. These lipid-polymer conjugates also exhibit the property that they insert in cell membranes on arrival in lymph nodes. Here, we generated amphiphile CAR T ligand (amph-ligand) vaccine by exploiting these dual lymph node targeting and membrane-decorating properties to repeatedly expand and rejuvenate CAR T cells through the chimeric receptor in native lymph node microenvironment. We evaluated this approach in the presence of a complete host immune system. Amph-ligand vaccine boosting triggered massive CAR T expansion, increased donor cell polyfunctionality, and enhanced anti-tumor efficacy in multiple immunocompetent tumor models. We demonstrate two approaches to generalize this strategy to any CAR, enabling this simple HLA-independent vaccination approach to enhance CAR T functionality to be applied to existing CAR T cell designs. Taken together, our amph-ligand vaccine provides a simple engineering solution to augment CAR T-cell therapy.

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Lecture / Discussion Fri, 07 Feb 2020 13:11:56 -0500 2020-02-13T16:00:00-05:00 2020-02-13T17:00:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Lecture / Discussion BME Logo
Honors Medical School application workshop (February 13, 2020 4:00pm) https://events.umich.edu/event/71048 71048-17768660@events.umich.edu Event Begins: Thursday, February 13, 2020 4:00pm
Location: Mason Hall
Organized By: LSA Honors Program

Are you planning on applying to medical school this summer and want help in this process? If so, we invite you to attend this Honors Program workshop led by Stephanie Chervin, LSA Honors Program Pre-Med Advisor, to help you:

• Understand the timeline of the process from application to interview

• Choose target medical programs

• Get acquainted with the application service AMCAS

Bring your questions! This session is for current LSA Honors Program students only.

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Workshop / Seminar Tue, 07 Jan 2020 16:15:07 -0500 2020-02-13T16:00:00-05:00 2020-02-13T17:15:00-05:00 Mason Hall LSA Honors Program Workshop / Seminar Doctor with a stethoscope
Ace Your Courses: Metacognition is Key! (February 13, 2020 5:00pm) https://events.umich.edu/event/70903 70903-17735208@events.umich.edu Event Begins: Thursday, February 13, 2020 5:00pm
Location: Undergraduate Science Building
Organized By: Science Learning Center

Have you ever found yourself putting forth a great deal of effort into your courses, but not feeling like you are actually learning or are left unsatisfied with your grade? This workshop, based on the work of Dr. Saundra Yancy McGuire, will enable you to analyze your current learning strategies, understand exactly what changes you need to implement to earn an A in your courses, identify concrete strategies to use during the remainder of your semester, and become a more efficient learner.

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Workshop / Seminar Wed, 15 Jan 2020 10:19:28 -0500 2020-02-13T17:00:00-05:00 2020-02-13T18:30:00-05:00 Undergraduate Science Building Science Learning Center Workshop / Seminar Teach Yourself How to Learn by Dr. Saundra Yancy McGuire
MCIRCC Re-Imagining Critical Care Seminar Series (February 17, 2020 3:00pm) https://events.umich.edu/event/71948 71948-17903306@events.umich.edu Event Begins: Monday, February 17, 2020 3:00pm
Location: North Campus Research Complex Building 10
Organized By: Michigan Center for Integrative Research in Critical Care (MCIRCC)

“Innovation Fundamentals & Opportunities in Critical Care Biomarker Discovery”

Frederick Korley MD, PhD is an Associate Professor of Emergency Medicine.

Dr. Korley's research activities involve translation of novel diagnostics to inform clinically rational, timely, and cost-effective diagnosis of cardiac and brain injury in the emergency department. The goal of his traumatic brain injury work is to improve the acute care diagnosis, risk-stratification and treatment of TBI by identifying distinct molecular subtypes of TBI that will allow for targeted treatment and improved outcomes.

DETAILS & REGISTRATION:
http://bit.ly/FrederickKorley

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Workshop / Seminar Thu, 23 Jan 2020 12:02:33 -0500 2020-02-17T15:00:00-05:00 2020-02-17T16:00:00-05:00 North Campus Research Complex Building 10 Michigan Center for Integrative Research in Critical Care (MCIRCC) Workshop / Seminar MCIRCC Re-Imagining Critical Care Seminar Series with Dr. Frederick K. Korley Flyer
Bone Marrow Donor Drive (February 18, 2020 10:30am) https://events.umich.edu/event/72981 72981-18123057@events.umich.edu Event Begins: Tuesday, February 18, 2020 10:30am
Location:
Organized By: Wolverines for Life

oin Wolverines for Life at Pierpont Commons to help recruit bone marrow donors. This drive was established to help find a match for Natalia, an 8-year-old girl who may need a bone marrow donor soon.

Natalia was diagnosed with acute myeloid leukemia in August 2019. She has been hospitalized for most of the last few months at University of Michigan’s Mott Children’s Hospital, where she is undergoing chemotherapy. She has about 4 more months to go. Natalia has a very positive attitude. She loves to read (especially Percy Jackson and Warriors books) and do craft projects. Her nurses and doctors love her!

Hopefully chemo will be enough to cure Natalia’s condition. If it isn’t, she will need a bone marrow transplant. As of now, there are NO full matches in the bone marrow registries worldwide. Her 13-year-old brother and her twin sister are not matches.

Natalia’s mixed-race background – Cantonese, Latina (Salvadoran), and white (Dutch/German) – makes it especially hard to find a match. Her bone marrow HLA markers are predominantly Cantonese/white.

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Other Mon, 17 Feb 2020 12:05:16 -0500 2020-02-18T10:30:00-05:00 2020-02-18T17:00:00-05:00 Wolverines for Life Other Natalia
Genetics Training Program / CMB Short Course (630) (February 18, 2020 3:00pm) https://events.umich.edu/event/72320 72320-17974673@events.umich.edu Event Begins: Tuesday, February 18, 2020 3:00pm
Location: Medical Science Unit II
Organized By: Department of Human Genetics

Welcome to the Exciting World of Tandem and Interspersed DNA Repeat Elements
Presented By Jayakrishnan Nandakumar, Ph.D.
Associate Professor
Department of Molecular, Cellular, and Developmental Biology University of Michigan Medical School
Tuesday, February 18, 2020
3:00 p.m.
West Lecture Hall, Med Sci II

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Lecture / Discussion Fri, 31 Jan 2020 13:25:19 -0500 2020-02-18T15:00:00-05:00 2020-02-18T16:00:00-05:00 Medical Science Unit II Department of Human Genetics Lecture / Discussion Nandakumar GTP / CMB Short Course Flyer
Professional Autobiography (February 18, 2020 7:00pm) https://events.umich.edu/event/72925 72925-18094771@events.umich.edu Event Begins: Tuesday, February 18, 2020 7:00pm
Location: Couzens Hall
Organized By: HSSP

Have you ever wondered how health care professionals end up in their careers? Professional Autobiographies are excellent opportunities for students to hear directly from health care professionals in an informal setting. During these talks, students will learn about speakers' motivations for their career choices, how their interests and experiences influenced their career trajectories, and how they’ve worked to align their passion(s) with their work. These sessions provide an excellent opportunity to connect with professionals who may be able to provide valuable advice during your Michigan career.

All HSSP-sponsored Professional Autobiographies are open to the public.

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Lecture / Discussion Fri, 14 Feb 2020 11:41:54 -0500 2020-02-18T19:00:00-05:00 2020-02-18T20:00:00-05:00 Couzens Hall HSSP Lecture / Discussion Leon Golson
BME Ph.D. Defense: Lauren L. Zimmerman (February 20, 2020 10:00am) https://events.umich.edu/event/72566 72566-18018159@events.umich.edu Event Begins: Thursday, February 20, 2020 10:00am
Location: Lurie Robert H. Engin. Ctr
Organized By: Biomedical Engineering

Department of Biomedical Engineering Final Oral Examination

Lauren L. Zimmerman

Investigating Neuromodulation as a Treatment for Female Sexual Dysfunction

Female sexual dysfunction (FSD) affects millions of women worldwide. FSD has a significant impact on quality of life and interpersonal relationships. The prevalence of at least one form of sexual dysfunction is 40-45% of adult women with 12% of women experiencing sexually related personal distress, yet there is no clear treatment option for a wide range of FSD deficits with high efficacy and low side effects.

Neuromodulation techniques using electrical stimulation of peripheral nerves have the potential to treat some forms of FSD. In clinical trials of sacral neuromodulation (SNM) and percutaneous tibial nerve stimulation (PTNS) for bladder dysfunction, women have reported that their sexual dysfunction symptoms improved as well. Even though this effect has been observed clinically, very little research has been done to examine the mechanisms or the optimal method of treatment specifically for women with FSD. This thesis aims to bridge that gap by investigating neuromodulation as a treatment for FSD through both preclinical and clinical studies.

The first aim of this thesis is to investigate a possible mechanism of the improvement to sexual functioning in response to tibial nerve stimulation by evaluating vaginal blood flow responses in rats. In 16 ketamine-anesthetized female rats, the tibial nerve was stimulated for 30 minutes while vaginal blood perfusion was recorded with laser Doppler flowmetry. A novel signal analysis and quantification metric was developed for this analysis. I found that tibial nerve stimulation could drive prolonged increases in vaginal blood perfusion, typically after 20-30 minutes of stimulation. This result suggests that clinical neuromodulation may be improving FSD symptoms by increasing genital blood flow.

One question yet to be investigated by neuromodulation studies is whether tibial nerve stimulation could be an on-demand treatment for FSD, such as Viagra is for men, or is more appropriate as a long-term treatment with improvements over time, such as PTNS for bladder dysfunction. In this thesis I address this question by evaluating the sexual motivation and receptivity of female rats both immediately after a single stimulation session as well as after long-term, repeated stimulation sessions. I found that tibial nerve stimulation led to modest increases in sexual motivation in the short term, and larger increases in sexual receptivity in the long-term.

Lastly, this thesis evaluates a pilot clinical study of transcutaneous stimulation of the dorsal genital and posterior tibial nerves in nine women with FSD. The women received stimulation once a week for 12 weeks and their sexual functioning was measured using the Female Sexual Function Index (FSFI) at baseline, after 6 weeks of stimulation, after 12 weeks of stimulation, and at 18 weeks (6 weeks after the last stimulation session). The average total FSFI score across all subjects significantly increased from baseline to each of the time points in the study. Significant FSFI increases were seen in the sub-domains of lubrication, arousal, and orgasm, each of which is related to genital arousal.

This thesis provides evidence that peripheral neuromodulation can be an effective treatment for FSD. The stimulation is likely driving increases in genital blood flow, with greater effects observed when stimulation is repeatedly applied over time. This treatment has the potential to help millions of women worldwide.

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Lecture / Discussion Wed, 05 Feb 2020 15:00:05 -0500 2020-02-20T10:00:00-05:00 2020-02-20T11:00:00-05:00 Lurie Robert H. Engin. Ctr Biomedical Engineering Lecture / Discussion BME Logo
"Considering Disability: Religion and Human Limitation in Medical Contexts" (February 20, 2020 12:00pm) https://events.umich.edu/event/72365 72365-17998145@events.umich.edu Event Begins: Thursday, February 20, 2020 12:00pm
Location: Medical Science Unit II
Organized By: The University of Michigan Medical School Program on Health, Spirituality and Religion

The Woll Family Speaker Series on Health, Spirituality and Religion presents Sarah Barton, THD, MS, OTR/L, BCP

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Workshop / Seminar Mon, 03 Feb 2020 09:44:22 -0500 2020-02-20T12:00:00-05:00 2020-02-20T13:00:00-05:00 Medical Science Unit II The University of Michigan Medical School Program on Health, Spirituality and Religion Workshop / Seminar
Microfluidics Seminar: Dr. Xufeng Xue (February 20, 2020 12:00pm) https://events.umich.edu/event/73026 73026-18129602@events.umich.edu Event Begins: Thursday, February 20, 2020 12:00pm
Location: Pierpont Commons
Organized By: Biomedical Engineering

Neurulation is a key embryonic developmental process that gives rise to neural tube (NT), the precursor structure that eventually develops into the central nervous system (CNS). Understanding the molecular mechanisms and morphogenetic events underlying human neurulation is important for the prevention and treatment of neural tube defects (NTDs) and neurodevelopmental disorders. However, animal models are limited in revealing many fundamental aspects of neurulation that are unique to human CNS development. Furthermore, the technical difficulty and ethical constraint in accessing neurulation-stage human embryos have significantly limited experimental investigations of early human CNS development.
I leveraged the developmental potential and self-organizing property of human pluripotent stem cells (hPSCs) in conjunction with 2D and 3D bioengineering tools to achieve the development of spatially patterned multicellular tissues that mimic certain aspects of human neurulation, including neuroectoderm patterning and dorsal-ventral (DV) patterning of NT.
In the first section, I report a micropatterned hPSC-based neuroectoderm model, wherein pre-patterned geometrical confinement induces emergent patterning of neuroepithelial (NE) and neural plate border (NPB) cells, mimicking neuroectoderm patterning during early neurulation. My data support the hypothesis that in this hPS cell-based neuroectoderm patterning model, two tissue-scale morphogenetic signals, cell shape and cytoskeletal contractile force, instruct NE / NPB patterning via BMP-SMAD signaling. This work provides evidence of tissue mechanics-guided neuroectoderm patterning and establishes a tractable model to study signaling crosstalk involving both biophysical and biochemical determinants in neuroectoderm patterning.
In the second section, I report a human NT development model, in which NT-like tissues, termed NE cysts, are generated in a bioengineered neurogenic environment through self-organization of hPSCs. DV patterning of NE cysts is achieved using retinoic acid and/or Sonic Hedgehog, featuring sequential emergence of the ventral floor plate, p3 and pMN domains in discrete, adjacent regions and dorsal territory that is progressively restricted to the opposite dorsal pole.

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Lecture / Discussion Tue, 18 Feb 2020 08:58:46 -0500 2020-02-20T12:00:00-05:00 2020-02-20T13:00:00-05:00 Pierpont Commons Biomedical Engineering Lecture / Discussion BME Logo
BME 500: Ruixuan Gao (February 20, 2020 4:00pm) https://events.umich.edu/event/70421 70421-17594473@events.umich.edu Event Begins: Thursday, February 20, 2020 4:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Investigation of the molecular basis of a complex biological system, such as the brain, can lead to fundamental understanding of its composition and function, and to a new strategy to repair it. Such investigation, however, requires a tool that can capture biological structures and their molecular constituents across multiple orders of magnitude—from nanometers to centimeters—in length. Electron microscopy offers nanoscopic resolution but lacks molecular information to differentiate endogenous biomolecules as well as imaging speed to cover millimeter-scale specimens. Light microscopy provides molecular contrast but is limited by optical diffraction and the tradeoff between imaging speed and photobleaching.

In this talk, I will first introduce an optical imaging pipeline named expansion lattice light-sheet microscopy (ExLLSM) and its application to multiplexed, volumetric imaging of molecular constituents in cells and intact tissues. Using ExLLSM, our study has revealed molecular-specific structures of organelles, synapses, myelin sheaths, and neurites in rodent and insect brains at ∼60 by 60 by 90 nm effective resolution across dimensions that span millimeters. Next, I will present two recently developed methods that further extend the resolution and throughput of ExLLSM: (1) a non-radical hydrogel chemistry that forms a homogenous polymer network and physically separates biomolecules or fluorescent labels up to 40-fold linearly, and (2) a multi-modal optical microscopy that enables rapid, high-resolution imaging of both expanded and live tissues. Lastly, I will discuss the significance of these imaging methods in the context of microanatomy and functional omics.

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Lecture / Discussion Thu, 13 Feb 2020 10:34:18 -0500 2020-02-20T16:00:00-05:00 2020-02-20T17:00:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Lecture / Discussion BME Logo
Medical School Student Panel Discussion (February 20, 2020 5:30pm) https://events.umich.edu/event/72115 72115-17939978@events.umich.edu Event Begins: Thursday, February 20, 2020 5:30pm
Location: Undergraduate Science Building
Organized By: Science Learning Center

Here is your chance to hear about what life is like for several medical school students and residents. Learn about each of their paths to medicine, experiences in medical school, and things they wished they had known in college.

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Workshop / Seminar Mon, 27 Jan 2020 12:42:55 -0500 2020-02-20T17:30:00-05:00 2020-02-20T18:30:00-05:00 Undergraduate Science Building Science Learning Center Workshop / Seminar
Science as Art Exhibition- Panel discussion & Awards Reception (February 21, 2020 2:00pm) https://events.umich.edu/event/38185 38185-17963890@events.umich.edu Event Begins: Friday, February 21, 2020 2:00pm
Location: Hatcher Graduate Library
Organized By: Arts at Michigan

Arts at Michigan, ArtsEngine and the Science Learning Center invite you to the Science as Art Contest Exhibition and Awards Reception- Hatcher Graduate Library, Rm 100.

2pm Office Hours for participating artists
3pm Panel Discussion & Reception
4pm Awards Announcements


University of Michigan undergraduate students will have artwork on view expressing a scientific principle, concept, idea, process, or structure. The artwork ranges in media, including visual, literary, musical, video and performance-based art. A juried panel using criteria based on both scientific and artistic considerations will choose winning submissions. This is our fourth year of the exhibition, and we received a record number of submissions, so we hope you'll join us to view the work and give out the awards!

