Happening @ Michigan https://events.umich.edu/list/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. Coded Bias - Free Film Screening (April 14, 2021 12:01am) https://events.umich.edu/event/83579 83579-21430623@events.umich.edu Event Begins: Wednesday, April 14, 2021 12:01am
Location: Off Campus Location
Organized By: Information Assurance

The U-M Dissonance Event Series invites you to watch a free, on-demand screening of the documentary film Coded Bias. Watch Coded Bias on-demand anytime between Thursday, April 8, through Wednesday, April 14.

Visit the Dissonance events page to learn more, watch the trailer and receive the passcode you will need to access Coded Bias and watch the film for free.

https://safecomputing.umich.edu/events/dissonance/coded-bias-free-movie-viewing

Please also join us over Zoom on Thursday, April 15 at 4 p.m. EST for an "At the Movies" style panel discussion of the film Coded Bias. A panel of U-M experts will exchange views on the challenges presented by technologies that reflect the systemic biases in American society.

Links to the panel discussion can be found on the same event link above and on Happenings at Michigan on Thursday, April 15.

Access to Coded Bias and the panel discussion are brought to you by the Dissonance Event Series, ITS Information Assurance, the U-M School of Information, and the Law School’s Privacy and Technology Law Association.

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Film Screening Fri, 09 Apr 2021 14:43:58 -0400 2021-04-14T00:01:00-04:00 2021-04-14T23:59:00-04:00 Off Campus Location Information Assurance Film Screening Dissonance Event Series: Free Screening of the Film Coded Bias
Become a UROP Summer Research Mentor (April 14, 2021 7:00am) https://events.umich.edu/event/82262 82262-21060634@events.umich.edu Event Begins: Wednesday, April 14, 2021 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Submit a Research Project: https://lsa.umich.edu/urop/research-mentors.html

UROP Research Mentors are faculty and post-doc researchers who provide undergraduate student researchers an opportunity to engage in research activities that help them learn about the pursuit of knowledge within an academic discipline. This early exposure to research fosters a valuable academic experience for students. Through this collaboration, students gain research skills and mentorship that lead to academic retention, a more positive undergraduate experience and paths to graduate school.

Summer research mentors will collaborate with UROP students participating in 10-week full time Summer Fellowships.

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Other Wed, 21 Apr 2021 14:43:33 -0400 2021-04-14T07:00:00-04:00 2021-04-14T23:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Other Become a UROP Mentor
Free Coffee and Donuts on North Campus! (April 14, 2021 10:00am) https://events.umich.edu/event/80607 80607-20885818@events.umich.edu Event Begins: Wednesday, April 14, 2021 10:00am
Location: Duderstadt Center
Organized By: Engineering Office of Student Affairs

Are you looking for an opportunity to see what events are happening on campus? Do you need an excuse to leave your room? Do you just love free donuts? If you answered yes to any of these questions we have the right place for you!

In partnership with MDining, the College of Engineering will be providing free coffee and donuts every Wednesday morning in the Duderstadt Connector from 10am-11am.

We invite all students who are currently on campus and using the ResponsiBLUE App to safely enter our buildings to stop by and grab a coffee/juice an or donut To Go!

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Reception / Open House Wed, 27 Jan 2021 09:20:26 -0500 2021-04-14T10:00:00-04:00 2021-04-14T11:00:00-04:00 Duderstadt Center Engineering Office of Student Affairs Reception / Open House Three Panera box shaped coffee jugs in a row labled left to right, hot h2o, decaf, and coffee. A hand is pictured pouring coffee from the right most jug into a coffee cup that the person is holding. The jugs are on a table with bagels in baskets in the background.
INCORPORATING DEI INTO ENGINEERING EDUCATION (April 14, 2021 11:00am) https://events.umich.edu/event/83663 83663-21452154@events.umich.edu Event Begins: Wednesday, April 14, 2021 11:00am
Location: Off Campus Location
Organized By: Aerospace Engineering

The Department of Aerospace Engineering is hosting a panel discussion on using our position as faculty to incorporate and address diversity, equity and inclusion in the classroom. Our panelists feature professors across multiple departments at the University of Michigan including Aerospace, Kinesiology, and Materials Science and Engineering. We hope that you learn from our panelists' successes and challenges in incorporating DEI into their coursework, and leave this event inspired and motivated to incorporate similar methods into your own classes. This event is open to both faculty and students! If you have questions, please contact Professor Quim Martins, Aerospace Engineering DEI Committee Chair (jrram@umich.edu).

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Livestream / Virtual Fri, 09 Apr 2021 11:27:39 -0400 2021-04-14T11:00:00-04:00 2021-04-14T12:30:00-04:00 Off Campus Location Aerospace Engineering Livestream / Virtual INCORPORATING DEI INTO ENGINEERING EDUCATION
Can Education Innovation at Michigan Medicine Benefit from Being More Cohesive? (April 14, 2021 12:00pm) https://events.umich.edu/event/83220 83220-21314487@events.umich.edu Event Begins: Wednesday, April 14, 2021 12:00pm
Location: Off Campus Location
Organized By: RISE (Research. Innovation. Scholarship. Education.)

RISE invites you attend the Virtual Talking Circle (VTC) to contribute your input in co-creating a cohesive pathway for education innovation across health science education at Michigan Medicine.  We invite you to attend and provide your input into this conversation.

Please invite your colleagues who may also be interested. See you then!

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Workshop / Seminar Wed, 24 Mar 2021 14:31:47 -0400 2021-04-14T12:00:00-04:00 2021-04-14T13:00:00-04:00 Off Campus Location RISE (Research. Innovation. Scholarship. Education.) Workshop / Seminar RISE Virtual Talking Circle
Assessing the Progress of Diversity, Equity, and Inclusion Initiatives in the College of Engineering: Student Perceptions of the Climate at the University of Michigan (April 14, 2021 3:30pm) https://events.umich.edu/event/83292 83292-21367800@events.umich.edu Event Begins: Wednesday, April 14, 2021 3:30pm
Location: Off Campus Location
Organized By: Engineering Education Research

The University of Michigan College of Engineering is nearing the end of its five-year strategic plan to improve the climate on campus with regards to Diversity, Equity, and Inclusion (DEI). As part of that plan, focus groups were held with students across every department and program in the College of Engineering, to gather qualitative data that can serve as metrics to consider how the DEI strategic plan is progressing. Over thirty focus groups were held with more than 220 undergraduate and graduate students across the College in the 2019-2020 and 2020-2021 academic years. Students were asked about various elements of their perception of DEI, including factors that impacted their sense of inclusion, if they had been treated differently based on their identity, and their perceptions of the College and their department with regards to diversity. The data collected in these focus groups illuminates the nuance and complexity of the engineering student experience, and how that experience, and their perceptions of DEI in the College, can vary based on their identities and home department.

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Lecture / Discussion Mon, 29 Mar 2021 10:00:26 -0400 2021-04-14T15:30:00-04:00 2021-04-14T16:30:00-04:00 Off Campus Location Engineering Education Research Lecture / Discussion Dr. Laura Hirshfield
CCMB / DCMB Weekly Seminar (April 14, 2021 4:00pm) https://events.umich.edu/event/83595 83595-21436485@events.umich.edu Event Begins: Wednesday, April 14, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:
My lab's research involves the development and application of systems biology approaches—combining computation, machine learning, quantitative modeling, and experiments—to study the immune system in health and disease. Recent technological and computational advances allow comprehensive interrogation of multiple modalities (e.g., proteins, mRNAs, immune receptor sequences) in single cell resolution in the human population. Here I will highlight our work in the analysis human and single cell variations along the axes of early immune development, vaccination, and COVID-19. If time permits, I will also discuss the integration of tissue imaging, machine learning, and multiscale dynamical modeling of immune cell interactions to investigate the homeostatic regulation of autoreactive T cells.

* * *

Biography: Dr. Tsang is a senior investigator in the NIH Intramural Research Program and leads a laboratory focusing on systems and quantitative immunology at the National Institute of Allergy and Infectious Diseases (NIAID). He also co-directs the Trans-NIH Center for Human Immunology (CHI) and leads its research program in systems human immunology. Dr. Tsang trained in computer engineering and computer science at the University of Waterloo and received his Ph.D. in biophysics from Harvard University. Dr. Tsang has worked as a software engineer and pursued systems biology research in both academia and industry including Rosetta Inpharmatics, Caprion Proteomics, MIT, and Merck Research Laboratories. Dr. Tsang has won several awards for his research, including NIAID Merit Awards for the development of a data reuse and crowdsourcing platform OMiCC and for leading a system biology study of human immune variability and influenza vaccination, which was selected as a top NIAID Research Advances of 2014. He currently serves as the founding chief editor of systems immunology for Frontiers in Immunology. He has served as a scientific advisor for a number of programs and organizations including ImmPort (the clinical and molecular data repository for NIAID), the Committee on Precision Medicine for the World Allergy Organization, the NIAID Modeling Immunity for Biodefense Program, the Allen Institute, the Immuno-Epidemiology Program at the National Cancer Institute, and the Human Vaccines Project.

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Wed, 07 Apr 2021 08:59:05 -0400 2021-04-14T16:00:00-04:00 2021-04-14T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual
IPD Online Trade Show: Self Sufficient and In Control (April 15, 2021 12:00am) https://events.umich.edu/event/83777 83777-21506944@events.umich.edu Event Begins: Thursday, April 15, 2021 12:00am
Location: Off Campus Location
Organized By: Tauber Institute for Global Operations

Online IPD Trade Show
Cast your vote April 14-20! Struggling to adjust to major life disruptions caused by the pandemic, many people are longing to gain an increased sense of self-sufficiency and life control. U-M students in this semester's Integrated Product Development (IPD) created brand new products that help fill this need.

Take part in this nationally renowned course by reviewing the products developed by 6 teams of students from the University of Michigan's STAMPS School of Art & Design, Ross School of Business, College of Engineering, and School of Information.

Catch the competitive buzz!

View the products online. Then cast your vote!

VOTE ONLINE:
https://myumi.ch/MEwyz

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Exhibition Wed, 01 Dec 2021 16:35:21 -0500 2021-04-15T00:00:00-04:00 2021-04-15T23:00:00-04:00 Off Campus Location Tauber Institute for Global Operations Exhibition IPD ONLINE TRADE SHOW
Become a UROP Summer Research Mentor (April 15, 2021 7:00am) https://events.umich.edu/event/82262 82262-21060635@events.umich.edu Event Begins: Thursday, April 15, 2021 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Submit a Research Project: https://lsa.umich.edu/urop/research-mentors.html

UROP Research Mentors are faculty and post-doc researchers who provide undergraduate student researchers an opportunity to engage in research activities that help them learn about the pursuit of knowledge within an academic discipline. This early exposure to research fosters a valuable academic experience for students. Through this collaboration, students gain research skills and mentorship that lead to academic retention, a more positive undergraduate experience and paths to graduate school.

Summer research mentors will collaborate with UROP students participating in 10-week full time Summer Fellowships.

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Other Wed, 21 Apr 2021 14:43:33 -0400 2021-04-15T07:00:00-04:00 2021-04-15T23:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Other Become a UROP Mentor
BME 500 Seminar: Kelly J. Cross (April 15, 2021 4:00pm) https://events.umich.edu/event/81394 81394-20889824@events.umich.edu Event Begins: Thursday, April 15, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Join us for a virtual seminar series on topics related to race and science, technology, engineering and math (STEM) education. https://happenings.wustl.edu/event/an_honest_conversation_about_inequity_in_engineering#.YG9vT-hKhPY

Details:
DATE: Thursday, April 15, 2021
TIME: 4:00-5:00 PM
ZOOM LINK TO REGISTER: https://wustl.zoom.us/webinar/register/WN_NvH4qVTSRx2uSXbdW-eXNA

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Lecture / Discussion Wed, 14 Apr 2021 14:13:34 -0400 2021-04-15T16:00:00-04:00 2021-04-15T17:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Coded Bias "At the Movies" Panel Discussion (April 15, 2021 4:00pm) https://events.umich.edu/event/83580 83580-21430624@events.umich.edu Event Begins: Thursday, April 15, 2021 4:00pm
Location: Off Campus Location
Organized By: Information Assurance

Join a panel of U-M experts over Zoom for an "At the Movies" style discussion of the film Coded Bias. The panelists will exchange views on the challenges presented by technologies that reflect the systemic biases in American society. Panelists include:
- Nazanin Andalibi, assistant professor of information, School of Information; assistant professor of Digital Studies Institute, College of Literature, Science, and the Arts (LSA)
- Mingyan Liu, Peter and Evelyn Fuss Chair of Electrical and Computer Engineering, Electrical Engineering and Computer Science (EECS)
- Nicholson Price, professor of law, Law School
- Grace Trinidad (moderator), Ethics, Legal, and Social Implications (ELSI) postdoctoral fellow, School of Public Health

AVAILABLE PRIOR TO THE DISCUSSION
To be better informed prior to the Coded Bias panel discussion, be sure to take time to watch a free screening of the film between April 8 and April 14. More information is available at https://safecomputing.umich.edu/events/dissonance/coded-bias-free-movie-viewing

Access to Coded Bias and the panel discussion are brought to you by the Dissonance Event Series, ITS Information Assurance, the U-M School of Information, and the Law School’s Privacy and Technology Law Association.

Add the panel discussion to your Google Calendar: https://calendar.google.com/calendar/u/0/r/eventedit/copy/MWZjMnFtNmw0MzN2MDk0cmRyaHQ4b3VpMTggdW1pY2guZWR1X2ZkczI0Z2V2cGE0MnY5NTc2bG5wZTJjbWxrQGc

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Lecture / Discussion Fri, 09 Apr 2021 14:43:13 -0400 2021-04-15T16:00:00-04:00 2021-04-15T17:00:00-04:00 Off Campus Location Information Assurance Lecture / Discussion Dissonance Event Series: Panel Discussion on the film Coded Bias
IPD Online Trade Show: Self Sufficient and In Control (April 16, 2021 12:00am) https://events.umich.edu/event/83777 83777-21506945@events.umich.edu Event Begins: Friday, April 16, 2021 12:00am
Location: Off Campus Location
Organized By: Tauber Institute for Global Operations

Online IPD Trade Show
Cast your vote April 14-20! Struggling to adjust to major life disruptions caused by the pandemic, many people are longing to gain an increased sense of self-sufficiency and life control. U-M students in this semester's Integrated Product Development (IPD) created brand new products that help fill this need.

Take part in this nationally renowned course by reviewing the products developed by 6 teams of students from the University of Michigan's STAMPS School of Art & Design, Ross School of Business, College of Engineering, and School of Information.

Catch the competitive buzz!

View the products online. Then cast your vote!

VOTE ONLINE:
https://myumi.ch/MEwyz

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Exhibition Wed, 01 Dec 2021 16:35:21 -0500 2021-04-16T00:00:00-04:00 2021-04-16T23:00:00-04:00 Off Campus Location Tauber Institute for Global Operations Exhibition IPD ONLINE TRADE SHOW
Become a UROP Summer Research Mentor (April 16, 2021 7:00am) https://events.umich.edu/event/82262 82262-21060636@events.umich.edu Event Begins: Friday, April 16, 2021 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Submit a Research Project: https://lsa.umich.edu/urop/research-mentors.html

UROP Research Mentors are faculty and post-doc researchers who provide undergraduate student researchers an opportunity to engage in research activities that help them learn about the pursuit of knowledge within an academic discipline. This early exposure to research fosters a valuable academic experience for students. Through this collaboration, students gain research skills and mentorship that lead to academic retention, a more positive undergraduate experience and paths to graduate school.

Summer research mentors will collaborate with UROP students participating in 10-week full time Summer Fellowships.

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Other Wed, 21 Apr 2021 14:43:33 -0400 2021-04-16T07:00:00-04:00 2021-04-16T23:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Other Become a UROP Mentor
BME Master's Defense: Fatimah Alkaabi (April 16, 2021 12:00pm) https://events.umich.edu/event/83558 83558-21424731@events.umich.edu Event Begins: Friday, April 16, 2021 12:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

The central auditory system consists of the brain nuclei that transmit peripheral auditory nerve input to the auditory cortex for hearing perception. Damage to the auditory end organ, the cochlea, can result in hearing loss that drives the central auditory system to disarray causing disorders such as hyperacusis and tinnitus. These disorders can negatively affect patients’ quality of life. Tinnitus sufferers generally describe their tinnitus as a narrowband of sound that occurs in quiet, while hyperacusis sufferers express an exaggerated perception of sound level or intensity. These two disorders are often grouped together because tinnitus sufferers tend to report symptoms of hyperacusis and vice versa. However, hyperacusis and tinnitus do not always co-occur, suggesting that they have different neural origins. To study these conditions, researchers have induced cochlear damage in animal models, followed by behavioral and electrophysiological assessments. However, no study has adequately distinguished hyperacusis from tinnitus in individual animals. In this thesis, I detail the development of a novel hyperacusis and tinnitus assessment paradigm for individual animals using the pinna reflex combined with auditory brainstem responses (ABR). In the first chapter, I detail several enhancements to a computer system that ensures accurate sound presentation concurrently with capture of pinna reflex video data, as well as streamlines the subsequent data analysis. In the second chapter, the ABR, an evoked potential reflecting the summed electrical activity of cells in the auditory brainstem pathway, was assessed. Several studies suggest that ABR-wave characteristics might provide evidence of hyperacusis. ABRs were evoked using conventional and novel sound stimuli. They were then examined to look for possible indications of hyperacusis in noise overexposed guinea pigs. The present findings are discussed with several suggestions for future hyperacusis assessments.



Date: Friday, April 16, 2021

Time: 12:00 PM

Zoom: https://umich.zoom.us/j/91698183229

Chair: Dr. Susan Shore

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Lecture / Discussion Mon, 05 Apr 2021 23:04:39 -0400 2021-04-16T12:00:00-04:00 2021-04-16T13:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Great Lakes Security Conference / CTF (April 16, 2021 12:00pm) https://events.umich.edu/event/83749 83749-21485474@events.umich.edu Event Begins: Friday, April 16, 2021 12:00pm
Location: Off Campus Location
Organized By: WolvSec

The Great Lakes Security Conference is brought to you by student ran organizations from Michigan Technological University and The University of Michigan. We are proud to be hosting a fully virtual event that includes talks from various industry professionals, alongside a CTF that you can sign up for and compete in for various prizes.

Speakers include; Cindy Cohn the Executive Director of the Electronic Frontier Foundation, Jeff Bar Vice President & Chief Evangelist at Amazon Web Services, Steve Booth Chief Security Officer of FireEye, our Professor Daniel Genkin, and about a dozen more speakers. You can find out more at https://glsc.tech/

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Conference / Symposium Tue, 13 Apr 2021 15:20:32 -0400 2021-04-16T12:00:00-04:00 2021-04-16T19:00:00-04:00 Off Campus Location WolvSec Conference / Symposium Event Logo
Harnessing the Digital Revolution to Build the Water Sector of the Future with Newsha K. Ajami (April 16, 2021 2:00pm) https://events.umich.edu/event/83618 83618-21438456@events.umich.edu Event Begins: Friday, April 16, 2021 2:00pm
Location: Off Campus Location
Organized By: Civil and Environmental Engineering

The water sector is at a crossroad. Facing the challenges of ageing infrastructure and a growing population, the sector has to replace and rebuild its existing network, which had enabled our nation’s social and economic growth during the past century. In the meantime, climate change and its impacts on the water cycle have demonstrated the shortcomings and vulnerabilities of our current infrastructure network and its inability to handle extreme and intensified climatic patterns such as floods, droughts, hurricane and wildfires. The need to revisit and reimagine our current infrastructure model is clear, but the path not as much.

The sector can continue to invest in its current infrastructure model or alternatively embrace decentralized, distributed, and nature-based water solutions. These new infrastructure options hold the promise to increase system flexibility and resilience under climate change while taking the pressure off our existing aging infrastructure networks. However, implementation of these solutions still suffers from the rigidity and complexity of our current water use systems, and the fragmented and in some cases outdated governance structures and business model that overlay them.

There is a need to build a diverse financing portfolio and novel governance tools that harnesses our evolving digital economy and could support the sector’s shifting paradigm as it transitions from centralized model to a 21st century hybrid model, encompassing both centralized and decentralized solutions. In this seminar, Ajami will discuss some of these challenges and provide some thoughts on how the sector can take advantage of this once in a century opportunity and aim to transform itself while embracing new solutions and business models.

Newsha K. Ajami directs the Urban Water Policy Program at Stanford Woods Institute for the Environment. A leading expert in sustainable water resource management, water policy, and the water-energy-food nexus, she studies the human and policy dimensions of urban water and hydrologic systems. Dr. Ajami served as a gubernatorial appointee to the Bay Area Regional Water Quality Control Board for two terms and is currently a mayoral appointee to the San Francisco Public Utilities Commission. She has published many highly cited peer-reviewed articles, and contributed opinion pieces to the New York Times and the Sacramento Bee. Dr. Ajami received her Ph.D. in civil and environmental engineering from the UC, Irvine, an M.S. in hydrology and water resources from the University of Arizona.

Panelists:

Jon Allan, Academic and Research Program Officer Sr., School for Environment and Sustainability, University of Michigan
Eric Letsinger, CEO, Quantified Ventures
Sanjiv Sinha, Senior Vice President, Environmental Consulting & Technology, Inc. (ECT)

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Livestream / Virtual Fri, 09 Apr 2021 13:27:47 -0400 2021-04-16T14:00:00-04:00 2021-04-16T15:00:00-04:00 Off Campus Location Civil and Environmental Engineering Livestream / Virtual Newsha K. Ajami
Winter 2021 Colloquia Series (April 16, 2021 4:00pm) https://events.umich.edu/event/80817 80817-20793347@events.umich.edu Event Begins: Friday, April 16, 2021 4:00pm
Location: Off Campus Location
Organized By: Nuclear Engineering and Radiological Sciences

Zoom login info is below. Non-U-M Community members can email brownsu@umich.edu to request access.

Jan 22: Jake DeWitte, Oklo Inc.
Oklo Microreactor Development

Jan 29: Rui Qiu, Tsinghua University
Multi-scale Radiation Dosimetry with Computational Human Phantoms

Feb 5: Kate Turner, MIT Media Lab
Towards Intersectional Equity in Complex Sociotechnical Systems

Feb 12: Raluca Scarlat, UC Berkeley
The Relevance of Chemical Studies in Molten Fluoride Salts to Development of Advanced Nuclear Reactors

Feb 19: Tomi Akindele, Lawrence Livermore National Laboratory
Reactor Antineutrinos for Nuclear Safeguards

Feb 26: Scott Baalrud, U-M Nuclear Engineering and Radiological Sciences
Is This Even a Plasma? Physics of Strongly Coupled Plasmas

Mar 5: Ronnie Shepard, Lawrence Livermore National Laboratory
Exploring Energy Transport at Stellar Inner Conditions Utilizing Ultrashort Pulse Lasers

Mar 12: Peter Yarsky, Nuclear Regulatory Commission
A Nuclear Engineer’s Approach to Modeling the Novel Coronavirus Pandemic

Mar 19: Dawn Montgomery, Clemson University
An Integrative Approach to Environmental Radiation Protection: Plant Influence on Radionuclide Transport, Plant Uptake, and Non-Human Biota Dosimetry

Mar 26: Dr. Heather J. Maclean Chichester, Idaho National Laboratory
Challenges and Solutions for Examining Irradiated Fuels and Materials in a Harsh Environment

Apr 2: Lara Pierpoint, Actuate
Electric Utility Innovation

Apr 9: Denia Djokić, Fastest Path to Zero Initiative
Reflections on Risk and Trust: Commemorating Fukushima and Chernobyl During Covid-19

Apr 16: John Jackson, Idaho National Laboratory
DOE Microreactor Program: Technology to Enable Microreactor Development, Deployment and Commercialization

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Workshop / Seminar Mon, 12 Apr 2021 10:45:38 -0400 2021-04-16T16:00:00-04:00 2021-04-16T17:00:00-04:00 Off Campus Location Nuclear Engineering and Radiological Sciences Workshop / Seminar NERS Colloquia
IPD Online Trade Show: Self Sufficient and In Control (April 17, 2021 12:00am) https://events.umich.edu/event/83777 83777-21506946@events.umich.edu Event Begins: Saturday, April 17, 2021 12:00am
Location: Off Campus Location
Organized By: Tauber Institute for Global Operations

Online IPD Trade Show
Cast your vote April 14-20! Struggling to adjust to major life disruptions caused by the pandemic, many people are longing to gain an increased sense of self-sufficiency and life control. U-M students in this semester's Integrated Product Development (IPD) created brand new products that help fill this need.

