Happening @ Michigan https://events.umich.edu/list/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. 20th Annual James V. Neel Lectureship (April 23, 2021 11:00am) https://events.umich.edu/event/83872 83872-21561727@events.umich.edu Event Begins: Friday, April 23, 2021 11:00am
Location: Off Campus Location
Organized By: Department of Human Genetics

DEPARTMENT OF HUMAN GENETICS - 20TH ANNUAL JAMES V. NEEL LECTURESHIP

“Remembrance of Things Past: Reactivation of Fetal Hemoglobin for Therapy.”

Presented by:
Stuart H. Orkin, M.D.
David G. Nathan Distinguished Professor of Pediatrics
Investigator, Howard Hughes Medical Institute
Harvard Medical School

FRIDAY, MAY 7, 2021
12:00PM - 3:00PM EST
Zoom Meeting ID: 983 1136 4189
Zoom Meeting Link: https://umich.zoom.us/j/98311364189

Sponsored by:
The Department of Human Genetics
University of Michigan Medical School
Event Website: https://medicine.umich.edu/dept/human-genetics/events/202105/20th-annual-james-v-neel-lectureship

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Lecture / Discussion Fri, 23 Apr 2021 11:02:42 -0400 2021-04-23T11:00:00-04:00 2021-04-23T12:00:00-04:00 Off Campus Location Department of Human Genetics Lecture / Discussion 2021 JAMES V. NEEL LECTURESHIP FLYER
Gene Editing and the Food We Eat (April 27, 2021 1:00pm) https://events.umich.edu/event/79959 79959-20519521@events.umich.edu Event Begins: Tuesday, April 27, 2021 1:00pm
Location: Off Campus Location
Organized By: Osher Lifelong Learning Institute (50+)

Calling all non-biologists interested in learning how gene editing technology will impact the food in our grocery stores. Make more informed decisions. Learn about GMO food. Understand the concerns about safety and security. Discuss controversial topics including how we feed a growing world population, how crops are developed, GMO labeling, the hope for gene editing, and the role of government regulation.

The course includes online video, articles, and TED talks viewed prior to class, followed by a Zoom conference to discuss controversial topics.

Instructor Bryan Mckersie has 40 years’ experience in leading plant biotechnology research programs.

The study group will meet Tuesdays from April 27 through June 1. Preregistration is required via the OLLI website or phone. A link to access the study group will be e-mailed to you approximately one week prior to the first session.

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Class / Instruction Fri, 11 Dec 2020 19:48:22 -0500 2021-04-27T13:00:00-04:00 2021-04-27T14:30:00-04:00 Off Campus Location Osher Lifelong Learning Institute (50+) Class / Instruction OLLI Study Groups
Seminar: Lindsay M. LaFave, Ph.D., Massachusetts Institute of Technology and Harvard University (May 24, 2021 3:00pm) https://events.umich.edu/event/84070 84070-21619805@events.umich.edu Event Begins: Monday, May 24, 2021 3:00pm
Location: Off Campus Location
Organized By: Life Sciences Institute (LSI)

Abstract:
A key feature of cancer development is the loss of gene regulatory programs that govern normal cellular identity; however, these disrupted regulatory landscapes, or epigenomic states, are not well understood. To study epigenomic state changes in the natural evolution of lung adenocarcinoma (LUAD), I utilized the well-established KrasG12D/+p53-/- (KP) murine model of LUAD progression. Using an optimized single-cell ATAC-sequencing approach with combinatorial indexing, I profiled the chromatin accessibility states of individual KP tumors, metastases, and normal lungs. Strikingly, we identified expansive epigenomic heterogeneity across cancer progression; yet, these cell states followed reproducible trajectories across individual tumors—suggesting conserved paths toward metastasis. We utilized computational tools to identify 11 discernable states across LUAD cancer progression characterized by transcription factor (TF) regulators and downstream regulated genes. These analyses led to the identification of a late-stage program associated with progressive RUNX2 activation and adverse survival in human patients. Together, these results demonstrated the utility of single-cell epigenomics to identify TF-driven regulatory programs as key biomarkers of cancer progression. My ongoing work leverages evolving epigenomic technologies in murine and organoid systems to understand the overarching mechanisms dictating altered chromatin state in cancer.