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Exhibition Thu, 30 Jan 2020 11:57:18 -0500 2020-02-21T14:00:00-05:00 2020-02-21T16:30:00-05:00 Hatcher Graduate Library Arts at Michigan Exhibition Science as Art logo
LHS Collaboratory (February 25, 2020 12:00pm) https://events.umich.edu/event/72208 72208-18035597@events.umich.edu Event Begins: Tuesday, February 25, 2020 12:00pm
Location: 1027 E. Huron Building
Organized By: Department of Learning Health Sciences

"Value Proposition of Learning Health Systems"
Erik Gordon, PhD
Clinical Assistant Professor, Ross School of Business, University of Michigan
Tuesday, February 25, 2020 – 12 pm–1:30 pm
Great Lakes Room, Palmer Commons (Lunch is included)

Professor Gordon's areas of interest are entrepreneurship and technology commercialization, venture capital, private equity, mergers and acquisitions, corporate governance, the biomedical industry (pharmaceuticals, devices, healthcare big data, and biotechnology), IoT, FinTech, and digital and mobile marketing. He also served on the faculty of University of Michigan Law School. He has served on the faculty and as Associate Dean and Director of the Graduate Division of Business & Management (Carey Business School) at Johns Hopkins University, where he taught in the business and medical schools and at the University of Florida, where he also served as director of the Center for Technology & Science Commercialization Studies and as Director of MBA Programs. He has served as an adviser or co-founder to numerous companies. He is frequently quoted in The New York Times, BusinessWeek, The Wall Street Journal, Bloomberg, Reuters and other outlets, is a regular contributor to Marketplace Morning Report (in NPR's Morning Edition), Bloomberg Radio, and appears on PBS's Nightly Business Report. His degrees are in economics and law.
Please register in advance, dlhs-umi.ch/lhs-collaboratory.
Email: LHScollaboratory-info@umich.edu

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Lecture / Discussion Fri, 07 Feb 2020 15:07:52 -0500 2020-02-25T12:00:00-05:00 2020-02-25T13:30:00-05:00 1027 E. Huron Building Department of Learning Health Sciences Lecture / Discussion LHS Collaboratory
BME 500: Kelly Stevens (February 27, 2020 4:00pm) https://events.umich.edu/event/70067 70067-17505693@events.umich.edu Event Begins: Thursday, February 27, 2020 4:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

The notion of building artificial human organs has moved from a far-fetched concept to the forefront of regenerative medicine research. While progress is being made, most tissues created to date are simply not large enough to support clinically meaningful functions, and their structural features remain an magnitude coarser in resolution than native tissues. Few organs better represent this challenge than the liver – the largest visceral organ in the human body, in which hepatocytes are aligned in single cell-width structures entangled with vascular and biliary networks. To address this challenge, we are working to develop a portfolio of tools that integrate 3D printing, synthetic biology, and the innate capacity of cells to self-assemble. We are applying these tools to decode the signals that drive tissue assembly during development, and using this information to build scaled artificial tissues that replicate the features of native tissues.

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Workshop / Seminar Thu, 20 Feb 2020 11:04:16 -0500 2020-02-27T16:00:00-05:00 2020-02-27T17:00:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar BME Event
2020 MASSEY TBI GRAND CHALLENGE KICKOFF (March 5, 2020 8:30am) https://events.umich.edu/event/69927 69927-17489276@events.umich.edu Event Begins: Thursday, March 5, 2020 8:30am
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Integrative Research in Critical Care (MCIRCC)

The Massey TBI Grand Challenge supports high-impact proposals by funding milestone-driven research over a 12-month timeframe.

This event is made possible thanks to a generous gift from the Joyce and Don Massey Family Foundation. Up to $650,000 is available in 2020 to fund the development of diagnostic, device, therapeutic, or health IT solutions that address the initial ‘golden hours’ of care after severe traumatic brain injury (generally the first 48 hours). Additionally, this year ALL current/past awardees and new awardees will be eligible for the Schwabauer Accelerator Award of $40,000. This will be a separate application.

Note: To be considered for funding, you must attend the Grand Challenge event.

Keynote Speaker:
Odette Harris, MD, MPH, Stanford University School of Medicine

DETAILS & REGISTRATION:
http://bit.ly/2020-TBI-Grand-Challenge

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Other Thu, 23 Jan 2020 12:04:54 -0500 2020-03-05T08:30:00-05:00 2020-03-05T16:00:00-05:00 North Campus Research Complex Building 18 Michigan Center for Integrative Research in Critical Care (MCIRCC) Other 2020 Massey TBI Grand Challenge
BME 500: Ruobo Zhou (March 5, 2020 4:00pm) https://events.umich.edu/event/73399 73399-18214945@events.umich.edu Event Begins: Thursday, March 5, 2020 4:00pm
Location: Industrial and Operations Engineering Building
Organized By: Biomedical Engineering

Biomolecular interactions are at the root of all biological processes and define the molecular mechanisms of how these processes are accomplished in both physiological and pathological conditions. Recent advances in single molecule detection and super-resolution fluorescence microcopy have uncovered previously unknown properties of biomolecular interactions, including multivalency, transiency, and heterogeneity, and revealed the organizational principles governing the compartmentalization of functional biomolecular interactions in cells and how such compartmentalization and organizations become dysregulated in diseases. In this talk, I will first discuss my postdoctoral work, where I used mass-spectrometry-based analysis and super-resolution imaging to dissect the protein-protein interactions at the plasma membrane of neurons, and discovered that a newly identified membrane-associated periodic skeleton (MPS) structure can function as a signaling platform that coordinates the interactions of signaling proteins at the plasma membrane of neurons. In response to extracellular stimuli, G-protein coupled receptors, cell-adhesion molecules, receptor tyrosine kinases can be recruited to the MPS to form signaling complexes at the plasma membrane, and such recruitment is required for downstream intracellular signaling. This work not only reveals an important, previously unknown function of the newly discovered MPS structure, but also provides novel mechanistic insights into signal transduction in neurons. I will then discuss my graduate work, where I developed a hybrid single molecule technique combining single molecule FRET and optical tweezers, and applied this technique to probe the sub-molecular dynamics of protein-DNA interactions in various biological systems involved in DNA replication, repair and recombination.

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Lecture / Discussion Fri, 28 Feb 2020 11:07:38 -0500 2020-03-05T16:00:00-05:00 2020-03-05T17:00:00-05:00 Industrial and Operations Engineering Building Biomedical Engineering Lecture / Discussion BME Logo
Epidemiology and dynamics of the coronavirus (COVID-19) epidemic (March 10, 2020 11:30am) https://events.umich.edu/event/73197 73197-18157926@events.umich.edu Event Begins: Tuesday, March 10, 2020 11:30am
Location: Weiser Hall
Organized By: The Center for the Study of Complex Systems

The novel coronavirus COVID-19 epidemic is currently leveling off in China but on the upswing in the rest of the world. Understanding and modeling this growth is obviously of high importance. We noticed that for several weeks, the number of deaths in China could be fit by a power law with exponent of about 2.25, suggesting a kind of fractal or small-world behavior going on. Traditional epidemiological models, such as the Susceptible-Exposed-Infected-Recovered models (SEIR) puts groups in compartments and use differential equations to predict the behavior, but there is no spatial or network properties taken into account. At early times, the growth is exponential depending upon the reproduction rate, and for later times those models predict an s-shaped curve. The power-law result predicted a greater growth of the epidemic than many people were predicting. More recently, the daily deaths in China have dropped off exponentially, in fact following a model of A. Vazquez from 2006. At the same time, the growth in the number of total deaths in other parts of the world is tracking the behavior in China, delayed by one month. The small-world, fractal idea suggested that this world-wide transmission was likely to take place, and the belief that it could be contained in China was clearly short-sighted.

Reference: A. L. Ziff and R. M. Ziff, medrXiv 2020 submitted.

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Workshop / Seminar Tue, 03 Mar 2020 23:51:52 -0500 2020-03-10T11:30:00-04:00 2020-03-10T13:00:00-04:00 Weiser Hall The Center for the Study of Complex Systems Workshop / Seminar Robert Ziff
Forum on "Climate Change and Health: Readiness and Resilience" (March 10, 2020 12:00pm) https://events.umich.edu/event/72763 72763-18070598@events.umich.edu Event Begins: Tuesday, March 10, 2020 12:00pm
Location: Towsley Center for Cont. Med Ed
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

*Please register by going to http://mleead.umich.edu/Event_Climate_Change_and_Health_2020.php*

Our climate is our planet’s life support system. Climate change influences human health and disease in numerous ways, including impacts from increased extreme weather events, wildfire, decreased air quality, and illnesses transmitted by food, water, and disease carriers such as mosquitoes and ticks. As described in the Lancet Countdown report, some existing health threats will intensify and new health threats will emerge. Not everyone is equally at risk, and children are especially at risk. Preventive and adaptive actions are needed.

The keynote speaker is an emergency medicine physician who co-authored the U.S. portion of the Lancet Countdown report and Health and Care Delivery in the New England Journal of Medicine. A panel of experts will present solutions from a variety of other universities who are reducing their carbon footprint in response to the urgent public health need.

Welcome: Joseph C. Kolars, MD, Senior Associate Dean for Education and Global Initiatives, UM Medical School

Keynote: "Climate Action: Children’s Health Drives Need for Urgent Action" Renee N. Salas, MD, MPH, MS, Clinical Instructor of Emergency Medicine, Harvard Medical School and emergency medicine physician, Massachusetts General Hospital

Schedule
11:00-11:45 am | Registration outside of Dow Auditorium, Towsley Center for Continuing Medical Education, Michigan Medicine
11:00-11:45 am | Lunch in Towsley Center Dining Room for registered guests
12:00-1:30 pm | Program in Dow Auditorium, Towsley Center (also will be live streamed)
1:30-2:00 pm | Reception in Towsley Center Dining Room

*Please register by going to http://mleead.umich.edu/Event_Climate_Change_and_Health_2020.php*

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Conference / Symposium Fri, 21 Feb 2020 13:52:24 -0500 2020-03-10T12:00:00-04:00 2020-03-10T13:30:00-04:00 Towsley Center for Cont. Med Ed Michigan Lifestage Environmental Exposures and Disease Center Conference / Symposium Climate Change and Health: Readiness and Resilience
Bioethics Discussion: Public Health (March 10, 2020 7:00pm) https://events.umich.edu/event/52728 52728-12974162@events.umich.edu Event Begins: Tuesday, March 10, 2020 7:00pm
Location: Lurie Biomedical Engineering
Organized By: The Bioethics Discussion Group

A discussion on the health of our society.

Readings to consider:
1. The right to public health
2. Ethics and Public Health: Forging a Strong Relationship
3. Old Myths, New Myths: Challenging Myths in Public Health
4. A Bridge Back to the Future: Public Health Ethics, Bioethics, and Environmental Ethics

For more information and/or to receive a copy of the readings contact Barry Belmont at belmont@umich.edu or visit http://belmont.bme.umich.edu/bioethics-discussion-group/discussions/042-public-health/.

A public good for the good of the public – the blog: https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Thu, 09 Jan 2020 09:57:57 -0500 2020-03-10T19:00:00-04:00 2020-03-10T20:30:00-04:00 Lurie Biomedical Engineering The Bioethics Discussion Group Lecture / Discussion Public health
DCMB Weekly Seminar (March 11, 2020 4:00pm) https://events.umich.edu/event/73002 73002-18123077@events.umich.edu Event Begins: Wednesday, March 11, 2020 4:00pm
Location:
Organized By: DCMB Seminar Series

Abstract:

In this talk, some major challenges are reviewed of using Artificial Intelligence (AI) to address the needs of medicine and healthcare. These challenges include technical issues such as data-related and/or algorithmic challenges that the use of AI for medicine would present. The speaker then presents some potential solutions in form of novel algorithmic approaches that may at least partially address some of these challenges.

BlueJeans livestream: https://primetime.bluejeans.com/a2m/live-event/rbuvycdc

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Lecture / Discussion Wed, 11 Mar 2020 08:49:28 -0400 2020-03-11T16:00:00-04:00 2020-03-11T17:00:00-04:00 DCMB Seminar Series Lecture / Discussion
CANCELED Karma Masters: the Personhood of Tumors and their People in Northern Thailand (March 13, 2020 3:00pm) https://events.umich.edu/event/73475 73475-18243514@events.umich.edu Event Begins: Friday, March 13, 2020 3:00pm
Location: West Hall
Organized By: Department of Anthropology

How can one make sense of ethical action when one is partly the other? In contexts of critical illness in Northern Thailand, many consider broken parts of themselves - from tumors to torn nerves to psychotic voices - to be beings returned to exact revenge for past wrongs. Many thus endeavor to treat their parts well, including their tumors. In this talk, I explore the implications of this hybrid personhood for living an ethical life, opening the possibility of ethical interaction, forgiveness, and love without individuality.

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Lecture / Discussion Thu, 12 Mar 2020 11:40:38 -0400 2020-03-13T15:00:00-04:00 2020-03-13T17:00:00-04:00 West Hall Department of Anthropology Lecture / Discussion karma masters
POSTPONED: An Evidence-Based Approach to Concussion Care: Using Physiology to Advance Clinical Practice (March 16, 2020 11:00am) https://events.umich.edu/event/73717 73717-18304814@events.umich.edu Event Begins: Monday, March 16, 2020 11:00am
Location: Palmer Commons
Organized By: Biosciences Initiative

Concussion Center Faculty Candidate Research Presentation
Presentation 11 a.m. - noon, Reception noon - 12:30 p.m.

Although concussions are a common injury in sport and recreational activities, they remain one of the most difficult injuries for clinicians to diagnose and manage. Dr. Teel’s primary research interests intersect physiological and clinical outcomes in children and adults with concussion to identify injury, promote recovery, and enhance quality of life. In this talk, she will discuss how her research fills current gaps in the literature.

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Lecture / Discussion Mon, 16 Mar 2020 14:16:42 -0400 2020-03-16T11:00:00-04:00 2020-03-16T12:30:00-04:00 Palmer Commons Biosciences Initiative Lecture / Discussion Michigan Concussion Center
Virtual International Institute Round Table. Coronavirus: Global Academic Perspectives (March 17, 2020 4:00pm) https://events.umich.edu/event/73766 73766-18313581@events.umich.edu Event Begins: Tuesday, March 17, 2020 4:00pm
Location:
Organized By: International Institute

The livestream will be at: https://ii.umich.edu/ii/news-events/all-events/livestream-events.html

The rapid emergence and spread of COVID-19 has created a global health crisis. This panel of experts will discuss the coronavirus and the implications for the world at large, as well as the University of Michigan.

The II Round Table will be presented as a live webcast. Follow the discussion and post questions during the event on Twitter using #IIRoundTable and @iimichigan.

Moderator:
Joseph C. Kolars, MD
Senior Associate Dean for Education and Global Initiatives, Medical School


Panelists:
Joseph N.S. Eisenberg, PhD, MPH
Chair and Professor of Epidemiology, Professor of Global Public Health

Amy Huang, MD, MHSA
Director of Asia Programs
Global REACH

Preeti Malani, MD, MSJ
Chief Health Officer and Professor of Medicine

Howard Markel, MD, PhD
George E. Wantz, M.D. Distinguished Professor of the History of Medicine

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Livestream / Virtual Tue, 17 Mar 2020 15:21:55 -0400 2020-03-17T16:00:00-04:00 2020-03-17T17:30:00-04:00 International Institute Livestream / Virtual Coronavirus: Global Academic Perspectives
Mindfulness Mingle focus group and dinner for faculty and students (March 17, 2020 5:30pm) https://events.umich.edu/event/73562 73562-18261069@events.umich.edu Event Begins: Tuesday, March 17, 2020 5:30pm
Location: Palmer Commons
Organized By: Center for Interprofessional Education

Dive into mindfulness with Michigan Center for IPE faculty fellows and Michigan Medicine's Dr. Frank Anderson on March 17 -- and get dinner and thank you gift card while you are at it! Space is limited; advance registration required.

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Presentation Wed, 04 Mar 2020 13:44:44 -0500 2020-03-17T17:30:00-04:00 2020-03-17T19:00:00-04:00 Palmer Commons Center for Interprofessional Education Presentation Be Mindful!
CANCELLED - Parenting for Prison: Time for One is Time for All (March 17, 2020 6:00pm) https://events.umich.edu/event/73203 73203-18377654@events.umich.edu Event Begins: Tuesday, March 17, 2020 6:00pm
Location:
Organized By: Prison Birth Project

This semester, Prison Birth Project is hosting its second annual symposium, Parenting from Prison: Time for One is Time for All.

We aim to raise awareness and foster a discussion about our state’s prison system and the negative effects it has on those that are incarcerated and their loved ones in order to work collaboratively towards systematic changes.

The symposium will feature keynote speaker Cindy Shank, a previously incarcerated activist and advocate for abolishing mandatory minimum sentences. There will be several breakout workshop options relating to birth in prison, criminal justice advocacy, and diversion programs. There will also be a presentation about a current bill related to criminal justice advocacy.

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Conference / Symposium Tue, 17 Mar 2020 18:53:21 -0400 2020-03-17T18:00:00-04:00 2020-03-17T19:00:00-04:00 Prison Birth Project Conference / Symposium Parenting from Prison: Time for One is Time for All
CANCELED: "Human Nature" panel discussion (March 18, 2020 7:30pm) https://events.umich.edu/event/72924 72924-18096982@events.umich.edu Event Begins: Wednesday, March 18, 2020 7:30pm
Location: Off Campus Location
Organized By: Precision Health

THE PANEL DISCUSSION HAS BEEN CANCELED.

