Happening @ Michigan https://events.umich.edu/list/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. MCDB Seminar: In Toto Imaging in Zebrafish Shows How Cells 'Build' Patterns (December 6, 2019 12:00pm) https://events.umich.edu/event/67363 67363-16839929@events.umich.edu Event Begins: Friday, December 6, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Cunming Duan

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Workshop / Seminar Tue, 17 Sep 2019 17:08:59 -0400 2019-12-06T12:00:00-05:00 2019-12-06T13:00:00-05:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar digital image fish embryo
Science Forum Demo- Life: How do we find it? (December 7, 2019 3:00pm) https://events.umich.edu/event/69340 69340-17310083@events.umich.edu Event Begins: Saturday, December 7, 2019 3:00pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

Saturdays and Sundays, 3:00 p.m.

Discover how scientists search for life on other planets. Explore the field of astrobiology and re-evaluate your definition of life. Observe a re-creation of an experiment from the Mars Viking Lander expedition, and learn about what kinds of planets might support life.

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Presentation Tue, 12 Nov 2019 12:29:00 -0500 2019-12-07T15:00:00-05:00 2019-12-07T15:20:00-05:00 Biological Sciences Building Museum of Natural History Presentation Biological Sciences Building
Biodiversity Lab Chat (December 7, 2019 3:30pm) https://events.umich.edu/event/69343 69343-17310096@events.umich.edu Event Begins: Saturday, December 7, 2019 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the website or Welcome Desk for times.

Stop by and chat with an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world.

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Other Tue, 12 Nov 2019 12:44:15 -0500 2019-12-07T15:30:00-05:00 2019-12-07T15:45:00-05:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
Science Forum Demo- Life: How do we find it? (December 8, 2019 3:00pm) https://events.umich.edu/event/69340 69340-17310085@events.umich.edu Event Begins: Sunday, December 8, 2019 3:00pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

Saturdays and Sundays, 3:00 p.m.

Discover how scientists search for life on other planets. Explore the field of astrobiology and re-evaluate your definition of life. Observe a re-creation of an experiment from the Mars Viking Lander expedition, and learn about what kinds of planets might support life.

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Presentation Tue, 12 Nov 2019 12:29:00 -0500 2019-12-08T15:00:00-05:00 2019-12-08T15:20:00-05:00 Biological Sciences Building Museum of Natural History Presentation Biological Sciences Building
Medical School Inside Story (December 9, 2019 5:00pm) https://events.umich.edu/event/65982 65982-16678385@events.umich.edu Event Begins: Monday, December 9, 2019 5:00pm
Location: University Hospitals
Organized By: Science Learning Center

Do you have questions about medical school admissions? Get your answers straight from the inside! U-M Medical School Admissions Director Carol Teener will demystify medical school applications, expectations, and reviews in her presentation.

Please submit your questions via the following link: https://forms.gle/49SpHo8WZLLfuUuR8 by Monday, December 2 and Director Teener will answer as many commonly-asked questions as possible in the allotted hour.

This session will take place in the University of Michigan Hospital's Ford Auditorium.
We recommend that you leave yourself extra time to find the auditorium if you have not been there before!

Registration Link: http://ttc.iss.lsa.umich.edu/undergrad/sessions/medical-school-inside-story-2/

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Workshop / Seminar Wed, 04 Sep 2019 15:41:30 -0400 2019-12-09T17:00:00-05:00 2019-12-09T18:00:00-05:00 University Hospitals Science Learning Center Workshop / Seminar
EEB Tuesday Lunch Seminar: Sensory evolution in the transition from land to sea: how do sea snakes sense their underwater world? (December 10, 2019 12:00pm) https://events.umich.edu/event/65011 65011-16501309@events.umich.edu Event Begins: Tuesday, December 10, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Please join us for our weekly brown bag lunch seminar.

Abstract
The senses are our interface with our surrounding world and attuned to specific qualities of prominent signals within the environment. Studying the ways in which senses have changed during evolution can be a marker of how organisms respond to major ecological shifts. Snakes have invaded aquatic habitats multiple times, but, with over 60 fully-aquatic and ecologically diverse species, few groups have been so successful as sea snakes (Elapidae: Hydrophiinae). I will explore the sensory evolution of sea snakes, with emphasis on two senses that are mediated by the skin: mechanoreception (touch) and tail phototaxis (skin photoreception). Tiny mechanoreceptors on the scales of sea snakes have undergone substantial changes during evolution, I will discuss whether these morphological changes are likely to confer a 'hydrodynamic' function (analogous to the lateral line system of fishes) in sea snakes. Light sensitivity of the paddle-tail in sea snakes (tail phototaxis) is a rare trait among vertebrates and convergent with other elongate, aquatic species (hagfish, lamprey, aquatic salamanders). I explore the evolutionary origins, genetic mechanisms and ecological factors underlying this fascinating sense in sea snakes.

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Workshop / Seminar Thu, 05 Dec 2019 10:42:20 -0500 2019-12-10T12:00:00-05:00 2019-12-10T13:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar sea snake swimming underwater
Strategies Transcription Factors Use to Target "Inaccessible" DNA -Department of Biological Chemistry Seminar (December 10, 2019 12:00pm) https://events.umich.edu/event/69812 69812-17431797@events.umich.edu Event Begins: Tuesday, December 10, 2019 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Michael Poirier, Professor of Physics at Ohio State University, will present the Department of Biological Chemistry seminar on Tuesday December 10th at 12pm in North Lecture Hall, MS II.

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Workshop / Seminar Wed, 27 Nov 2019 07:29:14 -0500 2019-12-10T12:00:00-05:00 2019-12-10T13:00:00-05:00 Medical Science Unit II Biological Chemistry Workshop / Seminar Michael Poirier
Complex Systems presents: A Nobel Symposium 2019 (December 10, 2019 1:00pm) https://events.umich.edu/event/69228 69228-17269240@events.umich.edu Event Begins: Tuesday, December 10, 2019 1:00pm
Location: Weiser Hall
Organized By: The Center for the Study of Complex Systems

Eight scholars discuss the work, impact, and personality of the Laureates of this year's SEVEN! Nobel Prizes. (Snacks and coffee will be provided throughout the afternoon)

FREE AND OPEN TO THE PUBLIC – STUDENTS ENCOURAGED TO ATTEND - TALKS ARE GEARED TO A GENERAL AUDIENCE - COME TO ONE, COME TO ALL

SCHEDULE:
1:00-1:05pm INTRODUCTION
1:05-1:40pm CHEMISTRY
1:40-2:15pm PHYSICS
2:15-2:20pm 5 minute snack/coffee break
2:20-2:55pm MEDICINE
2:55-3:35pm ECONOMIC SCIENCES
3:35-4:15pm PEACE PRIZE
4:15-4:20pm 5 minute snack/coffee break
4:20-4:55pm LITERATURE 2018
4:55-5:30pm LITERATURE 2019


1:05 PM CHEMISTRY – Wei Lu, Director, ABCD Battery Research Center and Professor, Mechanical Engineering will discuss the Chemistry prize shared by: John Goodenough (b. Germany, University of Texas (Austin)); M. Stanley Whittingham (b. UK, Binghamton University, State University of New York); and Akira Yoshino (b. Japan, Asahi Kasei Corporation, Tokyo) in recognition of their work "for the development of lithium-ion batteries”

1:40 PM PHYSICS - Fred Adams, Professor of Physics and Astronomy, will discuss the Physics prize shared by James Peebles (b. Canada, Princeton) “for theoretical discoveries in physical cosmology”
and Michel Mayor (b. Switzerland, U. of Geneva), Didier Queloz (b. Switzerland U. of Geneva & Cambridge) for “the discovery of an exoplanet orbiting a solar-type star.”

2:20 PM MEDICINE - Yatrik Shah, Professor, Molecular and Integrative Physiology & Internal Medicine - Gastroenterology will discuss the Medicine prize shared by William G. Kaelin Jr. (b. USA, Harvard Medical School &, Howard Hughes Medical Institute); Sir Peter J. Ratcliffe (b. UK, Oxford; Francis Crick Institute) and Gregg L. Semenza (b. USA, Johns Hopkins University) “for their discoveries of how cells sense and adapt to oxygen availability.”

2:55 PM ECONOMIC SCIENCES - Dean Yang, Professor Economics, Public Policy; Pop. Studies Center, will discuss the Economics prize shared by Abhijit Banerjee (b. Inida, MIT); Esther Duflo (b. FRANCE, MIT); and Michael Kremer (b. USA (NY), Harvard) “for their experimental approach to alleviating global poverty.”

3:35 PM PEACE - Laura Nyantung Beny - Professor of Law, Associate Director of African Studies Center, UM, will discuss the award to Abiy Ahmed Ali (b. Ethiopia, Prime Minister FDRE) who received the prize “for promoting peace and reconciliation”.

4:20 PM LITERATURE 2018 – Benjamin Paloff, Professor of Slavic Languages and Literatures & of Comparative Literature will discuss the award of the delayed 2018 Literature prize - Olga Tokarczuk (b. POLAND, Author) "for a narrative imagination that with encyclopedic passion represents the crossing of boundaries as a form of life."

4:55 PM LITERATURE 2019 - Johannes von Moltke, Professor of Germanic Languages and Literatures & Professor of Film, Television and Media together with Teresa Kovacs, Professor of Germanic Studies, Indiana University will discuss laureate Peter Handke (b. POLAND, Author) who was awarded the prize "for an influential work that with linguistic ingenuity has explored the periphery and the specificity of human experience"

Each presentation will be 30 minutes followed by a Q & A.

Illustrations of Nobel Peace Prize Winners reprinted with permission of the illustration artist Niklas Elmehed. Copyright Nobel Media.

Organizer: Robert Deegan

Questions? Call 734-763-3301 or email cscs@umich.edu

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Conference / Symposium Mon, 25 Nov 2019 16:58:48 -0500 2019-12-10T13:00:00-05:00 2019-12-10T17:30:00-05:00 Weiser Hall The Center for the Study of Complex Systems Conference / Symposium Nobel Symposium 2019
SEAS Seminar: Forecasting Global Change Impacts on Biodiversity (December 10, 2019 2:00pm) https://events.umich.edu/event/69493 69493-17327228@events.umich.edu Event Begins: Tuesday, December 10, 2019 2:00pm
Location: Dana Natural Resources Building
Organized By: Program in the Environment (PitE)

Janet Franklin has been in the Department of Botany, University of California at Riverside since 2017. She was previously a Regent's Professor Schools of Geographical Sciences and Urban Planning at Arizona State University where she was appointed in 2009. From 1988-2009 she was on the faculties of Geography and Biology at San Diego State University. She specializes in Landscape Ecology, Biogeography, and Geographic Information Science. Franklin’s research is focused on in the patterns and dynamics of terrestrial plant communities at the landscape scale. Her work addresses the impacts of human-caused landscape change on the environment. Human land use -- agriculture and urbanization -- and other large-scale human impacts such as climate change, and the introduction of exotic species, often interact with natural disturbance regimes such as fire, flooding and hurricanes, to shape plant community dynamics in forests, shrublands, and other ecosystems.

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Presentation Thu, 14 Nov 2019 15:47:54 -0500 2019-12-10T14:00:00-05:00 2019-12-10T16:00:00-05:00 Dana Natural Resources Building Program in the Environment (PitE) Presentation Dana Natural Resources Building
Bioethics Discussion: Antinatalism (December 10, 2019 7:00pm) https://events.umich.edu/event/52723 52723-12974156@events.umich.edu Event Begins: Tuesday, December 10, 2019 7:00pm
Location: Lurie Biomedical Engineering
Organized By: The Bioethics Discussion Group

A discussion on the end to our means.

Readings to consider:
1. The Last Messiah
2. Why It Is Better Never to Come into Existence
3. Every Conceivable Harm: A Further Defence of Anti-Natalism
4. The Ethics of Procreation and Adoption

For more information and/or to receive a copy of the readings contact Barry Belmont at belmont@umich.edu or visit http://belmont.bme.umich.edu/bioethics-discussion-group/discussions/037-antinatalism/.

Tell your descendants to consider the blog: https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Tue, 13 Aug 2019 10:54:42 -0400 2019-12-10T19:00:00-05:00 2019-12-10T20:30:00-05:00 Lurie Biomedical Engineering The Bioethics Discussion Group Lecture / Discussion Antinatalism
BME Seminar: Alexandra Rutz (December 11, 2019 9:00am) https://events.umich.edu/event/69696 69696-17382664@events.umich.edu Event Begins: Wednesday, December 11, 2019 9:00am
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Remarkable advances in medicine and biology have been made possible with bioelectronics – devices that bridge and connect the worlds of living systems and electronics. Bioelectronics include wearable sensors for health monitoring, in vitro diagnostics, therapeutic implantable devices, and electrical stimulation for tissue engineering and regeneration. Despite their influence, bioelectronic devices are still limited by the fact that they are disparate and distinct from biology. The quality of the device-tissue interface is poor and diminishes with time; this is thought to be due to many factors including significant surgical trauma, an aggressive foreign body response, poor material compatibility with the biological milieu, as well as imprecise and distant connections between electronics and surrounding cells or tissues. Towards addressing these challenges, I will first present the use of slippery surfaces for mitigating the consequences of implanting bioelectronics into delicate tissues. I will demonstrate how liquid-infused elastomers reduce tissue deformation and tearing associated with the insertion of intracortical probes in rats. I will then present how, unlike typical electronic fabrication processes, additive manufacturing is compatible with biomaterials and cells. I will demonstrate that when “inks”, processing methods, and scaffold structure are engineered appropriately, extrusion-based 3D printing affords patterned, viable, and functional cell networks, and I will discuss how this can be exploited in future bioelectronic devices. To conclude, I will briefly present my vision to continue tackling the pressing challenges of biointegration that bioelectronics face in expanding their clinical and scientific impacts. The Rutz Lab will engineer “electronic tissues” that merge electronics and biology using additive manufacturing and biomaterials approaches.

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Lecture / Discussion Thu, 21 Nov 2019 10:42:20 -0500 2019-12-11T09:00:00-05:00 2019-12-11T10:00:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Lecture / Discussion BME Logo
CDB Seminar: Molecularly distinct roles of chromatin regulation in cortical development (December 11, 2019 9:30am) https://events.umich.edu/event/69625 69625-17368342@events.umich.edu Event Begins: Wednesday, December 11, 2019 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

2019 Cell & Developmental Biology Seminar Series

Hosted By: Dawen Cai, PhD

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Lecture / Discussion Tue, 19 Nov 2019 17:35:04 -0500 2019-12-11T09:30:00-05:00 2019-12-11T10:30:00-05:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion CDB Seminar - Kwan
LSI Seminar Series: Jon Clardy, Ph.D., Harvard Medical School (December 12, 2019 12:00pm) https://events.umich.edu/event/69745 69745-17415369@events.umich.edu Event Begins: Thursday, December 12, 2019 12:00pm
Location: Palmer Commons
Organized By: Life Sciences Institute (LSI)

Abstract:
Numerous studies with varying degrees of statistical power have found correlations between the composition of the bacterial population in the human gut microbiome and disease states. But the molecules and mechanism(s) connecting a dysbiotic microbiome to a specific disease are generally unknown. In an attempt to address this gap, we undertook a series of screens to link bacterial metabolites with diseases like type 1 diabetes (T1D) and inflammatory bowel disease (IBD). We focused on primary drivers of inflammation like TNFα (tumor necrosis factor alpha) produced by human dendritic cells. This seminar will describe our screening logic, the selection of candidate bacterial strains, the discovery of the small molecule regulators of cytokine production, their structures and biosynthesis, and inflammatory mechanism.

About the speaker:
Jon Clardy obtained his B.S. degree from Yale University and his Ph.D. from Harvard University, both in chemistry. He has served on the Chemistry Department faculties of Iowa State University and Cornell University, and he is currently the Hsien Wu & Daisy Yen Wu Professor of Biological Chemistry & Molecular Pharmacology at Harvard Medical School. His research has focused on naturally occurring biologically active small molecules, their macromolecular targets, and their roles in biology and medicine. His current interests involve the molecular underpinnings of complex symbiotic systems involving both prokaryotes and eukaryotes, bacterial influences on animal and plant development, bacterial communications, and the influence of the human gut microbiome on human health and disease. He currently lectures in graduate courses and teaches a Freshman Seminar entitled Psychoactive Molecules from Babylon to Breaking Bad to Harvard undergraduates.

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Lecture / Discussion Mon, 25 Nov 2019 08:34:01 -0500 2019-12-12T12:00:00-05:00 2019-12-12T13:00:00-05:00 Palmer Commons Life Sciences Institute (LSI) Lecture / Discussion LSI Seminar Series
EEB dissertation defense: Plant invasions and microbes: the interactive effects of plant-associated microbes on invasiveness of Phragmites australis (December 13, 2019 10:00am) https://events.umich.edu/event/68330 68330-17046009@events.umich.edu Event Begins: Friday, December 13, 2019 10:00am
Location: Rackham Graduate School (Horace H.)
Organized By: Ecology and Evolutionary Biology

Wes Bickford defends his doctoral dissertation.

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Presentation Thu, 12 Dec 2019 11:30:38 -0500 2019-12-13T10:00:00-05:00 2019-12-13T11:00:00-05:00 Rackham Graduate School (Horace H.) Ecology and Evolutionary Biology Presentation scene of phragmites growing on the shore of a lake
RNA Innovation Seminar, Silvie Rouskin, Whitehead/MIT (December 16, 2019 4:00pm) https://events.umich.edu/event/65144 65144-16541444@events.umich.edu Event Begins: Monday, December 16, 2019 4:00pm
Location: Palmer Commons
Organized By: Center for RNA Biomedicine

Silvie Rouskin, Ph.D., Andria and Paul Heafy Whitehead Fellow, Whitehead/MIT

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Lecture / Discussion Wed, 04 Dec 2019 11:08:39 -0500 2019-12-16T16:00:00-05:00 2019-12-16T17:00:00-05:00 Palmer Commons Center for RNA Biomedicine Lecture / Discussion flyer
Biosciences Initiative Second Annual Community Celebration and Symposium with President Schlissel (December 16, 2019 4:30pm) https://events.umich.edu/event/69140 69140-17252904@events.umich.edu Event Begins: Monday, December 16, 2019 4:30pm
Location: Michigan League
Organized By: Biosciences Initiative

Celebrating progress of the second year and introducing our 2019 Scientific Initiatives and Exploratory awardees.

The Biosciences Initiative is hosting its second annual community celebration, recognizing the progress of the second year and introducing its most recently awarded projects and groups.

Don't miss your opportunity to learn about these exciting proposals and connect with President Schlissel and fellow members of the biosciences community.

The Biosciences Initiative focuses on funding cutting-edge interdisciplinary research, expert faculty hires, and postgraduate education across the biological sciences at U-M.

Reception with free food and beverages will follow. RSVP to attend: https://docs.google.com/forms/d/e/1FAIpQLSeVAaOMh-bXpKiIfeMx5PQFEtjADiogJwEHlGkhVcfiiQGZ9w/viewform?usp=sf_link.

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Conference / Symposium Fri, 13 Dec 2019 12:30:00 -0500 2019-12-16T16:30:00-05:00 2019-12-16T18:30:00-05:00 Michigan League Biosciences Initiative Conference / Symposium bacteria and people graphic
CLEM FACULTY CANDIDATE Seminar: The nanoscale shapeshifting of clathrin mediated endocytosis viewed by super-resolution light and electron microscopy (December 17, 2019 9:30am) https://events.umich.edu/event/69626 69626-17368343@events.umich.edu Event Begins: Tuesday, December 17, 2019 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

Hosted By: Correlative Light and Electron Microscopy (CLEM) Search Committee and CDB

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Lecture / Discussion Tue, 19 Nov 2019 17:46:37 -0500 2019-12-17T09:30:00-05:00 2019-12-17T10:30:00-05:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion CLEM FACULTY CANDIDATE Seminar
"What is Sleep? Toward a Cellular and Molecular Comprehension of Sleep Neural Dynamics and Functions" (December 17, 2019 12:00pm) https://events.umich.edu/event/70133 70133-17538849@events.umich.edu Event Begins: Tuesday, December 17, 2019 12:00pm
Location: Palmer Commons
Organized By: Department of Molecular, Cellular, and Developmental Biology

Joint seminar with Life Sciences Institute

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Workshop / Seminar Tue, 10 Dec 2019 10:55:25 -0500 2019-12-17T12:00:00-05:00 2019-12-17T13:00:00-05:00 Palmer Commons Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar cartoon drawing of a sleeping cat
BIONIC Lunch: Death Positivity (December 17, 2019 12:00pm) https://events.umich.edu/event/63779 63779-15873597@events.umich.edu Event Begins: Tuesday, December 17, 2019 12:00pm
Location: North Campus Research Complex Building 10
Organized By: The Bioethics Discussion Group

Join us for a lunchtime discussion in the mere hours we have remaining.

Please RSVP: https://forms.gle/HK2mP7nMLiB6L9w3A

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Lecture / Discussion Mon, 23 Sep 2019 14:01:00 -0400 2019-12-17T12:00:00-05:00 2019-12-17T13:30:00-05:00 North Campus Research Complex Building 10 The Bioethics Discussion Group Lecture / Discussion Death Positivity
NO EEB Tuesday Lunch Seminar today (December 17, 2019 12:00pm) https://events.umich.edu/event/65012 65012-16501311@events.umich.edu Event Begins: Tuesday, December 17, 2019 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Tuesday Lunch Seminars resume in the new year, Tuesday, January 14, 2020.

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Workshop / Seminar Tue, 05 Nov 2019 08:52:13 -0500 2019-12-17T12:00:00-05:00 2019-12-17T13:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Biological Sciences Building background, UM EEB logo and text reading EEB Tuesday Lunch Seminars
CDB Seminar: Normal and Disordered Human Erythropoiesis (December 18, 2019 9:30am) https://events.umich.edu/event/69624 69624-17368341@events.umich.edu Event Begins: Wednesday, December 18, 2019 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

2019 Cell & Developmental Biology Seminar Series

Hosted By: Doug Engel, PhD

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Lecture / Discussion Tue, 19 Nov 2019 17:28:01 -0500 2019-12-18T09:30:00-05:00 2019-12-18T10:30:00-05:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion CDB Seminar - Narla
Linking Transcriptome with Morphology in Single Cells via Dynamic Developmental Recording (January 6, 2020 9:30am) https://events.umich.edu/event/70364 70364-17586192@events.umich.edu Event Begins: Monday, January 6, 2020 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

A joint seminar with the Life Sciences Institute

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Workshop / Seminar Mon, 16 Dec 2019 15:30:55 -0500 2020-01-06T09:30:00-05:00 2020-01-06T10:30:00-05:00 Taubman Biomedical Science Research Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Drosophila brain cell imaging
Science Forum Demo- Life: How do we find it? (January 11, 2020 3:00pm) https://events.umich.edu/event/69900 69900-17482970@events.umich.edu Event Begins: Saturday, January 11, 2020 3:00pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

Discover how scientists search for life on other planets. Explore the field of astrobiology and re-evaluate your definition of life. Observe a re-creation of an experiment from the Mars Viking Lander expedition, and learn about what kinds of planets might support life.

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Lecture / Discussion Tue, 03 Dec 2019 12:49:17 -0500 2020-01-11T15:00:00-05:00 2020-01-11T15:20:00-05:00 Biological Sciences Building Museum of Natural History Lecture / Discussion Biological Sciences Building
Biodiversity Lab Chat (January 11, 2020 3:30pm) https://events.umich.edu/event/69903 69903-17482988@events.umich.edu Event Begins: Saturday, January 11, 2020 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the Welcome Desk for times.

Stop by and chat with an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world.

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Other Mon, 06 Jan 2020 10:31:16 -0500 2020-01-11T15:30:00-05:00 2020-01-11T15:45:00-05:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
Science Forum Demo- Life: How do we find it? (January 12, 2020 3:00pm) https://events.umich.edu/event/69900 69900-17482973@events.umich.edu Event Begins: Sunday, January 12, 2020 3:00pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

Discover how scientists search for life on other planets. Explore the field of astrobiology and re-evaluate your definition of life. Observe a re-creation of an experiment from the Mars Viking Lander expedition, and learn about what kinds of planets might support life.

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Lecture / Discussion Tue, 03 Dec 2019 12:49:17 -0500 2020-01-12T15:00:00-05:00 2020-01-12T15:20:00-05:00 Biological Sciences Building Museum of Natural History Lecture / Discussion Biological Sciences Building
Biodiversity Lab Chat (January 12, 2020 3:30pm) https://events.umich.edu/event/69903 69903-17482991@events.umich.edu Event Begins: Sunday, January 12, 2020 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the Welcome Desk for times.

Stop by and chat with an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world.

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Other Mon, 06 Jan 2020 10:31:16 -0500 2020-01-12T15:30:00-05:00 2020-01-12T15:45:00-05:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
LSA Bonderman Fellowship Info Session (January 13, 2020 12:00pm) https://events.umich.edu/event/68404 68404-17077946@events.umich.edu Event Begins: Monday, January 13, 2020 12:00pm
Location: Palmer Commons
Organized By: Center for Global and Intercultural Study

The Bonderman Fellowship offers 4 graduating University of Michigan LSA (Literature, Science and the Arts) seniors $20,000 to travel the world. They must travel to at least 6 countries in 2 regions over the course of 8 months and are expected to immerse themselves in independent and enriching explorations.

Come to a Bonderman information session to learn more about the fellowship and how to apply! Pizza will be provided!

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Presentation Fri, 18 Oct 2019 10:30:00 -0400 2020-01-13T12:00:00-05:00 2020-01-13T13:00:00-05:00 Palmer Commons Center for Global and Intercultural Study Presentation Fellow pictured abroad
RNA Innovation Seminar, David Mathews, University of Rochester (January 13, 2020 4:00pm) https://events.umich.edu/event/65145 65145-16541445@events.umich.edu Event Begins: Monday, January 13, 2020 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

David Mathews , MD, PhD, Professor, Department of Biochemistry & Biophysics, University of Rochester

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Lecture / Discussion Tue, 17 Dec 2019 16:03:20 -0500 2020-01-13T16:00:00-05:00 2020-01-13T17:00:00-05:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion flyer
Heterochromatin Organization and Dynamics- Department of Biological Chemistry Seminar (January 14, 2020 12:00pm) https://events.umich.edu/event/70990 70990-17766487@events.umich.edu Event Begins: Tuesday, January 14, 2020 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Serena Sanulli, Postdoctoral Fellow in the Department of Pharmaceutical Chemistry at UCSF, will give a seminar in the Department of Biological Chemistry on Tuesday 1/14/20 at 12:00pm in North Lecture Hall, MS II.

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Workshop / Seminar Tue, 07 Jan 2020 06:42:55 -0500 2020-01-14T12:00:00-05:00 2020-01-14T13:00:00-05:00 Medical Science Unit II Biological Chemistry Workshop / Seminar Sanulli
“Evolution of vertebrate gill covers through shifts in an ancient gnathostome Pou3f3 enhancer" (January 14, 2020 4:00pm) https://events.umich.edu/event/71205 71205-17785645@events.umich.edu Event Begins: Tuesday, January 14, 2020 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for Cell Plasticity and Organ Design

The NIH T32 Training Program in Organogenesis is pleased to present a Special Series: "Emerging Topics in Tissue Regeneration and Engineering" featuring seminar guest Lindsey Barske, Ph.D.

Dr. Barske is an Assistant Professor, Divisions of Human Genetics & Developmental Biology, Cincinnati Children’s Hospital

The talk is entitled, “Evolution of vertebrate gill covers through shifts in an ancient gnathostome Pou3f3 enhancer”.

Trainee Host: Martha Echevarria-Andino, Ph.D. Candidate-Allen Lab

For additional info: 936-2499 / organogenesis@umich.edu

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Lecture / Discussion Thu, 09 Jan 2020 16:24:44 -0500 2020-01-14T16:00:00-05:00 2020-01-14T17:00:00-05:00 Taubman Biomedical Science Research Building Center for Cell Plasticity and Organ Design Lecture / Discussion Dr. Barske Seminar Flyer
CDB Seminar: Developmental vs Neoplastic Invasion Programs In Vivo: Insights from Branching Morphogenesis and Metastasis (January 15, 2020 9:30am) https://events.umich.edu/event/70640 70640-17611225@events.umich.edu Event Begins: Wednesday, January 15, 2020 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

2020 Cell & Developmental Biology Seminar Series

Hosted By: Doug Engel, PhD

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Lecture / Discussion Thu, 19 Dec 2019 15:27:34 -0500 2020-01-15T09:30:00-05:00 2020-01-15T10:30:00-05:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion CDB Seminar - Weiss
DCMB Weekly Seminar (January 15, 2020 4:00pm) https://events.umich.edu/event/70964 70964-17760238@events.umich.edu Event Begins: Wednesday, January 15, 2020 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract: Synchronization occurs all around us. It underlies how fireflies flash as one, how human heart cells beat in unison, and how superconductors conduct electricity with no resistance. Synchronization is present in the precision of the cell cycle, and we can explore how breakdown of precision leads to disease. The many unique and fundamental functions of different cell types are achieved over and over independently, through a form of synchronization involving choreography of many proteins and genes. I will share a general historic and descriptive introduction to synchrony, including the classic work of Alan Turing. I will present some new work done jointly with Cleve Moler (MathWorks) and Steve Smale (UC Berkeley), where biology has inspired us to build new mathematical techniques to explore synchrony and its breakdown.