Take part in this nationally renowned course by reviewing the products developed by 6 teams of students from the University of Michigan's STAMPS School of Art & Design, Ross School of Business, College of Engineering, and School of Information.

Catch the competitive buzz!

View the products online. Then cast your vote!

VOTE ONLINE:
https://myumi.ch/MEwyz

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Exhibition Wed, 01 Dec 2021 16:35:21 -0500 2021-04-17T00:00:00-04:00 2021-04-17T23:00:00-04:00 Off Campus Location Tauber Institute for Global Operations Exhibition IPD ONLINE TRADE SHOW
Become a UROP Summer Research Mentor (April 17, 2021 7:00am) https://events.umich.edu/event/82262 82262-21060637@events.umich.edu Event Begins: Saturday, April 17, 2021 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Submit a Research Project: https://lsa.umich.edu/urop/research-mentors.html

UROP Research Mentors are faculty and post-doc researchers who provide undergraduate student researchers an opportunity to engage in research activities that help them learn about the pursuit of knowledge within an academic discipline. This early exposure to research fosters a valuable academic experience for students. Through this collaboration, students gain research skills and mentorship that lead to academic retention, a more positive undergraduate experience and paths to graduate school.

Summer research mentors will collaborate with UROP students participating in 10-week full time Summer Fellowships.

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Other Wed, 21 Apr 2021 14:43:33 -0400 2021-04-17T07:00:00-04:00 2021-04-17T23:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Other Become a UROP Mentor
Great Lakes Security Conference / CTF (April 17, 2021 12:00pm) https://events.umich.edu/event/83749 83749-21485475@events.umich.edu Event Begins: Saturday, April 17, 2021 12:00pm
Location: Off Campus Location
Organized By: WolvSec

The Great Lakes Security Conference is brought to you by student ran organizations from Michigan Technological University and The University of Michigan. We are proud to be hosting a fully virtual event that includes talks from various industry professionals, alongside a CTF that you can sign up for and compete in for various prizes.

Speakers include; Cindy Cohn the Executive Director of the Electronic Frontier Foundation, Jeff Bar Vice President & Chief Evangelist at Amazon Web Services, Steve Booth Chief Security Officer of FireEye, our Professor Daniel Genkin, and about a dozen more speakers. You can find out more at https://glsc.tech/

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Conference / Symposium Tue, 13 Apr 2021 15:20:32 -0400 2021-04-17T12:00:00-04:00 2021-04-17T19:00:00-04:00 Off Campus Location WolvSec Conference / Symposium Event Logo
IPD Online Trade Show: Self Sufficient and In Control (April 18, 2021 12:00am) https://events.umich.edu/event/83777 83777-21506947@events.umich.edu Event Begins: Sunday, April 18, 2021 12:00am
Location: Off Campus Location
Organized By: Tauber Institute for Global Operations

Online IPD Trade Show
Cast your vote April 14-20! Struggling to adjust to major life disruptions caused by the pandemic, many people are longing to gain an increased sense of self-sufficiency and life control. U-M students in this semester's Integrated Product Development (IPD) created brand new products that help fill this need.

Take part in this nationally renowned course by reviewing the products developed by 6 teams of students from the University of Michigan's STAMPS School of Art & Design, Ross School of Business, College of Engineering, and School of Information.

Catch the competitive buzz!

View the products online. Then cast your vote!

VOTE ONLINE:
https://myumi.ch/MEwyz

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Exhibition Wed, 01 Dec 2021 16:35:21 -0500 2021-04-18T00:00:00-04:00 2021-04-18T23:00:00-04:00 Off Campus Location Tauber Institute for Global Operations Exhibition IPD ONLINE TRADE SHOW
Become a UROP Summer Research Mentor (April 18, 2021 7:00am) https://events.umich.edu/event/82262 82262-21060638@events.umich.edu Event Begins: Sunday, April 18, 2021 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Submit a Research Project: https://lsa.umich.edu/urop/research-mentors.html

UROP Research Mentors are faculty and post-doc researchers who provide undergraduate student researchers an opportunity to engage in research activities that help them learn about the pursuit of knowledge within an academic discipline. This early exposure to research fosters a valuable academic experience for students. Through this collaboration, students gain research skills and mentorship that lead to academic retention, a more positive undergraduate experience and paths to graduate school.

Summer research mentors will collaborate with UROP students participating in 10-week full time Summer Fellowships.

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Other Wed, 21 Apr 2021 14:43:33 -0400 2021-04-18T07:00:00-04:00 2021-04-18T23:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Other Become a UROP Mentor
Great Lakes Security Conference / CTF (April 18, 2021 12:00pm) https://events.umich.edu/event/83749 83749-21485476@events.umich.edu Event Begins: Sunday, April 18, 2021 12:00pm
Location: Off Campus Location
Organized By: WolvSec

The Great Lakes Security Conference is brought to you by student ran organizations from Michigan Technological University and The University of Michigan. We are proud to be hosting a fully virtual event that includes talks from various industry professionals, alongside a CTF that you can sign up for and compete in for various prizes.

Speakers include; Cindy Cohn the Executive Director of the Electronic Frontier Foundation, Jeff Bar Vice President & Chief Evangelist at Amazon Web Services, Steve Booth Chief Security Officer of FireEye, our Professor Daniel Genkin, and about a dozen more speakers. You can find out more at https://glsc.tech/

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Conference / Symposium Tue, 13 Apr 2021 15:20:32 -0400 2021-04-18T12:00:00-04:00 2021-04-18T19:00:00-04:00 Off Campus Location WolvSec Conference / Symposium Event Logo
IPD Online Trade Show: Self Sufficient and In Control (April 19, 2021 12:00am) https://events.umich.edu/event/83777 83777-21506948@events.umich.edu Event Begins: Monday, April 19, 2021 12:00am
Location: Off Campus Location
Organized By: Tauber Institute for Global Operations

Online IPD Trade Show
Cast your vote April 14-20! Struggling to adjust to major life disruptions caused by the pandemic, many people are longing to gain an increased sense of self-sufficiency and life control. U-M students in this semester's Integrated Product Development (IPD) created brand new products that help fill this need.

Take part in this nationally renowned course by reviewing the products developed by 6 teams of students from the University of Michigan's STAMPS School of Art & Design, Ross School of Business, College of Engineering, and School of Information.

Catch the competitive buzz!

View the products online. Then cast your vote!

VOTE ONLINE:
https://myumi.ch/MEwyz

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Exhibition Wed, 01 Dec 2021 16:35:21 -0500 2021-04-19T00:00:00-04:00 2021-04-19T23:00:00-04:00 Off Campus Location Tauber Institute for Global Operations Exhibition IPD ONLINE TRADE SHOW
Become a UROP Summer Research Mentor (April 19, 2021 7:00am) https://events.umich.edu/event/82262 82262-21060639@events.umich.edu Event Begins: Monday, April 19, 2021 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Submit a Research Project: https://lsa.umich.edu/urop/research-mentors.html

UROP Research Mentors are faculty and post-doc researchers who provide undergraduate student researchers an opportunity to engage in research activities that help them learn about the pursuit of knowledge within an academic discipline. This early exposure to research fosters a valuable academic experience for students. Through this collaboration, students gain research skills and mentorship that lead to academic retention, a more positive undergraduate experience and paths to graduate school.

Summer research mentors will collaborate with UROP students participating in 10-week full time Summer Fellowships.

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Other Wed, 21 Apr 2021 14:43:33 -0400 2021-04-19T07:00:00-04:00 2021-04-19T23:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Other Become a UROP Mentor
MIDAS Seminar Series Presents: Ben Wellington, Quantitative Analyst, Two Sigma (April 19, 2021 4:00pm) https://events.umich.edu/event/81088 81088-20846549@events.umich.edu Event Begins: Monday, April 19, 2021 4:00pm
Location: Off Campus Location
Organized By: Michigan Institute for Data Science

Ben Wellington is a Quantitative Analyst at Two Sigma and the creator of I Quant NY, a data science and policy blog that focuses on insights drawn from New York City’s public data, and advocates for the expansion and improvement of that data. His data science has influenced local government policy including changes in NYC street infrastructure, the way New Yorkers pay for cabs and the design of NYC subway vending machines. Ben is a contributor to the New Yorker, and a visiting assistant professor in the City & Regional Planning program at the Pratt Institute in Brooklyn where he teaches statistics using urban open data and holds a Ph.D. in Computer Science from New York University.

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Presentation Fri, 22 Jan 2021 11:05:47 -0500 2021-04-19T16:00:00-04:00 2021-04-19T17:00:00-04:00 Off Campus Location Michigan Institute for Data Science Presentation Ben Wellington
IPD Online Trade Show: Self Sufficient and In Control (April 20, 2021 12:00am) https://events.umich.edu/event/83777 83777-21506949@events.umich.edu Event Begins: Tuesday, April 20, 2021 12:00am
Location: Off Campus Location
Organized By: Tauber Institute for Global Operations

Online IPD Trade Show
Cast your vote April 14-20! Struggling to adjust to major life disruptions caused by the pandemic, many people are longing to gain an increased sense of self-sufficiency and life control. U-M students in this semester's Integrated Product Development (IPD) created brand new products that help fill this need.

Take part in this nationally renowned course by reviewing the products developed by 6 teams of students from the University of Michigan's STAMPS School of Art & Design, Ross School of Business, College of Engineering, and School of Information.

Catch the competitive buzz!

View the products online. Then cast your vote!

VOTE ONLINE:
https://myumi.ch/MEwyz

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Exhibition Wed, 01 Dec 2021 16:35:21 -0500 2021-04-20T00:00:00-04:00 2021-04-20T23:00:00-04:00 Off Campus Location Tauber Institute for Global Operations Exhibition IPD ONLINE TRADE SHOW
Become a UROP Summer Research Mentor (April 20, 2021 7:00am) https://events.umich.edu/event/82262 82262-21060640@events.umich.edu Event Begins: Tuesday, April 20, 2021 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Submit a Research Project: https://lsa.umich.edu/urop/research-mentors.html

UROP Research Mentors are faculty and post-doc researchers who provide undergraduate student researchers an opportunity to engage in research activities that help them learn about the pursuit of knowledge within an academic discipline. This early exposure to research fosters a valuable academic experience for students. Through this collaboration, students gain research skills and mentorship that lead to academic retention, a more positive undergraduate experience and paths to graduate school.

Summer research mentors will collaborate with UROP students participating in 10-week full time Summer Fellowships.

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Other Wed, 21 Apr 2021 14:43:33 -0400 2021-04-20T07:00:00-04:00 2021-04-20T23:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Other Become a UROP Mentor
Become a UROP Summer Research Mentor (April 21, 2021 7:00am) https://events.umich.edu/event/82262 82262-21060641@events.umich.edu Event Begins: Wednesday, April 21, 2021 7:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Submit a Research Project: https://lsa.umich.edu/urop/research-mentors.html

UROP Research Mentors are faculty and post-doc researchers who provide undergraduate student researchers an opportunity to engage in research activities that help them learn about the pursuit of knowledge within an academic discipline. This early exposure to research fosters a valuable academic experience for students. Through this collaboration, students gain research skills and mentorship that lead to academic retention, a more positive undergraduate experience and paths to graduate school.

Summer research mentors will collaborate with UROP students participating in 10-week full time Summer Fellowships.

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Other Wed, 21 Apr 2021 14:43:33 -0400 2021-04-21T07:00:00-04:00 2021-04-21T23:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Other Become a UROP Mentor
Master's Defense: Annie Taylor (April 21, 2021 10:30am) https://events.umich.edu/event/83750 83750-21485477@events.umich.edu Event Begins: Wednesday, April 21, 2021 10:30am
Location: Off Campus Location
Organized By: Biomedical Engineering

Dopamine regulates motor performance and learning. Current models suggest that dopamine signals reward-prediction errors and/or movement vigor. These functions have been assessed predominantly using simple behavioral tasks. The role of dopamine in dexterous skill, however, is unknown. This question is important to understanding motor disorders such as Parkinson's Disease. Here we describe an experimental model to interrogate the role of dopamine release during learning and performance of dexterous skill. Fluorescent sensors dLight1.1 and GCaMP are used to monitor dopamine and calcium activity in the striatum and substantia nigra pars compacta (SNc) in rats performing skilled reaching tasks. Preliminary experiments have successfully recorded reward-associated signals in both striatum and SNc. Adaptations to the recording setup to facilitate long-term recording in larger rodents are described. These results demonstrate the viability of fiber photometry for measuring dopamine-related activity during skilled reaching tasks.



Date: Wednesday April 21, 2021

Time: 10:30 AM

Zoom: https://umich.zoom.us/j/96449273959

Chair: Dr. Dan Leventhal

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Lecture / Discussion Tue, 13 Apr 2021 15:34:29 -0400 2021-04-21T10:30:00-04:00 2021-04-21T11:30:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Student-Made Video Games Virtual Showcase (April 21, 2021 6:45pm) https://events.umich.edu/event/83460 83460-21381639@events.umich.edu Event Begins: Wednesday, April 21, 2021 6:45pm
Location: Off Campus Location
Organized By: EECS 494: Introduction to Game Development

Experience 20+ new student-made video games at the EECS 494 + EMU Games Virtual Showcase! Interact with the developers, learn more about Michigan and EMU's game development programs, and vote for your favorite games!

Visit https://494showcase.com at 7pm EST on 12/08 to participate!

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Exhibition Wed, 31 Mar 2021 00:45:31 -0400 2021-04-21T18:45:00-04:00 2021-04-21T22:00:00-04:00 Off Campus Location EECS 494: Introduction to Game Development Exhibition EECS 494 Virtual Showcase
UROP Spring Research Symposium (April 22, 2021 9:00am) https://events.umich.edu/event/80918 80918-20822893@events.umich.edu Event Begins: Thursday, April 22, 2021 9:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Join us via Zoom all day, or throughout the day on April 22.

The Undergraduate Research Opportunity Program’s Annual Research Symposium is the culminating event for all students participating in UROP Programs. The event celebrates the partnerships created between students and research mentors, and serves as a conference where students present their research project and learn about the research their fellow UROP students have worked on throughout the program.

Spring 2021 Symposium Agenda
Keynote (9:00am - 9:50am)
Session 1 Presentations (10:00am - 10:50am)
Session 2 Presentations (11:00am - 11:50am)
Outstanding Mentor Award Ceremony (12:00pm - 1:00pm)
Session 3 Presentations (1:00pm - 1:50pm)
Session 4 Presentations (2:00pm - 2:50pm)
Session 5 Presentations (3:00pm - 3:50pm)
Session 6 Presentations (4:00pm - 4:50pm)

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Conference / Symposium Tue, 06 Apr 2021 08:37:57 -0400 2021-04-22T09:00:00-04:00 2021-04-22T17:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Conference / Symposium UROP Research Reimagined
Special Joint Seminar between DCMB, Mathematics, MIDAS, and Smale Institute (April 22, 2021 1:00pm) https://events.umich.edu/event/83615 83615-21491327@events.umich.edu Event Begins: Thursday, April 22, 2021 1:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

The quest to understand consciousness, once the purview of philosophers and theologians, is now actively pursued by scientists of many stripes. This talk looks at consciousness from the perspective of theoretical computer science. It formalizes the Global Workspace Theory (GWT) originated by cognitive neuroscientist Bernard Baars and further developed by him, Stanislas Dehaene, and others. Our major contribution lies in the precise formal definition of a Conscious Turing Machine (CTM), also called a Conscious AI. We define the CTM in the spirit of Alan Turing’s simple yet powerful definition of a computer, the Turing Machine (TM). We are not looking for a complex model of the brain nor of cognition but for a simple model of (the admittedly complex concept of) consciousness. After formally defining CTM, we give a formal definition of consciousness in CTM. We then suggest why the CTM has the feeling of consciousness. The reasonableness of the definitions and explanations can be judged by how well they agree with commonly accepted intuitive concepts of human consciousness, the range of related concepts that the model explains easily and naturally, and the extent of its agreement with scientific evidence.

https://umich.zoom.us/j/95135773568

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Livestream / Virtual Wed, 14 Apr 2021 10:17:45 -0400 2021-04-22T13:00:00-04:00 2021-04-22T14:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual
Implantable Neural Interfaces for Direct Control of Hand Prostheses (April 27, 2021 10:00am) https://events.umich.edu/event/83793 83793-21530358@events.umich.edu Event Begins: Tuesday, April 27, 2021 10:00am
Location: Off Campus Location
Organized By: Michigan Robotics

State of the art robotic hands can mimic many functions of the human hand. These devices are a capable of actuating individual finger and multi-joint movements while providing adequate gripping force for daily activities. However, for patients with spinal cord injuries or amputations, there are few options to control these functions seamlessly or intuitively. A common barrier to restoring hand function to both populations is a lack of high-fidelity control signals. Non-invasive electrophysiological techniques record global summations of activity and lack the spatial or temporal resolution to extract or “decode” precise movement commands. The ability to decode finger movements from the motor system would allow patients to directly control hand functions and provide intuitive and scalable prosthetic solutions. This thesis investigates the capabilities of implantable devices to provide finger-specific commands for prosthetic hands. We adapt existing reasoning algorithms to two different sensing technologies.

The first is intracortical electrode arrays implanted into primary motor cortex of two non-human primates. Both subjects controlled a virtual hand with a regression algorithm that decoded their brain activity into finger kinematics. Performance was evaluated with a single degree of freedom target matching task. A state-of-the-art re-calibration approach improved performance, measured as bit rate, by an average of 33.1%. Notably, decoding performance was not dependent on subjects moving their intact hands. In future research, this approach can improve grasp precision for patients with spinal cord injuries.

The second sensing technology is intramuscular electrodes implanted into residual muscles and Regenerative Peripheral Nerve Interfaces of two patients with transradial amputations. Both participants used a high-speed pattern recognition system to switch between 10 individual finger and wrist postures in a virtual environment with an average success rate of 94.7% and a trial latency of 255 ms. When the set was reduced to five grasp postures, average metrics improved to 100% success and 135 ms latency. These results are a significant improvement over state-of-the-art systems that use surface electromyography as inputs. Furthermore, grasp performance remained reliable across arm positions and both participants used this controller to complete a functional assessment with robotic prostheses.
For a more dexterous solution, we combined the high-speed pattern recognition system with a regression algorithm that enabled simultaneous position control of both the index finger and middle-ring-small finger group. Both patients used this system to complete a virtual two degree of freedom target matching task with throughputs of 1.79 and 1.15 bits per second each. The controllers in this study used only four and five differentiated inputs, which can feasibly be processed with portable or implantable hardware.

These results demonstrate that implantable systems can provide patients with fluid and precise control of hand prostheses, eliminating the need to use movement substitutions and triggers to cycle through grip modes. However, clinically translatable implantable electronics need to be developed to realize the potential of these sensing and reasoning approaches. Further advancement of this technology will likely increase the utility and demand of robotic prostheses.

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Livestream / Virtual Mon, 19 Apr 2021 13:55:31 -0400 2021-04-27T10:00:00-04:00 2021-04-27T12:00:00-04:00 Off Campus Location Michigan Robotics Livestream / Virtual prosthetic hand stacks block
Interpretable and Realtime Predictions of Social Interactions for Autonomous Vehicles (April 29, 2021 3:00pm) https://events.umich.edu/event/83792 83792-21530357@events.umich.edu Event Begins: Thursday, April 29, 2021 3:00pm
Location: Off Campus Location
Organized By: Michigan Robotics

Autonomous vehicles present an opportunity to transform transportation. The benefits range from increased access to mobility and time freed from driving, to greater safety due to automation. These robots are powered by the coordination of various systems to perceive the world and effect motion control. Crucially, the autonomous vehicle operates in an open environment alongside fellow road users with whom it will interact regularly. Predictions of fellow road users' intents and future motion guide these interactions and specify a large part of the autonomous vehicle's behavior. Spurred by advances in deep learning, recent prediction methods have increasingly begun to consider how interactions affect future motion in ever more varied environments. The corresponding gains in accuracy translate to more anticipatory and less reactive autonomous vehicle behavior. One drawback is an increase in complexity, which can lead to less interpretable predictions and behavior. Achieving realtime performance and handling missing data caused by adverse sensing conditions present additional challenges.

To support autonomous vehicle behavior that is transparent and predictable, this thesis develops interpretable prediction methods. Model-based approaches provide the vehicle for building interpretable predictions, and novel inference procedures are developed to generate the predictions in realtime. Adopting a probabilistic framework enables natural handling of missing data and affords the flexibility to model interactions in varied environments beyond those described by existing interpretable methods. Experiments on real highway traffic and urban data demonstrate the developed methods' effectiveness.

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Livestream / Virtual Mon, 19 Apr 2021 10:09:07 -0400 2021-04-29T15:00:00-04:00 2021-04-29T17:00:00-04:00 Off Campus Location Michigan Robotics Livestream / Virtual autonomous car merging
Master's Defense: Ivo Cerda (April 30, 2021 10:00am) https://events.umich.edu/event/83915 83915-21612995@events.umich.edu Event Begins: Friday, April 30, 2021 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

Co-registering, chronic, and naturalistic assessments of the electrophysiological and behavioral features of the murine stress response can teach us how stress-behaviors are mechanistically driven by electrophysiological activity in neural circuits, how those relationships change over the course of the multi-week developing response to chronic ongoing stress, and how these changes ultimately contribute to the pathogenesis and progression of major depressive disorder and other psychiatric conditions. However, the long duration and multiplexed nature of the murine stress response have long been barriers to achieving such understandings. To address the need for technology that better captures the time progression of the murine stress response, we engineered the first-ever chronic recording system capable of gathering both behavioral and electrophysiological data in a naturalistic environment for freely-moving mice. Building from previous unpublished work at our lab, we first developed 16 units of a novel photointerrupter-based, Arduino-controlled digital phenotyping system capable of simultaneously recording 50+ behavioral metrics at a sub-second resolution continuously for weeks at a time. Subsequently, with the goal of assisting the concurrent exploration of brain mechanisms and behavior, we engineered a scaffold and cabling structure to support an ultra low-resistance commutator that allows chronic, multi-region brain electrophysiological recordings and integrated it into our digital behavioral phenotyping system. Our novel co-recording system is now fully operational and, along with allowing chronic electrophysiological recordings, supports measures of eating, drinking, food and sugary drink preference (a measure of anhedonia), locomotor activity, sleep, and actigraphy, all the while using 24/7 video tracking to allow detailed classification of behaviors at sub-second resolution. The system is also compatible with standard assessments in the field, including daily weight and fur checks. To demonstrate the duration of its co-recording capabilities, we implanted a cohort of mice with electrodes in three brain regions involved in the murine stress response – olfactory bulb, dorsal hippocampus, and medial prefrontal cortex – and recorded for five weeks. This is the first system to ever produce highly dense behavioral and electrophysiological data simultaneously and continuously over such a period of time.


Details:
DATE: Friday, April 30, 2021
TIME: 10:00 am - 12:00 pm
LOCATION: Zoom https://umich.zoom.us/j/93571968494)
Chair Committee: Brendon Watson, Tim Bruns, Cindy Chestek

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Lecture / Discussion Thu, 29 Apr 2021 20:12:17 -0400 2021-04-30T10:00:00-04:00 2021-04-30T12:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Engineering Disaster-Resilient Systems in an Uncertain Future with Jack Baker (April 30, 2021 1:00pm) https://events.umich.edu/event/83856 83856-21555870@events.umich.edu Event Begins: Friday, April 30, 2021 1:00pm
Location: Off Campus Location
Organized By: Civil and Environmental Engineering

There are several radical changes underway in the design of the built environment to resist disasters. First, the traditional practice of designing only for occupant safety is being questioned. Societal stakeholders are increasingly also demanding that our facilities and infrastructure recover rapidly and for reasonable costs. Achieving these demands requires a deeper understanding of the recovery process, and of the interaction between the built environment and human systems. Second, climate change, rapid urbanization, and other drivers mean that our past experience with disasters is no longer a direct guide for what we will experience in the future. Achieving future performance targets thus requires new predictive techniques and tools to design for performance objectives. In this seminar, Dr. Baker will discuss these changes, and describe some research underway to advance our ability to create a disaster-resilient built environment.