For information about the film, please see Michigan Theater's website:
https://www.michtheater.org/show/human-nature/

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Film Screening Thu, 12 Mar 2020 09:49:25 -0400 2020-03-18T19:30:00-04:00 2020-03-18T22:00:00-04:00 Off Campus Location Precision Health Film Screening Human Nature
CANCELED! From Laboratory to Population: Molecular Epidemiology in Action (March 20, 2020 9:00am) https://events.umich.edu/event/71052 71052-17768679@events.umich.edu Event Begins: Friday, March 20, 2020 9:00am
Location: Rackham Graduate School (Horace H.)
Organized By: MAC-EPID

"Antibiotic use during pregnancy: Too much of a good thing?"
Lixin Zhang, PhD (Assistant Professor, Epidemiology & Biostatistics and Microbiology & Molecular Genetics, Michigan State University)

"Group B streptococcal epidemiology and pathogenesis: A tribute to Carl Marrs’ mentorship"
Shannon Manning, PhD (MSU Foundation Associate Professor of Microbiology and Molecular Genetics, Michigan State University)

"Integrating Operational Research to Combat Epidemics: Investigating Ebola Infection among Health Workers in Kenema, Sierra Leone, 2014"
Mikiko Senga, PhD (Disease Outbreak Team Lead, Health Emergencies Programme, World Health Organization, Yemen)

Epidemiology Alumni Reception directly following talks.

Please register for this free symposium since lunch will be provided. Thank you!

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Conference / Symposium Wed, 11 Mar 2020 16:26:18 -0400 2020-03-20T09:00:00-04:00 2020-03-20T16:00:00-04:00 Rackham Graduate School (Horace H.) MAC-EPID Conference / Symposium CANCELED Flyer
Ph.D. Defense: Ahmad Asif A Jiman (March 24, 2020 10:00am) https://events.umich.edu/event/73841 73841-18426650@events.umich.edu Event Begins: Tuesday, March 24, 2020 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be hosted via Zoom. You can log in with this link:

https://umich.zoom.us/j/329580834
Meeting ID: 329-580-834

Diabetic patients suffer from a long-term condition that results in high blood glucose levels (hyperglycemia). Many medications for diabetes lose their glycemic control effectiveness over time and patient compliance to these medications is a major challenge. Glycemic control is a vital continuous process and is innately regulated by the endocrine and autonomic nervous systems. There is an opportunity for developing an implantable and automated treatment for diabetic patients by accurately detecting and altering neural activity in autonomic nerves. The renal and vagus nerves contribute in glycemic control and are potential targets for this proposed treatment. This dissertation investigated stimulation of renal nerves for glycemic control, assembled an implantation procedure for neural interface arrays designed for autonomic nerves, and demonstrated high-fidelity physiological signals in the vagus nerve of rats.

Stimulation of renal nerves at kilohertz frequency (33 kHz) showed a notable average increase in urine glucose excretion (+24.5%). In contrast, low frequency (5 Hz) stimulation of renal nerves showed a decrease in glucose excretion (−40.4%). However, these responses may be associated with urine flow rate.

Kilohertz frequency stimulation (50 kHz) of renal nerves in diabetic rats showed a significant average decrease (-168.4%) in blood glucose concentration rate, and an increase (+18.9%) in the overall average area under the curve for urine glucose concentration, with respect to values before stimulation.

An innovative procedure was assembled for the chronic implantation of novel intraneural MIcroneedle Nerve Arrays (MINAs) in rat vagus nerves. Two array attachment approaches (fibrin sealant and rose-bengal bonding) were investigated to secure non-wired MINAs in rat vagus nerves. The fibrin sealant approach was unsuccessful in securing the MINA-nerve interface for 4- and 8-week implant durations. The rose-bengal coated MINAs were in close proximity to axons (≤ 50 μm) in 75% of 1-week and 14% of 6-week implants with no significant harm to the implanted nerves or the overall health of the rats.

Using Carbon Fiber Microelectrode Arrays (CFMAs), physiological neural activity was recorded on 51% of inserted functional carbon fibers in rat vagus nerves, and 1-2 neural clusters were sorted on each carbon fiber with activity. The mean peak-to-peak amplitudes of the sorted clusters were 15.1-91.7 µV with SNR of 2.0-7.0. Propagation of vagal signals were detected in the afferent direction at conduction velocities of 0.7-1.0 m/sec, and efferent signals at 0.7-8.8 m/sec, which are within the conduction velocity range of myelinated and unmyelinated vagus fibers. Furthermore, changes in vagal nerve activity were monitored in breathing and blood glucose modulated conditions.

Overall, this dissertation investigated modulation of neural activity for glycemic control, assembled a new chronic implantation procedure for nerve interface arrays, and monitored physiological signaling in an autonomic nerve. Future work is needed to fully understand the physiological neural signaling, and evaluate the long-term tissue reactivity and recording integrity of implanted electrodes in autonomic nerves. This work supports the potential development of an alternative implantable treatment modality for diabetic patients by modulating and monitoring neural activity in autonomic nerves.

Date: Tuesday, March 24, 2020
Time: 10:00 AM
Location: North Campus Research Complex (NCRC), B10-G64
Chair: Dr. Tim M. Bruns

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Lecture / Discussion Mon, 23 Mar 2020 14:08:39 -0400 2020-03-24T10:00:00-04:00 2020-03-24T11:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion U-M BME Event
LHS Collaboratory Webinar "Mobilizing Computable Biomedical Knowledge at Michigan Medicine" (March 24, 2020 12:00pm) https://events.umich.edu/event/72652 72652-18035599@events.umich.edu Event Begins: Tuesday, March 24, 2020 12:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Presentation 1:
"Electronic Health Record (EHR)-Integration for Learning Health Systems"

Michael Lanham, MD
Associate Chief Medical Information Officer
Clinical Assistant Professor of Learning Health Sciences
Assistant Professor of Obstetrics & Gynecology; Fertility and Reproductive Health
University of Michigan

Presentation 2:
“Machine Learning Infrastructure in a Learning Health System”

Karandeep Singh, MD, MMSc
Assistant Professor of Learning Health Sciences
Assistant Professor of Medicine
University of Michigan


Please register in advance, *dlhs-umi.ch/lhs-collaboratory. *
Email: *LHScollaboratory-info@umich.edu*

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Lecture / Discussion Wed, 18 Mar 2020 10:04:19 -0400 2020-03-24T12:00:00-04:00 2020-03-24T13:30:00-04:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion LHS Collaboratory
CANCELED/POSTPONED -- The Mothers of Gynecology: Examining U.S. Slavery and the Making of a Field (March 24, 2020 4:00pm) https://events.umich.edu/event/71643 71643-17851292@events.umich.edu Event Begins: Tuesday, March 24, 2020 4:00pm
Location: Lane Hall
Organized By: Institute for Research on Women and Gender

This event has been canceled/postponed as of 3/12/2020. Please stay tuned for future updates.

Deirdre Cooper Owens is the Linda and Charles Wilson Professor in the History of Medicine and Director of the Humanities in Medicine program at the University of Nebraska-Lincoln. She is an Organization of American Historians’ (OAH) Distinguished Lecturer and has won a number of prestigious honors that range from the University of Virginia’s Carter G. Woodson Postdoctoral Fellowship in the Woodson Institute for African-American and African Studies to serving as an American Congress of Obstetrics and Gynecology Fellow in Washington, D.C. Cooper Owens earned her Ph.D. from UCLA in History and wrote an award-winning dissertation while there. A popular public speaker, she has published articles, essays, book chapters, and think pieces on a number of issues that concern African American experiences and reproductive justice. Recently, Cooper Owens finished working with Teaching Tolerance and the Southern Poverty Law Center on a podcast series about how to teach U.S. slavery and Time Magazine listed her as an “acclaimed expert” on U.S. history in its annual “The 25 Moments From American History That Matter Right Now.” Her first book, Medical Bondage: Race, Gender and the Origins of American Gynecology (UGA Press, 2017) won the 2018 Darlene Clark Hine Book Award from the OAH as the best book written in African American women’s and gender history.

Professor Cooper Owens is also the Director of the Program in African American History at the Library Company of Philadelphia, the country’s oldest cultural institution founded by Benjamin Franklin in 1731. She is working on a second book project that examines mental illness during the era of United States slavery and is writing a popular biography of Harriet Tubman that examines her through the lens of disability.

This talk is presented by IRWG's program on Black Feminist Health Studies.

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Lecture / Discussion Thu, 12 Mar 2020 12:54:45 -0400 2020-03-24T16:00:00-04:00 2020-03-24T17:30:00-04:00 Lane Hall Institute for Research on Women and Gender Lecture / Discussion photo of Deirdre Cooper-Owens
Zhen Xu, PhD: Histotripsy Webinar (March 25, 2020 10:00am) https://events.umich.edu/event/73931 73931-18426654@events.umich.edu Event Begins: Wednesday, March 25, 2020 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This will be held online. Click the link below to register.

https://fusfoundation.zoom.us/webinar/register/WN_Hj_R2DMOT8SlOAp0WRLV3A

Oftentimes when we think of focused ultrasound, we imagine using it to heat and kill tissue. Unlike thermal ablation, histotripsy uses focused ultrasound to mechanically disrupt the target tissue without heating. Histotripsy turns the tissue into liquid-appearing acellular debris – which is absorbed by the body over one to two months – resulting in effective tissue removal.

Histotripsy has been shown to stimulate a powerful immune response in cancer treatment studies. In the treatment of neurological diseases, transcranial histotripsy can produce well-confined focal treatment in a wide range of locations and volumes in the brain, offering the potential to increase the treatment envelope while decreasing treatment time.

Please register to join us at 10:00 AM Eastern on Wednesday, March 25, when Zhen Xu, PhD, will discuss the basic mechanism, instrumentation, bioeffects, and applications of histotripsy. She will also cover the latest preclinical and clinical trial results of developing histotripsy for the treatment of cancer and neurological diseases.

About the Speaker

Zhen Xu, PhD, is a tenured Associate Professor in the Department of Biomedical Engineering at the University of Michigan and a primary inventor and pioneer in histotripsy.

She has received many notable awards, including:
IEEE Ultrasonics, Ferroelectrics, and Frequency Control Society Outstanding Paper Award (2006)
American Heart Association Outstanding Research in Pediatric Cardiology (2010)
National Institutes of Health (NIH) New Investigator Award at the First National Institute of Biomedical Imaging and Bioengineering (NIBIB) Edward C. Nagy New Investigator Symposium (2011)
The Federic Lizzi Early Career Award from The International Society of Therapeutic Ultrasound (ISTU) (2015)
Fellow of the American Institute of Medical and Biological Engineering (2019)
Dr. Xu is currently an associate editor for three notable journals: IEEE Transactions on Ultrasound, Ferroelectrics, and Frequency Control (UFFC); Frontiers in Bioengineering; and BME Frontiers. She is an elected board member of ISTU, a charter member of the US NIH study section, and a principal investigator of grants funded by the Focused Ultrasound Foundation, NIH, American Cancer Association, Office of Naval Research, The Hartwell Foundation, and The Coulter Foundation.

She received her PhD from the University of Michigan in 2005.

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Livestream / Virtual Mon, 23 Mar 2020 14:42:17 -0400 2020-03-25T10:00:00-04:00 2020-03-25T11:00:00-04:00 Off Campus Location Biomedical Engineering Livestream / Virtual BME Logo
Risks and Protective Factors of Dementia (March 25, 2020 6:00pm) https://events.umich.edu/event/69816 69816-17431805@events.umich.edu Event Begins: Wednesday, March 25, 2020 6:00pm
Location: Off Campus Location
Organized By: Michigan Alzheimer's Disease Center

Scott Roberts, PhD of the University of Michigan will
present: "Risks and Protective Factors of Dementia." Dr.
Roberts is a Professor of Health Behavior & Health
Education at the University of Michigan School of
Public Health and the Outreach, Recruitment, and
Engagement Core Leader of the Michigan Alzheimer's
Disease Research Center.

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Presentation Wed, 27 Nov 2019 10:52:55 -0500 2020-03-25T18:00:00-04:00 2020-03-25T20:00:00-04:00 Off Campus Location Michigan Alzheimer's Disease Center Presentation
Ph.D. Defense: Brittany Rodriguez (March 26, 2020 10:00am) https://events.umich.edu/event/73840 73840-18339520@events.umich.edu Event Begins: Thursday, March 26, 2020 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: Will be held via BlueJeans.

BlueJeans Link: https://umich.bluejeans.com/478989984

Volumetric muscle loss (VML) is the traumatic or surgical loss of skeletal muscle comprising 20-30% or more of the total muscle volume. By definition, VML exceeds the muscle’s capacity for self-repair and results in persistent functional deficits. Significantly, no treatment options exist that can fully restore native structure and function. To address the limitations of current treatments, our laboratory has developed tissue-engineered skeletal muscle units (SMUs) as a novel treatment for VML repair. SMUs have shown promising regenerative potential in a rat VML model; however, limitations of rodent models necessitated transitioning our technology to a large animal (sheep) model.



Despite substantial heterogeneity of muscle progenitor cell populations obtained from craniofacial, trunk, and limb muscle, engineered skeletal muscle tissues are almost exclusively fabricated from cells derived from hindlimb muscle, making the effects of cell source on engineered muscle tissue unknown. Thus, we conducted a comparison of SMUs fabricated from muscle cells isolated from both craniofacial and hindlimb muscle sources and evaluated the effects of these cell sources on SMU structure and function. Specifically, we showed that the semimembranosus muscle was the most clinically relevant muscle source for the fabrication of SMUs.

We also sought to develop a method to scale our SMUs to clinically relevant sizes. We developed a modular fabrication method that combines multiple smaller SMUs into a larger implantable graft. Consequently, we successfully fabricated of one of the largest engineered skeletal muscle tissues to date while avoiding the formation of a necrotic core. To treat peripheral nerve injuries that often accompany VML, we also developed engineered neural conduits (ENCs) to bridge gaps between healthy native nerve and the injury site. We used scaled-up SMUs and ENCs to treat a 30% VML in the ovine peroneus tertius muscle. After a 3-month recovery, SMU-treated groups restored muscle mass and force production to a level that was statistically indistinguishable from the uninjured contralateral muscle.

Lastly, we evaluated the efficacy of SMUs in repairing craniofacial VML. Despite reported differences in the regenerative capacity of craniofacial muscle compared to limb muscle, prior to my thesis there were no models of craniofacial VML in either large or small animal models. Thus, we introduced the first model of craniofacial VML and evaluated the ability of SMUs to treat a 30% VML in the zygomaticus major muscle. Despite using the same injury and repair model in both implantation studies, results showed differences in pathophysiology between craniofacial and hindlimb VML. The fibrotic response was increased in the facial muscle model, and there was tissue tethering and intramuscular fat deposition that was not observed in the hindlimb study. The craniofacial model was also confounded by concomitant denervation and ischemia injuries which was too severe for our SMUs to repair. This study highlighted the importance of balancing the use of a clinically realistic model while also maintaining control over variables related to the severity of the injury.

Overall, this work significantly contributed to the field of skeletal muscle tissue engineering by evaluating the effects of muscle source on the structure and function of SMUs, created a modular fabrication method for tissue scale-up, and introduced a new large animal model, and a craniofacial model of VML. The success of this technology demonstrates its potential for treating clinical VML in the future.

Chair: Dr. Lisa Larkin

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Lecture / Discussion Tue, 24 Mar 2020 14:49:10 -0400 2020-03-26T10:00:00-04:00 2020-03-26T11:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion U-M BME Event
Ph.D. Defense: Tyler Gerhardson (March 26, 2020 10:00am) https://events.umich.edu/event/73025 73025-18129601@events.umich.edu Event Begins: Thursday, March 26, 2020 10:00am
Location: Lurie Robert H. Engin. Ctr
Organized By: Biomedical Engineering

NOTICE: Will be held via BlueJeans.

Link: https://umich.bluejeans.com/924142541

Brain pathologies including stroke and cancer are a major cause of death and disability. Intracerebral hemorrhage (ICH) accounts for roughly 12% of all strokes in the US with approximately 200,000 new cases per year. ICH is characterized by the rupture of vessels resulting in bleeding and clotting inside the brain. The presence of the clot causes immediate damage to surrounding brain tissue via mass effect with delayed toxic effects developing in the days following the hemorrhage. This leads ICH patients to high mortality with a 40% chance of death within 30 days of diagnosis and motivates the need to quickly evacuate the clot from the brain. Craniotomy surgery and other minimally invasive methods using thrombolytic drugs are common procedures to remove the clot but are limited by factors such as morbidity and high susceptibility to rebleeding, which ultimately result in poor clinical outcomes.

Histotripsy is a non-thermal ultrasound ablation technique that uses short duration, high amplitude rarefactional pulses (>26 MPa) delivered via an extracorporeal transducer to generate targeted cavitation using the intrinsic gas nuclei existing in the target tissue. The rapid and energetic bubble expansion and collapse of cavitation create high stress and strain in tissue at the focus that fractionate it into an acellular homogenate. This dissertation presents the role of histotripsy as a novel ultrasound technology with potential to address the need for an effective transcranial therapy for ICH and other brain pathologies.

The first part of this work investigates the effects of ultrasound frequency and focal spacing on transcranial clot liquefaction using histotripsy. Histotripsy pulses were delivered using two 256-element hemispherical transducers of different frequency (250 and 500 kHz) with 30-cm aperture diameters. Liquefied clot was drained via catheter and syringe in the range of 6-59 mL in 0.9-42.4 min. The fastest rate was 16.6 mL/min. The best parameter combination was λ spacing at 500 kHz, which produced large liquefaction through 3 skullcaps (~30 mL) with fast rates (~2 mL/min). The temperature-rise through the 3 skullcaps remained below 4°C.

The second part addresses initial safety concerns for histotripsy ICH treatment through investigation in a porcine ICH model. 1.75-mL clots were formed in the frontal lobe of the brain. The centers of the clots were liquefied with histotripsy 48 h after formation, and the content was either evacuated or left within the brain. A control group was left untreated. Histotripsy was able to liquefy the core of clots without direct damage to the perihematomal brain tissue. An average volume of 0.9 ± 0.5 mL (~50%) was drained after histotripsy treatment. All groups showed mild ischemia and gliosis in the perihematomal region; however, there were no deaths or signs of neurological dysfunction in any groups.

