Happening @ Michigan https://events.umich.edu/list/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. Project Highlights from the 3D Innovations Lab - Deborah M. Rooney, PhD (March 3, 2021 9:00am) https://events.umich.edu/event/82680 82680-21161628@events.umich.edu Event Begins: Wednesday, March 3, 2021 9:00am
Location: Off Campus Location
Organized By: Clinical Simulation Center

All Michigan Medicine faculty and staff are invited to attend the next installment of the Clinical Simulation Center Brown Bag series.

The series is designed to promote collaboration and best practices in simulation-based education and research and will allow faculty, staff and learners the opportunity to learn and share best practices in simulation-based education and assessment.

The next event, which will be held virtually at noon on March 23rd in the CSC will discuss current projects in the 3D and Innovation Lab.

Attendees can meet the faculty and BME students who are solving simulation problems at Michigan Medicine.

Projects that will be discussed include:
- Development of a task trainer used to support cardiac surgery skills
- Development of a traumatic leg amputation model
- 3D Innovations Lab and Social Media

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Lecture / Discussion Wed, 03 Mar 2021 09:10:33 -0500 2021-03-03T09:00:00-05:00 2021-03-03T10:00:00-05:00 Off Campus Location Clinical Simulation Center Lecture / Discussion 2019-2020-3DI Lab TEAMclean
RNA Seminar featuring: Melissa Moore, Moderna Therapeutics (March 3, 2021 4:00pm) https://events.umich.edu/event/81265 81265-20879904@events.umich.edu Event Begins: Wednesday, March 3, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

**Please register here for March 3rd seminar: https://umich.zoom.us/webinar/register/WN_l0kt_NjpRh-f33LJj7KGpA

Dr. Moore will address scientists and non-scientists, and will take live questions.

In her role as Chief Scientific Officer, Platform Research, Dr. Melissa Moore is responsible for leading mRNA biology, delivery and computation science research at Moderna. She joined Moderna in 2016 from the University of Massachusetts Medical School, where she served as Professor of Biochemistry & Molecular Pharmacology, Eleanor Eustis Farrington Chair in Cancer Research and a long-time Investigator at the Howard Hughes Medical Institute (HHMI). Dr. Moore was also a founding Co-Director of the RNA Therapeutics Institute (RTI) at UMassMed, and was instrumental in creating the Massachusetts Therapeutic and Entrepreneurship Realization initiative (MassTERi), a faculty-led program intended to facilitate the translation of UMMS discoveries into drugs, products, technologies and companies. Dr. Moore is an elected member of the National Academy of Sciences (2017) and a Fellow of the American Academy of Arts and Sciences (2019).

Dr. Moore holds a B.S. in Chemistry and Biology from the College of William and Mary, and a Ph.D. in Biological Chemistry from MIT, where she specialized in enzymology under Prof. Christopher T. Walsh. She began working on RNA metabolism during her postdoctoral training with Phillip A. Sharp at MIT. During her 23 years as a faculty member, first at Brandeis and then at UMassMed, her research encompassed a broad array of topics related to the roles of RNA and RNA-protein (RNP) complexes in gene expression, and touched on many human diseases including cancer, neurodegeneration, and preeclampsia.

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Lecture / Discussion Wed, 10 Feb 2021 19:47:49 -0500 2021-03-03T16:00:00-05:00 2021-03-03T17:00:00-05:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Melissa Moore, Ph.D., Moderna Therapeutics
DCM&B Tools and Technology Seminar (March 4, 2021 12:00pm) https://events.umich.edu/event/79918 79918-20515551@events.umich.edu Event Begins: Thursday, March 4, 2021 12:00pm
Location: Off Campus Location
Organized By: DCMB Tools and Technology Seminar

Tool link: https://github.com/rdcrawford/cognac

URL for remote viewing: https://umich-health.zoom.us/j/94886745590?pwd=LzhLU243K2ZhbXNzU1BJRHQ5V25BZz09

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Livestream / Virtual Fri, 19 Feb 2021 14:34:43 -0500 2021-03-04T12:00:00-05:00 2021-03-04T13:00:00-05:00 Off Campus Location DCMB Tools and Technology Seminar Livestream / Virtual
BME 500 Seminar: Danielle Bassett (March 4, 2021 4:00pm) https://events.umich.edu/event/81388 81388-20889818@events.umich.edu Event Begins: Thursday, March 4, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

TBD

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Lecture / Discussion Wed, 27 Jan 2021 21:05:02 -0500 2021-03-04T16:00:00-05:00 2021-03-04T17:00:00-05:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Michigan India Conference (March 5, 2021 9:00am) https://events.umich.edu/event/82608 82608-21137865@events.umich.edu Event Begins: Friday, March 5, 2021 9:00am
Location: Off Campus Location
Organized By: Michigan India Conference

Have you heard the good news? The annual Michigan India Conference is back, and we’re going virtual for 2021.

We hope to see you there. We have a series of influential speakers you won’t want to miss! The theme for this year's conference is Stability & Change, so we have brought you the best decision-makers and thinkers surrounding India's government, India's economy and the Indian consumer. Get a chance to learn about the latest trends, opportunities, and maybe even a chance to network with some of India’s prestigious figures.

The Michigan India Conference gives business leaders, students, alumni, policymakers, and anyone interested, a chance to learn more about what drives this dynamic economy. Whether you are interested in doing business in India or want to learn more about policy and government, the Michigan India Conference is open to all. We hope you will join us.

Take advantage of our first fully-digital conference!
Register today: https://forms.gle/ug5R9KMKs1dXu28bA

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Conference / Symposium Tue, 09 Mar 2021 13:06:47 -0500 2021-03-05T09:00:00-05:00 2021-03-05T10:00:00-05:00 Off Campus Location Michigan India Conference Conference / Symposium Michigan India Conference
Bioethics Discussion: Infection (March 9, 2021 7:00pm) https://events.umich.edu/event/58838 58838-14563730@events.umich.edu Event Begins: Tuesday, March 9, 2021 7:00pm
Location: Off Campus Location
Organized By: The Bioethics Discussion Group

A discussion spreading to others.

Join us at: https://umich.zoom.us/j/99926126455.

A few readings to consider:
––Evidence and Effectiveness in Decision-Making for Quarantine
––The 1918 Influenza Pandemic: Insights for the 21st Century
––From SARS to Ebola: Legal and Ethical Considerations for Modern Quarantine
––Responding to the COVID-19 pandemic: Ethical considerations for conducting controlled human infection studies

For more information and/or to receive a copy of the readings visit http://belmont.bme.umich.edu/bioethics-discussion-group/discussions/057-infection/.

––
Feel free to stop by the website, not even the blog is viral: https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Fri, 08 Jan 2021 09:40:23 -0500 2021-03-09T19:00:00-05:00 2021-03-09T20:30:00-05:00 Off Campus Location The Bioethics Discussion Group Lecture / Discussion Infection
CCMB / DCMB Weekly Seminar Series (March 10, 2021 4:00pm) https://events.umich.edu/event/82479 82479-21108092@events.umich.edu Event Begins: Wednesday, March 10, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract: Single-cell technologies have transformed biomedical research in the last few years. With single-cell sequencing, we can now simultaneously measure thousands of genomics features in a large number of cells, which provides an ultrahigh resolution phenotypic map for each individual. However, single-cell protocols are complex. Even with the most sensitive platforms, the data are often sparse and noisy. Recent development of single-cell multi-omics and spatial transcriptomics technologies further imposed additional challenges on data integration. In this talk, I will present several machine learning methods that my group recently developed for single-cell and spatial transcriptomics data analysis. I will discuss methods for simultaneous denoising, clustering and batch effect correction, single-cell multi-omics data integration, identification of spatially variable genes, generation of super-resolution gene expression, and inference of cell type distribution in spatial transcriptomics. I will illustrate our methods by showing results from ongoing collaborations on cardiometabolic disease and applications to brain and cancer data.
* * *
Biography: Dr. Li’s research interests include statistical genetics and genomics, bioinformatics, and computational biology. The central theme of her current research is to use statistical and computational approaches to understand cellular heterogeneity in human-disease-relevant tissues, to characterize gene expression diversity across cell types, to study the patterns of cell state transition and crosstalk of various cells using data generated from single-cell and spatial transcriptomics studies, and to translate these findings to the clinics. In addition to methods development, Dr. Li is also interested in collaborating with researchers seeking to identify complex disease susceptibility genes and acting cell types. She is Director of Biostatistics for the Gene Therapy Program at Penn, where she advises biostatistics and bioinformatics analysis for various gene therapy studies. She is also Chair of the Graduate Program in Biostatistics. Dr. Li actively serves in the scientific community. She served as a regular member for the NIH Genomics, Computational Biology and Technology (GCAT) study section for 6 years, and the NHGRI Center for Inherited Disease Research (CIDR) for 3 years. She is an Associate Editor of Annals of Applied Statistics, Statistics in Biosciences, PLOS Computational Biology, and Human Genetics and Genomics Advances. She is an elected member of the International Statistical Institute and a Fellow of the American Statistical Association.

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Wed, 24 Feb 2021 12:57:46 -0500 2021-03-10T16:00:00-05:00 2021-03-10T17:00:00-05:00 Off Campus Location DCMB Seminar Series Livestream / Virtual
DCM&B Tools and Technology Seminar (March 11, 2021 12:00pm) https://events.umich.edu/event/79919 79919-20515552@events.umich.edu Event Begins: Thursday, March 11, 2021 12:00pm
Location: Off Campus Location
Organized By: DCMB Tools and Technology Seminar

Genomic and epigenomic features are captured at a genome-wide level by using high-throughput sequencing technologies. Peak calling is one of the first essential steps in analyzing these features by delineating regions such as open chromatin regions and transcription factor binding sites. Our original peak calling software, F-Seq, has been widely used and shown to be the most sensitive and accurate peak caller for DNase I hypersensitive sites sequencing (DNase-seq) data. However, F-Seq lacks support for user-input control dataset nor reporting test statistics, limiting its ability to capture systematic and experimental biases and accurately estimate background distributions. Here we present an improved version, F-Seq2, which combined the power of kernel density estimation and a dynamic “continuous” Poisson distribution to robustly account for local biases and solve ties when ranking candidate peaks. In F-score and motif distance analysis, we demonstrated the superior performance of F-Seq2 than other competing peak callers used by the ENCODE Consortium on simulated and real ATAC-seq and ChIP-seq datasets. The output of F-Seq2 is suitable for irreproducible discovery rate (IDR) analysis as the test statistics calculated for individual candidate summit and ties are robustly solved.

Tool Link: https://github.com/Boyle-Lab/F-Seq2

URL for remote viewing: https://umich-health.zoom.us/j/94886745590?pwd=LzhLU243K2ZhbXNzU1BJRHQ5V25BZz09

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Livestream / Virtual Fri, 11 Dec 2020 08:08:59 -0500 2021-03-11T12:00:00-05:00 2021-03-11T13:00:00-05:00 Off Campus Location DCMB Tools and Technology Seminar Livestream / Virtual
BME 500 Seminar: George Christ (March 11, 2021 4:00pm) https://events.umich.edu/event/81389 81389-20889819@events.umich.edu Event Begins: Thursday, March 11, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Despite the well-documented capability of skeletal muscle to repair, regenerate, and remodel following injury, there remain a multitude of diseases, disorders, and traumatic injuries that result in irrecoverable loss of muscle structure and function. For example, volumetric muscle loss (VML) injuries are characterized by a degree of composite muscle tissue loss so severe, that it exceeds the native ability of the muscle to repair, thereby resulting in permanent cosmetic and functional deficits to the limbs, neck, or face. These injuries significantly impact both the civilian and military populations. Current treatment for VML injury involves surgical muscle transfer, although these procedures are often associated with both poor engraftment and donor site morbidity, as well as incomplete cosmesis and functional recovery. Not surprisingly, this unmet medical need has stimulated research efforts to develop new technologies for treatment of VML injuries. Recent attention has focused on development of tissue engineering (TE)/regenerative medicine (RM) technologies to provide more effective treatment options for large scale muscle injuries. A variety of preclinical approaches have been tried that include implantation of synthetic and/or natural extracellular matrices/scaffolds/constructs at the site of VML injury, both with and without a cellular component. Extant data indicate that the inclusion of a cellular component generally leads to a greater degree of functional improvement. Consistent with these preclinical results, recent clinical studies for treatment of VML injury, solely with implanted decellularized extracellular matrix scaffolds, have provided evidence for modest functional recovery but with little de novo muscle tissue regeneration at the injury site. More recently, bio-printed tissue engineered constructs and their potential applications to treatment of VML injury have been reported in the literature. While these initial clinical and preclinical observations are encouraging for the TE/RM paradigm, full structural and functional recovery has yet to be achieved, and thus, there remains significant room for therapeutic advancement. To this end, I will describe our highly collaborative efforts to boost development and evaluation of a range of implantable regenerative therapeutics (biomaterials and tissue engineered constructs) in biologically relevant animal models. The overall goal is to increase the efficiency of clinical translation of TE/RM technologies capable of more complete functional recovery following repair of VML injury.

ZOOM LINK: https://umich.zoom.us/j/94405051853

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Lecture / Discussion Mon, 08 Mar 2021 11:13:19 -0500 2021-03-11T16:00:00-05:00 2021-03-11T17:00:00-05:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Genes in Diseases and Symptoms Careers in Health Speaker Series (March 13, 2021 12:00pm) https://events.umich.edu/event/82457 82457-21102176@events.umich.edu Event Begins: Saturday, March 13, 2021 12:00pm
Location: Off Campus Location
Organized By: Genes in Diseases and Symptoms

Our GIDAS Careers in Health speaker series continues with Dr. Carl Koschmann from 12-1pm EST on Saturday, March 13th. If you’re interested, fill out this quick form and we will send the Zoom link.

Link: https://forms.gle/X7DdRsodaNsUtLoF8

Dr. Koschmann focuses on the care of children and young adults with brain tumors. He specializes in the research and treatment of children with high-risk brain tumors such as high-grade glioma and DIPG. His talk will be followed by a Q&A session.

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Lecture / Discussion Tue, 23 Feb 2021 18:46:12 -0500 2021-03-13T12:00:00-05:00 2021-03-13T13:00:00-05:00 Off Campus Location Genes in Diseases and Symptoms Lecture / Discussion Dr. Carl Koschmann Speaker Series Poster
RNA Seminar featuring: James Nuñez, HHMI Hanna Gray Fellow, University of California, San Francisco (March 15, 2021 4:00pm) https://events.umich.edu/event/81286 81286-20881887@events.umich.edu Event Begins: Monday, March 15, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_f8wC8rrJQzuhYzTEXoW69Q


ABSTRACT
General approaches for heritably altering gene expression would enable many discovery and therapeutic efforts. I will present CRISPRoff— a programmable epigenetic memory writer consisting of a single dead Cas9 fusion protein that establishes DNA methylation and repressive histone modifications to turn off transcription. Transient CRISPRoff expression initiates highly specific DNA methylation and gene repression that is maintained through cell division and differentiation of stem cells to neurons. Pairing CRISPRoff with genome-wide screens and analysis of chromatin marks enabled us to explore the rules for heritable silencing. We identify sgRNAs capable of silencing the large majority of genes including those lacking canonical CpG islands (CGIs) and reveal a wide targeting window extending beyond annotated CGIs. Our finding that targeted DNA methylation outside of CGIs leads to memorized gene silencing expands the canonical model of methylation-based silencing and broadly enables diverse applications including genome-wide screens, multiplexed cell engineering, enhancer silencing, and mechanistic exploration of epigenetic inheritance.

KEYWORDS: CRISPR, transcription, epigenetics
Flyer in PDF: https://rna.umich.edu/wp-content/uploads/2021/02/Seminar-Flyer-03152021-Nunez.pdf

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Lecture / Discussion Thu, 18 Feb 2021 09:21:31 -0500 2021-03-15T16:00:00-04:00 2021-03-15T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion James Nunez, Ph.D. UCSF
Innovations in Global Maternal Healthcare Delivery (March 15, 2021 5:00pm) https://events.umich.edu/event/82932 82932-21225228@events.umich.edu Event Begins: Monday, March 15, 2021 5:00pm
Location: Off Campus Location
Organized By: Center for the History of Medicine

Hi UMMS!

NextGen Med and the Society for the History and Philosophy of Medicine are excited to co-host an educational discussion on Monday, March 15th from 5-6PM via Zoom! Please join us for a talk and Q&A, "How Philanthropy Can Catalyze Innovation in Global Public Health: Maternal, Newborn, and Child Health Focuses in the Gates Foundation," with Program Officer Mrs. Anisha Gururaj.

Anisha Gururaj is a Program Officer at the Bill & Melinda Gates Foundation, in the Maternal Newborn Child Health, Discovery & Tools team, where she develops strategy and manages an investment portfolio focused on developing and delivering novel technologies, like digital health, AI, and connected diagnostics, to transform maternal and newborn health across sub-Saharan Africa and South Asia. Previously, she has worked for a wide variety of technology and public health-focused organizations, ranging from the Baltimore city health department to med device startups and large manufacturing companies. She has a B.S. in Chemical-Biological Engineering from MIT and a dual MSc in Global Governance & Diplomacy and Women's Health Sciences from the University of Oxford where she studied as a Rhodes Scholar.

Zoom link here: https://umich.zoom.us/j/93942689324
Meeting ID: 939 4268 9324

Hope to see you there!

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Livestream / Virtual Thu, 11 Mar 2021 12:50:14 -0500 2021-03-15T17:00:00-04:00 2021-03-15T18:15:00-04:00 Off Campus Location Center for the History of Medicine Livestream / Virtual
U-M Injury Prevention Center 2021 Suicide Prevention Summit (March 16, 2021 12:00pm) https://events.umich.edu/event/79634 79634-20436381@events.umich.edu Event Begins: Tuesday, March 16, 2021 12:00pm
Location: Off Campus Location
Organized By: U-M Injury Prevention Center

The University of Michigan Injury Prevention Center has organized a unique event to share the latest evidence-based suicide prevention research, facilitate new collaborations, and explore new ideas for suicide prevention.

Please visit this url for more information: https://www.eventbrite.com/e/the-science-of-suicide-prevention-tickets-128890714597

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Conference / Symposium Tue, 01 Dec 2020 11:14:38 -0500 2021-03-16T12:00:00-04:00 2021-03-16T17:00:00-04:00 Off Campus Location U-M Injury Prevention Center Conference / Symposium Suicide_Prevention_Summit
TSCA @ 5 Years: Opportunities to Act with Foresight (March 16, 2021 7:00pm) https://events.umich.edu/event/82485 82485-21108121@events.umich.edu Event Begins: Tuesday, March 16, 2021 7:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

The University of Michigan M-LEEaD Center is co-sponsoring an event to mark the 5-year anniversary of the bipartisan legislation called the Frank R. Lautenberg Chemical Safety for the 21st Century Act. This reform law was designed to modernize U.S. industrial chemical policy to promote health, but has it lived up to its promise?

Public understanding is limited regarding how exposures to toxic chemicals affect health and how they might be regulated. Unlike pharmaceuticals, industrial and commercial chemicals are rarely tested for safety before they reach the U.S. market. The 1976 TSCA has been widely acknowledged to be a weak and ineffective law, and widespread exposures and harms continue. In the U.S., everyone is exposed to industrial and toxic chemicals, dozens and probably hundreds – well before birth. The amount of chemicals manufactured and imported continues to grow – it is trillions of pounds – and these chemicals remain largely unregulated. At the same time, we have seen an increase in chronic diseases, such as diabetes, autism, and infertility. Not everyone is equally at risk, and a higher burden of disease falls on low wealth communities and communities of color. These health disparities in exposures and health effects are illustrated and exacerbated by COVID.

The amended TSCA gave the U.S. Environmental Protection Agency new requirements and authorities. The public health impact points to the need for the U.S. EPA to fully use its new powers to evaluate all risks from hazardous chemicals and set policies which protect health and are accountable to high-risk communities. Preventive actions are urgently needed.

Watch “THE FOREVER CHEMICALS” documentary (2019, 26 min) at Great Lakes Now then join the March 16 forum. https://www.greatlakesnow.org/fc
“The Forever Chemicals” is an Emmy-winning examination of the impact of PFAS contamination in west Michigan
communities.

LEARN MORE AT OUR LIVE VIRTUAL PANEL DISCUSSION (registration required) on March 16 with Sandra Svoboda, “The Forever Chemicals” co-producer and Great Lakes Now Program Director; Tracey Woodruff, PhD, MPH, Professor, Ob/Gyn, Reproductive Sciences, University of CA-San Francisco; and Justin Onwenu, Environmental Justice Organizer, Sierra Club. Moderated by Patricia Koman, MPP, PhD, Research Investigator, Environmental Health Sciences, University of Michigan with Welcoming remarks from Gilbert S. Omenn, MD, PhD, the Harold T Shapiro Distinguished University Professor of Medicine (also Professor of Computational Medicine & Bioinformatics; Internal Medicine; Human Genetics; and Public Health, Univ of Mich).

REGISTER HERE https://bit.ly/37I2JaU

SPONSORED BY the Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD) • U-M Environmental Health Sciences • Detroit Public Television • Wayne State CURES Center • U-M Sustainable Living Experience • UROP (U-M Undergraduate Research Opportunity Program) • UMIHSA (U-M Industrial Hygiene Students Association) • EHSA (Environmental Health Student Association) • American Chemical Society Outreach Organization • U-M Health Policy Student Association • Ecology Center • Michigan Environmental Justice Coalition • UCSF Program for Reproductive Health and the Environment • UCSF EaRTH Center

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Conference / Symposium Wed, 03 Mar 2021 12:57:09 -0500 2021-03-16T19:00:00-04:00 2021-03-16T20:30:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Conference / Symposium March 16 Panel Discussion: TSCA @ 5 Years
CCMB / DCMB Weekly Seminar Series featuring Sriram Chandrasekaran (Assistant Professor, Biomedical Engineering) (March 17, 2021 4:00pm) https://events.umich.edu/event/82825 82825-21179592@events.umich.edu Event Begins: Wednesday, March 17, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract: Drug combinations have the potential to greatly expand our pharmacopeia while reducing both cost and drug resistance. Yet the current drug-discovery approach is unable to screen the astronomical number of possible combinations in different cell types and does not account for the complex environment inside the body. We have developed AI tools - INDIGO and MAGENTA - that predict the efficacy of drug combinations based on the properties of the drugs, the pathogen, and the infection environment. We are also using modeling to identify drugs that work in synergy with the host immune system. Using INDIGO and MAGENTA, we have identified highly synergistic combinations of repurposed drugs to treat drug resistant infections including Tuberculosis, the deadliest bacterial infection. INDIGO also accurately predicts the outcome of past clinical trials of drug combinations. Our ultimate goal is to create a personalized approach to treat infections using AI.
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Biography: Chandrasekaran received his bachelor’s degree in Biotechnology from Anna University in 2008, and a PhD in Biophysics from the University of Illinois at Urbana-Champaign in 2013. He worked at Harvard University and MIT as a Harvard Junior Fellow between 2013 and 2016 and became an Assistant Professor at UM in 2017. His lab develops systems biology algorithms for drug discovery. Computer models from his lab like INDIGO and MAGENTA are being used to design effective therapies against drug resistant pathogens. His lab also develops systems biology algorithms to understand metabolic regulation. The approaches that they have created (PROM, ASTRIX, DFA, EGEM and GEMINI) perform complementary functions in modeling of metabolic and regulatory networks. Chandrasekaran’s research has been published in Cell, Genome Biology, mBio, and PNAS. For his work, Chandrasekaran previously received the 2013 Harvard Junior Fellowship, the 2011 Howard Hughes Medical Institute (HHMI) International Predoctoral Fellowship, the 2014 William Milton Fund award, 2018 UM Precision Health Investigator Award, and the 2018 Distinguished Young Investigator Award from the AICHE COBRA society.


https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Fri, 05 Mar 2021 14:44:14 -0500 2021-03-17T16:00:00-04:00 2021-03-17T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual Sriram Chandrasekaran, PhD (Assistant Professor, Biomedical Engineering)
DCM&B Tools and Technology Seminar (March 18, 2021 12:00pm) https://events.umich.edu/event/79920 79920-20515553@events.umich.edu Event Begins: Thursday, March 18, 2021 12:00pm
Location: Off Campus Location
Organized By: DCMB Tools and Technology Seminar

Tool Link: WIZARD: https://github.com/ML4LHS/wizard
Tool Link: Clinspacy: https://github.com/ML4LHS/clinspacy
Tool Link: Runway: https://github.com/ML4LHS/runway

URL for remote viewing: https://umich-health.zoom.us/j/94886745590?pwd=LzhLU243K2ZhbXNzU1BJRHQ5V25BZz09

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Livestream / Virtual Fri, 11 Dec 2020 08:11:56 -0500 2021-03-18T12:00:00-04:00 2021-03-18T13:00:00-04:00 Off Campus Location DCMB Tools and Technology Seminar Livestream / Virtual
The Woll Family Speaker Series on Health, Spirituality and Religion presents (March 18, 2021 12:00pm) https://events.umich.edu/event/82727 82727-21169586@events.umich.edu Event Begins: Thursday, March 18, 2021 12:00pm
Location: Off Campus Location
Organized By: The University of Michigan Medical School Program on Health, Spirituality and Religion

The Woll Family Speaker Series on Health, Spirituality and Religion presents

Christian Alch, MD, House Officer, Department of Internal Medicine, "Barriers to Addressing the Spiritual and Religious Needs of Patients and Families in the Intensive Care Unit: A Qualitative Study of Critical Care Physicians"

Abbass Berjaoui, Third Year Medical Student, Ruth Bishop, Third Year Medical Student, Elie Ellenberg, Fourth Year Medical Student, "Assessing the Spiritual Needs of Patients Awaiting Heart Transplantation" (Ruth Bishop to present)

Nabeel Salka, Fourth Year Medical Student, "Exploring Physician Identity from an Islamic and Contemporary Western Perspective"

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Workshop / Seminar Thu, 04 Mar 2021 09:14:06 -0500 2021-03-18T12:00:00-04:00 2021-03-18T13:00:00-04:00 Off Campus Location The University of Michigan Medical School Program on Health, Spirituality and Religion Workshop / Seminar
BME 500 Seminar: Daniel Rueckert (March 18, 2021 4:00pm) https://events.umich.edu/event/81390 81390-20889820@events.umich.edu Event Begins: Thursday, March 18, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Zoom Link: https://cwru.zoom.us/webinar/register/WN_tmHJ7ArQRyO01NN6SfYYtg

Hosted by Dr. Frederick Epstein

Seminar Abstract:
The talk will focus on the use of deep learning techniques for the discovery and quantification of clinically useful information from medical images. The talk will describe how deep learning can be used for the reconstruction of medical images from undersampled data, image super-resolution, image segmentation and image classification. It will also show the clinical utility of applications of deep learning for the interpretation of medical images in applications such as brain tumour segmentation, cardiac image analysis and applications in neonatal and fetal imaging. Finally, it will be discussed how deep learning may change the future of medical imaging. https://openbme.org/

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Lecture / Discussion Mon, 15 Mar 2021 14:07:10 -0400 2021-03-18T16:00:00-04:00 2021-03-18T17:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Michigan India Conference (March 19, 2021 9:00am) https://events.umich.edu/event/82608 82608-21137866@events.umich.edu Event Begins: Friday, March 19, 2021 9:00am
Location: Off Campus Location
Organized By: Michigan India Conference

Have you heard the good news? The annual Michigan India Conference is back, and we’re going virtual for 2021.

We hope to see you there. We have a series of influential speakers you won’t want to miss! The theme for this year's conference is Stability & Change, so we have brought you the best decision-makers and thinkers surrounding India's government, India's economy and the Indian consumer. Get a chance to learn about the latest trends, opportunities, and maybe even a chance to network with some of India’s prestigious figures.

The Michigan India Conference gives business leaders, students, alumni, policymakers, and anyone interested, a chance to learn more about what drives this dynamic economy. Whether you are interested in doing business in India or want to learn more about policy and government, the Michigan India Conference is open to all. We hope you will join us.

Take advantage of our first fully-digital conference!
Register today: https://forms.gle/ug5R9KMKs1dXu28bA

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Conference / Symposium Tue, 09 Mar 2021 13:06:47 -0500 2021-03-19T09:00:00-04:00 2021-03-19T10:00:00-04:00 Off Campus Location Michigan India Conference Conference / Symposium Michigan India Conference
Project Management Certification (March 21, 2021 12:00pm) https://events.umich.edu/event/80730 80730-20779512@events.umich.edu Event Begins: Sunday, March 21, 2021 12:00pm
Location: Off Campus Location
Organized By: Tauber Institute for Global Operations

Once again, the Tauber Institute, in conjunction with the International Project Management Association (IPMA), is sponsoring a Project Management certification class and exam for graduate business and engineering students and staff.

In order to participate, you will need to reflect upon a project management experience (for example: a work project, an engineering design experience/senior capstone, Ross' MAP project, Tauber team project, etc). If you cannot make it to the classes (due to project travel, MAP, or other another class), the sessions will be recorded. Homework (mastery verification) will be required after each session.

The cost to an individual to take the exam is normally $595, however, Tauber is offering the exam at a substantial discount to non-Tauber students:
$500 for U-M alumni or public
$400 for U-M students, U-M employees, or Tauber alumni
$200 for Tauber Institute students

Certification is valid for 5 years. Three certification classes will be taught by Professor Eric Svaan on the following dates:

Sunday, March 21 (noon - 4:30 pm)
Sunday, March 28 (noon - 4:30 pm)
Sunday, April 18 (noon - 4:30 pm)

The certification exam, administered by IPMA-USA is scheduled for May 12, 2021 (11:00 am) virtually. Successfully passing the exam will yield IPMA's Level D certification (Certified Project Management Associate).

Since 2013, all students who have taken the exam have passed!

Project Management is a powerful skill set to have in your toolbox as you look for full-time employment!

REGISTRATION: Please register through iMpact by clicking here:
https://www.bus.umich.edu/Conferences/Project-Management-Certification-2021/Default.aspx

NOTE: The non-refundable fees:
$500 for non-Tauber students, U-M alumni, or public
$400 for U-M students, U-M employees, or Tauber alumni
$200 for Tauber Institute students

HOSTED BY: Tauber Institute for Global Operations. For questions about this event, please contact tauberinstitute@umich.edu or visit tauber.umich.edu.

What is IPMA Level D® (Certified Project Management Associate)? The IPMA Level D is an internationally recognized entry-level qualification in the area of project management. This designation, which demonstrates the individual's ability to understand the basics of project management, is similar to the exam-oriented, knowledge-based certifications of other major Project Management associations. For many, Level D® is the first step towards a professional project or program manager role. It is the first step in a sequence (C, B and A) to be earned by demonstration of success in larger PM responsibility sets.

For more information,
Visit tauber.umich.edu or call 734-647-1333
Connect via email to Diana Crossley dianak@umich.edu

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Class / Instruction Tue, 19 Jan 2021 12:27:23 -0500 2021-03-21T12:00:00-04:00 2021-03-21T16:30:00-04:00 Off Campus Location Tauber Institute for Global Operations Class / Instruction Certificate photo
Concussion Prevention: A Multi-Disciplinary Approach (March 24, 2021 11:30am) https://events.umich.edu/event/83111 83111-21272914@events.umich.edu Event Begins: Wednesday, March 24, 2021 11:30am
Location: Off Campus Location
Organized By: U-M Office of Research

Please join the Michigan Exercise & Sport Science Initiative and the University of Michigan Concussion Center on Wednesday, March 24, 2021, at 11:30am for a panel discussion focusing on concussion prevention. You will learn concussion prevention methods from experts in athlete conditioning, equipment manufacturing, and sports policy at the state, national, and international levels.

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Lecture / Discussion Wed, 17 Mar 2021 10:43:41 -0400 2021-03-24T11:30:00-04:00 2021-03-24T12:30:00-04:00 Off Campus Location U-M Office of Research Lecture / Discussion Concussion
Where Do We Go From Here: Body Politics & Movement Towards Racial Empowerment (March 24, 2021 12:00pm) https://events.umich.edu/event/82828 82828-21179596@events.umich.edu Event Begins: Wednesday, March 24, 2021 12:00pm
Location: Off Campus Location
Organized By: School of Kinesiology

Please join us for the last event in our series addressing the theme: "Where Do We Go From Here: Body Politics and Movement Towards Racial Empowerment."

This event will consist of a panel featuring scholars and medical, mental health, and fitness experts discussing movement, and physical and mental wellness/well-being as ways of combatting the body politics of racism. The event will include panelists’ demonstrations and audience participation.

If you'd like to join along with the Afrobeats dance demonstration (and we hope you do), please wear comfortable clothes and use a space where you have room to move. All ages and abilities are welcome; no experience needed!

--Abigail Eiler, LMSW, MSW, QMHP: Clinical Assistant Professor, U-M School of Social Work; Director, Athletics Counseling, U-M Athletics; Chair, Mental Health & Wellness Cabinet, Big Ten Conference

--Chiamaka Ukachukwu, MS: PhD Candidate (Specializing in Cardiovascular Electrophysiology), U-M Department of Pharmacology; Afrobeats Dance Instructor, U-M Recreational Sports

--Dr. Kamaria Washington, DPT: Physical Therapist (Specializing in Pelvic Floor Concerns), Therapeutic Associates Bethany Physical Therapy (Portland, OR)

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Well-being Wed, 17 Mar 2021 17:58:46 -0400 2021-03-24T12:00:00-04:00 2021-03-24T13:30:00-04:00 Off Campus Location School of Kinesiology Well-being U-M Health Sciences - Where Do We Go From Here: Body Politics & Movement Towards Racial Empowerment
James S. Jackson’s Continuing Legacy and Contributions to Social and Behavioral Research on Black Americans (March 24, 2021 1:00pm) https://events.umich.edu/event/82484 82484-21108104@events.umich.edu Event Begins: Wednesday, March 24, 2021 1:00pm
Location: Off Campus Location
Organized By: Institute for Social Research

ISR Insights Speaker Series – James S. Jackson’s Continuing Legacy and Contributions to Social and Behavioral Research on Black Americans

Wednesday, March 24, 1pm EST. https://umich.zoom.us/j/99879554198

Panelists: Robert Taylor (Harold R Johnson Endowed Professor of Social Work, Sheila Feld Collegiate Professor of Social Work, School of Social Work, and Faculty Associate, RCGD); Belinda Tucker (Professor Emerita of Psychiatry & Biobehavioral Sciences, and the Special Liaison for Faculty Development, UCLA); and Phillip Bowman (Professor, Higher and Postsecondary Education at the U-M International Institute)

Join Robert Taylor, Belinda Tucker, and Phillip Bowman for a panel discussion on the continuing legacy and contributions of James S. Jackson.

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Lecture / Discussion Wed, 24 Feb 2021 16:45:04 -0500 2021-03-24T13:00:00-04:00 2021-03-24T14:00:00-04:00 Off Campus Location Institute for Social Research Lecture / Discussion event flyer
CCMB / DCMB Weekly Seminar Series Featuring Duncan K. Ralph (Fred Hutchinson Cancer Research Center) (March 24, 2021 4:00pm) https://events.umich.edu/event/82733 82733-21169592@events.umich.edu Event Begins: Wednesday, March 24, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract: Antibodies are an integral part of the adaptive immune response, and are a critical component of both vaccine-induced and naturally-acquired immunity. The development of deep sequencing approaches in recent years has allowed us to sample a significant fraction of the diverse repertoire of B cell receptor sequences from which antibodies are made. These sequences encode a wealth of information on the somatic rearrangement and evolutionary processes that determine the contours of our antibody repertoires, and thus our ability to respond appropriately to pathogens and vaccines. Extracting this information, however, requires a careful inference approach across several different analysis steps. I will describe the computational approaches that we have taken to solving these problems, which constitute the partis software package, and describe their application in several projects, including HIV and Dengue data.

