Happening @ Michigan https://events.umich.edu/list/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. Investigating Protein Degradation at the Interface of Chemistry and Biology (January 28, 2020 11:45am) https://events.umich.edu/event/70908 70908-17735213@events.umich.edu Event Begins: Tuesday, January 28, 2020 11:45am
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Faculty Candidate
Host: U. Jakob

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Workshop / Seminar Fri, 24 Jan 2020 13:28:03 -0500 2020-01-28T11:45:00-05:00 2020-01-28T12:45:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials on blue background
DCMB Seminar Series (January 29, 2020 4:00pm) https://events.umich.edu/event/71998 71998-17911963@events.umich.edu Event Begins: Wednesday, January 29, 2020 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Talk Title: Experimental and computational strategies to aid compound identification and quantitation in metabolomics

Abstract: Over the past two decades, metabolomics as a technique has moved from the primary domain of analytical chemists to more widespread acceptance by biologists, clinicians and bioinformaticians alike. Metabolomics offers systems-level insights into the critical roles small molecules play in routine cellular processes and myriad disease states. However, certain unique analytical challenges remain prominent in metabolomics as compared to the other ‘omics sciences. These include the difficulty of identifying unknown features in untargeted metabolomics data, and challenges maintaining reliable quantitation within lengthy studies that may span multiple laboratories. Unlike genomics and transcriptomics data in which nearly every quantifiable feature is confidently identified as a matter of course, in typical untargeted metabolomics studies over 80% of features are frequently not mapped to a specific chemical compound. Further, although many metabolomics studies have begun to stretch over a timeframe of years, data quantitation and normalization strategies have not always kept up with the requirements for such large studies. Fortunately, both experimental and computational strategies are emerging to tackle these long-standing challenges. We will report on several techniques in development in our laboratory, ranging from chromatographic fractionation and high-sensitivity data acquisition, to computational strategies to aid in tandem mass spectrometric spectral interpretation. These developments serve to facilitate analysis for both experts and novice users, which should ultimately help improve the biological insight and impact gained from metabolomics data.

BlueJeans livestreaming link: https://primetime.bluejeans.com/a2m/live-event/rbuvycdc

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Lecture / Discussion Fri, 24 Jan 2020 11:07:13 -0500 2020-01-29T16:00:00-05:00 2020-01-29T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
Statistics Department Seminar Series: Dylan Small, Professor, Department of Statistics, The Wharton School, University of Pennsylvania (January 31, 2020 10:00am) https://events.umich.edu/event/69915 69915-17483046@events.umich.edu Event Begins: Friday, January 31, 2020 10:00am
Location: West Hall
Organized By: Department of Statistics

Gun violence is a problem in America. There are many unresolved questions about what policies would reduce gun violence. I will discuss two attempts at causal inference about gun violence prevention policies that I have worked on, and highlight some ideas about causal inference I have sought to use in this work.

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Workshop / Seminar Fri, 10 Jan 2020 12:13:43 -0500 2020-01-31T10:00:00-05:00 2020-01-31T11:00:00-05:00 West Hall Department of Statistics Workshop / Seminar Dylan Small
Declare ECE! (January 31, 2020 11:30am) https://events.umich.edu/event/71415 71415-17825624@events.umich.edu Event Begins: Friday, January 31, 2020 11:30am
Location: Electrical Engineering and Computer Science Building
Organized By: Electrical and Computer Engineering

Seeking to declare your CoE major? Attend Declare ECE! and learn more about the exciting and innovative field of electrical engineering and computer engineering and how you can pursue an ECE degree!

Electrical and computer engineering is at the heart of modern technology and innovation, including computers, cars, robotics, energy and more. ECE will provide the skills you need to CHANGE THE WORLD and GET A JOB!!!

Pizza will be provided!

Visit our website to RSVP for the event.

Scheduled Activities at Event:

– Opening presentation from Professor P.C. Ku, Associate Chair of ECE Undergraduate Affairs

– Presentation on available events and activities for ECE students

– Panel of current ECE students

– Learn about Fall 2020’s EECS 200 that offers hands-on design, build, and test opportunities

– Learn about Major Design Experience (MDE) options

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Workshop / Seminar Tue, 14 Jan 2020 08:43:41 -0500 2020-01-31T11:30:00-05:00 2020-01-31T12:30:00-05:00 Electrical Engineering and Computer Science Building Electrical and Computer Engineering Workshop / Seminar Declare ECE! Photo
Economics at Work (January 31, 2020 1:00pm) https://events.umich.edu/event/70946 70946-17758141@events.umich.edu Event Begins: Friday, January 31, 2020 1:00pm
Location: Lorch Hall
Organized By: Department of Economics

Economics@Work is intended for any student who is interested in learning about a variety of career opportunities for economics majors. Early students of economics may use this class to explore whether an economics major best suits their interests and goals. Advanced students in economics will benefit from the information and networking opportunities.

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Workshop / Seminar Thu, 09 Jan 2020 10:58:56 -0500 2020-01-31T13:00:00-05:00 2020-01-31T14:10:00-05:00 Lorch Hall Department of Economics Workshop / Seminar Economics
BME Student Speaker: Xiaotian Tan (February 3, 2020 12:00pm) https://events.umich.edu/event/72234 72234-17963872@events.umich.edu Event Begins: Monday, February 3, 2020 12:00pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: Biomedical Engineering

Biosensors are devices or systems that can be used to detect, quantify, and analyze targets with biological activities and functions. As one of the largest subsets of biosensors, biomolecular sensors are specifically developed and programmed to detect, quantify and analyze biomolecules in liquid samples. Wide-ranging applications have made immunoassays increasingly popular for biomolecular detection and quantification. Among these, enzyme-linked immunosorbent assays (ELISA) are of particular interest due to high specificity and reproducibility. To some extent, ELISA has been regarded as a “gold standard” for quantifying analytes (especially protein analytes) in both clinical diagnostics and fundamental biological research. However, traditional (96-well plate-based) ELISA still suffers from several notable drawbacks, such as long assay time (4–6 hours), lengthy procedures, and large sample/reagent consumption (∼100 μL). These inherent disadvantages still significantly limit traditional ELISA's applicability to areas such as rapid clinical diagnosis of acute diseases (e.g., viral pneumonia, acute organ rejection), and biological research that requires accurate measurements with precious or low abundance samples (e.g., tail vein serum from a mouse). Thus, a bimolecular sensing technology that has high sensitivity, short assay time, and small sample/reagent consumption is still strongly desired. In this dissertation, we introduce the development of a multifunctional and automated optofluidic biosensing platform that can resolve the aforementioned problems. In contrast to conventional plate-based ELISA, our optofluidic ELISA platform utilizes mass-producible polystyrene microfluidic channels with a high surface-to-volume ratio as the immunoassay reactors, which greatly shortens the total assay time. We also developed a low-noise signal amplification protocol and an optical signal quantification system that was optimized for the optofluidic ELISA platform. Our optofluidic ELISA platform provides several attractive features such as small sample/reagent consumption (<8 μL), short total assay time (30-45 min), high sensitivity (~1 pg/mL for most markers), and a broad dynamic range (3-4 orders of magnitude). Using these features, we successfully quantified mouse FSH (follicle stimulating hormone) concentration with a single drop of tail vein serum. We also successfully monitored bladder cancer progression in orthotopic xenografted mice with only <50 μL of mouse urine. More excitingly, we achieved highly-sensitive exosome quantification and multiplexed immuno-profiling with <40 ng/mL of total input protein (per assay). These remarkable milestones could not be achieved with conventional plate-based ELISA but were enabled by our unique optofluidic ELISA.

As an emerging member of the bimolecular sensor family, our optofluidic ELISA platform provides a high-performance and cost-effective tool for a plethora of applications, including endocrinal, cancer animal model, cellular biology, and even forensic science research. In the future, this technology platform can also be renovated for clinical applications such as personalized cancer diagnosis/prognosis and rapid point-of-care diagnostics for infectious diseases.

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Lecture / Discussion Thu, 30 Jan 2020 09:19:52 -0500 2020-02-03T12:00:00-05:00 2020-02-03T13:00:00-05:00 Lurie Biomedical Engineering (formerly ATL) Biomedical Engineering Lecture / Discussion Xiaotian Tan
MCDB Remembering the past and rewiring the future: A protein-based inheritance paradigm (February 4, 2020 11:45am) https://events.umich.edu/event/70910 70910-17735215@events.umich.edu Event Begins: Tuesday, February 4, 2020 11:45am
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Faculty Candidate
Host: R. Stockbridge

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Workshop / Seminar Fri, 24 Jan 2020 13:31:02 -0500 2020-02-04T11:45:00-05:00 2020-02-04T12:45:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials and yellow microscope on blue background
Temporal Regulation of the Blood-Brain Barrier (February 6, 2020 11:45am) https://events.umich.edu/event/70911 70911-17735216@events.umich.edu Event Begins: Thursday, February 6, 2020 11:45am
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Faculty Candidate
Host: G. Csankovszki & Wilinski

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Workshop / Seminar Fri, 24 Jan 2020 13:28:56 -0500 2020-02-06T11:45:00-05:00 2020-02-06T12:45:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials and yellow microscope on blue background
Statistics Department Seminar Series: David Blei, Professor, Department of Statistics and Computer Science, Columbia University (February 7, 2020 10:00am) https://events.umich.edu/event/69917 69917-17483049@events.umich.edu Event Begins: Friday, February 7, 2020 10:00am
Location: West Hall
Organized By: Department of Statistics

Abstract: Causal inference from observational data is a vital problem, but it comes with strong assumptions. Most methods require that we observe all confounders, variables that affect both the causal variables and the outcome variables. But whether we have observed all confounders is a famously untestable assumption. We describe the deconfounder, a way to do causal inference with weaker assumptions than the classical methods require.

How does the deconfounder work? While traditional causal methods measure the effect of a single cause on an outcome, many modern scientific studies involve multiple causes, different variables whose effects are simultaneously of interest. The deconfounder uses the correlation among multiple causes as evidence for unobserved confounders, combining unsupervised machine learning and predictive model checking to perform causal inference. We demonstrate the deconfounder on real-world data and simulation studies, and describe the theoretical requirements for the deconfounder to provide unbiased causal estimates.

This is joint work with Yixin Wang. [*] https://www.tandfonline.com/doi/full/10.1080/01621459.2019.1686987

Biography: David Blei is a Professor of Statistics and Computer Science at Columbia University, and a member of the Columbia Data Science Institute. He studies probabilistic machine learning, including its theory, algorithms, and application. David has received several awards for his research, including a Sloan Fellowship (2010), Office of Naval Research Young Investigator Award (2011), Presidential Early Career Award for Scientists and Engineers (2011), Blavatnik Faculty Award (2013), ACM-Infosys Foundation Award (2013), a Guggenheim fellowship (2017), and a Simons Investigator Award (2019). He is the co-editor-in-chief of the Journal of Machine Learning Research. He is a fellow of the ACM and the IMS.

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Workshop / Seminar Thu, 30 Jan 2020 10:19:09 -0500 2020-02-07T10:00:00-05:00 2020-02-07T11:00:00-05:00 West Hall Department of Statistics Workshop / Seminar David Blei
MFG Research-Smart Manufacturing Seminar - Human-Robot Collaboration: Current Status and Future Trends (February 7, 2020 11:00am) https://events.umich.edu/event/72189 72189-17955062@events.umich.edu Event Begins: Friday, February 7, 2020 11:00am
Location: Chrysler Center
Organized By: Integrative Systems + Design

Abstract
Human-robot collaboration has attracted increasing attention, both in academia and in industry. For example, in human-robot collaborative assembly, robots are often required to dynamically change their pre-planned tasks to collaborate with human operators in a shared workspace. However, the robots used today are controlled by pre-generated rigid codes that cannot support effective human-robot collaboration. In response to this need, multi-modal yet symbiotic communication and control methods have been developed. These methods include voice processing, gesture recognition, haptic interaction, and brainwave perception. Deep learning is used for classification, recognition and context awareness identification. Within this context, this seminar provides an overview of the current status of human-robot collaboration including its classification, definition and characteristics. At the end of the seminar, remaining challenges and future research directions will be highlighted.

Speaker Bio
Lihui Wang is a Chair Professor of Sustainable Manufacturing at KTH Royal Institute of Technology, Sweden. His research interests are focused on cyber-physical systems, human-robot collaboration, real-time monitoring and control, predictive maintenance, adaptive and sustainable manufacturing systems. Professor Wang is actively engaged in various professional activities. He is the Editor-in-Chief of Robotics and Computer-Integrated Manufacturing, Editor-in-Chief of International Journal of Manufacturing Research, and Editor-in-Chief of Journal of Manufacturing Systems. He has published 9 books and authored in excess of 500 scientific publications. Professor Wang is a Fellow of Canadian Academy of Engineering, CIRP, SME and ASME, the President-Elect of North American Manufacturing Research Institution of SME, and the Chairman of Swedish Production Academy.

Co-organized by:
Judy Jin (Program Director, ISD Manufacturing; Professor IOE)
Chinedum Okwudire (Associate Chair, ISD; Associate Professor, ME)

Contact: Kathy Bishar (kbishar@umich.edu)

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Workshop / Seminar Wed, 29 Jan 2020 08:17:52 -0500 2020-02-07T11:00:00-05:00 2020-02-07T12:00:00-05:00 Chrysler Center Integrative Systems + Design Workshop / Seminar Lihui Wang
Economics at Work (February 7, 2020 1:00pm) https://events.umich.edu/event/70947 70947-17760216@events.umich.edu Event Begins: Friday, February 7, 2020 1:00pm
Location: Lorch Hall
Organized By: Department of Economics

Economics@Work is intended for any student who is interested in learning about a variety of career opportunities for economics majors. Early students of economics may use this class to explore whether an economics major best suits their interests and goals. Advanced students in economics will benefit from the information and networking opportunities.

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Workshop / Seminar Thu, 09 Jan 2020 10:59:24 -0500 2020-02-07T13:00:00-05:00 2020-02-07T14:10:00-05:00 Lorch Hall Department of Economics Workshop / Seminar Economics
Department of Computational Medicine & Bioinformatics (DCMB) Weekly Seminar (February 12, 2020 4:00pm) https://events.umich.edu/event/72535 72535-18015945@events.umich.edu Event Begins: Wednesday, February 12, 2020 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract:
Normal mechanical function of the heart requires that ATP be continuously synthesized at a hydrolysis potential of roughly -60 kJ mol-1. Yet in both the aging and diseased heart the relationships between cardiac work rate and concentrations of ATP, ADP, and inorganic phosphate are altered. Important outstanding questions are: To what extent do changes in metabolite concentrations that occur in aging and heart disease affect metabolic/molecular processes in the myocardium? How are systolic and diastolic functions affected by changes in metabolite concentrations? Does metabolic energy supply represent a limiting factor in determining physiological maximal cardiac power output and exercise capacity? Does the derangement of cardiac energetics that occurs with heart failure cause exercise intolerance?

To answer these questions, we have developed a multi-physics multi-scale model of cardiac energy metabolism and cardiac mechanics that simulates the dependence of myocardial ATP demand on muscle dynamics and the dependence of muscle dynamics on cardiac energetics. Model simulations predict that the maximal rate at which ATP can be synthesized at free energies necessary to drive physiological mechanical function determine maximal heart rate, cardiac output, and cardiac power output in exercise. Furthermore, we find that reductions in cytoplasmic adenine nucleotide, creatine, and phosphate pools that occur with aging impair the myocardial capacity to synthesize ATP at physiological free energy levels, and that the resulting changes to myocardial energetic status play a causal role in contributing to reductions in maximal cardiac power output with aging. Finally, model predictions reveal that reductions in cytoplasmic metabolite pools contribute to energetic dysfunction in heart failure, which in turn contributes to causing systolic dysfunction in heart failure.

BlueJeans Livestream Link: https://primetime.bluejeans.com/a2m/live-event/rbuvycdc

3:45 p.m. - Light Refreshments served in Forum Hall Atrium
4:00 p.m. - Lecture in Forum Hall

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Lecture / Discussion Wed, 05 Feb 2020 08:41:29 -0500 2020-02-12T16:00:00-05:00 2020-02-12T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion
Revealing Principles of Subcellular RNA Localization (February 13, 2020 2:00pm) https://events.umich.edu/event/70912 70912-17735217@events.umich.edu Event Begins: Thursday, February 13, 2020 2:00pm
Location: Palmer Commons
Organized By: Department of Molecular, Cellular, and Developmental Biology

Faculty Candidate
Host: A. Wierzbicki and the Life Sciences Institute

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Workshop / Seminar Tue, 28 Jan 2020 11:22:53 -0500 2020-02-13T14:00:00-05:00 2020-02-13T15:00:00-05:00 Palmer Commons Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials and yellow microscope on blue background
Distinguished Alumni Speaker Series: Earl Lawrence, Statistical Sciences, Los Alamos National Laboratory (February 14, 2020 10:00am) https://events.umich.edu/event/69918 69918-17483050@events.umich.edu Event Begins: Friday, February 14, 2020 10:00am
Location: West Hall
Organized By: Department of Statistics

Abstract:
Inference with computationally expensive physics models is a big part of statistics at Los Alamos National Laboratory. The first part of that talk will cover some well-known background on the statistical approach computer experiments. This will take place in the context of ongoing work for ChemCam, an instrument on the Mars rover Curiosity whose goal is to determine whether Mars ever had conditions that could have supported microbial life. ChemCam uses laser-induced breakdown spectroscopy to analyze the chemical composition of Martian soil and rocks. Our goal is to use the resulting spectra and a LANL-developed predictive model to estimate the elemental abundances from surface samples. The second part of the talk will cover new work to address computer experiments from exascale supercomputers. The next generation of supercomputers are expected to have I/O limitations relative to their computing ability: they will simulate more than they can save. This requires changes to our usual post-hoc analysis scheme. To address this, we are developing approaches to in situ statistical inference, statistical modeling that gets done inside simulations as they are running. Our early work considers modeling extremes for climate and space weather.

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Workshop / Seminar Wed, 05 Feb 2020 14:37:54 -0500 2020-02-14T10:00:00-05:00 2020-02-14T11:00:00-05:00 West Hall Department of Statistics Workshop / Seminar Earl Lawrence
MCIRCC Re-Imagining Critical Care Seminar Series (February 17, 2020 3:00pm) https://events.umich.edu/event/71948 71948-17903306@events.umich.edu Event Begins: Monday, February 17, 2020 3:00pm
Location: North Campus Research Complex Building 10
Organized By: Michigan Center for Integrative Research in Critical Care (MCIRCC)

“Innovation Fundamentals & Opportunities in Critical Care Biomarker Discovery”

Frederick Korley MD, PhD is an Associate Professor of Emergency Medicine.

Dr. Korley's research activities involve translation of novel diagnostics to inform clinically rational, timely, and cost-effective diagnosis of cardiac and brain injury in the emergency department. The goal of his traumatic brain injury work is to improve the acute care diagnosis, risk-stratification and treatment of TBI by identifying distinct molecular subtypes of TBI that will allow for targeted treatment and improved outcomes.

DETAILS & REGISTRATION:
http://bit.ly/FrederickKorley

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Workshop / Seminar Thu, 23 Jan 2020 12:02:33 -0500 2020-02-17T15:00:00-05:00 2020-02-17T16:00:00-05:00 North Campus Research Complex Building 10 Michigan Center for Integrative Research in Critical Care (MCIRCC) Workshop / Seminar MCIRCC Re-Imagining Critical Care Seminar Series with Dr. Frederick K. Korley Flyer
Genetics Training Program / CMB Short Course (630) (February 18, 2020 3:00pm) https://events.umich.edu/event/72320 72320-17974673@events.umich.edu Event Begins: Tuesday, February 18, 2020 3:00pm
Location: Medical Science Unit II
Organized By: Department of Human Genetics

Welcome to the Exciting World of Tandem and Interspersed DNA Repeat Elements
Presented By Jayakrishnan Nandakumar, Ph.D.
Associate Professor
Department of Molecular, Cellular, and Developmental Biology University of Michigan Medical School
Tuesday, February 18, 2020
3:00 p.m.
West Lecture Hall, Med Sci II

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Lecture / Discussion Fri, 31 Jan 2020 13:25:19 -0500 2020-02-18T15:00:00-05:00 2020-02-18T16:00:00-05:00 Medical Science Unit II Department of Human Genetics Lecture / Discussion Nandakumar GTP / CMB Short Course Flyer
DS/CSS Seminar Series: Julia Mendelsohn (February 20, 2020 12:00pm) https://events.umich.edu/event/72978 72978-18120897@events.umich.edu Event Begins: Thursday, February 20, 2020 12:00pm
Location: North Quad
Organized By: School of Information

PhD candidate Julia Mendelsohn will discuss the creation of a computational linguistic framework for analyzing dehumanizing language and the application of that framework to discussions of LGBTQ people in the New York Times from 1986 to 2015.

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Workshop / Seminar Mon, 17 Feb 2020 14:59:28 -0500 2020-02-20T12:00:00-05:00 2020-02-20T13:00:00-05:00 North Quad School of Information Workshop / Seminar Julia Mendelsohn
Microfluidics Seminar: Dr. Xufeng Xue (February 20, 2020 12:00pm) https://events.umich.edu/event/73026 73026-18129602@events.umich.edu Event Begins: Thursday, February 20, 2020 12:00pm
Location: Pierpont Commons
Organized By: Biomedical Engineering

Neurulation is a key embryonic developmental process that gives rise to neural tube (NT), the precursor structure that eventually develops into the central nervous system (CNS). Understanding the molecular mechanisms and morphogenetic events underlying human neurulation is important for the prevention and treatment of neural tube defects (NTDs) and neurodevelopmental disorders. However, animal models are limited in revealing many fundamental aspects of neurulation that are unique to human CNS development. Furthermore, the technical difficulty and ethical constraint in accessing neurulation-stage human embryos have significantly limited experimental investigations of early human CNS development.
I leveraged the developmental potential and self-organizing property of human pluripotent stem cells (hPSCs) in conjunction with 2D and 3D bioengineering tools to achieve the development of spatially patterned multicellular tissues that mimic certain aspects of human neurulation, including neuroectoderm patterning and dorsal-ventral (DV) patterning of NT.
In the first section, I report a micropatterned hPSC-based neuroectoderm model, wherein pre-patterned geometrical confinement induces emergent patterning of neuroepithelial (NE) and neural plate border (NPB) cells, mimicking neuroectoderm patterning during early neurulation. My data support the hypothesis that in this hPS cell-based neuroectoderm patterning model, two tissue-scale morphogenetic signals, cell shape and cytoskeletal contractile force, instruct NE / NPB patterning via BMP-SMAD signaling. This work provides evidence of tissue mechanics-guided neuroectoderm patterning and establishes a tractable model to study signaling crosstalk involving both biophysical and biochemical determinants in neuroectoderm patterning.
In the second section, I report a human NT development model, in which NT-like tissues, termed NE cysts, are generated in a bioengineered neurogenic environment through self-organization of hPSCs. DV patterning of NE cysts is achieved using retinoic acid and/or Sonic Hedgehog, featuring sequential emergence of the ventral floor plate, p3 and pMN domains in discrete, adjacent regions and dorsal territory that is progressively restricted to the opposite dorsal pole.

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Lecture / Discussion Tue, 18 Feb 2020 08:58:46 -0500 2020-02-20T12:00:00-05:00 2020-02-20T13:00:00-05:00 Pierpont Commons Biomedical Engineering Lecture / Discussion BME Logo
BME 500: Ruixuan Gao (February 20, 2020 4:00pm) https://events.umich.edu/event/70421 70421-17594473@events.umich.edu Event Begins: Thursday, February 20, 2020 4:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Investigation of the molecular basis of a complex biological system, such as the brain, can lead to fundamental understanding of its composition and function, and to a new strategy to repair it. Such investigation, however, requires a tool that can capture biological structures and their molecular constituents across multiple orders of magnitude—from nanometers to centimeters—in length. Electron microscopy offers nanoscopic resolution but lacks molecular information to differentiate endogenous biomolecules as well as imaging speed to cover millimeter-scale specimens. Light microscopy provides molecular contrast but is limited by optical diffraction and the tradeoff between imaging speed and photobleaching.

