Happening @ Michigan https://events.umich.edu/list/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. [FREE- NOW ONLINE!]Great Lakes Theme Semester Presents: #LakeEffects Film Series (April 9, 2020 6:30pm) https://events.umich.edu/event/73624 73624-18272034@events.umich.edu Event Begins: Thursday, April 9, 2020 6:30pm
Location: Off Campus Location
Organized By: Great Lakes Theme Semester

Hosted by Michigan Sea Grant and co-sponsored by Great Lakes Now, this completely free series will have a different theme each night: Journeys, Shipwrecks, Invaders, Hazards, Detroit Public TV Night.

Join us every Thursday for the next five weeks now on Zoom! Join us virtually for an hour and a half screening followed by a brief Q&A with filmmakers, participants, and local experts. We hope to see you there!
https://zoom.us/j/380790681

March 12: Journeys
The Big Five Dive
Crossing Lake Huron

March 19: Shipwrecks
Project Shiphunt
November Requiem

March 26: Invaders
Making Waves

April 2: Hazards
Great Lakes, Bad Lines
The Forever Chemicals

April 9: Detroit Public TV Night
Selections from Great Lakes Now

]]>
Livestream / Virtual Mon, 01 Mar 2021 15:33:59 -0500 2020-04-09T18:30:00-04:00 2020-04-09T21:00:00-04:00 Off Campus Location Great Lakes Theme Semester Livestream / Virtual U-M LSA Great Lakes Theme Semester, Lake Effects, with topographical map of Michigan
Author Event | Stephen Kesler: Great Lakes Rocks (April 9, 2020 7:00pm) https://events.umich.edu/event/73387 73387-18214928@events.umich.edu Event Begins: Thursday, April 9, 2020 7:00pm
Location: Off Campus Location
Organized By: University of Michigan Press

***Please note that events at AADL are currently postponed indefinitely.***

The Great Lakes region contains some of Earth’s oldest rocks as well as some of its youngest geologic features. Great Lakes Rocks: 4 Billion Years of Geologic History in the Great Lakes Region tells this 4 billion-year history starting with the hills, lakes and rivers that we see today and moving back in time through the advance and retreat of the glaciers, the formation of tropical seas and reefs, the rifting that almost split North America into two parts, and ending with the volcanism and mountain building that made one of Earth’s earliest continents. This history includes strange iron-rich and salt-rich oceans, an immense meteorite impact, a super-giant lava flow, and many ore deposits that lured early European settlers into the area. It also helps us predict the geologic future of the Great Lakes region, which will likely include earthquakes, meteorite impacts, changes in our rivers, lakes, and waterfalls and, most of all, in our climate. At this event, Stephen Kesler will showcase rock samples from around the Great Lakes.

Steve Kesler earned a PhD in geology from Stanford University and has taught at Louisiana State University, University of Toronto, Instituto de Recursos Norenovables (Mexico) and University of Michigan. Since joining U-M in 1977, he and many students have gone on field trips over most of the Great Lakes region. In addition to Great Lakes Rocks, he has co-authored several other recent books including Mineral Resources, Economics and the Environment; Metals and Society; and Future Global Mineral Resources.

]]>
Lecture / Discussion Tue, 17 Mar 2020 15:23:12 -0400 2020-04-09T19:00:00-04:00 2020-04-09T20:29:00-04:00 Off Campus Location University of Michigan Press Lecture / Discussion Cover image for "Great Lakes Rocks: 4 Billion Years of Geologic History in the Great Lakes Region," by Stephen E. Kesler
Master's Thesis Defense: Mingyang Wang (April 10, 2020 10:30am) https://events.umich.edu/event/73990 73990-18460430@events.umich.edu Event Begins: Friday, April 10, 2020 10:30am
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be held via Blue Jeans. It will be linked before.

BlueJeans: https://bluejeans.com/315155702

Objectives
We have developed a novel anti-vascular technique, termed photo-mediated ultrasound therapy (PUT), which utilizes nanosecond duration laser pulses synchronized with ultrasound bursts to remove microvasculature through cavitation. The objective of the current study is to explore the potential of PUT in removing cutaneous microvessels.

Methods
The auricular blood vessels of two New Zealand white rabbits were treated by PUT with a peak negative ultrasound pressure of 0.45 MPa at 0.5 MHz, and a laser fluence of 0.056 J/cm2 at 1064 nm for 10 minutes. Blood perfusion in the treated area was measured by a commercial laser speckle imaging (LSI) system before and immediately after treatment, as well as at one hour, three days, two weeks, and four weeks post treatment. Perfusion rates of 38 individual vessels from 4 rabbit ears were tracked during this time period for longitudinal assessment.

Results
The measured perfusion rates of the vessels in the treated areas, as quantified by the relative change in perfusion rate (RCPR), showed a statistically significant decrease for all time points post treatment (p<0.001). The mean decrease in perfusion is 50.79% immediately after treatment and is 32.14% at four weeks post treatment. Immediately after treatment, the perfusion rate decreased rapidly. Following this, there was a partial recovery in perfusion rate up to 3 days post treatment, then followed by a plateau in the perfusion from 3 days to 4 weeks.

Conclusions
The study demonstrated that a single PUT treatment could significantly reduce blood perfusion by 32.14% in the skin for up to 4 weeks. With unique advantages such as low laser fluence as compared with photothermolysis and agent-free treatment as compared with PDT, PUT holds potential to be developed into a new tool for the treatment of microvessels in the skin.

Keywords: laser; ultrasound; anti-vascular treatment; skin microvessels; photo-mediated ultrasound therapy

Chair: Dr. Xueding Wang

]]>
Lecture / Discussion Fri, 27 Mar 2020 13:53:59 -0400 2020-04-10T10:30:00-04:00 2020-04-10T11:30:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
MICDE Webinar | Transmission modeling of infectious diseases and the COVID-19 outbreak (April 17, 2020 3:00pm) https://events.umich.edu/event/74261 74261-18609321@events.umich.edu Event Begins: Friday, April 17, 2020 3:00pm
Location:
Organized By: The Center for the Study of Complex Systems

A Webinar presented by the Michigan Institute for Computational Discovery & Engineering (MICDE)

This seminar will focus on differential equation transmission modeling approaches to analyze the spread of infections diseases, and how Prof. Eisenberg and her colleagues are using them to model the current COVID-19 outbreak in the State of Michigan.Their current model is helping to forecast the numbers of laboratory-confirmed cases, fatalities, hospitalized patients, and hospital capacity issues (such as ICU beds needed), and examining how social distancing can impact the spread of the epidemic.

WEBINAR LINK can be found below or at right under "Related Links".

Marisa Eisenberg has been modeling COVID-19 scenarios for the Michigan State Health Department this last month. See article on our website. Link is also below.

]]>
Livestream / Virtual Tue, 14 Apr 2020 14:30:11 -0400 2020-04-17T15:00:00-04:00 2020-04-17T16:30:00-04:00 The Center for the Study of Complex Systems Livestream / Virtual Webinar Flyer
Master's Defense: Xijia Quan (April 21, 2020 3:00pm) https://events.umich.edu/event/74183 74183-18559840@events.umich.edu Event Begins: Tuesday, April 21, 2020 3:00pm
Location:
Organized By: Biomedical Engineering

NOTICE: This event will be held via Blue Jeans. The link will be posted below.

Blue Jeans link: https://bluejeans.com/6788336326

We propose a novel optimization algorithm for radiofrequency (RF) pulse design in magnetic resonance imaging (MRI), that regularizes the magnitude and phase of the target (desired) magnetization pattern separately. This approach may be useful across applications where the relative importance of achieving accurate magnitude or phase excitation varies; for example, saturation pulses "care" only about the magnitude excitation pattern. We apply our new design to the problem of spin "prephasing" in 3D functional MRI using blood-oxygen-level-dependent (BOLD) contrast; spin prephasing pulses can mitigate the signal loss observed near air/tissue boundaries due to the presence of local susceptibility gradients. We show that our algorithm can improve the simulation performance and recover some signal in some regions with steep susceptibility gradients. In all cases, our algorithm shows better phase correction than a conventional design based on minimizing the complex difference between the target and realized patterns. The algorithm is open-source and the computation time is feasible for online applications. In addition, we evaluate the impact of the choice of (initial) excitation k-space trajectories, both in terms of trajectory type (SPINS vs extended KT points) and overall pulse duration.

Chair: Dr. Jon-Fredrik Nielsen

]]>
Lecture / Discussion Thu, 09 Apr 2020 14:11:30 -0400 2020-04-21T15:00:00-04:00 2020-04-21T16:00:00-04:00 Biomedical Engineering Lecture / Discussion BME Logo
Project Management Certification (April 26, 2020 11:00am) https://events.umich.edu/event/73563 73563-18261074@events.umich.edu Event Begins: Sunday, April 26, 2020 11:00am
Location: Ross School of Business
Organized By: Tauber Institute for Global Operations

Once again, the Tauber Institute, in conjunction with the International Project Management Association (IPMA), is sponsoring a Project Management certification class and exam for graduate business and engineering students and staff.

In order to participate, you will need to reflect upon a project management experience (for example a work project, an engineering design experience/senior capstone, Ross' MAP project, Tauber team project, etc). If you cannot make it to the classes (due to project travel, MAP, or other another class), the sessions will be recorded. Homework (mastery verification) will be required after each session.

The cost to an individual to take the exam is normally $595, however, Tauber is offering the exam at a substantial discount to non-Tauber students: $500 and to Tauber students: $150. Certification is valid for 5 years. Three certification classes will be taught by Professor Eric Svaan on the following dates:

Sunday, March 15 (noon - 4:30 pm, Ross R-0420)
Sunday, March 29 (noon - 4:30 pm, Ross R-0420)
Sunday, April 5 (noon - 4:30 pm, Ross R-0420)

The certification exam, administered by IPMA-USA is scheduled for April 26, 2020 (11:00 am) at the Ross School of Business, R-0320. Successfully passing the exam will yield IPMA's Level D certification (Certified Project Management Associate).

Over the last two years, all students who have taken the exam have passed!

Project Management is a powerful skillset to have in your toolbox as you look for full-time employment!

REGISTRATION: Please register through iMpact by clicking here:
http://myumi.ch/dO5Nl

NOTE: The $500 (for non-Tauber students) or $150 fee (for Tauber students) is non-refundable.

HOSTED BY: Tauber Institute for Global Operations. For questions about this event, please contact tauberinstitute@umich.edu or visit tauber.umich.edu.

What is IPMA Level D® (Certified Project Management Associate)? The IPMA Level D is an internationally recognized entry-level qualification in the area of project management. This designation, which demonstrates the individual's ability to understand the basics of project management, is similar to the exam-oriented, knowledge-based certifications of other major Project Management associations. For many, Level D® is the first step towards a professional project or program manager role. It is the first step in a sequence (C, B, and A) to be earned by demonstration of success in larger PM responsibility sets.

For more information,
Visit tauber.umich.edu or call 734-647-1333
Connect via email to Diana Crossley dianak@umich.edu

]]>
Class / Instruction Thu, 05 Mar 2020 10:07:18 -0500 2020-04-26T11:00:00-04:00 2020-04-26T16:30:00-04:00 Ross School of Business Tauber Institute for Global Operations Class / Instruction Photo of certificate
PhD Defense: Richard Youngblood (April 29, 2020 2:00pm) https://events.umich.edu/event/74358 74358-18666222@events.umich.edu Event Begins: Wednesday, April 29, 2020 2:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be held via Blue Jeans. The link will be posted below.

BlueJeans: https://bluejeans.com/855683101

Human pluripotent stem cells (hPSCs) differentiated into complex three-dimensional (3D) structures, referred to as ‘organoids’ due to their organ-like properties, offer ideal platforms to study human development, disease and regeneration. However, studying organ morphogenesis has been hindered by the lack of appropriate culture systems that can spatially enable cellular interactions that are needed for organ formation. Many organoid cultures rely on decellularized extracellular matrices as supportive scaffolds, which are often poorly chemically defined and allow only limited tunability and reproducibility. By contrast, engineered synthetic matrices can be tuned and optimized to mimic the embryo environment in order to enhance development and maturation of organoid cultures. Herein, this work primarily focuses on using synthetic polymer matrices to investigate how the design of biomaterials can guide key interactions guiding stem-cell decisions for the reproducible generation and control of organoid cultures.
Microporous biomaterials comprised of synthetic polymer materials were shown to guide the assembly of pancreatic progenitors into insulin-producing clusters that further developed into islet organoids. The scaffold culture facilitated cell-cell interactions enabled by the scaffold design and supported cell-mediated matrix deposition of extracellular matrix (ECM) proteins associated with the basement membrane of islet cells. Furthermore, when compared to suspension cultures, the scaffold culture showed increased insulin secretion in response to glucose stimulus indicating the development of functional β-cells. By modifying the stage that cells were seeded on scaffolds from pancreatic progenitor to pancreatic endoderm, islet organoids showed increased amounts of insulin secreted per cell. In addition, seeding scaffolds with dense clusters instead of a single suspension minimized cell manipulation during the differentiation, which was shown to be influential to the development of the islet organoids. An engineered insulin reporter further identified how mechanistic changes in vitro influenced function within individual cells by measuring insulin storage and secretion through non-invasive imaging.
hPSC-derived lung organoids (HLOs) were also evaluated for in vivo maturation on biomaterial scaffolds, where HLOs were shown improved tissue structure and cellular differentiation. Investigative studies demonstrated that scaffold pore interconnectivity and polymer degradation contributed to in vivo maturation, the size of the airway structures and the total size of the transplanted tissue. Polymer biomaterials were also developed to modulate local tissue and systemic inflammation through local delivery of human interleukin 4 (hIL-4)-expressing lentivirus. Microporous scaffold culture strategies improve organoid complexity and exert fine control over the system using engineering solutions, thus, allowing the community to build more realistic organoid tools. Taken together, the microporous scaffold culture demonstrates the feasibility to translate organoid culture to the clinic as a biomanufacturing platform.

Chair: Dr. Lonnie Shea

]]>
Lecture / Discussion Tue, 21 Apr 2020 13:21:55 -0400 2020-04-29T14:00:00-04:00 2020-04-29T15:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
RNA Center Journal Club - The architecture of SARS-CoV-2 transcriptome (May 7, 2020 4:00pm) https://events.umich.edu/event/74371 74371-18674250@events.umich.edu Event Begins: Thursday, May 7, 2020 4:00pm
Location:
Organized By: Center for RNA Biomedicine

Link to publication: https://www.cell.com/pb-assets/products/coronavirus/CELL_CELL-D-20-00765.pdf

Link to Zoom meeting: https://umich.zoom.us/j/97186405854

The RNA Journal Club meets to prepare for seminars and engage with their presenters. The Club studies and reviews the articles relating to upcoming talks. It discusses the theory, methodology and findings of a publication to develop questions for its author.

The Club meets monthly and is open to all. The Journal Club meetings are announced here https://rna.umich.edu/events/. Graduate students and post-docs in RNA research are strongly encouraged to participate. The diversity of expertise within the Club makes it particularly engaging as different perspectives are being exchanged.

The Journal Club is organized by the RNA Student & PostDoc Council. The objective of the RNA Student & PostDoc Council is to work collaboratively across disciplines, build a community and generate innovative ideas to advance RNA research and education across the University of Michigan.

]]>
Livestream / Virtual Thu, 07 May 2020 11:47:34 -0400 2020-05-07T16:00:00-04:00 2020-05-07T17:00:00-04:00 Center for RNA Biomedicine Livestream / Virtual logo
RNA Innovation Seminar, Jeffery Twiss, MD, PhD, Professor, Interim Departmental Chair, SmartState Chair in Childhood Neurotherapeutics, University of South Carolina (June 15, 2020 4:00pm) https://events.umich.edu/event/73583 73583-18263274@events.umich.edu Event Begins: Monday, June 15, 2020 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Jeffery Twiss, MD, PhD, Professor, Interim Departmental Chair, SmartState Chair in Childhood Neurotherapeutics, University of South Carolina

]]>
Lecture / Discussion Thu, 05 Mar 2020 08:43:23 -0500 2020-06-15T16:00:00-04:00 2020-06-15T17:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion lecture
Kate A. Fitzgerald, PhD, Vice Chair, Research, Department of Medicine, (July 13, 2020 4:00pm) https://events.umich.edu/event/74621 74621-18880949@events.umich.edu Event Begins: Monday, July 13, 2020 4:00pm
Location:
Organized By: Center for RNA Biomedicine

Registration link: https://umich.zoom.us/webinar/register/WN_25jkEySCT6q3UWjxfRU13Q

Keywords: lncRNA, Inante Immunity, Interferon, Antiviral

]]>
Lecture / Discussion Wed, 01 Jul 2020 11:22:18 -0400 2020-07-13T16:00:00-04:00 2020-07-13T17:00:00-04:00 Center for RNA Biomedicine Lecture / Discussion speaker photo
PhD Defense: Josiah Simeth (August 5, 2020 2:00pm) https://events.umich.edu/event/75278 75278-19402991@events.umich.edu Event Begins: Wednesday, August 5, 2020 2:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Notice: This event will be held via BlueJeans. The link will be placed below.

BlueJeans: https://bluejeans.com/715371816

Measures of regional and global liver function are critical in guiding treatments for intrahepatic cancers, and liver function is a dominant factor in the survival of patients with hepatocellular carcinoma (HCC). Global and regional liver function assessments are important for defining the magnitude and spatial distribution of radiation dose to preserve functional liver parenchyma and reduce incidence of hepatotoxicity from radiation therapy (RT) for intrahepatic cancer treatment. This individualized liver function-guided RT strategy is critical for patients with heterogeneous and poor liver function, often observed in cirrhotic patients treated for HCC. Dynamic gadoxetic-acid enhanced (DGAE) magnetic resonance imaging (MRI) allows investigation of liver function through observation of the uptake of contrast agent into the hepatocytes.