The third part presents the development of a novel catheter hydrophone method for transcranial phase aberration correction and drainage of the clot liquefied with histotripsy. A prototype hydrophone was fabricated to fit within a ventriculostomy catheter. Improvements in focal pressure of up to 60% were achieved at the geometric focus and 27%-62% across a range of electronic steering locations. The sagittal and axial -6-dB beam widths decreased from 4.6 to 2.2 mm in the sagittal direction and 8 to 4.4 mm in the axial direction, compared to 1.5 and 3 mm in the absence of aberration. The cores of clots liquefied with histotripsy were readily drained via the catheter.

The fourth part focuses on the development of a preclinical system for translation to human cadaver ICH models. A 360-element, 700 kHz hemispherical array with a 30 cm aperture was designed and integrated with an optical tracker surgical navigation system. Calibrated simulations of the transducer suggest a therapeutic range between 48 – 105 mL through the human skull with the ability to apply therapy pulses at pulse-repetition-frequencies up to 200 Hz. The navigation system allows real-time targeting and placement of the catheter hydrophone via a pre-operative CT or MRI.

The fifth and final part of this work extends transcranial histotripsy therapy beyond ICH to the treatment of glioblastoma. This section presents results from an initial investigation into cancer immunomodulation using histotripsy in a mouse glioblastoma model. The results suggest histotripsy has some immunomodulatory capacity as evidenced by a 2-fold reduction in myeloid derived suppressor cells and large increases in interferon-γ concentrations (3500 pg/mL) within the brain tumors of mice treated with histotripsy.

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Lecture / Discussion Mon, 16 Mar 2020 13:26:52 -0400 2020-03-26T10:00:00-04:00 2020-03-26T11:00:00-04:00 Lurie Robert H. Engin. Ctr Biomedical Engineering Lecture / Discussion BME Logo
The Beattie Family Seminar Series in Combat Casualty Care (March 30, 2020 3:00pm) https://events.umich.edu/event/71949 71949-17903307@events.umich.edu Event Begins: Monday, March 30, 2020 3:00pm
Location: North Campus Research Complex Building 10
Organized By: Michigan Center for Integrative Research in Critical Care (MCIRCC)

Carol Ann Fausone graduated from the University of Michigan School of Nursing in 1975. General Fausone served her country for 36 years retiring in 2011. From 2003-2011 she served as the Assistant Adjutant General of Veterans Affairs, for the Department of Military and Veterans Affairs, State of Michigan advocating for Veterans. From 2001-2005, General Fausone served as the Assistant for Mobilization and Reserve Affairs working directly with the Deputy Assistant Secretary of Defense for Health Affairs, Force Health Protection and Readiness. Serving in this capacity, she assisted in developing and implementing programs, policy, and operations for Reserve Affairs.

Carol Ann continues serving by “Taking Care of Our American Heroes and their Families” to obtain the benefits they deserve at Legal Help for Veterans.

DETAILS & REGISTRATION:
http://bit.ly/CarolAnnFausone

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Workshop / Seminar Thu, 23 Jan 2020 12:01:20 -0500 2020-03-30T15:00:00-04:00 2020-03-30T16:00:00-04:00 North Campus Research Complex Building 10 Michigan Center for Integrative Research in Critical Care (MCIRCC) Workshop / Seminar The Beattie Family Seminar Series in Combat Casualty Care with Brigadier General Carol Ann Fausone (ret) Flyer
Safe Medication Disposal Event (April 7, 2020 10:00am) https://events.umich.edu/event/73145 73145-18147050@events.umich.edu Event Begins: Tuesday, April 7, 2020 10:00am
Location: Rackham Graduate School (Horace H.)
Organized By: U-M College of Pharmacy

Drop off your expired, old, or unused medications to be disposed of in an environmentally safe way! The University of Michigan Pharmacy students will operate two collection locations simultaneously, outside of Rackham Gradual School and the Brighton Center for Specialty Care.
*Drive Up + Drop Off Available*

Accepted Items: Prescription & OTC medications, medication samples, vitamins, ointments & lotions, inhalers, antibiotics, steroids, veterinary medicine, and
controlled medications. We now accept sharps and sharps containers!

For questions please contact the U-M College of Pharmacy at (734) 764-7312

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Community Service Thu, 20 Feb 2020 11:28:44 -0500 2020-04-07T10:00:00-04:00 2020-04-07T14:00:00-04:00 Rackham Graduate School (Horace H.) U-M College of Pharmacy Community Service Safe Medication Disposal Event
Bioethics Discussion: Responsibility (April 7, 2020 7:00pm) https://events.umich.edu/event/52730 52730-12974164@events.umich.edu Event Begins: Tuesday, April 7, 2020 7:00pm
Location: Off Campus Location
Organized By: The Bioethics Discussion Group

A discussion on what we owe to ourselves and others.

NOTICE: Online hosting procedure https://bluejeans.com/7569798571.

Readings to consider:
1. Social Responsibilities of Bioethics
2. The Concept of Responsibility: Three Stages in Its Evolution within Bioethics
3. Bioethics for Whom?
4. Towards an Ethics of Blame

For more information and/or to receive a copy of the readings contact Barry Belmont at belmont@umich.edu or visit http://belmont.bme.umich.edu/bioethics-discussion-group/discussions/044-responsibility/.

Please read the blog responsibly: https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Thu, 02 Apr 2020 09:12:34 -0400 2020-04-07T19:00:00-04:00 2020-04-07T20:30:00-04:00 Off Campus Location The Bioethics Discussion Group Lecture / Discussion Responsibility
CANCELLED: Health Professions Education Day (April 14, 2020 8:00am) https://events.umich.edu/event/70516 70516-17602797@events.umich.edu Event Begins: Tuesday, April 14, 2020 8:00am
Location: Michigan League
Organized By: Department of Learning Health Sciences

HPE Day 2020 Cancelled
Based on the University’s guidelines to cancel gatherings of over 100 people until at least April 21 due to the COVID-19 outbreak, we regret to announce that Health Professions Education Day 2020 is cancelled. The event was scheduled to take place on April 14, 2020.

We plan to create an online space where accepted posters can be captured and asynchronous discussion can take place. The details and logistics of this will await resumption of normal business activities. For those of you with accepted poster abstracts, this will include a new deadline for poster PDFs.

Your understanding and flexibility is appreciated. The safety of our faculty, staff, and students is our top priority.


The 6th Annual Health Professions Education Day will be held on Tuesday, April 14, 2020 from 8am - 3pm at the Michigan League. The guest lecturer will be Elena Umland, PharmD.

Agenda
7:30-8:00am: Poster Set-up
8:00-8:30am: Registration and Breakfast
8:30-8:45am: Welcome and Introduction
8:45-9:30am: Keynote Address from Elena Umland, PharmD
9:45-11:15am: Poster Sessions
11:15-11:45am: Awards and Closing Remarks
12:00-1:00pm: Table Topic Lunch
1:00-3:00pm: **Workshop**

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Conference / Symposium Mon, 16 Mar 2020 11:17:13 -0400 2020-04-14T08:00:00-04:00 2020-04-14T15:00:00-04:00 Michigan League Department of Learning Health Sciences Conference / Symposium Elena Umland pic
Bioethics Discussion: History (April 21, 2020 7:00pm) https://events.umich.edu/event/52731 52731-12974165@events.umich.edu Event Begins: Tuesday, April 21, 2020 7:00pm
Location: Off Campus Location
Organized By: The Bioethics Discussion Group

A discussion on the means to our ends.

NOTICE: Online hosting procedure https://bluejeans.com/7569798571.

Readings to consider:
1. Bioethics and History
2. The History of Bioethics: Its Rise and Significance
3. What can History do for Bioethics?
4. “My Story Is Broken; Can You Help Me Fix It?”: Medical Ethics and the Joint Construction of Narrative

For more information and/or to receive a copy of the readings contact Barry Belmont at belmont@umich.edu or visit http://belmont.bme.umich.edu/bioethics-discussion-group/discussions/045-history/.

Of historical note – the blog: https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Thu, 02 Apr 2020 09:22:43 -0400 2020-04-21T19:00:00-04:00 2020-04-21T20:30:00-04:00 Off Campus Location The Bioethics Discussion Group Lecture / Discussion History
COVID-19 - A New Update (April 24, 2020 10:00am) https://events.umich.edu/event/74393 74393-18682278@events.umich.edu Event Begins: Friday, April 24, 2020 10:00am
Location: Off Campus Location
Organized By: Osher Lifelong Learning Institute (50+)

Dr. Lona Mody, Amanda Sanford Hickey Professor Internal Medicine, Associate Division Chief of Geriatric and Palliative Care Medicine will give you the latest information on the COVID-19 Pandemic.

The link to Mody's lecture is:
https://primetime.bluejeans.com/a2m/live-event/vxujjpgq

To call in, dial: 1 (800) 520-9950 and enter PIN 1214384 #

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Lecture / Discussion Thu, 23 Apr 2020 17:26:05 -0400 2020-04-24T10:00:00-04:00 2020-04-24T11:30:00-04:00 Off Campus Location Osher Lifelong Learning Institute (50+) Lecture / Discussion Special Online Lectures
PhD Defense: Richard Youngblood (April 29, 2020 2:00pm) https://events.umich.edu/event/74358 74358-18666222@events.umich.edu Event Begins: Wednesday, April 29, 2020 2:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be held via Blue Jeans. The link will be posted below.

BlueJeans: https://bluejeans.com/855683101

Human pluripotent stem cells (hPSCs) differentiated into complex three-dimensional (3D) structures, referred to as ‘organoids’ due to their organ-like properties, offer ideal platforms to study human development, disease and regeneration. However, studying organ morphogenesis has been hindered by the lack of appropriate culture systems that can spatially enable cellular interactions that are needed for organ formation. Many organoid cultures rely on decellularized extracellular matrices as supportive scaffolds, which are often poorly chemically defined and allow only limited tunability and reproducibility. By contrast, engineered synthetic matrices can be tuned and optimized to mimic the embryo environment in order to enhance development and maturation of organoid cultures. Herein, this work primarily focuses on using synthetic polymer matrices to investigate how the design of biomaterials can guide key interactions guiding stem-cell decisions for the reproducible generation and control of organoid cultures.
Microporous biomaterials comprised of synthetic polymer materials were shown to guide the assembly of pancreatic progenitors into insulin-producing clusters that further developed into islet organoids. The scaffold culture facilitated cell-cell interactions enabled by the scaffold design and supported cell-mediated matrix deposition of extracellular matrix (ECM) proteins associated with the basement membrane of islet cells. Furthermore, when compared to suspension cultures, the scaffold culture showed increased insulin secretion in response to glucose stimulus indicating the development of functional β-cells. By modifying the stage that cells were seeded on scaffolds from pancreatic progenitor to pancreatic endoderm, islet organoids showed increased amounts of insulin secreted per cell. In addition, seeding scaffolds with dense clusters instead of a single suspension minimized cell manipulation during the differentiation, which was shown to be influential to the development of the islet organoids. An engineered insulin reporter further identified how mechanistic changes in vitro influenced function within individual cells by measuring insulin storage and secretion through non-invasive imaging.
hPSC-derived lung organoids (HLOs) were also evaluated for in vivo maturation on biomaterial scaffolds, where HLOs were shown improved tissue structure and cellular differentiation. Investigative studies demonstrated that scaffold pore interconnectivity and polymer degradation contributed to in vivo maturation, the size of the airway structures and the total size of the transplanted tissue. Polymer biomaterials were also developed to modulate local tissue and systemic inflammation through local delivery of human interleukin 4 (hIL-4)-expressing lentivirus. Microporous scaffold culture strategies improve organoid complexity and exert fine control over the system using engineering solutions, thus, allowing the community to build more realistic organoid tools. Taken together, the microporous scaffold culture demonstrates the feasibility to translate organoid culture to the clinic as a biomanufacturing platform.

Chair: Dr. Lonnie Shea

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Lecture / Discussion Tue, 21 Apr 2020 13:21:55 -0400 2020-04-29T14:00:00-04:00 2020-04-29T15:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Beautiful Boy (April 29, 2020 7:30pm) https://events.umich.edu/event/73660 73660-18278619@events.umich.edu Event Begins: Wednesday, April 29, 2020 7:30pm
Location: Off Campus Location
Organized By: UM Addiction Center

Please join us at 7:30pm on April 29 at the Michigan Theater for a screening of the film Beautiful Boy, followed by a Q&A with Joanna Quigley, M.D. and Sarah Rollins, LMSW, from the U-M Department of Psychiatry and U-M Addiction Treatment Services.

Based on the best-selling pair of memoirs from father and son David and Nic Sheff, Beautiful Boy chronicles the heartbreaking and inspiring experience of survival, relapse, and recovery in a family coping with addiction over many years. Starring Steve Carell, Timothée Chalamet, Maura Tierney and Amy Ryan. 2018. Drama. 121 min. R.

This event is hosted by the University of Michigan Addiction Center.

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Film Screening Fri, 06 Mar 2020 14:31:38 -0500 2020-04-29T19:30:00-04:00 2020-04-29T21:30:00-04:00 Off Campus Location UM Addiction Center Film Screening Beautiful Boy
The Public Health Crisis of American Gun Violence (May 4, 2020 5:30pm) https://events.umich.edu/event/70823 70823-17654654@events.umich.edu Event Begins: Monday, May 4, 2020 5:30pm
Location: Off Campus Location
Organized By: Osher Lifelong Learning Institute (50+)

Physicians for the Prevention of Gun Violence (PPGV) is a Michigan based organization that educates physicians on the prevention of gun violence. Approximately 100 Americans are shot to death each day and over twice as many are physically wounded. PPGV has been educating health professionals to talk to patients about access to guns, safe storage, and helping them make decisions that facilitate optimal health and safety. Recognizing that the majority of gun deaths are due to suicide, PPGV emphasizes the need to keep guns out of the hands of people with emotional, substance-related, or mental health crises. PPGV also advocates for the passage of sensible gun reform legislation. In this presentation, we will examine gun violence, focusing on how particular populations such as women, children, communities of color, and individuals struggling with mental health challenges are uniquely affected. We will examine the epidemiology of gun violence and outline some of the ways in which politics have become entangled with the pursuit of life-saving interventions. We will describe how non-medical community members can have a major impact in raising awareness by inquiring about safe storage of firearms. Instructor Sonya Lewis will lead our discussion of selected state and federal gun violence-related legislation and encourage attendees to contact elected leaders to advocate for bills to prevent gun violence. Finally, we will open the conversation to course attendees as we examine the historical challenges faced in addressing gun violence and discuss opportunities to effect meaningful change.

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Class / Instruction Wed, 25 Dec 2019 16:17:19 -0500 2020-05-04T17:30:00-04:00 2020-05-04T19:30:00-04:00 Off Campus Location Osher Lifelong Learning Institute (50+) Class / Instruction OLLI Study Group
PhD Defense: Xianglong Wang (May 5, 2020 1:00pm) https://events.umich.edu/event/74357 74357-18666221@events.umich.edu Event Begins: Tuesday, May 5, 2020 1:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be via Zoom. The link will be provided below.

Zoom: https://umich.zoom.us/j/99315883529

Biological transport processes often involve a boundary acting as separation of flow, most commonly in transport involving blood-contacting medical devices. The separation of flow creates two different scenarios of mass transport across the interface. No flow exists within the medical device and diffusion governs mass transport; both convection and diffusion exist when flow is present. The added convection creates a large concentration gradient around the interface. Computer simulation of such cases prove to be difficult and require proper shock capturing methods for the solutions to be stable, which is typically lacking in commercial solvers. In this talk, we propose a second-order accurate numerical method for solving the convection-diffusion equation by using a gradient-limited Godunov-type convective flux and the multi-point flux approximation (MPFA) L-Method for the diffusion flux. We applied our solver towards simulation of a nitric oxide-releasing intravascular catheter.

Intravascular catheters are essential for long-term vascular access in both diagnosis and treatment. Use of catheters are associated with risks for infection and thrombosis. Risk management dictates that the catheters to be often replaced on a 3 to 5-day cycle, which is bothersome to both patients and physicians. Nitric oxide (NO) is a potent antimicrobial and antithrombotic agent produced by vascular endothelial cells. The production level in vivo is so low that the physiological effects can only be seen around the endothelial cells. The catheter can incorporate a NO source in two major ways: by impregnating the catheter with NO-releasing compounds such as S-nitroso-N-acetyl penicillamine (SNAP) or using electrochemical reactions to generate NO from nitrites. We applied our solver to both situations to guide the design of the catheter.

Lung edema is often present in patients with end-stage renal disease due to reduced filtration functions of the kidney. These patients require regular dialysis sessions to manage their fluid status. The clinical gold standard to quantify lung edema is to use CT, which exposes patients to high amounts of radiation and is not cost efficient. Fluid management in such patients becomes very challenging without a clear guideline of fluid to be removed during dialysis sessions. Aggressive fluid removal can cause both exacerbations of congestive failure and hypotension resulting from low blood volume.

Recently, reverberations in ultrasound signals, referred to as “lung ultrasound comets” have emerged as a potential quantitative way to measure lung edema. Increased presence of lung comets is associated with higher amounts of pulmonary edema, higher mortality, and more adverse cardiac events. However, the lung comets are often counted by hand by physicians with single frames in lung ultrasound and high subjectivity has been found to exist among the counting by physicians. We applied image processing and neural network techniques as an attempt to provide an objective and accurate measurement of the amount of lung comets present. Our quantitative results are significantly correlated with a few clinical parameters, including diastolic blood pressure and ejection fraction.