In this talk, I will first introduce an optical imaging pipeline named expansion lattice light-sheet microscopy (ExLLSM) and its application to multiplexed, volumetric imaging of molecular constituents in cells and intact tissues. Using ExLLSM, our study has revealed molecular-specific structures of organelles, synapses, myelin sheaths, and neurites in rodent and insect brains at ∼60 by 60 by 90 nm effective resolution across dimensions that span millimeters. Next, I will present two recently developed methods that further extend the resolution and throughput of ExLLSM: (1) a non-radical hydrogel chemistry that forms a homogenous polymer network and physically separates biomolecules or fluorescent labels up to 40-fold linearly, and (2) a multi-modal optical microscopy that enables rapid, high-resolution imaging of both expanded and live tissues. Lastly, I will discuss the significance of these imaging methods in the context of microanatomy and functional omics.

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Lecture / Discussion Thu, 13 Feb 2020 10:34:18 -0500 2020-02-20T16:00:00-05:00 2020-02-20T17:00:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Lecture / Discussion BME Logo
Statistics Department Seminar Series: Bhaswar Bhattacharya, Assistant Professor, Department of Statistics, The Wharton School, University of Pennsylvania (February 21, 2020 10:00am) https://events.umich.edu/event/69919 69919-17483051@events.umich.edu Event Begins: Friday, February 21, 2020 10:00am
Location: West Hall
Organized By: Department of Statistics

Abstract: Two of the fundamental problems in non-parametric statistical inference are goodness-of-fit and two-sample testing. These two problems have been extensively studied and several multivariate tests have been proposed over the last thirty years, many of which are based on geometric graphs. These include, among several others, the celebrated Friedman-Rafsky two-sample test based on the minimal spanning tree and the K-nearest neighbor graphs, and the Bickel-Breiman spacings tests for goodness-of-fit. These tests are asymptotically distribution-free, universally consistent, and computationally efficient (both in sample size and in dimension), making them particularly attractive for modern statistical applications.

In this talk, we will derive the detection thresholds and limiting local power of these tests, thus providing a way to compare and justify the performance of these tests in various applications. Several interesting properties emerge, such as a curious phase transition in dimension 8, and a remarkable blessing of dimensionality in detecting scale changes.

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Workshop / Seminar Fri, 31 Jan 2020 16:34:15 -0500 2020-02-21T10:00:00-05:00 2020-02-21T11:00:00-05:00 West Hall Department of Statistics Workshop / Seminar Bhattacharya
Economics at Work (February 21, 2020 1:00pm) https://events.umich.edu/event/71144 71144-17783443@events.umich.edu Event Begins: Friday, February 21, 2020 1:00pm
Location: Lorch Hall
Organized By: Department of Economics

Economics@Work is intended for any student who is interested in learning about a variety of career opportunities for economics majors. Early students of economics may use this class to explore whether an economics major best suits their interests and goals. Advanced students in economics will benefit from the information and networking opportunities.

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Workshop / Seminar Thu, 09 Jan 2020 10:59:43 -0500 2020-02-21T13:00:00-05:00 2020-02-21T14:10:00-05:00 Lorch Hall Department of Economics Workshop / Seminar Economics
Defining microRNAs: How Cells Select Transcripts to Enter the microRNA pathway- Department of Biological Chemistry Seminar (February 25, 2020 12:00pm) https://events.umich.edu/event/71136 71136-17783434@events.umich.edu Event Begins: Tuesday, February 25, 2020 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Wenwen Fang, Postdoctoral Fellow at Whitehead/MIT will be presenting the Department of Biological Chemistry Seminar on Tuesday February 25th, 2020 at 12:00pm in North Lecture Hall, MS II.

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Workshop / Seminar Thu, 09 Jan 2020 06:47:39 -0500 2020-02-25T12:00:00-05:00 2020-02-25T13:00:00-05:00 Medical Science Unit II Biological Chemistry Workshop / Seminar
DS/CSS Seminar Series: Ashwin Rajadesingan (February 27, 2020 12:00pm) https://events.umich.edu/event/73244 73244-18181858@events.umich.edu Event Begins: Thursday, February 27, 2020 12:00pm
Location: North Quad
Organized By: School of Information

PhD candidate Ashwin Rajadesingan will discuss two ongoing approaches to depolarize online political discussions: Can priming a superordinate identity such as the American national identity improve conversation quality between partisans? Does individuating users to see beyond partisan identities or highlighting shared social identities improve political discussions online?

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Workshop / Seminar Mon, 24 Feb 2020 15:09:09 -0500 2020-02-27T12:00:00-05:00 2020-02-27T13:00:00-05:00 North Quad School of Information Workshop / Seminar Ashwin Rajadesingan
BME 500: Kelly Stevens (February 27, 2020 4:00pm) https://events.umich.edu/event/70067 70067-17505693@events.umich.edu Event Begins: Thursday, February 27, 2020 4:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

The notion of building artificial human organs has moved from a far-fetched concept to the forefront of regenerative medicine research. While progress is being made, most tissues created to date are simply not large enough to support clinically meaningful functions, and their structural features remain an magnitude coarser in resolution than native tissues. Few organs better represent this challenge than the liver – the largest visceral organ in the human body, in which hepatocytes are aligned in single cell-width structures entangled with vascular and biliary networks. To address this challenge, we are working to develop a portfolio of tools that integrate 3D printing, synthetic biology, and the innate capacity of cells to self-assemble. We are applying these tools to decode the signals that drive tissue assembly during development, and using this information to build scaled artificial tissues that replicate the features of native tissues.

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Workshop / Seminar Thu, 20 Feb 2020 11:04:16 -0500 2020-02-27T16:00:00-05:00 2020-02-27T17:00:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar BME Event
Control of electromagnetic fields for energy applications (February 28, 2020 11:00am) https://events.umich.edu/event/72340 72340-17974691@events.umich.edu Event Begins: Friday, February 28, 2020 11:00am
Location: Electrical Engineering and Computer Science Building
Organized By: Electrical and Computer Engineering

Abstract

Electromagnetic fields represent a fundamental aspect of nature, and serve as the primary carrier of energy. New abilities to control electromagnetic fields, as enabled for example by the developments of metamaterials and nanophotonic structures, can therefore have profound implications for energy technology. In this talk we will discuss some of our recent efforts in applying the concepts of electromagnetics towards developing new energy technologies, with examples including radiative cooling, and robust dynamic wireless power transfer.

Bio

Shanhui Fan is a Professor of Electrical Engineering, a Professor of Applied Physics (by courtesy), a Senior Fellow of the Precourt Institute for Energy, and the Director of the Edward L. Ginzton Laboratory, at the Stanford University. He received his Ph. D in 1997 in theoretical condensed matter physics from the Massachusetts Institute of Technology (MIT). His research interests are in fundamental studies of solid state and photonic structures and devices, especially photonic crystals, plasmonics, and meta-materials, and applications of these structures in energy and information technology applications. He has published over 500 refereed journal articles, has given over 350 plenary/keynote/invited talks, and was granted 62 US patents. Prof. Fan received a National Science Foundation Career Award (2002), a David and Lucile Packard Fellowship in Science and Engineering (2003), the National Academy of Sciences W. O. Baker Award for Initiative in Research (2007), the Adolph Lomb Medal from the Optical Society of America (2007), and a Vannevar Bush Faculty Fellowship from the U. S. Department of Defense (2017). He is a Thomson Reuters Highly Cited Researcher in Physics since 2015, a Fellow of the IEEE, the American Physical Society, the Optical Society of America, and the SPIE.

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Lecture / Discussion Fri, 31 Jan 2020 14:47:26 -0500 2020-02-28T11:00:00-05:00 2020-02-28T12:00:00-05:00 Electrical Engineering and Computer Science Building Electrical and Computer Engineering Lecture / Discussion Electrical Engineering and Computer Science Building
MFG Research Seminar: Democratizing Advanced Manufacturing (February 28, 2020 11:00am) https://events.umich.edu/event/72739 72739-18070545@events.umich.edu Event Begins: Friday, February 28, 2020 11:00am
Location: Chrysler Center
Organized By: Integrative Systems + Design

Abstract
The technological foundations of advanced manufacturing continue to rapidly evolve as ubiquitous sensing, cloud computing and storage, and next generation controllers are introduced into the manufacturing ecosystem. This talk presents some of the technical concepts and business models that will enable new technologies and capabilities in the manufacturing sector to be rapidly deployed throughout the U.S. industrial base. Insight will be presented into next generation resilient production operations and business models that favor local and point of assembly manufacturing. The talk will conclude with a discussion of how rapidly advancing technical innovations will be propagated throughout the manufacturing enterprise, ensuring a state-of-the-art manufacturing economy. This will provide opportunities for businesses of all sizes and democratize advanced manufacturing technologies throughout the United States.

Speaker Bio
Thomas Kurfess is the Chief Manufacturing Officer for Oak Ridge National Laboratory (ORNL). In this position he is responsible for the strategic planning for advanced Manufacturing. His research focuses on the design and development of advanced systems by rapidly developing, scaling and integrating new technologies into production operations. Prior to joining ORNL, he was Professor of Mechanical Engineering and the HUSCO Ramirez Distinguished Chair in Fluid Power and Motion Control. Kurfess has also served as the Assistant Director for Advanced Manufacturing at the Office of Science and Technology Policy in the Executive Office of the President of the United States of America. In this position, he had responsibility for engaging the federal sector and the greater scientific community to identify possible areas for policy actions related to manufacturing. He earned his PhD, SM and SB in mechanical engineering, and an SM in Electrical Engineering and Computer Science from the Massachusetts Institute of Technology.

Co-organized by:
Judy Jin (Program Director, ISD Manufacturing;Professor IOE)
Chinedum Okwudire (Associate Chair, ISD; Associate Professor, ME)

Questions?
Contact Kathy Bishar at kbishar@umich.edu

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Workshop / Seminar Tue, 11 Feb 2020 13:10:37 -0500 2020-02-28T11:00:00-05:00 2020-02-28T12:00:00-05:00 Chrysler Center Integrative Systems + Design Workshop / Seminar Tom Kurfess Photo
Cryo-EM Studies of Molecular Motors and Their Associated Filamentous Assemblies- Department of Biological Chemistry Semianr (March 3, 2020 12:00pm) https://events.umich.edu/event/72842 72842-18085912@events.umich.edu Event Begins: Tuesday, March 3, 2020 12:00pm
Location: Medical Science Unit II
Organized By: Biological Chemistry

Dr. Charles Sindelar, Associate Professor of Molecular Biochemistry and Biophysics at Yale School of Medicine will be presenting the Department of Biological Chemistry Seminar on Tuesday March 3rd, 2020 at 12 noon in North Lecture Hall, MS II.

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Workshop / Seminar Thu, 13 Feb 2020 08:27:58 -0500 2020-03-03T12:00:00-05:00 2020-03-03T13:00:00-05:00 Medical Science Unit II Biological Chemistry Workshop / Seminar Sindelar Flyer
Great Lakes Seminar Series (March 3, 2020 1:00pm) https://events.umich.edu/event/73185 73185-18155745@events.umich.edu Event Begins: Tuesday, March 3, 2020 1:00pm
Location: Off Campus Location
Organized By: Cooperative Institute for Great Lakes Research (CIGLR)

Please join us for a Great Lakes Seminar Series presentation!
Date: Tuesday, March 3
Time: 1:00-2:00 pm EDT
Attend In-Person: NOAA Great Lakes Environmental Research Laboratory, Lake Superior Hall* (Directions)
Attend Remotely: https://attendee.gotowebinar.com/register/4302585117583410187

Presenter: Maureen Coleman, University of Chicago
Title: Linking microbial communities and biogeochemistry across the Laurentian Great Lakes

About the presentation: The Laurentian Great Lakes hold 20% of Earth’s surface freshwater and provide essential ecosystem services. Moreover, as an interconnected waterway that spans strong environmental gradients, the Great Lakes represent a unique natural laboratory for understanding how physical, chemical, and biological forces interact to shape microbial communities and biogeochemistry. Here we explore the drivers of microbial diversity and activity across the Great Lakes, using samples collected as part of an ongoing multi-year time series. First we characterized community composition across lakes, depths, seasons, and years. We found that depth and light are strong drivers of community structure in stratified water columns. Across surface waters, we found distinct microbial signatures in each of the Great Lakes, reflecting their biogeochemical variability. To explore metabolic functions, we reconstructed hundreds of microbial genomes and created a microbial tree of life for the Laurentian Great Lakes. We mapped ecological distribution patterns for these genomes and found distinct distributions for taxa and metabolisms across lakes and depths. We focus here on two important groups for ecology and biogeochemistry, the cyanobacteria and nitrifying Bacteria and Archaea. Our work represents the first picture of microbial diversity across the entire Laurentian Great Lakes and is an essential baseline from which to monitor future ecosystem change.

About the speaker: Dr. Coleman is an Assistant Professor in the Department of the Geophysical Sciences at the University of Chicago. She is a microbial ecologist who studies the causes and consequences of microbial diversity in aquatic systems. Currently her lab is busy characterizing microbial communities, genomic diversity, and biogeochemistry across the Laurentian Great Lakes. She is also cultivating new microbial lineages and developing genetic tools to study their biology. She holds an undergraduate degree in biology from Dartmouth College and a Ph.D. in Civil and Environmental Engineering from MIT. She was a postdoc at MIT & Caltech before joining the University of Chicago in 2012.

**Registration is not required to attend in-person, however please note important visitor information below**

Important Visitor Information
All in-person seminar attendees are required to receive a visitor badge from the front desk at the NOAA Great Lakes Environmental Research Laboratory facility. Seminar attendees need to present a valid U.S. photo ID or green card. If you are a Foreign National, advance notification of at least 48 hours is needed so that security guidelines are followed. You will need to present your passport (a copy will NOT work). For questions regarding building access, or assistance in obtaining Foreign National clearance, please call 734-741-2394. Email contact: Scott.Purdy@noaa.gov
_____________________________________________________
Questions? Contact Mary Ogdahl: ogdahlm@umich.edu
Visit ciglr.seas.umich.edu for more information.

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Presentation Fri, 21 Feb 2020 16:13:30 -0500 2020-03-03T13:00:00-05:00 2020-03-03T14:00:00-05:00 Off Campus Location Cooperative Institute for Great Lakes Research (CIGLR) Presentation Great Lakes Seminar Series Flyer
Public Finance Seminar (March 5, 2020 4:00pm) https://events.umich.edu/event/73620 73620-18269848@events.umich.edu Event Begins: Thursday, March 5, 2020 4:00pm
Location: Lorch Hall
Organized By: Department of Economics

Details to come.

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Workshop / Seminar Thu, 05 Mar 2020 16:21:33 -0500 2020-03-05T16:00:00-05:00 2020-03-05T17:00:00-05:00 Lorch Hall Department of Economics Workshop / Seminar economics
Social, Behavioral & Experimental Economics (SBEE): Understanding Cultural Persistence and Change (March 9, 2020 11:45am) https://events.umich.edu/event/71228 71228-18304808@events.umich.edu Event Begins: Monday, March 9, 2020 11:45am
Location: Ross School of Business
Organized By: Department of Economics

Abstract:
We examine a determinant of cultural persistence that has emerged from a class of models in evolutionary anthropology: the similarity of the environment across generations. Within these models, when the environment is more similar across generations, the traits that have evolved up to the previous generation are more likely to be optimal for the current generation. In equilibrium, a greater value is placed on tradition and there is greater cultural persistence. We test this hypothesis by measuring the variability of different climatic measures across 20-year generations from 500-1900. Employing a variety of tests, each using different samples and empirical strategies, we find that populations with ancestors who lived in environments with more cross-generational instability place less importance in maintaining tradition today and exhibit less cultural persistence.

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Workshop / Seminar Fri, 10 Jan 2020 10:53:44 -0500 2020-03-09T11:45:00-04:00 2020-03-09T12:45:00-04:00 Ross School of Business Department of Economics Workshop / Seminar Economics
Social, Behavioral & Experimental Economics (SBEE): Understanding Cultural Persistence and Change (March 9, 2020 12:00pm) https://events.umich.edu/event/71228 71228-18304809@events.umich.edu Event Begins: Monday, March 9, 2020 12:00pm
Location:
Organized By: Department of Economics

Abstract:
We examine a determinant of cultural persistence that has emerged from a class of models in evolutionary anthropology: the similarity of the environment across generations. Within these models, when the environment is more similar across generations, the traits that have evolved up to the previous generation are more likely to be optimal for the current generation. In equilibrium, a greater value is placed on tradition and there is greater cultural persistence. We test this hypothesis by measuring the variability of different climatic measures across 20-year generations from 500-1900. Employing a variety of tests, each using different samples and empirical strategies, we find that populations with ancestors who lived in environments with more cross-generational instability place less importance in maintaining tradition today and exhibit less cultural persistence.

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Workshop / Seminar Fri, 10 Jan 2020 10:53:44 -0500 2020-03-09T12:00:00-04:00 2020-03-09T13:00:00-04:00 Department of Economics Workshop / Seminar Economics
Public Finance & Labor Economics: PAY TRANSPARENCY AND THE GENDER GAP (March 9, 2020 4:00pm) https://events.umich.edu/event/67507 67507-16866613@events.umich.edu Event Begins: Monday, March 9, 2020 4:00pm
Location: Lorch Hall
Organized By: Department of Economics

Abstract:
We examine the impact of public sector salary disclosure laws on university faculty salaries in Canada. The laws, which enable public access to the salaries of individual faculty if they exceed specified thresholds, were introduced in different provinces at different times. Using detailed administrative data covering the majority of faculty in Canada, and an event-study research design that exploits within-province variation in exposure to the policy across institutions and academic departments, we find robust evidence that that the laws reduced the gender pay gap between men and women by approximately 30 percent. There is suggestive evidence that higher female salaries contributed to the narrowing of the gender gap. The reduction in the gender gap is primarily in universities where faculty are unionized.

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Workshop / Seminar Fri, 21 Feb 2020 10:02:20 -0500 2020-03-09T16:00:00-04:00 2020-03-09T17:30:00-04:00 Lorch Hall Department of Economics Workshop / Seminar economics
Epidemiology and dynamics of the coronavirus (COVID-19) epidemic (March 10, 2020 11:30am) https://events.umich.edu/event/73197 73197-18157926@events.umich.edu Event Begins: Tuesday, March 10, 2020 11:30am
Location: Weiser Hall
Organized By: The Center for the Study of Complex Systems

The novel coronavirus COVID-19 epidemic is currently leveling off in China but on the upswing in the rest of the world. Understanding and modeling this growth is obviously of high importance. We noticed that for several weeks, the number of deaths in China could be fit by a power law with exponent of about 2.25, suggesting a kind of fractal or small-world behavior going on. Traditional epidemiological models, such as the Susceptible-Exposed-Infected-Recovered models (SEIR) puts groups in compartments and use differential equations to predict the behavior, but there is no spatial or network properties taken into account. At early times, the growth is exponential depending upon the reproduction rate, and for later times those models predict an s-shaped curve. The power-law result predicted a greater growth of the epidemic than many people were predicting. More recently, the daily deaths in China have dropped off exponentially, in fact following a model of A. Vazquez from 2006. At the same time, the growth in the number of total deaths in other parts of the world is tracking the behavior in China, delayed by one month. The small-world, fractal idea suggested that this world-wide transmission was likely to take place, and the belief that it could be contained in China was clearly short-sighted.

Reference: A. L. Ziff and R. M. Ziff, medrXiv 2020 submitted.

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Workshop / Seminar Tue, 03 Mar 2020 23:51:52 -0500 2020-03-10T11:30:00-04:00 2020-03-10T13:00:00-04:00 Weiser Hall The Center for the Study of Complex Systems Workshop / Seminar Robert Ziff
MCDB Dissertation Defense: "Molecular Mechanisms of Golgi Structure Alterations during Stress” (March 10, 2020 2:00pm) https://events.umich.edu/event/72769 72769-18070599@events.umich.edu Event Begins: Tuesday, March 10, 2020 2:00pm
Location: Rackham Graduate School (Horace H.)
Organized By: Department of Molecular, Cellular, and Developmental Biology

Mentor: Y. Wang

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Workshop / Seminar Mon, 09 Mar 2020 15:49:26 -0400 2020-03-10T14:00:00-04:00 2020-03-10T16:00:00-04:00 Rackham Graduate School (Horace H.) Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials & microscope drawing in yellow on a blue square
Statistics Department Seminar Series: Jimmy de la Torre, Professor, Human Communication, Development, and Information Sciences, University of Hong Kong (March 10, 2020 4:00pm) https://events.umich.edu/event/73305 73305-18190739@events.umich.edu Event Begins: Tuesday, March 10, 2020 4:00pm
Location: West Hall
Organized By: Department of Statistics

Abstract:
At present, many educational researchers and practitioners are highly interested in using educational assessment to improve student learning. However, it should be noted that assessment and learning can exist as two distinct components, and require a framework that would allow their integration into a single coherent system. The efficiency of such a system will depend on the extent that each component can be implemented adaptively. In this presentation, I will discuss using cognitive diagnosis modeling as a framework for developing a personalize assessment and learning system (PALS). I will discuss what cognitive diagnosis models (CDMs) are, what their unique features are, how they differ from other psychometric models, and how cognitive diagnosis computerized adaptive testing can further capitalize on the advantages of CDMs and make diagnostic testing more efficient. To build the complete PALS, an explicit instructional component that can facilitate learning is needed. I will discuss a number of important issues that need to addressed before a coherent and effective PALS can be built. The presentation will conclude with a discussion of possible future directions, and some of the challenges and recent developments in the area.

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Workshop / Seminar Tue, 25 Feb 2020 17:18:51 -0500 2020-03-10T16:00:00-04:00 2020-03-10T17:00:00-04:00 West Hall Department of Statistics Workshop / Seminar Jimmy de la Torre
CANCELED: MIPSE Seminar | Rethinking the Art of Plasma Etch (March 11, 2020 3:30pm) https://events.umich.edu/event/70792 70792-17644317@events.umich.edu Event Begins: Wednesday, March 11, 2020 3:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Michigan Institute for Plasma Science and Engineering (MIPSE)

Abstract:
Since the 1970s, the semiconductor industry has fabricated electronic circuits using a plasma based pattern-transfer ap-proach that is remarkably reminiscent of the etching artform used centuries ago. Only now, the patterns are a million times smaller and driven by the wafer fab equipment industry. The most advanced plasma etching technique in production today is called atomic layer etching (ALE) in which a single layer is removed in a cyclic manner. This talk will review the ALE ap-proach in comparison to conventional plasma etching tech-niques, such as Reactive Ion Etching (RIE). As RIE reaches its fifth decade, its drawbacks have become apparent. ALE offers better control by isolating steps in time and switching between the steps in a repeatable cycle. To the extent that an ALE pro-cess behaves ideally – with high ALE synergy and self-limiting behavior – the primary benefit is improved uniformity across all length scales: at the surface, between different aspect rati-os, and across the full wafer. Another benefit that will be high-lighted is the atomic-scale smoothness in topography of the surface left behind after etching. The underlying mechanism and benefits of plasma ALE will be described, providing insight into the plasma science behind the ancient art of etching. Overall, ALE is simpler to understand than conventional plasma etch processing, and is proving to be important as we apply the art of etch at the atomic scale.

About the Speaker:
Richard A. Gottscho is Executive VP, Chief Technology Officer at Lam Research since May 2017. He previously was Executive VP, Global Products Group beginning August 2010; and group VP and general manager, Etch Businesses beginning March 2007. He joined Lam in January 1996 and has held various director and VP roles spanning deposition, etch, and clean products. Prior to joining Lam, he was at Bell Laboratories for 15 years, where he headed research departments in electronics materials, electronics packaging, and flat panel displays. In 2016, Dr. Gottscho was elected to the National Academy of Engineering. He has received several awards, including the AVS Peter Mark Me-morial Award, AVS Plasma Science and Technology Division Prize, the Dry Process Symposium Nishiza-wa Award, and the Tegal Thinker Award. He is a fellow of the APS and AVS. He has authored numerous papers, patents, and lectures, and has served on journal editorial boards and program committees for major conferences in plasma science and engineering. He served as vice-chair of a National Research Council study on plasma science. Dr. Gottscho earned Ph.D. and B.S. degrees in physical chemistry from the Massachusetts Institute of Technology and Pennsylvania State University, respectively.

