Happening @ Michigan https://events.umich.edu/list/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. RNA Collaborative Seminar featuring: Sue Hammoud, Human Genetics & Justin Colacino, Environmental Health Sciences (September 9, 2020 4:00pm) https://events.umich.edu/event/75865 75865-19615931@events.umich.edu Event Begins: Wednesday, September 9, 2020 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

ZOOM REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_GjVNcoWtRG6OkzxSDmfb8A

"Same Same Different: Single cell RNAseq identifies conserved and divergent features of mammalian spermatogenesis"
Sue Hammoud, Ph.D.
Assistant Professor of Human Genetics
Website: https://hammoud.lab.medicine.umich.edu/

~and~

"Single cell transcriptomic profiling to understand breast stem cell heterogeneity in development and cancer disparities"
Justin Colacino. Ph.D.
Assistant Professor of Environmental Health Sciences
Website: https://www.colacinolab.com/

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Lecture / Discussion Wed, 26 Aug 2020 11:44:32 -0400 2020-09-09T16:00:00-04:00 2020-09-09T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion RNA Collaborative
Identifying Emergency Funds and How to Advocate for Making Room in Your Financial Aid Package (September 11, 2020 2:00pm) https://events.umich.edu/event/75507 75507-19513173@events.umich.edu Event Begins: Friday, September 11, 2020 2:00pm
Location: Off Campus Location
Organized By: CEW+

Advance registration is required; look for the Zoom link at the bottom of your confirmation email after registering.

This session will provide information about how you can seek emergency funds should you experience an emergency situation or one-time, unusual, unforeseen expense while in school. Information about the types of situations that qualify for emergency funds and where to seek funding will be covered during this presentation.

RSVP HERE: http://www.cew.umich.edu/events/identifying-emergency-funds-and-how-to-advocate-for-making-room-in-your-financial-aid-package

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Livestream / Virtual Tue, 18 Aug 2020 14:02:34 -0400 2020-09-11T14:00:00-04:00 2020-09-11T15:00:00-04:00 Off Campus Location CEW+ Livestream / Virtual A jar of spilled change
LHS Collaboratory Seminar Series Virtual Kick-Off: Academic Medical Centers as Learning Health Systems (September 17, 2020 9:00am) https://events.umich.edu/event/75856 75856-19615923@events.umich.edu Event Begins: Thursday, September 17, 2020 9:00am
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Learning Health Systems (LHS) methods are now being implemented in interesting and varying ways by academic health centers and their clinical and translational science institutes across the country.
According to the Agency for Healthcare Research and Quality (AHRQ), the following are key attributes of Learning Health
Systems:

• Having leaders who are committed to a culture of continuous learning and improvement
• Systematically gathering and applying evidence in real-time to guide care
• Employing IT methods to share new evidence with clinicians to improve decision-making
• Promoting the inclusion of patients as vital members of the learning team
• Capturing and analyzing data and care experiences to improve care
• Continually assessing outcomes, refining processes and training to create a feedback cycle for learning and improvement

The LHS Collaboratory's fall seminar series virtual kick-off event will showcase the LHS experiences of three research-intensive academic centers that have been promoting LHS methods. We will be joined by distinguished senior colleagues from Duke,Vanderbilt, and Washington University, who will describe and discuss their institutions' work in this area. They will discuss strategies employed, investments made, challenges encountered, and successes achieved.

Panelists:
Kevin B. Johnson, MD, MS, FAAP, FACMI, Vanderbilt University
Christopher J. Lindsell, PhD, Vanderbilt University
Philip Payne, PhD, FACMI, Washington University
Michael Pencina, PhD, Duke University
Eric G. Poon, MD, MPH, Duke University

Discussant:
Carol R. Bradford, MD, MS, Executive Vice Dean for Academic Affairs, University of Michigan Medical School, Chief Academic Officer, Michigan Medicine, Professor of Otolaryngology-Head and Neck Surgery

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Lecture / Discussion Thu, 20 Aug 2020 09:45:31 -0400 2020-09-17T09:00:00-04:00 2020-09-17T11:00:00-04:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion LHS Collaboratory Logo-blocks
RNA Seminar featuring: Andrey Krasilnikov, Penn State (September 21, 2020 4:00pm) https://events.umich.edu/event/75802 75802-19608017@events.umich.edu Event Begins: Monday, September 21, 2020 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

ZOOM REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_obckKUCLT4mXI7kPskzc-Q

KEYWORDS: Ribozymes, RNase P, RNase MRP, ribonucleoprotein complexes, RNA-driven protein remodelling

ABSTRACT: Ribonuclease (RNase) P is a ribozyme-based catalytic ribonucleoprotein complex involved primarily in the maturation of tRNA in all three domains of life. In the course of evolution, the size and complexity of RNase P grew as the catalytic RNA moiety recruited additional protein components. In eukaryotes, the RNase P lineage has split, giving rise to a related RNP enzyme called RNase MRP, which shares multiple structural features (including most of the protein components) with the eukaryotic RNase P, but has a distinct and non-overlapping specificity. We report the recently solved cryo-EM structure of the 450 kDa yeast RNase MRP holoenzyme and compare it with the structure of its progenitor RNP, RNase P. We show that, surprisingly, several of the proteins shared by RNase MRP and RNase P undergo RNA-driven structural remodeling, allowing the same proteins to function in distinct structural contexts. This remodeling, combined with altered peripheral RNA elements, results in the functional diversification of the two closely related RNPs, in spite of the structural conservation of the nearly identical catalytic cores, demonstrating structural underpinnings of the acquisition of new functions by catalytic RNPs.

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Lecture / Discussion Thu, 17 Sep 2020 07:12:03 -0400 2020-09-21T16:00:00-04:00 2020-09-21T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Andrey Krasilnikov, Penn State
2020 Precision Health Virtual Symposium (September 23, 2020 8:45am) https://events.umich.edu/event/75090 75090-19216540@events.umich.edu Event Begins: Wednesday, September 23, 2020 8:45am
Location: Off Campus Location
Organized By: Precision Health

Join us for a full-day virtual event celebrating and exploring the latest research in the fast-moving, multidisciplinary field of precision health.

This year's event focuses on the engagement of community participants to do research and the positive impact research can have on communities. Featuring national and local experts from engineering, medicine, nursing, pharmacy, public health, and many other areas, this event will provide thought-provoking sessions from multiple perspectives.

The morning session is geared toward researchers, with speakers sharing best practices and the importance of engaging a community. The afternoon session will be appropriate for both research participants and researchers, as we focus on the impact of research on community. You may attend either or both sessions. All are welcome.

A virtual poster session will feature work by funded Precision Health Investigators and other invited research groups.

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Livestream / Virtual Mon, 24 Aug 2020 14:37:59 -0400 2020-09-23T08:45:00-04:00 2020-09-23T15:15:00-04:00 Off Campus Location Precision Health Livestream / Virtual 2020 Precision Health Virtual Symposium
RNA Seminar featuring: Hiroaki Suga, University of Tokyo (September 28, 2020 9:00am) https://events.umich.edu/event/75805 75805-19608020@events.umich.edu Event Begins: Monday, September 28, 2020 9:00am
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

ZOOM REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_PBHPayAvR8WobaSf3z0AUA

ABSTRACT: Macrocyclic peptides possess a number of pharmacological characteristics distinct from other well-established therapeutic molecular classes, resulting in a versatile drug modality with a unique profile of advantages. Macrocyclic peptides are accessible by not only chemical synthesis but also ribosomal synthesis. Particularly, recent inventions of the genetic code reprogramming integrated with an in vitro display format, referred to as RaPID (Random non-standard Peptides Integrated Discovery) system, have enabled us to screen mass libraries (>1 trillion members) of non-standard peptides containing multiple non-proteinogenic amino acids, giving unique properties of peptides distinct from conventional peptides, e.g. greater proteolytic stability, higher affinity (low nM to sub nM dissociation constants similar to antibodies), and superior pharmacokinetics. The field is rapidly growing evidenced by increasing interests from industrial sectors, including small start-ups as well as mega-pharmas, toward drug development efforts on macrocyclic peptides, which has led to several de novo discovered peptides entering clinical trials. This lecture discusses the aforementioned screening technology involving the method of “genetic code reprogramming” powered by flexizymes, and several showcases of therapeutic potentials of macrocyclic peptides.

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Lecture / Discussion Sun, 20 Sep 2020 13:22:07 -0400 2020-09-28T09:00:00-04:00 2020-09-28T10:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Hiroaki Suga, University of Tokyo
A Cross-Disciplinary Perspective on Healthcare Delivery in Low- and Middle-Income Countries (September 28, 2020 4:30pm) https://events.umich.edu/event/77054 77054-19790563@events.umich.edu Event Begins: Monday, September 28, 2020 4:30pm
Location: Off Campus Location
Organized By: William Davidson Institute

Healthcare delivery in low- and middle-income countries (LMICs) is influenced by many factors, such as provider expertise, patient trust, access, financing, policies and evolving technology. Improving how healthcare is delivered in LMICs requires a strong understanding of the various disciplinary approaches to care and how they can vary between cultures. With leading faculty from the U-M Medical School, the School of Nursing, College of Pharmacy and School of Public Health, this panel will explore: *“A Cross-Disciplinary Perspective on Healthcare in Low- and Middle-Income Countries.”*

This virtual public session will also serve as the opening discussion of a course with the same name (BA620) offered in the second half of the Fall semester.

For questions about the roundtable discussion or the course, please contact Ekta Jhaveri at ekta@umich.edu

Panelists include:
Vicki Ellingrod, College of Pharmacy
Joe Kolars, U-M Medical School
Jody Lori, School of Nursing
Abram L. Wagner, School of Public Health

Moderator: Paul Clyde, WDI & Michigan Ross

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Lecture / Discussion Thu, 10 Sep 2020 15:52:46 -0400 2020-09-28T16:30:00-04:00 2020-09-28T17:30:00-04:00 Off Campus Location William Davidson Institute Lecture / Discussion Image with event details and headshots of panelists
Center for Global Health Equity Introductory Seminar (September 29, 2020 5:00pm) https://events.umich.edu/event/77700 77700-19901736@events.umich.edu Event Begins: Tuesday, September 29, 2020 5:00pm
Location: Off Campus Location
Organized By: Center for Global Health Equity

Please join us for the Introductory Seminar for the Center for Global Health Equity, where we will discuss:
What is the purpose of the Center?
What has been our journey to date?
Where are we going?