BlueJeans Livestream: https://primetime.bluejeans.com/a2m/live-event/rbuvycdc

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Lecture / Discussion Mon, 06 Jan 2020 15:39:08 -0500 2020-01-15T16:00:00-05:00 2020-01-15T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
Being Human in STEM: An Experiment in Partnering with Students to Address Issues of Equity in STEM (January 16, 2020 12:00pm) https://events.umich.edu/event/69259 69259-17275351@events.umich.edu Event Begins: Thursday, January 16, 2020 12:00pm
Location: Rackham Graduate School (Horace H.)
Organized By: LSA Biophysics

When student protesters occupied the Amherst College library for four days in November of 2015, the campus community was transfixed by the painful testimonials shared by marginalized students about their experiences at Amherst as individuals identifying as Black, brown, female, queer, trans, disabled, international, among others. In response to letters from a Black neuroscience major and a non-binary biochemistry and biophysics major, every STEM department wrote a letter of support, pledging to work with students to address their concerns. The following semester, Chemistry professor Sheila Jaswal collaborated with students to develop a project-based course, titled “Being Human in STEM” (HSTEM), to actively engage STEM students and departments in learning about and enhancing inclusion in STEM settings. Now in its sixth iteration, students drive the academic inquiry, investigating both the local experience and the literature on diversity in STEM. They then use that research to design tools and interventions to share with and enhance their own STEM community.  In this seminar, Professor Jaswal will describe how HSTEM course projects and activities have continued the conversation started by students during the Uprising, connected STEM inclusion efforts across the Amherst campus, and produced resources such as the “Inclusive Curricular Practices” handbook, that have been used by STEM educators from high schools, colleges, universities, and the Howard Hughes Medical Institute Inclusive Excellence institutions. She will present evidence on the impact of the HSTEM course and practices on students, faculty and staff at Amherst, and provide examples of how a growing network of institutions, including Yale, Brown, Williams, and the University of Utah, are adapting the HSTEM model to their own STEM community needs. 

Please visit website for more information on speaker: http://www.beinghumaninstem.com/sheila-jaswal.html

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Workshop / Seminar Wed, 08 Jan 2020 12:58:03 -0500 2020-01-16T12:00:00-05:00 2020-01-16T14:00:00-05:00 Rackham Graduate School (Horace H.) LSA Biophysics Workshop / Seminar Rackham Graduate School (Horace H.)
No EEB Thursday Seminar (January 16, 2020 4:00pm) https://events.umich.edu/event/71085 71085-17774972@events.umich.edu Event Begins: Thursday, January 16, 2020 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Please return on January 23, 2020, for our next seminar!

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Conference / Symposium Wed, 08 Jan 2020 12:03:07 -0500 2020-01-16T16:00:00-05:00 2020-01-16T17:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Conference / Symposium Biological Sciences Building
Science Forum Demo- Life: How do we find it? (January 18, 2020 3:00pm) https://events.umich.edu/event/69900 69900-17482971@events.umich.edu Event Begins: Saturday, January 18, 2020 3:00pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

Discover how scientists search for life on other planets. Explore the field of astrobiology and re-evaluate your definition of life. Observe a re-creation of an experiment from the Mars Viking Lander expedition, and learn about what kinds of planets might support life.

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Lecture / Discussion Tue, 03 Dec 2019 12:49:17 -0500 2020-01-18T15:00:00-05:00 2020-01-18T15:20:00-05:00 Biological Sciences Building Museum of Natural History Lecture / Discussion Biological Sciences Building
Biodiversity Lab Chat (January 18, 2020 3:30pm) https://events.umich.edu/event/69903 69903-17482989@events.umich.edu Event Begins: Saturday, January 18, 2020 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the Welcome Desk for times.

Stop by and chat with an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world.

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Other Mon, 06 Jan 2020 10:31:16 -0500 2020-01-18T15:30:00-05:00 2020-01-18T15:45:00-05:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
Science Forum Demo- Life: How do we find it? (January 19, 2020 3:00pm) https://events.umich.edu/event/69900 69900-17482974@events.umich.edu Event Begins: Sunday, January 19, 2020 3:00pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us in the Science Forum for 15-20 minute engaging science demonstrations that will help you see the world in a whole new way. Demonstrations are appropriate for visitors ages 5 and above.

Discover how scientists search for life on other planets. Explore the field of astrobiology and re-evaluate your definition of life. Observe a re-creation of an experiment from the Mars Viking Lander expedition, and learn about what kinds of planets might support life.

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Lecture / Discussion Tue, 03 Dec 2019 12:49:17 -0500 2020-01-19T15:00:00-05:00 2020-01-19T15:20:00-05:00 Biological Sciences Building Museum of Natural History Lecture / Discussion Biological Sciences Building
Biodiversity Lab Chat (January 19, 2020 3:30pm) https://events.umich.edu/event/69903 69903-17482992@events.umich.edu Event Begins: Sunday, January 19, 2020 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the Welcome Desk for times.

Stop by and chat with an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world.

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Other Mon, 06 Jan 2020 10:31:16 -0500 2020-01-19T15:30:00-05:00 2020-01-19T15:45:00-05:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
CDB Seminar: Fat tissue development, renewal and remodeling (January 21, 2020 9:30am) https://events.umich.edu/event/70942 70942-17758099@events.umich.edu Event Begins: Tuesday, January 21, 2020 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

2020 Cell & Developmental Biology Seminar Series

Hosted By: Pierre Coulombe, Ph.D. and Ben Allen, Ph.D.

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Lecture / Discussion Mon, 06 Jan 2020 11:13:23 -0500 2020-01-21T09:30:00-05:00 2020-01-21T10:30:00-05:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion CDB Seminar - Seale
Fluorescence Microscopy Tools to Illuminate RNA and Protein Dynamics in Live Cells (Department of Biological Chemistry Seminar) (January 21, 2020 12:00pm) https://events.umich.edu/event/71069 71069-17774925@events.umich.edu Event Begins: Tuesday, January 21, 2020 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Esther Braselmann, Postdoctoral Fellow at the University of Colorado Boulder, will be presenting the Department of Biological Chemistry Seminar on Tuesday 1/21/2020 at 12 noon in North Lecture Hall, MS II

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Workshop / Seminar Wed, 08 Jan 2020 07:18:32 -0500 2020-01-21T12:00:00-05:00 2020-01-21T13:00:00-05:00 Medical Science Unit II Biological Chemistry Workshop / Seminar
Growth and Grit - Developing a Mindset For Success (January 22, 2020 5:30pm) https://events.umich.edu/event/70897 70897-17735191@events.umich.edu Event Begins: Wednesday, January 22, 2020 5:30pm
Location: Undergraduate Science Building
Organized By: Science Learning Center

What if your ability to succeed in your classes was determined in part before you even stepped into the classroom? What is the one quality you need to overcome adversity academically and in life? This workshop will detail the research of Dr. Carol Dweck and her groundbreaking work on the concept of mindset. Students will learn how to abandon a debilitating fixed mindset in favor of a growth mindset, leading to success in areas they once considered too difficult. The workshop will also introduce students to the research of Dr. Angela Duckworth, and how a growth mindset can lead to the development of grit, an essential characteristic to overcoming our fear of failure.

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Workshop / Seminar Wed, 15 Jan 2020 10:16:28 -0500 2020-01-22T17:30:00-05:00 2020-01-22T19:00:00-05:00 Undergraduate Science Building Science Learning Center Workshop / Seminar
Complex Systems/ICAM Symposium | "Emergence in Communication & Learning" (January 23, 2020 8:30am) https://events.umich.edu/event/70805 70805-17644330@events.umich.edu Event Begins: Thursday, January 23, 2020 8:30am
Location: Rackham Graduate School (Horace H.)
Organized By: The Center for the Study of Complex Systems

The Annual CSCS/ICAM Symposium 2020

Microbes, mice, and mockingbirds, economic markets and electronic machines all communicate but each does so in very different ways. This one-day symposium, sponsored by the University of Michigan's Center for the Study of Complex Systems in collaboration with the Institute for Complex Adaptive Matter, will bring together six leading researchers working across these diverse systems to investigate the emergence of communication and how it facilitates learning and language. The aim is to explore what makes these systems different and, importantly, what they have in common.

This symposium is free and open to the public. REGISTRATION is required for lunch.

Please Register at the link below. REGISTRATION CLOSES JAN. 20

SPEAKERS:

Josh Bongard, The University of Vermont, Computer Science
Jonathan Brennan, University of Michigan, Linguistics & Psychology
Erica Cartmill, UCLA, Anthropology
Stephen Diggle, Georgia Institute of Technology, Biological Sciences
Jacob Foster, UCLA, Sociology
Savithry Namboodiripad, University of Michigan, Linguistics

SCHEDULE

8:30 am Coffee & Light Breakfast

9:00 am Josh Bongard, The University of Vermont, Computer Science “word2vec2bot: Seeking body plans that facilitate language grounding in machines”

10:00 am Coffee Break

10:30 am Stephen Diggle, Georgia Institute of Technology, Biological Sciences “Cell-to-cell communication in bacteria”

11:30 am Erica Cartmill, UCLA, Anthropology "The Emergence of Form and Reference in Development and Evolution"

12:30 pm LUNCH (Registration Required)

1:30 pm Jonathan Brennan, University of Michigan, Linguistics & Psychology "Grammar in the brain"

2:30 pm Savithry Namboodiripad, University of Michigan, Linguistics “Language (contact) is whatever we want it to be: The role of top-down categorization in shaping emergent phenomena”

3:30 pm Coffee Break

4:00 pm Jacob Foster, UCLA, Sociology "Beyond Babel? Context, Convergence, and the Prospects for Universal Communication"

This symposium is free and open to the public. REGISTRATION is required for lunch.

Please Register at the link below. REGISTRATION WILL CLOSE JAN. 20

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Conference / Symposium Tue, 21 Jan 2020 12:34:55 -0500 2020-01-23T08:30:00-05:00 2020-01-23T17:00:00-05:00 Rackham Graduate School (Horace H.) The Center for the Study of Complex Systems Conference / Symposium CSCS/ICAM PRESENT
LSI Seminar Series: Wen-Xing Ding, Ph.D., University of Kansas Medical Center (January 23, 2020 12:00pm) https://events.umich.edu/event/70179 70179-17540934@events.umich.edu Event Begins: Thursday, January 23, 2020 12:00pm
Location: Palmer Commons
Organized By: Life Sciences Institute (LSI)

Abstract:
Liver cells can adapt and protect themselves in response to stress by activating cellular protective mechanisms such as autophagy, which is a lysosomal degradation pathway that degrades cellular organelles and/or proteins as well as lipids inside the autolysosomes. To meet the needs of autophagic degradation, it is critical to maintain sufficient numbers of lysosomes to fuse with autophagosomes that form autolysosomes. Lysosomal biogenesis is regulated by the transcription factor EB (TFEB), which is a master transcription regulator of lysosomal biogenesis and autophagy.

Studies from our lab revealed that TFEB is impaired in alcoholic hepatitis and pancreatitis as well as in acetaminophen-induced liver injury. Overexpression of TFEB protects against alcohol and drug-induced tissue damage whereas deletion of TFEB exacerbates tissue damage. Studies from our lab also demonstrated that Nrf2, a transcription factor regulating antioxidant response, promotes liver injury and liver tumorigenesis in autophagy defective livers. More recently, our work suggests that both hyper- and hypo-activation of MTOR are detrimental to the liver resulting in the development of liver tumors. Together, our studies indicate that autophagy and lysosome play critical roles in maintaining liver homeostasis. Approaches to boost autophagy and TFEB pathways, which are often impaired in chronic liver diseases, may be promising for treating and preventing liver disease including alcoholic and non-alcoholic fatty liver diseases, drug-induced liver injury and liver tumorigenesis.

About the Speaker:
Wen-Xing Ding is a professor in the Department of Pharmacology, Toxicology and Therapeutics at The University of Kansas Medical Center. He received his Ph.D. from the National University of Singapore in 2002 and completed his postdoctoral training at the University of Pittsburgh. Ding has devoted his research career to elucidating mechanisms for regulation of cell death and the adaptive response to cellular injury in the liver. Since 2009, his laboratory has been working on the role of autophagy in alcohol- and drug-induced liver injury. They are particularly interested in how autophagy selectively removes cellular damaged/excess organelles, such as mitochondria and lipid droplets in hepatocytes. Ding has published more than 120 papers in peer-reviewed journals, and his work is currently supported by NIAAA and NIDDK.

In addition to research, Ding has demonstrated outstanding leadership for service. He has been a program committee member of ASIP (American Society of Investigative Pathology) and the AASLD (American Association for the Studies of Liver Disease) 2015 annual meeting. He organized several meetings and symposia for EB meeting, AASLD and GRC. He serves as an associate editor for the journal Autophagy and an editorial board member for several journals, including Hepatology, Cell and the American Journal of Pathology. He also serves as an ad hoc reviewer for NIH grants and a standing member of XNDA.

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Lecture / Discussion Wed, 11 Dec 2019 08:27:09 -0500 2020-01-23T12:00:00-05:00 2020-01-23T13:00:00-05:00 Palmer Commons Life Sciences Institute (LSI) Lecture / Discussion LSI Seminar Series
EEB Thursday Seminar: Explaining drivers of forest dynamics using trait-based approaches (January 23, 2020 4:00pm) https://events.umich.edu/event/69039 69039-17220020@events.umich.edu Event Begins: Thursday, January 23, 2020 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Identifying the mechanisms that drive the structure and dynamics of communities is a major challenge in ecology. Plant traits are being increasingly used to address this challenge as they provide insights into the critical phenotype-environment link. Such information is necessary to apply to questions regarding how forests are responding to changing environments and the implications of those changes for the long-term persistence of forests. In this talk, I will discuss how the use of trait-based approaches and different modeling tools has allowed me to address questions regarding the drivers that shape forests, and species responses to habitat loss and fragmentation.

View YouTube video of seminar: https://youtu.be/bpnFzlHvSpU

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Workshop / Seminar Thu, 02 Apr 2020 13:01:16 -0400 2020-01-23T16:00:00-05:00 2020-01-23T17:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar work in forest fragmentation
Global, Organism-Scale Views of Cell State Heterogeneity & Dynamics Via Novel Single Cell Profiling Techniques (January 27, 2020 11:00am) https://events.umich.edu/event/71734 71734-17877249@events.umich.edu Event Begins: Monday, January 27, 2020 11:00am
Location: Palmer Commons
Organized By: Cell & Developmental Biology

CDB Faculty Candidate Seminar: Global, Organism-Scale Views of Cell State Heterogeneity & Dynamics Via Novel Single Cell Profiling Techniques

Hosted by: CDB Recruitment Committee & the Department of Human Genetics

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Lecture / Discussion Mon, 20 Jan 2020 09:27:44 -0500 2020-01-27T11:00:00-05:00 2020-01-27T12:00:00-05:00 Palmer Commons Cell & Developmental Biology Lecture / Discussion Global, Organism-Scale Views of Cell State Heterogeneity & Dynamics Via Novel Single Cell Profiling Techniques - Junyue Cao, Ph.D
LSA Bonderman Fellowship Info Session (January 27, 2020 5:00pm) https://events.umich.edu/event/68404 68404-17077948@events.umich.edu Event Begins: Monday, January 27, 2020 5:00pm
Location: Michigan League
Organized By: Center for Global and Intercultural Study

The Bonderman Fellowship offers 4 graduating University of Michigan LSA (Literature, Science and the Arts) seniors $20,000 to travel the world. They must travel to at least 6 countries in 2 regions over the course of 8 months and are expected to immerse themselves in independent and enriching explorations.

Come to a Bonderman information session to learn more about the fellowship and how to apply! Pizza will be provided!

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Presentation Fri, 18 Oct 2019 10:30:00 -0400 2020-01-27T17:00:00-05:00 2020-01-27T18:00:00-05:00 Michigan League Center for Global and Intercultural Study Presentation Fellow pictured abroad
“Overcoming biological barriers to nucleic acid delivery” (January 28, 2020 4:00am) https://events.umich.edu/event/71237 71237-17794025@events.umich.edu Event Begins: Tuesday, January 28, 2020 4:00am
Location: Taubman Biomedical Science Research Building
Organized By: Center for Cell Plasticity and Organ Design

The NIH T32 Training Program in Organogenesis is pleased to present a Special Series: "Emerging Topics in Tissue Regeneration and Engineering" featuring seminar guest Micheal J. Mitchell, Ph.D.

Dr. Mitchell is a Skirkanich Assistant Professor of Innovation, Department of Bioengineering from the University of Pennsylvania.

The talk is entitled, “Overcoming biological barriers to nucleic acid delivery”.

Trainee Host: Sajedeh Nasr Esfahani, Ph.D. Candidate-Jianping Fu Lab

For additional info: 936-2499 / organogenesis@umich.edu

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Lecture / Discussion Fri, 10 Jan 2020 12:00:47 -0500 2020-01-28T04:00:00-05:00 2020-01-28T05:00:00-05:00 Taubman Biomedical Science Research Building Center for Cell Plasticity and Organ Design Lecture / Discussion Mitchell Seminar Flyer
Investigating Protein Degradation at the Interface of Chemistry and Biology (January 28, 2020 11:45am) https://events.umich.edu/event/70908 70908-17735213@events.umich.edu Event Begins: Tuesday, January 28, 2020 11:45am
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Faculty Candidate
Host: U. Jakob

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Workshop / Seminar Fri, 24 Jan 2020 13:28:03 -0500 2020-01-28T11:45:00-05:00 2020-01-28T12:45:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials on blue background
EEB Tuesday Lunch Seminar: The complete tree species of Panama (January 28, 2020 12:00pm) https://events.umich.edu/event/69211 69211-17269216@events.umich.edu Event Begins: Tuesday, January 28, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Please join us for our weekly brown bag lunch seminar.

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Workshop / Seminar Thu, 23 Jan 2020 16:07:42 -0500 2020-01-28T12:00:00-05:00 2020-01-28T13:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar View of trees and water in Panama
DCMB Seminar Series (January 29, 2020 4:00pm) https://events.umich.edu/event/71998 71998-17911963@events.umich.edu Event Begins: Wednesday, January 29, 2020 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Talk Title: Experimental and computational strategies to aid compound identification and quantitation in metabolomics

Abstract: Over the past two decades, metabolomics as a technique has moved from the primary domain of analytical chemists to more widespread acceptance by biologists, clinicians and bioinformaticians alike. Metabolomics offers systems-level insights into the critical roles small molecules play in routine cellular processes and myriad disease states. However, certain unique analytical challenges remain prominent in metabolomics as compared to the other ‘omics sciences. These include the difficulty of identifying unknown features in untargeted metabolomics data, and challenges maintaining reliable quantitation within lengthy studies that may span multiple laboratories. Unlike genomics and transcriptomics data in which nearly every quantifiable feature is confidently identified as a matter of course, in typical untargeted metabolomics studies over 80% of features are frequently not mapped to a specific chemical compound. Further, although many metabolomics studies have begun to stretch over a timeframe of years, data quantitation and normalization strategies have not always kept up with the requirements for such large studies. Fortunately, both experimental and computational strategies are emerging to tackle these long-standing challenges. We will report on several techniques in development in our laboratory, ranging from chromatographic fractionation and high-sensitivity data acquisition, to computational strategies to aid in tandem mass spectrometric spectral interpretation. These developments serve to facilitate analysis for both experts and novice users, which should ultimately help improve the biological insight and impact gained from metabolomics data.

BlueJeans livestreaming link: https://primetime.bluejeans.com/a2m/live-event/rbuvycdc

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Lecture / Discussion Fri, 24 Jan 2020 11:07:13 -0500 2020-01-29T16:00:00-05:00 2020-01-29T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
Make It Stick - Research-Based Learning Strategies You Need to Know (January 29, 2020 5:30pm) https://events.umich.edu/event/70899 70899-17735192@events.umich.edu Event Begins: Wednesday, January 29, 2020 5:30pm
Location: Undergraduate Science Building
Organized By: Science Learning Center

The study and learning strategies students often bring to college are often insufficient to help them succeed at the university level. Particularly in challenging STEM courses, students can't simply memorize or cram their way to a good grade. This workshop will focus on the popular learning strategies to avoid, as well as the top three strategies you don't know but are shown by research to be the most effective for long-term learning.

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Workshop / Seminar Wed, 15 Jan 2020 10:18:11 -0500 2020-01-29T17:30:00-05:00 2020-01-29T19:00:00-05:00 Undergraduate Science Building Science Learning Center Workshop / Seminar make it stick by Brown, Roediger III, and McDaniel
LHS Collaboratory: Applications of AI/Machine Learning in Gastroenterology (January 29, 2020 7:00pm) https://events.umich.edu/event/71218 71218-17959605@events.umich.edu Event Begins: Wednesday, January 29, 2020 7:00pm
Location:
Organized By: Department of Learning Health Sciences

Dr. Waljee’s research focuses on tailoring treatment to the specifics of the individual (precision care) with gastrointestinal and liver diseases. He uses artificial intelligence methods such as machine learning and deep learning to improve decision-making for tailored and individualized care to facilitate the delivery of efficient, effective and equitable care, especially in costly diseases and in limited resource settings.
Discussant 1: Karandeep Singh, MD, MMSc, Assistant Professor, University of Michigan Department of Learning Health Sciences and Department of Internal Medicine

Discussant 2: Kayte Spector-Bagdady, JD, MBioethics, Assistant Professor, University of Michigan Department of Obstetrics and Gynecology and Chief of the Research Ethics Service in the Center for Bioethics and Social Sciences in Medicine.

Please register in advance, *dlhs-umi.ch/lhs-collaboratory.*

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Lecture / Discussion Wed, 29 Jan 2020 19:36:03 -0500 2020-01-29T19:00:00-05:00 2020-01-29T20:00:00-05:00 Department of Learning Health Sciences Lecture / Discussion LHS Collaboratory
Global Insights into Brain Diversity, Development, and Lineage at Single-Cell Resolution (January 30, 2020 11:45am) https://events.umich.edu/event/70909 70909-17735214@events.umich.edu Event Begins: Thursday, January 30, 2020 11:45am
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Faculty Candidate
Host: C. Duan

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Workshop / Seminar Fri, 24 Jan 2020 13:26:23 -0500 2020-01-30T11:45:00-05:00 2020-01-30T12:45:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials and yellow microscope on blue background
A Meditation on Juliana v. United States (January 30, 2020 12:00pm) https://events.umich.edu/event/70163 70163-17540919@events.umich.edu Event Begins: Thursday, January 30, 2020 12:00pm
Location: Jeffries Hall
Organized By: Michigan Law Environmental and Energy Law Program

Please join us for the latest installment of the Environmental Law & Policy Program Lecture Series. Professor Lisa Heinzerling from Georgetown Law will deliver a lecture entitled, "A Meditation on Juliana v. United States."

This event is free and open to the public.

Lisa Heinzerling is the Justice William J. Brennan, Jr., Professor of Law at the Georgetown University Law Center. Her specialties include administrative law, environmental law, food law, and torts. She has published several books, including a leading casebook on environmental law and a widely cited critique of the use of cost-benefit analysis in environmental policy (Priceless: On Knowing the Price of Everything and the Value of Nothing).

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Lecture / Discussion Tue, 10 Dec 2019 13:30:24 -0500 2020-01-30T12:00:00-05:00 2020-01-30T13:00:00-05:00 Jeffries Hall Michigan Law Environmental and Energy Law Program Lecture / Discussion
LHS Collaboratory: Applications of AI/Machine Learning in Gastroenterology (January 30, 2020 12:00pm) https://events.umich.edu/event/71218 71218-17787742@events.umich.edu Event Begins: Thursday, January 30, 2020 12:00pm
Location: Michigan Union
Organized By: Department of Learning Health Sciences

Dr. Waljee’s research focuses on tailoring treatment to the specifics of the individual (precision care) with gastrointestinal and liver diseases. He uses artificial intelligence methods such as machine learning and deep learning to improve decision-making for tailored and individualized care to facilitate the delivery of efficient, effective and equitable care, especially in costly diseases and in limited resource settings.
Discussant 1: Karandeep Singh, MD, MMSc, Assistant Professor, University of Michigan Department of Learning Health Sciences and Department of Internal Medicine

Discussant 2: Kayte Spector-Bagdady, JD, MBioethics, Assistant Professor, University of Michigan Department of Obstetrics and Gynecology and Chief of the Research Ethics Service in the Center for Bioethics and Social Sciences in Medicine.

Please register in advance, *dlhs-umi.ch/lhs-collaboratory.*

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Lecture / Discussion Wed, 29 Jan 2020 19:36:03 -0500 2020-01-30T12:00:00-05:00 2020-01-30T13:30:00-05:00 Michigan Union Department of Learning Health Sciences Lecture / Discussion LHS Collaboratory
BME 500: Meghan Driscoll, Ph.D. (January 30, 2020 4:00pm) https://events.umich.edu/event/70418 70418-17594468@events.umich.edu Event Begins: Thursday, January 30, 2020 4:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Signaling is governed not only by the expression levels of molecules, but by their localization via mechanisms as diverse as compartmentalization in organelles, phase separation, and directed transport by motor proteins. Cell morphology likely also modulates the localization of signaling molecules, and recent advances in high-resolution light-sheet microscopy, such as lattice light-sheet microscopy, now allow imaging at the spatiotemporal resolution needed to capture the many undulations and quick dynamics of the 3D cell surface. However, these microscopes generate large datasets with detailed 3D movies that are impossible to interpret without a dedicated computational pipeline. In this seminar, I will introduce u-shape3D, a computer graphics and machine-learning pipeline to probe molecular mechanisms underlying 3D cell morphogenesis. U-shape3D includes a generic morphological motif detector that automatically finds lamellipodia, filopodia, blebs and other motifs in order to test the intriguing possibility that morphogenesis itself affects intracellular signaling.

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Lecture / Discussion Thu, 23 Jan 2020 11:24:58 -0500 2020-01-30T16:00:00-05:00 2020-01-30T17:00:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Lecture / Discussion BME Logo
EEB Thursday Seminar: River capture promotes evolutionary diversification in continental freshwaters (January 30, 2020 4:00pm) https://events.umich.edu/event/69040 69040-17220021@events.umich.edu Event Begins: Thursday, January 30, 2020 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Neotropical freshwaters house one of the greatest concentration of species and phenotypes on Earth, with more than 8,000 fish species representing approximately 10% of all living vertebrates combined, compressed into a tiny volume of aquatic habitat. The diversity of Neotropical freshwater fishes long predates the geological formation of the modern Amazon and Orinoco river basins, and the unparalleled diversity we observe today arose from an excess of speciation over extinction rates operating over a lengthy time period of tens of millions of years. In this paper we summarize the major phylogenetic and biogeographic dimensions of the Neotropical ichthyofauna, and review recent advances in understanding the roles of paleogeography, river capture, and other landscape evolution processes contributing to the formation of this singular fauna.

View YouTube video of seminar: https://youtu.be/1Qsk76-KDDk

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Workshop / Seminar Thu, 02 Apr 2020 13:02:04 -0400 2020-01-30T16:00:00-05:00 2020-01-30T17:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Dr. James Albert map of distribution
U-M Biological Station Information Session (January 30, 2020 5:00pm) https://events.umich.edu/event/70162 70162-17540904@events.umich.edu Event Begins: Thursday, January 30, 2020 5:00pm
Location: Dana Natural Resources Building
Organized By: University of Michigan Biological Station

Prospective students: Come learn about how to earn credits, gain research experience, and have the spring/summer of your life at UMBS. Featuring a student panel, dates & deadlines, and financial aid information.