This work seeks to determine if gadoxetic uptake rate can be used as a reliable measure of liver function, and to develop robust methods for uptake estimation with an interest in the therapeutic application of this knowledge in the case of intrahepatic cancers. Since voxel-by voxel fitting of the preexisting nonlinear dual-input two-compartment model is highly susceptible to over fitting, and highly dependent on data that is both temporally very well characterized and low in noise, this work proposes and validates a new model for quantifying the voxel-wise uptake rate of gadoxetic acid as a measure of regional liver function. This linearized single-input two-compartment (LSITC) model is a linearization of the pre-existing dual-input model but is designed to perform uptake quantification in a more robust, computationally simpler, and much faster manner. The method is validated against the preexisting dual-input model for both real and simulated data. Simulations are used to investigate the effects of noise as well as issues related to the sampling of the arterial peak in the characteristic input functions of DGAE MRI.

Further validation explores the relationship between gadoxetic acid uptake rate and two well established global measures of liver function, namely: Indocyanine Green retention (ICGR) and Albumin-Bilirubin (ALBI) score. This work also establishes the relationships between these scores and imaging derived measures of whole liver function using uptake rate. Additionally, the same comparisons are performed for portal venous perfusion, a pharmacokinetic parameter that has been observed to correlate with function, and has been used as a guide for individualized liver function-guided RT. For the patients assessed, gadoxetic acid uptake rate performs significantly better as a predictor of whole liver function than portal venous perfusion.
This work also investigates the possible gains that could be introduced through use of gadoxetic uptake rate maps in the creation of function-guided RT plans. To this end, plans were created using both perfusion and uptake, and both were compared to plans that did not use functional guidance. While the plans were generally broadly similar, significant differences were observed in patients with severely compromised uptake that did not correspond with compromised perfusion.

This dissertation also deals with the problem of quantifying uptake rate in suboptimal very temporally sparse or short DGAE MRI acquisitions. In addition to testing the limits of the LSITC model for these limited datasets (both realistic and extreme), a neural network-based approach to quantification of uptake rate is developed, allowing for increased robustness over current models.

Chair: Dr. Yue Cao

]]>
Lecture / Discussion Thu, 23 Jul 2020 17:51:41 -0400 2020-08-05T14:00:00-04:00 2020-08-05T15:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
NSF GRF Webinar (September 3, 2020 4:00pm) https://events.umich.edu/event/76148 76148-19669618@events.umich.edu Event Begins: Thursday, September 3, 2020 4:00pm
Location: Off Campus Location
Organized By: Office of National Scholarships & Fellowships (ONSF)

REGISTER HERE: https://myumi.ch/wlKOk

NSF Graduate Research Fellowships provides $138,00 for research-based masters and PhD students in STEM and Social Science fields (three-year annual stipend of $34,000 along with a $12,000 cost of education allowance for tuition and fees paid to the graduate institution).

This webinar is for undergraduate seniors, 1st and 2nd year graduate students in NSF-approved fields (see the NSF-GRFP webpage for a list of fields). Rising juniors who may apply in the future are also welcome. Applicants must be US citizens or permanent residents. Applicants from backgrounds traditionally underrepresented in their fields are especially encouraged to apply. For more information about eligibility, please see this NSF video: https://vimeo.com/361402315

]]>
Livestream / Virtual Wed, 26 Aug 2020 12:25:59 -0400 2020-09-03T16:00:00-04:00 2020-09-03T17:00:00-04:00 Off Campus Location Office of National Scholarships & Fellowships (ONSF) Livestream / Virtual NSF Webinar
RNA Collaborative Seminar featuring: Sue Hammoud, Human Genetics & Justin Colacino, Environmental Health Sciences (September 9, 2020 4:00pm) https://events.umich.edu/event/75865 75865-19615931@events.umich.edu Event Begins: Wednesday, September 9, 2020 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

ZOOM REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_GjVNcoWtRG6OkzxSDmfb8A

"Same Same Different: Single cell RNAseq identifies conserved and divergent features of mammalian spermatogenesis"
Sue Hammoud, Ph.D.
Assistant Professor of Human Genetics
Website: https://hammoud.lab.medicine.umich.edu/

~and~

"Single cell transcriptomic profiling to understand breast stem cell heterogeneity in development and cancer disparities"
Justin Colacino. Ph.D.
Assistant Professor of Environmental Health Sciences
Website: https://www.colacinolab.com/

]]>
Lecture / Discussion Wed, 26 Aug 2020 11:44:32 -0400 2020-09-09T16:00:00-04:00 2020-09-09T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion RNA Collaborative
Identifying Emergency Funds and How to Advocate for Making Room in Your Financial Aid Package (September 11, 2020 2:00pm) https://events.umich.edu/event/75507 75507-19513173@events.umich.edu Event Begins: Friday, September 11, 2020 2:00pm
Location: Off Campus Location
Organized By: CEW+

Advance registration is required; look for the Zoom link at the bottom of your confirmation email after registering.

This session will provide information about how you can seek emergency funds should you experience an emergency situation or one-time, unusual, unforeseen expense while in school. Information about the types of situations that qualify for emergency funds and where to seek funding will be covered during this presentation.

RSVP HERE: http://www.cew.umich.edu/events/identifying-emergency-funds-and-how-to-advocate-for-making-room-in-your-financial-aid-package

]]>
Livestream / Virtual Tue, 18 Aug 2020 14:02:34 -0400 2020-09-11T14:00:00-04:00 2020-09-11T15:00:00-04:00 Off Campus Location CEW+ Livestream / Virtual A jar of spilled change
RNA Seminar featuring: Andrey Krasilnikov, Penn State (September 21, 2020 4:00pm) https://events.umich.edu/event/75802 75802-19608017@events.umich.edu Event Begins: Monday, September 21, 2020 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

ZOOM REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_obckKUCLT4mXI7kPskzc-Q

KEYWORDS: Ribozymes, RNase P, RNase MRP, ribonucleoprotein complexes, RNA-driven protein remodelling

ABSTRACT: Ribonuclease (RNase) P is a ribozyme-based catalytic ribonucleoprotein complex involved primarily in the maturation of tRNA in all three domains of life. In the course of evolution, the size and complexity of RNase P grew as the catalytic RNA moiety recruited additional protein components. In eukaryotes, the RNase P lineage has split, giving rise to a related RNP enzyme called RNase MRP, which shares multiple structural features (including most of the protein components) with the eukaryotic RNase P, but has a distinct and non-overlapping specificity. We report the recently solved cryo-EM structure of the 450 kDa yeast RNase MRP holoenzyme and compare it with the structure of its progenitor RNP, RNase P. We show that, surprisingly, several of the proteins shared by RNase MRP and RNase P undergo RNA-driven structural remodeling, allowing the same proteins to function in distinct structural contexts. This remodeling, combined with altered peripheral RNA elements, results in the functional diversification of the two closely related RNPs, in spite of the structural conservation of the nearly identical catalytic cores, demonstrating structural underpinnings of the acquisition of new functions by catalytic RNPs.

]]>
Lecture / Discussion Thu, 17 Sep 2020 07:12:03 -0400 2020-09-21T16:00:00-04:00 2020-09-21T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Andrey Krasilnikov, Penn State
Complex Systems Seminar | The Ranking Game from a Hungarian Perspective (September 22, 2020 11:30am) https://events.umich.edu/event/76900 76900-19776605@events.umich.edu Event Begins: Tuesday, September 22, 2020 11:30am
Location: Off Campus Location
Organized By: The Center for the Study of Complex Systems

ZOOM MEETING LINK: https://umich.zoom.us/j/96616169868

Abstract:
We like to see who is stronger, richer, better, more clever. Since we
humans (1) love lists; (2), are competitive and (3), are jealous of
other people, we like ranking. Ranking reflects the reality, illusion and
manipulation of objectivity.

The book "Ranking: The Unwritten Rules of the Social Game We All Play" is offered to people whose neighbor has a fancier car; employees, who are being ranked by their supervisors; managers, who are involved in ranking but may have qualms about the process; businessmen interested in creating better visibility for their companies; scientists, writers, artists, and other competitors who would like to see themselves at the top of a success list; college students who are just preparing to enter the new phase of social competition. The lecture will mirror the speaker's education and experiences in Pest and Buda.

]]>
Livestream / Virtual Tue, 08 Sep 2020 20:19:09 -0400 2020-09-22T11:30:00-04:00 2020-09-22T13:00:00-04:00 Off Campus Location The Center for the Study of Complex Systems Livestream / Virtual Peter Erdi Headshot
RNA Seminar featuring: Hiroaki Suga, University of Tokyo (September 28, 2020 9:00am) https://events.umich.edu/event/75805 75805-19608020@events.umich.edu Event Begins: Monday, September 28, 2020 9:00am
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

ZOOM REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_PBHPayAvR8WobaSf3z0AUA

ABSTRACT: Macrocyclic peptides possess a number of pharmacological characteristics distinct from other well-established therapeutic molecular classes, resulting in a versatile drug modality with a unique profile of advantages. Macrocyclic peptides are accessible by not only chemical synthesis but also ribosomal synthesis. Particularly, recent inventions of the genetic code reprogramming integrated with an in vitro display format, referred to as RaPID (Random non-standard Peptides Integrated Discovery) system, have enabled us to screen mass libraries (>1 trillion members) of non-standard peptides containing multiple non-proteinogenic amino acids, giving unique properties of peptides distinct from conventional peptides, e.g. greater proteolytic stability, higher affinity (low nM to sub nM dissociation constants similar to antibodies), and superior pharmacokinetics. The field is rapidly growing evidenced by increasing interests from industrial sectors, including small start-ups as well as mega-pharmas, toward drug development efforts on macrocyclic peptides, which has led to several de novo discovered peptides entering clinical trials. This lecture discusses the aforementioned screening technology involving the method of “genetic code reprogramming” powered by flexizymes, and several showcases of therapeutic potentials of macrocyclic peptides.

]]>
Lecture / Discussion Sun, 20 Sep 2020 13:22:07 -0400 2020-09-28T09:00:00-04:00 2020-09-28T10:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Hiroaki Suga, University of Tokyo
U-M STEM Research Career Award (September 29, 2020 4:00pm) https://events.umich.edu/event/75324 75324-19440266@events.umich.edu Event Begins: Tuesday, September 29, 2020 4:00pm
Location: Off Campus Location
Organized By: Office of National Scholarships & Fellowships (ONSF)

The U-M STEM Research Career Award supports highly qualified students who plan to pursue a PhD and research career in a STEM fields.

The scholarship provides $5000 for summer research or other academic expenses. The scholarship does not require US citizenship; it is open to students from all nationalities and backgrounds. The U-M STEM Research Career Award application and letters of recommendation will also be used to select U-M’s nominees for the Goldwater and Astronaut Scholarships from among eligible applicants.

Register: https://myumi.ch/bvnN2

Learn more: https://lsa.umich.edu/onsf/scholarships/stem-biomedical/u-m-stem-research-career-award.html

]]>
Livestream / Virtual Tue, 28 Jul 2020 09:44:44 -0400 2020-09-29T16:00:00-04:00 2020-09-29T17:00:00-04:00 Off Campus Location Office of National Scholarships & Fellowships (ONSF) Livestream / Virtual Microscope
PD Soros Fellowship for New Americans (September 29, 2020 7:00pm) https://events.umich.edu/event/75316 75316-19434382@events.umich.edu Event Begins: Tuesday, September 29, 2020 7:00pm
Location: Off Campus Location
Organized By: Office of National Scholarships & Fellowships (ONSF)

The Paul and Daisy Soros Fellowship for New Americans provides up to two years of graduate study in any field and in any graduate degree-granting program in the United States. Each award is for up to $25,000 in stipend support, as well as 50 percent of required tuition and fees, up to $20,000 per year, for two years. The total value of the fellowship is $90,000.

Register: https://myumi.ch/bvnN2

Learn more: https://lsa.umich.edu/onsf/scholarships/united-states/the-paul---daisy-soros-fellowships.html

]]>
Livestream / Virtual Thu, 27 Aug 2020 12:19:56 -0400 2020-09-29T19:00:00-04:00 2020-09-29T20:00:00-04:00 Off Campus Location Office of National Scholarships & Fellowships (ONSF) Livestream / Virtual PD Soros Fellows 2020
Physics Special Department Colloquium | Scientific Espionage, Open Exchange, and American Competitiveness (September 30, 2020 4:00pm) https://events.umich.edu/event/76450 76450-19717145@events.umich.edu Event Begins: Wednesday, September 30, 2020 4:00pm
Location: Off Campus Location
Organized By: Department of Physics

In 2015, Xiaoxing Xi was wrongfully arrested by the FBI in a case of alleged racial profiling. Since speaking out about his experience and the consequences for academic freedom, he was awarded the 2020 Andrei Sakharov Prize from the American Physical Society, which is awarded biannually to human rights advocates in the physics community.

Presentation abstract:
Amid rapidly escalating tension between the United States and China, professors, scientists, and students of Chinese ethnic origin as well as those engaging in academic collaborations with China are under heightened scrutiny by the federal government. Law enforcement officials consider collaborating with Chinese colleagues “by definition conveying sensitive information to the Chinese.” In 2015, I became a casualty of this campaign despite being innocent. This experience gave me insights into the challenges Chinese scientists face and the immediate threat to the open environment in fundamental research on university campuses.

In this talk, I will highlight the JASON Report on Fundamental Research Security, commissioned and endorsed by the National Science Foundation. It opposes profiling Chinese scholars based on the actions of the Chinese government and Chinese Communist Party, supports reaffirmation of NSDD-189, which made unrestricted fundamental research a federal policy and proposes addressing foreign influence on US research within the framework of research integrity. I urge the audience to rally around the JASON Report and speak up to defend liberty and safeguard America's research enterprise.

Co-sponsored by Indigo: The LSA Asian and Asian-American Faculty Alliance and the U-M Association of Chinese Professors.

Please register here for the webinar: https://umich.zoom.us/webinar/register/WN_5ZfAAGdLTgylS04ds7ayuw

]]>
Presentation Thu, 24 Sep 2020 14:13:32 -0400 2020-09-30T16:00:00-04:00 2020-09-30T17:00:00-04:00 Off Campus Location Department of Physics Presentation Event Poster
Saturday Morning Physics VIRTUAL Event | Exploring Titan with Dragonfly! (October 3, 2020 10:30am) https://events.umich.edu/event/77279 77279-19830131@events.umich.edu Event Begins: Saturday, October 3, 2020 10:30am
Location: Off Campus Location
Organized By: Saturday Morning Physics

Youtube Event Link: https://www.youtube.com/watch?v=y4dh-dv4AxQ
(Link will be active at 10:30 am on 10/3/20.) See saturdaymorningphysics.org for more details.

Dr. Ann Parsons will give a "live" lecture with a "live" Q&A after the talk.

NASA has recently selected the Dragonfly Mission to study the surface chemistry of Saturn’s largest moon, Titan! Dragonfly will land on Titan and then fly to dozens of different locations over its surface to study its prebiotic chemistry and to look for potential biosignatures.

We celebrate the James Robert Walker Lecture on this occasion.

]]>
Workshop / Seminar Tue, 22 Sep 2020 16:05:39 -0400 2020-10-03T10:30:00-04:00 2020-10-03T11:30:00-04:00 Off Campus Location Saturday Morning Physics Workshop / Seminar Dragonfly Mission Image
Complex Systems Seminar | A Simple Model for a Complex System: Legged Locomotion as an Oscillator (October 6, 2020 11:30am) https://events.umich.edu/event/77060 77060-19790568@events.umich.edu Event Begins: Tuesday, October 6, 2020 11:30am
Location: Off Campus Location
Organized By: The Center for the Study of Complex Systems

VIRTUAL SEMINAR LINK: myumi.ch/v2ZYv

The neuromechanical control and dynamics of legged locomotion are of great interest for biomedical and robotics applications, as well as being an aspect of functional morphology with large ecological implications. Most biomechanists take a "reductionist" approach that attempts to model animal motion by modeling the parts of the organism and their interconnections, thereby combining them into what are sometimes staggeringly complex models. We will discuss a complementary "essentialist" approach, where multi-legged locomotion is viewed as a limit cycle oscillation comprising the body, nervous system, and environment. Through a combination of theoretical mathematical advances, new numerical algorithms, and experimental work on both animals and robots, this approach has revealed new ways to non-invasively inspect neuromechanical feedback pathways, control and coordinate legs, and model complex multi-contact collisions. Talk will be non-technical and suitable for a broad sciences audience.

]]>
Livestream / Virtual Wed, 30 Sep 2020 11:43:45 -0400 2020-10-06T11:30:00-04:00 2020-10-06T13:00:00-04:00 Off Campus Location The Center for the Study of Complex Systems Livestream / Virtual Headshot Shai Revzen
Hands-on Workshop: Creating a Hybrid Simulation System Using the Simple Run Time Infrastructure Software (October 9, 2020 4:00pm) https://events.umich.edu/event/76684 76684-19735053@events.umich.edu Event Begins: Friday, October 9, 2020 4:00pm
Location: Off Campus Location
Organized By: Michigan Institute for Computational Discovery and Engineering

The goal of this hands-on workshop is to introduce the Simple Run-Time Infrastructure software toolkit (SRTI) to the participants, and provide a template project consisting of multiple simulators, each with a specialized purpose, relating to a natural-disaster scenario. It will take place after the feature talks.

The SRTI is a free, open-source solution developed at the University of Michigan, and enables researchers to connect computer programs and simulators written in different languages, to share data during execution, and to design hybrid systems using disparate simulator modules, with a primary goal of being user friendly. This hands-on workshop will explain what the SRTI is, and provide an example on how to use it.

The Java Runtime Environment (JRE) is required to run the SRTI. Please install it prior to the workshop. Refer to icor.engin.umich.edu for more information on supported operating systems and languages. Participants will need to use their own computer systems at home to take part. Basic coding skills in any programming language are required.

Open to the general public. Please register if you wish to participate.

]]>
Workshop / Seminar Thu, 03 Sep 2020 16:10:17 -0400 2020-10-09T16:00:00-04:00 2020-10-09T18:00:00-04:00 Off Campus Location Michigan Institute for Computational Discovery and Engineering Workshop / Seminar Creating a Hybrid Simulation System Using the Simple Run Time Infrastructure Software
Saturday Morning Physics VIRTUAL Event | The Degree of Fine-Tuning in our Universe – and Others (October 10, 2020 10:30am) https://events.umich.edu/event/77280 77280-19830132@events.umich.edu Event Begins: Saturday, October 10, 2020 10:30am
Location: Off Campus Location
Organized By: Saturday Morning Physics

Professor Fred Adams will give a pre-recorded lecture with a "live" Q&A after the talk.