Speakers Include:
Bhramar Mukherjee, PhD
Nancy Love, PhD
Joseph Kolars, MD
John Ayanian, MD, MPP
Laura Rozek, PhD
Andries Coetzee, PhD

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Workshop / Seminar Thu, 24 Sep 2020 16:32:00 -0400 2020-09-29T17:00:00-04:00 2020-09-29T18:30:00-04:00 Off Campus Location Center for Global Health Equity Workshop / Seminar Event Speakers
RNA Seminar featuring: Chase Weidmann, Washington University School of Medicine in St. Louis (October 5, 2020 4:00pm) https://events.umich.edu/event/76147 76147-19665691@events.umich.edu Event Begins: Monday, October 5, 2020 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

ZOOM REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_y9HTFl5RSOSJTJ5qtlhVcw

Keywords: mRNA regulation, noncoding RNA, RNA Structure, RNP granules

Abstract:
Chase Weidmann, Ph.D. has contributed broadly to the field of RNA Biology during his career, studying mechanisms of codon bias during translation, post-transcriptional regulation of mRNAs by RNA-binding proteins, the folding of long non-coding RNAs, and how RNA-protein interaction networks contribute to the function and assembly of functional RNP particles. Chase developed a chemical probing strategy and next-gen sequencing technology, called RNP-MaP, that maps the location of and cooperation between multi-protein networks on RNAs in live cells. Going forward, Chase is interested in understanding how alterations in RNA-binding protein profiles, a cell’s “RBPome”, confer deleterious activities onto noncoding RNAs in human disease, especially in cancer. To further empower this work and his future research program, Chase is now generating and integrating protein mass spectrometry data into his RBPome projects.

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Lecture / Discussion Wed, 16 Sep 2020 09:01:52 -0400 2020-10-05T16:00:00-04:00 2020-10-05T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion photo
RNA Seminar featuring: Gene Yeo, University of California, San Diego (October 19, 2020 4:00pm) https://events.umich.edu/event/75807 75807-19608023@events.umich.edu Event Begins: Monday, October 19, 2020 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

ZOOM REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_CcI2trSATJy47aGtwrzhew

Abstract: The life-cycle of RNA from transcription to translational regulation is mediated by a diverse (>2000) set of proteins called RNA binding proteins. My lab studies the many roles that RNA binding proteins have in affecting RNA expression, splicing, transport and translation. Through our studies on RNA processing, we have introduced therapeutic strategies to treat neurodegenerative and muscular diseases, built cellular models of neurodevelopmental and neurodegenerative diseases and developed experimental and computational tools that enable the community to probe RNA binding protein-RNA interactions at scale. I will discuss (1) our established and new technologies to identify RNA targets of human RBPs at scale, (2) systematic assays to assign molecular roles to RBPs and (2) functional screens to identify RBPs implicated in cancer / RNA granule formation.

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Lecture / Discussion Wed, 16 Sep 2020 09:57:16 -0400 2020-10-19T16:00:00-04:00 2020-10-19T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Gene Yeo, University of California, San Diego
LHS Collaboratory-LHS as a Driver of Diversity, Equity, and Inclusion (October 20, 2020 11:30am) https://events.umich.edu/event/77545 77545-19879862@events.umich.edu Event Begins: Tuesday, October 20, 2020 11:30am
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Healthcare and health remain unconscionably inequitable. This year, the disproportionate toll the COVID-19 pandemic has taken on those historically least well-served by our health system, has highlighted the pressing societal challenge of health disparities.

Beyond simply striving to do no harm, Learning Health Systems (LHSs) have the potential to serve as forces for justice in healthcare and health; indeed, they can be powerful drivers of diversity, equity, and inclusion. LHSs are anchored in multi-stakeholder consensus Core Values that explicitly incorporate principles such as inclusiveness, transparency, and accessibility. Their proximal goal is "to efficiently and equitably serve the learning needs of all participants, as well as the overall public good."

The October 2020 LHS Collaboratory will share lessons from health advocates working on the front lines to make healthcare and health more equitable. These thought leaders and do-ers will illuminate the transformative power of LHSs - and the diverse and inclusive communities of interest that are collaborating to realize them.

Moderator:
Joshua C. Rubin, JD, MBA, MPP, MPH
Program Officer, Learning Health System Initiatives, Department of Learning Health Sciences, University of Michigan

Panelists:
Luis Belén
Chief Executive Officer of the National Health IT Collaborative for the Underserved (NHIT Collaborative)

Danielle Brooks, JD
Director of Health Equity, Amerihealth Caritas

Melissa S. Creary, PhD, MPH, Assistant Professor
Department of Health Management and Policy
School of Public Health, University of Michigan

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Lecture / Discussion Sun, 27 Sep 2020 21:18:37 -0400 2020-10-20T11:30:00-04:00 2020-10-20T13:00:00-04:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion LHS Collaboratory Logo puzzle pieces
University of Michigan College of Pharmacy Virtual Open House (MS & PhD Programs) (October 22, 2020 6:00pm) https://events.umich.edu/event/78326 78326-20010764@events.umich.edu Event Begins: Thursday, October 22, 2020 6:00pm
Location: Off Campus Location
Organized By: U-M College of Pharmacy

The University of Michigan College of Pharmacy Virtual Open House will give you an opportunity to learn more about the graduate (MS & PhD) programs that are offered in the College of Pharmacy. This event will begin with an overview presentation featuring our MS program in Integrated Pharmaceutical Sciences and our PhD programs in Medicinal Chemistry, Pharmaceutical Sciences and Clinical Pharmacy Translational Science. This presentation will be followed by a virtual poster session with graduate students from each program. Opportunities for Q & A with faculty members will also be available.

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Reception / Open House Thu, 08 Oct 2020 09:01:57 -0400 2020-10-22T18:00:00-04:00 2020-10-22T20:30:00-04:00 Off Campus Location U-M College of Pharmacy Reception / Open House PhD students at Research Forum
RNA Seminar featuring: Aleksandra Filipovska, University of Western Australia (October 26, 2020 9:00am) https://events.umich.edu/event/75809 75809-19608025@events.umich.edu Event Begins: Monday, October 26, 2020 9:00am
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

ZOOM REGISTRATION REQUIRED:https://umich.zoom.us/webinar/register/WN_f8wC8rrJQzuhYzTEXoW69Q

ABSTRACT:Mitochondria produce more than 90% of the energy required by our bodies and thereby have a fundamental role in cell and energy metabolism. Mitochondria are composed of proteins encoded by both the nuclear and mitochondrial genomes and the coordinated expression of both genomes is essential for energy production. Impaired energy production leads to mitochondrial dysfunction that causes or contributes significantly to a variety of diseases including metabolic disorders and cardiovascular diseases. Mitochondrial dysfunction is caused by mutations in nuclear or mitochondrial genes that encode proteins or regulatory RNAs essential for mitochondrial biogenesis. How uncoordinated gene expression causes mitochondrial dysfunction and compromised energy production in heart and metabolic diseases is poorly understood, making it difficult to develop effective treatments. To unravel how mitochondrial function fails and to identify therapeutic targets it is necessary (i) to understand how gene expression is regulated between mitochondria and the nucleus and (ii) how this regulation is disrupted in disease. We have created new and unique models of metabolic and cardiovascular diseases caused by mutations or loss of nuclear encoded RNA-binding proteins (RBPs) that regulate mitochondrial RNA metabolism and protein synthesis. These new models have identified that energy dysfunction can differentially affect specific organs such as the heart or liver, or multiple organs leading to heart failure or metabolic diseases that can be devastating, such as mitochondrial diseases, or may be as common as insulin resistance and obesity. I will discuss the mechanisms behind these diverse pathologies caused by impaired gene expression and energy dysfunction in heart and metabolic disease.

KEYWORDS: mitochondria, RNA, ribosomes, translation

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Lecture / Discussion Tue, 20 Oct 2020 14:16:54 -0400 2020-10-26T09:00:00-04:00 2020-10-26T10:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion photo
Be a Hero at the Big House (November 1, 2020 8:00am) https://events.umich.edu/event/78304 78304-20004863@events.umich.edu Event Begins: Sunday, November 1, 2020 8:00am
Location:
Organized By: Wolverines for Life

Join us for our largest event of the year. In consideration of the pandemic, we'll be converting this event to a hybrid virtual/in-person experience. Keep an eye on our website for more information about the day's online entertainment. Due to last-minute changes to the football schedule, we’ve moved the blood drive to two locations in Ann Arbor: the Kensington Hotel near Briarwood Mall and the Graduate Ann Arbor downtown.

Blood donors are encouraged to donate blood at the biggest blood drive in Southeast Michigan. Blood donations will count towards the Blood Battle competition against OSU. Attendees also have the opportunity to join the organ donor registry or be screened as a bone marrow donor. There will be virtual entertainment, activities, giveaways, special guests, and more throughout the day. More information coming soon.



Make an appointment to donate blood at redcrossblood.org using sponsor code "goblue". For information about the Red Cross’ safety protocols during the pandemic, click here(link is external).

Can't make it to Be a Hero? Schedule a blood drive appointment between 10/28/2020 and 11/25/2020 to help us beat OSU in the annual Blood Battle competition! Visit www.redcrossblood.org(link is external) and enter promo code "goblue."



Interested in volunteering at Be a Hero? Click here to sign up!(link is external)

Interested in sharing your donation/transplant story at the event? Contact Megan Podschlne at mpodschl@med.umich(link sends e-mail).edu(link sends e-mail) with a brief synopsis.