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Rally / Mass Meeting Mon, 06 Jan 2020 11:38:37 -0500 2020-01-30T17:00:00-05:00 2020-01-30T18:00:00-05:00 Dana Natural Resources Building University of Michigan Biological Station Rally / Mass Meeting Students on a "plant walk" learn tree species around UMBS.
EEB Museums Friday Seminar: Historical ecology of Neotropical freshwater fishes (January 31, 2020 2:00pm) https://events.umich.edu/event/71087 71087-17774974@events.umich.edu Event Begins: Friday, January 31, 2020 2:00pm
Location: Research Museums Center
Organized By: Ecology and Evolutionary Biology

This talk will provide a synoptic overview of a new book project now being prepared by the community of Neotropical ichthyologists entitled Historical Ecology of Neotropical Freshwater Fishes. The humid Neotropics is home to the greatest concentration of biodiversity on Earth for many groups of organisms, including continental (or freshwater) fishes. The full dimensions of Neotropical freshwater fish (NFF) diversity have only come to be appreciated in recent years. As of this writing we have described about 6,088 NFF species, in 854 genera, 95 families and 39 orders. From torrential headwaters cascading off the Andean cordilleras and upland cratonic shields, to the murky waters of large lowland river channels, floodplains and swamps, NFFs thrive in astonishing abundance and diversity. NFFs in fact represent the most species-rich – and species-dense – continental fauna on Earth. Recent years have also seen rapid increase in our knowledge of the phylogenetic and ecological dimensions of NFF diversity, and the adoption of many innovative methods to study and understand the historical ecology of this singular fauna. NFF species inhabit a broad range of aquatic habitats, ecoregions and climate zones, displaying a bewildering array of organismal phenotypes that potentially confer functional advantages. Many NFFs possess ecophysiological and behavioral traits and tolerances that promote co-existence in species-rich local assemblages, some of which may also enhance evolutionary diversification. Other specialized phenotypes of sexual communication systems, including sensory cues and courtship displays, inhibit species from hybridizing and therefore promote higher species richness of local assemblages. The goals of this book are to synthesize current information on the historical ecology of NFF taxa, and to document the phylogenetic history of the many distinctive ecophysiological phenotypes of these fishes adapted to diverse habitat, dietary and other life-history specializations.

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Conference / Symposium Fri, 24 Jan 2020 10:54:51 -0500 2020-01-31T14:00:00-05:00 2020-01-31T15:00:00-05:00 Research Museums Center Ecology and Evolutionary Biology Conference / Symposium Graphic of freshwater fish
Biodiversity Lab Chat (February 1, 2020 3:30pm) https://events.umich.edu/event/69903 69903-17758055@events.umich.edu Event Begins: Saturday, February 1, 2020 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the Welcome Desk for times.

Stop by and chat with an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world.

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Other Mon, 06 Jan 2020 10:31:16 -0500 2020-02-01T15:30:00-05:00 2020-02-01T15:45:00-05:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
Biodiversity Lab Chat (February 2, 2020 3:30pm) https://events.umich.edu/event/69903 69903-17758060@events.umich.edu Event Begins: Sunday, February 2, 2020 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the Welcome Desk for times.

Stop by and chat with an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world.

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Other Mon, 06 Jan 2020 10:31:16 -0500 2020-02-02T15:30:00-05:00 2020-02-02T15:45:00-05:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
BME Student Speaker: Xiaotian Tan (February 3, 2020 12:00pm) https://events.umich.edu/event/72234 72234-17963872@events.umich.edu Event Begins: Monday, February 3, 2020 12:00pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: Biomedical Engineering

Biosensors are devices or systems that can be used to detect, quantify, and analyze targets with biological activities and functions. As one of the largest subsets of biosensors, biomolecular sensors are specifically developed and programmed to detect, quantify and analyze biomolecules in liquid samples. Wide-ranging applications have made immunoassays increasingly popular for biomolecular detection and quantification. Among these, enzyme-linked immunosorbent assays (ELISA) are of particular interest due to high specificity and reproducibility. To some extent, ELISA has been regarded as a “gold standard” for quantifying analytes (especially protein analytes) in both clinical diagnostics and fundamental biological research. However, traditional (96-well plate-based) ELISA still suffers from several notable drawbacks, such as long assay time (4–6 hours), lengthy procedures, and large sample/reagent consumption (∼100 μL). These inherent disadvantages still significantly limit traditional ELISA's applicability to areas such as rapid clinical diagnosis of acute diseases (e.g., viral pneumonia, acute organ rejection), and biological research that requires accurate measurements with precious or low abundance samples (e.g., tail vein serum from a mouse). Thus, a bimolecular sensing technology that has high sensitivity, short assay time, and small sample/reagent consumption is still strongly desired. In this dissertation, we introduce the development of a multifunctional and automated optofluidic biosensing platform that can resolve the aforementioned problems. In contrast to conventional plate-based ELISA, our optofluidic ELISA platform utilizes mass-producible polystyrene microfluidic channels with a high surface-to-volume ratio as the immunoassay reactors, which greatly shortens the total assay time. We also developed a low-noise signal amplification protocol and an optical signal quantification system that was optimized for the optofluidic ELISA platform. Our optofluidic ELISA platform provides several attractive features such as small sample/reagent consumption (<8 μL), short total assay time (30-45 min), high sensitivity (~1 pg/mL for most markers), and a broad dynamic range (3-4 orders of magnitude). Using these features, we successfully quantified mouse FSH (follicle stimulating hormone) concentration with a single drop of tail vein serum. We also successfully monitored bladder cancer progression in orthotopic xenografted mice with only <50 μL of mouse urine. More excitingly, we achieved highly-sensitive exosome quantification and multiplexed immuno-profiling with <40 ng/mL of total input protein (per assay). These remarkable milestones could not be achieved with conventional plate-based ELISA but were enabled by our unique optofluidic ELISA.

As an emerging member of the bimolecular sensor family, our optofluidic ELISA platform provides a high-performance and cost-effective tool for a plethora of applications, including endocrinal, cancer animal model, cellular biology, and even forensic science research. In the future, this technology platform can also be renovated for clinical applications such as personalized cancer diagnosis/prognosis and rapid point-of-care diagnostics for infectious diseases.

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Lecture / Discussion Thu, 30 Jan 2020 09:19:52 -0500 2020-02-03T12:00:00-05:00 2020-02-03T13:00:00-05:00 Lurie Biomedical Engineering (formerly ATL) Biomedical Engineering Lecture / Discussion Xiaotian Tan
MCDB Remembering the past and rewiring the future: A protein-based inheritance paradigm (February 4, 2020 11:45am) https://events.umich.edu/event/70910 70910-17735215@events.umich.edu Event Begins: Tuesday, February 4, 2020 11:45am
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Faculty Candidate
Host: R. Stockbridge

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Workshop / Seminar Fri, 24 Jan 2020 13:31:02 -0500 2020-02-04T11:45:00-05:00 2020-02-04T12:45:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials and yellow microscope on blue background
EEB Tuesday Lunch Seminar/student evaluation: Using long-term enrichment experiments and existing nutrient gradients to determine the nutrient controls on carbon storage in an understudied seagrass ecosystem (February 4, 2020 12:00pm) https://events.umich.edu/event/69212 69212-17269217@events.umich.edu Event Begins: Tuesday, February 4, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Please join us for our weekly brown bag lunch seminar.

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Workshop / Seminar Fri, 24 Jan 2020 09:26:48 -0500 2020-02-04T12:00:00-05:00 2020-02-04T13:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar underwater cinder block reef and seagrass
RNA Regulation at the Single Molecule Level: From Nuclear Organizations to Molecular Activity- Biological Chemistry Seminar (February 4, 2020 12:00pm) https://events.umich.edu/event/71322 71322-17817082@events.umich.edu Event Begins: Tuesday, February 4, 2020 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Fangyuan Ding, Postdoctoral Fellow at CalTech in the Department of Biology and Biological Engineering, will be presenting the Department of Biological Chemistry seminar on Tuesday February 4th, 2020 at 12pm in North Lecture Hall, MS II.

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Workshop / Seminar Mon, 13 Jan 2020 09:11:30 -0500 2020-02-04T12:00:00-05:00 2020-02-04T13:00:00-05:00 Medical Science Unit II Biological Chemistry Workshop / Seminar Ding Flyer
Science as Art Contest Submission Deadline (February 5, 2020 11:55am) https://events.umich.edu/event/48786 48786-17963888@events.umich.edu Event Begins: Wednesday, February 5, 2020 11:55am
Location: Hatcher Graduate Library
Organized By: Arts at Michigan

Arts at Michigan, ArtsEngine and the Science Learning Center invite you to submit artwork to the 2020 Science as Art exhibition. University of Michigan undergraduate students are invited to submit artwork expressing a scientific principle(s), concept(s), idea(s), process(es), and/or structure(s). The artwork may be visual, literary, musical, video, or performance based. A juried panel using criteria based on both scientific and artistic considerations will choose winning submissions.

Deadline for submissions is Wednesday February 5th!

A number of submissions will be selected for prizes, some of which will be on display and/or performed during the Awards Ceremony and/or displayed in an online Contest Gallery. The entry selected for “Best Overall” will be awarded a cash prize, with smaller cash awards in other categories.

For full information, visit: tinyurl.com/scienceasart2020

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Exhibition Thu, 30 Jan 2020 11:47:29 -0500 2020-02-05T11:55:00-05:00 2020-02-05T23:59:00-05:00 Hatcher Graduate Library Arts at Michigan Exhibition Science as Art logo
Synapse instability and degeneration: Mechanisms (February 5, 2020 12:00pm) https://events.umich.edu/event/72328 72328-17974681@events.umich.edu Event Begins: Wednesday, February 5, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Cathy Collins
Yogesh Wairkar is a collaborator with her group.

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Workshop / Seminar Fri, 31 Jan 2020 14:01:48 -0500 2020-02-05T12:00:00-05:00 2020-02-05T13:00:00-05:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials and microscope
Applications of brain-model technology to study neurodevelopmental disorders (February 6, 2020 9:30am) https://events.umich.edu/event/71730 71730-17877246@events.umich.edu Event Begins: Thursday, February 6, 2020 9:30am
Location: Palmer Commons
Organized By: Cell & Developmental Biology

We are pleased to welcome Cleber Trujillo, Ph.D., to Palmer Commons - Great Lakes South on Thursday, February 6th, 2020.

Hosted by: CDB Recruitment Committee

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Lecture / Discussion Mon, 03 Feb 2020 09:39:56 -0500 2020-02-06T09:30:00-05:00 2020-02-06T10:30:00-05:00 Palmer Commons Cell & Developmental Biology Lecture / Discussion Applications of brain-model technology to study neurodevelopmental disorders - Cleber Trujillo, Ph.D
Temporal Regulation of the Blood-Brain Barrier (February 6, 2020 11:45am) https://events.umich.edu/event/70911 70911-17735216@events.umich.edu Event Begins: Thursday, February 6, 2020 11:45am
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Faculty Candidate
Host: G. Csankovszki & Wilinski

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Workshop / Seminar Fri, 24 Jan 2020 13:28:56 -0500 2020-02-06T11:45:00-05:00 2020-02-06T12:45:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials and yellow microscope on blue background
Surfing the Secretory Pathway (February 6, 2020 3:00pm) https://events.umich.edu/event/72331 72331-17974682@events.umich.edu Event Begins: Thursday, February 6, 2020 3:00pm
Location: Palmer Commons
Organized By: Department of Molecular, Cellular, and Developmental Biology

Scientist working on Golgi membrane trafficking
This is an event from the Protein Folding Diseases Initiative

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Workshop / Seminar Fri, 31 Jan 2020 14:01:11 -0500 2020-02-06T15:00:00-05:00 2020-02-06T16:00:00-05:00 Palmer Commons Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar
BME 500: Jun Li, Ph.D. (February 6, 2020 4:00pm) https://events.umich.edu/event/70419 70419-17594471@events.umich.edu Event Begins: Thursday, February 6, 2020 4:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

In today’s research we often talk about knowledge-extraction from Big Data, and integration across different scales: molecules, cells, tissues/organs, organisms and their communities. The pursuit of multi-scale synthesis has a long history. For the microscopic world we have largely succeeded in connecting the chemical properties of molecules with the facts of atoms and their constituents and interactions. In epidemiology, many are currently applying linear mixed models to quantify the genetic contribution of disease risks in the general population. By and large, we live with the tacit belief that basic principles, once found, will be simple and elegant, and that we can build Systems Biology from the ground level. This leads to a pointillistic research culture, as when we try to explain the heredity of complex traits by summing up the individual actions of millions of DNA variants, or when we look for the neural basis of behavior by the connectivity and firing patterns of millions of neurons.
I will use this talk to share some thoughts on the emerging appreciation that, in biomedical data science, perhaps the best one can learn is not widely generalizable Mechanisms, but different laws for different scales of organization. There may not be a good chance, and perhaps no need, to "know" a system by brute force accumulation of larger and larger data at the bottom level. Acknowledging the irreducibility of highly-level phenomena in biology and medicine can help us appreciate the distinct methods, norms, and compromises in traditional disciplines, and steer the society's investment towards balanced collection of good data on all levels. By giving up the blind celebration of sample size, we give more attention to new technologies that can measure what was previously inaccessible, and to the next-generation of information science that embraces messy, context-specific models.

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Lecture / Discussion Fri, 31 Jan 2020 15:04:28 -0500 2020-02-06T16:00:00-05:00 2020-02-06T17:00:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Lecture / Discussion BME Logo
EEB Thursday Seminar: Variable immunity and its consequences for parasite dynamics (February 6, 2020 4:00pm) https://events.umich.edu/event/69041 69041-17220022@events.umich.edu Event Begins: Thursday, February 6, 2020 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Infectious disease results from interactions between parasites and susceptible hosts in the environment. For many populations, we have a limited understanding of the mechanisms that shape host susceptibility and how those mechanisms interact with ecological factors to regulate the spread of disease. Focusing on a simple one-host one-parasite system with environmental transmission, I use theoretical and empirical methods to explore the causes and consequences of variable host immunity. I demonstrate how integrating immune defenses into host-parasite interactions can improve our understanding of disease spread in natural systems.

View YouTube video of seminar: https://youtu.be/g2rVoE-lFwM

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Workshop / Seminar Thu, 02 Apr 2020 13:02:51 -0400 2020-02-06T16:00:00-05:00 2020-02-06T17:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Daphnia specimen depicted.
Startup Career Fair (February 7, 2020 12:00pm) https://events.umich.edu/event/72206 72206-17957291@events.umich.edu Event Begins: Friday, February 7, 2020 12:00pm
Location: Duderstadt Center
Organized By: MPowered Entrepreneurship

Startup Career Fair provides students with the opportunity to pursue their passion and get paid for it. From Productiv in San Francisco to Choco from Berlin, world-renowned startups with mission-driven teams are waiting to hire you.

We invite you to join us on February 7 from 12-4pm at the Duderstadt Center on North Campus. Register by February 4th and you'll be entered into a lottery for an invitation to our exclusive networking breakfast with recruiters. Can’t wait to see you #Launch.

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Careers / Jobs Wed, 29 Jan 2020 13:06:39 -0500 2020-02-07T12:00:00-05:00 2020-02-07T16:00:00-05:00 Duderstadt Center MPowered Entrepreneurship Careers / Jobs #Launch
Biodiversity Lab Chat (February 8, 2020 3:30pm) https://events.umich.edu/event/69903 69903-17758056@events.umich.edu Event Begins: Saturday, February 8, 2020 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the Welcome Desk for times.

Stop by and chat with an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world.

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Other Mon, 06 Jan 2020 10:31:16 -0500 2020-02-08T15:30:00-05:00 2020-02-08T15:45:00-05:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
Biodiversity Lab Chat (February 9, 2020 3:30pm) https://events.umich.edu/event/69903 69903-17758061@events.umich.edu Event Begins: Sunday, February 9, 2020 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the Welcome Desk for times.

Stop by and chat with an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world.

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Other Mon, 06 Jan 2020 10:31:16 -0500 2020-02-09T15:30:00-05:00 2020-02-09T15:45:00-05:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
Chromatin control of cell size & embryonic development (February 10, 2020 9:30am) https://events.umich.edu/event/71736 71736-17877250@events.umich.edu Event Begins: Monday, February 10, 2020 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

We are pleased to welcome Amanda Amodeo, Ph.D. to the Kahn Auditorium of BSRB on Monday, February 10th, 2020.

Hosted by: CDB Recruitment Committee

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Lecture / Discussion Mon, 03 Feb 2020 09:39:19 -0500 2020-02-10T09:30:00-05:00 2020-02-10T10:30:00-05:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion Chromatin control of cell size & embryonic development - Amanda Amodeo, Ph.D.
EEB Tuesday Lunch Seminar: Living in community: microbial eco-evolutionary dynamics (February 11, 2020 12:00pm) https://events.umich.edu/event/69215 69215-17269220@events.umich.edu Event Begins: Tuesday, February 11, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Please join us for our weekly brown bag lunch seminar.

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Workshop / Seminar Wed, 05 Feb 2020 16:01:59 -0500 2020-02-11T12:00:00-05:00 2020-02-11T13:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar magnified view of microbes
Mechanobiology of Nuclear Envelope Junctions- Department of Biological Chemistry Seminar (February 11, 2020 12:00pm) https://events.umich.edu/event/72692 72692-18059647@events.umich.edu Event Begins: Tuesday, February 11, 2020 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Megan King, Associate Professor of Cell Biology at Yale School of Medicine, will be presenting a seminar in the Department of Biological Chemistry on Tuesday February 11th, 2020 at 12noon in North Lecture Hall, MS II

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Workshop / Seminar Mon, 10 Feb 2020 10:05:16 -0500 2020-02-11T12:00:00-05:00 2020-02-11T13:00:00-05:00 Medical Science Unit II Biological Chemistry Workshop / Seminar King
Bioethics Discussion: Love (February 11, 2020 7:00pm) https://events.umich.edu/event/52726 52726-12974160@events.umich.edu Event Begins: Tuesday, February 11, 2020 7:00pm
Location: Lurie Biomedical Engineering
Organized By: The Bioethics Discussion Group

A discussion on the chemistry of our biology.

Readings to consider:
1. The Neurobiology of Love
2. The Medicalization of Love
3. Self-Transcendence, the True Self, and Self-Love
4. Love yourself: The relationship of the self with itself in popular self-help texts

For more information and/or to receive a copy of the readings contact Barry Belmont at belmont@umich.edu or visit http://belmont.bme.umich.edu/bioethics-discussion-group/discussions/040-love/.

You might love the blog: https://belmont.bme.umich.edu/incidental-art/

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Lecture / Discussion Thu, 09 Jan 2020 09:56:11 -0500 2020-02-11T19:00:00-05:00 2020-02-11T20:30:00-05:00 Lurie Biomedical Engineering The Bioethics Discussion Group Lecture / Discussion Love
BME Ph.D Defense: Xiaotian Tan (February 12, 2020 11:00am) https://events.umich.edu/event/72235 72235-17963874@events.umich.edu Event Begins: Wednesday, February 12, 2020 11:00am
Location: Cooley Building
Organized By: Biomedical Engineering

Biosensors are devices or systems that can be used to detect, quantify, and analyze targets with biological activities and functions. As one of the largest subsets of biosensors, biomolecular sensors are specifically developed and programmed to detect, quantify and analyze biomolecules in liquid samples.

Wide-ranging applications have made immunoassays increasingly popular for biomolecular detection and quantification. Among these, enzyme-linked immunosorbent assays (ELISA) are of particular interest due to high specificity and reproducibility. To some extent, ELISA has been regarded as a “gold standard” for quantifying analytes (especially protein analytes) in both clinical diagnostics and fundamental biological research. However, traditional (96-well plate-based) ELISA still suffers from several notable drawbacks, such as long assay time (4–6 hours), lengthy procedures, and large sample/reagent consumption (∼100 μL). These inherent disadvantages still significantly limit traditional ELISA's applicability to areas such as rapid clinical diagnosis of acute diseases (e.g., viral pneumonia, acute organ rejection), and biological research that requires accurate measurements with precious or low abundance samples (e.g., tail vein serum from a mouse). Thus, a bimolecular sensing technology that has high sensitivity, short assay time, and small sample/reagent consumption is still strongly desired.

In this dissertation, we introduce the development of a multifunctional and automated optofluidic biosensing platform that can resolve the aforementioned problems. In contrast to conventional plate-based ELISA, our optofluidic ELISA platform utilizes mass-producible polystyrene microfluidic channels with a high surface-to-volume ratio as the immunoassay reactors, which greatly shortens the total assay time. We also developed a low-noise signal amplification protocol and an optical signal quantification system that was optimized for the optofluidic ELISA platform.

Our optofluidic ELISA platform provides several attractive features such as small sample/reagent consumption (<8 µL), short total assay time (30-45 min), high sensitivity (~1 pg/mL for most markers), and a broad dynamic range (3-4 orders of magnitude). Using these features, we successfully quantified mouse FSH (follicle stimulating hormone) concentration with a single drop of tail vein serum. We also successfully monitored bladder cancer progression in orthotopic xenografted mice with only <50 µL of mouse urine. More excitingly, we achieved highly-sensitive exosome quantification and multiplexed immuno-profiling with <40 ng/mL of total input protein (per assay). These remarkable milestones could not be achieved with conventional plate-based ELISA but were enabled by our unique optofluidic ELISA.

As an emerging member of the bimolecular sensor family, our optofluidic ELISA platform provides a high-performance and cost-effective tool for a plethora of applications, including endocrinal, cancer animal model, cellular biology, and even forensic science research. In the future, this technology platform can also be renovated for clinical applications such as personalized cancer diagnosis/prognosis and rapid point-of-care diagnostics for infectious diseases.

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Lecture / Discussion Thu, 30 Jan 2020 09:28:04 -0500 2020-02-12T11:00:00-05:00 2020-02-12T12:00:00-05:00 Cooley Building Biomedical Engineering Lecture / Discussion Xiaotian Tan
Establishing and Protecting the Integrity of the Nuclear Compartment- Department of Biological Chemistry Seminar (February 12, 2020 12:30pm) https://events.umich.edu/event/72693 72693-18059648@events.umich.edu Event Begins: Wednesday, February 12, 2020 12:30pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Patrick Lusk, Associate Professor of Cell Biology at Yale School of Medicine, will be presenting a seminar in the Department of Biological Chemistry on Wednesday February 12th, 2020 at 12:30pm in North Lecture Hall, MS II

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Workshop / Seminar Mon, 10 Feb 2020 10:07:59 -0500 2020-02-12T12:30:00-05:00 2020-02-12T13:30:00-05:00 Medical Science Unit II Biological Chemistry Workshop / Seminar Lusk
Department of Computational Medicine & Bioinformatics (DCMB) Weekly Seminar (February 12, 2020 4:00pm) https://events.umich.edu/event/72535 72535-18015945@events.umich.edu Event Begins: Wednesday, February 12, 2020 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract:
Normal mechanical function of the heart requires that ATP be continuously synthesized at a hydrolysis potential of roughly -60 kJ mol-1. Yet in both the aging and diseased heart the relationships between cardiac work rate and concentrations of ATP, ADP, and inorganic phosphate are altered. Important outstanding questions are: To what extent do changes in metabolite concentrations that occur in aging and heart disease affect metabolic/molecular processes in the myocardium? How are systolic and diastolic functions affected by changes in metabolite concentrations? Does metabolic energy supply represent a limiting factor in determining physiological maximal cardiac power output and exercise capacity? Does the derangement of cardiac energetics that occurs with heart failure cause exercise intolerance?

To answer these questions, we have developed a multi-physics multi-scale model of cardiac energy metabolism and cardiac mechanics that simulates the dependence of myocardial ATP demand on muscle dynamics and the dependence of muscle dynamics on cardiac energetics. Model simulations predict that the maximal rate at which ATP can be synthesized at free energies necessary to drive physiological mechanical function determine maximal heart rate, cardiac output, and cardiac power output in exercise. Furthermore, we find that reductions in cytoplasmic adenine nucleotide, creatine, and phosphate pools that occur with aging impair the myocardial capacity to synthesize ATP at physiological free energy levels, and that the resulting changes to myocardial energetic status play a causal role in contributing to reductions in maximal cardiac power output with aging. Finally, model predictions reveal that reductions in cytoplasmic metabolite pools contribute to energetic dysfunction in heart failure, which in turn contributes to causing systolic dysfunction in heart failure.

BlueJeans Livestream Link: https://primetime.bluejeans.com/a2m/live-event/rbuvycdc

3:45 p.m. - Light Refreshments served in Forum Hall Atrium
4:00 p.m. - Lecture in Forum Hall

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Lecture / Discussion Wed, 05 Feb 2020 08:41:29 -0500 2020-02-12T16:00:00-05:00 2020-02-12T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
Building the Oligodendrocyte: Mechanisms of Acentrosomal Microtubule Nucleation and mRNA Transport (February 13, 2020 9:30am) https://events.umich.edu/event/71737 71737-17877251@events.umich.edu Event Begins: Thursday, February 13, 2020 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

We are please to welcome Meng-meng Fu, Ph.D., to the Kahn Auditorium in BSRB on February 13th, 2020.

Hosted by: CDB Recruitment Committee and Center for RNA Biomedicine Recruitment Committee

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Lecture / Discussion Mon, 03 Feb 2020 09:37:18 -0500 2020-02-13T09:30:00-05:00 2020-02-13T10:30:00-05:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion Building the Oligodendrocyte: Mechanisms of Acentrosomal Microtubule Nucleation and mRNA Transport - Meng-meng Fu, Ph.D.
Revealing Principles of Subcellular RNA Localization (February 13, 2020 2:00pm) https://events.umich.edu/event/70912 70912-17735217@events.umich.edu Event Begins: Thursday, February 13, 2020 2:00pm
Location: Palmer Commons
Organized By: Department of Molecular, Cellular, and Developmental Biology

Faculty Candidate
Host: A. Wierzbicki and the Life Sciences Institute

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Workshop / Seminar Tue, 28 Jan 2020 11:22:53 -0500 2020-02-13T14:00:00-05:00 2020-02-13T15:00:00-05:00 Palmer Commons Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials and yellow microscope on blue background
BME 500: Leyuan Ma, Ph.D. (February 13, 2020 4:00pm) https://events.umich.edu/event/70420 70420-17594472@events.umich.edu Event Begins: Thursday, February 13, 2020 4:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Chimeric antigen receptor (CAR) T-cell therapy has shown dramatic clinical responses in hematologic malignancies, with a high proportion of durable complete remissions elicited in leukemia and lymphomas. However, achieving the full promise of CAR T-cell therapy, especially in solid tumors, will require further advances in this form of cellular therapy. A key challenge is maintaining a sufficient pool of functional CAR T cells in vivo. We recently developed a strategy to target vaccines to lymph nodes, by linking peptide antigens to albumin-binding phospholipid-polymers. Constitutive trafficking of albumin from blood to lymph makes it ideal chaperone to concentrate these “amphiphile-vaccine” molecules in lymph nodes that would otherwise be rapidly dispersed in the bloodstream following parenteral injection. These lipid-polymer conjugates also exhibit the property that they insert in cell membranes on arrival in lymph nodes. Here, we generated amphiphile CAR T ligand (amph-ligand) vaccine by exploiting these dual lymph node targeting and membrane-decorating properties to repeatedly expand and rejuvenate CAR T cells through the chimeric receptor in native lymph node microenvironment. We evaluated this approach in the presence of a complete host immune system. Amph-ligand vaccine boosting triggered massive CAR T expansion, increased donor cell polyfunctionality, and enhanced anti-tumor efficacy in multiple immunocompetent tumor models. We demonstrate two approaches to generalize this strategy to any CAR, enabling this simple HLA-independent vaccination approach to enhance CAR T functionality to be applied to existing CAR T cell designs. Taken together, our amph-ligand vaccine provides a simple engineering solution to augment CAR T-cell therapy.

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Lecture / Discussion Fri, 07 Feb 2020 13:11:56 -0500 2020-02-13T16:00:00-05:00 2020-02-13T17:00:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Lecture / Discussion BME Logo
Ace Your Courses: Metacognition is Key! (February 13, 2020 5:00pm) https://events.umich.edu/event/70903 70903-17735208@events.umich.edu Event Begins: Thursday, February 13, 2020 5:00pm
Location: Undergraduate Science Building
Organized By: Science Learning Center

Have you ever found yourself putting forth a great deal of effort into your courses, but not feeling like you are actually learning or are left unsatisfied with your grade? This workshop, based on the work of Dr. Saundra Yancy McGuire, will enable you to analyze your current learning strategies, understand exactly what changes you need to implement to earn an A in your courses, identify concrete strategies to use during the remainder of your semester, and become a more efficient learner.

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Workshop / Seminar Wed, 15 Jan 2020 10:19:28 -0500 2020-02-13T17:00:00-05:00 2020-02-13T18:30:00-05:00 Undergraduate Science Building Science Learning Center Workshop / Seminar Teach Yourself How to Learn by Dr. Saundra Yancy McGuire
EEB Museums Friday Seminar - How do quantitative genetics enhance our understanding of morphological evolution (February 14, 2020 2:00pm) https://events.umich.edu/event/72448 72448-18007182@events.umich.edu Event Begins: Friday, February 14, 2020 2:00pm
Location: Off Campus Location
Organized By: Ecology and Evolutionary Biology

Evolutionary quantitative genetics provides a strong theoretical framework for connecting evolutionary processes, the underlying genetic architecture of traits, described in terms of variances and covariances, and the pace and direction of multivariate evolution. In this talk I will discuss the importance of considering a multidimensional phenotype and the within-species (co)variation to understand trait dynamics in populations, in terms of evolvability (i.e., the ability of a biological system to respond to selection) and evolutionary constraints. I will explore the evolution of the cranial covariance structure and the average morphology in the most noteworthy example of adaptive radiation in mammals, the New World leaf-nosed bats, by combining phylogenetic comparative methods and quantitative genetic approaches.