Co-Chairs: Dr. Joseph Bull and Dr. Alberto Figueroa

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Lecture / Discussion Tue, 21 Apr 2020 13:16:12 -0400 2020-05-05T13:00:00-04:00 2020-05-05T14:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
RNA Center Journal Club - The architecture of SARS-CoV-2 transcriptome (May 7, 2020 4:00pm) https://events.umich.edu/event/74371 74371-18674250@events.umich.edu Event Begins: Thursday, May 7, 2020 4:00pm
Location:
Organized By: Center for RNA Biomedicine

Link to publication: https://www.cell.com/pb-assets/products/coronavirus/CELL_CELL-D-20-00765.pdf

Link to Zoom meeting: https://umich.zoom.us/j/97186405854

The RNA Journal Club meets to prepare for seminars and engage with their presenters. The Club studies and reviews the articles relating to upcoming talks. It discusses the theory, methodology and findings of a publication to develop questions for its author.

The Club meets monthly and is open to all. The Journal Club meetings are announced here https://rna.umich.edu/events/. Graduate students and post-docs in RNA research are strongly encouraged to participate. The diversity of expertise within the Club makes it particularly engaging as different perspectives are being exchanged.

The Journal Club is organized by the RNA Student & PostDoc Council. The objective of the RNA Student & PostDoc Council is to work collaboratively across disciplines, build a community and generate innovative ideas to advance RNA research and education across the University of Michigan.

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Livestream / Virtual Thu, 07 May 2020 11:47:34 -0400 2020-05-07T16:00:00-04:00 2020-05-07T17:00:00-04:00 Center for RNA Biomedicine Livestream / Virtual logo
Perspectives on the social dimensions of infectious crises (pandemics and epidemics), and the specific role of vaccines. (May 11, 2020 10:15am) https://events.umich.edu/event/74520 74520-18776714@events.umich.edu Event Begins: Monday, May 11, 2020 10:15am
Location: Off Campus Location
Organized By: Osher Lifelong Learning Institute (50+)

Vaccines are the topic of the first Lecture Video Learning developed for OLLI members. Lecture Video Learning will include videos that give background perspective combined with live presentations that offer timely updates.

Online - Free! No registration needed.
https://umich.zoom.us/j/92098972759.

Presenter Dr. Alexandra Stern is the Zina Pitcher Collegiate Professor in the History of Medicine and associate director of the Center for the History of Medicine. She is a medical historian with a research focus on the 1918 influenza pandemic in the United States. Her expertise supplies historical context in such areas as public health, children’s health, scapegoating, ethnic relations, political governance and social restrictions, and the complex interplay among these elements that define the human and community experience during an evolving public health emergency.

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Lecture / Discussion Tue, 05 May 2020 10:40:23 -0400 2020-05-11T10:15:00-04:00 2020-05-11T12:15:00-04:00 Off Campus Location Osher Lifelong Learning Institute (50+) Lecture / Discussion Video Lecture
"Let's Go To The Movies", a Fundraiser for Michigan Medicine's Employee Relief Fund (May 15, 2020 8:00pm) https://events.umich.edu/event/74597 74597-18849158@events.umich.edu Event Begins: Friday, May 15, 2020 8:00pm
Location:
Organized By: University Charity Events

Join Boylesque Drag for a virtual performance on Friday, May 15 at 8 p.m. Just $10 will get you the link (plus any donation you want to add) for two hours worth of fun drag performances, all proceeds of which go to the Michigan Medicine Employee Relief Fund. To get your link go to
--Venmo: @RileyJSironen
--PayPal: r.sironen@yahoo.com
--CashApp: $RileySironen

For more information contact jadeinblack@yahoo.com

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Livestream / Virtual Thu, 14 May 2020 08:30:31 -0400 2020-05-15T20:00:00-04:00 2020-05-15T22:00:00-04:00 University Charity Events Livestream / Virtual Event flyer
Economy, Policy, and Political Approaches to Vaccines (May 18, 2020 2:00pm) https://events.umich.edu/event/74522 74522-18776715@events.umich.edu Event Begins: Monday, May 18, 2020 2:00pm
Location: Off Campus Location
Organized By: Osher Lifelong Learning Institute (50+)

Vaccines are the topic of the first Lecture Video Learning developed for OLLI members. Lecture Video Learning will include videos that give background perspective combined with live presentations that offer timely updates.

Online - Free! No registration needed.
https://umich.zoom.us/j/92098972759

Topic 1 (2:00-3:00): Economic and policy approaches to vaccines: modeling of infectious diseases at the CDC and other organizations for guidance to policy makers and the public; leadership in political eras of low trust.

Dr. David Hutton is an expert in health policy modeling and medical decision making, and has had a nationally recognized influence on national and international hepatitis B policy. He is currently interested in evaluating the cost-effectiveness of: new public health policies, the use of new drugs and devices, chronic and infectious disease interventions, and interventions with uncertain or complex outcomes.

Topic 2 (3:00-4:00): The appropriate role of government in vaccines: power dynamics, priorities, jurisdictions; funding of critical health system infrastructure and preparedness.

Dr. Abdul El-Sayed is a physician, epidemiologist, public health expert, and progressive activist. In 2018, Abdul ran for Governor of Michigan on an unapologetically progressive platform. Prior, he served as Health Commissioner in the City of Detroit, appointed to rebuild the City’s health department after it was privatized during municipal bankruptcy. As a professor at Columbia University's Department of Epidemiology, Abdul became an internationally recognized expert in health policy and health inequalities.

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Class / Instruction Tue, 05 May 2020 11:01:19 -0400 2020-05-18T14:00:00-04:00 2020-05-18T16:00:00-04:00 Off Campus Location Osher Lifelong Learning Institute (50+) Class / Instruction Lecture Video Learning
The Epidemiology of Pandemics and Vaccines (May 26, 2020 10:00am) https://events.umich.edu/event/74562 74562-18825097@events.umich.edu Event Begins: Tuesday, May 26, 2020 10:00am
Location: Off Campus Location
Organized By: Osher Lifelong Learning Institute (50+)

This event is free and available to the public. OLLI membership is not required.

The epidemiology of pandemics and vaccines: the history and process of vaccine development in the US and globally; rapid response to produce a covid-19 vaccine, and near-term drug and antibody therapies

Speaker Dr. Emily Toth Martin is on the faculty of Epidemiology at the University of Michigan School of Public Health. Her research focuses on building a greater understanding of the epidemiology of viral respiratory diseases (including RSV, bocavirus, and influenza) through the use of molecular epidemiology. In particular, her work aims to identify strategies to reduce infections, particularly in individuals with chronic comorbidities and in hospital infectious environments (including MRSA / VRE coinfection).

Online - Free! No registration needed. Link to the 3 sessions: Please use the following link to access the event:
https://umich.zoom.us/j/92098972759

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Lecture / Discussion Mon, 11 May 2020 08:27:08 -0400 2020-05-26T10:00:00-04:00 2020-05-26T11:30:00-04:00 Off Campus Location Osher Lifelong Learning Institute (50+) Lecture / Discussion Special Online Lectures
Webinar: Learning Health Systems in the Time of COVID-19 (June 2, 2020 2:00pm) https://events.umich.edu/event/74564 74564-18825099@events.umich.edu Event Begins: Tuesday, June 2, 2020 2:00pm
Location:
Organized By: Department of Learning Health Sciences

This 90-minute webinar is designed to introduce individuals to the overall concept of learning health systems, focusing on core components of learning cycles and infrastructure. It is appropriate for anyone interested in how health systems function, and particularly for individuals working within health systems. We will use examples that span countries and clinical problems, with special emphasis on the SARS-CoV-2 pandemic.

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Lecture / Discussion Mon, 11 May 2020 11:05:21 -0400 2020-06-02T14:00:00-04:00 2020-06-02T15:30:00-04:00 Department of Learning Health Sciences Lecture / Discussion Corona virus and Collaboratory logo
Using Precision Health resources to empower your COVID-19 research (June 25, 2020 10:30am) https://events.umich.edu/event/74897 74897-19065439@events.umich.edu Event Begins: Thursday, June 25, 2020 10:30am
Location: Off Campus Location
Organized By: Precision Health

How to use Precision Health resources (MGI and more) to empower your COVID-19 research


COVID-19 is the most urgent health crisis of our generation, and we will be studying it for decades to come. Join us for a one-hour workshop to explore:
• Data available on coronavirus testing and diagnoses
• Data available on demographics, comorbidities, medications, and other clinical information related to health outcomes
• Data available on genotypes for >70,000-participant MGI cohort
• Tools and services available to you for accessing and analyzing data

The workshop will be led by Erin O’Brien Kaleba, MPH, Director, Data Office for Clinical & Translational Research.

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Livestream / Virtual Wed, 10 Jun 2020 13:32:07 -0400 2020-06-25T10:30:00-04:00 2020-06-25T11:30:00-04:00 Off Campus Location Precision Health Livestream / Virtual Empower your research with PH resources
BioArtography Virtual Art Fair Sale through July 21! (July 16, 2020 12:00am) https://events.umich.edu/event/75240 75240-19342129@events.umich.edu Event Begins: Thursday, July 16, 2020 12:00am
Location: Off Campus Location
Organized By: BioArtography

BioArtography is having a Virtual Art Fair through July 21! An exciting collection of new images for 2020 will be launched & returning favorites are still available!

Specials will be offered on our website bioartography.com including 15% off and free U.S. shipping on note cards, prints, framed art, gallery wrap canvas and frameless glass!

Follow @bioartography on Twitter , Instagram and Facebook to keep up with all the details!

Proceeds from the sale of this work help support the training of our next generation of researchers!

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Exhibition Mon, 20 Jul 2020 12:13:02 -0400 2020-07-16T00:00:00-04:00 2020-07-16T23:59:00-04:00 Off Campus Location BioArtography Exhibition BioArtography 2020 Collection
BioArtography Virtual Art Fair Sale through July 21! (July 17, 2020 12:00am) https://events.umich.edu/event/75240 75240-19342130@events.umich.edu Event Begins: Friday, July 17, 2020 12:00am
Location: Off Campus Location
Organized By: BioArtography

BioArtography is having a Virtual Art Fair through July 21! An exciting collection of new images for 2020 will be launched & returning favorites are still available!

Specials will be offered on our website bioartography.com including 15% off and free U.S. shipping on note cards, prints, framed art, gallery wrap canvas and frameless glass!

Follow @bioartography on Twitter , Instagram and Facebook to keep up with all the details!

Proceeds from the sale of this work help support the training of our next generation of researchers!

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Exhibition Mon, 20 Jul 2020 12:13:02 -0400 2020-07-17T00:00:00-04:00 2020-07-17T23:59:00-04:00 Off Campus Location BioArtography Exhibition BioArtography 2020 Collection
BioArtography Virtual Art Fair Sale through July 21! (July 18, 2020 12:00am) https://events.umich.edu/event/75240 75240-19342131@events.umich.edu Event Begins: Saturday, July 18, 2020 12:00am
Location: Off Campus Location
Organized By: BioArtography

BioArtography is having a Virtual Art Fair through July 21! An exciting collection of new images for 2020 will be launched & returning favorites are still available!

Specials will be offered on our website bioartography.com including 15% off and free U.S. shipping on note cards, prints, framed art, gallery wrap canvas and frameless glass!

Follow @bioartography on Twitter , Instagram and Facebook to keep up with all the details!

Proceeds from the sale of this work help support the training of our next generation of researchers!

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Exhibition Mon, 20 Jul 2020 12:13:02 -0400 2020-07-18T00:00:00-04:00 2020-07-18T23:59:00-04:00 Off Campus Location BioArtography Exhibition BioArtography 2020 Collection
BioArtography Virtual Art Fair Sale through July 21! (July 19, 2020 12:00am) https://events.umich.edu/event/75240 75240-19342132@events.umich.edu Event Begins: Sunday, July 19, 2020 12:00am
Location: Off Campus Location
Organized By: BioArtography

BioArtography is having a Virtual Art Fair through July 21! An exciting collection of new images for 2020 will be launched & returning favorites are still available!

Specials will be offered on our website bioartography.com including 15% off and free U.S. shipping on note cards, prints, framed art, gallery wrap canvas and frameless glass!

Follow @bioartography on Twitter , Instagram and Facebook to keep up with all the details!

Proceeds from the sale of this work help support the training of our next generation of researchers!

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Exhibition Mon, 20 Jul 2020 12:13:02 -0400 2020-07-19T00:00:00-04:00 2020-07-19T23:59:00-04:00 Off Campus Location BioArtography Exhibition BioArtography 2020 Collection
BioArtography Virtual Art Fair Sale through July 21! (July 20, 2020 12:00am) https://events.umich.edu/event/75240 75240-19379434@events.umich.edu Event Begins: Monday, July 20, 2020 12:00am
Location:
Organized By: BioArtography

BioArtography is having a Virtual Art Fair through July 21! An exciting collection of new images for 2020 will be launched & returning favorites are still available!

Specials will be offered on our website bioartography.com including 15% off and free U.S. shipping on note cards, prints, framed art, gallery wrap canvas and frameless glass!

Follow @bioartography on Twitter , Instagram and Facebook to keep up with all the details!

Proceeds from the sale of this work help support the training of our next generation of researchers!

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Exhibition Mon, 20 Jul 2020 12:13:02 -0400 2020-07-20T00:00:00-04:00 2020-07-20T23:59:00-04:00 BioArtography Exhibition BioArtography 2020 Collection
Philip S. Brachman Memorial Lecture (July 20, 2020 2:00pm) https://events.umich.edu/event/75242 75242-19379439@events.umich.edu Event Begins: Monday, July 20, 2020 2:00pm
Location:
Organized By: School of Public Health

Wednesday, July 22 at 12:15 p.m.
Topic: Triangulating Evidence from Different Methods to Improve Causal Understanding
https://umich.zoom.us/j/99552023212

Join from a PC, Mac, iPad, iPhone or Android device:
Please click this URL to join. https://umich.zoom.us/j/99552023212
Password: 354712
Description: Wednesday, July 22 at 12:15 p.m.

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Conference / Symposium Mon, 20 Jul 2020 14:18:20 -0400 2020-07-20T14:00:00-04:00 2020-07-20T15:00:00-04:00 School of Public Health Conference / Symposium Brachman Lecture
BioArtography Virtual Art Fair Sale through July 21! (July 21, 2020 12:00am) https://events.umich.edu/event/75240 75240-19379435@events.umich.edu Event Begins: Tuesday, July 21, 2020 12:00am
Location:
Organized By: BioArtography

BioArtography is having a Virtual Art Fair through July 21! An exciting collection of new images for 2020 will be launched & returning favorites are still available!

Specials will be offered on our website bioartography.com including 15% off and free U.S. shipping on note cards, prints, framed art, gallery wrap canvas and frameless glass!

Follow @bioartography on Twitter , Instagram and Facebook to keep up with all the details!

Proceeds from the sale of this work help support the training of our next generation of researchers!

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Exhibition Mon, 20 Jul 2020 12:13:02 -0400 2020-07-21T00:00:00-04:00 2020-07-21T23:59:00-04:00 BioArtography Exhibition BioArtography 2020 Collection
Philip S. Brachman Memorial Lecture (July 22, 2020 12:15pm) https://events.umich.edu/event/75242 75242-19348012@events.umich.edu Event Begins: Wednesday, July 22, 2020 12:15pm
Location:
Organized By: School of Public Health

Wednesday, July 22 at 12:15 p.m.
Topic: Triangulating Evidence from Different Methods to Improve Causal Understanding
https://umich.zoom.us/j/99552023212

Join from a PC, Mac, iPad, iPhone or Android device:
Please click this URL to join. https://umich.zoom.us/j/99552023212
Password: 354712
Description: Wednesday, July 22 at 12:15 p.m.

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Conference / Symposium Mon, 20 Jul 2020 14:18:20 -0400 2020-07-22T12:15:00-04:00 2020-07-22T13:30:00-04:00 School of Public Health Conference / Symposium Brachman Lecture
PhD Defense: Katy Norman (July 30, 2020 10:00am) https://events.umich.edu/event/75267 75267-19395124@events.umich.edu Event Begins: Thursday, July 30, 2020 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be held via BlueJeans. The link will be posted below.

BlueJeans: https://bluejeans.com/516255948

Mucosal surfaces in the lung interface with the outside environment for breathing purposes, but also provide the first line of defense against invading pathogens. The intricate balance of effective immune protection at the pulmonary epithelium without problematic inflammation is not well understood, but is an important consideration in complex lung diseases such as idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD). Although IPF is a fibrotic interstitial lung disease of unknown origin and COPD is an obstructive lung disease, they do share some similarities. Both are heterogeneous and progressive in nature, have no cure and few treatment options, advance through unknown mechanisms, and involve an aberrant immune response. As research has focused into the role the immune system plays in IPF and COPD, it has become clear that disease progression is caused by a complex dysregulation of immune factors and cells across the tissue compartments of the lungs and blood.

Data-driven modeling approaches offer the opportunity to infer protein interaction networks, which are able to identify diagnostic and prognostic biomarkers and also serve as the basis for new insight into systems-level mechanisms that define a disease state. Additionally, these approaches are able to integrate data from across multiple tissue compartments, allowing for a more holistic picture of a disease to be formed. Here, we have applied data-driven modeling approaches including partial least squares discriminant analysis, principal component analysis, decision tree analysis, and hierarchical clustering to high-throughput cell and cytokine measurements from human blood and lung samples to gain systems-level insight into IPF and COPD.