Jack Baker’s work focuses on the development and use of probabilistic and statistical tools for managing risk due to extreme loads on the built environment. He studies risk to spatially distributed systems, characterization of earthquake ground motions, and probabilistic risk assessments for a number of types of structures. Professor Baker joined Stanford in 2006 from the Swiss Federal Institute of Technology (ETH Zurich), where he was a visiting researcher in the Department of Structural Engineering. He has degrees in Structural Engineering (Stanford, M.S. 2002, Ph.D. 2005), Statistics (Stanford, M.S. 2004) and Mathematics/Physics (Whitman College, B.A. 2000). His awards include the Shah Family Innovation Prize from the Earthquake Engineering Research Institute, the CAREER Award from the National Science Foundation, the Early Achievement Research Award from the International Association for Structural Safety and Reliability, the Walter L. Huber Prize from ASCE, the Helmut Krawinkler Award from the Structural Engineers Association of Northern California, and the Eugene L. Grant Award for excellence in teaching from Stanford.

Panelists:

Sherif El-Tawil, Antoine E. Naaman Collegiate Professor of Civil and Environmental Engineering, University of Michigan
Chris Poland, Consulting Engineer

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Livestream / Virtual Thu, 22 Apr 2021 13:48:30 -0400 2021-04-30T13:00:00-04:00 2021-04-30T14:00:00-04:00 Off Campus Location Civil and Environmental Engineering Livestream / Virtual Jack Baker
BME Commencement 2021 (May 1, 2021 3:30pm) https://events.umich.edu/event/83890 83890-21595415@events.umich.edu Event Begins: Saturday, May 1, 2021 3:30pm
Location: Off Campus Location
Organized By: Biomedical Engineering

PLEASE MAKE SURE TO RSVP WITH THE LINK!

BME COMMENCEMENT CEREMONY
SATURDAY, MAY 1, 2021 | 3:30 PM EDT


COMMENCEMENT CEREMONY
ZOOM @ (3:30 PM)

AFTER PARTY
Spatial Chat @ (~4:30 PM)
(AFTER THE CEREMONY)

PROGRAM
Welcome & Introduction | Lonnie Shea Ph.D.
Program Chair Remarks | Rachael Schmedlen, Ph.D., Jan Stegemann, Ph.D., & Tim Bruns, Ph.D.
Program Coordinator Remarks | Rachel Patterson & Maria Steele
Alumni Welcome and Congratulations | Scott Merz, Richard Youngblood, & Xiaotian Tan
Student Addresses | Dipra Debnath, Ivo Woldarsky, & Katy Norman
Announcing the Graduates | Melissa Wrobel Ph.D., Brendon Baker, Ph.D., James Weiland, Ph.D., & Tim Bruns, Ph.D.
Confirmation of Degrees | Lonnie Shea, Ph.D.
Congratulations and Closing | Lonnie Shea, Ph.D.
Virtual socializing & After Party | Come congratulate and socialize with your fellow graduates, families, professors, and friends following the BME Commencement Ceremony.

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Ceremony / Service Tue, 27 Apr 2021 15:09:45 -0400 2021-05-01T15:30:00-04:00 Off Campus Location Biomedical Engineering Ceremony / Service BME Logo
PhD Defense: Jonas Schollenberger (May 4, 2021 3:00pm) https://events.umich.edu/event/83855 83855-21555868@events.umich.edu Event Begins: Tuesday, May 4, 2021 3:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Cerebrovascular occlusive disease (CVOD) is a major risk factor for ischemic stroke and is characterized by the presence of stenosis in the arteries supplying the brain. The cerebral vasculature has an innate ability to compensate for flow reductions, caused by the presence of CVOD, through a network of collateral pathways in the circle of Willis (CoW). However, flow compensation is highly patient-specific and dependent on the cerebral vasculature anatomy, availability of collateral pathways, degree of stenosis and, the condition of the cerebral microcirculation and its autoregulatory response. Unfortunately, clinically available imaging tools only provide limited information on flow compensation and the underlying cerebral hemodynamics. Given the complexity of the cerebral vasculature, better tools are necessary to characterize cerebral hemodynamics and guide the risk assessment of ischemic stroke.



Image-based computational fluid dynamics (CFD) provides a powerful tool for non-invasively analyzing cerebral hemodynamics with high spatial and temporal resolutions. However, CFD modeling of cerebral hemodynamics is challenging due to the need for patient-specific data to calibrate outflow boundary conditions in the brain. In this thesis, we explore a novel strategy to quantitatively characterize cerebral hemodynamics using CFD in combination with tissue perfusion from arterial spin labeling (ASL) MRI.



Firstly, we quantified territorial perfusion in the cerebral circulation through implementing and optimizing a vessel-selective arterial spin labeling (VS-ASL) sequence. VS-ASL is generally limited by its low labeling efficiency causing poor signal-to-noise ratio. We investigated the effects of off‐resonance, pulsatility, and vessel movement, and evaluated methods to maximize labeling efficiency and overall image quality. We found that an off-resonance calibration scan in combination with cardiac-triggering significantly improved labeling efficiency and image quality. Vessel movement during the MRI protocol occurred in the majority of study subjects and needs to be accounted for to maximize labeling efficiency.



Secondly, we developed a strategy to calibrate patient-specific CFD models of cerebral blood flow. The calibration consisted of estimating the total inflow to the CoW from PC-MRI and the flow splits in the CoW from non-selective ASL perfusion images. The outflow boundary conditions were iteratively tuned to match the estimated flow splits, and the ASL-calibrated CFD model was then validated against territorial perfusion maps from VS-ASL by calculating the blood supply to each cerebral territory using Lagrangian particle tracking (LPT). We found an overall good match in a small group of subjects; particularly, the flow compensation between hemispheres was captured well by the calibrated CFD models.



Thirdly, we investigated the impact of two outflow boundary condition strategies, an ASL-based and allometric-based calibration, on cerebral hemodynamics. The ASL-based calibrated CFD analysis captured the flow compensation between hemispheres as measured with VS-ASL and lead to an approximately symmetrical flow distribution in the CoW. In contrast, the allometric-based calibrated CFD analysis was unable to capture the collateral flow compensation, which resulted in large differences in flow between hemispheres.



Finally, the clinical feasibility and capabilities of our proposed CFD analysis was demonstrated in two CVOD patients. The CFD analysis showed significant differences in cerebral hemodynamics between the patients despite similar degrees of stenosis severity, highlighting the importance of a patient-specific assessment. Comparison of pre-operative and post-operative hemodynamics in one patient resulted in only minor changes following revascularization despite severe carotid stenosis. We demonstrated that our CFD analysis can provide detailed and quantitative information about hemodynamic impact of carotid stenosis and collateral flow compensation in the circle of Willis.


Date: Tuesday, May 4, 2021

Time: 3:00 PM

Zoom: https://umich.zoom.us/j/93059726229 (Zoom link requires prior registration)

Co-Chairs: Dr. C. Alberto Figueroa and Dr. Luis Hernandez-Garcia

For Assistance or Questions
um-bme@umich.edu

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Lecture / Discussion Thu, 22 Apr 2021 13:33:46 -0400 2021-05-04T15:00:00-04:00 2021-05-04T16:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Computing our way out of a pandemic: modeling in the face of COVID-19 (May 6, 2021 9:00am) https://events.umich.edu/event/83689 83689-21454211@events.umich.edu Event Begins: Thursday, May 6, 2021 9:00am
Location: Off Campus Location
Organized By: Michigan Institute for Computational Discovery and Engineering

The COVID-19 pandemic has produced massive amounts of information that require an accurate analysis to predict outcomes and design solutions rapidly. It also has required experts from many different backgrounds to rally around in the quest for rapid responses in the race to save lives.

Many of the most prominent of these researchers are from Michigan, and a significant number of them are computational scientists who addressed questions such as: What measures should be taken to minimize contagion? Is it safe to ride a bus? How are supply and demand chains being affected?

This virtual symposium will bring together researchers from the State of Michigan to share their past and future insights into the pandemic.

This is a free Zoom event, open to the general public. Please register to attend: https://umich.zoom.us/webinar/register/WN_47ZZyf_ZTFqwef3kd8icsg

Check out the event website for more event details + agenda: https://micde.umich.edu/modeling-covid-19-symposium-2021/

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Conference / Symposium Thu, 15 Apr 2021 16:49:02 -0400 2021-05-06T09:00:00-04:00 2021-05-06T16:30:00-04:00 Off Campus Location Michigan Institute for Computational Discovery and Engineering Conference / Symposium COVID-19 Modeling Symposium, May 6, 2021
PhD Defense: Elissa Welle (May 7, 2021 10:00am) https://events.umich.edu/event/83883 83883-21587612@events.umich.edu Event Begins: Friday, May 7, 2021 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

Neural interfaces create a connection between neural structures in the body and external electronic devices. Brain-machine interfaces and bioelectric medicine therapies rely on the seamless integration of neural interfaces with the brain, nerves, or spinal cord. However, conventional neural interfaces cannot meet the demands of high channel count, signal fidelity, and signal longevity that these applications require.



In this thesis we characterized the damage resulting from conventional Utah arrays after multiple years of implantation in the cortex of a non-human primate. The neuron density around the electrode shanks was compared to the neuron density of nearby healthy tissue, finding a 73% loss in density around the electrodes. The explanted arrays were imaged and characterized for forms of electrode surface inconsistency. Coating cracks, tip breakage, and parylene cracks were the most common inconsistency. A significantly higher number of tip breakage and coating crack occurrences were found on the edges of the arrays as compared to the middle. In this work, we made clear the need for a minimally damaging alternative to the Utah electrode array.



Neural interfaces composed of carbon fiber electrodes, with a diameter of 6.8 microns, could enable a more seamless integration with the body. Previous work resulted in an array of individuated carbon fiber electrodes that could record reliably high signal-to-noise ratio neural signals from the brain for several months. However, the carbon fiber arrays were limited by only 30% of the electrodes recording neural signals, despite inducing very minimal inflammation. Additionally, it was relatively unknown if carbon fibers would make suitable long-term peripheral neural interfaces. Here, we illustrate the potential of carbon fiber electrodes to meet the needs of a variety of neural applications.



First, we optimized state-of-the-art carbon fiber electrodes to reliably record single unit electrophysiology from the brain. By analyzing the previous manufacturing process, the cause of the low recording yield of the carbon fiber arrays was identified as the consistency of the electrode tip. A novel laser cutting technique was developed to produce a consistent carbon fiber tip geometry, resulting in a near tripling of recording yield of high amplitude chronic neural signals. The longevity of the carbon fiber arrays was also addressed. The conventional polymer coating was compared against platinum iridium coating and an oxygen plasma treatment, both of which outperformed the polymer coating. In this work, we customized carbon fiber electrodes for reliable, long-term neural recording.



Secondly, we translated the carbon fiber technology from the brain to the periphery in an architecture appropriate for chronic implantation. The insertion of carbon fibers into the stiffer structures in the periphery is enabled by sharpening the carbon fibers. The sharpening process combines a butane flame to sharpen the fibers with a water bath to protect the base of the array. Sharpened carbon fibers recorded electrophysiology from the rat vagus nerve and feline dorsal root ganglia, both structures being important targets for bioelectric medicine therapies. The durability of carbon fibers was also displayed when partially embedded carbon fibers in medical-grade silicone withstood thousands of repeated bends without fracture. This work showed that carbon fibers have the electrical and structural properties necessary for chronic application.



Overall, this work highlights the vast potential of carbon fiber electrodes. Through this thesis, future brain-machine interfaces and bioelectric medicine therapies may utilize sub-cellular electrodes such as carbon fibers in medical applications.



Date: Friday, May 7, 2021

Time: 10:00 AM

Zoom: https://umich.zoom.us/j/95839545566 (Zoom link requires prior registration)

Chair: Dr. Cynthia Chestek

For Assistance or Questions
um-bme@umich.edu

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Lecture / Discussion Mon, 26 Apr 2021 17:03:39 -0400 2021-05-07T10:00:00-04:00 2021-05-07T11:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Space Symposium 2021 (May 7, 2021 10:30am) https://events.umich.edu/event/83575 83575-21430601@events.umich.edu Event Begins: Friday, May 7, 2021 10:30am
Location: Off Campus Location
Organized By: Students for the Exploration and Development of Space

The 2021 virtual Space Symposium is a two-day event planned by the Students for the Exploration and Development of Space at U-M (SEDS@UM) with the goal of demonstrating the space-related projects students and faculty at the University of Michigan are working on. SEDS has invited professors, research labs, industry professionals, and student project teams to talk about their experiences working on space exploration related fields. The primary goal of this event is to showcase and bring attention to the work being done by University of Michigan students and labs on space related projects. Learn more by visiting the event website at https://seds.engin.umich.edu/space-symposium.

Register through Eventbrite and add yourself to the event Slack workspace to receive the Zoom link for the event. We hope to see you there!

If you have any questions, contact umss-2021@umich.edu.

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Conference / Symposium Wed, 07 Apr 2021 17:35:38 -0400 2021-05-07T10:30:00-04:00 2021-05-07T17:30:00-04:00 Off Campus Location Students for the Exploration and Development of Space Conference / Symposium Space Symposium 2021 Poster
Space Symposium 2021 (May 8, 2021 10:30am) https://events.umich.edu/event/83575 83575-21430602@events.umich.edu Event Begins: Saturday, May 8, 2021 10:30am
Location: Off Campus Location
Organized By: Students for the Exploration and Development of Space

The 2021 virtual Space Symposium is a two-day event planned by the Students for the Exploration and Development of Space at U-M (SEDS@UM) with the goal of demonstrating the space-related projects students and faculty at the University of Michigan are working on. SEDS has invited professors, research labs, industry professionals, and student project teams to talk about their experiences working on space exploration related fields. The primary goal of this event is to showcase and bring attention to the work being done by University of Michigan students and labs on space related projects. Learn more by visiting the event website at https://seds.engin.umich.edu/space-symposium.

Register through Eventbrite and add yourself to the event Slack workspace to receive the Zoom link for the event. We hope to see you there!

If you have any questions, contact umss-2021@umich.edu.

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Conference / Symposium Wed, 07 Apr 2021 17:35:38 -0400 2021-05-08T10:30:00-04:00 2021-05-08T17:30:00-04:00 Off Campus Location Students for the Exploration and Development of Space Conference / Symposium Space Symposium 2021 Poster
2021 BME Symposium (May 10, 2021 12:00pm) https://events.umich.edu/event/82858 82858-21203302@events.umich.edu Event Begins: Monday, May 10, 2021 12:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

To register please see:
https://myumi.ch/r8GzZ

The 2021 BME symposium will showcase our work in the areas of Imaging, Neural Engineering, Regenerative Medicine, and Precision Health. The event will take place over two days in the afternoons of Monday, May 10, 12:00 PM - 5:00 PM, and Tuesday, May 11, 12:00 PM - 5:00 PM. Each afternoon will include faculty talks, mini student dissertations, a panel discussion, and student poster sessions.

The goal of this event is to bring together faculty and students affiliated with BME from all parts of campus as a step toward building the BME community and celebrating accomplishments through difficult times while having an eye toward the future.

Please sign up and join us!

2021 U-M BME Symposium



May 10, 2021: 12:00 PM - 5:00 PM


Imaging at UM

May 10, 2021 - 12:00pm - 1:30pm
Location: Virtual/Zoom
Livestream Available (Visible After Registration)

Moderator: Doug Noll
12:00 - 12:15 - Zhongming Liu, “Preclinical MRI of brain-gut interactions”
12:15 - 12:30 - Nicole Seiberlich, “Translating Quantitative MRI to the Clinic”
12:30 - 12:45 - Yannis Paulus, “Multimodal Photoacoustic Microscopy, OCT, and Fluorescence Molecular and Cellular Imaging of the Retina”
12:45 - 1:05 - Student Dissertations
1:05 - 1:30 - Panel Discussion - “The Future of Imaging Research at Michigan” - Vikas Gulani, Jeff Fessler, Cheri Deng, Zhen Xu, Xueding Wang


Neural Engineering at UM

May 10, 2021 - 2:00pm - 3:30pm
Location: Virtual/Zoom
Livestream Available (Visible After Registration)

Moderator: Jim Weiland
2:00 - 2:15 - Kamran Diba, TBD
2:15 - 2:30 - Scott Lempka, TBD
2:30 - 2:45 - Deanna Gates, TBD
2:45 - 3:05 - Student Dissertations
3:05 - 3.30 - Panel Discussion - “The Science Fiction Future of Neural Engineering” - Cindy Chestek, Parag Patil, Tim Bruns, Bill Stacey


Poster Session: Imaging & Neural Engineering

May 10, 2021 - 4:00pm - 5:00pm
Location: Virtual/Spatial Chat

This poster session will give BME students a chance to present and discuss their research in the areas of Imaging and Neural Engineering.


May 11, 2021: 12:00 PM - 5:00 PM


Regenerative Medicine at UM

May 11, 2021 - 12:00pm - 1:30pm
Location: Virtual/Zoom
Livestream Available (Visible After Registration)

Moderator: Lonnie Shea
12:00 - 12:15 - Carlos Aguilar, ”Understanding & Re-Writing Stem Cell Programs to Live Forever.”
12:15 - 12:30 - Idse Heemskerk, “Predicting cell fate from signaling history in human pluripotent stem cells”
12:30 - 12:45 - Ariella Shikanov, TBD
12:45 - 1:05 - Student Dissertations
1:05 - 1:30 - Panel Discussion - "Grand Challenges in Regenerative Medicine" - Dave Kohn


Precision Health at UM

May 11, 2021 - 2:00pm - 3:30pm
Location: Virtual/Zoom
Livestream Available (Visible After Registration)

Moderator: TBD
2:00 - 2:15 - Sriram Chandrasekharan, TBD
2:15 - 2: 30 - James Moon, TBD
2:30 - 2:45 - Deepak Nagrath, TBD
2:45 - 3:05 - Student Dissertations
3:05 - 3:30 - Panel Discussion - "Hope or Hype for Treating Diseases" - James Moon, Sriram Chandrasekharan, Deepak Nagrath



Poster Session: Regenerative Medicine & Precision Health


May 11, 2021 - 4:00pm - 5:00pm
Location: Virtual/Spatial Chat


This poster session will give BME students a chance to present and discuss their research in the areas of Regenerative Medicine and Precision Health.

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Conference / Symposium Thu, 22 Apr 2021 13:38:37 -0400 2021-05-10T12:00:00-04:00 2021-05-10T17:00:00-04:00 Off Campus Location Biomedical Engineering Conference / Symposium BME Logo
2021 BME Symposium (May 11, 2021 12:00pm) https://events.umich.edu/event/82858 82858-21555869@events.umich.edu Event Begins: Tuesday, May 11, 2021 12:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

To register please see:
https://myumi.ch/r8GzZ

The 2021 BME symposium will showcase our work in the areas of Imaging, Neural Engineering, Regenerative Medicine, and Precision Health. The event will take place over two days in the afternoons of Monday, May 10, 12:00 PM - 5:00 PM, and Tuesday, May 11, 12:00 PM - 5:00 PM. Each afternoon will include faculty talks, mini student dissertations, a panel discussion, and student poster sessions.

The goal of this event is to bring together faculty and students affiliated with BME from all parts of campus as a step toward building the BME community and celebrating accomplishments through difficult times while having an eye toward the future.

Please sign up and join us!

2021 U-M BME Symposium



May 10, 2021: 12:00 PM - 5:00 PM


Imaging at UM

May 10, 2021 - 12:00pm - 1:30pm
Location: Virtual/Zoom
Livestream Available (Visible After Registration)

Moderator: Doug Noll
12:00 - 12:15 - Zhongming Liu, “Preclinical MRI of brain-gut interactions”
12:15 - 12:30 - Nicole Seiberlich, “Translating Quantitative MRI to the Clinic”
12:30 - 12:45 - Yannis Paulus, “Multimodal Photoacoustic Microscopy, OCT, and Fluorescence Molecular and Cellular Imaging of the Retina”
12:45 - 1:05 - Student Dissertations
1:05 - 1:30 - Panel Discussion - “The Future of Imaging Research at Michigan” - Vikas Gulani, Jeff Fessler, Cheri Deng, Zhen Xu, Xueding Wang


Neural Engineering at UM

May 10, 2021 - 2:00pm - 3:30pm
Location: Virtual/Zoom
Livestream Available (Visible After Registration)

Moderator: Jim Weiland
2:00 - 2:15 - Kamran Diba, TBD
2:15 - 2:30 - Scott Lempka, TBD
2:30 - 2:45 - Deanna Gates, TBD
2:45 - 3:05 - Student Dissertations
3:05 - 3.30 - Panel Discussion - “The Science Fiction Future of Neural Engineering” - Cindy Chestek, Parag Patil, Tim Bruns, Bill Stacey


Poster Session: Imaging & Neural Engineering

May 10, 2021 - 4:00pm - 5:00pm
Location: Virtual/Spatial Chat

This poster session will give BME students a chance to present and discuss their research in the areas of Imaging and Neural Engineering.


May 11, 2021: 12:00 PM - 5:00 PM


Regenerative Medicine at UM

May 11, 2021 - 12:00pm - 1:30pm
Location: Virtual/Zoom
Livestream Available (Visible After Registration)

Moderator: Lonnie Shea
12:00 - 12:15 - Carlos Aguilar, ”Understanding & Re-Writing Stem Cell Programs to Live Forever.”
12:15 - 12:30 - Idse Heemskerk, “Predicting cell fate from signaling history in human pluripotent stem cells”
12:30 - 12:45 - Ariella Shikanov, TBD
12:45 - 1:05 - Student Dissertations
1:05 - 1:30 - Panel Discussion - "Grand Challenges in Regenerative Medicine" - Dave Kohn


Precision Health at UM

May 11, 2021 - 2:00pm - 3:30pm
Location: Virtual/Zoom
Livestream Available (Visible After Registration)

Moderator: TBD
2:00 - 2:15 - Sriram Chandrasekharan, TBD
2:15 - 2: 30 - James Moon, TBD
2:30 - 2:45 - Deepak Nagrath, TBD
2:45 - 3:05 - Student Dissertations
3:05 - 3:30 - Panel Discussion - "Hope or Hype for Treating Diseases" - James Moon, Sriram Chandrasekharan, Deepak Nagrath



Poster Session: Regenerative Medicine & Precision Health


May 11, 2021 - 4:00pm - 5:00pm
Location: Virtual/Spatial Chat


This poster session will give BME students a chance to present and discuss their research in the areas of Regenerative Medicine and Precision Health.

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Conference / Symposium Thu, 22 Apr 2021 13:38:37 -0400 2021-05-11T12:00:00-04:00 2021-05-11T17:00:00-04:00 Off Campus Location Biomedical Engineering Conference / Symposium BME Logo
Connecting Education Innovation to Activism (May 12, 2021 12:00pm) https://events.umich.edu/event/83807 83807-21538170@events.umich.edu Event Begins: Wednesday, May 12, 2021 12:00pm
Location: Off Campus Location
Organized By: RISE (Research. Innovation. Scholarship. Education.)

R.I.S.E., the Center for Academic Innovation, and the Center for Research on Learning & Teaching (CRLT) invite you to join a Virtual Talking Circle (VTC) to discuss unique connections between education innovation & activism.

This collaboration across the University will serve as a first step in building a community interested in designing and promoting education innovation to improve society.

Anyone interested in education innovation and/or social justice and activism is invited!  We want to learn who is already doing this important work and identify potential collaborations across the University.

Please join us on Wednesday, May 12, 2021 from 12:00 - 1:00 PM

Register via Eventbrite

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Workshop / Seminar Tue, 20 Apr 2021 06:37:52 -0400 2021-05-12T12:00:00-04:00 2021-05-12T13:00:00-04:00 Off Campus Location RISE (Research. Innovation. Scholarship. Education.) Workshop / Seminar RISE Virtual Talking Circle
Lagranian Control at Large and Local Scales in Mixed Autonomy Traffic Flows (May 13, 2021 1:00pm) https://events.umich.edu/event/83812 83812-21538223@events.umich.edu Event Begins: Thursday, May 13, 2021 1:00pm
Location: Off Campus Location
Organized By: Center for Connected and Automated Transportation

The CCAT Distinguished Lecture Series returns this May with Professor Alexandre Bayen, the Liao-Cho Professor of Engineering at UC Berkeley! This talk investigates Lagrangian (mobile) control of traffic flow at local scale (vehicular level), and how self-driving vehicles will change traffic flow patterns. Professor Bayen describes approaches based on deep, reinforcement learning presented in the context of enabling mixed-autonomy mobility. This lecture also explores the gradual and complex integration of automated vehicles into the existing traffic system. Attendees will learn the potential impact of a small fraction of automated vehicles on low-level traffic flow dynamics, using novel techniques in model-free, deep reinforcement learning, in which the automated vehicles act as mobile (Lagrangian) controllers to traffic flow.