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Other Wed, 07 Oct 2020 16:56:24 -0400 2020-11-01T08:00:00-05:00 2020-11-01T17:00:00-05:00 Wolverines for Life Other Be a Hero 2020 flyer
Bioethics Discussion: Democracy (November 10, 2020 5:00pm) https://events.umich.edu/event/58831 58831-14563723@events.umich.edu Event Begins: Tuesday, November 10, 2020 5:00pm
Location: Lurie Biomedical Engineering
Organized By: The Bioethics Discussion Group

A discussion we will choose to have.

A few readings to consider on the matter:
––Bioethics and Democracy
––Bioethics and Populism: How Should Our Field Respond?
––Crowdsourcing in medical research: concepts and applications
––How Democracy Can Inform Consent: Cases of the Internet and Bioethics

For more information and/or to receive a copy of the readings visit http://belmont.bme.umich.edu/bioethics-discussion-group/discussions/050-democracy/.

––

While people are still allowed on campus, discussions will be held on the front lawn of Lurie Biomedical Engineering building. Participants will be asked to enter the area via a “welcome desk” where there will be hand sanitizer, wipes, etc. Participants will be masked, at least 12 feet from one another, and speaking through megaphones with one another. In accordance with public health mandates and guidance, participation will be limited to 20 individuals who sign up to participate ahead of time.

Sign up here: https://belmont.bme.umich.edu/ask-your-questions-to-ponder/

––
Together, we can read the blog (and probably do much more than that): https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Tue, 10 Nov 2020 16:24:01 -0500 2020-11-10T17:00:00-05:00 2020-11-10T18:30:00-05:00 Lurie Biomedical Engineering The Bioethics Discussion Group Lecture / Discussion Image 050. Democracy
A New Perspective on Amelogenesis and Dental Diagnoses (November 12, 2020 12:00pm) https://events.umich.edu/event/79191 79191-20225570@events.umich.edu Event Begins: Thursday, November 12, 2020 12:00pm
Location: Off Campus Location
Organized By: Office of Research School of Dentistry

James P. Simmer, DDS, PhD Professor of Dentistry
Biologic and Materials Sciences & Prosthodontics
University of Michigan School of Dentistry

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Lecture / Discussion Wed, 04 Nov 2020 15:24:08 -0500 2020-11-12T12:00:00-05:00 2020-11-12T13:00:00-05:00 Off Campus Location Office of Research School of Dentistry Lecture / Discussion Simmer
Reflections on Learning to Improve: Foundational Ideas, Observations from Practice, and Building a Field (November 12, 2020 12:00pm) https://events.umich.edu/event/78908 78908-20152763@events.umich.edu Event Begins: Thursday, November 12, 2020 12:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

While the LHS Collaboratory is typically focused on learning health, learning systems actually have very broad applicability. Moreover, there has been a strong interest in the Collaboratory from the education community which is also focused on learning systems.

A thought leader in this area, Anthony S. Bryk, President of the Carnegie Foundation for the Advancement of Teaching, will be speaking about a set of critical observations acquired in the course of his own efforts to improve how large complex educational systems work.

Discussants:

Elizabeth Birr Moje, Dean,
George Herbert Mead Collegiate Professor of Education,
and Arthur F. Thurnau Professor School of Education
Faculty Associate in the Institute for Social Research; Latino/a
Studies; and the Joint Program in English & Education
University of Michigan

Caren M. Stalburg, MD, MA
Collaborative Lead for Education
Associate Professor of Learning Health Sciences
Associate Professor of Obstetrics and Gynecology
Director of HILS Online Masters
University of Michigan

Moderator:

Donald J. Peurach, PhD
Professor
University of Michigan School of Education
Senior Fellow, Carnegie Foundation for the Advancement of
Teaching

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Lecture / Discussion Mon, 26 Oct 2020 12:41:04 -0400 2020-11-12T12:00:00-05:00 2020-11-12T13:30:00-05:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion Collaboratory logo
MedChem Seminar-“From DNA to natural products through genetics” (November 12, 2020 4:00pm) https://events.umich.edu/event/79280 79280-20264783@events.umich.edu Event Begins: Thursday, November 12, 2020 4:00pm
Location: Off Campus Location
Organized By: Department of Medicinal Chemistry

Please join us for a zoom remote seminar presented by Alessandra Eustaquio, PhD, Assistant Professor, College of Pharmacy, Department of Medicinal Chemistry and Pharmacognosy and Center for Pharmaceutical Biotechnology; University of Illinois, Chicago (UIC).

Please visit the department seminar page for the zoom link to the seminar.

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Livestream / Virtual Mon, 09 Nov 2020 12:43:59 -0500 2020-11-12T16:00:00-05:00 2020-11-12T17:00:00-05:00 Off Campus Location Department of Medicinal Chemistry Livestream / Virtual College of Pharmacy
RNA Seminar featuring: Michelle Hastings, Professor, Rosalind Franklin University of Medicine and Science (November 16, 2020 4:00pm) https://events.umich.edu/event/75868 75868-19615934@events.umich.edu Event Begins: Monday, November 16, 2020 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

https://umich.zoom.us/webinar/register/WN_VWX5SY6lSiaNyh5Weh8cHw

Michelle L. Hastings, PhD
Professor, Cell Biology and Anatomy
Director, Center for Genetic Diseases
Rosalind Franklin University of Medicine and Science

ABSTRACT: Antisense oligonucleotides (ASOs) have proven to be an effective therapeutic platform for the treatment of disease. These short, single-stranded, modified nucleotides function by base-pairing with the complementary sequence of an RNA and modulating gene expression in a manner that is dependent on the ASO design and targeting site. We have used ASOs to normalize aberrant gene expression associated with a number of diseases of the nervous system including Alzheimer’s and Parkinson’s disease and Usher syndrome. One of our approaches is under development for the treatment of CLN3 Batten disease, a fatal, pediatric lysosomal storage disease caused by mutations in a gene encoding the lysosomal membrane protein CLN3. The most common mutation associated with CLN3 Batten is a deletion of exons 7 and 8 (CLN3Δex78), which disrupts the mRNA open reading frame by creating a premature termination codon that results in the production of a truncated protein. We devised a therapeutic strategy for treating CLN3 Batten Disease using an ASO that basepairs to CLN3 pre-mRNA and alters splicing to correct the open reading frame of the mutated transcript. Treatment of CLN3Δex78 neonatal mice by intracerebroventricular injection of the ASO resulted in the desired splicing effect throughout the central nervous system, improved motor deficits associated with the disease in mice, reduced histopathological features of the disease in the brain and extended life in a severe mouse model of the disease. Our results demonstrate that ASO-mediated reading frame correction is a promising therapeutic approach for CLN3 Batten disease.

KEYWORDS: pre-mRNA splicing, Antisense oligonucleotides, Usher syndrome, Batten Disease, lysosomal storage diseases

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Lecture / Discussion Wed, 07 Oct 2020 09:31:00 -0400 2020-11-16T16:00:00-05:00 2020-11-16T17:00:00-05:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion photo
Chemosensory pathways involved in periodontitis and odontogenic pain (November 19, 2020 12:00pm) https://events.umich.edu/event/79190 79190-20225569@events.umich.edu Event Begins: Thursday, November 19, 2020 12:00pm
Location: Off Campus Location
Organized By: Office of Research School of Dentistry

Marco Tizzano, PhD
Assistant Member, Monell Chemical Senses Center
Adjunct Assistant Professor, Basic & Translational Sciences - Penn Dental Medicine

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Lecture / Discussion Wed, 04 Nov 2020 15:19:42 -0500 2020-11-19T12:00:00-05:00 2020-11-19T13:00:00-05:00 Off Campus Location Office of Research School of Dentistry Lecture / Discussion Tizzano
Where Do We Go From Here: Body Politics & Movement Towards Racial Empowerment (November 19, 2020 12:00pm) https://events.umich.edu/event/79333 79333-20272796@events.umich.edu Event Begins: Thursday, November 19, 2020 12:00pm
Location: Off Campus Location
Organized By: School of Kinesiology

A virtual panel discussion sponsored by the University of Michigan Health Sciences units, hosted by the School of Kinesiology, and featuring:

Vanessa Barrow, DPM
Podiatrist & Owner, Sole Aesthetic, LLC
Specialization: Aesthetic and regenerative medicine of the foot and ankle

Neha Gothe, PhD
Assistant Professor of Kinesiology & Community Health, University of Illinois at Urbana-Champaign
Research: Bio-psycho-social health benefits of physical activity across the lifespan; yoga as a means to improve health and quality of life

Samuel R. Hodge, PhD
Professor of Kinesiology, Ohio State University
Research: Intersection of diversity, disability, and social justice in education and sport

NiCole R. Keith, PhD, FACSM
Professor of Kinesiology & Associate Dean, Indiana University School of Health & Human Sciences
President, American College of Sports Medicine
Research: Community-based participatory research, physical activity, and health equity

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Lecture / Discussion Tue, 10 Nov 2020 17:05:27 -0500 2020-11-19T12:00:00-05:00 2020-11-19T13:00:00-05:00 Off Campus Location School of Kinesiology Lecture / Discussion University of Michigan Health Sciences present Where Do We Go From Here: Body Politics and Movement Towards Racial Empowerment
CSCS Seminar | Developing a systematic approach to modulate the emergence of consciousness from pharmacologically-and pathologically induced unconsciousness (December 1, 2020 11:30am) https://events.umich.edu/event/76220 76220-19677552@events.umich.edu Event Begins: Tuesday, December 1, 2020 11:30am
Location: Off Campus Location
Organized By: The Center for the Study of Complex Systems

ZOOM MEETING LINK: myumi.ch/v2ZYv

Re-scheduled from earlier this fall.