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Biography: Duncan attended the University of California at Santa Cruz for his undergraduate studies in physics, completing his thesis on energy transport in condensed matter theory in 2005. He completed his PhD at the Massachusetts Institute of Technology in 2014, working on the Large Hadron Collider at the European particle physics laboratory (CERN). His thesis described the observation of Higgs boson decays to four leptons. Since 2014, he has worked in Frederick Matsen’s lab at the Fred Hutchinson Cancer Research Center, first as a postdoctoral researcher and more recently as a staff scientist, writing new computational methods for the analysis of B cell receptor deep sequencing data.

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Thu, 04 Mar 2021 11:20:24 -0500 2021-03-24T16:00:00-04:00 2021-03-24T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual
Designing for Impact in Global Health (March 24, 2021 5:00pm) https://events.umich.edu/event/82821 82821-21179589@events.umich.edu Event Begins: Wednesday, March 24, 2021 5:00pm
Location: Off Campus Location
Organized By: Center for Global Health Equity

Please join us for the next seminar for the UM Center for Global Health Equity: Designing for Impact in Global Health.

Panelists include:
Kathleen Sienko, College of Engineering
Paul Clyde, William Davidson Institute
Rocky Oteng, School of Medicine
Kentaro Toyama, School of Information
Grace Burleson, College of Engineering
David Green, Social Entrepreneur
Jesse Austin-Breneman, College of Engineering

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Workshop / Seminar Fri, 05 Mar 2021 14:12:00 -0500 2021-03-24T17:00:00-04:00 2021-03-24T18:30:00-04:00 Off Campus Location Center for Global Health Equity Workshop / Seminar Panelists
5th Annual RNA Symposium, "Processing RNA" (March 25, 2021 11:00am) https://events.umich.edu/event/80161 80161-20572609@events.umich.edu Event Begins: Thursday, March 25, 2021 11:00am
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

FOR MORE DETAILS & ABSTRACTS VISIT: https://rna.umich.edu/2021-symposium/

Thursday, March 25, 2021
11:00 / Welcome
11:05 / KEYNOTE 1: Tracy Johnson, UCLA, “RNA Splicing, Chromatin Modification, and the Coordinated Control of Gene expression”
12:00 / Short break
12:10 / KEYNOTE 2: Kevin Weeks, UNC, “Structure-Based Discovery of New Functions in Large RNAs”
1:05 / Data Blitz: Cathy Smith, Daniel Peltier, Yan Zhang
1:35 / KEYNOTE 3: Feng Zhang, MIT, “Exploration of Biological Diversity to Discover Novel Molecular Technologies”
2:30 / Close Day 1

Friday, March 26, 2021
11:00 / Welcome
11:05 / KEYNOTE 4: Brenda Bass, University of Utah, “Distinguishing self and non-self dsRNA in vertebrates and invertebrates”
12:00 / Short break
12:10 / KEYNOTE 5: Christopher Lima, Sloan-Kettering Institute, “Mechanisms that target RNA for destruction”
1:05 / Data Blitz: Meredith Purchal, Adrien Chauvier, Shannon Wright
1:35 / Panel discussion with keynote speakers
2:30 / Close Day 2

Liveblogging by MiSciWriters! https://misciwriters.com/

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Lecture / Discussion Tue, 23 Mar 2021 15:03:26 -0400 2021-03-25T11:00:00-04:00 2021-03-25T14:30:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion 5th Annual RNA Symposium
DCM&B Tools and Technology Seminar (March 25, 2021 12:00pm) https://events.umich.edu/event/82051 82051-21012687@events.umich.edu Event Begins: Thursday, March 25, 2021 12:00pm
Location: Off Campus Location
Organized By: DCMB Tools and Technology Seminar

URL for remote viewing: https://umich-health.zoom.us/j/94886745590?pwd=LzhLU243K2ZhbXNzU1BJRHQ5V25BZz09

(please note that this session will not be recorded)

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Workshop / Seminar Tue, 23 Mar 2021 17:42:45 -0400 2021-03-25T12:00:00-04:00 2021-03-25T13:00:00-04:00 Off Campus Location DCMB Tools and Technology Seminar Workshop / Seminar
LHS Collaboratory March Session (March 25, 2021 12:00pm) https://events.umich.edu/event/82008 82008-21006745@events.umich.edu Event Begins: Thursday, March 25, 2021 12:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Speakers Stefan Boes, PhD and Sarah Mantwill, PhD from the university of Lucerne will discuss the Swiss Learning Health System.

Promoting and supporting uptake of evidence and evidence-informed decision-making in health-systems related policy and practice is a challenge. In Switzerland, the need to address this matter has been increasingly emphasized by different actors in the health system. In particular, the lack of comprehensive coordination efforts in the field of health services research, and subsequent knowledge translation activities, has been stressed. In response, the Swiss Learning Health System (SLHS) was established as a nationwide project in 2017, currently involving 10 academic partner institutions. One of the overarching objectives of the SLHS is to bridge research, policy, and practice by providing an infrastructure that supports learning cycles by: continuously identifying issues relevant to the Swiss health system, systemizing relevant evidence, presenting potential courses of action, and revising and reshaping responses. Key features of learning cycles in the SLHS include the development of policy/evidence briefs that serve as a basis for stakeholder dialogues with actors from research, policy and practice. Issues that are identified to be further pursued are monitored for potential implementation and eventually evaluated to inform new learning cycles and to support continuous learning within the system.

Dr. Boes and Dr. Mantwill will provide an overview of the SLHS and its key features, as well as its capacity building efforts to train young researchers in the field of learning health systems, and the development of a centralized metadata repository in support of creating a sufficient large evidence basis to support learning cycles in the Swiss health system. Further, they will discuss lessons learned from the past and the newest developments of the SLHS in light of a second funding phase supported by the Swiss government.

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Livestream / Virtual Thu, 25 Feb 2021 23:57:27 -0500 2021-03-25T12:00:00-04:00 2021-03-25T13:30:00-04:00 Off Campus Location Department of Learning Health Sciences Livestream / Virtual LHS Collaboratory Logo
BME 500 Seminar: Warren L. Grayson (March 25, 2021 4:00pm) https://events.umich.edu/event/81391 81391-20889821@events.umich.edu Event Begins: Thursday, March 25, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Tissue engineering provides a viable means of regenerating bone and skeletal muscle tissues following injuries that lead to large volumetric defects. Our lab has developed advanced biomaterial and stem cell-based approaches to promote functional recovery following volumetric muscle loss and critical-sized craniofacial bone injuries. This presentation will focus on three areas of ongoing research: (1) I will present our lab’s efforts to regenerate vascularized and innervated skeletal muscle in mice including our recent studies using human pluripotent stem cells. (2) Recently, our group completed a study focused on designing biomaterials to guide bone regeneration in situ in minipigs using intraoperative protocols for combining autologous stem cells with 3D-printed scaffolds. (3) Understanding the interaction between vascular cells and osteoprogenitors is critical for developing effective treatment methods. I will describe recent studies in which we developed a quantitative imaging platform for characterizing the spatial relationships between cell populations in the native murine calvarium. https://openbme.org/

ZOOM LINK TO REGISTER: https://cwru.zoom.us/webinar/register/WN_Kgyl3yf4TcKvlk9xNKluhA

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Lecture / Discussion Sun, 21 Mar 2021 17:46:23 -0400 2021-03-25T16:00:00-04:00 2021-03-25T17:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Michigan India Conference (March 26, 2021 9:00am) https://events.umich.edu/event/82608 82608-21137867@events.umich.edu Event Begins: Friday, March 26, 2021 9:00am
Location: Off Campus Location
Organized By: Michigan India Conference

Have you heard the good news? The annual Michigan India Conference is back, and we’re going virtual for 2021.

We hope to see you there. We have a series of influential speakers you won’t want to miss! The theme for this year's conference is Stability & Change, so we have brought you the best decision-makers and thinkers surrounding India's government, India's economy and the Indian consumer. Get a chance to learn about the latest trends, opportunities, and maybe even a chance to network with some of India’s prestigious figures.

The Michigan India Conference gives business leaders, students, alumni, policymakers, and anyone interested, a chance to learn more about what drives this dynamic economy. Whether you are interested in doing business in India or want to learn more about policy and government, the Michigan India Conference is open to all. We hope you will join us.

Take advantage of our first fully-digital conference!
Register today: https://forms.gle/ug5R9KMKs1dXu28bA

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Conference / Symposium Tue, 09 Mar 2021 13:06:47 -0500 2021-03-26T09:00:00-04:00 2021-03-26T10:00:00-04:00 Off Campus Location Michigan India Conference Conference / Symposium Michigan India Conference
5th Annual RNA Symposium, "Processing RNA" (March 26, 2021 11:00am) https://events.umich.edu/event/80161 80161-20572610@events.umich.edu Event Begins: Friday, March 26, 2021 11:00am
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

FOR MORE DETAILS & ABSTRACTS VISIT: https://rna.umich.edu/2021-symposium/

Thursday, March 25, 2021
11:00 / Welcome
11:05 / KEYNOTE 1: Tracy Johnson, UCLA, “RNA Splicing, Chromatin Modification, and the Coordinated Control of Gene expression”
12:00 / Short break
12:10 / KEYNOTE 2: Kevin Weeks, UNC, “Structure-Based Discovery of New Functions in Large RNAs”
1:05 / Data Blitz: Cathy Smith, Daniel Peltier, Yan Zhang
1:35 / KEYNOTE 3: Feng Zhang, MIT, “Exploration of Biological Diversity to Discover Novel Molecular Technologies”
2:30 / Close Day 1

Friday, March 26, 2021
11:00 / Welcome
11:05 / KEYNOTE 4: Brenda Bass, University of Utah, “Distinguishing self and non-self dsRNA in vertebrates and invertebrates”
12:00 / Short break
12:10 / KEYNOTE 5: Christopher Lima, Sloan-Kettering Institute, “Mechanisms that target RNA for destruction”
1:05 / Data Blitz: Meredith Purchal, Adrien Chauvier, Shannon Wright
1:35 / Panel discussion with keynote speakers
2:30 / Close Day 2

Liveblogging by MiSciWriters! https://misciwriters.com/

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Lecture / Discussion Tue, 23 Mar 2021 15:03:26 -0400 2021-03-26T11:00:00-04:00 2021-03-26T14:30:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion 5th Annual RNA Symposium
CCMB / DCMB Weekly Seminar (March 31, 2021 4:00pm) https://events.umich.edu/event/83395 83395-21369780@events.umich.edu Event Begins: Wednesday, March 31, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

Large, deeply phenotyped cohorts are reshaping the world of environmental epidemiology. Two such “big data” resources that are reshaping how we understand environmental health are electronic health records and human cohorts with genome-wide molecular phenotyping. Each provides a unique perspective that is moving the field closer towards “personalized” insights into environmental health risks. Here I will talk about a series of studies which utilize electronic health records and molecularly phenotyped cohorts to investigate vulnerable populations, gene-environment interactions, and epigenetic biomarkers of environmental sensitivity. Together these studies are helping us to understand environmental health risks in a new light.

Short bio:

Dr. Cavin Ward-Caviness is a Principal Investigator in the Public Health and Integrated Toxicology Division of the US Environmental Protection Agency. With a background in computational biology and environmental epidemiology, Dr. Ward-Caviness seeks to understand the environmental factors which influence health in vulnerable populations and the molecular mechanisms that influence environmental health risks. The Ward-Caviness lab uses a variety of “big data” approaches, and Dr. Ward-Caviness is the PI of the EPA CARES research resource, which allows researchers to study environmental health effects in vulnerable patient populations, e.g. individuals with heart failure, using large electronic health record databases. Dr. Ward-Caviness is also interested in how epigenetics and metabolomics can serve as an early indicator of adverse health effects from chemical and social environmental exposures and in particular how molecular biomarkers can give us insight into how the environment may accelerate the aging process and thus contribute to chronic disease. By integrating molecular and clinical data, Dr. Ward-Caviness seeks to understand environmental health as a way to advance personalized medicine and reduce health disparities.

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Mon, 29 Mar 2021 15:15:11 -0400 2021-03-31T16:00:00-04:00 2021-03-31T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual
COVID-19: Reflections and vision for the future (March 31, 2021 5:30pm) https://events.umich.edu/event/82941 82941-21227210@events.umich.edu Event Begins: Wednesday, March 31, 2021 5:30pm
Location: Off Campus Location
Organized By: Trotter Multicultural Center

This March marks the one year after the pandemic.

Join the Trotter Distinguished Leadership Series as we host social demographer, professor of Public Policy & Health Management and Policy, and Associate Dean for Academic Affairs, Dr. Paula Lantz for COVID-19: Reflections and vision for the future. Award-winning science journalist and author, Nicholas St. Fleur, will be moderating and guiding us through a discussion that reflects on the impacts of the pandemic on local community health and policy, and explores what comes next.

Trotter Multicultural Center looks forward to seeing you on March 31st from 5:30-7 PM. Register at: myumi.ch/9obEl

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Lecture / Discussion Tue, 23 Mar 2021 14:38:11 -0400 2021-03-31T17:30:00-04:00 2021-03-31T19:00:00-04:00 Off Campus Location Trotter Multicultural Center Lecture / Discussion Image of event flyer
DCM&B Tools and Technology Seminar (April 1, 2021 12:00pm) https://events.umich.edu/event/79922 79922-20515555@events.umich.edu Event Begins: Thursday, April 1, 2021 12:00pm
Location: Off Campus Location
Organized By: DCMB Tools and Technology Seminar

Many protein function databases are built on automated or semi-automated curations and can contain various annotation errors. The correction of such misannotations is critical to improving the accuracy and reliability of the databases. We proposed a new approach to detect potentially incorrect Gene Ontology (GO) annotations by comparing the ratio of annotation rates (RAR) for the same GO term across different taxonomic groups, where those with a relatively low RAR usually correspond to incorrect annotations. As an illustration, we applied the approach to 20 commonly studied species in two recent UniProt-GOA releases and identified 250 potential misannotations in the 2018-11-6 release, where only 25% of them were corrected in the 2019-6-3 release. Importantly, 56% of the misannotations are “Inferred from Biological aspect of Ancestor (IBA)”, i.e. reviewed computational annotations based on phylogenetic analysis. This is in contrast to previous observations that attributed misannotations mainly to “Inferred from Sequence or structural Similarity (ISS)”, probably reflecting an error source shift due to the new developments of function annotation databases. The results demonstrated a simple but efficient misannotation detection approach that is useful for developing taxonomic constraints in large-scale comparative protein function studies.

Tool Link: https://zhanglab.ccmb.med.umich.edu/RAR

URL for remote viewing: https://umich-health.zoom.us/j/94886745590?pwd=LzhLU243K2ZhbXNzU1BJRHQ5V25BZz09

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Livestream / Virtual Fri, 11 Dec 2020 08:17:31 -0500 2021-04-01T12:00:00-04:00 2021-04-01T13:00:00-04:00 Off Campus Location DCMB Tools and Technology Seminar Livestream / Virtual
BME 500 Seminar: Tim Downing (April 1, 2021 4:00pm) https://events.umich.edu/event/81392 81392-20889822@events.umich.edu Event Begins: Thursday, April 1, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

https://openbme.org/

ZOOM LINK TO REGISTER: https://cwru.zoom.us/webinar/register/WN_iY_PMZevQwWRYkMyK7ifzA

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Lecture / Discussion Fri, 26 Mar 2021 14:01:59 -0400 2021-04-01T16:00:00-04:00 2021-04-01T17:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
BME Seminar: Synthetic Genome Engineering for Cell and Tissue Engineering (April 1, 2021 4:00pm) https://events.umich.edu/event/80692 80692-20783435@events.umich.edu Event Begins: Thursday, April 1, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Title: Synthetic Genome Regulation for Cell and Tissue Engineering

Abstract: Molecular heterogeneity is emerging as a critical feature of multicellular life. While single-cell analyses have revealed the existence of cell-to-cell variation in the levels and activities of the molecules responsible for gene regulation, the source of such variation is still poorly understood. The Downing Lab studies how genome replication contributes to epigenetic heterogeneity across stem cell populations. We recently developed a new sequencing method (Repli-Bisulfite Sequencing) that enables analysis of DNA methylation within newly replicated strands of DNA over time. Using this method, we discovered that much of the methylation heterogeneity observed within human embryonic stem cells (hESCs) is temporal in nature and associated with DNA replication. Here, we employ bioinformatic analyses to explore how properties of post-replication DNA methylation dynamics relate to well-established features of the genome and the broader chromatin landscape. Our findings reveal that unique patterns of methylome replication associate with distal regulatory regions throughout the genome, enrich for cytosine residues dynamically methylated across cell types, and coincide with the location of stem cell-specific transcription factor binding and chromatin architectures. We also find correlations between sub-cell cycle kinetics in DNA methylation and the divergence of bulk methylation patterns observed during multiple cell generations and natural aging. Taken together, our studies suggest that (epi)genome replication may act as an important source of (temporal) regulatory variation in hESCs while, simultaneously, conferring susceptibility to epigenetic drift throughout the human lifespan. Our lab is also interested in understanding how the chemical and biophysical microenvironment influences adult cell behavior and phenotype through epigenetic gene regulatory mechanisms. We hope to use this information in the design of next-generation biomaterials. The second part of this presentation will describe how focal adhesions and cell-mediated forces contribute to inefficiencies observed during the acquisition of stemness from somatic cell states.



Biography: Tim Downing has been on the faculty at UC Irvine since 2016 and holds a primary appointment in the Department of Biomedical Engineering. He also holds a courtesy appointment in the Department of Microbiology & Molecular Genetics. Tim received his B.S. in Chemical Engineering in 2008 from Northwestern University and Ph.D. in Bioengineering from UC Berkeley in 2013 under the mentorship of Dr. Song Li. As a Ford Foundation and UNCF/Merck Fellow, Tim completed his postdoctoral training in stem cell epigenomics with Dr. Alexander Meissner at Harvard University and the Broad Institute (Cambridge, Massachusetts). The Downing Lab focuses on understanding gene regulation during tissue development, regeneration, and disease progression. Building on this information, the lab also aims to develop molecular tools and biomaterials to synthetically regulate the epigenome for better control over cell fate and behavior. Tim is a 2019 NIH (DP2) New Innovator Award recipient and a 2020 recipient of the “Rising Star” Award from the Cellular and Molecular Bioengineering (CMBE) Special Interest Group within the Biomedical Engineering Society (BMES).

Zoom Registration Link: https://cwru.zoom.us/webinar/register/WN_iY_PMZevQwWRYkMyK7ifzA

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Workshop / Seminar Thu, 25 Mar 2021 13:09:17 -0400 2021-04-01T16:00:00-04:00 2021-04-01T17:00:00-04:00 Off Campus Location Biomedical Engineering Workshop / Seminar Dr. Timothy L. Downing, UC Irvine
Health Professions Education (HPE) Day 2021 Virtual Event (April 6, 2021 8:00am) https://events.umich.edu/event/79926 79926-20515558@events.umich.edu Event Begins: Tuesday, April 6, 2021 8:00am
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Dr. Umland is Co-Director and Associate Provost of Interprofessional Practice and Education at Jefferson Center for Interprofessional Practice and Education (JCIPE).
There will be a poster session after the plenary/Q&A. Check the website for more information about abstract/poster submission.
HPE Day is an opportunity to share and disseminate scholarly efforts, completed or in progress, and to spark the dialogue required to synergize our work. This event will bring together educational scholars, practitioners, researchers and students to share best practices and explore opportunities for collaboration and innovation. The day’s highlights will include sharing of our initial efforts in interprofessional education and collaborative care and discussion of opportunities for the growth of collaboration across the health science schools and the broader campus community.

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Conference / Symposium Fri, 11 Dec 2020 10:06:56 -0500 2021-04-06T08:00:00-04:00 2021-04-06T13:00:00-04:00 Off Campus Location Department of Learning Health Sciences Conference / Symposium Health Professions Education Day 2021 Virtual Event
CCMB / DCMB Weekly Seminar Series (April 7, 2021 4:00pm) https://events.umich.edu/event/83241 83241-21320453@events.umich.edu Event Begins: Wednesday, April 7, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract: More than 3,000 new Marine recruits were studied prospectively during their initial Marine-mandated two-week quarantine and their subsequent basic training at Parris Island. The COVID Health Action Response for Marines (CHARM) studied completed 20,000 study visits and obtained more than 70,000 biosamples including pre- to post- SARS-CoV-2 infections in more than 1000 recruits. Serological, transcriptomic, and epigenetic analyses identify the response signature to SARS-CoV-2 infection in these largely asymptomatic young adults. Phylogenetic analysis and modeling provide insight into epidemiology and guidance for public health measures.

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Specialty: Neurology

Research Topics: Addiction, Apoptosis/Cell Death, Basal Ganglia, Bioinformatics, Brain, Cellular Immunity, Cerebral Cortex, Mathematical and Computational Biology, Multiple Sclerosis, Neuro-degeneration/protection, Receptors, Reproductive Biology, Signal Transduction, Theoretical Biology, Vaccine Development, Viruses and Virology

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Tue, 23 Mar 2021 11:23:58 -0400 2021-04-07T16:00:00-04:00 2021-04-07T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual
What’s Next? How the COVID-19 Vaccines Can Change Our Lives (April 8, 2021 9:30am) https://events.umich.edu/event/83403 83403-21369801@events.umich.edu Event Begins: Thursday, April 8, 2021 9:30am
Location: Off Campus Location
Organized By: School of Public Health

Join infectious disease experts from the University of Michigan School of Public Health and Michigan Medicine for a panel discussion on the COVID-19 vaccines and what we can expect in the weeks and months ahead. The panel will include:

Dr. Arnold Monto, Professor of Epidemiology, University of Michigan School of Public Health
Dr. Sandro Cinti, Clinical Professor of Infectious Diseases, Michigan Medicine and Ann Arbor VA Health System
Dr. Laraine Washer, Clinical Associate Professor of Infectious Diseases, Michigan Medicine
Moderated by: Dr. Emily Martin, Associate Professor of Epidemiology, University of Michigan School of Public Health

* This event is free and open to the public but registration is required. https://sph.umich.edu/events/event.php?ID=8842

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Livestream / Virtual Mon, 29 Mar 2021 17:12:47 -0400 2021-04-08T09:30:00-04:00 2021-04-08T10:30:00-04:00 Off Campus Location School of Public Health Livestream / Virtual Event promotion graphic
What’s Next? How the COVID-19 Vaccines Can Change Our Lives (April 8, 2021 9:30am) https://events.umich.edu/event/83403 83403-21369802@events.umich.edu Event Begins: Thursday, April 8, 2021 9:30am
Location: Off Campus Location
Organized By: School of Public Health

Join infectious disease experts from the University of Michigan School of Public Health and Michigan Medicine for a panel discussion on the COVID-19 vaccines and what we can expect in the weeks and months ahead. The panel will include:

Dr. Arnold Monto, Professor of Epidemiology, University of Michigan School of Public Health
Dr. Sandro Cinti, Clinical Professor of Infectious Diseases, Michigan Medicine and Ann Arbor VA Health System
Dr. Laraine Washer, Clinical Associate Professor of Infectious Diseases, Michigan Medicine
Moderated by: Dr. Emily Martin, Associate Professor of Epidemiology, University of Michigan School of Public Health

* This event is free and open to the public but registration is required. https://sph.umich.edu/events/event.php?ID=8842

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Livestream / Virtual Mon, 29 Mar 2021 17:12:47 -0400 2021-04-08T09:30:00-04:00 2021-04-08T10:30:00-04:00 Off Campus Location School of Public Health Livestream / Virtual Event promotion graphic
DCM&B Tools and Technology Seminar (April 8, 2021 12:00pm) https://events.umich.edu/event/79923 79923-20515556@events.umich.edu Event Begins: Thursday, April 8, 2021 12:00pm
Location: Off Campus Location
Organized By: DCMB Tools and Technology Seminar

URL for remote viewing: https://umich-health.zoom.us/j/94886745590?pwd=LzhLU243K2ZhbXNzU1BJRHQ5V25BZz09

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Livestream / Virtual Fri, 11 Dec 2020 08:19:03 -0500 2021-04-08T12:00:00-04:00 2021-04-08T13:00:00-04:00 Off Campus Location DCMB Tools and Technology Seminar Livestream / Virtual
BME 500 Seminar: James Collins (April 8, 2021 4:00pm) https://events.umich.edu/event/81393 81393-20889823@events.umich.edu Event Begins: Thursday, April 8, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

James Collins, Ph.D.
Massachusetts Institute of Technology

https://openbme.org/

ZOOM LINK TO REGISTER: https://cwru.zoom.us/webinar/register/WN_MSUiecgNTLyXR5bM8HSnR

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Lecture / Discussion Fri, 02 Apr 2021 15:01:39 -0400 2021-04-08T16:00:00-04:00 2021-04-08T17:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Alum Connections: Dr. Gina Fundaro (April 9, 2021 12:30pm) https://events.umich.edu/event/83335 83335-21344238@events.umich.edu Event Begins: Friday, April 9, 2021 12:30pm
Location: Off Campus Location
Organized By: LSA Opportunity Hub

Alum Connection: Women’s Health leader & Entrepreneur, Dr. Gina Fundaro

In January 2020, Dr. Gina Fundaro found herself at a crossroads. She was a successful breast imaging radiologist with Henry Ford Health System, while her children were also succeeding athletically in their early teenage years. After a twenty-year career impacting patients’ lives, Gina made the decision to stop practicing medicine and open three Goldfish Swim Schools in Virginia. Just over a year later, Gina is back working with patients part-time. A proud U-M Dearborn graduate, Gina attributes her liberal arts education for giving her both a desire to serve others through her medical vocation and the agility to pivot into entrepreneurial pursuits. Join Gina for a conversation about exploring a medical career in service to others--and having the courage to make life changes as an established adult and professional.

About Dr. Gina Fundaro:
A lifelong native of Michigan, Dr. Gina Fundaro spent the majority of her career at Henry Ford Health System. She was also the site director of the Henry Ford Fairlane Breast Center. Prior to this, she worked at the Alexander Walt Comprehensive Breast Center of the Karmanos Cancer Institute from 2005 to 2007. She specializes in breast imaging and breast interventional procedures. She joined a private group, Regional Medical Imaging in January 2021.

Her passion for women’s healthcare arose while in college following her grandmother’s death from preventable breast cancer. It highlighted the need to catch breast tumors early, spurring her to enter radiology and help women fight the disease.

Being a physician, it was important to Gina that her kids learned how to swim. This passion also drove Gina to learn how to swim at age 39, and in 2012, she completed an Ironman Triathlon. Two years later, Gina and her husband opened their first of three Goldfish Swim Schools in Northern, VA.

You should attend this session if you are:
A UM Literature, Science, and the Arts undergraduate student with interests in working in the field of healthcare
Interested in medical school and/or pursuing a career in medicine, specifically radiology
Hoping to learn from an alum about navigating life in medical school, as well as finding work-life balance as a practicing physician

What you’ll gain from attending this session:
Get insights from an experienced physician who currently sits on the Mott Hospital Council and Women's Health Leadership Council at Michigan Medicine
Learn about the career possibilities within medicine prior to applying to medical school.
Gain critical advice about pursuing both a lifelong career but also shorter professional pursuits

RSVP now to be part of the conversation. The link to join this Alum Connection will be emailed to you after you RSVP.

Posting Disclaimer:
RSVP now to reserve your spot. By signing up, you will receive an email with details on how to join this virtual workshop the morning of the session.

The LSA Opportunity Hub aims to deliver inclusive and accessible experiences and welcomes all LSA students to participate. If you require accommodations to participate in this event please contact the Hub at lsa-opphub@umich.edu so we can make arrangements. If you have any concerns or questions, please reach out to us at lsa-opphub@umich.edu.

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Livestream / Virtual Fri, 26 Mar 2021 10:25:45 -0400 2021-04-09T12:30:00-04:00 2021-04-09T13:30:00-04:00 Off Campus Location LSA Opportunity Hub Livestream / Virtual Dr. Gina Fundaro Photo
RC Intros: Interested in learning more about the Residential College? (April 12, 2021 5:00pm) https://events.umich.edu/event/81794 81794-20959285@events.umich.edu Event Begins: Monday, April 12, 2021 5:00pm
Location: Off Campus Location
Organized By: Residential College

RC Intros: Interested in learning more about the Residential College?

Wondering what happens after the RC? Meet RC alumni and learn about their post-grad experiences!

Monday, April 12, 5-6pm
Register at myumi.ch/E3WA5

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Reception / Open House Fri, 05 Feb 2021 14:43:56 -0500 2021-04-12T17:00:00-04:00 2021-04-12T18:00:00-04:00 Off Campus Location Residential College Reception / Open House RC Intros flier
Can Education Innovation at Michigan Medicine Benefit from Being More Cohesive? (April 14, 2021 12:00pm) https://events.umich.edu/event/83220 83220-21314487@events.umich.edu Event Begins: Wednesday, April 14, 2021 12:00pm
Location: Off Campus Location
Organized By: RISE (Research. Innovation. Scholarship. Education.)

RISE invites you attend the Virtual Talking Circle (VTC) to contribute your input in co-creating a cohesive pathway for education innovation across health science education at Michigan Medicine.  We invite you to attend and provide your input into this conversation.

Please invite your colleagues who may also be interested. See you then!

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Workshop / Seminar Wed, 24 Mar 2021 14:31:47 -0400 2021-04-14T12:00:00-04:00 2021-04-14T13:00:00-04:00 Off Campus Location RISE (Research. Innovation. Scholarship. Education.) Workshop / Seminar RISE Virtual Talking Circle
CCMB / DCMB Weekly Seminar (April 14, 2021 4:00pm) https://events.umich.edu/event/83595 83595-21436485@events.umich.edu Event Begins: Wednesday, April 14, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:
My lab's research involves the development and application of systems biology approaches—combining computation, machine learning, quantitative modeling, and experiments—to study the immune system in health and disease. Recent technological and computational advances allow comprehensive interrogation of multiple modalities (e.g., proteins, mRNAs, immune receptor sequences) in single cell resolution in the human population. Here I will highlight our work in the analysis human and single cell variations along the axes of early immune development, vaccination, and COVID-19. If time permits, I will also discuss the integration of tissue imaging, machine learning, and multiscale dynamical modeling of immune cell interactions to investigate the homeostatic regulation of autoreactive T cells.

* * *

Biography: Dr. Tsang is a senior investigator in the NIH Intramural Research Program and leads a laboratory focusing on systems and quantitative immunology at the National Institute of Allergy and Infectious Diseases (NIAID). He also co-directs the Trans-NIH Center for Human Immunology (CHI) and leads its research program in systems human immunology. Dr. Tsang trained in computer engineering and computer science at the University of Waterloo and received his Ph.D. in biophysics from Harvard University. Dr. Tsang has worked as a software engineer and pursued systems biology research in both academia and industry including Rosetta Inpharmatics, Caprion Proteomics, MIT, and Merck Research Laboratories. Dr. Tsang has won several awards for his research, including NIAID Merit Awards for the development of a data reuse and crowdsourcing platform OMiCC and for leading a system biology study of human immune variability and influenza vaccination, which was selected as a top NIAID Research Advances of 2014. He currently serves as the founding chief editor of systems immunology for Frontiers in Immunology. He has served as a scientific advisor for a number of programs and organizations including ImmPort (the clinical and molecular data repository for NIAID), the Committee on Precision Medicine for the World Allergy Organization, the NIAID Modeling Immunity for Biodefense Program, the Allen Institute, the Immuno-Epidemiology Program at the National Cancer Institute, and the Human Vaccines Project.

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Wed, 07 Apr 2021 08:59:05 -0400 2021-04-14T16:00:00-04:00 2021-04-14T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual
BME 500 Seminar: Kelly J. Cross (April 15, 2021 4:00pm) https://events.umich.edu/event/81394 81394-20889824@events.umich.edu Event Begins: Thursday, April 15, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Join us for a virtual seminar series on topics related to race and science, technology, engineering and math (STEM) education. https://happenings.wustl.edu/event/an_honest_conversation_about_inequity_in_engineering#.YG9vT-hKhPY

Details:
DATE: Thursday, April 15, 2021
TIME: 4:00-5:00 PM
ZOOM LINK TO REGISTER: https://wustl.zoom.us/webinar/register/WN_NvH4qVTSRx2uSXbdW-eXNA

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Lecture / Discussion Wed, 14 Apr 2021 14:13:34 -0400 2021-04-15T16:00:00-04:00 2021-04-15T17:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
The University of Michigan Medical School Program on Health, Spirituality and Religion presents "An Evening with Health, Spirituality and Religion: A Multi-disciplinary Conversation on a Challenging End-of-Life Clinical Scenario (April 15, 2021 7:00pm) https://events.umich.edu/event/83261 83261-21328371@events.umich.edu Event Begins: Thursday, April 15, 2021 7:00pm
Location: Off Campus Location
Organized By: The University of Michigan Medical School Program on Health, Spirituality and Religion

Join us for a discussion with a panel of experts from a variety of disciplines as we unpack a recent challenging case at our own institution. Our panel will navigate the complexity of caring for an elderly patient presenting after suicide attempt who requested DNAR status.

Kunal Bailoor, MD, House Officer, Internal Medicine, Ethics

Lori-Jean Brazier, M.Div., CPE, Spiritual Care

Sara Didoszak, BSN, RN, Clinical Nursing Supervisor, CCMU

Thomas Valley, MD, MSc, Assistant Professor of Internal Medicine, Division of Pulmonary and Critical Care

Scott Winder, MD, Associate Professor of Psychiatry and Associate Professor of Surgery

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Workshop / Seminar Wed, 24 Mar 2021 07:13:57 -0400 2021-04-15T19:00:00-04:00 2021-04-15T20:00:00-04:00 Off Campus Location The University of Michigan Medical School Program on Health, Spirituality and Religion Workshop / Seminar Health, Spirituality & Religion Program
BME Master's Defense: Fatimah Alkaabi (April 16, 2021 12:00pm) https://events.umich.edu/event/83558 83558-21424731@events.umich.edu Event Begins: Friday, April 16, 2021 12:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

The central auditory system consists of the brain nuclei that transmit peripheral auditory nerve input to the auditory cortex for hearing perception. Damage to the auditory end organ, the cochlea, can result in hearing loss that drives the central auditory system to disarray causing disorders such as hyperacusis and tinnitus. These disorders can negatively affect patients’ quality of life. Tinnitus sufferers generally describe their tinnitus as a narrowband of sound that occurs in quiet, while hyperacusis sufferers express an exaggerated perception of sound level or intensity. These two disorders are often grouped together because tinnitus sufferers tend to report symptoms of hyperacusis and vice versa. However, hyperacusis and tinnitus do not always co-occur, suggesting that they have different neural origins. To study these conditions, researchers have induced cochlear damage in animal models, followed by behavioral and electrophysiological assessments. However, no study has adequately distinguished hyperacusis from tinnitus in individual animals. In this thesis, I detail the development of a novel hyperacusis and tinnitus assessment paradigm for individual animals using the pinna reflex combined with auditory brainstem responses (ABR). In the first chapter, I detail several enhancements to a computer system that ensures accurate sound presentation concurrently with capture of pinna reflex video data, as well as streamlines the subsequent data analysis. In the second chapter, the ABR, an evoked potential reflecting the summed electrical activity of cells in the auditory brainstem pathway, was assessed. Several studies suggest that ABR-wave characteristics might provide evidence of hyperacusis. ABRs were evoked using conventional and novel sound stimuli. They were then examined to look for possible indications of hyperacusis in noise overexposed guinea pigs. The present findings are discussed with several suggestions for future hyperacusis assessments.



Date: Friday, April 16, 2021

Time: 12:00 PM

Zoom: https://umich.zoom.us/j/91698183229

Chair: Dr. Susan Shore

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Lecture / Discussion Mon, 05 Apr 2021 23:04:39 -0400 2021-04-16T12:00:00-04:00 2021-04-16T13:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
"A Relationship Based Model of Care: Combining a great compassion and a great commission ministry for better health outcomes" (April 19, 2021 12:00pm) https://events.umich.edu/event/83262 83262-21328372@events.umich.edu Event Begins: Monday, April 19, 2021 12:00pm
Location: Off Campus Location
Organized By: The University of Michigan Medical School Program on Health, Spirituality and Religion

The Woll Family Speaker Series on Health, Spirituality and Religion presents Sherie Garrison, RN and Brad Garrison, BS, RPH, M.Div.