Illustrative examples will be presented in the context of a new, open-source computational platform called FLOW, which integrates state-of-the-art microsimulation tools with deep-RL libraries on AWS EC2. Interesting behavior of mixed autonomy traffic will be revealed in the context of emergent behavior of traffic: https://flow-project.github.io/

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Livestream / Virtual Tue, 20 Apr 2021 10:42:19 -0400 2021-05-13T13:00:00-04:00 2021-05-13T14:00:00-04:00 Off Campus Location Center for Connected and Automated Transportation Livestream / Virtual Decorative Image
Precision Health Webinar (May 25, 2021 1:00pm) https://events.umich.edu/event/83924 83924-21617135@events.umich.edu Event Begins: Tuesday, May 25, 2021 1:00pm
Location: Off Campus Location
Organized By: Precision Health

Precision Health at the University of Michigan (U-M) invites you to engage with two outstanding Scholars who have been funded by Precision Health to develop their research.
Arun Subramaniyan, BE, MS (graduate student, College of Engineering): “Hardware-accelerated systems for next-generation sequencing analysis”

Alyse Krausz, BS, MS (graduate student research assistant, Biomedical Engineering): “A Point-of-Care Microfluidic System for Traumatic Brain Injury Diagnosis and Prognosis”

You'll hear more about their work and how they used Precision Health resources in these innovative projects.

**Please register to attend. We will send a link to the virtual presentation a few days in advance. We hope you'll join us!**

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Livestream / Virtual Tue, 04 May 2021 13:45:53 -0400 2021-05-25T13:00:00-04:00 2021-05-25T14:00:00-04:00 Off Campus Location Precision Health Livestream / Virtual May 2021 PH Webinar
Real-time Human Workload Estimation and Its Application in Adaptive Haptic Shared Control (May 25, 2021 1:30pm) https://events.umich.edu/event/84054 84054-21619770@events.umich.edu Event Begins: Tuesday, May 25, 2021 1:30pm
Location: Off Campus Location
Organized By: Michigan Robotics

Automated vehicles (AVs) are promising to have the potential to reduce driving-related injuries and deaths. However, autonomous driving technology is currently limited in its scope and reliability, giving rise to the semi-autonomous driving model, where the autonomy and the human share the control of the vehicle. Workload, despite being an important human factor, has not yet been considered when designing adaptive shared control. Recently, researchers have started to apply machine learning techniques to classify mental workload into different levels. However, most of these studies have adopted either a single-model-single-feature approach or a single-model-all-features approach. However different machine learning models are suitable for different features, how to leverage different models for different features is critical.

To address these shortcomings and research gaps, the goals of this dissertation were to (1) examine whether and to what extent haptic shared control performance can be improved by incorporating operators' workload; (2) develop a computational model for workload estimation, and the model should be able to leverage different machine learning models that work best for different features; and (3) investigate the generalizability of the workload estimation model. To address these research goals, this dissertation was composed of four research phases with two pilot studies and four human subject experiments.

(1) Collaborating with Yifan Weng, Dr. Tulga Ersal, and Prof. Jeffrey Stein from the Department of Mechanical Engineering at the University of Michigan, we developed a teleoperated dual-task shared control simulation platform where the human shared control of a ground vehicle with autonomy while performing a surveillance task simultaneously. In addition, we developed a real-time eye-tracking system based on Tobii Pro Glasses 2 to measure the human gaze points in a world frame and pupil sizes.

(2) We proposed a workload-adaptive haptic shared control scheme together with our collaborators. We conducted two human subject experiments during this phase. The results indicated that the proposed workload-adaptive haptic shared control scheme can reduce human workload, increase human trust in the system, increase driving performance, and reduce human effort without sacrificing surveillance task performance.

(3) We proposed a Bayesian inference model for workload estimation that can leverage the different machine learning models that work best for different features. Specifically, we used support-vector machines (SVMs) for pupil size change, the Hidden Markov Model (HMM) for gaze trajectory, SVMs for fixation feature, and Gaussian Mixture Models (GMMs) for fixation trajectory. The empirical results indicated that our proposed model achieved a 0.82 F1 score for workload imposed by varying surveillance task urgency.

(4) We investigated the generalizability of our proposed Bayesian inference model for workload estimation by conducting two human subject experiments with 24 participants and using different factors to impose human workload, i.e., obstacle headway and driving speed. The results indicated that our proposed model achieved a 0.70 F1 score for the workload imposed by obstacle avoidance and the personalized version of our proposed model can distinguish the workload imposed by different driving speeds under high surveillance task urgency.

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Lecture / Discussion Mon, 17 May 2021 10:55:54 -0400 2021-05-25T13:30:00-04:00 2021-05-25T15:00:00-04:00 Off Campus Location Michigan Robotics Lecture / Discussion simulating driving while multitasking
PhD Defense: Edward Peter Washabaugh IV (May 27, 2021 10:00am) https://events.umich.edu/event/84050 84050-21619709@events.umich.edu Event Begins: Thursday, May 27, 2021 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

Injuries to the neuromusculoskeletal systems often result in muscle weakness, abnormal coordination strategies, and gait impairments. Functional resistance training during walking—where a patient walks while a device increases loading on the leg—is an emerging approach to combat these symptoms. While simple passive devices (i.e., ankle weights and resistance bands) can be applied for this training, rehabilitation robots have more potential upside because they can be controlled to treat multiple gait abnormalities and can be monitored by clinicians. However, the cost of conventional robotic devices limits their use in the clinical or home setting. Hence, in this dissertation, we designed, developed, and tested passive and semi-passive wearable exoskeleton devices as a low-cost solution for providing controllable/configurable functional resistance training during walking.


We developed and tested two passive exoskeleton devices for providing resistance to walking and tested their effects on able-bodied participants and stroke survivors. First, we created a patented device that used a passive magnetic brake to provide a viscous (i.e., velocity-dependent) resistance to the knee. The resistive properties of the device could be placed under computer control (i.e., made semi-passive) to control resistance in real-time. Next, we created a passive exoskeleton that provided an elastic (i.e., position-dependent) resistance. While not controllable, this device was highly configurable. Meaning it could be used to provide resistance to joint flexion, extension, or to both (i.e., bidirectionally). Human subjects testing with these devices indicated they increased lower-extremity joint moments, powers, and muscle activation during training. Training also resulted in significant aftereffects—a potential indicator of therapeutic effectiveness—once the resistance was removed. A separate experiment indicated that individuals often kinematically slack (i.e., reduce joint excursions to minimize effort) when resistance is added to the limb. We also found that providing visual feedback of joint angles during training significantly increased muscle activation and kinematic aftereffects (i.e., reduced slacking).


With passive devices, the type of passive element used largely dictates the muscle groups, types of muscle contraction, joint actions, and the phases of gait when a device is able to apply resistance. To examine this issue, we compared the training effects of viscous and elastic devices that provided bidirectional resistance to the knee during gait. Additionally, we compared training with viscous resistances at the hip and knee joints. While the resistance type and targeted joint altered moments, powers, and muscle activation patterns, these methods did not differ in their ability to produce aftereffects, alter neural excitability, or induce fatigue in the leg muscles. While this may indicate that the resistance type does not have a large effect on functional resistance training during walking, it is possible that an extended training with these devices could produce a different result.


Lastly, we used musculoskeletal modeling in OpenSim to directly compare several strategies that have been used to provide functional resistance training to gait in the clinic or laboratory setting. We found that devices differed in their ability to alter gait parameters during walking. Hence, these findings could help clinicians when selecting a resistive strategy for their patients, or engineers when designing new devices or control schemes.



Date: Thursday, May 27, 2021

Time: 10:00 AM

Zoom: https://umich.zoom.us/meeting/register/tJIufumrrDgtHd3z5Jg3Y_BG4ZC70OPrjTjk (Zoom link requires prior registration)

Chair: Dr. Chandramouli Krishnan

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Lecture / Discussion Fri, 14 May 2021 13:49:26 -0400 2021-05-27T10:00:00-04:00 2021-05-27T11:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Advanced Energy Technologies (June 2, 2021 11:00am) https://events.umich.edu/event/84087 84087-21619938@events.umich.edu Event Begins: Wednesday, June 2, 2021 11:00am
Location: Off Campus Location
Organized By: Nuclear Engineering and Radiological Sciences

This all-star panel of energy experts will dive into the legal, socio-political, and environmental considerations for small modular nuclear reactors. In addition to offering a technical overview, the 90-minute panel will discuss clean energy standards, zero emission credits, licensing, regulations, and safety issues.

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Workshop / Seminar Thu, 20 May 2021 10:30:33 -0400 2021-06-02T11:00:00-04:00 2021-06-02T12:30:00-04:00 Off Campus Location Nuclear Engineering and Radiological Sciences Workshop / Seminar Event Flyer
PhD Defense: William Y. Wang (June 4, 2021 12:30pm) https://events.umich.edu/event/84102 84102-21620248@events.umich.edu Event Begins: Friday, June 4, 2021 12:30pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Mechanoreciprocity in cell migration is an emerging concept describing the dynamic, bi-directional interactions between migrating cells and the surrounding extracellular matrix (ECM) they negotiate. Migrating cells not only sense and adapt to biochemical and biophysical ECM cues, but also, exert forces, deposit matrix, and secrete chemokines, matrix metalloproteinases, and matrix crosslinking enzymes that dynamically alter the same ECM properties known to regulate cell migration. Due to limitations in standard cell migration assays, how matrix properties influence cell migration and in turn, how cells influence matrix properties, has previously been studied as separate processes. However, observations from development, wound healing, and a variety of disease processes highlight the interdependency and iterative relationship between cell migration and ECM. An improved understanding of the underlying mechanisms that orchestrate the coevolution of migrating cells and ECM will aid in tissue engineering and regenerative medicine efforts to guide repair fibroblasts to regenerate wound beds, direct collective endothelial cell migration to vascularize ischemic or engineered tissue grafts and confine otherwise metastatic cancer cells to the primary tumor. Thus, the focus of this dissertation is to design biomimetic microsystems that afford investigation of cell migration mechanoreciprocity with a focus on fibroblasts, endothelial cells, and cancer cells.



First, this thesis investigated how single mesenchymal cells (fibroblasts and cancer cells) migrate in fibrous stromal tissue settings, such as in trans-stromal cancer cell migration during metastasis. To model fibrous stromal tissue, 3D fiber networks were electrospun over microfabricated wells to define ECM mechanics. Independently tuning alignment and stiffness of these matrices resulted in two phenotypically distinct cell migration modes. In contrast to stiff matrices where cells migrated continuously in a traditional mesenchymal fashion, cells in deformable matrices stretched matrix fibers to store elastic energy; subsequent adhesion failure triggered sudden matrix recoil and rapid cell translocation (termed slingshot migration). Across a variety of cell types, traction force measurements revealed a relationship between cell contractility and the matrix stiffness where slingshot migration mode occurred optimally.



Next, this thesis describes how microenvironmental cues influence collective endothelial cell migration during sprouting angiogenesis towards the design of pro-angiogenic biomaterials. This work employed a multiplexed angiogenesis-on-a-chip platform to assess the chemokine-directed 3D invasion of endothelial cells from a lumenized parent vessel into user-defined ECM. By tuning soluble and physical cues of the ECM, this work identified how 1) functional angiogenesis requires microenvironmental cues that balance cell invasion speed and proliferation; 2) dynamic interactions between sprout stalk cells and ECM regulates neovessel lumenization; and 3) imbuing microporosity within synthetic hydrogels can enhance endothelial cell invasion and angiogenic sprout lumenization.



Lastly, this thesis investigated how fibrous matrix cues activate quiescent vessel-lining endothelial cells into invasive tip cells in the context of fibrosis. Composite hydrogels (electrospun fiber segments suspended within 3D ECM) were integrated with the angiogenesis-on-a-chip platform. These studies establish that heightened matrix fiber density destabilizes cell-cell adherens junctions, reduces endothelium barrier function, and promotes the invasion of endothelial tip cells. Performing transcriptomic and secretomic analyses on fiber-induced tip endothelial cells revealed that fibrous ECM cues promote a fibrosis propagating phenotype.



Overall, the work presented in this dissertation integrates tunable biomaterials with microfabricated devices to investigate cell migration mechanoreciprocity of single mesenchymal cell migration, the collective migration of endothelial cells during angiogenesis, and endothelial-mesenchymal transition of quiescent endothelial cells into a fibrosis propagating cell phenotype.



Date: Friday, June 4, 2021

Time: 12:30 PM

Zoom: https://umich.zoom.us/meeting/register/tJcsf-uhpj4vGtyM7x-td2VV39BzqmF_zoob (Zoom link requires prior registration)

Chair: Dr. Brendon Baker

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Lecture / Discussion Mon, 24 May 2021 14:17:02 -0400 2021-06-04T12:30:00-04:00 2021-06-04T13:30:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Getting Engaged in Campus Education Innovation Activities (June 9, 2021 12:00pm) https://events.umich.edu/event/84084 84084-21619928@events.umich.edu Event Begins: Wednesday, June 9, 2021 12:00pm
Location: Off Campus Location
Organized By: RISE (Research. Innovation. Scholarship. Education.)

Our next Virtual Talking Circle (VTC) will feature representatives from several units on campus that are leading the way in cultivating education innovation: The Center for Academic Innovation (CAI), Fast Forward Medical Innovation (FFMI), and the International Mixed Reality Grand Rounds.

Join us on Wednesday, June 9, 2021 from 12:00 - 1:00 PM to learn more about these units and how you can get involved in their education innovation activities. We hope you will also share other education innovation resources available to faculty, staff and learners.

All are welcome!

Register via Zoom at: https://umich.zoom.us/webinar/register/WN_xVYKDuaYSXa6AevHutqXBA

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Workshop / Seminar Thu, 20 May 2021 06:44:41 -0400 2021-06-09T12:00:00-04:00 2021-06-09T13:00:00-04:00 Off Campus Location RISE (Research. Innovation. Scholarship. Education.) Workshop / Seminar RISE Virtual Talking Circle
Safety Assessment of Autonomous Vehicles with a Naturalistic and Adversarial Driving Environment (June 9, 2021 1:00pm) https://events.umich.edu/event/84039 84039-21619637@events.umich.edu Event Begins: Wednesday, June 9, 2021 1:00pm
Location: Off Campus Location
Organized By: Center for Connected and Automated Transportation

Safety performance testing is critical to the development and deployment of autonomous vehicles (AVs). The prevailing approach life-like simulations of our driving environment. However, due to its high dimensionality and the rareness of safety-critical events, hundreds of millions of miles would be required to demonstrate an AV's safety performance.

The research in this presentation proposes a naturalistic and adversarial driving environment that can significantly reduce the required number of miles driven while simultaneously maintaining unbiasedness. Drs. Henry Liu and Shuo Feng will demonstrate the effectiveness of this in a highway-driving simulation.

Learn more about the proposed research: https://myumi.ch/BoQ2Q

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About the speakers:
Dr. Henry Liu is a professor in the Department of Civil and Environmental Engineering at the University of Michigan, a Research Professor at the University of Michigan Transportation Research Institute (UMTRI), and the Director for the Center for Connected and Automated Transportation (CCAT). Professor Liu conducts interdisciplinary research at the interface of transportation engineering, automotive engineering, and artificial intelligence. Specifically, his scholarly interests concern traffic flow monitoring, modeling, and control, as well as testing and evaluation of connected and automated vehicles (CAVs). He has published more than 120 refereed journal papers on these topics and his work has been widely recognized in the public media for promoting smart transportation innovations. He has appeared on media outlets including CNBC, Forbes, Technode, and more. In 2019, Professor Liu was invited to testify on the nation's transportation research agenda in front of the US House Subcommittee on Research and Technology. Professor Liu has nurtured a new generation of scholars, and some of his Ph.D. students and postdocs have joined first-class universities such as Columbia, Purdue, and RPI. Professor Liu is also the managing editor of the Journal of Intelligent Transportation Systems.

Dr. Shuo Feng is a postdoctoral research fellow in the Department of Civil and Environmental Engineering at the University of Michigan, Ann Arbor. He received his bachelor’s and Ph.D. degrees in the Department of Automation at Tsinghua University, China, in 2014 and 2019, respectively. He was also a visiting scholar at the University of Michigan from 2017 to 2019. His research interests lie in the testing and evaluation of connected and automated vehicles (CAVs), cooperative automation, and traffic environment modeling. Dr. Feng has published around 20 articles in refereed journals including Nature Communications, IEEE Transactions on Intelligent Transportation Systems, IEEE Transactions on Control Systems Technology, and Transportation Research Part C: Emerging Technologies. He has served as a member in the SAE ORAD V&V committee and workshop organizer of the IEEE 2021 Intelligent Vehicles Symposium. He received the “Best Ph.D. Dissertation Award” from the IEEE Intelligent Transportation Systems Society (ITSS) in 2020.

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Livestream / Virtual Thu, 13 May 2021 13:32:49 -0400 2021-06-09T13:00:00-04:00 2021-06-09T14:00:00-04:00 Off Campus Location Center for Connected and Automated Transportation Livestream / Virtual Decorative Image of the CCAT Research Review which features the speaker's headshots
EECS Juneteenth Celebration (June 18, 2021 1:00pm) https://events.umich.edu/event/84060 84060-21619781@events.umich.edu Event Begins: Friday, June 18, 2021 1:00pm
Location: Off Campus Location
Organized By: Electrical and Computer Engineering

https://umich.zoom.us/j/99331130203
Passcode: 719944

EECS invites you to our second Juneteenth celebration on Friday, June 18, from 1:00 – 2:00 p.m. ET.

Juneteenth is the oldest nationally celebrated commemoration of the ending of slavery in the United States. It celebrates African American freedom and achievement. Its goal is to promote and cultivate knowledge and appreciation of African American history and culture while encouraging continuous self-development and respect for all cultures. More info >

Our Juneteenth celebration will include:

-Performance of the Black National Anthem
-Reading of the Emancipation Proclamation
-Recognition of Dr. Willie Hobbs Moore, the first Black woman at Michigan to earn a BS and MS in Electrical Engineering (‘58 and ‘61), and the first Black woman in the country to earn a PhD in physics.
-Panel discussion on the representation of black students in STEM
All are welcome to attend to celebrate and learn!

If you have any problems accessing the event, please email eecs-comm@umich.edu.

Following the event, there will be an open Zoom meeting for additional questions and discussion.

https://umich.zoom.us/j/95094857220
Passcode: 010976

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Livestream / Virtual Mon, 17 May 2021 12:08:50 -0400 2021-06-18T13:00:00-04:00 2021-06-18T14:00:00-04:00 Off Campus Location Electrical and Computer Engineering Livestream / Virtual
2021 International Symposium on Transportation Data and Modelling (ISTDM) (June 21, 2021 8:00am) https://events.umich.edu/event/69501 69501-18954525@events.umich.edu Event Begins: Monday, June 21, 2021 8:00am
Location:
Organized By: Civil and Environmental Engineering

ISTDM 2021 aims to gather transportation researchers and practitioners across the globe for exploring the frontiers of big data, modeling and simulation to advance transportation research to support the connected, cooperative and automated mobility. With a greater focus on emerging technologies, ISTDM 2021 rebrands the two long-standing transportation symposia: International Symposium of Transport Simulation (ISTS), and the International Workshop on Traffic Data Collection and its Standardization (IWTDCS). During the three-day conference, plenary sessions featuring renowned speakers and interactive breakout sessions will take place at the University of Michigan in Ann Arbor, United States.

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Conference / Symposium Wed, 27 May 2020 15:07:08 -0400 2021-06-21T08:00:00-04:00 2021-06-21T18:00:00-04:00 Civil and Environmental Engineering Conference / Symposium transportation
2021 International Symposium on Transportation Data and Modeling (June 21, 2021 8:45am) https://events.umich.edu/event/83965 83965-21619227@events.umich.edu Event Begins: Monday, June 21, 2021 8:45am
Location: Off Campus Location
Organized By: Center for Connected and Automated Transportation

ISTDM 2021 aims to gather transportation researchers and practitioners across the globe for exploring the frontiers of big data, modeling, and simulation to advance transportation research to support the connected, cooperative, and automated mobility. With a greater focus on emerging technologies, ISTDM 2021 rebrands the two long-standing transportation symposia: International Symposium of Transport Simulation (ISTS), and the International Workshop on Traffic Data Collection and its Standardization (IWTDCS).

The conference program can be found at https://limos.engin.umich.edu/istdm2021/schedule/.

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Conference / Symposium Tue, 04 May 2021 10:27:16 -0400 2021-06-21T08:45:00-04:00 2021-06-21T12:20:00-04:00 Off Campus Location Center for Connected and Automated Transportation Conference / Symposium Banner Image for ISTDM 2021. It features headshots of the keynote speakers
2021 International Symposium on Transportation Data and Modelling (ISTDM) (June 22, 2021 8:00am) https://events.umich.edu/event/69501 69501-18954526@events.umich.edu Event Begins: Tuesday, June 22, 2021 8:00am
Location:
Organized By: Civil and Environmental Engineering

ISTDM 2021 aims to gather transportation researchers and practitioners across the globe for exploring the frontiers of big data, modeling and simulation to advance transportation research to support the connected, cooperative and automated mobility. With a greater focus on emerging technologies, ISTDM 2021 rebrands the two long-standing transportation symposia: International Symposium of Transport Simulation (ISTS), and the International Workshop on Traffic Data Collection and its Standardization (IWTDCS). During the three-day conference, plenary sessions featuring renowned speakers and interactive breakout sessions will take place at the University of Michigan in Ann Arbor, United States.

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Conference / Symposium Wed, 27 May 2020 15:07:08 -0400 2021-06-22T08:00:00-04:00 2021-06-22T18:00:00-04:00 Civil and Environmental Engineering Conference / Symposium transportation
Optimal Task-Invariant Energetic Control for Powered Exoskeletons (June 22, 2021 8:00am) https://events.umich.edu/event/84328 84328-21623343@events.umich.edu Event Begins: Tuesday, June 22, 2021 8:00am
Location: Off Campus Location
Organized By: Michigan Robotics

Powered exoskeletons have been developed to serve as rehabilitation devices and provide gait assistance to human users. It enhances a healthy person's abilities and supports a physically challenged person's daily life by providing powered hip, knee, and/or ankle motions with different control designs. State-of-art powered exoskeletons use trajectory-based, kinematic control methods for specific tasks. This type of control is appropriate for paraplegia, where the exoskeleton provides complete assistance. However, it overly constrains the volitional motion of people with remnant voluntary ability, e.g., stroke patients. In contrast, trajectory-free control methods are now being developed to provide task-invariant partial assistance for practicing/relearning leg motions or performing a continuum of activities in varying environments. Robotics systems like powered exoskeletons can be represented in the format of the Euler-Lagrange equation or the equivalent class, the port-controlled Hamiltonian equations. We use energy shaping methods for task-invariance by altering the human-exoskeleton system's dynamic characteristics via the Euler-Lagrange equations or the more general port-controlled Hamiltonian equations. Under satisfaction of the matching conditions, which is a set of nonlinear partial differential equations (PDEs), the open-loop system's mass/inertia matrix and gravitational vector can be mapped to the desired closed-loop system dynamics.

Energy shaping has broad applicability but has been limited in part by its computational and analytical complexity. Changes to the system dynamics must follow the solution to the matching conditions, while finding a solution to the matching conditions itself is challenging. The corresponding controller for kinetic energy shaping requires complicated calculations of the mass/inertia matrix inverse, where the computational cost for implementation increases tremendously. Potential energy shaping avoids the matrix inversion by altering only the potential energy but prevents shaping on the inertia terms. Such challenges require a new total energy shaping (TES) framework that provides flexible shaping structures with more freedom to change closed-loop dynamics over the potential energy shaping method. The corresponding control law with shaped structure also requires efforts to optimally achieve the powered exoskeletons' target control strategy for different locomotor tasks. Therefore, the specific aims of this project are: 1) construct a TES framework for powered exoskeletons with flexible shaping structure, 2) apply the framework to powered exoskeletons for optimal assistance across varying locomotor tasks, and 3) perform experiments on multiple human subjects to demonstrate the possible clinical benefits of optimal TES framework with powered lower-limb exoskeletons.

This work is significant to the viability and performance of energy shaping methods to nonlinear systems by simplifying the matching conditions and providing flexibility in inertia forces/torques compensation. In powered exoskeletons, inertia compensation does not require modifying the mass/inertia matrix with high dimensions, and the corresponding controllers are efficient for experimental implementation. The powered exoskeletons' target control strategy uses normative torque patterns to provide assistance or augment performance. We formulate an optimization problem to design the controller and produce joint torques that fit normative biological joint torques and offload musculature for walking on multiple tasks, including stairs. We perform experiments with multiple able-bodied human subjects wearing a knee-ankle exoskeleton to demonstrate reduced activation in certain lower-limb muscles on multiple tasks.