Speaker:
Lindsay M. LaFave is a cancer biologist with a long-standing interest in studying chromatin biology. Lindsay completed her B.S. in biochemistry at the University of Michigan in 2009. She received her Ph.D. in Cancer Biology at Gerstner Sloan Kettering Graduate School in New York City in 2015. Her graduate research in Ross Levine’s lab at Memorial Sloan Kettering Cancer Center focused on studying the role of mutated chromatin modifying proteins in hematopoietic malignancies. For her postdoctoral training, she continued to study epigenetic mechanisms of cancer progression, shifting her primary focus to solid tumors. Lindsay is a current Damon Runyon postdoctoral fellow in the labs of Tyler Jacks at MIT and Jason Buenrostro at Harvard University. Her work leverages murine modeling and single-cell epigenomic technologies to understand cell state changes that occur during cancer progression in lung adenocarcinoma. During her postdoctoral training, Lindsay identified a diverse repertoire of gene regulatory changes important in cancer progression that were associated with altered cellular identity and the emergence of pre-metastatic gene programs. Her independent research group will utilize evolving epigenomic technologies and cancer models to dissect chromatin-mediated mechanisms driving lung cancer.

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Lecture / Discussion Tue, 18 May 2021 10:45:17 -0400 2021-05-24T15:00:00-04:00 2021-05-24T16:00:00-04:00 Off Campus Location Life Sciences Institute (LSI) Lecture / Discussion
Precision Health Webinar (May 25, 2021 1:00pm) https://events.umich.edu/event/83924 83924-21617135@events.umich.edu Event Begins: Tuesday, May 25, 2021 1:00pm
Location: Off Campus Location
Organized By: Precision Health

Precision Health at the University of Michigan (U-M) invites you to engage with two outstanding Scholars who have been funded by Precision Health to develop their research.
Arun Subramaniyan, BE, MS (graduate student, College of Engineering): “Hardware-accelerated systems for next-generation sequencing analysis”

Alyse Krausz, BS, MS (graduate student research assistant, Biomedical Engineering): “A Point-of-Care Microfluidic System for Traumatic Brain Injury Diagnosis and Prognosis”

You'll hear more about their work and how they used Precision Health resources in these innovative projects.

**Please register to attend. We will send a link to the virtual presentation a few days in advance. We hope you'll join us!**

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Livestream / Virtual Tue, 04 May 2021 13:45:53 -0400 2021-05-25T13:00:00-04:00 2021-05-25T14:00:00-04:00 Off Campus Location Precision Health Livestream / Virtual May 2021 PH Webinar
Human Genetics Annual Retreat - Keynote Seminar (September 10, 2021 2:00pm) https://events.umich.edu/event/86250 86250-21632243@events.umich.edu Event Begins: Friday, September 10, 2021 2:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Department of Human Genetics

FRIDAY, SEPTEMBER 10
2:00 PM – 3:00 PM EST
BSRB KAHN AUDITORIUM
109 ZINA PITCHER PL, ANN ARBOR

HOSTED BY:
Jacob Mueller, Ph.D.
Associate Professor of Human Genetics
Associate Professor of Obstetrics and Gynecology
Associate Professor of Urology
University of Michigan

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Lecture / Discussion Thu, 02 Sep 2021 16:36:15 -0400 2021-09-10T14:00:00-04:00 2021-09-10T15:00:00-04:00 Taubman Biomedical Science Research Building Department of Human Genetics Lecture / Discussion DHG RETREAT 2021_Keynote Speaker Flyer
CRISPR and the Food We Eat (October 7, 2021 1:00pm) https://events.umich.edu/event/85552 85552-21626842@events.umich.edu Event Begins: Thursday, October 7, 2021 1:00pm
Location: Off Campus Location
Organized By: Osher Lifelong Learning Institute (50+)

CRISPR technology is changing the medical treatments for genetic disorders, but gene editing will also change the food we buy in grocery stores.