The launch of the Luke Project 52 Clinic of Flint will combine a Great Compassion ministry to provide free prenatal care to the uninsured or under-insured in an effort to address the high infant mortality rate there with a Great Commission ministry to provide a mobile asset to local congregations to help them connect with and begin to serve again the communities that they are in. Connecting our Moms with the community support system of a church will enhance their ability to get the care they need.

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Workshop / Seminar Wed, 24 Mar 2021 07:22:00 -0400 2021-04-19T12:00:00-04:00 2021-04-19T13:00:00-04:00 Off Campus Location The University of Michigan Medical School Program on Health, Spirituality and Religion Workshop / Seminar Health, Spirituality & Religion Program
The 20th Annual Horace W. Davenport Lecture in Medical Humanities (April 19, 2021 3:00pm) https://events.umich.edu/event/83733 83733-21483492@events.umich.edu Event Begins: Monday, April 19, 2021 3:00pm
Location: Off Campus Location
Organized By: Center for the History of Medicine

The Center for the History of Medicine and the Department of English Language and Literature are pleased to announce the 20th Annual Horace W. Davenport Lecture in the Medical Humanities.

This year's lecture will feature Professor Deborah Blum, Director of the Knight Science Journalism Program at the Massachusetts Institute of Technology. Blum is a Pulitzer Prize winning science journalist, columnist and author of six books, most recently, The Poison Squad, a 2018 New York Times Notable Book, and the subject of a 2020 PBS documentary.

Blum will deliver her lecture, "Science Journalism Under the Microscope: From COVID to Climate Change," where she will explores the sometimes mysterious (to others) ways that journalists pick stories, balance evidence, find sources, and spin their tales, using examples from some of the most important stories of the last decade to illustrate good choices and bad, mistakes and successes, to make some essential and insightful points about the profession.

Blum won the Pulitzer in 1992 for a series on primate research that became her first book, The Monkey Wars. She has since focused on key moments in the history of science with books including Love at Goon Park (2002), Ghost Hunters (2006), the New York Times bestseller, The Poisoner’s Handbook (2010). A co-editor of A Field Guide for Science Writers (2006), she is now under contract with Oxford University Press as a co-editor of a forthcoming guide to science journalism. She has worked as a science columnist for The New York Times, a blogger for Wired, and has written for other publications ranging from The Wall Street Journal to Mother Jones. She was the Helen Firstbrook Franklin professor of journalism at the University of Wisconsin-Madison for 15 years before being selected as the fourth director of the Knight Science Journalism Program in 2015. Shortly later, she launched the online science magazine, Undark, which now numbers a readership in the millions and has won numerous national awards, including the George K. Polk Award.

Blum is a former president of the National Association of Science Writers, was a member of the governing board of the World Federation of Science Writers, and currently serves on the board of the Council for the Advancement of Science Writing, and on advisory boards of Chemical & Engineering News, The Scientist and the MIT Museum. She is a fellow of the American Association for the Advancement of Science (AAAS) and a lifetime associate of the National Academy of Sciences (NAS) in recognition of her work in science communication.

Please join us for this engaging presentation from one of the nation’s premiere science journalists!

Monday, April 19, 2021
3:00 - 4:00 pm

Zoom link: https://umich.zoom.us/s/95201112797

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Livestream / Virtual Tue, 13 Apr 2021 09:00:10 -0400 2021-04-19T15:00:00-04:00 2021-04-19T16:00:00-04:00 Off Campus Location Center for the History of Medicine Livestream / Virtual Science Journalism Under the Microscope: From Covid to Climate Control
RNA Seminar featuring: Jailson (Jay) Brito Querido, Ph.D. MRC Laboratory of Molecular Biology, Cambridge, UK (April 19, 2021 4:00pm) https://events.umich.edu/event/81408 81408-20893767@events.umich.edu Event Begins: Monday, April 19, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_78YYOhIhTbOBy2_JSdM7Wg

ABSTRACT: A key step in translational initiation is the recruitment of the 43S pre-initiation complex (43S PIC) by the cap-binding complex (eIF4F) at the 5´ end of mRNA. Eukaryotic initiation factors eIF1, eIF1A, eIF3, eIF5, and the ternary complex (TC) of eIF2–GTP–tRNAiMet bind to the 40S ribosomal subunit to form the 43S PIC. Once assembled, the 43S PIC is recruited to the cap-binding complex eIF4F at the 5´end of mRNA to form a 48S initiation complex (48S). The 48S then scans along the mRNA to locate a start codon. To understand the mechanisms involved, we determined the structure of a reconstituted human 48S using cryo-electron microscopy. The structure reveals insights into early events of translation initiation complex assembly. It reveals how eIF4F interacts with subunits of the eIF3 structural core near the mRNA exit channel in the 43S. The location of eIF4F is consistent with a slotting model of mRNA recruitment and suggests a “blind-region” that would preclude recognition of start sites upstream of the location of the P site at the point of recruitment.

KEYWORDS: mRNA, ribosome, eIF4F, eIF4A, translation

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Lecture / Discussion Tue, 13 Apr 2021 12:58:40 -0400 2021-04-19T16:00:00-04:00 2021-04-19T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Jailson (Jay) Brito Querido, Ph.D.
Links Between Culture and Sanitation (April 20, 2021 2:00pm) https://events.umich.edu/event/83816 83816-21540180@events.umich.edu Event Begins: Tuesday, April 20, 2021 2:00pm
Location:
Organized By: Project RISHI

Dr. Balmurli Natrajan, Professor of Anthropology at William Paterson University will speak on the social practices in communities where open defecation is prevalent, toilet use, and sanitation practices in India. The discussion will center around the link between culture and accepting modern adaptations in rural communities. RSVP Here: https://docs.google.com/forms/d/e/1FAIpQLSdaJwRFl1WH56j3j604SnuPiLF5vRvgiAHais0Hse4ISjAATA/viewform

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Conference / Symposium Tue, 20 Apr 2021 14:07:20 -0400 2021-04-20T14:00:00-04:00 2021-04-20T15:00:00-04:00 Project RISHI Conference / Symposium Dr. Balmurli Natrajan, Professor of Anthropology at William Paterson University
Bioethics Discussion: Abdication (April 20, 2021 7:00pm) https://events.umich.edu/event/58841 58841-14563735@events.umich.edu Event Begins: Tuesday, April 20, 2021 7:00pm
Location: Lurie Biomedical Engineering
Organized By: The Bioethics Discussion Group

A discussion on our renunciation.

Join us at: https://umich.zoom.us/j/99926126455

A few readings to consider:
––The Idea of Legitimate Authority in the Practice of Medicine
––Decentralization of health care systems and health outcomes: Evidence from a natural experiment
––Vox Populi or Abdication of Responsibility?: The Influence of the Irish Citizens’ Assembly on the Public Discourse Regarding Abortion, 2016-2019
––Lifeboat Ethics: The Case Against Helping the Poor
For more information and/or to receive a copy of the readings visit http://belmont.bme.umich.edu/bioethics-discussion-group/discussions/060-abdication/.

––
Before you give up, consider the blog: https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Fri, 08 Jan 2021 09:38:57 -0500 2021-04-20T19:00:00-04:00 2021-04-20T20:30:00-04:00 Lurie Biomedical Engineering The Bioethics Discussion Group Lecture / Discussion Abdication
Special Joint Seminar between DCMB, Mathematics, MIDAS, and Smale Institute (April 22, 2021 1:00pm) https://events.umich.edu/event/83615 83615-21491327@events.umich.edu Event Begins: Thursday, April 22, 2021 1:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

The quest to understand consciousness, once the purview of philosophers and theologians, is now actively pursued by scientists of many stripes. This talk looks at consciousness from the perspective of theoretical computer science. It formalizes the Global Workspace Theory (GWT) originated by cognitive neuroscientist Bernard Baars and further developed by him, Stanislas Dehaene, and others. Our major contribution lies in the precise formal definition of a Conscious Turing Machine (CTM), also called a Conscious AI. We define the CTM in the spirit of Alan Turing’s simple yet powerful definition of a computer, the Turing Machine (TM). We are not looking for a complex model of the brain nor of cognition but for a simple model of (the admittedly complex concept of) consciousness. After formally defining CTM, we give a formal definition of consciousness in CTM. We then suggest why the CTM has the feeling of consciousness. The reasonableness of the definitions and explanations can be judged by how well they agree with commonly accepted intuitive concepts of human consciousness, the range of related concepts that the model explains easily and naturally, and the extent of its agreement with scientific evidence.

https://umich.zoom.us/j/95135773568

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Livestream / Virtual Wed, 14 Apr 2021 10:17:45 -0400 2021-04-22T13:00:00-04:00 2021-04-22T14:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual
Re-orienting Ancient Medicine Courses (April 22, 2021 4:00pm) https://events.umich.edu/event/83375 83375-21367803@events.umich.edu Event Begins: Thursday, April 22, 2021 4:00pm
Location: Off Campus Location
Organized By: Department of Middle East Studies

This pedagogy workshop is aimed at (past, current, and would-be) instructors of ancient medicine, science, and technology courses who would be keen to integrate material from the pre-modern Middle East. Popular and more academic narratives often equate ancient medicine with Greco-Roman medicine and frame its study as an originist history of a monolithic western medical tradition. When these narratives introduce content from the pre-modern Middle East, such as from Assyria or the medieval Islamicate world, they define the contribution of Middle Eastern knowledge-makers in terms of their anticipation or preservation of a western science.

This workshop will discuss ways of foregrounding the theories and actors of pre-modern Middle Eastern science, technology, and medicine without rendering them subservient to a hegemonic "western tradition". Moreover, we will review a range of primary and secondary source materials that we utilize in our own teaching of these subjects. Questions or concerns can be addressed to cwebster@ucdavis.edu. Co-sponsored by the Society for Ancient Medicine and the UC Davis Early Science Workshop.

Please register here:
https://umich.zoom.us/webinar/register/WN_M-fHevFTRIuOA7fS2Z4epQ

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Livestream / Virtual Mon, 29 Mar 2021 11:10:22 -0400 2021-04-22T16:00:00-04:00 2021-04-22T17:00:00-04:00 Off Campus Location Department of Middle East Studies Livestream / Virtual poster
Links Between Culture and Sanitation (April 22, 2021 5:00pm) https://events.umich.edu/event/83816 83816-21540179@events.umich.edu Event Begins: Thursday, April 22, 2021 5:00pm
Location: Off Campus Location
Organized By: Project RISHI

Dr. Balmurli Natrajan, Professor of Anthropology at William Paterson University will speak on the social practices in communities where open defecation is prevalent, toilet use, and sanitation practices in India. The discussion will center around the link between culture and accepting modern adaptations in rural communities. RSVP Here: https://docs.google.com/forms/d/e/1FAIpQLSdaJwRFl1WH56j3j604SnuPiLF5vRvgiAHais0Hse4ISjAATA/viewform

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Conference / Symposium Tue, 20 Apr 2021 14:07:20 -0400 2021-04-22T17:00:00-04:00 2021-04-22T18:00:00-04:00 Off Campus Location Project RISHI Conference / Symposium Dr. Balmurli Natrajan, Professor of Anthropology at William Paterson University
The Implications of COVID-19 for the Care of Our Athletes, Panel Discussion (April 23, 2021 10:30am) https://events.umich.edu/event/83762 83762-21493284@events.umich.edu Event Begins: Friday, April 23, 2021 10:30am
Location: Off Campus Location
Organized By: U-M Office of Research

Join the Exercise & Sport Science Initiative (ESSI) and Michigan Center for Human Athletic Medicine & Performance (MCHAMP) for a seminar discussing the implications of COVID-19 for the care of our athletes. Experts will discuss caring for athletes on the sideline and virtually in clinic; monitoring athletes' mental health and well-being during the pandemic; assessing the impact of altered conditioning, training and gameplay on injury risk and performance; advancing COVID-19 benchtop to sideline research; and applying lessons learned from the challenges of the last year to advance the care for athletes of all ages and levels of performance.

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Lecture / Discussion Wed, 14 Apr 2021 14:57:16 -0400 2021-04-23T10:30:00-04:00 2021-04-23T11:30:00-04:00 Off Campus Location U-M Office of Research Lecture / Discussion Elite baseball player with COVID-19 mask
20th Annual James V. Neel Lectureship (April 23, 2021 11:00am) https://events.umich.edu/event/83872 83872-21561727@events.umich.edu Event Begins: Friday, April 23, 2021 11:00am
Location: Off Campus Location
Organized By: Department of Human Genetics

DEPARTMENT OF HUMAN GENETICS - 20TH ANNUAL JAMES V. NEEL LECTURESHIP

“Remembrance of Things Past: Reactivation of Fetal Hemoglobin for Therapy.”

Presented by:
Stuart H. Orkin, M.D.
David G. Nathan Distinguished Professor of Pediatrics
Investigator, Howard Hughes Medical Institute
Harvard Medical School

FRIDAY, MAY 7, 2021
12:00PM - 3:00PM EST
Zoom Meeting ID: 983 1136 4189
Zoom Meeting Link: https://umich.zoom.us/j/98311364189

Sponsored by:
The Department of Human Genetics
University of Michigan Medical School
Event Website: https://medicine.umich.edu/dept/human-genetics/events/202105/20th-annual-james-v-neel-lectureship

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Lecture / Discussion Fri, 23 Apr 2021 11:02:42 -0400 2021-04-23T11:00:00-04:00 2021-04-23T12:00:00-04:00 Off Campus Location Department of Human Genetics Lecture / Discussion 2021 JAMES V. NEEL LECTURESHIP FLYER
National Prescription Drug Take Back Day (April 24, 2021 10:00am) https://events.umich.edu/event/83798 83798-21532314@events.umich.edu Event Begins: Saturday, April 24, 2021 10:00am
Location: Off Campus Location
Organized By: Michigan Medicine

The United States is currently experiencing an epidemic of prescription drug misuse and abuse. Opioid overdoses in Michigan have surged during the COVID-19 pandemic. To help combat this epidemic, the Michigan Opioid Prescribing Engagement Network (Michigan OPEN) is partnering with hospitals, pharmacies, community organizations and police departments around the state to host medication take back events on Saturday, April 24 from 10 a.m. to 2 p.m.

Research has found that about 70 percent of the opioids prescribed for surgery go unused and those medications are not disposed of. This increases the potential for these medications to be diverted back into the community or contaminate waterways. However, Michigan OPEN’s efforts with take back events have led to more than 13,000 pounds of unused medications and approximately 235,000 opioids being collected and properly disposed of.

Take back events provide a safe process for disposing of unused medications while protecting our communities, children and environment. Remove the risk from your home and bring any unused opioids to a Take Back Event in your community.

Find take back event locations throughout Michigan by visiting http://michigan-open.org/.

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Other Mon, 19 Apr 2021 14:05:02 -0400 2021-04-24T10:00:00-04:00 2021-04-24T14:00:00-04:00 Off Campus Location Michigan Medicine Other Medication take back event
Questions About the COVID-19 Vaccines? A Michigan Medicine livestream (April 28, 2021 4:00pm) https://events.umich.edu/event/83885 83885-21593461@events.umich.edu Event Begins: Wednesday, April 28, 2021 4:00pm
Location: Off Campus Location
Organized By: Michigan Medicine

Are you or a loved one still undecided about the COVID-19 vaccines? Two U-M experts will answer audience questions live in this free one-hour virtual event.

The event features:
Dr. Diane Harper of the Department of Family Medicine and the Center for Disability Health & Wellness, who has studied vaccination issues and preventive care guidelines
Dr. Payal Patel of the Division of Infectious Diseases in the Department of Internal Medicine, and the VA Ann Arbor Healthcare System, who studies infection prevention and was one of the first U-M employees to be vaccinated

Post your questions in the comments on the live feed on the Michigan Medicine YouTube, Facebook or Twitter channel. Or email them to ask-michmed@med.umich.edu.

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Livestream / Virtual Tue, 27 Apr 2021 09:05:40 -0400 2021-04-28T16:00:00-04:00 2021-04-28T17:00:00-04:00 Off Campus Location Michigan Medicine Livestream / Virtual COVID vaccine vial held in gloved hands, seen on the screen of a smartphone above a laptop
WEBINAR: From Rhetoric to Reality - Putting Patients at the Heart of Pharmaceutical Services & Systems (April 29, 2021 9:00am) https://events.umich.edu/event/83639 83639-21446272@events.umich.edu Event Begins: Thursday, April 29, 2021 9:00am
Location: Off Campus Location
Organized By: Michigan Ross

Access to essential medicines remains a critical challenge for patients in many parts of the world. Strengthening pharmaceutical supply chains, while vitally important, must be complemented by efforts to strengthen related pharmaceutical services and systems in ways that put patient needs first.

When pharmaceutical systems and services – from policies and regulations to distribution and dispensing practices – are centered around and responsive to patient needs, the system can work better to achieve improved health outcomes and address critical challenges such as antimicrobial resistance. Ultimately, patient-centered approaches help build trust in health systems, encourage appropriate use of medicines, and make pharmaceutical services more responsive and effective.

Convened by the Global Health Supply Chain Summit group, this webinar will bring together private- and public-sector experts across the pharmaceutical supply chain to explore the latest in advancing patient-centered pharmaceutical services in low- and middle-income countries and opportunities to take the discussion from rhetoric to reality.

Introduction by: Ravi Anupindi, Professor of Technology & Operations, Ross School of Business
Moderated by: Lloyd Matowe, Chair, People that Deliver; Director, Pharmaceutical Systems Africa
PROGRAM SPEAKERS
• Suneeta Sharma, Vice President, Health Practice and Director, Health Policy Plus Project, Palladium
• Neimatu D. Adjabui, Senior Program Lead, West Africa, United States Pharmacopeia (USP)
• Mirfin Mpundu, Director, React Africa
• Alex Dodoo, Director, African Collaborating Centre for Pharmacovigilance
• Marlon Banda, Chair of the Board, Ecumenical Pharmaceutical Network

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Conference / Symposium Thu, 08 Apr 2021 16:15:04 -0400 2021-04-29T09:00:00-04:00 2021-04-29T10:30:00-04:00 Off Campus Location Michigan Ross Conference / Symposium Free Webinar: April 29th, 2021
Master's Defense: Ivo Cerda (April 30, 2021 10:00am) https://events.umich.edu/event/83915 83915-21612995@events.umich.edu Event Begins: Friday, April 30, 2021 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

Co-registering, chronic, and naturalistic assessments of the electrophysiological and behavioral features of the murine stress response can teach us how stress-behaviors are mechanistically driven by electrophysiological activity in neural circuits, how those relationships change over the course of the multi-week developing response to chronic ongoing stress, and how these changes ultimately contribute to the pathogenesis and progression of major depressive disorder and other psychiatric conditions. However, the long duration and multiplexed nature of the murine stress response have long been barriers to achieving such understandings. To address the need for technology that better captures the time progression of the murine stress response, we engineered the first-ever chronic recording system capable of gathering both behavioral and electrophysiological data in a naturalistic environment for freely-moving mice. Building from previous unpublished work at our lab, we first developed 16 units of a novel photointerrupter-based, Arduino-controlled digital phenotyping system capable of simultaneously recording 50+ behavioral metrics at a sub-second resolution continuously for weeks at a time. Subsequently, with the goal of assisting the concurrent exploration of brain mechanisms and behavior, we engineered a scaffold and cabling structure to support an ultra low-resistance commutator that allows chronic, multi-region brain electrophysiological recordings and integrated it into our digital behavioral phenotyping system. Our novel co-recording system is now fully operational and, along with allowing chronic electrophysiological recordings, supports measures of eating, drinking, food and sugary drink preference (a measure of anhedonia), locomotor activity, sleep, and actigraphy, all the while using 24/7 video tracking to allow detailed classification of behaviors at sub-second resolution. The system is also compatible with standard assessments in the field, including daily weight and fur checks. To demonstrate the duration of its co-recording capabilities, we implanted a cohort of mice with electrodes in three brain regions involved in the murine stress response – olfactory bulb, dorsal hippocampus, and medial prefrontal cortex – and recorded for five weeks. This is the first system to ever produce highly dense behavioral and electrophysiological data simultaneously and continuously over such a period of time.


Details:
DATE: Friday, April 30, 2021
TIME: 10:00 am - 12:00 pm
LOCATION: Zoom https://umich.zoom.us/j/93571968494)
Chair Committee: Brendon Watson, Tim Bruns, Cindy Chestek

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Lecture / Discussion Thu, 29 Apr 2021 20:12:17 -0400 2021-04-30T10:00:00-04:00 2021-04-30T12:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
BME Commencement 2021 (May 1, 2021 3:30pm) https://events.umich.edu/event/83890 83890-21595415@events.umich.edu Event Begins: Saturday, May 1, 2021 3:30pm
Location: Off Campus Location
Organized By: Biomedical Engineering

PLEASE MAKE SURE TO RSVP WITH THE LINK!

BME COMMENCEMENT CEREMONY
SATURDAY, MAY 1, 2021 | 3:30 PM EDT


COMMENCEMENT CEREMONY
ZOOM @ (3:30 PM)

AFTER PARTY
Spatial Chat @ (~4:30 PM)
(AFTER THE CEREMONY)

PROGRAM
Welcome & Introduction | Lonnie Shea Ph.D.
Program Chair Remarks | Rachael Schmedlen, Ph.D., Jan Stegemann, Ph.D., & Tim Bruns, Ph.D.
Program Coordinator Remarks | Rachel Patterson & Maria Steele
Alumni Welcome and Congratulations | Scott Merz, Richard Youngblood, & Xiaotian Tan
Student Addresses | Dipra Debnath, Ivo Woldarsky, & Katy Norman
Announcing the Graduates | Melissa Wrobel Ph.D., Brendon Baker, Ph.D., James Weiland, Ph.D., & Tim Bruns, Ph.D.
Confirmation of Degrees | Lonnie Shea, Ph.D.
Congratulations and Closing | Lonnie Shea, Ph.D.
Virtual socializing & After Party | Come congratulate and socialize with your fellow graduates, families, professors, and friends following the BME Commencement Ceremony.

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Ceremony / Service Tue, 27 Apr 2021 15:09:45 -0400 2021-05-01T15:30:00-04:00 Off Campus Location Biomedical Engineering Ceremony / Service BME Logo
RNA Seminar featuring: Olivia Rissland, University of Colorado School of Medicine (May 3, 2021 4:00pm) https://events.umich.edu/event/81302 81302-20881902@events.umich.edu Event Begins: Monday, May 3, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

Registration Required: https://umich.zoom.us/webinar/register/WN_vA9zYS5nSEenf8Zmt1f-qA


ABSTRACT: The maternal-to-zygotic transition (MZT) is a conserved step in animal development, where control is passed from the maternal to the zygotic genome. Although the MZT is typically considered from its impact on the transcriptome, we previously found that three maternally deposited Drosophila RNA binding proteins (ME31B, Trailer Hitch [TRAL], and Cup) are also cleared during the MZT by unknown mechanisms. Here, we show that these proteins are degraded by the ubiquitin-proteasome system. Marie Kondo, an E2 conjugating enzyme, and the E3 CTLH ligase are required for the destruction of ME31B, TRAL, and Cup. Structure modeling of the Drosophila CTLH complex suggests that substrate recognition is different than orthologous complexes. Despite occurring hours earlier, egg activation mediates clearance of these proteins through the Pan Gu kinase, which stimulates translation of Kondo mRNA. Clearance of the maternal protein dowry thus appears to be a coordinated, but as-yet underappreciated, aspect of the MZT.

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Lecture / Discussion Fri, 02 Apr 2021 16:07:11 -0400 2021-05-03T16:00:00-04:00 2021-05-03T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Olivia Rissland, Ph.D.
Get Vaccinated Against COVID-19 at Michigan Stadium (May 4, 2021 10:00am) https://events.umich.edu/event/83955 83955-21619193@events.umich.edu Event Begins: Tuesday, May 4, 2021 10:00am
Location: Michigan Stadium
Organized By: Michigan Medicine

Michigan Medicine is making COVID-19 vaccination available to anyone over the age of 16 on a walk-in basis at Michigan Stadium, in the Jack Roth Stadium Club overlooking the field.

First and second doses of Pfizer vaccine are available, and no appointment or history of receiving treatment at Michigan Medicine is needed.

For full details, including information on how to set up a Medical Record Number for those who have not been to a Michigan Medicine clinic or hospital before, and important information for those seeking second doses, visit
https://www.uofmhealth.org/coronavirus/vaccine-info-update

Directions on where to park and how to enter the stadium and reach the club level where vaccinations are being given: https://www.uofmhealth.org/coronavirus/vaccination-appointment

People who are under 18 need parental consent in person or over the phone.

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Well-being Mon, 03 May 2021 10:02:35 -0400 2021-05-04T10:00:00-04:00 2021-05-04T16:00:00-04:00 Michigan Stadium Michigan Medicine Well-being Get your vaccine at the Michigan Stadium
PhD Defense: Jonas Schollenberger (May 4, 2021 3:00pm) https://events.umich.edu/event/83855 83855-21555868@events.umich.edu Event Begins: Tuesday, May 4, 2021 3:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Cerebrovascular occlusive disease (CVOD) is a major risk factor for ischemic stroke and is characterized by the presence of stenosis in the arteries supplying the brain. The cerebral vasculature has an innate ability to compensate for flow reductions, caused by the presence of CVOD, through a network of collateral pathways in the circle of Willis (CoW). However, flow compensation is highly patient-specific and dependent on the cerebral vasculature anatomy, availability of collateral pathways, degree of stenosis and, the condition of the cerebral microcirculation and its autoregulatory response. Unfortunately, clinically available imaging tools only provide limited information on flow compensation and the underlying cerebral hemodynamics. Given the complexity of the cerebral vasculature, better tools are necessary to characterize cerebral hemodynamics and guide the risk assessment of ischemic stroke.



Image-based computational fluid dynamics (CFD) provides a powerful tool for non-invasively analyzing cerebral hemodynamics with high spatial and temporal resolutions. However, CFD modeling of cerebral hemodynamics is challenging due to the need for patient-specific data to calibrate outflow boundary conditions in the brain. In this thesis, we explore a novel strategy to quantitatively characterize cerebral hemodynamics using CFD in combination with tissue perfusion from arterial spin labeling (ASL) MRI.



Firstly, we quantified territorial perfusion in the cerebral circulation through implementing and optimizing a vessel-selective arterial spin labeling (VS-ASL) sequence. VS-ASL is generally limited by its low labeling efficiency causing poor signal-to-noise ratio. We investigated the effects of off‐resonance, pulsatility, and vessel movement, and evaluated methods to maximize labeling efficiency and overall image quality. We found that an off-resonance calibration scan in combination with cardiac-triggering significantly improved labeling efficiency and image quality. Vessel movement during the MRI protocol occurred in the majority of study subjects and needs to be accounted for to maximize labeling efficiency.



Secondly, we developed a strategy to calibrate patient-specific CFD models of cerebral blood flow. The calibration consisted of estimating the total inflow to the CoW from PC-MRI and the flow splits in the CoW from non-selective ASL perfusion images. The outflow boundary conditions were iteratively tuned to match the estimated flow splits, and the ASL-calibrated CFD model was then validated against territorial perfusion maps from VS-ASL by calculating the blood supply to each cerebral territory using Lagrangian particle tracking (LPT). We found an overall good match in a small group of subjects; particularly, the flow compensation between hemispheres was captured well by the calibrated CFD models.



Thirdly, we investigated the impact of two outflow boundary condition strategies, an ASL-based and allometric-based calibration, on cerebral hemodynamics. The ASL-based calibrated CFD analysis captured the flow compensation between hemispheres as measured with VS-ASL and lead to an approximately symmetrical flow distribution in the CoW. In contrast, the allometric-based calibrated CFD analysis was unable to capture the collateral flow compensation, which resulted in large differences in flow between hemispheres.



Finally, the clinical feasibility and capabilities of our proposed CFD analysis was demonstrated in two CVOD patients. The CFD analysis showed significant differences in cerebral hemodynamics between the patients despite similar degrees of stenosis severity, highlighting the importance of a patient-specific assessment. Comparison of pre-operative and post-operative hemodynamics in one patient resulted in only minor changes following revascularization despite severe carotid stenosis. We demonstrated that our CFD analysis can provide detailed and quantitative information about hemodynamic impact of carotid stenosis and collateral flow compensation in the circle of Willis.


Date: Tuesday, May 4, 2021

Time: 3:00 PM

Zoom: https://umich.zoom.us/j/93059726229 (Zoom link requires prior registration)

Co-Chairs: Dr. C. Alberto Figueroa and Dr. Luis Hernandez-Garcia

For Assistance or Questions
um-bme@umich.edu

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Lecture / Discussion Thu, 22 Apr 2021 13:33:46 -0400 2021-05-04T15:00:00-04:00 2021-05-04T16:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Get Vaccinated Against COVID-19 at Michigan Stadium (May 5, 2021 10:00am) https://events.umich.edu/event/83955 83955-21619194@events.umich.edu Event Begins: Wednesday, May 5, 2021 10:00am
Location: Michigan Stadium
Organized By: Michigan Medicine

Michigan Medicine is making COVID-19 vaccination available to anyone over the age of 16 on a walk-in basis at Michigan Stadium, in the Jack Roth Stadium Club overlooking the field.

First and second doses of Pfizer vaccine are available, and no appointment or history of receiving treatment at Michigan Medicine is needed.

For full details, including information on how to set up a Medical Record Number for those who have not been to a Michigan Medicine clinic or hospital before, and important information for those seeking second doses, visit
https://www.uofmhealth.org/coronavirus/vaccine-info-update

Directions on where to park and how to enter the stadium and reach the club level where vaccinations are being given: https://www.uofmhealth.org/coronavirus/vaccination-appointment

People who are under 18 need parental consent in person or over the phone.

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Well-being Mon, 03 May 2021 10:02:35 -0400 2021-05-05T10:00:00-04:00 2021-05-05T16:00:00-04:00 Michigan Stadium Michigan Medicine Well-being Get your vaccine at the Michigan Stadium
Get Vaccinated Against COVID-19 at Michigan Stadium (May 6, 2021 10:00am) https://events.umich.edu/event/83955 83955-21619195@events.umich.edu Event Begins: Thursday, May 6, 2021 10:00am
Location: Michigan Stadium
Organized By: Michigan Medicine

Michigan Medicine is making COVID-19 vaccination available to anyone over the age of 16 on a walk-in basis at Michigan Stadium, in the Jack Roth Stadium Club overlooking the field.

First and second doses of Pfizer vaccine are available, and no appointment or history of receiving treatment at Michigan Medicine is needed.

For full details, including information on how to set up a Medical Record Number for those who have not been to a Michigan Medicine clinic or hospital before, and important information for those seeking second doses, visit
https://www.uofmhealth.org/coronavirus/vaccine-info-update

Directions on where to park and how to enter the stadium and reach the club level where vaccinations are being given: https://www.uofmhealth.org/coronavirus/vaccination-appointment

People who are under 18 need parental consent in person or over the phone.

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Well-being Mon, 03 May 2021 10:02:35 -0400 2021-05-06T10:00:00-04:00 2021-05-06T16:00:00-04:00 Michigan Stadium Michigan Medicine Well-being Get your vaccine at the Michigan Stadium
Get Vaccinated Against COVID-19 at Michigan Stadium (May 7, 2021 10:00am) https://events.umich.edu/event/83955 83955-21619196@events.umich.edu Event Begins: Friday, May 7, 2021 10:00am
Location: Michigan Stadium
Organized By: Michigan Medicine

Michigan Medicine is making COVID-19 vaccination available to anyone over the age of 16 on a walk-in basis at Michigan Stadium, in the Jack Roth Stadium Club overlooking the field.

First and second doses of Pfizer vaccine are available, and no appointment or history of receiving treatment at Michigan Medicine is needed.

For full details, including information on how to set up a Medical Record Number for those who have not been to a Michigan Medicine clinic or hospital before, and important information for those seeking second doses, visit
https://www.uofmhealth.org/coronavirus/vaccine-info-update

Directions on where to park and how to enter the stadium and reach the club level where vaccinations are being given: https://www.uofmhealth.org/coronavirus/vaccination-appointment

People who are under 18 need parental consent in person or over the phone.

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Well-being Mon, 03 May 2021 10:02:35 -0400 2021-05-07T10:00:00-04:00 2021-05-07T16:00:00-04:00 Michigan Stadium Michigan Medicine Well-being Get your vaccine at the Michigan Stadium
PhD Defense: Elissa Welle (May 7, 2021 10:00am) https://events.umich.edu/event/83883 83883-21587612@events.umich.edu Event Begins: Friday, May 7, 2021 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

Neural interfaces create a connection between neural structures in the body and external electronic devices. Brain-machine interfaces and bioelectric medicine therapies rely on the seamless integration of neural interfaces with the brain, nerves, or spinal cord. However, conventional neural interfaces cannot meet the demands of high channel count, signal fidelity, and signal longevity that these applications require.



In this thesis we characterized the damage resulting from conventional Utah arrays after multiple years of implantation in the cortex of a non-human primate. The neuron density around the electrode shanks was compared to the neuron density of nearby healthy tissue, finding a 73% loss in density around the electrodes. The explanted arrays were imaged and characterized for forms of electrode surface inconsistency. Coating cracks, tip breakage, and parylene cracks were the most common inconsistency. A significantly higher number of tip breakage and coating crack occurrences were found on the edges of the arrays as compared to the middle. In this work, we made clear the need for a minimally damaging alternative to the Utah electrode array.



Neural interfaces composed of carbon fiber electrodes, with a diameter of 6.8 microns, could enable a more seamless integration with the body. Previous work resulted in an array of individuated carbon fiber electrodes that could record reliably high signal-to-noise ratio neural signals from the brain for several months. However, the carbon fiber arrays were limited by only 30% of the electrodes recording neural signals, despite inducing very minimal inflammation. Additionally, it was relatively unknown if carbon fibers would make suitable long-term peripheral neural interfaces. Here, we illustrate the potential of carbon fiber electrodes to meet the needs of a variety of neural applications.



First, we optimized state-of-the-art carbon fiber electrodes to reliably record single unit electrophysiology from the brain. By analyzing the previous manufacturing process, the cause of the low recording yield of the carbon fiber arrays was identified as the consistency of the electrode tip. A novel laser cutting technique was developed to produce a consistent carbon fiber tip geometry, resulting in a near tripling of recording yield of high amplitude chronic neural signals. The longevity of the carbon fiber arrays was also addressed. The conventional polymer coating was compared against platinum iridium coating and an oxygen plasma treatment, both of which outperformed the polymer coating. In this work, we customized carbon fiber electrodes for reliable, long-term neural recording.



Secondly, we translated the carbon fiber technology from the brain to the periphery in an architecture appropriate for chronic implantation. The insertion of carbon fibers into the stiffer structures in the periphery is enabled by sharpening the carbon fibers. The sharpening process combines a butane flame to sharpen the fibers with a water bath to protect the base of the array. Sharpened carbon fibers recorded electrophysiology from the rat vagus nerve and feline dorsal root ganglia, both structures being important targets for bioelectric medicine therapies. The durability of carbon fibers was also displayed when partially embedded carbon fibers in medical-grade silicone withstood thousands of repeated bends without fracture. This work showed that carbon fibers have the electrical and structural properties necessary for chronic application.



Overall, this work highlights the vast potential of carbon fiber electrodes. Through this thesis, future brain-machine interfaces and bioelectric medicine therapies may utilize sub-cellular electrodes such as carbon fibers in medical applications.