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Presentation Tue, 04 Feb 2020 10:48:15 -0500 2020-02-14T14:00:00-05:00 2020-02-14T15:00:00-05:00 Off Campus Location Ecology and Evolutionary Biology Presentation Details of event
Biodiversity Lab Chat (February 15, 2020 3:30pm) https://events.umich.edu/event/69903 69903-17758057@events.umich.edu Event Begins: Saturday, February 15, 2020 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the Welcome Desk for times.

Stop by and chat with an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world.

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Other Mon, 06 Jan 2020 10:31:16 -0500 2020-02-15T15:30:00-05:00 2020-02-15T15:45:00-05:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
Biodiversity Lab Chat (February 16, 2020 3:30pm) https://events.umich.edu/event/69903 69903-17758062@events.umich.edu Event Begins: Sunday, February 16, 2020 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the Welcome Desk for times.

Stop by and chat with an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world.

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Other Mon, 06 Jan 2020 10:31:16 -0500 2020-02-16T15:30:00-05:00 2020-02-16T15:45:00-05:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
Fighting to Build a Wall: How Cell Competition Shapes Morphogenesis in Mammalian Skin (February 17, 2020 9:30am) https://events.umich.edu/event/71738 71738-17877253@events.umich.edu Event Begins: Monday, February 17, 2020 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

We are pleased to welcome Stephanie J. Ellis, Ph.D., to the Kahn Auditorium in BSRB on Monday, February 17, 2020.

Hosted by: CDB Recruitment Committee

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Lecture / Discussion Mon, 03 Feb 2020 09:48:48 -0500 2020-02-17T09:30:00-05:00 2020-02-17T10:30:00-05:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion Fighting to Build a Wall: How Cell Competition Shapes Morphogenesis in Mammalian Skin - Stephanie J. Ellis, Ph.D.
EEB dissertation defense: When does gene flow stop? A mechanistic approach to the formation of phylogeographic breaks in nature (February 17, 2020 1:00pm) https://events.umich.edu/event/72023 72023-17914210@events.umich.edu Event Begins: Monday, February 17, 2020 1:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Iris defends her doctoral dissertation

Image credit: Alison Davis Rabosky and Christian Cox

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Presentation Thu, 06 Feb 2020 16:14:16 -0500 2020-02-17T13:00:00-05:00 2020-02-17T14:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Presentation Four sonora snakes curled up near each other, orange with black stripes, white with black stripes, a solid orange and a solid brown
MCIRCC Re-Imagining Critical Care Seminar Series (February 17, 2020 3:00pm) https://events.umich.edu/event/71948 71948-17903306@events.umich.edu Event Begins: Monday, February 17, 2020 3:00pm
Location: North Campus Research Complex Building 10
Organized By: Michigan Center for Integrative Research in Critical Care (MCIRCC)

“Innovation Fundamentals & Opportunities in Critical Care Biomarker Discovery”

Frederick Korley MD, PhD is an Associate Professor of Emergency Medicine.

Dr. Korley's research activities involve translation of novel diagnostics to inform clinically rational, timely, and cost-effective diagnosis of cardiac and brain injury in the emergency department. The goal of his traumatic brain injury work is to improve the acute care diagnosis, risk-stratification and treatment of TBI by identifying distinct molecular subtypes of TBI that will allow for targeted treatment and improved outcomes.

DETAILS & REGISTRATION:
http://bit.ly/FrederickKorley

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Workshop / Seminar Thu, 23 Jan 2020 12:02:33 -0500 2020-02-17T15:00:00-05:00 2020-02-17T16:00:00-05:00 North Campus Research Complex Building 10 Michigan Center for Integrative Research in Critical Care (MCIRCC) Workshop / Seminar MCIRCC Re-Imagining Critical Care Seminar Series with Dr. Frederick K. Korley Flyer
EEB Tuesday Lunch Seminar: Phylogenetic systematics and evolution of the gaudy grasshopper family Pyrgomorphidae (Insecta: Orthoptera) (February 18, 2020 12:00pm) https://events.umich.edu/event/69217 69217-17269221@events.umich.edu Event Begins: Tuesday, February 18, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Please join us for our weekly brown bag lunch seminar.

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Workshop / Seminar Mon, 10 Feb 2020 13:48:00 -0500 2020-02-18T12:00:00-05:00 2020-02-18T13:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar grasshopper with striped body (bluish green and gold stripes over black with red appendanges and orange and black flecked wings) sitting outside with grass in background
The Role of Citrullination in Rheumatoid Arthritis- Department of Biological Chemistry Seminar (February 18, 2020 12:00pm) https://events.umich.edu/event/72694 72694-18059649@events.umich.edu Event Begins: Tuesday, February 18, 2020 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Ronak Tilvawala, Postdoctoral Associate at U-Mass Medical School, will be presenting a seminar in the Department of Biological Chemistry on Tuesday February 18th, 2020 at 12noon in North Lecture Hall, MS II

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Workshop / Seminar Mon, 10 Feb 2020 10:14:08 -0500 2020-02-18T12:00:00-05:00 2020-02-18T13:00:00-05:00 Medical Science Unit II Biological Chemistry Workshop / Seminar
Seminar: Dissecting mechanisms that govern cellular plasticity (February 18, 2020 2:00pm) https://events.umich.edu/event/72743 72743-18070547@events.umich.edu Event Begins: Tuesday, February 18, 2020 2:00pm
Location: Palmer Commons
Organized By: Life Sciences Institute (LSI)

Speaker:

Bruno Di Stefano, Ph.D.
Massachusetts General Hospital, Harvard Medical School, Harvard Stem Cell Institute

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Workshop / Seminar Tue, 11 Feb 2020 13:48:43 -0500 2020-02-18T14:00:00-05:00 2020-02-18T15:00:00-05:00 Palmer Commons Life Sciences Institute (LSI) Workshop / Seminar Life Sciences Institute logo
Genetics Training Program / CMB Short Course (630) (February 18, 2020 3:00pm) https://events.umich.edu/event/72320 72320-17974673@events.umich.edu Event Begins: Tuesday, February 18, 2020 3:00pm
Location: Medical Science Unit II
Organized By: Department of Human Genetics

Welcome to the Exciting World of Tandem and Interspersed DNA Repeat Elements
Presented By Jayakrishnan Nandakumar, Ph.D.
Associate Professor
Department of Molecular, Cellular, and Developmental Biology University of Michigan Medical School
Tuesday, February 18, 2020
3:00 p.m.
West Lecture Hall, Med Sci II

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Lecture / Discussion Fri, 31 Jan 2020 13:25:19 -0500 2020-02-18T15:00:00-05:00 2020-02-18T16:00:00-05:00 Medical Science Unit II Department of Human Genetics Lecture / Discussion Nandakumar GTP / CMB Short Course Flyer
“Modulating kidney development: from cells to signals and transcriptional regulation” (February 18, 2020 4:00pm) https://events.umich.edu/event/71238 71238-17794026@events.umich.edu Event Begins: Tuesday, February 18, 2020 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for Cell Plasticity and Organ Design

The NIH T32 Training Program in Organogenesis is pleased to present a Special Series: "Emerging Topics in Tissue Regeneration and Engineering" featuring seminar guest Lori O'Brien, Ph.D.

Dr. O'Brien is an Assistant Professor, Department of Cell Biology and Physiology
UNC Kidney Center from the University of North Carolina.

The talk is entitled, “Modulating kidney development: from cells to signals and transcriptional regulation”.

Trainee Host: Rosa Menijvar, Ph.D. Candidate- Pasca di Magliano Lab

For additional info: 936-2499 / organogenesis@umich.edu

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Lecture / Discussion Fri, 10 Jan 2020 12:12:36 -0500 2020-02-18T16:00:00-05:00 2020-02-18T17:00:00-05:00 Taubman Biomedical Science Research Building Center for Cell Plasticity and Organ Design Lecture / Discussion Flyer
EEB + MCDB Pizza with Professors (February 19, 2020 4:00pm) https://events.umich.edu/event/61938 61938-18015957@events.umich.edu Event Begins: Wednesday, February 19, 2020 4:00pm
Location: Biological Sciences Building
Organized By: Program in Biology

Join faculty, graduate students, and fellow EEB- & MCDB-interested students for pizza and conversation!

Please RSVP here: http://www.tinyurl.com/biologypizza

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Social / Informal Gathering Wed, 05 Feb 2020 10:35:49 -0500 2020-02-19T16:00:00-05:00 2020-02-19T18:00:00-05:00 Biological Sciences Building Program in Biology Social / Informal Gathering Pizza
No Defense: The U.S. Government's War on Water (February 19, 2020 7:00pm) https://events.umich.edu/event/72213 72213-17957434@events.umich.edu Event Begins: Wednesday, February 19, 2020 7:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

In conjunction with the Feb 20 symposium, "From PBB to PFAS: Research and Action to Address Michigan’s Large-Scale Chemical Contaminations" this FREE event is sponsored by the National Wildlife Foundation and the Michigan League of Conservation Voters.

"No Defense" is a documentary that tells the story of the Americans who are fighting against one of the largest-known polluters in the country — the United States government. Since the 1990s, it’s been documented that a category of chemicals known as perfluorinated compounds (PFAS) are harmful to life, yet the government continues to mandate its use at hundreds of sites across the country, contaminating surface water and drinking water, with no plan in place to clean it up. This film highlights the people who are suffering, who are blowing the whistle, and who are fighting the United States military’s war on water.

The film focuses on the PFAS contamination problem in Oscoda, Michigan, as a case study into how the U.S. military has failed to protect human health and the environment around the nation and the world. The PFAS contamination in Oscoda was discovered nearly 10 years ago, making it the first PFAS site in Michigan and the first PFAS military site in the world. The film's director, Sara Ganim, is a former CNN correspondent who won the Pulitzer Prize for breaking the Jerry Sandusky sex abuse scandal at Penn State; she also has done extensive reporting on water issues in other communities in the U.S, including Flint.

Documentary. 270 min. Including Filmmaker Q&A. NR.

No Defense is directed by Pulitzer-Prize winning journalist Sara Ganim. Produced by Emmy-award winning journalist Lennart Bourin. Executive Producer Robert P. Ufer.

Film will be followed by a Filmmaker Q&A.

*Admission is free, but you're encouraged to reserve tickets at this link: https://bit.ly/2RUYYWU

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Film Screening Thu, 30 Jan 2020 15:29:58 -0500 2020-02-19T19:00:00-05:00 2020-02-19T21:00:00-05:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Film Screening No Defense: The US Government's War on Water (PFAS documentary)
From PBB to PFAS: Research and Action to Address Michigan’s Large Scale Chemical Contaminations (February 20, 2020 9:00am) https://events.umich.edu/event/68807 68807-17153411@events.umich.edu Event Begins: Thursday, February 20, 2020 9:00am
Location: Michigan League
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

The PBB to PFAS Symposium will provide a unique venue for fostering collaboration between researchers and community members with:

• Keynote address by Dr. Linda Birnbaum (Director NIEHS, retired);

• Presentations by community residents and academic researchers working on PBB and PFAS health impacts;

• Breakout groups focused on strategies for building effective community-academic collaborations;

• Organized by UM's Center on Lifestage Environmental Exposures and Disease (M-LEEaD), Central Michigan University's Dept of History, Liberal Arts & Social Sciences, Emory University’s HERCULES Exposome Research Center;

• ADDITIONAL SPEAKERS: Michele Marcus, PhD, Emory University’s Michigan PBB Registry; Jane Keon, Pine River Superfund Citizen Task Force; Francis Spaniola, former Michigan State Representative; Tony Spaniola, JD, creator Michigan Cancer Registry; Courtney Carignan, PhD, Michigan State University; Monica Lewis-Patrick, President & CEO, River Network and We The People of Detroit

• COMMUNITY PANELISTS: Sandy Wynn-Stelt, Rockford; Theresa Landrum, Detroit; Lawrence Reynolds, Flint; Donele Wilkins, Detroit; Tim Neyer, Mt. Pleasant

• MORE SPEAKERS AND BREAKOUT SESSIONS TO BE ANNOUNCED

• Keynote address by Dr. Birnbaum will be livestreamed.

• Registration (free) is required.

• Register for the IN-PERSON Event in Ann Arbor: http://mleead.umich.edu/Event_FromPBBtoPFAS_Register.php?Attendance=InPerson
OR
• Register for the Keynote LIVESTREAM: http://mleead.umich.edu/Event_FromPBBtoPFAS_Register.php?Attendance=LiveStream

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Conference / Symposium Fri, 24 Jan 2020 16:21:01 -0500 2020-02-20T09:00:00-05:00 2020-02-20T16:00:00-05:00 Michigan League Michigan Lifestage Environmental Exposures and Disease Center Conference / Symposium PBB to PFAS symposium Feb 20 2020
BME Ph.D. Defense: Lauren L. Zimmerman (February 20, 2020 10:00am) https://events.umich.edu/event/72566 72566-18018159@events.umich.edu Event Begins: Thursday, February 20, 2020 10:00am
Location: Lurie Robert H. Engin. Ctr
Organized By: Biomedical Engineering

Department of Biomedical Engineering Final Oral Examination

Lauren L. Zimmerman

Investigating Neuromodulation as a Treatment for Female Sexual Dysfunction

Female sexual dysfunction (FSD) affects millions of women worldwide. FSD has a significant impact on quality of life and interpersonal relationships. The prevalence of at least one form of sexual dysfunction is 40-45% of adult women with 12% of women experiencing sexually related personal distress, yet there is no clear treatment option for a wide range of FSD deficits with high efficacy and low side effects.

Neuromodulation techniques using electrical stimulation of peripheral nerves have the potential to treat some forms of FSD. In clinical trials of sacral neuromodulation (SNM) and percutaneous tibial nerve stimulation (PTNS) for bladder dysfunction, women have reported that their sexual dysfunction symptoms improved as well. Even though this effect has been observed clinically, very little research has been done to examine the mechanisms or the optimal method of treatment specifically for women with FSD. This thesis aims to bridge that gap by investigating neuromodulation as a treatment for FSD through both preclinical and clinical studies.

The first aim of this thesis is to investigate a possible mechanism of the improvement to sexual functioning in response to tibial nerve stimulation by evaluating vaginal blood flow responses in rats. In 16 ketamine-anesthetized female rats, the tibial nerve was stimulated for 30 minutes while vaginal blood perfusion was recorded with laser Doppler flowmetry. A novel signal analysis and quantification metric was developed for this analysis. I found that tibial nerve stimulation could drive prolonged increases in vaginal blood perfusion, typically after 20-30 minutes of stimulation. This result suggests that clinical neuromodulation may be improving FSD symptoms by increasing genital blood flow.

One question yet to be investigated by neuromodulation studies is whether tibial nerve stimulation could be an on-demand treatment for FSD, such as Viagra is for men, or is more appropriate as a long-term treatment with improvements over time, such as PTNS for bladder dysfunction. In this thesis I address this question by evaluating the sexual motivation and receptivity of female rats both immediately after a single stimulation session as well as after long-term, repeated stimulation sessions. I found that tibial nerve stimulation led to modest increases in sexual motivation in the short term, and larger increases in sexual receptivity in the long-term.

Lastly, this thesis evaluates a pilot clinical study of transcutaneous stimulation of the dorsal genital and posterior tibial nerves in nine women with FSD. The women received stimulation once a week for 12 weeks and their sexual functioning was measured using the Female Sexual Function Index (FSFI) at baseline, after 6 weeks of stimulation, after 12 weeks of stimulation, and at 18 weeks (6 weeks after the last stimulation session). The average total FSFI score across all subjects significantly increased from baseline to each of the time points in the study. Significant FSFI increases were seen in the sub-domains of lubrication, arousal, and orgasm, each of which is related to genital arousal.

This thesis provides evidence that peripheral neuromodulation can be an effective treatment for FSD. The stimulation is likely driving increases in genital blood flow, with greater effects observed when stimulation is repeatedly applied over time. This treatment has the potential to help millions of women worldwide.

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Lecture / Discussion Wed, 05 Feb 2020 15:00:05 -0500 2020-02-20T10:00:00-05:00 2020-02-20T11:00:00-05:00 Lurie Robert H. Engin. Ctr Biomedical Engineering Lecture / Discussion BME Logo
Microfluidics Seminar: Dr. Xufeng Xue (February 20, 2020 12:00pm) https://events.umich.edu/event/73026 73026-18129602@events.umich.edu Event Begins: Thursday, February 20, 2020 12:00pm
Location: Pierpont Commons
Organized By: Biomedical Engineering

Neurulation is a key embryonic developmental process that gives rise to neural tube (NT), the precursor structure that eventually develops into the central nervous system (CNS). Understanding the molecular mechanisms and morphogenetic events underlying human neurulation is important for the prevention and treatment of neural tube defects (NTDs) and neurodevelopmental disorders. However, animal models are limited in revealing many fundamental aspects of neurulation that are unique to human CNS development. Furthermore, the technical difficulty and ethical constraint in accessing neurulation-stage human embryos have significantly limited experimental investigations of early human CNS development.
I leveraged the developmental potential and self-organizing property of human pluripotent stem cells (hPSCs) in conjunction with 2D and 3D bioengineering tools to achieve the development of spatially patterned multicellular tissues that mimic certain aspects of human neurulation, including neuroectoderm patterning and dorsal-ventral (DV) patterning of NT.
In the first section, I report a micropatterned hPSC-based neuroectoderm model, wherein pre-patterned geometrical confinement induces emergent patterning of neuroepithelial (NE) and neural plate border (NPB) cells, mimicking neuroectoderm patterning during early neurulation. My data support the hypothesis that in this hPS cell-based neuroectoderm patterning model, two tissue-scale morphogenetic signals, cell shape and cytoskeletal contractile force, instruct NE / NPB patterning via BMP-SMAD signaling. This work provides evidence of tissue mechanics-guided neuroectoderm patterning and establishes a tractable model to study signaling crosstalk involving both biophysical and biochemical determinants in neuroectoderm patterning.
In the second section, I report a human NT development model, in which NT-like tissues, termed NE cysts, are generated in a bioengineered neurogenic environment through self-organization of hPSCs. DV patterning of NE cysts is achieved using retinoic acid and/or Sonic Hedgehog, featuring sequential emergence of the ventral floor plate, p3 and pMN domains in discrete, adjacent regions and dorsal territory that is progressively restricted to the opposite dorsal pole.

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Lecture / Discussion Tue, 18 Feb 2020 08:58:46 -0500 2020-02-20T12:00:00-05:00 2020-02-20T13:00:00-05:00 Pierpont Commons Biomedical Engineering Lecture / Discussion BME Logo
Seminar: Targeting tumor-immune interplays (February 20, 2020 2:00pm) https://events.umich.edu/event/72744 72744-18070548@events.umich.edu Event Begins: Thursday, February 20, 2020 2:00pm
Location: Palmer Commons
Organized By: Life Sciences Institute (LSI)

Speaker
Peiwen Chen, Ph.D.
University of Texas, MD Anderson Cancer Center

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Workshop / Seminar Tue, 11 Feb 2020 13:50:46 -0500 2020-02-20T14:00:00-05:00 2020-02-20T15:00:00-05:00 Palmer Commons Life Sciences Institute (LSI) Workshop / Seminar Life Sciences Institute logo
BME 500: Ruixuan Gao (February 20, 2020 4:00pm) https://events.umich.edu/event/70421 70421-17594473@events.umich.edu Event Begins: Thursday, February 20, 2020 4:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Investigation of the molecular basis of a complex biological system, such as the brain, can lead to fundamental understanding of its composition and function, and to a new strategy to repair it. Such investigation, however, requires a tool that can capture biological structures and their molecular constituents across multiple orders of magnitude—from nanometers to centimeters—in length. Electron microscopy offers nanoscopic resolution but lacks molecular information to differentiate endogenous biomolecules as well as imaging speed to cover millimeter-scale specimens. Light microscopy provides molecular contrast but is limited by optical diffraction and the tradeoff between imaging speed and photobleaching.

In this talk, I will first introduce an optical imaging pipeline named expansion lattice light-sheet microscopy (ExLLSM) and its application to multiplexed, volumetric imaging of molecular constituents in cells and intact tissues. Using ExLLSM, our study has revealed molecular-specific structures of organelles, synapses, myelin sheaths, and neurites in rodent and insect brains at ∼60 by 60 by 90 nm effective resolution across dimensions that span millimeters. Next, I will present two recently developed methods that further extend the resolution and throughput of ExLLSM: (1) a non-radical hydrogel chemistry that forms a homogenous polymer network and physically separates biomolecules or fluorescent labels up to 40-fold linearly, and (2) a multi-modal optical microscopy that enables rapid, high-resolution imaging of both expanded and live tissues. Lastly, I will discuss the significance of these imaging methods in the context of microanatomy and functional omics.

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Lecture / Discussion Thu, 13 Feb 2020 10:34:18 -0500 2020-02-20T16:00:00-05:00 2020-02-20T17:00:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Lecture / Discussion BME Logo
EEB Thursday Seminar: Approaches to diversifying who does Ecology & Evolution: from undergraduate to faculty (February 20, 2020 4:00pm) https://events.umich.edu/event/69043 69043-17220024@events.umich.edu Event Begins: Thursday, February 20, 2020 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

There is a growing body of literature demonstrating the barriers and solutions to improve the successful selection, retention, and development of underrepresented (UR = low income, minority, and first generation) students in ecology and evolutionary biology & STEM fields in general. A model undergraduate training program will be presented that focuses on a growth mindset over traditional skim programs. This will be followed by recommendations for DEI around graduate school selection & training, and the last section of the talk will address on-going approaches to hiring diverse faculty, retention, and ways to establish DEI receipts for all populations.

View YouTube video of seminar: https://youtu.be/GWhJgeJ-kbE

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Workshop / Seminar Thu, 02 Apr 2020 13:04:27 -0400 2020-02-20T16:00:00-05:00 2020-02-20T17:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Corey Welch at Grand Canyon
Medical School Student Panel Discussion (February 20, 2020 5:30pm) https://events.umich.edu/event/72115 72115-17939978@events.umich.edu Event Begins: Thursday, February 20, 2020 5:30pm
Location: Undergraduate Science Building
Organized By: Science Learning Center

Here is your chance to hear about what life is like for several medical school students and residents. Learn about each of their paths to medicine, experiences in medical school, and things they wished they had known in college.

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Workshop / Seminar Mon, 27 Jan 2020 12:42:55 -0500 2020-02-20T17:30:00-05:00 2020-02-20T18:30:00-05:00 Undergraduate Science Building Science Learning Center Workshop / Seminar
MCDB: Epigenetic inheritance mediated by RNA and chromatin (February 21, 2020 12:00pm) https://events.umich.edu/event/71851 71851-17894526@events.umich.edu Event Begins: Friday, February 21, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Györgyi Csankovszki

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Workshop / Seminar Fri, 14 Feb 2020 13:48:39 -0500 2020-02-21T12:00:00-05:00 2020-02-21T13:00:00-05:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Biological Sciences Building
Science as Art Exhibition- Panel discussion & Awards Reception (February 21, 2020 2:00pm) https://events.umich.edu/event/38185 38185-17963890@events.umich.edu Event Begins: Friday, February 21, 2020 2:00pm
Location: Hatcher Graduate Library
Organized By: Arts at Michigan

Arts at Michigan, ArtsEngine and the Science Learning Center invite you to the Science as Art Contest Exhibition and Awards Reception- Hatcher Graduate Library, Rm 100.

2pm Office Hours for participating artists
3pm Panel Discussion & Reception
4pm Awards Announcements


University of Michigan undergraduate students will have artwork on view expressing a scientific principle, concept, idea, process, or structure. The artwork ranges in media, including visual, literary, musical, video and performance-based art. A juried panel using criteria based on both scientific and artistic considerations will choose winning submissions. This is our fourth year of the exhibition, and we received a record number of submissions, so we hope you'll join us to view the work and give out the awards!

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Exhibition Thu, 30 Jan 2020 11:57:18 -0500 2020-02-21T14:00:00-05:00 2020-02-21T16:30:00-05:00 Hatcher Graduate Library Arts at Michigan Exhibition Science as Art logo
Biologist-for-a-Day Outreach Event (February 22, 2020 1:00pm) https://events.umich.edu/event/68867 68867-17842684@events.umich.edu Event Begins: Saturday, February 22, 2020 1:00pm
Location: Biological Sciences Building
Organized By: Biology Outreach Team - BOT

Hands-on activities will demonstrate scientific concepts to families visiting campus. If you are a student and would like to be a part of this or future science outreach events, please contact the Biology Outreach Team (BOT.Contact@umich.edu).

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Community Service Thu, 16 Jan 2020 10:37:44 -0500 2020-02-22T13:00:00-05:00 2020-02-22T15:00:00-05:00 Biological Sciences Building Biology Outreach Team - BOT Community Service An activity station from a recent biology outreach event
Biodiversity Lab Chat (February 22, 2020 3:30pm) https://events.umich.edu/event/69903 69903-17758058@events.umich.edu Event Begins: Saturday, February 22, 2020 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the Welcome Desk for times.

Stop by and chat with an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world.

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Other Mon, 06 Jan 2020 10:31:16 -0500 2020-02-22T15:30:00-05:00 2020-02-22T15:45:00-05:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
Creation Sunday (February 23, 2020 9:45am) https://events.umich.edu/event/72979 72979-18120900@events.umich.edu Event Begins: Sunday, February 23, 2020 9:45am
Location: Off Campus Location
Organized By: Collegians for Christ

Collegians for Christ is excited to partner with Ann Arbor Baptist Church to present a series of thought provoking lectures on the fundamental question: where did everything come from? Come hear the various theories about the origins of the universe. The speaker is Orlando Buria, Ph.D., a sought after scientist and instructor on the topics of universe origins, natural history, and biology. Dr. Buria is a published researcher who will present engaging and thought provoking lectures.

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Lecture / Discussion Mon, 17 Feb 2020 11:56:24 -0500 2020-02-23T09:45:00-05:00 2020-02-23T14:00:00-05:00 Off Campus Location Collegians for Christ Lecture / Discussion Creation Sunday Graphics
Biodiversity Lab Chat (February 23, 2020 3:30pm) https://events.umich.edu/event/69903 69903-17758063@events.umich.edu Event Begins: Sunday, February 23, 2020 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the Welcome Desk for times.

Stop by and chat with an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world.

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Other Mon, 06 Jan 2020 10:31:16 -0500 2020-02-23T15:30:00-05:00 2020-02-23T15:45:00-05:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
Seminar: CRISPR tools for studying and engineering the three-dimensional genome (February 24, 2020 2:00pm) https://events.umich.edu/event/72745 72745-18070549@events.umich.edu Event Begins: Monday, February 24, 2020 2:00pm
Location: Palmer Commons
Organized By: Life Sciences Institute (LSI)

Speaker
Haifeng Wang, PH.D.
Stanford University, Department of Bioengineering

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Workshop / Seminar Tue, 11 Feb 2020 13:52:58 -0500 2020-02-24T14:00:00-05:00 2020-02-24T15:00:00-05:00 Palmer Commons Life Sciences Institute (LSI) Workshop / Seminar Life Sciences Institute logo
Defining microRNAs: How Cells Select Transcripts to Enter the microRNA pathway- Department of Biological Chemistry Seminar (February 25, 2020 12:00pm) https://events.umich.edu/event/71136 71136-17783434@events.umich.edu Event Begins: Tuesday, February 25, 2020 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Wenwen Fang, Postdoctoral Fellow at Whitehead/MIT will be presenting the Department of Biological Chemistry Seminar on Tuesday February 25th, 2020 at 12:00pm in North Lecture Hall, MS II.

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Workshop / Seminar Thu, 09 Jan 2020 06:47:39 -0500 2020-02-25T12:00:00-05:00 2020-02-25T13:00:00-05:00 Medical Science Unit II Biological Chemistry Workshop / Seminar
Defining microRNAs: How Cells Select Transcripts to Enter the microRNA pathway- Department of Biological Chemistry Seminar (February 25, 2020 12:00pm) https://events.umich.edu/event/72695 72695-18059651@events.umich.edu Event Begins: Tuesday, February 25, 2020 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Wenwen Fang, Postdoctoral Fellow at Whitehead Institute/MIT will present a seminar on Tuesday February 25th, 2020 at 12 noon in North Lecture Hall, MS II

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Workshop / Seminar Mon, 10 Feb 2020 10:18:40 -0500 2020-02-25T12:00:00-05:00 2020-02-25T13:00:00-05:00 Medical Science Unit II Biological Chemistry Workshop / Seminar
EEB Tuesday Lunch Seminar: The impact of within-host priority effects on disease dynamics in coinfected populations (February 25, 2020 12:00pm) https://events.umich.edu/event/69218 69218-17269222@events.umich.edu Event Begins: Tuesday, February 25, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Please join us for our weekly brown bag lunch seminar.