The seminar will be web-simulcast. To view the simulcast, please follow this link:
https://mipse.my.webex.com/mipse.my/j.php?MTID=m470378ee7563bc37fae0bcbb395a7d98
Meeting number: 624 374 412
Password: MIPSE2019

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Lecture / Discussion Sat, 07 Mar 2020 09:20:03 -0500 2020-03-11T15:30:00-04:00 2020-03-11T16:30:00-04:00 Electrical Engineering and Computer Science Building Michigan Institute for Plasma Science and Engineering (MIPSE) Lecture / Discussion Rick Gottscho
DCMB Weekly Seminar (March 11, 2020 4:00pm) https://events.umich.edu/event/73002 73002-18123077@events.umich.edu Event Begins: Wednesday, March 11, 2020 4:00pm
Location:
Organized By: DCMB Seminar Series

Abstract:

In this talk, some major challenges are reviewed of using Artificial Intelligence (AI) to address the needs of medicine and healthcare. These challenges include technical issues such as data-related and/or algorithmic challenges that the use of AI for medicine would present. The speaker then presents some potential solutions in form of novel algorithmic approaches that may at least partially address some of these challenges.

BlueJeans livestream: https://primetime.bluejeans.com/a2m/live-event/rbuvycdc

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Lecture / Discussion Wed, 11 Mar 2020 08:49:28 -0400 2020-03-11T16:00:00-04:00 2020-03-11T17:00:00-04:00 DCMB Seminar Series Lecture / Discussion
Witness Lab Simulation: Salem Witch Trials with Professor Leonard Niehoff's U-M Law Seminar (March 11, 2020 5:30pm) https://events.umich.edu/event/70546 70546-17604939@events.umich.edu Event Begins: Wednesday, March 11, 2020 5:30pm
Location: Museum of Art
Organized By: University of Michigan Museum of Art (UMMA)

Professor Len Niehoff will lead a U-M Law School seminar discussion of the Salem Witch Trials with twelve students before a public audience. The March 11 session will focus on the history of the trials and the legal issues they raise. The March 18 session will include live performances of actual parts of the trials, along with conversation about the lessons they convey. Professor Niehoff has a forthcoming article on the witch trials and is working on a book about them as well. ​Come get a glimpse into both a law school classroom and a 1692 colonial witch trial!

Witness Lab is presented in partnership with the Roman J. Witt Artist in Residence Program of the Penny W. Stamps School of Art & Design, with lead support provided by the University of Michigan Law School and Office of the Provost.

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Presentation Tue, 03 Mar 2020 18:17:02 -0500 2020-03-11T17:30:00-04:00 2020-03-11T19:30:00-04:00 Museum of Art University of Michigan Museum of Art (UMMA) Presentation Museum of Art
Witness Lab Simulation: Salem Witch Trials with Professor Leonard Niehoff's U-M Law Seminar​ (March 11, 2020 5:30pm) https://events.umich.edu/event/73682 73682-18280818@events.umich.edu Event Begins: Wednesday, March 11, 2020 5:30pm
Location: Museum of Art
Organized By: University of Michigan Museum of Art (UMMA)

This class interaction with the Witness Lab project is open to the public for observation. Seating is limited. Visit our Witness Lab page for an ever-evolving list of opportunities to see the Witness Lab project in action. 

Designed as a courtroom installation and a performance series by Roman J. Witt Artist in Residence Courtney McClellan, Witness Lab frames witnessing as a social and artistic act. The gallery collapses courtroom, theater, classroom, laboratory, and artist studio in order to study the relationship between performance and law. Public programs, classes, and mock trial performances investigate who plays the role of the witness in our society, and help us to understand truth within our legal system.

In her investigation of America’s courts, McClellan’s practice engages K-12 and university classes across a spectrum of disciplines including law, drama, and anthropology, among others. 

Due to the nature of the project, the schedule for all Witness Lab events and simulations are subject to change without notice and changes may not always be reflected in online listings.

Witness Lab is presented in partnership with the Roman J. Witt Artist in Residence Program of the Penny W. Stamps School of Art & Design, with lead support provided by the University of Michigan Law School and Office of the Provost.

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Lecture / Discussion Fri, 06 Mar 2020 18:17:22 -0500 2020-03-11T17:30:00-04:00 2020-03-11T19:30:00-04:00 Museum of Art University of Michigan Museum of Art (UMMA) Lecture / Discussion Museum of Art
BME 500: Rebecca Wachs (March 12, 2020 4:00pm) https://events.umich.edu/event/70068 70068-17505695@events.umich.edu Event Begins: Thursday, March 12, 2020 4:00pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

The majority of the population will experience low back pain in their lifetime. Degeneration of the intervertebral disc is highly correlated with low back pain, however, not all disc degeneration is painful. One of the most common forms of low back pain is disc-associated low back pain in which pain originates from intervertebral disc. In disc-associated low back pain, nerve fibers penetrate the previously aneural disc, where they are then thought to be stimulated by the harsh catabolic environment. Repetitive stimulation of these nerve fibers can cause sensitization and chronic pain. The overarching goal of our work is to engineer biomaterials that target these two key areas of disc-associated low back pain: nerve growth and stimulation. Current clinical treatments for chronic low back pain have limited efficacy or are highly invasive. The majority of research to date focuses on regenerating a young healthy disc. We believe our approach to target nerve growth and stimulation independent of disc regeneration has the potential shift the paradigm in the treatment of low back pain.

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Workshop / Seminar Tue, 10 Mar 2020 11:43:59 -0400 2020-03-12T16:00:00-04:00 2020-03-12T17:00:00-04:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar BME Event
Canceled: Statistics Department Seminar Series: Daniel Almirall, Research Associate Professor, Survey Research Center, Institute for Social Research and Research Associate Professor of Statistics (by courtesy), University of Michigan (March 13, 2020 10:00am) https://events.umich.edu/event/69920 69920-17483052@events.umich.edu Event Begins: Friday, March 13, 2020 10:00am
Location: West Hall
Organized By: Department of Statistics

"Assessing Proximal Causal Effects on a Binary Outcome using Data from a Micro-randomized Trial: Case Study Design and Analysis"
Abstract

Emerging mobile health interventions aim to provide support whenever and wherever it is needed. This includes the provision of therapeutic support in (near) real time, as well as the provision of prompts that support the engagement of users in the mobile health application. A micro-randomized trial (MRT) is a new trial design that is useful for addressing scientific questions concerning the construction of mobile health applications of this type.  This talk describes the design and analysis of a micro-randomized trial conducted in collaboration with a local digital behavioral health company based in Ann Arbor. The purpose of the MRT was to (i) test the effectiveness of using a “push” prompt to engage users with a smartphone-based mobile health application, and (ii) to estimate whether the effectiveness of the prompt depends on the time at which the prompt is sent, as well as a prespecified set of user characteristics and other contextual factors. The trial’s primary outcome was binary, namely, whether or not the user engaged with the smartphone app over the next 24 hours. To analyze the data arising from this MRT, we developed a new approach to estimating the proximal causal effects that could accommodate a binary outcome. We describe the design of the MRT, the new data analysis method, and the results.
An explicit goal of this talk is to provide a friendly introduction to some of the ideas underlying the design and analysis of MRTs, as opposed to focusing on technical details of the method.

This is joint work with Susan A. Murphy, Inbal Nahum-Shani and Niranjan Bidargarddi.

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Workshop / Seminar Thu, 12 Mar 2020 09:41:05 -0400 2020-03-13T10:00:00-04:00 2020-03-13T11:00:00-04:00 West Hall Department of Statistics Workshop / Seminar Almirall,Daniel
CANCELED: Mechanisms Linking Cell Mechanics and Metabolism (March 13, 2020 12:00pm) https://events.umich.edu/event/72757 72757-18070590@events.umich.edu Event Begins: Friday, March 13, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Ann Miller

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Workshop / Seminar Tue, 10 Mar 2020 11:32:19 -0400 2020-03-13T12:00:00-04:00 2020-03-13T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar microscope drawing, MCDB initials in yellow on blue background
CANCELED: Organization of cellular fat store . . . (March 17, 2020 12:00pm) https://events.umich.edu/event/72758 72758-18070591@events.umich.edu Event Begins: Tuesday, March 17, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

This seminar has been cancelled.

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Workshop / Seminar Tue, 10 Mar 2020 10:50:42 -0400 2020-03-17T12:00:00-04:00 2020-03-17T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials and yellow microscope drawing on a blue square
Witness Lab Simulation: Salem Witch Trials with Professor Leonard Niehoff's U-M Law Seminar (March 18, 2020 5:30pm) https://events.umich.edu/event/70550 70550-17604943@events.umich.edu Event Begins: Wednesday, March 18, 2020 5:30pm
Location: Museum of Art
Organized By: University of Michigan Museum of Art (UMMA)

Professor Len Niehoff will lead a U-M Law School seminar discussion of the Salem Witch Trials with twelve students before a public audience. The March 11 session will focus on the history of the trials and the legal issues they raise. The March 18 session will include live performances of actual parts of the trials, along with conversation about the lessons they convey. Professor Niehoff has a forthcoming article on the witch trials and is working on a book about them as well. ​Come get a glimpse into both a law school classroom and a 1692 colonial witch trial!

Witness Lab is presented in partnership with the Roman J. Witt Artist in Residence Program of the Penny W. Stamps School of Art & Design, with lead support provided by the University of Michigan Law School and Office of the Provost.

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Presentation Thu, 12 Mar 2020 18:17:04 -0400 2020-03-18T17:30:00-04:00 2020-03-18T19:30:00-04:00 Museum of Art University of Michigan Museum of Art (UMMA) Presentation Museum of Art
Livestream: Statistics Department Seminar Series: Professor Edward Ionides, Department of Statistics, University of Michigan (March 20, 2020 10:00am) https://events.umich.edu/event/73856 73856-18367048@events.umich.edu Event Begins: Friday, March 20, 2020 10:00am
Location:
Organized By: Department of Statistics

Abstract:

Infectious disease transmission is a nonlinear partially observed stochastic dynamic system with topical interest. For low-dimensional systems, models can be fitted to time series data using Monte Carlo particle filter methods. As dimension increases, for example when analyzing epidemics among a collection of spatially coupled populations, particle filter methods rapidly degenerate. We show that many independent Monte Carlo calculations, each of which does not attempt to solve the filtering problem, can be combined to give a global filtering solution with favorable theoretical scaling properties under a weak coupling condition. The independent Monte Carlo calculations are called islands, and the operation carried out on each island is called adapted simulation, so the complete algorithm is called an adapted simulation island filter. We demonstrate this methodology and some related algorithms on a model for measles transmission within and between cities. The COVID-19 situation will also be discussed.

This seminar will be livestreamed and is accessible at
https://umich.zoom.us/j/252293050
Problems? Email stat-phd-council-seminar+streaming@umich.edu

A virtual reception will follow and is accessible at
https://umich.zoom.us/j/496003846
Note: The virtual reception will begin shortly after the seminar livestream has concluded.

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Workshop / Seminar Fri, 20 Mar 2020 09:54:09 -0400 2020-03-20T10:00:00-04:00 2020-03-20T11:00:00-04:00 Department of Statistics Workshop / Seminar Ionides
Canceled: Shaping the cell from the outside in (March 20, 2020 12:00pm) https://events.umich.edu/event/72760 72760-18070592@events.umich.edu Event Begins: Friday, March 20, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Anthony Vecchiarelli

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Workshop / Seminar Tue, 10 Mar 2020 14:55:11 -0400 2020-03-20T12:00:00-04:00 2020-03-20T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials & microscope drawing in yellow on a blue square
Livestream: Workshop on Variational Bayes Presented by Tamara Broderick, Associate Professor, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology (March 26, 2020 9:00am) https://events.umich.edu/event/73937 73937-18432935@events.umich.edu Event Begins: Thursday, March 26, 2020 9:00am
Location: Off Campus Location
Organized By: Department of Statistics

Abstract:

Bayesian methods exhibit a number of desirable properties for modern data analysis---including (1) coherent quantification of uncertainty, (2) a modular modeling framework able to capture complex phenomena, (3) the ability to incorporate prior information from an expert source, and (4) interpretability. In practice, though, Bayesian inference necessitates approximation of a high-dimensional integral, and some traditional algorithms for this purpose can be slow---notably at data scales of current interest. The tutorial will cover the foundations of some modern tools for fast, approximate Bayesian inference at scale. One increasingly popular framework is provided by "variational Bayes" (VB), which formulates Bayesian inference as an optimization problem. We will examine key benefits and pitfalls of using VB in practice, with a focus on the widespread "mean-field variational Bayes" (MFVB) subtype. We will highlight properties that anyone working with VB, from the data analyst to the theoretician, should be aware of. And we will discuss a number of open challenges.

This workshop is open to all and will be livestreamed at
https://umich.zoom.us/j/610377170
Problems? Email stat-phd-council-seminar+streaming@umich.edu

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Lecture / Discussion Tue, 24 Mar 2020 11:47:41 -0400 2020-03-26T09:00:00-04:00 2020-03-26T12:00:00-04:00 Off Campus Location Department of Statistics Lecture / Discussion Workshop Flyer
BME 500: Zach Danziger (March 26, 2020 4:00pm) https://events.umich.edu/event/70071 70071-17507736@events.umich.edu Event Begins: Thursday, March 26, 2020 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: Online hosting procedure TBD.

Therapeutic and Reparative Neurotechnology

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Workshop / Seminar Mon, 23 Mar 2020 14:23:16 -0400 2020-03-26T16:00:00-04:00 2020-03-26T17:00:00-04:00 Off Campus Location Biomedical Engineering Workshop / Seminar BME Event
Livestream: Statistics Department Seminar Series: Tamara Broderick, Associate Professor, Department Electrical Engineering and Computer Science, Massachusetts Institute of Technology (March 27, 2020 10:00am) https://events.umich.edu/event/69922 69922-18432932@events.umich.edu Event Begins: Friday, March 27, 2020 10:00am
Location: Off Campus Location
Organized By: Department of Statistics

Abstract:
Discovering interaction effects on a response of interest is a fundamental problem in biology, medicine, economics, and many other scientific disciplines. In theory, Bayesian methods for discovering pairwise interactions enjoy many benefits such as coherent uncertainty quantification, the ability to incorporate background knowledge, and desirable shrinkage properties. In practice, however, Bayesian methods are often computationally intractable for even moderate-dimensional problems. Our key insight is that many hierarchical models of practical interest admit a particular Gaussian process (GP) representation; the GP allows us to capture the posterior with a vector of O(p) kernel hyper-parameters rather than O(p^2) interactions and main effects. With the implicit representation, we can run Markov chain Monte Carlo (MCMC) over model hyper-parameters in time and memory linear in p per iteration. We focus on sparsity-inducing models and show on datasets with a variety of covariate behaviors that our method: (1) reduces runtime by orders of magnitude over naive applications of MCMC, (2) provides lower Type I and Type II error relative to state-of-the-art LASSO-based approaches, and (3) offers improved computational scaling in high dimensions relative to existing Bayesian and LASSO-based approaches.
*Livestream Info*
This Seminar will be livestreamed using Zoom. When you click the meeting link on your PC or mobile device, it will direct you to the Zoom app (which you may wish to download in advance).

You will be able to see/hear the presenter, but your microphone/camera are off. If you’d like to ask a question at any time, please click the hand icon to “raise your hand” and a moderator can temporarily enable your microphone so you can ask a question and interact with the presenter. You can also use the Q&A feature to submit typed questions if you prefer.

Join from Computer/Tablet/Smartphone
Please click the link below to join the webinar:
https://umich.zoom.us/j/402943422

Join via Phone
iPhone one-tap :
US: +13126266799,,402943422# or +16468769923,,402943422#
Or Telephone:
Dial(for higher quality, dial a number based on your current location):
US: +1 312 626 6799 or +1 646 876 9923 or +1 346 248 7799 or +1 669 900 6833 or +1 253 215 8782 or +1 301 715 8592
Canada: +1 647 558 0588 or +1 778 907 2071 or +1 438 809 7799 or +1 587 328 1099 or +1 647 374 4685
Webinar ID: 402 943 422
International numbers available: https://umich.zoom.us/u/ac83BV4NUh

Virtual Reception:
Reception goes live several minutes after seminar concludes:
https://umich.zoom.us/j/496003846

If you encounter problems, you can email stat-phd-council-seminar+streaming@umich.edu and we will do our best to assist you.

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Workshop / Seminar Tue, 24 Mar 2020 09:27:41 -0400 2020-03-27T10:00:00-04:00 2020-03-27T11:00:00-04:00 Off Campus Location Department of Statistics Workshop / Seminar Broderick
CANCELED Coatopathies: Genetic Disorders of Protein Coat (March 27, 2020 12:00pm) https://events.umich.edu/event/72762 72762-18070593@events.umich.edu Event Begins: Friday, March 27, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Ming Li

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Workshop / Seminar Tue, 10 Mar 2020 10:49:33 -0400 2020-03-27T12:00:00-04:00 2020-03-27T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials & microscope drawing in yellow on a blue square
The Beattie Family Seminar Series in Combat Casualty Care (March 30, 2020 3:00pm) https://events.umich.edu/event/71949 71949-17903307@events.umich.edu Event Begins: Monday, March 30, 2020 3:00pm
Location: North Campus Research Complex Building 10
Organized By: Michigan Center for Integrative Research in Critical Care (MCIRCC)

Carol Ann Fausone graduated from the University of Michigan School of Nursing in 1975. General Fausone served her country for 36 years retiring in 2011. From 2003-2011 she served as the Assistant Adjutant General of Veterans Affairs, for the Department of Military and Veterans Affairs, State of Michigan advocating for Veterans. From 2001-2005, General Fausone served as the Assistant for Mobilization and Reserve Affairs working directly with the Deputy Assistant Secretary of Defense for Health Affairs, Force Health Protection and Readiness. Serving in this capacity, she assisted in developing and implementing programs, policy, and operations for Reserve Affairs.

Carol Ann continues serving by “Taking Care of Our American Heroes and their Families” to obtain the benefits they deserve at Legal Help for Veterans.

DETAILS & REGISTRATION:
http://bit.ly/CarolAnnFausone

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Workshop / Seminar Thu, 23 Jan 2020 12:01:20 -0500 2020-03-30T15:00:00-04:00 2020-03-30T16:00:00-04:00 North Campus Research Complex Building 10 Michigan Center for Integrative Research in Critical Care (MCIRCC) Workshop / Seminar The Beattie Family Seminar Series in Combat Casualty Care with Brigadier General Carol Ann Fausone (ret) Flyer
CANCELED: MIPSE Seminar | Journey to the Sun (April 1, 2020 3:30pm) https://events.umich.edu/event/70795 70795-17644320@events.umich.edu Event Begins: Wednesday, April 1, 2020 3:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Michigan Institute for Plasma Science and Engineering (MIPSE)

Abstract:
NASA Heliophysics research studies a vast system stretching from the Sun to Earth to far beyond the edge of the planets. Studying this system – much of it driven by the Sun’s constant outpouring of solar wind – not only helps us understand fundamental infor-mation about how the universe works, but also helps protect our technology and astronauts in space. NASA seeks knowledge of near-Earth space, because, when extreme, space weather can interfere with our com-munications, satellites and power grids. The study of the Sun and space can also teach us more about how stars contribute to the habitability of planets through-out the universe.
Mapping out this interconnected system requires a holistic study of the Sun’s influence on space, Earth and other planets. NASA has a fleet of spacecraft stra-tegically placed throughout our heliosphere – from Parker Solar Probe at the Sun observing the very start of the solar wind, to satellites around Earth, to the far-thest human-made object, Voyager, which is sending back observations on interstellar space. Each mission is positioned at a critical, well-thought out vantage point to observe and understand the flow of energy and particles throughout the solar system, and all helping us untagle the effects of the star we live with.

About the speaker:
Dr. Nicola Fox is the Heliophysics Division Director in the Science Mission Directorate at NASA Headquarters in Washington, DC. Until August 2018, Dr. Fox worked at the Applied Physics Lab at the Johns Hopkins University where she was the Chief Scientist for Heliophysics and the project scientist for NASA’s Parker Solar Probe. Dr. Fox served as the deputy project scientist for the Van Allen Probes, and the operations scientist for the International Solar Terrestrial Physics program. Fox received her BS in Physics and PhD in Space and Atmospheric Physics from the Imperial College of Science, Technology and Medicine in London. She received an MS in Telematics and Satellite Communications from the University of Surrey.

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Lecture / Discussion Wed, 18 Mar 2020 10:22:50 -0400 2020-04-01T15:30:00-04:00 2020-04-01T16:30:00-04:00 Electrical Engineering and Computer Science Building Michigan Institute for Plasma Science and Engineering (MIPSE) Lecture / Discussion Nicola Fox
BME 500: Alberto Figueroa (April 2, 2020 4:00pm) https://events.umich.edu/event/70072 70072-17507738@events.umich.edu Event Begins: Thursday, April 2, 2020 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be hosted via Blue Jeans. The link will be posted below.

Blue Jeans Link: https://umich.bluejeans.com/763221545

Dr. Figueroa received his PhD in Mechanical Engineering at Stanford University, where he developed computational methods fluid structure interaction simulation of hemodynamics.

His first academic appointment was a King’s College London in the UK, where he was Senior Lecturer in the Division of Biomedical Engineering and Imaging Sciences.

Dr. Figueroa is currently the Edward B. Diethrich M.D. Professor in Biomedical Engineering and Vascular Surgery at the University of Michigan. His laboratory is focused on three main areas: 1) developing tools for advanced modeling of blood flow. His group develops the modeling software CRIMSON (www.crimson.software); 2) studying the link between abnormal biomechanical stimuli and cardiovascular diseases such as hypertension and thrombosis; 3) simulation-based surgical planning to aid with the optimal planning of cardiovascular surgeries.

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Workshop / Seminar Wed, 01 Apr 2020 13:18:41 -0400 2020-04-02T16:00:00-04:00 2020-04-02T17:00:00-04:00 Off Campus Location Biomedical Engineering Workshop / Seminar BME Logo
CANCELED--Genomes gone wild: Experimental evolution meets synthetic biology (April 3, 2020 12:00pm) https://events.umich.edu/event/72765 72765-18070595@events.umich.edu Event Begins: Friday, April 3, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Andrzej Wierzbicki

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Workshop / Seminar Thu, 12 Mar 2020 08:59:45 -0400 2020-04-03T12:00:00-04:00 2020-04-03T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials microscope drawing on blue square
A Data Scientist Plays Games (April 3, 2020 3:00pm) https://events.umich.edu/event/74087 74087-18518836@events.umich.edu Event Begins: Friday, April 3, 2020 3:00pm
Location:
Organized By: Michigan Institute for Data Science

This event will be hosted online via Zoom

A Data Scientist Plays Games:  This is a presentation broken down into two parts.  The first is how to use mathematical techniques to analyze classic card and board games, and the second part is how data science techniques were applied in real life to support games on the Facebook platform.  This presentation is about 1.5 hours, with a target audience probably suited to CS/software engineering.  It’s light-hearted and fun.

Nick Berry, a native of the UK, has lived in Seattle for the last 25 years. He was educated as a rocket scientist and aircraft designer, graduating with a Masters Degree in Aeronautical and Astronautical Engineering.

Upon graduation, he joined a group of friends to form a software company, specializing in electronic mapping and route planning. This company was grown organically, and earned an unprecedented number of awards and accolades, including the British Design Award and The Queen’s Award for Technology, presented by Her Majesty in 1991. In 1994 Nick was recognized by the Sunday Times Magazine as “One of the top 50 entrepreneurs of the decade”. In 1994, after the company had grown to 50 people worldwide, it was sold to Microsoft.

Nick moved to America with the sale and spent 14 years working for Microsoft, the last ten of which were in the Microsoft Casual Game team. During his tenure, he filed a variety of patents for Microsoft, and represented Microsoft at various conferences and speaking engagements.

After leaving Microsoft, he joined RealNetworks to work as the GM of customer analytics for their games division, GameHouse.