Date: Friday, May 7, 2021

Time: 10:00 AM

Zoom: https://umich.zoom.us/j/95839545566 (Zoom link requires prior registration)

Chair: Dr. Cynthia Chestek

For Assistance or Questions
um-bme@umich.edu

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Lecture / Discussion Mon, 26 Apr 2021 17:03:39 -0400 2021-05-07T10:00:00-04:00 2021-05-07T11:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Get Vaccinated Against COVID-19 at Michigan Stadium (May 8, 2021 10:00am) https://events.umich.edu/event/83955 83955-21619197@events.umich.edu Event Begins: Saturday, May 8, 2021 10:00am
Location: Michigan Stadium
Organized By: Michigan Medicine

Michigan Medicine is making COVID-19 vaccination available to anyone over the age of 16 on a walk-in basis at Michigan Stadium, in the Jack Roth Stadium Club overlooking the field.

First and second doses of Pfizer vaccine are available, and no appointment or history of receiving treatment at Michigan Medicine is needed.

For full details, including information on how to set up a Medical Record Number for those who have not been to a Michigan Medicine clinic or hospital before, and important information for those seeking second doses, visit
https://www.uofmhealth.org/coronavirus/vaccine-info-update

Directions on where to park and how to enter the stadium and reach the club level where vaccinations are being given: https://www.uofmhealth.org/coronavirus/vaccination-appointment

People who are under 18 need parental consent in person or over the phone.

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Well-being Mon, 03 May 2021 10:02:35 -0400 2021-05-08T10:00:00-04:00 2021-05-08T16:00:00-04:00 Michigan Stadium Michigan Medicine Well-being Get your vaccine at the Michigan Stadium
Get Vaccinated Against COVID-19 at Michigan Stadium (May 9, 2021 10:00am) https://events.umich.edu/event/83955 83955-21619198@events.umich.edu Event Begins: Sunday, May 9, 2021 10:00am
Location: Michigan Stadium
Organized By: Michigan Medicine

Michigan Medicine is making COVID-19 vaccination available to anyone over the age of 16 on a walk-in basis at Michigan Stadium, in the Jack Roth Stadium Club overlooking the field.

First and second doses of Pfizer vaccine are available, and no appointment or history of receiving treatment at Michigan Medicine is needed.

For full details, including information on how to set up a Medical Record Number for those who have not been to a Michigan Medicine clinic or hospital before, and important information for those seeking second doses, visit
https://www.uofmhealth.org/coronavirus/vaccine-info-update

Directions on where to park and how to enter the stadium and reach the club level where vaccinations are being given: https://www.uofmhealth.org/coronavirus/vaccination-appointment

People who are under 18 need parental consent in person or over the phone.

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Well-being Mon, 03 May 2021 10:02:35 -0400 2021-05-09T10:00:00-04:00 2021-05-09T16:00:00-04:00 Michigan Stadium Michigan Medicine Well-being Get your vaccine at the Michigan Stadium
2021 BME Symposium (May 10, 2021 12:00pm) https://events.umich.edu/event/82858 82858-21203302@events.umich.edu Event Begins: Monday, May 10, 2021 12:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

To register please see:
https://myumi.ch/r8GzZ

The 2021 BME symposium will showcase our work in the areas of Imaging, Neural Engineering, Regenerative Medicine, and Precision Health. The event will take place over two days in the afternoons of Monday, May 10, 12:00 PM - 5:00 PM, and Tuesday, May 11, 12:00 PM - 5:00 PM. Each afternoon will include faculty talks, mini student dissertations, a panel discussion, and student poster sessions.

The goal of this event is to bring together faculty and students affiliated with BME from all parts of campus as a step toward building the BME community and celebrating accomplishments through difficult times while having an eye toward the future.

Please sign up and join us!

2021 U-M BME Symposium



May 10, 2021: 12:00 PM - 5:00 PM


Imaging at UM

May 10, 2021 - 12:00pm - 1:30pm
Location: Virtual/Zoom
Livestream Available (Visible After Registration)

Moderator: Doug Noll
12:00 - 12:15 - Zhongming Liu, “Preclinical MRI of brain-gut interactions”
12:15 - 12:30 - Nicole Seiberlich, “Translating Quantitative MRI to the Clinic”
12:30 - 12:45 - Yannis Paulus, “Multimodal Photoacoustic Microscopy, OCT, and Fluorescence Molecular and Cellular Imaging of the Retina”
12:45 - 1:05 - Student Dissertations
1:05 - 1:30 - Panel Discussion - “The Future of Imaging Research at Michigan” - Vikas Gulani, Jeff Fessler, Cheri Deng, Zhen Xu, Xueding Wang


Neural Engineering at UM

May 10, 2021 - 2:00pm - 3:30pm
Location: Virtual/Zoom
Livestream Available (Visible After Registration)

Moderator: Jim Weiland
2:00 - 2:15 - Kamran Diba, TBD
2:15 - 2:30 - Scott Lempka, TBD
2:30 - 2:45 - Deanna Gates, TBD
2:45 - 3:05 - Student Dissertations
3:05 - 3.30 - Panel Discussion - “The Science Fiction Future of Neural Engineering” - Cindy Chestek, Parag Patil, Tim Bruns, Bill Stacey


Poster Session: Imaging & Neural Engineering

May 10, 2021 - 4:00pm - 5:00pm
Location: Virtual/Spatial Chat

This poster session will give BME students a chance to present and discuss their research in the areas of Imaging and Neural Engineering.


May 11, 2021: 12:00 PM - 5:00 PM


Regenerative Medicine at UM

May 11, 2021 - 12:00pm - 1:30pm
Location: Virtual/Zoom
Livestream Available (Visible After Registration)

Moderator: Lonnie Shea
12:00 - 12:15 - Carlos Aguilar, ”Understanding & Re-Writing Stem Cell Programs to Live Forever.”
12:15 - 12:30 - Idse Heemskerk, “Predicting cell fate from signaling history in human pluripotent stem cells”
12:30 - 12:45 - Ariella Shikanov, TBD
12:45 - 1:05 - Student Dissertations
1:05 - 1:30 - Panel Discussion - "Grand Challenges in Regenerative Medicine" - Dave Kohn


Precision Health at UM

May 11, 2021 - 2:00pm - 3:30pm
Location: Virtual/Zoom
Livestream Available (Visible After Registration)

Moderator: TBD
2:00 - 2:15 - Sriram Chandrasekharan, TBD
2:15 - 2: 30 - James Moon, TBD
2:30 - 2:45 - Deepak Nagrath, TBD
2:45 - 3:05 - Student Dissertations
3:05 - 3:30 - Panel Discussion - "Hope or Hype for Treating Diseases" - James Moon, Sriram Chandrasekharan, Deepak Nagrath



Poster Session: Regenerative Medicine & Precision Health


May 11, 2021 - 4:00pm - 5:00pm
Location: Virtual/Spatial Chat


This poster session will give BME students a chance to present and discuss their research in the areas of Regenerative Medicine and Precision Health.

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Conference / Symposium Thu, 22 Apr 2021 13:38:37 -0400 2021-05-10T12:00:00-04:00 2021-05-10T17:00:00-04:00 Off Campus Location Biomedical Engineering Conference / Symposium BME Logo
From Medical Image to Icon: How Art Can Heal a Broken Body (May 10, 2021 12:00pm) https://events.umich.edu/event/83790 83790-21530352@events.umich.edu Event Begins: Monday, May 10, 2021 12:00pm
Location: Off Campus Location
Organized By: The University of Michigan Medical School Program on Health, Spirituality and Religion

Devan Stahl is an Assistant Professor of Bioethics in the Department of Religion at Baylor University. Her research interests include disability ethics, medicine and the visual arts, and theological bioethics. Dr. Stahl’s last book, Imaging and Imagining Illness: Becoming Whole in a Broken Body is an edited volume examining the power of medical images on the experience of chronic illness and disability.

Abstract: Many people will first learn they have an illness through a medical image such as an MRI, but these images often deny the messiness, ambiguities, and the identity of the patient who is represented in them. In this presentation, Devan Stahl explores how medical images have historically revealed the implicit theology of the culture in which they are produced. Today, a growing number of artists with disabilities are transforming their medical images into works of art, which raise deeply theological questions concerning what it means to be embodied and how our bodies relate to a transcendent God.

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Workshop / Seminar Mon, 19 Apr 2021 07:45:19 -0400 2021-05-10T12:00:00-04:00 2021-05-10T13:00:00-04:00 Off Campus Location The University of Michigan Medical School Program on Health, Spirituality and Religion Workshop / Seminar
2021 BME Symposium (May 11, 2021 12:00pm) https://events.umich.edu/event/82858 82858-21555869@events.umich.edu Event Begins: Tuesday, May 11, 2021 12:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

To register please see:
https://myumi.ch/r8GzZ

The 2021 BME symposium will showcase our work in the areas of Imaging, Neural Engineering, Regenerative Medicine, and Precision Health. The event will take place over two days in the afternoons of Monday, May 10, 12:00 PM - 5:00 PM, and Tuesday, May 11, 12:00 PM - 5:00 PM. Each afternoon will include faculty talks, mini student dissertations, a panel discussion, and student poster sessions.

The goal of this event is to bring together faculty and students affiliated with BME from all parts of campus as a step toward building the BME community and celebrating accomplishments through difficult times while having an eye toward the future.

Please sign up and join us!

2021 U-M BME Symposium



May 10, 2021: 12:00 PM - 5:00 PM


Imaging at UM

May 10, 2021 - 12:00pm - 1:30pm
Location: Virtual/Zoom
Livestream Available (Visible After Registration)

Moderator: Doug Noll
12:00 - 12:15 - Zhongming Liu, “Preclinical MRI of brain-gut interactions”
12:15 - 12:30 - Nicole Seiberlich, “Translating Quantitative MRI to the Clinic”
12:30 - 12:45 - Yannis Paulus, “Multimodal Photoacoustic Microscopy, OCT, and Fluorescence Molecular and Cellular Imaging of the Retina”
12:45 - 1:05 - Student Dissertations
1:05 - 1:30 - Panel Discussion - “The Future of Imaging Research at Michigan” - Vikas Gulani, Jeff Fessler, Cheri Deng, Zhen Xu, Xueding Wang


Neural Engineering at UM

May 10, 2021 - 2:00pm - 3:30pm
Location: Virtual/Zoom
Livestream Available (Visible After Registration)

Moderator: Jim Weiland
2:00 - 2:15 - Kamran Diba, TBD
2:15 - 2:30 - Scott Lempka, TBD
2:30 - 2:45 - Deanna Gates, TBD
2:45 - 3:05 - Student Dissertations
3:05 - 3.30 - Panel Discussion - “The Science Fiction Future of Neural Engineering” - Cindy Chestek, Parag Patil, Tim Bruns, Bill Stacey


Poster Session: Imaging & Neural Engineering

May 10, 2021 - 4:00pm - 5:00pm
Location: Virtual/Spatial Chat

This poster session will give BME students a chance to present and discuss their research in the areas of Imaging and Neural Engineering.


May 11, 2021: 12:00 PM - 5:00 PM


Regenerative Medicine at UM

May 11, 2021 - 12:00pm - 1:30pm
Location: Virtual/Zoom
Livestream Available (Visible After Registration)

Moderator: Lonnie Shea
12:00 - 12:15 - Carlos Aguilar, ”Understanding & Re-Writing Stem Cell Programs to Live Forever.”
12:15 - 12:30 - Idse Heemskerk, “Predicting cell fate from signaling history in human pluripotent stem cells”
12:30 - 12:45 - Ariella Shikanov, TBD
12:45 - 1:05 - Student Dissertations
1:05 - 1:30 - Panel Discussion - "Grand Challenges in Regenerative Medicine" - Dave Kohn


Precision Health at UM

May 11, 2021 - 2:00pm - 3:30pm
Location: Virtual/Zoom
Livestream Available (Visible After Registration)

Moderator: TBD
2:00 - 2:15 - Sriram Chandrasekharan, TBD
2:15 - 2: 30 - James Moon, TBD
2:30 - 2:45 - Deepak Nagrath, TBD
2:45 - 3:05 - Student Dissertations
3:05 - 3:30 - Panel Discussion - "Hope or Hype for Treating Diseases" - James Moon, Sriram Chandrasekharan, Deepak Nagrath



Poster Session: Regenerative Medicine & Precision Health


May 11, 2021 - 4:00pm - 5:00pm
Location: Virtual/Spatial Chat


This poster session will give BME students a chance to present and discuss their research in the areas of Regenerative Medicine and Precision Health.

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Conference / Symposium Thu, 22 Apr 2021 13:38:37 -0400 2021-05-11T12:00:00-04:00 2021-05-11T17:00:00-04:00 Off Campus Location Biomedical Engineering Conference / Symposium BME Logo
Connecting Education Innovation to Activism (May 12, 2021 12:00pm) https://events.umich.edu/event/83807 83807-21538170@events.umich.edu Event Begins: Wednesday, May 12, 2021 12:00pm
Location: Off Campus Location
Organized By: RISE (Research. Innovation. Scholarship. Education.)

R.I.S.E., the Center for Academic Innovation, and the Center for Research on Learning & Teaching (CRLT) invite you to join a Virtual Talking Circle (VTC) to discuss unique connections between education innovation & activism.

This collaboration across the University will serve as a first step in building a community interested in designing and promoting education innovation to improve society.

Anyone interested in education innovation and/or social justice and activism is invited!  We want to learn who is already doing this important work and identify potential collaborations across the University.

Please join us on Wednesday, May 12, 2021 from 12:00 - 1:00 PM

Register via Eventbrite

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Workshop / Seminar Tue, 20 Apr 2021 06:37:52 -0400 2021-05-12T12:00:00-04:00 2021-05-12T13:00:00-04:00 Off Campus Location RISE (Research. Innovation. Scholarship. Education.) Workshop / Seminar RISE Virtual Talking Circle
RNA Seminar featuring: Thomas Martinez, Salk Institute for Biological Studies (May 17, 2021 4:00pm) https://events.umich.edu/event/81303 81303-20881903@events.umich.edu Event Begins: Monday, May 17, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

Registration Required: https://umich.zoom.us/webinar/register/WN_90RkcQTGQZa7ifQ8kbSdNQ

KEYOWORDS: microprotein, smORF, ribosome profiling

ABSTRACT: Functional protein-coding small open reading frames (smORFs) are emerging as an important class of genes. Several smORF-encoded microproteins have been characterized and implicated in a variety of critical processes, including regulation of mRNA decay, DNA repair, and muscle formation. Thus, rigorous and comprehensive annotation of protein-coding smORFs is critical to our understanding of basic biology and physiology, as well as disease. We recently developed an improved workflow that integrates de novo transcriptome assembly and ribosome profiling to overcome obstacles with previous methods to more confidently annotate thousands of novel smORFs across multiple human cell lines, including hundreds encoded on putative non-coding RNAs. Over 1,500 smORFs are found in two or more cell lines, and ~40% lack a canonical AUG start codon. Evolutionary conservation analyses suggest that hundreds of smORF-encoded microproteins are likely functional. We also find that smORF-derived peptides are detectable on human leukocyte antigen complexes, positioning smORFs as a source of novel antigens. The annotation of protein-coding smORFs radically alters the current view of the human genome’s coding capacity and will provide a rich pool of unexplored, functional human genes.

BIO: Thomas received his B.S. in Biological Engineering from MIT and trained in Prof. JoAnne Stubbe’s laboratory, where he studied the mechanism of ribonucleotide reductase. He then recieved his Ph.D. in Biochemistry & Molecular Biophysics from Caltech as an NIH NRSA predoctoral fellow under the mentorship of Prof. Peter Dervan. His thesis work focused primarily on characterizing the effects of DNA binding pyrrole-imidazole polyamides on DNA replication in prostate cancer cells. Thomas is currently an NIH NRSA postdoctoral fellow in Prof. Alan Saghatelian’s laboratory, where he has developed an integrative platform combining ribosome profiling and de novo transcriptome assembly to discover functional smORF encoded microproteins in the human genome.

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Lecture / Discussion Wed, 14 Apr 2021 12:39:54 -0400 2021-05-17T16:00:00-04:00 2021-05-17T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Thomas Martinez, Salk Institute for Biological Studies
Health Care Reform: A Conversation with the Experts (May 20, 2021 12:00pm) https://events.umich.edu/event/84008 84008-21619391@events.umich.edu Event Begins: Thursday, May 20, 2021 12:00pm
Location: Off Campus Location
Organized By: Institute for Healthcare Policy and Innovation

Where do we stand with the Affordable Care Act and its latest U.S. Supreme Court challenge? What health care reform policies might we expect from President Joe Biden and the new Congress?

Join the U-M Institute for Healthcare Policy and Innovation as we take on these questions and more. Our experts will discuss the legal, economic, medical, and health equity challenges related to health care reform now — and into the future.

IHPI Director John Ayanian, M.D., M.P.P., moderates an expert panel discussion featuring:

Helen G. Levy, Ph.D.
Research Professor, Institute for Social Research

Minal R. Patel, Ph.D., MPH
Associate Professor of Health Behavior and Health Education, School of Public Health

Nicholas Bagley, J.D.
Professor of Law, Law School

Visit https://ihpi.umich.edu/informing-policy/healthcare-reform to learn more about IHPI members’ research on the impact of health care reform.

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Livestream / Virtual Tue, 11 May 2021 08:48:28 -0400 2021-05-20T12:00:00-04:00 2021-05-20T13:00:00-04:00 Off Campus Location Institute for Healthcare Policy and Innovation Livestream / Virtual US Capitol building
Crucial Conversations: Mental Health Awareness (May 24, 2021 12:00pm) https://events.umich.edu/event/84010 84010-21619394@events.umich.edu Event Begins: Monday, May 24, 2021 12:00pm
Location: Off Campus Location
Organized By: Public Engagement & Impact

Millions of Americans face the reality of living with a mental illness, and there are many facets of mental health impacting numerous aspects of life. During Mental Health Awareness Month and beyond, the University of Michigan is committed to increasing knowledge, reducing stigma, and fostering a supportive community.

Join this engaging live conversation with U-M experts on prioritizing mental health, educating and advocating for resources and policies, and creating an uplifting environment for yourself and those around you. Researchers from Michigan Medicine, the School of Public Health, the Depression Center, and the Department of Psychology will share their insights, advice, and tools for our community members.

Moderator:
Preeti Malani, MD, MSJ, Chief Health Officer and a Professor of Medicine in the Division of Infectious Diseases

Panelists:
Ramaswami Mahalingam, PhD, Professor of Psychology and Director of the Mindful Dignity Lab

Michelle Riba, MD, MS, Clinical Professor, Department of Psychiatry and a member of the Eisenberg Family Depression Center

John Piette, PhD, Professor in Health Behavior and Health Education and Director of the Center for Managing Chronic Disease

Caitlan DeVries, Masters of Public Health student

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Livestream / Virtual Thu, 20 May 2021 10:25:14 -0400 2021-05-24T12:00:00-04:00 2021-05-24T13:00:00-04:00 Off Campus Location Public Engagement & Impact Livestream / Virtual Crucial Conversations: Mental Health Awareness
Precision Health Webinar (May 25, 2021 1:00pm) https://events.umich.edu/event/83924 83924-21617135@events.umich.edu Event Begins: Tuesday, May 25, 2021 1:00pm
Location: Off Campus Location
Organized By: Precision Health

Precision Health at the University of Michigan (U-M) invites you to engage with two outstanding Scholars who have been funded by Precision Health to develop their research.
Arun Subramaniyan, BE, MS (graduate student, College of Engineering): “Hardware-accelerated systems for next-generation sequencing analysis”

Alyse Krausz, BS, MS (graduate student research assistant, Biomedical Engineering): “A Point-of-Care Microfluidic System for Traumatic Brain Injury Diagnosis and Prognosis”

You'll hear more about their work and how they used Precision Health resources in these innovative projects.

**Please register to attend. We will send a link to the virtual presentation a few days in advance. We hope you'll join us!**

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Livestream / Virtual Tue, 04 May 2021 13:45:53 -0400 2021-05-25T13:00:00-04:00 2021-05-25T14:00:00-04:00 Off Campus Location Precision Health Livestream / Virtual May 2021 PH Webinar
Clinical Simulation Center Brown Bag Discussion (May 25, 2021 3:00pm) https://events.umich.edu/event/84097 84097-21620331@events.umich.edu Event Begins: Tuesday, May 25, 2021 3:00pm
Location:
Organized By: Department of Learning Health Sciences

"Omni II Infant, Safe Patient Handling Obesity suit, UH Training Room and Juno-Med fidelity manikin"

Our team is planning four short lightning talks, highlighting some new equipment and additions to our courses.

This will be a Zoom meeting.
https://umich.zoom.us/j/97929340876

Dial by your location
+1 646 876 9923
Meeting ID: 979 2934 0876

Find your local number: https://umich.zoom.us/u/ac04eNX6TC

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Lecture / Discussion Tue, 25 May 2021 15:21:30 -0400 2021-05-25T15:00:00-04:00 2021-05-25T16:00:00-04:00 Department of Learning Health Sciences Lecture / Discussion Mod CCO, DLHS Clinical Simulation Center
PhD Defense: Edward Peter Washabaugh IV (May 27, 2021 10:00am) https://events.umich.edu/event/84050 84050-21619709@events.umich.edu Event Begins: Thursday, May 27, 2021 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

Injuries to the neuromusculoskeletal systems often result in muscle weakness, abnormal coordination strategies, and gait impairments. Functional resistance training during walking—where a patient walks while a device increases loading on the leg—is an emerging approach to combat these symptoms. While simple passive devices (i.e., ankle weights and resistance bands) can be applied for this training, rehabilitation robots have more potential upside because they can be controlled to treat multiple gait abnormalities and can be monitored by clinicians. However, the cost of conventional robotic devices limits their use in the clinical or home setting. Hence, in this dissertation, we designed, developed, and tested passive and semi-passive wearable exoskeleton devices as a low-cost solution for providing controllable/configurable functional resistance training during walking.


We developed and tested two passive exoskeleton devices for providing resistance to walking and tested their effects on able-bodied participants and stroke survivors. First, we created a patented device that used a passive magnetic brake to provide a viscous (i.e., velocity-dependent) resistance to the knee. The resistive properties of the device could be placed under computer control (i.e., made semi-passive) to control resistance in real-time. Next, we created a passive exoskeleton that provided an elastic (i.e., position-dependent) resistance. While not controllable, this device was highly configurable. Meaning it could be used to provide resistance to joint flexion, extension, or to both (i.e., bidirectionally). Human subjects testing with these devices indicated they increased lower-extremity joint moments, powers, and muscle activation during training. Training also resulted in significant aftereffects—a potential indicator of therapeutic effectiveness—once the resistance was removed. A separate experiment indicated that individuals often kinematically slack (i.e., reduce joint excursions to minimize effort) when resistance is added to the limb. We also found that providing visual feedback of joint angles during training significantly increased muscle activation and kinematic aftereffects (i.e., reduced slacking).


With passive devices, the type of passive element used largely dictates the muscle groups, types of muscle contraction, joint actions, and the phases of gait when a device is able to apply resistance. To examine this issue, we compared the training effects of viscous and elastic devices that provided bidirectional resistance to the knee during gait. Additionally, we compared training with viscous resistances at the hip and knee joints. While the resistance type and targeted joint altered moments, powers, and muscle activation patterns, these methods did not differ in their ability to produce aftereffects, alter neural excitability, or induce fatigue in the leg muscles. While this may indicate that the resistance type does not have a large effect on functional resistance training during walking, it is possible that an extended training with these devices could produce a different result.


Lastly, we used musculoskeletal modeling in OpenSim to directly compare several strategies that have been used to provide functional resistance training to gait in the clinic or laboratory setting. We found that devices differed in their ability to alter gait parameters during walking. Hence, these findings could help clinicians when selecting a resistive strategy for their patients, or engineers when designing new devices or control schemes.



Date: Thursday, May 27, 2021

Time: 10:00 AM

Zoom: https://umich.zoom.us/meeting/register/tJIufumrrDgtHd3z5Jg3Y_BG4ZC70OPrjTjk (Zoom link requires prior registration)

Chair: Dr. Chandramouli Krishnan

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Lecture / Discussion Fri, 14 May 2021 13:49:26 -0400 2021-05-27T10:00:00-04:00 2021-05-27T11:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Getting Engaged in Campus Education Innovation Activities (June 9, 2021 12:00pm) https://events.umich.edu/event/84084 84084-21619928@events.umich.edu Event Begins: Wednesday, June 9, 2021 12:00pm
Location: Off Campus Location
Organized By: RISE (Research. Innovation. Scholarship. Education.)

Our next Virtual Talking Circle (VTC) will feature representatives from several units on campus that are leading the way in cultivating education innovation: The Center for Academic Innovation (CAI), Fast Forward Medical Innovation (FFMI), and the International Mixed Reality Grand Rounds.

Join us on Wednesday, June 9, 2021 from 12:00 - 1:00 PM to learn more about these units and how you can get involved in their education innovation activities. We hope you will also share other education innovation resources available to faculty, staff and learners.

All are welcome!

Register via Zoom at: https://umich.zoom.us/webinar/register/WN_xVYKDuaYSXa6AevHutqXBA

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Workshop / Seminar Thu, 20 May 2021 06:44:41 -0400 2021-06-09T12:00:00-04:00 2021-06-09T13:00:00-04:00 Off Campus Location RISE (Research. Innovation. Scholarship. Education.) Workshop / Seminar RISE Virtual Talking Circle
RNA Innovation Seminar featuring Rising Scholars: Khan & McMillan (June 14, 2021 4:00pm) https://events.umich.edu/event/83934 83934-21619166@events.umich.edu Event Begins: Monday, June 14, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

Registration Required: https://umich.zoom.us/webinar/register/WN_uLz-ONHVQPuRINMYUNvBJQ

“CCR5 as a model to examine reporter assays in evaluating translational phenomena”
Yousuf Khan
Knight-Hennessy Scholar
Stanford University

KEYWORDS: dual luciferase, frameshifting, recoding, CCR5
ABSTRACT: During the decoding of a subset of mRNAs, a proportion of ribosomes productively shift to the −1 reading frame at specific slippage-prone sites in a phenomenon known as programmed −1 ribosomal frameshifting (−1 PRF) to generate a frameshifted, C-terminally unique protein. The first experimentally verified occurrence of functionally utilized non-retroelement derived −1 PRF in humans has been reported in the mRNA encoding the immune-functioning C-C chemokine receptor 5 (CCR5). Here, we show that frameshifting does not occur during CCR5 decoding. Apart from its importance in understanding expression of a gene relevant to cancer, an HIV-1 receptor (and the associated claimed rationale for generating the first humans derived from genetically modified embryos), the findings imply that caution is appropriate in assessing results from translational reporter assays.

~and~

“Intersection between RNA methylation and TDP43-mediated toxicity in ALS”
Michael McMillan
Ph.D. candidate
Cellular and Molecular Biology
University of Michigan

KEYWORDS: TDP43, m6A, ALS, RNA stability
ABSTRACT: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease resulting in the death of upper and lower motor neurons. ALS has no known cure and limited therapeutic options, and the underlying pathological mechanisms remain unclear. Despite considerable variability in clinical presentation, over 95% of ALS cases exhibit cytoplasmic inclusions of the RNA binding protein TDP43. Emerging evidence suggests that TDP43 is crucial for RNA stability, and that dysregulation of RNA homeostasis may contribute to ALS pathogenesis.
Methylation of RNA at the 6th position nitrogen (N6-methyladenosine methylation, or m6A) by methyltransferases (writers) or removal of methyl groups by demethylases (erasers) has dramatic effects on RNA stability and translation mediated by a family of RNA biding proteins that recognize methylated RNA (readers). m6A writers and erasers specifically localize to nuclear speckles, membraneless nuclear organelles rich in RNA binding proteins and splicing factors, including TDP43. Together with our data showing that TDP43 regulates RNA stability, these observations suggest that TDP43 may destabilize m6A modified RNA. Here, we show that methylated RNA co-purified with TDP43 from cultured cells via RNA immunoprecipitation, and abrogation of methylation sites disrupted TDP43 binding, suggesting that TDP43 recognizes m6A modified RNA in cellulo. We also noted profound and widespread hypermethylation of coding and non-coding transcripts in ALS spinal cord, many overlapping with confirmed TDP43 target transcripts. Consistent with a central role for m6A modification in TDP43-mediated toxicity, we identified several factors operating within the m6A pathway that enhance or suppress the toxicity of TDP43 in rodent primary cortical neurons via a single-cell CRISPR/Cas9 candidate-based screen. Genetic knockout of the established m6A reader YTHDF2 rescued TDP43 toxicity in primary neurons, and YTHDF2 was also upregulated in ALS postmortem sections. Together, these data imply a fundamental link between m6A RNA modifications and ALS pathogenesis, potentially mediated by TDP43-dependent RNA destabilization.

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Lecture / Discussion Tue, 18 May 2021 14:31:45 -0400 2021-06-14T16:00:00-04:00 2021-06-14T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Yousuf Khan (Stanford) & Mike McMillan (U-M)
Clinical Simulation Center Brown Bag Discussion (June 15, 2021 12:00pm) https://events.umich.edu/event/84097 84097-21620084@events.umich.edu Event Begins: Tuesday, June 15, 2021 12:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

"Omni II Infant, Safe Patient Handling Obesity suit, UH Training Room and Juno-Med fidelity manikin"

Our team is planning four short lightning talks, highlighting some new equipment and additions to our courses.

This will be a Zoom meeting.
https://umich.zoom.us/j/97929340876

Dial by your location
+1 646 876 9923
Meeting ID: 979 2934 0876

Find your local number: https://umich.zoom.us/u/ac04eNX6TC

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Lecture / Discussion Tue, 25 May 2021 15:21:30 -0400 2021-06-15T12:00:00-04:00 2021-06-15T13:00:00-04:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion Mod CCO, DLHS Clinical Simulation Center
Precision Health Graduate Certificate Program - Information Session (June 17, 2021 1:00pm) https://events.umich.edu/event/84199 84199-21620752@events.umich.edu Event Begins: Thursday, June 17, 2021 1:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Plan to attend this information session to learn more about the growing field of precision health which seeks to tailor health care for individuals via a multidisciplinary, data-driven approach.

The new U-M Precision Health Graduate Certificate Program has arrived to educate current and future practitioners and researchers in this emerging field so they can become better equipped to customize patient care.

**Only 12 credits of graduate coursework required
**Great opportunity for graduate students to design their own plan
**Network with other precision health students and faculty at seminars and professional development workshops
**Mentoring with faculty

The certificate is open to all graduate students enrolled at U-M. Application deadline is August 1.

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Other Thu, 03 Jun 2021 10:50:45 -0400 2021-06-17T13:00:00-04:00 2021-06-17T13:30:00-04:00 Off Campus Location Department of Learning Health Sciences Other learners and researchers in lab, classroom and research settings
Personal Statements 101: Let's Talk Shop (June 22, 2021 9:00am) https://events.umich.edu/event/84093 84093-21620026@events.umich.edu Event Begins: Tuesday, June 22, 2021 9:00am
Location: Off Campus Location
Organized By: Writing Consulting at Newnan

Meet the Newnan Writing Consultants, and invited specialized advisors, for general advice on framing and drafting your personal statement. While we will be unable to review individual writing at this session, you will be able to pose your questions and concerns (anonymously, if you wish), to the group, regarding personal statements for graduate, medical or law schools. For next steps, students will be directed to other resources and personal statement support on campus.

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Livestream / Virtual Tue, 08 Jun 2021 15:01:33 -0400 2021-06-22T09:00:00-04:00 2021-06-22T10:00:00-04:00 Off Campus Location Writing Consulting at Newnan Livestream / Virtual reflect_mirror_stick_fig
PhD Defense: Jiayue Cao (June 23, 2021 3:00pm) https://events.umich.edu/event/84287 84287-21621035@events.umich.edu Event Begins: Wednesday, June 23, 2021 3:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

The stomach and brain interact closely with each other. Their interactions are central to digestive functions and the “gut feeling”. The neural pathways that mediate the stomach-brain interactions include the vagus nerve and the thoracic nerve. Through these nerves, the stomach can relay neural signals to a number of brain regions that span a central gastric network. This gastric network allows the brain to monitor and regulate gastric physiology and allows the stomach to influence emotion and cognition. Impairment of this gastric network may lead to both gastric and neurological disorders, e.g., anxiety, gastroparesis, functional dyspepsia, and obesity. However, the structural constituents and functional roles of the central gastric network remain unclear. In my dissertation research, I leveraged complementary techniques to characterize the central gastric network in rats across a wide range of scales and different gastric states. In animal experiments, I used functional magnetic resonance imaging (fMRI) to map brain activity synchronized with gastric electrical activity and to map brain activations induced by electrical stimulation applied to the cervical vagus or its afferent terminals on the stomach. I also used neurophysiology to characterize gastric neurons in brainstem in response to gastric electrical stimulation. Results from my studies suggest that 1) gastric neurons in the brainstem are selective to the orientation of muscle activity relayed through intramuscular arrays, 2) the central gastric network is intrinsically coupled to gastric slow waves and their amplitude fluctuations primarily via vagal signaling, 3) selective stimulation of the vagus can evoke widespread and fast brain responses and alter functional connectivity within and beyond the central gastric network. My dissertation research contributes to the foundation of mapping and characterizing the central and peripheral mechanisms of gastric interoception and sheds new light on where and how to stimulate the peripheral nerves to modulate stomach-brain interactions.



Date: Wednesday, June 23, 2021

Time: 3:00 PM

Zoom: https://umich.zoom.us/j/2757414653

Chair: Dr. Zhongming Liu

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Lecture / Discussion Tue, 15 Jun 2021 23:04:33 -0400 2021-06-23T15:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
PhD Defense: Eric Charles Hobson (June 24, 2021 10:30am) https://events.umich.edu/event/84237 84237-21620794@events.umich.edu Event Begins: Thursday, June 24, 2021 10:30am
Location: Off Campus Location
Organized By: Biomedical Engineering

Mechanical testing of viscoelastic biomaterials is of critical importance in biomedical engineering, enabling basic research into the role of the extracellular matrix, investigatory and diagnostic testing of tissues and biofluids, and the development and characterization of tissue engineered therapeutics. Conventional material testing approaches used for soft biomaterials generally require force application through direct contact with a sample, leading to potential contamination and damage, and thereby limiting these approaches to end-point measurements. To overcome these limitations, we have developed a new measurement technique, Resonant Acoustic Rheometry (RAR), which enables high-throughput, quantitative, and non-contact viscoelastic characterization of biomaterials, soft tissues, and biological fluids.



RAR uses ultrasonic pulses to both generate microscale perturbations and measure the resulting resonant oscillations at the surface of soft materials using standard labware. Resonant oscillatory properties obtained from the frequency spectra of the surface oscillations, including the resonant frequency and the damping coefficient, are used to quantify material properties such as shear modulus, shear viscosity, and surface tension in both viscoelastic solids and liquids.



We developed a prototype RAR system and tested it on a range of soft biomaterials, with shear moduli ranging from under 100 Pa to over 50 kPa, including fibrin, gelatin, and polyethylene glycol (PEG). Shear moduli measured using RAR were validated both computationally using finite element analysis and experimentally using conventional shear rheometry, with excellent linear correlation in measured elasticity between techniques (R2 > 0.95). By performing parallel RAR experiments using microwells of different sizes, we verified that resonant oscillatory behaviors could be used to quantify the intrinsic viscoelastic properties of a material. We also demonstrated the rapid, non-contact monitoring of changes in material properties over a variety of temporal scales, ranging from processes occurring on the order of milliseconds to those occurring over hours and days. High temporal resolution RAR measurements, with sampling intervals as low as 0.2 seconds, were used to characterize the gelation process. Characteristic features of the resonant surface waves during phase transition were applied to identify the gel point for various hydrogels. High sample throughput was demonstrated by performing longitudinal RAR testing to explore the impact of hydrogel polymer and crosslinker concentration on both reaction kinetics and final mechanical properties in full factorial experiments consisting of over 15,000 unique measurements. We were able to identify individual effects of design parameters as well as interactions that led to unexpected mechanical properties, demonstrating the importance of combinatorial methods and high-throughput mechanical characterization in material design.



