Happening @ Michigan https://events.umich.edu/list/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. 2021 BME Symposium (May 10, 2021 12:00pm) https://events.umich.edu/event/82858 82858-21203302@events.umich.edu Event Begins: Monday, May 10, 2021 12:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

To register please see:
https://myumi.ch/r8GzZ

The 2021 BME symposium will showcase our work in the areas of Imaging, Neural Engineering, Regenerative Medicine, and Precision Health. The event will take place over two days in the afternoons of Monday, May 10, 12:00 PM - 5:00 PM, and Tuesday, May 11, 12:00 PM - 5:00 PM. Each afternoon will include faculty talks, mini student dissertations, a panel discussion, and student poster sessions.

The goal of this event is to bring together faculty and students affiliated with BME from all parts of campus as a step toward building the BME community and celebrating accomplishments through difficult times while having an eye toward the future.

Please sign up and join us!

2021 U-M BME Symposium



May 10, 2021: 12:00 PM - 5:00 PM


Imaging at UM

May 10, 2021 - 12:00pm - 1:30pm
Location: Virtual/Zoom
Livestream Available (Visible After Registration)

Moderator: Doug Noll
12:00 - 12:15 - Zhongming Liu, “Preclinical MRI of brain-gut interactions”
12:15 - 12:30 - Nicole Seiberlich, “Translating Quantitative MRI to the Clinic”
12:30 - 12:45 - Yannis Paulus, “Multimodal Photoacoustic Microscopy, OCT, and Fluorescence Molecular and Cellular Imaging of the Retina”
12:45 - 1:05 - Student Dissertations
1:05 - 1:30 - Panel Discussion - “The Future of Imaging Research at Michigan” - Vikas Gulani, Jeff Fessler, Cheri Deng, Zhen Xu, Xueding Wang


Neural Engineering at UM

May 10, 2021 - 2:00pm - 3:30pm
Location: Virtual/Zoom
Livestream Available (Visible After Registration)

Moderator: Jim Weiland
2:00 - 2:15 - Kamran Diba, TBD
2:15 - 2:30 - Scott Lempka, TBD
2:30 - 2:45 - Deanna Gates, TBD
2:45 - 3:05 - Student Dissertations
3:05 - 3.30 - Panel Discussion - “The Science Fiction Future of Neural Engineering” - Cindy Chestek, Parag Patil, Tim Bruns, Bill Stacey


Poster Session: Imaging & Neural Engineering

May 10, 2021 - 4:00pm - 5:00pm
Location: Virtual/Spatial Chat

This poster session will give BME students a chance to present and discuss their research in the areas of Imaging and Neural Engineering.


May 11, 2021: 12:00 PM - 5:00 PM


Regenerative Medicine at UM

May 11, 2021 - 12:00pm - 1:30pm
Location: Virtual/Zoom
Livestream Available (Visible After Registration)

Moderator: Lonnie Shea
12:00 - 12:15 - Carlos Aguilar, ”Understanding & Re-Writing Stem Cell Programs to Live Forever.”
12:15 - 12:30 - Idse Heemskerk, “Predicting cell fate from signaling history in human pluripotent stem cells”
12:30 - 12:45 - Ariella Shikanov, TBD
12:45 - 1:05 - Student Dissertations
1:05 - 1:30 - Panel Discussion - "Grand Challenges in Regenerative Medicine" - Dave Kohn


Precision Health at UM

May 11, 2021 - 2:00pm - 3:30pm
Location: Virtual/Zoom
Livestream Available (Visible After Registration)

Moderator: TBD
2:00 - 2:15 - Sriram Chandrasekharan, TBD
2:15 - 2: 30 - James Moon, TBD
2:30 - 2:45 - Deepak Nagrath, TBD
2:45 - 3:05 - Student Dissertations
3:05 - 3:30 - Panel Discussion - "Hope or Hype for Treating Diseases" - James Moon, Sriram Chandrasekharan, Deepak Nagrath



Poster Session: Regenerative Medicine & Precision Health


May 11, 2021 - 4:00pm - 5:00pm
Location: Virtual/Spatial Chat


This poster session will give BME students a chance to present and discuss their research in the areas of Regenerative Medicine and Precision Health.

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Conference / Symposium Thu, 22 Apr 2021 13:38:37 -0400 2021-05-10T12:00:00-04:00 2021-05-10T17:00:00-04:00 Off Campus Location Biomedical Engineering Conference / Symposium BME Logo
From Medical Image to Icon: How Art Can Heal a Broken Body (May 10, 2021 12:00pm) https://events.umich.edu/event/83790 83790-21530352@events.umich.edu Event Begins: Monday, May 10, 2021 12:00pm
Location: Off Campus Location
Organized By: The University of Michigan Medical School Program on Health, Spirituality and Religion

Devan Stahl is an Assistant Professor of Bioethics in the Department of Religion at Baylor University. Her research interests include disability ethics, medicine and the visual arts, and theological bioethics. Dr. Stahl’s last book, Imaging and Imagining Illness: Becoming Whole in a Broken Body is an edited volume examining the power of medical images on the experience of chronic illness and disability.

Abstract: Many people will first learn they have an illness through a medical image such as an MRI, but these images often deny the messiness, ambiguities, and the identity of the patient who is represented in them. In this presentation, Devan Stahl explores how medical images have historically revealed the implicit theology of the culture in which they are produced. Today, a growing number of artists with disabilities are transforming their medical images into works of art, which raise deeply theological questions concerning what it means to be embodied and how our bodies relate to a transcendent God.

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Workshop / Seminar Mon, 19 Apr 2021 07:45:19 -0400 2021-05-10T12:00:00-04:00 2021-05-10T13:00:00-04:00 Off Campus Location The University of Michigan Medical School Program on Health, Spirituality and Religion Workshop / Seminar
2021 BME Symposium (May 11, 2021 12:00pm) https://events.umich.edu/event/82858 82858-21555869@events.umich.edu Event Begins: Tuesday, May 11, 2021 12:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

To register please see:
https://myumi.ch/r8GzZ

The 2021 BME symposium will showcase our work in the areas of Imaging, Neural Engineering, Regenerative Medicine, and Precision Health. The event will take place over two days in the afternoons of Monday, May 10, 12:00 PM - 5:00 PM, and Tuesday, May 11, 12:00 PM - 5:00 PM. Each afternoon will include faculty talks, mini student dissertations, a panel discussion, and student poster sessions.

The goal of this event is to bring together faculty and students affiliated with BME from all parts of campus as a step toward building the BME community and celebrating accomplishments through difficult times while having an eye toward the future.

Please sign up and join us!

2021 U-M BME Symposium



May 10, 2021: 12:00 PM - 5:00 PM


Imaging at UM

May 10, 2021 - 12:00pm - 1:30pm
Location: Virtual/Zoom
Livestream Available (Visible After Registration)

Moderator: Doug Noll
12:00 - 12:15 - Zhongming Liu, “Preclinical MRI of brain-gut interactions”
12:15 - 12:30 - Nicole Seiberlich, “Translating Quantitative MRI to the Clinic”
12:30 - 12:45 - Yannis Paulus, “Multimodal Photoacoustic Microscopy, OCT, and Fluorescence Molecular and Cellular Imaging of the Retina”
12:45 - 1:05 - Student Dissertations
1:05 - 1:30 - Panel Discussion - “The Future of Imaging Research at Michigan” - Vikas Gulani, Jeff Fessler, Cheri Deng, Zhen Xu, Xueding Wang


Neural Engineering at UM

May 10, 2021 - 2:00pm - 3:30pm
Location: Virtual/Zoom
Livestream Available (Visible After Registration)

Moderator: Jim Weiland
2:00 - 2:15 - Kamran Diba, TBD
2:15 - 2:30 - Scott Lempka, TBD
2:30 - 2:45 - Deanna Gates, TBD
2:45 - 3:05 - Student Dissertations
3:05 - 3.30 - Panel Discussion - “The Science Fiction Future of Neural Engineering” - Cindy Chestek, Parag Patil, Tim Bruns, Bill Stacey


Poster Session: Imaging & Neural Engineering

May 10, 2021 - 4:00pm - 5:00pm
Location: Virtual/Spatial Chat

This poster session will give BME students a chance to present and discuss their research in the areas of Imaging and Neural Engineering.


May 11, 2021: 12:00 PM - 5:00 PM


Regenerative Medicine at UM

May 11, 2021 - 12:00pm - 1:30pm
Location: Virtual/Zoom
Livestream Available (Visible After Registration)

Moderator: Lonnie Shea
12:00 - 12:15 - Carlos Aguilar, ”Understanding & Re-Writing Stem Cell Programs to Live Forever.”
12:15 - 12:30 - Idse Heemskerk, “Predicting cell fate from signaling history in human pluripotent stem cells”
12:30 - 12:45 - Ariella Shikanov, TBD
12:45 - 1:05 - Student Dissertations
1:05 - 1:30 - Panel Discussion - "Grand Challenges in Regenerative Medicine" - Dave Kohn


Precision Health at UM

May 11, 2021 - 2:00pm - 3:30pm
Location: Virtual/Zoom
Livestream Available (Visible After Registration)

Moderator: TBD
2:00 - 2:15 - Sriram Chandrasekharan, TBD
2:15 - 2: 30 - James Moon, TBD
2:30 - 2:45 - Deepak Nagrath, TBD
2:45 - 3:05 - Student Dissertations
3:05 - 3:30 - Panel Discussion - "Hope or Hype for Treating Diseases" - James Moon, Sriram Chandrasekharan, Deepak Nagrath



Poster Session: Regenerative Medicine & Precision Health


May 11, 2021 - 4:00pm - 5:00pm
Location: Virtual/Spatial Chat


This poster session will give BME students a chance to present and discuss their research in the areas of Regenerative Medicine and Precision Health.

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Conference / Symposium Thu, 22 Apr 2021 13:38:37 -0400 2021-05-11T12:00:00-04:00 2021-05-11T17:00:00-04:00 Off Campus Location Biomedical Engineering Conference / Symposium BME Logo
Connecting Education Innovation to Activism (May 12, 2021 12:00pm) https://events.umich.edu/event/83807 83807-21538170@events.umich.edu Event Begins: Wednesday, May 12, 2021 12:00pm
Location: Off Campus Location
Organized By: RISE (Research. Innovation. Scholarship. Education.)

R.I.S.E., the Center for Academic Innovation, and the Center for Research on Learning & Teaching (CRLT) invite you to join a Virtual Talking Circle (VTC) to discuss unique connections between education innovation & activism.

This collaboration across the University will serve as a first step in building a community interested in designing and promoting education innovation to improve society.

Anyone interested in education innovation and/or social justice and activism is invited!  We want to learn who is already doing this important work and identify potential collaborations across the University.

Please join us on Wednesday, May 12, 2021 from 12:00 - 1:00 PM

Register via Eventbrite

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Workshop / Seminar Tue, 20 Apr 2021 06:37:52 -0400 2021-05-12T12:00:00-04:00 2021-05-12T13:00:00-04:00 Off Campus Location RISE (Research. Innovation. Scholarship. Education.) Workshop / Seminar RISE Virtual Talking Circle
RNA Seminar featuring: Thomas Martinez, Salk Institute for Biological Studies (May 17, 2021 4:00pm) https://events.umich.edu/event/81303 81303-20881903@events.umich.edu Event Begins: Monday, May 17, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

Registration Required: https://umich.zoom.us/webinar/register/WN_90RkcQTGQZa7ifQ8kbSdNQ

KEYOWORDS: microprotein, smORF, ribosome profiling

ABSTRACT: Functional protein-coding small open reading frames (smORFs) are emerging as an important class of genes. Several smORF-encoded microproteins have been characterized and implicated in a variety of critical processes, including regulation of mRNA decay, DNA repair, and muscle formation. Thus, rigorous and comprehensive annotation of protein-coding smORFs is critical to our understanding of basic biology and physiology, as well as disease. We recently developed an improved workflow that integrates de novo transcriptome assembly and ribosome profiling to overcome obstacles with previous methods to more confidently annotate thousands of novel smORFs across multiple human cell lines, including hundreds encoded on putative non-coding RNAs. Over 1,500 smORFs are found in two or more cell lines, and ~40% lack a canonical AUG start codon. Evolutionary conservation analyses suggest that hundreds of smORF-encoded microproteins are likely functional. We also find that smORF-derived peptides are detectable on human leukocyte antigen complexes, positioning smORFs as a source of novel antigens. The annotation of protein-coding smORFs radically alters the current view of the human genome’s coding capacity and will provide a rich pool of unexplored, functional human genes.

BIO: Thomas received his B.S. in Biological Engineering from MIT and trained in Prof. JoAnne Stubbe’s laboratory, where he studied the mechanism of ribonucleotide reductase. He then recieved his Ph.D. in Biochemistry & Molecular Biophysics from Caltech as an NIH NRSA predoctoral fellow under the mentorship of Prof. Peter Dervan. His thesis work focused primarily on characterizing the effects of DNA binding pyrrole-imidazole polyamides on DNA replication in prostate cancer cells. Thomas is currently an NIH NRSA postdoctoral fellow in Prof. Alan Saghatelian’s laboratory, where he has developed an integrative platform combining ribosome profiling and de novo transcriptome assembly to discover functional smORF encoded microproteins in the human genome.

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Lecture / Discussion Wed, 14 Apr 2021 12:39:54 -0400 2021-05-17T16:00:00-04:00 2021-05-17T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Thomas Martinez, Salk Institute for Biological Studies
Health Care Reform: A Conversation with the Experts (May 20, 2021 12:00pm) https://events.umich.edu/event/84008 84008-21619391@events.umich.edu Event Begins: Thursday, May 20, 2021 12:00pm
Location: Off Campus Location
Organized By: Institute for Healthcare Policy and Innovation

Where do we stand with the Affordable Care Act and its latest U.S. Supreme Court challenge? What health care reform policies might we expect from President Joe Biden and the new Congress?

Join the U-M Institute for Healthcare Policy and Innovation as we take on these questions and more. Our experts will discuss the legal, economic, medical, and health equity challenges related to health care reform now — and into the future.

IHPI Director John Ayanian, M.D., M.P.P., moderates an expert panel discussion featuring:

Helen G. Levy, Ph.D.
Research Professor, Institute for Social Research

Minal R. Patel, Ph.D., MPH
Associate Professor of Health Behavior and Health Education, School of Public Health

Nicholas Bagley, J.D.
Professor of Law, Law School

Visit https://ihpi.umich.edu/informing-policy/healthcare-reform to learn more about IHPI members’ research on the impact of health care reform.

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Livestream / Virtual Tue, 11 May 2021 08:48:28 -0400 2021-05-20T12:00:00-04:00 2021-05-20T13:00:00-04:00 Off Campus Location Institute for Healthcare Policy and Innovation Livestream / Virtual US Capitol building
Crucial Conversations: Mental Health Awareness (May 24, 2021 12:00pm) https://events.umich.edu/event/84010 84010-21619394@events.umich.edu Event Begins: Monday, May 24, 2021 12:00pm
Location: Off Campus Location
Organized By: Public Engagement & Impact

Millions of Americans face the reality of living with a mental illness, and there are many facets of mental health impacting numerous aspects of life. During Mental Health Awareness Month and beyond, the University of Michigan is committed to increasing knowledge, reducing stigma, and fostering a supportive community.

Join this engaging live conversation with U-M experts on prioritizing mental health, educating and advocating for resources and policies, and creating an uplifting environment for yourself and those around you. Researchers from Michigan Medicine, the School of Public Health, the Depression Center, and the Department of Psychology will share their insights, advice, and tools for our community members.

Moderator:
Preeti Malani, MD, MSJ, Chief Health Officer and a Professor of Medicine in the Division of Infectious Diseases

Panelists:
Ramaswami Mahalingam, PhD, Professor of Psychology and Director of the Mindful Dignity Lab

Michelle Riba, MD, MS, Clinical Professor, Department of Psychiatry and a member of the Eisenberg Family Depression Center

John Piette, PhD, Professor in Health Behavior and Health Education and Director of the Center for Managing Chronic Disease

Caitlan DeVries, Masters of Public Health student

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Livestream / Virtual Thu, 20 May 2021 10:25:14 -0400 2021-05-24T12:00:00-04:00 2021-05-24T13:00:00-04:00 Off Campus Location Public Engagement & Impact Livestream / Virtual Crucial Conversations: Mental Health Awareness
Precision Health Webinar (May 25, 2021 1:00pm) https://events.umich.edu/event/83924 83924-21617135@events.umich.edu Event Begins: Tuesday, May 25, 2021 1:00pm
Location: Off Campus Location
Organized By: Precision Health

Precision Health at the University of Michigan (U-M) invites you to engage with two outstanding Scholars who have been funded by Precision Health to develop their research.
Arun Subramaniyan, BE, MS (graduate student, College of Engineering): “Hardware-accelerated systems for next-generation sequencing analysis”

Alyse Krausz, BS, MS (graduate student research assistant, Biomedical Engineering): “A Point-of-Care Microfluidic System for Traumatic Brain Injury Diagnosis and Prognosis”

You'll hear more about their work and how they used Precision Health resources in these innovative projects.

**Please register to attend. We will send a link to the virtual presentation a few days in advance. We hope you'll join us!**

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Livestream / Virtual Tue, 04 May 2021 13:45:53 -0400 2021-05-25T13:00:00-04:00 2021-05-25T14:00:00-04:00 Off Campus Location Precision Health Livestream / Virtual May 2021 PH Webinar
Clinical Simulation Center Brown Bag Discussion (May 25, 2021 3:00pm) https://events.umich.edu/event/84097 84097-21620331@events.umich.edu Event Begins: Tuesday, May 25, 2021 3:00pm
Location:
Organized By: Department of Learning Health Sciences

"Omni II Infant, Safe Patient Handling Obesity suit, UH Training Room and Juno-Med fidelity manikin"

Our team is planning four short lightning talks, highlighting some new equipment and additions to our courses.

This will be a Zoom meeting.
https://umich.zoom.us/j/97929340876

Dial by your location
+1 646 876 9923
Meeting ID: 979 2934 0876

Find your local number: https://umich.zoom.us/u/ac04eNX6TC

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Lecture / Discussion Tue, 25 May 2021 15:21:30 -0400 2021-05-25T15:00:00-04:00 2021-05-25T16:00:00-04:00 Department of Learning Health Sciences Lecture / Discussion Mod CCO, DLHS Clinical Simulation Center
PhD Defense: Edward Peter Washabaugh IV (May 27, 2021 10:00am) https://events.umich.edu/event/84050 84050-21619709@events.umich.edu Event Begins: Thursday, May 27, 2021 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

Injuries to the neuromusculoskeletal systems often result in muscle weakness, abnormal coordination strategies, and gait impairments. Functional resistance training during walking—where a patient walks while a device increases loading on the leg—is an emerging approach to combat these symptoms. While simple passive devices (i.e., ankle weights and resistance bands) can be applied for this training, rehabilitation robots have more potential upside because they can be controlled to treat multiple gait abnormalities and can be monitored by clinicians. However, the cost of conventional robotic devices limits their use in the clinical or home setting. Hence, in this dissertation, we designed, developed, and tested passive and semi-passive wearable exoskeleton devices as a low-cost solution for providing controllable/configurable functional resistance training during walking.


We developed and tested two passive exoskeleton devices for providing resistance to walking and tested their effects on able-bodied participants and stroke survivors. First, we created a patented device that used a passive magnetic brake to provide a viscous (i.e., velocity-dependent) resistance to the knee. The resistive properties of the device could be placed under computer control (i.e., made semi-passive) to control resistance in real-time. Next, we created a passive exoskeleton that provided an elastic (i.e., position-dependent) resistance. While not controllable, this device was highly configurable. Meaning it could be used to provide resistance to joint flexion, extension, or to both (i.e., bidirectionally). Human subjects testing with these devices indicated they increased lower-extremity joint moments, powers, and muscle activation during training. Training also resulted in significant aftereffects—a potential indicator of therapeutic effectiveness—once the resistance was removed. A separate experiment indicated that individuals often kinematically slack (i.e., reduce joint excursions to minimize effort) when resistance is added to the limb. We also found that providing visual feedback of joint angles during training significantly increased muscle activation and kinematic aftereffects (i.e., reduced slacking).


With passive devices, the type of passive element used largely dictates the muscle groups, types of muscle contraction, joint actions, and the phases of gait when a device is able to apply resistance. To examine this issue, we compared the training effects of viscous and elastic devices that provided bidirectional resistance to the knee during gait. Additionally, we compared training with viscous resistances at the hip and knee joints. While the resistance type and targeted joint altered moments, powers, and muscle activation patterns, these methods did not differ in their ability to produce aftereffects, alter neural excitability, or induce fatigue in the leg muscles. While this may indicate that the resistance type does not have a large effect on functional resistance training during walking, it is possible that an extended training with these devices could produce a different result.


Lastly, we used musculoskeletal modeling in OpenSim to directly compare several strategies that have been used to provide functional resistance training to gait in the clinic or laboratory setting. We found that devices differed in their ability to alter gait parameters during walking. Hence, these findings could help clinicians when selecting a resistive strategy for their patients, or engineers when designing new devices or control schemes.



Date: Thursday, May 27, 2021

Time: 10:00 AM

Zoom: https://umich.zoom.us/meeting/register/tJIufumrrDgtHd3z5Jg3Y_BG4ZC70OPrjTjk (Zoom link requires prior registration)

Chair: Dr. Chandramouli Krishnan

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Lecture / Discussion Fri, 14 May 2021 13:49:26 -0400 2021-05-27T10:00:00-04:00 2021-05-27T11:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Getting Engaged in Campus Education Innovation Activities (June 9, 2021 12:00pm) https://events.umich.edu/event/84084 84084-21619928@events.umich.edu Event Begins: Wednesday, June 9, 2021 12:00pm
Location: Off Campus Location
Organized By: RISE (Research. Innovation. Scholarship. Education.)

Our next Virtual Talking Circle (VTC) will feature representatives from several units on campus that are leading the way in cultivating education innovation: The Center for Academic Innovation (CAI), Fast Forward Medical Innovation (FFMI), and the International Mixed Reality Grand Rounds.

Join us on Wednesday, June 9, 2021 from 12:00 - 1:00 PM to learn more about these units and how you can get involved in their education innovation activities. We hope you will also share other education innovation resources available to faculty, staff and learners.

All are welcome!

Register via Zoom at: https://umich.zoom.us/webinar/register/WN_xVYKDuaYSXa6AevHutqXBA

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Workshop / Seminar Thu, 20 May 2021 06:44:41 -0400 2021-06-09T12:00:00-04:00 2021-06-09T13:00:00-04:00 Off Campus Location RISE (Research. Innovation. Scholarship. Education.) Workshop / Seminar RISE Virtual Talking Circle
RNA Innovation Seminar featuring Rising Scholars: Khan & McMillan (June 14, 2021 4:00pm) https://events.umich.edu/event/83934 83934-21619166@events.umich.edu Event Begins: Monday, June 14, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

Registration Required: https://umich.zoom.us/webinar/register/WN_uLz-ONHVQPuRINMYUNvBJQ

“CCR5 as a model to examine reporter assays in evaluating translational phenomena”
Yousuf Khan
Knight-Hennessy Scholar
Stanford University

KEYWORDS: dual luciferase, frameshifting, recoding, CCR5
ABSTRACT: During the decoding of a subset of mRNAs, a proportion of ribosomes productively shift to the −1 reading frame at specific slippage-prone sites in a phenomenon known as programmed −1 ribosomal frameshifting (−1 PRF) to generate a frameshifted, C-terminally unique protein. The first experimentally verified occurrence of functionally utilized non-retroelement derived −1 PRF in humans has been reported in the mRNA encoding the immune-functioning C-C chemokine receptor 5 (CCR5). Here, we show that frameshifting does not occur during CCR5 decoding. Apart from its importance in understanding expression of a gene relevant to cancer, an HIV-1 receptor (and the associated claimed rationale for generating the first humans derived from genetically modified embryos), the findings imply that caution is appropriate in assessing results from translational reporter assays.

~and~

“Intersection between RNA methylation and TDP43-mediated toxicity in ALS”
Michael McMillan
Ph.D. candidate
Cellular and Molecular Biology
University of Michigan

KEYWORDS: TDP43, m6A, ALS, RNA stability
ABSTRACT: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease resulting in the death of upper and lower motor neurons. ALS has no known cure and limited therapeutic options, and the underlying pathological mechanisms remain unclear. Despite considerable variability in clinical presentation, over 95% of ALS cases exhibit cytoplasmic inclusions of the RNA binding protein TDP43. Emerging evidence suggests that TDP43 is crucial for RNA stability, and that dysregulation of RNA homeostasis may contribute to ALS pathogenesis.
Methylation of RNA at the 6th position nitrogen (N6-methyladenosine methylation, or m6A) by methyltransferases (writers) or removal of methyl groups by demethylases (erasers) has dramatic effects on RNA stability and translation mediated by a family of RNA biding proteins that recognize methylated RNA (readers). m6A writers and erasers specifically localize to nuclear speckles, membraneless nuclear organelles rich in RNA binding proteins and splicing factors, including TDP43. Together with our data showing that TDP43 regulates RNA stability, these observations suggest that TDP43 may destabilize m6A modified RNA. Here, we show that methylated RNA co-purified with TDP43 from cultured cells via RNA immunoprecipitation, and abrogation of methylation sites disrupted TDP43 binding, suggesting that TDP43 recognizes m6A modified RNA in cellulo. We also noted profound and widespread hypermethylation of coding and non-coding transcripts in ALS spinal cord, many overlapping with confirmed TDP43 target transcripts. Consistent with a central role for m6A modification in TDP43-mediated toxicity, we identified several factors operating within the m6A pathway that enhance or suppress the toxicity of TDP43 in rodent primary cortical neurons via a single-cell CRISPR/Cas9 candidate-based screen. Genetic knockout of the established m6A reader YTHDF2 rescued TDP43 toxicity in primary neurons, and YTHDF2 was also upregulated in ALS postmortem sections. Together, these data imply a fundamental link between m6A RNA modifications and ALS pathogenesis, potentially mediated by TDP43-dependent RNA destabilization.

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Lecture / Discussion Tue, 18 May 2021 14:31:45 -0400 2021-06-14T16:00:00-04:00 2021-06-14T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Yousuf Khan (Stanford) & Mike McMillan (U-M)
Clinical Simulation Center Brown Bag Discussion (June 15, 2021 12:00pm) https://events.umich.edu/event/84097 84097-21620084@events.umich.edu Event Begins: Tuesday, June 15, 2021 12:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

"Omni II Infant, Safe Patient Handling Obesity suit, UH Training Room and Juno-Med fidelity manikin"

Our team is planning four short lightning talks, highlighting some new equipment and additions to our courses.

This will be a Zoom meeting.
https://umich.zoom.us/j/97929340876

Dial by your location
+1 646 876 9923
Meeting ID: 979 2934 0876

Find your local number: https://umich.zoom.us/u/ac04eNX6TC

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Lecture / Discussion Tue, 25 May 2021 15:21:30 -0400 2021-06-15T12:00:00-04:00 2021-06-15T13:00:00-04:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion Mod CCO, DLHS Clinical Simulation Center
Precision Health Graduate Certificate Program - Information Session (June 17, 2021 1:00pm) https://events.umich.edu/event/84199 84199-21620752@events.umich.edu Event Begins: Thursday, June 17, 2021 1:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Plan to attend this information session to learn more about the growing field of precision health which seeks to tailor health care for individuals via a multidisciplinary, data-driven approach.

The new U-M Precision Health Graduate Certificate Program has arrived to educate current and future practitioners and researchers in this emerging field so they can become better equipped to customize patient care.

**Only 12 credits of graduate coursework required
**Great opportunity for graduate students to design their own plan
**Network with other precision health students and faculty at seminars and professional development workshops
**Mentoring with faculty

The certificate is open to all graduate students enrolled at U-M. Application deadline is August 1.

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Other Thu, 03 Jun 2021 10:50:45 -0400 2021-06-17T13:00:00-04:00 2021-06-17T13:30:00-04:00 Off Campus Location Department of Learning Health Sciences Other learners and researchers in lab, classroom and research settings
Personal Statements 101: Let's Talk Shop (June 22, 2021 9:00am) https://events.umich.edu/event/84093 84093-21620026@events.umich.edu Event Begins: Tuesday, June 22, 2021 9:00am
Location: Off Campus Location
Organized By: Writing Consulting at Newnan

Meet the Newnan Writing Consultants, and invited specialized advisors, for general advice on framing and drafting your personal statement. While we will be unable to review individual writing at this session, you will be able to pose your questions and concerns (anonymously, if you wish), to the group, regarding personal statements for graduate, medical or law schools. For next steps, students will be directed to other resources and personal statement support on campus.

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Livestream / Virtual Tue, 08 Jun 2021 15:01:33 -0400 2021-06-22T09:00:00-04:00 2021-06-22T10:00:00-04:00 Off Campus Location Writing Consulting at Newnan Livestream / Virtual reflect_mirror_stick_fig
PhD Defense: Jiayue Cao (June 23, 2021 3:00pm) https://events.umich.edu/event/84287 84287-21621035@events.umich.edu Event Begins: Wednesday, June 23, 2021 3:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

The stomach and brain interact closely with each other. Their interactions are central to digestive functions and the “gut feeling”. The neural pathways that mediate the stomach-brain interactions include the vagus nerve and the thoracic nerve. Through these nerves, the stomach can relay neural signals to a number of brain regions that span a central gastric network. This gastric network allows the brain to monitor and regulate gastric physiology and allows the stomach to influence emotion and cognition. Impairment of this gastric network may lead to both gastric and neurological disorders, e.g., anxiety, gastroparesis, functional dyspepsia, and obesity. However, the structural constituents and functional roles of the central gastric network remain unclear. In my dissertation research, I leveraged complementary techniques to characterize the central gastric network in rats across a wide range of scales and different gastric states. In animal experiments, I used functional magnetic resonance imaging (fMRI) to map brain activity synchronized with gastric electrical activity and to map brain activations induced by electrical stimulation applied to the cervical vagus or its afferent terminals on the stomach. I also used neurophysiology to characterize gastric neurons in brainstem in response to gastric electrical stimulation. Results from my studies suggest that 1) gastric neurons in the brainstem are selective to the orientation of muscle activity relayed through intramuscular arrays, 2) the central gastric network is intrinsically coupled to gastric slow waves and their amplitude fluctuations primarily via vagal signaling, 3) selective stimulation of the vagus can evoke widespread and fast brain responses and alter functional connectivity within and beyond the central gastric network. My dissertation research contributes to the foundation of mapping and characterizing the central and peripheral mechanisms of gastric interoception and sheds new light on where and how to stimulate the peripheral nerves to modulate stomach-brain interactions.



Date: Wednesday, June 23, 2021

Time: 3:00 PM

Zoom: https://umich.zoom.us/j/2757414653

Chair: Dr. Zhongming Liu

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Lecture / Discussion Tue, 15 Jun 2021 23:04:33 -0400 2021-06-23T15:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
PhD Defense: Eric Charles Hobson (June 24, 2021 10:30am) https://events.umich.edu/event/84237 84237-21620794@events.umich.edu Event Begins: Thursday, June 24, 2021 10:30am
Location: Off Campus Location
Organized By: Biomedical Engineering

Mechanical testing of viscoelastic biomaterials is of critical importance in biomedical engineering, enabling basic research into the role of the extracellular matrix, investigatory and diagnostic testing of tissues and biofluids, and the development and characterization of tissue engineered therapeutics. Conventional material testing approaches used for soft biomaterials generally require force application through direct contact with a sample, leading to potential contamination and damage, and thereby limiting these approaches to end-point measurements. To overcome these limitations, we have developed a new measurement technique, Resonant Acoustic Rheometry (RAR), which enables high-throughput, quantitative, and non-contact viscoelastic characterization of biomaterials, soft tissues, and biological fluids.



RAR uses ultrasonic pulses to both generate microscale perturbations and measure the resulting resonant oscillations at the surface of soft materials using standard labware. Resonant oscillatory properties obtained from the frequency spectra of the surface oscillations, including the resonant frequency and the damping coefficient, are used to quantify material properties such as shear modulus, shear viscosity, and surface tension in both viscoelastic solids and liquids.



We developed a prototype RAR system and tested it on a range of soft biomaterials, with shear moduli ranging from under 100 Pa to over 50 kPa, including fibrin, gelatin, and polyethylene glycol (PEG). Shear moduli measured using RAR were validated both computationally using finite element analysis and experimentally using conventional shear rheometry, with excellent linear correlation in measured elasticity between techniques (R2 > 0.95). By performing parallel RAR experiments using microwells of different sizes, we verified that resonant oscillatory behaviors could be used to quantify the intrinsic viscoelastic properties of a material. We also demonstrated the rapid, non-contact monitoring of changes in material properties over a variety of temporal scales, ranging from processes occurring on the order of milliseconds to those occurring over hours and days. High temporal resolution RAR measurements, with sampling intervals as low as 0.2 seconds, were used to characterize the gelation process. Characteristic features of the resonant surface waves during phase transition were applied to identify the gel point for various hydrogels. High sample throughput was demonstrated by performing longitudinal RAR testing to explore the impact of hydrogel polymer and crosslinker concentration on both reaction kinetics and final mechanical properties in full factorial experiments consisting of over 15,000 unique measurements. We were able to identify individual effects of design parameters as well as interactions that led to unexpected mechanical properties, demonstrating the importance of combinatorial methods and high-throughput mechanical characterization in material design.



These studies demonstrate that RAR can rapidly and accurately assess the mechanical properties of soft viscoelastic biomaterials. The measurements generated are analogous to those produced using conventional mechanical testing, and RAR is further capable of longitudinal viscoelastic studies over time. RAR applies automation in both data collection and analysis, allowing high throughput measurement of an array of samples without contact or the need for manual intervention. Furthermore, RAR uses standard microwell plates, which simplifies sample preparation and handling. The viscoelastic properties of soft biomaterials are relevant in a wide range of applications, including for clinical diagnostic assays and the development of hydrogel materials for regenerative medicine. RAR represents a fast, accurate, and cost-effective method for materials characterization in these applications.



June 24 - 10:30 AM

Zoom: https://umich.zoom.us/meeting/register/tJcsd-iurTosGdNn_gR-FbOCe5TUR09Y58WV

Co-Chairs: Dr. Cheri Deng and Dr. Jan Stegmann

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Lecture / Discussion Tue, 22 Jun 2021 16:37:33 -0400 2021-06-24T10:30:00-04:00 2021-06-24T11:30:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
LHS Collaboratory-Summer Workshop (June 24, 2021 1:00pm) https://events.umich.edu/event/83809 83809-21538171@events.umich.edu Event Begins: Thursday, June 24, 2021 1:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

This virtual workshop will review the basic concepts behind Learning Health Systems including the learning cycle, infrastructure, and learning communities.  Participants will engage in a collaborative activity to design a learning cycle.

Registration for this virtual event is limited-
please register early!

Charles P. Friedman

Department Chair of Learning Health Sciences
Josiah Macy Jr. Professor of Medical Education
Professor of Information
Professor of Public Health
University of Michigan

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Workshop / Seminar Tue, 20 Apr 2021 10:17:48 -0400 2021-06-24T13:00:00-04:00 2021-06-24T16:00:00-04:00 Off Campus Location Department of Learning Health Sciences Workshop / Seminar LHS Collaboratory logo
BME Master's Defense: Spencer Morris (June 28, 2021 10:00am) https://events.umich.edu/event/84342 84342-21623372@events.umich.edu Event Begins: Monday, June 28, 2021 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

Acquiring accurate measurements for blood flow is a clinically relevant problem of interest. Three-dimensional color flow with partial volume correction (PVC) is a relatively new method for measuring blood flow that accounts for beams located partially outside of the blood vessel. Recent work has shown that the relationship between color flow power and partially perfused voxels is nonlinear. This work investigates the statistics of color power measurements in simulated plug flow to help explain this nonlinear behavior. Data was acquired using Field II simulations in which a 3.75 MHz mechanically swept linear array obtained RF data of blood moving through a vessel. Blood in the vessel exhibited plug flow, and tissue backscatter was set to 40 dB below blood. The statistics of color power at each point in the processing chain were analyzed using histograms, established results in ultrasound statistics, and derived probability density functions (pdfs). For locations completely inside the beam, power before additional processing showed exponential behavior, whereas the square root of power, i.e., amplitude, was Rician distributed. After implementing the Kasai algorithm, the power values could be estimated with a gamma distribution with a shape parameter of 2.21. Kasai powers corresponding to tissue could also be fitted with a gamma distribution, albeit with a shape parameter close to 1, indicating close to exponential behavior. Kasai powers for partial volume data were intermediate between the tissue and blood data. A method for estimating partial volume weight from the skewness and kurtosis of samples taken from the same location is also discussed.