Youtube Event Link: https://www.youtube.com/watch?v=jPs7-svpZW8 (Link will be active at 10:30 am on 10/10/20.) See saturdaymorningphysics.org for more details.

The fundamental constants of nature must fall within a range of values in order for the universe to develop structure and ultimately support life. The relevant parameters include the strengths of the fundamental forces, particle masses, cosmic energy densities, abundances of ordinary matter and dark matter, and the amplitude of primordial density fluctuations. This talk considers current constraints on these quantities and assesses the degree of tuning required for the universe to be viable.

]]>
Workshop / Seminar Mon, 05 Oct 2020 08:16:09 -0400 2020-10-10T10:30:00-04:00 2020-10-10T23:30:00-04:00 Off Campus Location Saturday Morning Physics Workshop / Seminar Saturday Morning Physics Talk Photo
Science Success Series | Overcoming the Fear of Failure in Personal and Academic Pursuits (October 12, 2020 3:00pm) https://events.umich.edu/event/76330 76330-19687523@events.umich.edu Event Begins: Monday, October 12, 2020 3:00pm
Location: Off Campus Location
Organized By: Science Learning Center

In this workshop, we'll build on the lessons of growth mindset and put failure into practice, with activities that allow us to focus on the learning that goes along with mistakes. This way, we can create environments that allow for innovation, personal, and professional growth.

Register on Sessions: https://sessions.studentlife.umich.edu/track/event/session/29116

Email ScienceSuccessSeries@umich.edu with any questions.

]]>
Workshop / Seminar Fri, 28 Aug 2020 17:08:58 -0400 2020-10-12T15:00:00-04:00 2020-10-12T16:30:00-04:00 Off Campus Location Science Learning Center Workshop / Seminar
NeuroNetwork for Emerging Therapies Mini Symposium Series: Climate Change, the Environment & Health (October 15, 2020 2:00pm) https://events.umich.edu/event/77387 77387-19846079@events.umich.edu Event Begins: Thursday, October 15, 2020 2:00pm
Location: Off Campus Location
Organized By: NeuroNetwork for Emerging Therapies

It is impossible to ignore the evidence of the past decade - wildfires have made air on the west coast incredibly hazardous and children have been poisoned by drinking water at crucial ages of development. The environment we have created for ourselves is a serious threat to our health.

Eva Feldman, MD, PhD, Director of the NeuroNetwork for Emerging Therapies, will moderate the 30-minute mini symposium that discusses both global and local impacts that the environment has on our health. Along with Dr. Feldman, presentations will be made by Jonathan Overpeck, PhD, Dean of the School for Environment and Sustainability, who will address climate change and environmental justice; Stuart Batterman, PhD, a professor from the U-M School of Public Health, who will discuss how contaminants in the air affect your health; and Stephen Goutman, MD, MS, director of the Pranger ALS Clinic, who will talk about the association between environmental pollution and ALS.

]]>
Conference / Symposium Thu, 17 Sep 2020 17:26:08 -0400 2020-10-15T14:00:00-04:00 2020-10-15T14:30:00-04:00 Off Campus Location NeuroNetwork for Emerging Therapies Conference / Symposium Climate Change, the Environment & Health Mini Symposium
Saturday Morning Physics VIRTUAL Event | Smart Maritime Propulsion and Energy Harvesting Concepts (October 17, 2020 10:30am) https://events.umich.edu/event/77281 77281-19830134@events.umich.edu Event Begins: Saturday, October 17, 2020 10:30am
Location: Off Campus Location
Organized By: Saturday Morning Physics

Professor Julie Young will give a pre-recorded lecture with a "live" Q&A after the talk.

YouTube Event Link: https://www.youtube.com/watch?v=zey20C9_c1M
(Link will be active at 10:30 am on 10/17/20.) See saturdaymorningphysics.org for more details.

Some of the topics covered in this talk include, how can we design smart marine propulsion and energy harvesting devices to keep our oceans blue? What are the interesting physics fundamentals that govern how bodies move in water? How can we take advantage of advances in materials, manufacturing, sensing, and control?

]]>
Workshop / Seminar Tue, 22 Sep 2020 16:08:28 -0400 2020-10-17T10:30:00-04:00 2020-10-17T11:30:00-04:00 Off Campus Location Saturday Morning Physics Workshop / Seminar Saturday Morning Physics Logo
CSCS/MIDAS/CSS Seminar | Towards An Artificial Intuition: Conversational Markers Of (Anti)Social Dynamics (October 19, 2020 4:00pm) https://events.umich.edu/event/77798 77798-19933614@events.umich.edu Event Begins: Monday, October 19, 2020 4:00pm
Location: Off Campus Location
Organized By: The Center for the Study of Complex Systems

MEETING LINK: https://umich.zoom.us/j/95443347994

Abstract: Can conversational dynamics—the nature of the back and forth between people—predict outcomes of social interactions? This talk will describe efforts on developing an artificial intuition about ongoing conversations, by modeling the subtle pragmatic and rhetorical choices of the participants.

The resulting framework distills emerging conversational patterns that can point to the nature of the social relation between interlocutors, as well as to the future trajectory of this relation. For example, I will discuss how interactional dynamics can be used to foretell whether an online conversation will stay on track or eventually derail into personal attacks, providing community moderators several hours of prior notice before an anti-social event is likely to occur.

The data and code are available through the Cornell Conversational Analysis Toolkit (ConvoKit): http://convokit.cornell.edu

This talk includes joint work with Jonathan P. Chang, Lucas Dixon, Liye Fu, Yiqing Hua, Dan Jurafsky, Lillian Lee, Jure Leskovec, Vlad Niculae, Chris Potts, Arthur Spirling, Dario Taraborelli, Nithum Thain, and Justine Zhang.

Bio: Cristian Danescu-Niculescu-Mizil is an associate professor in the information science department at Cornell University. His research aims at developing computational methods that can lead to a better understanding of our conversational practices, supporting tools that can improve the way we communicate online. He is the recipient of several awards—including an NSF CAREER Award, the WWW 2013 Best Paper Award, a CSCW 2017 Best Paper Award, and two Google Faculty Research Awards—and his work has been featured in popular media outlets such as The Wall Street Journal, NBC’s The Today Show, NPR and the New York Times.

]]>
Livestream / Virtual Mon, 28 Sep 2020 12:50:36 -0400 2020-10-19T16:00:00-04:00 2020-10-19T17:00:00-04:00 Off Campus Location The Center for the Study of Complex Systems Livestream / Virtual Cristian Danescu-Niculescu-Mizil
RNA Seminar featuring: Gene Yeo, University of California, San Diego (October 19, 2020 4:00pm) https://events.umich.edu/event/75807 75807-19608023@events.umich.edu Event Begins: Monday, October 19, 2020 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

ZOOM REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_CcI2trSATJy47aGtwrzhew

Abstract: The life-cycle of RNA from transcription to translational regulation is mediated by a diverse (>2000) set of proteins called RNA binding proteins. My lab studies the many roles that RNA binding proteins have in affecting RNA expression, splicing, transport and translation. Through our studies on RNA processing, we have introduced therapeutic strategies to treat neurodegenerative and muscular diseases, built cellular models of neurodevelopmental and neurodegenerative diseases and developed experimental and computational tools that enable the community to probe RNA binding protein-RNA interactions at scale. I will discuss (1) our established and new technologies to identify RNA targets of human RBPs at scale, (2) systematic assays to assign molecular roles to RBPs and (2) functional screens to identify RBPs implicated in cancer / RNA granule formation.

]]>
Lecture / Discussion Wed, 16 Sep 2020 09:57:16 -0400 2020-10-19T16:00:00-04:00 2020-10-19T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Gene Yeo, University of California, San Diego
CSCS/MIDAS/MICDE Seminar | Predicting the second wave of COVID-19 in Washtenaw County, MI (October 20, 2020 11:30am) https://events.umich.edu/event/76629 76629-19733025@events.umich.edu Event Begins: Tuesday, October 20, 2020 11:30am
Location: Off Campus Location
Organized By: The Center for the Study of Complex Systems

This seminar is co-sponsored by the Michigan Institute for Computational Discovery & Engineering (MICDE) and the Michigan Institute for Data Science (MIDAS)

VIRTUAL SEMINAR LINK: myumi.ch/v2ZYv

In this work, we study and predict the spread of COVID-19 in Washtenaw County, MI through applying a discrete and stochastic network-based modeling framework. In this framework, we construct contact networks based on synthetic population datasets specific for Washtenaw County that are derived from US Census datasets. We assign individuals to households, workplaces, schools, and group quarters (such as prisons or long term care facilities). In addition, we assign casual contacts to each individual at random. Using this framework, we explicitly simulate Michigan-specific government-mandated workplace and school closures as well as social distancing measures. We perform sensitivity analyses to identify key model parameters and mechanisms contributing to the observed disease burden in the three months following the first observed cases of COVID-19 in Michigan. We then consider several scenarios for relaxing restrictions and reopening workplaces to predict what actions would be most prudent. In particular, we consider the effects of 1) different timings for reopening, and 2) different levels of workplace vs. casual contact re-engagement. Through simulations and sensitivity analyses, we explore mechanisms driving the magnitude and timing of a second wave of infections upon re-opening.

This work is based on Dr. Renardy's *paper in press* in the *Journal of Theoretical Biology* with coauthors:
Marisa Eisenberg, UM Complex Systems & Math (LSA) and Epidemiology (Public Health)
Denise Kirschner, UM Department of Microbiology & Immunology (Medical School)

]]>
Livestream / Virtual Mon, 28 Sep 2020 14:00:42 -0400 2020-10-20T11:30:00-04:00 2020-10-20T13:00:00-04:00 Off Campus Location The Center for the Study of Complex Systems Livestream / Virtual Photo of Marissa Renardy
Rackham/Sweetland Workshops on Writing (October 22, 2020 9:00am) https://events.umich.edu/event/78490 78490-20052309@events.umich.edu Event Begins: Thursday, October 22, 2020 9:00am
Location: Off Campus Location
Organized By: Sweetland Center for Writing

This workshop offers students tips and ideas for writing more competitive fellowship proposalsin STEM disciplines. The workshop will include an overview of the types of criteria that reviewers use in evaluating proposals as well as ideas for what to include in your proposal and how to structure content.

Presented by Larissa Sano, Sweetland Center for Writing

]]>
Workshop / Seminar Tue, 13 Oct 2020 12:36:06 -0400 2020-10-22T09:00:00-04:00 2020-10-22T10:30:00-04:00 Off Campus Location Sweetland Center for Writing Workshop / Seminar
Special Physics Presentation | Science Policy: The View from the Trenches (October 23, 2020 2:00pm) https://events.umich.edu/event/77753 77753-19909895@events.umich.edu Event Begins: Friday, October 23, 2020 2:00pm
Location: Off Campus Location
Organized By: Department of Physics

Presentation Link: http://myumi.ch/zxWXV

What if you could erase the board and redesign APS lobbying and advocacy from scratch? What issues would you work on, what techniques would you deploy? That’s precisely the position the APS Office of Government Affairs found itself in nearly four years ago. The talk will describe the circumstances APS faced, and how we responded, focusing on particular APS campaigns that successfully pushed back against federal proposals for deep cuts to R&D funding and for a new tax on graduate students. The talk will then consider current issues and how APS is now using the grassroots-based approach it developed to advance legislation on STEM visa-reform and to pass legislation in the House of Representatives to address sexual harassment in STEM.

Bio:
Francis Slakey is the Chief External Affairs Officer of the American Physical Society, overseeing the governmental, international, and industrial activities of APS.

Dr. Slakey received his Ph.D. in Physics in 1992 from the University of Illinois, Urbana-Champaign and was the Upjohn Lecturer on Science and Public Policy at Georgetown University where he founded the Program on Science in the Public Interest. He served in advisory positions for a diverse set of organizations including the National Geographic, the Council on Foreign Relations, the International Panel on Solutions to Sustainability, the Creative Coalition, and the Center for Strategic and International Studies. He is a Fellow of the American Physical Society, a Fellow of the American Association for the Advancement of Science, a MacArthur Scholar, and a Lemelson Research Associate of the Smithsonian Institution.

Dr. Slakey became the 28th American to summit Mt. Everest in an unguided environmental expedition that was the subject of the movie "Beyond the Summit", described in his international best-selling adventure memoir “To The Last Breath.” He is the first person in history to both summit the highest mountain on every continent and surf every ocean. In recognition of his adventures, as part of the 2002 Olympic Games, he carried the Olympic torch from the steps of the U.S. Capitol.

]]>
Livestream / Virtual Fri, 23 Oct 2020 08:12:32 -0400 2020-10-23T14:00:00-04:00 2020-10-23T15:00:00-04:00 Off Campus Location Department of Physics Livestream / Virtual Photo of Francis Slakey
RNA Seminar featuring: Aleksandra Filipovska, University of Western Australia (October 26, 2020 9:00am) https://events.umich.edu/event/75809 75809-19608025@events.umich.edu Event Begins: Monday, October 26, 2020 9:00am
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

ZOOM REGISTRATION REQUIRED:https://umich.zoom.us/webinar/register/WN_f8wC8rrJQzuhYzTEXoW69Q

ABSTRACT:Mitochondria produce more than 90% of the energy required by our bodies and thereby have a fundamental role in cell and energy metabolism. Mitochondria are composed of proteins encoded by both the nuclear and mitochondrial genomes and the coordinated expression of both genomes is essential for energy production. Impaired energy production leads to mitochondrial dysfunction that causes or contributes significantly to a variety of diseases including metabolic disorders and cardiovascular diseases. Mitochondrial dysfunction is caused by mutations in nuclear or mitochondrial genes that encode proteins or regulatory RNAs essential for mitochondrial biogenesis. How uncoordinated gene expression causes mitochondrial dysfunction and compromised energy production in heart and metabolic diseases is poorly understood, making it difficult to develop effective treatments. To unravel how mitochondrial function fails and to identify therapeutic targets it is necessary (i) to understand how gene expression is regulated between mitochondria and the nucleus and (ii) how this regulation is disrupted in disease. We have created new and unique models of metabolic and cardiovascular diseases caused by mutations or loss of nuclear encoded RNA-binding proteins (RBPs) that regulate mitochondrial RNA metabolism and protein synthesis. These new models have identified that energy dysfunction can differentially affect specific organs such as the heart or liver, or multiple organs leading to heart failure or metabolic diseases that can be devastating, such as mitochondrial diseases, or may be as common as insulin resistance and obesity. I will discuss the mechanisms behind these diverse pathologies caused by impaired gene expression and energy dysfunction in heart and metabolic disease.

KEYWORDS: mitochondria, RNA, ribosomes, translation

]]>
Lecture / Discussion Tue, 20 Oct 2020 14:16:54 -0400 2020-10-26T09:00:00-04:00 2020-10-26T10:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion photo
Complex Systems & Weinberg Institute Seminar | Computational Social Neuroscience (October 27, 2020 11:30am) https://events.umich.edu/event/77456 77456-19854044@events.umich.edu Event Begins: Tuesday, October 27, 2020 11:30am
Location: Off Campus Location
Organized By: The Center for the Study of Complex Systems

VIRTUAL SEMINAR LINK: myumi.ch/v2ZYv

This virtual seminar is cosponsored by the Weinberg Institute for Cognitive Science.

By interweaving multiple neurobehavioral systems, social behavior is a compelling paradigm for the science of complexity. Social behavior is also deeply intertwined with the evolution of cognition and mental health, therefore its understanding has numerous applied utilities that span adult work performance, (un)healthy socio-cognitive aging, children's cognitive development, and even human-machine interactions. I will introduce the empirical and conceptual foundations, mathematical bases and usage of neurocomputational models of social coordination that builds up from a simple model of oscillatory coupling: the Haken-Kelso-Bunz (HKB) model. The model was built from the broadly interdisciplinary intellectual foundations of a legion of dynamical system scientists at Florida Atlantic University's Center for Complex Systems and Brain Sciences, whose work have provided breakthrough for nonlinear coupling, symmetry breaking, discreteness, labile and persistent adaptation and biases. I will discuss merits, liabilities and complementarities between such a paradigm that puts genuine dynamics first, and defers a realistic functional outcome, versus other approaches that start at the top from life-like socio-cognitive architectures. I hope that a conclusion will steer the assembly into a discussion on its hidden premise: that similar dynamical phenomenology at multiple neural, behavioral and social scales speaks to universal laws of complexity across those scales whose discovery is ongoing.

]]>
Livestream / Virtual Wed, 21 Oct 2020 12:43:45 -0400 2020-10-27T11:30:00-04:00 2020-10-27T13:00:00-04:00 Off Campus Location The Center for the Study of Complex Systems Livestream / Virtual Emmanuelle Tognoli
Complex Systems Seminar | Choice of Fitness Function Matters. Which One Do Salmon Use? (November 10, 2020 11:30am) https://events.umich.edu/event/79035 79035-20178450@events.umich.edu Event Begins: Tuesday, November 10, 2020 11:30am
Location: Off Campus Location
Organized By: The Center for the Study of Complex Systems

MEETING LINK: https://umich.zoom.us/j/96616169868

Joint work with:
James Breck, Edward Rutherford, and Bobbi Low

Abstract: Life history theory focuses on characteristics of organisms, such as size and age at maturity or tradeoffs between egg number and egg size. It studies how such traits vary as evolutionary responses to natural selection that optimize fitness. One needs to know such characteristics to understand behavior and to design successful conservation strategies. A critical step in such studies is to have the right fitness function. Most theoretical ecologists concerned with life history traits work with one of the classic fitness functions: the intrinsic rate of natural increase r, the net reproductive number R₀, or Fisher’s reproductive value of a female of age x, Vₓ. Their choice among these three is sometimes driven by mathematical parsimony. Working with semelparous and iteroparous Great Lakes salmon, we find that different fitness functions can lead to very different adaptive behaviors to environmental changes. This observation sheds light on just which fitness function may be operational for a given species.