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Livestream / Virtual Mon, 21 Jun 2021 08:03:12 -0400 2021-06-22T08:00:00-04:00 2021-06-22T10:00:00-04:00 Off Campus Location Michigan Robotics Livestream / Virtual exoskeleton walking on treadmill
2021 International Symposium on Transportation Data and Modeling (June 22, 2021 8:45am) https://events.umich.edu/event/83965 83965-21619228@events.umich.edu Event Begins: Tuesday, June 22, 2021 8:45am
Location: Off Campus Location
Organized By: Center for Connected and Automated Transportation

ISTDM 2021 aims to gather transportation researchers and practitioners across the globe for exploring the frontiers of big data, modeling, and simulation to advance transportation research to support the connected, cooperative, and automated mobility. With a greater focus on emerging technologies, ISTDM 2021 rebrands the two long-standing transportation symposia: International Symposium of Transport Simulation (ISTS), and the International Workshop on Traffic Data Collection and its Standardization (IWTDCS).

The conference program can be found at https://limos.engin.umich.edu/istdm2021/schedule/.

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Conference / Symposium Tue, 04 May 2021 10:27:16 -0400 2021-06-22T08:45:00-04:00 2021-06-22T12:20:00-04:00 Off Campus Location Center for Connected and Automated Transportation Conference / Symposium Banner Image for ISTDM 2021. It features headshots of the keynote speakers
UM Single Cell Spatial Analysis Program (SCSAP) Kickoff Symposium (June 22, 2021 1:00pm) https://events.umich.edu/event/84222 84222-21620781@events.umich.edu Event Begins: Tuesday, June 22, 2021 1:00pm
Location: Off Campus Location
Organized By: Single Cell Spatial Analysis Program (SCSAP)

The UM BSI SINGLE CELL SPATIAL ANALYSIS PROGRAM KICK OFF SYMPOSIUM

Featuring Keynote Speaker Tzumin Lee, M.D. PhD.
Presenting: Linking single-cell genomics with single-cell genetics.

Date: June 22nd
Time: 1:00 pm -4:30 PM EST
Location: Zoom Webinar
Register at: https://umich.zoom.us/webinar/register/WN_Zax2iT5TReGILR_sQmIZ3w

Additional Mini-talks on: Spatial Transcriptomics, Single Cell RNA-Seq, CyTOF, Multispectral Imaging, Seq-SCOPE, Rare Cell Isolation.

Speakers:
Roger Cone, Ph.D. Evan Keller, Ph.D.
Thomas Wilson, M.D., Ph.D. Jun Li, Ph.D.
Tim Frankel, M.D. Sue Hammoud, Ph.D.
Jun Hee Lee, Ph.D. Olivia Koues, Ph.D.
Sunitha Nagrath, Ph.D. Justin Colacino, Ph.D.
Arvind Rao, Ph.D. Max S. Wicha, M.D.
Patricia Schnepp, Ph.D.

Find us at https://singlecellspatialanalysis.umich.edu
Questions/Comments please contact us at singlecellspatialanalysis@umich.edu

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Workshop / Seminar Fri, 04 Jun 2021 13:26:44 -0400 2021-06-22T13:00:00-04:00 2021-06-22T16:30:00-04:00 Off Campus Location Single Cell Spatial Analysis Program (SCSAP) Workshop / Seminar Dr. Tzumin Lee
2021 International Symposium on Transportation Data and Modelling (ISTDM) (June 23, 2021 8:00am) https://events.umich.edu/event/69501 69501-18954527@events.umich.edu Event Begins: Wednesday, June 23, 2021 8:00am
Location:
Organized By: Civil and Environmental Engineering

ISTDM 2021 aims to gather transportation researchers and practitioners across the globe for exploring the frontiers of big data, modeling and simulation to advance transportation research to support the connected, cooperative and automated mobility. With a greater focus on emerging technologies, ISTDM 2021 rebrands the two long-standing transportation symposia: International Symposium of Transport Simulation (ISTS), and the International Workshop on Traffic Data Collection and its Standardization (IWTDCS). During the three-day conference, plenary sessions featuring renowned speakers and interactive breakout sessions will take place at the University of Michigan in Ann Arbor, United States.

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Conference / Symposium Wed, 27 May 2020 15:07:08 -0400 2021-06-23T08:00:00-04:00 2021-06-23T18:00:00-04:00 Civil and Environmental Engineering Conference / Symposium transportation
Become a UROP Symposium Presentation Judge (June 23, 2021 8:00am) https://events.umich.edu/event/84344 84344-21623378@events.umich.edu Event Begins: Wednesday, June 23, 2021 8:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Provide your expertise during the 2021 Virtual Summer Research Symposium on August 4th. UROP is looking for graduate students, postdoctoral fellows, faculty and staff who are interested in awarding undergraduate researchers with a blue ribbon honors for their UROP presentation during symposium.

Become a UROP Symposium judge at: https://myumi.ch/1p1eY

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Conference / Symposium Tue, 22 Jun 2021 12:51:49 -0400 2021-06-23T08:00:00-04:00 2021-06-23T23:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Conference / Symposium Become a Symposium Judge
2021 International Symposium on Transportation Data and Modeling (June 23, 2021 8:45am) https://events.umich.edu/event/83965 83965-21619229@events.umich.edu Event Begins: Wednesday, June 23, 2021 8:45am
Location: Off Campus Location
Organized By: Center for Connected and Automated Transportation

ISTDM 2021 aims to gather transportation researchers and practitioners across the globe for exploring the frontiers of big data, modeling, and simulation to advance transportation research to support the connected, cooperative, and automated mobility. With a greater focus on emerging technologies, ISTDM 2021 rebrands the two long-standing transportation symposia: International Symposium of Transport Simulation (ISTS), and the International Workshop on Traffic Data Collection and its Standardization (IWTDCS).

The conference program can be found at https://limos.engin.umich.edu/istdm2021/schedule/.

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Conference / Symposium Tue, 04 May 2021 10:27:16 -0400 2021-06-23T08:45:00-04:00 2021-06-23T12:20:00-04:00 Off Campus Location Center for Connected and Automated Transportation Conference / Symposium Banner Image for ISTDM 2021. It features headshots of the keynote speakers
PhD Defense: Jiayue Cao (June 23, 2021 3:00pm) https://events.umich.edu/event/84287 84287-21621035@events.umich.edu Event Begins: Wednesday, June 23, 2021 3:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

The stomach and brain interact closely with each other. Their interactions are central to digestive functions and the “gut feeling”. The neural pathways that mediate the stomach-brain interactions include the vagus nerve and the thoracic nerve. Through these nerves, the stomach can relay neural signals to a number of brain regions that span a central gastric network. This gastric network allows the brain to monitor and regulate gastric physiology and allows the stomach to influence emotion and cognition. Impairment of this gastric network may lead to both gastric and neurological disorders, e.g., anxiety, gastroparesis, functional dyspepsia, and obesity. However, the structural constituents and functional roles of the central gastric network remain unclear. In my dissertation research, I leveraged complementary techniques to characterize the central gastric network in rats across a wide range of scales and different gastric states. In animal experiments, I used functional magnetic resonance imaging (fMRI) to map brain activity synchronized with gastric electrical activity and to map brain activations induced by electrical stimulation applied to the cervical vagus or its afferent terminals on the stomach. I also used neurophysiology to characterize gastric neurons in brainstem in response to gastric electrical stimulation. Results from my studies suggest that 1) gastric neurons in the brainstem are selective to the orientation of muscle activity relayed through intramuscular arrays, 2) the central gastric network is intrinsically coupled to gastric slow waves and their amplitude fluctuations primarily via vagal signaling, 3) selective stimulation of the vagus can evoke widespread and fast brain responses and alter functional connectivity within and beyond the central gastric network. My dissertation research contributes to the foundation of mapping and characterizing the central and peripheral mechanisms of gastric interoception and sheds new light on where and how to stimulate the peripheral nerves to modulate stomach-brain interactions.



Date: Wednesday, June 23, 2021

Time: 3:00 PM

Zoom: https://umich.zoom.us/j/2757414653

Chair: Dr. Zhongming Liu

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Lecture / Discussion Tue, 15 Jun 2021 23:04:33 -0400 2021-06-23T15:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Become a UROP Symposium Presentation Judge (June 24, 2021 8:00am) https://events.umich.edu/event/84344 84344-21623379@events.umich.edu Event Begins: Thursday, June 24, 2021 8:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Provide your expertise during the 2021 Virtual Summer Research Symposium on August 4th. UROP is looking for graduate students, postdoctoral fellows, faculty and staff who are interested in awarding undergraduate researchers with a blue ribbon honors for their UROP presentation during symposium.

Become a UROP Symposium judge at: https://myumi.ch/1p1eY

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Conference / Symposium Tue, 22 Jun 2021 12:51:49 -0400 2021-06-24T08:00:00-04:00 2021-06-24T23:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Conference / Symposium Become a Symposium Judge
2021 International Symposium on Transportation Data and Modeling (June 24, 2021 8:45am) https://events.umich.edu/event/83965 83965-21619230@events.umich.edu Event Begins: Thursday, June 24, 2021 8:45am
Location: Off Campus Location
Organized By: Center for Connected and Automated Transportation

ISTDM 2021 aims to gather transportation researchers and practitioners across the globe for exploring the frontiers of big data, modeling, and simulation to advance transportation research to support the connected, cooperative, and automated mobility. With a greater focus on emerging technologies, ISTDM 2021 rebrands the two long-standing transportation symposia: International Symposium of Transport Simulation (ISTS), and the International Workshop on Traffic Data Collection and its Standardization (IWTDCS).

The conference program can be found at https://limos.engin.umich.edu/istdm2021/schedule/.

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Conference / Symposium Tue, 04 May 2021 10:27:16 -0400 2021-06-24T08:45:00-04:00 2021-06-24T12:20:00-04:00 Off Campus Location Center for Connected and Automated Transportation Conference / Symposium Banner Image for ISTDM 2021. It features headshots of the keynote speakers
PhD Defense: Eric Charles Hobson (June 24, 2021 10:30am) https://events.umich.edu/event/84237 84237-21620794@events.umich.edu Event Begins: Thursday, June 24, 2021 10:30am
Location: Off Campus Location
Organized By: Biomedical Engineering

Mechanical testing of viscoelastic biomaterials is of critical importance in biomedical engineering, enabling basic research into the role of the extracellular matrix, investigatory and diagnostic testing of tissues and biofluids, and the development and characterization of tissue engineered therapeutics. Conventional material testing approaches used for soft biomaterials generally require force application through direct contact with a sample, leading to potential contamination and damage, and thereby limiting these approaches to end-point measurements. To overcome these limitations, we have developed a new measurement technique, Resonant Acoustic Rheometry (RAR), which enables high-throughput, quantitative, and non-contact viscoelastic characterization of biomaterials, soft tissues, and biological fluids.



RAR uses ultrasonic pulses to both generate microscale perturbations and measure the resulting resonant oscillations at the surface of soft materials using standard labware. Resonant oscillatory properties obtained from the frequency spectra of the surface oscillations, including the resonant frequency and the damping coefficient, are used to quantify material properties such as shear modulus, shear viscosity, and surface tension in both viscoelastic solids and liquids.



We developed a prototype RAR system and tested it on a range of soft biomaterials, with shear moduli ranging from under 100 Pa to over 50 kPa, including fibrin, gelatin, and polyethylene glycol (PEG). Shear moduli measured using RAR were validated both computationally using finite element analysis and experimentally using conventional shear rheometry, with excellent linear correlation in measured elasticity between techniques (R2 > 0.95). By performing parallel RAR experiments using microwells of different sizes, we verified that resonant oscillatory behaviors could be used to quantify the intrinsic viscoelastic properties of a material. We also demonstrated the rapid, non-contact monitoring of changes in material properties over a variety of temporal scales, ranging from processes occurring on the order of milliseconds to those occurring over hours and days. High temporal resolution RAR measurements, with sampling intervals as low as 0.2 seconds, were used to characterize the gelation process. Characteristic features of the resonant surface waves during phase transition were applied to identify the gel point for various hydrogels. High sample throughput was demonstrated by performing longitudinal RAR testing to explore the impact of hydrogel polymer and crosslinker concentration on both reaction kinetics and final mechanical properties in full factorial experiments consisting of over 15,000 unique measurements. We were able to identify individual effects of design parameters as well as interactions that led to unexpected mechanical properties, demonstrating the importance of combinatorial methods and high-throughput mechanical characterization in material design.



These studies demonstrate that RAR can rapidly and accurately assess the mechanical properties of soft viscoelastic biomaterials. The measurements generated are analogous to those produced using conventional mechanical testing, and RAR is further capable of longitudinal viscoelastic studies over time. RAR applies automation in both data collection and analysis, allowing high throughput measurement of an array of samples without contact or the need for manual intervention. Furthermore, RAR uses standard microwell plates, which simplifies sample preparation and handling. The viscoelastic properties of soft biomaterials are relevant in a wide range of applications, including for clinical diagnostic assays and the development of hydrogel materials for regenerative medicine. RAR represents a fast, accurate, and cost-effective method for materials characterization in these applications.



June 24 - 10:30 AM

Zoom: https://umich.zoom.us/meeting/register/tJcsd-iurTosGdNn_gR-FbOCe5TUR09Y58WV

Co-Chairs: Dr. Cheri Deng and Dr. Jan Stegmann

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Lecture / Discussion Tue, 22 Jun 2021 16:37:33 -0400 2021-06-24T10:30:00-04:00 2021-06-24T11:30:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Become a UROP Symposium Presentation Judge (June 25, 2021 8:00am) https://events.umich.edu/event/84344 84344-21623380@events.umich.edu Event Begins: Friday, June 25, 2021 8:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Provide your expertise during the 2021 Virtual Summer Research Symposium on August 4th. UROP is looking for graduate students, postdoctoral fellows, faculty and staff who are interested in awarding undergraduate researchers with a blue ribbon honors for their UROP presentation during symposium.

Become a UROP Symposium judge at: https://myumi.ch/1p1eY

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Conference / Symposium Tue, 22 Jun 2021 12:51:49 -0400 2021-06-25T08:00:00-04:00 2021-06-25T23:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Conference / Symposium Become a Symposium Judge
Become a UROP Symposium Presentation Judge (June 26, 2021 8:00am) https://events.umich.edu/event/84344 84344-21623381@events.umich.edu Event Begins: Saturday, June 26, 2021 8:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Provide your expertise during the 2021 Virtual Summer Research Symposium on August 4th. UROP is looking for graduate students, postdoctoral fellows, faculty and staff who are interested in awarding undergraduate researchers with a blue ribbon honors for their UROP presentation during symposium.

Become a UROP Symposium judge at: https://myumi.ch/1p1eY

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Conference / Symposium Tue, 22 Jun 2021 12:51:49 -0400 2021-06-26T08:00:00-04:00 2021-06-26T23:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Conference / Symposium Become a Symposium Judge
Become a UROP Symposium Presentation Judge (June 27, 2021 8:00am) https://events.umich.edu/event/84344 84344-21623382@events.umich.edu Event Begins: Sunday, June 27, 2021 8:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Provide your expertise during the 2021 Virtual Summer Research Symposium on August 4th. UROP is looking for graduate students, postdoctoral fellows, faculty and staff who are interested in awarding undergraduate researchers with a blue ribbon honors for their UROP presentation during symposium.

Become a UROP Symposium judge at: https://myumi.ch/1p1eY

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Conference / Symposium Tue, 22 Jun 2021 12:51:49 -0400 2021-06-27T08:00:00-04:00 2021-06-27T23:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Conference / Symposium Become a Symposium Judge
Become a UROP Symposium Presentation Judge (June 28, 2021 8:00am) https://events.umich.edu/event/84344 84344-21623383@events.umich.edu Event Begins: Monday, June 28, 2021 8:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Provide your expertise during the 2021 Virtual Summer Research Symposium on August 4th. UROP is looking for graduate students, postdoctoral fellows, faculty and staff who are interested in awarding undergraduate researchers with a blue ribbon honors for their UROP presentation during symposium.

Become a UROP Symposium judge at: https://myumi.ch/1p1eY

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Conference / Symposium Tue, 22 Jun 2021 12:51:49 -0400 2021-06-28T08:00:00-04:00 2021-06-28T23:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Conference / Symposium Become a Symposium Judge
BME Master's Defense: Spencer Morris (June 28, 2021 10:00am) https://events.umich.edu/event/84342 84342-21623372@events.umich.edu Event Begins: Monday, June 28, 2021 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

Acquiring accurate measurements for blood flow is a clinically relevant problem of interest. Three-dimensional color flow with partial volume correction (PVC) is a relatively new method for measuring blood flow that accounts for beams located partially outside of the blood vessel. Recent work has shown that the relationship between color flow power and partially perfused voxels is nonlinear. This work investigates the statistics of color power measurements in simulated plug flow to help explain this nonlinear behavior. Data was acquired using Field II simulations in which a 3.75 MHz mechanically swept linear array obtained RF data of blood moving through a vessel. Blood in the vessel exhibited plug flow, and tissue backscatter was set to 40 dB below blood. The statistics of color power at each point in the processing chain were analyzed using histograms, established results in ultrasound statistics, and derived probability density functions (pdfs). For locations completely inside the beam, power before additional processing showed exponential behavior, whereas the square root of power, i.e., amplitude, was Rician distributed. After implementing the Kasai algorithm, the power values could be estimated with a gamma distribution with a shape parameter of 2.21. Kasai powers corresponding to tissue could also be fitted with a gamma distribution, albeit with a shape parameter close to 1, indicating close to exponential behavior. Kasai powers for partial volume data were intermediate between the tissue and blood data. A method for estimating partial volume weight from the skewness and kurtosis of samples taken from the same location is also discussed.

Date: Monday, June 28, 2021
Time: 10:00 AM
Zoom: https://umich.zoom.us/j/97162930417
Chair: Dr. Oliver Kripfgans

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Presentation Tue, 22 Jun 2021 11:48:21 -0400 2021-06-28T10:00:00-04:00 2021-06-28T11:00:00-04:00 Off Campus Location Biomedical Engineering Presentation BME Event
Become a UROP Symposium Presentation Judge (June 29, 2021 8:00am) https://events.umich.edu/event/84344 84344-21623384@events.umich.edu Event Begins: Tuesday, June 29, 2021 8:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Provide your expertise during the 2021 Virtual Summer Research Symposium on August 4th. UROP is looking for graduate students, postdoctoral fellows, faculty and staff who are interested in awarding undergraduate researchers with a blue ribbon honors for their UROP presentation during symposium.

Become a UROP Symposium judge at: https://myumi.ch/1p1eY

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Conference / Symposium Tue, 22 Jun 2021 12:51:49 -0400 2021-06-29T08:00:00-04:00 2021-06-29T23:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Conference / Symposium Become a Symposium Judge
Become a UROP Symposium Presentation Judge (June 30, 2021 8:00am) https://events.umich.edu/event/84344 84344-21623385@events.umich.edu Event Begins: Wednesday, June 30, 2021 8:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Provide your expertise during the 2021 Virtual Summer Research Symposium on August 4th. UROP is looking for graduate students, postdoctoral fellows, faculty and staff who are interested in awarding undergraduate researchers with a blue ribbon honors for their UROP presentation during symposium.

Become a UROP Symposium judge at: https://myumi.ch/1p1eY

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Conference / Symposium Tue, 22 Jun 2021 12:51:49 -0400 2021-06-30T08:00:00-04:00 2021-06-30T23:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Conference / Symposium Become a Symposium Judge
Become a UROP Symposium Presentation Judge (July 1, 2021 8:00am) https://events.umich.edu/event/84344 84344-21623386@events.umich.edu Event Begins: Thursday, July 1, 2021 8:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Provide your expertise during the 2021 Virtual Summer Research Symposium on August 4th. UROP is looking for graduate students, postdoctoral fellows, faculty and staff who are interested in awarding undergraduate researchers with a blue ribbon honors for their UROP presentation during symposium.

Become a UROP Symposium judge at: https://myumi.ch/1p1eY

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Conference / Symposium Tue, 22 Jun 2021 12:51:49 -0400 2021-07-01T08:00:00-04:00 2021-07-01T23:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Conference / Symposium Become a Symposium Judge
Become a UROP Symposium Presentation Judge (July 2, 2021 8:00am) https://events.umich.edu/event/84344 84344-21623387@events.umich.edu Event Begins: Friday, July 2, 2021 8:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Provide your expertise during the 2021 Virtual Summer Research Symposium on August 4th. UROP is looking for graduate students, postdoctoral fellows, faculty and staff who are interested in awarding undergraduate researchers with a blue ribbon honors for their UROP presentation during symposium.

Become a UROP Symposium judge at: https://myumi.ch/1p1eY

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Conference / Symposium Tue, 22 Jun 2021 12:51:49 -0400 2021-07-02T08:00:00-04:00 2021-07-02T23:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Conference / Symposium Become a Symposium Judge
Become a UROP Symposium Presentation Judge (July 3, 2021 8:00am) https://events.umich.edu/event/84344 84344-21623388@events.umich.edu Event Begins: Saturday, July 3, 2021 8:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Provide your expertise during the 2021 Virtual Summer Research Symposium on August 4th. UROP is looking for graduate students, postdoctoral fellows, faculty and staff who are interested in awarding undergraduate researchers with a blue ribbon honors for their UROP presentation during symposium.

Become a UROP Symposium judge at: https://myumi.ch/1p1eY

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Conference / Symposium Tue, 22 Jun 2021 12:51:49 -0400 2021-07-03T08:00:00-04:00 2021-07-03T23:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Conference / Symposium Become a Symposium Judge
Become a UROP Symposium Presentation Judge (July 4, 2021 8:00am) https://events.umich.edu/event/84344 84344-21623389@events.umich.edu Event Begins: Sunday, July 4, 2021 8:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Provide your expertise during the 2021 Virtual Summer Research Symposium on August 4th. UROP is looking for graduate students, postdoctoral fellows, faculty and staff who are interested in awarding undergraduate researchers with a blue ribbon honors for their UROP presentation during symposium.

Become a UROP Symposium judge at: https://myumi.ch/1p1eY

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Conference / Symposium Tue, 22 Jun 2021 12:51:49 -0400 2021-07-04T08:00:00-04:00 2021-07-04T23:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Conference / Symposium Become a Symposium Judge
Become a UROP Symposium Presentation Judge (July 5, 2021 8:00am) https://events.umich.edu/event/84344 84344-21623390@events.umich.edu Event Begins: Monday, July 5, 2021 8:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Provide your expertise during the 2021 Virtual Summer Research Symposium on August 4th. UROP is looking for graduate students, postdoctoral fellows, faculty and staff who are interested in awarding undergraduate researchers with a blue ribbon honors for their UROP presentation during symposium.

Become a UROP Symposium judge at: https://myumi.ch/1p1eY

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Conference / Symposium Tue, 22 Jun 2021 12:51:49 -0400 2021-07-05T08:00:00-04:00 2021-07-05T23:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Conference / Symposium Become a Symposium Judge
Become a UROP Symposium Presentation Judge (July 6, 2021 8:00am) https://events.umich.edu/event/84344 84344-21623391@events.umich.edu Event Begins: Tuesday, July 6, 2021 8:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Provide your expertise during the 2021 Virtual Summer Research Symposium on August 4th. UROP is looking for graduate students, postdoctoral fellows, faculty and staff who are interested in awarding undergraduate researchers with a blue ribbon honors for their UROP presentation during symposium.

Become a UROP Symposium judge at: https://myumi.ch/1p1eY

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Conference / Symposium Tue, 22 Jun 2021 12:51:49 -0400 2021-07-06T08:00:00-04:00 2021-07-06T23:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Conference / Symposium Become a Symposium Judge
Become a UROP Symposium Presentation Judge (July 7, 2021 8:00am) https://events.umich.edu/event/84344 84344-21623392@events.umich.edu Event Begins: Wednesday, July 7, 2021 8:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Provide your expertise during the 2021 Virtual Summer Research Symposium on August 4th. UROP is looking for graduate students, postdoctoral fellows, faculty and staff who are interested in awarding undergraduate researchers with a blue ribbon honors for their UROP presentation during symposium.

Become a UROP Symposium judge at: https://myumi.ch/1p1eY

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Conference / Symposium Tue, 22 Jun 2021 12:51:49 -0400 2021-07-07T08:00:00-04:00 2021-07-07T23:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Conference / Symposium Become a Symposium Judge
Become a UROP Symposium Presentation Judge (July 8, 2021 8:00am) https://events.umich.edu/event/84344 84344-21623393@events.umich.edu Event Begins: Thursday, July 8, 2021 8:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Provide your expertise during the 2021 Virtual Summer Research Symposium on August 4th. UROP is looking for graduate students, postdoctoral fellows, faculty and staff who are interested in awarding undergraduate researchers with a blue ribbon honors for their UROP presentation during symposium.