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Workshop / Seminar Wed, 19 Feb 2020 17:18:25 -0500 2020-02-25T12:00:00-05:00 2020-02-25T13:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar dentifera under magnification on black background
LHS Collaboratory (February 25, 2020 12:00pm) https://events.umich.edu/event/72208 72208-18035597@events.umich.edu Event Begins: Tuesday, February 25, 2020 12:00pm
Location: 1027 E. Huron Building
Organized By: Department of Learning Health Sciences

"Value Proposition of Learning Health Systems"
Erik Gordon, PhD
Clinical Assistant Professor, Ross School of Business, University of Michigan
Tuesday, February 25, 2020 – 12 pm–1:30 pm
Great Lakes Room, Palmer Commons (Lunch is included)

Professor Gordon's areas of interest are entrepreneurship and technology commercialization, venture capital, private equity, mergers and acquisitions, corporate governance, the biomedical industry (pharmaceuticals, devices, healthcare big data, and biotechnology), IoT, FinTech, and digital and mobile marketing. He also served on the faculty of University of Michigan Law School. He has served on the faculty and as Associate Dean and Director of the Graduate Division of Business & Management (Carey Business School) at Johns Hopkins University, where he taught in the business and medical schools and at the University of Florida, where he also served as director of the Center for Technology & Science Commercialization Studies and as Director of MBA Programs. He has served as an adviser or co-founder to numerous companies. He is frequently quoted in The New York Times, BusinessWeek, The Wall Street Journal, Bloomberg, Reuters and other outlets, is a regular contributor to Marketplace Morning Report (in NPR's Morning Edition), Bloomberg Radio, and appears on PBS's Nightly Business Report. His degrees are in economics and law.
Please register in advance, dlhs-umi.ch/lhs-collaboratory.
Email: LHScollaboratory-info@umich.edu

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Lecture / Discussion Fri, 07 Feb 2020 15:07:52 -0500 2020-02-25T12:00:00-05:00 2020-02-25T13:30:00-05:00 1027 E. Huron Building Department of Learning Health Sciences Lecture / Discussion LHS Collaboratory
“Embryonically Informed Tendon Regeneration Strategies” (February 25, 2020 4:00pm) https://events.umich.edu/event/71239 71239-17794030@events.umich.edu Event Begins: Tuesday, February 25, 2020 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for Cell Plasticity and Organ Design

The NIH T32 Training Program in Organogenesis is pleased to present a Special Series: "Emerging Topics in Tissue Regeneration and Engineering" featuring seminar guest Catherine K. Kuo, Ph.D.

Dr. Kuo is an Associate Professor,of Biomedical Engineering, and Center for Musculoskeletal Research at the University of Rochester.

Trainee Host: Kevin McGowan, Ph.D. Candidate-Samuelson Lab

For additional info: 936-2499 / organogenesis@umich.edu

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Lecture / Discussion Fri, 10 Jan 2020 12:17:45 -0500 2020-02-25T16:00:00-05:00 2020-02-25T17:00:00-05:00 Taubman Biomedical Science Research Building Center for Cell Plasticity and Organ Design Lecture / Discussion Kuo Flyer
CEW+Inspire Workshop: Who Speaks for Seeds? Respectful Listening – Meaningful Actions (February 27, 2020 2:00pm) https://events.umich.edu/event/69928 69928-17483065@events.umich.edu Event Begins: Thursday, February 27, 2020 2:00pm
Location: Center for the Education of Women
Organized By: CEW+

The workshop is from 2-3:30, followed by a networking reception until 4:00.

The concept of Rematriation as Reconciliation is simple. It is the return of living seeds to their Community of Origin. But issues of trust soon emerge. Who is involved in conceptually framing and prioritizing critical thought and action? Who/what Community Members have both standing and agency to be engaged—ethically, spiritually, and legally? Who speaks for Indigenous Nation’s seeds in museum diaspora? What is “listening” when contributing parties’ paradigms of reality are not fully congruent?

This workshop, co-led by Tribal Partner Mede (Elder) Shannon Martin, will address deep listening skills as a key to trust-building. Shannon is the Director of the Ziibiwing Center of Anishinabe Culture & Lifeways in Mount Pleasant, Michigan. The Heritage Seeds Project and how it grew into the Indigenous Collaborative Garden will be one trust-building example. The challenges of deep listening from an academic perspective are real. Participants should become aware that Reconciliation is about fundamental change – in one’s self.

Dr. David C. Michener is the curator at the U-M Matthaei Botanical Gardens and Nichols Arboretum. Best known to the public for his co-authored book Peony, which made the New York Times 2018 Summer Reading List, his research addresses understanding the complex cross-cultural heritages of ornamental peonies and conserving key living specimens. He has an active program in molecular-evidence of peony relationships with colleagues and students here at U-M and in Belarus. His work with Indigenous Seeds in museum collections is an unanticipated intersection of deep engagement with U-M’s Museum Studies Program (Rackham Graduate School) and an ethical concern with the ‘Voice’ of Indigenous Communities in interpreting native plant collections and landscapes stewarded by the Botanical Gardens & Arboretum. Before coming to Michigan, David earned his BA in Botany (UNC-Chapel Hill), and his PhD (Claremont Graduate School) was followed by a NSF-funded postdoc at Harvard’s Arnold Arboretum.

RSVP requested at: cew.umich.edu/events/cewinspire-workshop-who-speaks-for-seeds-respectful-listening-meaningful-actions/

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Workshop / Seminar Wed, 22 Jan 2020 10:58:42 -0500 2020-02-27T14:00:00-05:00 2020-02-27T15:30:00-05:00 Center for the Education of Women CEW+ Workshop / Seminar White man with full beard wearing a brown hat, suit and tie
BME 500: Kelly Stevens (February 27, 2020 4:00pm) https://events.umich.edu/event/70067 70067-17505693@events.umich.edu Event Begins: Thursday, February 27, 2020 4:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

The notion of building artificial human organs has moved from a far-fetched concept to the forefront of regenerative medicine research. While progress is being made, most tissues created to date are simply not large enough to support clinically meaningful functions, and their structural features remain an magnitude coarser in resolution than native tissues. Few organs better represent this challenge than the liver – the largest visceral organ in the human body, in which hepatocytes are aligned in single cell-width structures entangled with vascular and biliary networks. To address this challenge, we are working to develop a portfolio of tools that integrate 3D printing, synthetic biology, and the innate capacity of cells to self-assemble. We are applying these tools to decode the signals that drive tissue assembly during development, and using this information to build scaled artificial tissues that replicate the features of native tissues.

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Workshop / Seminar Thu, 20 Feb 2020 11:04:16 -0500 2020-02-27T16:00:00-05:00 2020-02-27T17:00:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar BME Event
EEB Thursday Seminar: Probing the structure of fitness landscapes with experimental evolution (February 27, 2020 4:00pm) https://events.umich.edu/event/69044 69044-17220025@events.umich.edu Event Begins: Thursday, February 27, 2020 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

The ability to evolve and adapt is a fundamental property of living systems. In many populations, the process of adaptive evolution can be thought of as an uphill walk of a population on a "fitness landscape" where mutations are steps and fitness is altitude. Understanding the structure of fitness landscapes is a fundamental open problem in evolutionary biology. I will discuss our efforts to probe the fitness landscapes and the adaptive walks on them using experimental microbial populations. I will show some interesting and perhaps somewhat counterintuitive patterns that we found. If time permits, I will say a few words about our initial attempts to build a theory that might help us understand these patterns.

View YouTube video of seminar: https://youtu.be/BAMcA5yz8I8

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Workshop / Seminar Fri, 10 Apr 2020 14:13:09 -0400 2020-02-27T16:00:00-05:00 2020-02-27T17:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Dr. Kryazhimskiy image of fitness landscape
MCDB: Synthetic Bacteria Deliver the Goods (February 28, 2020 12:00pm) https://events.umich.edu/event/72088 72088-17937816@events.umich.edu Event Begins: Friday, February 28, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Lyle Simmons

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Workshop / Seminar Tue, 11 Feb 2020 16:17:26 -0500 2020-02-28T12:00:00-05:00 2020-02-28T13:00:00-05:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB-initials-and-microscope-yellow-square
Biodiversity Lab Chat (February 29, 2020 3:30pm) https://events.umich.edu/event/69903 69903-17758059@events.umich.edu Event Begins: Saturday, February 29, 2020 3:30pm
Location: Biological Sciences Building
Organized By: Museum of Natural History

Join us at the visible labs in the atriums for a discussion about the science happening inside. All ages welcome. Please check the Welcome Desk for times.

Stop by and chat with an educator in front of the Biodiversity Genomics Lab on the second floor, near the giant pterosaur, to learn about how and why scientists process DNA samples from plants and animals around the world.

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Other Mon, 06 Jan 2020 10:31:16 -0500 2020-02-29T15:30:00-05:00 2020-02-29T15:45:00-05:00 Biological Sciences Building Museum of Natural History Other Biological Sciences Building
Cryo-EM Studies of Molecular Motors and Their Associated Filamentous Assemblies- Department of Biological Chemistry Semianr (March 3, 2020 12:00pm) https://events.umich.edu/event/72842 72842-18085912@events.umich.edu Event Begins: Tuesday, March 3, 2020 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Charles Sindelar, Associate Professor of Molecular Biochemistry and Biophysics at Yale School of Medicine will be presenting the Department of Biological Chemistry Seminar on Tuesday March 3rd, 2020 at 12 noon in North Lecture Hall, MS II.

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Workshop / Seminar Thu, 13 Feb 2020 08:27:58 -0500 2020-03-03T12:00:00-05:00 2020-03-03T13:00:00-05:00 Medical Science Unit II Biological Chemistry Workshop / Seminar Sindelar Flyer
NO EEB Tuesday Lunch Seminar today (March 3, 2020 12:00pm) https://events.umich.edu/event/69219 69219-17269223@events.umich.edu Event Begins: Tuesday, March 3, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Tuesday Lunch Seminars return on March 10, 2020.

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Workshop / Seminar Thu, 07 Nov 2019 12:45:24 -0500 2020-03-03T12:00:00-05:00 2020-03-03T13:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Biological Sciences Building background, UM EEB logo and text reading EEB Tuesday Lunch Seminars
Biochemistry and Molecular Biology: How Life Works, Part 1 (March 3, 2020 1:00pm) https://events.umich.edu/event/70473 70473-17600690@events.umich.edu Event Begins: Tuesday, March 3, 2020 1:00pm
Location: Off Campus Location
Organized By: Osher Lifelong Learning Institute (50+)

This course is based on The Great Courses series of lectures by Prof. Kevin Ahern of Oregon State University.* Part 1 will cover the first 23 lectures, concerned with biochemistry. We will view and discuss two half-hour lectures each session. The course will cover topics including amino acids, proteins, ATP and energy transformation, carbs and fats, hormones, neurotransmitters, and many others. This will provide the background for Part 2, planned to be offered in the fall, comprising the final 13 lectures on molecular biology and covering topics such as DNA, RNA and protein building, as well as genetic diseases and cancer. Craig Stephan is a retired industrial physicist who has led many previous OLLI courses including The Science of Climate Change, Cosmology, The Aging Brain, Music and the Brain, and Astrophysics. The course will bring in UM experts from time to time to answer questions. *See www.thegreatcourses.com/courses/biochemistry-and-molecular-biology-how-life-works.html. The Study Group for those 50 and over led by Craig Stephan is held Tuesdays March 3 through May 26.

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Class / Instruction Wed, 18 Dec 2019 10:17:03 -0500 2020-03-03T13:00:00-05:00 2020-03-03T15:00:00-05:00 Off Campus Location Osher Lifelong Learning Institute (50+) Class / Instruction Study Group
Great Lakes Seminar Series (March 3, 2020 1:00pm) https://events.umich.edu/event/73185 73185-18155745@events.umich.edu Event Begins: Tuesday, March 3, 2020 1:00pm
Location: Off Campus Location
Organized By: Cooperative Institute for Great Lakes Research (CIGLR)

Please join us for a Great Lakes Seminar Series presentation!
Date: Tuesday, March 3
Time: 1:00-2:00 pm EDT
Attend In-Person: NOAA Great Lakes Environmental Research Laboratory, Lake Superior Hall* (Directions)
Attend Remotely: https://attendee.gotowebinar.com/register/4302585117583410187

Presenter: Maureen Coleman, University of Chicago
Title: Linking microbial communities and biogeochemistry across the Laurentian Great Lakes

About the presentation: The Laurentian Great Lakes hold 20% of Earth’s surface freshwater and provide essential ecosystem services. Moreover, as an interconnected waterway that spans strong environmental gradients, the Great Lakes represent a unique natural laboratory for understanding how physical, chemical, and biological forces interact to shape microbial communities and biogeochemistry. Here we explore the drivers of microbial diversity and activity across the Great Lakes, using samples collected as part of an ongoing multi-year time series. First we characterized community composition across lakes, depths, seasons, and years. We found that depth and light are strong drivers of community structure in stratified water columns. Across surface waters, we found distinct microbial signatures in each of the Great Lakes, reflecting their biogeochemical variability. To explore metabolic functions, we reconstructed hundreds of microbial genomes and created a microbial tree of life for the Laurentian Great Lakes. We mapped ecological distribution patterns for these genomes and found distinct distributions for taxa and metabolisms across lakes and depths. We focus here on two important groups for ecology and biogeochemistry, the cyanobacteria and nitrifying Bacteria and Archaea. Our work represents the first picture of microbial diversity across the entire Laurentian Great Lakes and is an essential baseline from which to monitor future ecosystem change.

About the speaker: Dr. Coleman is an Assistant Professor in the Department of the Geophysical Sciences at the University of Chicago. She is a microbial ecologist who studies the causes and consequences of microbial diversity in aquatic systems. Currently her lab is busy characterizing microbial communities, genomic diversity, and biogeochemistry across the Laurentian Great Lakes. She is also cultivating new microbial lineages and developing genetic tools to study their biology. She holds an undergraduate degree in biology from Dartmouth College and a Ph.D. in Civil and Environmental Engineering from MIT. She was a postdoc at MIT & Caltech before joining the University of Chicago in 2012.

**Registration is not required to attend in-person, however please note important visitor information below**

Important Visitor Information
All in-person seminar attendees are required to receive a visitor badge from the front desk at the NOAA Great Lakes Environmental Research Laboratory facility. Seminar attendees need to present a valid U.S. photo ID or green card. If you are a Foreign National, advance notification of at least 48 hours is needed so that security guidelines are followed. You will need to present your passport (a copy will NOT work). For questions regarding building access, or assistance in obtaining Foreign National clearance, please call 734-741-2394. Email contact: Scott.Purdy@noaa.gov
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Questions? Contact Mary Ogdahl: ogdahlm@umich.edu
Visit ciglr.seas.umich.edu for more information.

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Presentation Fri, 21 Feb 2020 16:13:30 -0500 2020-03-03T13:00:00-05:00 2020-03-03T14:00:00-05:00 Off Campus Location Cooperative Institute for Great Lakes Research (CIGLR) Presentation Great Lakes Seminar Series Flyer
“Engineered kidney models derived from human induced pluripotent stem cells” (March 3, 2020 4:00pm) https://events.umich.edu/event/73334 73334-18199520@events.umich.edu Event Begins: Tuesday, March 3, 2020 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for Cell Plasticity and Organ Design

The NIH T32 Training Program in Organogenesis is pleased to present a Special Series: "Emerging Topics in Tissue Regeneration and Engineering" featuring seminar guest Samira Musah, Ph.D.

Dr. Musah is an Assistant Professor, Biomedical Engineering, Department of Medicine, Duke University.

The talk is entitled, “Engineered kidney models derived from human induced pluripotent stem cells.”

Trainee Host: Eun-Kyeoung Choi, Ph.D.-The Seo Lab

For additional info: 936-2499 / organogenesis@umich.edu

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Lecture / Discussion Wed, 26 Feb 2020 14:19:07 -0500 2020-03-03T16:00:00-05:00 2020-03-03T17:00:00-05:00 Taubman Biomedical Science Research Building Center for Cell Plasticity and Organ Design Lecture / Discussion Musah Flyer
2020 MASSEY TBI GRAND CHALLENGE KICKOFF (March 5, 2020 8:30am) https://events.umich.edu/event/69927 69927-17489276@events.umich.edu Event Begins: Thursday, March 5, 2020 8:30am
Location: North Campus Research Complex Building 18
Organized By: Michigan Center for Integrative Research in Critical Care (MCIRCC)

The Massey TBI Grand Challenge supports high-impact proposals by funding milestone-driven research over a 12-month timeframe.

This event is made possible thanks to a generous gift from the Joyce and Don Massey Family Foundation. Up to $650,000 is available in 2020 to fund the development of diagnostic, device, therapeutic, or health IT solutions that address the initial ‘golden hours’ of care after severe traumatic brain injury (generally the first 48 hours). Additionally, this year ALL current/past awardees and new awardees will be eligible for the Schwabauer Accelerator Award of $40,000. This will be a separate application.

Note: To be considered for funding, you must attend the Grand Challenge event.

Keynote Speaker:
Odette Harris, MD, MPH, Stanford University School of Medicine

DETAILS & REGISTRATION:
http://bit.ly/2020-TBI-Grand-Challenge

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Other Thu, 23 Jan 2020 12:04:54 -0500 2020-03-05T08:30:00-05:00 2020-03-05T16:00:00-05:00 North Campus Research Complex Building 18 Michigan Center for Integrative Research in Critical Care (MCIRCC) Other 2020 Massey TBI Grand Challenge
How to make a stem cell: Gene regulatory principles learned from vascular fate transitions (March 5, 2020 3:00pm) https://events.umich.edu/event/72083 72083-17937811@events.umich.edu Event Begins: Thursday, March 5, 2020 3:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

We are pleased to welcome Dionna M. Kasper, Ph.D., Post-Doctoral Fellow, Yale University School of Medicine to the Kahn Auditorium in BSRB on Thursday, March 5, 2020.

Hosted by: CDB Recruitment Committee

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Lecture / Discussion Mon, 03 Feb 2020 09:49:59 -0500 2020-03-05T15:00:00-05:00 2020-03-05T16:00:00-05:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion How to make a stem cell: Gene regulatory principles learned from vascular fate transitions
BME 500: Ruobo Zhou (March 5, 2020 4:00pm) https://events.umich.edu/event/73399 73399-18214945@events.umich.edu Event Begins: Thursday, March 5, 2020 4:00pm
Location: Industrial and Operations Engineering Building
Organized By: Biomedical Engineering

Biomolecular interactions are at the root of all biological processes and define the molecular mechanisms of how these processes are accomplished in both physiological and pathological conditions. Recent advances in single molecule detection and super-resolution fluorescence microcopy have uncovered previously unknown properties of biomolecular interactions, including multivalency, transiency, and heterogeneity, and revealed the organizational principles governing the compartmentalization of functional biomolecular interactions in cells and how such compartmentalization and organizations become dysregulated in diseases. In this talk, I will first discuss my postdoctoral work, where I used mass-spectrometry-based analysis and super-resolution imaging to dissect the protein-protein interactions at the plasma membrane of neurons, and discovered that a newly identified membrane-associated periodic skeleton (MPS) structure can function as a signaling platform that coordinates the interactions of signaling proteins at the plasma membrane of neurons. In response to extracellular stimuli, G-protein coupled receptors, cell-adhesion molecules, receptor tyrosine kinases can be recruited to the MPS to form signaling complexes at the plasma membrane, and such recruitment is required for downstream intracellular signaling. This work not only reveals an important, previously unknown function of the newly discovered MPS structure, but also provides novel mechanistic insights into signal transduction in neurons. I will then discuss my graduate work, where I developed a hybrid single molecule technique combining single molecule FRET and optical tweezers, and applied this technique to probe the sub-molecular dynamics of protein-DNA interactions in various biological systems involved in DNA replication, repair and recombination.

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Lecture / Discussion Fri, 28 Feb 2020 11:07:38 -0500 2020-03-05T16:00:00-05:00 2020-03-05T17:00:00-05:00 Industrial and Operations Engineering Building Biomedical Engineering Lecture / Discussion BME Logo
The Mechanics of Animal Survival in an Ever-Changing World (March 10, 2020 11:00am) https://events.umich.edu/event/73477 73477-18243517@events.umich.edu Event Begins: Tuesday, March 10, 2020 11:00am
Location: Lurie Robert H. Engin. Ctr
Organized By: Michigan Robotics

The two greatest human impacts on the Earth are the transformation of natural habitat into industrial landscape and climate change. Our ability to predict how communities of organisms will respond to such disturbances depends on being able to understand how biotic and abiotic interactions influence the survival of individual animals. This talk presents new tools and approaches to quantitatively characterize behavioral variation in biomechanical performance in the real world. This information informs the design of bio-inspired robotic models that emulate current, extinct, and theoretical forms and are used in robot-animal interaction experiments to probe the fundamental biomechanical principles shaping the evolution of animal movement over millions of years. By examining the biomechanics of motions in complex environments, we are better able to predict animal response to ecosystem disturbance. In addition, we are able to design robots capable of successful operation in real-world environments.

Talia Y. Moore is an Assistant Research Scientist in the Robotics Institute at the University of Michigan. She develops tools to enable the quantitative characterization of behavioral variation in animal movement in real-world environments and applies her findings to the design of bio-inspired robots that are used to test evolutionary hypotheses. Dr. Moore is an Associate Editor for International Conference for Biomedical Robotics and Biomechatronics and is a member of IEEE, the Society for Integrative and Comparative Biology, and the Society for the Study of Evolution. She received a PhD in Organismic and Evolutionary Biology from Harvard University in 2016.

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Workshop / Seminar Mon, 02 Mar 2020 15:32:31 -0500 2020-03-10T11:00:00-04:00 2020-03-10T12:00:00-04:00 Lurie Robert H. Engin. Ctr Michigan Robotics Workshop / Seminar jerboa
EEB Tuesday Lunch Seminar: The origin of baleen in whales: inferring soft tissue from bony structures (March 10, 2020 12:00pm) https://events.umich.edu/event/69220 69220-17269224@events.umich.edu Event Begins: Tuesday, March 10, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Please join us for our weekly brown bag lunch seminar.

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Workshop / Seminar Fri, 28 Feb 2020 10:03:10 -0500 2020-03-10T12:00:00-04:00 2020-03-10T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Carlos Peredo working on fossilized bone
Forum on "Climate Change and Health: Readiness and Resilience" (March 10, 2020 12:00pm) https://events.umich.edu/event/72763 72763-18070598@events.umich.edu Event Begins: Tuesday, March 10, 2020 12:00pm
Location: Towsley Center for Cont. Med Ed
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

*Please register by going to http://mleead.umich.edu/Event_Climate_Change_and_Health_2020.php*

Our climate is our planet’s life support system. Climate change influences human health and disease in numerous ways, including impacts from increased extreme weather events, wildfire, decreased air quality, and illnesses transmitted by food, water, and disease carriers such as mosquitoes and ticks. As described in the Lancet Countdown report, some existing health threats will intensify and new health threats will emerge. Not everyone is equally at risk, and children are especially at risk. Preventive and adaptive actions are needed.

The keynote speaker is an emergency medicine physician who co-authored the U.S. portion of the Lancet Countdown report and Health and Care Delivery in the New England Journal of Medicine. A panel of experts will present solutions from a variety of other universities who are reducing their carbon footprint in response to the urgent public health need.

Welcome: Joseph C. Kolars, MD, Senior Associate Dean for Education and Global Initiatives, UM Medical School

Keynote: "Climate Action: Children’s Health Drives Need for Urgent Action" Renee N. Salas, MD, MPH, MS, Clinical Instructor of Emergency Medicine, Harvard Medical School and emergency medicine physician, Massachusetts General Hospital

Schedule
11:00-11:45 am | Registration outside of Dow Auditorium, Towsley Center for Continuing Medical Education, Michigan Medicine
11:00-11:45 am | Lunch in Towsley Center Dining Room for registered guests
12:00-1:30 pm | Program in Dow Auditorium, Towsley Center (also will be live streamed)
1:30-2:00 pm | Reception in Towsley Center Dining Room

*Please register by going to http://mleead.umich.edu/Event_Climate_Change_and_Health_2020.php*

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Conference / Symposium Fri, 21 Feb 2020 13:52:24 -0500 2020-03-10T12:00:00-04:00 2020-03-10T13:30:00-04:00 Towsley Center for Cont. Med Ed Michigan Lifestage Environmental Exposures and Disease Center Conference / Symposium Climate Change and Health: Readiness and Resilience
Development of genetically engineered mouse models of brainstem glioma: therapeutic efficacy of an immune mediated gene therapy strategy (March 10, 2020 2:00pm) https://events.umich.edu/event/72701 72701-18061828@events.umich.edu Event Begins: Tuesday, March 10, 2020 2:00pm
Location: Medical Science Unit II
Organized By: Cell & Developmental Biology

Dissertation Seminar:
We are pleased to welcome Flor Mendez, Ph.D. Student at University of Michigan to 2710 Furstenberg, Med Sci II on March 10th, 2020 at 2:00 pm to present her dissertation seminar.

Hosted by the Dissertation Committee:
Professor Maria Castro, Mentor
Professor Roman Giger, Chair
Associate Professor Maria Figueroa
Associate Professor Marina Pasca Di Magliano

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Lecture / Discussion Mon, 10 Feb 2020 15:06:45 -0500 2020-03-10T14:00:00-04:00 2020-03-10T15:00:00-04:00 Medical Science Unit II Cell & Developmental Biology Lecture / Discussion Development of genetically engineered mouse models of brainstem glioma: therapeutic efficacy of an immune mediated gene therapy strategy - Flor Mendez
MCDB Dissertation Defense: "Molecular Mechanisms of Golgi Structure Alterations during Stress” (March 10, 2020 2:00pm) https://events.umich.edu/event/72769 72769-18070599@events.umich.edu Event Begins: Tuesday, March 10, 2020 2:00pm
Location: Rackham Graduate School (Horace H.)
Organized By: Department of Molecular, Cellular, and Developmental Biology

Mentor: Y. Wang

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Workshop / Seminar Mon, 09 Mar 2020 15:49:26 -0400 2020-03-10T14:00:00-04:00 2020-03-10T16:00:00-04:00 Rackham Graduate School (Horace H.) Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials & microscope drawing in yellow on a blue square
“Epigenetic pathways as targets in human disease” (March 10, 2020 4:00pm) https://events.umich.edu/event/73335 73335-18199521@events.umich.edu Event Begins: Tuesday, March 10, 2020 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for Cell Plasticity and Organ Design

Center for Organogenesis along with the Human Genetics Depatment is pleased to present a seminar talk by Dr. Shelley Berger.

Dr. Berger is Daniel S. Och Professor of Cell & Developmental Biology at University of Pennsylvania School of Medicine.

The talk is entitled, “Epigenetic pathways as targets in human disease.”

Faculty Host: Sue Hammoud, Ph.D.

For additional info: 936-2499 / organogenesis@umich.edu

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Lecture / Discussion Wed, 26 Feb 2020 14:29:36 -0500 2020-03-10T16:00:00-04:00 2020-03-10T17:00:00-04:00 Taubman Biomedical Science Research Building Center for Cell Plasticity and Organ Design Lecture / Discussion Berger Flyer
DCMB Weekly Seminar (March 11, 2020 4:00pm) https://events.umich.edu/event/73002 73002-18123077@events.umich.edu Event Begins: Wednesday, March 11, 2020 4:00pm
Location:
Organized By: DCMB Seminar Series

Abstract:

In this talk, some major challenges are reviewed of using Artificial Intelligence (AI) to address the needs of medicine and healthcare. These challenges include technical issues such as data-related and/or algorithmic challenges that the use of AI for medicine would present. The speaker then presents some potential solutions in form of novel algorithmic approaches that may at least partially address some of these challenges.

BlueJeans livestream: https://primetime.bluejeans.com/a2m/live-event/rbuvycdc

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Lecture / Discussion Wed, 11 Mar 2020 08:49:28 -0400 2020-03-11T16:00:00-04:00 2020-03-11T17:00:00-04:00 DCMB Seminar Series Lecture / Discussion
CANCELLED: Our Constitution and Our Children in the Era of Climate Crisis: Juliana v. United States (March 12, 2020 12:00pm) https://events.umich.edu/event/73028 73028-18129604@events.umich.edu Event Begins: Thursday, March 12, 2020 12:00pm
Location: Jeffries Hall
Organized By: Michigan Law Environmental and Energy Law Program

This lecture has been CANCELLED.