Date: Monday, June 28, 2021
Time: 10:00 AM
Zoom: https://umich.zoom.us/j/97162930417
Chair: Dr. Oliver Kripfgans

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Presentation Tue, 22 Jun 2021 11:48:21 -0400 2021-06-28T10:00:00-04:00 2021-06-28T11:00:00-04:00 Off Campus Location Biomedical Engineering Presentation BME Event
RNA Collaborative Seminar (June 30, 2021 4:00pm) https://events.umich.edu/event/84166 84166-21620522@events.umich.edu Event Begins: Wednesday, June 30, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_6OEQ6sDAQ0-21GHm6d7VEQ

“Dynamic multivalent interactions drive mammalian RNA regulation”
Sethu Pitchiaya, Ph.D.
Dept of Urology

and

"Characterizing cellular RNA-protein interaction networks with chemical probes"
Chase Weidmann, Ph.D.
Dept of Biological Chemistry

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Lecture / Discussion Wed, 09 Jun 2021 15:28:29 -0400 2021-06-30T16:00:00-04:00 2021-06-30T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Sethu Pitchiaya & Chase Weidmann
Examining the Risk of Potentially Preventable Hospitalization in Adults with Congenital and Acquired Disabilities (July 8, 2021 2:00pm) https://events.umich.edu/event/84312 84312-21623271@events.umich.edu Event Begins: Thursday, July 8, 2021 2:00pm
Location: Off Campus Location
Organized By: Inter-university Consortium for Political and Social Research

Link to registration: https://umich.zoom.us/webinar/register/WN_0EcJEoE7QP-KtRCtxJnRqw

Adults with pediatric-onset (cerebral palsy/spina bifida (CP/SB)) or acquired disabilities (spinal cord injury (SCI) or multiple sclerosis (MS)) are more likely than those without disability to develop medical complications. Little is known about potentially preventable hospitalizations (PPH) among adults with disabilities. PPHs are preventable if a patient had timely access to care. The objective of this study was to examine potential risk and protective factors for PPH, comparing adults with aforementioned disabilities to people without. Our results indicate that adults with disabilities were at greater odds for PPH compared to people without disabilities. Use of preventative services such as annual wellness visit had substantial protective association against PPH. Attendees will learn: (1) how to work with administrative claims data and medical codes to identify appropriate case and control groups; (2) how to define covariates and outcome measures in claims data; (3) how to use various modeling techniques to test a hypothesis; (4) how to interpret the results and develop policy implications.

This webinar is free and open to the public. Communication Access Realtime Translation services will be available to provide live closed captions for the event.

The content of this webinar has been developed under a grant from the National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR #90RTHF0001). NIDILRR is a Center within the Administration for Community Living (ACL), Department of Health and Human Services (HHS). The contents of this webinar do not necessarily represent the policy of NIDILRR, ACL, or HHS and you should not assume endorsement by the Federal Government.

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Presentation Thu, 17 Jun 2021 18:07:45 -0400 2021-07-08T14:00:00-04:00 2021-07-08T15:00:00-04:00 Off Campus Location Inter-university Consortium for Political and Social Research Presentation IDEAL RRTC July 8 2021 Webinar
PhD Defense: Hans Zander (July 9, 2021 9:00am) https://events.umich.edu/event/84346 84346-21623406@events.umich.edu Event Begins: Friday, July 9, 2021 9:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

Spinal cord stimulation (SCS) is a neuromodulation technique that applies electrical stimulation to the spinal cord to alter neural activity or processing. While SCS has historically been used as a last resort therapy for chronic pain management, novel applications and technologies have recently been developed that either increase the efficacy of treatment for chronic pain or drive neural activity to produce muscular activity/movement following a paralyzing spinal cord injury (SCI). Despite these recent innovations, there remain fundamental questions concerning the neural recruitment underlying these efficacious results. This work evaluated the neural activity and mechanisms for two novel SCS applications: closed-loop spinal cord stimulation for pain management, and ventral, high frequency spinal cord stimulation (HF-SCS) for inspiratory muscle activation following a SCI.

To evaluate neural activity, I developed computational models of SCS. Models consisted of 3 components: a finite element model (FEM) of the spinal cord to predict voltages during stimulation, biophysical neuron models, and algorithms to apply time-dependent extracellular voltages to the neuron models and simulate their response. While this cutting-edge modeling methodology could be used to predict neural activity following stimulation, it was unclear how common anatomical or technical model simplifications affected neural predictions. Therefore, the initial goal of this work was to evaluate how modeling assumptions influence neural behavior.

My initial work identified how several relevant anatomical and technical factors influence model predictions of neural activity. To evaluate these factors, I designed an FEM of a T9 thoracic spine with an implanted electrode. Then, I sequentially removed details from the model and quantified the changes in neural predictions. I identified several factors with profound (>30%) impacts on neural thresholds, including overall model impedance (for voltage-controlled stimulation), the presence of a detailed vertebral column, and dura mater conductivity. I also identified several factors that could safely be ignored in future models. This work will be invaluable as a guide for future model development.

Next, I developed a canine model to evaluate T2 ventral HF-SCS for inspiratory muscle activation. I designed and positioned two neuron models hypothesized to lead to inspiratory behavior: ventrolateral funiculus fibers (VLF) leading to diaphragm activation and inspiratory intercostal motoneurons. With this model, I predicted robust VLF and T2-T5 motoneuron recruitment within the physiologic range of stimulation. Additionally, I designed two stimulation leads that maximize inspiratory neuron recruitment. The finalized leads were evaluated via in vivo experiments, which found excellent agreement with the model. This work builds our mechanistic understanding of this novel therapy, improves its implementation, and aids in future translational efforts towards human subjects.

Finally, I developed a computational model to evaluate closed-loop stimulation for chronic pain. This work characterized the neural origins of the evoked compound action potential (ECAP), the controlling biomarker of closed-loop stimulation. I modified my modeling methodology to predict ECAPs generated during low thoracic dorsal stimulation in humans, which matched with experimental measurements. This modeling work showed that ECAP properties depend on activation of a narrow range of neuron diameters and quantified how anatomical and stimulation factors (CSF thickness, stimulation configuration, lead position, pulse width) influence ECAP morphology, timing, and neural recruitment. These results improve our mechanistic understanding of closed-loop stimulation and may lead to expanded clinical utility as well as better validation of future SCS computational models.

Date: Friday, July 9, 2021

Time: 9:00 AM EDT

Zoom: https://umich.zoom.us/j/96847307388

Chair: Dr. Scott Lempka

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Lecture / Discussion Tue, 22 Jun 2021 16:45:26 -0400 2021-07-09T09:00:00-04:00 2021-07-09T10:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
BME Ph.D. Defense: Michael Bregenzer (July 21, 2021 9:00am) https://events.umich.edu/event/84438 84438-21623984@events.umich.edu Event Begins: Wednesday, July 21, 2021 9:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

High grade serous ovarian cancer (HGSOC) is the deadliest gynecological malignancy. Despite successful first line therapies, most patients relapse and develop more chemoresistant disease. This recurrence and development of chemoresistance is attributed to a rare population of tumor cells, termed cancer stem cells (CSCs), which are more chemoresistant, have the capacity to self-renew, and can repopulate the entire tumor. Research has shown that CSCs are maintained by the non-cancer cells in the tumor microenvironment (TME), such as mesenchymal stem cells (MSCs), endothelial cells (ECs), and immune cells. Furthermore, the role of non-cancer cells in clinical outcomes and chemoresistance has been highlighted by recent evidence showing that classification of HGSOC molecular subtypes, which have variable clinical prognoses, are influenced by the presence of non-cancer cells in the tumor. However, it is currently unclear exactly how CSCs and the nuanced cell composition of the TME work together to promote chemoresistance. Current models used to study these phenomena either suffer from a lack of cellular complexity in the case of many in vitro models or impractical experimental constraints such as long latency periods and poor control over cell composition in patient-derived xenografts. To better understand the role of CSCs and the TME cells in chemoresistance, practical in vitro model systems that more closely represent in vivo processes and microenvironments are needed. We hypothesize that the development of these in vitro model systems will contribute novel insights into TME-mediated CSC regulation and the development of chemoresistance in HGSOC.

In aim 1 we examined the emergence of chemoresistance in the context of CSCs by developing a 3D in vitro serial passaging model system that allows for long term culture of patient-derived tumor cells with periodic evaluation of stemness and chemoresistance. Using this model system, we demonstrated increased proliferation, expression of CSC markers, tumorigenicity, and chemoresistance over the course of long-term passaging, reflective of emerging chemoresistance in vivo. Furthermore, this system enabled us to define a malignant gene expression signature that is associated with chemoresistance, tumorigenicity, and stemness and to evaluate patient-specific chemoresistance development following treatment. Finally, we demonstrated the translational value of this model system by showing that Metformin treatment can hinder CSC driven development of chemoresistance in a phase II clinical trial.

In aim 2 we developed a heterogeneous tumoroid culture system that enabled culture of patient-derived tumor cells with controlled ratios of MSCs, ECs, and immune cells to study TME-mediated maintenance of CSCs and chemoresistance. Using this model, we found that changes in CD133+/-ALDH+/- CSC phenotypes in response to TME cells varied depending on the patient sample. We also observed increased tumorigenicity and chemoresistance in tumoroids compared to spheroids cultured with patient-derived tumor cells alone. Furthermore, we found evidence of epithelial-to-mesenchymal transition (EMT) in tumoroids accompanied by altered CSC phenotypes and a malignant matrisome signature. All of this together supports idea that the non-cancer cells in the TME contribute to the development of advanced, chemoresistant disease and implicates EMT, changes in CSC phenotypes, and matrix remodeling as the primary culprits.

Finally, in aim 3, we utilized this tumoroid system to generate tumoroids with 23 different cell compositions to evaluate the role of TME cell composition in response to therapy. Drug assays with novel and traditional chemotherapies revealed that tumoroids with different compositions respond differently to therapy and that the number of monocytes included in the culture was associated with the greatest resistance to therapy. Furthermore, our random forest models trained on the drug responses of each cell composition were able to predict drug response with moderate success. With these models we identified that nuanced differences in cell composition can influence drug response and that the strongest predictor of response to therapy was the total quantity of non-cancer cells. Overall, this model demonstrates the potential of using the TME composition to predict patient drug response and direct clinical management.

In these aims we demonstrate the clear utility of complex and realistic, yet practical in vitro model systems in the study of chemoresistance and CSC maintenance in ovarian cancer. Specifically, we identified the link between CSCs and the development of chemoresistance in long term 3D in vitro serial passage culture. Furthermore, we showed that the non-cancer cells in the TME can confer chemoresistance and promote EMT associated with altered CSC phenotypes and matrix remodeling. Lastly, we demonstrated the potential of TME composition in predicting drug response. Overall, the model systems presented in this study provide platforms that can be used to better understand the role of CSCs and the TME in chemoresistance and poor clinical outcomes. This could ultimately lead to the development of novel therapies, enhanced clinical management, and improved clinical outcomes.

Date: Wednesday, July 21, 2021
Time: 9:00 AM
Zoom: https://umich.zoom.us/j/96111622879
Password: 326862
Chair: Dr. Geeta Mehta

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Presentation Mon, 12 Jul 2021 12:13:44 -0400 2021-07-21T09:00:00-04:00 2021-07-21T10:00:00-04:00 Off Campus Location Biomedical Engineering Presentation BME Event
Precision Health Graduate Certificate Program (July 22, 2021 1:00pm) https://events.umich.edu/event/84318 84318-21623289@events.umich.edu Event Begins: Thursday, July 22, 2021 1:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

The new U-M Precision Health Graduate Certificate Program has arrived to educate current and future practitioners and researchers in this emerging field so they can become better equipped to customize patient care.

**Only 12 credits of graduate coursework required
**Great opportunity for graduate students to design their own plan
**Network with other precision health students and faculty at seminars and professional development workshops

**Mentoring with faculty

The certificate is open to all graduate students enrolled at U-M. Application deadline is August 1.

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Presentation Fri, 18 Jun 2021 14:24:55 -0400 2021-07-22T13:00:00-04:00 2021-07-22T13:30:00-04:00 Off Campus Location Department of Learning Health Sciences Presentation researchers, learners and health professional in lab, classroom and clinic setting
Precision Health Graduate Certificate Program - Information Session (July 22, 2021 1:00pm) https://events.umich.edu/event/84201 84201-21620757@events.umich.edu Event Begins: Thursday, July 22, 2021 1:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Plan to attend this information session to learn more about the growing field of precision health which seeks to tailor health care for individuals via a multidisciplinary, data-driven approach.

The new U-M Precision Health Graduate Certificate Program has arrived to educate current and future practitioners and researchers in this emerging field so they can become better equipped to customize patient care.

**Only 12 credits of graduate coursework required
**Great opportunity for graduate students to design their own plan
**Network with other precision health students and faculty at seminars and professional development workshops
**Mentoring with faculty

The certificate is open to all graduate students enrolled at U-M. Application deadline is August 1.

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Other Thu, 03 Jun 2021 11:00:29 -0400 2021-07-22T13:00:00-04:00 2021-07-22T13:30:00-04:00 Off Campus Location Department of Learning Health Sciences Other learners and researchers in lab, classroom and research settings
BME Ph.D. Defense: Yuan Li (July 22, 2021 2:00pm) https://events.umich.edu/event/84452 84452-21624017@events.umich.edu Event Begins: Thursday, July 22, 2021 2:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults and has a poor prognosis with a median survival of approximately 14 months. Clinical standard assessment of therapy response and tumor progression is based upon post-contrast T1-weighted (T1W) and fluid-attenuated inversion recovery (FLAIR) T2-weighted (T2W) magnetic resonance images (MRI).  However, contrast enhancement observed on the post-contrast T1W MRI is affected not only by tumor growth but also effects of radiation, anti-angiogenesis drugs and chemotherapy, due to the fact that it represents blood-brain barrier disruption. Another problem is that abnormality on T2W FLAIR images is influenced by T2 changes of tumor cells as well as edema and necrosis that always co-exist within GBM. Diffusion weighted (DW) imaging has been proposed to overcome these limitations. Conventional DW images quantify apparent diffusion coefficient (ADC) with b-values between 0 and 1000 s/mm2 using a mono-exponential decay. One limitation is that co-existence of edema in clinical GBM elevates ADC.
 
In diffusion MRI, there are three dimensions of parameter spaces that we could explore in research —b value, diffusion time (t) and echo time (TE). Hence, we investigated and developed high order diffusion models in these three spaces and evaluated whether they could reveal more features of GBM.
 
In the b-value space, we investigated a microstructure model (MSM), in which modulation of diffusion gradient with cell size is considered, with high b-value diffusion images in the patients with GBM pre-radiation therapy (RT). We found apparent cell size (ARS), extracellular diffusion coefficient (Dex) and intracellular fractional volume (Vin) in tumor were significantly greater than ones in normal tissue and edema. In addition, we investigated diffusion kurtosis imaging (DKI) in GBM pre-RT and mid-RT, and found pre-RT mean kurtosis of the tumor could provide a predictive value of overall survival (OS) additional to clinical prognostic factors.
 
In the TE space, T2-Relaxation-Diffusion correlation experiments can be powerful in resolving water compartments with respect to their size and chemical composition, but the problem is ill-posed. We simplified the T2-Relaxation-Diffusion correlation to consider the T2 values and diffusion coefficients in a 2x2 fashion. We found that there were significant differences between fast and slow diffusion coefficients and between associated T2 values in tumor, cortex, deep GM, and edema. Multivariate Cox model showed the fractional volume of slow component (Vs) mid-RT may add a predictive value to clinical factors.
 
In diffusion time space, we applied three different diffusion times using pulsed diffusion gradients (PG) and oscillating gradients at frequencies of 30 Hz (OS30) and 50 Hz (OS50) using a prototype sequence. Using a random walk with barriers model, we estimated cell diameter, unrestricted diffusion coefficient (D0) at a short time limit, bulk diffusion coefficient (Dinf) at a long time limit, cell membrane permeability and effective restriction in the contrast-enhanced tumor. Those parameters provide microstructural information in the GBM and need to be further investigated and validated with pathology.
 
Previous studies have mainly investigated high order diffusion models in prostate cancer and xenograft tumor models, and only a few studies investigated GBM. The current knowledge about the relationship between model parameters and physiological/pathological features in GBM are still limited. Our research in GBM could lead to better imaging means for GBM diagnosis, tumor target definition for radiation therapy, and therapy response assessment.
 
Date: Thursday, July 22, 2021
Time: 2:00 PM
Zoom: https://umich.zoom.us/j/96213084276

Chair: Dr. Yue Cao

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Presentation Tue, 13 Jul 2021 13:47:02 -0400 2021-07-22T14:00:00-04:00 2021-07-22T15:00:00-04:00 Off Campus Location Biomedical Engineering Presentation BME Event
BME PhD Defense: Emine Sumeyra Turali-Emre (August 2, 2021 1:00pm) https://events.umich.edu/event/84794 84794-21624994@events.umich.edu Event Begins: Monday, August 2, 2021 1:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Biomimetic nanoparticles (NPs) are bio-inspired inorganic nanoscale materials that replicate some biological nanostructures functionalities including self-assembly, catalysis, and enzyme inhibition. These functionalities are being investigated for and, in some cases, are being utilized in optics and electronics such as chemical sensors, superhydrophobic coatings, and antireflective surfaces. This thesis examines the utilization of biomimetic inorganic NPs for various problems in biomedical engineering.

Specifically, in the first part of this thesis, I address the problem on controversial explanations of the antibacterial and other biological activity of zinc oxide NPs that are frequently utilized in cosmetics, textiles, and biomedical fields. In the second part of the thesis, I explore the self-organization of NPs into biomimetic supraparticles (SPs) for nucleic acid delivery that can be exploited as drug delivery agents.

NPs have been used in the antimicrobial field for a long time; however, their antibacterial mechanism of action against different types of bacteria remains unclear and, in many cases, misinterpreted. Most of the studies on antimicrobial NPs suggest reactive oxygen species (ROS) formation, ion release, and membrane damage as the primary source of antibacterial activity. In Chapter 2, we show that the mechanism of antibacterial activity for Staphylococcus aureus is remarkably more complex than generating ROS or the release of Zn2+ ions and is based on formation of biomimetic complexes of NPs with proteins. Gene expression analysis demonstrated that ZnO-NPs significantly affect carbohydrate metabolism and cell energetics, where the uridine monophosphate (UMP) biosynthesis pathway is highly upregulated. In Chapter 3, we explore the ZnO-NP mode of entry into S. aureus and the cell metabolism. Here, we showed that NPs enter the cells within 5 minutes of exposure and induce minimal membrane damage. We note that cells do not depolarize until 60 min post-NPs exposure. Thereby, we highlight that membrane damage is not the primary mechanism of action but rather a downstream effect of ZnO-NPs exposure to bacterial cells. Taken together, causing minimal ROS production and significant changes in carbohydrate metabolism and bioenergetics along with cell entry without immediate membrane damage imply the biomimetic function of these NPs. Further investigation into the antimicrobial mechanisms of biomimetic NPs is essential for future clinical translation.

Over the past few decades, there has been considerable interest in developing nanoscale constructs as effective delivery tools for high molecular weight drugs. In chapter 4, I explore the self-assembly of NPs into compartmentalized SPs, which mimics the structure of a virus to deliver nucleic acid into cells. The time-dependent self-assembly mechanism reveals that these SPs are formed from nanocup intermediates. We found that this intermediate stage is essential for the utilization of SP compartments. Nucleic acid is added to the system at this stage before SP formation, and high encapsulation is achieved. Similar to virus infections, once cells uptake the SP, SP disassociates in endosomes and releases the cargo.

Overall, the work presented in this thesis investigates and highlights the strong potential of biomimetic inorganic NPs use in next-generation biomedical applications.

Date: Monday, August 2, 2021
TIme: 1:00PM
Zoom: https://umich.zoom.us/j/95043183845
Chair: Prof. Nicholas Kotov

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Presentation Wed, 28 Jul 2021 12:34:40 -0400 2021-08-02T13:00:00-04:00 2021-08-02T14:00:00-04:00 Off Campus Location Biomedical Engineering Presentation BME Event
BME PhD Defense: Daniel Clough (August 4, 2021 10:00am) https://events.umich.edu/event/84844 84844-21625176@events.umich.edu Event Begins: Wednesday, August 4, 2021 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

Type 1 diabetes is caused by the autoimmune destruction of insulin-producing β-cells, resulting in a chronic metabolic disorder typically treated with exogenous insulin. Even with the aid of advanced insulin pumps and real time feedback systems, blood glucose levels still deviate outside of the range maintained by native islets, which places the individual at risk for vascular complications and life-threatening hypoglycemic events. Cell replacement therapies have demonstrated the capacity to tightly control blood glucose levels. The wide adoption of cell replacement therapy is hindered by limited availability of donor islets, and the lack of effective methods to support the long-term function of these cells within a clinically accessible site. The results presented in this thesis address these limitations: through studying maturation of human pluripotent progenitor cell (hPPC) derived β cells within a transplantable biomaterial platform, and evaluating novel approaches to the implantation and support of these cells during their continued maturation in vivo.

First, I present a study that examined delivery of hPPC-derived pancreatic progenitors within microporous PLG scaffolds into the epididymal fat pad, the murine surrogate for the clinically relevant omental pouch. Kidney capsule injection, the site most commonly utilized to test stem cell-derived β cell function in murine models, was the comparison condition. We observed that the microporous scaffolds supported cell engraftment, however the levels of circulating C-peptide were lower when compared to the kidney capsule condition. The scaffolds were subsequently modified to provide sustained release of exendin-4, which led to significantly increased C-peptide production. Image analysis revealed that exendin-4 releasing scaffolds enhanced the proportion of pancreatic progenitors that matured to monohormonal insulin producing cells.

Next I present my findings from studying how hPPC-derived β cells mature and function within three transplantation sites: the i) scaffold delivery into the epididymal fat pad, ii) scaffold delivery into the subcutaneous space, and iii) the kidney capsule injection (control). Additionally, we investigated the impact of blood glucose levels on maturation of the hPPC-derived β cells by transplanting mice with pre- or post-engraftment diabetes induction. Hyperglycemia was ameliorated in the cohorts of mice that received scaffolds into the epididymal fat pad, following a period of in vivo maturation. The function of these cells was demonstrated by the reduction in blood glucose levels, healthy increase in weight, therapeutic levels of circulating human insulin, and healthy responses to glucose challenge tests. The function from the epididymal fat pad was superior to the subcutaneous space and was observed to be comparable to the kidney capsule. No differences were observed in graft function between the cohorts whose grafts matured in a diabetic or non-diabetic environment, yet several differences in gene expression were observed.

Many of the current differentiation protocols culture the cells above a feeder layer in monolayer, or in suspension within a bioreactor. Typically, these protocols require the disruption of the cell niche during key differentiation stages or pre-transplantation handling. Biomaterial scaffolds maintain the integrity of cell-to-cell and cell-to-matrix connections by providing both a space for cell niche development as well as a vehicle for transplantation into the body. Herein, I present results from testing the developmental stage in which progenitors are seeded into the 3D niche, and two differentiation strategies prior to seeding: monolayer and suspension culture. Maturation was characterized via gene expression analysis, glucose stimulated insulin secretion assay, and nondestructive microscopy utilizing a sfGFP-C-peptide cell line that reports C-peptide production and secretion. We observed that seeding clusters during the key transition phase from pancreatic progenitor to pancreatic endocrine enhanced commitment to the final beta cell fate.

This work enhances our understanding of hPPC-derived beta cell manufacturing within scaffolds, and delivery to an extrahepatic site to achieve normoglycemic blood glucose levels.

Date: Wednesday, August 4, 2021
Time: 10:00 AM
Zoom: https://umich.zoom.us/j/98009467275
Password: betacell
Chair: Dr. Lonnie Shea

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Presentation Mon, 02 Aug 2021 10:58:53 -0400 2021-08-04T10:00:00-04:00 2021-08-04T11:00:00-04:00 Off Campus Location Biomedical Engineering Presentation BME Event
BME PhD Defense: Dorsa Haji Ghaffari (August 5, 2021 11:00am) https://events.umich.edu/event/84795 84795-21624995@events.umich.edu Event Begins: Thursday, August 5, 2021 11:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

Retinal prostheses have restored a sense of vision in patients blinded by photoreceptor degeneration. These electronic implants operate by electrically stimulating the remaining retinal cells. While retinal prosthesis users report improvements in light perception and performing basic visual tasks, their ability to perceive shapes and letters remains limited. Investigating stimulation strategies to reduce perceptual thresholds and create focal, non-overlapping phosphenes will increase the resolution of retinal prostheses and improve the overall patient outcomes. In this thesis I explore two main strategies for electrode-specific optimization of stimulation parameters: 1) a novel pulse paradigm for threshold reduction, and 2) an automated closed-loop method for adjusting stimulation parameters to create a focal retinal activation area.

I combined human subject testing and computational modeling to investigate the effect of waveform asymmetry on perception shapes and thresholds with epiretinal stimulation. Threshold measurement and phosphene shape analysis was performed on four Argus II users. A computational model of a retinal ganglion cell (RGC) was created in the NEURON simulation environment to allow for a more thorough parameter testing and to gain insight into the biophysical mechanisms. Our human subject results suggest that asymmetric waveforms could increase perception probabilities compared to a standard symmetric pulse, and this effect can be intensified by addition of an interphase gap (IPG). Our in silico model predicts that the most effective pulse for threshold reduction is asymmetric anodic-first stimulation with small duration ratios (≤ 5) and long IPGs (≥ 2 ms). Phosphene shape analysis revealed no significant difference in percept elongation with different pulse types. Average phosphene area was larger with asymmetric anodic-first stimulation compared to other pulse types.

Prosthetic vision quality is highly dependent on the capability to precisely activate target neurons and avoid off-target activation. However, studies show elongated and inconsistent responses to single electrode stimulation, indicating unintended stimulation of off-target neurons and electrode-specific activation patterns. While tuning stimulation parameters can transform the spatial RGC activity, a manual search for optimal parameters can be time consuming and tiring for patients. I developed a process for automatic optimization of stimulation parameters in silico, which involved training neural networks for quantifying the relationship between pulse parameters and spatial response descriptors, and a closed-loop algorithm to search for optimal parameters. Using this process, I was able to guide the parameter search effectively and converge to an optimal response within a few iterations.

Finally, I presented a process for automatic optimization of stimulation parameters in vitro using calcium imaging in mouse retina. This process involved training neural networks at each iteration based on a few images, using an interior point algorithm to find the optimal parameters, and classifying the resulting calcium images with a CNN trained on previous data. Our results indicate that we can converge to optimal stimulation parameters that create focal RGC activity by sampling less than 1/3 of the parameter space. This approach can shorten the exploration time significantly compared to a manual search, especially when the parameter space is large. Findings of this project could lead to the development of a clinically applicable system for electrode-specific optimization of stimulation protocol, improving the overall outcome of artificial vision.

Date: Thursday, August 5, 2021
Time: 11:00 AM
Zoom: https://umich.zoom.us/j/93552322970
Chair: Dr. James Weiland

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Presentation Wed, 28 Jul 2021 12:42:01 -0400 2021-08-05T11:00:00-04:00 2021-08-05T12:00:00-04:00 Off Campus Location Biomedical Engineering Presentation BME Event
BME PhD Defense: Ahmet Emre (August 9, 2021 2:00pm) https://events.umich.edu/event/84859 84859-21625204@events.umich.edu Event Begins: Monday, August 9, 2021 2:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Energy storage is an integral part of life. Living creatures have developed a distributed and structural energy storage system to survive under various and sometimes extreme conditions. Similarly, energy storage is critical for modern life to power from small biomedical instruments to large aircraft. There are still several challenges against efficient and safe energy storage utilization due to the mechanical, chemical, and physical limitations of existing materials. Inspired by biological structures, we present multifunctional nanocomposites from aramid nanofibers (ANF), a nanoscale version of Kevlar, to address the safety and efficiency of various battery chemistries and enable structural energy storage to increase energy density. High mechanical properties of ANF suppress dendrite formation, and tunability with different copolymers and fabrication methods allow ANF-based nanocomposites to meet specific needs of different battery chemistries.

In the first part of this thesis, we engineered biomimetic solid electrolyte from ANF and polyethylene oxide for zinc batteries inspired by the cartilage structure. These strong nanocomposites can block stiff zinc dendrite and prevent short circuits over cycles. Resilience to plastic deformation and damage while having no leaking fluids or cracks is essential for the safety of, for instance, electrical vehicles employing such batteries. These load-bearing batteries can be used as a structural component and increase energy density by simply avoiding inactive parts. As a proof of concept, we utilized this battery on a commercial drone as an auxiliary energy storage unit to extend flight endurance by about 20%.

The second part of the thesis addresses a specific polysulfide shuttle problem in lithium-sulfur batteries utilizing bioinspired ANF nanocomposites. Mimicking ion channels on the cell membrane, we engineered biomimetic nanochannels (1nm diameter) for selectively allowing lithium-ion passage while physically blocking lithium polysulfide species (>2nm) on the cathode side. Selective ion transport through nanochannels is also modeled by finite element analysis, COMSOL. These ion channels allow us to reach >3500 cycles.

In addition to previous solid and liquid electrolyte systems, here in the last part of the thesis, we present a tunable quasi-solid polymer electrolyte to take advantage of both electrolyte features while minimizing their individual risks and drawbacks. Similar to the kidney filtration system, specifically the glomerular basement membrane, this gel electrolyte filters ions depending on their size and charge. Selective permeability and regulated ion transport provide safe and stable charge/discharge cycles. High mechanical properties keep functionality under extreme conditions, including high temperature and nail penetration. We integrated pouch cells in various prototypes to show practical utilization of our structural batteries, including health monitoring devices, robotic prosthetics, and electric vehicles.

Taken together, mimicking structural and functional properties of multifunctional biological materials, i.e., cartilage, we present a novel multifunctional nanocomposite system that can be tailored to the specific needs of numerous structural energy storage applications.

Date: Monday, August 9, 2021
Time: 2:00 PM
Zoom: https://umich.zoom.us/j/92570283886
Chair: Prof. Nicholas Kotov

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Presentation Mon, 02 Aug 2021 12:53:44 -0400 2021-08-09T14:00:00-04:00 2021-08-09T15:00:00-04:00 Off Campus Location Biomedical Engineering Presentation BME Event
BME Master's Defense: Hind AlYahya (August 10, 2021 1:00pm) https://events.umich.edu/event/84890 84890-21625248@events.umich.edu Event Begins: Tuesday, August 10, 2021 1:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Peripheral arterial disease (PAD) is a disorder that restricts the blood flow in arteries that carry blood to the limbs; it frequently affects the legs. This restriction occurs due to severe atherosclerosis (stenosis), an accumulation of fatty materials in the vessel lumen. Stents are used to manage this disease. However, in-stent restenosis can occur at an unpredictable time, leading to emergency hospitalization or death.

The wireless magnetoelastic monitoring system showed its potential to detect restenosis. The main components of this system are a miniaturized wireless sensor integrated into the stent and a bias magnet. The purpose of using a magnet is to provide a uniform magnetic field for the sensor to operate. This work aims to improve the design of the system components to be compatible with the commercial self-expanding vascular stents. The magnetoelastic sensor was designed to fit with a conventional self-expanding stent (e.g., Innova™ from Boston Scientific Corp.) used to treat superficial femoral artery lesions. It is designed to be a single layer of MetglasTM 2826MB (12 mm x 0.85 mm x 29 um). However, the sensor could be damaged during the stent deployment. As a result, it is necessary to encapsulate the sensor. A polymeric package was designed to house the sensor and the biasing magnet. The package is attached to the stent structure by two helical wires made of nitinol material. The biasing magnet is a strip of ArnokromeTM 5 (13.2 mm x 0.85 mm x 50 um). FEA tool was used to evaluate the performance of the sensor and the magnetic strip. The results showed that the sensor vibrates at 149 kHz. The magnetic field distribution confirmed that the ArnokromeTM 5 generates a sufficient magnetic field strength for the sensor to operate. This work also covers an analytical analysis of using electromagnetic coils to provide DC bias for the system. However, the results showed that the heat dissipated from the coils could be hard to manage.

If implanting this package is successful *in vivo* experiments, the detection of restenosis will be achieved in an earlier stage, saving the patient from undergoing another surgery. Therefore, the wireless monitoring system can reduce emergency surgeries and mortality that results from PAD, leading to healthier patients and a lower burden on hospital resources.

Date: Tuesday, August 10, 2021
Time: 1:00 PM
Zoom: https://umich.zoom.us/j/99281419966
Chair: Prof. Yogesh B. Gianchandani

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Presentation Tue, 03 Aug 2021 10:09:05 -0400 2021-08-10T13:00:00-04:00 2021-08-10T14:00:00-04:00 Off Campus Location Biomedical Engineering Presentation BME Event
Medical Illustration: Finding my niche in science with Dr. Jeff Day (August 20, 2021 11:00am) https://events.umich.edu/event/84938 84938-21625387@events.umich.edu Event Begins: Friday, August 20, 2021 11:00am
Location: Off Campus Location
Organized By: American Chemical Society Polymer Division – Student Chapter (ACS POLY/PMSE)

What is medical illustration and what does it have to do with you? Come learn about this tiny specialty that employs only a couple thousand people across our entire continent with Johns Hopkins medical illustrator Jeff Day. He will overview the field, share his personal career path, his professional interests and what he is looking to explore next. Along the way, Jeff will sprinkle his thoughts on searching for and finding his niche in science, and share communication lessons from medical illustration that can help with any field.

Please RSVP here: https://forms.gle/bSTCEADEv2LuvxYB6

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Workshop / Seminar Thu, 05 Aug 2021 09:26:28 -0400 2021-08-20T11:00:00-04:00 2021-08-20T12:00:00-04:00 Off Campus Location American Chemical Society Polymer Division – Student Chapter (ACS POLY/PMSE) Workshop / Seminar Poster
Artscapade! (August 28, 2021 6:00pm) https://events.umich.edu/event/84810 84810-21625050@events.umich.edu Event Begins: Saturday, August 28, 2021 6:00pm
Location: Museum of Art
Organized By: University of Michigan Museum of Art (UMMA)

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UMMA and Arts at Michigan celebrate Welcome Week by introducing new University of Michigan students to the Museum of Art for an evening of  live music, performances, dance, poetry, film, games, prize raffle, and a variety of art-making activities.  During the event, students will  have the opportunity to become familiar with the Museum and everything it has to offer, as well as experience the wide array of possibilities for arts participation across campus. 

All students, faculty and staff on the Ann Arbor (including Michigan Medicine), Dearborn and Flint campuses are required to be vaccinated against COVID-19 and submit their vaccination information by August 30. In addition, masks will be required in all indoor spaces and social distancing guidelines will be in place.

Student programming at UMMA is generously supported by the University of Michigan Credit Union Arts Adventures Program, UMMA's Lead Sponsor for Student and Family Engagement.

 

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Presentation Sun, 29 Aug 2021 00:15:49 -0400 2021-08-28T18:00:00-04:00 2021-08-28T21:00:00-04:00 Museum of Art University of Michigan Museum of Art (UMMA) Presentation Museum of Art
U-M Food Drive for Food Gatherers (September 1, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631588@events.umich.edu Event Begins: Wednesday, September 1, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-01T08:00:00-04:00 2021-09-01T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
U-M Food Drive for Food Gatherers (September 2, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631589@events.umich.edu Event Begins: Thursday, September 2, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-02T08:00:00-04:00 2021-09-02T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
U-M Food Drive for Food Gatherers (September 3, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631590@events.umich.edu Event Begins: Friday, September 3, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-03T08:00:00-04:00 2021-09-03T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
U-M Food Drive for Food Gatherers (September 4, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631591@events.umich.edu Event Begins: Saturday, September 4, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-04T08:00:00-04:00 2021-09-04T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
U-M Food Drive for Food Gatherers (September 5, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631592@events.umich.edu Event Begins: Sunday, September 5, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-05T08:00:00-04:00 2021-09-05T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
U-M Food Drive for Food Gatherers (September 6, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631593@events.umich.edu Event Begins: Monday, September 6, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-06T08:00:00-04:00 2021-09-06T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
U-M Food Drive for Food Gatherers (September 7, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631594@events.umich.edu Event Begins: Tuesday, September 7, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-07T08:00:00-04:00 2021-09-07T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
Building Connections & Meaningful Relationships (September 7, 2021 1:00pm) https://events.umich.edu/event/86290 86290-21634311@events.umich.edu Event Begins: Tuesday, September 7, 2021 1:00pm
Location:
Organized By: Michigan Medicine Wellness Office

Starting a new school year can be tough, and one of the most important pieces of well-being and academic success require meaningful relationships.

Please register to attend! https://sessions.studentlife.umich.edu/track/event/session/45582

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Well-being Tue, 07 Sep 2021 13:53:29 -0400 2021-09-07T13:00:00-04:00 2021-09-07T14:00:00-04:00 Michigan Medicine Wellness Office Well-being Wellness Office Logo
U-M Food Drive for Food Gatherers (September 8, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631595@events.umich.edu Event Begins: Wednesday, September 8, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-08T08:00:00-04:00 2021-09-08T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
Department of Computational Medicine & Bioinformatics || Weekly Seminar Series (September 8, 2021 4:00pm) https://events.umich.edu/event/86237 86237-21632210@events.umich.edu Event Begins: Wednesday, September 8, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

Structural variants (SVs) are a source of pathogenic variants in a clinical referral population, however, they are often under-reported due to technical limitations of detection and difficulty with clinical interpretation. For example, mobile element insertions (MEIs) are estimated to lead to a positive finding in 1 out of 1000 rare genetic disease cases, yet the numbers are far lower in clinical diagnostic laboratories. Targeted NGS with short insert size libraries, unlike genome sequencing, will have very few discordant read pairs to indicate the presence of an SV. We, therefore, developed an SV detection tool called SCRAMble (Soft Clipped Read Alignment Mapper) to identify SV breakpoints in targeted NGS.

We applied SCRAMble to a prospective clinical referral cohort for exome sequencing to identify deletions and MEIs. We also applied SCRAMble to a hereditary cancer panel assay for the identification of a large inversion involving the MSH2 gene that causes Lynch syndrome. Adding breakpoint detection to clinical targeted sequencing identifies positive findings which were missed by prior testing and by other variant callers. Detecting breakpoints allows for more precise interpretation and for more targeted confirmation assays. By applying SV breakpoint detection, we are able to diagnose ~0.3% more cases. While this is a modest gain in diagnostic yield, for the patients and families involved, a positive diagnosis, even after prior testing, can have a meaningful impact on their lives.

Zoom link: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Thu, 02 Sep 2021 14:28:18 -0400 2021-09-08T16:00:00-04:00 2021-09-08T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual Rebecca Torene, Associate Director of Genomics Research | Data Science at GeneDx
Building Connections & Meaningful Relationships (September 8, 2021 6:00pm) https://events.umich.edu/event/86290 86290-21632591@events.umich.edu Event Begins: Wednesday, September 8, 2021 6:00pm
Location: Off Campus Location
Organized By: Michigan Medicine Wellness Office

Starting a new school year can be tough, and one of the most important pieces of well-being and academic success require meaningful relationships.