Topics include an introduction to DNA and gene editing technology, feeding a growing world population, developing new crop varieties, creating a GMO, food labeling, and government regulation. Will scientists using gene editing make the same mistakes as they did with GMO? The course requires participants to view online video, articles and TED talks prior to class, followed by a Zoom conference to discuss controversial topics.

Instructor Brian McKersie has 40 years’ experience in leading plant biotechnology research.

This study group will meet on Thursdays for five weeks beginning on October 7. Preregistration is required via the OLLI website or phone. A link to access the study group will be e-mailed prior to the first session.

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Class / Instruction Tue, 24 Aug 2021 11:52:09 -0400 2021-10-07T13:00:00-04:00 2021-10-07T14:30:00-04:00 Off Campus Location Osher Lifelong Learning Institute (50+) Class / Instruction OLLI Study Groups
Hacking Darwin: Genetic Engineering and the Future of Humanity (January 17, 2022 10:00am) https://events.umich.edu/event/90061 90061-21667692@events.umich.edu Event Begins: Monday, January 17, 2022 10:00am
Location: Off Campus Location
Organized By: Osher Lifelong Learning Institute (50+)

Recent advances in genetics, reproductive technologies, data analysis and artificial intelligence allow us to treat and cure hereditary disease and solve many biological problems.
This class is based on Jamie Metzl's book (same name) that describes an exhilarating but frightening future involving screening, altering and writing genetic code, which is driven by competition and parent's instinct to give their children every advantage.
The class will address the science, his predictions and alternative visions. Bryan McKersie leads this study group that meets Mondays beginning January 17 through February 7.
Pre-registration is required via the OLLI website or phone. A link to access the study group will be e-mailed to you approximately one week prior to the first session.

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Class / Instruction Wed, 15 Dec 2021 13:32:26 -0500 2022-01-17T10:00:00-05:00 2022-01-17T12:00:00-05:00 Off Campus Location Osher Lifelong Learning Institute (50+) Class / Instruction Study Group
LSI Seminar Series: William C. Mobley, M.D., Ph.D., University of California, San Diego (March 17, 2022 12:00pm) https://events.umich.edu/event/92761 92761-21695328@events.umich.edu Event Begins: Thursday, March 17, 2022 12:00pm
Location: Palmer Commons
Organized By: Life Sciences Institute (LSI)

Synapse dysfunction and loss are hallmarks of Alzheimer’s disease (AD), responsible for its clinical manifestations. Defining the molecular basis for deficits in synapse structure and function are essential for elucidating AD pathogenesis and promise to enhance discovery of effective treatments. Elderly adults with Down syndrome (DS) demonstrate many of the clinical and pathological manifestations of AD; the condition is referred to as AD-DS. While age is an important risk factor for both AD and AD-DS, how age intersects with underlying changes in brain function are unclear. Studies in DS provide an opportunity to decipher the biology that underlies the impact of age on the genetic factor known to be necessary for AD-DS, an increase in APP copy number. Studies of synapse dysfunction and loss are not well investigated in those with AD-DS. We will explore the age by gene interaction through cell biological and in vivo studies in a mouse model and in the AD-DS brain.