]]>
Livestream / Virtual Thu, 29 Oct 2020 15:00:24 -0400 2020-11-10T11:30:00-05:00 2020-11-10T13:00:00-05:00 Off Campus Location The Center for the Study of Complex Systems Livestream / Virtual Carl P. Simon
Of Moms and Microbes: Pregnancy and the Microbiome (November 10, 2020 12:00pm) https://events.umich.edu/event/79039 79039-20178452@events.umich.edu Event Begins: Tuesday, November 10, 2020 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Kimberly McKee, PhD, Assistant Professor of Family Medicine at the UM Medical School will present a seminar, with Q&A, on "Of Moms and Microbes: Pregnancy and the Microbiome".

ZOOM link:
https://umich.zoom.us/j/97328685723

]]>
Lecture / Discussion Thu, 29 Oct 2020 13:13:13 -0400 2020-11-10T12:00:00-05:00 2020-11-10T12:50:00-05:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Environmental Research Seminar
Funded Summer Research! (November 10, 2020 4:00pm) https://events.umich.edu/event/78017 78017-19955538@events.umich.edu Event Begins: Tuesday, November 10, 2020 4:00pm
Location: Off Campus Location
Organized By: Office of National Scholarships & Fellowships (ONSF)

REGISTER: https://myumi.ch/bvnN2

Attend this session to explore fully-funded summer research programs available to U-M undergraduates! Examples include the Amgen Scholars Program, NSF Research Experiences for Undergraduates, DAAD Research Internships in Science & Engineering, and more!

Learn more: https://lsa.umich.edu/onsf/summer-programs.html

]]>
Livestream / Virtual Thu, 01 Oct 2020 09:07:18 -0400 2020-11-10T16:00:00-05:00 2020-11-10T17:00:00-05:00 Off Campus Location Office of National Scholarships & Fellowships (ONSF) Livestream / Virtual Microscope
Fusing Computer Vision And Space Weather Modeling (November 11, 2020 10:00am) https://events.umich.edu/event/79214 79214-20231455@events.umich.edu Event Begins: Wednesday, November 11, 2020 10:00am
Location: Off Campus Location
Organized By: Michigan Institute for Data Science

Space weather has impacts on Earth ranging from rare, immensely disruptive events (e.g., electrical blackouts caused by solar flares and coronal mass ejections) to more frequent impacts (e.g., satellite GPS interference from fluctuations in the Earth’s ionosphere caused by rapid variations in the solar extreme UV emission). Earth-impacting events are driven by changes in the Sun’s magnetic field; we now have myriad instruments capturing petabytes worth of images of the Sun at a variety of wavelengths, resolutions, and vantage points. These data present opportunities for learning-based computer vision since the massive, well-calibrated image archive is often accompanied by physical models. This talk will describe some of the work that we have been doing to start integrating computer vision and space physics by learning mappings from one image or representation of the Sun to another. I will center the talk on a new system we have developed that emulates parts of the data processing pipeline of the Solar Dynamics Observatory’s Helioseismic and Magnetic Imager (SDO/HMI). This pipeline produces data products that help study and serve as boundary conditions for solar models of the energetic events alluded to above. Our deep-learning-based system emulates a key component hundreds of times faster than the current method, potentially opening doors to new applications in near-real-time space weather modeling. In keeping with the goals of the symposium, however, I will focus on some of the benefits close collaboration has enabled in terms of understanding how to frame the problem, measure success of the model, and even set up the deep network.

]]>
Presentation Thu, 05 Nov 2020 10:27:08 -0500 2020-11-11T10:00:00-05:00 2020-11-11T10:20:00-05:00 Off Campus Location Michigan Institute for Data Science Presentation David Fouhey
Decoding the Environment of Most Energetic Sources in the Universe (November 11, 2020 10:20am) https://events.umich.edu/event/79215 79215-20231456@events.umich.edu Event Begins: Wednesday, November 11, 2020 10:20am
Location: Off Campus Location
Organized By: Michigan Institute for Data Science

Astrophysics has always been at the forefront of data analysis. It has led to advancements in image processing and numerical simulations. The coming decade is bringing qualitatively new and larger datasets than ever before. The next generation of observational facilities will produce an explosion in the quantity and quality of data for the most distant sources, such as the first galaxies and first quasars. Quasars are the most energetic objects in the universe, reaching luminosity up to 10^14 that of the Sun. Their emission is powered by giant black holes that convert matter into energy according to the famous Einstein’s equation E = mc^2. The largest progress will occur in quasar spectroscopy. Detailed measurements of spectrum of quasar light, as it is being emitted near the central black hole and partially absorbed by clouds of gas on the way to the observer on Earth, allows for a particularly powerful probe of quasar environment. Because spectra of different chemical elements are unique, spectroscopy allows to study not only the overall properties of matter such as density and temperature, but also the detailed chemical composition of the intervening matter. However, the interpretation of these spectra is made very challenging by the many sources contributing to the absorption of light. In order to take a full advantage of this new window into the nature of supermassive black holes we need detailed theoretical understanding of the origin of quasar spectral features. In a MIDAS PODS project we are applying machine learning to model and extract such features. We are training the models using data from the state-of-the-art numerical simulations of the early universe. This approach is fundamentally different from traditional astronomical data analysis. We have only started learning what information can be extracted and still looking for a new framework to interpret these data.

]]>
Performance Thu, 05 Nov 2020 10:31:24 -0500 2020-11-11T10:20:00-05:00 2020-11-11T10:40:00-05:00 Off Campus Location Michigan Institute for Data Science Performance Oleg Gnedin
Saturday Morning Physics VIRTUAL Event | The Light Fantastic (November 14, 2020 10:30am) https://events.umich.edu/event/77282 77282-19830135@events.umich.edu Event Begins: Saturday, November 14, 2020 10:30am
Location: Off Campus Location
Organized By: Saturday Morning Physics

Professor Alec Thomas will give a pre-recorded lecture with a "live" Q&A after the talk.

Youtube Event Link: https://www.youtube.com/watch?v=OGJg-eJF61c (Link will be active at 10:30 am on 11/14/20.) See saturdaymorningphysics.org for more details.

Since the invention of Chirped Pulse Amplification (Strickland and Mourou, Physics Nobel 2018), lasers have become increasingly powerful by squeezing energy into inconceivably short pulses. The pulses of intense light produced by these lasers, such as the new ZEUS facility being constructed at U-M, can generate precision beams of high energy particles for new technologies, produce the conditions of extreme astrophysical environments in the laboratory and create matter from (almost) nothing.

]]>
Workshop / Seminar Tue, 22 Sep 2020 16:09:15 -0400 2020-11-14T10:30:00-05:00 2020-11-14T11:30:00-05:00 Off Campus Location Saturday Morning Physics Workshop / Seminar Saturday Morning Physics Logo
Complex Systems Seminar Special Event | Searching for the densest network that does not always synchronize (November 17, 2020 2:30pm) https://events.umich.edu/event/78499 78499-20052321@events.umich.edu Event Begins: Tuesday, November 17, 2020 2:30pm
Location: Off Campus Location
Organized By: The Center for the Study of Complex Systems

PLEASE NOTE THE START TIME OF 2:30 PM!

ALSO NOTE, THIS SEMINAR WILL BE RECORDED.

SEMINAR LINK: myumi.ch/v2ZYv

Abstract: Consider a network of identical phase oscillators with sinusoidal coupling. How likely are the oscillators to globally synchronize, starting from random initial phases? One expects dense networks to have a strong tendency to synchronize and the basin of attraction for the synchronous state to be the whole phase space (except for a set of measure zero). But, how dense is dense enough? In this (hopefully) entertaining Zoom talk, we use techniques from nonlinear dynamics, numerical linear algebra, and computational algebraic geometry to derive the densest known networks that do *not* synchronize and the sparsest networks that do. This is joint work with Alex Townsend and Mike Stillman.

___

Dr. Strogatz - Jacob Gould Schurman Professor of Applied Mathematics at Cornell University - is the author of several international bestsellers about math, including "Infinite Powers" and "The Joy of x" - the latter, the title of an eponymous column in the New York Times and a new podcast series for Quanta Magazine.

With a vast body of work he is particularly well known for his publications on the small-world effect; understanding how thousands of fireflies flash in synchrony; why London's Millenium Bridge became unstable in 2000 just two days after it opened; and his mathematical model of
romance -- the "Romeo and Juliet" model.

]]>
Livestream / Virtual Mon, 16 Nov 2020 11:06:17 -0500 2020-11-17T14:30:00-05:00 2020-11-17T16:00:00-05:00 Off Campus Location The Center for the Study of Complex Systems Livestream / Virtual Steven Strogatz
Where Do We Go From Here: Body Politics & Movement Towards Racial Empowerment (November 19, 2020 12:00pm) https://events.umich.edu/event/79333 79333-20272796@events.umich.edu Event Begins: Thursday, November 19, 2020 12:00pm
Location: Off Campus Location
Organized By: School of Kinesiology

A virtual panel discussion sponsored by the University of Michigan Health Sciences units, hosted by the School of Kinesiology, and featuring:

Vanessa Barrow, DPM
Podiatrist & Owner, Sole Aesthetic, LLC
Specialization: Aesthetic and regenerative medicine of the foot and ankle

Neha Gothe, PhD
Assistant Professor of Kinesiology & Community Health, University of Illinois at Urbana-Champaign
Research: Bio-psycho-social health benefits of physical activity across the lifespan; yoga as a means to improve health and quality of life

Samuel R. Hodge, PhD
Professor of Kinesiology, Ohio State University
Research: Intersection of diversity, disability, and social justice in education and sport

NiCole R. Keith, PhD, FACSM
Professor of Kinesiology & Associate Dean, Indiana University School of Health & Human Sciences
President, American College of Sports Medicine
Research: Community-based participatory research, physical activity, and health equity

]]>
Lecture / Discussion Tue, 10 Nov 2020 17:05:27 -0500 2020-11-19T12:00:00-05:00 2020-11-19T13:00:00-05:00 Off Campus Location School of Kinesiology Lecture / Discussion University of Michigan Health Sciences present Where Do We Go From Here: Body Politics and Movement Towards Racial Empowerment
Science Success Series | Medical School Inside Story (November 30, 2020 5:00pm) https://events.umich.edu/event/76332 76332-19687524@events.umich.edu Event Begins: Monday, November 30, 2020 5:00pm
Location: Off Campus Location
Organized By: Science Learning Center

Do you have questions about medical school admissions? Get your answers straight from the inside! U-M Medical School Admissions Director Carol Teener will demystify medical school applications, expectations, and reviews in her presentation.

Register on Sessions: https://sessions.studentlife.umich.edu/track/event/session/29208

Email ScienceSuccessSeries@umich.edu with any questions.

]]>
Workshop / Seminar Fri, 28 Aug 2020 17:14:02 -0400 2020-11-30T17:00:00-05:00 2020-11-30T18:00:00-05:00 Off Campus Location Science Learning Center Workshop / Seminar
CSCS Seminar | Developing a systematic approach to modulate the emergence of consciousness from pharmacologically-and pathologically induced unconsciousness (December 1, 2020 11:30am) https://events.umich.edu/event/76220 76220-19677552@events.umich.edu Event Begins: Tuesday, December 1, 2020 11:30am
Location: Off Campus Location
Organized By: The Center for the Study of Complex Systems

ZOOM MEETING LINK: myumi.ch/v2ZYv

Re-scheduled from earlier this fall.

ABSTRACT:
Why is it so difficult to develop a systematic approach to modulate the recovery of consciousness from pharmacologically and pathologically induced unconsciousness? Three things are required to develop a systematic approach; a reliable neural activity that corresponds to consciousness, a reliable brain stimulation to induce the target neural activity, and a mechanism to guarantee the induced neural activity results in consciousness. However, no single neural activity or a mechanism has been identified yet as a neural correlate of consciousness, suggesting that consciousness might emerge through complex interactions of spatially and temporally distributed brain functions. Accumulating evidence from computational model and empirical studies suggest that brain criticality – a balanced state between order and disorder, stability and instability, incoherent and synchronized connectivity at a global network level, is a necessary condition for the emergence of consciousness. Thus, in our research project, we hypothesized that with modulating brain network criticality, we may be able to control the state transition during the loss and recovery of consciousness in general anesthesia and coma. In this talk, I will introduce our current project that aims to develop a systematic method to precisely evaluate a brain state in altered states of consciousness and to control the emergence from unconsciousness, which is based on highly advanced methods in physics, network science, and neurobiology of consciousness.

Please join us 15 minutes before and after the seminar for a social coffee hangout. Put your speakers and video on and say hi to old friends or go to the 'lounge' and chat with an acquaintance

]]>
Livestream / Virtual Mon, 23 Nov 2020 16:33:23 -0500 2020-12-01T11:30:00-05:00 2020-12-01T13:00:00-05:00 Off Campus Location The Center for the Study of Complex Systems Livestream / Virtual Photo of UnCheol Lee
Udall Scholarships (December 1, 2020 4:00pm) https://events.umich.edu/event/78020 78020-19955546@events.umich.edu Event Begins: Tuesday, December 1, 2020 4:00pm
Location: Off Campus Location
Organized By: Office of National Scholarships & Fellowships (ONSF)

REGISTER: https://myumi.ch/bvnN2

The Udall Foundation awards $5,000 scholarships to college sophomores and juniors and the opportunity to attend a 4-day orientation in Tucson, AZ and to gain access to the Udall Alumni Network.

The Ernest F. Hollings Scholarship provides support for approximately 125 full-time undergraduate students per year studying in NOAA mission fields. Scholarship recipients receive two years of academic support (up to $9,500/year) and a 10-week paid summer internship at a NOAA partner facility.

Learn more: https://lsa.umich.edu/onsf/scholarships/united-states/udall-scholarship.html

]]>
Livestream / Virtual Thu, 01 Oct 2020 09:23:59 -0400 2020-12-01T16:00:00-05:00 2020-12-01T17:00:00-05:00 Off Campus Location Office of National Scholarships & Fellowships (ONSF) Livestream / Virtual Van driving through Arizona
Meet a Scientist (December 5, 2020 10:00am) https://events.umich.edu/event/79458 79458-20333655@events.umich.edu Event Begins: Saturday, December 5, 2020 10:00am
Location: Off Campus Location
Organized By: Museum of Natural History

This virtual Zoom event is intended to be conversational with time built in for questions and discussion. From astronomy to zoology, you can choose the topics most interesting to you and/or your family.

You can explore up to 6 topics of most interest to you and/or your family by choosing from various Zoom links. (Links will be available the week of the event. )

Target audiences: families with tweens and teens, adults

Presentations include:

-The circuits of sleep
-Attack incoming! How neurons brace themselves for injury
-How to measure drinking water quality and public perception
-Using stem cells for studying and treating brain diseases
-Eye understand: tools for studying baby psychology
-What are cannabinoids and why should I care? An ongoing exploration of neuropharmacology
-Cells need friends too: how do cells stick together?
-Who does carbon fixation?
-Uncovering the mystery of surface chemistry
-Microbes: good, bad, or in-between?
-Looking inside the brain: designing methods to discover the neuronal circuits underlying behaviors

Scientists are part of the University of Michigan Museum of Natural History's Science Communication Fellows program, aimed at bringing together researchers and the general public. This event is a virtual adaptation of the museum’s in-person Scientist Spotlight events.

Suggested donation $5

]]>
Livestream / Virtual Wed, 18 Nov 2020 07:29:19 -0500 2020-12-05T10:00:00-05:00 2020-12-05T12:00:00-05:00 Off Campus Location Museum of Natural History Livestream / Virtual Meet a Scientist Virtual Event
RNA Seminar featuring: John Mattick, University of New South Wales, Sydney, Australia (December 7, 2020 5:00pm) https://events.umich.edu/event/75816 75816-19608031@events.umich.edu Event Begins: Monday, December 7, 2020 5:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_fCIiMkveTdq3D9-PKFLm6Q

ABSTRACT: The genomic programming of the development of complex organisms appears to have been misunderstood. The human genome contains just ~20,000 protein-coding genes, similar in number and with largely orthologous functions as those in other animals, including simple nematodes with only 1,000 somatic cells. By contrast, the extent of non-protein-coding DNA increases with increasing developmental complexity, reaching 98.8% in humans. Moreover, it is now clear that the majority of the genome is not junk but is differentially and dynamically transcribed to produce not only mRNAs but also tens if not hundreds of thousands of short and long non-protein-coding RNAs that show specific expression patterns and subcellular locations. Many of these noncoding RNAs have evolved rapidly under positive selection for adaptive radiation, and many have been shown to have important roles in development, brain function, cancer and other diseases. They function at many different levels of gene expression and cell biology, including translational control, formation of subcellular (phase-separated) domains, and guidance of the epigenetic processes and chromatin dynamics that underpin development, brain function and physiological adaptation, with plasticity enabled by RNA editing, RNA modification and retrotransposon mobilization. These discoveries mean that the assumption that combinatorial control by transcription factors and other regulatory proteins is sufficient to account for human ontogeny is incorrect, as are the circular assumptions about the neutral evolution of the genome. The challenge now is to determine the structure-function relationships of these RNAs and their mechanisms of action, as well as their place in the decisional hierarchies that control human development, physiology, learning and susceptibility to disorders.