Please register to attend! https://sessions.studentlife.umich.edu/track/event/session/45582

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Well-being Tue, 07 Sep 2021 13:53:29 -0400 2021-09-08T18:00:00-04:00 2021-09-08T19:00:00-04:00 Off Campus Location Michigan Medicine Wellness Office Well-being Wellness Office Logo
U-M Food Drive for Food Gatherers (September 9, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631596@events.umich.edu Event Begins: Thursday, September 9, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-09T08:00:00-04:00 2021-09-09T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
U-M Food Drive for Food Gatherers (September 10, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631597@events.umich.edu Event Begins: Friday, September 10, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-10T08:00:00-04:00 2021-09-10T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
Lecture: Bon Ku, Thomas Jefferson University Health Design Lab (September 10, 2021 12:00pm) https://events.umich.edu/event/85866 85866-21629404@events.umich.edu Event Begins: Friday, September 10, 2021 12:00pm
Location:
Organized By: A. Alfred Taubman College of Architecture + Urban Planning

Bon Ku is the Director of the Health Design Lab at Thomas Jefferson University where he created the first design thinking program at a medical school. He is the Marta and Robert Adelson Professor of Medicine and Design, the Associate Dean for Health & Design and a practicing emergency physician. His work toward redesigning healthcare has been featured in The New York Times, CNBC, Architectural Digest and Fast Company. Dr. Ku has spoken at conferences, academic medical centers and universities around the world: SXSW, TEDx, Yale School of Management, American Institute of Architects and Singapore Design Week. Dr. Ku is the host of the Design Lab Podcast, co-wrote the book, Health Design Thinking, with Ellen Lupton and was a regular panelist on the primetime medical TV show Chasing the Cure with Ann Curry.

This event will be held in-person at the Art & Architecture Building (2000 Bonisteel Blvd., Ann Arbor, MI), room 1360, and will also be live-streamed. Please register for the event to attend or to receive the link for the virtual streaming: https://umich.formstack.com/forms/bon_ku

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Lecture / Discussion Wed, 01 Sep 2021 09:59:47 -0400 2021-09-10T12:00:00-04:00 2021-09-10T13:00:00-04:00 A. Alfred Taubman College of Architecture + Urban Planning Lecture / Discussion Health Design Diagram
Human Genetics Annual Retreat - Keynote Seminar (September 10, 2021 2:00pm) https://events.umich.edu/event/86250 86250-21632243@events.umich.edu Event Begins: Friday, September 10, 2021 2:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Department of Human Genetics

FRIDAY, SEPTEMBER 10
2:00 PM – 3:00 PM EST
BSRB KAHN AUDITORIUM
109 ZINA PITCHER PL, ANN ARBOR

HOSTED BY:
Jacob Mueller, Ph.D.
Associate Professor of Human Genetics
Associate Professor of Obstetrics and Gynecology
Associate Professor of Urology
University of Michigan

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Lecture / Discussion Thu, 02 Sep 2021 16:36:15 -0400 2021-09-10T14:00:00-04:00 2021-09-10T15:00:00-04:00 Taubman Biomedical Science Research Building Department of Human Genetics Lecture / Discussion DHG RETREAT 2021_Keynote Speaker Flyer
U-M Food Drive for Food Gatherers (September 11, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631598@events.umich.edu Event Begins: Saturday, September 11, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-11T08:00:00-04:00 2021-09-11T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
U-M Food Drive for Food Gatherers (September 12, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631599@events.umich.edu Event Begins: Sunday, September 12, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-12T08:00:00-04:00 2021-09-12T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
U-M Food Drive for Food Gatherers (September 13, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631600@events.umich.edu Event Begins: Monday, September 13, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-13T08:00:00-04:00 2021-09-13T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
How Safe Is Safe Enough: Analyzing Hazards and Risks in the Real World to Inform Decision Making (September 13, 2021 4:30pm) https://events.umich.edu/event/86451 86451-21634340@events.umich.edu Event Begins: Monday, September 13, 2021 4:30pm
Location: Industrial and Operations Engineering Building
Organized By: Center for Healthcare Engineering & Patient Safety (CHEPS)

No endeavor/decision is without risk. Despite the best of intentions decisions that lead to undesired outcomes (financial, human, political, reputation), many times catastrophic, occur during the operation of complex systems. Unfortunately (tragically), it is also common that the parties that made these decisions or were impacted by these undesired outcomes viewed them as unexpected when they occurred. Even worse, because the outcomes were unexpected there was generally little or no preparation for their occurrence further magnifying the extent and the impact to the individuals, organizations, and society as a whole. Since no system can be reasonably expected to perform flawlessly and with perfection all of the time, the hazards that can cause undesired outcomes should be proactively identified and their associated risks should be either mitigated or the residual risk after mitigation should be accepted by those entities responsible for the system in question. Unfortunately, history shows us that this is often not the case and arises from myriad reasons. Engineering risk analysis provides a systematic, holistic approach for addressing risks associated with complex technical systems. The irony is that few engineers are ever introduced to or learn how to apply this knowledge in their professional activities. A discussion of approaches, including real world examples, to proactively identify hazards, their associated risks, and potential mitigation approaches that can mitigate the likelihood that an unacceptable outcome will occur.

Dr. James P. Bagian is a co-founder and the Executive Director of the Center for Risk Analysis Informed Decision Engineering (RAIDE) and is a Professor in the Departments of Industrial and Operations Engineering, Aerospace Engineering, and the Department of Anesthesiology at the University of Michigan. He has extensive experience in the fields of human factors, aviation, patient and transportation safety, and risk assessment and management. Dr. Bagian was also the founding Director of the Center for Healthcare Engineering and Patient Safety at the University of Michigan. Previously he served as the first and founding director of the Department of Veterans Affairs National (VA) Center for Patient Safety and was the VA’s first Chief Patient Safety Officer where he developed numerous systems and risk based tools and programs that have been adopted nationally and internationally. A NASA astronaut, he is a veteran of two Space Shuttle missions and has also served as the Chief Flight Surgeon and Medical Consultant for the Space Shuttle Columbia Accident Investigation Board as well as being an investigator for the Space Shuttle Challenger mishap investigation. He was elected to two terms as the Chair of the Joint Commission’s Patient Safety Advisory Group and was a member of NASA’s Aerospace Safety Advisory Panel from 2006-2018. Bagian holds a B.S. degree in mechanical engineering from Drexel University and a doctorate in medicine from Thomas Jefferson University. He is a Fellow of the Aerospace Medical Association and is an elected member of the National Academy of Engineering and the National Academy of Medicine.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach. For the Zoom link and password and to be added to the weekly e-mail for the series, please RSVP. For additional questions, contact CHEPSseminar@umich.edu. Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Tue, 07 Sep 2021 16:17:10 -0400 2021-09-13T16:30:00-04:00 2021-09-13T17:30:00-04:00 Industrial and Operations Engineering Building Center for Healthcare Engineering & Patient Safety (CHEPS) Lecture / Discussion James P. Bagian, MD, PE
Please join us for an evening conversation between Emma Green and Charlie Camosy on Dr. Camosy's new book Losing Our Dignity: How Secularized Medicine is Undermining Fundamental Human Equality. (September 13, 2021 7:00pm) https://events.umich.edu/event/84807 84807-21625037@events.umich.edu Event Begins: Monday, September 13, 2021 7:00pm
Location: Off Campus Location
Organized By: The University of Michigan Medical School Program on Health, Spirituality and Religion

Emma Green - Staff Writer at The Atlantic

AND

Charles Camosy, PhD
Associate Professor of Theology, Fordham University

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Workshop / Seminar Thu, 29 Jul 2021 10:28:46 -0400 2021-09-13T19:00:00-04:00 2021-09-13T20:00:00-04:00 Off Campus Location The University of Michigan Medical School Program on Health, Spirituality and Religion Workshop / Seminar
U-M Food Drive for Food Gatherers (September 14, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631601@events.umich.edu Event Begins: Tuesday, September 14, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-14T08:00:00-04:00 2021-09-14T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
U-M Food Drive for Food Gatherers (September 15, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631602@events.umich.edu Event Begins: Wednesday, September 15, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-15T08:00:00-04:00 2021-09-15T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
Department of Computational Medicine & Bioinformatics Weekly Seminar Series (September 15, 2021 4:00pm) https://events.umich.edu/event/86598 86598-21635116@events.umich.edu Event Begins: Wednesday, September 15, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

Chromosomal instability (CIN) results in the accumulation of large-scale losses, gains, and rearrangements of DNA. The broad genomic complexity caused by CIN is a hallmark of cancer, however, there is no systematic framework to measure different types of CIN and their impact on clinical phenotypes. Here, we evaluate the extent, diversity and origin of chromosomal instability across 7,880 tumors representing 33 cancer types from the TCGA collection. We present a compendium of 17 copy number signatures characterizing specific types of CIN, with putative aetiologies supported by multiple independent data sources. The signatures predict drug response and identify new drug targets. Our framework refines the understanding of impaired homologous recombination, one of the most therapeutically targetable types of CIN. Our results illuminate a fundamental structure underlying genomic complexity and provide a resource to guide future CIN
research in human cancers.

Bio:

Florian Markowetz is a Senior Group Leader at the Cancer Research UK Cambridge Institute. He is a Royal Society Wolfson Research Merit Award holder and received a CRUK Future Leader in Cancer Research prize. He holds degrees in Mathematics (Dipl. math.) and Philosophy (M.A.) from the University of Heidelberg and a Dr. rer. nat. (PhD equivalent) in Computational Biology from Free University Berlin, for which he was awarded an Otto-Hahn Medal by the Max Planck Society. His group at the CRUK Cambridge Institute combines computational work on cancer evolution and image analysis of the tumor tissue with experimental work on understanding key cancer mechanisms like the estrogen receptor.

Zoom link: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Thu, 09 Sep 2021 11:24:05 -0400 2021-09-15T16:00:00-04:00 2021-09-15T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual Florian Markowetz (Senior Group Leader at the Cancer Research UK Cambridge Institute)
"The History of Anatomy - From Alcmaeon to Skandalakis" (HYBRID EVENT) (September 15, 2021 6:30pm) https://events.umich.edu/event/86488 86488-21634731@events.umich.edu Event Begins: Wednesday, September 15, 2021 6:30pm
Location: Off Campus Location
Organized By: The Society for the History and Philosophy of Medicine

**HYBRID EVENT** View details below with RSVP required at event in person.

Title: The History of Anatomy - From Alcmaeon to Skandalakis
by Dr. Christian Vercler

The Plastic Surgery Student Interest Group (PSIG) and the Society for the History and Philosophy of Medicine, are joining together to host an in person and virtual hybrid event titled "The History of Anatomy - From Alcmaeon to Skandalakis" on Wednesday September 15th, 2021 from 6:30-7:30 pm, which will be facilitated by Dr. Christian Vercler. Snacks will be provided for those joining us in person. Please RSVP using the link below and also let us know if you are interested in joining our email lists.
When: Wednesday September 15th, 2021 from 6:30-7:30 pm
Where: MED Sci I, M3330 (hallway that connects med school and the hospital) or by Zoom; snacks will be provided
RSVP: https://forms.gle/WDpdQ8848UnXmS4Y7

Zoom link: https://umich.zoom.us/j/93796864104
Meeting ID: 937 9686 4104
Passcode: 223856

Go Blue,
Plastic Surgery Student Interest Group and the Society for the History and Philosophy of Medicine

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Other Wed, 08 Sep 2021 12:14:36 -0400 2021-09-15T18:30:00-04:00 2021-09-15T19:30:00-04:00 Off Campus Location The Society for the History and Philosophy of Medicine Other
U-M Food Drive for Food Gatherers (September 16, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631603@events.umich.edu Event Begins: Thursday, September 16, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-16T08:00:00-04:00 2021-09-16T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
Bringing Equity to the Forefront in Global Health (September 16, 2021 12:00pm) https://events.umich.edu/event/86029 86029-21631135@events.umich.edu Event Begins: Thursday, September 16, 2021 12:00pm
Location: Off Campus Location
Organized By: Center for Global Health Equity

What do we mean by ‘equity’ in global health? Where and how can academic institutions redefine their roles in advancing global health equity? Join us for a virtual conversation about new approaches and perspectives from communities who are directly impacted by this work. Featuring Ethiopia Minister of Health Lia Tadesse Gebremedhin, and Abebe Bekele, Dean of the School of Medicine at the University of Global Health, Rwanda.

Center Director Joseph C. Kolars and Clinical Assistant Professor of Epidemiology Ella August will facilitate the discussion with our esteemed international colleagues.

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Livestream / Virtual Tue, 31 Aug 2021 11:26:58 -0400 2021-09-16T12:00:00-04:00 2021-09-16T13:30:00-04:00 Off Campus Location Center for Global Health Equity Livestream / Virtual Featured Speakers
BME 500 Seminar: Nicholas A. Graham, Ph.D. (September 16, 2021 4:00pm) https://events.umich.edu/event/87034 87034-21638155@events.umich.edu Event Begins: Thursday, September 16, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Nicholas A. Graham, Ph.D.
Mork Family Department of Chemical Engineering and Materials Science,
University of Southern California

“Systems biology approaches to drug discovery for cancer and aging”

Abstract:

“Omics” technologies have enabled network-level measurements of genes, proteins, and metabolites from cellular models of disease. Systems biology attempts to synthesize these quantitative measurements into data-driven models to explain biological function and identify targeted therapeutic drugs. Here, I will discuss three different engineering systems biology approaches using metabolomics, proteomics, and bioinformatics to identify or discover drugs for cancer and aging. First, using metabolomics, we designed a synergistic drug combination that mimics nutrient deprivation to kill cancer cells. Second, by integrating a proteomic signature of cellular senescence with large-scale drug screening databases, we predicted and then validated that EGFR inhibitors are toxic to a model of cellular aging, specifically senescent human mammary epithelial cells. Finally, we developed a bioinformatic approach to integrate gene expression data with drug screening data from hundreds of cancer cell lines to identify clinically approved drugs whose efficacy depends on metabolic pathway activity. Taken together, these studies demonstrate how metabolomics, proteomics, and bioinformatics can all serve to identify drugs for cancer and aging.

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Lecture / Discussion Wed, 15 Sep 2021 15:08:08 -0400 2021-09-16T16:00:00-04:00 2021-09-16T17:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Event
U-M Food Drive for Food Gatherers (September 17, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631604@events.umich.edu Event Begins: Friday, September 17, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-17T08:00:00-04:00 2021-09-17T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
Opportunity Kick-Off: Preparing a Competitive NIH S10 Instrumentation Proposal (September 17, 2021 12:00pm) https://events.umich.edu/event/85468 85468-21626488@events.umich.edu Event Begins: Friday, September 17, 2021 12:00pm
Location: Off Campus Location
Organized By: OVPR Office of Research Development

Hosted by U-M Research Development and the Biosciences Initiative, this webinar will provide an overview of NIH S10 Instrumentation Grants, including U-M success rates, common reviewer critiques, a timeline for developing a strong proposal, and resources to support your efforts.
Recent S10 awardees will join our panel to discuss their experiences, offer tips for success and answer your questions.

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Workshop / Seminar Thu, 19 Aug 2021 16:59:13 -0400 2021-09-17T12:00:00-04:00 2021-09-17T13:00:00-04:00 Off Campus Location OVPR Office of Research Development Workshop / Seminar Closeup of microscope
U-M Food Drive for Food Gatherers (September 18, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631605@events.umich.edu Event Begins: Saturday, September 18, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-18T08:00:00-04:00 2021-09-18T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
U-M Food Drive for Food Gatherers (September 19, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631606@events.umich.edu Event Begins: Sunday, September 19, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-19T08:00:00-04:00 2021-09-19T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
U-M Food Drive for Food Gatherers (September 20, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631607@events.umich.edu Event Begins: Monday, September 20, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-20T08:00:00-04:00 2021-09-20T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
Machine Learning and Causality: Building Efficient, Reliable Models for Decision-Making (September 20, 2021 4:30pm) https://events.umich.edu/event/86942 86942-21637609@events.umich.edu Event Begins: Monday, September 20, 2021 4:30pm
Location: Industrial and Operations Engineering Building
Organized By: Center for Healthcare Engineering & Patient Safety (CHEPS)

Increasingly practitioners are looking to ML-based causal and predictive models to provide personalized decision guidance. However, current techniques for causal inference typically rely on having access to large amounts of data, limiting their applicability to data-constrained settings such as healthcare where collection of data might be prohibitively costly. In addition, empirical evidence has shown that most predictive models are insufficiently robust with respect to shifts at test time. This talk presents novel techniques addressing both of these problems.

Much of the causal literature focuses on learning accurate individual treatment effects, which can be complex and hard to estimate from small samples. However, it is often sufficient for clinicians to have estimates of upper and lower bounds on the potential outcomes of decision alternatives to assess risks and benefits. I will show that in such cases we can improve sample efficiency by estimating simple functions that bound these outcomes instead of estimating their conditional expectations. I will present a novel algorithm that leverages these theoretical insights.

I will also present approaches to deal with distribution shifts. I will discuss how distribution shift arises when training models to predict contagious infections in the presence of asymptomatic carriers. I will present a causally-motivated regularization scheme that enables prediction of the true infection state with high accuracy even if the training data is collected under biased test administration.

Maggie Makar is the Presidential postdoctoral fellow at the University of Michigan, and a visiting research at Microsoft Research. Dr. Makar recieved her PhD in Computer Science at MIT. While at MIT, Maggie interned at Microsoft Research, and Google Brain. Prior to MIT, Maggie worked at Brigham and Women’s Hospital, studying end-of-life care. Her work has appeared in ICML, AAAI, JSM, the Journal of the American Medical Association (JAMA), Health Affairs, and Epidemiology among others. Maggie received a B.Sc. in Math and Economics from the University of Massachusetts, Amherst.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach. For the Zoom link and password and to be added to the weekly e-mail for the series, please RSVP. For additional questions, contact CHEPSseminar@umich.edu. Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Mon, 20 Sep 2021 13:25:21 -0400 2021-09-20T16:30:00-04:00 2021-09-20T17:30:00-04:00 Industrial and Operations Engineering Building Center for Healthcare Engineering & Patient Safety (CHEPS) Lecture / Discussion Maggie Makar, Ph.D.
U-M Food Drive for Food Gatherers (September 21, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631608@events.umich.edu Event Begins: Tuesday, September 21, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-21T08:00:00-04:00 2021-09-21T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
The Futurescape of Medicine Lecture Series (September 21, 2021 10:00am) https://events.umich.edu/event/85070 85070-21625544@events.umich.edu Event Begins: Tuesday, September 21, 2021 10:00am
Location: Off Campus Location
Organized By: Osher Lifelong Learning Institute (50+)

The goal of this lecture series is to provide educational insights about future developments in five different areas of medical care.

Lecture #1 is Healthcare Financing - A Broken System in need of Repair. The speaker is Mark Frederick, MD.

Attention will be paid to current best practices, ethical implications of new technologies, promotion of consumer education and choices, and financial aspects of delivery in the context of value-based care. A lively discussion is anticipated for each lecture regarding the many issues raised by these trends and technologies.”

The series will take place every other Tuesday from 10-11:30 starting September 21. 2021, and ending November 16.

Preregistration is required via the OLLI website or phone. A link to access the lecture will be e-mailed prior to the event.

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Class / Instruction Tue, 10 Aug 2021 12:14:45 -0400 2021-09-21T10:00:00-04:00 2021-09-21T11:30:00-04:00 Off Campus Location Osher Lifelong Learning Institute (50+) Class / Instruction Futurescape of Medicine
U-M Food Drive for Food Gatherers (September 22, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631609@events.umich.edu Event Begins: Wednesday, September 22, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-22T08:00:00-04:00 2021-09-22T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
Department of Computational Medicine & Bioinformatics Weekly Seminar (September 22, 2021 4:00pm) https://events.umich.edu/event/87282 87282-21640718@events.umich.edu Event Begins: Wednesday, September 22, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

Histones are small proteins that package DNA into chromosomes, and a large number of studies have showed that several post-translational modification (PTM) sites on the histones are associated with both gene activation and silencing. Along with DNA and small non-coding RNA, histone PTMs make up epigenetic mechanisms that control gene expression patterns outside of DNA sequence mutations. Dysregulation of these chromatin networks underlie several human diseases such as cancer. Here I will give an update on technology advancements that have allowed for high-throughput quantitative analyses of histone PTMs and chromatin structure, and how we are applying these methods to understand epigenetic reprogramming found in malignant peripheral nerve sheath tumors (MPNSTs). MPNST is an aggressive sarcoma with recurrent loss of function alterations in polycomb-repressive complex 2 (PRC2), a histone-modifying complex involved in transcriptional silencing.

Zoom Link: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Mon, 20 Sep 2021 15:27:41 -0400 2021-09-22T16:00:00-04:00 2021-09-22T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual
Time Management Strategies (September 22, 2021 6:00pm) https://events.umich.edu/event/86295 86295-21632603@events.umich.edu Event Begins: Wednesday, September 22, 2021 6:00pm
Location: Off Campus Location
Organized By: Michigan Medicine Wellness Office

Are there never enough hours in the day? Learn tools, tips, and strategies to improve your time management skills. We will discuss how time management is related to stress management and how to get more control over your schedule. This session will introduce some new skills and ideas to better prioritize what needs to get done while still taking care of yourself and feeling good about your day.

Please register for zoom details
https://sessions.studentlife.umich.edu/track/event/session/45693

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Well-being Fri, 03 Sep 2021 11:30:34 -0400 2021-09-22T18:00:00-04:00 2021-09-22T19:00:00-04:00 Off Campus Location Michigan Medicine Wellness Office Well-being Wellness Office Logo
U-M Food Drive for Food Gatherers (September 23, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631610@events.umich.edu Event Begins: Thursday, September 23, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-23T08:00:00-04:00 2021-09-23T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
DCM&B Tools and Technology Seminar (September 23, 2021 12:00pm) https://events.umich.edu/event/85310 85310-21626212@events.umich.edu Event Begins: Thursday, September 23, 2021 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

This presentation will be given remotely, with the livestream available for group viewing in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

URL for remote viewing: https://umich-health.zoom.us/j/94886745590?pwd=LzhLU243K2ZhbXNzU1BJRHQ5V25BZz09

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Presentation Wed, 18 Aug 2021 09:24:07 -0400 2021-09-23T12:00:00-04:00 2021-09-23T13:00:00-04:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
Holocaust and Medicine Education for Resilient Professional Identity Formation: A Holocaust Survivor's Daughter Teaches German Medical Students at Auschwitz (September 23, 2021 12:00pm) https://events.umich.edu/event/85430 85430-21626417@events.umich.edu Event Begins: Thursday, September 23, 2021 12:00pm
Location: Off Campus Location
Organized By: The University of Michigan Medical School Program on Health, Spirituality and Religion

Dr. Hedy Wald is Clinical Professor of Family Medicine at the Alpert Medical School of Brown University and Faculty, Harvard Medical School Pediatrics Leadership Program. She is a Gold Humanism Foundation Harvard Macy Scholar, was a Fulbright Specialist Scholar in medical education for Ben Gurion University of Health Sciences, Israel, and has been a Visiting Professor at over 90 healthcare professions schools and healthcare organizations world-wide, presenting lectures and workshops on using interactive (guided) reflective writing to enhance reflective practice and support professional identity formation, promoting resilience and wellbeing, and Holocaust and Medicine in health professions education. Dr. Wald holds an appointment as a Commissioner for the international Lancet Commission on Medicine and the Holocaust.  She publishes and presents on family cancer caregiver survivorship, including for the National Cancer Policy Forum of the National Academies of Medicine in Washington, DC. Her creative writing, reviews, and poetry have appeared in literary and medical journals and her work has been cited in the Wall Street Journal, New York Times, LA Times, Chicago Tribune, Medical Independent (Ireland), and Jerusalem Post. Dr. Wald has been cited on Twitter as a medical educator to follow, on #WomeninMedicine Day as a “woman who lifts others up,” and “a voice of conscience and compassion.” Follow her on Twitter: @hedy_wald “Mind/Body/Spirit of MedEd”

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Workshop / Seminar Thu, 19 Aug 2021 08:47:58 -0400 2021-09-23T12:00:00-04:00 2021-09-23T13:00:00-04:00 Off Campus Location The University of Michigan Medical School Program on Health, Spirituality and Religion Workshop / Seminar
Alum Connection: Board Certified Plastic Surgeon, Dr. Stephen Madry (September 23, 2021 1:00pm) https://events.umich.edu/event/86918 86918-21637564@events.umich.edu Event Begins: Thursday, September 23, 2021 1:00pm
Location: Off Campus Location
Organized By: LSA Opportunity Hub

Join U-M alum Dr. Stephen Madry for a conversation designed to explore the fast-paced, high-demand world of plastic surgery. Dr. Madry will share his own professional journey, and his advice for students considering a career in health and medicine. Bring your questions about applying to medical school, determining your specialization, and building a successful career around helping people feel their best.

About Dr. Madry:
Stephen Madry, MD is a board-certified plastic surgeon in Barrington, IL just outside of Chicago. For over three decades, patients have traveled to his clinic from around the country because of Dr. Madry’s results and outstanding reputation for helping people feel their best.
Dr. Madry received his MD degree from Michigan State University in June 1989. Prior to that, he earned both his MPH degree in Epidemiology and BS in Pharmacology from the University of Michigan.
His residencies were completed at Wayne State University (General Surgery) and Loyola University (Plastic Surgery). Dr. Madry is an Associate Fellow of the American College of Surgeons and a Member of the American Society of Plastic Surgery.

You should attend this session if you are:
-A UM undergraduate LSA student interested in pursuing a career in medicine
-Interested in learning more about the medical school experience, and how you might identify your specialization
-Exploring your options for experiential learning related to careers in health and medicine

What you’ll gain by attending:
-Get advice from a U-M alum about life as a plastic surgeon
-Get helpful anecdotes and advice on preparing for and applying to medical school
-Gain access to an experienced professional who can become part of your active network

Interaction: Moderate

RSVP now to be part of the conversation. The link to join this Alum Connection will be emailed to you after you RSVP.

The LSA Opportunity Hub aims to deliver inclusive and accessible experiences and welcomes all LSA students to participate. This event will be hosted on Zoom (learn more about Zoom accessibility) and can be accessed by phone or computer. Presentation materials may be shared in advance if requested, and live captioning will be provided. To request other accommodations please contact Paige Baker at paigebak@umich.edu or 734.763.4674. so we can make arrangements.

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Workshop / Seminar Thu, 16 Sep 2021 12:04:33 -0400 2021-09-23T13:00:00-04:00 2021-09-23T14:00:00-04:00 Off Campus Location LSA Opportunity Hub Workshop / Seminar LSA Students
EIHS Symposium: Health, the Body Politic, and the Language of Recovery (September 23, 2021 4:00pm) https://events.umich.edu/event/85449 85449-21626468@events.umich.edu Event Begins: Thursday, September 23, 2021 4:00pm
Location: Tisch Hall
Organized By: Eisenberg Institute for Historical Studies

This is a hybrid event. Link here for in-person registration (limited): https://myumi.ch/yKo1N
Link here to stream via Zoom: https://myumi.ch/1p3oO

Description: We think it fitting to inaugurate our year-long theme, "Recovery," with a roundtable discussion on the language of recovery in health and medicine. It is in this context that recovery, both physical and mental, has been the focus of some of the oldest and most sustained attention and, increasingly now, critique. While recovery has still proven notoriously difficult to define, measure, and implement, with its champions and critics alike highlighting the lack of consensus on what exactly constitutes recovery, the term has at least since the 1990s come to dominate certain health sectors. This dominance is most notable in mental health policy. Within the critical medical humanities, it has become clear that the discourse of recovery is entangled in complex relations of power without being entirely fixed by them. Can recovery, despite its discontents, still have radical political potential? Is recovery itself in need of being recovered? What are the stakes in this contested sector of the body politic? Our panelists, as they explore the stakes of “recovery” from within their respective fields, will help us launch our critical engagement with recovery both as rhetoric and practice.

Panelists:
• Henry M. Cowles (Associate Professor, History, University of Michigan)
• Yi-Li Wu (Associate Professor; History, Women's and Gender Studies; University of Michigan)
• M. Remi Yergeau (Associate Professor; English Language and Literature, University of Michigan)
• Rachel Rafael Neis (moderator; Jean and Samuel Frankel Associate Professor; History, Judaic Studies; University of Michigan)

This event presented by the Eisenberg Institute for Historical Studies. It is made possible in part by a generous contribution from Kenneth and Frances Aftel Eisenberg.

Image: "Abstract," Dany Sternfeld (CC BY-NC-ND 2.0).

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Conference / Symposium Wed, 22 Sep 2021 16:20:56 -0400 2021-09-23T16:00:00-04:00 2021-09-23T18:00:00-04:00 Tisch Hall Eisenberg Institute for Historical Studies Conference / Symposium "Abstract," Dany Sternfeld (CC BY-NC-ND 2.0).
U-M Food Drive for Food Gatherers (September 24, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631611@events.umich.edu Event Begins: Friday, September 24, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-24T08:00:00-04:00 2021-09-24T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
Picture a Scientist (September 24, 2021 12:00pm) https://events.umich.edu/event/86730 86730-21639091@events.umich.edu Event Begins: Friday, September 24, 2021 12:00pm
Location: Off Campus Location
Organized By: Biostatistics

Please join us virtually on Friday, September 24th to watch and discuss the film, Picture a Scientist! This groundbreaking documentary chronicles the lives of three women scientists, who share their own experiences with sexual harassment and discrimination in order to create a more equitable and welcoming field. Watch the movie any time through this link, or join us for an online watch party at 9:30am. Then tune in at noon, to listen to a student-moderated discussion by our distinguished panel members, Dr. Patricia Coleman-Burns, Heather Colohan, Dr. Reshma Jagsi and Dr. Anna Kirkland. This will be followed by breakout room discussions (same registration as for the panel discussion) at 1:05 pm for students, staff, faculty and mixed groups.
https://sph.umich.edu/biostat/biostat_dei/biostat_dei_events/index.html

PANEL DISCUSSION (12 - 1PM ET)

Patricia W. Coleman-Burns, PhD, MA, U-M University of Michigan assistant professor emerita of nursing and Black studies. In addition to co-chairing the UM Academic Women's Caucus and serving on the U-M Women of Color in the Academy Project Steering Committee, she has served on the board of Safehouse Center on domestic violence and sexual assault. Her research, including her GENESIS pipeline project and EPIC Feedback Model, focuses on Black racial identity, workforce diversity, and reducing health disparities.

Heather Colohan, LMSW, U-M Sexual Assault Prevention and Awareness Center (SAPAC) Educator and Program Manager for Community Outreach & Systems Advocacy. She provides support and educational workshops to students, staff and faculty affected by sexual assault. She also supervises Raise the Bar; a program that works with local bars and transportation services to provide tailored workshops on sexual assault and bystander intervention.

Reshma Jagsi, MD, DPhil, Michigan Medicine Deputy Chair of Radiation Oncology, Newman Family Professor of Radiation Oncology, Residency Program Director, and Director of the Center for Bioethics and Social Sciences. Her many contributions to the study of gender discrimination in medicine include JAMA articles Gender Differences in the Salaries of Physician Researchers, and Sexual Harassment and Discrimination Experiences of Academic Medical Faculty.

Anna Kirkland, PhD, JD, U-M LSA Arthur F. Thurnau Professor of Women’s Studies, Director, Women’s and Gender Studies and School of Public Health Professor in Health Management and Policy by courtesy appointment. Prof. Kirkland served as a committee member on the National Academies panel charged with studying sexual harassment in the STEM fields of academia, published in June 2018 as Sexual Harassment of Women: Climate, Culture, and Consequences in Academic Sciences, Engineering, and Medicine.

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Lecture / Discussion Fri, 17 Sep 2021 11:10:58 -0400 2021-09-24T12:00:00-04:00 2021-09-24T13:00:00-04:00 Off Campus Location Biostatistics Lecture / Discussion Picture a scientist
U-M Food Drive for Food Gatherers (September 25, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631612@events.umich.edu Event Begins: Saturday, September 25, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-25T08:00:00-04:00 2021-09-25T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
U-M Food Drive for Food Gatherers (September 26, 2021 8:00am) https://events.umich.edu/event/86116 86116-21631613@events.umich.edu Event Begins: Sunday, September 26, 2021 8:00am
Location: North Campus Research Complex Building 18
Organized By: Michigan Medicine

In 2020, members of the U-M and local community donated more than 242,000 meals' worth of food to Food Gatherers through three food drives.

But with school restarting, pandemic unemployment benefits ending and the pandemic resurging, the need for food, diapers and toiletries continues to rise.

Michigan Medicine has launched a new food drive through Sept. 26, with in-person and online giving options. To give in person, bring food and toiletry donations to Dock 90 of the North Campus Research Complex, off Huron Parkway south of Plymouth Road. See a full list of most-needed items and other details about what can and can't be accepted: https://www.uofmhealth.org/fallfood
Or give online at https://foodgatherers.org/um

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Community Service Wed, 01 Sep 2021 11:43:59 -0400 2021-09-26T08:00:00-04:00 2021-09-26T17:00:00-04:00 North Campus Research Complex Building 18 Michigan Medicine Community Service Illustration of school bus with donated food
Understanding the Imbalance of Supply and Demand of Transplant Organs in the US: A Multidisciplinary Team Approach (September 27, 2021 4:30pm) https://events.umich.edu/event/87038 87038-21638191@events.umich.edu Event Begins: Monday, September 27, 2021 4:30pm
Location: Industrial and Operations Engineering Building
Organized By: Center for Healthcare Engineering & Patient Safety (CHEPS)

Organ donor shortage is expected to grow as demand for organs outweighs supply. However how various levers impact supply and demand of organs in the present and the future is not understood. Our team has created a framework to better understand some of the many aspects that impact supply and demand of organs to gain insights into how this issue may be ameliorated in the present and the future. Using data from various sources including Organ Procurement and Transplantation Network database, the U.S. Census Bureau and the National Health and Nutrition Examination Survey (among others), we explore how changes in donation rates (including implied consent) may impact the supply/demand imbalance.

Mariel Lavieri, Ph.D., Associate Professor of Industrial and Operations Engineering, University of Michigan
Mariel Lavieri joined the faculty at the University of Michigan - Ann Arbor in 2009. In her work, she applies operations research to healthcare topics. Her most recent research focuses on medical decision making, in particular on determining optimal monitoring and treatment by explicitly modeling stochastic disease progression.

David Hutton, Ph.D., Associate Professor School of Public Health & Industrial and Operations Engineering, University of Michigan
David Hutton holds a PhD from Stanford’s department of Management Science and Engineering with a focus on health policy modeling. David’s current research is focused on health policy and medical decision making, in particular the use of mathematical models to assist with the allocation of resources for health.

Neehar Parikh, MD, Gastroenterology, Internal Medicine, Transplant Hepatology, Michigan Medicine
Dr. Parikh’s clinical and research work focuses on treatment and outcomes for hepatobiliary malignancies. He has research interests in liver cancer treatment allocation, treatment effectiveness modeling, cost and cost-effectiveness of healthcare interventions, quality of life, liver transplantation and allocation, and cancer screening and prevention.

Luke DeRoos, Ph.D. Student, Industrial and Operations Engineering, University of Michigan
Luke DeRoos is a PhD student under the guidance of Dr. Mariel Lavieri. His research focuses on improving the quality of and access to healthcare.

Wesley J. Marrero Colón, Ph.D., Postdoctoral Research Fellow, MGH Institute for Technology Assessment, Harvard Medical School
Wesley J. Marrero Colón’s current research focuses on the usage and creation of data-driven methods to make better decisions and aims to address healthcare applications from a population and patient perspective.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach. For the Zoom link and password and to be added to the weekly e-mail for the series, please RSVP. For additional questions, contact CHEPSseminar@umich.edu. Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Mon, 20 Sep 2021 13:24:29 -0400 2021-09-27T16:30:00-04:00 2021-09-27T17:30:00-04:00 Industrial and Operations Engineering Building Center for Healthcare Engineering & Patient Safety (CHEPS) Lecture / Discussion Mariel Lavieri, Ph.D., David Hutton, Ph.D., Neehar Parikh, MD, Luke DeRoos, Ph.D. Student, Wesley J. Marrero Colón, Ph.D.
Department of Computational Medicine & Bioinformatics Weekly Seminar (September 29, 2021 4:00pm) https://events.umich.edu/event/87515 87515-21642906@events.umich.edu Event Begins: Wednesday, September 29, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

Human complex traits result from genetic and environmental factors, and from their interactions. Many of these effects are mediated by changes in gene regulation. Indeed, most genetic variants associated with complex trait variation in humans are in regulatory regions. I will present some of our recent studies on gene-environment interactions in gene regulation, with a specific focus on cardiovascular health. I will present evidence that gene-environment interactions in molecular phenotypes are frequent, account for a substantial portion of complex trait variation and modify genetic risk for disease.

Research Focus:

My lab is interested in understanding the genetic and molecular basis of inter-individual and inter-population differences in complex phenotypes. We combine evolutionary and functional genomics approaches to study intermediate phenotypes (e.g.: transcription factor binding, gene expression, protein secretion, etc.) and how they are affected by gene-environment interactions. Our research is funded by the NIH.

Zoom link: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Fri, 24 Sep 2021 14:01:53 -0400 2021-09-29T16:00:00-04:00 2021-09-29T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual Francesca Luca, PhD (Wayne State University)
How Data Science, LHS, and Precision Health Can Enhance Clinical Practice (September 30, 2021 11:00am) https://events.umich.edu/event/85706 85706-21628303@events.umich.edu Event Begins: Thursday, September 30, 2021 11:00am
Location: Off Campus Location
Organized By: Precision Health

How do we connect research findings and data to clinical care? This is the first in a series of webinars connecting health research, data, and clinical care.