ABSTRACT:
Why is it so difficult to develop a systematic approach to modulate the recovery of consciousness from pharmacologically and pathologically induced unconsciousness? Three things are required to develop a systematic approach; a reliable neural activity that corresponds to consciousness, a reliable brain stimulation to induce the target neural activity, and a mechanism to guarantee the induced neural activity results in consciousness. However, no single neural activity or a mechanism has been identified yet as a neural correlate of consciousness, suggesting that consciousness might emerge through complex interactions of spatially and temporally distributed brain functions. Accumulating evidence from computational model and empirical studies suggest that brain criticality – a balanced state between order and disorder, stability and instability, incoherent and synchronized connectivity at a global network level, is a necessary condition for the emergence of consciousness. Thus, in our research project, we hypothesized that with modulating brain network criticality, we may be able to control the state transition during the loss and recovery of consciousness in general anesthesia and coma. In this talk, I will introduce our current project that aims to develop a systematic method to precisely evaluate a brain state in altered states of consciousness and to control the emergence from unconsciousness, which is based on highly advanced methods in physics, network science, and neurobiology of consciousness.

Please join us 15 minutes before and after the seminar for a social coffee hangout. Put your speakers and video on and say hi to old friends or go to the 'lounge' and chat with an acquaintance

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Livestream / Virtual Mon, 23 Nov 2020 16:33:23 -0500 2020-12-01T11:30:00-05:00 2020-12-01T13:00:00-05:00 Off Campus Location The Center for the Study of Complex Systems Livestream / Virtual Photo of UnCheol Lee
RNA Seminar featuring: John Mattick, University of New South Wales, Sydney, Australia (December 7, 2020 5:00pm) https://events.umich.edu/event/75816 75816-19608031@events.umich.edu Event Begins: Monday, December 7, 2020 5:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_fCIiMkveTdq3D9-PKFLm6Q

ABSTRACT: The genomic programming of the development of complex organisms appears to have been misunderstood. The human genome contains just ~20,000 protein-coding genes, similar in number and with largely orthologous functions as those in other animals, including simple nematodes with only 1,000 somatic cells. By contrast, the extent of non-protein-coding DNA increases with increasing developmental complexity, reaching 98.8% in humans. Moreover, it is now clear that the majority of the genome is not junk but is differentially and dynamically transcribed to produce not only mRNAs but also tens if not hundreds of thousands of short and long non-protein-coding RNAs that show specific expression patterns and subcellular locations. Many of these noncoding RNAs have evolved rapidly under positive selection for adaptive radiation, and many have been shown to have important roles in development, brain function, cancer and other diseases. They function at many different levels of gene expression and cell biology, including translational control, formation of subcellular (phase-separated) domains, and guidance of the epigenetic processes and chromatin dynamics that underpin development, brain function and physiological adaptation, with plasticity enabled by RNA editing, RNA modification and retrotransposon mobilization. These discoveries mean that the assumption that combinatorial control by transcription factors and other regulatory proteins is sufficient to account for human ontogeny is incorrect, as are the circular assumptions about the neutral evolution of the genome. The challenge now is to determine the structure-function relationships of these RNAs and their mechanisms of action, as well as their place in the decisional hierarchies that control human development, physiology, learning and susceptibility to disorders.

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Lecture / Discussion Tue, 03 Nov 2020 16:51:46 -0500 2020-12-07T17:00:00-05:00 2020-12-07T18:00:00-05:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion photo
RNA Seminar featuring: Narry Kim, Seoul National University (December 14, 2020 4:00pm) https://events.umich.edu/event/75818 75818-19608034@events.umich.edu Event Begins: Monday, December 14, 2020 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

ZOOM REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_c9BFJM9dRGKn1WFF4L_wLg

ABSTRACT: Viruses rely heavily on RNA binding proteins for their success as pathogens. In this presentation, I will first talk about RNA tail modification which impacts viral and cellular gene expression. We found that TENT4 enzymes extend poly(A) tail of mRNAs with ‘mixed tails’ to delay deadenylation and stabilize the RNAs. Hepatitis B virus and human cytomegalovirus hijack this mechanism to efficiently stabilize their own RNAs. In the later part of my presentation, I will discuss our recent work on SARS-CoV-2. To delineate the viral transcriptomic architecture and provide a high-resolution map of SARS-CoV-2, we performed deep sequencing of infected cells. Our data define the canonical transcripts and noncanonical transcripts encoding unknown ORFs. More recently, we have also performed proteomic analyses of the SARS-CoV-2 ribonucleoprotein complex. We identify many proteins that directly interact with viral RNAs and modulate viral growth. Functional investigation of the viral transcripts and host proteins discovered in this study will open new directions to the research efforts to elucidate the life cycle and pathogenicity of SARS-CoV-2.

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Lecture / Discussion Wed, 02 Dec 2020 12:55:41 -0500 2020-12-14T16:00:00-05:00 2020-12-14T17:00:00-05:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Narry Kim, Seoul National University
MIDAS & Owkin Federated Learning in Biomedical Research Workshop (January 14, 2021 10:00am) https://events.umich.edu/event/80139 80139-20566722@events.umich.edu Event Begins: Thursday, January 14, 2021 10:00am
Location: Off Campus Location
Organized By: Michigan Institute for Data Science

Objective: Cultivating research collaboration, joint grants and connecting the UM researchers to the right organisations. Supports Owkin expansion of our presence in North America and facilitates collaborations with PIs at UM. A great introduction to what Owkin does to UM.

Introduction Owkin & Scientific Overview of the Sessions — Patrick Sin-Chan, Partnerships Manager – Owkin
Session 1: Methodology and Data Science
Learning From Others Without Sacrificing Privacy: Application of Federated Machine Learning to Mobile Health Data
Presenter: Ambuj Tewari, Associate Professor, Statistics
Privacy Preserving Federated Learning Platform: from Design to Deployment in Real World Use Cases
Presenter: Camille Marini
Accelerating Machine Learning with Multi-Armed Bandit
Barzan Mozafari, Associate Professor, Computer Science and Engineering
Siloed Federated Learning for Multi-Centric Histopathology Datasets
Presenter: Mathieu Andreux
20 mins Panel Discussion (MIDAS Moderator- Kayvan Najarian, Professor, Computational Medicine and Bioinformatics)
Session 2: Biotech/medical
Covid-19 Severity Analysis with CT Scans and Machine Learning
Presenter: Simon Jégou
Linking Single-cell Molecular States with Phenotypes Using Machine Learning
Presenter: Josh Welch, Assistant Professor, Computational Medicine and Bioinformatics
HE2RNA: a Deep Learning Model to Predict RNA-Seq Expression of Tumors from Whole Slide Images
Presenter: Alberto Romagnoni
Using Large-scale Pharmacogenomic Databases to Predict Drug Effectiveness
Presenter: Johann Gagnon-Bartsch, Assistant Professor, Statistics
20 mins Panel discussion (Owkin Moderator: Patrick Sin-Chan)

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Workshop / Seminar Thu, 17 Dec 2020 19:36:31 -0500 2021-01-14T10:00:00-05:00 2021-01-14T14:30:00-05:00 Off Campus Location Michigan Institute for Data Science Workshop / Seminar Okwin
U-M Health Sciences 2021 MLK Keynote (January 18, 2021 12:00pm) https://events.umich.edu/event/79757 79757-20484063@events.umich.edu Event Begins: Monday, January 18, 2021 12:00pm
Location: Off Campus Location
Organized By: School of Kinesiology

Bodies represent the sites of socially constructed differences and power relations. As such, the personal is political, and bodies are subject to political interpretations. Body politics based on racial (and/or ethnic) ascriptions (along with other intersecting elements such as sex, gender, sexuality, age, social class, ability, etc.) have adversely affected the overall health and wellness of bodies of Color in general, and Black bodies in particular - impacting their abilities, opportunities, access (inclusion/exclusion), care/treatment, and the overall nature of their lived experiences. Consequently, racialed body politics have contributed to an array of health disparities being more pronounced in communities of Color. However, movement offers a variety of health benefits and is therefore, a source of empowerment for racially politicized bodies.

This event will feature a keynote presentation by Dr. Monique Butler, U-M Kinesiology alumna and Chief Medical Officer for HCA Healthcare North Florida Division. She will address the theme "Where Do We Go From Here: Body Politics and Movement Towards Racial Empowerment."

This event is sponsored by the U-M Health Sciences units and hosted by the School of Kinesiology.

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Lecture / Discussion Tue, 05 Jan 2021 16:27:06 -0500 2021-01-18T12:00:00-05:00 2021-01-18T13:30:00-05:00 Off Campus Location School of Kinesiology Lecture / Discussion U-M Health Sciences 2021 MLK Keynote - Where Do We Go From Here: Body Politics and Movement Towards Racial Empowerment - with Dr. Monique Butler, MD
Modeling basal cell carcinoma: stem cell origin, drug response and tumor dormancy (January 18, 2021 1:00pm) https://events.umich.edu/event/80883 80883-20816992@events.umich.edu Event Begins: Monday, January 18, 2021 1:00pm
Location: Off Campus Location
Organized By: Office of Research School of Dentistry

Associate Professor of Dermatology and Associate Professor of Cell and Development Biology, University of Michigan Medical School

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Workshop / Seminar Mon, 18 Jan 2021 13:44:33 -0500 2021-01-18T13:00:00-05:00 2021-01-18T14:00:00-05:00 Off Campus Location Office of Research School of Dentistry Workshop / Seminar Sunny Wong
LHS Collaboratory (January 21, 2021 11:30am) https://events.umich.edu/event/80293 80293-20688136@events.umich.edu Event Begins: Thursday, January 21, 2021 11:30am
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

The LHS Collaboratory presents Rachel Richesson, PhD, MPH, MS, FACMI, Professor of Learning Health Sciences, Department of Learning Health Sciences at the University of Michigan in a virtual event on 1/21/2021 from 11:30 am to 1:00 pm ET.

Professor Richesson's talk, "Data Standards and Learning Health Systems –Challenges and Opportunities," will be followed by an audience Q&A. Questions are also encouraged prior to the event.

Please send questions to LHSCollaboratory-info@umich.edu.