Overall we found that these approaches were useful for identifying signatures of proteins that differentiated disease state and progression better than current classifiers. We also found that integrating protein and cell measurements across tissue compartments generally improved classification and was useful for generating new mechanistic insight into progression and exacerbation events. In evaluating IPF progression, we showed that the blood proteome of progressors, but not of non-progressors, changes over time, and that our data-driven modeling techniques were able to capture these changes. Curiously, our models showed that complement system components may be associated with both COPD and IPF disease progression. Lastly, though our analysis suggested that circulating blood cytokines were not useful for differentiating disease state or progression, preliminary work suggested that cell-cell communication networks arising from stimulated peripheral blood proteins may be more useful for classification and gaining mechanistic insight from minimally invasive blood samples. Overall, we believe that this approach will be useful for studying the mucosal immune response present in other diseases that are also progressive or heterogeneous in nature.

Chair: Dr. Kelly Arnold

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Lecture / Discussion Wed, 22 Jul 2020 16:19:44 -0400 2020-07-30T10:00:00-04:00 2020-07-30T11:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
PhD Defense: Josiah Simeth (August 5, 2020 2:00pm) https://events.umich.edu/event/75278 75278-19402991@events.umich.edu Event Begins: Wednesday, August 5, 2020 2:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Notice: This event will be held via BlueJeans. The link will be placed below.

BlueJeans: https://bluejeans.com/715371816

Measures of regional and global liver function are critical in guiding treatments for intrahepatic cancers, and liver function is a dominant factor in the survival of patients with hepatocellular carcinoma (HCC). Global and regional liver function assessments are important for defining the magnitude and spatial distribution of radiation dose to preserve functional liver parenchyma and reduce incidence of hepatotoxicity from radiation therapy (RT) for intrahepatic cancer treatment. This individualized liver function-guided RT strategy is critical for patients with heterogeneous and poor liver function, often observed in cirrhotic patients treated for HCC. Dynamic gadoxetic-acid enhanced (DGAE) magnetic resonance imaging (MRI) allows investigation of liver function through observation of the uptake of contrast agent into the hepatocytes.

This work seeks to determine if gadoxetic uptake rate can be used as a reliable measure of liver function, and to develop robust methods for uptake estimation with an interest in the therapeutic application of this knowledge in the case of intrahepatic cancers. Since voxel-by voxel fitting of the preexisting nonlinear dual-input two-compartment model is highly susceptible to over fitting, and highly dependent on data that is both temporally very well characterized and low in noise, this work proposes and validates a new model for quantifying the voxel-wise uptake rate of gadoxetic acid as a measure of regional liver function. This linearized single-input two-compartment (LSITC) model is a linearization of the pre-existing dual-input model but is designed to perform uptake quantification in a more robust, computationally simpler, and much faster manner. The method is validated against the preexisting dual-input model for both real and simulated data. Simulations are used to investigate the effects of noise as well as issues related to the sampling of the arterial peak in the characteristic input functions of DGAE MRI.

Further validation explores the relationship between gadoxetic acid uptake rate and two well established global measures of liver function, namely: Indocyanine Green retention (ICGR) and Albumin-Bilirubin (ALBI) score. This work also establishes the relationships between these scores and imaging derived measures of whole liver function using uptake rate. Additionally, the same comparisons are performed for portal venous perfusion, a pharmacokinetic parameter that has been observed to correlate with function, and has been used as a guide for individualized liver function-guided RT. For the patients assessed, gadoxetic acid uptake rate performs significantly better as a predictor of whole liver function than portal venous perfusion.
This work also investigates the possible gains that could be introduced through use of gadoxetic uptake rate maps in the creation of function-guided RT plans. To this end, plans were created using both perfusion and uptake, and both were compared to plans that did not use functional guidance. While the plans were generally broadly similar, significant differences were observed in patients with severely compromised uptake that did not correspond with compromised perfusion.

This dissertation also deals with the problem of quantifying uptake rate in suboptimal very temporally sparse or short DGAE MRI acquisitions. In addition to testing the limits of the LSITC model for these limited datasets (both realistic and extreme), a neural network-based approach to quantification of uptake rate is developed, allowing for increased robustness over current models.

Chair: Dr. Yue Cao

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Lecture / Discussion Thu, 23 Jul 2020 17:51:41 -0400 2020-08-05T14:00:00-04:00 2020-08-05T15:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
A Simulation Based Comparison of Point-of-Care Testing and Central Laboratory Testing (August 31, 2020 4:30pm) https://events.umich.edu/event/76322 76322-19687515@events.umich.edu Event Begins: Monday, August 31, 2020 4:30pm
Location: Off Campus Location
Organized By: Center for Healthcare Engineering & Patient Safety (CHEPS)

In response to demand for fast and efficient clinical testing, the use of point-of-care testing (POCT) has become increasingly common in the United States. However, studies of POCT implementation have found that adopting POCT may not always be advantageous relative to centralized laboratory testing. We construct a simulation model of patient flow in an outpatient care setting to evaluate tradeoffs involved in POCT implementation across multiple dimensions, comparing measures of patient outcomes in varying clinical scenarios, testing regimes, and patient conditions. We find that POCT can significantly reduce clinical time for patients, as compared to traditional testing regimes, in settings where clinic and central testing areas are far apart. However, as distance from clinic to central testing area decreased, POCT advantage over central laboratory testing also decreased, in terms of time in the clinical system and estimated subsequent productivity loss. For example, testing for pneumonia resulted in an estimated average of 27.80 (central lab) versus 15.50 (POCT) total lost productive hours in a rural scenario, and an average of 14.92 (central lab) versus 15.50 (POCT) hours in a hospital-based scenario. Our results show that POCT can effectively reduce the average time a patient spends in the system for varying condition profiles and clinical scenarios. However, the number of total lost productive hours, a more holistic measure, is greatly affected by testing quality, where POCT often is at a disadvantage. Thus, it is important to consider factors such as clinical setting, target condition, testing costs, and test quality when selecting appropriate testing regime.

Vikrant Vaze is the Stata Family Career Development Associate Professor at Thayer School of Engineering at Dartmouth College. He is interested in developing optimization, game theory, and analytics approaches for improving large-scale complex systems, such as transportation and healthcare. In June 2020, Vikrant was selected as one of 85 engineers who will participate in the National Academy of Engineering’s 2020 US Frontiers of Engineering (NAE) Symposium. He holds two master’s degrees and a Ph.D. from the Massachusetts Institute of Technology in transportation and operations research, and a bachelor’s degree in civil engineering from the Indian Institute of Technology in Mumbai. Before joining academia, he worked as a Research Scientist in Philips Research and as an algorithmic trader on the Wall Street. Joint research work by Vikrant, his students and collaborators has been honored with best paper awards from AGIFORS in 2010, 2017, and 2019, from FAA/Eurocontrol in 2011 and 2017, and most recently with the INFORMS TSL Outstanding Paper Award in Air Transportation. He is the recipient of a number of academic and research honors including the Faculty Early Career Development Program (CAREER) Award from the U.S. National Science Foundation, as well as awards from the U.S. Department of Defense, Federal Aviation Administration, National Institutes of Health, World Wildlife Fund, and several other industry-sponsored awards.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach. For the Zoom link and password and to be added to the weekly e-mail for the series, please RSVP. For additional questions, contact CHEPSseminar@umich.edu. Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Fri, 28 Aug 2020 14:21:43 -0400 2020-08-31T16:30:00-04:00 2020-08-31T17:30:00-04:00 Off Campus Location Center for Healthcare Engineering & Patient Safety (CHEPS) Lecture / Discussion Vikrant Vaze, Ph.D.
DCMB / CCMB Weekly Seminar Series (September 9, 2020 4:00pm) https://events.umich.edu/event/76946 76946-19780535@events.umich.edu Event Begins: Wednesday, September 9, 2020 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract: Birth defects that interfere with craniofacial development can result in cognitive, neurosensory, and neuroendocrine defects that create life-long burdens for care. The forebrain, midbrain, hindbrain, five facial prominences, and pituitary gland develop between the first and second month of gestation in humans. Genetic defects that disrupt these processes cause a spectrum of disorders that range from holoprosencephaly (HPE) and septo-optic dysplasia (SOD) to pituitary hormone deficiencies. We screened a large cohort of Argentinean patients with congenital hypopituitarism and related disorders for mutations in known genes and identified novel pathogenic variants and examples of digenic disease. However, the majority of patients did not receive a molecular diagnosis, indicating the high degree of genetic complexity underlying these disorders and the need for additional gene discovery. The majority of known hypopituitarism genes were discovered through basic research in pituitary cell lines and mutant mice. To identify novel regulatory genes for pituitary organogenesis we analyzed differential binding of a key pituitary-specific transcription factor, POU1F1, in cell lines that represent pituitary progenitors and differentiated cells. We discovered that POU1F1 binding is associated with bZIP transcription factors in progenitors and with bHLH factors in differentiated cells. We also applied single cell RNA sequencing technology to analyze gene expression during pituitary organogenesis and discovered novel transcription factors that are candidates for driving cell specification as well as unique, rare cell types that are likely differentiation intermediates. Bioinformatic analyses have played key roles in advancing our knowledge of neuroendocrine birth defects and normal pituitary organogenesis.

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Lecture / Discussion Wed, 09 Sep 2020 08:26:42 -0400 2020-09-09T16:00:00-04:00 2020-09-09T17:00:00-04:00 Off Campus Location DCMB Seminar Series Lecture / Discussion Sally Camper, Ph.D., Margery Shaw Distinguished University Professor of Human Genetics, Professor of Internal Medicine, University of Michigan
RNA Collaborative Seminar featuring: Sue Hammoud, Human Genetics & Justin Colacino, Environmental Health Sciences (September 9, 2020 4:00pm) https://events.umich.edu/event/75865 75865-19615931@events.umich.edu Event Begins: Wednesday, September 9, 2020 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

ZOOM REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_GjVNcoWtRG6OkzxSDmfb8A

"Same Same Different: Single cell RNAseq identifies conserved and divergent features of mammalian spermatogenesis"
Sue Hammoud, Ph.D.
Assistant Professor of Human Genetics
Website: https://hammoud.lab.medicine.umich.edu/

~and~

"Single cell transcriptomic profiling to understand breast stem cell heterogeneity in development and cancer disparities"
Justin Colacino. Ph.D.
Assistant Professor of Environmental Health Sciences
Website: https://www.colacinolab.com/

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Lecture / Discussion Wed, 26 Aug 2020 11:44:32 -0400 2020-09-09T16:00:00-04:00 2020-09-09T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion RNA Collaborative
Identifying Emergency Funds and How to Advocate for Making Room in Your Financial Aid Package (September 11, 2020 2:00pm) https://events.umich.edu/event/75507 75507-19513173@events.umich.edu Event Begins: Friday, September 11, 2020 2:00pm
Location: Off Campus Location
Organized By: CEW+

Advance registration is required; look for the Zoom link at the bottom of your confirmation email after registering.

This session will provide information about how you can seek emergency funds should you experience an emergency situation or one-time, unusual, unforeseen expense while in school. Information about the types of situations that qualify for emergency funds and where to seek funding will be covered during this presentation.

RSVP HERE: http://www.cew.umich.edu/events/identifying-emergency-funds-and-how-to-advocate-for-making-room-in-your-financial-aid-package

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Livestream / Virtual Tue, 18 Aug 2020 14:02:34 -0400 2020-09-11T14:00:00-04:00 2020-09-11T15:00:00-04:00 Off Campus Location CEW+ Livestream / Virtual A jar of spilled change
LHS Collaboratory Seminar Series Virtual Kick-Off: Academic Medical Centers as Learning Health Systems (September 17, 2020 9:00am) https://events.umich.edu/event/75856 75856-19615923@events.umich.edu Event Begins: Thursday, September 17, 2020 9:00am
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Learning Health Systems (LHS) methods are now being implemented in interesting and varying ways by academic health centers and their clinical and translational science institutes across the country.
According to the Agency for Healthcare Research and Quality (AHRQ), the following are key attributes of Learning Health
Systems:

• Having leaders who are committed to a culture of continuous learning and improvement
• Systematically gathering and applying evidence in real-time to guide care
• Employing IT methods to share new evidence with clinicians to improve decision-making
• Promoting the inclusion of patients as vital members of the learning team
• Capturing and analyzing data and care experiences to improve care
• Continually assessing outcomes, refining processes and training to create a feedback cycle for learning and improvement

The LHS Collaboratory's fall seminar series virtual kick-off event will showcase the LHS experiences of three research-intensive academic centers that have been promoting LHS methods. We will be joined by distinguished senior colleagues from Duke,Vanderbilt, and Washington University, who will describe and discuss their institutions' work in this area. They will discuss strategies employed, investments made, challenges encountered, and successes achieved.

Panelists:
Kevin B. Johnson, MD, MS, FAAP, FACMI, Vanderbilt University
Christopher J. Lindsell, PhD, Vanderbilt University
Philip Payne, PhD, FACMI, Washington University
Michael Pencina, PhD, Duke University
Eric G. Poon, MD, MPH, Duke University

Discussant:
Carol R. Bradford, MD, MS, Executive Vice Dean for Academic Affairs, University of Michigan Medical School, Chief Academic Officer, Michigan Medicine, Professor of Otolaryngology-Head and Neck Surgery

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Lecture / Discussion Thu, 20 Aug 2020 09:45:31 -0400 2020-09-17T09:00:00-04:00 2020-09-17T11:00:00-04:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion LHS Collaboratory Logo-blocks
DCMB / CCMB Weekly Virtual Seminar featuring Gioele La Manno, Ph.D. (EPFL Life Sciences Early Independent Research Scholar (ELISIR) (September 18, 2020 12:00pm) https://events.umich.edu/event/77057 77057-19836073@events.umich.edu Event Begins: Friday, September 18, 2020 12:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

I will present our comprehensive single-cell transcriptome atlas of mouse brain development spanning from gastrulation to birth. In this atlasing effort, we identified almost a thousand distinct cellular states, including the initial emergence of the neuroepithelium, different glioblasts, and a rich set of region-specific secondary organizers that we localize spatially. In this context, I will provide an example of how the spatially-resolved transcriptomic data can be particularly useful to interpret the complexity of such complex atlases.

Continuing in this direction, I will show the approach that we recently proposed as a general way to spatially resolve different types of next-generation sequencing data. We designed an imaging-free framework to localize high throughput readouts within a tissue by combining compressive sampling and image reconstruction. Our first implementation of this framework transformed a low-input RNA sequencing protocol into an imaging-free spatial transcriptomics technique (STRP-seq).

Finally, I will showcase the technique with the profiling of the brain of the Australian bearded dragon Pogona vitticeps. With this analysis, we revealed the molecular anatomy of the telencephalon of this lizard and provided evidence for a marked regionalization of the reptilian pallium and subpallium.

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Lecture / Discussion Wed, 16 Sep 2020 11:27:53 -0400 2020-09-18T12:00:00-04:00 2020-09-18T13:00:00-04:00 Off Campus Location DCMB Seminar Series Lecture / Discussion Gioele La Manno, Ph.D. (EPFL Life Sciences Early Independent Research Scholar (ELISIR) École polytechnique fédérale de Lausanne ‐ EPFL Swiss Federal Institute of Technology Lausanne)
CHEPS Alums and their Experience Fighting COVID-19 (September 21, 2020 4:30pm) https://events.umich.edu/event/77491 77491-19875789@events.umich.edu Event Begins: Monday, September 21, 2020 4:30pm
Location:
Organized By: Center for Healthcare Engineering & Patient Safety (CHEPS)

As the COVID-19 pandemic became widespread, health systems had to adjust and problem-solve rapidly. On this panel, alumni of the Center for Healthcare Engineering and Patient Safety will discuss how they and their institutions responded to COVID-19 and worked to address new operational challenges while keeping patients and healthcare workers safe.

Joe East is Director of Patient Flow at Maine Medical Center where he is using systems engineering to improve patient care. He holds an MHSA in Health Care Administration/Management and an MSE in Industrial and Operations Engineering with a concentration in Healthcare Engineering and Patient Safety from the University of Michigan. In his time at Maine Medical he has improved discharge and patient placement processes, worked on nurse staffing models, and created actionable dashboards and reports.

Pamela Martinez is a Process Engineer and Project Manager for the UCHealth CARE Innovation Center. She holds an MSE in Industrial and Operations Engineering from the University of Michigan with a concentration in Healthcare Engineering and Patient Safety. Pam’s focus is to improve the efficiency, safety, and quality of healthcare delivery through Industrial and Systems Engineering principles.

Bill Zhang is Director of Hospital and Procedural Services at Kaiser Permanente. He holds an MPH in Health Care Administration/Management and an MSE in Industrial and Operations Engineering with a concentration in Healthcare Engineering and Patient Safety from the University of Michigan. He works to utilize technology & engineering tools to transform healthcare and make positive impact on people’s lives by developing outcome-oriented, cost-effective and efficient healthcare solutions.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach. For the Zoom link and password and to be added to the weekly e-mail for the series, please RSVP. For additional questions, contact CHEPSseminar@umich.edu. Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Workshop / Seminar Mon, 21 Sep 2020 11:37:18 -0400 2020-09-21T16:30:00-04:00 2020-09-21T17:30:00-04:00 Center for Healthcare Engineering & Patient Safety (CHEPS) Workshop / Seminar photos of speakers & seminar information
Older Adults, Tech Use, and Social Well-Being during COVID-19 and Beyond (September 21, 2020 4:30pm) https://events.umich.edu/event/77493 77493-19875791@events.umich.edu Event Begins: Monday, September 21, 2020 4:30pm
Location: Off Campus Location
Organized By: Center for Healthcare Engineering & Patient Safety (CHEPS)

Nearly one in three older adults in the U.S. experienced some form of loneliness in 2019. The COVID-19 pandemic significantly restricted older adults’ (ages 65+) in-person social interactions, likely increasing loneliness among this demographic. Due to these restrictions, older adults have started to change their relationships with technology to communicate with family and friends at a distance using smartphones and computers. However, these technologies may not be accessible for all older adults. Voice-based technologies such as Amazon Alexa and Google Assistant can be more accessible to those with motor challenges or vision loss/blindness, yet have not been studied in-depth for how they can support older adult’s well-being. In this talk, I will discuss (1) a recent interview study with older adults COVID-19 technology use and (2) a recent analysis of more than 50,000 queries older adults made to the Amazon Alexa for social well-being. Early findings point to positive and negative aspects of using technology for well-being and aging.