After GameHouse, Nick spent five years as a Data Scientist, working for Facebook in their Seattle office.

In addition to his engineering expertise, Nick is passionate about data privacy and holds a CIPP qualification from the International Association of Privacy Professionals. He is an active member of the privacy community and speaks at various events about the legal and ethical aspects of data collection, use, and destruction.

In July 2013, Nick gave a TEDx talk about Passwords and the Internet, and in 2015 was nominated by GeekWire as Geek-of-the-week. In 2019 he was recognized as one of the 50 over 50 in the video games industry.

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Workshop / Seminar Mon, 06 Apr 2020 11:11:49 -0400 2020-04-03T15:00:00-04:00 2020-04-03T16:00:00-04:00 Michigan Institute for Data Science Workshop / Seminar Nick Berry
A Data Scientist Plays Games (April 3, 2020 3:00pm) https://events.umich.edu/event/74087 74087-18518837@events.umich.edu Event Begins: Friday, April 3, 2020 3:00pm
Location:
Organized By: Michigan Institute for Data Science

This event will be hosted online via Zoom

A Data Scientist Plays Games:  This is a presentation broken down into two parts.  The first is how to use mathematical techniques to analyze classic card and board games, and the second part is how data science techniques were applied in real life to support games on the Facebook platform.  This presentation is about 1.5 hours, with a target audience probably suited to CS/software engineering.  It’s light-hearted and fun.

Nick Berry, a native of the UK, has lived in Seattle for the last 25 years. He was educated as a rocket scientist and aircraft designer, graduating with a Masters Degree in Aeronautical and Astronautical Engineering.

Upon graduation, he joined a group of friends to form a software company, specializing in electronic mapping and route planning. This company was grown organically, and earned an unprecedented number of awards and accolades, including the British Design Award and The Queen’s Award for Technology, presented by Her Majesty in 1991. In 1994 Nick was recognized by the Sunday Times Magazine as “One of the top 50 entrepreneurs of the decade”. In 1994, after the company had grown to 50 people worldwide, it was sold to Microsoft.

Nick moved to America with the sale and spent 14 years working for Microsoft, the last ten of which were in the Microsoft Casual Game team. During his tenure, he filed a variety of patents for Microsoft, and represented Microsoft at various conferences and speaking engagements.

After leaving Microsoft, he joined RealNetworks to work as the GM of customer analytics for their games division, GameHouse.

After GameHouse, Nick spent five years as a Data Scientist, working for Facebook in their Seattle office.

In addition to his engineering expertise, Nick is passionate about data privacy and holds a CIPP qualification from the International Association of Privacy Professionals. He is an active member of the privacy community and speaks at various events about the legal and ethical aspects of data collection, use, and destruction.

In July 2013, Nick gave a TEDx talk about Passwords and the Internet, and in 2015 was nominated by GeekWire as Geek-of-the-week. In 2019 he was recognized as one of the 50 over 50 in the video games industry.

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Workshop / Seminar Mon, 06 Apr 2020 11:11:49 -0400 2020-04-03T15:00:00-04:00 2020-04-03T16:00:00-04:00 Michigan Institute for Data Science Workshop / Seminar Nick Berry
A Data Scientist Plays Games (April 3, 2020 3:00pm) https://events.umich.edu/event/74087 74087-18518838@events.umich.edu Event Begins: Friday, April 3, 2020 3:00pm
Location:
Organized By: Michigan Institute for Data Science

This event will be hosted online via Zoom

A Data Scientist Plays Games:  This is a presentation broken down into two parts.  The first is how to use mathematical techniques to analyze classic card and board games, and the second part is how data science techniques were applied in real life to support games on the Facebook platform.  This presentation is about 1.5 hours, with a target audience probably suited to CS/software engineering.  It’s light-hearted and fun.

Nick Berry, a native of the UK, has lived in Seattle for the last 25 years. He was educated as a rocket scientist and aircraft designer, graduating with a Masters Degree in Aeronautical and Astronautical Engineering.

Upon graduation, he joined a group of friends to form a software company, specializing in electronic mapping and route planning. This company was grown organically, and earned an unprecedented number of awards and accolades, including the British Design Award and The Queen’s Award for Technology, presented by Her Majesty in 1991. In 1994 Nick was recognized by the Sunday Times Magazine as “One of the top 50 entrepreneurs of the decade”. In 1994, after the company had grown to 50 people worldwide, it was sold to Microsoft.

Nick moved to America with the sale and spent 14 years working for Microsoft, the last ten of which were in the Microsoft Casual Game team. During his tenure, he filed a variety of patents for Microsoft, and represented Microsoft at various conferences and speaking engagements.

After leaving Microsoft, he joined RealNetworks to work as the GM of customer analytics for their games division, GameHouse.

After GameHouse, Nick spent five years as a Data Scientist, working for Facebook in their Seattle office.

In addition to his engineering expertise, Nick is passionate about data privacy and holds a CIPP qualification from the International Association of Privacy Professionals. He is an active member of the privacy community and speaks at various events about the legal and ethical aspects of data collection, use, and destruction.

In July 2013, Nick gave a TEDx talk about Passwords and the Internet, and in 2015 was nominated by GeekWire as Geek-of-the-week. In 2019 he was recognized as one of the 50 over 50 in the video games industry.

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Workshop / Seminar Mon, 06 Apr 2020 11:11:49 -0400 2020-04-03T15:00:00-04:00 2020-04-03T16:00:00-04:00 Michigan Institute for Data Science Workshop / Seminar Nick Berry
Webinar: 2020 MICDE Catalyst Grants Showcase (April 9, 2020 1:00pm) https://events.umich.edu/event/73858 73858-18367127@events.umich.edu Event Begins: Thursday, April 9, 2020 1:00pm
Location: Off Campus Location
Organized By: Michigan Institute for Computational Discovery and Engineering

This webinar will showcase some of the game-changing research supported by our Catalyst Grants program.

Session II Speakers:
Stephen Smith (Ecology and Evolutionary Biology), "Hierarchical computing for dynamic evolutionary inference of complexity;

Xun Huan (Mechanical Engineering), " Towards Bayesian uncertainty quantification in deep learning models for brain tumor segmentation;

and Monica Valluri (Astronomy), "Probing the nature of dark matter by modeling the Milky Way".

Join the Webinar (via BlueJeans Events)

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Livestream / Virtual Wed, 01 Apr 2020 09:17:00 -0400 2020-04-09T13:00:00-04:00 2020-04-09T14:30:00-04:00 Off Campus Location Michigan Institute for Computational Discovery and Engineering Livestream / Virtual MICDE
BME 500: Yannis Paulus (April 9, 2020 4:00pm) https://events.umich.edu/event/70074 70074-17507739@events.umich.edu Event Begins: Thursday, April 9, 2020 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: Online hosting procedure TBD.

Yannis M Paulus, MD, FACS, is a clinician scientist retina surgeon who directs a retinal optical imaging and laser lab. He is an Assistant Professor in the Department of Ophthalmology and Visual Sciences and Biomedical Engineering at the University of Michigan. He completed his undergraduate in chemistry and physics at Harvard University, medical school with a scholarly concentration in bioengineering and ophthalmology residency at Stanford University, and surgical and medical retina fellowship at Johns Hopkins University. His lab develops photoacoustic and molecular imaging of the retina and minimally traumatic retinal laser therapies. He has published over 90 peer-reviewed publications and started-up 3 companies to translate new technologies to patients to help treat and cure vision loss and blindness.

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Workshop / Seminar Mon, 06 Apr 2020 15:45:49 -0400 2020-04-09T16:00:00-04:00 2020-04-09T17:00:00-04:00 Off Campus Location Biomedical Engineering Workshop / Seminar BME Event
CANCELED: How do Fatty Acids Induce Mitochondrial H+ leak and Thermogenesis? (April 10, 2020 12:00pm) https://events.umich.edu/event/72766 72766-18070596@events.umich.edu Event Begins: Friday, April 10, 2020 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Haoxing Xu

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Workshop / Seminar Tue, 10 Mar 2020 10:51:44 -0400 2020-04-10T12:00:00-04:00 2020-04-10T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials & microscope drawing in yellow on a blue square
A Data Scientist Plays Games (April 16, 2020 12:00pm) https://events.umich.edu/event/74087 74087-18510444@events.umich.edu Event Begins: Thursday, April 16, 2020 12:00pm
Location:
Organized By: Michigan Institute for Data Science

This event will be hosted online via Zoom

A Data Scientist Plays Games:  This is a presentation broken down into two parts.  The first is how to use mathematical techniques to analyze classic card and board games, and the second part is how data science techniques were applied in real life to support games on the Facebook platform.  This presentation is about 1.5 hours, with a target audience probably suited to CS/software engineering.  It’s light-hearted and fun.

Nick Berry, a native of the UK, has lived in Seattle for the last 25 years. He was educated as a rocket scientist and aircraft designer, graduating with a Masters Degree in Aeronautical and Astronautical Engineering.

Upon graduation, he joined a group of friends to form a software company, specializing in electronic mapping and route planning. This company was grown organically, and earned an unprecedented number of awards and accolades, including the British Design Award and The Queen’s Award for Technology, presented by Her Majesty in 1991. In 1994 Nick was recognized by the Sunday Times Magazine as “One of the top 50 entrepreneurs of the decade”. In 1994, after the company had grown to 50 people worldwide, it was sold to Microsoft.

Nick moved to America with the sale and spent 14 years working for Microsoft, the last ten of which were in the Microsoft Casual Game team. During his tenure, he filed a variety of patents for Microsoft, and represented Microsoft at various conferences and speaking engagements.

After leaving Microsoft, he joined RealNetworks to work as the GM of customer analytics for their games division, GameHouse.

After GameHouse, Nick spent five years as a Data Scientist, working for Facebook in their Seattle office.

In addition to his engineering expertise, Nick is passionate about data privacy and holds a CIPP qualification from the International Association of Privacy Professionals. He is an active member of the privacy community and speaks at various events about the legal and ethical aspects of data collection, use, and destruction.

In July 2013, Nick gave a TEDx talk about Passwords and the Internet, and in 2015 was nominated by GeekWire as Geek-of-the-week. In 2019 he was recognized as one of the 50 over 50 in the video games industry.

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Workshop / Seminar Mon, 06 Apr 2020 11:11:49 -0400 2020-04-16T12:00:00-04:00 2020-04-16T13:30:00-04:00 Michigan Institute for Data Science Workshop / Seminar Nick Berry
BME 500: Lonnie Shea (April 16, 2020 4:00pm) https://events.umich.edu/event/70076 70076-17507740@events.umich.edu Event Begins: Thursday, April 16, 2020 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

NOTICE: This event will be hosted via Blue Jeans. The link will be provided below.

Blue Jeans Link: https://umich.bluejeans.com/902489900

The promise of precision health is typically associated with the early detection of disease, and the identification of an individually tailored therapy to extend healthspan while also reducing costs. I will discuss our work on immune engineering, as the immune system is essential to health, and consequently immune dysregulation can lead to disease. Autoimmune disease has been increasing in prevalence for the past few decades, and results from the immune system attacking healthy tissues, such as in Type 1 Diabetes or Multiple Sclerosis. Current treatments typically involve suppressing the entire immune system, despite the immune system attacking specific proteins. Based on the function of the immune system, we have developed nanoparticles that re-program immune responses to specific antigens leading to tolerance to those antigens and leaving the remainder of the immune system intact. The nanoparticles maintain the antigen until internalization by immune cells, with subsequent presentation of the antigen coincident with down-regulation of the co-stimulatory factors and up-regulation of negative co-stimulators. In addition to reprogramming specific immune responses, a need exists for technologies that can detect autoimmune disease initiation prior to substantial destruction of healthy tissues. We have applied tissue engineering principles to generate tissues subcutaneously that function as an immunological niche, which can be accessed easily to avoids risks associated with biopsy of native tissues (e.g., brain,) and thereby report on immune status within tissues. Technologies for detecting disease at the earliest stages combined with reprogramming specific cellular responses represent major opportunities for Precision Health to improve health while containing costs.

Speaker biography:

Lonnie Shea is the Chair of the Department of Biomedical Engineering at the University of Michigan (U-M), which is joint between the College of Engineering and the School of Medicine. He received his PhD in chemical engineering and scientific computing from U-M in 1997, working with Professor Jennifer Linderman. He then served as a postdoctoral fellow with then ChE Professor David Mooney in the Department of Biologic and Materials Science at the U-M Dental School. Shea was recruited to Northwestern University’s Department of Chemical and Biological Engineering and was on the faculty from 1999 to 2014. In 2014, Shea was recruited back to the University of Michigan as chair of the Department of Biomedical Engineering, with his recruitment coinciding with the endowment of the chair position by William and Valerie Hall. He is the Steven A. Goldstein Collegiate Professor of Biomedical Engineering and is an internationally recognized researcher at the interface of regenerative medicine, drug and gene delivery, and immune-engineering, whose focus is on preventing tissue degeneration or promoting tissue regeneration. His projects include islet transplantation for diabetes therapies, nerve regeneration for treating paralysis, autoimmune diseases and allogeneic cell transplantation, cancer diagnostics, and ovarian follicle maturation for treating infertility. He is currently PI or co-PI on 5 NIH grants (4R01’s, 1 R21). The nanoparticle technology for immune tolerance has led to the formation of a company that is leading a series of clinical trials. Shea has published more than 240 manuscripts, and has numerous inventions to his credit. He is the PI for the Coulter Foundation Translational Research grants committee at the University of Michigan. He served as director of Northwestern’s NIH Biotechnology Training Grant. He has received the Clemson Award from the Society for Biomaterials, is a fellow of the American Institute of Medical and Biological Engineering (AIMBE) and the Biomedical Engineering Society (BMES), a member of the editorial boards for multiple journals such as Molecular Therapy, Biotechnology and Bioengineering, and the Journal of Immunology and Regenerative Medicine.

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Workshop / Seminar Thu, 16 Apr 2020 13:10:30 -0400 2020-04-16T16:00:00-04:00 2020-04-16T17:00:00-04:00 Off Campus Location Biomedical Engineering Workshop / Seminar BME Event
UMMA Pop Up: Warren & Flick (April 19, 2020 1:00pm) https://events.umich.edu/event/71631 71631-17846976@events.umich.edu Event Begins: Sunday, April 19, 2020 1:00pm
Location: Museum of Art
Organized By: University of Michigan Museum of Art (UMMA)

Jacob Warren and Grant Flick explore the nuanced textures of a two-person band. Using both original material and  personally arranged standards from many genres, the group finds new depth in the simplicity of duets. The two met at the 2015 Acoustic Music Seminar, a program accepting only sixteen young string players from around the world to participate in a week of intense improvisation, composition and performance training. With Jacob’s classical foundation and Grant’s experience in bluegrass and jazz, their contrasting backgrounds give Warren & Flick a unique and compelling musical narrative. ​ You can find out more on their website, or follow them on Instagram and Facebook.

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Performance Thu, 12 Mar 2020 18:17:11 -0400 2020-04-19T13:00:00-04:00 2020-04-19T14:00:00-04:00 Museum of Art University of Michigan Museum of Art (UMMA) Performance Museum of Art
CANCELED: MIPSE Seminar | Bringing Cosmic Shock Waves Down to Earth (April 22, 2020 3:30pm) https://events.umich.edu/event/72596 72596-18024699@events.umich.edu Event Begins: Wednesday, April 22, 2020 3:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Michigan Institute for Plasma Science and Engineering (MIPSE)

Abstract:
As a fundamental process for converting kinetic to thermal energy, collisionless shocks are ubiquitous throughout the heliosphere and astrophysical systems, from Earth’s magnetosphere to supernova remnants. While these shocks have been studied for decades by spacecraft, telescopes, and numerical simulations, there remain key open questions in shock physics, such as: How do shocks accelerate particles to extremely high energies? or How are particles heated across a shock? Laboratory experiments thus provide a significant opportunity to both complement spacecraft and remote sensing observations with well-controlled and well-diagnosed datasets, and to help benchmark numerical simulations that bridge laboratory and astrophysical systems.
In this talk, I will discuss recent results from experiments and simulations on the formation and evolution of collision-less shocks created through the interaction of a supersonic laser-driven magnetic piston and magnetized ambient plas-ma. Through advanced diagnostics a fast, high-Mach-number shock is observed. Direct probing of particle velocity distributions reveals the coupling between the piston and ambient plasmas that is a key step in forming magnetized collisionless shocks. Particle-in-cell simulations further detail the shock formation process, the role of collisionality, and the dynamics of multi-ion-species ambient plasmas. I will also discuss how this experimental platform complements spacecraft missions and can allow novel investigations of shock heating and particle acceleration.

About the Speaker:
Dr. Schaeffer is an Associate Research Scholar in the Department of Astro-physical Sciences at Princeton University. He received his BA in Physics at Cornell University and his PhD in Physics from UCLA, and did his postdoctoral work at Princeton in high-energy-density laboratory astrophysics. Dr. Schaeffer has extensive experience in experiments involving mag-netized laser plasmas, collisionless shocks, and magnetic reconnection, and a keen interest in bridging laboratory and astronomical observations. He also has expertise in a wide range of di-agnostics, including Thomson scattering, refractive imaging, proton radiography, and x-ray im-aging. He has authored dozens of papers and has presented at numerous conferences around the world.

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Lecture / Discussion Wed, 18 Mar 2020 10:22:24 -0400 2020-04-22T15:30:00-04:00 2020-04-22T16:30:00-04:00 Electrical Engineering and Computer Science Building Michigan Institute for Plasma Science and Engineering (MIPSE) Lecture / Discussion Derek Schaeffer
CANCELED: MIPSE Seminar | Journey to the Sun (April 29, 2020 3:30pm) https://events.umich.edu/event/70795 70795-17957293@events.umich.edu Event Begins: Wednesday, April 29, 2020 3:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Michigan Institute for Plasma Science and Engineering (MIPSE)

Abstract:
NASA Heliophysics research studies a vast system stretching from the Sun to Earth to far beyond the edge of the planets. Studying this system – much of it driven by the Sun’s constant outpouring of solar wind – not only helps us understand fundamental infor-mation about how the universe works, but also helps protect our technology and astronauts in space. NASA seeks knowledge of near-Earth space, because, when extreme, space weather can interfere with our com-munications, satellites and power grids. The study of the Sun and space can also teach us more about how stars contribute to the habitability of planets through-out the universe.
Mapping out this interconnected system requires a holistic study of the Sun’s influence on space, Earth and other planets. NASA has a fleet of spacecraft stra-tegically placed throughout our heliosphere – from Parker Solar Probe at the Sun observing the very start of the solar wind, to satellites around Earth, to the far-thest human-made object, Voyager, which is sending back observations on interstellar space. Each mission is positioned at a critical, well-thought out vantage point to observe and understand the flow of energy and particles throughout the solar system, and all helping us untagle the effects of the star we live with.

About the speaker:
Dr. Nicola Fox is the Heliophysics Division Director in the Science Mission Directorate at NASA Headquarters in Washington, DC. Until August 2018, Dr. Fox worked at the Applied Physics Lab at the Johns Hopkins University where she was the Chief Scientist for Heliophysics and the project scientist for NASA’s Parker Solar Probe. Dr. Fox served as the deputy project scientist for the Van Allen Probes, and the operations scientist for the International Solar Terrestrial Physics program. Fox received her BS in Physics and PhD in Space and Atmospheric Physics from the Imperial College of Science, Technology and Medicine in London. She received an MS in Telematics and Satellite Communications from the University of Surrey.

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Lecture / Discussion Wed, 18 Mar 2020 10:22:50 -0400 2020-04-29T15:30:00-04:00 2020-04-29T17:00:00-04:00 Electrical Engineering and Computer Science Building Michigan Institute for Plasma Science and Engineering (MIPSE) Lecture / Discussion Nicola Fox
VIRTUAL EVENT: Confronting our Climate Grief in the time of COVID-19 (May 7, 2020 2:00pm) https://events.umich.edu/event/68154 68154-17018328@events.umich.edu Event Begins: Thursday, May 7, 2020 2:00pm
Location: Off Campus Location
Organized By: CEW+

This workshop will be held via Zoom (link to follow via email prior to the event). For safety and privacy, you must be registered to receive the link.

In 2017, the American Psychological Association, Climate for Health, and ecoAmerica published, “Mental Health and our Changing Climate: Impacts, Implications, and Guidance.” In October 2018, the U.N. released a report warning that without “unprecedented” political actions, we will likely see catastrophic conditions by 2040. Globally, most communities are already experiencing effects of climate change, and the poorest members of society remain most vulnerable. In this uncertain context, climate grief is real, particularly as the crisis is largely beyond any individual’s ability to control. As a scholar studying climate change, Sampson has sought emerging evidence-based strategies in hopes of coping and building resiliency. In this workshop, together we will: 1) confront our sometimes silent, biggest fears related to climate change, 2) identify ways our community or current professional work may be climate-affected, and 3) create a personal climate resiliency plan that may include household or community action or policy advocacy strategies.

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Livestream / Virtual Thu, 30 Apr 2020 16:22:57 -0400 2020-05-07T14:00:00-04:00 2020-05-07T15:30:00-04:00 Off Campus Location CEW+ Livestream / Virtual Natalie Sampson
Virtual Seminar - "Metabolic engineering strategies: from static to dynamic rewiring of microbial metabolic networks” (June 1, 2020 10:00am) https://events.umich.edu/event/74728 74728-18952538@events.umich.edu Event Begins: Monday, June 1, 2020 10:00am
Location: Off Campus Location
Organized By: Life Sciences Institute (LSI)

Filipa Pereira, Ph.D.
Postdoctoral Fellow
European Molecular Biology Laboratory

Link to attend: https://umich.zoom.us/j/93168574796

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Lecture / Discussion Wed, 27 May 2020 10:54:07 -0400 2020-06-01T10:00:00-04:00 2020-06-01T11:00:00-04:00 Off Campus Location Life Sciences Institute (LSI) Lecture / Discussion
Webinar: Learning Health Systems in the Time of COVID-19 (June 2, 2020 2:00pm) https://events.umich.edu/event/74564 74564-18825099@events.umich.edu Event Begins: Tuesday, June 2, 2020 2:00pm
Location:
Organized By: Department of Learning Health Sciences

This 90-minute webinar is designed to introduce individuals to the overall concept of learning health systems, focusing on core components of learning cycles and infrastructure. It is appropriate for anyone interested in how health systems function, and particularly for individuals working within health systems. We will use examples that span countries and clinical problems, with special emphasis on the SARS-CoV-2 pandemic.

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Lecture / Discussion Mon, 11 May 2020 11:05:21 -0400 2020-06-02T14:00:00-04:00 2020-06-02T15:30:00-04:00 Department of Learning Health Sciences Lecture / Discussion Corona virus and Collaboratory logo
The Job Market Workshop Series (Zoom Meeting) (July 23, 2020 6:30pm) https://events.umich.edu/event/75181 75181-19299040@events.umich.edu Event Begins: Thursday, July 23, 2020 6:30pm
Location:
Organized By: Department of Psychology

The Job Market Series consists of 10 monthly workshops designed for psychology graduate students and postdocs who will soon enter the job market. All graduate students and postdocs are welcome to attend.

The series focuses primarily on the preparation of the application package for academic jobs, including workshops targeted to each section of the application (e.g. cover letters, research statements, etc.).

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Workshop / Seminar Fri, 10 Jul 2020 08:59:24 -0400 2020-07-23T18:30:00-04:00 2020-07-23T20:00:00-04:00 Department of Psychology Workshop / Seminar Job Market Workshop Series
A Simulation Based Comparison of Point-of-Care Testing and Central Laboratory Testing (August 31, 2020 4:30pm) https://events.umich.edu/event/76322 76322-19687515@events.umich.edu Event Begins: Monday, August 31, 2020 4:30pm
Location: Off Campus Location
Organized By: Center for Healthcare Engineering & Patient Safety (CHEPS)

In response to demand for fast and efficient clinical testing, the use of point-of-care testing (POCT) has become increasingly common in the United States. However, studies of POCT implementation have found that adopting POCT may not always be advantageous relative to centralized laboratory testing. We construct a simulation model of patient flow in an outpatient care setting to evaluate tradeoffs involved in POCT implementation across multiple dimensions, comparing measures of patient outcomes in varying clinical scenarios, testing regimes, and patient conditions. We find that POCT can significantly reduce clinical time for patients, as compared to traditional testing regimes, in settings where clinic and central testing areas are far apart. However, as distance from clinic to central testing area decreased, POCT advantage over central laboratory testing also decreased, in terms of time in the clinical system and estimated subsequent productivity loss. For example, testing for pneumonia resulted in an estimated average of 27.80 (central lab) versus 15.50 (POCT) total lost productive hours in a rural scenario, and an average of 14.92 (central lab) versus 15.50 (POCT) hours in a hospital-based scenario. Our results show that POCT can effectively reduce the average time a patient spends in the system for varying condition profiles and clinical scenarios. However, the number of total lost productive hours, a more holistic measure, is greatly affected by testing quality, where POCT often is at a disadvantage. Thus, it is important to consider factors such as clinical setting, target condition, testing costs, and test quality when selecting appropriate testing regime.