Registration in advance at: https://umich-health.zoom.us/webinar/register/WN_HytRsYwITc6oOGRj0F_MOA

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Livestream / Virtual Sat, 02 Jan 2021 10:24:08 -0500 2021-01-21T11:30:00-05:00 2021-01-21T13:00:00-05:00 Off Campus Location Department of Learning Health Sciences Livestream / Virtual LHS Collaboratory logo
RNA Seminar featuring: Elena Conti, Max Planck Institute of Biochemistry (January 25, 2021 9:00am) https://events.umich.edu/event/75826 75826-19613920@events.umich.edu Event Begins: Monday, January 25, 2021 9:00am
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

KEYWORDS: molecular mechanisms, RNA, ribosome, biochemistry, cryo-EM, X-ray crystallography

ABSTRACT: All RNAs in eukaryotic cells are eventually degraded. The RNA exosome is a conserved macromolecular machine that degrades a vast number and variety of RNAs. Exosome-mediated RNA degradation leads to the complete elimination of nuclear and cytoplasmic transcripts in turnover and quality control pathways, and to the partial trimming of RNA precursors in nuclear processing pathways. How the exosome combines specificity and versatility to either eliminate or process RNAs has been a long-standing question.

ZOOM REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_IjnWw1UcRkW8zcDeuAM2tQ

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Lecture / Discussion Mon, 04 Jan 2021 10:08:44 -0500 2021-01-25T09:00:00-05:00 2021-01-25T10:00:00-05:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Elena Conti, Max Planck Institute of Biochemistry
RNA Seminar featuring: Jeff Twiss, MD, PhD, SmartState Chair in Childhood Neurotherapeutics, Professor of Biological Sciences, University of South Carolina (February 1, 2021 4:00pm) https://events.umich.edu/event/75813 75813-19608028@events.umich.edu Event Begins: Monday, February 1, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_Rss4i-7WTwyf8m8ogCPXEQ

Abstract: Neurons are extremely polarized cells with axonal and dendritic processes extending 100 to 1000 fold longer or more than the cell body diameter. Our lab has been interested in how axons grow to such great distances and how they respond to injury. mRNAs are transported into axons, with their localized translation providing the axon with autonomy to respond to different stimuli by modifying their local proteome. Transport, translation, and stability of axonal mRNAs is driven by interactions with RNA binding proteins and different signaling cascades. I will focus on recent work that gives insight into how specificity of these mechanisms is driven for different cohorts of axonal mRNAs.

Keywords - Neuron, Axon, RNA transport, Translational regulation

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Lecture / Discussion Fri, 15 Jan 2021 14:13:00 -0500 2021-02-01T16:00:00-05:00 2021-02-01T17:00:00-05:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Jeff Twiss, University of South Carolina
Abstracts Due for 2021 Health Professions Education Day (February 2, 2021 1:00am) https://events.umich.edu/event/80496 80496-20730277@events.umich.edu Event Begins: Tuesday, February 2, 2021 1:00am
Location: Off Campus Location
Organized By: Center for Interprofessional Education

Join in the annual #UMHPEDAY, a virtual event to inspire future & current health professionals across @UMich to research, network & collaborate. Faculty, students, researchers and practitioners can submit poster abstracts by Feb. 2.

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Conference / Symposium Thu, 07 Jan 2021 15:09:19 -0500 2021-02-02T01:00:00-05:00 2021-02-02T23:00:00-05:00 Off Campus Location Center for Interprofessional Education Conference / Symposium Submit HPE Day abstracts by Feb. 2
Oral Health Sciences Seminar Series (February 11, 2021 12:00pm) https://events.umich.edu/event/81688 81688-20943436@events.umich.edu Event Begins: Thursday, February 11, 2021 12:00pm
Location: Off Campus Location
Organized By: Office of Research School of Dentistry

Lola Eniola-Adefeso, Ph.D.
University Diversity and Social Transformation Professor of Chemical Engineering
Vice-Chair for Graduate Studies in Chemical Engineering
Professor of Biomedical Engineering
Professor of Macromolecular Science and Engineering
Miller Faculty Scholar
Director, Cell Adhesion and Drug Delivery Lab
Associate Director, NIH Cellular Biotechnology Training Grant
University of Michigan

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Presentation Mon, 31 Jan 2022 10:25:38 -0500 2021-02-11T12:00:00-05:00 2021-02-11T13:00:00-05:00 Off Campus Location Office of Research School of Dentistry Presentation Lola Eniola-Adefeso, Ph.D.
RNA Seminar featuring: Karla Neugebauer, Yale University School of Medicine (February 15, 2021 4:00pm) https://events.umich.edu/event/78295 78295-20004839@events.umich.edu Event Begins: Monday, February 15, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

ZOOM REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_aZggyZ0yQcSPcJrsHloXjQ

ABSTRACT: My lab is interested in the coordination between transcription, RNA processing and nuclear organization that governs gene expression. We have established experimental systems in budding yeast, zebrafish embryos, and mammalian tissue culture cells to explore transcription and splicing regulation in a variety of biological contexts and with a diversity of tools, from imaging to genome-wide approaches. Our observations have provided novel insights into transcription and splicing mechanisms as well as principles of cellular organization that facilitate efficient gene expression. In this talk, I will be discussing rapid co-transcriptional splicing during erythropoiesis and how Cajal bodies assemble to ensure a steady supply of spliceosomal components.

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Lecture / Discussion Tue, 02 Feb 2021 16:32:41 -0500 2021-02-15T16:00:00-05:00 2021-02-15T17:00:00-05:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Prof. Karla Neugebauer, Ph.D.
Looking Ahead at Healthcare: What to Expect From The New Administration (February 18, 2021 12:00pm) https://events.umich.edu/event/82045 82045-21012683@events.umich.edu Event Begins: Thursday, February 18, 2021 12:00pm
Location: Off Campus Location
Organized By: Michigan Ross

We are excited to be hosting our third event in The Business of Healthcare webinar series on Thursday, February 18. Join Tom Buchmueller, Ross School of Business, as he moderates a conversation with panelists Katie Keith and Joanne Kenen on Looking Ahead at Healthcare: What to Expect From The New Administration.

February 18, 2021
12:00pm - 1:15pm EST

Tom Buchmueller, PhD
Waldo O. Hildebrand Professor of Risk Management and Insurance; Professor of Business Economics and Public Policy, Michigan Ross

Katie Keith, J.D., M.P.H.
Principal, Keith Policy Solutions LLC; Adjunct Professor of Law, Georgetown University Law Center

Joanne Kenen
Editor At Large, Health Care at POLITICO

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Lecture / Discussion Fri, 12 Feb 2021 11:46:11 -0500 2021-02-18T12:00:00-05:00 2021-02-18T13:15:00-05:00 Off Campus Location Michigan Ross Lecture / Discussion
Powering through Uncertainty (February 18, 2021 1:00pm) https://events.umich.edu/event/80885 80885-20816994@events.umich.edu Event Begins: Thursday, February 18, 2021 1:00pm
Location: Off Campus Location
Organized By: Office of Research School of Dentistry

Platform Architect, Intel & Founder, Timouns

Dr. Simon is a biomedical engineer, author and inventor who graduated from the University of Michigan Biomedical Engineering PhD program and was a School of Dentistry T32-TEAM Training Grant trainee. Her keynote seminar titled "Powering through Uncertainty" will encourage and inspire our students, faculty and staff as we strive to meet our mission of advancing health through education, service, research and discovery.

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Livestream / Virtual Mon, 18 Jan 2021 14:05:48 -0500 2021-02-18T13:00:00-05:00 2021-02-18T14:00:00-05:00 Off Campus Location Office of Research School of Dentistry Livestream / Virtual Keynote Speaker, Arlyne Simon
LHS Collaboratory- February session (February 23, 2021 12:00pm) https://events.umich.edu/event/81035 81035-20838675@events.umich.edu Event Begins: Tuesday, February 23, 2021 12:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

The keynote presentation (12:00 pm-1:15 pm ET) will be followed by breakout sessions (1:15 pm-2:15 pm ET) on topics presented by the UM faculty and guests.
Zoom links to the individual breakout sessions are listed below.

Keynote speaker: Dr. Bernardo Mariano, Jr.
Topic: Digital Transformation in Healthcare for a Diverse World
Director of Digital Health & Innovation
Chief Information Officer (CIO)
World Health Organization (WHO)

Remarks:
Laurie McCauley, DDS, MS, PhD
Dean, William K and Mary Anne Najjar Professor of Periodontics
University of Michigan School of Dentistry


Breakout sessions from 1:15 pm-2:15 pm (ET)

Breakout Session #1 LHS and Pain
Zoom link: https://umich.zoom.us/j/99190944947

Topic: Integrating Diverse Health Ecosystems for
Optimal Pain Treatment, Education and Research
Alex F. DaSilva, DDS, DMedSc
University of Michigan School of Dentistry

Perspective: Data De‐Identification and Clinical Decision Support
Ivo Dinov, Ph.D.
Department of Health Behavior and Biological Sciences
University of Michigan


Breakout Session #2 LHS and Caries Risk
Zoom link: https://umich.zoom.us/j/97070468943

Topic: Caries Risk Prediction Models
Margherita Fontana, DDS, PhD
University of Michigan School of Dentistry

Perspective: LHS and Evidence-based Clinical Practice
Alonso Carrasco-Labra, DDS, MSc, PhD
Department of Evidence Synthesis and Translation Research
American Dental Association

Breakout Session #3 LHS and Opioids
Zoom link: https://umich.zoom.us/j/96029888703


Topic: Iteratively Learning about Dental Opioid Prescribing
Romesh Nalliah, BDS, MHCM
University of Michigan School of Dentistry

Perspective: Precision Health in Opioid Management
Chad Brummett, M.D.
University of Michigan Department of Anesthesiology

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Lecture / Discussion Thu, 21 Jan 2021 09:43:32 -0500 2021-02-23T12:00:00-05:00 2021-02-23T14:15:00-05:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion LHS Collaboratory Logo
RNA Seminar featuring: Melissa Moore, Moderna Therapeutics (March 3, 2021 4:00pm) https://events.umich.edu/event/81265 81265-20879904@events.umich.edu Event Begins: Wednesday, March 3, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

**Please register here for March 3rd seminar: https://umich.zoom.us/webinar/register/WN_l0kt_NjpRh-f33LJj7KGpA

Dr. Moore will address scientists and non-scientists, and will take live questions.