These studies demonstrate that RAR can rapidly and accurately assess the mechanical properties of soft viscoelastic biomaterials. The measurements generated are analogous to those produced using conventional mechanical testing, and RAR is further capable of longitudinal viscoelastic studies over time. RAR applies automation in both data collection and analysis, allowing high throughput measurement of an array of samples without contact or the need for manual intervention. Furthermore, RAR uses standard microwell plates, which simplifies sample preparation and handling. The viscoelastic properties of soft biomaterials are relevant in a wide range of applications, including for clinical diagnostic assays and the development of hydrogel materials for regenerative medicine. RAR represents a fast, accurate, and cost-effective method for materials characterization in these applications.



June 24 - 10:30 AM

Zoom: https://umich.zoom.us/meeting/register/tJcsd-iurTosGdNn_gR-FbOCe5TUR09Y58WV

Co-Chairs: Dr. Cheri Deng and Dr. Jan Stegmann

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Lecture / Discussion Tue, 22 Jun 2021 16:37:33 -0400 2021-06-24T10:30:00-04:00 2021-06-24T11:30:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
LHS Collaboratory-Summer Workshop (June 24, 2021 1:00pm) https://events.umich.edu/event/83809 83809-21538171@events.umich.edu Event Begins: Thursday, June 24, 2021 1:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

This virtual workshop will review the basic concepts behind Learning Health Systems including the learning cycle, infrastructure, and learning communities.  Participants will engage in a collaborative activity to design a learning cycle.

Registration for this virtual event is limited-
please register early!

Charles P. Friedman

Department Chair of Learning Health Sciences
Josiah Macy Jr. Professor of Medical Education
Professor of Information
Professor of Public Health
University of Michigan

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Workshop / Seminar Tue, 20 Apr 2021 10:17:48 -0400 2021-06-24T13:00:00-04:00 2021-06-24T16:00:00-04:00 Off Campus Location Department of Learning Health Sciences Workshop / Seminar LHS Collaboratory logo
BME Master's Defense: Spencer Morris (June 28, 2021 10:00am) https://events.umich.edu/event/84342 84342-21623372@events.umich.edu Event Begins: Monday, June 28, 2021 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

Acquiring accurate measurements for blood flow is a clinically relevant problem of interest. Three-dimensional color flow with partial volume correction (PVC) is a relatively new method for measuring blood flow that accounts for beams located partially outside of the blood vessel. Recent work has shown that the relationship between color flow power and partially perfused voxels is nonlinear. This work investigates the statistics of color power measurements in simulated plug flow to help explain this nonlinear behavior. Data was acquired using Field II simulations in which a 3.75 MHz mechanically swept linear array obtained RF data of blood moving through a vessel. Blood in the vessel exhibited plug flow, and tissue backscatter was set to 40 dB below blood. The statistics of color power at each point in the processing chain were analyzed using histograms, established results in ultrasound statistics, and derived probability density functions (pdfs). For locations completely inside the beam, power before additional processing showed exponential behavior, whereas the square root of power, i.e., amplitude, was Rician distributed. After implementing the Kasai algorithm, the power values could be estimated with a gamma distribution with a shape parameter of 2.21. Kasai powers corresponding to tissue could also be fitted with a gamma distribution, albeit with a shape parameter close to 1, indicating close to exponential behavior. Kasai powers for partial volume data were intermediate between the tissue and blood data. A method for estimating partial volume weight from the skewness and kurtosis of samples taken from the same location is also discussed.

Date: Monday, June 28, 2021
Time: 10:00 AM
Zoom: https://umich.zoom.us/j/97162930417
Chair: Dr. Oliver Kripfgans

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Presentation Tue, 22 Jun 2021 11:48:21 -0400 2021-06-28T10:00:00-04:00 2021-06-28T11:00:00-04:00 Off Campus Location Biomedical Engineering Presentation BME Event
RNA Collaborative Seminar (June 30, 2021 4:00pm) https://events.umich.edu/event/84166 84166-21620522@events.umich.edu Event Begins: Wednesday, June 30, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_6OEQ6sDAQ0-21GHm6d7VEQ

“Dynamic multivalent interactions drive mammalian RNA regulation”
Sethu Pitchiaya, Ph.D.
Dept of Urology

and

"Characterizing cellular RNA-protein interaction networks with chemical probes"
Chase Weidmann, Ph.D.
Dept of Biological Chemistry

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Lecture / Discussion Wed, 09 Jun 2021 15:28:29 -0400 2021-06-30T16:00:00-04:00 2021-06-30T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Sethu Pitchiaya & Chase Weidmann
Examining the Risk of Potentially Preventable Hospitalization in Adults with Congenital and Acquired Disabilities (July 8, 2021 2:00pm) https://events.umich.edu/event/84312 84312-21623271@events.umich.edu Event Begins: Thursday, July 8, 2021 2:00pm
Location: Off Campus Location
Organized By: Inter-university Consortium for Political and Social Research

Link to registration: https://umich.zoom.us/webinar/register/WN_0EcJEoE7QP-KtRCtxJnRqw

Adults with pediatric-onset (cerebral palsy/spina bifida (CP/SB)) or acquired disabilities (spinal cord injury (SCI) or multiple sclerosis (MS)) are more likely than those without disability to develop medical complications. Little is known about potentially preventable hospitalizations (PPH) among adults with disabilities. PPHs are preventable if a patient had timely access to care. The objective of this study was to examine potential risk and protective factors for PPH, comparing adults with aforementioned disabilities to people without. Our results indicate that adults with disabilities were at greater odds for PPH compared to people without disabilities. Use of preventative services such as annual wellness visit had substantial protective association against PPH. Attendees will learn: (1) how to work with administrative claims data and medical codes to identify appropriate case and control groups; (2) how to define covariates and outcome measures in claims data; (3) how to use various modeling techniques to test a hypothesis; (4) how to interpret the results and develop policy implications.

This webinar is free and open to the public. Communication Access Realtime Translation services will be available to provide live closed captions for the event.

The content of this webinar has been developed under a grant from the National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR #90RTHF0001). NIDILRR is a Center within the Administration for Community Living (ACL), Department of Health and Human Services (HHS). The contents of this webinar do not necessarily represent the policy of NIDILRR, ACL, or HHS and you should not assume endorsement by the Federal Government.

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Presentation Thu, 17 Jun 2021 18:07:45 -0400 2021-07-08T14:00:00-04:00 2021-07-08T15:00:00-04:00 Off Campus Location Inter-university Consortium for Political and Social Research Presentation IDEAL RRTC July 8 2021 Webinar
PhD Defense: Hans Zander (July 9, 2021 9:00am) https://events.umich.edu/event/84346 84346-21623406@events.umich.edu Event Begins: Friday, July 9, 2021 9:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

Spinal cord stimulation (SCS) is a neuromodulation technique that applies electrical stimulation to the spinal cord to alter neural activity or processing. While SCS has historically been used as a last resort therapy for chronic pain management, novel applications and technologies have recently been developed that either increase the efficacy of treatment for chronic pain or drive neural activity to produce muscular activity/movement following a paralyzing spinal cord injury (SCI). Despite these recent innovations, there remain fundamental questions concerning the neural recruitment underlying these efficacious results. This work evaluated the neural activity and mechanisms for two novel SCS applications: closed-loop spinal cord stimulation for pain management, and ventral, high frequency spinal cord stimulation (HF-SCS) for inspiratory muscle activation following a SCI.

To evaluate neural activity, I developed computational models of SCS. Models consisted of 3 components: a finite element model (FEM) of the spinal cord to predict voltages during stimulation, biophysical neuron models, and algorithms to apply time-dependent extracellular voltages to the neuron models and simulate their response. While this cutting-edge modeling methodology could be used to predict neural activity following stimulation, it was unclear how common anatomical or technical model simplifications affected neural predictions. Therefore, the initial goal of this work was to evaluate how modeling assumptions influence neural behavior.

My initial work identified how several relevant anatomical and technical factors influence model predictions of neural activity. To evaluate these factors, I designed an FEM of a T9 thoracic spine with an implanted electrode. Then, I sequentially removed details from the model and quantified the changes in neural predictions. I identified several factors with profound (>30%) impacts on neural thresholds, including overall model impedance (for voltage-controlled stimulation), the presence of a detailed vertebral column, and dura mater conductivity. I also identified several factors that could safely be ignored in future models. This work will be invaluable as a guide for future model development.

Next, I developed a canine model to evaluate T2 ventral HF-SCS for inspiratory muscle activation. I designed and positioned two neuron models hypothesized to lead to inspiratory behavior: ventrolateral funiculus fibers (VLF) leading to diaphragm activation and inspiratory intercostal motoneurons. With this model, I predicted robust VLF and T2-T5 motoneuron recruitment within the physiologic range of stimulation. Additionally, I designed two stimulation leads that maximize inspiratory neuron recruitment. The finalized leads were evaluated via in vivo experiments, which found excellent agreement with the model. This work builds our mechanistic understanding of this novel therapy, improves its implementation, and aids in future translational efforts towards human subjects.

Finally, I developed a computational model to evaluate closed-loop stimulation for chronic pain. This work characterized the neural origins of the evoked compound action potential (ECAP), the controlling biomarker of closed-loop stimulation. I modified my modeling methodology to predict ECAPs generated during low thoracic dorsal stimulation in humans, which matched with experimental measurements. This modeling work showed that ECAP properties depend on activation of a narrow range of neuron diameters and quantified how anatomical and stimulation factors (CSF thickness, stimulation configuration, lead position, pulse width) influence ECAP morphology, timing, and neural recruitment. These results improve our mechanistic understanding of closed-loop stimulation and may lead to expanded clinical utility as well as better validation of future SCS computational models.

Date: Friday, July 9, 2021

Time: 9:00 AM EDT

Zoom: https://umich.zoom.us/j/96847307388

Chair: Dr. Scott Lempka

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Lecture / Discussion Tue, 22 Jun 2021 16:45:26 -0400 2021-07-09T09:00:00-04:00 2021-07-09T10:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
BME Ph.D. Defense: Michael Bregenzer (July 21, 2021 9:00am) https://events.umich.edu/event/84438 84438-21623984@events.umich.edu Event Begins: Wednesday, July 21, 2021 9:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

High grade serous ovarian cancer (HGSOC) is the deadliest gynecological malignancy. Despite successful first line therapies, most patients relapse and develop more chemoresistant disease. This recurrence and development of chemoresistance is attributed to a rare population of tumor cells, termed cancer stem cells (CSCs), which are more chemoresistant, have the capacity to self-renew, and can repopulate the entire tumor. Research has shown that CSCs are maintained by the non-cancer cells in the tumor microenvironment (TME), such as mesenchymal stem cells (MSCs), endothelial cells (ECs), and immune cells. Furthermore, the role of non-cancer cells in clinical outcomes and chemoresistance has been highlighted by recent evidence showing that classification of HGSOC molecular subtypes, which have variable clinical prognoses, are influenced by the presence of non-cancer cells in the tumor. However, it is currently unclear exactly how CSCs and the nuanced cell composition of the TME work together to promote chemoresistance. Current models used to study these phenomena either suffer from a lack of cellular complexity in the case of many in vitro models or impractical experimental constraints such as long latency periods and poor control over cell composition in patient-derived xenografts. To better understand the role of CSCs and the TME cells in chemoresistance, practical in vitro model systems that more closely represent in vivo processes and microenvironments are needed. We hypothesize that the development of these in vitro model systems will contribute novel insights into TME-mediated CSC regulation and the development of chemoresistance in HGSOC.

In aim 1 we examined the emergence of chemoresistance in the context of CSCs by developing a 3D in vitro serial passaging model system that allows for long term culture of patient-derived tumor cells with periodic evaluation of stemness and chemoresistance. Using this model system, we demonstrated increased proliferation, expression of CSC markers, tumorigenicity, and chemoresistance over the course of long-term passaging, reflective of emerging chemoresistance in vivo. Furthermore, this system enabled us to define a malignant gene expression signature that is associated with chemoresistance, tumorigenicity, and stemness and to evaluate patient-specific chemoresistance development following treatment. Finally, we demonstrated the translational value of this model system by showing that Metformin treatment can hinder CSC driven development of chemoresistance in a phase II clinical trial.

In aim 2 we developed a heterogeneous tumoroid culture system that enabled culture of patient-derived tumor cells with controlled ratios of MSCs, ECs, and immune cells to study TME-mediated maintenance of CSCs and chemoresistance. Using this model, we found that changes in CD133+/-ALDH+/- CSC phenotypes in response to TME cells varied depending on the patient sample. We also observed increased tumorigenicity and chemoresistance in tumoroids compared to spheroids cultured with patient-derived tumor cells alone. Furthermore, we found evidence of epithelial-to-mesenchymal transition (EMT) in tumoroids accompanied by altered CSC phenotypes and a malignant matrisome signature. All of this together supports idea that the non-cancer cells in the TME contribute to the development of advanced, chemoresistant disease and implicates EMT, changes in CSC phenotypes, and matrix remodeling as the primary culprits.

Finally, in aim 3, we utilized this tumoroid system to generate tumoroids with 23 different cell compositions to evaluate the role of TME cell composition in response to therapy. Drug assays with novel and traditional chemotherapies revealed that tumoroids with different compositions respond differently to therapy and that the number of monocytes included in the culture was associated with the greatest resistance to therapy. Furthermore, our random forest models trained on the drug responses of each cell composition were able to predict drug response with moderate success. With these models we identified that nuanced differences in cell composition can influence drug response and that the strongest predictor of response to therapy was the total quantity of non-cancer cells. Overall, this model demonstrates the potential of using the TME composition to predict patient drug response and direct clinical management.

In these aims we demonstrate the clear utility of complex and realistic, yet practical in vitro model systems in the study of chemoresistance and CSC maintenance in ovarian cancer. Specifically, we identified the link between CSCs and the development of chemoresistance in long term 3D in vitro serial passage culture. Furthermore, we showed that the non-cancer cells in the TME can confer chemoresistance and promote EMT associated with altered CSC phenotypes and matrix remodeling. Lastly, we demonstrated the potential of TME composition in predicting drug response. Overall, the model systems presented in this study provide platforms that can be used to better understand the role of CSCs and the TME in chemoresistance and poor clinical outcomes. This could ultimately lead to the development of novel therapies, enhanced clinical management, and improved clinical outcomes.

Date: Wednesday, July 21, 2021
Time: 9:00 AM
Zoom: https://umich.zoom.us/j/96111622879
Password: 326862
Chair: Dr. Geeta Mehta

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Presentation Mon, 12 Jul 2021 12:13:44 -0400 2021-07-21T09:00:00-04:00 2021-07-21T10:00:00-04:00 Off Campus Location Biomedical Engineering Presentation BME Event
Precision Health Graduate Certificate Program (July 22, 2021 1:00pm) https://events.umich.edu/event/84318 84318-21623289@events.umich.edu Event Begins: Thursday, July 22, 2021 1:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

The new U-M Precision Health Graduate Certificate Program has arrived to educate current and future practitioners and researchers in this emerging field so they can become better equipped to customize patient care.

**Only 12 credits of graduate coursework required
**Great opportunity for graduate students to design their own plan
**Network with other precision health students and faculty at seminars and professional development workshops

**Mentoring with faculty

The certificate is open to all graduate students enrolled at U-M. Application deadline is August 1.

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Presentation Fri, 18 Jun 2021 14:24:55 -0400 2021-07-22T13:00:00-04:00 2021-07-22T13:30:00-04:00 Off Campus Location Department of Learning Health Sciences Presentation researchers, learners and health professional in lab, classroom and clinic setting
Precision Health Graduate Certificate Program - Information Session (July 22, 2021 1:00pm) https://events.umich.edu/event/84201 84201-21620757@events.umich.edu Event Begins: Thursday, July 22, 2021 1:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Plan to attend this information session to learn more about the growing field of precision health which seeks to tailor health care for individuals via a multidisciplinary, data-driven approach.

The new U-M Precision Health Graduate Certificate Program has arrived to educate current and future practitioners and researchers in this emerging field so they can become better equipped to customize patient care.

**Only 12 credits of graduate coursework required
**Great opportunity for graduate students to design their own plan
**Network with other precision health students and faculty at seminars and professional development workshops
**Mentoring with faculty

The certificate is open to all graduate students enrolled at U-M. Application deadline is August 1.

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Other Thu, 03 Jun 2021 11:00:29 -0400 2021-07-22T13:00:00-04:00 2021-07-22T13:30:00-04:00 Off Campus Location Department of Learning Health Sciences Other learners and researchers in lab, classroom and research settings
BME Ph.D. Defense: Yuan Li (July 22, 2021 2:00pm) https://events.umich.edu/event/84452 84452-21624017@events.umich.edu Event Begins: Thursday, July 22, 2021 2:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults and has a poor prognosis with a median survival of approximately 14 months. Clinical standard assessment of therapy response and tumor progression is based upon post-contrast T1-weighted (T1W) and fluid-attenuated inversion recovery (FLAIR) T2-weighted (T2W) magnetic resonance images (MRI).  However, contrast enhancement observed on the post-contrast T1W MRI is affected not only by tumor growth but also effects of radiation, anti-angiogenesis drugs and chemotherapy, due to the fact that it represents blood-brain barrier disruption. Another problem is that abnormality on T2W FLAIR images is influenced by T2 changes of tumor cells as well as edema and necrosis that always co-exist within GBM. Diffusion weighted (DW) imaging has been proposed to overcome these limitations. Conventional DW images quantify apparent diffusion coefficient (ADC) with b-values between 0 and 1000 s/mm2 using a mono-exponential decay. One limitation is that co-existence of edema in clinical GBM elevates ADC.
 
In diffusion MRI, there are three dimensions of parameter spaces that we could explore in research —b value, diffusion time (t) and echo time (TE). Hence, we investigated and developed high order diffusion models in these three spaces and evaluated whether they could reveal more features of GBM.
 
In the b-value space, we investigated a microstructure model (MSM), in which modulation of diffusion gradient with cell size is considered, with high b-value diffusion images in the patients with GBM pre-radiation therapy (RT). We found apparent cell size (ARS), extracellular diffusion coefficient (Dex) and intracellular fractional volume (Vin) in tumor were significantly greater than ones in normal tissue and edema. In addition, we investigated diffusion kurtosis imaging (DKI) in GBM pre-RT and mid-RT, and found pre-RT mean kurtosis of the tumor could provide a predictive value of overall survival (OS) additional to clinical prognostic factors.
 
In the TE space, T2-Relaxation-Diffusion correlation experiments can be powerful in resolving water compartments with respect to their size and chemical composition, but the problem is ill-posed. We simplified the T2-Relaxation-Diffusion correlation to consider the T2 values and diffusion coefficients in a 2x2 fashion. We found that there were significant differences between fast and slow diffusion coefficients and between associated T2 values in tumor, cortex, deep GM, and edema. Multivariate Cox model showed the fractional volume of slow component (Vs) mid-RT may add a predictive value to clinical factors.
 
In diffusion time space, we applied three different diffusion times using pulsed diffusion gradients (PG) and oscillating gradients at frequencies of 30 Hz (OS30) and 50 Hz (OS50) using a prototype sequence. Using a random walk with barriers model, we estimated cell diameter, unrestricted diffusion coefficient (D0) at a short time limit, bulk diffusion coefficient (Dinf) at a long time limit, cell membrane permeability and effective restriction in the contrast-enhanced tumor. Those parameters provide microstructural information in the GBM and need to be further investigated and validated with pathology.
 
Previous studies have mainly investigated high order diffusion models in prostate cancer and xenograft tumor models, and only a few studies investigated GBM. The current knowledge about the relationship between model parameters and physiological/pathological features in GBM are still limited. Our research in GBM could lead to better imaging means for GBM diagnosis, tumor target definition for radiation therapy, and therapy response assessment.
 
Date: Thursday, July 22, 2021
Time: 2:00 PM
Zoom: https://umich.zoom.us/j/96213084276

Chair: Dr. Yue Cao

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Presentation Tue, 13 Jul 2021 13:47:02 -0400 2021-07-22T14:00:00-04:00 2021-07-22T15:00:00-04:00 Off Campus Location Biomedical Engineering Presentation BME Event
BME PhD Defense: Emine Sumeyra Turali-Emre (August 2, 2021 1:00pm) https://events.umich.edu/event/84794 84794-21624994@events.umich.edu Event Begins: Monday, August 2, 2021 1:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Biomimetic nanoparticles (NPs) are bio-inspired inorganic nanoscale materials that replicate some biological nanostructures functionalities including self-assembly, catalysis, and enzyme inhibition. These functionalities are being investigated for and, in some cases, are being utilized in optics and electronics such as chemical sensors, superhydrophobic coatings, and antireflective surfaces. This thesis examines the utilization of biomimetic inorganic NPs for various problems in biomedical engineering.

Specifically, in the first part of this thesis, I address the problem on controversial explanations of the antibacterial and other biological activity of zinc oxide NPs that are frequently utilized in cosmetics, textiles, and biomedical fields. In the second part of the thesis, I explore the self-organization of NPs into biomimetic supraparticles (SPs) for nucleic acid delivery that can be exploited as drug delivery agents.

NPs have been used in the antimicrobial field for a long time; however, their antibacterial mechanism of action against different types of bacteria remains unclear and, in many cases, misinterpreted. Most of the studies on antimicrobial NPs suggest reactive oxygen species (ROS) formation, ion release, and membrane damage as the primary source of antibacterial activity. In Chapter 2, we show that the mechanism of antibacterial activity for Staphylococcus aureus is remarkably more complex than generating ROS or the release of Zn2+ ions and is based on formation of biomimetic complexes of NPs with proteins. Gene expression analysis demonstrated that ZnO-NPs significantly affect carbohydrate metabolism and cell energetics, where the uridine monophosphate (UMP) biosynthesis pathway is highly upregulated. In Chapter 3, we explore the ZnO-NP mode of entry into S. aureus and the cell metabolism. Here, we showed that NPs enter the cells within 5 minutes of exposure and induce minimal membrane damage. We note that cells do not depolarize until 60 min post-NPs exposure. Thereby, we highlight that membrane damage is not the primary mechanism of action but rather a downstream effect of ZnO-NPs exposure to bacterial cells. Taken together, causing minimal ROS production and significant changes in carbohydrate metabolism and bioenergetics along with cell entry without immediate membrane damage imply the biomimetic function of these NPs. Further investigation into the antimicrobial mechanisms of biomimetic NPs is essential for future clinical translation.

Over the past few decades, there has been considerable interest in developing nanoscale constructs as effective delivery tools for high molecular weight drugs. In chapter 4, I explore the self-assembly of NPs into compartmentalized SPs, which mimics the structure of a virus to deliver nucleic acid into cells. The time-dependent self-assembly mechanism reveals that these SPs are formed from nanocup intermediates. We found that this intermediate stage is essential for the utilization of SP compartments. Nucleic acid is added to the system at this stage before SP formation, and high encapsulation is achieved. Similar to virus infections, once cells uptake the SP, SP disassociates in endosomes and releases the cargo.

Overall, the work presented in this thesis investigates and highlights the strong potential of biomimetic inorganic NPs use in next-generation biomedical applications.

Date: Monday, August 2, 2021
TIme: 1:00PM
Zoom: https://umich.zoom.us/j/95043183845
Chair: Prof. Nicholas Kotov

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Presentation Wed, 28 Jul 2021 12:34:40 -0400 2021-08-02T13:00:00-04:00 2021-08-02T14:00:00-04:00 Off Campus Location Biomedical Engineering Presentation BME Event
BME PhD Defense: Daniel Clough (August 4, 2021 10:00am) https://events.umich.edu/event/84844 84844-21625176@events.umich.edu Event Begins: Wednesday, August 4, 2021 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

Type 1 diabetes is caused by the autoimmune destruction of insulin-producing β-cells, resulting in a chronic metabolic disorder typically treated with exogenous insulin. Even with the aid of advanced insulin pumps and real time feedback systems, blood glucose levels still deviate outside of the range maintained by native islets, which places the individual at risk for vascular complications and life-threatening hypoglycemic events. Cell replacement therapies have demonstrated the capacity to tightly control blood glucose levels. The wide adoption of cell replacement therapy is hindered by limited availability of donor islets, and the lack of effective methods to support the long-term function of these cells within a clinically accessible site. The results presented in this thesis address these limitations: through studying maturation of human pluripotent progenitor cell (hPPC) derived β cells within a transplantable biomaterial platform, and evaluating novel approaches to the implantation and support of these cells during their continued maturation in vivo.

First, I present a study that examined delivery of hPPC-derived pancreatic progenitors within microporous PLG scaffolds into the epididymal fat pad, the murine surrogate for the clinically relevant omental pouch. Kidney capsule injection, the site most commonly utilized to test stem cell-derived β cell function in murine models, was the comparison condition. We observed that the microporous scaffolds supported cell engraftment, however the levels of circulating C-peptide were lower when compared to the kidney capsule condition. The scaffolds were subsequently modified to provide sustained release of exendin-4, which led to significantly increased C-peptide production. Image analysis revealed that exendin-4 releasing scaffolds enhanced the proportion of pancreatic progenitors that matured to monohormonal insulin producing cells.

Next I present my findings from studying how hPPC-derived β cells mature and function within three transplantation sites: the i) scaffold delivery into the epididymal fat pad, ii) scaffold delivery into the subcutaneous space, and iii) the kidney capsule injection (control). Additionally, we investigated the impact of blood glucose levels on maturation of the hPPC-derived β cells by transplanting mice with pre- or post-engraftment diabetes induction. Hyperglycemia was ameliorated in the cohorts of mice that received scaffolds into the epididymal fat pad, following a period of in vivo maturation. The function of these cells was demonstrated by the reduction in blood glucose levels, healthy increase in weight, therapeutic levels of circulating human insulin, and healthy responses to glucose challenge tests. The function from the epididymal fat pad was superior to the subcutaneous space and was observed to be comparable to the kidney capsule. No differences were observed in graft function between the cohorts whose grafts matured in a diabetic or non-diabetic environment, yet several differences in gene expression were observed.

Many of the current differentiation protocols culture the cells above a feeder layer in monolayer, or in suspension within a bioreactor. Typically, these protocols require the disruption of the cell niche during key differentiation stages or pre-transplantation handling. Biomaterial scaffolds maintain the integrity of cell-to-cell and cell-to-matrix connections by providing both a space for cell niche development as well as a vehicle for transplantation into the body. Herein, I present results from testing the developmental stage in which progenitors are seeded into the 3D niche, and two differentiation strategies prior to seeding: monolayer and suspension culture. Maturation was characterized via gene expression analysis, glucose stimulated insulin secretion assay, and nondestructive microscopy utilizing a sfGFP-C-peptide cell line that reports C-peptide production and secretion. We observed that seeding clusters during the key transition phase from pancreatic progenitor to pancreatic endocrine enhanced commitment to the final beta cell fate.

This work enhances our understanding of hPPC-derived beta cell manufacturing within scaffolds, and delivery to an extrahepatic site to achieve normoglycemic blood glucose levels.

Date: Wednesday, August 4, 2021
Time: 10:00 AM
Zoom: https://umich.zoom.us/j/98009467275
Password: betacell
Chair: Dr. Lonnie Shea

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Presentation Mon, 02 Aug 2021 10:58:53 -0400 2021-08-04T10:00:00-04:00 2021-08-04T11:00:00-04:00 Off Campus Location Biomedical Engineering Presentation BME Event
BME PhD Defense: Dorsa Haji Ghaffari (August 5, 2021 11:00am) https://events.umich.edu/event/84795 84795-21624995@events.umich.edu Event Begins: Thursday, August 5, 2021 11:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

Retinal prostheses have restored a sense of vision in patients blinded by photoreceptor degeneration. These electronic implants operate by electrically stimulating the remaining retinal cells. While retinal prosthesis users report improvements in light perception and performing basic visual tasks, their ability to perceive shapes and letters remains limited. Investigating stimulation strategies to reduce perceptual thresholds and create focal, non-overlapping phosphenes will increase the resolution of retinal prostheses and improve the overall patient outcomes. In this thesis I explore two main strategies for electrode-specific optimization of stimulation parameters: 1) a novel pulse paradigm for threshold reduction, and 2) an automated closed-loop method for adjusting stimulation parameters to create a focal retinal activation area.

I combined human subject testing and computational modeling to investigate the effect of waveform asymmetry on perception shapes and thresholds with epiretinal stimulation. Threshold measurement and phosphene shape analysis was performed on four Argus II users. A computational model of a retinal ganglion cell (RGC) was created in the NEURON simulation environment to allow for a more thorough parameter testing and to gain insight into the biophysical mechanisms. Our human subject results suggest that asymmetric waveforms could increase perception probabilities compared to a standard symmetric pulse, and this effect can be intensified by addition of an interphase gap (IPG). Our in silico model predicts that the most effective pulse for threshold reduction is asymmetric anodic-first stimulation with small duration ratios (≤ 5) and long IPGs (≥ 2 ms). Phosphene shape analysis revealed no significant difference in percept elongation with different pulse types. Average phosphene area was larger with asymmetric anodic-first stimulation compared to other pulse types.

Prosthetic vision quality is highly dependent on the capability to precisely activate target neurons and avoid off-target activation. However, studies show elongated and inconsistent responses to single electrode stimulation, indicating unintended stimulation of off-target neurons and electrode-specific activation patterns. While tuning stimulation parameters can transform the spatial RGC activity, a manual search for optimal parameters can be time consuming and tiring for patients. I developed a process for automatic optimization of stimulation parameters in silico, which involved training neural networks for quantifying the relationship between pulse parameters and spatial response descriptors, and a closed-loop algorithm to search for optimal parameters. Using this process, I was able to guide the parameter search effectively and converge to an optimal response within a few iterations.

Finally, I presented a process for automatic optimization of stimulation parameters in vitro using calcium imaging in mouse retina. This process involved training neural networks at each iteration based on a few images, using an interior point algorithm to find the optimal parameters, and classifying the resulting calcium images with a CNN trained on previous data. Our results indicate that we can converge to optimal stimulation parameters that create focal RGC activity by sampling less than 1/3 of the parameter space. This approach can shorten the exploration time significantly compared to a manual search, especially when the parameter space is large. Findings of this project could lead to the development of a clinically applicable system for electrode-specific optimization of stimulation protocol, improving the overall outcome of artificial vision.

Date: Thursday, August 5, 2021
Time: 11:00 AM
Zoom: https://umich.zoom.us/j/93552322970
Chair: Dr. James Weiland

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Presentation Wed, 28 Jul 2021 12:42:01 -0400 2021-08-05T11:00:00-04:00 2021-08-05T12:00:00-04:00 Off Campus Location Biomedical Engineering Presentation BME Event
BME PhD Defense: Ahmet Emre (August 9, 2021 2:00pm) https://events.umich.edu/event/84859 84859-21625204@events.umich.edu Event Begins: Monday, August 9, 2021 2:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Energy storage is an integral part of life. Living creatures have developed a distributed and structural energy storage system to survive under various and sometimes extreme conditions. Similarly, energy storage is critical for modern life to power from small biomedical instruments to large aircraft. There are still several challenges against efficient and safe energy storage utilization due to the mechanical, chemical, and physical limitations of existing materials. Inspired by biological structures, we present multifunctional nanocomposites from aramid nanofibers (ANF), a nanoscale version of Kevlar, to address the safety and efficiency of various battery chemistries and enable structural energy storage to increase energy density. High mechanical properties of ANF suppress dendrite formation, and tunability with different copolymers and fabrication methods allow ANF-based nanocomposites to meet specific needs of different battery chemistries.

In the first part of this thesis, we engineered biomimetic solid electrolyte from ANF and polyethylene oxide for zinc batteries inspired by the cartilage structure. These strong nanocomposites can block stiff zinc dendrite and prevent short circuits over cycles. Resilience to plastic deformation and damage while having no leaking fluids or cracks is essential for the safety of, for instance, electrical vehicles employing such batteries. These load-bearing batteries can be used as a structural component and increase energy density by simply avoiding inactive parts. As a proof of concept, we utilized this battery on a commercial drone as an auxiliary energy storage unit to extend flight endurance by about 20%.

The second part of the thesis addresses a specific polysulfide shuttle problem in lithium-sulfur batteries utilizing bioinspired ANF nanocomposites. Mimicking ion channels on the cell membrane, we engineered biomimetic nanochannels (1nm diameter) for selectively allowing lithium-ion passage while physically blocking lithium polysulfide species (>2nm) on the cathode side. Selective ion transport through nanochannels is also modeled by finite element analysis, COMSOL. These ion channels allow us to reach >3500 cycles.

In addition to previous solid and liquid electrolyte systems, here in the last part of the thesis, we present a tunable quasi-solid polymer electrolyte to take advantage of both electrolyte features while minimizing their individual risks and drawbacks. Similar to the kidney filtration system, specifically the glomerular basement membrane, this gel electrolyte filters ions depending on their size and charge. Selective permeability and regulated ion transport provide safe and stable charge/discharge cycles. High mechanical properties keep functionality under extreme conditions, including high temperature and nail penetration. We integrated pouch cells in various prototypes to show practical utilization of our structural batteries, including health monitoring devices, robotic prosthetics, and electric vehicles.

Taken together, mimicking structural and functional properties of multifunctional biological materials, i.e., cartilage, we present a novel multifunctional nanocomposite system that can be tailored to the specific needs of numerous structural energy storage applications.

Date: Monday, August 9, 2021
Time: 2:00 PM
Zoom: https://umich.zoom.us/j/92570283886
Chair: Prof. Nicholas Kotov

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Presentation Mon, 02 Aug 2021 12:53:44 -0400 2021-08-09T14:00:00-04:00 2021-08-09T15:00:00-04:00 Off Campus Location Biomedical Engineering Presentation BME Event
BME Master's Defense: Hind AlYahya (August 10, 2021 1:00pm) https://events.umich.edu/event/84890 84890-21625248@events.umich.edu Event Begins: Tuesday, August 10, 2021 1:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Peripheral arterial disease (PAD) is a disorder that restricts the blood flow in arteries that carry blood to the limbs; it frequently affects the legs. This restriction occurs due to severe atherosclerosis (stenosis), an accumulation of fatty materials in the vessel lumen. Stents are used to manage this disease. However, in-stent restenosis can occur at an unpredictable time, leading to emergency hospitalization or death.

The wireless magnetoelastic monitoring system showed its potential to detect restenosis. The main components of this system are a miniaturized wireless sensor integrated into the stent and a bias magnet. The purpose of using a magnet is to provide a uniform magnetic field for the sensor to operate. This work aims to improve the design of the system components to be compatible with the commercial self-expanding vascular stents. The magnetoelastic sensor was designed to fit with a conventional self-expanding stent (e.g., Innova™ from Boston Scientific Corp.) used to treat superficial femoral artery lesions. It is designed to be a single layer of MetglasTM 2826MB (12 mm x 0.85 mm x 29 um). However, the sensor could be damaged during the stent deployment. As a result, it is necessary to encapsulate the sensor. A polymeric package was designed to house the sensor and the biasing magnet. The package is attached to the stent structure by two helical wires made of nitinol material. The biasing magnet is a strip of ArnokromeTM 5 (13.2 mm x 0.85 mm x 50 um). FEA tool was used to evaluate the performance of the sensor and the magnetic strip. The results showed that the sensor vibrates at 149 kHz. The magnetic field distribution confirmed that the ArnokromeTM 5 generates a sufficient magnetic field strength for the sensor to operate. This work also covers an analytical analysis of using electromagnetic coils to provide DC bias for the system. However, the results showed that the heat dissipated from the coils could be hard to manage.

If implanting this package is successful *in vivo* experiments, the detection of restenosis will be achieved in an earlier stage, saving the patient from undergoing another surgery. Therefore, the wireless monitoring system can reduce emergency surgeries and mortality that results from PAD, leading to healthier patients and a lower burden on hospital resources.