Robin Brewer is an Assistant Professor in the School of Information at the University of Michigan. She also holds a courtesy appointment in Computer Science and Engineering. Dr. Brewer’s research in Human-Computer Interaction (HCI) asks (1) how experiences with technology can be more accessible to digitally constrained communities and (2) how these communities use technology for social well-being. Much of her work focuses on older adults and people with vision impairments. Dr. Brewer holds a Ph.D. in Technology and Social Behavior from Northwestern University, M.S. in Human-Centered Computing from University of Maryland - Baltimore County, and B.S. in Computer Science from the University of Maryland - College Park.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach. For the Zoom link and password and to be added to the weekly e-mail for the series, please RSVP. For additional questions, contact CHEPSseminar@umich.edu. Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Mon, 21 Sep 2020 11:54:41 -0400 2020-09-21T16:30:00-04:00 2020-09-21T17:30:00-04:00 Off Campus Location Center for Healthcare Engineering & Patient Safety (CHEPS) Lecture / Discussion photo of speaker with event information
2020 Precision Health Virtual Symposium (September 23, 2020 8:45am) https://events.umich.edu/event/75090 75090-19216540@events.umich.edu Event Begins: Wednesday, September 23, 2020 8:45am
Location: Off Campus Location
Organized By: Precision Health

Join us for a full-day virtual event celebrating and exploring the latest research in the fast-moving, multidisciplinary field of precision health.

This year's event focuses on the engagement of community participants to do research and the positive impact research can have on communities. Featuring national and local experts from engineering, medicine, nursing, pharmacy, public health, and many other areas, this event will provide thought-provoking sessions from multiple perspectives.

The morning session is geared toward researchers, with speakers sharing best practices and the importance of engaging a community. The afternoon session will be appropriate for both research participants and researchers, as we focus on the impact of research on community. You may attend either or both sessions. All are welcome.

A virtual poster session will feature work by funded Precision Health Investigators and other invited research groups.

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Livestream / Virtual Mon, 24 Aug 2020 14:37:59 -0400 2020-09-23T08:45:00-04:00 2020-09-23T15:15:00-04:00 Off Campus Location Precision Health Livestream / Virtual 2020 Precision Health Virtual Symposium
DCMB / CCMB Weekly Virtual Seminar (September 23, 2020 4:00pm) https://events.umich.edu/event/77143 77143-19798542@events.umich.edu Event Begins: Wednesday, September 23, 2020 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Talk title: Decision Support System Applications in Dentistry

Dr. Lucia Cevidanes is the Thomas and Doris Graber Professor of Dentistry and Associate Professor at the Department of Orthodontics at the University of Michigan, and a Diplomate of the American Board of Orthodontics. She is a practicing clinician who has published over 150 manuscripts on 3D imaging for which she has received research grants from the American Association of Orthodontics Foundation and the National Institute of Dental and Craniofacial Research. Her work has been recognized by the American Association of Orthodontists Thomas M. Graber Award, the B F Dewel Award, Milo Hellman Award, and the Wuehrmann award from the American Academy of Oral and Maxillofacial Radiology. Her interests include Artificial Intelligence and 3D Imaging to solve difficult clinical problems in dentistry, studying current and new treatment approaches and technical procedures, and understanding treatment outcomes for craniofacial anomalies and dentofacial deformities.

Zoom Link: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Lecture / Discussion Fri, 11 Sep 2020 15:27:53 -0400 2020-09-23T16:00:00-04:00 2020-09-23T17:00:00-04:00 Off Campus Location DCMB Seminar Series Lecture / Discussion Dr. Lucia Cevidanes is the Thomas and Doris Graber Professor of Dentistry and Associate Professor at the Department of Orthodontics at the University of Michigan
Joint Institute 10-year Celebration (September 24, 2020 7:00am) https://events.umich.edu/event/77360 77360-19844062@events.umich.edu Event Begins: Thursday, September 24, 2020 7:00am
Location: Off Campus Location
Organized By: UMMS Global REACH

Join representatives from Michigan Medicine and Peking University Health Science Center, along with renowned leaders in national and international academic medicine, for a virtual celebration of the Joint Institute.

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Livestream / Virtual Thu, 17 Sep 2020 10:31:16 -0400 2020-09-24T07:00:00-04:00 2020-09-24T09:00:00-04:00 Off Campus Location UMMS Global REACH Livestream / Virtual Joint Institute 10-year Celebration
CLINICAL SIMULATION CENTER BROWN BAG SERIES (September 29, 2020 12:00pm) https://events.umich.edu/event/77752 77752-19909894@events.umich.edu Event Begins: Tuesday, September 29, 2020 12:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

All Michigan Medicine faculty and staff are invited to attend the next installment of the Clinical Simulation Center Brown Bag series.

The series is designed to promote collaboration and best practices in simulation-based education and research and will allow faculty, staff and learners the opportunity to learn and share best practices in simulation-based education and assessment.

The next event, which will be held at noon on Tuesday, September 29th. James Cooke, MD, will discuss "Overarching Themes from ACS-AEI Accreditation Survey Best Practices 2011-2019.”

Click here for more information: https://medicine.umich.edu/dept/clinical-simulation-center/events/202009/csc-brown-bag-series-september-2020-part-ii

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Lecture / Discussion Fri, 25 Sep 2020 16:43:35 -0400 2020-09-29T12:00:00-04:00 2020-09-29T13:00:00-04:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion Adult resuscitation training at CSC
CSC Brown Bag Seminar (September 29, 2020 12:00pm) https://events.umich.edu/event/77778 77778-19923732@events.umich.edu Event Begins: Tuesday, September 29, 2020 12:00pm
Location: Off Campus Location
Organized By: Clinical Simulation Center

Dr. James Cooke, Associate Professor Departments of Family Medicine & Learning Health Sciences and Executive Director of the Michigan Medicine Clinical Simulation Center will present compiled themes from 9 years of simulation center accreditation data which distills best practices from 247 accreditation reviews into eight overarching themes on everything from curriculum development to governance. Findings were also electronically published in ahead of print and available at https://www.sciencedirect.com/science/article/pii/S0039606020303858

Please share this with any simulation colleagues or health system/medical school administrators who might be interested.

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Workshop / Seminar Sun, 27 Sep 2020 11:22:20 -0400 2020-09-29T12:00:00-04:00 2020-09-29T13:00:00-04:00 Off Campus Location Clinical Simulation Center Workshop / Seminar CSC-Med Sci 2 PICU
Center for Global Health Equity Introductory Seminar (September 29, 2020 5:00pm) https://events.umich.edu/event/77700 77700-19901736@events.umich.edu Event Begins: Tuesday, September 29, 2020 5:00pm
Location: Off Campus Location
Organized By: Center for Global Health Equity

Please join us for the Introductory Seminar for the Center for Global Health Equity, where we will discuss:
What is the purpose of the Center?
What has been our journey to date?
Where are we going?

Speakers Include:
Bhramar Mukherjee, PhD
Nancy Love, PhD
Joseph Kolars, MD
John Ayanian, MD, MPP
Laura Rozek, PhD
Andries Coetzee, PhD

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Workshop / Seminar Thu, 24 Sep 2020 16:32:00 -0400 2020-09-29T17:00:00-04:00 2020-09-29T18:30:00-04:00 Off Campus Location Center for Global Health Equity Workshop / Seminar Event Speakers
DCMB / CCMB Weekly Virtual Seminar - Xiaotian Zhang, Ph.D. (September 30, 2020 4:00pm) https://events.umich.edu/event/77549 77549-19883820@events.umich.edu Event Begins: Wednesday, September 30, 2020 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract: The human genome is organized into small compartments to allow for the proper gene expression regulation in the physiological process. With the advance of next-generation sequencing and imaging technologies, we can now investigate how the genome is folded into 3D space and how the 3D genomic organization regulates gene expression in development and disease. Currently, most of the studies are focusing on CTCF and cohesion complex which partner together to facilitate the formation of topological associated domains (TAD). The presenter will mainly discuss his recently published work on the DNA methylation -3D genomics cross-talk. Unpublished work on the 3D genomics in AML will be discussed as well.

Short bio: Xiaotian Zhang obtained his Ph.D. at Baylor College of Medicine with Dr. Margaret Goodell on the role of DNA methylation synergy in leukemia development. He was previously the Van Andel special postdoc fellow in Gerd Pfeifer lab working on the 3D genomics in normal hematopoietic stem cell and leukemia. He is now a Research track faculty (Research Investigator) in Pathology Department under Tomek Cierpicki working on the HOXA regulation in leukemia development. Xiaotian's research focuses on the epigenetic regulation of key pathogenic genes in leukemia, particularly on high order chromatin structure in disease. He published on Nature Genetics, Molecular Cell and Blood as the first author and corresponding authors.

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Lecture / Discussion Tue, 22 Sep 2020 09:31:31 -0400 2020-09-30T16:00:00-04:00 2020-09-30T17:00:00-04:00 Off Campus Location DCMB Seminar Series Lecture / Discussion Xiaotian Zhang, Ph.D., Research Investigator in the Department of Pathology at the University of Michigan
RNA Seminar featuring: Chase Weidmann, Washington University School of Medicine in St. Louis (October 5, 2020 4:00pm) https://events.umich.edu/event/76147 76147-19665691@events.umich.edu Event Begins: Monday, October 5, 2020 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

ZOOM REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_y9HTFl5RSOSJTJ5qtlhVcw

Keywords: mRNA regulation, noncoding RNA, RNA Structure, RNP granules

Abstract:
Chase Weidmann, Ph.D. has contributed broadly to the field of RNA Biology during his career, studying mechanisms of codon bias during translation, post-transcriptional regulation of mRNAs by RNA-binding proteins, the folding of long non-coding RNAs, and how RNA-protein interaction networks contribute to the function and assembly of functional RNP particles. Chase developed a chemical probing strategy and next-gen sequencing technology, called RNP-MaP, that maps the location of and cooperation between multi-protein networks on RNAs in live cells. Going forward, Chase is interested in understanding how alterations in RNA-binding protein profiles, a cell’s “RBPome”, confer deleterious activities onto noncoding RNAs in human disease, especially in cancer. To further empower this work and his future research program, Chase is now generating and integrating protein mass spectrometry data into his RBPome projects.

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Lecture / Discussion Wed, 16 Sep 2020 09:01:52 -0400 2020-10-05T16:00:00-04:00 2020-10-05T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion photo
A Virtual Event: Per- and polyfluoroalkyl substances (PFAS): Exposure, Toxicity, and Policy (October 7, 2020 1:00pm) https://events.umich.edu/event/77430 77430-19854020@events.umich.edu Event Begins: Wednesday, October 7, 2020 1:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

This M-LEEaD Virtual Symposium will focus on issues related to exposure, toxicity, and policy in the unfolding PFAS contamination across Michigan and globally. Speakers will each focus on one of these topics related to their expertise.

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Livestream / Virtual Fri, 18 Sep 2020 12:36:19 -0400 2020-10-07T13:00:00-04:00 2020-10-07T15:00:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Livestream / Virtual 10.7.20 Poster
DCMB / CCMB Weekly Seminar (October 7, 2020 4:00pm) https://events.umich.edu/event/78232 78232-19996937@events.umich.edu Event Begins: Wednesday, October 7, 2020 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract: The chromosomes of the human genome are organized in three-dimensions by compartmentalizing the cell nucleus and different genomic loci also interact with each other. However, the principles underlying such nuclear genome organization and its functional impact remain poorly understood. In this talk, I will introduce some of our recent work in developing machine learning methods by utilizing whole-genome mapping data to study the higher-order genome organization. Our methods reveal the spatial localization of chromosome regions and exploit chromatin interactome patterns within the cell nucleus in different cellular conditions, across mammalian species, and also in single-cell resolution. We hope that these algorithms will provide new insights into the principles of nuclear spatial organization.

Bio: Jian Ma is an Associate Professor in the Computational Biology Department within the School of Computer Science at Carnegie Mellon University. He was previously on the faculty of the University of Illinois at Urbana-Champaign. His lab develops algorithms to study the structure and function of the human genome with a focus on nuclear organization, gene regulation, comparative genomics, and single cell biology. He received several awards, including an NSF CAREER award and a Guggenheim Fellowship. He is the Contact PI of a UM1 Center project in the NIH 4D Nucleome Program (Phase 2; 2020-2025). https://www.cs.cmu.edu/~jianma/

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Tue, 06 Oct 2020 12:47:39 -0400 2020-10-07T16:00:00-04:00 2020-10-07T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual
Virtual Physician Job Shadow: Watch Live Shoulder Surgery (October 8, 2020 8:45am) https://events.umich.edu/event/77717 77717-19907692@events.umich.edu Event Begins: Thursday, October 8, 2020 8:45am
Location: Off Campus Location
Organized By: LSA Opportunity Hub

Elective surgeries are a cornerstone of our healthcare system that’s focused on increasing a patient’s well-being and quality of life. At a time when elective surgeries have been impacted significantly by the pandemic with longer waiting periods, reschedules, or even cancellations, the ability to schedule those potentially life-changing operations in advance has been compromised. Join us for a live look into an arthroscopic rotator cuff surgery as Dr. Nikhil Verma uses advanced surgical techniques to fix a tear in a torn rotator cuff.


About Dr. Verma:

Dr. Verma is a Sports Medicine and Shoulder physician who performs over 500 procedures per year. He specializes in the treatment of the shoulder, elbow, and knee with an emphasis on advanced arthroscopic reconstructive techniques. He is the Director of the Division of Sports Medicine and Director of the Sports Medicine Fellowship Program at Rush University Medical Center. In addition, Dr. Verma serves as a team physician for the Chicago White Sox and Chicago Bulls.


You should attend this session if you are:

- A liberal arts and/or science undergraduate student
- Searching for opportunities to shadow a physician at their clinical practice
- Exploring careers and specialities in medicine and healthcare
- Looking to explore different medical fields from the perspective of a physician

What you’ll gain from attending:

- The opportunity to watch a live surgery performed by a physician and his team using leading technology in the field
- The chance to ask the physician questions about the surgery and his work more broadly
- Gain insight into how the physicians are handling elective surgeries during COVID-19

RSVP today to reserve your spot to view this live surgery. Seats will be capped at 95. Once your RSVP is complete, you will receive a confirmation email with the event details and a link to access the live viewing before the event takes place.

Elective surgeries are a cornerstone of our healthcare system that’s focused on increasing a patient’s well-being and quality of life. At a time when elective surgeries have been impacted significantly by the pandemic with longer waiting periods, reschedules, or even cancellations, the ability to schedule those potentially life-changing operations in advance has been compromised. Join us for a live look into an arthroscopic rotator cuff surgery as Dr. Nikhil Verma uses advanced surgical techniques to fix a tear in a torn rotator cuff.


About Dr. Verma:


Dr. Verma is a Sports Medicine and Shoulder physician who performs over 500 procedures per year. He specializes in the treatment of the shoulder, elbow, and knee with an emphasis on advanced arthroscopic reconstructive techniques. He is the Director of the Division of Sports Medicine and Director of the Sports Medicine Fellowship Program at Rush University Medical Center. In addition, Dr. Verma serves as a team physician for the Chicago White Sox and Chicago Bulls.


You should attend this session if you are:

A liberal arts and/or science undergraduate student
Searching for opportunities to shadow a physician at their clinical practice
Exploring careers and specialities in medicine and healthcare
Looking to explore different medical fields from the perspective of a physician
What you’ll gain from attending:

The opportunity to watch a live surgery performed by a physician and his team using leading technology in the field
The chance to ask the physician questions about the surgery and his work more broadly
Gain insight into how the physicians are handling elective surgeries during COVID-19
RSVP today to reserve your spot to view this live surgery. Seats will be capped at 75. Once your RSVP is complete, you will receive a confirmation email with the event details and a link to access the live viewing before the event takes place.

The LSA Opportunity Hub aims to deliver inclusive and accessible experiences and welcomes all LSA students to participate. This event will be hosted on Zoom (learn more about Zoom accessibility) and can be accessed by phone or computer. Presentation materials will be shared in advance and live captioning will be provided. To request other accommodations please contact Paige Baker at paigebak@umich.edu or 734.763.4674. so we can make arrangements.