]]>
Lecture / Discussion Tue, 03 Nov 2020 16:51:46 -0500 2020-12-07T17:00:00-05:00 2020-12-07T18:00:00-05:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion photo
Complex Systems Presents: A Nobel Symposium (December 10, 2020 1:10pm) https://events.umich.edu/event/79125 79125-20209862@events.umich.edu Event Begins: Thursday, December 10, 2020 1:10pm
Location: Off Campus Location
Organized By: The Center for the Study of Complex Systems

VIRTUAL SYMPOSIUM LINK: myumi.ch/v2ZYv

Registration not required. Free and open to the public. This virtual event features UM faculty experts in each of the six prize fields. Each will present for 25 minutes and take questions for 10 minutes

1:10 - 1:15 Welcome remarks Charlie Doering CSCS Director

1:15 - 1:50 CHEMISTRY | Nils Walter Chemistry, Biophysics and Biological Chemistry LSA and Medical School

1:50 - 2:25 MEDICINE OR PHYSIOLOGY | Katherine Spindler Microbiology and Immunology Medical School

2:25 - 3:00 PHYSICS | Lydia Bieri Mathematics and Doug Richstone  Astronomy LSA

3:00 - 3:35 ECONOMICS | Tilman Börgers Economics

3:35 - 4:10 LITERATURE | Linda Gregerson Literature LSA

4:10 - 4:45 PEACE | Susan Waltz Public Policy, Gerald R Ford School of Public Policy

Information about the 2020 prizes and our speakers:

*Chemistry:*
The Nobel Prize in Chemistry 2020 was awarded jointly to Emmanuelle Charpentier and Jennifer A. Doudna "for the development of a method for genome editing."

Speaker: *Nils Walter*, Francis S Collins Collegiate Professor of Chemistry, Biophysics and Biological Chemistry – College of Literature, Science, and the Arts and Medical School

*Physiology or Medicine:*
The 2020 Nobel Prize in Physiology or Medicine is awarded jointly to *Harvey J. Alter, Michael Houghton* and *Charles M. Rice* “for the discovery of Hepatitis C virus”. Thanks to their discovery, highly sensitive blood tests for the virus are now available and these have essentially eliminated post-transfusion hepatitis in many parts of the world, greatly improving global health.

Speaker: *Katherine Spindler,* Professor of Microbiology and Immunology – Michigan Medicine

*Physics:*
The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Physics 2020 with one half to *Roger Penrose* “for the discovery that black hole formation is a robust prediction of the general theory of relativity" and the other half jointly to *Reinhard Genzel* and *Andrea Ghez* "for the discovery of a supermassive compact object at the centre of our galaxy".

Speaker: *Lydia Bieri*, Associate Professor of Mathematics and Director, Michigan Center for Applied & Interdisciplinary Mathematics and *Doug Richstone*, Lawrence H Aller Collegiate Professor of Astronomy – College of Literature, Science, and the Arts

*Economics:*
This year’s Laureates, *Paul Milgrom* UM-LSA Mathematics Alum! and *Robert Wilson*, have studied how auctions work. They have also used their insights to design new auction formats for goods and services that are difficult to sell in a traditional way, such as radio frequencies. Their discoveries have benefitted sellers, buyers and taxpayers around the world.

Speaker:* Tilman Börgers*, Samuel Zell Professor of the Economics of Risk – College of Literature, Science, and the Arts

*Literature:*
The Nobel Prize in Literature for 2020 is awarded to the American poet Louise Glück “for her unmistakable poetic voice that with austere beauty makes individual existence universal”.

Speaker: *Linda Gregerson*, Caroline Walker Bynum Distinguished University Professor of English Language and Literature – College of Literature, Science, and the Arts

*Peace:*
'Combatting the threat of hunger' The Norwegian Nobel Committee has decided to award the Nobel Peace Prize for 2020 to the *World Food Programme (WFP)*. The World Food Programme is the world’s largest humanitarian organization addressing hunger and promoting food security. In 2019, the WFP provided assistance to close to 100 million people in 88 countries who are victims of acute food insecurity and hunger.

The World Food Programme is the food-assistance branch of the United Nations and the world's largest humanitarian organization focused on hunger and food security. Founded in 1961, it is headquartered in Rome and has offices in 80 countries

Speaker: *Susan Waltz*, Professor of Public Policy, Gerald R Ford School of Public Policy

Read more about the details of each of the 2020 prizes here: https://www.nobelprize.org/prizes/

]]>
Livestream / Virtual Mon, 07 Dec 2020 16:19:38 -0500 2020-12-10T13:10:00-05:00 2020-12-10T16:45:00-05:00 Off Campus Location The Center for the Study of Complex Systems Livestream / Virtual Nobel Symposium Poster
RNA Seminar featuring: Narry Kim, Seoul National University (December 14, 2020 4:00pm) https://events.umich.edu/event/75818 75818-19608034@events.umich.edu Event Begins: Monday, December 14, 2020 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

ZOOM REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_c9BFJM9dRGKn1WFF4L_wLg

ABSTRACT: Viruses rely heavily on RNA binding proteins for their success as pathogens. In this presentation, I will first talk about RNA tail modification which impacts viral and cellular gene expression. We found that TENT4 enzymes extend poly(A) tail of mRNAs with ‘mixed tails’ to delay deadenylation and stabilize the RNAs. Hepatitis B virus and human cytomegalovirus hijack this mechanism to efficiently stabilize their own RNAs. In the later part of my presentation, I will discuss our recent work on SARS-CoV-2. To delineate the viral transcriptomic architecture and provide a high-resolution map of SARS-CoV-2, we performed deep sequencing of infected cells. Our data define the canonical transcripts and noncanonical transcripts encoding unknown ORFs. More recently, we have also performed proteomic analyses of the SARS-CoV-2 ribonucleoprotein complex. We identify many proteins that directly interact with viral RNAs and modulate viral growth. Functional investigation of the viral transcripts and host proteins discovered in this study will open new directions to the research efforts to elucidate the life cycle and pathogenicity of SARS-CoV-2.

]]>
Lecture / Discussion Wed, 02 Dec 2020 12:55:41 -0500 2020-12-14T16:00:00-05:00 2020-12-14T17:00:00-05:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Narry Kim, Seoul National University
MIDAS & Owkin Federated Learning in Biomedical Research Workshop (January 14, 2021 10:00am) https://events.umich.edu/event/80139 80139-20566722@events.umich.edu Event Begins: Thursday, January 14, 2021 10:00am
Location: Off Campus Location
Organized By: Michigan Institute for Data Science

Objective: Cultivating research collaboration, joint grants and connecting the UM researchers to the right organisations. Supports Owkin expansion of our presence in North America and facilitates collaborations with PIs at UM. A great introduction to what Owkin does to UM.

Introduction Owkin & Scientific Overview of the Sessions — Patrick Sin-Chan, Partnerships Manager – Owkin
Session 1: Methodology and Data Science
Learning From Others Without Sacrificing Privacy: Application of Federated Machine Learning to Mobile Health Data
Presenter: Ambuj Tewari, Associate Professor, Statistics
Privacy Preserving Federated Learning Platform: from Design to Deployment in Real World Use Cases
Presenter: Camille Marini
Accelerating Machine Learning with Multi-Armed Bandit
Barzan Mozafari, Associate Professor, Computer Science and Engineering
Siloed Federated Learning for Multi-Centric Histopathology Datasets
Presenter: Mathieu Andreux
20 mins Panel Discussion (MIDAS Moderator- Kayvan Najarian, Professor, Computational Medicine and Bioinformatics)
Session 2: Biotech/medical
Covid-19 Severity Analysis with CT Scans and Machine Learning
Presenter: Simon Jégou
Linking Single-cell Molecular States with Phenotypes Using Machine Learning
Presenter: Josh Welch, Assistant Professor, Computational Medicine and Bioinformatics
HE2RNA: a Deep Learning Model to Predict RNA-Seq Expression of Tumors from Whole Slide Images
Presenter: Alberto Romagnoni
Using Large-scale Pharmacogenomic Databases to Predict Drug Effectiveness
Presenter: Johann Gagnon-Bartsch, Assistant Professor, Statistics
20 mins Panel discussion (Owkin Moderator: Patrick Sin-Chan)

]]>
Workshop / Seminar Thu, 17 Dec 2020 19:36:31 -0500 2021-01-14T10:00:00-05:00 2021-01-14T14:30:00-05:00 Off Campus Location Michigan Institute for Data Science Workshop / Seminar Okwin
U-M Health Sciences 2021 MLK Keynote (January 18, 2021 12:00pm) https://events.umich.edu/event/79757 79757-20484063@events.umich.edu Event Begins: Monday, January 18, 2021 12:00pm
Location: Off Campus Location
Organized By: School of Kinesiology

Bodies represent the sites of socially constructed differences and power relations. As such, the personal is political, and bodies are subject to political interpretations. Body politics based on racial (and/or ethnic) ascriptions (along with other intersecting elements such as sex, gender, sexuality, age, social class, ability, etc.) have adversely affected the overall health and wellness of bodies of Color in general, and Black bodies in particular - impacting their abilities, opportunities, access (inclusion/exclusion), care/treatment, and the overall nature of their lived experiences. Consequently, racialed body politics have contributed to an array of health disparities being more pronounced in communities of Color. However, movement offers a variety of health benefits and is therefore, a source of empowerment for racially politicized bodies.

This event will feature a keynote presentation by Dr. Monique Butler, U-M Kinesiology alumna and Chief Medical Officer for HCA Healthcare North Florida Division. She will address the theme "Where Do We Go From Here: Body Politics and Movement Towards Racial Empowerment."

This event is sponsored by the U-M Health Sciences units and hosted by the School of Kinesiology.

]]>
Lecture / Discussion Tue, 05 Jan 2021 16:27:06 -0500 2021-01-18T12:00:00-05:00 2021-01-18T13:30:00-05:00 Off Campus Location School of Kinesiology Lecture / Discussion U-M Health Sciences 2021 MLK Keynote - Where Do We Go From Here: Body Politics and Movement Towards Racial Empowerment - with Dr. Monique Butler, MD
RNA Seminar featuring: Elena Conti, Max Planck Institute of Biochemistry (January 25, 2021 9:00am) https://events.umich.edu/event/75826 75826-19613920@events.umich.edu Event Begins: Monday, January 25, 2021 9:00am
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

KEYWORDS: molecular mechanisms, RNA, ribosome, biochemistry, cryo-EM, X-ray crystallography

ABSTRACT: All RNAs in eukaryotic cells are eventually degraded. The RNA exosome is a conserved macromolecular machine that degrades a vast number and variety of RNAs. Exosome-mediated RNA degradation leads to the complete elimination of nuclear and cytoplasmic transcripts in turnover and quality control pathways, and to the partial trimming of RNA precursors in nuclear processing pathways. How the exosome combines specificity and versatility to either eliminate or process RNAs has been a long-standing question.

ZOOM REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_IjnWw1UcRkW8zcDeuAM2tQ

]]>
Lecture / Discussion Mon, 04 Jan 2021 10:08:44 -0500 2021-01-25T09:00:00-05:00 2021-01-25T10:00:00-05:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Elena Conti, Max Planck Institute of Biochemistry
Science Success Series | Growth and Grit: Developing a Mindset for Success (January 27, 2021 4:00pm) https://events.umich.edu/event/80591 80591-20759748@events.umich.edu Event Begins: Wednesday, January 27, 2021 4:00pm
Location: Off Campus Location
Organized By: Science Learning Center

What if your ability to succeed in your classes was determined in part before you even stepped into the classroom? What is the one quality you need to overcome adversity academically and in life? This workshop will detail the research of Dr. Carol Dweck and her groundbreaking work on the concept of mindset. Students will learn how to abandon a debilitating fixed mindset in favor of a growth mindset, leading to success in areas they once considered too difficult. The workshop will also introduce students to the research of Dr. Angela Duckworth, and how a growth mindset can lead to the development of grit, an essential characteristic to overcoming our fear of failure.

Register at: myumi.ch/DEDPD

]]>
Workshop / Seminar Mon, 11 Jan 2021 11:23:23 -0500 2021-01-27T16:00:00-05:00 2021-01-27T17:30:00-05:00 Off Campus Location Science Learning Center Workshop / Seminar growth and grit
Special Physics Department MLK Colloquium | Equity in Science: Representation, Culture, and the Dynamics of Change in Graduate Education (January 27, 2021 4:00pm) https://events.umich.edu/event/79793 79793-20499783@events.umich.edu Event Begins: Wednesday, January 27, 2021 4:00pm
Location: Off Campus Location
Organized By: Department Colloquia

STEM disciplines are believed to be founded on the idea of meritocracy; recognition earned by the value of the data, which is objective. Such disciplinary cultures resist concerns about implicit or structural biases, and yet, year after year, scientists observe persistent gender and racial inequalities in their labs, departments, and programs. In this colloquium, Julie Posselt makes the case that understanding field-specific cultures is a crucial step for bringing about real change and that we can learn as much from quantum as classical dynamics about the dynamics of scientific organizations. She will share research that compares equity, diversity, and inclusion efforts in astronomy and physics, and the subtle ways that exclusion and power operate in scientific organizations and, sometimes, within change efforts themselves.

Julie Posselt's bio:
Dr. Julie Posselt received her Ph.D. from the University of Michigan School of Education and is currently an Associate Professor of higher education in the USC Rossier School of Education. Specializing in graduate education and STEM fields, and elite undergraduate institutions, her research examines institutionalized inequities in higher education and organizational efforts aimed at reducing inequalities and encouraging diversity. She has also written a book, Inside Graduate Admissions: Merit, Diversity, and Faculty Gatekeeping (2016, Harvard University Press), based on an award-winning study of faculty judgment in ten highly ranked doctoral programs in three universities. This work has led to a partnership with USC, APS, and the Council of Graduate Schools that focuses on re-examining how we evaluate students and scholars for key academic opportunities.

]]>
Workshop / Seminar Fri, 27 May 2022 16:14:55 -0400 2021-01-27T16:00:00-05:00 2021-01-27T17:00:00-05:00 Off Campus Location Department Colloquia Workshop / Seminar Photo of Julie Posselt
A human-environment systems approach to prioritizing COVID-19 vaccination (January 28, 2021 11:30am) https://events.umich.edu/event/80709 80709-20777524@events.umich.edu Event Begins: Thursday, January 28, 2021 11:30am
Location: Off Campus Location
Organized By: The Center for the Study of Complex Systems

SEMINAR LINK: https://umich.zoom.us/s/96616169868

Madhur Anand - School of Environmental Sciences
Chris Bauch - Department of Math, Applied Math

Join us THURSDAY January 28 at 11:30 am for our first VIRTUAL SEMINAR of 2021.

Abstract:
During the COVID-19 pandemic, authorities must decide which groups to prioritize for vaccination in an evolving landscape where infection dynamics and population mitigating behavior are mutually connected in a feedback loop (i.e., human-environment interactions). Moreover, if we discover that vaccines prevent not only disease but also transmission, authorities must factor vaccine indirect protection (vaccine-generated herd immunity) into their considerations, which sometimes suggest a strategy of targeting groups that cause the most transmission. In this talk we will use a mathematical model to address the question: which age group should be prioritized for COVID-19 vaccination in order to prevent the most deaths? We developed an age-structured human-environment mathematical model for Ontario, Canada, where evolutionary game theory describes how population adherence to non-pharmaceutical interventions (NPIs) responds to case incidence. Schools and workplaces are also closed and re-opened based on reported cases. We compared strategies of vaccinating 60+ year-olds first; <20 year-olds first; uniformly by age; and a novel contact-based strategy. The last three strategies interrupt transmission while the first targets a vulnerable group. The model shows realistic dynamics whereby case notifications, NPI adherence, and lockdown undergo successive waves that interact with timing of the vaccine program to determine the relative effectiveness of the four strategies. We identify a parameter regime where transmission-interrupting strategies are more effective in preventing deaths than prioritizing older age groups. We conclude that using SARS-CoV-2 vaccines to interrupt transmission may prevent more deaths than prioritizing vulnerable age groups, depending on the time course of the pandemic in a given population.

]]>
Livestream / Virtual Thu, 28 Jan 2021 11:30:21 -0500 2021-01-28T11:30:00-05:00 2021-01-28T13:00:00-05:00 Off Campus Location The Center for the Study of Complex Systems Livestream / Virtual Anand, Bauch
Our National Marine Sanctuaries, Protecting America's Underwater Treasures: (January 29, 2021 12:00pm) https://events.umich.edu/event/80998 80998-20830797@events.umich.edu Event Begins: Friday, January 29, 2021 12:00pm
Location: Off Campus Location
Organized By: Museum Studies Program

Stephanie Gandulla, Maritime Archaeologist and Research Coordinator at the Thunder Bay National Marine Sanctuary, will explore some of the nation’s best-preserved shipwrecks in the Great lakes and describe how the Sanctuary was designated and became part of the Michigan History Center’s statewide system of museums and historic sites.

Register via Zoom here: https://umich.zoom.us/webinar/register/WN_2EaxIke3RficoM9yHzHk2A

Additional details here: https://myumi.ch/WwmWZ

]]>
Livestream / Virtual Wed, 20 Jan 2021 13:39:56 -0500 2021-01-29T12:00:00-05:00 2021-01-29T13:00:00-05:00 Off Campus Location Museum Studies Program Livestream / Virtual Thunder Bay National Marine Sanctuary
RNA Seminar featuring: Jeff Twiss, MD, PhD, SmartState Chair in Childhood Neurotherapeutics, Professor of Biological Sciences, University of South Carolina (February 1, 2021 4:00pm) https://events.umich.edu/event/75813 75813-19608028@events.umich.edu Event Begins: Monday, February 1, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_Rss4i-7WTwyf8m8ogCPXEQ

Abstract: Neurons are extremely polarized cells with axonal and dendritic processes extending 100 to 1000 fold longer or more than the cell body diameter. Our lab has been interested in how axons grow to such great distances and how they respond to injury. mRNAs are transported into axons, with their localized translation providing the axon with autonomy to respond to different stimuli by modifying their local proteome. Transport, translation, and stability of axonal mRNAs is driven by interactions with RNA binding proteins and different signaling cascades. I will focus on recent work that gives insight into how specificity of these mechanisms is driven for different cohorts of axonal mRNAs.

Keywords - Neuron, Axon, RNA transport, Translational regulation

]]>
Lecture / Discussion Fri, 15 Jan 2021 14:13:00 -0500 2021-02-01T16:00:00-05:00 2021-02-01T17:00:00-05:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Jeff Twiss, University of South Carolina
Science Success Series | Make It Stick: Research-Based Learning Strategies You Need to Know (February 3, 2021 4:00pm) https://events.umich.edu/event/80585 80585-20759746@events.umich.edu Event Begins: Wednesday, February 3, 2021 4:00pm
Location: Off Campus Location
Organized By: Science Learning Center

The study and learning strategies students often bring to college are often insufficient to help them succeed at the university level. Particularly in challenging STEM courses, students can't simply memorize or cram their way to a good grade. This workshop will focus on the popular learning strategies to avoid, as well as the top three strategies you don't know but are shown by research to be the most effective for long-term learning.