Please join us to learn about the role of learning health systems (LHS) in health care and precision health (PH). Discover more about the potential role of data science in clinical practice and research within different aspects of the learning cycle. You'll also hear about opportunities and limitations of current data infrastructure (including EHR data) for precision health, and implications of using EHR to support practice change, including clinical decision support. And you'll walk away understanding dimensions of data quality and possible metrics for assessing the quality of data for particular PH questions. Finally, this is an opportunity to understand the role of data governance and (clinically oriented) learning communities in data quality and precision health research.

This webinar, led by Gretchen Piatt, Associate Professor, LHS, and Rachel Richesson, Professor, LHS, is ideal for clinicians, students in all health sciences, researchers, and those in supporting roles.

*Please use @umich.edu email to register*

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Livestream / Virtual Tue, 24 Aug 2021 16:14:39 -0400 2021-09-30T11:00:00-04:00 2021-09-30T12:00:00-04:00 Off Campus Location Precision Health Livestream / Virtual Sept. 2021 webinar
DCM&B Tools and Technology Seminar (September 30, 2021 12:00pm) https://events.umich.edu/event/85355 85355-21626295@events.umich.edu Event Begins: Thursday, September 30, 2021 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

URL for remote viewing: https://umich-health.zoom.us/j/94886745590?pwd=LzhLU243K2ZhbXNzU1BJRHQ5V25BZz09

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Presentation Wed, 18 Aug 2021 09:19:10 -0400 2021-09-30T12:00:00-04:00 2021-09-30T13:00:00-04:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
LHS Collaboratory 2021-2022 Kick-off Session (September 30, 2021 12:00pm) https://events.umich.edu/event/84725 84725-21624492@events.umich.edu Event Begins: Thursday, September 30, 2021 12:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Presentation 1
The Learning Health (Record) System

Speaker:
Philip R.O. Payne, PhD, FACMI, FAMIA, FAIMBE, FIAHSI
Janet and Bernard Becker Professor and Director, Institute for Informatics (I2), Associate Dean for Health information and Data Science, Chief Data Scientist, at Washington University in St. Louis

This presentation will explore the ways in Biomedical Data Science and Informatics research are helping to realize the potential of EHR technologies in the context of creating an LHS, from the optimization of workflow and human factors, to the generation of reproducible and systematic clinical phenotypes, to the delivery of emergent knowledge to both providers and patients via advance clinical decision support systems.

Presentation 2
Techniques and Challenges for EHR Phenotyping

Speaker:
Lisa Bastarache, MS
Research Associate Professor Department of Biomedical Informatics,
Vanderbilt University

Electronic health records (EHR) contain a wealth of real world data that can be used for research purposes. However, extracting phenotype information from EHRs can be challenging. EHR phenotyping can be divided into two types: (1) Fast phenotyping which seeks to capture a broad swath of the medical phenome, and is often accomplished using coded EHR data (e.g. billing codes) and (2) slow phenotyping that seeks to achieve high precision and recall for a single phenotype, and often uses multiple EHR data types (e.g. medications, text, lab results). This talk will describe specific use-cases for both fast and slow phenotyping, and review challenges that are commonly encountered in creating research-grade EHR phenotypes.

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Lecture / Discussion Mon, 27 Sep 2021 11:13:17 -0400 2021-09-30T12:00:00-04:00 2021-09-30T13:30:00-04:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion LHS Collaboratory Logo
EIHS Lecture: Beyond the Asylum: Mapping Circuits of Recovery and Relapse in Colonial Vietnam (September 30, 2021 4:00pm) https://events.umich.edu/event/85451 85451-21626470@events.umich.edu Event Begins: Thursday, September 30, 2021 4:00pm
Location: Tisch Hall
Organized By: Eisenberg Institute for Historical Studies

This is a hybrid event. Link here for in-person registration (limited): https://myumi.ch/QAkxr
Link here to stream via Zoom: https://myumi.ch/nbW03

Description: In colonial Vietnam, patients would spend years circulating in and out of mental asylums, defying our sense of these spaces as total institutions. This talk follows the movements of patients out of the asylum to ask what the dynamics of patient release can tell us about the varied meanings and lived experiences of recovery in a colonial society. What possibilities are opened when we shift our focus from confinement to release, from the asylum to its social world, from cure to healing?

Biography: Claire E. Edington is an associate professor of history at the University of California, San Diego, where she specializes in the history of public health, the history of modern Southeast Asia, and the colonial and postcolonial studies of science and medicine. Her first book, Beyond the Asylum: Mental Illness in French Colonial Vietnam, was published by Cornell University in 2019. She received her PhD from the Departments of Sociomedical Sciences and History from Columbia University in 2013.

This event presented by the Eisenberg Institute for Historical Studies. It is made possible in part by a generous contribution from Kenneth and Frances Aftel Eisenberg.

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Lecture / Discussion Tue, 14 Sep 2021 07:41:13 -0400 2021-09-30T16:00:00-04:00 2021-09-30T18:00:00-04:00 Tisch Hall Eisenberg Institute for Historical Studies Lecture / Discussion Claire Edington
"Medicare for All: A Citizen’s Guide" by Dr. Abdul El-Sayed (October 1, 2021 10:00am) https://events.umich.edu/event/85050 85050-21625507@events.umich.edu Event Begins: Friday, October 1, 2021 10:00am
Location: Off Campus Location
Organized By: Osher Lifelong Learning Institute (50+)

There are few issues as consequential in the lives of Americans as healthcare—and few issues more politically vexing. Every single American will interact with the healthcare system at some point in their lives, and most people will find that interaction less than satisfactory. And yet for every dollar spent in our economy, 18 cents go to healthcare. What are we paying for, exactly?

Healthcare policy is notoriously complex, but what Americans want is simple: good healthcare that's easy to use and doesn't break the bank.

Medicare for All is the leading proposal to achieve universal health coverage in America. But what is it exactly? How would it work? More importantly, is it practical or practicable?

“Medicare for All: A Citizen's Guide” goes beyond partisan talking points to offer a serious examination of how Medicare for All would transform the way we give, receive, and pay for healthcare in America.

Dr. Abdul El-Sayed is a physician, epidemiologist, educator, author, speaker, and podcast host. His newsletter, “The Incision”, cuts to the heart of the trends shaping our moment. He is a commentator at CNN. In addition to “Medicare for All” he has written “Healing Politics”, calling for a politics of empathy to cure our epidemic of insecurity. He is the host of “America Dissected,” a podcast by Crooked Media, which goes beyond the headlines to explore what really matters for our health. He is a Senior Fellow at the FXB Center for Health & Human Rights at the Harvard T. H. Chan School of Public Health, and a Scholar-in-Residence at Wayne State University and American University, teaching at the intersection of public health, public policy, and politics. He is formerly the Health Director for the City of Detroit and candidate for Governor of Michigan in 2018.

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Class / Instruction Mon, 09 Aug 2021 14:06:03 -0400 2021-10-01T10:00:00-04:00 2021-10-01T12:00:00-04:00 Off Campus Location Osher Lifelong Learning Institute (50+) Class / Instruction OLLI Reads
EIHS Workshop: Historicizing Health: Wellness, Illness, and Recovery Across Time and Space (October 1, 2021 12:00pm) https://events.umich.edu/event/85452 85452-21626473@events.umich.edu Event Begins: Friday, October 1, 2021 12:00pm
Location: Tisch Hall
Organized By: Eisenberg Institute for Historical Studies

This is a hybrid event. Link here for in-person registration (limited): https://myumi.ch/r8Mb9
Link here to stream via Zoom: https://myumi.ch/erl9p

Description: “Health,” as a historical concept, has multiple meanings. It may denote a functional body, accompanied by feelings of comfort and absence of disease. It also has mental, spiritual, and social dimensions to express the overall wellness of physical bodies in the context of everyday life and environment. Moreover, health extends beyond the individual, affecting communities and geopolitical entities. Overall, health is a dynamic process that is often represented via a graduated scale or continuous spectrum ranging from wellness and optimal functioning at one end, to disability and illness culminating in death at the other. This EIHS graduate student workshop explores the historical construction of the concept of health and related notions such as therapy, disability, and recovery. A wide range of geographical and temporal settings are considered, including Sassanian Babylonia, the Roman Empire, medieval and early modern England, and the twentieth-century United States.

Panelists:
• Grace Argo (Graduate Student, History, University of Michigan)
• Alex Burnett (Graduate Student, History, University of Michigan)
• Erin Johnson (Graduate Student, History, University of Michigan)
• Emily Lamond (Graduate Student, Ancient History, University of Michigan)
• Hannah Roussel (Graduate Student, History, University of Michigan)
• Stephie Yoon (Graduate Student, History, University of Michigan)
• Melanie S. Tanielian (moderator; Associate Professor, History, University of Michigan)

This event presented by the Eisenberg Institute for Historical Studies. It is made possible in part by a generous contribution from Kenneth and Frances Aftel Eisenberg.

Image: Skeletal Illustration, Andreas Vesalius, De Humani Corporis Fabrica, 1543, (Special Collections, University of Michigan).

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Workshop / Seminar Tue, 14 Sep 2021 07:43:06 -0400 2021-10-01T12:00:00-04:00 2021-10-01T14:00:00-04:00 Tisch Hall Eisenberg Institute for Historical Studies Workshop / Seminar Skeletal Illustration
RNA Innovation Seminar (October 4, 2021 4:00pm) https://events.umich.edu/event/86162 86162-21631753@events.umich.edu Event Begins: Monday, October 4, 2021 4:00pm
Location: 1027 E. Huron Building
Organized By: Center for RNA Biomedicine

"Fluorescent nucleoside analogues with new properties"

HYBRID EVENT
in-person: Forum Hall, Palmer Commons
Zoom: https://umich.zoom.us/webinar/register/WN__vvE2dtHQi-R3h05JUHBzQ

ABSTRACT
Fluorescent nucleoside analogues (FNAs) are powerful probes for studying the structure and dynamics of nucleic acids, which are vital to understanding RNA function, DNA damage repair, nucleic acid–protein interactions, regulatory mechanisms for gene expression, and other aspects of nucleic acid function. Existing FNAs are prone to quenching by base pairing and stacking, are clustered at the blue–green end of the visible spectrum, and have limited brightness as compared with conventional fluorophores. Studies of nucleic acid function would benefit greatly from overcoming these limitations. We have designed, synthesized, and studied a series of fluorescent pyrimidine analogues, aiming to address these limitations and develop a detailed understanding of the relationships between chemical structure and fluorescent responses to local environment in nucleic acids. Included in this series is a tricyclic cytidine analogue DEAtC that is nearly non-fluorescent as a nucleoside, but responds to matched base pairing and stacking with a fluorescence turn-on. A chlorinated tricyclic cytidine 8-Cl-tCO reports on local environment by changes in the vibrational fine structure of its emission spectra. To address the problem of limited brightness, we have design and synthesized a new NFA that we call ABN, which has a conjugated push–pull system similar to those found in bright fluorophores such as rhodamines. ABN is the brightest known FNA when present in duplex nucleic acids, and it is readily detected in single-molecule fluorescence measurements using both 1-photon and 2-photon excitation. Collectively, these FNAs offer new capabilities for biophysical studies on nucleic acids. Comparisons of their structure and properties help to reveal mechanisms for fluorescence changes in response to local environment in nucleic acids.

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Lecture / Discussion Fri, 10 Sep 2021 11:29:04 -0400 2021-10-04T16:00:00-04:00 2021-10-04T17:00:00-04:00 1027 E. Huron Building Center for RNA Biomedicine Lecture / Discussion Byron Purse, San Diego State University
Applications of Artificial Intelligence in Low-Resource Settings (October 4, 2021 4:30pm) https://events.umich.edu/event/87334 87334-21641174@events.umich.edu Event Begins: Monday, October 4, 2021 4:30pm
Location: Off Campus Location
Organized By: Center for Healthcare Engineering & Patient Safety (CHEPS)

In response to the development of new highly effective but expensive treatments, policymakers, payors, and health systems are considering novel and pragmatic ways to provide high-cost treatments to patients. One approach targets treatments using AI/ML-based approaches to those most likely to benefit (i.e., risk stratify to identify those at highest risk of complications); another is to optimize the delivery of treatment to provide high-value care while containing costs. In addition, there may be broader applicability of AI/ML-guided care in low resource settings, such as low- and middle-income countries. AI/ML can do this in a variety of settings and is exemplified in the article provided. This seminar will outline one such approach using a treatment for inflammatory bowel disease (IBD) as a use case.

Dr. Akbar K. Waljee, is a Professor in the Department of Internal Medicine Dr. Waljee serves as the Associate Director of the Data and Methods Hub and the Director of the Michigan Integrated Center for Health Analytics and Medical Prediction (MiCHAMP) both at the UM Institute for Healthcare Policy & Innovation (IHPI). He also serves as the Director of the VA CCMR Prediction Modeling Unit (PMU) and, clinically, he is the Director of the Inflammatory Bowel Disease clinic both at the VA Ann Arbor Healthcare System.

Dr. Waljee was born in Kenya and moved to the United States to complete his undergraduate and medical degrees at Emory University in Atlanta, GA. He then completed his residency and fellowship at the University of Michigan. Dr. Waljee holds a Master’s degree in Health Services Research from the University of Michigan and completed a heath care policy fellowship at the Center for Health and Research Transformation.

Dr. Waljee’s work is at the forefront of using machine learning and deep learning techniques to improve healthcare access, quality, and efficiency (high-value care) in resource constrained settings. He uses novel machine learning techniques to implement decision support systems and tools that facilitate more personalized care for disease management and healthcare utilization to ultimately deliver efficient, effective and equitable therapy for chronic diseases. To test and advance these principles, he built operational programs that are guiding—and improving—patient care in costly gastroenterology and liver disorders in under-resourced settings both domestically and abroad.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach. For the Zoom link and password and to be added to the weekly e-mail for the series, please RSVP. For additional questions, contact CHEPSseminar@umich.edu. Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Mon, 04 Oct 2021 10:32:13 -0400 2021-10-04T16:30:00-04:00 2021-10-04T17:30:00-04:00 Off Campus Location Center for Healthcare Engineering & Patient Safety (CHEPS) Lecture / Discussion Akbar Waljee, MD, MSc
Covid Vax Chat with the White House (October 4, 2021 5:30pm) https://events.umich.edu/event/87748 87748-21645526@events.umich.edu Event Begins: Monday, October 4, 2021 5:30pm
Location: Off Campus Location
Organized By: Covid Campus Coalition

Join Surgeon General Dr. Vivek Murthy and the Covid Campus Coalition in an interactive conversation about COVID-19 vaccines and college life! Ask questions and meet students from universities across the country!

About us: The Covid Campus Coalition is a national student-run effort to provide college students with accurate, timely information about the COVID-19 pandemic and vaccines. Our goal is to combat misconceptions about the COVID-19 vaccine and empower students to make fully informed decisions about their own health!

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Lecture / Discussion Thu, 30 Sep 2021 16:09:35 -0400 2021-10-04T17:30:00-04:00 2021-10-04T18:00:00-04:00 Off Campus Location Covid Campus Coalition Lecture / Discussion Event Flyer
Premed Roundup- LSA Honors Program (October 4, 2021 6:00pm) https://events.umich.edu/event/85379 85379-21626331@events.umich.edu Event Begins: Monday, October 4, 2021 6:00pm
Location: Off Campus Location
Organized By: LSA Honors Program

Hello LSA Honors Program students!

Are you considering a career in medicine or in another health care profession and wondering where to get started? If so, then we invite you to participate in an information session brought to you by Stephanie Chervin, Honors premed advisor, to learn about:

• Pre-health resources.
• Medical school course requirements.
• Timing and strategies for the long and short term.
• Choosing a major. Does it have to be in science?
• Explorations in patient and clinical exposure.
• Research opportunities.

This session will be live-virtual and you will have the chance to ask questions of the speaker. Event will be repeated on Oct. 4, 6 and 11, 2021

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Workshop / Seminar Wed, 18 Aug 2021 16:34:41 -0400 2021-10-04T18:00:00-04:00 2021-10-04T19:00:00-04:00 Off Campus Location LSA Honors Program Workshop / Seminar Doctor with a stethoscope
The Futurescape of Medicine Lecture Series (October 5, 2021 10:00am) https://events.umich.edu/event/85071 85071-21625545@events.umich.edu Event Begins: Tuesday, October 5, 2021 10:00am
Location: Off Campus Location
Organized By: Osher Lifelong Learning Institute (50+)

The goal of this lecture series is to provide educational insights about future developments in five different areas of medical care.

Lecture #2 - Current and Future Surgical Options for Hip and Knee Replacements. Brian Hallstrom is our speaker.

Attention will be paid to current best practices, ethical implications of new technologies, promotion of consumer education and choices, and financial aspects of delivery in the context of value-based care. A lively discussion is anticipated for each lecture regarding the many issues raised by these trends and technologies.”

Preregistration is required via the OLLI website or phone. A link to access the lecture will be e-mailed prior to the event.

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Class / Instruction Tue, 10 Aug 2021 12:15:40 -0400 2021-10-05T10:00:00-04:00 2021-10-05T11:30:00-04:00 Off Campus Location Osher Lifelong Learning Institute (50+) Class / Instruction Futurescape of Medicine
The Use of Cannabis for Athlete Health and Performance (October 5, 2021 1:00pm) https://events.umich.edu/event/87561 87561-21644078@events.umich.edu Event Begins: Tuesday, October 5, 2021 1:00pm
Location: Off Campus Location
Organized By: U-M Office of Research

Join the Exercise & Sport Science Initiative (ESSI) for a seminar focused on the use of cannabis for athlete health and performance. Experts will discuss how cannabis is currently regulated in sports; why medical cannabis has been proposed for use in treating chronic and acute pain, as opposed to other treatment strategies; how CBD and THC affect mental and physical health and athletic performance, both positively and negatively; the molecular mechanisms of how CBD and THC work; how THC and CBD get metabolized differently depending on how they are administered (e.g., topical, oral, or inhalation); and where the future is headed in terms of the use of medical cannabis in elite sports. Registration link: https://umich.zoom.us/webinar/register/WN_5zPjIcJbSReoX5lGuoU0hw

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Livestream / Virtual Mon, 27 Sep 2021 10:19:35 -0400 2021-10-05T13:00:00-04:00 2021-10-05T14:00:00-04:00 Off Campus Location U-M Office of Research Livestream / Virtual Athlete using CBD oil
Premed Roundup: LSA Honors Program (October 6, 2021 2:00pm) https://events.umich.edu/event/85380 85380-21626332@events.umich.edu Event Begins: Wednesday, October 6, 2021 2:00pm
Location: Off Campus Location
Organized By: LSA Honors Program

Hello LSA Honors Program students!

Are you considering a career in medicine or in another health care profession and wondering where to get started? If so, then we invite you to participate in an information session brought to you by Stephanie Chervin, Honors premed advisor, to learn about:

• Pre-health resources.
• Medical school course requirements.
• Timing and strategies for the long and short term.
• Choosing a major. Does it have to be in science?
• Explorations in patient and clinical exposure.
• Research opportunities.

This session will be live-virtual and you will have the chance to ask questions of the speaker. Event will be repeated on Oct. 4, 6 and 11, 2021

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Workshop / Seminar Wed, 18 Aug 2021 16:38:56 -0400 2021-10-06T14:00:00-04:00 2021-10-06T15:00:00-04:00 Off Campus Location LSA Honors Program Workshop / Seminar stethoscope
“This is Our Lane: talking with Patients about Racism” and “Structural Racism & the Impact on Incarcerated Midlife Women” (October 6, 2021 3:00pm) https://events.umich.edu/event/87467 87467-21642281@events.umich.edu Event Begins: Wednesday, October 6, 2021 3:00pm
Location: Off Campus Location
Organized By: Center for Midlife Science

Registration required: https://umich.zoom.us/webinar/register/WN_7wXT6ve8S2qqy4dAKi1ckA

Moderators: Sherri-Ann M. Burnett-Bowie, MD, MPH, Department of Medicine, Massachusetts General Hospital & Harvard Medical School; and Gloria Bachmann, MD, Rutgers Robert Wood Johnson Medical School.

Speakers: “This is Our Lane: talking with Patients about Racism” with Michelle S. Diop, MD, ScM, Department of Medicine, Massachusetts General Hospital & Harvard Medical School; and Sascha N. Murillo MD, Department of Medicine, Massachusetts General Hospital & Harvard Medical School; and “Structural Racism and the Impact on Incarcerated Midlife Women” with Juana Hutchinson-Colas, MD, Rutgers Robert Wood Johnson Medical School.

Location: This will be an online event. Please register for more information.

Sponsored by: Women’s Midlife Health (journal), Center for Midlife Science at the University of Michigan, Massachusetts General Hospital Department if Medicine Diversity and Inclusion Board.

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Lecture / Discussion Thu, 23 Sep 2021 17:27:30 -0400 2021-10-06T15:00:00-04:00 2021-10-06T16:00:00-04:00 Off Campus Location Center for Midlife Science Lecture / Discussion Webinar Series on Structural Racism and Midlife Health
DCM&B Tools and Technology Seminar (October 7, 2021 12:00pm) https://events.umich.edu/event/85356 85356-21626297@events.umich.edu Event Begins: Thursday, October 7, 2021 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

This presentation will be given remotely, with the livestream available for group viewing in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

URL for remote viewing: https://umich-health.zoom.us/j/94886745590?pwd=LzhLU243K2ZhbXNzU1BJRHQ5V25BZz09

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Presentation Sun, 03 Oct 2021 10:17:29 -0400 2021-10-07T12:00:00-04:00 2021-10-07T13:00:00-04:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
BME 500 Seminar: Imaging neural, hemodynamic, and cerebrospinal fluid dynamics in the sleeping brain (October 7, 2021 4:00pm) https://events.umich.edu/event/87782 87782-21645945@events.umich.edu Event Begins: Thursday, October 7, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Sleep is essential for cognition and maintenance of healthy brain function. Sleep changes diverse aspects of brain physiology, and exhibits unique behavioral states, electrophysiological oscillations, vascular dynamics, and waste clearance properties. Our research integrates multiple neuroimaging technologies to understand the neural circuits controlling sleep and the consequences of sleep for brain physiology. To investigate how these multiple aspects might be coupled during sleep, we used simultaneous fast fMRI and EEG to measure fluid and neural dynamics in the human brain. We found a coherent pattern of coupled electrophysiological, hemodynamic, and cerebrospinal fluid (CSF) dynamics that appears during non-rapid eye movement sleep. Our results demonstrate that the sleeping brain exhibits waves of CSF flow on a macroscopic scale, and suggests a neural mechanism that can regulate CSF flow. Next, using fast fMRI at ultra-high field (7 Tesla), we tracked subsecond dynamics throughout thalamocortical networks across transitions between sleep and wakefulness. We identified a temporal sequence of activity across individual thalamic nuclei that appears at the moment of awakening from sleep and predicts subsequent behaviour. Together, these studies develop multimodal imaging approaches for tracking human brain physiology at fast timescales, and identify neural and fluid dynamics unique to the sleeping brain.

Zoom Link: https://umich.zoom.us/j/97723483179

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Lecture / Discussion Mon, 04 Oct 2021 09:29:19 -0400 2021-10-07T16:00:00-04:00 2021-10-07T17:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Seminar Event
Premed Roundup: LSA Honors Program (October 11, 2021 12:00pm) https://events.umich.edu/event/85381 85381-21626333@events.umich.edu Event Begins: Monday, October 11, 2021 12:00pm
Location: Off Campus Location
Organized By: LSA Honors Program

Hello LSA Honors Program students!

Are you considering a career in medicine or in another health care profession and wondering where to get started? If so, then we invite you to participate in an information session brought to you by Stephanie Chervin, Honors premed advisor, to learn about:

• Pre-health resources.
• Medical school course requirements.
• Timing and strategies for the long and short term.
• Choosing a major. Does it have to be in science?
• Explorations in patient and clinical exposure.
• Research opportunities.

This session will be live-virtual and you will have the chance to ask questions of the speaker. Event will be repeated on Oct. 4, 6 and 11, 2021

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Workshop / Seminar Wed, 18 Aug 2021 16:42:53 -0400 2021-10-11T12:00:00-04:00 2021-10-11T13:00:00-04:00 Off Campus Location LSA Honors Program Workshop / Seminar syringe
Engineering Machine Learning for Medicine: Developing, Deploying, and Evaluating Dynamic Prediction Models (October 11, 2021 4:30pm) https://events.umich.edu/event/87726 87726-21645395@events.umich.edu Event Begins: Monday, October 11, 2021 4:30pm
Location: Industrial and Operations Engineering Building
Organized By: Center for Healthcare Engineering & Patient Safety (CHEPS)

The development, validation, and implementation of machine learning (ML) models for use in healthcare requires a strong understanding of clinical needs, analytical methods, and systems engineering. A deep dive into the development of a ML model for predicting return to work of patients experiencing occupational injuries will be used to anchor a broad discussion on engineering ML for medicine. This discussion will cover the development of a dynamic prediction model using workers compensation claims data. Additionally, we will briefly cover issues surrounding ML model task framing, validation, and implementation.

Erkin Ötleş is a Medical Scientist Training Program Fellow (MD-PhD student) at the University of Michigan. He has completed three years of medical school training and is currently a PhD candidate in the department of Industrial and Operations Engineering. His research lies at the intersection of computer science, industrial engineering, and medicine, centered on creating machine learning and artificial intelligence tools for patients, physicians, and health systems. Erkin’s dissertation work focuses on the development, implementation, and prospective usage of dynamic health outcome prediction models (e.g. early warning systems). He is co-advised by Dr. Brian Denton (Industrial and Operations Engineering) and Dr. Jenna Wiens (Computer Science and Engineering). Erkin has a professional background in health IT - having managed electronic health record development and healthcare data science teams. He holds a Master’s of Industrial Engineering from the University of Wisconsin. After completion of his MD-PhD training, Erkin plans on pursing medical residency training in emergency medicine.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach. For the Zoom link and password and to be added to the weekly e-mail for the series, please RSVP. For additional questions, contact CHEPSseminar@umich.edu. Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Mon, 04 Oct 2021 10:26:26 -0400 2021-10-11T16:30:00-04:00 2021-10-11T17:30:00-04:00 Industrial and Operations Engineering Building Center for Healthcare Engineering & Patient Safety (CHEPS) Lecture / Discussion Erkin Ötleş, MD/Ph.D. Student
Examining the Health Reform Monitoring Survey and the Well-Being and Basic Needs Survey Presented by the Urban Institute (October 12, 2021 2:00pm) https://events.umich.edu/event/87749 87749-21645527@events.umich.edu Event Begins: Tuesday, October 12, 2021 2:00pm
Location: Off Campus Location
Organized By: Inter-university Consortium for Political and Social Research

Join the Health and Medical Care Archive (HMCA) at the Inter-university Consortium for Political and Social Research (ICPSR) on October 12 at 2:00 pm EDT for a free webinar, “Examining the Health Reform Monitoring Survey and the Well-Being and Basic Needs Survey Presented by the Urban Institute” featuring Stephan Zuckerman and Michael Karpman. The webinar is hosted by HMCA, a data repository funded by the Robert Wood Johnson Foundation.

Participants will get an overview of the surveys, learn about key findings from the latest data, and discover ways these studies can be used in health research. Participants will learn about the resources available on the RWJF and HMCA websites and have the opportunity to ask questions.

Register with this link: https://myumi.ch/YyEe2

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Presentation Thu, 30 Sep 2021 16:44:15 -0400 2021-10-12T14:00:00-04:00 2021-10-12T15:00:00-04:00 Off Campus Location Inter-university Consortium for Political and Social Research Presentation Webinar Announcement with the Urban Institute and the Institute for Social Research on the Health Reform Monitoring Survey and the Well-Being and Basic Needs Survey
Department of Computational Medicine & Bioinformatics Weekly Seminar (October 13, 2021 4:00pm) https://events.umich.edu/event/86441 86441-21634316@events.umich.edu Event Begins: Wednesday, October 13, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

Understanding the genetic and molecular architecture of human disease is accelerated by robust model development and large-scale molecular profiling. I will present two studies leveraging big data analytics or automated machine learning to dissect human disease complexities: 1) Molecular and clinical signatures of SARS-CoV-2 infection in the US marines. This analysis revealed strong antiviral innate immunity set point in females contributing to sex differences in both molecular and clinical response to SARS-CoV-2 infection. A set of accurate biomarkers capable of detecting PCR false negative infections was implemented on small footprint devices. 2) Automated machine learning to interpret the effects of genetic variants. An automated framework, AMBER, was developed for efficiently searching neural network architectures to model genomic sequences. AMBER is useful in various biological applications, including fine mapping variants, partitioning genetic heritability, and in personalized medicine enabled by CRISPR/Cas9 genome editing. Together, these efforts demonstrate quantitative methods coupled with large-scale biomedical data as an effective avenue to decode human regulatory and disease biology.

Short Bio:

Frank Zhang is a Flatiron research fellow with Olga Troyanskaya at the Simons Foundation and Princeton University since 2019. Prior to that, he obtained his PhD at UCLA with Yi Xing. His research focuses on machine learning and statistical method developments for the prediction and interpretation of human molecular and genetic variations using biological big data. Recently, he works on adopting and developing cutting-edge neural architecture search methods to automate the design of deep neural networks in genomics. He is also interested in making deep learning in biomedicine more interpretable and equitable.

Zoom link: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Tue, 07 Sep 2021 14:45:38 -0400 2021-10-13T16:00:00-04:00 2021-10-13T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual
DCM&B Tools and Technology Seminar (October 14, 2021 12:00pm) https://events.umich.edu/event/85358 85358-21626298@events.umich.edu Event Begins: Thursday, October 14, 2021 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

In the Molecular Transducers of Physical Activity Consortium (MoTrPAC), we seek to understand the acute exercise response at the molecular level. In our first multi-omics dataset—a 15 tissue dataset from 6-month-old rats—there was evidence that circadian rhythms were contributing to data signatures, and thus, our ability to differentiate these circadian patterns from our primary measurement—the acute exercise response. To quantify the effects, we created distinct models for acute exercise response and circadian rhythm. We combined the models and allowed them to simultaneously compete for the percent variance explained of gene expression patterns in bulk RNA sequencing data. Analyses were performed on every gene and every tissue. Preliminary evidence suggests that our models were on the right track; for instance, the variances of many known circadian genes (in human and mouse) were primarily explained by the circadian model. However, more analyses are required to rigorously vet these models. We hope these techniques of competing models encourage others to employ similar strategies to distinguish unintended cofounding factors in experiments.

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

URL for remote viewing: https://umich-health.zoom.us/j/94886745590?pwd=LzhLU243K2ZhbXNzU1BJRHQ5V25BZz09

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Presentation Fri, 24 Sep 2021 15:26:28 -0400 2021-10-14T12:00:00-04:00 2021-10-14T13:00:00-04:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
"No Cure for Being Human with Kate Bowler" (October 18, 2021 12:00pm) https://events.umich.edu/event/85152 85152-21625637@events.umich.edu Event Begins: Monday, October 18, 2021 12:00pm
Location: Off Campus Location
Organized By: The University of Michigan Medical School Program on Health, Spirituality and Religion

The world loves us when we are good, better, best, but what about when we get sick, lose someone we love, or life hasn't turned out like we thought is should? Duke Professor Kate Bowler offers a richer understanding of hope in the face of uncertainty, despair, and suffering as we being to understand that life is a chronic condition and there is no cure for being human.

Kate Bowler is a New York Times bestselling author, host of a podcast Everything Happens, and Duke University professor. After being unexpectedly diagnosed with Stage IV cancer at age 35, she wrote Everything Happens for a Reason (and Other Lies I've Loved), which tells the story of her struggle to understand the personal and intellectual dimensions of the American belief that all tragedies are tests of character. Her latest book, No Cure For Being Human (and Other Truths I Need to Hear), grapples with her diagnosis, her ambition, and her faith as she tries to comes to terms with limitations in a culture that says anything is possible.

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Workshop / Seminar Mon, 11 Oct 2021 07:31:40 -0400 2021-10-18T12:00:00-04:00 2021-10-18T13:00:00-04:00 Off Campus Location The University of Michigan Medical School Program on Health, Spirituality and Religion Workshop / Seminar Kate Bowler, PhD
RNA Innovation Seminar: Tim Stasevich, Ph.D., Colorado State University (October 18, 2021 4:00pm) https://events.umich.edu/event/86166 86166-21631758@events.umich.edu Event Begins: Monday, October 18, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

KEYWORDS: translational regulation, gene expression, fluorescence microscopy, intrabodies, single-molecule imaging

ABSTRACT: My lab is creating technology to image mRNA translation in real time and with single-molecule precision in living cells. In this talk, I will introduce our technology and describe how it can be used to amplify fluorescence from newly synthesized proteins as they are being translated from single mRNAs. I will show how we quantify these signals to determine the size, shape, subcellular localization, and mobilities of mRNA translation sites, as well as their protein synthesis dynamics. I will then highlight a few recent applications of our technology, focusing mainly on a new biosensor we have developed to quantify how individual regulatory factors impact single mRNA translation dynamics. Using this biosensor, we provide evidence that human Argonaute2 (Ago2) shuts down translation by down regulating translation initiation on the minutes timescale and helping usher translationally silent mRNAs into P-bodies on the hours timescale. I will conclude by discussing new fluorescent intrabodies my lab is engineering to light up nascent and mature proteins in multiple colors. As these intrabodies can be encoded on plasmids, they can easily be adapted by other labs to image gene activity in diverse living systems.
Timothy J. Stasevich is an Associate Professor in the Department of Biochemistry and Molecular Biology at Colorado State University (CSU). His lab uses a combination of advanced fluorescence microscopy, genetic engineering, and computational modeling to study the dynamics of gene regulation in living mammalian cells. His lab helped pioneer the imaging of real-time single-mRNA translation dynamics in living cells1. Dr. Stasevich received his B.S. in Physics and Mathematics from the University of Michigan, Dearborn, and his Ph. D. in Physics from the University of Maryland, College Park. He transitioned into experimental biophysics as a post-doctoral research fellow in the laboratory of Dr. James G. McNally at the National Cancer Institute. During this time, he developed technology based on fluorescence microscopy to help establish gold-standard measurements of live-cell protein dynamics. Dr. Stasevich next moved to Osaka University, where he worked with Dr. Hiroshi Kimura as a Japan Society for the Promotion of Science Foreign Postdoctoral Research Fellow. While there, he helped create technology to image endogenous proteins and their post-translation modifications in vivo. This allowed him to image the live-cell dynamics of epigenetic histone modifications during gene activation for the first time2. Before joining the faculty at CSU, Dr. Stasevich spent a year as a Visiting Fellow at the HHMI Janelia Research Campus, where he applied superresolution fluorescence microscopy to improve the spatiotemporal resolution of endogenous protein imaging in live cells.
1. Morisaki, T. et al. Real-time quantification of single RNA translation dynamics in living cells. Science 352, 1425–1429 (2016).
2. Stasevich, T. J. et al. Regulation of RNA polymerase II activation by histone acetylation in single living cells. Nature 516, 272–275 (2014).

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Lecture / Discussion Thu, 30 Sep 2021 10:17:54 -0400 2021-10-18T16:00:00-04:00 2021-10-18T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Tim Stasevich, Colorado State University
The Futurescape of Medicine Lecture Series (October 19, 2021 10:00am) https://events.umich.edu/event/85073 85073-21625547@events.umich.edu Event Begins: Tuesday, October 19, 2021 10:00am
Location: Off Campus Location
Organized By: Osher Lifelong Learning Institute (50+)

The Futurescape of Medicine Lecture Series
The goal of this lecture series is to provide educational insights about future developments in five different areas of medical care.

Lecture #3 - The Role of 3D Printing in Organ Regeneration.
Our speaker is Jan Stegermann, PhD.

Attention will be paid to current best practices, ethical implications of new technologies, promotion of consumer education and choices, and financial aspects of delivery in the context of value-based care. A lively discussion is anticipated for each lecture regarding the many issues raised by these trends and technologies".

Preregistration is required via the OLLI website or phone. A link to access the lecture will be e-mailed prior to the event.

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Class / Instruction Tue, 10 Aug 2021 12:19:57 -0400 2021-10-19T10:00:00-04:00 2021-10-19T11:30:00-04:00 Off Campus Location Osher Lifelong Learning Institute (50+) Class / Instruction Futurescape of Medicine
LHS Collaboratory (October 19, 2021 12:00pm) https://events.umich.edu/event/87559 87559-21644084@events.umich.edu Event Begins: Tuesday, October 19, 2021 12:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Unlike structured data, unstructured data are often buried within free text clinical narratives that are difficult to analyze and interpret to derive useful insights. Free text cannot be easily categorized in the same way that a structured, numerical data point can, and unstructured data often have nuances that are not easily captured or represented in structured data.

This session will cover methods and techniques for interpreting and converting unstructured text into useful research data using two related, but distinct approaches: (1) Natural Language Processing (NLP), a specialized branch of AI focused on the interpretation and manipulation of human-generated spoken or written data; and (2) information retrieval, which often underlies many search engine technologies. This session will also highlight EMERSE, an open-source information retrieval tool that has been designed to help everyday users work with the free text documents (i.e., clinical notes) in medical records that is now being adopted by other academic medical centers.

Finally, attendees will hear directly from researchers about how they have used these methods and tools to enhance their research by accessing and harnessing the power of unstructured data.