In her role as Chief Scientific Officer, Platform Research, Dr. Melissa Moore is responsible for leading mRNA biology, delivery and computation science research at Moderna. She joined Moderna in 2016 from the University of Massachusetts Medical School, where she served as Professor of Biochemistry & Molecular Pharmacology, Eleanor Eustis Farrington Chair in Cancer Research and a long-time Investigator at the Howard Hughes Medical Institute (HHMI). Dr. Moore was also a founding Co-Director of the RNA Therapeutics Institute (RTI) at UMassMed, and was instrumental in creating the Massachusetts Therapeutic and Entrepreneurship Realization initiative (MassTERi), a faculty-led program intended to facilitate the translation of UMMS discoveries into drugs, products, technologies and companies. Dr. Moore is an elected member of the National Academy of Sciences (2017) and a Fellow of the American Academy of Arts and Sciences (2019).

Dr. Moore holds a B.S. in Chemistry and Biology from the College of William and Mary, and a Ph.D. in Biological Chemistry from MIT, where she specialized in enzymology under Prof. Christopher T. Walsh. She began working on RNA metabolism during her postdoctoral training with Phillip A. Sharp at MIT. During her 23 years as a faculty member, first at Brandeis and then at UMassMed, her research encompassed a broad array of topics related to the roles of RNA and RNA-protein (RNP) complexes in gene expression, and touched on many human diseases including cancer, neurodegeneration, and preeclampsia.

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Lecture / Discussion Wed, 10 Feb 2021 19:47:49 -0500 2021-03-03T16:00:00-05:00 2021-03-03T17:00:00-05:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Melissa Moore, Ph.D., Moderna Therapeutics
Bioethics Discussion: Infection (March 9, 2021 7:00pm) https://events.umich.edu/event/58838 58838-14563730@events.umich.edu Event Begins: Tuesday, March 9, 2021 7:00pm
Location: Off Campus Location
Organized By: The Bioethics Discussion Group

A discussion spreading to others.

Join us at: https://umich.zoom.us/j/99926126455.

A few readings to consider:
––Evidence and Effectiveness in Decision-Making for Quarantine
––The 1918 Influenza Pandemic: Insights for the 21st Century
––From SARS to Ebola: Legal and Ethical Considerations for Modern Quarantine
––Responding to the COVID-19 pandemic: Ethical considerations for conducting controlled human infection studies

For more information and/or to receive a copy of the readings visit http://belmont.bme.umich.edu/bioethics-discussion-group/discussions/057-infection/.

––
Feel free to stop by the website, not even the blog is viral: https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Fri, 08 Jan 2021 09:40:23 -0500 2021-03-09T19:00:00-05:00 2021-03-09T20:30:00-05:00 Off Campus Location The Bioethics Discussion Group Lecture / Discussion Infection
RNA Seminar featuring: James Nuñez, HHMI Hanna Gray Fellow, University of California, San Francisco (March 15, 2021 4:00pm) https://events.umich.edu/event/81286 81286-20881887@events.umich.edu Event Begins: Monday, March 15, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_f8wC8rrJQzuhYzTEXoW69Q


ABSTRACT
General approaches for heritably altering gene expression would enable many discovery and therapeutic efforts. I will present CRISPRoff— a programmable epigenetic memory writer consisting of a single dead Cas9 fusion protein that establishes DNA methylation and repressive histone modifications to turn off transcription. Transient CRISPRoff expression initiates highly specific DNA methylation and gene repression that is maintained through cell division and differentiation of stem cells to neurons. Pairing CRISPRoff with genome-wide screens and analysis of chromatin marks enabled us to explore the rules for heritable silencing. We identify sgRNAs capable of silencing the large majority of genes including those lacking canonical CpG islands (CGIs) and reveal a wide targeting window extending beyond annotated CGIs. Our finding that targeted DNA methylation outside of CGIs leads to memorized gene silencing expands the canonical model of methylation-based silencing and broadly enables diverse applications including genome-wide screens, multiplexed cell engineering, enhancer silencing, and mechanistic exploration of epigenetic inheritance.

KEYWORDS: CRISPR, transcription, epigenetics
Flyer in PDF: https://rna.umich.edu/wp-content/uploads/2021/02/Seminar-Flyer-03152021-Nunez.pdf

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Lecture / Discussion Thu, 18 Feb 2021 09:21:31 -0500 2021-03-15T16:00:00-04:00 2021-03-15T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion James Nunez, Ph.D. UCSF
Where Do We Go From Here: Body Politics & Movement Towards Racial Empowerment (March 24, 2021 12:00pm) https://events.umich.edu/event/82828 82828-21179596@events.umich.edu Event Begins: Wednesday, March 24, 2021 12:00pm
Location: Off Campus Location
Organized By: School of Kinesiology

Please join us for the last event in our series addressing the theme: "Where Do We Go From Here: Body Politics and Movement Towards Racial Empowerment."

This event will consist of a panel featuring scholars and medical, mental health, and fitness experts discussing movement, and physical and mental wellness/well-being as ways of combatting the body politics of racism. The event will include panelists’ demonstrations and audience participation.

If you'd like to join along with the Afrobeats dance demonstration (and we hope you do), please wear comfortable clothes and use a space where you have room to move. All ages and abilities are welcome; no experience needed!

--Abigail Eiler, LMSW, MSW, QMHP: Clinical Assistant Professor, U-M School of Social Work; Director, Athletics Counseling, U-M Athletics; Chair, Mental Health & Wellness Cabinet, Big Ten Conference

--Chiamaka Ukachukwu, MS: PhD Candidate (Specializing in Cardiovascular Electrophysiology), U-M Department of Pharmacology; Afrobeats Dance Instructor, U-M Recreational Sports

--Dr. Kamaria Washington, DPT: Physical Therapist (Specializing in Pelvic Floor Concerns), Therapeutic Associates Bethany Physical Therapy (Portland, OR)

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Well-being Wed, 17 Mar 2021 17:58:46 -0400 2021-03-24T12:00:00-04:00 2021-03-24T13:30:00-04:00 Off Campus Location School of Kinesiology Well-being U-M Health Sciences - Where Do We Go From Here: Body Politics & Movement Towards Racial Empowerment
Designing for Impact in Global Health (March 24, 2021 5:00pm) https://events.umich.edu/event/82821 82821-21179589@events.umich.edu Event Begins: Wednesday, March 24, 2021 5:00pm
Location: Off Campus Location
Organized By: Center for Global Health Equity

Please join us for the next seminar for the UM Center for Global Health Equity: Designing for Impact in Global Health.

Panelists include:
Kathleen Sienko, College of Engineering
Paul Clyde, William Davidson Institute
Rocky Oteng, School of Medicine
Kentaro Toyama, School of Information
Grace Burleson, College of Engineering
David Green, Social Entrepreneur
Jesse Austin-Breneman, College of Engineering

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Workshop / Seminar Fri, 05 Mar 2021 14:12:00 -0500 2021-03-24T17:00:00-04:00 2021-03-24T18:30:00-04:00 Off Campus Location Center for Global Health Equity Workshop / Seminar Panelists
5th Annual RNA Symposium, "Processing RNA" (March 25, 2021 11:00am) https://events.umich.edu/event/80161 80161-20572609@events.umich.edu Event Begins: Thursday, March 25, 2021 11:00am
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

FOR MORE DETAILS & ABSTRACTS VISIT: https://rna.umich.edu/2021-symposium/

Thursday, March 25, 2021
11:00 / Welcome
11:05 / KEYNOTE 1: Tracy Johnson, UCLA, “RNA Splicing, Chromatin Modification, and the Coordinated Control of Gene expression”
12:00 / Short break
12:10 / KEYNOTE 2: Kevin Weeks, UNC, “Structure-Based Discovery of New Functions in Large RNAs”
1:05 / Data Blitz: Cathy Smith, Daniel Peltier, Yan Zhang
1:35 / KEYNOTE 3: Feng Zhang, MIT, “Exploration of Biological Diversity to Discover Novel Molecular Technologies”
2:30 / Close Day 1

Friday, March 26, 2021
11:00 / Welcome
11:05 / KEYNOTE 4: Brenda Bass, University of Utah, “Distinguishing self and non-self dsRNA in vertebrates and invertebrates”
12:00 / Short break
12:10 / KEYNOTE 5: Christopher Lima, Sloan-Kettering Institute, “Mechanisms that target RNA for destruction”
1:05 / Data Blitz: Meredith Purchal, Adrien Chauvier, Shannon Wright
1:35 / Panel discussion with keynote speakers
2:30 / Close Day 2

Liveblogging by MiSciWriters! https://misciwriters.com/

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Lecture / Discussion Tue, 23 Mar 2021 15:03:26 -0400 2021-03-25T11:00:00-04:00 2021-03-25T14:30:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion 5th Annual RNA Symposium
LHS Collaboratory March Session (March 25, 2021 12:00pm) https://events.umich.edu/event/82008 82008-21006745@events.umich.edu Event Begins: Thursday, March 25, 2021 12:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Speakers Stefan Boes, PhD and Sarah Mantwill, PhD from the university of Lucerne will discuss the Swiss Learning Health System.

Promoting and supporting uptake of evidence and evidence-informed decision-making in health-systems related policy and practice is a challenge. In Switzerland, the need to address this matter has been increasingly emphasized by different actors in the health system. In particular, the lack of comprehensive coordination efforts in the field of health services research, and subsequent knowledge translation activities, has been stressed. In response, the Swiss Learning Health System (SLHS) was established as a nationwide project in 2017, currently involving 10 academic partner institutions. One of the overarching objectives of the SLHS is to bridge research, policy, and practice by providing an infrastructure that supports learning cycles by: continuously identifying issues relevant to the Swiss health system, systemizing relevant evidence, presenting potential courses of action, and revising and reshaping responses. Key features of learning cycles in the SLHS include the development of policy/evidence briefs that serve as a basis for stakeholder dialogues with actors from research, policy and practice. Issues that are identified to be further pursued are monitored for potential implementation and eventually evaluated to inform new learning cycles and to support continuous learning within the system.