**About the Speaker**
William Mobley is a Distinguished Professor of Neurosciences and Associate Dean for Neurosciences Initiatives at the University of California, San Diego. He came to UCSD in June of 2009 from Stanford University, where he served as the John E. Cahill Family Professor in the Department of Neurology and Neurological Sciences and was the founding director of the Neuroscience Institute. He earned his Ph.D. in neuro- & behavioral science from Stanford University in Palo Alto, California in 1974 and an M.D. from the same institution in 1976. Dr. Mobley completed an internship in pathology in 1977 and a pediatric residency in 1979, both at Stanford University, followed by a residency and fellowship in Neurology and Pediatric Neurology at The Johns Hopkins University. While there, he was selected to serve as chief resident in pediatric neurology from 1981 to 1982. He is certified by both the American Board of Pediatrics and the American Board of Psychiatry and Neurology with Special Competence in Child Neurology. He is a past president of the Association of University Professors of Neurology, the Professors of Child Neurology, and the International Society for Developmental Neuroscience. He is also a Fellow of the Royal College of Physicians an elected member of the National Academy of Medicine. In 2006, Dr. Mobley was named a Fellow of the American Association for the Advancement of Science, in 2011 received the International Sisley-Jérôme Lejeune Prize for research in Down Syndrome, and in 2014 was named to the Johns Hopkins Society of Scholars. Dr. Mobley currently serves as president of the T21 Research Society. In 2019 he was appointed interim Director of the Sanford Institute for Empathy and Compassion. His research focuses on the biology of Alzheimer's disease, especially as manifest in those with Down syndrome. It encompasses studies that extend from basic cellular mechanisms to the discovery of treatments and to the compassionate care of these individuals.

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Lecture / Discussion Thu, 24 Feb 2022 15:46:30 -0500 2022-03-17T12:00:00-04:00 2022-03-17T13:00:00-04:00 Palmer Commons Life Sciences Institute (LSI) Lecture / Discussion Life Sciences Institute Seminar Series
2022 Investigators Awards Launch Event (April 7, 2022 10:00am) https://events.umich.edu/event/92973 92973-21698652@events.umich.edu Event Begins: Thursday, April 7, 2022 10:00am
Location: Off Campus Location
Organized By: Precision Health

Join us for a lively, fast-paced series of presentations (3 minutes each!) by our most recently funded project PIs. Hear what exciting challenges they're taking on and see how multidisciplinary teams are working together to improve health.

After these presentations, we will open breakout rooms to invite your ideas on the following topics:
Tackling Health Disparities through Precision Health
New Advances in Health Image Analysis
Using Genetic Information to Individualize Patient Care
Reinforcement Learning & Causal Inference in Healthcare
Learning from Multi-institution EHR data Opportunities to Enhance Data Sharing and Collaboration
What's missing from Precision Health resources?

The launching projects include:
Anouck Girard (COE), Josephine Kasa-Vubu (Med), Michael DiPietro (Med) -- "Using Artificial Intelligence To Broaden and Diversify Outdated Standards for the Determination of Skeletal Maturation in Growing Children"

Todd Hollon (COE), Honglak Lee (COE), Sandra Camelo-Piragua (Med) -- "Rapid Intraoperative Molecular Diagnosis of Diffuse Gliomas Using Stimulated Raman Histology and Deep Neural Networks"

Hui Jiang (SPH) -- "Statistical and Computational Methods for Asymmetric Integration of Datasets from Different Cancers for the Identification of Cancer-related Genes and Biomarkers in Case-control Analyses"

Michael Mathis (Med) -- "Predicting Cardiac Surgery-Associated Acute Kidney Injury using Federated Learning"

Amy Pasternak (Pharm), Vaibhav Sahai (Med) -- "Assessing the Impact of Germline Pharmacogenetics (PGx) on Medication Outcomes and Clinician Prescribing Decisions in Patients with Cancer"

Scott Peltier (BME), Zhongming Liu (BME) -- "Deep Learning for Prediction of Mild Cognitive Impairment and Dementia of the Alzheimer’s Type"

Xu Shi (SPH) -- "Automated Harmonization of Multi-institutional Electronic Health Records Data"


Questions? Contact Tina Creguer, tcreguer@umich.edu.

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Presentation Thu, 03 Mar 2022 16:52:49 -0500 2022-04-07T10:00:00-04:00 2022-04-07T11:30:00-04:00 Off Campus Location Precision Health Presentation Precision Health Investigators Awards