Become a UROP Symposium judge at: https://myumi.ch/1p1eY

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Conference / Symposium Tue, 22 Jun 2021 12:51:49 -0400 2021-07-08T08:00:00-04:00 2021-07-08T23:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Conference / Symposium Become a Symposium Judge
Become a UROP Symposium Presentation Judge (July 9, 2021 8:00am) https://events.umich.edu/event/84344 84344-21623394@events.umich.edu Event Begins: Friday, July 9, 2021 8:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Provide your expertise during the 2021 Virtual Summer Research Symposium on August 4th. UROP is looking for graduate students, postdoctoral fellows, faculty and staff who are interested in awarding undergraduate researchers with a blue ribbon honors for their UROP presentation during symposium.

Become a UROP Symposium judge at: https://myumi.ch/1p1eY

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Conference / Symposium Tue, 22 Jun 2021 12:51:49 -0400 2021-07-09T08:00:00-04:00 2021-07-09T23:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Conference / Symposium Become a Symposium Judge
PhD Defense: Hans Zander (July 9, 2021 9:00am) https://events.umich.edu/event/84346 84346-21623406@events.umich.edu Event Begins: Friday, July 9, 2021 9:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

Spinal cord stimulation (SCS) is a neuromodulation technique that applies electrical stimulation to the spinal cord to alter neural activity or processing. While SCS has historically been used as a last resort therapy for chronic pain management, novel applications and technologies have recently been developed that either increase the efficacy of treatment for chronic pain or drive neural activity to produce muscular activity/movement following a paralyzing spinal cord injury (SCI). Despite these recent innovations, there remain fundamental questions concerning the neural recruitment underlying these efficacious results. This work evaluated the neural activity and mechanisms for two novel SCS applications: closed-loop spinal cord stimulation for pain management, and ventral, high frequency spinal cord stimulation (HF-SCS) for inspiratory muscle activation following a SCI.

To evaluate neural activity, I developed computational models of SCS. Models consisted of 3 components: a finite element model (FEM) of the spinal cord to predict voltages during stimulation, biophysical neuron models, and algorithms to apply time-dependent extracellular voltages to the neuron models and simulate their response. While this cutting-edge modeling methodology could be used to predict neural activity following stimulation, it was unclear how common anatomical or technical model simplifications affected neural predictions. Therefore, the initial goal of this work was to evaluate how modeling assumptions influence neural behavior.

My initial work identified how several relevant anatomical and technical factors influence model predictions of neural activity. To evaluate these factors, I designed an FEM of a T9 thoracic spine with an implanted electrode. Then, I sequentially removed details from the model and quantified the changes in neural predictions. I identified several factors with profound (>30%) impacts on neural thresholds, including overall model impedance (for voltage-controlled stimulation), the presence of a detailed vertebral column, and dura mater conductivity. I also identified several factors that could safely be ignored in future models. This work will be invaluable as a guide for future model development.

Next, I developed a canine model to evaluate T2 ventral HF-SCS for inspiratory muscle activation. I designed and positioned two neuron models hypothesized to lead to inspiratory behavior: ventrolateral funiculus fibers (VLF) leading to diaphragm activation and inspiratory intercostal motoneurons. With this model, I predicted robust VLF and T2-T5 motoneuron recruitment within the physiologic range of stimulation. Additionally, I designed two stimulation leads that maximize inspiratory neuron recruitment. The finalized leads were evaluated via in vivo experiments, which found excellent agreement with the model. This work builds our mechanistic understanding of this novel therapy, improves its implementation, and aids in future translational efforts towards human subjects.

Finally, I developed a computational model to evaluate closed-loop stimulation for chronic pain. This work characterized the neural origins of the evoked compound action potential (ECAP), the controlling biomarker of closed-loop stimulation. I modified my modeling methodology to predict ECAPs generated during low thoracic dorsal stimulation in humans, which matched with experimental measurements. This modeling work showed that ECAP properties depend on activation of a narrow range of neuron diameters and quantified how anatomical and stimulation factors (CSF thickness, stimulation configuration, lead position, pulse width) influence ECAP morphology, timing, and neural recruitment. These results improve our mechanistic understanding of closed-loop stimulation and may lead to expanded clinical utility as well as better validation of future SCS computational models.

Date: Friday, July 9, 2021

Time: 9:00 AM EDT

Zoom: https://umich.zoom.us/j/96847307388

Chair: Dr. Scott Lempka

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Lecture / Discussion Tue, 22 Jun 2021 16:45:26 -0400 2021-07-09T09:00:00-04:00 2021-07-09T10:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Logo
Become a UROP Symposium Presentation Judge (July 10, 2021 8:00am) https://events.umich.edu/event/84344 84344-21623395@events.umich.edu Event Begins: Saturday, July 10, 2021 8:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Provide your expertise during the 2021 Virtual Summer Research Symposium on August 4th. UROP is looking for graduate students, postdoctoral fellows, faculty and staff who are interested in awarding undergraduate researchers with a blue ribbon honors for their UROP presentation during symposium.

Become a UROP Symposium judge at: https://myumi.ch/1p1eY

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Conference / Symposium Tue, 22 Jun 2021 12:51:49 -0400 2021-07-10T08:00:00-04:00 2021-07-10T23:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Conference / Symposium Become a Symposium Judge
Become a UROP Symposium Presentation Judge (July 11, 2021 8:00am) https://events.umich.edu/event/84344 84344-21623396@events.umich.edu Event Begins: Sunday, July 11, 2021 8:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Provide your expertise during the 2021 Virtual Summer Research Symposium on August 4th. UROP is looking for graduate students, postdoctoral fellows, faculty and staff who are interested in awarding undergraduate researchers with a blue ribbon honors for their UROP presentation during symposium.

Become a UROP Symposium judge at: https://myumi.ch/1p1eY

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Conference / Symposium Tue, 22 Jun 2021 12:51:49 -0400 2021-07-11T08:00:00-04:00 2021-07-11T23:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Conference / Symposium Become a Symposium Judge
Become a UROP Symposium Presentation Judge (July 12, 2021 8:00am) https://events.umich.edu/event/84344 84344-21623397@events.umich.edu Event Begins: Monday, July 12, 2021 8:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Provide your expertise during the 2021 Virtual Summer Research Symposium on August 4th. UROP is looking for graduate students, postdoctoral fellows, faculty and staff who are interested in awarding undergraduate researchers with a blue ribbon honors for their UROP presentation during symposium.

Become a UROP Symposium judge at: https://myumi.ch/1p1eY

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Conference / Symposium Tue, 22 Jun 2021 12:51:49 -0400 2021-07-12T08:00:00-04:00 2021-07-12T23:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Conference / Symposium Become a Symposium Judge
Become a UROP Symposium Presentation Judge (July 13, 2021 8:00am) https://events.umich.edu/event/84344 84344-21623398@events.umich.edu Event Begins: Tuesday, July 13, 2021 8:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Provide your expertise during the 2021 Virtual Summer Research Symposium on August 4th. UROP is looking for graduate students, postdoctoral fellows, faculty and staff who are interested in awarding undergraduate researchers with a blue ribbon honors for their UROP presentation during symposium.

Become a UROP Symposium judge at: https://myumi.ch/1p1eY

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Conference / Symposium Tue, 22 Jun 2021 12:51:49 -0400 2021-07-13T08:00:00-04:00 2021-07-13T23:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Conference / Symposium Become a Symposium Judge
Become a UROP Symposium Presentation Judge (July 14, 2021 8:00am) https://events.umich.edu/event/84344 84344-21623399@events.umich.edu Event Begins: Wednesday, July 14, 2021 8:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Provide your expertise during the 2021 Virtual Summer Research Symposium on August 4th. UROP is looking for graduate students, postdoctoral fellows, faculty and staff who are interested in awarding undergraduate researchers with a blue ribbon honors for their UROP presentation during symposium.

Become a UROP Symposium judge at: https://myumi.ch/1p1eY

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Conference / Symposium Tue, 22 Jun 2021 12:51:49 -0400 2021-07-14T08:00:00-04:00 2021-07-14T23:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Conference / Symposium Become a Symposium Judge
Become a UROP Symposium Presentation Judge (July 15, 2021 8:00am) https://events.umich.edu/event/84344 84344-21623400@events.umich.edu Event Begins: Thursday, July 15, 2021 8:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Provide your expertise during the 2021 Virtual Summer Research Symposium on August 4th. UROP is looking for graduate students, postdoctoral fellows, faculty and staff who are interested in awarding undergraduate researchers with a blue ribbon honors for their UROP presentation during symposium.

Become a UROP Symposium judge at: https://myumi.ch/1p1eY

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Conference / Symposium Tue, 22 Jun 2021 12:51:49 -0400 2021-07-15T08:00:00-04:00 2021-07-15T23:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Conference / Symposium Become a Symposium Judge
New Urban Mobility: Transformations and & Value Creation (July 15, 2021 1:00pm) https://events.umich.edu/event/84276 84276-21621021@events.umich.edu Event Begins: Thursday, July 15, 2021 1:00pm
Location: Off Campus Location
Organized By: Center for Connected and Automated Transportation

Currently, urban mobility is facing several challenges: some are the result of long-term urbanization trends and others are the outcome of more recent changes to population behaviors. Addressing these challenges requires systems thinking and a broadening of collaboration between automakers, mobility services companies, and cities. These constituencies must transform, which will determine their new roles in the new, urban mobility. New value chains will emerge along with novel forms of value that will be realized through innovative business models. This presentation, brought to us by Evangelos Simoudis, Ph.D., will highlight the decisions automakers, mobility service companies, and cities must make, and the transformations they will undergo with regards to technology and business models. Dr. Simoudis will also discuss the risks arising from the use of data and artificial intelligence in new, urban mobility.

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Livestream / Virtual Mon, 14 Jun 2021 09:14:48 -0400 2021-07-15T13:00:00-04:00 2021-07-15T14:00:00-04:00 Off Campus Location Center for Connected and Automated Transportation Livestream / Virtual Decorative Image for CCAT Distinguished Lecture Series with Evangelos Simoudis
Become a UROP Symposium Presentation Judge (July 16, 2021 8:00am) https://events.umich.edu/event/84344 84344-21623401@events.umich.edu Event Begins: Friday, July 16, 2021 8:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Provide your expertise during the 2021 Virtual Summer Research Symposium on August 4th. UROP is looking for graduate students, postdoctoral fellows, faculty and staff who are interested in awarding undergraduate researchers with a blue ribbon honors for their UROP presentation during symposium.

Become a UROP Symposium judge at: https://myumi.ch/1p1eY

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Conference / Symposium Tue, 22 Jun 2021 12:51:49 -0400 2021-07-16T08:00:00-04:00 2021-07-16T23:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Conference / Symposium Become a Symposium Judge
Become a UROP Symposium Presentation Judge (July 17, 2021 8:00am) https://events.umich.edu/event/84344 84344-21623402@events.umich.edu Event Begins: Saturday, July 17, 2021 8:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Provide your expertise during the 2021 Virtual Summer Research Symposium on August 4th. UROP is looking for graduate students, postdoctoral fellows, faculty and staff who are interested in awarding undergraduate researchers with a blue ribbon honors for their UROP presentation during symposium.

Become a UROP Symposium judge at: https://myumi.ch/1p1eY

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Conference / Symposium Tue, 22 Jun 2021 12:51:49 -0400 2021-07-17T08:00:00-04:00 2021-07-17T23:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Conference / Symposium Become a Symposium Judge
Become a UROP Symposium Presentation Judge (July 18, 2021 8:00am) https://events.umich.edu/event/84344 84344-21623403@events.umich.edu Event Begins: Sunday, July 18, 2021 8:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Provide your expertise during the 2021 Virtual Summer Research Symposium on August 4th. UROP is looking for graduate students, postdoctoral fellows, faculty and staff who are interested in awarding undergraduate researchers with a blue ribbon honors for their UROP presentation during symposium.

Become a UROP Symposium judge at: https://myumi.ch/1p1eY

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Conference / Symposium Tue, 22 Jun 2021 12:51:49 -0400 2021-07-18T08:00:00-04:00 2021-07-18T23:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Conference / Symposium Become a Symposium Judge
Become a UROP Symposium Presentation Judge (July 19, 2021 8:00am) https://events.umich.edu/event/84344 84344-21623404@events.umich.edu Event Begins: Monday, July 19, 2021 8:00am
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Provide your expertise during the 2021 Virtual Summer Research Symposium on August 4th. UROP is looking for graduate students, postdoctoral fellows, faculty and staff who are interested in awarding undergraduate researchers with a blue ribbon honors for their UROP presentation during symposium.

Become a UROP Symposium judge at: https://myumi.ch/1p1eY

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Conference / Symposium Tue, 22 Jun 2021 12:51:49 -0400 2021-07-19T08:00:00-04:00 2021-07-19T23:00:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Conference / Symposium Become a Symposium Judge
BME Ph.D. Defense: Michael Bregenzer (July 21, 2021 9:00am) https://events.umich.edu/event/84438 84438-21623984@events.umich.edu Event Begins: Wednesday, July 21, 2021 9:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

High grade serous ovarian cancer (HGSOC) is the deadliest gynecological malignancy. Despite successful first line therapies, most patients relapse and develop more chemoresistant disease. This recurrence and development of chemoresistance is attributed to a rare population of tumor cells, termed cancer stem cells (CSCs), which are more chemoresistant, have the capacity to self-renew, and can repopulate the entire tumor. Research has shown that CSCs are maintained by the non-cancer cells in the tumor microenvironment (TME), such as mesenchymal stem cells (MSCs), endothelial cells (ECs), and immune cells. Furthermore, the role of non-cancer cells in clinical outcomes and chemoresistance has been highlighted by recent evidence showing that classification of HGSOC molecular subtypes, which have variable clinical prognoses, are influenced by the presence of non-cancer cells in the tumor. However, it is currently unclear exactly how CSCs and the nuanced cell composition of the TME work together to promote chemoresistance. Current models used to study these phenomena either suffer from a lack of cellular complexity in the case of many in vitro models or impractical experimental constraints such as long latency periods and poor control over cell composition in patient-derived xenografts. To better understand the role of CSCs and the TME cells in chemoresistance, practical in vitro model systems that more closely represent in vivo processes and microenvironments are needed. We hypothesize that the development of these in vitro model systems will contribute novel insights into TME-mediated CSC regulation and the development of chemoresistance in HGSOC.

In aim 1 we examined the emergence of chemoresistance in the context of CSCs by developing a 3D in vitro serial passaging model system that allows for long term culture of patient-derived tumor cells with periodic evaluation of stemness and chemoresistance. Using this model system, we demonstrated increased proliferation, expression of CSC markers, tumorigenicity, and chemoresistance over the course of long-term passaging, reflective of emerging chemoresistance in vivo. Furthermore, this system enabled us to define a malignant gene expression signature that is associated with chemoresistance, tumorigenicity, and stemness and to evaluate patient-specific chemoresistance development following treatment. Finally, we demonstrated the translational value of this model system by showing that Metformin treatment can hinder CSC driven development of chemoresistance in a phase II clinical trial.

In aim 2 we developed a heterogeneous tumoroid culture system that enabled culture of patient-derived tumor cells with controlled ratios of MSCs, ECs, and immune cells to study TME-mediated maintenance of CSCs and chemoresistance. Using this model, we found that changes in CD133+/-ALDH+/- CSC phenotypes in response to TME cells varied depending on the patient sample. We also observed increased tumorigenicity and chemoresistance in tumoroids compared to spheroids cultured with patient-derived tumor cells alone. Furthermore, we found evidence of epithelial-to-mesenchymal transition (EMT) in tumoroids accompanied by altered CSC phenotypes and a malignant matrisome signature. All of this together supports idea that the non-cancer cells in the TME contribute to the development of advanced, chemoresistant disease and implicates EMT, changes in CSC phenotypes, and matrix remodeling as the primary culprits.

Finally, in aim 3, we utilized this tumoroid system to generate tumoroids with 23 different cell compositions to evaluate the role of TME cell composition in response to therapy. Drug assays with novel and traditional chemotherapies revealed that tumoroids with different compositions respond differently to therapy and that the number of monocytes included in the culture was associated with the greatest resistance to therapy. Furthermore, our random forest models trained on the drug responses of each cell composition were able to predict drug response with moderate success. With these models we identified that nuanced differences in cell composition can influence drug response and that the strongest predictor of response to therapy was the total quantity of non-cancer cells. Overall, this model demonstrates the potential of using the TME composition to predict patient drug response and direct clinical management.

In these aims we demonstrate the clear utility of complex and realistic, yet practical in vitro model systems in the study of chemoresistance and CSC maintenance in ovarian cancer. Specifically, we identified the link between CSCs and the development of chemoresistance in long term 3D in vitro serial passage culture. Furthermore, we showed that the non-cancer cells in the TME can confer chemoresistance and promote EMT associated with altered CSC phenotypes and matrix remodeling. Lastly, we demonstrated the potential of TME composition in predicting drug response. Overall, the model systems presented in this study provide platforms that can be used to better understand the role of CSCs and the TME in chemoresistance and poor clinical outcomes. This could ultimately lead to the development of novel therapies, enhanced clinical management, and improved clinical outcomes.

Date: Wednesday, July 21, 2021
Time: 9:00 AM
Zoom: https://umich.zoom.us/j/96111622879
Password: 326862
Chair: Dr. Geeta Mehta

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Presentation Mon, 12 Jul 2021 12:13:44 -0400 2021-07-21T09:00:00-04:00 2021-07-21T10:00:00-04:00 Off Campus Location Biomedical Engineering Presentation BME Event
BME Ph.D. Defense: Yuan Li (July 22, 2021 2:00pm) https://events.umich.edu/event/84452 84452-21624017@events.umich.edu Event Begins: Thursday, July 22, 2021 2:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults and has a poor prognosis with a median survival of approximately 14 months. Clinical standard assessment of therapy response and tumor progression is based upon post-contrast T1-weighted (T1W) and fluid-attenuated inversion recovery (FLAIR) T2-weighted (T2W) magnetic resonance images (MRI).  However, contrast enhancement observed on the post-contrast T1W MRI is affected not only by tumor growth but also effects of radiation, anti-angiogenesis drugs and chemotherapy, due to the fact that it represents blood-brain barrier disruption. Another problem is that abnormality on T2W FLAIR images is influenced by T2 changes of tumor cells as well as edema and necrosis that always co-exist within GBM. Diffusion weighted (DW) imaging has been proposed to overcome these limitations. Conventional DW images quantify apparent diffusion coefficient (ADC) with b-values between 0 and 1000 s/mm2 using a mono-exponential decay. One limitation is that co-existence of edema in clinical GBM elevates ADC.
 
In diffusion MRI, there are three dimensions of parameter spaces that we could explore in research —b value, diffusion time (t) and echo time (TE). Hence, we investigated and developed high order diffusion models in these three spaces and evaluated whether they could reveal more features of GBM.
 
In the b-value space, we investigated a microstructure model (MSM), in which modulation of diffusion gradient with cell size is considered, with high b-value diffusion images in the patients with GBM pre-radiation therapy (RT). We found apparent cell size (ARS), extracellular diffusion coefficient (Dex) and intracellular fractional volume (Vin) in tumor were significantly greater than ones in normal tissue and edema. In addition, we investigated diffusion kurtosis imaging (DKI) in GBM pre-RT and mid-RT, and found pre-RT mean kurtosis of the tumor could provide a predictive value of overall survival (OS) additional to clinical prognostic factors.
 
In the TE space, T2-Relaxation-Diffusion correlation experiments can be powerful in resolving water compartments with respect to their size and chemical composition, but the problem is ill-posed. We simplified the T2-Relaxation-Diffusion correlation to consider the T2 values and diffusion coefficients in a 2x2 fashion. We found that there were significant differences between fast and slow diffusion coefficients and between associated T2 values in tumor, cortex, deep GM, and edema. Multivariate Cox model showed the fractional volume of slow component (Vs) mid-RT may add a predictive value to clinical factors.
 
In diffusion time space, we applied three different diffusion times using pulsed diffusion gradients (PG) and oscillating gradients at frequencies of 30 Hz (OS30) and 50 Hz (OS50) using a prototype sequence. Using a random walk with barriers model, we estimated cell diameter, unrestricted diffusion coefficient (D0) at a short time limit, bulk diffusion coefficient (Dinf) at a long time limit, cell membrane permeability and effective restriction in the contrast-enhanced tumor. Those parameters provide microstructural information in the GBM and need to be further investigated and validated with pathology.
 
Previous studies have mainly investigated high order diffusion models in prostate cancer and xenograft tumor models, and only a few studies investigated GBM. The current knowledge about the relationship between model parameters and physiological/pathological features in GBM are still limited. Our research in GBM could lead to better imaging means for GBM diagnosis, tumor target definition for radiation therapy, and therapy response assessment.
 
Date: Thursday, July 22, 2021
Time: 2:00 PM
Zoom: https://umich.zoom.us/j/96213084276

Chair: Dr. Yue Cao

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Presentation Tue, 13 Jul 2021 13:47:02 -0400 2021-07-22T14:00:00-04:00 2021-07-22T15:00:00-04:00 Off Campus Location Biomedical Engineering Presentation BME Event
Improving Collaboration Between Drivers and Automated Vehicles with Trust Processing Methods (July 23, 2021 9:30am) https://events.umich.edu/event/84449 84449-21624011@events.umich.edu Event Begins: Friday, July 23, 2021 9:30am
Location: Off Campus Location
Organized By: Michigan Robotics

Trust has gained attention in the Human-Robot Interaction (HRI) field, as it is considered an antecedent of people's reliance on machines.
People rely on and use machines they trust and refrain from using machines they do not trust. The advances in robotic perception technologies open paths for the development of machines that can be aware of people's trust by observing humans' behaviors and identifying whether they are being trusted or not by those people. This dissertation explores the role and the intricacies of trust in the interactions of humans and robots, particularly Automated Vehicles (AVs).
Novel methods and models are proposed for perceiving and processing drivers' trust in AVs and for determining humans' natural trust or robots' artificial trust. Two high-level problems are addressed: the problem of avoiding or reducing miscalibrations of drivers' trust in AVs and the problem of how to use trust to dynamically allocate tasks between a human and a robot that collaborate.

A complete solution is proposed for the problem of avoiding or reducing trust miscalibrations, which combines methods for estimating and influencing drivers' trust through interactions with the AV. Three main contributions stem from that solution: the characterization of risk factors that affect drivers’ trust in AVs; the development of a new method for real-time trust estimation; and the development of a new method for trust calibration.

Although the development of a complete trust-based solution for the problem of dynamically allocating tasks between a human and a robot remains an open problem, this dissertation takes a step forward in that direction. The fourth contribution here proposed is the development of a unified bi-directional model for predicting natural and artificial trust. This trust model allows for the numerical computation of human's trust and robot's trust, which is represented by the probability of a given agent to successfully execute a given task. As a probability of success, trust can readily be used for the computation of expected rewards and costs for tasks to be executed by each possible agent and can guide decision-making algorithms based on the optimization of those rewards and costs.

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Lecture / Discussion Tue, 13 Jul 2021 08:09:21 -0400 2021-07-23T09:30:00-04:00 2021-07-23T11:30:00-04:00 Off Campus Location Michigan Robotics Lecture / Discussion Virtual autonomous vehicles make a left turn
BME PhD Defense: Emine Sumeyra Turali-Emre (August 2, 2021 1:00pm) https://events.umich.edu/event/84794 84794-21624994@events.umich.edu Event Begins: Monday, August 2, 2021 1:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Biomimetic nanoparticles (NPs) are bio-inspired inorganic nanoscale materials that replicate some biological nanostructures functionalities including self-assembly, catalysis, and enzyme inhibition. These functionalities are being investigated for and, in some cases, are being utilized in optics and electronics such as chemical sensors, superhydrophobic coatings, and antireflective surfaces. This thesis examines the utilization of biomimetic inorganic NPs for various problems in biomedical engineering.

Specifically, in the first part of this thesis, I address the problem on controversial explanations of the antibacterial and other biological activity of zinc oxide NPs that are frequently utilized in cosmetics, textiles, and biomedical fields. In the second part of the thesis, I explore the self-organization of NPs into biomimetic supraparticles (SPs) for nucleic acid delivery that can be exploited as drug delivery agents.