Speakers:
David A. Hanauer, MD, MS, FACMI, FAMIA
Director of MICHR Informatics Program
Associate Professor of Learning Health Sciences


BRINGING DATA TO THE PEOPLE: HOW A SECURE, SELF-SERVICE, FREE-TEXT SEARCH TOOL CAN EMPOWER CLINICAL RESEARCH TEAMS AND IMPROVE PRODUCTIVITY

VG Vinod Vydiswaran, PhD
Associate Professor of Learning Health Sciences
Associate Professor School of Information

PROMISE OF UNSTRUCTURED DATA

Discussants:
Christina Angeles, MD
Assistant Professor, Surgery (General Surgery)
Assistant Professor, Dermatology

Xu Shi, Ph.D.
CCMB Affiliate Faculty
Assistant Professor of Biostatistics, School of Public Health


Leslie Yuan, MPH
Chief Information Officer, Clinical and Translational Science
(CTSI) , University of California San Francisco

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Livestream / Virtual Mon, 27 Sep 2021 11:21:27 -0400 2021-10-19T12:00:00-04:00 2021-10-19T13:30:00-04:00 Off Campus Location Department of Learning Health Sciences Livestream / Virtual Collaboratory logo
Department of Computational Medicine & Bioinformatics Weekly Seminar (October 20, 2021 4:00pm) https://events.umich.edu/event/88315 88315-21652404@events.umich.edu Event Begins: Wednesday, October 20, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

The Ye lab is focused on harnessing the power of single cell and computational genomics to understand how immune cells sense and respond to their environment. Utilizing new experimental methods we have developed to enable multiplexed single-cell sequencing, I will describe results from sequencing 1.2M cells from ~250 samples to understand the cellular and molecular bases of systemic lupus erythmatosus and COVID-19. I will also describe how population scale single cell sequencing can enable dissection of the genetic architecture of gene expression and annotation of disease associated variants. Finally, I’ll touch on novel experimental workflows to further increase the throughput of single-cell genomics and for encoding orthogonal information into single-cell sequencing assays.

Research Overview:

The Ye lab is interested in how the interaction between genetics and environment affect human variation at the level of molecular phenotypes. To study these interactions, the lab couples high-throughput sequencing approaches that measure cellular response under environmental challenges with population genetics where such measurements are collected and analyzed across large patient cohorts. The lab develops novel experimental approaches that enable the large-scale collection of functional genomic data *en masse* and computational approaches that translate the data into novel biological insights. This approach is used to initially study primary human immune cells in both healthy and diseased patients to understand host pathogen interactions and its role in autoimmunity.

Zoom link: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Fri, 15 Oct 2021 14:50:45 -0400 2021-10-20T16:00:00-04:00 2021-10-20T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual
Recognizing & Understanding Imposter Syndrome (October 20, 2021 6:00pm) https://events.umich.edu/event/87828 87828-21647053@events.umich.edu Event Begins: Wednesday, October 20, 2021 6:00pm
Location: Off Campus Location
Organized By: Michigan Medicine Wellness Office

Do you ever wonder if you belong or are you afraid that you aren't talented or good enough? Do you have trouble taking credit for your accomplishments or attribute what you have achieved to luck rather than your own skills? If any of these questions resonate with you, then you may be suffering from imposter syndrome. Join us to discuss what this syndrome is, how it could be affecting you personally, and what actions you can take and habits you can form, to handle the impacts of imposter syndrome.

Please register to receive zoom link: https://sessions.studentlife.umich.edu/track/event/session/45583

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Well-being Mon, 04 Oct 2021 11:36:26 -0400 2021-10-20T18:00:00-04:00 2021-10-20T19:00:00-04:00 Off Campus Location Michigan Medicine Wellness Office Well-being Wellness Office Logo
DCM&B Tools and Technology Seminar (October 21, 2021 12:00pm) https://events.umich.edu/event/85359 85359-21626300@events.umich.edu Event Begins: Thursday, October 21, 2021 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

URL for remote viewing: https://umich-health.zoom.us/j/94886745590?pwd=LzhLU243K2ZhbXNzU1BJRHQ5V25BZz09

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Presentation Wed, 18 Aug 2021 09:43:20 -0400 2021-10-21T12:00:00-04:00 2021-10-21T13:00:00-04:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
NeuroNetwork for Emerging Therapies Mini Symposium Series: The Mind & Music (October 21, 2021 2:00pm) https://events.umich.edu/event/88351 88351-21653429@events.umich.edu Event Begins: Thursday, October 21, 2021 2:00pm
Location: Off Campus Location
Organized By: NeuroNetwork for Emerging Therapies

"Music is to the mind as air is to the body." (Plato)

The next installment of the NeuroNetwork for Emerging Therapies Mini Symposium Series explores the idea of music as the medicine of the mind, from its physical effects to the emotions it elicits. It culminates with a look at how Mott Children’s Hospital is using music therapy to bring.

When: Thursday, October 21, 2:00 PM-2:30 PM
Where: ZOOM
Register: https://michmed.org/O525W

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Lecture / Discussion Mon, 18 Oct 2021 11:24:57 -0400 2021-10-21T14:00:00-04:00 2021-10-21T14:30:00-04:00 Off Campus Location NeuroNetwork for Emerging Therapies Lecture / Discussion Flier for The Mind & Music
Jonathan Cohn: Obamacare and the Unfinished Crusade for Universal Coverage (October 22, 2021 12:00pm) https://events.umich.edu/event/85787 85787-21629000@events.umich.edu Event Begins: Friday, October 22, 2021 12:00pm
Location: Off Campus Location
Organized By: Poverty Solutions

Jonathan Cohn is a senior national correspondent at HuffPost, where he covers politics and policy. He will discuss his book, “The Ten Year War: Obamacare and the Unfinished Crusade for Universal Coverage,” which examines how the Affordable Care Act — better known as “Obamacare” — came to be, why it looks like it does, and what it has meant for average Americans. The virtual conversation is free and open to the public, and U-M students can participate as part of a one-credit course, SWK 503 Section 001.

This event is part of the annual Real-World Perspectives on Poverty Solutions fall speaker series, which introduces key issues regarding the causes and consequences of poverty featuring experts in policy and practice from across the nation, with the goal of encouraging the formation of a broad community of learners to engage in these issues together.

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Livestream / Virtual Mon, 13 Sep 2021 13:22:47 -0400 2021-10-22T12:00:00-04:00 2021-10-22T13:00:00-04:00 Off Campus Location Poverty Solutions Livestream / Virtual Real-World Perspectives on Poverty Solutions 2021 speaker series
CANCELLED: SAVE THE DATE 11th INTERNATIONAL SYMPOSIUM (October 25, 2021 10:00am) https://events.umich.edu/event/84621 84621-21631581@events.umich.edu Event Begins: Monday, October 25, 2021 10:00am
Location:
Organized By: Center for Cell Plasticity and Organ Design

With the current state of things we have decide to cancel the Save the Date for the CPOD International Symposium.

We will update you with the new details as soon as we have a new date.

Thank you for your understanding as we work to make adjustments with the safety of all participants in mind.

Questions/Comments please contact us at: organogenesis@umich.edu

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Conference / Symposium Wed, 01 Sep 2021 10:40:09 -0400 2021-10-25T10:00:00-04:00 2021-10-25T11:00:00-04:00 Center for Cell Plasticity and Organ Design Conference / Symposium CPOD Center for Cell Plasticity and Organ Design
Virtual Job Shadow Program with Dr. Verma (October 26, 2021 8:00am) https://events.umich.edu/event/88063 88063-21654240@events.umich.edu Event Begins: Tuesday, October 26, 2021 8:00am
Location: Off Campus Location
Organized By: LSA Opportunity Hub

Elective surgeries are a cornerstone of our healthcare system that is focused on increasing a patient’s well-being and quality of life. At a time when elective surgeries have been impacted significantly by the pandemic with longer waiting periods, reschedules, or even cancellations, the ability to schedule those potentially life-changing operations in advance has been compromised. Join us for a live look into an arthroscopic rotator cuff surgery as Dr. Nikhil Verma uses advanced surgical techniques to fix a tear in a rotator cuff.


About Dr. Verma   

Dr. Verma is a Sports Medicine and Shoulder physician who performs over 500 procedures per year. He specializes in the treatment of the shoulder, elbow, and knee with an emphasis on advanced arthroscopic reconstructive techniques. He is the Director of the Division of Sports Medicine and Director of the Sports Medicine Fellowship Program at Rush University Medical Center. In addition, Dr. Verma serves as a team physician for the Chicago White Sox and Chicago Bulls.


You should attend this session if you are: 

A liberal arts and/or science undergraduate student
Searching for opportunities to shadow a physician at their clinical practice
Exploring careers and specialties in medicine and healthcare
Looking to explore different medical fields from the perspective of a physician

What you’ll gain from attending:

The opportunity to watch a live surgery performed by a physician and his team using leading technology in the field
The chance to ask the physician questions about the surgery and his work more broadly
Gain insight into how the physicians are handling elective surgeries during COVID-19


RSVP today on the LSA Opportunity Network to reserve your spot to view this live surgery. Seats will be capped at 95. Once your RSVP is complete, you will receive a confirmation email with the event details and a link to access the live viewing 24 hours before the event takes place.

The LSA Opportunity Hub aims to deliver inclusive and accessible experiences and welcomes all LSA students to participate. This event will be hosted on Zoom (learn more about Zoom accessibility) and can be accessed by phone or computer. Presentation materials will be shared in advance and live captioning will be provided. To request other accommodations, or for any further questions, please contact Jordan McAdory at jcmcado@umich.edu so we can make arrangements.

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Livestream / Virtual Wed, 20 Oct 2021 15:40:01 -0400 2021-10-26T08:00:00-04:00 2021-10-26T09:00:00-04:00 Off Campus Location LSA Opportunity Hub Livestream / Virtual Surgery Stock Photo
The Trichloroethylene Metabolite S-(1,2-dichlorovinyl)-L-cysteine Suppresses Inflammatory Pathways in a Macrophage Cell Model: Implications for Immunosuppression During Pregnancy (October 26, 2021 12:00pm) https://events.umich.edu/event/88558 88558-21655081@events.umich.edu Event Begins: Tuesday, October 26, 2021 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

https://umich.zoom.us/s/95313929320

The goal of the environmental research seminar/webinar is to provide an interdisciplinary forum for sharing and critiquing research proposals and preliminary study results.

Dr. Harris is a Research Assistant Professor of Environmental Health Sciences in the School of Public Health at the University of Michigan. Dr. Harris earned his PhD in environmental toxicology from the University of Washington, where he conducted his dissertation research in male reproductive toxicology. As part of his research he helped to develop an in vitro testis cell culture model for studying male reproductive toxicants. He now studies female reproductive toxicology, using a combination of approaches including primary tissue culture models, transcriptomics and metabolomics to investigate molecular mechanisms of toxicant effects on the placenta and fetal membranes. His research aims to advance our understanding of how environmental toxicants contribute to adverse pregnancy outcomes.

https://umich.zoom.us/s/95313929320

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Lecture / Discussion Mon, 25 Oct 2021 11:02:57 -0400 2021-10-26T12:00:00-04:00 2021-10-26T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Sean Harris Oct 26 Environmental Research Webinar
Department of Computational Medicine & Bioinformatics Weekly Seminar (October 27, 2021 4:00pm) https://events.umich.edu/event/88276 88276-21652019@events.umich.edu Event Begins: Wednesday, October 27, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:
Molecular classification has transformed the diagnosis and treatment of diffuse gliomas, creating targets for precision therapies. However, timely and efficient access to molecular diagnostic methods remains difficult, causing a significant barrier to deliver molecularly-targeted therapies. We aim to develop an innovative point-of-care diagnostic screening method that provides rapid and accurate molecular classification of diffuse gliomas through artificial intelligence and optical imaging in order to improve the comprehensive care of brain tumor patients.

Bio:
Dr. Todd Hollon is a neurosurgeon and research scientist who specializes in brain tumors. He is an Assistant Professor of Neurosurgery. He completed his postdoctoral training in the UM Translational Molecular Imaging Laboratory under the supervision of Drs. Daniel Orringer and Honglak Lee. His postdoctoral work focused on the application of deep neural networks to advanced imaging methods to improve the speed and accuracy of intraoperative brain tumor diagnosis. He hopes to be part of the next generation of young scientists that uses computation and machine learning to make scientific breakthroughs.

Host: Josh Welch, PhD

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

In-Person: Forum Hall, Palmer Commons

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Livestream / Virtual Thu, 14 Oct 2021 14:26:31 -0400 2021-10-27T16:00:00-04:00 2021-10-27T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual
DCM&B Tools and Technology Seminar (October 28, 2021 12:00pm) https://events.umich.edu/event/85361 85361-21626301@events.umich.edu Event Begins: Thursday, October 28, 2021 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

URL for remote viewing: https://umich-health.zoom.us/j/94886745590?pwd=LzhLU243K2ZhbXNzU1BJRHQ5V25BZz09

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Presentation Wed, 18 Aug 2021 09:46:40 -0400 2021-10-28T12:00:00-04:00 2021-10-28T13:00:00-04:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
“Disparities in Reproductive Aging & Midlife Health between Black & White Women” and “Taking Action to Advance the Study of Race & Ethnicity” (October 28, 2021 4:00pm) https://events.umich.edu/event/87494 87494-21642885@events.umich.edu Event Begins: Thursday, October 28, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for Midlife Science

Please register for more information and Zoom link.
https://umich.zoom.us/webinar/register/WN_JiZPRVJaStK7yNbArsSubA

The webinar, hosted by the Center for Midlife Science, features papers that will appear in a special series for the journal, Women's Midlife Health.

Talk #1 “Disparities in Reproductive Aging and Midlife Health between Black and White Women: Study of Women’s Health Across the Nation (SWAN)” with Tené T. Lewis, PhD, Department of Epidemiology, Emory University; and Siobán D. Harlow, PhD, Department of Epidemiology, University of Michigan.

Talk #2: “Taking Action to Advance the Study of Race and Ethnicity: The Women’s Health Initiative (WHI)” with Shawna Follis, PhD, MS (Dept. of Medicine, Stanford Univ. School of Medicine); Monik C. Jiménez, ScD, SM, FAHA, (Harvard Medical School and T.H. Chan School of Public Health); and Lorena Garcia, MPH, DrPH, (Division of Epidemiology, Dept. of Public Health Sciences, UC Davis School of Medicine).

Moderators: Sherri-Ann M. Burnett-Bowie, MD, MPH, Department of Medicine, Massachusetts General Hospital & Harvard Medical School; and Gloria Bachmann, MD, Rutgers Robert Wood Johnson Medical School.

Sponsored by the journal, Women’s Midlife Health; Center for Midlife Science at the University of Michigan's School of Public Health; Massachusetts General Hospital Department of Medicine Diversity and Inclusion Board. SWAN is funded by the National Institute of Aging, the National Institute of Nursing Research and the Office of Research on Women's Health. WHI is funded by the National Heart, Lung and Blood Institute.

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Lecture / Discussion Fri, 24 Sep 2021 12:04:41 -0400 2021-10-28T16:00:00-04:00 2021-10-28T17:00:00-04:00 Off Campus Location Center for Midlife Science Lecture / Discussion Webinar Series on Structural Racism and Midlife Health
Trans Medicine: The Emergence and Practice of Treating Gender (October 29, 2021 12:00pm) https://events.umich.edu/event/86703 86703-21635604@events.umich.edu Event Begins: Friday, October 29, 2021 12:00pm
Location: Off Campus Location
Organized By: Institute for Research on Women and Gender

Surfacing in the mid-twentieth century, yet shrouded in social stigma, transgender medicine is now a rapidly growing medical field. In Trans Medicine (NYU Press, 2021), stef shuster makes an important intervention in how we understand the development of this field and how it is being used to “treat” gender identity today.

Drawing on interviews with medical providers as well as ethnographic and archival research, shuster examines how health professionals approach patients who seek gender-affirming care. From genital reconstructions to hormone injections, the practice of trans medicine charts new medical ground, compelling medical professionals to plan treatments without widescale clinical trials to back them up. Relying on cultural norms and gut instincts to inform their treatment plans, shuster shows how medical providers’ lack of clinical experience and scientific research undermines their ability to interact with patients, craft treatment plans, and make medical decisions. This situation defies how providers are trained to work with patients and creates uncertainty. As providers navigate the developing knowledge surrounding the medical care of trans folk, Trans Medicine offers a rare opportunity to understand how providers make decisions while facing challenges to their expertise and, in the process, have acquired authority not only over clinical outcomes, but over gender itself.

stef m. shuster is Assistant Professor of Sociology at Michigan State University. Their work on transgender healthcare has appeared in Gender & Society, Journal of Health and Social Behavior, and Social Science & Medicine.

Register: https://myumi.ch/88rbx

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Livestream / Virtual Tue, 12 Oct 2021 11:42:01 -0400 2021-10-29T12:00:00-04:00 2021-10-29T13:00:00-04:00 Off Campus Location Institute for Research on Women and Gender Livestream / Virtual Trans Medicine
First Do No Harm: Understanding the ML/AI Behind Clinical Decision Alerts (October 29, 2021 1:00pm) https://events.umich.edu/event/87783 87783-21645946@events.umich.edu Event Begins: Friday, October 29, 2021 1:00pm
Location: Off Campus Location
Organized By: Precision Health

This is the second webinar in the Precision Health series "Demystifying the Data, Processes, and Tools that Are Changing Clinical Care."

Join us for an engaging introduction to machine learning (ML) and artificial intelligence (AI) in health care. Learn the limitations of using electronic health records (EHR) and the distinctions between AI, data science, ML, and informatics. Understand the role of AI, ML, data science, and informatics, how they work together to create clinical decision alerts, and implications on practice. Learn how these models move from development to deployment.

This webinar is geared toward clinicians from all health disciplines, ML/AI health care researchers, and anyone else interested in learning more about how connecting ML/AI with health care is changing clinical care.

**Please use @umich.edu (NOT @med.umich.edu) email to register.**

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Livestream / Virtual Fri, 01 Oct 2021 15:31:27 -0400 2021-10-29T13:00:00-04:00 2021-10-29T14:00:00-04:00 Off Campus Location Precision Health Livestream / Virtual Oct. 2021 Precision Health webinar
How Can We Make a Real Difference in Healthcare? The Challenges of Implementation (November 1, 2021 4:30pm) https://events.umich.edu/event/88632 88632-21656227@events.umich.edu Event Begins: Monday, November 1, 2021 4:30pm
Location: Industrial and Operations Engineering Building
Organized By: Center for Healthcare Engineering & Patient Safety (CHEPS)

Most of us who work in OR applications in healthcare are frustrated by the fact that planners, managers and decision makers do not seem to be suitably impressed with the mathematical beauty of our models. The literature abounds with hundreds of application papers; but when we take a closer look, few of them describe implementation. The problems in the healthcare industry are generally very similar to corresponding problems in any other sector. Hospitals have staffing issues, budget constraints, purchasing decisions, scheduling, planning, etc. The differences are subtle and often related to the culture. Over the years, I have encountered many challenges and I have been able to design approaches to deal with many of them. A few years ago, I was asked to pick the five top challenges. I can easily rattle off thirty, but selecting five was itself a challenge. In this talk, I will outline my perception of the major hurdles, provide a few examples and discuss strategies for overcoming them.

Michael Carter is a Professor in the Department of Mechanical and Industrial Engineering at the University of Toronto and Founding Director of the Centre for Healthcare Engineering (in 2009). Since 1989, his research focus has been in the area of health care resource modeling. He is on the editorial board for the journals “Health Care Management Science”, “Operations Research for Health Care”, “Health Systems” and “IISE Transactions on Healthcare Systems”. In 2012, he was inducted as a Fellow of the Canadian Academy of Engineering and in 2013, he was inducted as a Fellow of INFORMS, the international society for Operations Research and Management Science. In 2018, he became a Fellow of the Canadian Academy of Health Sciences. In 2019, he won the Northrup Frye Award for Teaching Excellence from the University of Toronto Alumni Association and in 2021, he was awarded the University of Toronto “President’s Impact Award” for his contributions to improving healthcare in Canada.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach. For the Zoom link and password and to be added to the weekly e-mail for the series, please RSVP. For additional questions, contact CHEPSseminar@umich.edu. Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Mon, 25 Oct 2021 15:17:49 -0400 2021-11-01T16:30:00-04:00 2021-11-01T17:30:00-04:00 Industrial and Operations Engineering Building Center for Healthcare Engineering & Patient Safety (CHEPS) Lecture / Discussion Michael W. Carter, Ph.D., LEL, FCAE
The Futurescape of Medicine Lecture Series (November 2, 2021 10:00am) https://events.umich.edu/event/85074 85074-21625548@events.umich.edu Event Begins: Tuesday, November 2, 2021 10:00am
Location: Off Campus Location
Organized By: Osher Lifelong Learning Institute (50+)

The goal of this lecture series is to provide educational insights about future developments in five different areas of medical care.

Lecture #4 - New Approaches to the Treatment of Gynecologic Cancers.
Our speakers will be Claire Friedman, MD and Alison Schram, MD.

Attention will be paid to current best practices, ethical implications of new technologies, promotion of consumer education and choices, and financial aspects of delivery in the context of value-based care. A lively discussion is anticipated for each lecture regarding the many issues raised by these trends and technologies.”

Preregistration is required via the OLLI website or phone. A link to access the lecture will be e-mailed prior to the event.

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Class / Instruction Tue, 10 Aug 2021 12:24:12 -0400 2021-11-02T10:00:00-04:00 2021-11-02T11:30:00-04:00 Off Campus Location Osher Lifelong Learning Institute (50+) Class / Instruction Futurescape of Medicine
Bayesian models for mercury effects on multiple outcomes in the Seychelles Child Development Study (November 2, 2021 12:00pm) https://events.umich.edu/event/88561 88561-21655084@events.umich.edu Event Begins: Tuesday, November 2, 2021 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Sally W. Thurston, PhD is an Associate Professor of Biostatistics and Environmental Medicine, University of Rochester, Dept of Biostatistics and Computational Biology.

ABSTRACT: The Seychelles Child Development Study (SCDS) Main Cohort was recruited to investigate the association between prenatal mercury (Hg) exposure from maternal fish consumption and the children’s subsequent development. Multiple neurodevelopmental outcomes were measured at several discrete ages. These outcomes can be grouped into different classes or "domains", such as cognition, motor, or memory. Associations of Hg and covariates may differ across outcomes and domains. Motivated by the SCDS, I will first discuss a model for multiple outcomes at a single age under the assumption that each outcome belongs to one domain and domain memberships are known. I will then briefly describe two extensions: a model in which outcomes may have partial domain membership in more than one domain, and a longitudinal multiple outcomes model for cognition when the tests of cognition change with the age of the child.

The goal of Environmental Statistics Week is to disseminate knowledge of advanced statistical methods most relevant to environmental health research with expert-led discussions on statistical concepts.

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Lecture / Discussion Fri, 22 Oct 2021 16:34:57 -0400 2021-11-02T12:00:00-04:00 2021-11-02T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion 2021 Environmental Statistics Week
Department of Computational Medicine & Bioinformatics Weekly Seminar (November 3, 2021 4:00pm) https://events.umich.edu/event/88449 88449-21654119@events.umich.edu Event Begins: Wednesday, November 3, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract
My research group works in the area of mathematical oncology, where we use mathematical models to decipher the complex networks of reactions inside of cancer cells and interactions between cells. Immune cells use hundreds of biochemical reactions to respond to their environment, become activated, and kill cancer cells. Understanding the complexity of these reaction networks requires computational tools and mathematical models. We combine detailed, mechanistic modeling with machine learning to study these networks, better understand cancer and immune cells, and predict ways to control tumor growth. In this talk, I will present our recent work aimed at predicting the dynamics of immune cell behaviors across three scales: intracellular signaling pathways in CAR T cells, the collective behavior of a heterogeneous population of immune cells, and tumor-immune interactions at the tissue scale. Our models generate novel mechanistic insight into immune cell activation and predict the effects of immunotherapeutic strategies.


Biography
Stacey D. Finley is the Gordon S. Marshall Early Career Chair and Associate Professor of Biomedical Engineering at the University of Southern California. Dr. Finley received her B.S. in Chemical Engineering from Florida A & M University and obtained her Ph.D. in Chemical Engineering from Northwestern University. She completed postdoctoral training at Johns Hopkins University in the Department of Biomedical Engineering. Dr. Finley joined the faculty at USC in 2013, and she leads the Computational Systems Biology Laboratory. Dr. Finley has joint appointments in the Departments of Chemical Engineering and Materials Science and Quantitative and Computational Biology, and she is a member of the USC Norris Comprehensive Cancer Center. Dr. Finley is also the Founding Director of the Center for Computational Modeling of Cancer at USC. Her research is supported by grants from NSF, NIH, and the American Cancer Society.

Selected honors. 2016 NSF Faculty Early CAREER Award; 2016 Young Innovator by the Cellular and Molecular Bioengineering journal; Leah Edelstein-Keshet Prize from the Society of Mathematical Biology; Junior Research Award from the USC Viterbi School of Engineering; the Hanna Reisler Mentorship Award; 2018 AACR NextGen Star; 2018 Orange County Engineering Council Outstanding Young Engineer; Elected Fellow of the American Institute for Medical and Biological Engineering (2021)

Hosted by: Alan Boyle, PhD

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Wed, 20 Oct 2021 09:54:50 -0400 2021-11-03T16:00:00-04:00 2021-11-03T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual Stacey D. Finley, Ph.D. (USC)
DCM&B Tools and Technology Seminar (November 4, 2021 12:00pm) https://events.umich.edu/event/85368 85368-21626321@events.umich.edu Event Begins: Thursday, November 4, 2021 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

URL for remote viewing: https://umich-health.zoom.us/j/94886745590?pwd=LzhLU243K2ZhbXNzU1BJRHQ5V25BZz09

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Presentation Wed, 18 Aug 2021 14:35:23 -0400 2021-11-04T12:00:00-04:00 2021-11-04T13:00:00-04:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
What do we learn from the environmental surveillance of SARS-CoV-2 on and off campus? (November 4, 2021 12:00pm) https://events.umich.edu/event/88563 88563-21655086@events.umich.edu Event Begins: Thursday, November 4, 2021 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Chuanwu Xi, PhD, is a Professor of Environmental Health Sciences and Global Public Health in the School of Public Health, University of Michigan.

The goal of Environmental Statistics Week is to disseminate knowledge of advanced statistical methods most relevant to environmental health research with expert-led discussions on statistical concepts.

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Lecture / Discussion Fri, 22 Oct 2021 16:48:21 -0400 2021-11-04T12:00:00-04:00 2021-11-04T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion 2021 Environmental Statistics Week
Precision Health Information Session (November 4, 2021 1:00pm) https://events.umich.edu/event/88483 88483-21654244@events.umich.edu Event Begins: Thursday, November 4, 2021 1:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

The growing field of precision health seeks to tailor health care for individuals via a multidisciplinary, data-driven approach.

The new U-M Precision Health Graduate Certificate Program has arrived to educate current and future practitioners and researchers in this emerging field so they can become better equipped to customize patient care.

• Only 12 credits of graduate coursework required
• Great opportunity for graduate students to design their own plan
• Network with other precision health students and faculty at seminars and professional development workshops
• Mentoring with faculty
• The certificate is open to all graduate students enrolled at U-M.

Attend an information session to learn more.

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Presentation Wed, 20 Oct 2021 16:17:31 -0400 2021-11-04T13:00:00-04:00 2021-11-04T13:30:00-04:00 Off Campus Location Department of Learning Health Sciences Presentation research scientist, healthcare professionals and students in lab, clinic and classroom settings
"Cell cycle regulation in microbes" (November 4, 2021 4:00pm) https://events.umich.edu/event/88883 88883-21658814@events.umich.edu Event Begins: Thursday, November 4, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

BME 500 Seminar Series
Ariel Amir, Ph.D.
Applied Mathematics and Physics
Harvard University

"Cell cycle regulation in microbes"

Abstract:
Microbial cells are remarkable in their abilities to adapt to different environments while maintaining cellular homeostasis. How cells coordinate the various events within the cell cycle, notably cell division and DNA replication, remains an outstanding problem for cells of all domains of life. I will discuss our current understanding of cell cycle regulation in microbes, including recent results demonstrating a tight coupling between DNA replication and cell division in E. coli.

DATE: Thursday, November 4, 2021
TIME: 4:00-5:00 pm
ZOOM LINK: https://umich.zoom.us/j/97723483179

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Presentation Tue, 02 Nov 2021 09:04:43 -0400 2021-11-04T16:00:00-04:00 2021-11-04T17:00:00-04:00 Off Campus Location Biomedical Engineering Presentation BME Logo
How much evidence do you need? Data Science to Inform Environmental Policy During the COVID-19 Pandemic (November 5, 2021 12:00pm) https://events.umich.edu/event/88564 88564-21655087@events.umich.edu Event Begins: Friday, November 5, 2021 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Francesca Dominici, PhD, is Professor of Biostatistics at the Harvard T.H. Chan School of Public Health and Co-Director of the Data Science Initiative at Harvard University.

The goal of Environmental Statistics Week is to disseminate knowledge of advanced statistical methods most relevant to environmental health research with expert-led discussions on statistical concepts.

Registration required. https://umich.zoom.us/s/96276431694

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Lecture / Discussion Thu, 04 Nov 2021 13:50:04 -0400 2021-11-05T12:00:00-04:00 2021-11-05T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion 2021 Environmental Statistics Week
RNA Innovation Seminar (November 8, 2021 4:00pm) https://events.umich.edu/event/86167 86167-21631759@events.umich.edu Event Begins: Monday, November 8, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

"Harnessing diverse compact CRISPR-Cas3 for long-range genome engineering"
Zhonggang Hou, Ph.D.
Research Investigator
Biological Chemistry

and

"Microscopic Examination of Spatial Transcriptome through Seq-Scope"
Jun Hee Lee, PhD
Associate Professor
Molecular & Integrative Physiology

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Lecture / Discussion Mon, 25 Oct 2021 13:33:17 -0400 2021-11-08T16:00:00-05:00 2021-11-08T20:00:00-05:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Zhonggang Hou, Biological Chemistry & Jun Hee Lee, Molecular & Integrative Physiology
Engineering Solutions to Surgical Pain Management (November 8, 2021 4:30pm) https://events.umich.edu/event/88705 88705-21656857@events.umich.edu Event Begins: Monday, November 8, 2021 4:30pm
Location: Industrial and Operations Engineering Building
Organized By: Center for Healthcare Engineering & Patient Safety (CHEPS)

Opioid prescribing for pain after surgery is a common practice in western medicine. These medications are an important tool for pain management, however excessive opioid prescribing, especially after surgery, can lead to long-term dependence and medication diversion in our communities. This is a dangerous trend that has contributed to the rise of the opioid epidemic in the United States. Dr. Englesbe and Alex Hallway have spent the last 5 years studying these trends and developing solutions to reduce excessive opioid prescribing in acute care. This talk details their efforts to improve practice at a local and state level through policy, innovation, and interdisciplinary collaboration.

Alex Hallway is a Research Area Specialist affiliated with the Michigan Opioid Prescribing Engagement Network and the Michigan Surgical Quality Collaborative (MSQC). Alex studied Human Biology and Supply Chain Management at Michigan State University. He has worked on patient care and quality improvement initiatives at Michigan Medicine since 2017. As the Pain-control Optimization Pathway Lead, Alex works with Blue Cross Blue Shield of Michigan and the MSQC to promote surgical pain control innovation in Michigan hospitals. Alex also leads the MSQC Prehabilitation program, which aims to collect novel preoperative data elements and optimize patient health prior to surgery. Alex is passionate about surgical process optimization using technology and lean thinking. He enjoys working at the intersection of quality improvement and research and has published his work in journals such as JAMA Surgery, The Journal of the American College of Surgeons, and JAMA Network OPEN.

Michael Englesbe, MD, FACS is the Cyrenus G. Darling Sr., MD and Cyrenus G. Darling Jr., MD Professor of Surgery at the University of Michigan in the Section of Transplantation Surgery. Dr. Englesbe received his undergraduate degree at Yale University in New Haven, Connecticut in 1993. He went on to obtain his medical degree in 1997 from the Robert Wood Johnson Medical School and completed his general surgery residency at the University of Michigan Health System in 2004. From 2000 to 2002, Dr. Englesbe did a surgical research post-doctoral fellowship at the University of Washington Medical Center in Seattle, Washington. Dr. Englesbe specializes in kidney and liver transplantation in adults and children. He has a specific expertise in portal hypertension in children and adults.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach. For the Zoom link and password and to be added to the weekly e-mail for the series, please RSVP. For additional questions, contact CHEPSseminar@umich.edu. Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Wed, 27 Oct 2021 11:44:51 -0400 2021-11-08T16:30:00-05:00 2021-11-08T17:30:00-05:00 Industrial and Operations Engineering Building Center for Healthcare Engineering & Patient Safety (CHEPS) Lecture / Discussion Alexander K. Hallway and Mike Englesbe, MD
Per- and Polyfluoroalkyl Substances (PFAS) and Women’s Reproductive Health: Findings from the Study of Women’s Health Across the Nation (SWAN) (November 9, 2021 12:00pm) https://events.umich.edu/event/88884 88884-21658815@events.umich.edu Event Begins: Tuesday, November 9, 2021 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

https://umich.zoom.us/s/97831201308

Dr. Ding is a postdoctoral research fellow focusing on environmental epidemiology in the Department of Epidemiology, School of Public Health, University of Michigan.

The goal of the environmental research seminar/webinar is to provide an interdisciplinary forum for sharing and critiquing research proposals and preliminary study results.

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Lecture / Discussion Tue, 02 Nov 2021 10:04:20 -0400 2021-11-09T12:00:00-05:00 2021-11-09T12:50:00-05:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Ning Ding ER Seminar (11-09-2021)
Veterans Week Special: How the Wars in Iraq and Afghanistan Impacted Military and Civilian Critical Care (November 9, 2021 6:00pm) https://events.umich.edu/event/88857 88857-21658649@events.umich.edu Event Begins: Tuesday, November 9, 2021 6:00pm
Location: Off Campus Location
Organized By: Veteran and Military Services

During this interactive session, Dr. Ward will discuss some of the medical innovations spurred by the wars in Iraq and Afghanistan, how civilian trauma care has been impacted by military medical advancements, and the future of critical care.
This event is free, and we welcome all members of the University of Michigan Medical School and larger university community including students, faculty, and staff.

Kevin Ward, MD, is a Professor of Emergency Medicine, a Lieutenant Colonel in the U.S. Army Reserve Medical Corps, founder of the Michigan Center for Integrative Research in Critical Care (MCIRCC), and Executive Director of Michigan Medicine’s Fast Forward Medical Innovation (FFMI), 2013-2018

NextGen Med is a group of medical students committed to inviting local and global leaders to discuss current challenges in medicine with the UMMS community. Questions? NextGenMed@umich.edu

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Lecture / Discussion Mon, 01 Nov 2021 13:59:33 -0400 2021-11-09T18:00:00-05:00 2021-11-09T19:00:00-05:00 Off Campus Location Veteran and Military Services Lecture / Discussion Dr. Kevin Ward
Health Policy Research Using CVFS/ISER-N Infrastructure (November 10, 2021 2:00pm) https://events.umich.edu/event/85337 85337-21626250@events.umich.edu Event Begins: Wednesday, November 10, 2021 2:00pm
Location: Off Campus Location
Organized By: Institute for Social Research

This webinar series on the Chitwan Valley Family Study (CVFS) is about global and comparative population research. Sessions include measuring mental health, Covid-19, linking data, genetics, & migrant data.

Webinar 5: Health Policy Research Using CVFS/ISER-N Infrastructure
Wednesday, November 10, 2021
2-3pm EDT
Presenter: Yubraj Acharya

The webinar is targeted to doctoral students and junior researchers in development economics/health economics intending to conduct their research using the CVFS/ISER infrastructure. I will share experience from a recent field experiment among health workers, focusing on resources on research administration available at ISER. There will be a Q&A session after the presentation.

The webinar will be hosted using Zoom. Registration is required to attend the webinar. Support provided by NICHD (R25 HD101358).

Registration is required for this event: https://umich.zoom.us/meeting/register/tJMrc-upqj4pHtKxK1qRZWxg3TDlfFgZn_xM

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Presentation Tue, 17 Aug 2021 14:30:12 -0400 2021-11-10T14:00:00-05:00 2021-11-10T15:00:00-05:00 Off Campus Location Institute for Social Research Presentation Nepal mountains
26th Annual Raymond W. Waggoner Lecture on Ethics and Values in Medicine (November 10, 2021 4:00pm) https://events.umich.edu/event/87917 87917-21647690@events.umich.edu Event Begins: Wednesday, November 10, 2021 4:00pm
Location: Off Campus Location
Organized By: Department of Psychiatry

Speaker:
Katrina Armstrong, M.D., MS
Physician-in-Chief, Massachusetts General Hospital
Jackson Professor of Clinical Medicine, Harvard Medical School

In her lecture, Dr. Armstrong will address:
Understanding the mechanisms driving the striking racial and ethnic disparities in COVID-19 is important for informing our response to the pandemic and efforts to address health equity moving forward.

No need to pre-register - just join via zoom: https://umich.zoom.us/j/93626524965?pwd=OVVOOU5rUS9vSTRNOStGanJYZktBQT09

About Katrina Armstrong, M.D.:
Katrina A. Armstrong, MD is the Jackson Professor of Clinical Medicine at Harvard Medical School, Chair of the Department of Medicine and Physician-in-Chief of Massachusetts General Hospital. She is an internationally recognized investigator in medical decision making, quality of care, and cancer prevention and outcomes, an award winning teacher, and a practicing primary care physician. She has served on multiple advisory panels for academic and federal organizations and has been elected to the American Society of Clinical Investigation and the Institute of Medicine. Prior to coming to Mass General, she was the Chief of the Division of General Internal Medicine, Associate Director of the Abramson Cancer Center and Co-Director of the Robert Wood Johnson Clinical Scholars Program at the University of Pennsylvania.