Register at: myumi.ch/885DK

]]>
Workshop / Seminar Mon, 11 Jan 2021 11:24:23 -0500 2021-02-03T16:00:00-05:00 2021-02-03T17:30:00-05:00 Off Campus Location Science Learning Center Workshop / Seminar make it stick
Community Action to Promote Healthy Environments: Research to Improve Air Quality & Health in Detroit (February 9, 2021 12:00pm) https://events.umich.edu/event/81709 81709-20943461@events.umich.edu Event Begins: Tuesday, February 9, 2021 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

With Amy Schulz (HBHE UM SPH), Stuart Batterman (EHS UM SPH), and Angela Reyes (Detroit Hispanic Development Corporation) speaking on "Community Action to Promote Healthy Environments: Research to Improve Air Quality & Health in Detroit".

ZOOM LINK: HTTPS://UMICH.ZOOM.US/J/96155698295

Organized by the Community Engagement Core & Integrated Health Sciences Core of M-LEEaD (Michigan Center on Lifestage Environmental Exposures and Disease)

]]>
Livestream / Virtual Wed, 03 Feb 2021 16:27:30 -0500 2021-02-09T12:00:00-05:00 2021-02-09T12:50:00-05:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Livestream / Virtual Feb 9 Air Quality & Health in Detroit
CSCS Seminar: Universal Biology in Adaptation and Evolution: Multilevel Consistency, Dimensional Reduction, and Fluctuation-Response Relationship (February 9, 2021 7:00pm) https://events.umich.edu/event/80714 80714-20777539@events.umich.edu Event Begins: Tuesday, February 9, 2021 7:00pm
Location: Off Campus Location
Organized By: The Center for the Study of Complex Systems

A special Happy Hour seminar - live from Tokyo Japan. Join us on Tuesday evening at 7:00 pm EST to hear from pre-eminent Complex Systems scientist Kunihiko Kaneko.

LOCAL U.S.A. MEETING LINK: myumi.ch/v2ZYv
FULL MEETING INVITE WITH INTERNATIONAL LINKS:
https://lsa.umich.edu/cscs/news-events/all-news/search-news/complete-seminar-join-invitation-for-complex-systems-seminar.html

Abstract:
A macroscopic theory for cellular states with steady-growth is presented, based on consistency between cellular growth and molecular replication, as well as robustness of phenotypes against perturbations. Adaptive changes in high-dimensional phenotypes are shown to be restricted within a low-dimensional slow manifold, from which a macroscopic law for cellular states is derived, as is confirmed by adaptation experiments of bacteria under stress. Next, the theory is extended to phenotypic evolution, leading to proportionality between phenotypic responses against genetic evolution and by environmental adaptation. Evolutionary relevance of slow modes in controlling high-dimensional phenotypes is discussed. Last, I will touch upon the origin of central dogma in molecular biology as symmetry breaking between function and information.

]]>
Livestream / Virtual Tue, 09 Feb 2021 15:03:58 -0500 2021-02-09T19:00:00-05:00 2021-02-09T20:30:00-05:00 Off Campus Location The Center for the Study of Complex Systems Livestream / Virtual Headshot of Kunihiko Kaneko
Innovations in Relating Real Life Exposures to Chemicals and Chemical Mixtures to Health Outcomes (February 12, 2021 1:00pm) https://events.umich.edu/event/79684 79684-20454248@events.umich.edu Event Begins: Friday, February 12, 2021 1:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Tentative Symposium Schedule

1:00-1:05 - Introduction
1:05-1:30 - Dr. Andreas Kortenkamp, Brunel University: “Male reproductive health – a bad cocktail of endocrine disruptors”
1:30-1:55 - Dr. Jodi Flaws, University of Illinois at Urbana-Champaign: “Applying real life phthalate mixtures from an Illinois pregnancy cohort to toxicological models”
1:55-2:20 - Dr. Laura Vandenberg, University of Massachusetts Amherst: “The mammary gland is a sensitive organ: lessons learned from fracking chemical mixtures”
2:00-2:55 - Dr. Paul Fowler, University of Aberdeen: “Exposure to the complex mixture of environmental chemicals found in human biosolids”
2:55-3:20 - Dr. Jyotsna Jagai, University of Illinois at Chicago: “Cumulative environmental quality and diabetes rates and control”
3:20-3.35 - Questions
3:35-4:00 - Panel Discussion, featuring: Dr. Jennifer McPartland, Environmental Defense Fund, Dr. Natalie Sampson, University of Michigan, Dr. Zorimar Rivera-Núñez, Rutgers University

]]>
Workshop / Seminar Mon, 11 Jan 2021 09:15:50 -0500 2021-02-12T13:00:00-05:00 2021-02-12T16:00:00-05:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Workshop / Seminar FLYER_20210212_Symposium
Research in the Liberal Arts (February 15, 2021 4:00pm) https://events.umich.edu/event/81272 81272-20879912@events.umich.edu Event Begins: Monday, February 15, 2021 4:00pm
Location: Off Campus Location
Organized By: The College of Literature, Science, and the Arts

A one-hour webinar for admitted students to learn more about the many opportunities to do research in the natural sciences, social sciences, and humanities. Learn more about the Undergraduate Research Opportunity Program (UROP), UM Biological Station, Kelsey Museum of Archeology, LSA Honors Program, Michigan Research and Discovery Scholars (MRADS), Women in Science and Engineering Residence Program (WISE-RP), M-Science, and more!

]]>
Livestream / Virtual Tue, 02 Feb 2021 15:53:55 -0500 2021-02-15T16:00:00-05:00 2021-02-15T17:00:00-05:00 Off Campus Location The College of Literature, Science, and the Arts Livestream / Virtual Explore the different research opportunities LSA has to offer!
RNA Seminar featuring: Karla Neugebauer, Yale University School of Medicine (February 15, 2021 4:00pm) https://events.umich.edu/event/78295 78295-20004839@events.umich.edu Event Begins: Monday, February 15, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

ZOOM REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_aZggyZ0yQcSPcJrsHloXjQ

ABSTRACT: My lab is interested in the coordination between transcription, RNA processing and nuclear organization that governs gene expression. We have established experimental systems in budding yeast, zebrafish embryos, and mammalian tissue culture cells to explore transcription and splicing regulation in a variety of biological contexts and with a diversity of tools, from imaging to genome-wide approaches. Our observations have provided novel insights into transcription and splicing mechanisms as well as principles of cellular organization that facilitate efficient gene expression. In this talk, I will be discussing rapid co-transcriptional splicing during erythropoiesis and how Cajal bodies assemble to ensure a steady supply of spliceosomal components.

]]>
Lecture / Discussion Tue, 02 Feb 2021 16:32:41 -0500 2021-02-15T16:00:00-05:00 2021-02-15T17:00:00-05:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Prof. Karla Neugebauer, Ph.D.
Complex Systems Seminar | Decolonizing Complexity: Bottom-up Traditions in Computational Futures (February 16, 2021 11:30am) https://events.umich.edu/event/81644 81644-20935530@events.umich.edu Event Begins: Tuesday, February 16, 2021 11:30am
Location: Off Campus Location
Organized By: The Center for the Study of Complex Systems

Join Link: https://umich.zoom.us/j/96616169868

Abstract: Indigenous cultures around the world developed an extraordinary repertoire of practices that embody many of the goals ultimately sought by complex systems researchers: egalitarian social relations, circular economies, ecological sustainability. Working with their modern descendents, we can develop collaborative practices that bring together “bottom-up” cultural traditions such as African fractals, Native American biocomplexity and restorative justice with contemporary computing technologies and frameworks.

]]>
Workshop / Seminar Tue, 16 Feb 2021 10:20:24 -0500 2021-02-16T11:30:00-05:00 2021-02-16T13:00:00-05:00 Off Campus Location The Center for the Study of Complex Systems Workshop / Seminar Professor Ron Eglash
RC Intros: Interested in learning more about the Residential College? (February 17, 2021 5:00pm) https://events.umich.edu/event/81758 81758-20951379@events.umich.edu Event Begins: Wednesday, February 17, 2021 5:00pm
Location: Off Campus Location
Organized By: Residential College

RC Intros: Interested in learning more about the Residential College?

Come here more from current RC students and ask your questions - everything from RC language experience to finding community at U-M!

Wednesday, February 17, 2021, 5-6pm
Register at myumi.ch/ovP9N

]]>
Reception / Open House Fri, 05 Feb 2021 14:44:35 -0500 2021-02-17T17:00:00-05:00 2021-02-17T18:00:00-05:00 Off Campus Location Residential College Reception / Open House RC Intros
Science Success Series | Medical School Student Panel Discussion (February 18, 2021 6:30pm) https://events.umich.edu/event/80634 80634-20769609@events.umich.edu Event Begins: Thursday, February 18, 2021 6:30pm
Location: Off Campus Location
Organized By: Science Learning Center

Here is your chance to hear about what life is like for several medical school students and residents. Learn about each of their paths to medicine, experiences in various medical schools, and things they wished they had known in college.

Panelists:

Jasmine D.Johnson, M.D., FACOG/Clinical Instructor & Fellow UNC Department of Obstetrics & Gynecology/ Division of Maternal-Fetal Medicine

Eric Poole. Rising M3, Michigan State University College of Human Medicine

Register at: myumi.ch/Wwm09

]]>
Workshop / Seminar Tue, 12 Jan 2021 12:14:31 -0500 2021-02-18T18:30:00-05:00 2021-02-18T19:30:00-05:00 Off Campus Location Science Learning Center Workshop / Seminar book and stethoscope
Saturday Morning Physics VIRTUAL Event | Weighing and Counting Giants in the Sky (February 20, 2021 10:30am) https://events.umich.edu/event/80680 80680-20775536@events.umich.edu Event Begins: Saturday, February 20, 2021 10:30am
Location: Off Campus Location
Organized By: Saturday Morning Physics

Maria Elidaiana da Silva Pereira will give a "live" lecture with a "live" Q&A after the talk.
Virtual Presentation Link: https://www.youtube.com/watch?v=9h8l_Pl9xLQ (Link will be active at 10:30 am on 02/20/21.)

Galaxy Clusters are the largest astronomical objects in the Universe. These cosmic giants are bound together by gravity and are formed by galaxies, hot gas, and mysterious dark matter. By counting them and measuring their masses, we can understand the content and evolution of the Universe. In this talk, I will present how we can use light for weighing galaxy clusters. I will also show how the Dark Energy Survey uses them to measure the quantity of dark matter and properties of the even more mysterious component, the dark energy.

]]>
Lecture / Discussion Thu, 18 Feb 2021 13:48:00 -0500 2021-02-20T10:30:00-05:00 2021-02-20T11:30:00-05:00 Off Campus Location Saturday Morning Physics Lecture / Discussion Photo of Maria Elidaiana da Silva Pereira
Science Success Series | Ace Your Courses: Metacognition is Key! (February 22, 2021 4:00pm) https://events.umich.edu/event/80592 80592-20759749@events.umich.edu Event Begins: Monday, February 22, 2021 4:00pm
Location: Off Campus Location
Organized By: Science Learning Center

Have you ever found yourself putting forth a great deal of effort into your courses, but not feeling like you are actually learning or are left unsatisfied with your grade? This workshop, based on the work of Dr. Saundra Yancy McGuire, will enable you to analyze your current learning strategies, understand exactly what changes you need to implement to earn an A in your courses, identify concrete strategies to use during the remainder of your semester, and become a more efficient learner.

Register at: myumi.ch/9o7zb

]]>
Workshop / Seminar Mon, 11 Jan 2021 11:32:51 -0500 2021-02-22T16:00:00-05:00 2021-02-22T17:30:00-05:00 Off Campus Location Science Learning Center Workshop / Seminar Teach Yourself How to Learn
Complex Systems Seminar: 'Low rattling: A predictive principle for self-organization in active collectives' (February 23, 2021 11:30am) https://events.umich.edu/event/80724 80724-20777541@events.umich.edu Event Begins: Tuesday, February 23, 2021 11:30am
Location: Off Campus Location
Organized By: The Center for the Study of Complex Systems

VIRTUAL SEMINAR LINK: https://umich.zoom.us/j/96616169868

ABSTRACT: In this work we suggest a mechanism for self-organization of active matter, which we believe may be quite general. This mechanism is similar in spirit to thermophoretic drift in colloidal suspensions, where particles gravitate to low-temperature regions. The difference is that here instead of suspended particles in a bath, we think of the dynamics of a complex system's state in its full high-dimensional configuration space. The temperature landscape is then replaced by what we call "Rattling landscape," which reflects how different system states respond to the driving forces. This way the system gravitates towards configurations that have special response properties to the external forces, giving the impression that it "adapts to its environment." As a proof of principle, we use our theory to predict and control the behavior of a simple robotic swarm.

]]>
Livestream / Virtual Thu, 18 Feb 2021 11:46:19 -0500 2021-02-23T11:30:00-05:00 2021-02-23T13:00:00-05:00 Off Campus Location The Center for the Study of Complex Systems Livestream / Virtual Pavel Chvykov
Residential College Zoom Chats for Prospective Students (February 26, 2021 4:00pm) https://events.umich.edu/event/82001 82001-21004766@events.umich.edu Event Begins: Friday, February 26, 2021 4:00pm
Location: Off Campus Location
Organized By: Residential College

Chat with current RC students in a casual setting and learn more about the RC student experience!

>> Friday, 2/26/2021, 4-5pm ET

>> Thursday, 3/11/2021, 3-4pm ET

>> Monday, 4/5/2021, 6-7pm ET

Register via email at visittherc@gmail.com

]]>
Social / Informal Gathering Thu, 11 Feb 2021 09:35:11 -0500 2021-02-26T16:00:00-05:00 2021-02-26T17:00:00-05:00 Off Campus Location Residential College Social / Informal Gathering RC Zoom Chats flier
CSCS Seminar: New data, models, and methods to guide SARS-CoV-2 vaccine design and vaccination programs that counter escape mutations (March 2, 2021 11:30am) https://events.umich.edu/event/82119 82119-21036721@events.umich.edu Event Begins: Tuesday, March 2, 2021 11:30am
Location: Off Campus Location
Organized By: The Center for the Study of Complex Systems

Join Link: myumi.ch/v2ZYv

ABSTRACT:
Before the emergence of escape mutants that now threaten pandemic control, we constructed and analyzed the first model integrating immune waning and escape mutations. In the model, escape mutants were not problematic until a year into the pandemic. After they emerged, vaccination could worsen the pandemic. We examined four patterns by which existing escape mutants could stimulate further escape mutations. These provide insights in how to pursue epitope (the part of an antigen recognized by the immune system) specific model analyses. The time is ripe for this advance. The pandemic has unveiled new high-throughput methods to characterize immunity at an epitope specific and B and T cell specific levels. We will present our model and discuss how it could integrate systems immunology and systems epidemiology.

]]>
Workshop / Seminar Mon, 01 Mar 2021 10:08:33 -0500 2021-03-02T11:30:00-05:00 2021-03-02T13:00:00-05:00 Off Campus Location The Center for the Study of Complex Systems Workshop / Seminar James Koopman and Carl Simon
RNA Seminar featuring: Melissa Moore, Moderna Therapeutics (March 3, 2021 4:00pm) https://events.umich.edu/event/81265 81265-20879904@events.umich.edu Event Begins: Wednesday, March 3, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

**Please register here for March 3rd seminar: https://umich.zoom.us/webinar/register/WN_l0kt_NjpRh-f33LJj7KGpA

Dr. Moore will address scientists and non-scientists, and will take live questions.

In her role as Chief Scientific Officer, Platform Research, Dr. Melissa Moore is responsible for leading mRNA biology, delivery and computation science research at Moderna. She joined Moderna in 2016 from the University of Massachusetts Medical School, where she served as Professor of Biochemistry & Molecular Pharmacology, Eleanor Eustis Farrington Chair in Cancer Research and a long-time Investigator at the Howard Hughes Medical Institute (HHMI). Dr. Moore was also a founding Co-Director of the RNA Therapeutics Institute (RTI) at UMassMed, and was instrumental in creating the Massachusetts Therapeutic and Entrepreneurship Realization initiative (MassTERi), a faculty-led program intended to facilitate the translation of UMMS discoveries into drugs, products, technologies and companies. Dr. Moore is an elected member of the National Academy of Sciences (2017) and a Fellow of the American Academy of Arts and Sciences (2019).

Dr. Moore holds a B.S. in Chemistry and Biology from the College of William and Mary, and a Ph.D. in Biological Chemistry from MIT, where she specialized in enzymology under Prof. Christopher T. Walsh. She began working on RNA metabolism during her postdoctoral training with Phillip A. Sharp at MIT. During her 23 years as a faculty member, first at Brandeis and then at UMassMed, her research encompassed a broad array of topics related to the roles of RNA and RNA-protein (RNP) complexes in gene expression, and touched on many human diseases including cancer, neurodegeneration, and preeclampsia.

]]>
Lecture / Discussion Wed, 10 Feb 2021 19:47:49 -0500 2021-03-03T16:00:00-05:00 2021-03-03T17:00:00-05:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Melissa Moore, Ph.D., Moderna Therapeutics
Saturday Morning Physics VIRTUAL Event | The Physics of Basketball (March 6, 2021 10:30am) https://events.umich.edu/event/82124 82124-21036718@events.umich.edu Event Begins: Saturday, March 6, 2021 10:30am
Location: Off Campus Location
Organized By: Saturday Morning Physics

Professor Chupp will give a pre-recorded lecture followed by a “live” Q&A
Virtual Presentation Link: https://www.youtube.com/watch?v=oBmpwVeuIpg

Basketball is one of the world's most popular sports played and enjoyed by fans of all ages. Spectacular plays seem to defy the laws of physics, but like everything, basketball is packed full of interesting phenomena. Physics Professor Tim Chupp and the Demolab will demonstrate and explain the science of key elements of the game in this lecture designed to entertain and deepen your enjoyment of the sport.