Dr. Boes and Dr. Mantwill will provide an overview of the SLHS and its key features, as well as its capacity building efforts to train young researchers in the field of learning health systems, and the development of a centralized metadata repository in support of creating a sufficient large evidence basis to support learning cycles in the Swiss health system. Further, they will discuss lessons learned from the past and the newest developments of the SLHS in light of a second funding phase supported by the Swiss government.

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Livestream / Virtual Thu, 25 Feb 2021 23:57:27 -0500 2021-03-25T12:00:00-04:00 2021-03-25T13:30:00-04:00 Off Campus Location Department of Learning Health Sciences Livestream / Virtual LHS Collaboratory Logo
5th Annual RNA Symposium, "Processing RNA" (March 26, 2021 11:00am) https://events.umich.edu/event/80161 80161-20572610@events.umich.edu Event Begins: Friday, March 26, 2021 11:00am
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

FOR MORE DETAILS & ABSTRACTS VISIT: https://rna.umich.edu/2021-symposium/

Thursday, March 25, 2021
11:00 / Welcome
11:05 / KEYNOTE 1: Tracy Johnson, UCLA, “RNA Splicing, Chromatin Modification, and the Coordinated Control of Gene expression”
12:00 / Short break
12:10 / KEYNOTE 2: Kevin Weeks, UNC, “Structure-Based Discovery of New Functions in Large RNAs”
1:05 / Data Blitz: Cathy Smith, Daniel Peltier, Yan Zhang
1:35 / KEYNOTE 3: Feng Zhang, MIT, “Exploration of Biological Diversity to Discover Novel Molecular Technologies”
2:30 / Close Day 1

Friday, March 26, 2021
11:00 / Welcome
11:05 / KEYNOTE 4: Brenda Bass, University of Utah, “Distinguishing self and non-self dsRNA in vertebrates and invertebrates”
12:00 / Short break
12:10 / KEYNOTE 5: Christopher Lima, Sloan-Kettering Institute, “Mechanisms that target RNA for destruction”
1:05 / Data Blitz: Meredith Purchal, Adrien Chauvier, Shannon Wright
1:35 / Panel discussion with keynote speakers
2:30 / Close Day 2

Liveblogging by MiSciWriters! https://misciwriters.com/

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Lecture / Discussion Tue, 23 Mar 2021 15:03:26 -0400 2021-03-26T11:00:00-04:00 2021-03-26T14:30:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion 5th Annual RNA Symposium
RNA Seminar featuring: Natoya Peart, PhD, University of Pennsylvania (April 5, 2021 4:00pm) https://events.umich.edu/event/81288 81288-20881888@events.umich.edu Event Begins: Monday, April 5, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

Registration required: https://umich.zoom.us/webinar/register/WN_0lUfePb0Qdac-cQZDpeiEQ


KEYWORDS: Alternative splicing, RNAMap, Esrp1

ABSTRACT: Coordinated regulation of alternative splicing is essential to the establishment of cell identity. The Epithelial Splicing Regulatory Proteins (Esrps), ESRP1 and ESRP2, are highly conserved paralogous proteins required for organogenesis of multiple organ systems and compromised function of Esrps contributes to human diseases and pathologies. Esrps are robustly expressed in the epithelial cells of the epidermis, large and small intestines, salivary glands, stomach, and a variety of other tissues, where they are vital in promoting an epithelial splicing network. Although ESRP1 and ESRP2 share partial functional redundancy, ESRP1 appears to play a larger role in regulating gene expression.
Using a combination of enhanced immunoprecipitation coupled with high throughput sequencing (eCLIP) in the epithelial cells of mouse epidermis and RNA sequencing analysis of alterations in splicing and total gene expression that result from epidermal ablation of Esrp1 and Esrp2 we generate a map of Esrp1 binding to RNA. We show that ESRP1 regulates splicing primarily through direct binding in a position-dependent manner to either promote exon inclusion or skipping. In particular, we show that Esrp1 binding upstream of or withing alternatively spliced exons suppresses exon inclusion, whilst binding downstream of the non-constitutive exon promotes exon inclusion. In addition, we identified widespread binding of ESRP1 in 3’ and 5’ untranslated regions (UTRs) of genes enriched for epithelial cell function suggesting that it directly regulates post-transcriptional gene expression steps in addition to splicing.


If you are having difficulties registering, please contact Martina Jerant at mjerant@umich.edu

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Lecture / Discussion Mon, 08 Mar 2021 12:23:08 -0500 2021-04-05T16:00:00-04:00 2021-04-05T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Natoya Peart, PhD, University of Pennsylvania
RNA Seminar featuring: Jailson (Jay) Brito Querido, Ph.D. MRC Laboratory of Molecular Biology, Cambridge, UK (April 19, 2021 4:00pm) https://events.umich.edu/event/81408 81408-20893767@events.umich.edu Event Begins: Monday, April 19, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_78YYOhIhTbOBy2_JSdM7Wg

ABSTRACT: A key step in translational initiation is the recruitment of the 43S pre-initiation complex (43S PIC) by the cap-binding complex (eIF4F) at the 5´ end of mRNA. Eukaryotic initiation factors eIF1, eIF1A, eIF3, eIF5, and the ternary complex (TC) of eIF2–GTP–tRNAiMet bind to the 40S ribosomal subunit to form the 43S PIC. Once assembled, the 43S PIC is recruited to the cap-binding complex eIF4F at the 5´end of mRNA to form a 48S initiation complex (48S). The 48S then scans along the mRNA to locate a start codon. To understand the mechanisms involved, we determined the structure of a reconstituted human 48S using cryo-electron microscopy. The structure reveals insights into early events of translation initiation complex assembly. It reveals how eIF4F interacts with subunits of the eIF3 structural core near the mRNA exit channel in the 43S. The location of eIF4F is consistent with a slotting model of mRNA recruitment and suggests a “blind-region” that would preclude recognition of start sites upstream of the location of the P site at the point of recruitment.

KEYWORDS: mRNA, ribosome, eIF4F, eIF4A, translation

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Lecture / Discussion Tue, 13 Apr 2021 12:58:40 -0400 2021-04-19T16:00:00-04:00 2021-04-19T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Jailson (Jay) Brito Querido, Ph.D.
Bioethics Discussion: Abdication (April 20, 2021 7:00pm) https://events.umich.edu/event/58841 58841-14563735@events.umich.edu Event Begins: Tuesday, April 20, 2021 7:00pm
Location: Lurie Biomedical Engineering
Organized By: The Bioethics Discussion Group

A discussion on our renunciation.

Join us at: https://umich.zoom.us/j/99926126455

A few readings to consider:
––The Idea of Legitimate Authority in the Practice of Medicine
––Decentralization of health care systems and health outcomes: Evidence from a natural experiment
––Vox Populi or Abdication of Responsibility?: The Influence of the Irish Citizens’ Assembly on the Public Discourse Regarding Abortion, 2016-2019
––Lifeboat Ethics: The Case Against Helping the Poor
For more information and/or to receive a copy of the readings visit http://belmont.bme.umich.edu/bioethics-discussion-group/discussions/060-abdication/.

––
Before you give up, consider the blog: https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Fri, 08 Jan 2021 09:38:57 -0500 2021-04-20T19:00:00-04:00 2021-04-20T20:30:00-04:00 Lurie Biomedical Engineering The Bioethics Discussion Group Lecture / Discussion Abdication
National Prescription Drug Take Back Day (April 24, 2021 10:00am) https://events.umich.edu/event/83798 83798-21532314@events.umich.edu Event Begins: Saturday, April 24, 2021 10:00am
Location: Off Campus Location
Organized By: Michigan Medicine

The United States is currently experiencing an epidemic of prescription drug misuse and abuse. Opioid overdoses in Michigan have surged during the COVID-19 pandemic. To help combat this epidemic, the Michigan Opioid Prescribing Engagement Network (Michigan OPEN) is partnering with hospitals, pharmacies, community organizations and police departments around the state to host medication take back events on Saturday, April 24 from 10 a.m. to 2 p.m.

Research has found that about 70 percent of the opioids prescribed for surgery go unused and those medications are not disposed of. This increases the potential for these medications to be diverted back into the community or contaminate waterways. However, Michigan OPEN’s efforts with take back events have led to more than 13,000 pounds of unused medications and approximately 235,000 opioids being collected and properly disposed of.

Take back events provide a safe process for disposing of unused medications while protecting our communities, children and environment. Remove the risk from your home and bring any unused opioids to a Take Back Event in your community.

Find take back event locations throughout Michigan by visiting http://michigan-open.org/.

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Other Mon, 19 Apr 2021 14:05:02 -0400 2021-04-24T10:00:00-04:00 2021-04-24T14:00:00-04:00 Off Campus Location Michigan Medicine Other Medication take back event
RNA Seminar featuring: Olivia Rissland, University of Colorado School of Medicine (May 3, 2021 4:00pm) https://events.umich.edu/event/81302 81302-20881902@events.umich.edu Event Begins: Monday, May 3, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

Registration Required: https://umich.zoom.us/webinar/register/WN_vA9zYS5nSEenf8Zmt1f-qA


ABSTRACT: The maternal-to-zygotic transition (MZT) is a conserved step in animal development, where control is passed from the maternal to the zygotic genome. Although the MZT is typically considered from its impact on the transcriptome, we previously found that three maternally deposited Drosophila RNA binding proteins (ME31B, Trailer Hitch [TRAL], and Cup) are also cleared during the MZT by unknown mechanisms. Here, we show that these proteins are degraded by the ubiquitin-proteasome system. Marie Kondo, an E2 conjugating enzyme, and the E3 CTLH ligase are required for the destruction of ME31B, TRAL, and Cup. Structure modeling of the Drosophila CTLH complex suggests that substrate recognition is different than orthologous complexes. Despite occurring hours earlier, egg activation mediates clearance of these proteins through the Pan Gu kinase, which stimulates translation of Kondo mRNA. Clearance of the maternal protein dowry thus appears to be a coordinated, but as-yet underappreciated, aspect of the MZT.