CEU information:
The University of Michigan Medical School is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. The University of Michigan Medical School designates this live activity for a maximum of 1.5 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

For further information, please contact:
Debra A. Pinals, M.D., dpinals@med.umich.edu
or
Sandra Bigler, Program Manager, University of Michigan Department of Psychiatry, sabigler@med.umich.edu, phone: 734-647-8762

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Lecture / Discussion Tue, 05 Oct 2021 12:59:36 -0400 2021-11-10T16:00:00-05:00 2021-11-10T17:30:00-05:00 Off Campus Location Department of Psychiatry Lecture / Discussion Katrina A. Armstrong, M.D.
Department of Computational Medicine & Bioinformatics Weekly Seminar (November 10, 2021 4:00pm) https://events.umich.edu/event/88540 88540-21654960@events.umich.edu Event Begins: Wednesday, November 10, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

Subspace classifiers have been around for a long time, beginning with feature selection, which in essence was a subspace selection technique. This talk will discuss the kind of subspace classifiers that Bledsoe and Browning presented in their 1959 paper and from which there have been a variety of extensions which we will discuss.

The Bledsoe and Browning subspace classifier quantizes measurement space. Each quantized observation tuple corresponds to a cell in measurement space. A collection of subspaces are selected at random. In the original form the subspaces were mutually exclusive. For each class, each cell of a subspace contained a number dependent on the number of observations of the training data that fell into that cell. For each class those numbers were combined in ways not dissimilar to random forests. For a given observation tuple, the class with the highest vote count was selected as the assigned class.

We will discuss a variety of principled extensions of the technique and make some comparisons with Neural Networks.

Research Interests:

High-dimensional space clustering, pattern recognition, knowledge discovery and artificial intelligence

Professor Haralick began his work as one of the principal investigators of the NASA ERTS satellite data doing remote sensing image analysis.

He has made a series of contributions in the field of computer vision. In the high-level vision area, he has worked on inferring 3D geometry from one or more perspective projection views.] He has also identified a variety of vision problems which are special cases of the consistent labeling problem. His papers on consistent labeling, arrangements, relation homomorphism, matching, and tree search translate some specific computer vision problems to the more general combinatorial consistent labeling problem and then discuss the theory of the look-ahead operators that speed up the tree search. The most basic of these is called Forward Checking. This gives a framework for the control structure required in high-level vision problems. He has also extended the forward-checking tree search technique to propositional logic.

Zoom: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Fri, 22 Oct 2021 09:28:27 -0400 2021-11-10T16:00:00-05:00 2021-11-10T17:00:00-05:00 Off Campus Location DCMB Seminar Series Livestream / Virtual Robert M. Haralick, PhD (City University of New York)
DCM&B Tools and Technology Seminar (November 11, 2021 12:00pm) https://events.umich.edu/event/85369 85369-21626322@events.umich.edu Event Begins: Thursday, November 11, 2021 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

Tool link: https://prsweb.sph.umich.edu/

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

URL for remote viewing: https://umich-health.zoom.us/j/94886745590?pwd=LzhLU243K2ZhbXNzU1BJRHQ5V25BZz09

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Presentation Wed, 18 Aug 2021 14:40:06 -0400 2021-11-11T12:00:00-05:00 2021-11-11T13:00:00-05:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
Hub Workshop: Alternative career ideas to white coat medicine (November 11, 2021 2:00pm) https://events.umich.edu/event/85125 85125-21625596@events.umich.edu Event Begins: Thursday, November 11, 2021 2:00pm
Location: Off Campus Location
Organized By: LSA Opportunity Hub

Are you on a pre-med track as a health or science major but are unsure if you want to pursue medical school? Join an Internship Program Coordinator for an advice-laden discussion on career prospects outside the clinic and finding, applying, and securing an internship in healthcare and public health fields. We will explore careers in the healthcare and science fields that do not require a medical degree and do not include research or teaching. We also cover strategies for entering the healthcare field through certifications. The small group setting will allow plenty of time for discussion—so bring your questions!

You should attend this workshop if you are:
A liberal arts and/or sciences (LSA) student
In a health or science academic background but are interested in pivoting away from medical school
Exploring alternative career paths to medical school that do not include research or teaching
Seeking experiential learning opportunities in healthcare and science

What you’ll gain by attending:
Learn how to effectively search for alternative careers in healthcare
Find out what types of experiences add value to your undergraduate and career journeys
Explore alternative ways to gain exposure to opportunities that do not require medical school

High Interaction
Video and audio presence is strongly encouraged
The event will mainly be interactive through some combination of full-group interactions, small-group interactions, worksheets, and Q&As.

RSVP now to reserve your spot as this small group will be capped to allow for sharing and discussion. The link to join this small group will be emailed to you 24 hours before the event.

The LSA Opportunity Hub aims to deliver inclusive and accessible experiences and welcomes all LSA students to participate. This event will be hosted on Zoom and can be accessed by phone or computer. Presentation materials may be shared in advance if requested, and live captioning will be provided. To request other accommodations please contact Anna Colvin at ancolvin@umich.edu so we can make arrangements.

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Workshop / Seminar Thu, 28 Oct 2021 12:26:19 -0400 2021-11-11T14:00:00-05:00 2021-11-11T15:00:00-05:00 Off Campus Location LSA Opportunity Hub Workshop / Seminar Alternative Careers to Medicine
"Diet and metabolic therapeutics in cancer metabolism" (November 11, 2021 4:00pm) https://events.umich.edu/event/89035 89035-21660280@events.umich.edu Event Begins: Thursday, November 11, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

BME 500 Seminar Series
Jason Locasale, Ph.D.
Pharmacology and Cancer Biology
Duke University

"Diet and metabolic therapeutics in cancer metabolism"
Abstract:
This presentation will focus on methionine metabolism in health and cancer. I will first
discuss methionine content in human food and dietary patterns . I will next focus on
how changes to dietary methionine can produce defined consequences on cellular
metabolism. I will then discuss work on dietary influences on the activity of the
pathway and its relation to the regulation of one carbon metabolism in cancer. How
methionine restricted diets may allow for interventions in cancer treatment and relevant
mechanisms will be discussed including how changes to dietary methionine can
influence interventions that target one carbon metabolism involving radiation and
antimetabolite chemotherapies such as 5-fluorouracil. The link between nutritional
methionine status and chromatin biology and epigenetics will also be introduced in this
talk.
Details:
DATE: Thursday, November 11, 2021
TIME: 4:00-5:00 pm
ZOOM LINK: https://umich.zoom.us/j/97723483179

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Presentation Mon, 08 Nov 2021 10:30:52 -0500 2021-11-11T16:00:00-05:00 2021-11-11T17:00:00-05:00 Off Campus Location Biomedical Engineering Presentation BME Event
Veterans Week: VA Healthcare and Benefits Discussion (November 12, 2021 12:00pm) https://events.umich.edu/event/78641 78641-21654783@events.umich.edu Event Begins: Friday, November 12, 2021 12:00pm
Location: Off Campus Location
Organized By: Veteran and Military Services

Come with questions about VA Healthcare and VA Benefits!
Ann Arbor is lucky to have one of the best VA healthcare systems in the country as our next-door neighbor. In fact, many of the healthcare professionals at the Ann Arbor VA also work for U-M! U-M Ann Arbor is one of the only campuses in the country with VA Healthcare and VA Benefits specialists embedded on our campus through our VITAL and VSOC programs. Jon and Brittany will discuss their roles on campus, their roles and knowledge about the VA and answer your questions about this vital resource to our student, staff, faculty and community members who have served.

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Lecture / Discussion Thu, 21 Oct 2021 19:09:04 -0400 2021-11-12T12:00:00-05:00 2021-11-12T13:00:00-05:00 Off Campus Location Veteran and Military Services Lecture / Discussion VA logo
Disabusing Disability™: Demonstrating That DISability Doesn’t Mean INability (November 15, 2021 4:30pm) https://events.umich.edu/event/89183 89183-21660946@events.umich.edu Event Begins: Monday, November 15, 2021 4:30pm
Location: Industrial and Operations Engineering Building
Organized By: Center for Healthcare Engineering & Patient Safety (CHEPS)

Disability is regularly neglected in conversations about diversity, equity, and inclusion, yet it is the one demographic that we may all identify with one day. Therefore, disability should serve as a means of demonstrating that we are all much more similar than we are different. As a disabled, black, Nigerian, immigrant, cis-gender heterosexual, male, physician, athlete this presentation will talk about the intersectionality between all of those identities, striving to demonstrate that disability is not inability, and encouraging us to allow people to demonstrate what they can do, rather than attempting to limit them based on what they cant. It will also hope to engage you all in conversation about what each of us can do, within our own spheres of influence to make sure we are not perpetuating ableism in our personal, academic, and professional lives.

Dr. Oluwaferanmi Okanlami is an Assistant Professor of Family Medicine, Physical Medicine & Rehabilitation, and Urology at Michigan Medicine, an Adjunct Assistant Professor of Orthopaedic Surgery at David Geffen School of Medicine at UCLA, and the Director of Student Accessibility and Accommodation Services at the University of Michigan, where he oversees the office of Services for Students with Disabilities, two Testing Accommodation Centers, and the Adaptive Sports & Fitness Program. He also serves as the Spokesperson for Guardian Life in their Equal & Able Partnership.

“Dr. O” was born in Nigeria before immigrating to the US at a young age. He attended High School at Deerfield Academy and college at Stanford University where he also ran Track & Field, serving as captain his last two seasons and achieving Academic All American recognition.

He then earned his MD from the University of Michigan before matching into Orthopedic Surgery at Yale. At the beginning of his 3rd year, he experienced a spinal cord injury, paralyzing him from the chest down. After two surgeries and intense rehabilitation, he was blessed with some return of motor function, and navigates the world as a proud wheelchair user, managing the other long-term sequelae of an incomplete cervical spinal cord injury.

He went on to earn a Master’s in Engineering, Science, and Technology Entrepreneurship from The University of Notre Dame, and completed his Family Medicine Residency at Memorial Hospital in South Bend, Indiana. He served on the St. Joseph County Board of Health, appointed by (former South Bend Mayor, and current Secretary of the Department of Transportation) Pete Buttigieg; and is on the board of the River City Challenged Athletes, a non-profit supporting the area adaptive sports teams. He was featured on Robin Robert’s Good Morning America Series “Thriver Thursday,” and has a catchphrase, “Disabusing Disability®,” hoping to demonstrate that DISability doesn’t mean INability. He is a member of the Alpha Omega Alpha Medical Honors Society, received Michigan Medicine’s Distinguished Early Career Alumni Award in 2020, and was given the “A Teacher’s Teacher Award’’ by the Academy of Medical Educators.

Nationally, he serves as the Disability Issues representative on the Steering Committee for the Group on Diversity and Inclusion at the AAMC, and sits on the National Medical Association’s Council on Medical Legislation. He speaks around the country on topics related to Diversity, Equity, and Inclusion, including, but not limited to creating a health system that is accessible to and inclusive of both patients and providers with disabilities, and providing reasonable and appropriate accommodations for students with disabilities in higher education. He has been featured on CBS News, PBS News Hour, and MSNBC’s Morning Joe, and is passionate about adaptive sports and fitness, striving to provide access to physical fitness and inclusive recreational and competitive sports for all.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach. For the Zoom link and password and to be added to the weekly e-mail for the series, please RSVP. For additional questions, contact CHEPSseminar@umich.edu. Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Thu, 11 Nov 2021 16:13:02 -0500 2021-11-15T16:30:00-05:00 2021-11-15T17:30:00-05:00 Industrial and Operations Engineering Building Center for Healthcare Engineering & Patient Safety (CHEPS) Lecture / Discussion Oluwaferanmi O. Okanlami, M.D., M.S.
Michigan Institute of Data Science Annual Symposium (November 16, 2021 9:00am) https://events.umich.edu/event/88888 88888-21658824@events.umich.edu Event Begins: Tuesday, November 16, 2021 9:00am
Location: Michigan League
Organized By: Michigan Institute for Data Science

Workshops

Sign up to attend one of the four mini-workshops as part of the 2021 U-M Data Science and AI Symposium. Bring your own laptop!

Nov. 16th | 9:00am - 11:00am @ Michigan League

1. Introduction to data visualization on the web with D3.js. Led by Prof. Fred Feng (Industrial and Manufacturing Systems Engineering)

2. Using text as data: Introduction to machine learning for natural language processing. Led by Drs. Jule Krueger (Institute for Social Research) and Meghan Dailey (Advanced Research Computing)

3. Diversity and equity in data science - a community forum. Led by Drs. Lia Corrales (Astronomy), Tayo Fabusuyi (U-M Transportation Research Institute), H. V. Jagadish (MIDAS Director), and Rada Mihalcea (U-M AI Lab Director). Presenters will highlight technical designs to detect and adjust for data and algorithmic biases, and programs that promote diversity in data science and AI research community. Attendees will be encouraged to share their work and discuss ways to collaborate.

4. Developing best practices for reproducible data science. Led by Drs. Jing Liu (MIDAS Managing Director), Johann Gagnon-Bartsch (Statistics), Tom Valley (Internal Medicine) and Sharon Glotzer's Lab. The presenters will offer tutorials on building reproducible workflows, data and code review and sharing. They will also answer questions for those who are interested in entering the MIDAS 2021 Reproducibility Challenge.

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Workshop / Seminar Tue, 02 Nov 2021 10:48:50 -0400 2021-11-16T09:00:00-05:00 2021-11-16T11:00:00-05:00 Michigan League Michigan Institute for Data Science Workshop / Seminar MIDAS Symposium 2021
The Futurescape of Medicine Lecture Series (November 16, 2021 10:00am) https://events.umich.edu/event/85075 85075-21625549@events.umich.edu Event Begins: Tuesday, November 16, 2021 10:00am
Location: Off Campus Location
Organized By: Osher Lifelong Learning Institute (50+)

The Futurescape of Medicine Lecture Series
The goal of this lecture series is to provide educational insights about future developments in five different areas of medical care.

Lecture #5 - Advances in Depression Research and Treatment: Now and For the Future. Our speaker is John F. Greden M.D.

Attention will be paid to current best practices, ethical implications of new technologies, promotion of consumer education and choices, and financial aspects of delivery in the context of value-based care. A lively discussion is anticipated for each lecture regarding the many issues raised by these trends and technologies.”

Preregistration is required via the OLLI website or phone. A link to access the lecture will be e-mailed prior to the event.

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Class / Instruction Tue, 10 Aug 2021 12:28:30 -0400 2021-11-16T10:00:00-05:00 2021-11-16T11:30:00-05:00 Off Campus Location Osher Lifelong Learning Institute (50+) Class / Instruction Futurescape of Medicine
DCMB / CCMB Weekly Seminar Series (November 17, 2021 4:00pm) https://events.umich.edu/event/89137 89137-21660643@events.umich.edu Event Begins: Wednesday, November 17, 2021 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Talk title: Clinical Trajectory analysis to determine risk-factors of Copd: A COPDGene Study

Abstract:

Background

Chronic obstructive pulmonary disease (COPD) presents significant clinical heterogeneity and a wide variety of progression trajectories [1]. Clinical trajectory analysis (ClinTrajAn) is a powerful tool based on elastic principal graphs for the calculation of trajectories from large cross-sectional clinical data sets [2].

Aims and objectives

Our objective was to determine potential risk-factors by evaluate progression trajectories in COPD using ClinTrajAn on the COPDGene Phase I (baseline visit) dataset.

Methods

7883 participants, current and former smokers with GOLD 0 thru 4 COPD, from Phase I of the COPDGene study, were utilized for this work. 55 features were obtained for each subject, including demographics, spirometry, smoking history and computed tomography (CT), which included Parametric Response Mapping (PRM). Developed by our group, PRM is capable of simultaneously measuring small airways disease and emphysema which are the main contributors of airflow limitations in COPD. The resulting data matrix was analyzed with ClinTrajAn.

Results

A principal tree, with 13 branch segments and 8 termini, was generated (Figure 1). There was a clearly recognized trajectory from healthier subjects through decreasing lung function and increasing age (Figure 1 A), increasing in GOLD (Figure 1 B), to an emphysema high terminus (Figure 1 C). Notably this method illustrated numerous branching points along this trajectory.

Conclusions

In this study we used ClinTrajAn to obtain a map of disease progression trajectories in COPD including clinically recognized pathogenesis. Our next steps will be to further validate this approach using longitudinal data from the COPDGene follow-up visits.

References

1. Han MK, Agusti A, Calverley PM, Celli BR, Criner G, Curtis JL, Fabbri LM, Goldin JG, Jones PW, MacNee W, Make BJ. Chronic obstructive pulmonary disease phenotypes: the future of COPD. American journal of respiratory and critical care medicine. 2010 Sep 1;182(5):598-604.

2. Golovenkin SE, Bac J, Chervov A, Mirkes EM, Orlova YV, Barillot E, Gorban AN, Zinovyev A. Trajectories, bifurcations, and pseudo-time in large clinical datasets: applications to myocardial infarction and diabetes data. GigaScience. 2020 Nov;9(11):giaa128.

Zoom link: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Lecture / Discussion Wed, 10 Nov 2021 09:47:40 -0500 2021-11-17T16:00:00-05:00 2021-11-17T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
John & Margaret Faulkner Lectureship of Physiology (November 17, 2021 4:00pm) https://events.umich.edu/event/87825 87825-21647050@events.umich.edu Event Begins: Wednesday, November 17, 2021 4:00pm
Location: Off Campus Location
Organized By: Department of Molecular and Integrative Physiology

The Department of Molecular & Integrative Physiology presents the 10th Annual John & Margaret Faulkner Lectureship in Physiology.
Dr. Huda Y. Zoghbi, the Ralph D. Feigin Professor of Molecular & Human Genetics, Pediatrics, Neurology, and Neuroscience from Baylor College of Medicine, will present "Genetic and Physiological Approaches to Tackle Neurodevelopmental Disorders"

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Conference / Symposium Mon, 04 Oct 2021 10:54:38 -0400 2021-11-17T16:00:00-05:00 2021-11-17T17:00:00-05:00 Off Campus Location Department of Molecular and Integrative Physiology Conference / Symposium 10th Annual John & Margaret Faulkner Lectureship of Physiology
From Healthcare to Self-Care: Empowering Ourselves Through Well-Being, Meaning and Sustainable Behavior Change (November 17, 2021 6:00pm) https://events.umich.edu/event/87831 87831-21647056@events.umich.edu Event Begins: Wednesday, November 17, 2021 6:00pm
Location: Off Campus Location
Organized By: Michigan Medicine Wellness Office

Have you ever wondered why it is that people who desperately want to adopt physically active lifestyles don’t stick with them once their initial burst of motivation fades? This provocative presentation will showcase the science for a new paradigm to better foster sustainable behavior change. Dr. Michelle Segar will explain why logic-based reasons for behavior change (e.g., better health, disease prevention, etc.) keep people stuck in cycles of starting and stopping but not behavioral sustainability. Using a science-based story, she will describe a novel approach to promoting physical activity and other self-care behaviors that can be used across contexts (organizational, health care, fitness, coaching, etc.). Attendees will leave this session with a more strategic way to think about and promote the sustainable behavior necessary for achieving improved health and well-being.

Please register to receive zoom link: https://sessions.studentlife.umich.edu/track/event/session/45695

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Well-being Mon, 04 Oct 2021 11:39:42 -0400 2021-11-17T18:00:00-05:00 2021-11-17T19:00:00-05:00 Off Campus Location Michigan Medicine Wellness Office Well-being Wellness Office Logo
DCM&B Tools and Technology Seminar (November 18, 2021 12:00pm) https://events.umich.edu/event/85370 85370-21626323@events.umich.edu Event Begins: Thursday, November 18, 2021 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

This presentation will be given remotely, with the livestream available for group viewing in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

URL for remote viewing: https://umich-health.zoom.us/j/94886745590?pwd=LzhLU243K2ZhbXNzU1BJRHQ5V25BZz09

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Presentation Mon, 30 Aug 2021 08:08:26 -0400 2021-11-18T12:00:00-05:00 2021-11-18T13:00:00-05:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
Medical School Student Panel Discussion (November 18, 2021 3:30pm) https://events.umich.edu/event/85497 85497-21626705@events.umich.edu Event Begins: Thursday, November 18, 2021 3:30pm
Location: Off Campus Location
Organized By: Science Learning Center

Here is your chance to hear about what life is like for several medical school students and residents. Learn about each of their paths to medicine, experiences in medical school, and things they wished they had known in college. You can also submit your own questions ahead of time using the following link: https://myumi.ch/2D299

Register on Sessions: https://myumi.ch/pdYmj

Email ScienceSuccessSeries@umich.edu with any questions.

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Workshop / Seminar Fri, 20 Aug 2021 11:59:04 -0400 2021-11-18T15:30:00-05:00 2021-11-18T17:00:00-05:00 Off Campus Location Science Learning Center Workshop / Seminar
Alan J. Hunt Memorial Lecture: "Moving takes energy: the intersection of cell motility with cellular metabolism" (November 19, 2021 2:00pm) https://events.umich.edu/event/89276 89276-21661669@events.umich.edu Event Begins: Friday, November 19, 2021 2:00pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: Biomedical Engineering

2021 Alan J. Hunt Memorial Lecture

"Moving takes energy: the intersection of cell motility with cellular metabolism"

Cynthia Reinhart-King, Ph.D.
Cornelius Vanderbilt Professor of Engineering
Professor of Biomedical Engineering
Vanderbilt University

November 19, 2021, 2:00 PM - 3:30 PM

Please save the date and RSVP below for the 2021 Alan J. Hunt Memorial Lecture on Friday, November 19, 2021, from 2:00 PM - 3:30 PM. The lecture will take place in 1130 Lurie Biomedical Engineering Building (classroom) featuring Cynthia Reinhart-King, Ph.D. the Cornelius Vanderbilt Professor of Engineering and Professor of Biomedical Engineering at Vanderbilt University. Following the lecture, a reception will be held in the BME Commons.

Details:
DATE: Friday, November 19, 2021
TIME: 2:00 PM - 3:30 PM (Reception; 3:30 PM - 4:30 PM)
LOCATION: 1130 Lurie Biomedical Engineering; A reception will follow in the BME Commons

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Lecture / Discussion Mon, 15 Nov 2021 15:16:23 -0500 2021-11-19T14:00:00-05:00 2021-11-19T16:30:00-05:00 Lurie Biomedical Engineering (formerly ATL) Biomedical Engineering Lecture / Discussion Alan J Hunt
Be a Hero at the Big House (November 21, 2021 8:00am) https://events.umich.edu/event/68708 68708-21659650@events.umich.edu Event Begins: Sunday, November 21, 2021 8:00am
Location: Michigan Stadium
Organized By: Wolverines for Life

Be a Hero will be returning to the Big House on Sunday, November 21st! Join us for our largest event at the Michigan Stadium. Blood donors are encouraged to donate blood at the biggest blood drive on the University of Michigan campus. Blood donations will count towards the Blood Battle competition against OSU. Attendees also have the opportunity to join the organ donor registry or be screened as a bone marrow donor. There will be entertainment, activities, giveaways, special guests, and snacks throughout the day.

Make your blood donation appointment here: https://www.redcrossblood.org/give.html/drive-results?dt=WB:PL:DR:PM&ed=11%2F21%2F2021&order=DATE&range=10&sd=11%2F21%2F2021&zipSponsor=goblue

Scheduled Entertainment
10:00 am - 12:00 pm Meet the Wolverine Trooper
10:50 am Mascot Dance-off
12:00 pm - 1:00 pm Meet our Athletic Guest, Jon Jansen
1:00 pm Watch the Detroit Lions vs. the Cleveland Browns on the suite TVs

All Day
Donate Blood
Join the organ donor registry
Join the bone marrow registry
Meet the Michigan pageant winners
Play games and participate in fun, family-friendly activities
Post something to the social media feed
Grab some cider & doughnuts
Score a free t-shirt
Enter to win one of our exciting door prizes


Interested in volunteering? We need a bunch of volunteers to help pull this event off! We're asking for help both the day of the event and the day before to help load-in. Click the sign-up links below to see how you can help!

In alignment with Michigan Medicine's policy, all Michigan Medicine volunteers must be fully vaccinated against COVID-19 in order to volunteer. To be considered fully vaccinated, you must be at least two weeks post completion of two doses of the Moderna or Pfizer vaccines, or a single dose of the Johnson & Johnson vaccine. For information on vaccines and where to access them, click here.

If you are a University of Michigan student, faculty, or staff member and have already verified your vaccine with the institution, please email a screenshot of your ResponsiBLUE screen showing that your vaccine has been “Completed” to Megan Podschlne at mpodschl@med.umich.edu if you have not already done so.
For all other volunteers, please submit your vaccine information if you have not already done so, including a picture of your vaccine card, by clicking here: https://umich.qualtrics.com/jfe/form/SV_8rkqg6yUMJLuD8G. If you have been partially vaccinated (i.e., received only 1 dose in a 2 dose series), please wait to submit this form until you have received all vaccine doses.
If you are not able to submit your information through the survey, please let us know.
Once you submit the form, vaccine information will be reviewed within the next 7 business days. If your vaccine series is not authorized by the U.S. Food and Drug Administration (FDA) or the World Health Organization (WHO), you will not be considered fully vaccinated under U-M policy. To be considered fully vaccinated you must have received all doses of the vaccine at least 2 weeks ago.

Be a Hero volunteer sign-up (11/21/2021): https://www.signupgenius.com/go/20f0e4fa8ac2fa0fb6-beahero14
Be a Hero Load-in volunteer sign-up (11/20/2021): https://www.signupgenius.com/go/20f0e4fa8ac2fa0fb6-beahero13


Would you like to share your donation or transplant story? Email Megan Podschlne at mpodschl@med.umich.edu.


Can't make it to Be a Hero? Schedule a blood drive appointment between 10/27/2021 and 11/24/2021 to help us beat OSU in the annual Blood Battle competition! Visit www.redcrossblood.org and enter sponsor code "goblue" for a list of participating drives.

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Reception / Open House Fri, 05 Nov 2021 14:31:12 -0400 2021-11-21T08:00:00-05:00 2021-11-21T17:00:00-05:00 Michigan Stadium Wolverines for Life Reception / Open House Be a Hero Digital Ad
Process Mining Approaches to Identify System-Level Factors in Maternal Health Disparities (November 22, 2021 4:30pm) https://events.umich.edu/event/88862 88862-21658653@events.umich.edu Event Begins: Monday, November 22, 2021 4:30pm
Location: Industrial and Operations Engineering Building
Organized By: Center for Healthcare Engineering & Patient Safety (CHEPS)

The US has one of the highest maternal mortality and morbidity rates among all developed countries despite spending the most on maternity care. Half of all maternal deaths, Severe Maternal Morbidity (SMM), and near-misses are preventable with timely and appropriate care. Maternal mortality and SMM from several specific conditions, such as hemorrhage and preeclampsia, have much higher rates of preventability. Socioeconomic factors have been shown to impact maternal outcomes, however, there is little research explicitly examining system-level factors such as delays, missed or late diagnoses, inadequate teamwork, delays, and poor coordination within the health system that contribute to these adverse outcomes and disparities. National and state level efforts to improve maternal care has led to the development of best practices in maternity care pathways however many challenges still exist. Examining patients’ journey through the health system will also enable us to identify, and ultimately predict, specific system features associated with adverse outcomes. This research approaches the care pathway analysis within the lens of process mining. Process mining evaluates the processes using event logs. The patient cohort consists of medical records for maternal patients who have initiated prenatal care and postpartum women with normal birth outcomes and adverse maternal outcomes. We used NIH’s “AllofUS” dataset to develop a conceptual model to map maternal patients’ interactions with the healthcare system. Process mining algorithms help us identify variability in these captured care pathways that are associated with adverse maternal outcomes. Preliminary data analysis using visualization and decision tree techniques offer insights about disparities in maternal care.

Dr. Sreenath Chalil Madathil is an Assistant Professor in the Industrial Manufacturing and Systems Engineering (IMSE) at The University of Texas at El Paso (UTEP). Before joining UTEP, he worked as research scientist at the Watson Institute of Systems Excellence at The Research Foundation of the State University of New York at Binghamton. Dr. Chalil Madathil received his Ph.D. and MS in Industrial Engineering from Clemson University. His current research interest is in applying operations research and data analytics to healthcare and supply chain domains. He is a member of the Institute of Industrial & Systems Engineers (IISE), and serves as chair for the IISE Health Systems Track. He is also a member of INFORMS, and Alpha Pi Mu.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach. For the Zoom link and password and to be added to the weekly e-mail for the series, please RSVP. For additional questions, contact CHEPSseminar@umich.edu. Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Mon, 01 Nov 2021 14:58:16 -0400 2021-11-22T16:30:00-05:00 2021-11-22T17:30:00-05:00 Industrial and Operations Engineering Building Center for Healthcare Engineering & Patient Safety (CHEPS) Lecture / Discussion Sreenath Chalil Madathil, Ph.D.
The Role of Command Centers in Health System Operations (November 29, 2021 4:30pm) https://events.umich.edu/event/89361 89361-21662306@events.umich.edu Event Begins: Monday, November 29, 2021 4:30pm
Location: Industrial and Operations Engineering Building
Organized By: Center for Healthcare Engineering & Patient Safety (CHEPS)

Hospitals nationally have struggled with the challenges of increasing demand and limited overall capacity leading to bottlenecks in care and inefficient patient flow through the hospital. Given constraints on expanding bed capacity including both high costs and regulatory barriers, hospitals have increasingly focused on improving operational efficiency as a method to improve patient flow. Michigan Medicine and UM Health have been on a journey to improve patient flow over several years through the application of engineering principles, analytics, improved management of variation, and creation of a system-wide playbook for how we approach capacity management and patient flow in our hospitals. This work has culminated in a current project to develop and implement a hospital command center as the next step in creating reliable system-wide processes to manage patient flow and safety. In this talk, I will describe our journey in hospital capacity management, walk through our playbook and principles and finish with an update on how we are planning to integrate all these lessons learned into our new hospital command center that will go live in late 2022.

Vikas I. Parekh, MD is Professor of Medicine at the University of Michigan where he is the Associate Chief Medical Officer for UM Health. As Associate Chief Medical officer, he guides the health system’s work on capacity management, readmissions and leads an operational analytics team working to optimize patient flow and operational challenges throughout the health system as lead for the multi-million-dollar Command Center project. He has published and presented nationally in the fields of hospital medicine, residency education and hospital operations and capacity management. Dr. Parekh is a graduate of the Harvard Medical School and completed his residency training at the University of Michigan. Dr. Parekh has won several awards including the Provost’s Teaching Innovation Prize, the Special Recognition Award for Contributions to the House Officer Teaching Program, the H. Marvin Pollard Award, the Department of Medicine’s highest award for resident teaching and the Chair’s Impact Award for his work during COVID-19 and was inducted into the Medical School’s League of Educational Excellence.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach. For the Zoom link and password and to be added to the weekly e-mail for the series, please RSVP. For additional questions, contact CHEPSseminar@umich.edu. Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Thu, 18 Nov 2021 10:24:55 -0500 2021-11-29T16:30:00-05:00 2021-11-29T17:30:00-05:00 Industrial and Operations Engineering Building Center for Healthcare Engineering & Patient Safety (CHEPS) Lecture / Discussion Vikas Parekh, MD
Genetic Study Design in CVFS (December 1, 2021 2:00pm) https://events.umich.edu/event/85338 85338-21626251@events.umich.edu Event Begins: Wednesday, December 1, 2021 2:00pm
Location: Off Campus Location
Organized By: Institute for Social Research

This webinar series on the Chitwan Valley Family Study (CVFS) is about global and comparative population research. Sessions include measuring mental health, Covid-19, linking data, genetics, & migrant data.

Webinar 6: Genetic Study Design in CVFS
Wednesday, December 1, 2021
2-3pm EDT
Presenter: Colter Mitchell

This webinar will provide an overview of the design of the genetic data in CVFS, planned research activities, and potential uses. There will be a Q&A session after the presentation.

The webinar will be hosted using Zoom. Registration is required to attend the webinar. Support provided by NICHD (R25 HD101358).

Registration is required for this event: https://umich.zoom.us/meeting/register/tJctdOChrj4rGN3gN0TKhn3r6F1bAMYUyA3A

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Presentation Tue, 17 Aug 2021 14:33:56 -0400 2021-12-01T14:00:00-05:00 2021-12-01T15:00:00-05:00 Off Campus Location Institute for Social Research Presentation Nepal mountains
Department of Computational Medicine & Bioinformatics Weekly Seminar (December 1, 2021 4:00pm) https://events.umich.edu/event/88514 88514-21654664@events.umich.edu Event Begins: Wednesday, December 1, 2021 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract:

Epigenetic control of gene expression is highly cell-type- and context-specific. Yet, despite its complexity, gene regulatory logic can be broken down into modular components consisting of a transcription factor (TF) activating or repressing the expression of a target gene through its binding to a cis-regulatory region. Recent advances in joint profiling of transcription and chromatin accessibility with single-cell resolution offer unprecedented opportunities to interrogate such regulatory logic. Here, we propose a nonparametric approach, TRIPOD, to detect and characterize three-way relationships between a TF, its target gene, and the accessibility of the TF’s binding site, using single-cell RNA and ATAC multiomic data. We apply TRIPOD to interrogate cell-type-specific regulatory logic in peripheral blood mononuclear cells and contrast our results to detections from enhancer databases, cis-eQTL studies, ChIP-seq experiments, and TF knockdown/knockout studies. We then apply TRIPOD to mouse embryonic brain data during neurogenesis and gliogenesis and identified known and novel putative regulatory relationships, validated by ChIP-seq and PLAC-seq. Finally, we demonstrate TRIPOD on SHARE-seq data of differentiating mouse hair follicle cells and identify lineage-specific regulation supported by histone marks for gene activation and super-enhancer annotations.

Hosted by: Joshua Welch, PhD

Speaker will be in-person and the seminar will be live-streamed via Zoom.

Zoom: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Lecture / Discussion Thu, 21 Oct 2021 14:55:35 -0400 2021-12-01T16:00:00-05:00 2021-12-01T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion Yuchao Jiang (Assistant Professor in the Departments of Biostatistics and Genetics at UNC)
DCM&B Tools and Technology Seminar (December 2, 2021 12:00pm) https://events.umich.edu/event/85371 85371-21626324@events.umich.edu Event Begins: Thursday, December 2, 2021 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

A linear approach is the simplest way to model the relationship between an exposure and an outcome. But a linear approach is limited in only capturing the association that is either strictly increasing or strictly decreasing. This might not adequately represent the associations at the extremes of the distribution for an exposure. For example, in Nguyen et al. 2021, we found that modeling a linear association between an exposure, body mass index (BMI) and an outcome, all-cause mortality resulted in a null relationship (i.e. there is no association between BMI and mortality risk.) This is nonsensical as we intuitively understand that participants with the lowest and highest BMI are at increased risk for all-cause mortality. Our intuition was confirmed when we considered non-linear associations between BMI and all-cause mortality. Furthermore, we observed that the prediction performance for the linear model were on par with those of the non-linear models, but this creates challenges in selecting the most appropriate model. Thus, we developed a visualization tool, called the stairway plots, to compare the linear and non-linear shapes of the associations to help select the most appropriate model. In Nguyen et al. 2021, we used the stairway plots to characterize the non-linear associations between physiological indicators and all-cause mortality. These plots enable us to assess the relevance of the clinical thresholds in differentiating patients who are at high vs. low risk for mortality. Now, we are currently using this visualization tool to study the non-linear associations between chemical exposures and cancer-specific mortality to quantify the cancer mortality risk found at human relevant doses. We plan to deploy this tool as an R package to enable the characterization of linear vs non-linear associations between any exposures and any outcomes of interest.

This presentation will be given remotely, with the livestream available for group viewing in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

URL for remote viewing: https://umich-health.zoom.us/j/94886745590?pwd=LzhLU243K2ZhbXNzU1BJRHQ5V25BZz09

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Presentation Wed, 17 Nov 2021 07:53:51 -0500 2021-12-02T12:00:00-05:00 2021-12-02T13:00:00-05:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
"Hybrid Models to Accelerate Discovery and Optimize Design in Neural Engineering" (December 2, 2021 4:00pm) https://events.umich.edu/event/89543 89543-21664063@events.umich.edu Event Begins: Thursday, December 2, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Abstract:
Neural engineers try to fight disease by interfacing directly with the nervous system to correct or circumvent the pathology, but the complexities of neurophysiology make designing these therapies very difficult. The sophisticated interactions of neural control systems with the body and mind has limited our ability to predict the effects of neural interfaces in advance, which forces the field to rely on painstaking animal experiments to test and design the devices. This work presents an alternate way forward using new functionally predictive hybrid models that let us prototype and test neural interfaces in cheap, low-risk settings to get the most out of the cumbersome and expensive animal and human studies that require implanted electrodes. The key innovation is to combine parts of traditionally separate model systems (animal, human, mathematical, or statistical) into hybrid frameworks that use the strengths of each type to make accurate, use-case predictions about the effects of new neural interfaces.
Details:
DATE: Thursday, December 2, 2021
TIME: 4:00-5:00 pm
LOCATION: Cooley G906
ZOOM LINK: https://umich.zoom.us/j/97723483179

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Lecture / Discussion Mon, 29 Nov 2021 09:57:50 -0500 2021-12-02T16:00:00-05:00 2021-12-02T17:00:00-05:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Event
The Woll Family Speaker Series on Health, Spirituality and Religion presents Emman Dabaja, MD, MPH, Sara Journey, Reni Forer and Meridith Pensler (December 3, 2021 12:00pm) https://events.umich.edu/event/89478 89478-21663263@events.umich.edu Event Begins: Friday, December 3, 2021 12:00pm
Location: Off Campus Location
Organized By: The University of Michigan Medical School Program on Health, Spirituality and Religion

This session will be our yearly session dedicated to hearing from our own Michigan Medicine students and trainees on work they've done at the intersection of spirituality, religion, and medicine.