]]>
Lecture / Discussion Tue, 02 Mar 2021 12:15:45 -0500 2021-03-06T10:30:00-05:00 2021-03-06T11:30:00-05:00 Off Campus Location Saturday Morning Physics Lecture / Discussion U-M basketball players in action!
Complex Systems Seminar "Where models meet morality: What role should complexity science play in addressing racial and socioeconomic disparities in the COVID-19 crisis?" (March 9, 2021 11:30am) https://events.umich.edu/event/82461 82461-21106111@events.umich.edu Event Begins: Tuesday, March 9, 2021 11:30am
Location: Off Campus Location
Organized By: The Center for the Study of Complex Systems

ABSTRACT: Socioeconomic and racial inequalities in infection and mortality have been key features of the COVID-19 pandemic in the United States. While identifying these disparities is critical, it has also become clear that we lack the theoretical and methodological tools to integrate the mechanisms generating these inequities into models of infectious disease transmission. This is a huge gap, as such models have become key tools in developing policy and evaluating the impact of interventions ranging from social distancing to vaccination. In this talk, I will outline some of the work done by my research group that is focused on understanding the mechanistic drivers of spatial and socioeconomic variation in infection and death from SARS-CoV-2 in Michigan (see e.g. covidmapping.org) and conduct a walk-through of an interactive example of a model that attempts to integrate a key driver of infection inequality - residential segregation - into a model of infectious disease transmission. For more information, please visit our lab group site at epibayes.io.

]]>
Workshop / Seminar Wed, 24 Feb 2021 10:35:40 -0500 2021-03-09T11:30:00-05:00 2021-03-09T13:00:00-05:00 Off Campus Location The Center for the Study of Complex Systems Workshop / Seminar Jon Zelner, SPH
Residential College Zoom Chats for Prospective Students (March 11, 2021 3:00pm) https://events.umich.edu/event/82001 82001-21004767@events.umich.edu Event Begins: Thursday, March 11, 2021 3:00pm
Location: Off Campus Location
Organized By: Residential College

Chat with current RC students in a casual setting and learn more about the RC student experience!

>> Friday, 2/26/2021, 4-5pm ET

>> Thursday, 3/11/2021, 3-4pm ET

>> Monday, 4/5/2021, 6-7pm ET

Register via email at visittherc@gmail.com

]]>
Social / Informal Gathering Thu, 11 Feb 2021 09:35:11 -0500 2021-03-11T15:00:00-05:00 2021-03-11T16:00:00-05:00 Off Campus Location Residential College Social / Informal Gathering RC Zoom Chats flier
BME 500 Seminar: George Christ (March 11, 2021 4:00pm) https://events.umich.edu/event/81389 81389-20889819@events.umich.edu Event Begins: Thursday, March 11, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Despite the well-documented capability of skeletal muscle to repair, regenerate, and remodel following injury, there remain a multitude of diseases, disorders, and traumatic injuries that result in irrecoverable loss of muscle structure and function. For example, volumetric muscle loss (VML) injuries are characterized by a degree of composite muscle tissue loss so severe, that it exceeds the native ability of the muscle to repair, thereby resulting in permanent cosmetic and functional deficits to the limbs, neck, or face. These injuries significantly impact both the civilian and military populations. Current treatment for VML injury involves surgical muscle transfer, although these procedures are often associated with both poor engraftment and donor site morbidity, as well as incomplete cosmesis and functional recovery. Not surprisingly, this unmet medical need has stimulated research efforts to develop new technologies for treatment of VML injuries. Recent attention has focused on development of tissue engineering (TE)/regenerative medicine (RM) technologies to provide more effective treatment options for large scale muscle injuries. A variety of preclinical approaches have been tried that include implantation of synthetic and/or natural extracellular matrices/scaffolds/constructs at the site of VML injury, both with and without a cellular component. Extant data indicate that the inclusion of a cellular component generally leads to a greater degree of functional improvement. Consistent with these preclinical results, recent clinical studies for treatment of VML injury, solely with implanted decellularized extracellular matrix scaffolds, have provided evidence for modest functional recovery but with little de novo muscle tissue regeneration at the injury site. More recently, bio-printed tissue engineered constructs and their potential applications to treatment of VML injury have been reported in the literature. While these initial clinical and preclinical observations are encouraging for the TE/RM paradigm, full structural and functional recovery has yet to be achieved, and thus, there remains significant room for therapeutic advancement. To this end, I will describe our highly collaborative efforts to boost development and evaluation of a range of implantable regenerative therapeutics (biomaterials and tissue engineered constructs) in biologically relevant animal models. The overall goal is to increase the efficiency of clinical translation of TE/RM technologies capable of more complete functional recovery following repair of VML injury.

ZOOM LINK: https://umich.zoom.us/j/94405051853

]]>
Lecture / Discussion Mon, 08 Mar 2021 11:13:19 -0500 2021-03-11T16:00:00-05:00 2021-03-11T17:00:00-05:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
RNA Seminar featuring: James Nuñez, HHMI Hanna Gray Fellow, University of California, San Francisco (March 15, 2021 4:00pm) https://events.umich.edu/event/81286 81286-20881887@events.umich.edu Event Begins: Monday, March 15, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_f8wC8rrJQzuhYzTEXoW69Q


ABSTRACT
General approaches for heritably altering gene expression would enable many discovery and therapeutic efforts. I will present CRISPRoff— a programmable epigenetic memory writer consisting of a single dead Cas9 fusion protein that establishes DNA methylation and repressive histone modifications to turn off transcription. Transient CRISPRoff expression initiates highly specific DNA methylation and gene repression that is maintained through cell division and differentiation of stem cells to neurons. Pairing CRISPRoff with genome-wide screens and analysis of chromatin marks enabled us to explore the rules for heritable silencing. We identify sgRNAs capable of silencing the large majority of genes including those lacking canonical CpG islands (CGIs) and reveal a wide targeting window extending beyond annotated CGIs. Our finding that targeted DNA methylation outside of CGIs leads to memorized gene silencing expands the canonical model of methylation-based silencing and broadly enables diverse applications including genome-wide screens, multiplexed cell engineering, enhancer silencing, and mechanistic exploration of epigenetic inheritance.

KEYWORDS: CRISPR, transcription, epigenetics
Flyer in PDF: https://rna.umich.edu/wp-content/uploads/2021/02/Seminar-Flyer-03152021-Nunez.pdf

]]>
Lecture / Discussion Thu, 18 Feb 2021 09:21:31 -0500 2021-03-15T16:00:00-04:00 2021-03-15T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion James Nunez, Ph.D. UCSF
Science Success Series | Overcoming the Fear of Failure in Personal and Academic Pursuits (March 16, 2021 4:00pm) https://events.umich.edu/event/80594 80594-20759752@events.umich.edu Event Begins: Tuesday, March 16, 2021 4:00pm
Location: Off Campus Location
Organized By: Science Learning Center

In this workshop, we'll build on the lessons of growth mindset and put failure into practice, with activities that allow us to focus on the learning that goes along with mistakes. This way, we can create environments that allow for innovation, personal, and professional growth.

Register at: myumi.ch/1pBpO

]]>
Workshop / Seminar Mon, 11 Jan 2021 11:37:45 -0500 2021-03-16T16:00:00-04:00 2021-03-16T17:30:00-04:00 Off Campus Location Science Learning Center Workshop / Seminar you can('t) do it
TSCA @ 5 Years: Opportunities to Act with Foresight (March 16, 2021 7:00pm) https://events.umich.edu/event/82485 82485-21108121@events.umich.edu Event Begins: Tuesday, March 16, 2021 7:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

The University of Michigan M-LEEaD Center is co-sponsoring an event to mark the 5-year anniversary of the bipartisan legislation called the Frank R. Lautenberg Chemical Safety for the 21st Century Act. This reform law was designed to modernize U.S. industrial chemical policy to promote health, but has it lived up to its promise?

Public understanding is limited regarding how exposures to toxic chemicals affect health and how they might be regulated. Unlike pharmaceuticals, industrial and commercial chemicals are rarely tested for safety before they reach the U.S. market. The 1976 TSCA has been widely acknowledged to be a weak and ineffective law, and widespread exposures and harms continue. In the U.S., everyone is exposed to industrial and toxic chemicals, dozens and probably hundreds – well before birth. The amount of chemicals manufactured and imported continues to grow – it is trillions of pounds – and these chemicals remain largely unregulated. At the same time, we have seen an increase in chronic diseases, such as diabetes, autism, and infertility. Not everyone is equally at risk, and a higher burden of disease falls on low wealth communities and communities of color. These health disparities in exposures and health effects are illustrated and exacerbated by COVID.

The amended TSCA gave the U.S. Environmental Protection Agency new requirements and authorities. The public health impact points to the need for the U.S. EPA to fully use its new powers to evaluate all risks from hazardous chemicals and set policies which protect health and are accountable to high-risk communities. Preventive actions are urgently needed.

Watch “THE FOREVER CHEMICALS” documentary (2019, 26 min) at Great Lakes Now then join the March 16 forum. https://www.greatlakesnow.org/fc
“The Forever Chemicals” is an Emmy-winning examination of the impact of PFAS contamination in west Michigan
communities.

LEARN MORE AT OUR LIVE VIRTUAL PANEL DISCUSSION (registration required) on March 16 with Sandra Svoboda, “The Forever Chemicals” co-producer and Great Lakes Now Program Director; Tracey Woodruff, PhD, MPH, Professor, Ob/Gyn, Reproductive Sciences, University of CA-San Francisco; and Justin Onwenu, Environmental Justice Organizer, Sierra Club. Moderated by Patricia Koman, MPP, PhD, Research Investigator, Environmental Health Sciences, University of Michigan with Welcoming remarks from Gilbert S. Omenn, MD, PhD, the Harold T Shapiro Distinguished University Professor of Medicine (also Professor of Computational Medicine & Bioinformatics; Internal Medicine; Human Genetics; and Public Health, Univ of Mich).

REGISTER HERE https://bit.ly/37I2JaU

SPONSORED BY the Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD) • U-M Environmental Health Sciences • Detroit Public Television • Wayne State CURES Center • U-M Sustainable Living Experience • UROP (U-M Undergraduate Research Opportunity Program) • UMIHSA (U-M Industrial Hygiene Students Association) • EHSA (Environmental Health Student Association) • American Chemical Society Outreach Organization • U-M Health Policy Student Association • Ecology Center • Michigan Environmental Justice Coalition • UCSF Program for Reproductive Health and the Environment • UCSF EaRTH Center

]]>
Conference / Symposium Wed, 03 Mar 2021 12:57:09 -0500 2021-03-16T19:00:00-04:00 2021-03-16T20:30:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Conference / Symposium March 16 Panel Discussion: TSCA @ 5 Years
NeuroNetwork for Emerging Therapies Mini Symposium Series: Nutrition & Brain Health with The Henry Ford (March 18, 2021 2:00pm) https://events.umich.edu/event/82153 82153-21044613@events.umich.edu Event Begins: Thursday, March 18, 2021 2:00pm
Location: Off Campus Location
Organized By: NeuroNetwork for Emerging Therapies

"You are what you eat" is a common phrase that researchers and scientists are proving remarkably true. Unhealthy diets not only lead to obesity, but that obesity can even lead to cognitive decline, or a decreased ability to think.

The third installment of the NeuroNetwork for Emerging Therapies Mini Symposium Series will explore what unhealthy foods do to the nervous system, a historical look at the downhill trend of eating habits, and how everyone can find an optimal nutritional balance. These presentations will be followed by a question and answer session.

“Nutrition & Brain Health” is made possible by the generous support of Robert and Katherine Jacobs, who believe that informing people about healthy food options is critically important to the health of their community.

Eva Feldman, MD, PhD, Director of the NeuroNetwork for Emerging Therapies, will moderate the 30-minute mini symposium and discuss diet and brain health. Debra Reid, PhD, MA, Curator of Agriculture and the Environment at The Henry Ford, will discuss the history of the American diet and how urban residents obtained fresh fruits and vegetables from urban markets, such as the Central Farmers Market that is under reconstruction at Greenfield Village. Michigan Medicine Lead Dietitian Danielle Karsies, MS, RDN, will provide direction for how people can apply the information from Drs. Feldman and Reid to help them make better food choices.

]]>
Conference / Symposium Tue, 16 Feb 2021 13:46:27 -0500 2021-03-18T14:00:00-04:00 2021-03-18T14:30:00-04:00 Off Campus Location NeuroNetwork for Emerging Therapies Conference / Symposium Nutrition & Brain Health with The Henry Ford
BME 500 Seminar: Daniel Rueckert (March 18, 2021 4:00pm) https://events.umich.edu/event/81390 81390-20889820@events.umich.edu Event Begins: Thursday, March 18, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Zoom Link: https://cwru.zoom.us/webinar/register/WN_tmHJ7ArQRyO01NN6SfYYtg

Hosted by Dr. Frederick Epstein

Seminar Abstract:
The talk will focus on the use of deep learning techniques for the discovery and quantification of clinically useful information from medical images. The talk will describe how deep learning can be used for the reconstruction of medical images from undersampled data, image super-resolution, image segmentation and image classification. It will also show the clinical utility of applications of deep learning for the interpretation of medical images in applications such as brain tumour segmentation, cardiac image analysis and applications in neonatal and fetal imaging. Finally, it will be discussed how deep learning may change the future of medical imaging. https://openbme.org/

]]>
Lecture / Discussion Mon, 15 Mar 2021 14:07:10 -0400 2021-03-18T16:00:00-04:00 2021-03-18T17:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
RC Intros: Interested in learning more about the Residential College? (March 18, 2021 5:00pm) https://events.umich.edu/event/81793 81793-20959284@events.umich.edu Event Begins: Thursday, March 18, 2021 5:00pm
Location: Off Campus Location
Organized By: Residential College

RC Intros: Interested in learning more about the Residential College?

Curious what an RC class is like? Hear directly from RC faculty and ask questions about the RC academic experience!

Thursday, March 18, 5-6pm
Register at myumi.ch/zxXEx

]]>
Reception / Open House Fri, 05 Feb 2021 14:44:15 -0500 2021-03-18T17:00:00-04:00 2021-03-18T18:00:00-04:00 Off Campus Location Residential College Reception / Open House RC Intros flier
E. coli meets world: how the environment shapes a bacterial cell (March 19, 2021 12:00pm) https://events.umich.edu/event/82376 82376-21084383@events.umich.edu Event Begins: Friday, March 19, 2021 12:00pm
Location: Off Campus Location
Organized By: Department of Molecular, Cellular, and Developmental Biology

Abstract: Like other single celled organisms, bacteria are uniquely sensitive to changes in their physical and chemical environment. With only the minimal protection offered by their cell envelope, fluctuations in nutrient availability, pH, osmolarity, and temperature have an immediate impact on diverse aspects of cell physiology as bacteria struggle to adapt to the new condition. On a more extended time scale, nutrient availability is one of the major determinants of bacterial cell morphology. *Escherichia coli* cells are three times larger when cultured at steady state in nutrient rich conditions than in nutrient poor ones, due to the actions of nutrient-dependent division inhibitors, accelerated lipid synthesis and a concomitant increase in plasma membrane capacity, and other yet to be identified factors. Little is known, however, about the effect of other environmental conditions on bacterial cell morphology. Focusing on one environmental variable, I will discuss how modest changes in pH—too small to affect growth rate—alter the activity of the essential proteins that construct *E. coli*’s peptidoglycan cell wall, increase resistance to clinically relevant antibiotics, and reduce cell length by as much as 20%. Together this work identifies pH as a significant environmental determinant of bacterial physiology and morphogenesis whose impact is mediated primarily through changes in the cell envelope.

Host: Anthony Vecchiarelli

]]>
Workshop / Seminar Sun, 21 Feb 2021 17:56:49 -0500 2021-03-19T12:00:00-04:00 2021-03-19T13:30:00-04:00 Off Campus Location Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Petra Levin
Meet a Scientist (March 20, 2021 10:00am) https://events.umich.edu/event/82039 82039-21012671@events.umich.edu Event Begins: Saturday, March 20, 2021 10:00am
Location: Off Campus Location
Organized By: Museum of Natural History

Meet University of Michigan scientists and learn more about their cutting-edge research in this series of short, interactive presentations.
This virtual Zoom event is intended to be conversational with time built in for questions and discussion.
Saturday, March 20, 2021
10:00 a.m. - 12:00 p.m.
Free (Donations appreciated)

Presentations include topics in neurology, environmental engineering, psychology, chemistry, physics, evolutionary biology, and more!
Scientists are part of the University of Michigan Museum of Natural History's Science Communication Fellows program, aimed at bringing together researchers and the general public. This event is a virtual adaptation of the museum’s in-person Scientist Spotlight events.

For more information email ummnh.info@umich.edu.

Suggested donation $5 per person.

]]>
Livestream / Virtual Fri, 12 Feb 2021 07:17:53 -0500 2021-03-20T10:00:00-04:00 2021-03-20T12:00:00-04:00 Off Campus Location Museum of Natural History Livestream / Virtual Meet a Scientist Virtual Event
Saturday Morning Physics VIRTUAL Event | From Milkmaids to mRNA (March 20, 2021 10:30am) https://events.umich.edu/event/82125 82125-21036720@events.umich.edu Event Begins: Saturday, March 20, 2021 10:30am
Location: Off Campus Location
Organized By: Saturday Morning Physics

Dr. Fuller will give a pre-recorded Lecture and a Live Q&A.
Virtual Presentation Link: https://www.youtube.com/watch?v=5mN-qJmWRkI (Link will be active at 10:30 am on 03/20/21.)

The discovery that host immune defenses could be primed, a process called immunization or vaccination, helped to eradicate smallpox. Immunization has changed the global impacts of infectious diseases. Messenger RNA (mRNA) vaccines that have Emergency Use Authorization are one part of the toolkit for managing COVID-19. What is mRNA anyway? We will explore connections among mRNA, milkmaids and microbial pathogens.

We celebrate the James Robert Walker Lecture on this occasion.