Vikrant Vaze is the Stata Family Career Development Associate Professor at Thayer School of Engineering at Dartmouth College. He is interested in developing optimization, game theory, and analytics approaches for improving large-scale complex systems, such as transportation and healthcare. In June 2020, Vikrant was selected as one of 85 engineers who will participate in the National Academy of Engineering’s 2020 US Frontiers of Engineering (NAE) Symposium. He holds two master’s degrees and a Ph.D. from the Massachusetts Institute of Technology in transportation and operations research, and a bachelor’s degree in civil engineering from the Indian Institute of Technology in Mumbai. Before joining academia, he worked as a Research Scientist in Philips Research and as an algorithmic trader on the Wall Street. Joint research work by Vikrant, his students and collaborators has been honored with best paper awards from AGIFORS in 2010, 2017, and 2019, from FAA/Eurocontrol in 2011 and 2017, and most recently with the INFORMS TSL Outstanding Paper Award in Air Transportation. He is the recipient of a number of academic and research honors including the Faculty Early Career Development Program (CAREER) Award from the U.S. National Science Foundation, as well as awards from the U.S. Department of Defense, Federal Aviation Administration, National Institutes of Health, World Wildlife Fund, and several other industry-sponsored awards.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach. For the Zoom link and password and to be added to the weekly e-mail for the series, please RSVP. For additional questions, contact CHEPSseminar@umich.edu. Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Fri, 28 Aug 2020 14:21:43 -0400 2020-08-31T16:30:00-04:00 2020-08-31T17:30:00-04:00 Off Campus Location Center for Healthcare Engineering & Patient Safety (CHEPS) Lecture / Discussion Vikrant Vaze, Ph.D.
BME Seminar Series: Ben Cosgrove (September 3, 2020 4:00pm) https://events.umich.edu/event/75894 75894-19623813@events.umich.edu Event Begins: Thursday, September 3, 2020 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Join us for our virtual seminar series on Thursdays from 4-5pm!
These events will take place on BlueJeans at this link: https://bluejeans.com/628109990

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Workshop / Seminar Thu, 20 Aug 2020 14:01:44 -0400 2020-09-03T16:00:00-04:00 2020-09-03T17:00:00-04:00 Off Campus Location Biomedical Engineering Workshop / Seminar BME
Economic Theory: Cheating with (recursive) models (joint with Ran Spiegler and Yair Weiss) (September 4, 2020 11:00am) https://events.umich.edu/event/81666 81666-20941451@events.umich.edu Event Begins: Friday, September 4, 2020 11:00am
Location: Off Campus Location
Organized By: Department of Economics

Abstract:
To what extent can misspecified subjective models distort correlations? We study an “analyst” who utilizes models that take the form of a recursive system of linear regression equations. The analyst fits each equation to an objective empirical distribution. We characterize the maximal pairwise correlation that the analyst’s model can predict given a generic objective covariance matrix, subject to the constraint that the estimated model does not distort the mean and variance of individual variables. We show that as the number of variables in the model grows, the estimated pairwise correlation can become arbitrarily large, regardless of the objective correlation.

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Workshop / Seminar Wed, 03 Feb 2021 10:59:35 -0500 2020-09-04T11:00:00-04:00 2020-09-04T12:00:00-04:00 Off Campus Location Department of Economics Workshop / Seminar Econ Umich
DCMB / CCMB Weekly Seminar Series (September 9, 2020 4:00pm) https://events.umich.edu/event/76946 76946-19780535@events.umich.edu Event Begins: Wednesday, September 9, 2020 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract: Birth defects that interfere with craniofacial development can result in cognitive, neurosensory, and neuroendocrine defects that create life-long burdens for care. The forebrain, midbrain, hindbrain, five facial prominences, and pituitary gland develop between the first and second month of gestation in humans. Genetic defects that disrupt these processes cause a spectrum of disorders that range from holoprosencephaly (HPE) and septo-optic dysplasia (SOD) to pituitary hormone deficiencies. We screened a large cohort of Argentinean patients with congenital hypopituitarism and related disorders for mutations in known genes and identified novel pathogenic variants and examples of digenic disease. However, the majority of patients did not receive a molecular diagnosis, indicating the high degree of genetic complexity underlying these disorders and the need for additional gene discovery. The majority of known hypopituitarism genes were discovered through basic research in pituitary cell lines and mutant mice. To identify novel regulatory genes for pituitary organogenesis we analyzed differential binding of a key pituitary-specific transcription factor, POU1F1, in cell lines that represent pituitary progenitors and differentiated cells. We discovered that POU1F1 binding is associated with bZIP transcription factors in progenitors and with bHLH factors in differentiated cells. We also applied single cell RNA sequencing technology to analyze gene expression during pituitary organogenesis and discovered novel transcription factors that are candidates for driving cell specification as well as unique, rare cell types that are likely differentiation intermediates. Bioinformatic analyses have played key roles in advancing our knowledge of neuroendocrine birth defects and normal pituitary organogenesis.

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Lecture / Discussion Wed, 09 Sep 2020 08:26:42 -0400 2020-09-09T16:00:00-04:00 2020-09-09T17:00:00-04:00 Off Campus Location DCMB Seminar Series Lecture / Discussion Sally Camper, Ph.D., Margery Shaw Distinguished University Professor of Human Genetics, Professor of Internal Medicine, University of Michigan
BME Seminar Series: Ranu Jung (September 10, 2020 4:00pm) https://events.umich.edu/event/75902 75902-19623820@events.umich.edu Event Begins: Thursday, September 10, 2020 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Join us for our virtual seminar series on Thursdays from 4-5pm!
These events will take place on BlueJeans at this link: https://bluejeans.com/628109990

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Workshop / Seminar Thu, 20 Aug 2020 13:36:24 -0400 2020-09-10T16:00:00-04:00 2020-09-10T17:00:00-04:00 Off Campus Location Biomedical Engineering Workshop / Seminar BME
Economic Theory: Analogy-Based Expectation Equilibrium and Related Concepts: Theory, Applications, and Beyond (September 11, 2020 9:00am) https://events.umich.edu/event/81668 81668-20941453@events.umich.edu Event Begins: Friday, September 11, 2020 9:00am
Location: Off Campus Location
Organized By: Department of Economics

Abstract:
In this survey, I provide a unified definition of analogy-based expectation equilibrium (ABEE) for strategic environments involving multiple stages and private information. I discuss various alternative interpretations of the concept as well as how to use ABEE in practice. I review a variety of applications including two new ones related to speculative trading and personnel economics. I then discuss a number of alternative equilibrium concepts emphasizing the links and differences with ABEE. Finally, I discuss possible next steps in particular related to the endogeneization of analogy partitions.

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Workshop / Seminar Wed, 03 Feb 2021 11:10:19 -0500 2020-09-11T09:00:00-04:00 2020-09-11T10:20:00-04:00 Off Campus Location Department of Economics Workshop / Seminar Econ Umich
Data Science, Time Complexity, and Spacekime Analytics (September 11, 2020 12:00pm) https://events.umich.edu/event/76500 76500-19719162@events.umich.edu Event Begins: Friday, September 11, 2020 12:00pm
Location: Off Campus Location
Organized By: LSA Biophysics

Digital information flows impact all human experiences. The proliferation of large, heterogeneous, and spatio-temporal data requires novel approaches for managing, modeling, analyzing, interpreting, and visualizing complex information. The scientific community is developing, validating, productizing, and supporting novel mathematical techniques, advanced statistical computing algorithms, transdisciplinary tools, and effective artificial intelligence apps.

Spacekime analytics is a new technique for modeling high-dimensional longitudinal data. This approach relies on extending the notions of time, events, particles, and wavefunctions to complex-time (kime), complex-events (kevents), data, and inference-functions. We will illustrate how the kime-magnitude (longitudinal time order) and kime-direction (phase) affect the subsequent predictive analytics and the induced scientific inference. The mathematical foundation of spacekime calculus reveals interesting statistical implications including inferential uncertainty and a Bayesian formulation of spacekime analytics. Complexifying time allows the lifting of all commonly observed processes (e.g., time-series) from the classical 4D Minkowski spacetime to a 5D spacekime manifold (e.g., kime-surfaces), where a number of mathematical problems remain to be solved.

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Livestream / Virtual Tue, 01 Sep 2020 14:53:10 -0400 2020-09-11T12:00:00-04:00 2020-09-11T13:00:00-04:00 Off Campus Location LSA Biophysics Livestream / Virtual Ivo D. Dinov
Economic Theory: Implementation via Transfers with Identical but Unknown Distributions (Joint work with Antonio Penta) (September 15, 2020 1:00pm) https://events.umich.edu/event/81670 81670-20941455@events.umich.edu Event Begins: Tuesday, September 15, 2020 1:00pm
Location: Off Campus Location
Organized By: Department of Economics

Abstract:
We consider mechanism design environments in which agents commonly know that types are identically distributed across agents, but without assuming that the actual distribution is common knowledge, nor that it is known to the designer (common knowledge of identicality). Under these assumptions, we explore problems of partial and full implementation, as well as robustness. First, we characterize the transfers which are incentive compatible under the assumption of common knowledge of identicality, and provide necessary and sufficient conditions for partial implementation. Second, we characterize the conditions under which full implementation is possible via direct mechanisms, as well as the transfer schemes which achieve full implementation whenever it is possible. Finally, we study the robustness properties of the implementing transfers with respect to misspecifications of agents’ preferences and with respect to lower orders beliefs in rationality.

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Workshop / Seminar Wed, 03 Feb 2021 11:17:09 -0500 2020-09-15T13:00:00-04:00 2020-09-15T14:20:00-04:00 Off Campus Location Department of Economics Workshop / Seminar Econ Umich
LHS Collaboratory Seminar Series Virtual Kick-Off: Academic Medical Centers as Learning Health Systems (September 17, 2020 9:00am) https://events.umich.edu/event/75856 75856-19615923@events.umich.edu Event Begins: Thursday, September 17, 2020 9:00am
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Learning Health Systems (LHS) methods are now being implemented in interesting and varying ways by academic health centers and their clinical and translational science institutes across the country.
According to the Agency for Healthcare Research and Quality (AHRQ), the following are key attributes of Learning Health
Systems:

• Having leaders who are committed to a culture of continuous learning and improvement
• Systematically gathering and applying evidence in real-time to guide care
• Employing IT methods to share new evidence with clinicians to improve decision-making
• Promoting the inclusion of patients as vital members of the learning team
• Capturing and analyzing data and care experiences to improve care
• Continually assessing outcomes, refining processes and training to create a feedback cycle for learning and improvement

The LHS Collaboratory's fall seminar series virtual kick-off event will showcase the LHS experiences of three research-intensive academic centers that have been promoting LHS methods. We will be joined by distinguished senior colleagues from Duke,Vanderbilt, and Washington University, who will describe and discuss their institutions' work in this area. They will discuss strategies employed, investments made, challenges encountered, and successes achieved.

Panelists:
Kevin B. Johnson, MD, MS, FAAP, FACMI, Vanderbilt University
Christopher J. Lindsell, PhD, Vanderbilt University
Philip Payne, PhD, FACMI, Washington University
Michael Pencina, PhD, Duke University
Eric G. Poon, MD, MPH, Duke University

Discussant:
Carol R. Bradford, MD, MS, Executive Vice Dean for Academic Affairs, University of Michigan Medical School, Chief Academic Officer, Michigan Medicine, Professor of Otolaryngology-Head and Neck Surgery

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Lecture / Discussion Thu, 20 Aug 2020 09:45:31 -0400 2020-09-17T09:00:00-04:00 2020-09-17T11:00:00-04:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion LHS Collaboratory Logo-blocks
BME Seminar Series: Orlando Hoilett (September 17, 2020 4:00pm) https://events.umich.edu/event/75903 75903-19623821@events.umich.edu Event Begins: Thursday, September 17, 2020 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Join us for our virtual seminar series on Thursdays from 4-5pm!
These events will take place on BlueJeans at this link: https://bluejeans.com/628109990

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Workshop / Seminar Thu, 20 Aug 2020 13:51:27 -0400 2020-09-17T16:00:00-04:00 2020-09-17T17:00:00-04:00 Off Campus Location Biomedical Engineering Workshop / Seminar BME
Biophysics Virtual Seminar Series (September 18, 2020 12:00pm) https://events.umich.edu/event/76959 76959-19780559@events.umich.edu Event Begins: Friday, September 18, 2020 12:00pm
Location: Off Campus Location
Organized By: LSA Biophysics

*Please see below for the link to join the Zoom livestream*

The Biophysics Virtual Seminar Series Presents:

Zhenyu Tan - Biophysics Ph.D. Candidate (Cianfrocco Group)

The mitochondrial cargo adaptor TRAK1 has overlapping binding sites for kinesin-1 and dynein

Abstract: Positioning of axonal mitochondria into target locations is critical for the physiology of neurons as they supply energy and calcium buffering capacity. The outer mitochondrial membrane protein Miro cooperates with TRAK1 and TRAK2 to scaffold kinesin and dynein, driving anterograde and retrograde mitochondrial transport. To understand how TRAK1 regulates both kinesin and dynein, we utilized biochemical reconstitution to define the minimal region of TRAK1 sufficient for promoting motor activation. We characterized that TRAK1 has overlapping binding sites for kinesin-1 and dynein that is capable of activating both motors *in vitro*.

Thomas Paul - Postdoctoral Researcher (Brooks Group)

pH Dependent Dissociation of Folate from Folic Acid Receptors

Abstract: The pH dependent binding and release of folate from folic acid receptors (FRs) is not well understood. Therefore, we have studied pKa shifts for two isoforms of FRs (FOLR1 and FOLR2) in their apo and holo forms using explicit solvent constant pH molecular dynamics (CPHMD^MSλD). Our key findings highlight amino acid residues that have upward pKa shifts that contribute significantly to destabilizing the FRs:folate complex at pH values consistent with an endosomal environment which allows us to propose a potential mechanism of release.

Zoom passcode: 677763

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Livestream / Virtual Wed, 16 Sep 2020 10:45:33 -0400 2020-09-18T12:00:00-04:00 2020-09-18T13:00:00-04:00 Off Campus Location LSA Biophysics Livestream / Virtual Zhenyu Tan, PhD Candidate and Thomas Paul, Researcher
DCMB / CCMB Weekly Virtual Seminar featuring Gioele La Manno, Ph.D. (EPFL Life Sciences Early Independent Research Scholar (ELISIR) (September 18, 2020 12:00pm) https://events.umich.edu/event/77057 77057-19836073@events.umich.edu Event Begins: Friday, September 18, 2020 12:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

I will present our comprehensive single-cell transcriptome atlas of mouse brain development spanning from gastrulation to birth. In this atlasing effort, we identified almost a thousand distinct cellular states, including the initial emergence of the neuroepithelium, different glioblasts, and a rich set of region-specific secondary organizers that we localize spatially. In this context, I will provide an example of how the spatially-resolved transcriptomic data can be particularly useful to interpret the complexity of such complex atlases.

Continuing in this direction, I will show the approach that we recently proposed as a general way to spatially resolve different types of next-generation sequencing data. We designed an imaging-free framework to localize high throughput readouts within a tissue by combining compressive sampling and image reconstruction. Our first implementation of this framework transformed a low-input RNA sequencing protocol into an imaging-free spatial transcriptomics technique (STRP-seq).

Finally, I will showcase the technique with the profiling of the brain of the Australian bearded dragon Pogona vitticeps. With this analysis, we revealed the molecular anatomy of the telencephalon of this lizard and provided evidence for a marked regionalization of the reptilian pallium and subpallium.

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Lecture / Discussion Wed, 16 Sep 2020 11:27:53 -0400 2020-09-18T12:00:00-04:00 2020-09-18T13:00:00-04:00 Off Campus Location DCMB Seminar Series Lecture / Discussion Gioele La Manno, Ph.D. (EPFL Life Sciences Early Independent Research Scholar (ELISIR) École polytechnique fédérale de Lausanne ‐ EPFL Swiss Federal Institute of Technology Lausanne)
Economic Theory: Lemonade from Lemons: Information Design and Adverse Selection (Joint work with Weijie Zhong) (September 18, 2020 2:30pm) https://events.umich.edu/event/81671 81671-20941456@events.umich.edu Event Begins: Friday, September 18, 2020 2:30pm
Location: Off Campus Location
Organized By: Department of Economics

Details to come.

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Workshop / Seminar Wed, 03 Feb 2021 11:21:38 -0500 2020-09-18T14:30:00-04:00 2020-09-18T15:50:00-04:00 Off Campus Location Department of Economics Workshop / Seminar Econ Umich
Cognitive Science Seminar Series (September 21, 2020 2:30pm) https://events.umich.edu/event/77448 77448-19854032@events.umich.edu Event Begins: Monday, September 21, 2020 2:30pm
Location: Off Campus Location
Organized By: Weinberg Institute for Cognitive Science

Join the Cognitive Science Seminar Series for its first meeting of the Fall 2020 semester.

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Social / Informal Gathering Fri, 18 Sep 2020 14:57:11 -0400 2020-09-21T14:30:00-04:00 2020-09-21T15:30:00-04:00 Off Campus Location Weinberg Institute for Cognitive Science Social / Informal Gathering
CHEPS Alums and their Experience Fighting COVID-19 (September 21, 2020 4:30pm) https://events.umich.edu/event/77491 77491-19875789@events.umich.edu Event Begins: Monday, September 21, 2020 4:30pm
Location:
Organized By: Center for Healthcare Engineering & Patient Safety (CHEPS)

As the COVID-19 pandemic became widespread, health systems had to adjust and problem-solve rapidly. On this panel, alumni of the Center for Healthcare Engineering and Patient Safety will discuss how they and their institutions responded to COVID-19 and worked to address new operational challenges while keeping patients and healthcare workers safe.

Joe East is Director of Patient Flow at Maine Medical Center where he is using systems engineering to improve patient care. He holds an MHSA in Health Care Administration/Management and an MSE in Industrial and Operations Engineering with a concentration in Healthcare Engineering and Patient Safety from the University of Michigan. In his time at Maine Medical he has improved discharge and patient placement processes, worked on nurse staffing models, and created actionable dashboards and reports.

Pamela Martinez is a Process Engineer and Project Manager for the UCHealth CARE Innovation Center. She holds an MSE in Industrial and Operations Engineering from the University of Michigan with a concentration in Healthcare Engineering and Patient Safety. Pam’s focus is to improve the efficiency, safety, and quality of healthcare delivery through Industrial and Systems Engineering principles.

Bill Zhang is Director of Hospital and Procedural Services at Kaiser Permanente. He holds an MPH in Health Care Administration/Management and an MSE in Industrial and Operations Engineering with a concentration in Healthcare Engineering and Patient Safety from the University of Michigan. He works to utilize technology & engineering tools to transform healthcare and make positive impact on people’s lives by developing outcome-oriented, cost-effective and efficient healthcare solutions.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach. For the Zoom link and password and to be added to the weekly e-mail for the series, please RSVP. For additional questions, contact CHEPSseminar@umich.edu. Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Workshop / Seminar Mon, 21 Sep 2020 11:37:18 -0400 2020-09-21T16:30:00-04:00 2020-09-21T17:30:00-04:00 Center for Healthcare Engineering & Patient Safety (CHEPS) Workshop / Seminar photos of speakers & seminar information
Older Adults, Tech Use, and Social Well-Being during COVID-19 and Beyond (September 21, 2020 4:30pm) https://events.umich.edu/event/77493 77493-19875791@events.umich.edu Event Begins: Monday, September 21, 2020 4:30pm
Location: Off Campus Location
Organized By: Center for Healthcare Engineering & Patient Safety (CHEPS)

Nearly one in three older adults in the U.S. experienced some form of loneliness in 2019. The COVID-19 pandemic significantly restricted older adults’ (ages 65+) in-person social interactions, likely increasing loneliness among this demographic. Due to these restrictions, older adults have started to change their relationships with technology to communicate with family and friends at a distance using smartphones and computers. However, these technologies may not be accessible for all older adults. Voice-based technologies such as Amazon Alexa and Google Assistant can be more accessible to those with motor challenges or vision loss/blindness, yet have not been studied in-depth for how they can support older adult’s well-being. In this talk, I will discuss (1) a recent interview study with older adults COVID-19 technology use and (2) a recent analysis of more than 50,000 queries older adults made to the Amazon Alexa for social well-being. Early findings point to positive and negative aspects of using technology for well-being and aging.

Robin Brewer is an Assistant Professor in the School of Information at the University of Michigan. She also holds a courtesy appointment in Computer Science and Engineering. Dr. Brewer’s research in Human-Computer Interaction (HCI) asks (1) how experiences with technology can be more accessible to digitally constrained communities and (2) how these communities use technology for social well-being. Much of her work focuses on older adults and people with vision impairments. Dr. Brewer holds a Ph.D. in Technology and Social Behavior from Northwestern University, M.S. in Human-Centered Computing from University of Maryland - Baltimore County, and B.S. in Computer Science from the University of Maryland - College Park.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach. For the Zoom link and password and to be added to the weekly e-mail for the series, please RSVP. For additional questions, contact CHEPSseminar@umich.edu. Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Mon, 21 Sep 2020 11:54:41 -0400 2020-09-21T16:30:00-04:00 2020-09-21T17:30:00-04:00 Off Campus Location Center for Healthcare Engineering & Patient Safety (CHEPS) Lecture / Discussion photo of speaker with event information
Economic Theory: Organized Information Transmission (Joint work with Ina Taneva) (September 22, 2020 1:00pm) https://events.umich.edu/event/81672 81672-20941457@events.umich.edu Event Begins: Tuesday, September 22, 2020 1:00pm
Location: Off Campus Location
Organized By: Department of Economics

Abstract:
In reality, how information is transmitted to its recipients is as important as its content. In this paper, we introduce families of (indirect) information structures — meeting schemes and delegated hierarchies — that capture the horizontal and vertical dimensions of real-world transmission. We characterize the outcomes that they implement in general (finite) games and show that they are optimal in binary-action environments with strategic complementarities. Our main application illustrates how the optimal meeting scheme and the optimal delegated hierarchy change with the objective function in a classical regime-change game.

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Workshop / Seminar Wed, 03 Feb 2021 11:23:46 -0500 2020-09-22T13:00:00-04:00 2020-09-22T14:20:00-04:00 Off Campus Location Department of Economics Workshop / Seminar Econ Umich
DCMB / CCMB Weekly Virtual Seminar (September 23, 2020 4:00pm) https://events.umich.edu/event/77143 77143-19798542@events.umich.edu Event Begins: Wednesday, September 23, 2020 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Talk title: Decision Support System Applications in Dentistry

Dr. Lucia Cevidanes is the Thomas and Doris Graber Professor of Dentistry and Associate Professor at the Department of Orthodontics at the University of Michigan, and a Diplomate of the American Board of Orthodontics. She is a practicing clinician who has published over 150 manuscripts on 3D imaging for which she has received research grants from the American Association of Orthodontics Foundation and the National Institute of Dental and Craniofacial Research. Her work has been recognized by the American Association of Orthodontists Thomas M. Graber Award, the B F Dewel Award, Milo Hellman Award, and the Wuehrmann award from the American Academy of Oral and Maxillofacial Radiology. Her interests include Artificial Intelligence and 3D Imaging to solve difficult clinical problems in dentistry, studying current and new treatment approaches and technical procedures, and understanding treatment outcomes for craniofacial anomalies and dentofacial deformities.