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Workshop / Seminar Tue, 23 Nov 2021 07:39:06 -0500 2021-12-03T12:00:00-05:00 2021-12-03T13:00:00-05:00 Off Campus Location The University of Michigan Medical School Program on Health, Spirituality and Religion Workshop / Seminar Health, Spirituality and Religion
Data Analytics for Public Health Systems (December 6, 2021 4:30pm) https://events.umich.edu/event/89669 89669-21664760@events.umich.edu Event Begins: Monday, December 6, 2021 4:30pm
Location: Industrial and Operations Engineering Building
Organized By: Center for Healthcare Engineering & Patient Safety (CHEPS)

Data collected within the public health system can be used to advance personalized medicine, target interventions, and evaluate guidelines and practices among many others. It can provide opportunities to set up “policy” labs where policies and interventions can be tested without their direct deployment to the public. In this presentation, I will overview data analytics in healthcare within the paradigm of data science, integrating all data processes from data acquisition and processing to data translation, to data modeling and finally decision making. The overarching message is that data science is at the core of informed decisions, interventions, and ultimately at the core of system’s transformations.

Nicoleta Serban is Virginia C. and Joseph C. Mello Professor in the H. Milton Stewart School of Industrial and Systems Engineering at the Georgia Institute of Technology. Her research record is quite diverse, from mathematical statistics to modeling to data analysis to statistical learning, with recent contributions on drawing principled inferences on healthcare delivery and health policy. She has also been involved in broad impact research activities; the most noteworthy is the leadership of the Health Analytics initiative (http://www.healthanalytics.gatech.edu). This is a collaborative effort anchored in partnership with a varied network of clinicians, healthcare providers, and public health entities. To date, she has published more than 60 journal articles, and a collaborative (with Dr. William B. Rouse) book titled Understanding and Managing the Complexity of Healthcare published by MIT Press and single-authored book titled Healthcare System Access: Measurement, Inference and Intervention published by Wiley. She is the editor for physical sciences, engineering, and the environment for the Annals of Applied Statistics Journal. She has reviewed for multiple funding agencies and she has served in multiple workshops and meetings organized by the National Academies.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach. For the Zoom link and password and to be added to the weekly e-mail for the series, please RSVP. For additional questions, contact CHEPSseminar@umich.edu. Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Wed, 01 Dec 2021 11:54:43 -0500 2021-12-06T16:30:00-05:00 2021-12-06T17:30:00-05:00 Industrial and Operations Engineering Building Center for Healthcare Engineering & Patient Safety (CHEPS) Lecture / Discussion Nicoleta Serban, Ph.D.
LHS Collaboratory (December 7, 2021 12:30pm) https://events.umich.edu/event/88230 88230-21651558@events.umich.edu Event Begins: Tuesday, December 7, 2021 12:30pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Julia Adler-Milstein, PhD
Professor of Medicine and Director of the Center for Clinical Informatics and Improvement Research (CLIIR)
University of California San Francisco

Interoperability is considered a key capability of a high-performing healthcare system and has been a top policy priority for more than a decade. Implementing interoperability is, however, a complex undertaking – requiring stakeholder coordination that tackles incentives, governance, technology, standards, and more. In this talk, Dr. Adler-Milstein will describe current approaches to interoperability and where we stand with respect to current levels of national adoption. She will then discuss the implications for Learning Health System efforts at different levels of scale.

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Livestream / Virtual Wed, 13 Oct 2021 13:59:31 -0400 2021-12-07T12:30:00-05:00 2021-12-07T14:00:00-05:00 Off Campus Location Department of Learning Health Sciences Livestream / Virtual Collaboratory logo
BME PhD Defense: Melissa Lemke (December 8, 2021 1:00pm) https://events.umich.edu/event/89542 89542-21664062@events.umich.edu Event Begins: Wednesday, December 8, 2021 1:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Department of Biomedical Engineering Final Oral Examination

Melissa Lemke

A Systems Approach to Elucidate Personalized Mechanistic Complexities of Antibody-Fc Receptor Activation Post-Vaccination

One of the most significant challenges to current human healthcare is the emergence of antigenically variable viruses that evade traditional vaccination approaches. Human immunodeficiency virus (HIV) is one such virus that emerged over 30 years ago and still has no effective vaccine. Like many other antigenically variable viruses, after infection, HIV quickly mutates to evade broadly neutralizing antibodies that bind tightly to key sites to prevent infection. Over 250 clinical trials have been performed to date to develop an effective HIV vaccine, with only one providing moderate protection; the RV144 Thai trial, estimated to be 31% effective but has not been replicated in other populations. Rather than broadly neutralizing antibodies, the trial identified IgG antibodies with the capacity to induce Fc effector functions as a correlate of protection. These functions are triggered by less specific antibodies that bind HIV antigen and Fc receptors on the surface of innate immune cells to form immune complexes to activate protective cellular functions. Understanding how to increase the formation of IgG-FcR complexes may improve vaccine efficacy, but variation in IgG and FcR features across individuals suggests that protective mechanisms need to be understood on a personalized basis. There are multiple subclasses of protective IgGs, each having different concentrations and affinities to FcRs in different individuals. Genetics can also play a role, with FcR polymorphisms changing FcR binding affinity and IgG1 allotypes changing IgG subclass concentrations. Mechanistic ordinary differential equation (ODE) modeling of this system offers the opportunity to account for these factors on a personalized basis and deconvolve which are most influential and determine how to improve protection universally.


We developed an ODE model of IgG-FcγRIIIa immune complex formation to elucidate how personalized variability in IgG subclass concentration and genetic factors may contribute to complex formation after vaccination. We validated the model with RV144 plasma samples and used it to discover new mechanisms that underpin complex formation. This enabled the identification of genetic and post-translational features that influenced complex formation and suggested the best interventions on a personalized basis. For example, although IgG3 was associated with protection in RV144 and has the highest affinity to FcγRIIIas, the model suggested that IgG1 may play a more essential role, though it also may be highly variable; due to high IgG1 concentration variability across individuals. The model identified RV144 vaccinees who were predicted to be sensitive, insensitive, or negatively affected by increases in HIV-specific IgG1, which was validated experimentally with the addition of HIV-specific IgG1 monoclonal antibodies to vaccine samples. The model also gave important insights into how to maximize IgG-FcγRIIIa complex formation in different genetic backgrounds. We found that individuals with certain IgG1 allotypes were predicted to be more responsive to vaccine adjuvant strategies that increase antibody affinity (e.g., glycosylation modifications) compared to other allotypes, which were predicted to be more responsive to vaccine boosting regimens that increase IgG1 antibody concentration. Finally, simulations in mixed-allotype populations suggest that the benefit of boosting IgG1 concentration versus IgG1 affinity may depend upon the frequency of a specific IgG1 allotype (G1m-1,3) in the population. Overall we believe that this approach represents a valuable tool that will help understand the role of personalized immune mechanisms in response to vaccination and address challenges related to under-represented genetic populations in vaccine trials.

Date: Wednesday, December 8, 2021
Time: 1:00 PM
Zoom: https://umich.zoom.us/j/96971889814
Meeting ID: 969 7188 9814 Passcode: 663036
Chair: Dr. Kelly Arnold

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Lecture / Discussion Mon, 29 Nov 2021 09:50:43 -0500 2021-12-08T13:00:00-05:00 2021-12-08T14:00:00-05:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Event
"EPICode, a multiplexed epitope barcoding strategy that enables dynamic cellular phenotypic screens" (December 9, 2021 4:00pm) https://events.umich.edu/event/89887 89887-21666282@events.umich.edu Event Begins: Thursday, December 9, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Pooled genetic libraries have improved screening throughput for mapping genotypes to phenotypes. However, selectable phenotypes are limiting, restricting screening to outcomes with a low spatiotemporal resolution. Here, we integrated live-cell imaging with pooled library-based screening. To enable intracellular multiplexing, we developed a method, called EPICode (Epitope-Phenotype Immunofluorescence barCode), that uses a combination of short epitopes to facilitate optical screening. By using the subcellular localization of the barcode as an additional channel, our method exponentially increases multiplexing capacity. Thus, after using live-cell microscopy to characterize a phenotype of interest, subjected to sequential stimulatory/inhibitory manipulations, the genotype of each cell in the population can be identified. To demonstrate applicability, we developed a live-cell PKA kinase translocation reporter with improved sensitivity and specificity. The use of epitopes as fluorescent barcodes introduces a scalable strategy for high-throughput screening broadly applicable to protein engineering and drug discovery settings where image-based phenotyping is desired.
Details:
DATE: Thursday, December 9, 2021
TIME: 4:00-5:00 pm
ZOOM LINK: https://umich.zoom.us/j/97723483179

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Workshop / Seminar Wed, 08 Dec 2021 11:33:18 -0500 2021-12-09T16:00:00-05:00 2021-12-09T17:00:00-05:00 Off Campus Location Biomedical Engineering Workshop / Seminar BME Event
BME Ph.D. Defense: Thomas A. Davidson (December 10, 2021 8:00am) https://events.umich.edu/event/89701 89701-21665017@events.umich.edu Event Begins: Friday, December 10, 2021 8:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

Nearly 90% of adults in the US will develop dental caries needing treatment with dental restorations within their lifetimes. An increasing number of restorations are done using composite rather than amalgams. Dental composites have some benefits, but the longevity of these restorations is shorter (5 to 7 years) than amalgams (10+ years). The leading cause of dental restoration failure is development of secondary caries. Secondary caries is decay at or near the margins of dental restorations that occurs when bacteria or acid infiltrate the interface and cause demineralization. A reduction in infiltration would prevent the development of secondary caries. The focus of this dissertation is the development of a method for improving the integrity of the interface using peptide engineering. It was hypothesized that a mineral binding peptide identified via phage display for affinity to apatite could be modified to A) chemically incorporate with dental composites during polymerization and increase bond strength and B) act as an anchor for a mineralization promoting peptide to increase remineralization at the interface.


First, this thesis describes the characterization of VTKHLNQISQSY (VTK) peptide and phosphorylated variants (pVTK) for their affinity to dentin and enamel and the increase in adhesion strength at the nano-scale. pVTK showed strong affinity to dentin and enamel, and both VTK and pVTK exhibited strong adhesion to dentin and enamel at the nanoscale under dry and wet conditions. Binding at the nanomolecular level translated to modest shear bond strength (SBS) increases at the interface when pVTK (7.4%) was modified with a cysteine that incorporated with the methacrylate-based bonding agent and composite during polymerization. Using a competitive risk model incorporating failure mode and SBS, a small increase in bond strength (VTK: 3%; pVTK: 10%) was observed.


The second modification to VTK was the addition of a remineralization domain using 8DSS, a known remineralization peptide consisting of 8 repeats of Asp-Ser-Ser (DSS). The dual-functioning peptide (VTK-8DSS) was applied to in vitro cross sections of dentin and enamel and an in situ model of class V dental restorations. Mineral deposition and quality were assessed over 7 days in remineralization solution. VTK-8DSS increased the mineral quality (recovering 75% of young’s modulus and hardness compared to 50% of 8DSS control) determined using nanoindentation over the 7 day time course of the study.


These modifications were also analyzed under challenging conditions for their protective effect to the interface. VTK and pVTK doped composites were exposed to thermal cycling and had a 43% and 49% reduction in microleakage as measured by silver nitrate penetration using micro CT. Cross sections and dental restorations were used to assess the function of VTK-8DSS in artificial saliva containing proteins that competitively bind to dentin and enamel and an acidic cycling model where samples were exposed to acid every day in addition to remineralization solution. VTK-8DSS in both artificial saliva and acidic cycling models showed a slight increase in mineral deposition (95% and 95% recovery) compared to 8DSS (80% and 50% respectively) and a large increase mineral quality (70% vs 10% and 60% vs 30%).


Taken together, the data in this dissertation demonstrates the ability to engineer interfacial surfaces using peptides derived for their affinity to specific tissues. This system could be applied more broadly to improve the interactions or integration of any number of biomaterials that directly interface with native tissue.


Date: Friday, December 10, 2021
Time: 8:00 AM EST
Zoom: https://umich.zoom.us/j/97816028147 (Zoom link requires prior registration)
Chair: Dr. David Kohn

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Lecture / Discussion Thu, 02 Dec 2021 09:36:52 -0500 2021-12-10T08:00:00-05:00 2021-12-10T09:00:00-05:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Event
Complex Systems Presents the Annual Nobel Symposium (December 10, 2021 10:00am) https://events.umich.edu/event/89502 89502-21664099@events.umich.edu Event Begins: Friday, December 10, 2021 10:00am
Location: Off Campus Location
Organized By: The Center for the Study of Complex Systems

CLICK TO SEE RECORDINGS OF THE TALKS: https://lsa.umich.edu/cscs/news-events/all-events/event-recordings.html

Registration not required. Free and open to the public. This will be a virtual symposium. This popular annual event features UM faculty experts in each of the six prize fields. Each will present for approximately 25 minutes and then will take some questions. There is a scheduled lunch break. Come to one talk, come to them all.

SCHEDULE
10:00 AM Opening remarks, Marisa Eisenberg, Interim Director of Complex Systems
10:05 AM Physics, Mark Newman, LSA Complex Systems & Physics AND Richard Rood, Engineering & SEAS
10:55 AM Chemistry, Corey Stephenson, LSA Chemistry
11:30 AM Physiology or Medicine, Shawn Xu, Michigan Medicine Molecular and Integrative Physiology & Life Sciences Institute AND Rui Xiao, University of Florida, Center for Smell and Taste (special guest and Michigan Alumni)

12:05 PM Lunch break

1:00 PM Economics: Tanya Rosenblat, School of Information and LSA Economics
1:35 PM Literature: Gaurav Desai, LSA English Language and Literature
*This talk is co-sponsored by the African Studies Center (ii.umich.edu/asc)*
2:10 PM Peace: Lynette Clemetson, Wallace House (Knight-Wallace Fellowships) AND Ron Suny, LSA History & Political Science
3:00 PM Closing remarks

For information on prize winners, please click the Nobel Prize winners link below. Other information on the Nobel Prizes can be found on the website nobelprize.org

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Conference / Symposium Wed, 22 Dec 2021 21:25:28 -0500 2021-12-10T10:00:00-05:00 2021-12-10T15:00:00-05:00 Off Campus Location The Center for the Study of Complex Systems Conference / Symposium Symposium Poster
BME PH.D. Defense: Christopher D. Davidson (December 10, 2021 1:00pm) https://events.umich.edu/event/89668 89668-21664759@events.umich.edu Event Begins: Friday, December 10, 2021 1:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

The ability of cells to communicate and coordinate their activity is crucial to the development and homeostatic function of all tissues. In addition to the well-established means of biochemically mediated signaling, a more recent body of evidence has indicated that cells can also communicate via cell-generated forces transmitted to neighboring cells through the extracellular matrix (ECM). One setting in which a deeper understanding of mechanical intercellular communication (MIC) would be extremely valuable is in vasculogenesis, or the de novo formation of a microvascular network. This dynamic process involves the assembly and organization of individual endothelial progenitor cells into an interconnected network of capillaries, thus requiring cellular communication and coordination over large spatial scales. If fully understood and harnessed, vasculogenic assembly presents a promising approach to vascularizing engineered tissue constructs for regenerative medicine applications. We hypothesize physical properties of the ECM are critical to MIC as the matrix context defines not only the generation of cell forces but also force transmission through the matrix to nearby cells. Thus, the focus of this dissertation is to study cell force propagation and MIC between endothelial cells (ECs) in controllable synthetic ECMs towards the informed design of biomaterials that drive rapid self-assembly of functional microvascular networks.



First, this thesis explores how physical attributes of the ECM regulate the assembly of ECs into interconnected multicellular networks. To mimic the fibrous microenvironments where neovascularization typically occurs in the body, we developed a novel model of the EC network formation assay utilizing 2.5D matrices of electrospun synthetic dextran methacrylate (DexMA) polymeric fibers. Our results revealed that active cell-mediated matrix deformations and fiber recruitment through actomyosin force generation occurs concurrently with the formation and stabilization of multicellular EC networks.



Next, this thesis describes the development and characterization of a new material system composed of electrospun dextran vinyl sulfone (DexVS) polymeric fibers that possess longer-term mechanical stability in culture as compared to DexMA matrices. These matrices were utilized for two major objectives: 1) investigating the role of matrix mechanics on the activation of fibroblasts into myofibroblasts, a key component of wound healing and the fibrotic progression, and 2) exploring the impact of nonlinear matrix mechanical properties on vasculogenic assembly by imbuing fibers with crimped microstructure.



Lastly, this thesis describes the mechanism of MIC between individual ECs during vasculogenic assembly. By combining electrospun DexMA fiber matrices with a microfabrication-based cell-patterning method, we investigated EC force-mediated matrix displacements and MIC as a function of matrix stiffness and identified the critical cellular machinery required for ECs to sense and respond to mechanical signals emanating from neighboring cells. We then sought to harness these observations in more translatable 3D hydrogel constructs by using a composite approach where fibrin hydrogels were reinforced with electrospun DexVS fiber segments. While traditional approaches to prevascularize 3D hydrogels require long-term co-cultures of ECs and support stromal cells, our work demonstrated that mechanical cues from synthetic fibers enable ECs alone to rapidly self-assemble into networks of lumenized capillary-like structures.



Overall, the work presented in this dissertation integrates biomaterials, tissue engineering, and microfabrication approaches to investigate the mechanobiology of how cell forces regulate intercellular communication during vasculogenic assembly. The results presented here are critical to the design of biomaterials that promote robust capillary network assembly for applications in tissue engineering and regenerative medicine.



Date: Friday, December 10, 2021

Time: 1:00 PM EST

Zoom: https://umich.zoom.us/meeting/register/tJAoceuhqD0rHdwL8duV6QwOcYjLXl14kysD (Zoom link requires prior registration)

Chair: Dr. Brendon Baker

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Lecture / Discussion Wed, 01 Dec 2021 11:44:48 -0500 2021-12-10T13:00:00-05:00 2021-12-10T14:00:00-05:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Event
"Projections: A Story of Human Emotions" - A Virtual Conversation with Author Dr. Karl Deisseroth (January 6, 2022 3:00pm) https://events.umich.edu/event/90459 90459-21671097@events.umich.edu Event Begins: Thursday, January 6, 2022 3:00pm
Location: Off Campus Location
Organized By: Michigan Neuroscience Institute

Dr. Karl Deisseroth is the D.H. Chen Professor of Bioengineering, Psychiatry & Behavioral Sciences at Stanford University. In his recently published book, "Projections: A Story of Human Emotions," Deisseroth uses cutting-edge research and medical case studies to examine some of our most fundamental human traits and shed light on the origins of our emotions. The event will include an initial conversation between Drs. Deisseroth and Akil followed by questions from participants.

The event is free, but participants must register for the event to receive the zoom link.

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Lecture / Discussion Wed, 05 Jan 2022 11:24:10 -0500 2022-01-06T15:00:00-05:00 2022-01-06T16:00:00-05:00 Off Campus Location Michigan Neuroscience Institute Lecture / Discussion Dr. Karl Deisseroth
CANCELED: Coming home: The LSO Returns (January 9, 2022 4:00pm) https://events.umich.edu/event/89967 89967-21667077@events.umich.edu Event Begins: Sunday, January 9, 2022 4:00pm
Location: Hill Auditorium
Organized By: Life Sciences Orchestra

THIS EVENT HAS BEEN CANCELED OUT OF AN ABUNDANCE OF CAUTION. ANY FURTHER PLANS WILL BE POSTED ON THE LSO WEBSITE.

After a two-year hiatus from performing on the stage of U-M's legendary Hill Auditorium, the U-M Life Sciences Orchestra will once again fill the hall with music on Sunday, Jan. 9 beginning at 4 p.m., with a free concert that will follow COVID safety protocols for performers and audience members alike.

No tickets are needed but good-fitting masks and proof of vaccination or a recent negative PCR test will be required and no children under 3 will be admitted. Full details of our COVID-19 safety protocols are below.

The concert, conducted by music director Yeo Ryeong Ahn assisted by Leonard Bopp, will feature three melodic and uplifting works that will appeal to all:
Aaron Copland - Outdoor Overture
Florence Price - Piano Concerto in One Movement with special guest soloist Xiaoya Liu
Antonin Dvorak - Symphony No. 9 in E minor, "From the New World", Op. 95, B. 178

Any updates to the concert schedule due to weather or U-M/local pandemic protocols will be posted on this website and on the LSO Facebook page.

COVID-19 Protocols:
For the safety of our audience and performers, we will follow strict safety protocols. We will update these as necessary depending on U-M and local/state public health guidance and any updates will be posted on this Facebook event and our website.
1. All attendees and performers must complete the Responsiblue screening and show their results on a smartphone or printout on arrival. Those who are part of the U-M community should use the logged-in version, which also displays vaccination status; those who are not part of the U-M community should use this link: https://bit.ly/LSOguest. This MUST be completed for each member of the party including children.

2. All attendees and performers must wear a good-fitting mask over their nose and mouth at all times except when drinking water. (Brass and woodwind players are permitted to remove it when actively playing, as all performers have been vaccinated.)

3. No children under age 3 will be allowed.

4. All children and adults must show proof of vaccination (card, photo of card, approved app such as MyChart or Clear, or logged-in Responsiblue screen) OR show the results of a PCR test taken no longer that 72 hours before the concert time.

5. No refreshments will be sold or allowed, though water may be brought in.

6. Families with 3- and 4-year-old children (too young to be vaccinated), and any party that includes children/adults who are not yet fully vaccinated, are asked to sit apart from others, preferably in the mezzanine (lower balcony).

7. We encourage everyone eligible for a booster vaccination (which is anyone over age 16) to seek a booster dose before attending.

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Performance Mon, 03 Jan 2022 12:35:04 -0500 2022-01-09T16:00:00-05:00 2022-01-09T17:45:00-05:00 Hill Auditorium Life Sciences Orchestra Performance LSO Concert poster featuring composer Florence Price
It's All About Life and Dignity (January 10, 2022 12:00pm) https://events.umich.edu/event/89288 89288-21661819@events.umich.edu Event Begins: Monday, January 10, 2022 12:00pm
Location: Off Campus Location
Organized By: The University of Michigan Medical School Program on Health, Spirituality and Religion

Sister Helen Prejean is known around the world for her tireless work against the death penalty. She has been instrumental in sparking national dialogue on capital punishment and in shaping the Catholic Church’s vigorous opposition to all executions.

Born in Baton Rouge, Louisiana, in the 1930s, Sister Helen grew up in the segregated Jim Crow South. At the age of 18 she joined the Sisters of St. Joseph. She worked as a high school teacher and religious education director in New Orleans before moving into the St. Thomas Housing Project in the early ’80s.

In 1982, Sister Helen began corresponding with Patrick Sonnier, who had been sentenced to death for the murder of two teenagers. Two years later, when Patrick Sonnier was put to death in the electric chair, Sister Helen was there to witness his execution. In the following months, she became spiritual advisor to another death row inmate, Robert Lee Willie, who was to meet the same fate as Sonnier.

After witnessing these executions, Sister Helen realized that this lethal ritual would remain unchallenged unless its secrecy was stripped away, and so she sat down and wrote a book, Dead Man Walking: An Eyewitness Account of the Death Penalty in the United States. That book ignited a national debate on capital punishment and spawned an Academy Award winning movie, a play, and an opera.

Sister Helen’s second book, The Death of Innocents: An Eyewitness Account of Wrongful Executions, was published in 2004; and her third book, River of Fire: My Spiritual Journey, in August, 2019. She is currently collaborating on a graphic retelling of Dead Man Walking, to be published by Random House.

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Workshop / Seminar Tue, 16 Nov 2021 07:03:03 -0500 2022-01-10T12:00:00-05:00 2022-01-10T13:00:00-05:00 Off Campus Location The University of Michigan Medical School Program on Health, Spirituality and Religion Workshop / Seminar Sr. Helen Prejean
BME PhD Defense: Olga M. Wroblewski (January 12, 2022 10:00am) https://events.umich.edu/event/90462 90462-21671089@events.umich.edu Event Begins: Wednesday, January 12, 2022 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

Volumetric muscle loss (VML) is a common pathological condition caused by traumatic loss of skeletal muscle that exceeds the muscle’s regenerative capabilities and results in functional impairment. Current surgical standards-of-care frequently fail to fully recover contractile function. To address these limitations, our laboratory has developed scaffold-free tissue engineered skeletal muscle units (SMUs) for the treatment of VML. Isolated skeletal muscle stem cells (satellite cells) and fibroblasts are cultured into a confluent cell monolayer before being rolled into a cylindrical 3D construct. Ideally, these SMUs could be engineered from small autogenic muscle biopsies, alleviating the limitations of donor site morbidity and immune rejection seen in current VML treatments. These SMUs are biocompatible, incorporate into surrounding muscle tissue upon implantation, and have shown efficacy to partially repair a 30% VML in rat and sheep models. There are two key challenges that must be resolved to successfully translate our technology to a human cell-sourced model. To date, it has been difficult to grow human cell-sourced SMUs with any noteworthy contractile function. Secondly, many satellite cells are required for SMU fabrication. Any methodology that can optimize the number of cells obtained in a human skeletal muscle biopsy and enhance the functional properties of the resultant muscle tissue will advance SMUs towards clinical use.

Human epidermal growth factor (hEGF), a mitogen, has shown promise enhancing myobundle formation and contractile function in vitro. Prior to this thesis work, the impact of hEGF treatment during the proliferation and differentiation phases of SMU fabrication had yet to be evaluated. We investigated the effects of hEGF on SMU fabrication, structure, and biomechanical function. Our results indicated that hEGF was critical for the development of contractile function in human cell-sourced SMUs.

Due to the small amount of satellite cells present in skeletal muscle, we also sought to optimize our methodologies so that fewer satellite cells are needed to be isolated to fabricate SMUs. Currently, we have been successful at fabricating functional SMUs using lower cell-seeding densities compared to rat and sheep models. By altering the timing of our fabrication protocol and allowing cell cultures to reach >90% confluency in media that promotes proliferation, we found that we could lower starting cell-seeding density by 90% compared to ovine models with no detrimental impact to monolayer development or SMU function.

To further expand the capabilities of satellite cells from a single autogenic skeletal muscle biopsy, we evaluated the impact of in vitro cell proliferation (increasing cell number by cell passaging) on human primary skeletal muscle cells within an engineered skeletal muscle tissue environment. While cell passaging decreased the percentage of myogenic cells in the total cell population, results indicated that human primary skeletal muscle cells can be passaged without negatively impacting the contractile function of a skeletal muscle construct compared to one created with unpassaged cells. A single passage can increase the total cell yield from a human skeletal muscle biopsy fiftyfold compared to cells harvested without a passage.

Overall, this work significantly contributed to the field of skeletal muscle tissue engineering by advancing fabrication methodologies to develop SMUs of appropriate structure and function for human application. We addressed two key limitations in human cell-sourced skeletal muscle tissue engineering by optimizing cell culture conditions to increase the cell yield from a single skeletal muscle biopsy while promoting SMU biomechanical function.

Date: Wednesday, January 12, 2022
Time: 10:00 AM EST
Zoom: https://umich.zoom.us/meeting/register/tJUocu2gqjMpGdelbor8Vj43NvRde859Q-EE
(Zoom link requires prior registration)
Chair: Dr. Lisa Larkin

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Lecture / Discussion Wed, 05 Jan 2022 08:59:08 -0500 2022-01-12T10:00:00-05:00 2022-01-12T11:00:00-05:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Event
Child Health Data in the CVFS (January 12, 2022 2:00pm) https://events.umich.edu/event/85340 85340-21626253@events.umich.edu Event Begins: Wednesday, January 12, 2022 2:00pm
Location: Off Campus Location
Organized By: Institute for Social Research

This webinar series on the Chitwan Valley Family Study (CVFS) is about global and comparative population research. Sessions include measuring mental health, Covid-19, linking data, genetics, & migrant data.

Webinar 8: Child Health Data in the CVFS
Wednesday, January 12, 2022
2-3pm EDT
Presenter: Emily Treleaven

This webinar will give an overview of previous data collections of child health measures, child health outcomes among the CVFS sample, and compare child health indicators in the CVFS sample to the broader population of Nepal using Demographic and Health Survey data. There will be a Q&A session after the presentation.

The webinar will be hosted using Zoom. Registration is required to attend the webinar. Support provided by NICHD (R25 HD101358).

Registration is required for this event: https://umich.zoom.us/meeting/register/tJMqd-uprzIvHtapbdIOc1dQtiZmplrODd9k

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Presentation Tue, 17 Aug 2021 14:42:30 -0400 2022-01-12T14:00:00-05:00 2022-01-12T15:00:00-05:00 Off Campus Location Institute for Social Research Presentation Nepal mountains
A Truly Subject-Specific, Shared Model of the Human Tricuspid Valve (January 13, 2022 3:30pm) https://events.umich.edu/event/90763 90763-21673517@events.umich.edu Event Begins: Thursday, January 13, 2022 3:30pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Abstract: Computer simulations have become critical elements of the medical device design and regulatory approval process. Naturally, the predictability and therefore value of such simulations depends highly on their accuracy. Especially for the design of heart valve replacements and repair technologies computer simulations have become a critical tool. While much progress has been made in modeling the aortic valve and the mitral valve, much less effort has been spent on modeling the tricuspid valve. The reasons are multi-fold, but include the general neglect of the valve as well as the high complexity of the valve in comparison to the three other valves. In our most recent work, we are beginning to fulfill this gap. Specifically, our objective is to develop, validate, and then publicly provide a truly subject-specific, shared model of the human tricuspid valve. To this end, we combine multi imaging-modality based measurements in beating human hearts that have been prepared in an organ preservation system, with in-vitro measurements of heart valve geometric, structural, and mechanical properties. Once built, we conduct finite element simulations with this valve and validate dynamic simulations throughout the cardiac cycle against in-situ measurements. Finally, we show case our model by first mimicking a diseased valve, which we then repair using a surgical and an interventional approach.

Bio: Dr. Rausch is an assistant professor at the University of Texas at Austin where he directs the soft tissue biomechanics laboratory. His laboratory's objective is to use complimentary imaging modalities, mechanical testing, and numerical methods to understand and predict soft tissue disease. The specific problems he studies include pressure ulcers, right heart heart failure, tricuspid valve regurgitation, and thrombotic disease. Check out his work on www.manuelrausch.com and follow him on Twitter under @ManuelKRausch1.

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Workshop / Seminar Mon, 10 Jan 2022 16:14:23 -0500 2022-01-13T15:30:00-05:00 2022-01-13T16:30:00-05:00 Off Campus Location Biomedical Engineering Workshop / Seminar BME Seminar
32nd Annual MLK Health Sciences Lecture (January 17, 2022 12:00pm) https://events.umich.edu/event/90537 90537-21671504@events.umich.edu Event Begins: Monday, January 17, 2022 12:00pm
Location: Off Campus Location
Organized By: U-M College of Pharmacy

The College of Pharmacy and the MLK Health Sciences Committee invite you to attend the 2022 MLK Health Sciences Lecture, entitled: “This is America: Confronting Health Inequities...Writing Prescriptions for Change.”

The lecture will take place on January 17, 2022, from 12:00 pm – 1:30 pm via Zoom. Registration is required.

The keynote lecture will be delivered by Dr. Lakesha Butler, PharmD. Dr. Butler is a Clinical Professor of Pharmacy Practice and the Director of Diversity, Equity and Inclusion at Southern Illinois University Edwardsville (SIUE) School of Pharmacy. She is also the CEO and Founder of Dr. Lakesha Butler, LLC, a consulting agency whose mission is to disrupt and dismantle inequities and injustices in healthcare and higher education. Dr. Butler is the immediate past president of the National Pharmaceutical Association (NPhA) and the American Association of Colleges of Pharmacy (AACP) Council of Sections chair-elect.

Dr. Butler’s leadership and impact spans broadly at the school and institutional level, nationally and in her community serving in various leadership roles. She is a national speaker on the topics of antiracism, diversity, equity and inclusion. She is also the co-author of numerous peer-reviewed articles including “Systemic racism: pharmacists’ role and responsibility,” “Holding pharmacy educators accountable in the wake of the anti-racism movement: a call to action,” and “Developing a framework to address health equity and racism within pharmacy education: RX-HEART.”

Dr. Butler received her doctorate of pharmacy from Mercer University in Atlanta, GA and completed a pharmacy practice residency at the University of Illinois at Chicago. She has received extensive leadership and DEI training and is a Certified Diversity Facilitrainer (CDFT).

The MLK Health Sciences Lecture is sponsored by the University of Michigan School of Dentistry; School of Kinesiology; Michigan Medicine / Medical School / Office for Health Equity & Inclusion; Michigan Institute for Clinical & Health Research; School of Nursing; College of Pharmacy; School of Public Health; and the School of Social Work.

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Livestream / Virtual Thu, 06 Jan 2022 10:52:26 -0500 2022-01-17T12:00:00-05:00 2022-01-17T13:30:00-05:00 Off Campus Location U-M College of Pharmacy Livestream / Virtual Dr. Lakesha Butler
Advancing Climate Justice & Environmental Health: people-centered approaches to transformational research (January 18, 2022 12:00pm) https://events.umich.edu/event/90764 90764-21673518@events.umich.edu Event Begins: Tuesday, January 18, 2022 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

REGISTRATION REQUIRED
https://umich.zoom.us/webinar/register/WN_qa4rv9J3SZehApoPqRPIVw
A life-long learner and advocate, Dr. Jalonne L. White-Newsome founded Empowering a Green Environment and Economy, LLC, a strategic consulting firm, with the mission of transforming communities through the development of people-centered solutions. She serves a diverse set of clients with forward-thinking and intersectional approaches to tackle issues such as climate change, public health, environmental injustice, and advancing racial equity.

Dr. White-Newsome ha has multi-sector experience having worked in environmental philanthropy, state government, non-profit, grassroots, academia and private industry. Most notably, she created and implemented the transformational Climate Resilient and Equitable Water Systems (CREWS) Initiative at the Kresge Foundation as a Senior Program Officer; she was the first Director of WE ACT for Environmental Justice’s federal policy office in Washington, DC; and, her doctoral research illuminated the impact of climate change & extreme heat on the low-income, elderly in Detroit, and is still referenced to drive public health interventions.

A native of Detroit, Jalonne earned a Ph.D. in environmental health sciences from the University of Michigan School of Public Health, a master’s degree in environmental engineering from Southern Methodist University, a bachelor’s degree in chemical engineering from Northwestern University, and her certificate in Diversity and Inclusion from Cornell University.

Jalonne serves on multiple national and local academic, non-profit and for-profit Boards. She is a Lecturer at The George Washington University Milken Institute School of Public Health, a lifetime member of Delta Sigma Theta Sorority, Inc., and the proud mom of Arielle and Jeannelyn.

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Lecture / Discussion Mon, 10 Jan 2022 16:24:08 -0500 2022-01-18T12:00:00-05:00 2022-01-18T12:50:00-05:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Jan 18 Advancing Climate Justice & Environmental Health
LHS Collaboratory (January 18, 2022 12:00pm) https://events.umich.edu/event/89940 89940-21666535@events.umich.edu Event Begins: Tuesday, January 18, 2022 12:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

This presentation will explore how Big Data Science and Informatics research can overcome deficiencies within the electronic health record and optimize real world data collection. We will discuss examples of how standardized nomenclature integrated into clinical workflow can enable statistical AI methods to advance clinical decision support and improve outcome models. Our successes in radiation oncology come from single multi-institutional, multi-national and multi-professional society collaboration.

Presenters:
Charles Mayo, PhD
Professor
Director of Radiation Oncology Informatics and Analytics
Department of Radiation Oncology
University of Michigan Medical School

Michelle Mierzwa, MD
Associate Professor
Associate Chair of Clinical Research
Co-Chair of Head and Neck Clinical Trials
Department of Radiation Oncology
University of Michigan Medical School

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Lecture / Discussion Tue, 11 Jan 2022 15:56:37 -0500 2022-01-18T12:00:00-05:00 2022-01-18T13:30:00-05:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion Collaboratory logo
Thriving with Everyday Cognitive Behavioral Therapy (January 19, 2022 6:00pm) https://events.umich.edu/event/87832 87832-21647057@events.umich.edu Event Begins: Wednesday, January 19, 2022 6:00pm
Location: Off Campus Location
Organized By: Michigan Medicine Wellness Office

Stress and anxiety can inhibit our ability to thrive physically, mentally, and spiritually. Learn what cognitive behavioral therapy is, and how to incorporate it into your daily life so you can THRIVE every day.

Please register to receive zoom link: https://sessions.studentlife.umich.edu/track/event/session/45696

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Well-being Mon, 04 Oct 2021 11:41:55 -0400 2022-01-19T18:00:00-05:00 2022-01-19T19:00:00-05:00 Off Campus Location Michigan Medicine Wellness Office Well-being Wellness Office Logo
DCM&B Tools and Technology Seminar (January 20, 2022 12:00pm) https://events.umich.edu/event/89769 89769-21665747@events.umich.edu Event Begins: Thursday, January 20, 2022 12:00pm
Location: Off Campus Location
Organized By: DCMB Tools and Technology Seminar

This presentation will be given remotely, with the livestream available via Zoom.