]]>
Lecture / Discussion Mon, 15 Mar 2021 08:46:12 -0400 2021-03-20T10:30:00-04:00 2021-03-20T11:30:00-04:00 Off Campus Location Saturday Morning Physics Lecture / Discussion Image of Dr. Oveta Fuller
Representations of the Natural World from the Age of Sail: Mark Catesby, Sydney Parkinson, and John James Audubon (March 24, 2021 10:00am) https://events.umich.edu/event/79978 79978-20523448@events.umich.edu Event Begins: Wednesday, March 24, 2021 10:00am
Location: Off Campus Location
Organized By: Osher Lifelong Learning Institute (50+)

In 1712, Botanist Mark Catesby traveled to Virginia collecting seeds and specimens, beginning a decades-long journey towards publication of The Natural History of Carolina, Florida, and the Bahama Islands
(1731-1743).
In 1768, botanical draughtsman Sydney Parkinson joined Captain Cook's voyage to the Islands of Tahiti, in the employment of naturalist Joseph Banks. Although he died on the voyage, plates made from his sketches were preserved in the British Museum.
In 1819, businessman John James Audubon was bankrupted by a national financial crisis and set out on an expedition down the Mississippi River to pursue his dream of documenting America's avian life, ultimately leading to The Birds of America (1827-1838).
This study group led by Juli McLoone will meet Wednesday March 24.
Preregistration is required via the OLLI website or phone. A link to access the study group will be e-mailed to you approximately one week prior to the first session.

]]>
Class / Instruction Sat, 12 Dec 2020 11:37:34 -0500 2021-03-24T10:00:00-04:00 2021-03-24T11:00:00-04:00 Off Campus Location Osher Lifelong Learning Institute (50+) Class / Instruction Study Group
Where Do We Go From Here: Body Politics & Movement Towards Racial Empowerment (March 24, 2021 12:00pm) https://events.umich.edu/event/82828 82828-21179596@events.umich.edu Event Begins: Wednesday, March 24, 2021 12:00pm
Location: Off Campus Location
Organized By: School of Kinesiology

Please join us for the last event in our series addressing the theme: "Where Do We Go From Here: Body Politics and Movement Towards Racial Empowerment."

This event will consist of a panel featuring scholars and medical, mental health, and fitness experts discussing movement, and physical and mental wellness/well-being as ways of combatting the body politics of racism. The event will include panelists’ demonstrations and audience participation.

If you'd like to join along with the Afrobeats dance demonstration (and we hope you do), please wear comfortable clothes and use a space where you have room to move. All ages and abilities are welcome; no experience needed!

--Abigail Eiler, LMSW, MSW, QMHP: Clinical Assistant Professor, U-M School of Social Work; Director, Athletics Counseling, U-M Athletics; Chair, Mental Health & Wellness Cabinet, Big Ten Conference

--Chiamaka Ukachukwu, MS: PhD Candidate (Specializing in Cardiovascular Electrophysiology), U-M Department of Pharmacology; Afrobeats Dance Instructor, U-M Recreational Sports

--Dr. Kamaria Washington, DPT: Physical Therapist (Specializing in Pelvic Floor Concerns), Therapeutic Associates Bethany Physical Therapy (Portland, OR)

]]>
Well-being Wed, 17 Mar 2021 17:58:46 -0400 2021-03-24T12:00:00-04:00 2021-03-24T13:30:00-04:00 Off Campus Location School of Kinesiology Well-being U-M Health Sciences - Where Do We Go From Here: Body Politics & Movement Towards Racial Empowerment
5th Annual RNA Symposium, "Processing RNA" (March 25, 2021 11:00am) https://events.umich.edu/event/80161 80161-20572609@events.umich.edu Event Begins: Thursday, March 25, 2021 11:00am
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

FOR MORE DETAILS & ABSTRACTS VISIT: https://rna.umich.edu/2021-symposium/

Thursday, March 25, 2021
11:00 / Welcome
11:05 / KEYNOTE 1: Tracy Johnson, UCLA, “RNA Splicing, Chromatin Modification, and the Coordinated Control of Gene expression”
12:00 / Short break
12:10 / KEYNOTE 2: Kevin Weeks, UNC, “Structure-Based Discovery of New Functions in Large RNAs”
1:05 / Data Blitz: Cathy Smith, Daniel Peltier, Yan Zhang
1:35 / KEYNOTE 3: Feng Zhang, MIT, “Exploration of Biological Diversity to Discover Novel Molecular Technologies”
2:30 / Close Day 1

Friday, March 26, 2021
11:00 / Welcome
11:05 / KEYNOTE 4: Brenda Bass, University of Utah, “Distinguishing self and non-self dsRNA in vertebrates and invertebrates”
12:00 / Short break
12:10 / KEYNOTE 5: Christopher Lima, Sloan-Kettering Institute, “Mechanisms that target RNA for destruction”
1:05 / Data Blitz: Meredith Purchal, Adrien Chauvier, Shannon Wright
1:35 / Panel discussion with keynote speakers
2:30 / Close Day 2

Liveblogging by MiSciWriters! https://misciwriters.com/

]]>
Lecture / Discussion Tue, 23 Mar 2021 15:03:26 -0400 2021-03-25T11:00:00-04:00 2021-03-25T14:30:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion 5th Annual RNA Symposium
BME 500 Seminar: Warren L. Grayson (March 25, 2021 4:00pm) https://events.umich.edu/event/81391 81391-20889821@events.umich.edu Event Begins: Thursday, March 25, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Tissue engineering provides a viable means of regenerating bone and skeletal muscle tissues following injuries that lead to large volumetric defects. Our lab has developed advanced biomaterial and stem cell-based approaches to promote functional recovery following volumetric muscle loss and critical-sized craniofacial bone injuries. This presentation will focus on three areas of ongoing research: (1) I will present our lab’s efforts to regenerate vascularized and innervated skeletal muscle in mice including our recent studies using human pluripotent stem cells. (2) Recently, our group completed a study focused on designing biomaterials to guide bone regeneration in situ in minipigs using intraoperative protocols for combining autologous stem cells with 3D-printed scaffolds. (3) Understanding the interaction between vascular cells and osteoprogenitors is critical for developing effective treatment methods. I will describe recent studies in which we developed a quantitative imaging platform for characterizing the spatial relationships between cell populations in the native murine calvarium. https://openbme.org/

ZOOM LINK TO REGISTER: https://cwru.zoom.us/webinar/register/WN_Kgyl3yf4TcKvlk9xNKluhA

]]>
Lecture / Discussion Sun, 21 Mar 2021 17:46:23 -0400 2021-03-25T16:00:00-04:00 2021-03-25T17:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
5th Annual RNA Symposium, "Processing RNA" (March 26, 2021 11:00am) https://events.umich.edu/event/80161 80161-20572610@events.umich.edu Event Begins: Friday, March 26, 2021 11:00am
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

FOR MORE DETAILS & ABSTRACTS VISIT: https://rna.umich.edu/2021-symposium/

Thursday, March 25, 2021
11:00 / Welcome
11:05 / KEYNOTE 1: Tracy Johnson, UCLA, “RNA Splicing, Chromatin Modification, and the Coordinated Control of Gene expression”
12:00 / Short break
12:10 / KEYNOTE 2: Kevin Weeks, UNC, “Structure-Based Discovery of New Functions in Large RNAs”
1:05 / Data Blitz: Cathy Smith, Daniel Peltier, Yan Zhang
1:35 / KEYNOTE 3: Feng Zhang, MIT, “Exploration of Biological Diversity to Discover Novel Molecular Technologies”
2:30 / Close Day 1

Friday, March 26, 2021
11:00 / Welcome
11:05 / KEYNOTE 4: Brenda Bass, University of Utah, “Distinguishing self and non-self dsRNA in vertebrates and invertebrates”
12:00 / Short break
12:10 / KEYNOTE 5: Christopher Lima, Sloan-Kettering Institute, “Mechanisms that target RNA for destruction”
1:05 / Data Blitz: Meredith Purchal, Adrien Chauvier, Shannon Wright
1:35 / Panel discussion with keynote speakers
2:30 / Close Day 2

Liveblogging by MiSciWriters! https://misciwriters.com/

]]>
Lecture / Discussion Tue, 23 Mar 2021 15:03:26 -0400 2021-03-26T11:00:00-04:00 2021-03-26T14:30:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion 5th Annual RNA Symposium
Molecular Genetics in the Orchard (March 26, 2021 12:00pm) https://events.umich.edu/event/82378 82378-21086350@events.umich.edu Event Begins: Friday, March 26, 2021 12:00pm
Location: Off Campus Location
Organized By: Department of Molecular, Cellular, and Developmental Biology

Fruit trees in commercial orchards are increasingly planted in high densities to maximize quality, enable mechanization, conserve resources, and increase profitability. A hundred years ago a traditional apple orchard may have had one to two hundred free standing trees per acre, while now planting over a thousand tree per acre trained to elaborate trellis systems is common practice. To maintain such high-density plantings, a significant amount of labor is needed along with growth regulator treatments and, in some cases, specialized dwarfing rootstocks. Still, not all fruit trees are easily amenable to growing in these systems. One of the focuses of my research program is to determine what controls fruit tree shoot architecture at the molecular and genetic level. The ultimate goal of this project is to identify methods that will reduce the labor required to manage high-density 2-dimensional plantings. In the process, we are generating fundamental knowledge about how plants grow the way they do, particularly in connection to the regulation of branch, or lateral shoot, angle. The main genes we are studying are TILLAR ANGLE CONTROL 1 (TAC1), LAZY1, and WEEP, which are present in vascular plants. TAC1 promotes the formation of wide branch angles, while the related gene LAZY1 promotes narrow branch angles. WEEP on the other hand regulates branch tip orientations. Peach trees with a non-functional WEEP allele exhibit a weeping branch phenotype. Genetic studies have linked the roles of these three genes together, and molecular and physiological studies suggest they have roles in regulating shoot growth in response to light and gravity. For this talk, I will present current and developing knowledge about their molecular mechanisms in connection to the regulation of lateral shoot orientations in plants.

Host: Cora MacAlister

]]>
Workshop / Seminar Thu, 25 Mar 2021 15:59:50 -0400 2021-03-26T12:00:00-04:00 2021-03-26T13:30:00-04:00 Off Campus Location Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Courtney Hollender portrait with background photo of apple blossoms
Webinar: Understanding the Role Coastal Marshes Play in Protecting Communities from Storm Surge and Flooding (March 31, 2021 3:00pm) https://events.umich.edu/event/83387 83387-21369771@events.umich.edu Event Begins: Wednesday, March 31, 2021 3:00pm
Location: Off Campus Location
Organized By: Graham Sustainability Institute

As coastal communities strive to safeguard themselves from increasing storm risks, they are looking for ways to maximize the protective powers of their natural features such as coastal wetlands. This project closely examined one marsh complex that lies adjacent to Piermont Village along the Hudson River Estuary in New York. Village residents wanted to better understand how Piermont Marsh would buffer their village from storm-induced flooding and waves, and whether a proposed plan to restore native cattails within a small area of the Phragmites-dominated marsh would lessen its buffering capacity.

In this webinar, two members of the project team will explain how the team used state of the art modeling methods to simulate marsh vegetation and storm impacts produced by a series of past and future storm scenarios. By looking back at Superstorm Sandy in 2012 and projecting how much worse the damage could have been without the marsh, the research team was able to put a dollar value on Piermont Marsh’s buffering services. They will share key takeaways from the research and explain how the findings are informing planning for the marsh and shoreline infrastructure.

]]>
Workshop / Seminar Mon, 29 Mar 2021 13:24:38 -0400 2021-03-31T15:00:00-04:00 2021-03-31T16:00:00-04:00 Off Campus Location Graham Sustainability Institute Workshop / Seminar
BME 500 Seminar: Tim Downing (April 1, 2021 4:00pm) https://events.umich.edu/event/81392 81392-20889822@events.umich.edu Event Begins: Thursday, April 1, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

https://openbme.org/

ZOOM LINK TO REGISTER: https://cwru.zoom.us/webinar/register/WN_iY_PMZevQwWRYkMyK7ifzA

]]>
Lecture / Discussion Fri, 26 Mar 2021 14:01:59 -0400 2021-04-01T16:00:00-04:00 2021-04-01T17:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
The Van Loo Family Saturday Morning Physics VIRTUAL Event | Graduate Student Presentations (April 3, 2021 10:30am) https://events.umich.edu/event/82127 82127-21036722@events.umich.edu Event Begins: Saturday, April 3, 2021 10:30am
Location: Off Campus Location
Organized By: Saturday Morning Physics

Pre-recorded lecture followed by “live” Q&A
Virtual Presentation Link: https://www.youtube.com/watch?v=tc340N56GvY

Instruments to Study Rocket Plume Surface Interactions (PSI) on the Lunar Surface
Ariana Bueno (U-M Climate and Space Sciences and Engineering & Applied Physics)
In space exploration, the rocket plume-surface interaction (PSI) can lead to the ejection of large amounts of energetic particles, potentially damaging the spacecraft, its instruments, and associated hardware. Thus, understanding PSI processes is paramount to the safety of the lunar exploration program and beyond. In this presentation, Ariana will highlight how her research has led to a better understanding of PSI by developing in-flight instrumentation and conducting ground tests to simulate PSI.

Histotripsy: Crushing Cancer Cells with Acoustic Cavitation
Ryan Hubbard (U-M Biomedical Engineering & U-M Applied Physics)
Histotripsy is a non-invasive cancer-treatment approach using focused beams of ultrasound. In this presentation, Ryan will highlight the results of his research, illustrating histotripsy's ability to destroy tumor cells and elicit anti-tumor immune responses. He will describe the basics behind ultrasonic pulse generation, acoustic cavitation, and how the mechanism of histotripsy compares to other external beam treatments such as X-ray irradiation.

We celebrate the Van Loo Family Lecture on this occasion.

]]>
Lecture / Discussion Tue, 23 Mar 2021 11:04:35 -0400 2021-04-03T10:30:00-04:00 2021-04-03T11:30:00-04:00 Off Campus Location Saturday Morning Physics Lecture / Discussion
RNA Seminar featuring: Natoya Peart, PhD, University of Pennsylvania (April 5, 2021 4:00pm) https://events.umich.edu/event/81288 81288-20881888@events.umich.edu Event Begins: Monday, April 5, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

Registration required: https://umich.zoom.us/webinar/register/WN_0lUfePb0Qdac-cQZDpeiEQ


KEYWORDS: Alternative splicing, RNAMap, Esrp1

ABSTRACT: Coordinated regulation of alternative splicing is essential to the establishment of cell identity. The Epithelial Splicing Regulatory Proteins (Esrps), ESRP1 and ESRP2, are highly conserved paralogous proteins required for organogenesis of multiple organ systems and compromised function of Esrps contributes to human diseases and pathologies. Esrps are robustly expressed in the epithelial cells of the epidermis, large and small intestines, salivary glands, stomach, and a variety of other tissues, where they are vital in promoting an epithelial splicing network. Although ESRP1 and ESRP2 share partial functional redundancy, ESRP1 appears to play a larger role in regulating gene expression.
Using a combination of enhanced immunoprecipitation coupled with high throughput sequencing (eCLIP) in the epithelial cells of mouse epidermis and RNA sequencing analysis of alterations in splicing and total gene expression that result from epidermal ablation of Esrp1 and Esrp2 we generate a map of Esrp1 binding to RNA. We show that ESRP1 regulates splicing primarily through direct binding in a position-dependent manner to either promote exon inclusion or skipping. In particular, we show that Esrp1 binding upstream of or withing alternatively spliced exons suppresses exon inclusion, whilst binding downstream of the non-constitutive exon promotes exon inclusion. In addition, we identified widespread binding of ESRP1 in 3’ and 5’ untranslated regions (UTRs) of genes enriched for epithelial cell function suggesting that it directly regulates post-transcriptional gene expression steps in addition to splicing.


If you are having difficulties registering, please contact Martina Jerant at mjerant@umich.edu

]]>
Lecture / Discussion Mon, 08 Mar 2021 12:23:08 -0500 2021-04-05T16:00:00-04:00 2021-04-05T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Natoya Peart, PhD, University of Pennsylvania
Residential College Zoom Chats for Prospective Students (April 5, 2021 6:00pm) https://events.umich.edu/event/82001 82001-21004768@events.umich.edu Event Begins: Monday, April 5, 2021 6:00pm
Location: Off Campus Location
Organized By: Residential College

Chat with current RC students in a casual setting and learn more about the RC student experience!

>> Friday, 2/26/2021, 4-5pm ET

>> Thursday, 3/11/2021, 3-4pm ET

>> Monday, 4/5/2021, 6-7pm ET

Register via email at visittherc@gmail.com

]]>
Social / Informal Gathering Thu, 11 Feb 2021 09:35:11 -0500 2021-04-05T18:00:00-04:00 2021-04-05T19:00:00-04:00 Off Campus Location Residential College Social / Informal Gathering RC Zoom Chats flier
Molecular Basis of Inherited Parkinson’s disease (April 9, 2021 1:00pm) https://events.umich.edu/event/82439 82439-21098220@events.umich.edu Event Begins: Friday, April 9, 2021 1:00pm
Location: Off Campus Location
Organized By: Department of Molecular, Cellular, and Developmental Biology

Note: change in time to 1 PM

Abstract: Today more than 1 million people in the U.S. suffer from Parkinson’s disease, and although most cases are idiopathic,perhaps as many as 20% of cases have a genetic basis. We study the effect of mutations in the LRRK2 kinase that is the most frequent cause of inherited Parkinson’s. Pathogenic LRRK2 phosphorylates a subset of Rab GTPases that are
master regulators of membrane trafficking. We have discovered that Rab10 phosphorylation flips a switch on its function —phosphoRab10 bind an entirely new set of effectors that regulate the formation of primary cilia in cell culture and mouse brain. We are also studying regulation of LRRK2 by the PPM1H phosphatase and how loss of cilia could trigger Parkinson’s disease.

Host: Ming Li

]]>
Workshop / Seminar Thu, 25 Mar 2021 16:02:03 -0400 2021-04-09T13:00:00-04:00 2021-04-09T14:30:00-04:00 Off Campus Location Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Suzanne Pfeffer