Please join us for the latest installment of the Environmental Law & Policy Program Lecture Series. Julia Olson, Executive Director and Chief Legal Counsel of Our Children's Trust, will speak about Juliana v. United States.

This event is free and open to the public.

Julia Olson graduated from the University of California, Hastings College of the Law, with a J.D. in 1997. For the first part of her 22-year career, Julia represented grassroots conservation groups working to protect the environment, organic agriculture, and human health. After becoming a mother, and realizing the greatest threat to her children and children everywhere was climate change, she focused her work on representing young people and elevating their voices on the issue that will most determine the quality of their lives and the well-being of all future generations. Julia founded Our Children’s Trust in 2010 to lead this strategic legal campaign on behalf of the world’s youth against governments everywhere. Julia leads Juliana v. the United States, the constitutional climate change case brought by 21 youth against the U.S. government for violating their Fifth Amendment rights to life, liberty, property, and public trust resources. Julia and OCT are recipients of the Rose-Walters Prize for Global Environmental Activism. She received the Kerry Rydberg Award for Environmental Activism in 2017 and is a member of Rachel's Network Circle of Advisors. To rejuvenate, Julia loves being high up in the mountains with her family and her dog or playing tunes on her ukulele with friends.

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Lecture / Discussion Thu, 12 Mar 2020 09:11:27 -0400 2020-03-12T12:00:00-04:00 2020-03-12T13:00:00-04:00 Jeffries Hall Michigan Law Environmental and Energy Law Program Lecture / Discussion
BME 500: Rebecca Wachs (March 12, 2020 4:00pm) https://events.umich.edu/event/70068 70068-17505695@events.umich.edu Event Begins: Thursday, March 12, 2020 4:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

The majority of the population will experience low back pain in their lifetime. Degeneration of the intervertebral disc is highly correlated with low back pain, however, not all disc degeneration is painful. One of the most common forms of low back pain is disc-associated low back pain in which pain originates from intervertebral disc. In disc-associated low back pain, nerve fibers penetrate the previously aneural disc, where they are then thought to be stimulated by the harsh catabolic environment. Repetitive stimulation of these nerve fibers can cause sensitization and chronic pain. The overarching goal of our work is to engineer biomaterials that target these two key areas of disc-associated low back pain: nerve growth and stimulation. Current clinical treatments for chronic low back pain have limited efficacy or are highly invasive. The majority of research to date focuses on regenerating a young healthy disc. We believe our approach to target nerve growth and stimulation independent of disc regeneration has the potential shift the paradigm in the treatment of low back pain.

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Workshop / Seminar Tue, 10 Mar 2020 11:43:59 -0400 2020-03-12T16:00:00-04:00 2020-03-12T17:00:00-04:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar BME Event
Canceled: EEB Thursday Seminar: The plant mating system and the evolution of resistance (March 12, 2020 4:00pm) https://events.umich.edu/event/69045 69045-17220026@events.umich.edu Event Begins: Thursday, March 12, 2020 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

The mating system, or who mates with whom, and how often, is a critical trait that influences the distribution of genetic variation among populations as well as fitness and the ability of populations to respond to selection. Although we know that the plant mating system is strongly influenced by environmental factors, we do not understand if and how the mating system may be shaped by anthropogenic forces. In this talk, I give a brief overview of the ongoing ecological genetics/genomics projects within the lab and focus on our attempts to understand how the mating system may evolve given regimes of strong human-mediated selection.

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Workshop / Seminar Wed, 11 Mar 2020 11:08:19 -0400 2020-03-12T16:00:00-04:00 2020-03-12T17:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Baucom - Plant mating systems photo
[FREE- NOW ONLINE!]Great Lakes Theme Semester Presents: #LakeEffects Film Series (March 12, 2020 6:30pm) https://events.umich.edu/event/73624 73624-18272030@events.umich.edu Event Begins: Thursday, March 12, 2020 6:30pm
Location:
Organized By: Great Lakes Theme Semester

Hosted by Michigan Sea Grant and co-sponsored by Great Lakes Now, this completely free series will have a different theme each night: Journeys, Shipwrecks, Invaders, Hazards, Detroit Public TV Night.

Join us every Thursday for the next five weeks now on Zoom! Join us virtually for an hour and a half screening followed by a brief Q&A with filmmakers, participants, and local experts. We hope to see you there!
https://zoom.us/j/380790681

March 12: Journeys
The Big Five Dive
Crossing Lake Huron

March 19: Shipwrecks
Project Shiphunt
November Requiem

March 26: Invaders
Making Waves

April 2: Hazards
Great Lakes, Bad Lines
The Forever Chemicals

April 9: Detroit Public TV Night
Selections from Great Lakes Now

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Livestream / Virtual Mon, 01 Mar 2021 15:33:59 -0500 2020-03-12T18:30:00-04:00 2020-03-12T21:00:00-04:00 Great Lakes Theme Semester Livestream / Virtual U-M LSA Great Lakes Theme Semester, Lake Effects, with topographical map of Michigan
Annual Symposium in Biophysics (March 13, 2020 8:00am) https://events.umich.edu/event/69839 69839-17472589@events.umich.edu Event Begins: Friday, March 13, 2020 8:00am
Location: Michigan Union
Organized By: LSA Biophysics

TBD

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Conference / Symposium Mon, 02 Dec 2019 08:43:25 -0500 2020-03-13T08:00:00-04:00 2020-03-13T17:00:00-04:00 Michigan Union LSA Biophysics Conference / Symposium Michigan Union
Speciation-Based Species Delimitation Workshop (March 13, 2020 9:00am) https://events.umich.edu/event/73661 73661-18278620@events.umich.edu Event Begins: Friday, March 13, 2020 9:00am
Location: East Hall
Organized By: Ecology and Evolutionary Biology

The resolution in genomic data makes it possible to not only detect divergent lineages, but also local population structure within them. Yet, these conflated boundaries have received little attention from those developing genetic-based species delimitation methods, potentially leading to mass over-splitting as genomic data become more widely employed. These challenges have profound implications for not only understanding the generation and dynamics of biodiversity, but also for conserving this diversity.

In this workshop, we will cover the foundations upon which genetic-based inference of species boundaries are built. In particular, we will review the history that lead to a reliance on the multispecies coalescent (MSC) as the primary model for species delimitation. Despite the appeal of genome-based species discovery, we will explain how misidentification of population structure as putative species is an emerging key issue for applications of the MSC for species delimitation, as well as the implications of divergence of gene flow for identifying species boundaries.

Read more at the website linked on this page

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Workshop / Seminar Fri, 06 Mar 2020 14:25:13 -0500 2020-03-13T09:00:00-04:00 2020-03-13T12:00:00-04:00 East Hall Ecology and Evolutionary Biology Workshop / Seminar Illustrated bar graph showing lizards number of species estimate versus actual
CANCELED: Mechanisms Linking Cell Mechanics and Metabolism (March 13, 2020 12:00pm) https://events.umich.edu/event/72757 72757-18070590@events.umich.edu Event Begins: Friday, March 13, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Ann Miller

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Workshop / Seminar Tue, 10 Mar 2020 11:32:19 -0400 2020-03-13T12:00:00-04:00 2020-03-13T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar microscope drawing, MCDB initials in yellow on blue background
Speciation-Based Species Delimitation Workshop (March 13, 2020 2:00pm) https://events.umich.edu/event/73661 73661-18278622@events.umich.edu Event Begins: Friday, March 13, 2020 2:00pm
Location: Undergraduate Science Building
Organized By: Ecology and Evolutionary Biology

The resolution in genomic data makes it possible to not only detect divergent lineages, but also local population structure within them. Yet, these conflated boundaries have received little attention from those developing genetic-based species delimitation methods, potentially leading to mass over-splitting as genomic data become more widely employed. These challenges have profound implications for not only understanding the generation and dynamics of biodiversity, but also for conserving this diversity.

In this workshop, we will cover the foundations upon which genetic-based inference of species boundaries are built. In particular, we will review the history that lead to a reliance on the multispecies coalescent (MSC) as the primary model for species delimitation. Despite the appeal of genome-based species discovery, we will explain how misidentification of population structure as putative species is an emerging key issue for applications of the MSC for species delimitation, as well as the implications of divergence of gene flow for identifying species boundaries.

Read more at the website linked on this page

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Workshop / Seminar Fri, 06 Mar 2020 14:25:13 -0500 2020-03-13T14:00:00-04:00 2020-03-13T17:00:00-04:00 Undergraduate Science Building Ecology and Evolutionary Biology Workshop / Seminar Illustrated bar graph showing lizards number of species estimate versus actual
POSTPONED until fall 2020: EEB Early Career Scientists Symposium | Natural History Collections: Drivers of Innovation (March 14, 2020 8:00am) https://events.umich.edu/event/70505 70505-17602796@events.umich.edu Event Begins: Saturday, March 14, 2020 8:00am
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Watch for updates later this year.

The Department of Ecology and Evolutionary Biology at the University of Michigan is pleased to present Natural History Collections: Drivers of Innovation, an exciting symposium about innovative and unconventional uses of biological collections across scientific disciplines. The symposium events will take place from the 13-15 March 2020, on the campus of the University of Michigan in Ann Arbor.

When biologists think of natural history collections, most tend to think of taxonomy and systematics, yet many are unaware of the uses of biological collections beyond those traditional fields. These studies span the breadth of the tree of life and address broad subjects that span comparative genomics to bioengineering and climate change to historical pathogen dynamics, among many, many more. As stewards of one of the largest university-based biological collections in the world, we are in an extraordinary position to leverage our holdings of biological material from the last century or more. We envision this symposium as a way to showcase the often-unrealized opportunities and non-traditional avenues of research that our collections make possible to the entire scientific community, and emphasize some of the interdisciplinary ways in which our collections are being or could be used. We hope to foster a broader understanding and expanded use of an incomparable resource that the University of Michigan has cultivated for the past two hundred years.

The symposium will feature both established and novel uses of natural history collections across a wide range of taxonomic groups, systems, and time. Our goal is to create a program with contributions from all corners of ecology and evolutionary biology. The program will include two keynote talks by senior speakers and additional talks by early-career speakers.

Thank you!

ECSS 2020 Committee
Jenna Crowe-Riddell
Sonal Gupta
Hernán Lopez-Fernandez, chair
Benjamin Nicholas
Teresa Pegan
Brad Ruhfel
Cody Thompson
Taylor West

Administrative Support
Event coordination: Linda Garcia & Molly Hunter
Event promotion: Gail Kuhnlein
Graphic design/art: John Megahan
Photography: Dale Austin

Image credits:
Painted meadow grasshopper, western rattlesnake, burrowing owl: Eric LoPresti. Moon snail, plant, rabbit skull: John Megahan. Mushrooms: Tim James. Background cabinet: Linda Garcia. Design: John Megahan.

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Conference / Symposium Tue, 10 Mar 2020 16:24:06 -0400 2020-03-14T08:00:00-04:00 2020-03-14T17:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Conference / Symposium Background of collections drawers with boxes on top containing the following: moon snail, painted meadow grasshopper, plant, mushrooms, western rattlesnake, burrowing owl, rabbit skull
Project Management Certification (March 15, 2020 12:00pm) https://events.umich.edu/event/73563 73563-18261071@events.umich.edu Event Begins: Sunday, March 15, 2020 12:00pm
Location: Ross School of Business
Organized By: Tauber Institute for Global Operations

Once again, the Tauber Institute, in conjunction with the International Project Management Association (IPMA), is sponsoring a Project Management certification class and exam for graduate business and engineering students and staff.

In order to participate, you will need to reflect upon a project management experience (for example a work project, an engineering design experience/senior capstone, Ross' MAP project, Tauber team project, etc). If you cannot make it to the classes (due to project travel, MAP, or other another class), the sessions will be recorded. Homework (mastery verification) will be required after each session.

The cost to an individual to take the exam is normally $595, however, Tauber is offering the exam at a substantial discount to non-Tauber students: $500 and to Tauber students: $150. Certification is valid for 5 years. Three certification classes will be taught by Professor Eric Svaan on the following dates:

Sunday, March 15 (noon - 4:30 pm, Ross R-0420)
Sunday, March 29 (noon - 4:30 pm, Ross R-0420)
Sunday, April 5 (noon - 4:30 pm, Ross R-0420)

The certification exam, administered by IPMA-USA is scheduled for April 26, 2020 (11:00 am) at the Ross School of Business, R-0320. Successfully passing the exam will yield IPMA's Level D certification (Certified Project Management Associate).

Over the last two years, all students who have taken the exam have passed!

Project Management is a powerful skillset to have in your toolbox as you look for full-time employment!

REGISTRATION: Please register through iMpact by clicking here:
http://myumi.ch/dO5Nl

NOTE: The $500 (for non-Tauber students) or $150 fee (for Tauber students) is non-refundable.

HOSTED BY: Tauber Institute for Global Operations. For questions about this event, please contact tauberinstitute@umich.edu or visit tauber.umich.edu.

What is IPMA Level D® (Certified Project Management Associate)? The IPMA Level D is an internationally recognized entry-level qualification in the area of project management. This designation, which demonstrates the individual's ability to understand the basics of project management, is similar to the exam-oriented, knowledge-based certifications of other major Project Management associations. For many, Level D® is the first step towards a professional project or program manager role. It is the first step in a sequence (C, B, and A) to be earned by demonstration of success in larger PM responsibility sets.

For more information,
Visit tauber.umich.edu or call 734-647-1333
Connect via email to Diana Crossley dianak@umich.edu

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Class / Instruction Thu, 05 Mar 2020 10:07:18 -0500 2020-03-15T12:00:00-04:00 2020-03-15T16:30:00-04:00 Ross School of Business Tauber Institute for Global Operations Class / Instruction Photo of certificate
CANCELED: Organization of cellular fat store . . . (March 17, 2020 12:00pm) https://events.umich.edu/event/72758 72758-18070591@events.umich.edu Event Begins: Tuesday, March 17, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

This seminar has been cancelled.

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Workshop / Seminar Tue, 10 Mar 2020 10:50:42 -0400 2020-03-17T12:00:00-04:00 2020-03-17T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials and yellow microscope drawing on a blue square
Canceled: EEB Tuesday Lunch Seminar: Specialization through timing: How temporal resource overlap and interacting phenologies drive specialization in pollinators (March 17, 2020 12:00pm) https://events.umich.edu/event/69221 69221-17269225@events.umich.edu Event Begins: Tuesday, March 17, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Please join us for our weekly brown bag lunch seminar.

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Workshop / Seminar Wed, 11 Mar 2020 13:21:33 -0400 2020-03-17T12:00:00-04:00 2020-03-17T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar chart showing 4 pollinators on one side with lines connecting and overlapping to 4 different flowers on the other side
CANCELED: "Human Nature" panel discussion (March 18, 2020 7:30pm) https://events.umich.edu/event/72924 72924-18096982@events.umich.edu Event Begins: Wednesday, March 18, 2020 7:30pm
Location: Off Campus Location
Organized By: Precision Health

THE PANEL DISCUSSION HAS BEEN CANCELED.

For information about the film, please see Michigan Theater's website:
https://www.michtheater.org/show/human-nature/

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Film Screening Thu, 12 Mar 2020 09:49:25 -0400 2020-03-18T19:30:00-04:00 2020-03-18T22:00:00-04:00 Off Campus Location Precision Health Film Screening Human Nature
Canceled: EEB Thursday Seminar (March 19, 2020 4:00pm) https://events.umich.edu/event/69046 69046-17220027@events.umich.edu Event Begins: Thursday, March 19, 2020 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

TDB

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Workshop / Seminar Wed, 11 Mar 2020 13:22:38 -0400 2020-03-19T16:00:00-04:00 2020-03-19T17:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Biological Sciences Building
[FREE- NOW ONLINE!]Great Lakes Theme Semester Presents: #LakeEffects Film Series (March 19, 2020 6:30pm) https://events.umich.edu/event/73624 73624-18272031@events.umich.edu Event Begins: Thursday, March 19, 2020 6:30pm
Location: Off Campus Location
Organized By: Great Lakes Theme Semester

Hosted by Michigan Sea Grant and co-sponsored by Great Lakes Now, this completely free series will have a different theme each night: Journeys, Shipwrecks, Invaders, Hazards, Detroit Public TV Night.

Join us every Thursday for the next five weeks now on Zoom! Join us virtually for an hour and a half screening followed by a brief Q&A with filmmakers, participants, and local experts. We hope to see you there!
https://zoom.us/j/380790681

March 12: Journeys
The Big Five Dive
Crossing Lake Huron

March 19: Shipwrecks
Project Shiphunt
November Requiem

March 26: Invaders
Making Waves

April 2: Hazards
Great Lakes, Bad Lines
The Forever Chemicals

April 9: Detroit Public TV Night
Selections from Great Lakes Now

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Livestream / Virtual Mon, 01 Mar 2021 15:33:59 -0500 2020-03-19T18:30:00-04:00 2020-03-19T21:00:00-04:00 Off Campus Location Great Lakes Theme Semester Livestream / Virtual U-M LSA Great Lakes Theme Semester, Lake Effects, with topographical map of Michigan
CANCELED! From Laboratory to Population: Molecular Epidemiology in Action (March 20, 2020 9:00am) https://events.umich.edu/event/71052 71052-17768679@events.umich.edu Event Begins: Friday, March 20, 2020 9:00am
Location: Rackham Graduate School (Horace H.)
Organized By: MAC-EPID

"Antibiotic use during pregnancy: Too much of a good thing?"
Lixin Zhang, PhD (Assistant Professor, Epidemiology & Biostatistics and Microbiology & Molecular Genetics, Michigan State University)

"Group B streptococcal epidemiology and pathogenesis: A tribute to Carl Marrs’ mentorship"
Shannon Manning, PhD (MSU Foundation Associate Professor of Microbiology and Molecular Genetics, Michigan State University)

"Integrating Operational Research to Combat Epidemics: Investigating Ebola Infection among Health Workers in Kenema, Sierra Leone, 2014"
Mikiko Senga, PhD (Disease Outbreak Team Lead, Health Emergencies Programme, World Health Organization, Yemen)

Epidemiology Alumni Reception directly following talks.

Please register for this free symposium since lunch will be provided. Thank you!

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Conference / Symposium Wed, 11 Mar 2020 16:26:18 -0400 2020-03-20T09:00:00-04:00 2020-03-20T16:00:00-04:00 Rackham Graduate School (Horace H.) MAC-EPID Conference / Symposium CANCELED Flyer
Canceled: Shaping the cell from the outside in (March 20, 2020 12:00pm) https://events.umich.edu/event/72760 72760-18070592@events.umich.edu Event Begins: Friday, March 20, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Anthony Vecchiarelli

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Workshop / Seminar Tue, 10 Mar 2020 14:55:11 -0400 2020-03-20T12:00:00-04:00 2020-03-20T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials & microscope drawing in yellow on a blue square
CANCELED: EEB Museums Friday Seminar - Negotiating Academic/Tribal Research Agendas Involving Plants, Properties, and a Sustainable Future: UM as an emerging case of national significance (March 20, 2020 2:00pm) https://events.umich.edu/event/73639 73639-18276407@events.umich.edu Event Begins: Friday, March 20, 2020 2:00pm
Location: Research Museums Center
Organized By: Herbarium

The diverse ‘museum and museum-like’ collections of Tier 1 Research Universities, as those at RMC and the Matthaei-Nichols, have pivotal roles in the emerging protocols of Tribally-engaged research outside the biomedical sciences. At UM, in addition to each unit’s intellectual and disciplinary agendas, our Tribal engagements profoundly influence other core functions of the university: from undergraduate recruitment to donor and foundation relationships. Based on more than 15 years of relationship-building, Michener has developed UM Matthaei-Nichols as a key partner in broadening and refocusing plant- and environmental justice-centered research relationships with Michigan’s Tribal partners. The ways forward include deepening engagement with the research divisions at RMC. By mutual agreement with Tribal partners, little of this work has been discussed in public venues until recently. Today’s talk will focus on specific Tribally-engaged research activities at the Matthaei-Nichols, their immediate objectives, and the anticipated impacts for all partners.

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Lecture / Discussion Wed, 11 Mar 2020 13:59:26 -0400 2020-03-20T14:00:00-04:00 2020-03-20T15:00:00-04:00 Research Museums Center Herbarium Lecture / Discussion 2:00 PM - Friday March 20, RMC Rm 1006
Canceled: Tuesday Lunch Seminar (March 24, 2020 12:00pm) https://events.umich.edu/event/69222 69222-17269226@events.umich.edu Event Begins: Tuesday, March 24, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Please join us for our weekly brown bag lunch seminar.

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Workshop / Seminar Wed, 11 Mar 2020 13:25:53 -0400 2020-03-24T12:00:00-04:00 2020-03-24T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Biological Sciences Building background, UM EEB logo and text reading EEB Tuesday Lunch Seminars
LHS Collaboratory Webinar "Mobilizing Computable Biomedical Knowledge at Michigan Medicine" (March 24, 2020 12:00pm) https://events.umich.edu/event/72652 72652-18035599@events.umich.edu Event Begins: Tuesday, March 24, 2020 12:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Presentation 1:
"Electronic Health Record (EHR)-Integration for Learning Health Systems"

Michael Lanham, MD
Associate Chief Medical Information Officer
Clinical Assistant Professor of Learning Health Sciences
Assistant Professor of Obstetrics & Gynecology; Fertility and Reproductive Health
University of Michigan

Presentation 2:
“Machine Learning Infrastructure in a Learning Health System”

Karandeep Singh, MD, MMSc
Assistant Professor of Learning Health Sciences
Assistant Professor of Medicine
University of Michigan


Please register in advance, *dlhs-umi.ch/lhs-collaboratory. *
Email: *LHScollaboratory-info@umich.edu*

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Lecture / Discussion Wed, 18 Mar 2020 10:04:19 -0400 2020-03-24T12:00:00-04:00 2020-03-24T13:30:00-04:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion LHS Collaboratory
(CANCELLED)“Exploring mechanisms of cell number compensation during brain development and cancer” (March 24, 2020 4:00pm) https://events.umich.edu/event/73360 73360-18328747@events.umich.edu Event Begins: Tuesday, March 24, 2020 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for Cell Plasticity and Organ Design

Center for Organogenesis along with the Human Genetics Depatment is pleased to present a seminar talk by Dr. Alexandra Joyner.

Dr. Joyner is Courtney Steel Chair in Pediatric Cancer Research Developmental Biology Program at Sloan Kettering Institute.

The talk is entitled, “Exploring mechanisms of cell number compensation during brain development and cancer.”

Faculty Host: Ben Allen, Ph.D.

For additional info: 936-2499 / organogenesis@umich.edu

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Lecture / Discussion Mon, 09 Mar 2020 10:01:09 -0400 2020-03-24T16:00:00-04:00 2020-03-24T17:00:00-04:00 Taubman Biomedical Science Research Building Center for Cell Plasticity and Organ Design Lecture / Discussion Joyner Seminar Flyer
Zhen Xu, PhD: Histotripsy Webinar (March 25, 2020 10:00am) https://events.umich.edu/event/73931 73931-18426654@events.umich.edu Event Begins: Wednesday, March 25, 2020 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This will be held online. Click the link below to register.

https://fusfoundation.zoom.us/webinar/register/WN_Hj_R2DMOT8SlOAp0WRLV3A

Oftentimes when we think of focused ultrasound, we imagine using it to heat and kill tissue. Unlike thermal ablation, histotripsy uses focused ultrasound to mechanically disrupt the target tissue without heating. Histotripsy turns the tissue into liquid-appearing acellular debris – which is absorbed by the body over one to two months – resulting in effective tissue removal.

Histotripsy has been shown to stimulate a powerful immune response in cancer treatment studies. In the treatment of neurological diseases, transcranial histotripsy can produce well-confined focal treatment in a wide range of locations and volumes in the brain, offering the potential to increase the treatment envelope while decreasing treatment time.

Please register to join us at 10:00 AM Eastern on Wednesday, March 25, when Zhen Xu, PhD, will discuss the basic mechanism, instrumentation, bioeffects, and applications of histotripsy. She will also cover the latest preclinical and clinical trial results of developing histotripsy for the treatment of cancer and neurological diseases.

About the Speaker

Zhen Xu, PhD, is a tenured Associate Professor in the Department of Biomedical Engineering at the University of Michigan and a primary inventor and pioneer in histotripsy.

She has received many notable awards, including:
IEEE Ultrasonics, Ferroelectrics, and Frequency Control Society Outstanding Paper Award (2006)
American Heart Association Outstanding Research in Pediatric Cardiology (2010)
National Institutes of Health (NIH) New Investigator Award at the First National Institute of Biomedical Imaging and Bioengineering (NIBIB) Edward C. Nagy New Investigator Symposium (2011)
The Federic Lizzi Early Career Award from The International Society of Therapeutic Ultrasound (ISTU) (2015)
Fellow of the American Institute of Medical and Biological Engineering (2019)
Dr. Xu is currently an associate editor for three notable journals: IEEE Transactions on Ultrasound, Ferroelectrics, and Frequency Control (UFFC); Frontiers in Bioengineering; and BME Frontiers. She is an elected board member of ISTU, a charter member of the US NIH study section, and a principal investigator of grants funded by the Focused Ultrasound Foundation, NIH, American Cancer Association, Office of Naval Research, The Hartwell Foundation, and The Coulter Foundation.

She received her PhD from the University of Michigan in 2005.

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Livestream / Virtual Mon, 23 Mar 2020 14:42:17 -0400 2020-03-25T10:00:00-04:00 2020-03-25T11:00:00-04:00 Off Campus Location Biomedical Engineering Livestream / Virtual BME Logo
Ph.D. Defense: Tyler Gerhardson (March 26, 2020 10:00am) https://events.umich.edu/event/73025 73025-18129601@events.umich.edu Event Begins: Thursday, March 26, 2020 10:00am
Location: Lurie Robert H. Engin. Ctr
Organized By: Biomedical Engineering

NOTICE: Will be held via BlueJeans.

Link: https://umich.bluejeans.com/924142541

Brain pathologies including stroke and cancer are a major cause of death and disability. Intracerebral hemorrhage (ICH) accounts for roughly 12% of all strokes in the US with approximately 200,000 new cases per year. ICH is characterized by the rupture of vessels resulting in bleeding and clotting inside the brain. The presence of the clot causes immediate damage to surrounding brain tissue via mass effect with delayed toxic effects developing in the days following the hemorrhage. This leads ICH patients to high mortality with a 40% chance of death within 30 days of diagnosis and motivates the need to quickly evacuate the clot from the brain. Craniotomy surgery and other minimally invasive methods using thrombolytic drugs are common procedures to remove the clot but are limited by factors such as morbidity and high susceptibility to rebleeding, which ultimately result in poor clinical outcomes.

Histotripsy is a non-thermal ultrasound ablation technique that uses short duration, high amplitude rarefactional pulses (>26 MPa) delivered via an extracorporeal transducer to generate targeted cavitation using the intrinsic gas nuclei existing in the target tissue. The rapid and energetic bubble expansion and collapse of cavitation create high stress and strain in tissue at the focus that fractionate it into an acellular homogenate. This dissertation presents the role of histotripsy as a novel ultrasound technology with potential to address the need for an effective transcranial therapy for ICH and other brain pathologies.

The first part of this work investigates the effects of ultrasound frequency and focal spacing on transcranial clot liquefaction using histotripsy. Histotripsy pulses were delivered using two 256-element hemispherical transducers of different frequency (250 and 500 kHz) with 30-cm aperture diameters. Liquefied clot was drained via catheter and syringe in the range of 6-59 mL in 0.9-42.4 min. The fastest rate was 16.6 mL/min. The best parameter combination was λ spacing at 500 kHz, which produced large liquefaction through 3 skullcaps (~30 mL) with fast rates (~2 mL/min). The temperature-rise through the 3 skullcaps remained below 4°C.

The second part addresses initial safety concerns for histotripsy ICH treatment through investigation in a porcine ICH model. 1.75-mL clots were formed in the frontal lobe of the brain. The centers of the clots were liquefied with histotripsy 48 h after formation, and the content was either evacuated or left within the brain. A control group was left untreated. Histotripsy was able to liquefy the core of clots without direct damage to the perihematomal brain tissue. An average volume of 0.9 ± 0.5 mL (~50%) was drained after histotripsy treatment. All groups showed mild ischemia and gliosis in the perihematomal region; however, there were no deaths or signs of neurological dysfunction in any groups.

The third part presents the development of a novel catheter hydrophone method for transcranial phase aberration correction and drainage of the clot liquefied with histotripsy. A prototype hydrophone was fabricated to fit within a ventriculostomy catheter. Improvements in focal pressure of up to 60% were achieved at the geometric focus and 27%-62% across a range of electronic steering locations. The sagittal and axial -6-dB beam widths decreased from 4.6 to 2.2 mm in the sagittal direction and 8 to 4.4 mm in the axial direction, compared to 1.5 and 3 mm in the absence of aberration. The cores of clots liquefied with histotripsy were readily drained via the catheter.