NPs have been used in the antimicrobial field for a long time; however, their antibacterial mechanism of action against different types of bacteria remains unclear and, in many cases, misinterpreted. Most of the studies on antimicrobial NPs suggest reactive oxygen species (ROS) formation, ion release, and membrane damage as the primary source of antibacterial activity. In Chapter 2, we show that the mechanism of antibacterial activity for Staphylococcus aureus is remarkably more complex than generating ROS or the release of Zn2+ ions and is based on formation of biomimetic complexes of NPs with proteins. Gene expression analysis demonstrated that ZnO-NPs significantly affect carbohydrate metabolism and cell energetics, where the uridine monophosphate (UMP) biosynthesis pathway is highly upregulated. In Chapter 3, we explore the ZnO-NP mode of entry into S. aureus and the cell metabolism. Here, we showed that NPs enter the cells within 5 minutes of exposure and induce minimal membrane damage. We note that cells do not depolarize until 60 min post-NPs exposure. Thereby, we highlight that membrane damage is not the primary mechanism of action but rather a downstream effect of ZnO-NPs exposure to bacterial cells. Taken together, causing minimal ROS production and significant changes in carbohydrate metabolism and bioenergetics along with cell entry without immediate membrane damage imply the biomimetic function of these NPs. Further investigation into the antimicrobial mechanisms of biomimetic NPs is essential for future clinical translation.

Over the past few decades, there has been considerable interest in developing nanoscale constructs as effective delivery tools for high molecular weight drugs. In chapter 4, I explore the self-assembly of NPs into compartmentalized SPs, which mimics the structure of a virus to deliver nucleic acid into cells. The time-dependent self-assembly mechanism reveals that these SPs are formed from nanocup intermediates. We found that this intermediate stage is essential for the utilization of SP compartments. Nucleic acid is added to the system at this stage before SP formation, and high encapsulation is achieved. Similar to virus infections, once cells uptake the SP, SP disassociates in endosomes and releases the cargo.

Overall, the work presented in this thesis investigates and highlights the strong potential of biomimetic inorganic NPs use in next-generation biomedical applications.

Date: Monday, August 2, 2021
TIme: 1:00PM
Zoom: https://umich.zoom.us/j/95043183845
Chair: Prof. Nicholas Kotov

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Presentation Wed, 28 Jul 2021 12:34:40 -0400 2021-08-02T13:00:00-04:00 2021-08-02T14:00:00-04:00 Off Campus Location Biomedical Engineering Presentation BME Event
BME PhD Defense: Daniel Clough (August 4, 2021 10:00am) https://events.umich.edu/event/84844 84844-21625176@events.umich.edu Event Begins: Wednesday, August 4, 2021 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

Type 1 diabetes is caused by the autoimmune destruction of insulin-producing β-cells, resulting in a chronic metabolic disorder typically treated with exogenous insulin. Even with the aid of advanced insulin pumps and real time feedback systems, blood glucose levels still deviate outside of the range maintained by native islets, which places the individual at risk for vascular complications and life-threatening hypoglycemic events. Cell replacement therapies have demonstrated the capacity to tightly control blood glucose levels. The wide adoption of cell replacement therapy is hindered by limited availability of donor islets, and the lack of effective methods to support the long-term function of these cells within a clinically accessible site. The results presented in this thesis address these limitations: through studying maturation of human pluripotent progenitor cell (hPPC) derived β cells within a transplantable biomaterial platform, and evaluating novel approaches to the implantation and support of these cells during their continued maturation in vivo.

First, I present a study that examined delivery of hPPC-derived pancreatic progenitors within microporous PLG scaffolds into the epididymal fat pad, the murine surrogate for the clinically relevant omental pouch. Kidney capsule injection, the site most commonly utilized to test stem cell-derived β cell function in murine models, was the comparison condition. We observed that the microporous scaffolds supported cell engraftment, however the levels of circulating C-peptide were lower when compared to the kidney capsule condition. The scaffolds were subsequently modified to provide sustained release of exendin-4, which led to significantly increased C-peptide production. Image analysis revealed that exendin-4 releasing scaffolds enhanced the proportion of pancreatic progenitors that matured to monohormonal insulin producing cells.

Next I present my findings from studying how hPPC-derived β cells mature and function within three transplantation sites: the i) scaffold delivery into the epididymal fat pad, ii) scaffold delivery into the subcutaneous space, and iii) the kidney capsule injection (control). Additionally, we investigated the impact of blood glucose levels on maturation of the hPPC-derived β cells by transplanting mice with pre- or post-engraftment diabetes induction. Hyperglycemia was ameliorated in the cohorts of mice that received scaffolds into the epididymal fat pad, following a period of in vivo maturation. The function of these cells was demonstrated by the reduction in blood glucose levels, healthy increase in weight, therapeutic levels of circulating human insulin, and healthy responses to glucose challenge tests. The function from the epididymal fat pad was superior to the subcutaneous space and was observed to be comparable to the kidney capsule. No differences were observed in graft function between the cohorts whose grafts matured in a diabetic or non-diabetic environment, yet several differences in gene expression were observed.

Many of the current differentiation protocols culture the cells above a feeder layer in monolayer, or in suspension within a bioreactor. Typically, these protocols require the disruption of the cell niche during key differentiation stages or pre-transplantation handling. Biomaterial scaffolds maintain the integrity of cell-to-cell and cell-to-matrix connections by providing both a space for cell niche development as well as a vehicle for transplantation into the body. Herein, I present results from testing the developmental stage in which progenitors are seeded into the 3D niche, and two differentiation strategies prior to seeding: monolayer and suspension culture. Maturation was characterized via gene expression analysis, glucose stimulated insulin secretion assay, and nondestructive microscopy utilizing a sfGFP-C-peptide cell line that reports C-peptide production and secretion. We observed that seeding clusters during the key transition phase from pancreatic progenitor to pancreatic endocrine enhanced commitment to the final beta cell fate.

This work enhances our understanding of hPPC-derived beta cell manufacturing within scaffolds, and delivery to an extrahepatic site to achieve normoglycemic blood glucose levels.

Date: Wednesday, August 4, 2021
Time: 10:00 AM
Zoom: https://umich.zoom.us/j/98009467275
Password: betacell
Chair: Dr. Lonnie Shea

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Presentation Mon, 02 Aug 2021 10:58:53 -0400 2021-08-04T10:00:00-04:00 2021-08-04T11:00:00-04:00 Off Campus Location Biomedical Engineering Presentation BME Event
UROP Summer Research Symposium (August 4, 2021 3:00pm) https://events.umich.edu/event/84255 84255-21620819@events.umich.edu Event Begins: Wednesday, August 4, 2021 3:00pm
Location: Off Campus Location
Organized By: UROP - Undergraduate Research Opportunity Program

Live via Zoom: https://myumi.ch/lx3Y7 on August 4th from 3:00pm - 6:30pm ET
Learn more about our presenters and their research at:
https://courses.lsa.umich.edu/urop-symposium/

The Undergraduate Research Opportunity Program’s Annual Research Symposium is the culminating event for all students participating in UROP Programs. The event celebrates the partnerships created between students and research mentors, and serves as a conference where students present their research project and learn about the research their fellow UROP students have worked on throughout the program.

The Symposium will showcase presentations from 5 research fellowships
- Biomedical and Life Sciences Summer Fellowship
- Community College Summer Fellowship Program
- Engineering Summer Research Fellowship
- Intel Semiconductor Research Corporation Summer Fellowship
- Women and Gender Summer Fellowship Program

Live via Zoom on August 4th from 3:00pm - 6:30pm ET

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Conference / Symposium Tue, 27 Jul 2021 15:41:21 -0400 2021-08-04T15:00:00-04:00 2021-08-04T18:30:00-04:00 Off Campus Location UROP - Undergraduate Research Opportunity Program Conference / Symposium UROP Summer Symposium August 4th
BME PhD Defense: Dorsa Haji Ghaffari (August 5, 2021 11:00am) https://events.umich.edu/event/84795 84795-21624995@events.umich.edu Event Begins: Thursday, August 5, 2021 11:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

Retinal prostheses have restored a sense of vision in patients blinded by photoreceptor degeneration. These electronic implants operate by electrically stimulating the remaining retinal cells. While retinal prosthesis users report improvements in light perception and performing basic visual tasks, their ability to perceive shapes and letters remains limited. Investigating stimulation strategies to reduce perceptual thresholds and create focal, non-overlapping phosphenes will increase the resolution of retinal prostheses and improve the overall patient outcomes. In this thesis I explore two main strategies for electrode-specific optimization of stimulation parameters: 1) a novel pulse paradigm for threshold reduction, and 2) an automated closed-loop method for adjusting stimulation parameters to create a focal retinal activation area.

I combined human subject testing and computational modeling to investigate the effect of waveform asymmetry on perception shapes and thresholds with epiretinal stimulation. Threshold measurement and phosphene shape analysis was performed on four Argus II users. A computational model of a retinal ganglion cell (RGC) was created in the NEURON simulation environment to allow for a more thorough parameter testing and to gain insight into the biophysical mechanisms. Our human subject results suggest that asymmetric waveforms could increase perception probabilities compared to a standard symmetric pulse, and this effect can be intensified by addition of an interphase gap (IPG). Our in silico model predicts that the most effective pulse for threshold reduction is asymmetric anodic-first stimulation with small duration ratios (≤ 5) and long IPGs (≥ 2 ms). Phosphene shape analysis revealed no significant difference in percept elongation with different pulse types. Average phosphene area was larger with asymmetric anodic-first stimulation compared to other pulse types.

Prosthetic vision quality is highly dependent on the capability to precisely activate target neurons and avoid off-target activation. However, studies show elongated and inconsistent responses to single electrode stimulation, indicating unintended stimulation of off-target neurons and electrode-specific activation patterns. While tuning stimulation parameters can transform the spatial RGC activity, a manual search for optimal parameters can be time consuming and tiring for patients. I developed a process for automatic optimization of stimulation parameters in silico, which involved training neural networks for quantifying the relationship between pulse parameters and spatial response descriptors, and a closed-loop algorithm to search for optimal parameters. Using this process, I was able to guide the parameter search effectively and converge to an optimal response within a few iterations.

Finally, I presented a process for automatic optimization of stimulation parameters in vitro using calcium imaging in mouse retina. This process involved training neural networks at each iteration based on a few images, using an interior point algorithm to find the optimal parameters, and classifying the resulting calcium images with a CNN trained on previous data. Our results indicate that we can converge to optimal stimulation parameters that create focal RGC activity by sampling less than 1/3 of the parameter space. This approach can shorten the exploration time significantly compared to a manual search, especially when the parameter space is large. Findings of this project could lead to the development of a clinically applicable system for electrode-specific optimization of stimulation protocol, improving the overall outcome of artificial vision.

Date: Thursday, August 5, 2021
Time: 11:00 AM
Zoom: https://umich.zoom.us/j/93552322970
Chair: Dr. James Weiland

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Presentation Wed, 28 Jul 2021 12:42:01 -0400 2021-08-05T11:00:00-04:00 2021-08-05T12:00:00-04:00 Off Campus Location Biomedical Engineering Presentation BME Event
Engineer Your Happiness (August 5, 2021 12:00pm) https://events.umich.edu/event/84434 84434-21623980@events.umich.edu Event Begins: Thursday, August 5, 2021 12:00pm
Location: Off Campus Location
Organized By: Engineering Office of Student Affairs

Presenters: Kayla Douglas, LLMSW and Nidaa Shaikh, PsyD

Description: "This experiential workshop will use the principles of positive psychology and CoE graduate students' unique strengths, to empower them, in their pursuit to create a life of meaning, resilience, and fulfillment.”

Please register by 8/2, at https://forms.gle/9kwQYwWg1MCcZrUo6

Sponsored by the CoE Office of Student Affairs. Questions may be sent to ajrose@umich.edu.

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Workshop / Seminar Mon, 12 Jul 2021 09:14:27 -0400 2021-08-05T12:00:00-04:00 2021-08-05T13:30:00-04:00 Off Campus Location Engineering Office of Student Affairs Workshop / Seminar
BME PhD Defense: Ahmet Emre (August 9, 2021 2:00pm) https://events.umich.edu/event/84859 84859-21625204@events.umich.edu Event Begins: Monday, August 9, 2021 2:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Energy storage is an integral part of life. Living creatures have developed a distributed and structural energy storage system to survive under various and sometimes extreme conditions. Similarly, energy storage is critical for modern life to power from small biomedical instruments to large aircraft. There are still several challenges against efficient and safe energy storage utilization due to the mechanical, chemical, and physical limitations of existing materials. Inspired by biological structures, we present multifunctional nanocomposites from aramid nanofibers (ANF), a nanoscale version of Kevlar, to address the safety and efficiency of various battery chemistries and enable structural energy storage to increase energy density. High mechanical properties of ANF suppress dendrite formation, and tunability with different copolymers and fabrication methods allow ANF-based nanocomposites to meet specific needs of different battery chemistries.

In the first part of this thesis, we engineered biomimetic solid electrolyte from ANF and polyethylene oxide for zinc batteries inspired by the cartilage structure. These strong nanocomposites can block stiff zinc dendrite and prevent short circuits over cycles. Resilience to plastic deformation and damage while having no leaking fluids or cracks is essential for the safety of, for instance, electrical vehicles employing such batteries. These load-bearing batteries can be used as a structural component and increase energy density by simply avoiding inactive parts. As a proof of concept, we utilized this battery on a commercial drone as an auxiliary energy storage unit to extend flight endurance by about 20%.

The second part of the thesis addresses a specific polysulfide shuttle problem in lithium-sulfur batteries utilizing bioinspired ANF nanocomposites. Mimicking ion channels on the cell membrane, we engineered biomimetic nanochannels (1nm diameter) for selectively allowing lithium-ion passage while physically blocking lithium polysulfide species (>2nm) on the cathode side. Selective ion transport through nanochannels is also modeled by finite element analysis, COMSOL. These ion channels allow us to reach >3500 cycles.

In addition to previous solid and liquid electrolyte systems, here in the last part of the thesis, we present a tunable quasi-solid polymer electrolyte to take advantage of both electrolyte features while minimizing their individual risks and drawbacks. Similar to the kidney filtration system, specifically the glomerular basement membrane, this gel electrolyte filters ions depending on their size and charge. Selective permeability and regulated ion transport provide safe and stable charge/discharge cycles. High mechanical properties keep functionality under extreme conditions, including high temperature and nail penetration. We integrated pouch cells in various prototypes to show practical utilization of our structural batteries, including health monitoring devices, robotic prosthetics, and electric vehicles.

Taken together, mimicking structural and functional properties of multifunctional biological materials, i.e., cartilage, we present a novel multifunctional nanocomposite system that can be tailored to the specific needs of numerous structural energy storage applications.

Date: Monday, August 9, 2021
Time: 2:00 PM
Zoom: https://umich.zoom.us/j/92570283886
Chair: Prof. Nicholas Kotov

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Presentation Mon, 02 Aug 2021 12:53:44 -0400 2021-08-09T14:00:00-04:00 2021-08-09T15:00:00-04:00 Off Campus Location Biomedical Engineering Presentation BME Event
BME PhD Defense: Steven Cutlip (August 9, 2021 2:00pm) https://events.umich.edu/event/84858 84858-21625203@events.umich.edu Event Begins: Monday, August 9, 2021 2:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

For the sensorimotor system to complete motor tasks it controls the body, it controls objects that the sensorimotor system acts upon within the environment, and it anticipates future states of the environment. The sensorimotor system is known to adapt and improve in performance with practice in response to predictable phenomena. The literature explains motor adaptation and performance improvement in terms of models, called internal models, of future loads. The theory of internal models has been investigated in the neuroscience and human motor behavior communities, where electrophysiological data and motor performance experiments have yielded rich data in support of the role of predictive modeling.

Internal models can be divided into two types: internal models of the plant and internal models of exogenous processes. While internal models of the plant have a rich history and have been studied extensively, literature on internal models of exogenous processes is less developed. This dissertation introduces the Internal Model Principle (IMP) as a tool for modeling internal models of exogenous processes. This dissertation further extends the usefulness of the IMP for modeling human motor control by extending the model to handle sensorimotor tasks that feature signal blanking.

Haptic feedback can be considered as an exogenous signal (a disturbance) whose features can be predicted because they are produced by the plant under control. Haptic feedback is an information signal providing the receiver feedback about the state of the system. However, haptic feedback is also a power signal; sufficient force due to haptic feedback can backdrive the biomechanics of a participant. In this dissertation these topics are explored in two studies, one in the context of driving oscillations in a spring-mass system and the other in the context of shared control design for semi-autonomous vehicles.

Date: Monday, August 9, 2021
Time: 2:00 PM
Zoom: https://umich.zoom.us/j/97211413457
Chair: Brent Gillespie

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Presentation Mon, 02 Aug 2021 12:46:34 -0400 2021-08-09T14:00:00-04:00 2021-08-09T15:00:00-04:00 Off Campus Location Biomedical Engineering Presentation BME Event
BME Master's Defense: Hind AlYahya (August 10, 2021 1:00pm) https://events.umich.edu/event/84890 84890-21625248@events.umich.edu Event Begins: Tuesday, August 10, 2021 1:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Peripheral arterial disease (PAD) is a disorder that restricts the blood flow in arteries that carry blood to the limbs; it frequently affects the legs. This restriction occurs due to severe atherosclerosis (stenosis), an accumulation of fatty materials in the vessel lumen. Stents are used to manage this disease. However, in-stent restenosis can occur at an unpredictable time, leading to emergency hospitalization or death.

The wireless magnetoelastic monitoring system showed its potential to detect restenosis. The main components of this system are a miniaturized wireless sensor integrated into the stent and a bias magnet. The purpose of using a magnet is to provide a uniform magnetic field for the sensor to operate. This work aims to improve the design of the system components to be compatible with the commercial self-expanding vascular stents. The magnetoelastic sensor was designed to fit with a conventional self-expanding stent (e.g., Innova™ from Boston Scientific Corp.) used to treat superficial femoral artery lesions. It is designed to be a single layer of MetglasTM 2826MB (12 mm x 0.85 mm x 29 um). However, the sensor could be damaged during the stent deployment. As a result, it is necessary to encapsulate the sensor. A polymeric package was designed to house the sensor and the biasing magnet. The package is attached to the stent structure by two helical wires made of nitinol material. The biasing magnet is a strip of ArnokromeTM 5 (13.2 mm x 0.85 mm x 50 um). FEA tool was used to evaluate the performance of the sensor and the magnetic strip. The results showed that the sensor vibrates at 149 kHz. The magnetic field distribution confirmed that the ArnokromeTM 5 generates a sufficient magnetic field strength for the sensor to operate. This work also covers an analytical analysis of using electromagnetic coils to provide DC bias for the system. However, the results showed that the heat dissipated from the coils could be hard to manage.

If implanting this package is successful *in vivo* experiments, the detection of restenosis will be achieved in an earlier stage, saving the patient from undergoing another surgery. Therefore, the wireless monitoring system can reduce emergency surgeries and mortality that results from PAD, leading to healthier patients and a lower burden on hospital resources.

Date: Tuesday, August 10, 2021
Time: 1:00 PM
Zoom: https://umich.zoom.us/j/99281419966
Chair: Prof. Yogesh B. Gianchandani

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Presentation Tue, 03 Aug 2021 10:09:05 -0400 2021-08-10T13:00:00-04:00 2021-08-10T14:00:00-04:00 Off Campus Location Biomedical Engineering Presentation BME Event
SWE x Disclosed Panel "How to make yourself stand out?" (September 1, 2021 7:00pm) https://events.umich.edu/event/86185 86185-21631883@events.umich.edu Event Begins: Wednesday, September 1, 2021 7:00pm
Location: Off Campus Location
Organized By: Society of Women Engineers

Worried about how to stand out as an applicant at Career Fair when you haven't had any experience? Want to hear advice from managers at Nissan and LinkedIn? Then come to our panel, Wednesday, September 8th at 7 pm EST!! Fill out the form to submit questions and receive notes after the event! Please email Gabrielle & Eva at swe.car.directors@umich.edu if you have any questions!

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Careers / Jobs Wed, 01 Sep 2021 19:51:56 -0400 2021-09-01T19:00:00-04:00 2021-09-01T20:00:00-04:00 Off Campus Location Society of Women Engineers Careers / Jobs
Department of Computational Medicine & Bioinformatics || Weekly Seminar Series (September 8, 2021 4:00pm) https://events.umich.edu/event/86237 86237-21632210@events.umich.edu Event Begins: Wednesday, September 8, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

Structural variants (SVs) are a source of pathogenic variants in a clinical referral population, however, they are often under-reported due to technical limitations of detection and difficulty with clinical interpretation. For example, mobile element insertions (MEIs) are estimated to lead to a positive finding in 1 out of 1000 rare genetic disease cases, yet the numbers are far lower in clinical diagnostic laboratories. Targeted NGS with short insert size libraries, unlike genome sequencing, will have very few discordant read pairs to indicate the presence of an SV. We, therefore, developed an SV detection tool called SCRAMble (Soft Clipped Read Alignment Mapper) to identify SV breakpoints in targeted NGS.

We applied SCRAMble to a prospective clinical referral cohort for exome sequencing to identify deletions and MEIs. We also applied SCRAMble to a hereditary cancer panel assay for the identification of a large inversion involving the MSH2 gene that causes Lynch syndrome. Adding breakpoint detection to clinical targeted sequencing identifies positive findings which were missed by prior testing and by other variant callers. Detecting breakpoints allows for more precise interpretation and for more targeted confirmation assays. By applying SV breakpoint detection, we are able to diagnose ~0.3% more cases. While this is a modest gain in diagnostic yield, for the patients and families involved, a positive diagnosis, even after prior testing, can have a meaningful impact on their lives.

Zoom link: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Thu, 02 Sep 2021 14:28:18 -0400 2021-09-08T16:00:00-04:00 2021-09-08T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual Rebecca Torene, Associate Director of Genomics Research | Data Science at GeneDx
engIN 2021 (September 8, 2021 5:00pm) https://events.umich.edu/event/84463 84463-21624040@events.umich.edu Event Begins: Wednesday, September 8, 2021 5:00pm
Location: The Grove
Organized By: Michigan Engineering

It’s a carnival vibe with tasty treats, lawn games and interactive inflatables. Plus, you get your official engIN21 tee shirt (probably the coolest free tee on campus).

Mingle with new friends and meet the people who will help you succeed at Michigan.

Wednesday, Sept 8
5-6:30 PM EST
North Campus Diag/Grove (by the bell tower)
Michigan Engineering will email students their RSVP link. REGISTRATION IS REQUIRED.

Forever GO BLUE - starts now!

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Social / Informal Gathering Wed, 14 Jul 2021 09:39:44 -0400 2021-09-08T17:00:00-04:00 2021-09-08T18:30:00-04:00 The Grove Michigan Engineering Social / Informal Gathering Michigan Engineering first-year students attend engineering 2019 on the Eda U. Gerstacker Grove on North Campus of the University of Michigan
engIN 2021 (September 8, 2021 6:30pm) https://events.umich.edu/event/84463 84463-21624041@events.umich.edu Event Begins: Wednesday, September 8, 2021 6:30pm
Location: The Grove
Organized By: Michigan Engineering

It’s a carnival vibe with tasty treats, lawn games and interactive inflatables. Plus, you get your official engIN21 tee shirt (probably the coolest free tee on campus).

Mingle with new friends and meet the people who will help you succeed at Michigan.

Wednesday, Sept 8
5-6:30 PM EST
North Campus Diag/Grove (by the bell tower)
Michigan Engineering will email students their RSVP link. REGISTRATION IS REQUIRED.

Forever GO BLUE - starts now!

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Social / Informal Gathering Wed, 14 Jul 2021 09:39:44 -0400 2021-09-08T18:30:00-04:00 2021-09-08T20:00:00-04:00 The Grove Michigan Engineering Social / Informal Gathering Michigan Engineering first-year students attend engineering 2019 on the Eda U. Gerstacker Grove on North Campus of the University of Michigan
Ice Cream + Info (September 9, 2021 2:00pm) https://events.umich.edu/event/85986 85986-21630646@events.umich.edu Event Begins: Thursday, September 9, 2021 2:00pm
Location: The Grove
Organized By: Multidisciplinary Design Program

Join Multidisciplinary Design Program + ArtsEngine staff and project sponsor JPMorgan Chase for ice cream and information about our upcoming recruitment for 2022 partner sponsored, faculty research, and FEAST projects!