Date: Tuesday, August 10, 2021
Time: 1:00 PM
Zoom: https://umich.zoom.us/j/99281419966
Chair: Prof. Yogesh B. Gianchandani

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Presentation Tue, 03 Aug 2021 10:09:05 -0400 2021-08-10T13:00:00-04:00 2021-08-10T14:00:00-04:00 Off Campus Location Biomedical Engineering Presentation BME Event
Medical Illustration: Finding my niche in science with Dr. Jeff Day (August 20, 2021 11:00am) https://events.umich.edu/event/84938 84938-21625387@events.umich.edu Event Begins: Friday, August 20, 2021 11:00am
Location: Off Campus Location
Organized By: American Chemical Society Polymer Division – Student Chapter (ACS POLY/PMSE)

What is medical illustration and what does it have to do with you? Come learn about this tiny specialty that employs only a couple thousand people across our entire continent with Johns Hopkins medical illustrator Jeff Day. He will overview the field, share his personal career path, his professional interests and what he is looking to explore next. Along the way, Jeff will sprinkle his thoughts on searching for and finding his niche in science, and share communication lessons from medical illustration that can help with any field.

Please RSVP here: https://forms.gle/bSTCEADEv2LuvxYB6

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Workshop / Seminar Thu, 05 Aug 2021 09:26:28 -0400 2021-08-20T11:00:00-04:00 2021-08-20T12:00:00-04:00 Off Campus Location American Chemical Society Polymer Division – Student Chapter (ACS POLY/PMSE) Workshop / Seminar Poster
Artscapade! (August 28, 2021 6:00pm) https://events.umich.edu/event/84810 84810-21625050@events.umich.edu Event Begins: Saturday, August 28, 2021 6:00pm
Location: Museum of Art
Organized By: University of Michigan Museum of Art (UMMA)

.

UMMA and Arts at Michigan celebrate Welcome Week by introducing new University of Michigan students to the Museum of Art for an evening of  live music, performances, dance, poetry, film, games, prize raffle, and a variety of art-making activities.  During the event, students will  have the opportunity to become familiar with the Museum and everything it has to offer, as well as experience the wide array of possibilities for arts participation across campus. 

All students, faculty and staff on the Ann Arbor (including Michigan Medicine), Dearborn and Flint campuses are required to be vaccinated against COVID-19 and submit their vaccination information by August 30. In addition, masks will be required in all indoor spaces and social distancing guidelines will be in place.

Student programming at UMMA is generously supported by the University of Michigan Credit Union Arts Adventures Program, UMMA's Lead Sponsor for Student and Family Engagement.

 

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Presentation Sun, 29 Aug 2021 00:15:49 -0400 2021-08-28T18:00:00-04:00 2021-08-28T21:00:00-04:00 Museum of Art University of Michigan Museum of Art (UMMA) Presentation Museum of Art
U-M Food Drive for Food Gatherers (September 1, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631588@events.umich.edu Event Begins: Wednesday, September 1, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-01T08:00:00-04:00 2021-09-01T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
U-M Food Drive for Food Gatherers (September 2, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631589@events.umich.edu Event Begins: Thursday, September 2, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-02T08:00:00-04:00 2021-09-02T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
U-M Food Drive for Food Gatherers (September 3, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631590@events.umich.edu Event Begins: Friday, September 3, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-03T08:00:00-04:00 2021-09-03T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
U-M Food Drive for Food Gatherers (September 4, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631591@events.umich.edu Event Begins: Saturday, September 4, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-04T08:00:00-04:00 2021-09-04T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
U-M Food Drive for Food Gatherers (September 5, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631592@events.umich.edu Event Begins: Sunday, September 5, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-05T08:00:00-04:00 2021-09-05T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
U-M Food Drive for Food Gatherers (September 6, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631593@events.umich.edu Event Begins: Monday, September 6, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-06T08:00:00-04:00 2021-09-06T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
U-M Food Drive for Food Gatherers (September 7, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631594@events.umich.edu Event Begins: Tuesday, September 7, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-07T08:00:00-04:00 2021-09-07T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
Building Connections & Meaningful Relationships (September 7, 2021 1:00pm) https://events.umich.edu/event/86290 86290-21634311@events.umich.edu Event Begins: Tuesday, September 7, 2021 1:00pm
Location:
Organized By: Michigan Medicine Wellness Office

Starting a new school year can be tough, and one of the most important pieces of well-being and academic success require meaningful relationships.

Please register to attend! https://sessions.studentlife.umich.edu/track/event/session/45582

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Well-being Tue, 07 Sep 2021 13:53:29 -0400 2021-09-07T13:00:00-04:00 2021-09-07T14:00:00-04:00 Michigan Medicine Wellness Office Well-being Wellness Office Logo
U-M Food Drive for Food Gatherers (September 8, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631595@events.umich.edu Event Begins: Wednesday, September 8, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-08T08:00:00-04:00 2021-09-08T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
Department of Computational Medicine & Bioinformatics || Weekly Seminar Series (September 8, 2021 4:00pm) https://events.umich.edu/event/86237 86237-21632210@events.umich.edu Event Begins: Wednesday, September 8, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

Structural variants (SVs) are a source of pathogenic variants in a clinical referral population, however, they are often under-reported due to technical limitations of detection and difficulty with clinical interpretation. For example, mobile element insertions (MEIs) are estimated to lead to a positive finding in 1 out of 1000 rare genetic disease cases, yet the numbers are far lower in clinical diagnostic laboratories. Targeted NGS with short insert size libraries, unlike genome sequencing, will have very few discordant read pairs to indicate the presence of an SV. We, therefore, developed an SV detection tool called SCRAMble (Soft Clipped Read Alignment Mapper) to identify SV breakpoints in targeted NGS.

We applied SCRAMble to a prospective clinical referral cohort for exome sequencing to identify deletions and MEIs. We also applied SCRAMble to a hereditary cancer panel assay for the identification of a large inversion involving the MSH2 gene that causes Lynch syndrome. Adding breakpoint detection to clinical targeted sequencing identifies positive findings which were missed by prior testing and by other variant callers. Detecting breakpoints allows for more precise interpretation and for more targeted confirmation assays. By applying SV breakpoint detection, we are able to diagnose ~0.3% more cases. While this is a modest gain in diagnostic yield, for the patients and families involved, a positive diagnosis, even after prior testing, can have a meaningful impact on their lives.

Zoom link: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Thu, 02 Sep 2021 14:28:18 -0400 2021-09-08T16:00:00-04:00 2021-09-08T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual Rebecca Torene, Associate Director of Genomics Research | Data Science at GeneDx
Building Connections & Meaningful Relationships (September 8, 2021 6:00pm) https://events.umich.edu/event/86290 86290-21632591@events.umich.edu Event Begins: Wednesday, September 8, 2021 6:00pm
Location: Off Campus Location
Organized By: Michigan Medicine Wellness Office

Starting a new school year can be tough, and one of the most important pieces of well-being and academic success require meaningful relationships.

Please register to attend! https://sessions.studentlife.umich.edu/track/event/session/45582

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Well-being Tue, 07 Sep 2021 13:53:29 -0400 2021-09-08T18:00:00-04:00 2021-09-08T19:00:00-04:00 Off Campus Location Michigan Medicine Wellness Office Well-being Wellness Office Logo
U-M Food Drive for Food Gatherers (September 9, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631596@events.umich.edu Event Begins: Thursday, September 9, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-09T08:00:00-04:00 2021-09-09T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
U-M Food Drive for Food Gatherers (September 10, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631597@events.umich.edu Event Begins: Friday, September 10, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-10T08:00:00-04:00 2021-09-10T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
Lecture: Bon Ku, Thomas Jefferson University Health Design Lab (September 10, 2021 12:00pm) https://events.umich.edu/event/85866 85866-21629404@events.umich.edu Event Begins: Friday, September 10, 2021 12:00pm
Location:
Organized By: A. Alfred Taubman College of Architecture + Urban Planning

Bon Ku is the Director of the Health Design Lab at Thomas Jefferson University where he created the first design thinking program at a medical school. He is the Marta and Robert Adelson Professor of Medicine and Design, the Associate Dean for Health & Design and a practicing emergency physician. His work toward redesigning healthcare has been featured in The New York Times, CNBC, Architectural Digest and Fast Company. Dr. Ku has spoken at conferences, academic medical centers and universities around the world: SXSW, TEDx, Yale School of Management, American Institute of Architects and Singapore Design Week. Dr. Ku is the host of the Design Lab Podcast, co-wrote the book, Health Design Thinking, with Ellen Lupton and was a regular panelist on the primetime medical TV show Chasing the Cure with Ann Curry.

This event will be held in-person at the Art & Architecture Building (2000 Bonisteel Blvd., Ann Arbor, MI), room 1360, and will also be live-streamed. Please register for the event to attend or to receive the link for the virtual streaming: https://umich.formstack.com/forms/bon_ku

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Lecture / Discussion Wed, 01 Sep 2021 09:59:47 -0400 2021-09-10T12:00:00-04:00 2021-09-10T13:00:00-04:00 A. Alfred Taubman College of Architecture + Urban Planning Lecture / Discussion Health Design Diagram
Human Genetics Annual Retreat - Keynote Seminar (September 10, 2021 2:00pm) https://events.umich.edu/event/86250 86250-21632243@events.umich.edu Event Begins: Friday, September 10, 2021 2:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Department of Human Genetics

FRIDAY, SEPTEMBER 10
2:00 PM – 3:00 PM EST
BSRB KAHN AUDITORIUM
109 ZINA PITCHER PL, ANN ARBOR

HOSTED BY:
Jacob Mueller, Ph.D.
Associate Professor of Human Genetics
Associate Professor of Obstetrics and Gynecology
Associate Professor of Urology
University of Michigan

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Lecture / Discussion Thu, 02 Sep 2021 16:36:15 -0400 2021-09-10T14:00:00-04:00 2021-09-10T15:00:00-04:00 Taubman Biomedical Science Research Building Department of Human Genetics Lecture / Discussion DHG RETREAT 2021_Keynote Speaker Flyer
U-M Food Drive for Food Gatherers (September 11, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631598@events.umich.edu Event Begins: Saturday, September 11, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-11T08:00:00-04:00 2021-09-11T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
U-M Food Drive for Food Gatherers (September 12, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631599@events.umich.edu Event Begins: Sunday, September 12, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-12T08:00:00-04:00 2021-09-12T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
U-M Food Drive for Food Gatherers (September 13, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631600@events.umich.edu Event Begins: Monday, September 13, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-13T08:00:00-04:00 2021-09-13T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
How Safe Is Safe Enough: Analyzing Hazards and Risks in the Real World to Inform Decision Making (September 13, 2021 4:30pm) https://events.umich.edu/event/86451 86451-21634340@events.umich.edu Event Begins: Monday, September 13, 2021 4:30pm
Location: Industrial and Operations Engineering Building
Organized By: Center for Healthcare Engineering & Patient Safety (CHEPS)

No endeavor/decision is without risk. Despite the best of intentions decisions that lead to undesired outcomes (financial, human, political, reputation), many times catastrophic, occur during the operation of complex systems. Unfortunately (tragically), it is also common that the parties that made these decisions or were impacted by these undesired outcomes viewed them as unexpected when they occurred. Even worse, because the outcomes were unexpected there was generally little or no preparation for their occurrence further magnifying the extent and the impact to the individuals, organizations, and society as a whole. Since no system can be reasonably expected to perform flawlessly and with perfection all of the time, the hazards that can cause undesired outcomes should be proactively identified and their associated risks should be either mitigated or the residual risk after mitigation should be accepted by those entities responsible for the system in question. Unfortunately, history shows us that this is often not the case and arises from myriad reasons. Engineering risk analysis provides a systematic, holistic approach for addressing risks associated with complex technical systems. The irony is that few engineers are ever introduced to or learn how to apply this knowledge in their professional activities. A discussion of approaches, including real world examples, to proactively identify hazards, their associated risks, and potential mitigation approaches that can mitigate the likelihood that an unacceptable outcome will occur.

Dr. James P. Bagian is a co-founder and the Executive Director of the Center for Risk Analysis Informed Decision Engineering (RAIDE) and is a Professor in the Departments of Industrial and Operations Engineering, Aerospace Engineering, and the Department of Anesthesiology at the University of Michigan. He has extensive experience in the fields of human factors, aviation, patient and transportation safety, and risk assessment and management. Dr. Bagian was also the founding Director of the Center for Healthcare Engineering and Patient Safety at the University of Michigan. Previously he served as the first and founding director of the Department of Veterans Affairs National (VA) Center for Patient Safety and was the VA’s first Chief Patient Safety Officer where he developed numerous systems and risk based tools and programs that have been adopted nationally and internationally. A NASA astronaut, he is a veteran of two Space Shuttle missions and has also served as the Chief Flight Surgeon and Medical Consultant for the Space Shuttle Columbia Accident Investigation Board as well as being an investigator for the Space Shuttle Challenger mishap investigation. He was elected to two terms as the Chair of the Joint Commission’s Patient Safety Advisory Group and was a member of NASA’s Aerospace Safety Advisory Panel from 2006-2018. Bagian holds a B.S. degree in mechanical engineering from Drexel University and a doctorate in medicine from Thomas Jefferson University. He is a Fellow of the Aerospace Medical Association and is an elected member of the National Academy of Engineering and the National Academy of Medicine.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach. For the Zoom link and password and to be added to the weekly e-mail for the series, please RSVP. For additional questions, contact CHEPSseminar@umich.edu. Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Tue, 07 Sep 2021 16:17:10 -0400 2021-09-13T16:30:00-04:00 2021-09-13T17:30:00-04:00 Industrial and Operations Engineering Building Center for Healthcare Engineering & Patient Safety (CHEPS) Lecture / Discussion James P. Bagian, MD, PE
Please join us for an evening conversation between Emma Green and Charlie Camosy on Dr. Camosy's new book Losing Our Dignity: How Secularized Medicine is Undermining Fundamental Human Equality. (September 13, 2021 7:00pm) https://events.umich.edu/event/84807 84807-21625037@events.umich.edu Event Begins: Monday, September 13, 2021 7:00pm
Location: Off Campus Location
Organized By: The University of Michigan Medical School Program on Health, Spirituality and Religion

Emma Green - Staff Writer at The Atlantic

AND

Charles Camosy, PhD
Associate Professor of Theology, Fordham University

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Workshop / Seminar Thu, 29 Jul 2021 10:28:46 -0400 2021-09-13T19:00:00-04:00 2021-09-13T20:00:00-04:00 Off Campus Location The University of Michigan Medical School Program on Health, Spirituality and Religion Workshop / Seminar
U-M Food Drive for Food Gatherers (September 14, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631601@events.umich.edu Event Begins: Tuesday, September 14, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-14T08:00:00-04:00 2021-09-14T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
U-M Food Drive for Food Gatherers (September 15, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631602@events.umich.edu Event Begins: Wednesday, September 15, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-15T08:00:00-04:00 2021-09-15T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
Department of Computational Medicine & Bioinformatics Weekly Seminar Series (September 15, 2021 4:00pm) https://events.umich.edu/event/86598 86598-21635116@events.umich.edu Event Begins: Wednesday, September 15, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

Chromosomal instability (CIN) results in the accumulation of large-scale losses, gains, and rearrangements of DNA. The broad genomic complexity caused by CIN is a hallmark of cancer, however, there is no systematic framework to measure different types of CIN and their impact on clinical phenotypes. Here, we evaluate the extent, diversity and origin of chromosomal instability across 7,880 tumors representing 33 cancer types from the TCGA collection. We present a compendium of 17 copy number signatures characterizing specific types of CIN, with putative aetiologies supported by multiple independent data sources. The signatures predict drug response and identify new drug targets. Our framework refines the understanding of impaired homologous recombination, one of the most therapeutically targetable types of CIN. Our results illuminate a fundamental structure underlying genomic complexity and provide a resource to guide future CIN
research in human cancers.

Bio:

Florian Markowetz is a Senior Group Leader at the Cancer Research UK Cambridge Institute. He is a Royal Society Wolfson Research Merit Award holder and received a CRUK Future Leader in Cancer Research prize. He holds degrees in Mathematics (Dipl. math.) and Philosophy (M.A.) from the University of Heidelberg and a Dr. rer. nat. (PhD equivalent) in Computational Biology from Free University Berlin, for which he was awarded an Otto-Hahn Medal by the Max Planck Society. His group at the CRUK Cambridge Institute combines computational work on cancer evolution and image analysis of the tumor tissue with experimental work on understanding key cancer mechanisms like the estrogen receptor.

Zoom link: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Thu, 09 Sep 2021 11:24:05 -0400 2021-09-15T16:00:00-04:00 2021-09-15T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual Florian Markowetz (Senior Group Leader at the Cancer Research UK Cambridge Institute)
"The History of Anatomy - From Alcmaeon to Skandalakis" (HYBRID EVENT) (September 15, 2021 6:30pm) https://events.umich.edu/event/86488 86488-21634731@events.umich.edu Event Begins: Wednesday, September 15, 2021 6:30pm
Location: Off Campus Location
Organized By: The Society for the History and Philosophy of Medicine

**HYBRID EVENT** View details below with RSVP required at event in person.

Title: The History of Anatomy - From Alcmaeon to Skandalakis
by Dr. Christian Vercler

The Plastic Surgery Student Interest Group (PSIG) and the Society for the History and Philosophy of Medicine, are joining together to host an in person and virtual hybrid event titled "The History of Anatomy - From Alcmaeon to Skandalakis" on Wednesday September 15th, 2021 from 6:30-7:30 pm, which will be facilitated by Dr. Christian Vercler. Snacks will be provided for those joining us in person. Please RSVP using the link below and also let us know if you are interested in joining our email lists.
When: Wednesday September 15th, 2021 from 6:30-7:30 pm
Where: MED Sci I, M3330 (hallway that connects med school and the hospital) or by Zoom; snacks will be provided
RSVP: https://forms.gle/WDpdQ8848UnXmS4Y7

Zoom link: https://umich.zoom.us/j/93796864104
Meeting ID: 937 9686 4104
Passcode: 223856

Go Blue,
Plastic Surgery Student Interest Group and the Society for the History and Philosophy of Medicine

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Other Wed, 08 Sep 2021 12:14:36 -0400 2021-09-15T18:30:00-04:00 2021-09-15T19:30:00-04:00 Off Campus Location The Society for the History and Philosophy of Medicine Other
U-M Food Drive for Food Gatherers (September 16, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631603@events.umich.edu Event Begins: Thursday, September 16, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-16T08:00:00-04:00 2021-09-16T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
Bringing Equity to the Forefront in Global Health (September 16, 2021 12:00pm) https://events.umich.edu/event/86029 86029-21631135@events.umich.edu Event Begins: Thursday, September 16, 2021 12:00pm
Location: Off Campus Location
Organized By: Center for Global Health Equity

What do we mean by ‘equity’ in global health? Where and how can academic institutions redefine their roles in advancing global health equity? Join us for a virtual conversation about new approaches and perspectives from communities who are directly impacted by this work. Featuring Ethiopia Minister of Health Lia Tadesse Gebremedhin, and Abebe Bekele, Dean of the School of Medicine at the University of Global Health, Rwanda.

Center Director Joseph C. Kolars and Clinical Assistant Professor of Epidemiology Ella August will facilitate the discussion with our esteemed international colleagues.

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Livestream / Virtual Tue, 31 Aug 2021 11:26:58 -0400 2021-09-16T12:00:00-04:00 2021-09-16T13:30:00-04:00 Off Campus Location Center for Global Health Equity Livestream / Virtual Featured Speakers
BME 500 Seminar: Nicholas A. Graham, Ph.D. (September 16, 2021 4:00pm) https://events.umich.edu/event/87034 87034-21638155@events.umich.edu Event Begins: Thursday, September 16, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Nicholas A. Graham, Ph.D.
Mork Family Department of Chemical Engineering and Materials Science,
University of Southern California

“Systems biology approaches to drug discovery for cancer and aging”

Abstract:

“Omics” technologies have enabled network-level measurements of genes, proteins, and metabolites from cellular models of disease. Systems biology attempts to synthesize these quantitative measurements into data-driven models to explain biological function and identify targeted therapeutic drugs. Here, I will discuss three different engineering systems biology approaches using metabolomics, proteomics, and bioinformatics to identify or discover drugs for cancer and aging. First, using metabolomics, we designed a synergistic drug combination that mimics nutrient deprivation to kill cancer cells. Second, by integrating a proteomic signature of cellular senescence with large-scale drug screening databases, we predicted and then validated that EGFR inhibitors are toxic to a model of cellular aging, specifically senescent human mammary epithelial cells. Finally, we developed a bioinformatic approach to integrate gene expression data with drug screening data from hundreds of cancer cell lines to identify clinically approved drugs whose efficacy depends on metabolic pathway activity. Taken together, these studies demonstrate how metabolomics, proteomics, and bioinformatics can all serve to identify drugs for cancer and aging.

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Lecture / Discussion Wed, 15 Sep 2021 15:08:08 -0400 2021-09-16T16:00:00-04:00 2021-09-16T17:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Event
U-M Food Drive for Food Gatherers (September 17, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631604@events.umich.edu Event Begins: Friday, September 17, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-17T08:00:00-04:00 2021-09-17T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
Opportunity Kick-Off: Preparing a Competitive NIH S10 Instrumentation Proposal (September 17, 2021 12:00pm) https://events.umich.edu/event/85468 85468-21626488@events.umich.edu Event Begins: Friday, September 17, 2021 12:00pm
Location: Off Campus Location
Organized By: OVPR Office of Research Development

Hosted by U-M Research Development and the Biosciences Initiative, this webinar will provide an overview of NIH S10 Instrumentation Grants, including U-M success rates, common reviewer critiques, a timeline for developing a strong proposal, and resources to support your efforts.
Recent S10 awardees will join our panel to discuss their experiences, offer tips for success and answer your questions.

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Workshop / Seminar Thu, 19 Aug 2021 16:59:13 -0400 2021-09-17T12:00:00-04:00 2021-09-17T13:00:00-04:00 Off Campus Location OVPR Office of Research Development Workshop / Seminar Closeup of microscope
U-M Food Drive for Food Gatherers (September 18, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631605@events.umich.edu Event Begins: Saturday, September 18, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-18T08:00:00-04:00 2021-09-18T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
U-M Food Drive for Food Gatherers (September 19, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631606@events.umich.edu Event Begins: Sunday, September 19, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-19T08:00:00-04:00 2021-09-19T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
U-M Food Drive for Food Gatherers (September 20, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631607@events.umich.edu Event Begins: Monday, September 20, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-20T08:00:00-04:00 2021-09-20T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
Machine Learning and Causality: Building Efficient, Reliable Models for Decision-Making (September 20, 2021 4:30pm) https://events.umich.edu/event/86942 86942-21637609@events.umich.edu Event Begins: Monday, September 20, 2021 4:30pm
Location: Industrial and Operations Engineering Building
Organized By: Center for Healthcare Engineering & Patient Safety (CHEPS)

Increasingly practitioners are looking to ML-based causal and predictive models to provide personalized decision guidance. However, current techniques for causal inference typically rely on having access to large amounts of data, limiting their applicability to data-constrained settings such as healthcare where collection of data might be prohibitively costly. In addition, empirical evidence has shown that most predictive models are insufficiently robust with respect to shifts at test time. This talk presents novel techniques addressing both of these problems.

Much of the causal literature focuses on learning accurate individual treatment effects, which can be complex and hard to estimate from small samples. However, it is often sufficient for clinicians to have estimates of upper and lower bounds on the potential outcomes of decision alternatives to assess risks and benefits. I will show that in such cases we can improve sample efficiency by estimating simple functions that bound these outcomes instead of estimating their conditional expectations. I will present a novel algorithm that leverages these theoretical insights.

I will also present approaches to deal with distribution shifts. I will discuss how distribution shift arises when training models to predict contagious infections in the presence of asymptomatic carriers. I will present a causally-motivated regularization scheme that enables prediction of the true infection state with high accuracy even if the training data is collected under biased test administration.

Maggie Makar is the Presidential postdoctoral fellow at the University of Michigan, and a visiting research at Microsoft Research. Dr. Makar recieved her PhD in Computer Science at MIT. While at MIT, Maggie interned at Microsoft Research, and Google Brain. Prior to MIT, Maggie worked at Brigham and Women’s Hospital, studying end-of-life care. Her work has appeared in ICML, AAAI, JSM, the Journal of the American Medical Association (JAMA), Health Affairs, and Epidemiology among others. Maggie received a B.Sc. in Math and Economics from the University of Massachusetts, Amherst.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach. For the Zoom link and password and to be added to the weekly e-mail for the series, please RSVP. For additional questions, contact CHEPSseminar@umich.edu. Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Mon, 20 Sep 2021 13:25:21 -0400 2021-09-20T16:30:00-04:00 2021-09-20T17:30:00-04:00 Industrial and Operations Engineering Building Center for Healthcare Engineering & Patient Safety (CHEPS) Lecture / Discussion Maggie Makar, Ph.D.
U-M Food Drive for Food Gatherers (September 21, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631608@events.umich.edu Event Begins: Tuesday, September 21, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-21T08:00:00-04:00 2021-09-21T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
The Futurescape of Medicine Lecture Series (September 21, 2021 10:00am) https://events.umich.edu/event/85070 85070-21625544@events.umich.edu Event Begins: Tuesday, September 21, 2021 10:00am
Location: Off Campus Location
Organized By: Osher Lifelong Learning Institute (50+)

The goal of this lecture series is to provide educational insights about future developments in five different areas of medical care.

Lecture #1 is Healthcare Financing - A Broken System in need of Repair. The speaker is Mark Frederick, MD.

Attention will be paid to current best practices, ethical implications of new technologies, promotion of consumer education and choices, and financial aspects of delivery in the context of value-based care. A lively discussion is anticipated for each lecture regarding the many issues raised by these trends and technologies.”

The series will take place every other Tuesday from 10-11:30 starting September 21. 2021, and ending November 16.

Preregistration is required via the OLLI website or phone. A link to access the lecture will be e-mailed prior to the event.

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Class / Instruction Tue, 10 Aug 2021 12:14:45 -0400 2021-09-21T10:00:00-04:00 2021-09-21T11:30:00-04:00 Off Campus Location Osher Lifelong Learning Institute (50+) Class / Instruction Futurescape of Medicine
U-M Food Drive for Food Gatherers (September 22, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631609@events.umich.edu Event Begins: Wednesday, September 22, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-22T08:00:00-04:00 2021-09-22T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
Department of Computational Medicine & Bioinformatics Weekly Seminar (September 22, 2021 4:00pm) https://events.umich.edu/event/87282 87282-21640718@events.umich.edu Event Begins: Wednesday, September 22, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

Histones are small proteins that package DNA into chromosomes, and a large number of studies have showed that several post-translational modification (PTM) sites on the histones are associated with both gene activation and silencing. Along with DNA and small non-coding RNA, histone PTMs make up epigenetic mechanisms that control gene expression patterns outside of DNA sequence mutations. Dysregulation of these chromatin networks underlie several human diseases such as cancer. Here I will give an update on technology advancements that have allowed for high-throughput quantitative analyses of histone PTMs and chromatin structure, and how we are applying these methods to understand epigenetic reprogramming found in malignant peripheral nerve sheath tumors (MPNSTs). MPNST is an aggressive sarcoma with recurrent loss of function alterations in polycomb-repressive complex 2 (PRC2), a histone-modifying complex involved in transcriptional silencing.

Zoom Link: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Mon, 20 Sep 2021 15:27:41 -0400 2021-09-22T16:00:00-04:00 2021-09-22T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual
Time Management Strategies (September 22, 2021 6:00pm) https://events.umich.edu/event/86295 86295-21632603@events.umich.edu Event Begins: Wednesday, September 22, 2021 6:00pm
Location: Off Campus Location
Organized By: Michigan Medicine Wellness Office

Are there never enough hours in the day? Learn tools, tips, and strategies to improve your time management skills. We will discuss how time management is related to stress management and how to get more control over your schedule. This session will introduce some new skills and ideas to better prioritize what needs to get done while still taking care of yourself and feeling good about your day.

Please register for zoom details
https://sessions.studentlife.umich.edu/track/event/session/45693

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Well-being Fri, 03 Sep 2021 11:30:34 -0400 2021-09-22T18:00:00-04:00 2021-09-22T19:00:00-04:00 Off Campus Location Michigan Medicine Wellness Office Well-being Wellness Office Logo
U-M Food Drive for Food Gatherers (September 23, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631610@events.umich.edu Event Begins: Thursday, September 23, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-23T08:00:00-04:00 2021-09-23T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
DCM&B Tools and Technology Seminar (September 23, 2021 12:00pm) https://events.umich.edu/event/85310 85310-21626212@events.umich.edu Event Begins: Thursday, September 23, 2021 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

This presentation will be given remotely, with the livestream available for group viewing in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

URL for remote viewing: https://umich-health.zoom.us/j/94886745590?pwd=LzhLU243K2ZhbXNzU1BJRHQ5V25BZz09

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Presentation Wed, 18 Aug 2021 09:24:07 -0400 2021-09-23T12:00:00-04:00 2021-09-23T13:00:00-04:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
Holocaust and Medicine Education for Resilient Professional Identity Formation: A Holocaust Survivor's Daughter Teaches German Medical Students at Auschwitz (September 23, 2021 12:00pm) https://events.umich.edu/event/85430 85430-21626417@events.umich.edu Event Begins: Thursday, September 23, 2021 12:00pm
Location: Off Campus Location
Organized By: The University of Michigan Medical School Program on Health, Spirituality and Religion

Dr. Hedy Wald is Clinical Professor of Family Medicine at the Alpert Medical School of Brown University and Faculty, Harvard Medical School Pediatrics Leadership Program. She is a Gold Humanism Foundation Harvard Macy Scholar, was a Fulbright Specialist Scholar in medical education for Ben Gurion University of Health Sciences, Israel, and has been a Visiting Professor at over 90 healthcare professions schools and healthcare organizations world-wide, presenting lectures and workshops on using interactive (guided) reflective writing to enhance reflective practice and support professional identity formation, promoting resilience and wellbeing, and Holocaust and Medicine in health professions education. Dr. Wald holds an appointment as a Commissioner for the international Lancet Commission on Medicine and the Holocaust.  She publishes and presents on family cancer caregiver survivorship, including for the National Cancer Policy Forum of the National Academies of Medicine in Washington, DC. Her creative writing, reviews, and poetry have appeared in literary and medical journals and her work has been cited in the Wall Street Journal, New York Times, LA Times, Chicago Tribune, Medical Independent (Ireland), and Jerusalem Post. Dr. Wald has been cited on Twitter as a medical educator to follow, on #WomeninMedicine Day as a “woman who lifts others up,” and “a voice of conscience and compassion.” Follow her on Twitter: @hedy_wald “Mind/Body/Spirit of MedEd”

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Workshop / Seminar Thu, 19 Aug 2021 08:47:58 -0400 2021-09-23T12:00:00-04:00 2021-09-23T13:00:00-04:00 Off Campus Location The University of Michigan Medical School Program on Health, Spirituality and Religion Workshop / Seminar
Alum Connection: Board Certified Plastic Surgeon, Dr. Stephen Madry (September 23, 2021 1:00pm) https://events.umich.edu/event/86918 86918-21637564@events.umich.edu Event Begins: Thursday, September 23, 2021 1:00pm
Location: Off Campus Location
Organized By: LSA Opportunity Hub

Join U-M alum Dr. Stephen Madry for a conversation designed to explore the fast-paced, high-demand world of plastic surgery. Dr. Madry will share his own professional journey, and his advice for students considering a career in health and medicine. Bring your questions about applying to medical school, determining your specialization, and building a successful career around helping people feel their best.

About Dr. Madry:
Stephen Madry, MD is a board-certified plastic surgeon in Barrington, IL just outside of Chicago. For over three decades, patients have traveled to his clinic from around the country because of Dr. Madry’s results and outstanding reputation for helping people feel their best.
Dr. Madry received his MD degree from Michigan State University in June 1989. Prior to that, he earned both his MPH degree in Epidemiology and BS in Pharmacology from the University of Michigan.
His residencies were completed at Wayne State University (General Surgery) and Loyola University (Plastic Surgery). Dr. Madry is an Associate Fellow of the American College of Surgeons and a Member of the American Society of Plastic Surgery.

You should attend this session if you are:
-A UM undergraduate LSA student interested in pursuing a career in medicine
-Interested in learning more about the medical school experience, and how you might identify your specialization
-Exploring your options for experiential learning related to careers in health and medicine

What you’ll gain by attending:
-Get advice from a U-M alum about life as a plastic surgeon
-Get helpful anecdotes and advice on preparing for and applying to medical school
-Gain access to an experienced professional who can become part of your active network

Interaction: Moderate

RSVP now to be part of the conversation. The link to join this Alum Connection will be emailed to you after you RSVP.

The LSA Opportunity Hub aims to deliver inclusive and accessible experiences and welcomes all LSA students to participate. This event will be hosted on Zoom (learn more about Zoom accessibility) and can be accessed by phone or computer. Presentation materials may be shared in advance if requested, and live captioning will be provided. To request other accommodations please contact Paige Baker at paigebak@umich.edu or 734.763.4674. so we can make arrangements.

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Workshop / Seminar Thu, 16 Sep 2021 12:04:33 -0400 2021-09-23T13:00:00-04:00 2021-09-23T14:00:00-04:00 Off Campus Location LSA Opportunity Hub Workshop / Seminar LSA Students
EIHS Symposium: Health, the Body Politic, and the Language of Recovery (September 23, 2021 4:00pm) https://events.umich.edu/event/85449 85449-21626468@events.umich.edu Event Begins: Thursday, September 23, 2021 4:00pm
Location: Tisch Hall
Organized By: Eisenberg Institute for Historical Studies

This is a hybrid event. Link here for in-person registration (limited): https://myumi.ch/yKo1N
Link here to stream via Zoom: https://myumi.ch/1p3oO

Description: We think it fitting to inaugurate our year-long theme, "Recovery," with a roundtable discussion on the language of recovery in health and medicine. It is in this context that recovery, both physical and mental, has been the focus of some of the oldest and most sustained attention and, increasingly now, critique. While recovery has still proven notoriously difficult to define, measure, and implement, with its champions and critics alike highlighting the lack of consensus on what exactly constitutes recovery, the term has at least since the 1990s come to dominate certain health sectors. This dominance is most notable in mental health policy. Within the critical medical humanities, it has become clear that the discourse of recovery is entangled in complex relations of power without being entirely fixed by them. Can recovery, despite its discontents, still have radical political potential? Is recovery itself in need of being recovered? What are the stakes in this contested sector of the body politic? Our panelists, as they explore the stakes of “recovery” from within their respective fields, will help us launch our critical engagement with recovery both as rhetoric and practice.

Panelists:
• Henry M. Cowles (Associate Professor, History, University of Michigan)
• Yi-Li Wu (Associate Professor; History, Women's and Gender Studies; University of Michigan)
• M. Remi Yergeau (Associate Professor; English Language and Literature, University of Michigan)
• Rachel Rafael Neis (moderator; Jean and Samuel Frankel Associate Professor; History, Judaic Studies; University of Michigan)

This event presented by the Eisenberg Institute for Historical Studies. It is made possible in part by a generous contribution from Kenneth and Frances Aftel Eisenberg.

Image: "Abstract," Dany Sternfeld (CC BY-NC-ND 2.0).

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Conference / Symposium Wed, 22 Sep 2021 16:20:56 -0400 2021-09-23T16:00:00-04:00 2021-09-23T18:00:00-04:00 Tisch Hall Eisenberg Institute for Historical Studies Conference / Symposium "Abstract," Dany Sternfeld (CC BY-NC-ND 2.0).
U-M Food Drive for Food Gatherers (September 24, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631611@events.umich.edu Event Begins: Friday, September 24, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-24T08:00:00-04:00 2021-09-24T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
Picture a Scientist (September 24, 2021 12:00pm) https://events.umich.edu/event/86730 86730-21639091@events.umich.edu Event Begins: Friday, September 24, 2021 12:00pm
Location: Off Campus Location
Organized By: Biostatistics

Please join us virtually on Friday, September 24th to watch and discuss the film, Picture a Scientist! This groundbreaking documentary chronicles the lives of three women scientists, who share their own experiences with sexual harassment and discrimination in order to create a more equitable and welcoming field. Watch the movie any time through this link, or join us for an online watch party at 9:30am. Then tune in at noon, to listen to a student-moderated discussion by our distinguished panel members, Dr. Patricia Coleman-Burns, Heather Colohan, Dr. Reshma Jagsi and Dr. Anna Kirkland. This will be followed by breakout room discussions (same registration as for the panel discussion) at 1:05 pm for students, staff, faculty and mixed groups.
https://sph.umich.edu/biostat/biostat_dei/biostat_dei_events/index.html

PANEL DISCUSSION (12 - 1PM ET)

Patricia W. Coleman-Burns, PhD, MA, U-M University of Michigan assistant professor emerita of nursing and Black studies. In addition to co-chairing the UM Academic Women's Caucus and serving on the U-M Women of Color in the Academy Project Steering Committee, she has served on the board of Safehouse Center on domestic violence and sexual assault. Her research, including her GENESIS pipeline project and EPIC Feedback Model, focuses on Black racial identity, workforce diversity, and reducing health disparities.