The fourth part focuses on the development of a preclinical system for translation to human cadaver ICH models. A 360-element, 700 kHz hemispherical array with a 30 cm aperture was designed and integrated with an optical tracker surgical navigation system. Calibrated simulations of the transducer suggest a therapeutic range between 48 – 105 mL through the human skull with the ability to apply therapy pulses at pulse-repetition-frequencies up to 200 Hz. The navigation system allows real-time targeting and placement of the catheter hydrophone via a pre-operative CT or MRI.

The fifth and final part of this work extends transcranial histotripsy therapy beyond ICH to the treatment of glioblastoma. This section presents results from an initial investigation into cancer immunomodulation using histotripsy in a mouse glioblastoma model. The results suggest histotripsy has some immunomodulatory capacity as evidenced by a 2-fold reduction in myeloid derived suppressor cells and large increases in interferon-γ concentrations (3500 pg/mL) within the brain tumors of mice treated with histotripsy.

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Lecture / Discussion Mon, 16 Mar 2020 13:26:52 -0400 2020-03-26T10:00:00-04:00 2020-03-26T11:00:00-04:00 Lurie Robert H. Engin. Ctr Biomedical Engineering Lecture / Discussion BME Logo
Canceled: EEB Thursday Seminar (March 26, 2020 4:00pm) https://events.umich.edu/event/69047 69047-17220028@events.umich.edu Event Begins: Thursday, March 26, 2020 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

TBD

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Workshop / Seminar Wed, 11 Mar 2020 13:27:46 -0400 2020-03-26T16:00:00-04:00 2020-03-26T17:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Biological Sciences Building
[FREE- NOW ONLINE!]Great Lakes Theme Semester Presents: #LakeEffects Film Series (March 26, 2020 6:30pm) https://events.umich.edu/event/73624 73624-18272032@events.umich.edu Event Begins: Thursday, March 26, 2020 6:30pm
Location: Off Campus Location
Organized By: Great Lakes Theme Semester

Hosted by Michigan Sea Grant and co-sponsored by Great Lakes Now, this completely free series will have a different theme each night: Journeys, Shipwrecks, Invaders, Hazards, Detroit Public TV Night.

Join us every Thursday for the next five weeks now on Zoom! Join us virtually for an hour and a half screening followed by a brief Q&A with filmmakers, participants, and local experts. We hope to see you there!
https://zoom.us/j/380790681

March 12: Journeys
The Big Five Dive
Crossing Lake Huron

March 19: Shipwrecks
Project Shiphunt
November Requiem

March 26: Invaders
Making Waves

April 2: Hazards
Great Lakes, Bad Lines
The Forever Chemicals

April 9: Detroit Public TV Night
Selections from Great Lakes Now

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Livestream / Virtual Mon, 01 Mar 2021 15:33:59 -0500 2020-03-26T18:30:00-04:00 2020-03-26T21:00:00-04:00 Off Campus Location Great Lakes Theme Semester Livestream / Virtual U-M LSA Great Lakes Theme Semester, Lake Effects, with topographical map of Michigan
CANCELED Coatopathies: Genetic Disorders of Protein Coat (March 27, 2020 12:00pm) https://events.umich.edu/event/72762 72762-18070593@events.umich.edu Event Begins: Friday, March 27, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Ming Li

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Workshop / Seminar Tue, 10 Mar 2020 10:49:33 -0400 2020-03-27T12:00:00-04:00 2020-03-27T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials & microscope drawing in yellow on a blue square
Defense: Investigating the Role of Sleep-Dependent Memory Consolidation in Experience Activated Neurons (March 27, 2020 3:00pm) https://events.umich.edu/event/73916 73916-18424548@events.umich.edu Event Begins: Friday, March 27, 2020 3:00pm
Location:
Organized By: Department of Molecular, Cellular, and Developmental Biology

Sleep is critical for memory consolidation, yet the mechanisms which underlie this process are not well understood. There are two main hypotheses on how sleep promotes memory consolidation: the Sleep Homeostasis Hypothesis (SHY) and Active System Consolidation (ASC). SHY posits that during waking experience, the brain forms new memories – creating and strengthening synapses. Unregulated, this process could reach a point of saturation, which would be metabolically expensive and occlude new memory formation. SHY hypothesizes that during sleep, synapses are uniformly scaled, eliminating weak connections while stronger synapses (important memories) persist. In contrast, ASC postulates that sleep synchronizes neural firing, selectively activating (and strengthening) synaptic connections for specific memories – promoting consolidation. Thus, according to the two hypotheses, different synaptic changes are expected across sleep.

Unresolved discrepancies between ACS and SHY may be due to technical limitations. Until recently, techniques have been unavailable to characterize and manipulate the neurons involved in a specific memory. Experimental outcomes have historically relied on data averaged across the neurons in a given brain structure. This lack of resolution has been a major barrier to understanding how sleep promotes memory consolidation. To move beyond these limitations, this thesis employs both in vivo recording of neurons (allowing tracking of memory encoding neurons across behavioral states) and recently developed engram, or memory trace, tools (allowing us to manipulate the activity of neurons encoding a specific memory). These experimental strategies aim to clarify whether SHY or ASC (or both) occur in primary visual cortex (V1) during post-learning sleep, and whether this consolidation is dependent on sleep-specific memory reactivation.

Using neuronal firing rates as a measure of plasticity, we examined the activity of V1 neurons across sleep, sleep deprivation, and post-learning sleep. The learning paradigm used is orientation-specific response potentiation (OSRP) which manifests as selective increases in V1 neuronal responses to a specific orientated grating. All sleep conditions showed an upregulation in the activity of low firing rate neurons and a downregulation of the activity of high firing rate neurons. These low firing rate neurons convey more visual information and selectively express OSRP. This suggests that sleep selectively upregulates the activity of neurons involved in sensory experience while simultaneously downregulating the activity those that are not.

To evaluate the necessity of memory reactivation during sleep for consolidation, we used engram technology to selectively manipulate neurons activated by a specific visual stimulus. We combined visually-cued conditioning to oriented gratings with engram labelling to create a tractable system for manipulating a specific memory during sleep. We show that the TRAP (targeted recombination in active populations) engram mouse line can be used to drive transgene expression in a specific oriented grating ensemble in primary visual cortex. We then inhibit this ensemble during post-conditioning sleep causing impaired consolidation. This was done in a content specific manner without altering sleep architecture or oscillations - indicating that reactivation specifically is necessary for sleep dependent memory consolidation.

This work unites two long standing hypotheses regarding sleep function for brain circuitry - SHY and ASC. The data support a comprehensive model in which sleep selectively reactivates neurons encoding relevant information. This upregulates their activity, while simultaneously decreasing activity in neurons whose information content is not salient. Future work will be needed to understand the molecular, cellular, and network mechanisms which drive these changes in specific cell populations.

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Other Fri, 27 Mar 2020 14:56:00 -0400 2020-03-27T15:00:00-04:00 2020-03-27T17:00:00-04:00 Department of Molecular, Cellular, and Developmental Biology Other MCDB initials and yellow microscope on a blue square
Project Management Certification (March 29, 2020 12:00pm) https://events.umich.edu/event/73563 73563-18261072@events.umich.edu Event Begins: Sunday, March 29, 2020 12:00pm
Location: Ross School of Business
Organized By: Tauber Institute for Global Operations

Once again, the Tauber Institute, in conjunction with the International Project Management Association (IPMA), is sponsoring a Project Management certification class and exam for graduate business and engineering students and staff.

In order to participate, you will need to reflect upon a project management experience (for example a work project, an engineering design experience/senior capstone, Ross' MAP project, Tauber team project, etc). If you cannot make it to the classes (due to project travel, MAP, or other another class), the sessions will be recorded. Homework (mastery verification) will be required after each session.

The cost to an individual to take the exam is normally $595, however, Tauber is offering the exam at a substantial discount to non-Tauber students: $500 and to Tauber students: $150. Certification is valid for 5 years. Three certification classes will be taught by Professor Eric Svaan on the following dates:

Sunday, March 15 (noon - 4:30 pm, Ross R-0420)
Sunday, March 29 (noon - 4:30 pm, Ross R-0420)
Sunday, April 5 (noon - 4:30 pm, Ross R-0420)

The certification exam, administered by IPMA-USA is scheduled for April 26, 2020 (11:00 am) at the Ross School of Business, R-0320. Successfully passing the exam will yield IPMA's Level D certification (Certified Project Management Associate).

Over the last two years, all students who have taken the exam have passed!

Project Management is a powerful skillset to have in your toolbox as you look for full-time employment!

REGISTRATION: Please register through iMpact by clicking here:
http://myumi.ch/dO5Nl

NOTE: The $500 (for non-Tauber students) or $150 fee (for Tauber students) is non-refundable.

HOSTED BY: Tauber Institute for Global Operations. For questions about this event, please contact tauberinstitute@umich.edu or visit tauber.umich.edu.

What is IPMA Level D® (Certified Project Management Associate)? The IPMA Level D is an internationally recognized entry-level qualification in the area of project management. This designation, which demonstrates the individual's ability to understand the basics of project management, is similar to the exam-oriented, knowledge-based certifications of other major Project Management associations. For many, Level D® is the first step towards a professional project or program manager role. It is the first step in a sequence (C, B, and A) to be earned by demonstration of success in larger PM responsibility sets.

For more information,
Visit tauber.umich.edu or call 734-647-1333
Connect via email to Diana Crossley dianak@umich.edu

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Class / Instruction Thu, 05 Mar 2020 10:07:18 -0500 2020-03-29T12:00:00-04:00 2020-03-29T16:30:00-04:00 Ross School of Business Tauber Institute for Global Operations Class / Instruction Photo of certificate
Canceled: EEB Tuesday Lunch Seminar (March 31, 2020 12:00pm) https://events.umich.edu/event/69223 69223-17269227@events.umich.edu Event Begins: Tuesday, March 31, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Please join us for our weekly brown bag lunch seminar.

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Workshop / Seminar Wed, 11 Mar 2020 13:34:52 -0400 2020-03-31T12:00:00-04:00 2020-03-31T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Biological Sciences Building background, UM EEB logo and text reading EEB Tuesday Lunch Seminars
CANCELED: EEB Thursday Seminar: Ecological drivers of plant mating system evolution (April 2, 2020 4:00pm) https://events.umich.edu/event/69048 69048-17220029@events.umich.edu Event Begins: Thursday, April 2, 2020 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

The events that occur during reproduction play a critical role in determining the distribution of genetic and phenotypic variance within populations and thus their potential to adapt and persist. Understanding the forces shaping the evolution of mating patterns and the diversity of traits that influence mating success in the natural world is a fundamental problem in evolutionary biology. Plants, in particular, show an impressive amount of diversity in floral form and the degree to which they outcross or self-pollinate. In this seminar, I will share a series of empirical and modeling studies investigating how the pollination environment drives the evolution of floral traits that promote either outcrossing or selfing.

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Workshop / Seminar Wed, 11 Mar 2020 13:51:12 -0400 2020-04-02T16:00:00-04:00 2020-04-02T17:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Biological Sciences Building
VIRTUAL Residential College Major, Minor and Course Fair for LSA Students (April 2, 2020 5:00pm) https://events.umich.edu/event/61799 61799-18452041@events.umich.edu Event Begins: Thursday, April 2, 2020 5:00pm
Location: Off Campus Location
Organized By: Residential College

Curious about one of the RC's four majors - in Creative Writing and Literature, Social Theory and Practice, Drama, Arts and Ideas in the Humanities - or one of our four minors - Urban Studies, Crime and Justice, Science, Technology and Society, and Text to Performance? Our programs are interdisciplinary and students enjoy the lead role they play in crafting their studies with us.

OPEN TO ALL LSA STUDENTS!

Come to our RC major and minor fair virtually via Zoom Meetings on 4/2 from 5-6pm to learn more.
Find all the Zoom meeting links and details at this page: myumi.ch/O4BdE

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Fair / Festival Fri, 27 Mar 2020 16:17:49 -0400 2020-04-02T17:00:00-04:00 2020-04-02T18:00:00-04:00 Off Campus Location Residential College Fair / Festival LSA Residential College
[FREE- NOW ONLINE!]Great Lakes Theme Semester Presents: #LakeEffects Film Series (April 2, 2020 6:30pm) https://events.umich.edu/event/73624 73624-18272033@events.umich.edu Event Begins: Thursday, April 2, 2020 6:30pm
Location: Off Campus Location
Organized By: Great Lakes Theme Semester

Hosted by Michigan Sea Grant and co-sponsored by Great Lakes Now, this completely free series will have a different theme each night: Journeys, Shipwrecks, Invaders, Hazards, Detroit Public TV Night.

Join us every Thursday for the next five weeks now on Zoom! Join us virtually for an hour and a half screening followed by a brief Q&A with filmmakers, participants, and local experts. We hope to see you there!
https://zoom.us/j/380790681

March 12: Journeys
The Big Five Dive
Crossing Lake Huron

March 19: Shipwrecks
Project Shiphunt
November Requiem

March 26: Invaders
Making Waves

April 2: Hazards
Great Lakes, Bad Lines
The Forever Chemicals

April 9: Detroit Public TV Night
Selections from Great Lakes Now

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Livestream / Virtual Mon, 01 Mar 2021 15:33:59 -0500 2020-04-02T18:30:00-04:00 2020-04-02T21:00:00-04:00 Off Campus Location Great Lakes Theme Semester Livestream / Virtual U-M LSA Great Lakes Theme Semester, Lake Effects, with topographical map of Michigan
CANCELED--Genomes gone wild: Experimental evolution meets synthetic biology (April 3, 2020 12:00pm) https://events.umich.edu/event/72765 72765-18070595@events.umich.edu Event Begins: Friday, April 3, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Andrzej Wierzbicki

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Workshop / Seminar Thu, 12 Mar 2020 08:59:45 -0400 2020-04-03T12:00:00-04:00 2020-04-03T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials microscope drawing on blue square
Project Management Certification (April 5, 2020 12:00pm) https://events.umich.edu/event/73563 73563-18261073@events.umich.edu Event Begins: Sunday, April 5, 2020 12:00pm
Location: Ross School of Business
Organized By: Tauber Institute for Global Operations

Once again, the Tauber Institute, in conjunction with the International Project Management Association (IPMA), is sponsoring a Project Management certification class and exam for graduate business and engineering students and staff.

In order to participate, you will need to reflect upon a project management experience (for example a work project, an engineering design experience/senior capstone, Ross' MAP project, Tauber team project, etc). If you cannot make it to the classes (due to project travel, MAP, or other another class), the sessions will be recorded. Homework (mastery verification) will be required after each session.

The cost to an individual to take the exam is normally $595, however, Tauber is offering the exam at a substantial discount to non-Tauber students: $500 and to Tauber students: $150. Certification is valid for 5 years. Three certification classes will be taught by Professor Eric Svaan on the following dates:

Sunday, March 15 (noon - 4:30 pm, Ross R-0420)
Sunday, March 29 (noon - 4:30 pm, Ross R-0420)
Sunday, April 5 (noon - 4:30 pm, Ross R-0420)

The certification exam, administered by IPMA-USA is scheduled for April 26, 2020 (11:00 am) at the Ross School of Business, R-0320. Successfully passing the exam will yield IPMA's Level D certification (Certified Project Management Associate).

Over the last two years, all students who have taken the exam have passed!

Project Management is a powerful skillset to have in your toolbox as you look for full-time employment!

REGISTRATION: Please register through iMpact by clicking here:
http://myumi.ch/dO5Nl

NOTE: The $500 (for non-Tauber students) or $150 fee (for Tauber students) is non-refundable.

HOSTED BY: Tauber Institute for Global Operations. For questions about this event, please contact tauberinstitute@umich.edu or visit tauber.umich.edu.

What is IPMA Level D® (Certified Project Management Associate)? The IPMA Level D is an internationally recognized entry-level qualification in the area of project management. This designation, which demonstrates the individual's ability to understand the basics of project management, is similar to the exam-oriented, knowledge-based certifications of other major Project Management associations. For many, Level D® is the first step towards a professional project or program manager role. It is the first step in a sequence (C, B, and A) to be earned by demonstration of success in larger PM responsibility sets.

For more information,
Visit tauber.umich.edu or call 734-647-1333
Connect via email to Diana Crossley dianak@umich.edu

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Class / Instruction Thu, 05 Mar 2020 10:07:18 -0500 2020-04-05T12:00:00-04:00 2020-04-05T16:30:00-04:00 Ross School of Business Tauber Institute for Global Operations Class / Instruction Photo of certificate
Canceled: EEB Tuesday Lunch Seminar (April 7, 2020 12:00pm) https://events.umich.edu/event/69226 69226-17269228@events.umich.edu Event Begins: Tuesday, April 7, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Please join us for our weekly brown bag lunch seminar.

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Workshop / Seminar Wed, 11 Mar 2020 13:39:36 -0400 2020-04-07T12:00:00-04:00 2020-04-07T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Biological Sciences Building background, UM EEB logo and text reading EEB Tuesday Lunch Seminars
Defense: The Ins and Outs of Melanopsin Signaling (April 7, 2020 2:00pm) https://events.umich.edu/event/74029 74029-18491691@events.umich.edu Event Begins: Tuesday, April 7, 2020 2:00pm
Location:
Organized By: Department of Molecular, Cellular, and Developmental Biology

Mentor: Kwoon Wong

Abstract: Intrinsically photosensitive retinal ganglion cells (ipRGCs) are responsible for non-image-forming functions such as circadian photoentrainment, pupillary light reflex and the suppression of melatonin. Additionally, their axons innervate two main image-forming visual nuclei: the superior colliculus (SC) and the lateral geniculate nucleus (LGN). Furthermore, electrophysiology data discovered that ipRGCs signal to dopaminergic amacrine cells via AMPA/Kainate glutamate receptors and to displaced amacrine cells (ACs) located in the ganglion cell layer of the retina through gap junctions. Retinal ganglion cells had never been found to signal intraretinally prior to this finding.

Several labs have been exploring how ipRGCs mediate or modulate image-forming vision through their central projections and signaling to dopaminergic ACs. However, little is known about the functional roles of gap-junction signaling from ipRGCs to displaced ACs and how ipRGCs work in conjunction with rod and cone photoreceptors to mediate image-forming visual responses. Neurobiotin tracer injections, immunostaining, and optokinetic visual behavior techniques were used in this thesis to fill in this knowledge gap. Four specific aims were accomplished: 1) understand how ipRGC-coupled ACs are distributed across the retina and identify ipRGC-coupled ACs, 2) test the hypothesis that connexin36 (Cx36) couples ipRGCs to displaced ACs, 3) examine the effect of glutamatergic input on ipRGC-AC coupling, and 4) assess the effect of rods, cones and melanopsin on image-forming behavior.

We found that all six ipRGC types are electrically coupled to amacrine cells, primarily via Cx36 and a few ipRGC-coupled amacrine cells are bNOS, nNOS, NPY or 5-HT immunopositive. ipRGC-AC coupling is enhanced in the presence of NMDA receptor expression in ipRGCs. We found the distribution of ipRGC-coupled amacrine cells is region specific, and rods, cones and melanopsin contribute to image-forming vision differently. Because ipRGCs remain light-sensitive in many blind patients suffering from rod and cone degeneration, a better understanding of the signaling ipRGCs could lead to novel strategies to restore sight in such patients.

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Other Tue, 07 Apr 2020 10:39:55 -0400 2020-04-07T14:00:00-04:00 2020-04-07T16:00:00-04:00 Department of Molecular, Cellular, and Developmental Biology Other yellow microscope on blue square
Canceled: EEB Thursday Seminar: Sex differences in immune function: probing ultimate drivers, and exploring consequences (April 9, 2020 4:00pm) https://events.umich.edu/event/69049 69049-18206121@events.umich.edu Event Begins: Thursday, April 9, 2020 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Humans, like many other species, show striking sex differences in immune function. While the proximate determinants of sex differences across species can include both chromosomal and hormonal differences, the ultimate evolutionary determinants will be rooted in differences in investments in competing and caring between the sexes. Ultimate explanations have classically been framed in terms of quantitative sex differences in immune function (with males typically the ‘weaker’ sex), but have failed to account for qualitative sex differences in immune function. We model immune trade-offs that might underpin these differences. Once the dangerous side of immunity is accounted for, two distinct immunological profiles emerge as peaks on a fitness landscape, one aligned with investment in pathogen detection and the other with investment in pathogen killing. Intriguingly, alignment of these fitness peaks with observed sex differences in birds and mammals – where females typically favor detection – cannot be explained by selection pressures emerging from models including immunity trade-offs alone. Age-specific patterns of infection, and/or maternal transfer of immunity (e.g., maternal antibodies) are also required. The characterization of immune function underlying these predictions is necessarily a simplified caricature of the true complexity. We develop projections of the scope of expectations of this simplified caricature in terms of the development of immunity across the life course in the two sexes.

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Workshop / Seminar Wed, 11 Mar 2020 14:47:30 -0400 2020-04-09T16:00:00-04:00 2020-04-09T17:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Sex differences in immune function - graphs
[FREE- NOW ONLINE!]Great Lakes Theme Semester Presents: #LakeEffects Film Series (April 9, 2020 6:30pm) https://events.umich.edu/event/73624 73624-18272034@events.umich.edu Event Begins: Thursday, April 9, 2020 6:30pm
Location: Off Campus Location
Organized By: Great Lakes Theme Semester

Hosted by Michigan Sea Grant and co-sponsored by Great Lakes Now, this completely free series will have a different theme each night: Journeys, Shipwrecks, Invaders, Hazards, Detroit Public TV Night.

Join us every Thursday for the next five weeks now on Zoom! Join us virtually for an hour and a half screening followed by a brief Q&A with filmmakers, participants, and local experts. We hope to see you there!
https://zoom.us/j/380790681

March 12: Journeys
The Big Five Dive
Crossing Lake Huron

March 19: Shipwrecks
Project Shiphunt
November Requiem

March 26: Invaders
Making Waves

April 2: Hazards
Great Lakes, Bad Lines
The Forever Chemicals

April 9: Detroit Public TV Night
Selections from Great Lakes Now

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Livestream / Virtual Mon, 01 Mar 2021 15:33:59 -0500 2020-04-09T18:30:00-04:00 2020-04-09T21:00:00-04:00 Off Campus Location Great Lakes Theme Semester Livestream / Virtual U-M LSA Great Lakes Theme Semester, Lake Effects, with topographical map of Michigan
Master's Thesis Defense: Mingyang Wang (April 10, 2020 10:30am) https://events.umich.edu/event/73990 73990-18460430@events.umich.edu Event Begins: Friday, April 10, 2020 10:30am
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be held via Blue Jeans. It will be linked before.

BlueJeans: https://bluejeans.com/315155702

Objectives
We have developed a novel anti-vascular technique, termed photo-mediated ultrasound therapy (PUT), which utilizes nanosecond duration laser pulses synchronized with ultrasound bursts to remove microvasculature through cavitation. The objective of the current study is to explore the potential of PUT in removing cutaneous microvessels.

Methods
The auricular blood vessels of two New Zealand white rabbits were treated by PUT with a peak negative ultrasound pressure of 0.45 MPa at 0.5 MHz, and a laser fluence of 0.056 J/cm2 at 1064 nm for 10 minutes. Blood perfusion in the treated area was measured by a commercial laser speckle imaging (LSI) system before and immediately after treatment, as well as at one hour, three days, two weeks, and four weeks post treatment. Perfusion rates of 38 individual vessels from 4 rabbit ears were tracked during this time period for longitudinal assessment.

Results
The measured perfusion rates of the vessels in the treated areas, as quantified by the relative change in perfusion rate (RCPR), showed a statistically significant decrease for all time points post treatment (p<0.001). The mean decrease in perfusion is 50.79% immediately after treatment and is 32.14% at four weeks post treatment. Immediately after treatment, the perfusion rate decreased rapidly. Following this, there was a partial recovery in perfusion rate up to 3 days post treatment, then followed by a plateau in the perfusion from 3 days to 4 weeks.

Conclusions
The study demonstrated that a single PUT treatment could significantly reduce blood perfusion by 32.14% in the skin for up to 4 weeks. With unique advantages such as low laser fluence as compared with photothermolysis and agent-free treatment as compared with PDT, PUT holds potential to be developed into a new tool for the treatment of microvessels in the skin.

Keywords: laser; ultrasound; anti-vascular treatment; skin microvessels; photo-mediated ultrasound therapy

Chair: Dr. Xueding Wang

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Lecture / Discussion Fri, 27 Mar 2020 13:53:59 -0400 2020-04-10T10:30:00-04:00 2020-04-10T11:30:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
CANCELED: How do Fatty Acids Induce Mitochondrial H+ leak and Thermogenesis? (April 10, 2020 12:00pm) https://events.umich.edu/event/72766 72766-18070596@events.umich.edu Event Begins: Friday, April 10, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Haoxing Xu

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Workshop / Seminar Tue, 10 Mar 2020 10:51:44 -0400 2020-04-10T12:00:00-04:00 2020-04-10T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials & microscope drawing in yellow on a blue square
Canceled: EEB Tuesday Lunch Seminar (April 14, 2020 12:00pm) https://events.umich.edu/event/69227 69227-17269230@events.umich.edu Event Begins: Tuesday, April 14, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Please come join us for our weekly brown bag lunch seminar.

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Workshop / Seminar Wed, 11 Mar 2020 13:40:25 -0400 2020-04-14T12:00:00-04:00 2020-04-14T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Biological Sciences Building background, UM EEB logo and text reading EEB Tuesday Lunch Seminars
PhD Defense: Joel Tan (April 14, 2020 2:00pm) https://events.umich.edu/event/73953 73953-18443421@events.umich.edu Event Begins: Tuesday, April 14, 2020 2:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This PhD defense will be taking place via Blue Jeans. Link below.

Blue Jeans: https://bluejeans.com/304616213
Chair: Dr. Xueding Wang

Photoacoustic (PA) imaging is an emerging biomedical imaging modality that combines optical and ultrasound imaging technologies. PA imaging relies on the absorption of electromagnetic energy (usually in the form of visible or near-infrared light) leading to the generation of acoustic waves by thermoelastic expansion, which can be detected with an ultrasound detector. PA imaging can be used to detect endogenous chromophores such as deoxyhemoglobin and oxyhemoglobin, or can be used together with external nanosensors for added functionality. The former is used to measure things like blood oxygenation, while the latter opens up many possibilities for PA imaging, limited only to the availability of optical nanosensors. In this dissertation, I employ the use of PA nanosensors for contrast enhancement and molecular imaging in in vivo small animal cancer models.

In the first section, I introduce a novel PA background reduction technique called the transient triplet differential (TTD) method. The TTD method exploits the fact that phosphorescent dyes possess a triplet state with a unique red-shifted absorption wavelength, distinct from its ordinary singlet state absorption profile. By pumping these dyes into the triplet state and comparing the signal to the unpumped dyes, a differential signal can be obtained which solely originates from these dyes. Since intrinsic chromophores of biological tissue are not able to undergo intersystem crossing and enter the triplet state, the TTD method can facilitate “true” background free molecular imaging by excluding the signals from every other chromophore outside the phosphorescent dye. Here, I demonstrate up to an order of magnitude better sensitivity of the TTD method compared to other existing contrast enhancement techniques in both in vitro experiments and in vivo cancer models.

In the second section, I explore the use of a nanoparticle formulation of a repurposed FDA-approved drug called clofazimine for diagnosis of prostate cancer. Clofazimine nanoparticles have a high optical absorbance at 495 nm and has been known to specifically accumulate in macrophages as they form stable crystal-like inclusions once they are uptaken by macrophages. Due to the presence of tumor associated macrophages, it is expected that clofazimine would accumulate in much higher quantities in the cancerous prostate compared to normal prostates. Here, I show that there was indeed a significantly higher accumulation of clofazimine nanoparticles in cancerous prostates compared to normal prostates in a transgenic mouse model, which was detectable both using histology and ex vivo PA imaging.

In the third and final section, I explore the use of a potassium (K+) nanosensor together with PA imaging in measuring the in vivo K+ distribution in the tumor microenvironment (TME). K+ is the most abundant ion in the body and has recently been shown to be at a significantly higher concentration in the tumor. The reported 5-10 fold elevation (25-50 mM compared to 5 mM) in the tumor has been shown to inhibit immune cell efficacy, and thus immunotherapy. Despite the abundance and importance of K+ in the body, few ways exist to measure it in vivo. In this study, a solvatochromic dye K+ nanoparticle (SDKNP) was used together with PA imaging to quantitatively measure the in vivo distribution of K+ in the TME. Significantly elevated K+ levels were found in the TME, with an average concentration of approximately 29 mM, matching the values found by the previous study. The results were then verified using mass spectrometry.