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Reception / Open House Mon, 30 Aug 2021 16:04:47 -0400 2021-09-09T14:00:00-04:00 2021-09-09T16:00:00-04:00 The Grove Multidisciplinary Design Program Reception / Open House Bowl of ice cream that says Free Ice Cream! above it and Sponsored By JPMorgan Chase & Co underneath
BME 500 Seminar: A machine learning-based predictive model of genome-wide binding of the Aryl Hydrocarbon Receptor (September 9, 2021 4:00pm) https://events.umich.edu/event/86318 86318-21632715@events.umich.edu Event Begins: Thursday, September 9, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Abstract:

The Aryl Hydrocarbon Receptor (AhR) is an inducible transcription factor (TF) whose ligands include the potent environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). TCDD-mediated toxicity is believed to occur through activation of AhR and its binding to the 5'-GCGTG-3' DNA motif, referred to as the Dioxin Response Element (DRE). However, AhR binding in intact human cells is highly dynamic and tissue-specific. Approximately 50% of all experimentally verified AhR binding sites do not contain a DRE, and a great number of otherwise accessible DREs are not bound by AhR. Identification of the determinants of tissue-specific AhR binding is crucial for understanding downstream gene regulatory effects and potential adverse health outcomes of TCDD exposure, such as liver toxicity and immune suppression. We applied XGBoost, a supervised machine learning architecture, to predict genome-wide AhR binding as a function of DNA sequences immediately flanking the DRE, and local chromatin context features such as DNase-seq, histone modifications, and TF ChIP-Seq signals, as well as DRE proximity to gene promoters. We predicted binding of induced AhR in MCF-7 breast cancer cells, human hepatocytes, and the human lymphoblastoid cell line GM17212, as well as constitutive AhR binding in HepG2 cells. Our results demonstrate highly accurate and robust models of within-tissue binding, with several specific TFs and HMs identified as predictive of AhR binding within and across tissues. Additionally, we show that tissue-specific AhR binding is driven by a complex interplay of DNA flanking sequence and local chromatin context.

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Lecture / Discussion Fri, 03 Sep 2021 12:47:39 -0400 2021-09-09T16:00:00-04:00 2021-09-09T17:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Event
Ford Motor Company Robotics Building Dedication Ceremony (September 10, 2021 3:00pm) https://events.umich.edu/event/86396 86396-21634173@events.umich.edu Event Begins: Friday, September 10, 2021 3:00pm
Location: Off Campus Location
Organized By: Michigan Robotics

Please join us as we celebrate the Ford Motor Company Robotics Building Dedication at the University of Michigan College of Engineering.

Friday, 10 September 2021
Program to begin at 3:00 PM

Michigan Robotics is embarking on several efforts to build an inclusive robotics program from the ground up, which aims to train those in the next field of engineering with concepts and values that will help enable all of humanity.

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Ceremony / Service Tue, 07 Sep 2021 08:42:44 -0400 2021-09-10T15:00:00-04:00 2021-09-10T15:45:00-04:00 Off Campus Location Michigan Robotics Ceremony / Service Robotics building at night
NERS Fall 2021 Colloquia (September 10, 2021 4:00pm) https://events.umich.edu/event/84088 84088-21619939@events.umich.edu Event Begins: Friday, September 10, 2021 4:00pm
Location: Cooley Building
Organized By: Nuclear Engineering and Radiological Sciences

FALL 2021 SCHEDULE
Colloquia are at 4pm on Fridays in the White Auditorium (G906 Cooley Building) unless otherwise noted.

SEPTEMBER 10
Ken Powell, Aerospace Engineering, U-M
Increasing Diversity and Inclusion in Academic Departments

SEPTEMBER 17
Todd Allen and Kristine Svinicki, Nuclear Engineering & Radiological Sciences, U-M
Department Welcome

SEPTEMBER 24
Steven Aumeier, Idaho National Laboratory (1:30pm in the GM Room)
Advanced Clean Energy and Production – Accelerating Energy Transitions Through Adaptive Clean Energy and Industrial Capacity

SEPTEMBER 24
Shikha Prasad, Nuclear Engineering, Texas A&M University
Next-Generation Portable Antineutrino Detectors Using Semiconductors

OCTOBER 1
Harsh Desai, Zeno Power Systems
Enabling Space Missions with Radioisotope Power Systems

OCTOBER 22
Assel Aitkaliyeva, University of Florida
Constituent Redistribution in U-Pu-Zr Fuels and its Dependence on Zr Content

OCTOBER 29
Leslie Dewan, Criticality Capital
Nuclear Entrepreneurship: The Good, The Bad, and The Ugly

NOVEMBER 5
Tom Wellock, Nuclear Regulatory Commission
Safe Enough? A History of Nuclear Power and Accident Risk

NOVEMBER 12
Christine King, Idaho National Laboratory, Gateway for Accelerated Innovation in Nuclear
Changing the Establishment from Within: How Small Teams and Initiatives Can Be Incredibly Impactful

NOVEMBER 19
Shannon Bragg-Sitton, Idaho National Laboratory
TBD (topic: integrated energy systems)

DECEMBER 3
Kelsa Palomares, NASA Marshall
Reactor Materials Challenges to Enable Space Nuclear Propulsion

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Workshop / Seminar Mon, 20 Sep 2021 12:35:00 -0400 2021-09-10T16:00:00-04:00 2021-09-10T17:00:00-04:00 Cooley Building Nuclear Engineering and Radiological Sciences Workshop / Seminar Colloquia
Kayaking with GoSTEM (September 11, 2021 1:00pm) https://events.umich.edu/event/85710 85710-21628306@events.umich.edu Event Begins: Saturday, September 11, 2021 1:00pm
Location: Off Campus Location
Organized By: Grads Out in STEM

Join Grads Out in STEM for an afternoon of kayaking at Gallup Park Livery on Sat, Sept 11, 1-3 pm. $5 registration. Open to all grad students and post docs in STEM departments and CoE at UMich. Spots are limited. Registration opens 9/1 at 8 pm. Link to register at https://sites.google.com/umich.edu/gostem/home. Sponsored by the Office of Student Affairs.

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Social / Informal Gathering Thu, 26 Aug 2021 17:26:41 -0400 2021-09-11T13:00:00-04:00 2021-09-11T15:00:00-04:00 Off Campus Location Grads Out in STEM Social / Informal Gathering An orange kayak in dark water approaching dark mountains with text about the event, given in description as well.
Graduate Career Fair Reception, hosted by GradSWE (September 12, 2021 2:00pm) https://events.umich.edu/event/85909 85909-21630296@events.umich.edu Event Begins: Sunday, September 12, 2021 2:00pm
Location: Off Campus Location
Organized By: Graduate Society of Women Engineers

Are you a grad student looking to jumpstart your career? If you plan to participate in the upcoming Fall SWE/TBP Career Fair, consider joining us the Sunday prior at our annual Graduate Career Fair Reception hosted by GradSWE! This is an informal event that will allow you to network with recruiters looking specifically for MS/PhD students. The reception will be held Sunday 9/12 2-5 PM ET. A list of participating companies will be published closer to the event. During the session, students may freely join breakout rooms with their companies of interest. No resumes will be accepted at the event. Due to COVID19, we will be holding this session virtually on Zoom. Please RSVP to get access to the link! The current list of companies, agenda for the event, and more information about them can be found in the link labeled "Company List"

RSVP is required.
Contact: Shannon Clancy at sclancy@umich.edu

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Careers / Jobs Thu, 09 Sep 2021 17:05:26 -0400 2021-09-12T14:00:00-04:00 2021-09-12T17:00:00-04:00 Off Campus Location Graduate Society of Women Engineers Careers / Jobs
RNA Innovation Seminar (September 13, 2021 4:00pm) https://events.umich.edu/event/86155 86155-21631746@events.umich.edu Event Begins: Monday, September 13, 2021 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

"Recent improvements in modeling and design of RNA-only structures"

ABSTRACT: The discovery and design of biologically important RNA molecules is outpacing three-structural characterization. I'll describe results from my and Wah Chiu's groups that demonstrate that cryo-electron microscopy can resolve maps of several kinds of RNA-only systems. These maps enable subnanometer-resolution 3D coordinate estimation when complemented with multidimensional chemical mapping and Rosetta DRRAFTER computational modeling. If time allows, I'll describe work from the Eterna project to stabilize mRNA molecules to help accelerate worldwide COVID immunization.

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Lecture / Discussion Thu, 02 Sep 2021 12:54:16 -0400 2021-09-13T16:00:00-04:00 2021-09-13T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Rhiju Das, Stanford University
How Safe Is Safe Enough: Analyzing Hazards and Risks in the Real World to Inform Decision Making (September 13, 2021 4:30pm) https://events.umich.edu/event/86451 86451-21634340@events.umich.edu Event Begins: Monday, September 13, 2021 4:30pm
Location: Industrial and Operations Engineering Building
Organized By: Center for Healthcare Engineering & Patient Safety (CHEPS)

No endeavor/decision is without risk. Despite the best of intentions decisions that lead to undesired outcomes (financial, human, political, reputation), many times catastrophic, occur during the operation of complex systems. Unfortunately (tragically), it is also common that the parties that made these decisions or were impacted by these undesired outcomes viewed them as unexpected when they occurred. Even worse, because the outcomes were unexpected there was generally little or no preparation for their occurrence further magnifying the extent and the impact to the individuals, organizations, and society as a whole. Since no system can be reasonably expected to perform flawlessly and with perfection all of the time, the hazards that can cause undesired outcomes should be proactively identified and their associated risks should be either mitigated or the residual risk after mitigation should be accepted by those entities responsible for the system in question. Unfortunately, history shows us that this is often not the case and arises from myriad reasons. Engineering risk analysis provides a systematic, holistic approach for addressing risks associated with complex technical systems. The irony is that few engineers are ever introduced to or learn how to apply this knowledge in their professional activities. A discussion of approaches, including real world examples, to proactively identify hazards, their associated risks, and potential mitigation approaches that can mitigate the likelihood that an unacceptable outcome will occur.

Dr. James P. Bagian is a co-founder and the Executive Director of the Center for Risk Analysis Informed Decision Engineering (RAIDE) and is a Professor in the Departments of Industrial and Operations Engineering, Aerospace Engineering, and the Department of Anesthesiology at the University of Michigan. He has extensive experience in the fields of human factors, aviation, patient and transportation safety, and risk assessment and management. Dr. Bagian was also the founding Director of the Center for Healthcare Engineering and Patient Safety at the University of Michigan. Previously he served as the first and founding director of the Department of Veterans Affairs National (VA) Center for Patient Safety and was the VA’s first Chief Patient Safety Officer where he developed numerous systems and risk based tools and programs that have been adopted nationally and internationally. A NASA astronaut, he is a veteran of two Space Shuttle missions and has also served as the Chief Flight Surgeon and Medical Consultant for the Space Shuttle Columbia Accident Investigation Board as well as being an investigator for the Space Shuttle Challenger mishap investigation. He was elected to two terms as the Chair of the Joint Commission’s Patient Safety Advisory Group and was a member of NASA’s Aerospace Safety Advisory Panel from 2006-2018. Bagian holds a B.S. degree in mechanical engineering from Drexel University and a doctorate in medicine from Thomas Jefferson University. He is a Fellow of the Aerospace Medical Association and is an elected member of the National Academy of Engineering and the National Academy of Medicine.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach. For the Zoom link and password and to be added to the weekly e-mail for the series, please RSVP. For additional questions, contact CHEPSseminar@umich.edu. Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Tue, 07 Sep 2021 16:17:10 -0400 2021-09-13T16:30:00-04:00 2021-09-13T17:30:00-04:00 Industrial and Operations Engineering Building Center for Healthcare Engineering & Patient Safety (CHEPS) Lecture / Discussion James P. Bagian, MD, PE
Optiver Information Session (September 13, 2021 5:00pm) https://events.umich.edu/event/86803 86803-21636603@events.umich.edu Event Begins: Monday, September 13, 2021 5:00pm
Location: Off Campus Location
Organized By: Tau Beta Pi

Optiver is a global proprietary market maker, trading on all major financial markets around the world. During this event you will learn the ins-and-outs of Optiver, and how your unique skillsets can contribute to our technical teams. The event will end with an insider look into the Optiver interview process and an interactive Q&A!

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Careers / Jobs Sun, 12 Sep 2021 17:48:20 -0400 2021-09-13T17:00:00-04:00 2021-09-13T18:00:00-04:00 Off Campus Location Tau Beta Pi Careers / Jobs Optiver
Tauber Leadership Speaker Series | Sam McCleery (September 14, 2021 7:00pm) https://events.umich.edu/event/86955 86955-21637626@events.umich.edu Event Begins: Tuesday, September 14, 2021 7:00pm
Location: Off Campus Location
Organized By: Tauber Institute for Global Operations

Sam McCleery is an Emmy award winning executive who has been in the forefront of innovation for several popular sports brands. He founded a company that pioneered the First-and-Ten Yellow Line in football and has worked for Prince Tennis, Cablevision, adidas, ESPN and most recently at Under Armour. At Under Armour he ran the Open Innovation teams and later served in Corporate Development.

Sam is an industry-recognized and proven executive specializing in forming product, markets and businesses around new and emerging technologies. He excels at bridging the gap between technology and business, providing unique management expertise when developing product strategies and go-to-market plans.

Sam will present 'ESPN as an Innovation,' which focuses on the founding of an All-American brand and delivers a case study on how it became a part of our entertainment, sports and social culture.

FOR WEBINAR LINK: https://myumi.ch/R5Y1D

CAN'T ATTEND? In the event that this Tauber Leadership Speaker Series is recorded, it would be added to the Leadership Speaker Series post-session.

UPCOMING MEETINGS: Check the Tauber Leadership Speaker Series for upcoming events: http://myumi.ch/VPx4z

HOSTED BY: Tauber Institute for Global Operations. For questions about this event, please visit tauber.umich.edu.

The Tauber Leadership Speaker Series is a student-organized initiative to bring in top leaders from industry to the University of Michigan. These high-level executives are invited to share insights on their own careers, the qualities needed in today's global economy for strong leadership, and tangible steps to achieve excellence in one's own career path.

For more information:

Email TLSS organizer dianak@umich.edu
Visit the visit tauber.umich.edu
Follow Tauber on Facebook, Twitter, and Flickr

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Presentation Tue, 14 Sep 2021 17:00:35 -0400 2021-09-14T19:00:00-04:00 2021-09-14T21:00:00-04:00 Off Campus Location Tauber Institute for Global Operations Presentation Sam McCleery
Nuclear Innovation, Decarbonization, and Environmental Justice (September 15, 2021 10:30am) https://events.umich.edu/event/86205 86205-21632178@events.umich.edu Event Begins: Wednesday, September 15, 2021 10:30am
Location: Off Campus Location
Organized By: Nuclear Engineering and Radiological Sciences

The nuclear energy sector finds itself at a crossroads— in the US as well as globally. Environmentalists and policymakers are increasingly calling for nuclear energy to make substantial contributions to our future low carbon energy systems, even as nuclear energy remains at the center of polarizing debates about nuclear waste, safety, proliferation, and inequitable treatment of communities of color displaced or harmed by nuclear facilities. Reimagining a new future for the nuclear sector requires repairing and building trust with society and a responsible stewardship of nuclear technologies and nuclear wastes that centers principles of environmental justice. Through this conversation, we hope to begin to reimagine the technological, institutional, intellectual, and ethical foundations of the nuclear energy sector.

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Workshop / Seminar Thu, 02 Sep 2021 12:06:18 -0400 2021-09-15T10:30:00-04:00 2021-09-15T13:00:00-04:00 Off Campus Location Nuclear Engineering and Radiological Sciences Workshop / Seminar image card
The Future of Mobility & Connected Transportation with Smart Infrastructure (September 15, 2021 2:00pm) https://events.umich.edu/event/85754 85754-21628677@events.umich.edu Event Begins: Wednesday, September 15, 2021 2:00pm
Location: Off Campus Location
Organized By: Center for Connected and Automated Transportation

Cavnue was founded with the vision of bringing mobility to everyone. In order to do that, we must expand the autonomous driving capabilities of vehicles beyond where they are today. We believe that simplifying road designs and connecting vehicles to the infrastructure will be an important element in bringing autonomous technology to scale and making safer roads for everyone.

Billions have been invested to date, yet all we see are a few autonomous vehicle pilots running in cities across the country. How will fully driverless cars change mobility forever? What makes the technology so hard? How will connected vehicles and smart infrastructure play a part in bringing this technology to the world? This talk will create a conversation around these questions.

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Livestream / Virtual Wed, 25 Aug 2021 12:53:46 -0400 2021-09-15T14:00:00-04:00 2021-09-15T15:00:00-04:00 Off Campus Location Center for Connected and Automated Transportation Livestream / Virtual Decorative Image to promote Distinguished Lecture Series with Jaime Waydo. It features Jaime's headshot as well as the presentation title
Department of Computational Medicine & Bioinformatics Weekly Seminar Series (September 15, 2021 4:00pm) https://events.umich.edu/event/86598 86598-21635116@events.umich.edu Event Begins: Wednesday, September 15, 2021 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

Chromosomal instability (CIN) results in the accumulation of large-scale losses, gains, and rearrangements of DNA. The broad genomic complexity caused by CIN is a hallmark of cancer, however, there is no systematic framework to measure different types of CIN and their impact on clinical phenotypes. Here, we evaluate the extent, diversity and origin of chromosomal instability across 7,880 tumors representing 33 cancer types from the TCGA collection. We present a compendium of 17 copy number signatures characterizing specific types of CIN, with putative aetiologies supported by multiple independent data sources. The signatures predict drug response and identify new drug targets. Our framework refines the understanding of impaired homologous recombination, one of the most therapeutically targetable types of CIN. Our results illuminate a fundamental structure underlying genomic complexity and provide a resource to guide future CIN
research in human cancers.

Bio:

Florian Markowetz is a Senior Group Leader at the Cancer Research UK Cambridge Institute. He is a Royal Society Wolfson Research Merit Award holder and received a CRUK Future Leader in Cancer Research prize. He holds degrees in Mathematics (Dipl. math.) and Philosophy (M.A.) from the University of Heidelberg and a Dr. rer. nat. (PhD equivalent) in Computational Biology from Free University Berlin, for which he was awarded an Otto-Hahn Medal by the Max Planck Society. His group at the CRUK Cambridge Institute combines computational work on cancer evolution and image analysis of the tumor tissue with experimental work on understanding key cancer mechanisms like the estrogen receptor.

Zoom link: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Thu, 09 Sep 2021 11:24:05 -0400 2021-09-15T16:00:00-04:00 2021-09-15T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual Florian Markowetz (Senior Group Leader at the Cancer Research UK Cambridge Institute)
BME 500 Seminar: Nicholas A. Graham, Ph.D. (September 16, 2021 4:00pm) https://events.umich.edu/event/87034 87034-21638155@events.umich.edu Event Begins: Thursday, September 16, 2021 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Nicholas A. Graham, Ph.D.
Mork Family Department of Chemical Engineering and Materials Science,
University of Southern California

“Systems biology approaches to drug discovery for cancer and aging”

Abstract:

“Omics” technologies have enabled network-level measurements of genes, proteins, and metabolites from cellular models of disease. Systems biology attempts to synthesize these quantitative measurements into data-driven models to explain biological function and identify targeted therapeutic drugs. Here, I will discuss three different engineering systems biology approaches using metabolomics, proteomics, and bioinformatics to identify or discover drugs for cancer and aging. First, using metabolomics, we designed a synergistic drug combination that mimics nutrient deprivation to kill cancer cells. Second, by integrating a proteomic signature of cellular senescence with large-scale drug screening databases, we predicted and then validated that EGFR inhibitors are toxic to a model of cellular aging, specifically senescent human mammary epithelial cells. Finally, we developed a bioinformatic approach to integrate gene expression data with drug screening data from hundreds of cancer cell lines to identify clinically approved drugs whose efficacy depends on metabolic pathway activity. Taken together, these studies demonstrate how metabolomics, proteomics, and bioinformatics can all serve to identify drugs for cancer and aging.

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Lecture / Discussion Wed, 15 Sep 2021 15:08:08 -0400 2021-09-16T16:00:00-04:00 2021-09-16T17:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Event
MEGC Seminar Series (September 16, 2021 5:00pm) https://events.umich.edu/event/86901 86901-21637288@events.umich.edu Event Begins: Thursday, September 16, 2021 5:00pm
Location: GG Brown Laboratory
Organized By: Mechanical Engineering Graduate Council

Abstract (by Mohsen Taheri)

Complex applications in modern technology urgently call for advanced structural materials that are high-strength and lightweight, and yet tolerant to damage from extreme temperature, particle radiation, or environmental exposure. To swiftly fulfill these emerging demanding material requirements, we must develop a multi-scale understanding of the relationship between processing, microstructure, and properties of metallic materials. Toward these goals, I present two examples of my recent findings on (i) how functional behavior of shape memory alloys made by additive manufacturing correlates with the manufacturing history and (ii) how the macroscopic strength of magnesium alloys is governed by local microstructure (grain boundary parameters). I will conclude my talk by discussing how such understandings can be captured in multi-scale modeling tools to predict the deformation of the material and accelerate the development of next-generation structural materials.

Please RSVP here for in-person attendance: https://docs.google.com/forms/d/e/1FAIpQLSePqF9NBGxMdXUXSEag04Vijra_FTXrjaA6P4t4dpXuUd1_eA/viewform?usp=sf_link

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Workshop / Seminar Tue, 14 Sep 2021 00:16:07 -0400 2021-09-16T17:00:00-04:00 2021-09-16T18:00:00-04:00 GG Brown Laboratory Mechanical Engineering Graduate Council Workshop / Seminar MEGC Seminars for the Engineering Community
Opportunity Kick-Off: Preparing a Competitive NIH S10 Instrumentation Proposal (September 17, 2021 12:00pm) https://events.umich.edu/event/85468 85468-21626488@events.umich.edu Event Begins: Friday, September 17, 2021 12:00pm
Location: Off Campus Location
Organized By: OVPR Office of Research Development

Hosted by U-M Research Development and the Biosciences Initiative, this webinar will provide an overview of NIH S10 Instrumentation Grants, including U-M success rates, common reviewer critiques, a timeline for developing a strong proposal, and resources to support your efforts.
Recent S10 awardees will join our panel to discuss their experiences, offer tips for success and answer your questions.

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Workshop / Seminar Thu, 19 Aug 2021 16:59:13 -0400 2021-09-17T12:00:00-04:00 2021-09-17T13:00:00-04:00 Off Campus Location OVPR Office of Research Development Workshop / Seminar Closeup of microscope
NERS Fall 2021 Colloquia (September 17, 2021 4:00pm) https://events.umich.edu/event/84088 84088-21619940@events.umich.edu Event Begins: Friday, September 17, 2021 4:00pm
Location: Cooley Building
Organized By: Nuclear Engineering and Radiological Sciences

FALL 2021 SCHEDULE
Colloquia are at 4pm on Fridays in the White Auditorium (G906 Cooley Building) unless otherwise noted.

SEPTEMBER 10
Ken Powell, Aerospace Engineering, U-M
Increasing Diversity and Inclusion in Academic Departments

SEPTEMBER 17
Todd Allen and Kristine Svinicki, Nuclear Engineering & Radiological Sciences, U-M
Department Welcome

SEPTEMBER 24
Steven Aumeier, Idaho National Laboratory (1:30pm in the GM Room)
Advanced Clean Energy and Production – Accelerating Energy Transitions Through Adaptive Clean Energy and Industrial Capacity

SEPTEMBER 24
Shikha Prasad, Nuclear Engineering, Texas A&M University
Next-Generation Portable Antineutrino Detectors Using Semiconductors

OCTOBER 1
Harsh Desai, Zeno Power Systems
Enabling Space Missions with Radioisotope Power Systems

OCTOBER 22
Assel Aitkaliyeva, University of Florida
Constituent Redistribution in U-Pu-Zr Fuels and its Dependence on Zr Content

OCTOBER 29
Leslie Dewan, Criticality Capital
Nuclear Entrepreneurship: The Good, The Bad, and The Ugly

NOVEMBER 5
Tom Wellock, Nuclear Regulatory Commission
Safe Enough? A History of Nuclear Power and Accident Risk

NOVEMBER 12
Christine King, Idaho National Laboratory, Gateway for Accelerated Innovation in Nuclear
Changing the Establishment from Within: How Small Teams and Initiatives Can Be Incredibly Impactful

NOVEMBER 19
Shannon Bragg-Sitton, Idaho National Laboratory
TBD (topic: integrated energy systems)

DECEMBER 3
Kelsa Palomares, NASA Marshall
Reactor Materials Challenges to Enable Space Nuclear Propulsion

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Workshop / Seminar Mon, 20 Sep 2021 12:35:00 -0400 2021-09-17T16:00:00-04:00 2021-09-17T17:00:00-04:00 Cooley Building Nuclear Engineering and Radiological Sciences Workshop / Seminar Colloquia