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Presentation Mon, 17 Jan 2022 10:08:14 -0500 2022-01-20T12:00:00-05:00 2022-01-20T13:00:00-05:00 Off Campus Location DCMB Tools and Technology Seminar Presentation
Organizational Science and Health Care (January 21, 2022 1:30pm) https://events.umich.edu/event/90175 90175-21668509@events.umich.edu Event Begins: Friday, January 21, 2022 1:30pm
Location: Ross School of Business
Organized By: Interdisciplinary Committee on Organizational Studies - ICOS

Research on topics of organizational science in health care settings for a variety of reasons has proliferated in recent years across both organization- and health-focused disciplines. Yet, questions abound about what we as organizational scholars know, what we have learned, and whether the research we are conducting is relevant. The first goal of this session is to take stock of this important domain by drawing together findings from two recent works: a critical history and analysis of the patient safety movement and an analysis of almost 700 articles published over the past decade in leading organizational science (OS) and health care (HC) journals. A second goal is to provide insight into promising avenues that could ultimately advance organizational science and health care with future research that is both rigorous and relevant.

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Lecture / Discussion Tue, 21 Dec 2021 22:41:02 -0500 2022-01-21T13:30:00-05:00 2022-01-21T15:00:00-05:00 Ross School of Business Interdisciplinary Committee on Organizational Studies - ICOS Lecture / Discussion Ross School of Business
Organizational Science and Health Care (January 21, 2022 1:30pm) https://events.umich.edu/event/90175 90175-21668766@events.umich.edu Event Begins: Friday, January 21, 2022 1:30pm
Location: Off Campus Location
Organized By: Interdisciplinary Committee on Organizational Studies - ICOS

Research on topics of organizational science in health care settings for a variety of reasons has proliferated in recent years across both organization- and health-focused disciplines. Yet, questions abound about what we as organizational scholars know, what we have learned, and whether the research we are conducting is relevant. The first goal of this session is to take stock of this important domain by drawing together findings from two recent works: a critical history and analysis of the patient safety movement and an analysis of almost 700 articles published over the past decade in leading organizational science (OS) and health care (HC) journals. A second goal is to provide insight into promising avenues that could ultimately advance organizational science and health care with future research that is both rigorous and relevant.

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Lecture / Discussion Tue, 21 Dec 2021 22:41:02 -0500 2022-01-21T13:30:00-05:00 2022-01-21T15:00:00-05:00 Off Campus Location Interdisciplinary Committee on Organizational Studies - ICOS Lecture / Discussion
Programmable Biomaterials/Regenerative Medicine Grand Challenge (January 24, 2022 1:00pm) https://events.umich.edu/event/88715 88715-21677237@events.umich.edu Event Begins: Monday, January 24, 2022 1:00pm
Location: Off Campus Location
Organized By: Regenerative Medicine Biosciences Initiative

Programmable Biomaterials/Regenerative Medicine Grand Challenge #1

Theme: How to regenerate tissues/organs to optimally integrate with the host

Goal: Bring together clinicians, scientists, and engineers to explore new ideas and catalyze new collaborations to address key barriers to the translation of regenerative medicine technologies

Format: Short talks identifying clinical problems and emerging technologies, followed by breakout sessions to identify opportunities

Breakouts: Based on problems identified, what are transformative things UM can do to solve? We’re looking for big ideas that involve new, heterogeneous groups. Themes/challenges that emerge from breakouts will define an RFA

Outcome: Funding for collaborative proposals that emerge from the grand challenge session w/ criteria that proposals are novel and integrative, satisfying one or more of the following elements:
•High risk, cross-cutting, transformative
•Leverage strengths at UM in new ways
•Pull together new combinations of people
•Tackle new problems or existing problems in new ways
•Topics that will have greatest impact and potential for extramural funding
•We anticipate awarding 3 grants at ~100K each
Please join us for our 2-day VIRTUAL event January 24 and January 25.

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Workshop / Seminar Tue, 18 Jan 2022 19:32:41 -0500 2022-01-24T13:00:00-05:00 2022-01-24T18:30:00-05:00 Off Campus Location Regenerative Medicine Biosciences Initiative Workshop / Seminar Purple Pipette
Programmable Materials/Regenerative Medicine Grand Challenge-Breakout Sessions (January 25, 2022 9:00am) https://events.umich.edu/event/88716 88716-21656961@events.umich.edu Event Begins: Tuesday, January 25, 2022 9:00am
Location: Off Campus Location
Organized By: Regenerative Medicine Biosciences Initiative

Programmable Biomaterials/Regenerative Medicine Grand Challenge Breakout Rooms

Theme: How to regenerate tissues/organs to optimally integrate with the host

Goal: Bring together clinicians, scientists, and engineers to explore new ideas and catalyze new collaborations to address key barriers to the translation of regenerative medicine technologies

Format: Short talks identifying clinical problems and emerging technologies, followed by breakout sessions to identify opportunities

Breakouts: Based on problems identified, what are transformative things UM can do to solve? We’re looking for big ideas that involve new, heterogeneous groups. Themes/challenges that emerge from breakouts will define an RFA

Outcome: Funding for collaborative proposals that emerge from the grand challenge session w/ criteria that proposals are novel and integrative, satisfying one or more of the following elements:
•High risk, cross-cutting, transformative
•Leverage strengths at UM in new ways
•Pull together new combinations of people
•Tackle new problems or existing problems in new ways
•Topics that will have greatest impact and potential for extramural funding
•We anticipate awarding 3 grants at ~100K each
Please join us for our 2-day VIRTUAL event January 24 and January 25.

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Workshop / Seminar Tue, 18 Jan 2022 19:31:38 -0500 2022-01-25T09:00:00-05:00 2022-01-25T12:00:00-05:00 Off Campus Location Regenerative Medicine Biosciences Initiative Workshop / Seminar Regenerative Medicine Grand Challenge
CVFS COVID-19 2021 Pilot (January 26, 2022 2:00pm) https://events.umich.edu/event/85341 85341-21626254@events.umich.edu Event Begins: Wednesday, January 26, 2022 2:00pm
Location: Off Campus Location
Organized By: Institute for Social Research

This webinar series on the Chitwan Valley Family Study (CVFS) is about global and comparative population research. Sessions include measuring mental health, Covid-19, linking data, genetics, & migrant data.

Webinar 9: CVFS COVID-19 2021 Pilot
Wednesday, January 26, 2022
2-3pm EDT
Presenter: Sabrina Hermosilla

This webinar will review the methods and primary findings from the COVID-19 CVFS Pilot Study implemented in the first quarter of 2021. This study explored the physical, social, and economic disruptions caused by COVID-19 prevention measures within households of the CVFS. There will be a Q&A session after the presentation.

The webinar will be hosted using Zoom. Registration is required to attend the webinar. Support provided by NICHD (R25 HD101358).

Registration is required for this event: https://umich.zoom.us/meeting/register/tJYqcuCgpz8jGtNqH0O03W4w1QbQmBQAS1ph

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Presentation Tue, 17 Aug 2021 14:47:13 -0400 2022-01-26T14:00:00-05:00 2022-01-26T15:00:00-05:00 Off Campus Location Institute for Social Research Presentation Nepal mountains
DCM&B Tools and Technology Seminar (January 27, 2022 12:00pm) https://events.umich.edu/event/89771 89771-21665751@events.umich.edu Event Begins: Thursday, January 27, 2022 12:00pm
Location: Off Campus Location
Organized By: DCMB Tools and Technology Seminar

Tool link: https://github.com/statgen/savvy

This presentation will be given remotely, with the livestream available via Zoom.

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Presentation Thu, 20 Jan 2022 15:23:09 -0500 2022-01-27T12:00:00-05:00 2022-01-27T13:00:00-05:00 Off Campus Location DCMB Tools and Technology Seminar Presentation
Elasticity Imaging: From Fibrosis and Tumor Pressure to Mechanotransduction and Visualizing Primary Neuronal Activity (January 27, 2022 3:30pm) https://events.umich.edu/event/91489 91489-21680069@events.umich.edu Event Begins: Thursday, January 27, 2022 3:30pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Abstract:
Only recently have we understood the importance of mechanical forces between cells to generate tissue homeostasis. This translates equally to the organ level with tissue biomechanics an excellent proxy for pathological alterations.

In this lecture we will review the current method of quantifying tissue biomechanics via MRI using mechanical shear waves elicitated at the surface of the patient, new ways to quantify non-invasively tumour pressure via non-linear mechanics, and look into mechanical changes induced by neuronal activities. Finally, we will change our position from being a passive bystander quantifying tissue mechanics to an active player altering cellular fate via shear waves.
Bio:
Professor Ralph Sinkus is a physicist with a background in high energy physics, nuclear physics and MRI. He has dual labs at King’s College London’s School of Biomedical Engineering and Imaging Sciences as well as at INSERM (University Paris Diderot, Sorbonne Paris Cité, Hôpital Bichat/Beaujon, Paris, France). After a PhD in high energy physics (DESY, Deutsches Elektronen Synchrotron, Hamburg, Germany), Professor Sinkus took a position at Philips Medical Systems Research Laboratories (Hamburg, Germany) focusing on magnetic resonance imaging (MRI) and elastography. Moving back to academia, Professor Sinkus worked for the Laboratoire Ondes et Acoustique (ESPCI) in Paris, France as a research director until accepting a chair position at King’s College London. Professor Sinkus is an expert in MRI and MR-elastography, and works with a diverse range of clinicians, biomedical engineers, physists and mathematicians for the translation of these technologies to address clinical diagnostics through imaging.
Organized by:
Dr. Brendon Baker,
Assistant Professor, Biomedical Engineering

Dr. David Nordsletten,
Associate Professor, Department of Biomedical Engineering and Cardiac Surgery

Zoom Link: https://umich.zoom.us/j/96508834308

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Workshop / Seminar Tue, 25 Jan 2022 13:56:46 -0500 2022-01-27T15:30:00-05:00 2022-01-27T16:30:00-05:00 Off Campus Location Biomedical Engineering Workshop / Seminar BME Seminar
The Scars of Life Course Trauma on the Immune System (January 31, 2022 12:00pm) https://events.umich.edu/event/90732 90732-21673478@events.umich.edu Event Begins: Monday, January 31, 2022 12:00pm
Location: Off Campus Location
Organized By: Institute for Social Research

The Scars of Life Course Trauma on the Immune System
by Grace Noppert

Monday, January 31
12-1:10 pm ET via Zoom

Abstract:
We are currently observing an unprecedented rise in childhood trauma from COVID-19—specifically related to the loss and disruption of caregiving. Yet, we know little about the impact or persistence of early life trauma on later life immune function. Using nationally representative data on older adults from the U.S. Health and Retirement Study, we examined the association between experiencing parental death or parental separation before the age of 16 years and four markers of immune function in late life: high sensitive C-reactive Protein (CRP), Interleukin-6 (IL-6), soluble Tumor Necrosis Factor (sTNFR), and immune response to cytomegalovirus (CMV) measured by the level of Immunoglobulin G (IgG). We also examined racial and ethnic differences in these associations. We found that racialized minority individuals were more likely to experience parental death/separation in early life compared to non-Hispanic Whites and had poorer immune function in later life. We also found consistent associations between parental death or separation and poor immune function in later life measured by both CMV and IL-6 across all race/ethnic subgroups. This presentation will discuss the growing body of evidence that early life trauma becomes embedded in the architecture of the immune system with consequences for health throughout the life course.

Bio:
Dr. Noppert's work lies at the intersection of biology, sociology, and epidemiology. Her work seeks to explain how social processes become biologically embedded with implications for health across the life course. She began her work as an infectious disease epidemiologist examining health disparities in tuberculosis (TB) in the U.S. Since then, her work has focused on uncovering the social underpinning of a range of infectious diseases, both established (e.g., TB) and emergent (e.g., SARS-CoV-2). Her current work focuses on sociobiological exposures such as persistent viral infections (e.g., CMV, HSV-1, etc.) and how they intersect with the immune system. Understanding the link between social factors, infections, and immune function may hold clues to explaining and disrupting persistent health inequities across the life course.

Michigan Population Studies Center (PSC) Brown Bag seminars highlight recent research in population studies and serve as a focal point for building our research community.

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Lecture / Discussion Tue, 18 Jan 2022 13:39:42 -0500 2022-01-31T12:00:00-05:00 2022-01-31T13:00:00-05:00 Off Campus Location Institute for Social Research Lecture / Discussion event flyer
DCM&B Tools and Technology Seminar (February 3, 2022 12:00pm) https://events.umich.edu/event/89792 89792-21665801@events.umich.edu Event Begins: Thursday, February 3, 2022 12:00pm
Location: Off Campus Location
Organized By: DCMB Tools and Technology Seminar

The MinION is a recent-to-market handheld nanopore sequencer. It can be used to determine the whole genome of a target virus in a biological sample. Its Read Until feature allows us to skip sequencing a majority of non-target reads (DNA/RNA fragments), which constitutes more than 99% of all reads in a typical sample. However, it does not have any on-board computing, which significantly limits its portability. We analyze the performance of a Read Until metagenomic pipeline for detecting target viruses and identifying strain-specific mutations. We find new sources of performance bottlenecks (basecaller in classification of a read) that are not addressed by past genomics accelerators. We present SquiggleFilter, a novel hardware accelerated dynamic time warping (DTW) based filter that directly analyzes MinION’s raw squiggles and filters everything except target viral reads, thereby avoiding the expensive basecalling step. We show that our 14.3W 13.25mm2 accelerator has 274 × greater throughput and 3481 × lower latency than existing GPU-based solutions while consuming half the power, enabling Read Until for the next generation of nanopore sequencers.

SquiggleFilter: https://github.com/TimD1/SquiggleFilter
Associated Article: https://dl.acm.org/doi/10.1145/3466752.3480117

Speaker Bio: Hari Sadasivan is a PhD candidate in CSE focusing on hardware-software co-design for accelerating healthcare solutions like genome sequencing for microbiome abundance and precision medicine.

This presentation will be given remotely, with the livestream available via Zoom.

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Presentation Thu, 20 Jan 2022 15:24:09 -0500 2022-02-03T12:00:00-05:00 2022-02-03T13:00:00-05:00 Off Campus Location DCMB Tools and Technology Seminar Presentation
Learning Health Systems: A Pathway to Sustainable Health Improvement (February 3, 2022 12:00pm) https://events.umich.edu/event/91725 91725-21682582@events.umich.edu Event Begins: Thursday, February 3, 2022 12:00pm
Location:
Organized By: Office of Research School of Dentistry

Charles Friedman is the Josiah Macy Jr. Professor of Medical Education and Chair of the Department of Learning Health Sciences at the University of Michigan Medical School. In recent years, he has focused his academic interests and activities on the concept of Learning Health Systems, and the socio-technical infrastructure required to sustain them. He is editor-in-chief of the open-access journal Learning Health Systems and co-chair of the movement to Mobilize Computable Biomedical Knowledge.

He was recently awarded an honorary doctorate by the University of Lucerne in Switzerland for his contributions to the science of Learning Health Systems.
Prior to coming to Michigan, Friedman held executive positions at the Office of the National Coordinator for Health IT (ONC) in the U.S. Department of Health and Human Services. Immediately prior to his work in the government, Dr. Friedman was Associate Vice Chancellor for Biomedical Informatics, and Founding Director of the Center for Biomedical Informatics at the University of Pittsburgh.

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Presentation Mon, 31 Jan 2022 11:39:40 -0500 2022-02-03T12:00:00-05:00 2022-02-03T13:00:00-05:00 Office of Research School of Dentistry Presentation Charles P. Friedman, PhD
Targeting and monitoring focused ultrasound in the brain with MRI (February 3, 2022 3:30pm) https://events.umich.edu/event/91561 91561-21680566@events.umich.edu Event Begins: Thursday, February 3, 2022 3:30pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: Biomedical Engineering

Abstract:
Focused ultrasound is a noninvasive therapeutic modality in which ultrasound waves are focused to a point in the body to manipulate a target without affecting intervening tissue. Some of the most promising applications for focused ultrasound are in the brain, where it is FDA-approved for thermal ablation in movement disorders, and is also being explored for blood brain barrier opening and neuromodulation. MRI plays a critical role in targeting and monitoring the effects of transcranial focused ultrasound through its ability to image not only fine brain structures but also temperature and tissue displacement. In this talk I will present our efforts to overcome the myriad technical challenges associated with MRI guidance of transcranial focused ultrasound, including achieving volumetric coverage in brain thermometry, alleviating signal voids and artifacts caused by the presence of the transducer and its coupling media, and rapidly imaging tissue displacement to localize the focus and compensate acoustic aberrations caused by the skull. 

Bio:
Will Grissom is an Associate Professor of Biomedical Engineering at Vanderbilt University. He received his PhD from the University of Michigan in 2008, completed a postdoctoral fellowship at Stanford University in 2009, and worked as a Research Engineer at GE Global Research in Munich Germany until 2011. He then joined the Department of Biomedical Engineering and the Institute of Imaging Science at Vanderbilt University where he works on RF pulse design, image reconstruction, and RF coils for MRI from 47 mT to 7 T, and develops interventional MRI methods for guiding focused ultrasound and laser ablation and neuromodulation.

Organized by:
Dr. Brendon Baker,
Assistant Professor, Biomedical Engineering

Dr. David Nordsletten,
Associate Professor, Department of Biomedical Engineering and Cardiac Surgery

Zoom Link: https://umich.zoom.us/j/96508834308
Location: 1131 LBME, 1101 Beal Ave., Ann Arbor, MI 48109-2110

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Workshop / Seminar Wed, 26 Jan 2022 15:42:01 -0500 2022-02-03T15:30:00-05:00 2022-02-03T16:30:00-05:00 Lurie Biomedical Engineering (formerly ATL) Biomedical Engineering Workshop / Seminar BME Seminar
Jeff Galvin (American Gene Technologies, CEO) - Gene and Cell Development, Genetically Modified Organisms, Software, Business (February 7, 2022 6:00pm) https://events.umich.edu/event/88951 88951-21659250@events.umich.edu Event Begins: Monday, February 7, 2022 6:00pm
Location: Off Campus Location
Organized By: Bio-Tech, Entrepreneurship, and Coding Organization

On Monday, February 07, 2022 @ 6:00PM-7:00PM ET, come virtually listen to Jeff Galvin (Harvard '81 Economics; CEO of American Gene Technologies and VP/CEO/Director of various other private and public technology companies) discuss gene therapy vs. cell therapy, recombinant DNA, how cells are grown and manipulated for commercial products, genetically modified organisms, and international business, all with connections to food, beverage, agriculture, nutrition, healthcare, and general biotechnology.

American Gene Technologies (AGT) is a private company developing and commercializing genetic medicines targeting major diseases, including HIV/AIDS, Phenylketonuria (PKU) and Hepatocellular carcinoma (liver cancer, or HCC). Its drug candidates have achieved initial proof of concept in preclinical studies, are in clinical trials, and have potential to deliver cost-effective therapies that are better targeted and more potent with fewer side effects. AGT’s drugs will treat symptomatic diseases, but are intended to provide durable cures that extend the length and improve the quality of patients’ lives using its unique gene-delivery platform.

This event is co-hosted by two student organizations: biology-focused Michigan Synthetic Biology Team ("MSBT"), business-focused Bio-Tech, Entrepreneurship, and Coding Organization ("BECO"), and engineering-focused Food Industry Student Association ("FISA"). Please navigate to MSBT's, BECO's, and FISA's respective homepages linked on this post to learn more and join their email lists.

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Workshop / Seminar Thu, 03 Feb 2022 07:20:59 -0500 2022-02-07T18:00:00-05:00 2022-02-07T19:00:00-05:00 Off Campus Location Bio-Tech, Entrepreneurship, and Coding Organization Workshop / Seminar Cells
What has the Pandemic Taught Us About the American System of Health Insurance? (February 8, 2022 10:00am) https://events.umich.edu/event/91134 91134-21676769@events.umich.edu Event Begins: Tuesday, February 8, 2022 10:00am
Location: Off Campus Location
Organized By: Osher Lifelong Learning Institute (50+)

Health insurance in the U.S. comes from many different public and private sources. This talk will consider how the coronavirus has illuminated the weaknesses (and one surprising strength) of our decentralized approach to courage.

Dr. Helen Levy is a Research Professor in the Department of Health Management and Policy; she is also a Research Professor at the Institute for Social Research and the Ford School of Public Policy. She is a Research Associate at the National Bureau of Economic Research. Before coming to the University of Michigan she was an Assistant Professor at the Harris Graduate School of Public Policy Studies at the University of Chicago and a Robert Wood Johnson Foundation Scholar in Health Policy Research at the University of California at Berkeley. In 2010 - 2011, Dr. Levy served as a Senior Economist to the President’s Council of Economic Advisers in Washington, DC.

Dr. Levy’s research interests include the causes and consequences of lacking health insurance, evaluation of public health insurance programs, and the role of health literacy in explaining disparities in health outcomes. She is a co-Investigator on the Health and Retirement Study, a long-running longitudinal study of health and economic dynamics at older ages. She is currently the recipient of a Career Development Award from the National Institute on Aging to study health literacy and health disparities among the elderly.

This is the first of five lectures to be presented once each month from February through June of 2022. A new series will start in September 2022.The next lecture in the current series will take place March 8, 2022.The title is: The Dagger in the Heart of Christianity. Learn from well-known experts about an array of interesting subjects, with an interactive Q&A period following each lecture.

Preregistration is required via the OLLI website or phone. A link to access the lecture will be e-mailed to you approximately one week prior to the first session.

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Lecture / Discussion Mon, 17 Jan 2022 15:54:02 -0500 2022-02-08T10:00:00-05:00 2022-02-08T11:30:00-05:00 Off Campus Location Osher Lifelong Learning Institute (50+) Lecture / Discussion OLLI Image
Long-term Air Pollution and Incident Dementia in U.S. (February 8, 2022 12:00pm) https://events.umich.edu/event/91240 91240-21677512@events.umich.edu Event Begins: Tuesday, February 8, 2022 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

REGISTRATION REQUIRED
https://umich.zoom.us/webinar/register/WN_d_LFab2xTmmTjHuJsfZLmg

Liuhua Shi, ScD, is Assistant Professor of Environmental Health in the Rollins School of Public Health at Emory University.

Dr. Shi's research focuses on employing massive datasets, including satellite-retrieved high resolution exposures and health data, to investigate how climate change and air pollution influence seniors' health.

More specifically, her research is focused on:
1. application of remote sensing in environmental exposure modeling (e.g., predicting high-resolution PM2.5, ozone, NO2, and temperature);
2. estimating the health consequences of exposure to air pollution and climate change;
3. estimating the link between climate change and air quality, and the mediated health impacts;
4. estimating the joint and independent health effects of air pollutant mixtures;
5. statistical modeling, e.g., causal modeling and big data approach.

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Lecture / Discussion Wed, 19 Jan 2022 13:12:34 -0500 2022-02-08T12:00:00-05:00 2022-02-08T12:50:00-05:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Air pollution and dementia
Food Literacy for All:“Beginning Farmers, Environment, and Feeding Community” (February 8, 2022 6:30pm) https://events.umich.edu/event/90247 90247-21668925@events.umich.edu Event Begins: Tuesday, February 8, 2022 6:30pm
Location: Off Campus Location
Organized By: UM Sustainable Food Systems Initiative

Launched in 2017, Food Literacy for All is a community-academic partnership course based at the University of Michigan. Structured as an evening lecture series, Food Literacy for All features different guest speakers each week to address challenges and opportunities of diverse food systems.

The course is free and open to the public. The 2022 course is virtual on Tuesday evenings at 6:30pm EST.

Food Literacy 2022 Registration: https://umich.zoom.us/webinar/register/WN_0TGY1FaMRMSW2VzuP2pPDQ

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Workshop / Seminar Fri, 21 Jan 2022 12:47:08 -0500 2022-02-08T18:30:00-05:00 2022-02-08T20:00:00-05:00 Off Campus Location UM Sustainable Food Systems Initiative Workshop / Seminar Special thanks to our co-sponsors!
Craniofacial Regeneration, Stem Cells, and Clinical Cell Therapy...Where are we now? (February 10, 2022 12:00pm) https://events.umich.edu/event/91853 91853-21683555@events.umich.edu Event Begins: Thursday, February 10, 2022 12:00pm
Location:
Organized By: Office of Research School of Dentistry

Major M. Ash Collegiate Professor of Periodontics
Department of Periodontics and Oral Medicine
University of Michigan

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Presentation Wed, 02 Feb 2022 08:43:33 -0500 2022-02-10T12:00:00-05:00 2022-02-10T13:00:00-05:00 Office of Research School of Dentistry Presentation Darnell Kaigler, Jr., D.D.S, M.S., Ph.D.
Physiologic mechanics drive contractile development in stem cell derived cardiac muscle to model genetic heart disease (February 10, 2022 3:30pm) https://events.umich.edu/event/92035 92035-21686280@events.umich.edu Event Begins: Thursday, February 10, 2022 3:30pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Physiologic mechanics drive contractile development in stem cell derived cardiac muscle to model genetic heart disease

Abstract:
Disorganized mechanics and immaturity of stem cell derived cardiomyocytes have been hurdles to reproducible applications for regenerative medicine or disease modeling. We developed a platform of micron-scale cardiac muscle bundles to control biomechanics in arrays of thousands of purified, independently contracting cardiac muscle strips on two-dimensional elastomer substrates. By defining geometry and workload in this reductionist platform, we show that myofibrillar alignment and auxotonic contractions at physiologic workload drive maturation of contractile function, calcium handling, and electrophysiology. Using transcriptomics, reporter hPSC-CMs, and quantitative immunofluorescence, these cardiac muscle bundles can be used to parse orthogonal cues in early development, including contractile force, calcium load, and metabolic signals. Additionally, the resultant organized biomechanics facilitates automated extraction of contractile kinetics from brightfield microscopy imaging, increasing the accessibility, reproducibility, and throughput of pharmacologic testing. Our lab is working toward applications of this system to understand human cardiomyopathies caused by variants that affect cardiomyocyte structure and function.

Bio:
Dr. Helms is a physician-scientist in the Division of Cardiovascular Medicine at the University of Michigan. He co-directs the Inherited Cardiomyopathy and Arrhythmia Clinic. His lab studies genetic cardiomyopathy using stem cell derived cardiomyocyte and mouse models. 

Zoom Link: https://umich.zoom.us/j/96508834308

Organized by:
Dr. Brendon Baker,
Assistant Professor, Biomedical Engineering

Dr. David Nordsletten,
Associate Professor, Department of Biomedical Engineering and Cardiac Surgery

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Workshop / Seminar Wed, 09 Feb 2022 10:16:37 -0500 2022-02-10T15:30:00-05:00 2022-02-10T16:30:00-05:00 Off Campus Location Biomedical Engineering Workshop / Seminar BME Seminar
COVID-19 and Re-Enchanting Medicine (February 11, 2022 12:00pm) https://events.umich.edu/event/91006 91006-21675422@events.umich.edu Event Begins: Friday, February 11, 2022 12:00pm
Location: Off Campus Location
Organized By: The University of Michigan Medical School Program on Health, Spirituality and Religion

The Woll Family Speaker Series on Health, Spirituality and Religion presents

Lydia Dugdale, MD, MAR (Ethics), Dorothy L. and Daniel H. Silberberg Associate Professor of Medicine, Director, Center for Clinical Medical Ethics, Associate Director of Clinical Ethics, New York Presbyterian Hospital, Columbia Vagelos College of Physician and Surgeons

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Workshop / Seminar Fri, 14 Jan 2022 07:23:59 -0500 2022-02-11T12:00:00-05:00 2022-02-11T13:00:00-05:00 Off Campus Location The University of Michigan Medical School Program on Health, Spirituality and Religion Workshop / Seminar Seminar announcement
Medical School Application workshop (February 14, 2022 5:00pm) https://events.umich.edu/event/90755 90755-21673507@events.umich.edu Event Begins: Monday, February 14, 2022 5:00pm
Location: Off Campus Location
Organized By: LSA Honors Program

Are you planning on applying to medical school this summer and want help in this process? If so, we invite you to attend this Honors Program workshop led by Stephanie Chervin, LSA Honors Program Pre-Med Advisor, to help you:

• Understand the timeline of the process from application to interview

• Choose target medical programs

• Get acquainted with the application service AMCAS

Bring your questions! This session is for current LSA Honors Program students only.

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Workshop / Seminar Mon, 10 Jan 2022 13:17:09 -0500 2022-02-14T17:00:00-05:00 2022-02-14T18:15:00-05:00 Off Campus Location LSA Honors Program Workshop / Seminar Stethoscope and Laptop Computer. Laptop computers and other kinds of mobile devices and communications technologies are of increasing importance in the delivery of health care. Photographer Daniel Sone
CANCELLED - Laura Lindberg - Quality of Abortion Reporting in the US and Pathways to Improvement (February 16, 2022 12:00pm) https://events.umich.edu/event/91431 91431-21679571@events.umich.edu Event Begins: Wednesday, February 16, 2022 12:00pm
Location: Off Campus Location
Organized By: Michigan Program in Survey and Data Science

Laura Lindberg
Principal Research Scientist, Guttmacher Institute

Dr. Laura Lindberg is a Principal Research Scientist at the Guttmacher Institute, where she has worked for nearly two decades. As a social demographer, Dr. Lindberg focuses on measuring the trends, determinants and consequences of sexual and reproductive health in the U.S. population and working to improve the quality of survey data on sexual and reproductive behaviors. She currently has two NICHD grants on measurement of core demographic constructs, abortion and contraceptive failure rates. Over the course of her career, she has conducted policy-related research on adolescent sexual behaviors, sex education, adolescent preventive services, unintended pregnancy and contraceptive use. Dr. Lindberg received her undergraduate degree from Princeton University; she earned her MA and PhD in sociology at the University of Michigan, where her favorite class was on survey research methods with Bob Groves.

Quality of Abortion Reporting in the US and Pathways to Improvement

Despite the fact that an estimated one in five pregnancies in the United States end in induced abortion, abortion remains a highly sensitive, stigmatized and thus difficult-to-measure behavior. I will present on a body of recent research designed to help to develop new techniques and improve existing methodologies for measuring abortion reporting. First, I share a series of quantitative analyses to identify the scope and correlates of abortion underreporting for three of the most commonly used national fertility surveys in the United States: the National Survey of Family Growth, the National Longitudinal Survey of Youth 1997, and the National Longitudinal Study of Adolescent to Adult Health. These analyses informed the development of new question designs were explored in cognitive interviews and experimentally tested and evaluated in a national survey. Abortion underreporting in population surveys has far-reaching implications for research in sexual and reproductive health and maternal and child health.

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Lecture / Discussion Mon, 14 Feb 2022 09:50:07 -0500 2022-02-16T12:00:00-05:00 2022-02-16T13:00:00-05:00 Off Campus Location Michigan Program in Survey and Data Science Lecture / Discussion February 16th Seminar Cancelled
Identifying & Managing Burnout (February 16, 2022 6:00pm) https://events.umich.edu/event/87834 87834-21647058@events.umich.edu Event Begins: Wednesday, February 16, 2022 6:00pm
Location: Off Campus Location
Organized By: Michigan Medicine Wellness Office

Graduate school is constant, stressful, and consumes much of our daily energy. Thankfully there is an endpoint! During graduate school, it's important to recognize and manage signs of burnout in order to get to the finish line while maintaining our mental, physical and emotional health. Join this session to learn more about recognizing and managing burnout, well-being resources and communities, and strategies for managing stress. All of the tools talked about in this session are great for getting through the grind of graduate school and beyond.

Please register to receive zoom link: https://sessions.studentlife.umich.edu/track/event/session/45697

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Well-being Mon, 04 Oct 2021 11:44:08 -0400 2022-02-16T18:00:00-05:00 2022-02-16T19:00:00-05:00 Off Campus Location Michigan Medicine Wellness Office Well-being Wellness Office Logo
DCM&B Tools and Technology Seminar (February 17, 2022 12:00pm) https://events.umich.edu/event/89794 89794-21665803@events.umich.edu Event Begins: Thursday, February 17, 2022 12:00pm
Location: Off Campus Location
Organized By: DCMB Tools and Technology Seminar

I will describe a tool to learn representations of brain activity observed with functional magnetic resonance imaging. I will show how the tool works and how it can be extended. I will use some examples to demonstrate how to decode brain activity, connect brain to behavior, and use brain scans to identify individuals.

Tool Link: https://github.com/libilab/rsfMRI-VAE

This presentation will be remote only via Zoom

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Presentation Wed, 16 Feb 2022 13:03:02 -0500 2022-02-17T12:00:00-05:00 2022-02-17T13:00:00-05:00 Off Campus Location DCMB Tools and Technology Seminar Presentation
Oral Health for All: Opportunities for Improvement and Understanding (February 17, 2022 1:00pm) https://events.umich.edu/event/91753 91753-21683050@events.umich.edu Event Begins: Thursday, February 17, 2022 1:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

Dr. Jennifer Webster-Cyriaque is the deputy director of National Institute of Dental and Craniofacial Research, National Institutes of Health. An accomplished clinician, researcher, and leader, Dr. Webster-Cyriaque had previously served as a faculty member at the University of North Carolina (UNC) schools of dentistry and medicine for more than two decades.

As a tenured full professor at UNC, Dr. Webster-Cyriaque also served as the attending on clinical service at the UNC Hospital’s dental clinic. While there, she led research into a potential etiologic agent for salivary gland disease in patients living with HIV, assessed the oral microbiome and its implications for cancer-causing viruses, and studied the impact of the oral microbiome and oral health on HIV outcomes.

In addition to her research, Dr. Webster-Cyriaque has held leadership roles as the chair/vice chair of the Oral HIV/AIDS Research Alliance, as research director at the National Dental Association Foundation, as director of postdoctoral CTSA training, along with multiple roles within the American Association for Dental, Oral, and Craniofacial Research and the International Association for Dental Research. Since 2004, she has led the UNC Malawi project and provided assistance in founding Malawi’s first dental school in 2019. Dr. Webster-Cyriaque earned her PhD in microbiology/immunology from the University of North Carolina-Chapel Hill in 1998, her DDS from SUNY Buffalo in 1992, and her BA in biology and interdisciplinary social science from SUNY Buffalo in 1988.

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Presentation Tue, 01 Feb 2022 08:51:49 -0500 2022-02-17T13:00:00-05:00 2022-02-17T14:00:00-05:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Presentation Jennifer Webster-Cyriaque, DDS, PhD
Machine Learning in Drug Development (February 17, 2022 3:30pm) https://events.umich.edu/event/92334 92334-21690196@events.umich.edu Event Begins: Thursday, February 17, 2022 3:30pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Abstract:
An undesirable side effect of drugs are cardiac arrhythmias, in particular a condition called torsades de pointes. Current paradigms for drug safety evaluation are costly, lengthy, and conservative, and impede efficient drug development. Here we combine multiscale experiment and simulation, high-performance computing, and machine learning to create an easy-to-use risk assessment diagram to quickly and reliable stratify the pro-arrhythmic potential of new and existing drugs. We capitalize on recent developments in machine learning and integrate information across ten orders of magnitude in space and time to provide a holistic picture of the effects of drugs, either individually or in combination with other drugs. We show, both experimentally and computationally, that drug-induced arrhythmias are dominated by the interplay of two currents with opposing effects: the rapid delayed rectifier potassium current and the L-type calcium current. Using Gaussian process classification, we create a classifier that stratifies safe and arrhythmic domains for any combinations of these two currents. We demonstrate that our classifier correctly identifies the risk categories of 23 common drugs, exclusively on the basis of their concentrations at 50% current block. Our study shapes the way towards establishing science-based criteria to accelerate drug development, design safer drugs, and reduce heart rhythm disorders.
Bio:
Ellen Kuhl is the Walter B. Reinhold Professor in the School of Engineering and Robert Bosch Chair of Mechanical Engineering at Stanford University. She received her PhD from the University of Stuttgart in 2000 and her Habilitation from the University of Kaiserslautern in 2004. Her area of expertise is Living Matter Physics, the design of theoretical and computational models to simulate and predict the behavior of living systems. Ellen has published more than 200 peer-reviewed journal articles, edited two books, and published a textbook on COVID-19. She is a founding member of the Living Heart Project, a translational research initiative to revolutionize cardiovascular science through realistic simulation with 400 participants from research, industry, and medicine from 24 countries. Ellen is the current Chair of the US National Committee on Biomechanics and a Member-Elect of the World Council of Biomechanics. She is a Fellow of the American Society of Mechanical Engineers and of the American Institute for Mechanical and Biological Engineering. She received the National Science Foundation Career Award in 2010, was selected as Midwest Mechanics Seminar Speaker in 2014, and received the Humboldt Research Award in 2016 and the ASME Ted Belytschko Applied Mechanics Award in 2021. Ellen is an All American triathlete, a multiple Boston, Chicago, and New York marathon runner, and a Kona Ironman World Championship finisher.

Zoom Link: https://umich.zoom.us/j/96508834308

Organized by:
Dr. Brendon Baker,
Assistant Professor, Biomedical Engineering

Dr. David Nordsletten,
Associate Professor, Department of Biomedical Engineering and Cardiac Surgery

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Workshop / Seminar Mon, 14 Feb 2022 10:57:37 -0500 2022-02-17T15:30:00-05:00 2022-02-17T16:30:00-05:00 Off Campus Location Biomedical Engineering Workshop / Seminar BME Seminar
Medical School Application Workshop (February 17, 2022 4:00pm) https://events.umich.edu/event/90756 90756-21673508@events.umich.edu Event Begins: Thursday, February 17, 2022 4:00pm
Location: Off Campus Location
Organized By: LSA Honors Program

Are you planning on applying to medical school this summer and want help in this process? If so, we invite you to attend this Honors Program workshop led by Stephanie Chervin, LSA Honors Program Pre-Med Advisor, to help you:

• Understand the timeline of the process from application to interview

• Choose target medical programs

• Get acquainted with the application service AMCAS

Bring your questions! This session is for current LSA Honors Program students only.

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Workshop / Seminar Mon, 10 Jan 2022 13:19:11 -0500 2022-02-17T16:00:00-05:00 2022-02-17T17:15:00-05:00 Off Campus Location LSA Honors Program Workshop / Seminar Stethoscope and Laptop Computer. Laptop computers and other kinds of mobile devices and communications technologies are of increasing importance in the delivery of health care. Photographer Daniel Sone