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Lecture / Discussion Wed, 25 Mar 2020 13:19:15 -0400 2020-04-14T14:00:00-04:00 2020-04-14T15:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Canceled: EEB Thursday Seminar: Chuck Davis (April 16, 2020 4:00pm) https://events.umich.edu/event/69050 69050-17220031@events.umich.edu Event Begins: Thursday, April 16, 2020 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

To be postponed at this time.

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Workshop / Seminar Wed, 11 Mar 2020 13:07:59 -0400 2020-04-16T16:00:00-04:00 2020-04-16T17:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Biological Sciences Building
Canceled: EEB Tuesday Lunch Seminar (April 21, 2020 12:00pm) https://events.umich.edu/event/69229 69229-17269231@events.umich.edu Event Begins: Tuesday, April 21, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Please join us for our weekly brown bag lunch seminar.

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Workshop / Seminar Wed, 11 Mar 2020 13:41:34 -0400 2020-04-21T12:00:00-04:00 2020-04-21T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Biological Sciences Building background, UM EEB logo and text reading EEB Tuesday Lunch Seminars
Master's Defense: Jonathan Primeaux (April 21, 2020 2:30pm) https://events.umich.edu/event/74331 74331-18633862@events.umich.edu Event Begins: Tuesday, April 21, 2020 2:30pm
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be held via Zoom. The link will be placed below.

Zoom Link: https://umich.zoom.us/j/7013698675

Children with hypoplastic left heart syndrome (HLHS) must undergo multiple surgical stages to reconstruct the anatomy to a sustainable single ventricle system. Stage I palliation, or the Norwood procedure, enables circulation to both pulmonary and systemic vasculature. The aorta is reconstructed and attached to the right ventricle and a fraction of systemic flow is redirected to the pulmonary arteries (PAs) through a systemic-to-pulmonary artery shunt. Despite abundant hemodynamic data available 4-5 months after palliation, data is very scarce immediately following stage I. This data is critical in determining post-operative success. In this work, we combined population data and computational fluid dynamics (CFD) to characterize hemodynamics immediately following stage I (post-stage I) and prior to stage II palliation (pre-stage II). A patient-specific model was constructed as a baseline geometry, which was then scaled to reflect population-based morphological data at both time-points. Population-based hemodynamic data was also used to calibrate each model to reproduce blood flow representative of HLHS patients.

The post-stage I simulation produced a mean PA pressure of 22 mmHg and high-frequency oscillations within the flow field indicating highly disturbed hemodynamics. Despite mean PA pressure dropping to 14 mmHg, the pre-stage II model also produced high-frequency flow components and PA wall shear stress increases. These suboptimal conditions result from the need to ensure adequate PA flow throughout the pre-stage II period, as the shunt becomes relatively smaller compared to the growing patient size. In the future, CFD can be used to optimize shunt design and minimize these suboptimal conditions.

Chair: Dr. Alberto Figueroa

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Lecture / Discussion Fri, 17 Apr 2020 13:05:00 -0400 2020-04-21T14:30:00-04:00 2020-04-21T15:30:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Master's Defense: Xijia Quan (April 21, 2020 3:00pm) https://events.umich.edu/event/74183 74183-18559840@events.umich.edu Event Begins: Tuesday, April 21, 2020 3:00pm
Location:
Organized By: Biomedical Engineering

NOTICE: This event will be held via Blue Jeans. The link will be posted below.

Blue Jeans link: https://bluejeans.com/6788336326

We propose a novel optimization algorithm for radiofrequency (RF) pulse design in magnetic resonance imaging (MRI), that regularizes the magnitude and phase of the target (desired) magnetization pattern separately. This approach may be useful across applications where the relative importance of achieving accurate magnitude or phase excitation varies; for example, saturation pulses "care" only about the magnitude excitation pattern. We apply our new design to the problem of spin "prephasing" in 3D functional MRI using blood-oxygen-level-dependent (BOLD) contrast; spin prephasing pulses can mitigate the signal loss observed near air/tissue boundaries due to the presence of local susceptibility gradients. We show that our algorithm can improve the simulation performance and recover some signal in some regions with steep susceptibility gradients. In all cases, our algorithm shows better phase correction than a conventional design based on minimizing the complex difference between the target and realized patterns. The algorithm is open-source and the computation time is feasible for online applications. In addition, we evaluate the impact of the choice of (initial) excitation k-space trajectories, both in terms of trajectory type (SPINS vs extended KT points) and overall pulse duration.

Chair: Dr. Jon-Fredrik Nielsen

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Lecture / Discussion Thu, 09 Apr 2020 14:11:30 -0400 2020-04-21T15:00:00-04:00 2020-04-21T16:00:00-04:00 Biomedical Engineering Lecture / Discussion BME Logo
CANCELLED Neuroscience and Biological Sciences Poster Session (April 22, 2020 3:00pm) https://events.umich.edu/event/61658 61658-18015958@events.umich.edu Event Begins: Wednesday, April 22, 2020 3:00pm
Location: Undergraduate Science Building
Organized By: Program in Biology

You are invited to the 2020 Bio./Neuro. Poster Session in which undergraduate students showcase the results of their theses and independent research projects.

Wednesday, April 22, 2020,
in the Undergraduate Science Building (USB) , 3:00-4:30 pm.

The event is always well-attended and a lot of fun (a chance to socialize with faculty and fellow majors).

All undergraduates, faculty, and staff are invited to stop by!

Interested in presenting?

To present in the poster session, a student must have a completed (or almost completed) an advisor-approved independent research project. Poster sessions are commonly held at scientific conferences; participating in April will allow students to gain valuable professional experience!
Students who wish to participate in the poster session are expected to design and (professionally) print out a poster that they will present to other students, faculty, and guests at the session.
This is a wonderful opportunity for students pursuing an honors degree to present their research in a public forum, but it is also open to anyone with an approved independent research project!

If you are a student interested in participating, please RSVP (by April 10).
https://umich.qualtrics.com/jfe/form/SV_6SfFBl735zcfFaY

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Exhibition Tue, 24 Mar 2020 10:45:37 -0400 2020-04-22T15:00:00-04:00 2020-04-22T16:30:00-04:00 Undergraduate Science Building Program in Biology Exhibition Poster Session
PhD Defense: David Martel (April 22, 2020 3:00pm) https://events.umich.edu/event/74201 74201-18568320@events.umich.edu Event Begins: Wednesday, April 22, 2020 3:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be held via Zoom. The link will be provided below.

Zoom: https://umich.zoom.us/j/2019377962

Tinnitus is the disorder of phantom sound perception, while hyperacusis is abnormally increased loudness growth. Tinnitus and hyperacusis are both associated with hearing loss, but hearing loss does not always occur with either condition, implicating central neural activity as the basis for each disorder. Furthermore, while tinnitus and hyperacusis can co-occur, either can occur exclusively, suggesting that separate pathological neural processes underlie each disorder.

Mounting evidence suggests that pathological neural activity in the cochlear nucleus, the first central nucleus in the auditory pathway, underpins hyperacusis and tinnitus. The cochlear nucleus is comprised of a ventral and dorsal subdivision, which have separate principle output neurons with distinct targets. Previous studies have shown that dorsal cochlear nucleus fusiform cells show tinnitus-related increases in spontaneous firing with minimal alterations to sound-evoked responses. In contrast, sound-evoked activity in ventral cochlear nucleus bushy cells is enhanced following noise-overexposure, putatively underlying hyperacusis. While the fusiform-cell contribution to tinnitus has been well characterized with behavioral and electrophysiological studies, the bushy-cell contribution to tinnitus or hyperacusis has been understudied.

This dissertation examines how pathological neural activity in cochlear nucleus circuitry relates to tinnitus and hyperacusis in the following three chapters.

In the first chapter, I characterize the development of a high-throughput tinnitus behavioral model, which combines and optimizes existing paradigms. With this model, I show that animals administered salicylate, a drug that reliably induces tinnitus at high doses in both humans and animals, show behavioral evidence of tinnitus in two separate behavioral tests. Moreover, in these same animals, I show that dorsal-cochlear-nucleus fusiform cells exhibit frequency-specific increases in spontaneous firing activity, consistent with noise-induced tinnitus in animals.

In the second chapter, I show that following noise-overexposure, ventral-cochlear-nucleus bushy cells demonstrate hyperacusis-like neural firing patterns, but not tinnitus-specific increases in spontaneous activity. I contrast the bushy-cell neural activity with established fusiform-cell neural signatures of tinnitus, to highlight the bushy-cell, but not fusiform-cell contribution to hyperacusis. These analyses suggest that tinnitus and hyperacusis likely arise from distinct neural substrates.

In the third chapter, I use computational modelling of the auditory periphery and bushy-cell circuitry to examine potential mechanisms that underlie hyperacusis-like neural firing patterns demonstrated in the second chapter. I then relate enhanced bushy-cell firing patterns to alterations in the auditory brainstem response, a sound-evoked electrical potential generated primarily by bushy cells. Findings in this chapter suggest that there are multiple hyperacusis subtypes, arising from separate mechanisms, which could be diagnosed through fine-tuned alterations to the auditory brainstem response.

Chair: Dr. Susan Shore

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Lecture / Discussion Thu, 09 Apr 2020 14:17:07 -0400 2020-04-22T15:00:00-04:00 2020-04-22T16:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Defense: Analysis of the Dstac Gene, a Novel Regulator of Neuronal Function and Behavior in Drosophila Melanogaster (April 24, 2020 1:30pm) https://events.umich.edu/event/74347 74347-18658199@events.umich.edu Event Begins: Friday, April 24, 2020 1:30pm
Location:
Organized By: Department of Molecular, Cellular, and Developmental Biology

Mentor: John Kuwada

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Workshop / Seminar Thu, 23 Apr 2020 17:57:13 -0400 2020-04-24T13:30:00-04:00 2020-04-24T15:30:00-04:00 Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials and yellow microscope on a blue square
Project Management Certification (April 26, 2020 11:00am) https://events.umich.edu/event/73563 73563-18261074@events.umich.edu Event Begins: Sunday, April 26, 2020 11:00am
Location: Ross School of Business
Organized By: Tauber Institute for Global Operations

Once again, the Tauber Institute, in conjunction with the International Project Management Association (IPMA), is sponsoring a Project Management certification class and exam for graduate business and engineering students and staff.

In order to participate, you will need to reflect upon a project management experience (for example a work project, an engineering design experience/senior capstone, Ross' MAP project, Tauber team project, etc). If you cannot make it to the classes (due to project travel, MAP, or other another class), the sessions will be recorded. Homework (mastery verification) will be required after each session.

The cost to an individual to take the exam is normally $595, however, Tauber is offering the exam at a substantial discount to non-Tauber students: $500 and to Tauber students: $150. Certification is valid for 5 years. Three certification classes will be taught by Professor Eric Svaan on the following dates:

Sunday, March 15 (noon - 4:30 pm, Ross R-0420)
Sunday, March 29 (noon - 4:30 pm, Ross R-0420)
Sunday, April 5 (noon - 4:30 pm, Ross R-0420)

The certification exam, administered by IPMA-USA is scheduled for April 26, 2020 (11:00 am) at the Ross School of Business, R-0320. Successfully passing the exam will yield IPMA's Level D certification (Certified Project Management Associate).

Over the last two years, all students who have taken the exam have passed!

Project Management is a powerful skillset to have in your toolbox as you look for full-time employment!

REGISTRATION: Please register through iMpact by clicking here:
http://myumi.ch/dO5Nl

NOTE: The $500 (for non-Tauber students) or $150 fee (for Tauber students) is non-refundable.

HOSTED BY: Tauber Institute for Global Operations. For questions about this event, please contact tauberinstitute@umich.edu or visit tauber.umich.edu.

What is IPMA Level D® (Certified Project Management Associate)? The IPMA Level D is an internationally recognized entry-level qualification in the area of project management. This designation, which demonstrates the individual's ability to understand the basics of project management, is similar to the exam-oriented, knowledge-based certifications of other major Project Management associations. For many, Level D® is the first step towards a professional project or program manager role. It is the first step in a sequence (C, B, and A) to be earned by demonstration of success in larger PM responsibility sets.

For more information,
Visit tauber.umich.edu or call 734-647-1333
Connect via email to Diana Crossley dianak@umich.edu

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Class / Instruction Thu, 05 Mar 2020 10:07:18 -0500 2020-04-26T11:00:00-04:00 2020-04-26T16:30:00-04:00 Ross School of Business Tauber Institute for Global Operations Class / Instruction Photo of certificate
Pathways Master's Defense: Effects of Carboxysome Mispositioning on Carboxysome Function and Cellular Physiology in the Model Organism Synechococcus elongatus PCC7942 (April 27, 2020 9:00am) https://events.umich.edu/event/74348 74348-18658200@events.umich.edu Event Begins: Monday, April 27, 2020 9:00am
Location:
Organized By: Department of Molecular, Cellular, and Developmental Biology

Mentor: Anthony Vecchiarelli

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Workshop / Seminar Mon, 20 Apr 2020 16:19:42 -0400 2020-04-27T09:00:00-04:00 2020-04-27T11:00:00-04:00 Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials and yellow microscope on a blue square
Canceled: EEB Tuesday Lunch Seminar (April 28, 2020 12:00pm) https://events.umich.edu/event/69230 69230-17269232@events.umich.edu Event Begins: Tuesday, April 28, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Tuesday Lunch Seminars will resume next Fall semester.

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Workshop / Seminar Wed, 11 Mar 2020 13:43:19 -0400 2020-04-28T12:00:00-04:00 2020-04-28T13:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Biological Sciences Building background, UM EEB logo and text reading EEB Tuesday Lunch Seminars
PhD Defense: Richard Youngblood (April 29, 2020 2:00pm) https://events.umich.edu/event/74358 74358-18666222@events.umich.edu Event Begins: Wednesday, April 29, 2020 2:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be held via Blue Jeans. The link will be posted below.

BlueJeans: https://bluejeans.com/855683101

Human pluripotent stem cells (hPSCs) differentiated into complex three-dimensional (3D) structures, referred to as ‘organoids’ due to their organ-like properties, offer ideal platforms to study human development, disease and regeneration. However, studying organ morphogenesis has been hindered by the lack of appropriate culture systems that can spatially enable cellular interactions that are needed for organ formation. Many organoid cultures rely on decellularized extracellular matrices as supportive scaffolds, which are often poorly chemically defined and allow only limited tunability and reproducibility. By contrast, engineered synthetic matrices can be tuned and optimized to mimic the embryo environment in order to enhance development and maturation of organoid cultures. Herein, this work primarily focuses on using synthetic polymer matrices to investigate how the design of biomaterials can guide key interactions guiding stem-cell decisions for the reproducible generation and control of organoid cultures.
Microporous biomaterials comprised of synthetic polymer materials were shown to guide the assembly of pancreatic progenitors into insulin-producing clusters that further developed into islet organoids. The scaffold culture facilitated cell-cell interactions enabled by the scaffold design and supported cell-mediated matrix deposition of extracellular matrix (ECM) proteins associated with the basement membrane of islet cells. Furthermore, when compared to suspension cultures, the scaffold culture showed increased insulin secretion in response to glucose stimulus indicating the development of functional β-cells. By modifying the stage that cells were seeded on scaffolds from pancreatic progenitor to pancreatic endoderm, islet organoids showed increased amounts of insulin secreted per cell. In addition, seeding scaffolds with dense clusters instead of a single suspension minimized cell manipulation during the differentiation, which was shown to be influential to the development of the islet organoids. An engineered insulin reporter further identified how mechanistic changes in vitro influenced function within individual cells by measuring insulin storage and secretion through non-invasive imaging.
hPSC-derived lung organoids (HLOs) were also evaluated for in vivo maturation on biomaterial scaffolds, where HLOs were shown improved tissue structure and cellular differentiation. Investigative studies demonstrated that scaffold pore interconnectivity and polymer degradation contributed to in vivo maturation, the size of the airway structures and the total size of the transplanted tissue. Polymer biomaterials were also developed to modulate local tissue and systemic inflammation through local delivery of human interleukin 4 (hIL-4)-expressing lentivirus. Microporous scaffold culture strategies improve organoid complexity and exert fine control over the system using engineering solutions, thus, allowing the community to build more realistic organoid tools. Taken together, the microporous scaffold culture demonstrates the feasibility to translate organoid culture to the clinic as a biomanufacturing platform.

Chair: Dr. Lonnie Shea

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Lecture / Discussion Tue, 21 Apr 2020 13:21:55 -0400 2020-04-29T14:00:00-04:00 2020-04-29T15:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Master's Defense: Manan Parag Anjaria (April 30, 2020 1:15pm) https://events.umich.edu/event/74435 74435-18714559@events.umich.edu Event Begins: Thursday, April 30, 2020 1:15pm
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be held via Blue Jeans. The link will be provided below.

Blue Jeans Link: https://bluejeans.com/126133694

Individual muscle contributions to facilitate limb motion are altered in people with transtibial amputation. Specifically, proximal muscles on the residual limb and muscles on the intact limb compensate for the lack of plantarflexor muscles on the residual limb. Powered ankle prostheses have been developed to replace the function of the ankle plantarflexor muscles. As powered prostheses can help people with amputation walk faster, and replicate local ankle joint mechanics similar to biological ankles, we expect that muscle activity would also differ when using powered prostheses compared to unpowered prosthesis. Exploring muscle synergies, or the patterns of co-activation of muscles recruited by a single neural command signal, can provide insight into the neural control strategies used to walk with different types of prostheses. The goal of this study was to determine if the use of a powered ankle prosthesis affected muscle coordination and coactivation in comparison to the use of unpowered prosthesis. Nine people with unilateral transtibial amputation and 9 age-matched, non-amputee controls walked on a treadmill while muscle activity from 16 lower limb muscles were collected. Participants with amputation performed two trials, one with an unpowered and one with a powered prosthesis, on the same day. People with transtibial amputation had higher thigh muscle co-contraction when walking with powered prostheses. They also had the same number of synergies in both prostheses as the non-amputee group, which suggests that the complexity of the motor control strategy is not affected by amputation or prosthesis type. The first three synergies in the intact limb were similar, however, the contribution of different muscles to the fourth synergy varied in people with amputation as they used more knee flexors than ankle dorsiflexors in the late swing phase. We also explored the time-varying pattern of the synergies across the gait cycle. There were some phases of the gait cycle where activation profiles for all the synergies were significantly different between the groups with and without amputation. However, there were strong correlations between muscle weightings for each synergy between the groups with and without amputation, with both prostheses. This indicates that they used a similar muscle recruitment strategy. The use of powered prosthesis reduced the compensatory activity of the proximal muscles making the intact limb synergies muscle weightings more similar to healthy individuals with prolonged or delayed activation profiles. The study could not offer any interpretations of the synergies of the residual limb due to lesser muscle activity data available. Future work should be focused including a larger set of muscles including the lumbar muscles and residual leg muscles to get a better look at the muscle synergy.

Chair: Dr. Deanna Gates

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Lecture / Discussion Mon, 27 Apr 2020 13:44:40 -0400 2020-04-30T13:15:00-04:00 2020-04-30T14:15:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
EEB dissertation defense: Virus prevalence in pollinator communities: The role of communities, environments, and host interactions on multi-host–multi-pathogen dynamics (May 1, 2020 10:00am) https://events.umich.edu/event/74280 74280-18617481@events.umich.edu Event Begins: Friday, May 1, 2020 10:00am
Location: Off Campus Location
Organized By: Ecology and Evolutionary Biology

Michelle presents her dissertation

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Livestream / Virtual Thu, 30 Apr 2020 08:30:25 -0400 2020-05-01T10:00:00-04:00 2020-05-01T11:00:00-04:00 Off Campus Location Ecology and Evolutionary Biology Livestream / Virtual A bee pollinating pink flowers on a tree, blue sky
**CANCELLED** Program in Biology Commencement Ceremony (May 1, 2020 3:00pm) https://events.umich.edu/event/61671 61671-18015959@events.umich.edu Event Begins: Friday, May 1, 2020 3:00pm
Location: Off Campus Location
Organized By: Program in Biology

If you are graduating this term (or Summer), congratulations!!

You and your family are invited to the winter commencement ceremony to be held May 1, 2020.

The invitation and RSVP can be found here. (Note that times and locations are different for different majors.)
https://umich.qualtrics.com/jfe/form/SV_3IO2hw4DiFFMY0k

Please respond by April 1, so that guest numbers can be confirmed.

Please email lsa-biology-advising@umich.edu with any questions.

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Ceremony / Service Tue, 24 Mar 2020 10:43:43 -0400 2020-05-01T15:00:00-04:00 2020-05-01T17:00:00-04:00 Off Campus Location Program in Biology Ceremony / Service Graduates
CANCELLED Neuroscience Commencement Ceremony (May 2, 2020 6:00pm) https://events.umich.edu/event/61672 61672-18015960@events.umich.edu Event Begins: Saturday, May 2, 2020 6:00pm
Location: Off Campus Location
Organized By: UPiN - Undergrad. Neuroscience Program

If you are graduating this term (or Summer), congratulations!!

You and your family are invited to the winter commencement ceremony to be held May 2, 2020.

The invitation and RSVP can be found here.
https://umich.qualtrics.com/jfe/form/SV_3UyrLLSASbtActL

Please respond by April 1, so that guest numbers can be confirmed.

Please email lsa-biology-advising@umich.edu for questions.

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Ceremony / Service Tue, 24 Mar 2020 10:46:41 -0400 2020-05-02T18:00:00-04:00 2020-05-02T19:30:00-04:00 Off Campus Location UPiN - Undergrad. Neuroscience Program Ceremony / Service Michigan Theater
EEB thesis defense: Behavioral variation in fox squirrels (Sciurus niger) along an urbanization gradient (May 5, 2020 12:00pm) https://events.umich.edu/event/73304 73304-18190736@events.umich.edu Event Begins: Tuesday, May 5, 2020 12:00pm
Location: Off Campus Location
Organized By: Ecology and Evolutionary Biology

Charlotte defends her master's thesis.

Image: Corey Seeman

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Livestream / Virtual Tue, 21 Apr 2020 18:12:31 -0400 2020-05-05T12:00:00-04:00 2020-05-05T13:00:00-04:00 Off Campus Location Ecology and Evolutionary Biology Livestream / Virtual squirrel in a tree with green tags on ears
PhD Defense: Xianglong Wang (May 5, 2020 1:00pm) https://events.umich.edu/event/74357 74357-18666221@events.umich.edu Event Begins: Tuesday, May 5, 2020 1:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be via Zoom. The link will be provided below.

Zoom: https://umich.zoom.us/j/99315883529

Biological transport processes often involve a boundary acting as separation of flow, most commonly in transport involving blood-contacting medical devices. The separation of flow creates two different scenarios of mass transport across the interface. No flow exists within the medical device and diffusion governs mass transport; both convection and diffusion exist when flow is present. The added convection creates a large concentration gradient around the interface. Computer simulation of such cases prove to be difficult and require proper shock capturing methods for the solutions to be stable, which is typically lacking in commercial solvers. In this talk, we propose a second-order accurate numerical method for solving the convection-diffusion equation by using a gradient-limited Godunov-type convective flux and the multi-point flux approximation (MPFA) L-Method for the diffusion flux. We applied our solver towards simulation of a nitric oxide-releasing intravascular catheter.

Intravascular catheters are essential for long-term vascular access in both diagnosis and treatment. Use of catheters are associated with risks for infection and thrombosis. Risk management dictates that the catheters to be often replaced on a 3 to 5-day cycle, which is bothersome to both patients and physicians. Nitric oxide (NO) is a potent antimicrobial and antithrombotic agent produced by vascular endothelial cells. The production level in vivo is so low that the physiological effects can only be seen around the endothelial cells. The catheter can incorporate a NO source in two major ways: by impregnating the catheter with NO-releasing compounds such as S-nitroso-N-acetyl penicillamine (SNAP) or using electrochemical reactions to generate NO from nitrites. We applied our solver to both situations to guide the design of the catheter.

Lung edema is often present in patients with end-stage renal disease due to reduced filtration functions of the kidney. These patients require regular dialysis sessions to manage their fluid status. The clinical gold standard to quantify lung edema is to use CT, which exposes patients to high amounts of radiation and is not cost efficient. Fluid management in such patients becomes very challenging without a clear guideline of fluid to be removed during dialysis sessions. Aggressive fluid removal can cause both exacerbations of congestive failure and hypotension resulting from low blood volume.

Recently, reverberations in ultrasound signals, referred to as “lung ultrasound comets” have emerged as a potential quantitative way to measure lung edema. Increased presence of lung comets is associated with higher amounts of pulmonary edema, higher mortality, and more adverse cardiac events. However, the lung comets are often counted by hand by physicians with single frames in lung ultrasound and high subjectivity has been found to exist among the counting by physicians. We applied image processing and neural network techniques as an attempt to provide an objective and accurate measurement of the amount of lung comets present. Our quantitative results are significantly correlated with a few clinical parameters, including diastolic blood pressure and ejection fraction.

Co-Chairs: Dr. Joseph Bull and Dr. Alberto Figueroa

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Lecture / Discussion Tue, 21 Apr 2020 13:16:12 -0400 2020-05-05T13:00:00-04:00 2020-05-05T14:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Ph.D. Defense: Kevin Hughes (May 8, 2020 10:00am) https://events.umich.edu/event/74436 74436-18714560@events.umich.edu Event Begins: Friday, May 8, 2020 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be held via Blue Jeans. The link will be provided below.

Blue Jeans Link: https://bluejeans.com/302652230

A variety of immunological disorders are characterized by inappropriate responses to innocuous protein. This is particularly relevant in autoimmune disease, allergy, and transplant rejection. For these, the therapeutic options that exist are minimal or involve broadly immunosuppressive regimens which are often characterized by undesirable side effects. This dissertation highlights advances in the design of a biodegradable poly-lactide-co-glycolide (PLG) nanoparticle (NP) platform to provide antigen-specific tolerance in these disease models.

Strategies to incorporate multiple antigens conjugated to bulk PLG were investigated in a murine model of multiple sclerosis with the observation that a minimum antigen loading of 8µg of antigen per mg of nanoparticle was sufficient to induce maximally observed efficacy. Insights gathered from development of these particles were critical to the design of experiments related to food allergy in mice. Importantly, we demonstrate that it is possible to delivery peanut extract via nanoparticles intravenously without induction of anaphylactic response. Prophylactic and therapeutic administration of particles resulted in improved clinical outcomes and reduction in Th2 markers, including IL-4, IL-5, and IL-13. Interestingly, administration of PLG NPs to deliver allergen did not induce skewing of immunological responses towards Th1/Th17, which is a common approach to treat allergy in pre-clinical models and certain clinical immunotherapy regimens. Studies in a murine model of allogeneic skin transplant rejection demonstrated that the method of incorporation of antigen into the PLG NP resulted in statistically significant delay in graft rejection. These studies also demonstrated shortcomings in the platform’s ability to completely prevent rejection, which we hypothesize is the result of an inability to prevent direct rejection.

Development of FasL-conjugated implantable polymeric discs provided an immunologically privileged site on which to transplant islet cells, which may represent an opportunity to supplement tolerogenic therapies like our PLG NPs. A similar polymeric, implantable technology was designed to enable analysis of the function of inflammatory immune cells, a novel finding which has provided a method to monitor disease progression and response to therapy in a murine model of multiple sclerosis. Collectively, this work has provided several novel strategies to improve polymeric nanoparticle therapies and an implantable, biodegradable platform that shows promise as a companion diagnostic for therapies that impact immune function, including PLG NPs.

Chair: Dr. Lonnie Shea

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Lecture / Discussion Mon, 27 Apr 2020 13:54:09 -0400 2020-05-08T10:00:00-04:00 2020-05-08T11:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Defense: Mechanisms of DNA Modification-Dependent Regulation in Gram-Positive Bacteria (May 14, 2020 1:30pm) https://events.umich.edu/event/74591 74591-18845182@events.umich.edu Event Begins: Thursday, May 14, 2020 1:30pm
Location:
Organized By: Department of Molecular, Cellular, and Developmental Biology

Mentor: Lyle Simmons

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Workshop / Seminar Wed, 13 May 2020 18:04:58 -0400 2020-05-14T13:30:00-04:00 2020-05-14T15:30:00-04:00 Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar yellow microscope and MCDB initials on a blue square
EEB dissertation defense: Testing the proximate mechanisms of character displacement in the evolution of root traits (May 19, 2020 2:00pm) https://events.umich.edu/event/73544 73544-18258846@events.umich.edu Event Begins: Tuesday, May 19, 2020 2:00pm
Location: Off Campus Location
Organized By: Ecology and Evolutionary Biology

Sara defends her doctoral dissertation

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Livestream / Virtual Mon, 11 May 2020 13:25:36 -0400 2020-05-19T14:00:00-04:00 2020-05-19T15:00:00-04:00 Off Campus Location Ecology and Evolutionary Biology Livestream / Virtual hand holding up a small green plant and roots with tag, black background