Zoom Link: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Lecture / Discussion Fri, 11 Sep 2020 15:27:53 -0400 2020-09-23T16:00:00-04:00 2020-09-23T17:00:00-04:00 Off Campus Location DCMB Seminar Series Lecture / Discussion Dr. Lucia Cevidanes is the Thomas and Doris Graber Professor of Dentistry and Associate Professor at the Department of Orthodontics at the University of Michigan
Postdoc Appreciation Seminars at the School of Dentistry (September 24, 2020 12:00pm) https://events.umich.edu/event/77254 77254-19828126@events.umich.edu Event Begins: Thursday, September 24, 2020 12:00pm
Location: Off Campus Location
Organized By: Office of Research School of Dentistry

Jessica A. Ferreira – Bottino Lab
Jingwen Yang – Mishina Lab
Veronica Mendoza-Reinoso – McCauley/Roca Lab

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Lecture / Discussion Tue, 15 Sep 2020 09:49:10 -0400 2020-09-24T12:00:00-04:00 2020-09-24T13:00:00-04:00 Off Campus Location Office of Research School of Dentistry Lecture / Discussion flyer
BME Seminar Series: Jane Grande-Allen (September 24, 2020 4:00pm) https://events.umich.edu/event/75904 75904-19623822@events.umich.edu Event Begins: Thursday, September 24, 2020 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Join us for our virtual seminar series on Thursdays from 4-5pm!
These events will take place on BlueJeans at this link: https://bluejeans.com/628109990

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Workshop / Seminar Thu, 20 Aug 2020 13:53:40 -0400 2020-09-24T16:00:00-04:00 2020-09-24T17:00:00-04:00 Off Campus Location Biomedical Engineering Workshop / Seminar BME
MCDB Virtual Seminar: Regulation of neural stem cell maintenance and differentiation (September 25, 2020 12:00pm) https://events.umich.edu/event/77362 77362-19846066@events.umich.edu Event Begins: Friday, September 25, 2020 12:00pm
Location: Off Campus Location
Organized By: Department of Molecular, Cellular, and Developmental Biology

Virtual seminar: The Lee lab is focused on understanding the mechanisms that regulate the decision to self-renew or differentiate in Drosophila neuroblasts (i.e., neural stem cells). Their research has combined elegant fly genetics, imaging and molecular genetics to gain a detailed understanding of the transcriptional and post-transcriptional hierarchies controlling the asymmetric division of neuroblasts in the larval brain.

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Workshop / Seminar Mon, 21 Sep 2020 11:11:30 -0400 2020-09-25T12:00:00-04:00 2020-09-25T14:00:00-04:00 Off Campus Location Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Diagram showing mechanisms that poise the master regulator of differentiation for rapid activation
Economic Theory: Dynamic Contracting with Flexible Monitoring (Joint work with Liang Dai and Yenan Wang) (September 25, 2020 2:30pm) https://events.umich.edu/event/81674 81674-20941458@events.umich.edu Event Begins: Friday, September 25, 2020 2:30pm
Location: Off Campus Location
Organized By: Department of Economics

Abstract:
We study a dynamic contracting problem in which the principal can allocate his limited capacity between seeking evidence that confirms or that contradicts the agent's effort, as the basis for reward or punishment. Such flexibility calls for jointly designed monitoring and compensation schemes practically relevant but novel in the literature. When the agent's continuation value is low, the principal seeks only confirmatory evidence, but when the agent's continuation value exceeds a threshold, the principal switches to seeking mainly contradictory evidence. Moreover, the agent's effort can be perpetuated if and only if both synergy and flexibility in monitoring are sufficiently large.

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Workshop / Seminar Wed, 03 Feb 2021 11:27:08 -0500 2020-09-25T14:30:00-04:00 2020-09-25T15:50:00-04:00 Off Campus Location Department of Economics Workshop / Seminar Econ Umich
Cognitive Science Seminar Series (September 28, 2020 2:30pm) https://events.umich.edu/event/77453 77453-19854035@events.umich.edu Event Begins: Monday, September 28, 2020 2:30pm
Location: Off Campus Location
Organized By: Weinberg Institute for Cognitive Science

Linguistics graduate student Rachel Weissler will give a talk titled "Cognitive behavioral evidence of linguistic expectation based on both speaker identity and language variety in American Englishes."

ABSTRACT
In order to understand the intersection of linguistics, neurological processing, and race, I engage with language variation and social cognition to better understand how we as listeners interact with people who speak varying language varieties in the U.S., particularly African American English (AAE), through a three study dissertation using mixed methodologies. Bountiful neurolinguistics evidence shows that people invoke prediction during sentence processing through ERPs (Kutas et al 2014), and that these predictions are conditioned by the identity of the speaker, as early as 200-300 milliseconds after the beginning of a word(van Berkum et al 2008). However, ideologies about standard language in the U.S. often posit Standardized American English (SdAE) as a morally superior variety (Hill 2008). This hierarchical treatment of language varieties leads to negative perceptions of minoritized language varieties, such as AAE, which in turn makes them stigmatized, and ultimately perpetuates minoritized language discrimination. Thus, the first two studies ask, does positing SdAE as superior lead us to treat all minoritized language varieties equally, or do people have language variety-specific expectations? We test this using two EEG experiments. The final study (in progress) examines how the influence of varied linguistic knowledge modulates perception and online processing of AAE, as indexed by responses elicited from a virtual eye-tracking study. This final study seeks to understand how listeners of varied knowledges process linguistic variation in AAE & SdAE, and also brings together eye-tracking and emotion, expanding upon previous research which shows that various cultural groups are differently sensitive to emotional differences expressed in language, and arguably, through prosody (Weissler & Boland 2019). With this dissertation, I want to enhance the linguistics field by tapping into the find-grained knowledge correlates that listeners bring with them when processing language, specifically AAE. I also want to make the connection between language knowledge and racialization based on that language knowledge.This work has implications not only for intracultural perception, but more broadly, for understanding the functionality of the human language faculty in general. Ultimately, perceptions of stigmatized languages and language varieties leads to language discrimination, which affects the way speakers, people, are treated in their day to day lives. Through a multi-method neurolinguistic and sociolinguistic approach, we can better understand how the human language faculty is capable of recognizing and processing American English language varieties.

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Livestream / Virtual Fri, 25 Sep 2020 14:08:32 -0400 2020-09-28T14:30:00-04:00 2020-09-28T15:30:00-04:00 Off Campus Location Weinberg Institute for Cognitive Science Livestream / Virtual Rachel Weissler
Economic Theory: Signaling with Private Monitoring (Joint work with Aaron Kolb) (September 29, 2020 1:00pm) https://events.umich.edu/event/81675 81675-20941459@events.umich.edu Event Begins: Tuesday, September 29, 2020 1:00pm
Location: Off Campus Location
Organized By: Department of Economics

Abstract
We study dynamic signaling when the informed party does not observe the signals generated by her actions. A long-run player signals her type continuously over time to a myopic second player who privately monitors her behavior; in turn, the myopic player transmits his private inferences back through an imperfect public signal of his actions. Preferences are linear-quadratic and the information structure is Gaussian. We construct linear Markov equilibria using belief states up to the long-run player’s second-order belief. Because of the private monitoring, this state is an explicit function of the long-run player’s past play. A novel separation effect then emerges through this second-order belief channel, altering the traditional signaling that arises when beliefs are public. Applications to models of leadership, reputation, and trading are examined.

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Workshop / Seminar Wed, 03 Feb 2021 11:30:02 -0500 2020-09-29T13:00:00-04:00 2020-09-29T14:20:00-04:00 Off Campus Location Department of Economics Workshop / Seminar Econ Umich
MIPSE Seminar | Relativistic Nanophotonics: Creating Extreme Plasma Conditions and Fields with Ultrafast Lasers (September 30, 2020 3:30pm) https://events.umich.edu/event/76451 76451-19717148@events.umich.edu Event Begins: Wednesday, September 30, 2020 3:30pm
Location: Off Campus Location
Organized By: Michigan Institute for Plasma Science and Engineering (MIPSE)

The seminar is free and open to the public.
To request the Zoom link, please send an email to:
mipse-central@umich.edu

Abstract:
Ultra-high-energy-density (UHED) matter (>108 J cm-3, >109 bar) is encountered in the center of stars but is difficult to create in the lab. We show that irradiation of high aspect-ratio aligned nanowire arrays with ultra-high contrast Joule-level fs laser pulses provides nearly complete absorption and enhanced light penetration into near-solid density targets, and allows volumetric heating into the UHED regime. Using ALEPH (Advance Laser for Extreme Photonics), a PW laser at CSU, we demonstrate that fs laser pulses of relativistic intensity volumetrically heat near-solid density plasmas to multi-keV temperatures, with pressures surpassed in the lab only in the hotspot of fusion plasmas. The physics of relativistic laser pulse interactions with nanostructures and promising applications will be reviewed. Electron densities >100x that of the critical density are achieved. Extraordinarily high degrees of ionization (e.g., Au+72) occurs at solid densities using laser pulses of <10 J, producing return currents through the nanowires that create giga-Gauss magnetic fields. The large electron density and plasma volume produce 20% energy conversion into ps x-ray pulses. Acceleration of deuterons from nanowire arrays to multi-MeV resulted in quasi-monochromatic fusion neutron production 500x that of irradiating flat sold targets. 3-D PIC simulations of relativistic laser pulse interactions with nanostructures will be discussed.

About the Speaker:
Dr. Jorge Rocca is a University Distinguished Professor in the Electrical and Computer Engineering and Physics Departments at Colorado State University. His research interests are in the physics and development of compact X-ray lasers and their applications; the development of high power lasers, and the study of high power laser interactions with matter. His group is known for the development of the first bright table-top soft X-ray lasers, and their applications to nanotechnology and the diagnostics of dense plasmas. His group has developed a multi-Hz PW-class laser, and kW-level average power, high pulse energy picosecond solid state lasers. Prof. Rocca has 270 peer review journal papers. He received the Arthur L. Schawlow Prize in Laser Science from the APS, and the Willis E. Lamb Award for Laser Science and Quantum Optics. He is Fellow of APS, OSA, and IEEE. He received an IEEE LEOS Distinguished Lecturer Award. Early in his career, he was a National Science Foundation Presidential Young Investigator.

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Livestream / Virtual Tue, 01 Sep 2020 10:31:50 -0400 2020-09-30T15:30:00-04:00 2020-09-30T16:30:00-04:00 Off Campus Location Michigan Institute for Plasma Science and Engineering (MIPSE) Livestream / Virtual Prof. Jorge Rocca
DCMB / CCMB Weekly Virtual Seminar - Xiaotian Zhang, Ph.D. (September 30, 2020 4:00pm) https://events.umich.edu/event/77549 77549-19883820@events.umich.edu Event Begins: Wednesday, September 30, 2020 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract: The human genome is organized into small compartments to allow for the proper gene expression regulation in the physiological process. With the advance of next-generation sequencing and imaging technologies, we can now investigate how the genome is folded into 3D space and how the 3D genomic organization regulates gene expression in development and disease. Currently, most of the studies are focusing on CTCF and cohesion complex which partner together to facilitate the formation of topological associated domains (TAD). The presenter will mainly discuss his recently published work on the DNA methylation -3D genomics cross-talk. Unpublished work on the 3D genomics in AML will be discussed as well.

Short bio: Xiaotian Zhang obtained his Ph.D. at Baylor College of Medicine with Dr. Margaret Goodell on the role of DNA methylation synergy in leukemia development. He was previously the Van Andel special postdoc fellow in Gerd Pfeifer lab working on the 3D genomics in normal hematopoietic stem cell and leukemia. He is now a Research track faculty (Research Investigator) in Pathology Department under Tomek Cierpicki working on the HOXA regulation in leukemia development. Xiaotian's research focuses on the epigenetic regulation of key pathogenic genes in leukemia, particularly on high order chromatin structure in disease. He published on Nature Genetics, Molecular Cell and Blood as the first author and corresponding authors.

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Lecture / Discussion Tue, 22 Sep 2020 09:31:31 -0400 2020-09-30T16:00:00-04:00 2020-09-30T17:00:00-04:00 Off Campus Location DCMB Seminar Series Lecture / Discussion Xiaotian Zhang, Ph.D., Research Investigator in the Department of Pathology at the University of Michigan
How shall we drug the MAPK pathway in Head and Neck Cancer? From exceptional responses to Immunogenomics (October 1, 2020 12:00pm) https://events.umich.edu/event/77492 77492-19875790@events.umich.edu Event Begins: Thursday, October 1, 2020 12:00pm
Location: Off Campus Location
Organized By: Office of Research School of Dentistry

Vivian Wai Yan Lui, PhD
Associate Professor and Deputy Chief
(Cancer Biology and Experimental Therapeutics)
Pharmacogenomics Working Group,
National Society of Genetic Counselors (NSGC), USA
Joint CUHK-NTEC Clinical Research Ethics Committee, CUHK
SBS College Coordinator, United College, CUHK
School of Biomedical Sciences
Faculty of Medicine
The Chinese University of Hong Kong

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Presentation Mon, 21 Sep 2020 11:49:50 -0400 2020-10-01T12:00:00-04:00 2020-10-01T13:00:00-04:00 Off Campus Location Office of Research School of Dentistry Presentation seminar flyer
BME Seminar Series: Gautam Parthasarathy (October 1, 2020 4:00pm) https://events.umich.edu/event/75905 75905-19623823@events.umich.edu Event Begins: Thursday, October 1, 2020 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Join us for our virtual seminar series on Thursdays from 4-5pm!
These events will take place on BlueJeans at this link: https://bluejeans.com/628109990

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Workshop / Seminar Thu, 20 Aug 2020 13:56:48 -0400 2020-10-01T16:00:00-04:00 2020-10-01T17:00:00-04:00 Off Campus Location Biomedical Engineering Workshop / Seminar BME
Statistics Department Seminar Series: Laura Kubatko, Professor, Departments of Statistics and Evolution, Ecology, and Organismal Biology, The Ohio State University (October 2, 2020 10:00am) https://events.umich.edu/event/77451 77451-19854034@events.umich.edu Event Begins: Friday, October 2, 2020 10:00am
Location: Off Campus Location
Organized By: Department of Statistics

Abstract: The advent of rapid and inexpensive DNA sequencing technologies has necessitated the development of computationally efficient methods for analyzing sequence data for many genes simultaneously in an evolutionary framework. The coalescent process is the most commonly used model for linking the underlying genealogies of individual genes with the global species-level phylogenetic tree, but inference under the coalescent model is computationally daunting in the typical inference frameworks (e.g., the likelihood and Bayesian frameworks) due to the dimensionality of the space of both gene trees and species trees. By viewing the data arising under the phylogenetic coalescent model as a collection of site patterns, the algebraic structure associated with the probability distribution on the site patterns can be used to develop computationally efficient methods for inference via phylogenetic invariants. In this talk, I will describe how identifiability results for four-taxon species trees based on site pattern probabilities can be used to build a quartet-based inference algorithm for trees of arbitrary size. I will also show how a composite likelihood approach based on quartets can be developed to obtain estimators of the branch lengths within the tree that are consistent and asymptotically normal. I will demonstrate the performance of the methods by applying them to both simulated and empirical data. Because these methods are derived in a fully model-based framework (i.e., the coalescent process is used to model the relationship between gene trees and the species tree, and standard nucleotide substitution models (GTR+I+G and all submodels) are used for sequence-level evolution), they are promising approaches for computationally efficient, model-based inference for the large-scale sequence data available today.

This seminar will be livestreamed via Zoom https://umich.zoom.us/j/94350208889
There will be a virtual reception to follow.

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Workshop / Seminar Fri, 18 Sep 2020 15:26:22 -0400 2020-10-02T10:00:00-04:00 2020-10-02T11:00:00-04:00 Off Campus Location Department of Statistics Workshop / Seminar Laura Kubatko
Biophysics Virtual Seminar Series (October 2, 2020 12:00pm) https://events.umich.edu/event/77871 77871-19939555@events.umich.edu Event Begins: Friday, October 2, 2020 12:00pm
Location: Off Campus Location
Organized By: LSA Biophysics

*Please see below for link to join the Zoom event. Passcode: Biophysics*

The Biophysics Virtual Seminar Series Presents:

Nirupama Sumangala - Biophysics Ph.D. Candidate (Ramamoorthy Group)

"Lipid Membrane Plays an Important Role for Facilitating Electron Transfer in Cytochrome P450"

Abstract: Cytochrome P450s (CYP450s) are a ubiquitous superfamily of enzymes that play a vital role in the metabolism of many exogenous and endogenous substrates including over 70% of the drugs on the market. For the catalytic reaction, CYP450 requires two electrons to be subsequently delivered, with the first one coming from cytochrome P450 reductase (CPR) and the second one from either CPR or cytochrome b5 (cytb5). We are interested in understanding the role of membrane in mediating the electron transfer from redox partners to CYP450. Our findings reveal that the lipid membrane is crucial to mediate a productive CYP450-CPR complex for electron transfer. Our data emphasizes the importance of studying the structure, dynamics and kinetics of CYP450 metabolon in a biologically relevant membrane mimetic system.

Keanu Guardiola Flores - Biophysics Ph.D. Candidate (Wood Group)

"Drug Effects on *Enterococcus Faecalis* Biofilms: Growth, Topology, and Population Dynamics"

Abstract: The emergence of antibiotic resistance poses a growing threat to public health and increasingly limits our ability to treat and control infections. Recently, researchers have shifted their focus to length scales where ecological and evolutionary dynamics of bacterial communities highlight new approaches for slowing resistance with currently available drugs. By combining confocal microscopy with simple mathematical models I will show how antibiotics shape the composition of biofilms as well as their spatial architecture at the single-cell level. Our results suggest that in spatially structured populations, which may more accurately reflect natural bacterial communities, the selection of resistance is not a simple result of homogenous selections but depends critically on the spatial arrangement of cells.

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Livestream / Virtual Tue, 29 Sep 2020 08:47:28 -0400 2020-10-02T12:00:00-04:00 2020-10-02T13:00:00-04:00 Off Campus Location LSA Biophysics Livestream / Virtual
MCDB Virtual Seminar: Neural basis of host seeking in skin-penetrating nematodes (October 2, 2020 12:00pm) https://events.umich.edu/event/77385 77385-19846072@events.umich.edu Event Begins: Friday, October 2, 2020 12:00pm
Location: Off Campus Location
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Monica Dus

Seminar: 12 pm - 1 pm
Q&A: 1:15 pm-2:00 pm

https://umich.zoom.us/j/92994136746

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Workshop / Seminar Fri, 25 Sep 2020 14:19:06 -0400 2020-10-02T12:00:00-04:00 2020-10-02T14:00:00-04:00 Off Campus Location Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Elissa Hallem
Economics at Work (October 2, 2020 1:00pm) https://events.umich.edu/event/78076 78076-19957575@events.umich.edu Event Begins: Friday, October 2, 2020 1:00pm
Location: Off Campus Location
Organized By: Department of Economics

Economics@Work is intended for any student who is interested in learning about a variety of career opportunities for economics majors. Early students of economics may use this class to explore whether an economics major best suits their interests and goals. Advanced students in economics will benefit from the information and networking opportunities.

To join the seminar, please register from the following link.
https://forms.gle/k5yhSQDcPPmUupVXA

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Workshop / Seminar Thu, 01 Oct 2020 17:14:11 -0400 2020-10-02T13:00:00-04:00 2020-10-02T14:30:00-04:00 Off Campus Location Department of Economics Workshop / Seminar Econ Umich
Economic Theory: Robust Monopoly Regulation (Joint work with Eran Shmaya) (October 2, 2020 2:30pm) https://events.umich.edu/event/81676 81676-20941460@events.umich.edu Event Begins: Friday, October 2, 2020 2:30pm
Location: Off Campus Location
Organized By: Department of Economics

Abstract
We study the regulation of a monopolistic firm using a non-Bayesian approach. We derive the policy that minimizes the regulator’s worst-case regret, where regret is the difference between the regulator’s complete-information payoff and his realized payoff. When the regulator’s payoff is consumers’ surplus, he imposes a price cap. When his payoff is the total surplus of both consumers and the firm, he offers a capped piece-rate subsidy. For intermediate cases, the regulator uses both a price cap and a capped piece-rate subsidy. The optimal policy balances three goals: giving more surplus to consumers, mitigating underproduction, and mitigating overproduction.

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Workshop / Seminar Wed, 03 Feb 2021 11:32:35 -0500 2020-10-02T14:30:00-04:00 2020-10-02T15:50:00-04:00 Off Campus Location Department of Economics Workshop / Seminar Econ Umich
Cognitive Science Seminar Series (October 5, 2020 2:30pm) https://events.umich.edu/event/77842 77842-19933640@events.umich.edu Event Begins: Monday, October 5, 2020 2:30pm
Location: Off Campus Location
Organized By: Weinberg Institute for Cognitive Science

Research fellow Elisa Felsche (U-M Psychology) will give a talk on "The origins of inference: A hierarchical Bayesian modelling approach to imitation and abstraction in children and primates."

NOTE: If you would like to attend this meeting, please send an email to cogsi-seminar@umich.edu to receive the passcode.

ABSTRACT

Humans have an immense behavioural and cognitive repertoire that has been shaped by cumulative cultural evolution. In my PhD project I investigated two cognitive abilities that crucially enlarge the efficiency of skill and knowledge acquisition: 1) the capability for abstraction that enables powerful generalization of information to make wide ranging predictions in new situations and 2) the ability to imitate others which allows the quick and low-risk adoption of new behavioural strategies. Despite decades of accumulating data in both domains, it is still debated to what extent other species share these abilities and how they develop in humans. Solving these persisting disagreements requires an alteration of how data are generated and analysed.
In my dissertation project, I introduced the approach of hierarchical Bayesian modelling to the field of comparative psychology to investigate abstract rule formation and action copying in capuchin monkeys, chimpanzees (only abstract rule formation) and children. In the first two studies participants had to use sampled evidence to infer abstract rules about the item distributions in containers and efficiently guide behaviour in novel test situations. In a third study, we investigated children's and capuchin monkeys' ability to integrate causal and social information when copying a goal-directed behaviour. Whereas children’s performance was mostly in line with the predictions of the computational models, showing that they are capable of abstraction and consider causal information when imitating, capuchin monkeys performed in all experiments at chance and chimpanzees showed some understanding of abstract rules.

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Workshop / Seminar Fri, 02 Oct 2020 15:51:03 -0400 2020-10-05T14:30:00-04:00 2020-10-05T15:30:00-04:00 Off Campus Location Weinberg Institute for Cognitive Science Workshop / Seminar
Honors Seminar Series: Julie Boland (October 7, 2020 2:00pm) https://events.umich.edu/event/76512 76512-19719173@events.umich.edu Event Begins: Wednesday, October 7, 2020 2:00pm
Location: Off Campus Location
Organized By: LSA Honors Program

Conversation usually seems effortless, but the rapid transitions between speakers entail multi-tasking that challenges our understanding of attention and working memory. In my lab, we've been conducting experiments to better understand this puzzle and I will describe some of our recent results

Please join us by registering for this event here: https://myumi.ch/0W1Op

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Workshop / Seminar Tue, 29 Sep 2020 14:18:04 -0400 2020-10-07T14:00:00-04:00 2020-10-07T15:00:00-04:00 Off Campus Location LSA Honors Program Workshop / Seminar Photo of Julie Boland
DCMB / CCMB Weekly Seminar (October 7, 2020 4:00pm) https://events.umich.edu/event/78232 78232-19996937@events.umich.edu Event Begins: Wednesday, October 7, 2020 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract: The chromosomes of the human genome are organized in three-dimensions by compartmentalizing the cell nucleus and different genomic loci also interact with each other. However, the principles underlying such nuclear genome organization and its functional impact remain poorly understood. In this talk, I will introduce some of our recent work in developing machine learning methods by utilizing whole-genome mapping data to study the higher-order genome organization. Our methods reveal the spatial localization of chromosome regions and exploit chromatin interactome patterns within the cell nucleus in different cellular conditions, across mammalian species, and also in single-cell resolution. We hope that these algorithms will provide new insights into the principles of nuclear spatial organization.