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Lecture / Discussion Fri, 02 Apr 2021 16:07:11 -0400 2021-05-03T16:00:00-04:00 2021-05-03T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Olivia Rissland, Ph.D.
RNA Seminar featuring: Thomas Martinez, Salk Institute for Biological Studies (May 17, 2021 4:00pm) https://events.umich.edu/event/81303 81303-20881903@events.umich.edu Event Begins: Monday, May 17, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

Registration Required: https://umich.zoom.us/webinar/register/WN_90RkcQTGQZa7ifQ8kbSdNQ

KEYOWORDS: microprotein, smORF, ribosome profiling

ABSTRACT: Functional protein-coding small open reading frames (smORFs) are emerging as an important class of genes. Several smORF-encoded microproteins have been characterized and implicated in a variety of critical processes, including regulation of mRNA decay, DNA repair, and muscle formation. Thus, rigorous and comprehensive annotation of protein-coding smORFs is critical to our understanding of basic biology and physiology, as well as disease. We recently developed an improved workflow that integrates de novo transcriptome assembly and ribosome profiling to overcome obstacles with previous methods to more confidently annotate thousands of novel smORFs across multiple human cell lines, including hundreds encoded on putative non-coding RNAs. Over 1,500 smORFs are found in two or more cell lines, and ~40% lack a canonical AUG start codon. Evolutionary conservation analyses suggest that hundreds of smORF-encoded microproteins are likely functional. We also find that smORF-derived peptides are detectable on human leukocyte antigen complexes, positioning smORFs as a source of novel antigens. The annotation of protein-coding smORFs radically alters the current view of the human genome’s coding capacity and will provide a rich pool of unexplored, functional human genes.

BIO: Thomas received his B.S. in Biological Engineering from MIT and trained in Prof. JoAnne Stubbe’s laboratory, where he studied the mechanism of ribonucleotide reductase. He then recieved his Ph.D. in Biochemistry & Molecular Biophysics from Caltech as an NIH NRSA predoctoral fellow under the mentorship of Prof. Peter Dervan. His thesis work focused primarily on characterizing the effects of DNA binding pyrrole-imidazole polyamides on DNA replication in prostate cancer cells. Thomas is currently an NIH NRSA postdoctoral fellow in Prof. Alan Saghatelian’s laboratory, where he has developed an integrative platform combining ribosome profiling and de novo transcriptome assembly to discover functional smORF encoded microproteins in the human genome.

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Lecture / Discussion Wed, 14 Apr 2021 12:39:54 -0400 2021-05-17T16:00:00-04:00 2021-05-17T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Thomas Martinez, Salk Institute for Biological Studies
RNA Innovation Seminar featuring Rising Scholars: Khan & McMillan (June 14, 2021 4:00pm) https://events.umich.edu/event/83934 83934-21619166@events.umich.edu Event Begins: Monday, June 14, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

Registration Required: https://umich.zoom.us/webinar/register/WN_uLz-ONHVQPuRINMYUNvBJQ

“CCR5 as a model to examine reporter assays in evaluating translational phenomena”
Yousuf Khan
Knight-Hennessy Scholar
Stanford University

KEYWORDS: dual luciferase, frameshifting, recoding, CCR5
ABSTRACT: During the decoding of a subset of mRNAs, a proportion of ribosomes productively shift to the −1 reading frame at specific slippage-prone sites in a phenomenon known as programmed −1 ribosomal frameshifting (−1 PRF) to generate a frameshifted, C-terminally unique protein. The first experimentally verified occurrence of functionally utilized non-retroelement derived −1 PRF in humans has been reported in the mRNA encoding the immune-functioning C-C chemokine receptor 5 (CCR5). Here, we show that frameshifting does not occur during CCR5 decoding. Apart from its importance in understanding expression of a gene relevant to cancer, an HIV-1 receptor (and the associated claimed rationale for generating the first humans derived from genetically modified embryos), the findings imply that caution is appropriate in assessing results from translational reporter assays.

~and~

“Intersection between RNA methylation and TDP43-mediated toxicity in ALS”
Michael McMillan
Ph.D. candidate
Cellular and Molecular Biology
University of Michigan

KEYWORDS: TDP43, m6A, ALS, RNA stability
ABSTRACT: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease resulting in the death of upper and lower motor neurons. ALS has no known cure and limited therapeutic options, and the underlying pathological mechanisms remain unclear. Despite considerable variability in clinical presentation, over 95% of ALS cases exhibit cytoplasmic inclusions of the RNA binding protein TDP43. Emerging evidence suggests that TDP43 is crucial for RNA stability, and that dysregulation of RNA homeostasis may contribute to ALS pathogenesis.
Methylation of RNA at the 6th position nitrogen (N6-methyladenosine methylation, or m6A) by methyltransferases (writers) or removal of methyl groups by demethylases (erasers) has dramatic effects on RNA stability and translation mediated by a family of RNA biding proteins that recognize methylated RNA (readers). m6A writers and erasers specifically localize to nuclear speckles, membraneless nuclear organelles rich in RNA binding proteins and splicing factors, including TDP43. Together with our data showing that TDP43 regulates RNA stability, these observations suggest that TDP43 may destabilize m6A modified RNA. Here, we show that methylated RNA co-purified with TDP43 from cultured cells via RNA immunoprecipitation, and abrogation of methylation sites disrupted TDP43 binding, suggesting that TDP43 recognizes m6A modified RNA in cellulo. We also noted profound and widespread hypermethylation of coding and non-coding transcripts in ALS spinal cord, many overlapping with confirmed TDP43 target transcripts. Consistent with a central role for m6A modification in TDP43-mediated toxicity, we identified several factors operating within the m6A pathway that enhance or suppress the toxicity of TDP43 in rodent primary cortical neurons via a single-cell CRISPR/Cas9 candidate-based screen. Genetic knockout of the established m6A reader YTHDF2 rescued TDP43 toxicity in primary neurons, and YTHDF2 was also upregulated in ALS postmortem sections. Together, these data imply a fundamental link between m6A RNA modifications and ALS pathogenesis, potentially mediated by TDP43-dependent RNA destabilization.

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Lecture / Discussion Tue, 18 May 2021 14:31:45 -0400 2021-06-14T16:00:00-04:00 2021-06-14T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Yousuf Khan (Stanford) & Mike McMillan (U-M)
Precision Health Graduate Certificate Program - Information Session (June 17, 2021 1:00pm) https://events.umich.edu/event/84199 84199-21620752@events.umich.edu Event Begins: Thursday, June 17, 2021 1:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Plan to attend this information session to learn more about the growing field of precision health which seeks to tailor health care for individuals via a multidisciplinary, data-driven approach.

The new U-M Precision Health Graduate Certificate Program has arrived to educate current and future practitioners and researchers in this emerging field so they can become better equipped to customize patient care.

**Only 12 credits of graduate coursework required
**Great opportunity for graduate students to design their own plan
**Network with other precision health students and faculty at seminars and professional development workshops
**Mentoring with faculty

The certificate is open to all graduate students enrolled at U-M. Application deadline is August 1.

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Other Thu, 03 Jun 2021 10:50:45 -0400 2021-06-17T13:00:00-04:00 2021-06-17T13:30:00-04:00 Off Campus Location Department of Learning Health Sciences Other learners and researchers in lab, classroom and research settings
LHS Collaboratory-Summer Workshop (June 24, 2021 1:00pm) https://events.umich.edu/event/83809 83809-21538171@events.umich.edu Event Begins: Thursday, June 24, 2021 1:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

This virtual workshop will review the basic concepts behind Learning Health Systems including the learning cycle, infrastructure, and learning communities.  Participants will engage in a collaborative activity to design a learning cycle.

Registration for this virtual event is limited-
please register early!

Charles P. Friedman

Department Chair of Learning Health Sciences
Josiah Macy Jr. Professor of Medical Education
Professor of Information
Professor of Public Health
University of Michigan

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Workshop / Seminar Tue, 20 Apr 2021 10:17:48 -0400 2021-06-24T13:00:00-04:00 2021-06-24T16:00:00-04:00 Off Campus Location Department of Learning Health Sciences Workshop / Seminar LHS Collaboratory logo
Precision Health Graduate Certificate Program (July 22, 2021 1:00pm) https://events.umich.edu/event/84318 84318-21623289@events.umich.edu Event Begins: Thursday, July 22, 2021 1:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

The new U-M Precision Health Graduate Certificate Program has arrived to educate current and future practitioners and researchers in this emerging field so they can become better equipped to customize patient care.

**Only 12 credits of graduate coursework required
**Great opportunity for graduate students to design their own plan
**Network with other precision health students and faculty at seminars and professional development workshops

**Mentoring with faculty

The certificate is open to all graduate students enrolled at U-M. Application deadline is August 1.

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Presentation Fri, 18 Jun 2021 14:24:55 -0400 2021-07-22T13:00:00-04:00 2021-07-22T13:30:00-04:00 Off Campus Location Department of Learning Health Sciences Presentation researchers, learners and health professional in lab, classroom and clinic setting
Precision Health Graduate Certificate Program - Information Session (July 22, 2021 1:00pm) https://events.umich.edu/event/84201 84201-21620757@events.umich.edu Event Begins: Thursday, July 22, 2021 1:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Plan to attend this information session to learn more about the growing field of precision health which seeks to tailor health care for individuals via a multidisciplinary, data-driven approach.

The new U-M Precision Health Graduate Certificate Program has arrived to educate current and future practitioners and researchers in this emerging field so they can become better equipped to customize patient care.

**Only 12 credits of graduate coursework required
**Great opportunity for graduate students to design their own plan
**Network with other precision health students and faculty at seminars and professional development workshops
**Mentoring with faculty

The certificate is open to all graduate students enrolled at U-M. Application deadline is August 1.

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Other Thu, 03 Jun 2021 11:00:29 -0400 2021-07-22T13:00:00-04:00 2021-07-22T13:30:00-04:00 Off Campus Location Department of Learning Health Sciences Other learners and researchers in lab, classroom and research settings