Heather Colohan, LMSW, U-M Sexual Assault Prevention and Awareness Center (SAPAC) Educator and Program Manager for Community Outreach & Systems Advocacy. She provides support and educational workshops to students, staff and faculty affected by sexual assault. She also supervises Raise the Bar; a program that works with local bars and transportation services to provide tailored workshops on sexual assault and bystander intervention.

Reshma Jagsi, MD, DPhil, Michigan Medicine Deputy Chair of Radiation Oncology, Newman Family Professor of Radiation Oncology, Residency Program Director, and Director of the Center for Bioethics and Social Sciences. Her many contributions to the study of gender discrimination in medicine include JAMA articles Gender Differences in the Salaries of Physician Researchers, and Sexual Harassment and Discrimination Experiences of Academic Medical Faculty.

Anna Kirkland, PhD, JD, U-M LSA Arthur F. Thurnau Professor of Women’s Studies, Director, Women’s and Gender Studies and School of Public Health Professor in Health Management and Policy by courtesy appointment. Prof. Kirkland served as a committee member on the National Academies panel charged with studying sexual harassment in the STEM fields of academia, published in June 2018 as Sexual Harassment of Women: Climate, Culture, and Consequences in Academic Sciences, Engineering, and Medicine.

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Lecture / Discussion Fri, 17 Sep 2021 11:10:58 -0400 2021-09-24T12:00:00-04:00 2021-09-24T13:00:00-04:00 Off Campus Location Biostatistics Lecture / Discussion Picture a scientist
U-M Food Drive for Food Gatherers (September 25, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631612@events.umich.edu Event Begins: Saturday, September 25, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-25T08:00:00-04:00 2021-09-25T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
U-M Food Drive for Food Gatherers (September 26, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631613@events.umich.edu Event Begins: Sunday, September 26, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-26T08:00:00-04:00 2021-09-26T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
Understanding the Imbalance of Supply and Demand of Transplant Organs in the US: A Multidisciplinary Team Approach (September 27, 2021 4:30pm) https://events.umich.edu/event/87038 87038-21638191@events.umich.edu Event Begins: Monday, September 27, 2021 4:30pm
Location: Industrial and Operations Engineering Building
Organized By: Center for Healthcare Engineering & Patient Safety (CHEPS)

Organ donor shortage is expected to grow as demand for organs outweighs supply. However how various levers impact supply and demand of organs in the present and the future is not understood. Our team has created a framework to better understand some of the many aspects that impact supply and demand of organs to gain insights into how this issue may be ameliorated in the present and the future. Using data from various sources including Organ Procurement and Transplantation Network database, the U.S. Census Bureau and the National Health and Nutrition Examination Survey (among others), we explore how changes in donation rates (including implied consent) may impact the supply/demand imbalance.

Mariel Lavieri, Ph.D., Associate Professor of Industrial and Operations Engineering, University of Michigan
Mariel Lavieri joined the faculty at the University of Michigan - Ann Arbor in 2009. In her work, she applies operations research to healthcare topics. Her most recent research focuses on medical decision making, in particular on determining optimal monitoring and treatment by explicitly modeling stochastic disease progression.

David Hutton, Ph.D., Associate Professor School of Public Health & Industrial and Operations Engineering, University of Michigan
David Hutton holds a PhD from Stanford’s department of Management Science and Engineering with a focus on health policy modeling. David’s current research is focused on health policy and medical decision making, in particular the use of mathematical models to assist with the allocation of resources for health.

Neehar Parikh, MD, Gastroenterology, Internal Medicine, Transplant Hepatology, Michigan Medicine
Dr. Parikh’s clinical and research work focuses on treatment and outcomes for hepatobiliary malignancies. He has research interests in liver cancer treatment allocation, treatment effectiveness modeling, cost and cost-effectiveness of healthcare interventions, quality of life, liver transplantation and allocation, and cancer screening and prevention.

Luke DeRoos, Ph.D. Student, Industrial and Operations Engineering, University of Michigan
Luke DeRoos is a PhD student under the guidance of Dr. Mariel Lavieri. His research focuses on improving the quality of and access to healthcare.

Wesley J. Marrero Colón, Ph.D., Postdoctoral Research Fellow, MGH Institute for Technology Assessment, Harvard Medical School
Wesley J. Marrero Colón’s current research focuses on the usage and creation of data-driven methods to make better decisions and aims to address healthcare applications from a population and patient perspective.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach. For the Zoom link and password and to be added to the weekly e-mail for the series, please RSVP. For additional questions, contact CHEPSseminar@umich.edu. Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Mon, 20 Sep 2021 13:24:29 -0400 2021-09-27T16:30:00-04:00 2021-09-27T17:30:00-04:00 Industrial and Operations Engineering Building Center for Healthcare Engineering & Patient Safety (CHEPS) Lecture / Discussion Mariel Lavieri, Ph.D., David Hutton, Ph.D., Neehar Parikh, MD, Luke DeRoos, Ph.D. Student, Wesley J. Marrero Colón, Ph.D.
Department of Computational Medicine & Bioinformatics Weekly Seminar (September 29, 2021 4:00pm) https://events.umich.edu/event/87515 87515-21642906@events.umich.edu Event Begins: Wednesday, September 29, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

Human complex traits result from genetic and environmental factors, and from their interactions. Many of these effects are mediated by changes in gene regulation. Indeed, most genetic variants associated with complex trait variation in humans are in regulatory regions. I will present some of our recent studies on gene-environment interactions in gene regulation, with a specific focus on cardiovascular health. I will present evidence that gene-environment interactions in molecular phenotypes are frequent, account for a substantial portion of complex trait variation and modify genetic risk for disease.

Research Focus:

My lab is interested in understanding the genetic and molecular basis of inter-individual and inter-population differences in complex phenotypes. We combine evolutionary and functional genomics approaches to study intermediate phenotypes (e.g.: transcription factor binding, gene expression, protein secretion, etc.) and how they are affected by gene-environment interactions. Our research is funded by the NIH.

Zoom link: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Fri, 24 Sep 2021 14:01:53 -0400 2021-09-29T16:00:00-04:00 2021-09-29T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual Francesca Luca, PhD (Wayne State University)
How Data Science, LHS, and Precision Health Can Enhance Clinical Practice (September 30, 2021 11:00am) https://events.umich.edu/event/85706 85706-21628303@events.umich.edu Event Begins: Thursday, September 30, 2021 11:00am
Location: Off Campus Location
Organized By: Precision Health

How do we connect research findings and data to clinical care? This is the first in a series of webinars connecting health research, data, and clinical care.

Please join us to learn about the role of learning health systems (LHS) in health care and precision health (PH). Discover more about the potential role of data science in clinical practice and research within different aspects of the learning cycle. You'll also hear about opportunities and limitations of current data infrastructure (including EHR data) for precision health, and implications of using EHR to support practice change, including clinical decision support. And you'll walk away understanding dimensions of data quality and possible metrics for assessing the quality of data for particular PH questions. Finally, this is an opportunity to understand the role of data governance and (clinically oriented) learning communities in data quality and precision health research.

This webinar, led by Gretchen Piatt, Associate Professor, LHS, and Rachel Richesson, Professor, LHS, is ideal for clinicians, students in all health sciences, researchers, and those in supporting roles.

*Please use @umich.edu email to register*

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Livestream / Virtual Tue, 24 Aug 2021 16:14:39 -0400 2021-09-30T11:00:00-04:00 2021-09-30T12:00:00-04:00 Off Campus Location Precision Health Livestream / Virtual Sept. 2021 webinar
DCM&B Tools and Technology Seminar (September 30, 2021 12:00pm) https://events.umich.edu/event/85355 85355-21626295@events.umich.edu Event Begins: Thursday, September 30, 2021 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

URL for remote viewing: https://umich-health.zoom.us/j/94886745590?pwd=LzhLU243K2ZhbXNzU1BJRHQ5V25BZz09

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Presentation Wed, 18 Aug 2021 09:19:10 -0400 2021-09-30T12:00:00-04:00 2021-09-30T13:00:00-04:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
LHS Collaboratory 2021-2022 Kick-off Session (September 30, 2021 12:00pm) https://events.umich.edu/event/84725 84725-21624492@events.umich.edu Event Begins: Thursday, September 30, 2021 12:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Presentation 1
The Learning Health (Record) System

Speaker:
Philip R.O. Payne, PhD, FACMI, FAMIA, FAIMBE, FIAHSI
Janet and Bernard Becker Professor and Director, Institute for Informatics (I2), Associate Dean for Health information and Data Science, Chief Data Scientist, at Washington University in St. Louis

This presentation will explore the ways in Biomedical Data Science and Informatics research are helping to realize the potential of EHR technologies in the context of creating an LHS, from the optimization of workflow and human factors, to the generation of reproducible and systematic clinical phenotypes, to the delivery of emergent knowledge to both providers and patients via advance clinical decision support systems.

Presentation 2
Techniques and Challenges for EHR Phenotyping

Speaker:
Lisa Bastarache, MS
Research Associate Professor Department of Biomedical Informatics,
Vanderbilt University

Electronic health records (EHR) contain a wealth of real world data that can be used for research purposes. However, extracting phenotype information from EHRs can be challenging. EHR phenotyping can be divided into two types: (1) Fast phenotyping which seeks to capture a broad swath of the medical phenome, and is often accomplished using coded EHR data (e.g. billing codes) and (2) slow phenotyping that seeks to achieve high precision and recall for a single phenotype, and often uses multiple EHR data types (e.g. medications, text, lab results). This talk will describe specific use-cases for both fast and slow phenotyping, and review challenges that are commonly encountered in creating research-grade EHR phenotypes.

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Lecture / Discussion Mon, 27 Sep 2021 11:13:17 -0400 2021-09-30T12:00:00-04:00 2021-09-30T13:30:00-04:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion LHS Collaboratory Logo
EIHS Lecture: Beyond the Asylum: Mapping Circuits of Recovery and Relapse in Colonial Vietnam (September 30, 2021 4:00pm) https://events.umich.edu/event/85451 85451-21626470@events.umich.edu Event Begins: Thursday, September 30, 2021 4:00pm
Location: Tisch Hall
Organized By: Eisenberg Institute for Historical Studies

This is a hybrid event. Link here for in-person registration (limited): https://myumi.ch/QAkxr
Link here to stream via Zoom: https://myumi.ch/nbW03

Description: In colonial Vietnam, patients would spend years circulating in and out of mental asylums, defying our sense of these spaces as total institutions. This talk follows the movements of patients out of the asylum to ask what the dynamics of patient release can tell us about the varied meanings and lived experiences of recovery in a colonial society. What possibilities are opened when we shift our focus from confinement to release, from the asylum to its social world, from cure to healing?

Biography: Claire E. Edington is an associate professor of history at the University of California, San Diego, where she specializes in the history of public health, the history of modern Southeast Asia, and the colonial and postcolonial studies of science and medicine. Her first book, Beyond the Asylum: Mental Illness in French Colonial Vietnam, was published by Cornell University in 2019. She received her PhD from the Departments of Sociomedical Sciences and History from Columbia University in 2013.

This event presented by the Eisenberg Institute for Historical Studies. It is made possible in part by a generous contribution from Kenneth and Frances Aftel Eisenberg.

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Lecture / Discussion Tue, 14 Sep 2021 07:41:13 -0400 2021-09-30T16:00:00-04:00 2021-09-30T18:00:00-04:00 Tisch Hall Eisenberg Institute for Historical Studies Lecture / Discussion Claire Edington
"Medicare for All: A Citizen’s Guide" by Dr. Abdul El-Sayed (October 1, 2021 10:00am) https://events.umich.edu/event/85050 85050-21625507@events.umich.edu Event Begins: Friday, October 1, 2021 10:00am
Location: Off Campus Location
Organized By: Osher Lifelong Learning Institute (50+)

There are few issues as consequential in the lives of Americans as healthcare—and few issues more politically vexing. Every single American will interact with the healthcare system at some point in their lives, and most people will find that interaction less than satisfactory. And yet for every dollar spent in our economy, 18 cents go to healthcare. What are we paying for, exactly?

Healthcare policy is notoriously complex, but what Americans want is simple: good healthcare that's easy to use and doesn't break the bank.

Medicare for All is the leading proposal to achieve universal health coverage in America. But what is it exactly? How would it work? More importantly, is it practical or practicable?

“Medicare for All: A Citizen's Guide” goes beyond partisan talking points to offer a serious examination of how Medicare for All would transform the way we give, receive, and pay for healthcare in America.

Dr. Abdul El-Sayed is a physician, epidemiologist, educator, author, speaker, and podcast host. His newsletter, “The Incision”, cuts to the heart of the trends shaping our moment. He is a commentator at CNN. In addition to “Medicare for All” he has written “Healing Politics”, calling for a politics of empathy to cure our epidemic of insecurity. He is the host of “America Dissected,” a podcast by Crooked Media, which goes beyond the headlines to explore what really matters for our health. He is a Senior Fellow at the FXB Center for Health & Human Rights at the Harvard T. H. Chan School of Public Health, and a Scholar-in-Residence at Wayne State University and American University, teaching at the intersection of public health, public policy, and politics. He is formerly the Health Director for the City of Detroit and candidate for Governor of Michigan in 2018.

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Class / Instruction Mon, 09 Aug 2021 14:06:03 -0400 2021-10-01T10:00:00-04:00 2021-10-01T12:00:00-04:00 Off Campus Location Osher Lifelong Learning Institute (50+) Class / Instruction OLLI Reads
EIHS Workshop: Historicizing Health: Wellness, Illness, and Recovery Across Time and Space (October 1, 2021 12:00pm) https://events.umich.edu/event/85452 85452-21626473@events.umich.edu Event Begins: Friday, October 1, 2021 12:00pm
Location: Tisch Hall
Organized By: Eisenberg Institute for Historical Studies

This is a hybrid event. Link here for in-person registration (limited): https://myumi.ch/r8Mb9
Link here to stream via Zoom: https://myumi.ch/erl9p

Description: “Health,” as a historical concept, has multiple meanings. It may denote a functional body, accompanied by feelings of comfort and absence of disease. It also has mental, spiritual, and social dimensions to express the overall wellness of physical bodies in the context of everyday life and environment. Moreover, health extends beyond the individual, affecting communities and geopolitical entities. Overall, health is a dynamic process that is often represented via a graduated scale or continuous spectrum ranging from wellness and optimal functioning at one end, to disability and illness culminating in death at the other. This EIHS graduate student workshop explores the historical construction of the concept of health and related notions such as therapy, disability, and recovery. A wide range of geographical and temporal settings are considered, including Sassanian Babylonia, the Roman Empire, medieval and early modern England, and the twentieth-century United States.

Panelists:
• Grace Argo (Graduate Student, History, University of Michigan)
• Alex Burnett (Graduate Student, History, University of Michigan)
• Erin Johnson (Graduate Student, History, University of Michigan)
• Emily Lamond (Graduate Student, Ancient History, University of Michigan)
• Hannah Roussel (Graduate Student, History, University of Michigan)
• Stephie Yoon (Graduate Student, History, University of Michigan)
• Melanie S. Tanielian (moderator; Associate Professor, History, University of Michigan)

This event presented by the Eisenberg Institute for Historical Studies. It is made possible in part by a generous contribution from Kenneth and Frances Aftel Eisenberg.

Image: Skeletal Illustration, Andreas Vesalius, De Humani Corporis Fabrica, 1543, (Special Collections, University of Michigan).

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Workshop / Seminar Tue, 14 Sep 2021 07:43:06 -0400 2021-10-01T12:00:00-04:00 2021-10-01T14:00:00-04:00 Tisch Hall Eisenberg Institute for Historical Studies Workshop / Seminar Skeletal Illustration
RNA Innovation Seminar (October 4, 2021 4:00pm) https://events.umich.edu/event/86162 86162-21631753@events.umich.edu Event Begins: Monday, October 4, 2021 4:00pm
Location: 1027 E. Huron Building
Organized By: Center for RNA Biomedicine

"Fluorescent nucleoside analogues with new properties"

HYBRID EVENT
in-person: Forum Hall, Palmer Commons
Zoom: https://umich.zoom.us/webinar/register/WN__vvE2dtHQi-R3h05JUHBzQ

ABSTRACT
Fluorescent nucleoside analogues (FNAs) are powerful probes for studying the structure and dynamics of nucleic acids, which are vital to understanding RNA function, DNA damage repair, nucleic acid–protein interactions, regulatory mechanisms for gene expression, and other aspects of nucleic acid function. Existing FNAs are prone to quenching by base pairing and stacking, are clustered at the blue–green end of the visible spectrum, and have limited brightness as compared with conventional fluorophores. Studies of nucleic acid function would benefit greatly from overcoming these limitations. We have designed, synthesized, and studied a series of fluorescent pyrimidine analogues, aiming to address these limitations and develop a detailed understanding of the relationships between chemical structure and fluorescent responses to local environment in nucleic acids. Included in this series is a tricyclic cytidine analogue DEAtC that is nearly non-fluorescent as a nucleoside, but responds to matched base pairing and stacking with a fluorescence turn-on. A chlorinated tricyclic cytidine 8-Cl-tCO reports on local environment by changes in the vibrational fine structure of its emission spectra. To address the problem of limited brightness, we have design and synthesized a new NFA that we call ABN, which has a conjugated push–pull system similar to those found in bright fluorophores such as rhodamines. ABN is the brightest known FNA when present in duplex nucleic acids, and it is readily detected in single-molecule fluorescence measurements using both 1-photon and 2-photon excitation. Collectively, these FNAs offer new capabilities for biophysical studies on nucleic acids. Comparisons of their structure and properties help to reveal mechanisms for fluorescence changes in response to local environment in nucleic acids.

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Lecture / Discussion Fri, 10 Sep 2021 11:29:04 -0400 2021-10-04T16:00:00-04:00 2021-10-04T17:00:00-04:00 1027 E. Huron Building Center for RNA Biomedicine Lecture / Discussion Byron Purse, San Diego State University
Applications of Artificial Intelligence in Low-Resource Settings (October 4, 2021 4:30pm) https://events.umich.edu/event/87334 87334-21641174@events.umich.edu Event Begins: Monday, October 4, 2021 4:30pm
Location: Off Campus Location
Organized By: Center for Healthcare Engineering & Patient Safety (CHEPS)

In response to the development of new highly effective but expensive treatments, policymakers, payors, and health systems are considering novel and pragmatic ways to provide high-cost treatments to patients. One approach targets treatments using AI/ML-based approaches to those most likely to benefit (i.e., risk stratify to identify those at highest risk of complications); another is to optimize the delivery of treatment to provide high-value care while containing costs. In addition, there may be broader applicability of AI/ML-guided care in low resource settings, such as low- and middle-income countries. AI/ML can do this in a variety of settings and is exemplified in the article provided. This seminar will outline one such approach using a treatment for inflammatory bowel disease (IBD) as a use case.

Dr. Akbar K. Waljee, is a Professor in the Department of Internal Medicine Dr. Waljee serves as the Associate Director of the Data and Methods Hub and the Director of the Michigan Integrated Center for Health Analytics and Medical Prediction (MiCHAMP) both at the UM Institute for Healthcare Policy & Innovation (IHPI). He also serves as the Director of the VA CCMR Prediction Modeling Unit (PMU) and, clinically, he is the Director of the Inflammatory Bowel Disease clinic both at the VA Ann Arbor Healthcare System.

Dr. Waljee was born in Kenya and moved to the United States to complete his undergraduate and medical degrees at Emory University in Atlanta, GA. He then completed his residency and fellowship at the University of Michigan. Dr. Waljee holds a Master’s degree in Health Services Research from the University of Michigan and completed a heath care policy fellowship at the Center for Health and Research Transformation.

Dr. Waljee’s work is at the forefront of using machine learning and deep learning techniques to improve healthcare access, quality, and efficiency (high-value care) in resource constrained settings. He uses novel machine learning techniques to implement decision support systems and tools that facilitate more personalized care for disease management and healthcare utilization to ultimately deliver efficient, effective and equitable therapy for chronic diseases. To test and advance these principles, he built operational programs that are guiding—and improving—patient care in costly gastroenterology and liver disorders in under-resourced settings both domestically and abroad.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach. For the Zoom link and password and to be added to the weekly e-mail for the series, please RSVP. For additional questions, contact CHEPSseminar@umich.edu. Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Mon, 04 Oct 2021 10:32:13 -0400 2021-10-04T16:30:00-04:00 2021-10-04T17:30:00-04:00 Off Campus Location Center for Healthcare Engineering & Patient Safety (CHEPS) Lecture / Discussion Akbar Waljee, MD, MSc
Covid Vax Chat with the White House (October 4, 2021 5:30pm) https://events.umich.edu/event/87748 87748-21645526@events.umich.edu Event Begins: Monday, October 4, 2021 5:30pm
Location: Off Campus Location
Organized By: Covid Campus Coalition

Join Surgeon General Dr. Vivek Murthy and the Covid Campus Coalition in an interactive conversation about COVID-19 vaccines and college life! Ask questions and meet students from universities across the country!

About us: The Covid Campus Coalition is a national student-run effort to provide college students with accurate, timely information about the COVID-19 pandemic and vaccines. Our goal is to combat misconceptions about the COVID-19 vaccine and empower students to make fully informed decisions about their own health!

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Lecture / Discussion Thu, 30 Sep 2021 16:09:35 -0400 2021-10-04T17:30:00-04:00 2021-10-04T18:00:00-04:00 Off Campus Location Covid Campus Coalition Lecture / Discussion Event Flyer
Premed Roundup- LSA Honors Program (October 4, 2021 6:00pm) https://events.umich.edu/event/85379 85379-21626331@events.umich.edu Event Begins: Monday, October 4, 2021 6:00pm
Location: Off Campus Location
Organized By: LSA Honors Program

Hello LSA Honors Program students!

Are you considering a career in medicine or in another health care profession and wondering where to get started? If so, then we invite you to participate in an information session brought to you by Stephanie Chervin, Honors premed advisor, to learn about:

• Pre-health resources.
• Medical school course requirements.
• Timing and strategies for the long and short term.
• Choosing a major. Does it have to be in science?
• Explorations in patient and clinical exposure.
• Research opportunities.

This session will be live-virtual and you will have the chance to ask questions of the speaker. Event will be repeated on Oct. 4, 6 and 11, 2021

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Workshop / Seminar Wed, 18 Aug 2021 16:34:41 -0400 2021-10-04T18:00:00-04:00 2021-10-04T19:00:00-04:00 Off Campus Location LSA Honors Program Workshop / Seminar Doctor with a stethoscope
The Futurescape of Medicine Lecture Series (October 5, 2021 10:00am) https://events.umich.edu/event/85071 85071-21625545@events.umich.edu Event Begins: Tuesday, October 5, 2021 10:00am
Location: Off Campus Location
Organized By: Osher Lifelong Learning Institute (50+)

The goal of this lecture series is to provide educational insights about future developments in five different areas of medical care.

Lecture #2 - Current and Future Surgical Options for Hip and Knee Replacements. Brian Hallstrom is our speaker.

Attention will be paid to current best practices, ethical implications of new technologies, promotion of consumer education and choices, and financial aspects of delivery in the context of value-based care. A lively discussion is anticipated for each lecture regarding the many issues raised by these trends and technologies.”

Preregistration is required via the OLLI website or phone. A link to access the lecture will be e-mailed prior to the event.

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Class / Instruction Tue, 10 Aug 2021 12:15:40 -0400 2021-10-05T10:00:00-04:00 2021-10-05T11:30:00-04:00 Off Campus Location Osher Lifelong Learning Institute (50+) Class / Instruction Futurescape of Medicine
The Use of Cannabis for Athlete Health and Performance (October 5, 2021 1:00pm) https://events.umich.edu/event/87561 87561-21644078@events.umich.edu Event Begins: Tuesday, October 5, 2021 1:00pm
Location: Off Campus Location
Organized By: U-M Office of Research

Join the Exercise & Sport Science Initiative (ESSI) for a seminar focused on the use of cannabis for athlete health and performance. Experts will discuss how cannabis is currently regulated in sports; why medical cannabis has been proposed for use in treating chronic and acute pain, as opposed to other treatment strategies; how CBD and THC affect mental and physical health and athletic performance, both positively and negatively; the molecular mechanisms of how CBD and THC work; how THC and CBD get metabolized differently depending on how they are administered (e.g., topical, oral, or inhalation); and where the future is headed in terms of the use of medical cannabis in elite sports. Registration link: https://umich.zoom.us/webinar/register/WN_5zPjIcJbSReoX5lGuoU0hw

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Livestream / Virtual Mon, 27 Sep 2021 10:19:35 -0400 2021-10-05T13:00:00-04:00 2021-10-05T14:00:00-04:00 Off Campus Location U-M Office of Research Livestream / Virtual Athlete using CBD oil
Premed Roundup: LSA Honors Program (October 6, 2021 2:00pm) https://events.umich.edu/event/85380 85380-21626332@events.umich.edu Event Begins: Wednesday, October 6, 2021 2:00pm
Location: Off Campus Location
Organized By: LSA Honors Program

Hello LSA Honors Program students!

Are you considering a career in medicine or in another health care profession and wondering where to get started? If so, then we invite you to participate in an information session brought to you by Stephanie Chervin, Honors premed advisor, to learn about:

• Pre-health resources.
• Medical school course requirements.
• Timing and strategies for the long and short term.
• Choosing a major. Does it have to be in science?
• Explorations in patient and clinical exposure.
• Research opportunities.

This session will be live-virtual and you will have the chance to ask questions of the speaker. Event will be repeated on Oct. 4, 6 and 11, 2021

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Workshop / Seminar Wed, 18 Aug 2021 16:38:56 -0400 2021-10-06T14:00:00-04:00 2021-10-06T15:00:00-04:00 Off Campus Location LSA Honors Program Workshop / Seminar stethoscope
“This is Our Lane: talking with Patients about Racism” and “Structural Racism & the Impact on Incarcerated Midlife Women” (October 6, 2021 3:00pm) https://events.umich.edu/event/87467 87467-21642281@events.umich.edu Event Begins: Wednesday, October 6, 2021 3:00pm
Location: Off Campus Location
Organized By: Center for Midlife Science

Registration required: https://umich.zoom.us/webinar/register/WN_7wXT6ve8S2qqy4dAKi1ckA

Moderators: Sherri-Ann M. Burnett-Bowie, MD, MPH, Department of Medicine, Massachusetts General Hospital & Harvard Medical School; and Gloria Bachmann, MD, Rutgers Robert Wood Johnson Medical School.

Speakers: “This is Our Lane: talking with Patients about Racism” with Michelle S. Diop, MD, ScM, Department of Medicine, Massachusetts General Hospital & Harvard Medical School; and Sascha N. Murillo MD, Department of Medicine, Massachusetts General Hospital & Harvard Medical School; and “Structural Racism and the Impact on Incarcerated Midlife Women” with Juana Hutchinson-Colas, MD, Rutgers Robert Wood Johnson Medical School.

Location: This will be an online event. Please register for more information.

Sponsored by: Women’s Midlife Health (journal), Center for Midlife Science at the University of Michigan, Massachusetts General Hospital Department if Medicine Diversity and Inclusion Board.

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Lecture / Discussion Thu, 23 Sep 2021 17:27:30 -0400 2021-10-06T15:00:00-04:00 2021-10-06T16:00:00-04:00 Off Campus Location Center for Midlife Science Lecture / Discussion Webinar Series on Structural Racism and Midlife Health
DCM&B Tools and Technology Seminar (October 7, 2021 12:00pm) https://events.umich.edu/event/85356 85356-21626297@events.umich.edu Event Begins: Thursday, October 7, 2021 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

This presentation will be given remotely, with the livestream available for group viewing in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

URL for remote viewing: https://umich-health.zoom.us/j/94886745590?pwd=LzhLU243K2ZhbXNzU1BJRHQ5V25BZz09

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Presentation Sun, 03 Oct 2021 10:17:29 -0400 2021-10-07T12:00:00-04:00 2021-10-07T13:00:00-04:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
BME 500 Seminar: Imaging neural, hemodynamic, and cerebrospinal fluid dynamics in the sleeping brain (October 7, 2021 4:00pm) https://events.umich.edu/event/87782 87782-21645945@events.umich.edu Event Begins: Thursday, October 7, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Sleep is essential for cognition and maintenance of healthy brain function. Sleep changes diverse aspects of brain physiology, and exhibits unique behavioral states, electrophysiological oscillations, vascular dynamics, and waste clearance properties. Our research integrates multiple neuroimaging technologies to understand the neural circuits controlling sleep and the consequences of sleep for brain physiology. To investigate how these multiple aspects might be coupled during sleep, we used simultaneous fast fMRI and EEG to measure fluid and neural dynamics in the human brain. We found a coherent pattern of coupled electrophysiological, hemodynamic, and cerebrospinal fluid (CSF) dynamics that appears during non-rapid eye movement sleep. Our results demonstrate that the sleeping brain exhibits waves of CSF flow on a macroscopic scale, and suggests a neural mechanism that can regulate CSF flow. Next, using fast fMRI at ultra-high field (7 Tesla), we tracked subsecond dynamics throughout thalamocortical networks across transitions between sleep and wakefulness. We identified a temporal sequence of activity across individual thalamic nuclei that appears at the moment of awakening from sleep and predicts subsequent behaviour. Together, these studies develop multimodal imaging approaches for tracking human brain physiology at fast timescales, and identify neural and fluid dynamics unique to the sleeping brain.

Zoom Link: https://umich.zoom.us/j/97723483179

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Lecture / Discussion Mon, 04 Oct 2021 09:29:19 -0400 2021-10-07T16:00:00-04:00 2021-10-07T17:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Seminar Event
Premed Roundup: LSA Honors Program (October 11, 2021 12:00pm) https://events.umich.edu/event/85381 85381-21626333@events.umich.edu Event Begins: Monday, October 11, 2021 12:00pm
Location: Off Campus Location
Organized By: LSA Honors Program

Hello LSA Honors Program students!

Are you considering a career in medicine or in another health care profession and wondering where to get started? If so, then we invite you to participate in an information session brought to you by Stephanie Chervin, Honors premed advisor, to learn about:

• Pre-health resources.
• Medical school course requirements.
• Timing and strategies for the long and short term.
• Choosing a major. Does it have to be in science?
• Explorations in patient and clinical exposure.
• Research opportunities.

This session will be live-virtual and you will have the chance to ask questions of the speaker. Event will be repeated on Oct. 4, 6 and 11, 2021

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Workshop / Seminar Wed, 18 Aug 2021 16:42:53 -0400 2021-10-11T12:00:00-04:00 2021-10-11T13:00:00-04:00 Off Campus Location LSA Honors Program Workshop / Seminar syringe
Engineering Machine Learning for Medicine: Developing, Deploying, and Evaluating Dynamic Prediction Models (October 11, 2021 4:30pm) https://events.umich.edu/event/87726 87726-21645395@events.umich.edu Event Begins: Monday, October 11, 2021 4:30pm
Location: Industrial and Operations Engineering Building
Organized By: Center for Healthcare Engineering & Patient Safety (CHEPS)

The development, validation, and implementation of machine learning (ML) models for use in healthcare requires a strong understanding of clinical needs, analytical methods, and systems engineering. A deep dive into the development of a ML model for predicting return to work of patients experiencing occupational injuries will be used to anchor a broad discussion on engineering ML for medicine. This discussion will cover the development of a dynamic prediction model using workers compensation claims data. Additionally, we will briefly cover issues surrounding ML model task framing, validation, and implementation.

Erkin Ötleş is a Medical Scientist Training Program Fellow (MD-PhD student) at the University of Michigan. He has completed three years of medical school training and is currently a PhD candidate in the department of Industrial and Operations Engineering. His research lies at the intersection of computer science, industrial engineering, and medicine, centered on creating machine learning and artificial intelligence tools for patients, physicians, and health systems. Erkin’s dissertation work focuses on the development, implementation, and prospective usage of dynamic health outcome prediction models (e.g. early warning systems). He is co-advised by Dr. Brian Denton (Industrial and Operations Engineering) and Dr. Jenna Wiens (Computer Science and Engineering). Erkin has a professional background in health IT - having managed electronic health record development and healthcare data science teams. He holds a Master’s of Industrial Engineering from the University of Wisconsin. After completion of his MD-PhD training, Erkin plans on pursing medical residency training in emergency medicine.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach. For the Zoom link and password and to be added to the weekly e-mail for the series, please RSVP. For additional questions, contact CHEPSseminar@umich.edu. Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Mon, 04 Oct 2021 10:26:26 -0400 2021-10-11T16:30:00-04:00 2021-10-11T17:30:00-04:00 Industrial and Operations Engineering Building Center for Healthcare Engineering & Patient Safety (CHEPS) Lecture / Discussion Erkin Ötleş, MD/Ph.D. Student
Examining the Health Reform Monitoring Survey and the Well-Being and Basic Needs Survey Presented by the Urban Institute (October 12, 2021 2:00pm) https://events.umich.edu/event/87749 87749-21645527@events.umich.edu Event Begins: Tuesday, October 12, 2021 2:00pm
Location: Off Campus Location
Organized By: Inter-university Consortium for Political and Social Research

Join the Health and Medical Care Archive (HMCA) at the Inter-university Consortium for Political and Social Research (ICPSR) on October 12 at 2:00 pm EDT for a free webinar, “Examining the Health Reform Monitoring Survey and the Well-Being and Basic Needs Survey Presented by the Urban Institute” featuring Stephan Zuckerman and Michael Karpman. The webinar is hosted by HMCA, a data repository funded by the Robert Wood Johnson Foundation.

Participants will get an overview of the surveys, learn about key findings from the latest data, and discover ways these studies can be used in health research. Participants will learn about the resources available on the RWJF and HMCA websites and have the opportunity to ask questions.

Register with this link: https://myumi.ch/YyEe2

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Presentation Thu, 30 Sep 2021 16:44:15 -0400 2021-10-12T14:00:00-04:00 2021-10-12T15:00:00-04:00 Off Campus Location Inter-university Consortium for Political and Social Research Presentation Webinar Announcement with the Urban Institute and the Institute for Social Research on the Health Reform Monitoring Survey and the Well-Being and Basic Needs Survey
Department of Computational Medicine & Bioinformatics Weekly Seminar (October 13, 2021 4:00pm) https://events.umich.edu/event/86441 86441-21634316@events.umich.edu Event Begins: Wednesday, October 13, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

Understanding the genetic and molecular architecture of human disease is accelerated by robust model development and large-scale molecular profiling. I will present two studies leveraging big data analytics or automated machine learning to dissect human disease complexities: 1) Molecular and clinical signatures of SARS-CoV-2 infection in the US marines. This analysis revealed strong antiviral innate immunity set point in females contributing to sex differences in both molecular and clinical response to SARS-CoV-2 infection. A set of accurate biomarkers capable of detecting PCR false negative infections was implemented on small footprint devices. 2) Automated machine learning to interpret the effects of genetic variants. An automated framework, AMBER, was developed for efficiently searching neural network architectures to model genomic sequences. AMBER is useful in various biological applications, including fine mapping variants, partitioning genetic heritability, and in personalized medicine enabled by CRISPR/Cas9 genome editing. Together, these efforts demonstrate quantitative methods coupled with large-scale biomedical data as an effective avenue to decode human regulatory and disease biology.