Bio: Jian Ma is an Associate Professor in the Computational Biology Department within the School of Computer Science at Carnegie Mellon University. He was previously on the faculty of the University of Illinois at Urbana-Champaign. His lab develops algorithms to study the structure and function of the human genome with a focus on nuclear organization, gene regulation, comparative genomics, and single cell biology. He received several awards, including an NSF CAREER award and a Guggenheim Fellowship. He is the Contact PI of a UM1 Center project in the NIH 4D Nucleome Program (Phase 2; 2020-2025). https://www.cs.cmu.edu/~jianma/

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Tue, 06 Oct 2020 12:47:39 -0400 2020-10-07T16:00:00-04:00 2020-10-07T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual
Engineering an immunological niche for early detection of immune dysfunction (October 8, 2020 12:00pm) https://events.umich.edu/event/77515 77515-19877791@events.umich.edu Event Begins: Thursday, October 8, 2020 12:00pm
Location: Off Campus Location
Organized By: Office of Research School of Dentistry

Lonnie Shea, PhD
William and Valerie Hall Chair
Steven A. Goldstein Collegiate Professor
Biomedical Engineering
University of Michigan

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Presentation Mon, 21 Sep 2020 13:40:07 -0400 2020-10-08T12:00:00-04:00 2020-10-08T13:00:00-04:00 Off Campus Location Office of Research School of Dentistry Presentation flyer
BME Seminar Series: Nathan Price (October 8, 2020 4:00pm) https://events.umich.edu/event/75906 75906-19623824@events.umich.edu Event Begins: Thursday, October 8, 2020 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Join us for our virtual seminar series on Thursdays from 4-5pm!
These events will take place on BlueJeans at this link: https://bluejeans.com/628109990

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Workshop / Seminar Thu, 20 Aug 2020 14:01:08 -0400 2020-10-08T16:00:00-04:00 2020-10-08T17:00:00-04:00 Off Campus Location Biomedical Engineering Workshop / Seminar BME
Biophysics Virtual Seminar Series (October 9, 2020 12:00pm) https://events.umich.edu/event/76961 76961-19782523@events.umich.edu Event Begins: Friday, October 9, 2020 12:00pm
Location: Off Campus Location
Organized By: LSA Biophysics

*Please see below for the link to join the Zoom livestream*

The Biophysics Virtual Seminar Series Presents:

Hong Qian - Olga Jung Wan Endowed Professor of Applied Mathematics, Department of Applied Mathematics, University of Washington

“A Mathematical Principle of Stochastic Chemical Kinetics and
Emergent Chemical Thermodynamics that Applies to Living Cells”

Abstract: In contrast to featureless point masses in Mechanics, a macromolecule in biochemistry has a large number of internal degrees of freedom in terms of atoms. The behavior of even a single protein in an aqueous environment, is often so complex that the mathematical representation of biochemical kinetics has to be statistical. In this talk, I present a stochastic formulation of general chemical reaction systems, with *N* species and *M* stochastic elementary reactions in solution and show how J. W. Gibbs’ macroscopic equilibrium chemical thermodynamics can be derived as a mathematical result, with an entropic force as its center piece. Our theory is actually applicable to mesoscopic open chemical systems with a chemostat, such as a single living cell. I then discuss the application of this theory to understand the notion of non-genetic phenotype switching, in terms of a landscape, in cell differentiation and cancer heterogeneity.

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Livestream / Virtual Fri, 09 Oct 2020 10:27:08 -0400 2020-10-09T12:00:00-04:00 2020-10-09T13:00:00-04:00 Off Campus Location LSA Biophysics Livestream / Virtual Zoom Passcode: Biophysics
MCDB Virtual Seminar: Structural Insights into TRP channels gating (October 9, 2020 12:00pm) https://events.umich.edu/event/77386 77386-19846073@events.umich.edu Event Begins: Friday, October 9, 2020 12:00pm
Location: Off Campus Location
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Randy Stockbridge

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Workshop / Seminar Thu, 08 Oct 2020 16:06:20 -0400 2020-10-09T12:00:00-04:00 2020-10-09T14:00:00-04:00 Off Campus Location Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB-initials-and-microscope-in yellow on a blue square
Economic Theory: Scoring Strategic Agents (October 9, 2020 2:30pm) https://events.umich.edu/event/81677 81677-20941461@events.umich.edu Event Begins: Friday, October 9, 2020 2:30pm
Location: Off Campus Location
Organized By: Department of Economics

Abstract
I introduce a model of predictive scoring. A receiver wants to predict a sender’s quality. An intermediary observes multiple features of the sender and aggregates them into a score. Based on the score, the receiver takes a decision. The sender wants the most favorable decision, and she can distort each feature at a privately known cost. I characterize the most accurate scoring rule. This rule underweights some features to deter sender distortion, and overweights other features so that the score is correct on average. The receiver prefers this score to full disclosure because the aggregated information mitigates his commitment problem.

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Workshop / Seminar Wed, 03 Feb 2021 11:42:44 -0500 2020-10-09T14:30:00-04:00 2020-10-09T15:50:00-04:00 Off Campus Location Department of Economics Workshop / Seminar Econ Umich
Hands-on Workshop: Creating a Hybrid Simulation System Using the Simple Run Time Infrastructure Software (October 9, 2020 4:00pm) https://events.umich.edu/event/76684 76684-19735053@events.umich.edu Event Begins: Friday, October 9, 2020 4:00pm
Location: Off Campus Location
Organized By: Michigan Institute for Computational Discovery and Engineering

The goal of this hands-on workshop is to introduce the Simple Run-Time Infrastructure software toolkit (SRTI) to the participants, and provide a template project consisting of multiple simulators, each with a specialized purpose, relating to a natural-disaster scenario. It will take place after the feature talks.

The SRTI is a free, open-source solution developed at the University of Michigan, and enables researchers to connect computer programs and simulators written in different languages, to share data during execution, and to design hybrid systems using disparate simulator modules, with a primary goal of being user friendly. This hands-on workshop will explain what the SRTI is, and provide an example on how to use it.

The Java Runtime Environment (JRE) is required to run the SRTI. Please install it prior to the workshop. Refer to icor.engin.umich.edu for more information on supported operating systems and languages. Participants will need to use their own computer systems at home to take part. Basic coding skills in any programming language are required.

Open to the general public. Please register if you wish to participate.

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Workshop / Seminar Thu, 03 Sep 2020 16:10:17 -0400 2020-10-09T16:00:00-04:00 2020-10-09T18:00:00-04:00 Off Campus Location Michigan Institute for Computational Discovery and Engineering Workshop / Seminar Creating a Hybrid Simulation System Using the Simple Run Time Infrastructure Software
Honors Seminar Series: Sara Fitzgerald (October 12, 2020 2:00pm) https://events.umich.edu/event/75960 75960-19629761@events.umich.edu Event Begins: Monday, October 12, 2020 2:00pm
Location: Off Campus Location
Organized By: LSA Honors Program

In 1970, as Michigan prepared to celebrate the 100th anniversary of the admission of women, women faculty at U.S. colleges were exempted from the protections of the major civil rights laws and the U-M admissions office was enforcing a 55:45 quota on male-female admissions to ensure that there would not be an “overbalance” of women in the freshman class. But a small group of Ann Arbor women developed a strategy to unleash the power of the federal government to demand change at U-M by threatening to withhold millions of dollars in federal contracts. The settlement provided the model for resolving similar complaints at dozens of other universities in the years immediately before the passage of Title IX. Sara Fitzgerald, then an Honors history major, covered the controversy for The Michigan Daily, and a half-century later, reflects on how that time on campus shaped her own career aspirations and writing interests.

Author of "Conquering Heroines", and Honors alumna, Sara Fitzgerald is a former editor and new-media developer for the Washington Post and was the first woman to serve as editor-in-chief of the Michigan Daily. She is the author of Elly Peterson: “Mother” of the Moderates (University of Michigan Press, 2012) and The Poet’s Girl (Thought Catalog Books, 2020).

Please register for this event here: https://myumi.ch/0W1Op

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Workshop / Seminar Tue, 29 Sep 2020 14:26:32 -0400 2020-10-12T14:00:00-04:00 2020-10-12T15:00:00-04:00 Off Campus Location LSA Honors Program Workshop / Seminar Photo of Sara Fitzgerald
The Evolution of Basketball with Data Science (October 12, 2020 4:00pm) https://events.umich.edu/event/78271 78271-20002854@events.umich.edu Event Begins: Monday, October 12, 2020 4:00pm
Location: Off Campus Location
Organized By: Michigan Institute for Data Science

For the last couple of decades, most industries have grown to take advantage of the information gained from data collection. As that happened, professional sports teams started to catch on. Baseball took the lead thanks to the amount of data collected over the years, which dates to the 1800s, but a lot of other professional sports followed and put more attention to their data collection. With technological advancements, particularly high-speed cameras, storage capacities and image recognition, more dynamic sports started to collect richer and richer data. The insights derived from this data started shifting the way the game is played and the way players are evaluated. This talk will take you through the evolution of data science in basketball and give examples of how data is shifting the way teams make decisions on and off the court.

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Presentation Wed, 07 Oct 2020 09:55:02 -0400 2020-10-12T16:00:00-04:00 2020-10-12T17:00:00-04:00 Off Campus Location Michigan Institute for Data Science Presentation https://umich.zoom.us/j/94496488704
How Lean Culture is Fighting Against the Coronavirus (October 12, 2020 4:30pm) https://events.umich.edu/event/78063 78063-19957560@events.umich.edu Event Begins: Monday, October 12, 2020 4:30pm
Location: Off Campus Location
Organized By: Center for Healthcare Engineering & Patient Safety (CHEPS)

We’ve all been impacted by the COVID-19 pandemic in different ways. For me, one of the ways was receiving a call to “deploy” to our ventilator manufacturing facility to help make an unprecedented volume of ventilators as fast as possible. The world needed ventilators to fight COVID-19 and we needed to ramp production using our best manufacturing methodologies.Using Lean techniques was once described by one of its founding leaders, Taiichi Ohno, as “looking at the timeline, from the moment the customer gives us an order to the point when we collect the cash. And we are reducing the timeline by reducing the non-value adding wastes.” GE Healthcare has incorporated Lean into its operational fabric just as described in the quote to delivery reliable daily output as well as to take on new manufacturing challenges. In this presentation, I will describe the challenge that COVID-19 presented to our company, to the production process & to the cross-functional group of people involved in supporting production. To tell this story, I will be sharing some basics about Lean Methodologies and how it influenced our approach, communications & the execution of an unprecedented ventilator output. Finally, I will discuss how these same methodologies and approach can be used to positively impact your business, career, or challenge you’re facing.

Passion: My passion is serving the Healthcare community by educating eager learners, utilizing Lean-6 Sigma methodologies & incorporating Advanced Technologies to challenge the status quo & bring about meaningful improvement.

Experience: I’ve been with GE Healthcare for 15 years in a variety of roles from a manufacturing engineer, to a site & national Lean Leader to a multi-state field service director. These roles have including manufacturing, service & commercial elements to them and always included a primary focus on healthcare. Additionally, I have worked within the aviation, energy & financial industries through cross-business projects. With my experience, I was recently called on by GE to help during the COVID-19 response to drive increased output, improved quality & to build a supportive culture in our ventilator manufacturing business. Additionally, I have used this knowledge to start an education & consulting group focused on Lean methodologies called ripple Solutions LLC. My small business has allowed me to expand outside of healthcare & connect with the printing, distribution, university & non-healthcare manufacturing industries.

Education: I have a degree in Industrial Engineering with additional courses in Medical Sciences from University of Michigan, class of 2007. I am a GE Healthcare Operations Management Leadership Program graduate, I’m a certified Black Belt in DMAIC Lean Six Sigma and I’m Green Belt certified in DFSS Six Sigma. I have also received extensive GE Healthcare & Shingijtsu Lean training.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach. For the Zoom link and password and to be added to the weekly e-mail for the series, please RSVP. For additional questions, contact CHEPSseminar@umich.edu. Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Thu, 01 Oct 2020 14:52:38 -0400 2020-10-12T16:30:00-04:00 2020-10-12T17:30:00-04:00 Off Campus Location Center for Healthcare Engineering & Patient Safety (CHEPS) Lecture / Discussion photo of speaker with event information
DCMB / CCMB Weekly Seminar (October 14, 2020 4:00pm) https://events.umich.edu/event/78234 78234-19996940@events.umich.edu Event Begins: Wednesday, October 14, 2020 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract: Gaussian processes provide flexible non-parametric models of data and we are using them to model temporal and spatial patterns in gene expression. Single-cell omics measurements are destructive and one cannot follow the high-dimensional dynamics of genes across time in one cell. Similarly, the spatial context of cells is often lost or only known with reduced resolution. Computational methods are widely used to infer pseudo-temporal orderings of cells or to infer spatial locations. We show how Gaussian processes (GPs) can be used to model temporal and spatial relationships between genes and cells in these datasets. As examples I will show how we use Bayesian GPLVMs with informative priors to infer pseudo-temporal orderings for single-cell time course data [1] and branching GPs to identify gene-specific bifurcation points across pseudotime [2]. Gene expression data are often summarized as counts and there may be many zero values in the data due to limited sequencing depth. We therefore recently extended these methods to use negative binomial or zero-inflated negative binomial likelihoods and we show that this can lead to much improved performance over standard Gaussian noise models when identifying spatially varying genes from spatial transcriptomics data [3].

[1] Ahmed, S., Rattray, M., & Boukouvalas, A. (2019). GrandPrix: scaling up the Bayesian GPLVM for single-cell data. Bioinformatics, 35(1), 47-54.

[2] Boukouvalas, A., Hensman, J., & Rattray, M. (2018). BGP: identifying gene-specific branching dynamics from single-cell data with a branching Gaussian process. Genome biology, 19(1), 65.

[3] BinTayyash, N., Georgaka, S., John, S. T., Ahmed, S., Boukouvalas, A., Hensman, J., & Rattray, M. (2020). Non-parametric modelling of temporal and spatial counts data from RNA-seq experiments. Bioarxiv https://doi.org/10.1101/2020.07.29.227207

Short bio: Magnus Rattray is Professor of Computational and Systems Biology at the University of Manchester and Director of the Institute for Data Science & AI. He works on the development of methods for machine learning and Bayesian inference with applications to large-scale biological and medical datasets. He has a long-standing interest in longitudinal data analysis and a more recent interest in modelling single-cell, spatial omics and live cell imaging microscopy data. He is a Fellow of the ELLIS Health Programme and the Alan Turing Institute and his research is funded by a Wellcome Trust Investigator Award.

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Tue, 06 Oct 2020 13:35:21 -0400 2020-10-14T16:00:00-04:00 2020-10-14T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual Magnus Rattray, PhD (Professor of Computational and Systems Biology, University of Manchester)
Michael Beauregard Seminar in Macroeconomics: The Global Financial Resource Curse (October 14, 2020 4:00pm) https://events.umich.edu/event/78087 78087-19963473@events.umich.edu Event Begins: Wednesday, October 14, 2020 4:00pm
Location: Off Campus Location
Organized By: Department of Economics

Abstract:
Since the late 1990s, the United States has received large capital flows from developing countries - a phenomenon known as the global saving glut - and experienced a productivity growth slowdown. Motivated by these facts, we provide a model connecting international financial integration and global productivity growth. The key feature is that the tradable sector is the engine of growth of the economy. Capital flows from developing countries to the United States boost demand for U.S. non-tradable goods, inducing a reallocation of U.S. economic activity from the tradable sector to the non-tradable one. In turn, lower profits in the tradable sector lead firms to cut back investment in innovation. Since innovation in the United States determines the evolution of the world technological frontier, the result is a drop in global productivity growth. This effect, which we dub the global financial resource curse,
can help explain why the global saving glut has been accompanied by subdued investment and growth, in spite of low global interest rates.

*To join the seminar, please contact at econ.events@umich.edu

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Workshop / Seminar Fri, 02 Oct 2020 08:42:47 -0400 2020-10-14T16:00:00-04:00 2020-10-14T17:00:00-04:00 Off Campus Location Department of Economics Workshop / Seminar Econ Umich
3D organization of human genome in development and disease – A perspective from 3D genome engineering (October 15, 2020 12:00pm) https://events.umich.edu/event/78431 78431-20044394@events.umich.edu Event Begins: Thursday, October 15, 2020 12:00pm
Location: Off Campus Location
Organized By: Office of Research School of Dentistry

Xiaotian Zhang, PhD
Research Investigator
Department of Pathology
Tomasz Cierpicki/Jolanta Grembecka lab
University of Michigan

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Lecture / Discussion Mon, 12 Oct 2020 12:04:51 -0400 2020-10-15T12:00:00-04:00 2020-10-15T13:00:00-04:00 Off Campus Location Office of Research School of Dentistry Lecture / Discussion Zhang
Biophysics Seminar Series (October 16, 2020 12:00pm) https://events.umich.edu/event/77916 77916-19941582@events.umich.edu Event Begins: Friday, October 16, 2020 12:00pm
Location: Off Campus Location
Organized By: LSA Biophysics

*Please see below for the link to join the Zoom event.*

The Biophysics Virtual Seminar Series presents:

Dr. Jamie Cate - Professor of Molecular & Cell Biology, and Chemistry,
University of California - Berkeley

“Selective modulation of human translation: potential for new therapeutics”

ABSTRACT: Small molecules that target the ribosome such as antibiotics generally impact a substantial fraction of the proteome. We recently identified a class of small molecules that bind the human ribosome and selectively stall the translation of a small subset of proteins. I will present biochemical and cell-based experiments, along with structures of human ribosome nascent chain complexes (RNCs) stalled by these compounds, determined by cryo-electron microscopy (cryo-EM). These small molecules bind in the ribosome exit tunnel in a eukaryotic-specific pocket formed by the 28S ribosomal RNA (rRNA) and arrest the translating ribosome through their interactions with the growing polypeptide chain. Intriguingly, a given compound can either inhibit or enhance translation, depending on the sequence of the protein nascent chain. These results begin to reveal how small molecules can be made to control human translation and suggest a new strategy for developing small molecules that selectively inhibit or enhance the production of proteins previously considered “undruggable.”

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Livestream / Virtual Thu, 08 Oct 2020 12:47:14 -0400 2020-10-16T12:00:00-04:00 2020-10-16T13:00:00-04:00 Off Campus Location LSA Biophysics Livestream / Virtual Dr. Jamie Cate
MCDB Virtual Seminar: Neural circuit mechanisms and technology for pain and social touch (October 16, 2020 12:00pm) https://events.umich.edu/event/77404 77404-19848066@events.umich.edu Event Begins: Friday, October 16, 2020 12:00pm
Location: Off Campus Location
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Behaar Chawla

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Workshop / Seminar Thu, 08 Oct 2020 16:10:22 -0400 2020-10-16T12:00:00-04:00 2020-10-16T14:00:00-04:00 Off Campus Location Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Ishmail with books background
Economic Theory: Selling two identical objects (Joint work with Sushil Bikhchandani) (October 16, 2020 1:00pm) https://events.umich.edu/event/81678 81678-20941462@events.umich.edu Event Begins: Friday, October 16, 2020 1:00pm
Location: Off Campus Location
Organized By: Department of Economics

Abstract
It is well-known that optimal (i.e., revenue-maximizing) selling mechanisms in multidimensional type spaces may involve randomization. We study mechanisms for selling two identical, indivisible objects to a single buyer. We analyze two settings: (i) decreasing marginal values (DMV) and (ii) increasing marginal values (IMV). Thus, the two marginal values of the buyer are not independent. We obtain sufficient conditions on the distribution of buyer values for the existence of an optimal mechanism that is deterministic.
In the DMV model, we show that under a well-known condition, it is optimal to sell the first unit deterministically. Under the same sufficient condition, a bundling mechanism (which is deterministic) is optimal in the IMV model. Under a stronger sufficient condition, a deterministic mechanism is optimal in the DMV model.
Our results apply to heterogenous objects when there is a specified sequence in which the two objects must be sold.

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Workshop / Seminar Wed, 03 Feb 2021 11:46:18 -0500 2020-10-16T13:00:00-04:00 2020-10-16T14:20:00-04:00 Off Campus Location Department of Economics Workshop / Seminar Econ Umich
Economics at Work (October 16, 2020 1:00pm) https://events.umich.edu/event/78077 78077-19957576@events.umich.edu Event Begins: Friday, October 16, 2020 1:00pm
Location: Off Campus Location
Organized By: Department of Economics

Economics@Work is intended for any student who is interested in learning about a variety of career opportunities for economics majors. Early students of economics may use this class to explore whether an economics major best suits their interests and goals. Advanced students in economics will benefit from the information and networking opportunities.

To join the seminar, please register from the following link.
https://forms.gle/wAegqGt6tqkWaXdx9

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Workshop / Seminar Thu, 01 Oct 2020 17:18:23 -0400 2020-10-16T13:00:00-04:00 2020-10-16T14:30:00-04:00 Off Campus Location Department of Economics Workshop / Seminar Econ Umich
Towards an Artificial Intuition: Conversational Markers of (Anti)Social Dynamics (October 19, 2020 4:00pm) https://events.umich.edu/event/78274 78274-20002858@events.umich.edu Event Begins: Monday, October 19, 2020 4:00pm
Location: Off Campus Location
Organized By: Michigan Institute for Data Science

Can conversational dynamics—the nature of the back and forth between people—predict outcomes of social interactions? This talk will describe efforts on developing an artificial intuition about ongoing conversations, by modeling the subtle pragmatic and rhetorical choices of the participants.
The resulting framework distills emerging conversational patterns that can point to the nature of the social relation between interlocutors, as well as to the future trajectory of this relation. For example, I will discuss how interactional dynamics can be used to foretell whether an online conversation will stay on track or eventually derail into personal attacks, providing community moderators several hours of prior notice before an anti-social event is likely to occur.
The data and code are available through the Cornell Conversational Analysis Toolkit (ConvoKit): http://convokit.cornell.edu
This talk includes joint work with Jonathan P. Chang, Lucas Dixon, Liye Fu, Yiqing Hua, Dan Jurafsky, Lillian Lee, Jure Leskovec, Vlad Niculae, Chris Potts, Arthur Spirling, Dario Taraborelli, Nithum Thain, and Justine Zhang.

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Presentation Wed, 07 Oct 2020 10:03:41 -0400 2020-10-19T16:00:00-04:00 2020-10-19T17:00:00-04:00 Off Campus Location Michigan Institute for Data Science Presentation https://umich.zoom.us/j/95443347994
Tracking A Pandemic: An Analytical View of the COVID-19 Progression and Implications for Business Plans to Re-Engage in the Economy (October 19, 2020 4:30pm) https://events.umich.edu/event/78333 78333-20010773@events.umich.edu Event Begins: Monday, October 19, 2020 4:30pm
Location: Off Campus Location
Organized By: Center for Healthcare Engineering & Patient Safety (CHEPS)

The SARS-CoV-2 virus caused widespread disruption across the globe, affecting literally every aspect of human life. The business environment was not spared in this disruption, as customers, the workforce, workplace environments and supply chains were each turned upside-down, almost overnight. Operating practices needed to be challenged, re-engineered and re-adopted – at the speed of business. That is akin to replacing the aircraft engine while the plane is mid-flight.

The challenge faced by business leaders from the outset of the pandemic, and remains true today, is that objective, analytical information on the state of the virus was and remains woefully inadequate. Further, every organization operating in multiple geographical and political jurisdictions has to navigate different and every-changing rules governing the ability to conduct operations.

In mid-March, I launched an effort to build a repository of critical virus-related information (tests, positives, infections, recoveries, fatalities) at various levels of granularity – world, country, state or province, and metropolitan area. From this, I established a daily reporting mechanism and underlying analyses, designed to equip business leaders, economic and investment advisors and clinicians with insight about the state of the virus spread and underlying trends. My intent was to inform these leaders with actionable intelligence, free of both the fearmongering and denial perspectives that were dominating the general and social media.

These efforts have resulted in my direct engagement with four organizations’ operational planning efforts around the pandemic: two for-profit organizations involved in the manufacture and distribution of critical medical/life sciences products to consumers around the globe, a not-for-profit agency supporting families of critically-ill children and a governmental agency charged with administering a state-wide pandemic response effort. Additionally, I provide daily reports on the state of the virus to an estimated 2,000 clinicians, health organization managers, economists and investment managers.