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Livestream / Virtual Tue, 06 Oct 2020 09:31:37 -0400 2020-10-08T08:45:00-04:00 2020-10-08T09:45:00-04:00 Off Campus Location LSA Opportunity Hub Livestream / Virtual two surgeons in operating room
Engineering an immunological niche for early detection of immune dysfunction (October 8, 2020 12:00pm) https://events.umich.edu/event/77515 77515-19877791@events.umich.edu Event Begins: Thursday, October 8, 2020 12:00pm
Location: Off Campus Location
Organized By: Office of Research School of Dentistry

Lonnie Shea, PhD
William and Valerie Hall Chair
Steven A. Goldstein Collegiate Professor
Biomedical Engineering
University of Michigan

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Presentation Mon, 21 Sep 2020 13:40:07 -0400 2020-10-08T12:00:00-04:00 2020-10-08T13:00:00-04:00 Off Campus Location Office of Research School of Dentistry Presentation flyer
How Lean Culture is Fighting Against the Coronavirus (October 12, 2020 4:30pm) https://events.umich.edu/event/78063 78063-19957560@events.umich.edu Event Begins: Monday, October 12, 2020 4:30pm
Location: Off Campus Location
Organized By: Center for Healthcare Engineering & Patient Safety (CHEPS)

We’ve all been impacted by the COVID-19 pandemic in different ways. For me, one of the ways was receiving a call to “deploy” to our ventilator manufacturing facility to help make an unprecedented volume of ventilators as fast as possible. The world needed ventilators to fight COVID-19 and we needed to ramp production using our best manufacturing methodologies.Using Lean techniques was once described by one of its founding leaders, Taiichi Ohno, as “looking at the timeline, from the moment the customer gives us an order to the point when we collect the cash. And we are reducing the timeline by reducing the non-value adding wastes.” GE Healthcare has incorporated Lean into its operational fabric just as described in the quote to delivery reliable daily output as well as to take on new manufacturing challenges. In this presentation, I will describe the challenge that COVID-19 presented to our company, to the production process & to the cross-functional group of people involved in supporting production. To tell this story, I will be sharing some basics about Lean Methodologies and how it influenced our approach, communications & the execution of an unprecedented ventilator output. Finally, I will discuss how these same methodologies and approach can be used to positively impact your business, career, or challenge you’re facing.

Passion: My passion is serving the Healthcare community by educating eager learners, utilizing Lean-6 Sigma methodologies & incorporating Advanced Technologies to challenge the status quo & bring about meaningful improvement.

Experience: I’ve been with GE Healthcare for 15 years in a variety of roles from a manufacturing engineer, to a site & national Lean Leader to a multi-state field service director. These roles have including manufacturing, service & commercial elements to them and always included a primary focus on healthcare. Additionally, I have worked within the aviation, energy & financial industries through cross-business projects. With my experience, I was recently called on by GE to help during the COVID-19 response to drive increased output, improved quality & to build a supportive culture in our ventilator manufacturing business. Additionally, I have used this knowledge to start an education & consulting group focused on Lean methodologies called ripple Solutions LLC. My small business has allowed me to expand outside of healthcare & connect with the printing, distribution, university & non-healthcare manufacturing industries.

Education: I have a degree in Industrial Engineering with additional courses in Medical Sciences from University of Michigan, class of 2007. I am a GE Healthcare Operations Management Leadership Program graduate, I’m a certified Black Belt in DMAIC Lean Six Sigma and I’m Green Belt certified in DFSS Six Sigma. I have also received extensive GE Healthcare & Shingijtsu Lean training.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach. For the Zoom link and password and to be added to the weekly e-mail for the series, please RSVP. For additional questions, contact CHEPSseminar@umich.edu. Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Thu, 01 Oct 2020 14:52:38 -0400 2020-10-12T16:30:00-04:00 2020-10-12T17:30:00-04:00 Off Campus Location Center for Healthcare Engineering & Patient Safety (CHEPS) Lecture / Discussion photo of speaker with event information
DCMB / CCMB Weekly Seminar (October 14, 2020 4:00pm) https://events.umich.edu/event/78234 78234-19996940@events.umich.edu Event Begins: Wednesday, October 14, 2020 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract: Gaussian processes provide flexible non-parametric models of data and we are using them to model temporal and spatial patterns in gene expression. Single-cell omics measurements are destructive and one cannot follow the high-dimensional dynamics of genes across time in one cell. Similarly, the spatial context of cells is often lost or only known with reduced resolution. Computational methods are widely used to infer pseudo-temporal orderings of cells or to infer spatial locations. We show how Gaussian processes (GPs) can be used to model temporal and spatial relationships between genes and cells in these datasets. As examples I will show how we use Bayesian GPLVMs with informative priors to infer pseudo-temporal orderings for single-cell time course data [1] and branching GPs to identify gene-specific bifurcation points across pseudotime [2]. Gene expression data are often summarized as counts and there may be many zero values in the data due to limited sequencing depth. We therefore recently extended these methods to use negative binomial or zero-inflated negative binomial likelihoods and we show that this can lead to much improved performance over standard Gaussian noise models when identifying spatially varying genes from spatial transcriptomics data [3].

[1] Ahmed, S., Rattray, M., & Boukouvalas, A. (2019). GrandPrix: scaling up the Bayesian GPLVM for single-cell data. Bioinformatics, 35(1), 47-54.

[2] Boukouvalas, A., Hensman, J., & Rattray, M. (2018). BGP: identifying gene-specific branching dynamics from single-cell data with a branching Gaussian process. Genome biology, 19(1), 65.

[3] BinTayyash, N., Georgaka, S., John, S. T., Ahmed, S., Boukouvalas, A., Hensman, J., & Rattray, M. (2020). Non-parametric modelling of temporal and spatial counts data from RNA-seq experiments. Bioarxiv https://doi.org/10.1101/2020.07.29.227207

Short bio: Magnus Rattray is Professor of Computational and Systems Biology at the University of Manchester and Director of the Institute for Data Science & AI. He works on the development of methods for machine learning and Bayesian inference with applications to large-scale biological and medical datasets. He has a long-standing interest in longitudinal data analysis and a more recent interest in modelling single-cell, spatial omics and live cell imaging microscopy data. He is a Fellow of the ELLIS Health Programme and the Alan Turing Institute and his research is funded by a Wellcome Trust Investigator Award.

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Tue, 06 Oct 2020 13:35:21 -0400 2020-10-14T16:00:00-04:00 2020-10-14T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual Magnus Rattray, PhD (Professor of Computational and Systems Biology, University of Manchester)
Honors Grand Rounds with Mohammed Moursi, MD (October 14, 2020 7:00pm) https://events.umich.edu/event/76326 76326-19687519@events.umich.edu Event Begins: Wednesday, October 14, 2020 7:00pm
Location: Off Campus Location
Organized By: LSA Honors Program

Join Stephanie Chervin, Honors premed advisor, for a virtual live discussion with Honors alum Mohammed Moursi, MD; Chief of Vascular Surgery University of Arkansas. This program is for current LSA Honors Program students only. A link to the virtual event will be sent to all registrants before the event.

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Presentation Fri, 28 Aug 2020 15:29:24 -0400 2020-10-14T19:00:00-04:00 2020-10-14T20:00:00-04:00 Off Campus Location LSA Honors Program Presentation Dr. Moursi
3D organization of human genome in development and disease – A perspective from 3D genome engineering (October 15, 2020 12:00pm) https://events.umich.edu/event/78431 78431-20044394@events.umich.edu Event Begins: Thursday, October 15, 2020 12:00pm
Location: Off Campus Location
Organized By: Office of Research School of Dentistry

Xiaotian Zhang, PhD
Research Investigator
Department of Pathology
Tomasz Cierpicki/Jolanta Grembecka lab
University of Michigan

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Lecture / Discussion Mon, 12 Oct 2020 12:04:51 -0400 2020-10-15T12:00:00-04:00 2020-10-15T13:00:00-04:00 Off Campus Location Office of Research School of Dentistry Lecture / Discussion Zhang
The Massey Family Foundation Virtual TBI Conference (October 15, 2020 1:00pm) https://events.umich.edu/event/77046 77046-19790555@events.umich.edu Event Begins: Thursday, October 15, 2020 1:00pm
Location: Off Campus Location
Organized By: Michigan Center for Integrative Research in Critical Care (MCIRCC)

The Michigan Center for Integrative Research in Critical Care (MCIRCC) invites you to the 2020 Massey Family Foundation Virtual TBI Conference.

Supported by the Joyce & Don Massey Family Foundation, the conference aims to improve the outcomes of those who suffer severe traumatic brain injuries by sharing the latest insights and innovations in the field, and by supporting technology development and translational and clinical research that impacts the “golden hours” of care.

The 2020 conference will kick off with a presentation by keynote speaker Daniel Spaite, MD, FACEP, Virginia Piper Distinguished Chair of Emergency Medicine and Director of the EMS Research Collaboration at the University of Arizona College of Medicine. The afternoon’s events will also include a roundtable discussion and live Q&A with a panel of field and industry leaders.

For more information and to register: https://mcircc.umich.edu/tbi2020

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Conference / Symposium Thu, 10 Sep 2020 13:19:23 -0400 2020-10-15T13:00:00-04:00 2020-10-15T15:30:00-04:00 Off Campus Location Michigan Center for Integrative Research in Critical Care (MCIRCC) Conference / Symposium Massey Family Foundation Virtual TBI Conference
The Psychology of Pathogen Avoidance: How Does It Work and How Relevant Is It for Understanding Pandemic Behavior? (October 15, 2020 5:00pm) https://events.umich.edu/event/78467 78467-20050321@events.umich.edu Event Begins: Thursday, October 15, 2020 5:00pm
Location: Off Campus Location
Organized By: Weinberg Institute for Cognitive Science

Infectious diseases have been some of humanity's biggest killers. Fortunately, we possess an evolved psychology of pathogen avoidance - a system of mental mechanisms that help us identify, track, and respond to such dangers, thereby reducing risks of infection. Unfortunately, this system is imperfect - we mistake which information is diagnostic, leading to faulty assumptions, pernicious attitudes, and bad decisions. I will review recent work in our lab focusing on how we conceptualize pathogen threats and consequences of this process. Additionally, I will discuss when our understanding of pathogen avoidance psychology can inform explanations of pandemic behavior, and more importantly, why it might not.

Zoom link: https://umich.zoom.us/j/96257205534
Meeting ID: 962 5720 5534
Password: cogsci

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Lecture / Discussion Tue, 13 Oct 2020 09:22:13 -0400 2020-10-15T17:00:00-04:00 2020-10-15T18:00:00-04:00 Off Campus Location Weinberg Institute for Cognitive Science Lecture / Discussion csc logo
Tracking A Pandemic: An Analytical View of the COVID-19 Progression and Implications for Business Plans to Re-Engage in the Economy (October 19, 2020 4:30pm) https://events.umich.edu/event/78333 78333-20010773@events.umich.edu Event Begins: Monday, October 19, 2020 4:30pm
Location: Off Campus Location
Organized By: Center for Healthcare Engineering & Patient Safety (CHEPS)

The SARS-CoV-2 virus caused widespread disruption across the globe, affecting literally every aspect of human life. The business environment was not spared in this disruption, as customers, the workforce, workplace environments and supply chains were each turned upside-down, almost overnight. Operating practices needed to be challenged, re-engineered and re-adopted – at the speed of business. That is akin to replacing the aircraft engine while the plane is mid-flight.

The challenge faced by business leaders from the outset of the pandemic, and remains true today, is that objective, analytical information on the state of the virus was and remains woefully inadequate. Further, every organization operating in multiple geographical and political jurisdictions has to navigate different and every-changing rules governing the ability to conduct operations.

In mid-March, I launched an effort to build a repository of critical virus-related information (tests, positives, infections, recoveries, fatalities) at various levels of granularity – world, country, state or province, and metropolitan area. From this, I established a daily reporting mechanism and underlying analyses, designed to equip business leaders, economic and investment advisors and clinicians with insight about the state of the virus spread and underlying trends. My intent was to inform these leaders with actionable intelligence, free of both the fearmongering and denial perspectives that were dominating the general and social media.

These efforts have resulted in my direct engagement with four organizations’ operational planning efforts around the pandemic: two for-profit organizations involved in the manufacture and distribution of critical medical/life sciences products to consumers around the globe, a not-for-profit agency supporting families of critically-ill children and a governmental agency charged with administering a state-wide pandemic response effort. Additionally, I provide daily reports on the state of the virus to an estimated 2,000 clinicians, health organization managers, economists and investment managers.

These lessons provide strong insight for the analytical practitioner. Through this effort, I have discovered the challenges of making actionable sense of data from a novel virus . . . in real-time. Data sources and definitions are in constant flux, external reporting lacks analytical rigor, and, new knowledge frequently trumps previously held scientific beliefs. More profoundly, models reported on and used extensively by government officials are often accepted as dogma but, may be nothing more than assumptions built upon several more layers of assumptions.

Mark currently serves as the Board Chair of Crown Healthcare Laundry Inc., a Quilvest Private Equity-portfolio company and as Strategic Advisor to Terso Solutions Inc., a subsidiary of Promega that provides Real Time Location Services (RTLS) for field-based inventory of leading medical implant and biotech companies.

He previously served as chief strategist and business intelligence officer for Owens & Minor, Inc.; as a Partner in the healthcare consulting practice at Ernst & Young, where he launched the firm’s health care supply chain practice; and as a Management Engineer at the Detroit Medical Center.

Mark also serves on the National Advisory Board of the Congenital Heart Center at C.S. Mott Children’s Hospital at the University of Michigan, and on the Advisory Board of the Medical Device Supply Chain Council. He recently completed two terms on the Board of the Bellwether League Inc.

In the midst of the COVID-19 situation, Mark is producing an objective and analytical daily report on the virus progression in the US and worldwide. This report has become a go-to source for nearly 2,000 physicians, scientists, health system and supplier executives, economists, investment bankers and, one former head of the Centers for Medicare and Medicaid Services.

Mark holds an MBA from the Ross School of Business at the University of Michigan and a Bachelor of Science in Industrial & Operations Engineering, also from the University of Michigan.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach. For the Zoom link and password and to be added to the weekly e-mail for the series, please RSVP. For additional questions, contact CHEPSseminar@umich.edu. Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Thu, 08 Oct 2020 11:38:55 -0400 2020-10-19T16:30:00-04:00 2020-10-19T17:30:00-04:00 Off Campus Location Center for Healthcare Engineering & Patient Safety (CHEPS) Lecture / Discussion photo of speaker with event information
CSCS/MIDAS/MICDE Seminar | Predicting the second wave of COVID-19 in Washtenaw County, MI (October 20, 2020 11:30am) https://events.umich.edu/event/76629 76629-19733025@events.umich.edu Event Begins: Tuesday, October 20, 2020 11:30am
Location: Off Campus Location
Organized By: The Center for the Study of Complex Systems

This seminar is co-sponsored by the Michigan Institute for Computational Discovery & Engineering (MICDE) and the Michigan Institute for Data Science (MIDAS)

VIRTUAL SEMINAR LINK: myumi.ch/v2ZYv

In this work, we study and predict the spread of COVID-19 in Washtenaw County, MI through applying a discrete and stochastic network-based modeling framework. In this framework, we construct contact networks based on synthetic population datasets specific for Washtenaw County that are derived from US Census datasets. We assign individuals to households, workplaces, schools, and group quarters (such as prisons or long term care facilities). In addition, we assign casual contacts to each individual at random. Using this framework, we explicitly simulate Michigan-specific government-mandated workplace and school closures as well as social distancing measures. We perform sensitivity analyses to identify key model parameters and mechanisms contributing to the observed disease burden in the three months following the first observed cases of COVID-19 in Michigan. We then consider several scenarios for relaxing restrictions and reopening workplaces to predict what actions would be most prudent. In particular, we consider the effects of 1) different timings for reopening, and 2) different levels of workplace vs. casual contact re-engagement. Through simulations and sensitivity analyses, we explore mechanisms driving the magnitude and timing of a second wave of infections upon re-opening.

This work is based on Dr. Renardy's *paper in press* in the *Journal of Theoretical Biology* with coauthors:
Marisa Eisenberg, UM Complex Systems & Math (LSA) and Epidemiology (Public Health)
Denise Kirschner, UM Department of Microbiology & Immunology (Medical School)

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Livestream / Virtual Mon, 28 Sep 2020 14:00:42 -0400 2020-10-20T11:30:00-04:00 2020-10-20T13:00:00-04:00 Off Campus Location The Center for the Study of Complex Systems Livestream / Virtual Photo of Marissa Renardy
LHS Collaboratory-LHS as a Driver of Diversity, Equity, and Inclusion (October 20, 2020 11:30am) https://events.umich.edu/event/77545 77545-19879862@events.umich.edu Event Begins: Tuesday, October 20, 2020 11:30am
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Healthcare and health remain unconscionably inequitable. This year, the disproportionate toll the COVID-19 pandemic has taken on those historically least well-served by our health system, has highlighted the pressing societal challenge of health disparities.

Beyond simply striving to do no harm, Learning Health Systems (LHSs) have the potential to serve as forces for justice in healthcare and health; indeed, they can be powerful drivers of diversity, equity, and inclusion. LHSs are anchored in multi-stakeholder consensus Core Values that explicitly incorporate principles such as inclusiveness, transparency, and accessibility. Their proximal goal is "to efficiently and equitably serve the learning needs of all participants, as well as the overall public good."

The October 2020 LHS Collaboratory will share lessons from health advocates working on the front lines to make healthcare and health more equitable. These thought leaders and do-ers will illuminate the transformative power of LHSs - and the diverse and inclusive communities of interest that are collaborating to realize them.

Moderator:
Joshua C. Rubin, JD, MBA, MPP, MPH
Program Officer, Learning Health System Initiatives, Department of Learning Health Sciences, University of Michigan

Panelists:
Luis Belén
Chief Executive Officer of the National Health IT Collaborative for the Underserved (NHIT Collaborative)

Danielle Brooks, JD
Director of Health Equity, Amerihealth Caritas

Melissa S. Creary, PhD, MPH, Assistant Professor
Department of Health Management and Policy
School of Public Health, University of Michigan

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Lecture / Discussion Sun, 27 Sep 2020 21:18:37 -0400 2020-10-20T11:30:00-04:00 2020-10-20T13:00:00-04:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion LHS Collaboratory Logo puzzle pieces