Short Bio:

Frank Zhang is a Flatiron research fellow with Olga Troyanskaya at the Simons Foundation and Princeton University since 2019. Prior to that, he obtained his PhD at UCLA with Yi Xing. His research focuses on machine learning and statistical method developments for the prediction and interpretation of human molecular and genetic variations using biological big data. Recently, he works on adopting and developing cutting-edge neural architecture search methods to automate the design of deep neural networks in genomics. He is also interested in making deep learning in biomedicine more interpretable and equitable.

Zoom link: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Tue, 07 Sep 2021 14:45:38 -0400 2021-10-13T16:00:00-04:00 2021-10-13T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual
DCM&B Tools and Technology Seminar (October 14, 2021 12:00pm) https://events.umich.edu/event/85358 85358-21626298@events.umich.edu Event Begins: Thursday, October 14, 2021 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

In the Molecular Transducers of Physical Activity Consortium (MoTrPAC), we seek to understand the acute exercise response at the molecular level. In our first multi-omics dataset—a 15 tissue dataset from 6-month-old rats—there was evidence that circadian rhythms were contributing to data signatures, and thus, our ability to differentiate these circadian patterns from our primary measurement—the acute exercise response. To quantify the effects, we created distinct models for acute exercise response and circadian rhythm. We combined the models and allowed them to simultaneously compete for the percent variance explained of gene expression patterns in bulk RNA sequencing data. Analyses were performed on every gene and every tissue. Preliminary evidence suggests that our models were on the right track; for instance, the variances of many known circadian genes (in human and mouse) were primarily explained by the circadian model. However, more analyses are required to rigorously vet these models. We hope these techniques of competing models encourage others to employ similar strategies to distinguish unintended cofounding factors in experiments.

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

URL for remote viewing: https://umich-health.zoom.us/j/94886745590?pwd=LzhLU243K2ZhbXNzU1BJRHQ5V25BZz09

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Presentation Fri, 24 Sep 2021 15:26:28 -0400 2021-10-14T12:00:00-04:00 2021-10-14T13:00:00-04:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
"No Cure for Being Human with Kate Bowler" (October 18, 2021 12:00pm) https://events.umich.edu/event/85152 85152-21625637@events.umich.edu Event Begins: Monday, October 18, 2021 12:00pm
Location: Off Campus Location
Organized By: The University of Michigan Medical School Program on Health, Spirituality and Religion

The world loves us when we are good, better, best, but what about when we get sick, lose someone we love, or life hasn't turned out like we thought is should? Duke Professor Kate Bowler offers a richer understanding of hope in the face of uncertainty, despair, and suffering as we being to understand that life is a chronic condition and there is no cure for being human.

Kate Bowler is a New York Times bestselling author, host of a podcast Everything Happens, and Duke University professor. After being unexpectedly diagnosed with Stage IV cancer at age 35, she wrote Everything Happens for a Reason (and Other Lies I've Loved), which tells the story of her struggle to understand the personal and intellectual dimensions of the American belief that all tragedies are tests of character. Her latest book, No Cure For Being Human (and Other Truths I Need to Hear), grapples with her diagnosis, her ambition, and her faith as she tries to comes to terms with limitations in a culture that says anything is possible.

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Workshop / Seminar Mon, 11 Oct 2021 07:31:40 -0400 2021-10-18T12:00:00-04:00 2021-10-18T13:00:00-04:00 Off Campus Location The University of Michigan Medical School Program on Health, Spirituality and Religion Workshop / Seminar Kate Bowler, PhD
RNA Innovation Seminar: Tim Stasevich, Ph.D., Colorado State University (October 18, 2021 4:00pm) https://events.umich.edu/event/86166 86166-21631758@events.umich.edu Event Begins: Monday, October 18, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

KEYWORDS: translational regulation, gene expression, fluorescence microscopy, intrabodies, single-molecule imaging

ABSTRACT: My lab is creating technology to image mRNA translation in real time and with single-molecule precision in living cells. In this talk, I will introduce our technology and describe how it can be used to amplify fluorescence from newly synthesized proteins as they are being translated from single mRNAs. I will show how we quantify these signals to determine the size, shape, subcellular localization, and mobilities of mRNA translation sites, as well as their protein synthesis dynamics. I will then highlight a few recent applications of our technology, focusing mainly on a new biosensor we have developed to quantify how individual regulatory factors impact single mRNA translation dynamics. Using this biosensor, we provide evidence that human Argonaute2 (Ago2) shuts down translation by down regulating translation initiation on the minutes timescale and helping usher translationally silent mRNAs into P-bodies on the hours timescale. I will conclude by discussing new fluorescent intrabodies my lab is engineering to light up nascent and mature proteins in multiple colors. As these intrabodies can be encoded on plasmids, they can easily be adapted by other labs to image gene activity in diverse living systems.
Timothy J. Stasevich is an Associate Professor in the Department of Biochemistry and Molecular Biology at Colorado State University (CSU). His lab uses a combination of advanced fluorescence microscopy, genetic engineering, and computational modeling to study the dynamics of gene regulation in living mammalian cells. His lab helped pioneer the imaging of real-time single-mRNA translation dynamics in living cells1. Dr. Stasevich received his B.S. in Physics and Mathematics from the University of Michigan, Dearborn, and his Ph. D. in Physics from the University of Maryland, College Park. He transitioned into experimental biophysics as a post-doctoral research fellow in the laboratory of Dr. James G. McNally at the National Cancer Institute. During this time, he developed technology based on fluorescence microscopy to help establish gold-standard measurements of live-cell protein dynamics. Dr. Stasevich next moved to Osaka University, where he worked with Dr. Hiroshi Kimura as a Japan Society for the Promotion of Science Foreign Postdoctoral Research Fellow. While there, he helped create technology to image endogenous proteins and their post-translation modifications in vivo. This allowed him to image the live-cell dynamics of epigenetic histone modifications during gene activation for the first time2. Before joining the faculty at CSU, Dr. Stasevich spent a year as a Visiting Fellow at the HHMI Janelia Research Campus, where he applied superresolution fluorescence microscopy to improve the spatiotemporal resolution of endogenous protein imaging in live cells.
1. Morisaki, T. et al. Real-time quantification of single RNA translation dynamics in living cells. Science 352, 1425–1429 (2016).
2. Stasevich, T. J. et al. Regulation of RNA polymerase II activation by histone acetylation in single living cells. Nature 516, 272–275 (2014).

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Lecture / Discussion Thu, 30 Sep 2021 10:17:54 -0400 2021-10-18T16:00:00-04:00 2021-10-18T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Tim Stasevich, Colorado State University
The Futurescape of Medicine Lecture Series (October 19, 2021 10:00am) https://events.umich.edu/event/85073 85073-21625547@events.umich.edu Event Begins: Tuesday, October 19, 2021 10:00am
Location: Off Campus Location
Organized By: Osher Lifelong Learning Institute (50+)

The Futurescape of Medicine Lecture Series
The goal of this lecture series is to provide educational insights about future developments in five different areas of medical care.

Lecture #3 - The Role of 3D Printing in Organ Regeneration.
Our speaker is Jan Stegermann, PhD.

Attention will be paid to current best practices, ethical implications of new technologies, promotion of consumer education and choices, and financial aspects of delivery in the context of value-based care. A lively discussion is anticipated for each lecture regarding the many issues raised by these trends and technologies".

Preregistration is required via the OLLI website or phone. A link to access the lecture will be e-mailed prior to the event.

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Class / Instruction Tue, 10 Aug 2021 12:19:57 -0400 2021-10-19T10:00:00-04:00 2021-10-19T11:30:00-04:00 Off Campus Location Osher Lifelong Learning Institute (50+) Class / Instruction Futurescape of Medicine
LHS Collaboratory (October 19, 2021 12:00pm) https://events.umich.edu/event/87559 87559-21644084@events.umich.edu Event Begins: Tuesday, October 19, 2021 12:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Unlike structured data, unstructured data are often buried within free text clinical narratives that are difficult to analyze and interpret to derive useful insights. Free text cannot be easily categorized in the same way that a structured, numerical data point can, and unstructured data often have nuances that are not easily captured or represented in structured data.

This session will cover methods and techniques for interpreting and converting unstructured text into useful research data using two related, but distinct approaches: (1) Natural Language Processing (NLP), a specialized branch of AI focused on the interpretation and manipulation of human-generated spoken or written data; and (2) information retrieval, which often underlies many search engine technologies. This session will also highlight EMERSE, an open-source information retrieval tool that has been designed to help everyday users work with the free text documents (i.e., clinical notes) in medical records that is now being adopted by other academic medical centers.

Finally, attendees will hear directly from researchers about how they have used these methods and tools to enhance their research by accessing and harnessing the power of unstructured data.

Speakers:
David A. Hanauer, MD, MS, FACMI, FAMIA
Director of MICHR Informatics Program
Associate Professor of Learning Health Sciences


BRINGING DATA TO THE PEOPLE: HOW A SECURE, SELF-SERVICE, FREE-TEXT SEARCH TOOL CAN EMPOWER CLINICAL RESEARCH TEAMS AND IMPROVE PRODUCTIVITY

VG Vinod Vydiswaran, PhD
Associate Professor of Learning Health Sciences
Associate Professor School of Information

PROMISE OF UNSTRUCTURED DATA

Discussants:
Christina Angeles, MD
Assistant Professor, Surgery (General Surgery)
Assistant Professor, Dermatology

Xu Shi, Ph.D.
CCMB Affiliate Faculty
Assistant Professor of Biostatistics, School of Public Health


Leslie Yuan, MPH
Chief Information Officer, Clinical and Translational Science
(CTSI) , University of California San Francisco

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Livestream / Virtual Mon, 27 Sep 2021 11:21:27 -0400 2021-10-19T12:00:00-04:00 2021-10-19T13:30:00-04:00 Off Campus Location Department of Learning Health Sciences Livestream / Virtual Collaboratory logo
Department of Computational Medicine & Bioinformatics Weekly Seminar (October 20, 2021 4:00pm) https://events.umich.edu/event/88315 88315-21652404@events.umich.edu Event Begins: Wednesday, October 20, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

The Ye lab is focused on harnessing the power of single cell and computational genomics to understand how immune cells sense and respond to their environment. Utilizing new experimental methods we have developed to enable multiplexed single-cell sequencing, I will describe results from sequencing 1.2M cells from ~250 samples to understand the cellular and molecular bases of systemic lupus erythmatosus and COVID-19. I will also describe how population scale single cell sequencing can enable dissection of the genetic architecture of gene expression and annotation of disease associated variants. Finally, I’ll touch on novel experimental workflows to further increase the throughput of single-cell genomics and for encoding orthogonal information into single-cell sequencing assays.

Research Overview:

The Ye lab is interested in how the interaction between genetics and environment affect human variation at the level of molecular phenotypes. To study these interactions, the lab couples high-throughput sequencing approaches that measure cellular response under environmental challenges with population genetics where such measurements are collected and analyzed across large patient cohorts. The lab develops novel experimental approaches that enable the large-scale collection of functional genomic data *en masse* and computational approaches that translate the data into novel biological insights. This approach is used to initially study primary human immune cells in both healthy and diseased patients to understand host pathogen interactions and its role in autoimmunity.

Zoom link: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Fri, 15 Oct 2021 14:50:45 -0400 2021-10-20T16:00:00-04:00 2021-10-20T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual
Recognizing & Understanding Imposter Syndrome (October 20, 2021 6:00pm) https://events.umich.edu/event/87828 87828-21647053@events.umich.edu Event Begins: Wednesday, October 20, 2021 6:00pm
Location: Off Campus Location
Organized By: Michigan Medicine Wellness Office

Do you ever wonder if you belong or are you afraid that you aren't talented or good enough? Do you have trouble taking credit for your accomplishments or attribute what you have achieved to luck rather than your own skills? If any of these questions resonate with you, then you may be suffering from imposter syndrome. Join us to discuss what this syndrome is, how it could be affecting you personally, and what actions you can take and habits you can form, to handle the impacts of imposter syndrome.

Please register to receive zoom link: https://sessions.studentlife.umich.edu/track/event/session/45583

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Well-being Mon, 04 Oct 2021 11:36:26 -0400 2021-10-20T18:00:00-04:00 2021-10-20T19:00:00-04:00 Off Campus Location Michigan Medicine Wellness Office Well-being Wellness Office Logo
DCM&B Tools and Technology Seminar (October 21, 2021 12:00pm) https://events.umich.edu/event/85359 85359-21626300@events.umich.edu Event Begins: Thursday, October 21, 2021 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

URL for remote viewing: https://umich-health.zoom.us/j/94886745590?pwd=LzhLU243K2ZhbXNzU1BJRHQ5V25BZz09

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Presentation Wed, 18 Aug 2021 09:43:20 -0400 2021-10-21T12:00:00-04:00 2021-10-21T13:00:00-04:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
NeuroNetwork for Emerging Therapies Mini Symposium Series: The Mind & Music (October 21, 2021 2:00pm) https://events.umich.edu/event/88351 88351-21653429@events.umich.edu Event Begins: Thursday, October 21, 2021 2:00pm
Location: Off Campus Location
Organized By: NeuroNetwork for Emerging Therapies

"Music is to the mind as air is to the body." (Plato)

The next installment of the NeuroNetwork for Emerging Therapies Mini Symposium Series explores the idea of music as the medicine of the mind, from its physical effects to the emotions it elicits. It culminates with a look at how Mott Children’s Hospital is using music therapy to bring.

When: Thursday, October 21, 2:00 PM-2:30 PM
Where: ZOOM
Register: https://michmed.org/O525W

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Lecture / Discussion Mon, 18 Oct 2021 11:24:57 -0400 2021-10-21T14:00:00-04:00 2021-10-21T14:30:00-04:00 Off Campus Location NeuroNetwork for Emerging Therapies Lecture / Discussion Flier for The Mind & Music
Jonathan Cohn: Obamacare and the Unfinished Crusade for Universal Coverage (October 22, 2021 12:00pm) https://events.umich.edu/event/85787 85787-21629000@events.umich.edu Event Begins: Friday, October 22, 2021 12:00pm
Location: Off Campus Location
Organized By: Poverty Solutions

Jonathan Cohn is a senior national correspondent at HuffPost, where he covers politics and policy. He will discuss his book, “The Ten Year War: Obamacare and the Unfinished Crusade for Universal Coverage,” which examines how the Affordable Care Act — better known as “Obamacare” — came to be, why it looks like it does, and what it has meant for average Americans. The virtual conversation is free and open to the public, and U-M students can participate as part of a one-credit course, SWK 503 Section 001.

This event is part of the annual Real-World Perspectives on Poverty Solutions fall speaker series, which introduces key issues regarding the causes and consequences of poverty featuring experts in policy and practice from across the nation, with the goal of encouraging the formation of a broad community of learners to engage in these issues together.

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Livestream / Virtual Mon, 13 Sep 2021 13:22:47 -0400 2021-10-22T12:00:00-04:00 2021-10-22T13:00:00-04:00 Off Campus Location Poverty Solutions Livestream / Virtual Real-World Perspectives on Poverty Solutions 2021 speaker series
CANCELLED: SAVE THE DATE 11th INTERNATIONAL SYMPOSIUM (October 25, 2021 10:00am) https://events.umich.edu/event/84621 84621-21631581@events.umich.edu Event Begins: Monday, October 25, 2021 10:00am
Location:
Organized By: Center for Cell Plasticity and Organ Design

With the current state of things we have decide to cancel the Save the Date for the CPOD International Symposium.

We will update you with the new details as soon as we have a new date.

Thank you for your understanding as we work to make adjustments with the safety of all participants in mind.

Questions/Comments please contact us at: organogenesis@umich.edu

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Conference / Symposium Wed, 01 Sep 2021 10:40:09 -0400 2021-10-25T10:00:00-04:00 2021-10-25T11:00:00-04:00 Center for Cell Plasticity and Organ Design Conference / Symposium CPOD Center for Cell Plasticity and Organ Design
Virtual Job Shadow Program with Dr. Verma (October 26, 2021 8:00am) https://events.umich.edu/event/88063 88063-21654240@events.umich.edu Event Begins: Tuesday, October 26, 2021 8:00am
Location: Off Campus Location
Organized By: LSA Opportunity Hub

Elective surgeries are a cornerstone of our healthcare system that is focused on increasing a patient’s well-being and quality of life. At a time when elective surgeries have been impacted significantly by the pandemic with longer waiting periods, reschedules, or even cancellations, the ability to schedule those potentially life-changing operations in advance has been compromised. Join us for a live look into an arthroscopic rotator cuff surgery as Dr. Nikhil Verma uses advanced surgical techniques to fix a tear in a rotator cuff.


About Dr. Verma   

Dr. Verma is a Sports Medicine and Shoulder physician who performs over 500 procedures per year. He specializes in the treatment of the shoulder, elbow, and knee with an emphasis on advanced arthroscopic reconstructive techniques. He is the Director of the Division of Sports Medicine and Director of the Sports Medicine Fellowship Program at Rush University Medical Center. In addition, Dr. Verma serves as a team physician for the Chicago White Sox and Chicago Bulls.


You should attend this session if you are: 

A liberal arts and/or science undergraduate student
Searching for opportunities to shadow a physician at their clinical practice
Exploring careers and specialties in medicine and healthcare
Looking to explore different medical fields from the perspective of a physician

What you’ll gain from attending:

The opportunity to watch a live surgery performed by a physician and his team using leading technology in the field
The chance to ask the physician questions about the surgery and his work more broadly
Gain insight into how the physicians are handling elective surgeries during COVID-19


RSVP today on the LSA Opportunity Network to reserve your spot to view this live surgery. Seats will be capped at 95. Once your RSVP is complete, you will receive a confirmation email with the event details and a link to access the live viewing 24 hours before the event takes place.

The LSA Opportunity Hub aims to deliver inclusive and accessible experiences and welcomes all LSA students to participate. This event will be hosted on Zoom (learn more about Zoom accessibility) and can be accessed by phone or computer. Presentation materials will be shared in advance and live captioning will be provided. To request other accommodations, or for any further questions, please contact Jordan McAdory at jcmcado@umich.edu so we can make arrangements.

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Livestream / Virtual Wed, 20 Oct 2021 15:40:01 -0400 2021-10-26T08:00:00-04:00 2021-10-26T09:00:00-04:00 Off Campus Location LSA Opportunity Hub Livestream / Virtual Surgery Stock Photo
The Trichloroethylene Metabolite S-(1,2-dichlorovinyl)-L-cysteine Suppresses Inflammatory Pathways in a Macrophage Cell Model: Implications for Immunosuppression During Pregnancy (October 26, 2021 12:00pm) https://events.umich.edu/event/88558 88558-21655081@events.umich.edu Event Begins: Tuesday, October 26, 2021 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

https://umich.zoom.us/s/95313929320

The goal of the environmental research seminar/webinar is to provide an interdisciplinary forum for sharing and critiquing research proposals and preliminary study results.

Dr. Harris is a Research Assistant Professor of Environmental Health Sciences in the School of Public Health at the University of Michigan. Dr. Harris earned his PhD in environmental toxicology from the University of Washington, where he conducted his dissertation research in male reproductive toxicology. As part of his research he helped to develop an in vitro testis cell culture model for studying male reproductive toxicants. He now studies female reproductive toxicology, using a combination of approaches including primary tissue culture models, transcriptomics and metabolomics to investigate molecular mechanisms of toxicant effects on the placenta and fetal membranes. His research aims to advance our understanding of how environmental toxicants contribute to adverse pregnancy outcomes.

https://umich.zoom.us/s/95313929320

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Lecture / Discussion Mon, 25 Oct 2021 11:02:57 -0400 2021-10-26T12:00:00-04:00 2021-10-26T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Sean Harris Oct 26 Environmental Research Webinar
Department of Computational Medicine & Bioinformatics Weekly Seminar (October 27, 2021 4:00pm) https://events.umich.edu/event/88276 88276-21652019@events.umich.edu Event Begins: Wednesday, October 27, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:
Molecular classification has transformed the diagnosis and treatment of diffuse gliomas, creating targets for precision therapies. However, timely and efficient access to molecular diagnostic methods remains difficult, causing a significant barrier to deliver molecularly-targeted therapies. We aim to develop an innovative point-of-care diagnostic screening method that provides rapid and accurate molecular classification of diffuse gliomas through artificial intelligence and optical imaging in order to improve the comprehensive care of brain tumor patients.

Bio:
Dr. Todd Hollon is a neurosurgeon and research scientist who specializes in brain tumors. He is an Assistant Professor of Neurosurgery. He completed his postdoctoral training in the UM Translational Molecular Imaging Laboratory under the supervision of Drs. Daniel Orringer and Honglak Lee. His postdoctoral work focused on the application of deep neural networks to advanced imaging methods to improve the speed and accuracy of intraoperative brain tumor diagnosis. He hopes to be part of the next generation of young scientists that uses computation and machine learning to make scientific breakthroughs.

Host: Josh Welch, PhD

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

In-Person: Forum Hall, Palmer Commons

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Livestream / Virtual Thu, 14 Oct 2021 14:26:31 -0400 2021-10-27T16:00:00-04:00 2021-10-27T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual
DCM&B Tools and Technology Seminar (October 28, 2021 12:00pm) https://events.umich.edu/event/85361 85361-21626301@events.umich.edu Event Begins: Thursday, October 28, 2021 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

URL for remote viewing: https://umich-health.zoom.us/j/94886745590?pwd=LzhLU243K2ZhbXNzU1BJRHQ5V25BZz09

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Presentation Wed, 18 Aug 2021 09:46:40 -0400 2021-10-28T12:00:00-04:00 2021-10-28T13:00:00-04:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
“Disparities in Reproductive Aging & Midlife Health between Black & White Women” and “Taking Action to Advance the Study of Race & Ethnicity” (October 28, 2021 4:00pm) https://events.umich.edu/event/87494 87494-21642885@events.umich.edu Event Begins: Thursday, October 28, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for Midlife Science

Please register for more information and Zoom link.
https://umich.zoom.us/webinar/register/WN_JiZPRVJaStK7yNbArsSubA

The webinar, hosted by the Center for Midlife Science, features papers that will appear in a special series for the journal, Women's Midlife Health.

Talk #1 “Disparities in Reproductive Aging and Midlife Health between Black and White Women: Study of Women’s Health Across the Nation (SWAN)” with Tené T. Lewis, PhD, Department of Epidemiology, Emory University; and Siobán D. Harlow, PhD, Department of Epidemiology, University of Michigan.

Talk #2: “Taking Action to Advance the Study of Race and Ethnicity: The Women’s Health Initiative (WHI)” with Shawna Follis, PhD, MS (Dept. of Medicine, Stanford Univ. School of Medicine); Monik C. Jiménez, ScD, SM, FAHA, (Harvard Medical School and T.H. Chan School of Public Health); and Lorena Garcia, MPH, DrPH, (Division of Epidemiology, Dept. of Public Health Sciences, UC Davis School of Medicine).

Moderators: Sherri-Ann M. Burnett-Bowie, MD, MPH, Department of Medicine, Massachusetts General Hospital & Harvard Medical School; and Gloria Bachmann, MD, Rutgers Robert Wood Johnson Medical School.

Sponsored by the journal, Women’s Midlife Health; Center for Midlife Science at the University of Michigan's School of Public Health; Massachusetts General Hospital Department of Medicine Diversity and Inclusion Board. SWAN is funded by the National Institute of Aging, the National Institute of Nursing Research and the Office of Research on Women's Health. WHI is funded by the National Heart, Lung and Blood Institute.

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Lecture / Discussion Fri, 24 Sep 2021 12:04:41 -0400 2021-10-28T16:00:00-04:00 2021-10-28T17:00:00-04:00 Off Campus Location Center for Midlife Science Lecture / Discussion Webinar Series on Structural Racism and Midlife Health
Trans Medicine: The Emergence and Practice of Treating Gender (October 29, 2021 12:00pm) https://events.umich.edu/event/86703 86703-21635604@events.umich.edu Event Begins: Friday, October 29, 2021 12:00pm
Location: Off Campus Location
Organized By: Institute for Research on Women and Gender

Surfacing in the mid-twentieth century, yet shrouded in social stigma, transgender medicine is now a rapidly growing medical field. In Trans Medicine (NYU Press, 2021), stef shuster makes an important intervention in how we understand the development of this field and how it is being used to “treat” gender identity today.

Drawing on interviews with medical providers as well as ethnographic and archival research, shuster examines how health professionals approach patients who seek gender-affirming care. From genital reconstructions to hormone injections, the practice of trans medicine charts new medical ground, compelling medical professionals to plan treatments without widescale clinical trials to back them up. Relying on cultural norms and gut instincts to inform their treatment plans, shuster shows how medical providers’ lack of clinical experience and scientific research undermines their ability to interact with patients, craft treatment plans, and make medical decisions. This situation defies how providers are trained to work with patients and creates uncertainty. As providers navigate the developing knowledge surrounding the medical care of trans folk, Trans Medicine offers a rare opportunity to understand how providers make decisions while facing challenges to their expertise and, in the process, have acquired authority not only over clinical outcomes, but over gender itself.

stef m. shuster is Assistant Professor of Sociology at Michigan State University. Their work on transgender healthcare has appeared in Gender & Society, Journal of Health and Social Behavior, and Social Science & Medicine.

Register: https://myumi.ch/88rbx

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Livestream / Virtual Tue, 12 Oct 2021 11:42:01 -0400 2021-10-29T12:00:00-04:00 2021-10-29T13:00:00-04:00 Off Campus Location Institute for Research on Women and Gender Livestream / Virtual Trans Medicine
First Do No Harm: Understanding the ML/AI Behind Clinical Decision Alerts (October 29, 2021 1:00pm) https://events.umich.edu/event/87783 87783-21645946@events.umich.edu Event Begins: Friday, October 29, 2021 1:00pm
Location: Off Campus Location
Organized By: Precision Health

This is the second webinar in the Precision Health series "Demystifying the Data, Processes, and Tools that Are Changing Clinical Care."

Join us for an engaging introduction to machine learning (ML) and artificial intelligence (AI) in health care. Learn the limitations of using electronic health records (EHR) and the distinctions between AI, data science, ML, and informatics. Understand the role of AI, ML, data science, and informatics, how they work together to create clinical decision alerts, and implications on practice. Learn how these models move from development to deployment.

This webinar is geared toward clinicians from all health disciplines, ML/AI health care researchers, and anyone else interested in learning more about how connecting ML/AI with health care is changing clinical care.

**Please use @umich.edu (NOT @med.umich.edu) email to register.**

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Livestream / Virtual Fri, 01 Oct 2021 15:31:27 -0400 2021-10-29T13:00:00-04:00 2021-10-29T14:00:00-04:00 Off Campus Location Precision Health Livestream / Virtual Oct. 2021 Precision Health webinar
How Can We Make a Real Difference in Healthcare? The Challenges of Implementation (November 1, 2021 4:30pm) https://events.umich.edu/event/88632 88632-21656227@events.umich.edu Event Begins: Monday, November 1, 2021 4:30pm
Location: Industrial and Operations Engineering Building
Organized By: Center for Healthcare Engineering & Patient Safety (CHEPS)

Most of us who work in OR applications in healthcare are frustrated by the fact that planners, managers and decision makers do not seem to be suitably impressed with the mathematical beauty of our models. The literature abounds with hundreds of application papers; but when we take a closer look, few of them describe implementation. The problems in the healthcare industry are generally very similar to corresponding problems in any other sector. Hospitals have staffing issues, budget constraints, purchasing decisions, scheduling, planning, etc. The differences are subtle and often related to the culture. Over the years, I have encountered many challenges and I have been able to design approaches to deal with many of them. A few years ago, I was asked to pick the five top challenges. I can easily rattle off thirty, but selecting five was itself a challenge. In this talk, I will outline my perception of the major hurdles, provide a few examples and discuss strategies for overcoming them.

Michael Carter is a Professor in the Department of Mechanical and Industrial Engineering at the University of Toronto and Founding Director of the Centre for Healthcare Engineering (in 2009). Since 1989, his research focus has been in the area of health care resource modeling. He is on the editorial board for the journals “Health Care Management Science”, “Operations Research for Health Care”, “Health Systems” and “IISE Transactions on Healthcare Systems”. In 2012, he was inducted as a Fellow of the Canadian Academy of Engineering and in 2013, he was inducted as a Fellow of INFORMS, the international society for Operations Research and Management Science. In 2018, he became a Fellow of the Canadian Academy of Health Sciences. In 2019, he won the Northrup Frye Award for Teaching Excellence from the University of Toronto Alumni Association and in 2021, he was awarded the University of Toronto “President’s Impact Award” for his contributions to improving healthcare in Canada.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach. For the Zoom link and password and to be added to the weekly e-mail for the series, please RSVP. For additional questions, contact CHEPSseminar@umich.edu. Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Mon, 25 Oct 2021 15:17:49 -0400 2021-11-01T16:30:00-04:00 2021-11-01T17:30:00-04:00 Industrial and Operations Engineering Building Center for Healthcare Engineering & Patient Safety (CHEPS) Lecture / Discussion Michael W. Carter, Ph.D., LEL, FCAE
The Futurescape of Medicine Lecture Series (November 2, 2021 10:00am) https://events.umich.edu/event/85074 85074-21625548@events.umich.edu Event Begins: Tuesday, November 2, 2021 10:00am
Location: Off Campus Location
Organized By: Osher Lifelong Learning Institute (50+)

The goal of this lecture series is to provide educational insights about future developments in five different areas of medical care.

Lecture #4 - New Approaches to the Treatment of Gynecologic Cancers.
Our speakers will be Claire Friedman, MD and Alison Schram, MD.

Attention will be paid to current best practices, ethical implications of new technologies, promotion of consumer education and choices, and financial aspects of delivery in the context of value-based care. A lively discussion is anticipated for each lecture regarding the many issues raised by these trends and technologies.”

Preregistration is required via the OLLI website or phone. A link to access the lecture will be e-mailed prior to the event.

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Class / Instruction Tue, 10 Aug 2021 12:24:12 -0400 2021-11-02T10:00:00-04:00 2021-11-02T11:30:00-04:00 Off Campus Location Osher Lifelong Learning Institute (50+) Class / Instruction Futurescape of Medicine
Bayesian models for mercury effects on multiple outcomes in the Seychelles Child Development Study (November 2, 2021 12:00pm) https://events.umich.edu/event/88561 88561-21655084@events.umich.edu Event Begins: Tuesday, November 2, 2021 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Sally W. Thurston, PhD is an Associate Professor of Biostatistics and Environmental Medicine, University of Rochester, Dept of Biostatistics and Computational Biology.

ABSTRACT: The Seychelles Child Development Study (SCDS) Main Cohort was recruited to investigate the association between prenatal mercury (Hg) exposure from maternal fish consumption and the children’s subsequent development. Multiple neurodevelopmental outcomes were measured at several discrete ages. These outcomes can be grouped into different classes or "domains", such as cognition, motor, or memory. Associations of Hg and covariates may differ across outcomes and domains. Motivated by the SCDS, I will first discuss a model for multiple outcomes at a single age under the assumption that each outcome belongs to one domain and domain memberships are known. I will then briefly describe two extensions: a model in which outcomes may have partial domain membership in more than one domain, and a longitudinal multiple outcomes model for cognition when the tests of cognition change with the age of the child.

The goal of Environmental Statistics Week is to disseminate knowledge of advanced statistical methods most relevant to environmental health research with expert-led discussions on statistical concepts.

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Lecture / Discussion Fri, 22 Oct 2021 16:34:57 -0400 2021-11-02T12:00:00-04:00 2021-11-02T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion 2021 Environmental Statistics Week
Department of Computational Medicine & Bioinformatics Weekly Seminar (November 3, 2021 4:00pm) https://events.umich.edu/event/88449 88449-21654119@events.umich.edu Event Begins: Wednesday, November 3, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract
My research group works in the area of mathematical oncology, where we use mathematical models to decipher the complex networks of reactions inside of cancer cells and interactions between cells. Immune cells use hundreds of biochemical reactions to respond to their environment, become activated, and kill cancer cells. Understanding the complexity of these reaction networks requires computational tools and mathematical models. We combine detailed, mechanistic modeling with machine learning to study these networks, better understand cancer and immune cells, and predict ways to control tumor growth. In this talk, I will present our recent work aimed at predicting the dynamics of immune cell behaviors across three scales: intracellular signaling pathways in CAR T cells, the collective behavior of a heterogeneous population of immune cells, and tumor-immune interactions at the tissue scale. Our models generate novel mechanistic insight into immune cell activation and predict the effects of immunotherapeutic strategies.


Biography
Stacey D. Finley is the Gordon S. Marshall Early Career Chair and Associate Professor of Biomedical Engineering at the University of Southern California. Dr. Finley received her B.S. in Chemical Engineering from Florida A & M University and obtained her Ph.D. in Chemical Engineering from Northwestern University. She completed postdoctoral training at Johns Hopkins University in the Department of Biomedical Engineering. Dr. Finley joined the faculty at USC in 2013, and she leads the Computational Systems Biology Laboratory. Dr. Finley has joint appointments in the Departments of Chemical Engineering and Materials Science and Quantitative and Computational Biology, and she is a member of the USC Norris Comprehensive Cancer Center. Dr. Finley is also the Founding Director of the Center for Computational Modeling of Cancer at USC. Her research is supported by grants from NSF, NIH, and the American Cancer Society.

Selected honors. 2016 NSF Faculty Early CAREER Award; 2016 Young Innovator by the Cellular and Molecular Bioengineering journal; Leah Edelstein-Keshet Prize from the Society of Mathematical Biology; Junior Research Award from the USC Viterbi School of Engineering; the Hanna Reisler Mentorship Award; 2018 AACR NextGen Star; 2018 Orange County Engineering Council Outstanding Young Engineer; Elected Fellow of the American Institute for Medical and Biological Engineering (2021)

Hosted by: Alan Boyle, PhD

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Wed, 20 Oct 2021 09:54:50 -0400 2021-11-03T16:00:00-04:00 2021-11-03T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual Stacey D. Finley, Ph.D. (USC)
DCM&B Tools and Technology Seminar (November 4, 2021 12:00pm) https://events.umich.edu/event/85368 85368-21626321@events.umich.edu Event Begins: Thursday, November 4, 2021 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

URL for remote viewing: https://umich-health.zoom.us/j/94886745590?pwd=LzhLU243K2ZhbXNzU1BJRHQ5V25BZz09

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Presentation Wed, 18 Aug 2021 14:35:23 -0400 2021-11-04T12:00:00-04:00 2021-11-04T13:00:00-04:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
What do we learn from the environmental surveillance of SARS-CoV-2 on and off campus? (November 4, 2021 12:00pm) https://events.umich.edu/event/88563 88563-21655086@events.umich.edu Event Begins: Thursday, November 4, 2021 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Chuanwu Xi, PhD, is a Professor of Environmental Health Sciences and Global Public Health in the School of Public Health, University of Michigan.

The goal of Environmental Statistics Week is to disseminate knowledge of advanced statistical methods most relevant to environmental health research with expert-led discussions on statistical concepts.

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Lecture / Discussion Fri, 22 Oct 2021 16:48:21 -0400 2021-11-04T12:00:00-04:00 2021-11-04T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion 2021 Environmental Statistics Week
Precision Health Information Session (November 4, 2021 1:00pm) https://events.umich.edu/event/88483 88483-21654244@events.umich.edu Event Begins: Thursday, November 4, 2021 1:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

The growing field of precision health seeks to tailor health care for individuals via a multidisciplinary, data-driven approach.

The new U-M Precision Health Graduate Certificate Program has arrived to educate current and future practitioners and researchers in this emerging field so they can become better equipped to customize patient care.

• Only 12 credits of graduate coursework required
• Great opportunity for graduate students to design their own plan
• Network with other precision health students and faculty at seminars and professional development workshops
• Mentoring with faculty
• The certificate is open to all graduate students enrolled at U-M.

Attend an information session to learn more.

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Presentation Wed, 20 Oct 2021 16:17:31 -0400 2021-11-04T13:00:00-04:00 2021-11-04T13:30:00-04:00 Off Campus Location Department of Learning Health Sciences Presentation research scientist, healthcare professionals and students in lab, clinic and classroom settings