These lessons provide strong insight for the analytical practitioner. Through this effort, I have discovered the challenges of making actionable sense of data from a novel virus . . . in real-time. Data sources and definitions are in constant flux, external reporting lacks analytical rigor, and, new knowledge frequently trumps previously held scientific beliefs. More profoundly, models reported on and used extensively by government officials are often accepted as dogma but, may be nothing more than assumptions built upon several more layers of assumptions.

Mark currently serves as the Board Chair of Crown Healthcare Laundry Inc., a Quilvest Private Equity-portfolio company and as Strategic Advisor to Terso Solutions Inc., a subsidiary of Promega that provides Real Time Location Services (RTLS) for field-based inventory of leading medical implant and biotech companies.

He previously served as chief strategist and business intelligence officer for Owens & Minor, Inc.; as a Partner in the healthcare consulting practice at Ernst & Young, where he launched the firm’s health care supply chain practice; and as a Management Engineer at the Detroit Medical Center.

Mark also serves on the National Advisory Board of the Congenital Heart Center at C.S. Mott Children’s Hospital at the University of Michigan, and on the Advisory Board of the Medical Device Supply Chain Council. He recently completed two terms on the Board of the Bellwether League Inc.

In the midst of the COVID-19 situation, Mark is producing an objective and analytical daily report on the virus progression in the US and worldwide. This report has become a go-to source for nearly 2,000 physicians, scientists, health system and supplier executives, economists, investment bankers and, one former head of the Centers for Medicare and Medicaid Services.

Mark holds an MBA from the Ross School of Business at the University of Michigan and a Bachelor of Science in Industrial & Operations Engineering, also from the University of Michigan.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach. For the Zoom link and password and to be added to the weekly e-mail for the series, please RSVP. For additional questions, contact CHEPSseminar@umich.edu. Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Thu, 08 Oct 2020 11:38:55 -0400 2020-10-19T16:30:00-04:00 2020-10-19T17:30:00-04:00 Off Campus Location Center for Healthcare Engineering & Patient Safety (CHEPS) Lecture / Discussion photo of speaker with event information
CSCS/MIDAS/MICDE Seminar | Predicting the second wave of COVID-19 in Washtenaw County, MI (October 20, 2020 11:30am) https://events.umich.edu/event/76629 76629-19733025@events.umich.edu Event Begins: Tuesday, October 20, 2020 11:30am
Location: Off Campus Location
Organized By: The Center for the Study of Complex Systems

This seminar is co-sponsored by the Michigan Institute for Computational Discovery & Engineering (MICDE) and the Michigan Institute for Data Science (MIDAS)

VIRTUAL SEMINAR LINK: myumi.ch/v2ZYv

In this work, we study and predict the spread of COVID-19 in Washtenaw County, MI through applying a discrete and stochastic network-based modeling framework. In this framework, we construct contact networks based on synthetic population datasets specific for Washtenaw County that are derived from US Census datasets. We assign individuals to households, workplaces, schools, and group quarters (such as prisons or long term care facilities). In addition, we assign casual contacts to each individual at random. Using this framework, we explicitly simulate Michigan-specific government-mandated workplace and school closures as well as social distancing measures. We perform sensitivity analyses to identify key model parameters and mechanisms contributing to the observed disease burden in the three months following the first observed cases of COVID-19 in Michigan. We then consider several scenarios for relaxing restrictions and reopening workplaces to predict what actions would be most prudent. In particular, we consider the effects of 1) different timings for reopening, and 2) different levels of workplace vs. casual contact re-engagement. Through simulations and sensitivity analyses, we explore mechanisms driving the magnitude and timing of a second wave of infections upon re-opening.

This work is based on Dr. Renardy's *paper in press* in the *Journal of Theoretical Biology* with coauthors:
Marisa Eisenberg, UM Complex Systems & Math (LSA) and Epidemiology (Public Health)
Denise Kirschner, UM Department of Microbiology & Immunology (Medical School)

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Livestream / Virtual Mon, 28 Sep 2020 14:00:42 -0400 2020-10-20T11:30:00-04:00 2020-10-20T13:00:00-04:00 Off Campus Location The Center for the Study of Complex Systems Livestream / Virtual Photo of Marissa Renardy
Human Capital, History, Demography & Development (H2D2): Structural Change, Inequality, and Capital Flows (October 20, 2020 11:30am) https://events.umich.edu/event/78689 78689-20105425@events.umich.edu Event Begins: Tuesday, October 20, 2020 11:30am
Location: Off Campus Location
Organized By: Department of Economics

To join the seminar, please visit the following webpage.
https://sites.google.com/view/h2d2/seminars

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Workshop / Seminar Tue, 20 Oct 2020 11:31:14 -0400 2020-10-20T11:30:00-04:00 2020-10-20T12:50:00-04:00 Off Campus Location Department of Economics Workshop / Seminar Econ Umich
LHS Collaboratory-LHS as a Driver of Diversity, Equity, and Inclusion (October 20, 2020 11:30am) https://events.umich.edu/event/77545 77545-19879862@events.umich.edu Event Begins: Tuesday, October 20, 2020 11:30am
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Healthcare and health remain unconscionably inequitable. This year, the disproportionate toll the COVID-19 pandemic has taken on those historically least well-served by our health system, has highlighted the pressing societal challenge of health disparities.

Beyond simply striving to do no harm, Learning Health Systems (LHSs) have the potential to serve as forces for justice in healthcare and health; indeed, they can be powerful drivers of diversity, equity, and inclusion. LHSs are anchored in multi-stakeholder consensus Core Values that explicitly incorporate principles such as inclusiveness, transparency, and accessibility. Their proximal goal is "to efficiently and equitably serve the learning needs of all participants, as well as the overall public good."

The October 2020 LHS Collaboratory will share lessons from health advocates working on the front lines to make healthcare and health more equitable. These thought leaders and do-ers will illuminate the transformative power of LHSs - and the diverse and inclusive communities of interest that are collaborating to realize them.

Moderator:
Joshua C. Rubin, JD, MBA, MPP, MPH
Program Officer, Learning Health System Initiatives, Department of Learning Health Sciences, University of Michigan

Panelists:
Luis Belén
Chief Executive Officer of the National Health IT Collaborative for the Underserved (NHIT Collaborative)

Danielle Brooks, JD
Director of Health Equity, Amerihealth Caritas

Melissa S. Creary, PhD, MPH, Assistant Professor
Department of Health Management and Policy
School of Public Health, University of Michigan

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Lecture / Discussion Sun, 27 Sep 2020 21:18:37 -0400 2020-10-20T11:30:00-04:00 2020-10-20T13:00:00-04:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion LHS Collaboratory Logo puzzle pieces
CCAT Distinguished Lecture Series (October 21, 2020 1:00pm) https://events.umich.edu/event/78174 78174-19989054@events.umich.edu Event Begins: Wednesday, October 21, 2020 1:00pm
Location: Off Campus Location
Organized By: Center for Connected and Automated Transportation

After a long hiatus due to the COVID-19 pandemic, the CCAT Distinguished Lecture Series returns virtually this October with Trevor Pawl!

On July 2nd, Michigan Governor Gretchen Whitmer formally announced the launch of the Office of Future Mobility and Electrification (OFME) with Trevor Pawl named as Chief Mobility Officer. Trevor will provide insight into the creation of OFME, its vision, and its use as a tool for all key mobility stakeholders in Michigan. This webinar will include a Q&A session.
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About the speaker: Trevor Pawl is the Chief Mobility Officer for the State of Michigan, and leads Michigan’s Office of Future Mobility and Electrification. In this position, Pawl is responsible for working across state government, academia and private industry to grow Michigan’s mobility ecosystem through strategic policy recommendations and new support services for companies focused on the future of transportation. Prior to this position, Pawl served as the Senior Vice President of Business Innovation at the MEDC, where he led the official state programs for mobility (PlanetM), supply chain assistance (Pure Michigan Business Connect), export assistance (Michigan International Trade program) and entrepreneurial assistance (Michigan Entrepreneurship and Innovation Program). Before joining the MEDC, Pawl brought with him experience in supply chain matchmaking, having led the creation of the economic development program, Connection Point, at the Detroit Regional Chamber, which later became Pure Michigan Business Connect. Trevor has been named Crain’s Detroit Business’s “40 Under 40” and “50 Names to Know in Government”. He’s also been named Development Counsellors International’s “40 Under 40 Rising Stars of Economic Development” and the Great Lakes Women’s Business Council’s “Government Advocate of the Year”. Pawl holds a Bachelor’s degree in Economics and Marketing from Grand Valley State University and a Master of Business Administration from the University of Detroit Mercy.

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Lecture / Discussion Mon, 05 Oct 2020 16:35:03 -0400 2020-10-21T13:00:00-04:00 2020-10-21T14:00:00-04:00 Off Campus Location Center for Connected and Automated Transportation Lecture / Discussion Decorative Image
Data Science Coast to Coast Presents: Talitha Washington (October 21, 2020 3:00pm) https://events.umich.edu/event/78280 78280-20002864@events.umich.edu Event Begins: Wednesday, October 21, 2020 3:00pm
Location: Off Campus Location
Organized By: Michigan Institute for Data Science

The DS C2C seminar series, hosted jointly by six academic data science institutes, provides a unique opportunity to foster a broad-reaching data science community.

Speakers include faculty members and postdoctoral fellows at the six institutes whose research spans the theory and methodology of data science, and their application in arts and humanities, engineering, biomedical, natural, physical and social sciences.

In addition, the series features some of the most important figures in data science, who will provide insight on the transformative use of data science in traditional research disciplines, future breakthroughs in data science research, data science entrepreneurship, and advocacy and national policies for a data-enabled and just society.

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Presentation Wed, 07 Oct 2020 11:23:52 -0400 2020-10-21T15:00:00-04:00 2020-10-21T17:00:00-04:00 Off Campus Location Michigan Institute for Data Science Presentation https://umich.zoom.us/j/93769972428
MIPSE Seminar | Bringing Cosmic Shock Waves Down to Earth (October 21, 2020 3:30pm) https://events.umich.edu/event/76462 76462-19717156@events.umich.edu Event Begins: Wednesday, October 21, 2020 3:30pm
Location: Off Campus Location
Organized By: Michigan Institute for Plasma Science and Engineering (MIPSE)

The seminar is free and open to the public.
To request the Zoom link, please send an email to:
mipse-central@umich.edu

Abstract:
As a fundamental process for converting kinetic to thermal energy, collisionless shocks are ubiquitous throughout the heliosphere and astrophysical systems, from Earth’s magneto-sphere to supernova remnants. While these shocks have been studied for decades by spacecraft, telescopes, and numerical simulations, there remain key open questions in shock physics, such as: How do shocks accelerate particles to extremely high energies? or How are particles heated across a shock? Laboratory experiments thus provide a significant opportunity to both complement spacecraft and remote sensing observations with well-controlled and well-diagnosed datasets, and to help benchmark numerical simulations that bridge laboratory and astrophysical systems.

In this talk, I will discuss recent results from experiments and simulations on the formation and evolution of collision-less shocks created through the interaction of a supersonic laser-driven magnetic piston and magnetized ambient plasma. Through advanced diagnostics a fast, high-Mach-number shock is observed. Direct probing of particle velocity distributions reveals the coupling between the piston and ambient plasmas that is a key step in forming magnetized collisionless shocks. Particle-in-cell simulations further detail the shock formation process, the role of collisionality, and the dynamics of multi-ion-species ambient plasmas. I will also discuss how this experimental platform complements spacecraft missions and can allow novel investigations of shock heating and particle acceleration.

About the Speaker:
Dr. Schaeffer is an Associate Research Scholar in the Department of Astrophysical Sciences at Princeton University. He received his BA in Physics at Cornell University and his PhD in Physics from UCLA, and did his postdoctoral work at Princeton in high-energy-density laboratory astrophysics. Dr. Schaeffer has extensive experience in experiments involving magnetized laser plasmas, collisionless shocks, and magnetic reconnection, and a keen interest in bridging laboratory and astronomical observations. He also has expertise in a wide range of diagnostics, including Thomson scattering, refractive imaging, proton radiography, and x-ray imaging. He has authored dozens of papers and has presented at numerous conferences around the world.

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Livestream / Virtual Tue, 01 Sep 2020 10:51:04 -0400 2020-10-21T15:30:00-04:00 2020-10-21T16:30:00-04:00 Off Campus Location Michigan Institute for Plasma Science and Engineering (MIPSE) Livestream / Virtual Dr. Derek Schaeffer
DCMB / CCMB Weekly Seminar (October 21, 2020 4:00pm) https://events.umich.edu/event/78531 78531-20058232@events.umich.edu Event Begins: Wednesday, October 21, 2020 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract
Although machine learning applications are now pervasive to every industry, adoption into healthcare remains a challenging and arduous process. Barriers to implementation include clinician trust, algorithm credibility and actionability, promoting clinician literacy in machine learning methods, and mitigating unintended consequences.

In the high-risk operating room setting, anesthesiologists are recognized leaders in patient safety, and manage uncertainty through careful considerations of risk and benefit based upon a thorough understanding of disease processes and treatment mechanisms. In this talk, the speaker highlights how obstacles to implementation of machine-learning based healthcare applications can be mitigated, and how an understanding of such applications can be promoted among clinically-minded anesthesiologists who may not necessarily be expert data scientists.

Short Bio:
Dr. Mathis has research interests in improving perioperative care for patients with advanced cardiovascular disease, particularly for patients with heart failure. As part of the Multicenter Perioperative Outcomes Group (MPOG), an international consortium of perioperative databases for which U-M serves as the coordinating center, he serves as Associate Research Director and plays a lead role in integration of MPOG data with data from national cardiac and thoracic surgery registries. He also has interests in leveraging novel data science methods to understand patterns within highly granular intraoperative physiologic data, studying hemodynamic responses to surgical and anesthetic stimuli as a means for early detection of cardiovascular diseases such as heart failure.

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Wed, 14 Oct 2020 11:43:15 -0400 2020-10-21T16:00:00-04:00 2020-10-21T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual Image which promotes the content of Dr. Mathis' talk (https://jamanetwork.com/collections/5584/critical-care-medicine)
BME Seminar Series: Tyrone Porter (October 22, 2020 4:00pm) https://events.umich.edu/event/75907 75907-19623825@events.umich.edu Event Begins: Thursday, October 22, 2020 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Join us for our virtual seminar series on Thursdays from 4-5pm!
These events will take place on BlueJeans at this link: https://bluejeans.com/628109990

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Workshop / Seminar Thu, 20 Aug 2020 14:06:51 -0400 2020-10-22T16:00:00-04:00 2020-10-22T17:00:00-04:00 Off Campus Location Biomedical Engineering Workshop / Seminar BME
Dr. Nahum Melamed on Asteroid Interception (October 22, 2020 7:00pm) https://events.umich.edu/event/78685 78685-20105421@events.umich.edu Event Begins: Thursday, October 22, 2020 7:00pm
Location: Off Campus Location
Organized By: American Institute of Aeronautics and Astronautics

Join the American Institute of Aeronautics and Astronautics this Thursday, October 22nd, for a lecture by Dr. Nahum Melamed on Applying Guidance, Navigation, and Controls Solutions to the Problem of Asteroid Interception for Planetary Defense.

Dr. Melamed is a project leader in the Embedded Control Systems Department in the Guidance and Control Subdivision at The Aerospace Corporation who validates and certifies the flight software and mission parameters for the Delta IV launch vehicles, and conducts planetary defense technical and policy studies. He earned a PhD in Aerospace Engineering from Georgia Tech.

If you're interested please add your name to the spreadsheet linked below.

When: Thursday, 22 October 2020 at 7pm ET (4pm PT)
Where: Zoom (see link below, passcode 424378)

We hope to see you there!!

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Lecture / Discussion Tue, 20 Oct 2020 10:08:36 -0400 2020-10-22T19:00:00-04:00 2020-10-22T20:15:00-04:00 Off Campus Location American Institute of Aeronautics and Astronautics Lecture / Discussion lecture flyer
Biophysics Seminar Series (October 23, 2020 12:00pm) https://events.umich.edu/event/77918 77918-19941583@events.umich.edu Event Begins: Friday, October 23, 2020 12:00pm
Location: Off Campus Location
Organized By: LSA Biophysics

*Please see below for the link to join the Zoom event.*

The Biophysics Virtual Seminar Series presents:

Dr. Sandra Schmid - Chief Scientific Officer, Chan Zuckerberg Biohub

“Dynamin: A catalyst for fission, collaboration and controversy”

ABSTRACT: Kazuo Ikeda’s beautiful electron micrographs of neuromuscular junctions of Drosophila *shibire* mutants revealed the presence of collar-like structures around the necks of trapped endocytic intermediates. They inspired my 30 year-long obsession with dynamin, the mammalian homologue of *shibire.* Our subsequent studies of dynamin, which began in the early 90s provide benefitted from the development of new technologies and from interdisciplinary collaboration. I’ll describe the twists and turns of our efforts to understand the mechanisms underlying dynamin-catalyzed fission, the value of interdisciplinary collaborations, and the importance of taking all data into account when formulating models. I’ll detail our current understanding of dynamin-catalyzed fission, now supported by independent studies of others, and briefly describe the many remaining unanswered questions, keeping in mind (in the words of George Box) that, *“All models are wrong, but some are useful."*

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Livestream / Virtual Mon, 19 Oct 2020 15:12:59 -0400 2020-10-23T12:00:00-04:00 2020-10-23T13:00:00-04:00 Off Campus Location LSA Biophysics Livestream / Virtual Dr. Sandra Schmid
Special Joint Seminar - Hosted by DCMB, Department of Mathematics, and the Smale Institute (October 26, 2020 12:00pm) https://events.umich.edu/event/78673 78673-20099541@events.umich.edu Event Begins: Monday, October 26, 2020 12:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Dr. Leland Hartwell won the Nobel Prize in Physiology or Medicine in 2001 for the discoveries of key regulators of the cell cycle.

“We want our students to have an authentic experience of science. Nearly all science activities designed for schools require the students to demonstrate an established scientific principle by getting the right answer. Getting the “right” answer is not authentic science. Science is the exploration of the unknown – the answer cannot be known.“
- Leland Hartwell

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Livestream / Virtual Mon, 19 Oct 2020 13:04:27 -0400 2020-10-26T12:00:00-04:00 2020-10-26T13:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual Dr. Leland Hartwell, Nobel Laureate
Fair Ranking with Biased Data (October 26, 2020 4:00pm) https://events.umich.edu/event/78276 78276-20002859@events.umich.edu Event Begins: Monday, October 26, 2020 4:00pm
Location: Off Campus Location
Organized By: Michigan Institute for Data Science

Search engines and recommender systems have become the dominant matchmaker for a wide range of human endeavors — from online retail to finding romantic partners. Consequently, they carry immense power in shaping markets and allocating opportunity to the participants. In this talk, I will discuss how the machine learning algorithms underlying these systems can produce unfair ranking policies for both exogenous and endogenous reasons. Exogenous reasons often manifest themselves as biases in the training data, which then get reflected in the learned ranking policy and lead to rich-get-richer dynamics. But even when trained with unbiased data, reasons endogenous to the algorithms can lead to unfair or undesirable allocation of opportunity. To overcome these challenges, I will present new machine learning algorithms that directly address both endogenous and exogenous unfairness.

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Presentation Wed, 07 Oct 2020 10:09:21 -0400 2020-10-26T16:00:00-04:00 2020-10-26T17:00:00-04:00 Off Campus Location Michigan Institute for Data Science Presentation https://umich.zoom.us/j/93790126046
Analyzing the Value of Flexibility in Design & Operations of Outpatient Health Centers (October 26, 2020 4:30pm) https://events.umich.edu/event/78742 78742-20115266@events.umich.edu Event Begins: Monday, October 26, 2020 4:30pm
Location: Off Campus Location
Organized By: Center for Healthcare Engineering & Patient Safety (CHEPS)

Although it is understood that healthcare systems are complex and dynamic systems, many times the operations of these systems, particularly around the allocation of fixed resources and physical space, is treated as fixed or static. As such policies regarding (i) the flow of patients, (ii) allocation of exam rooms, or (iii) the assignment of medical assistants to physicians are set at the beginning of the day, week or month, and remain unchanged across that duration. While the static nature of these schemes are meant to support stability and reduced complexity in the operations, this fixed mindset can hinder the ability to drive quality improvement. This presentation will review applications of simulation modeling in support of assessing the value that can be obtained from integrating flexibility into operational policies. We will review dynamic room allocation policies and staffing policies as applied to a crowded cardiovascular clinic. Additionally, we will explore similar concepts in multiple orthopedic clinics. Finally, we will present how these concepts can be similarly examined with a continuous-time Markov model.

Jackie Griffin is an Associate Professor in the Mechanical and Industrial Engineering Department at Northeastern University. Her research focuses on applications of Operations Research, Optimization, and Simulation methodologies in designing, managing and operating resilient healthcare delivery systems, ranging from outpatient clinics to regional emergency response networks to global pharmaceutical supply chains. Currently she leads a National Science Foundation funded project focused on tackling the ongoing challenge of drug shortages in the United States through the analysis of analytical models of pharmaceutical supply chains. Additionally, she has partnered with many prominent healthcare organizations to examine new strategies for improving the design and operation of health care systems while accounting for the need to balance multiple system objectives in ensuring delivery of high quality health care services. Her recent collaborations include organizations such as Massachusetts General Hospital, Tufts Medical Center, Boston Children’s Hospital, Beth Israel Hospital, Brigham and Women’s Hospital, and the IQVIA Institute for Human Data Science. Other past collaborators include the Centers for Disease Control and Prevention (CDC), Children’s Healthcare of Atlanta, DeKalb Medical Women’s Center, Emory University Hospital, Grady Memorial Hospital, and World Vision International. She received her PhD from the H. Milton Stewart School of Industrial and Systems Engineering at Georgia Institute of Technology. Additionally, she completed her MS and BS degrees in the Industrial and Systems Engineering department at Lehigh University.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach. For the Zoom link and password and to be added to the weekly e-mail for the series, please RSVP. For additional questions, contact CHEPSseminar@umich.edu. Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Wed, 21 Oct 2020 17:19:55 -0400 2020-10-26T16:30:00-04:00 2020-10-26T17:30:00-04:00 Off Campus Location Center for Healthcare Engineering & Patient Safety (CHEPS) Lecture / Discussion Jackie Griffin, Ph.D.
Human Capital, History, Demography & Development (H2D2): Black Economic Progress in the Jim Crow South: Evidence from Rosenwald Schools (October 27, 2020 11:30am) https://events.umich.edu/event/78911 78911-20152765@events.umich.edu Event Begins: Tuesday, October 27, 2020 11:30am
Location: Off Campus Location
Organized By: Department of Economics

To join the seminar, please visit the following webpage.
https://sites.google.com/view/h2d2/seminars

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Workshop / Seminar Mon, 26 Oct 2020 11:56:07 -0400 2020-10-27T11:30:00-04:00 2020-10-27T12:50:00-04:00 Off Campus Location Department of Economics Workshop / Seminar Econ Umich
DCMB / CCMB Seminar (October 28, 2020 4:00pm) https://events.umich.edu/event/78528 78528-20058229@events.umich.edu Event Begins: Wednesday, October 28, 2020 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract: Single-cell RNA sequencing (scRNA-seq) allows researchers to examine the transcriptome at the single-cell resolution and has been increasingly employed as technologies continue to advance. Due to technical and biological reasons unique to scRNA-seq data, clustering and batch effect correction are almost indispensable to ensure valid and powerful data analysis. Multiple methods have been proposed for these two important tasks. For clustering, we have found that different methods, including state-of-the-art methods such as Seurat, SC3, CIDR, SIMLR, t-SNE + k-means, yield varying results in terms of both the number of clusters and actual cluster assignments. We have developed ensemble methods, SAFE-clustering and SAME-clustering, that leverages hyper-graph partitioning algorithms and a mixture model-based approach respectively to produce more robust and accurate ensemble solution on top of clustering results from individual methods. For batch effect correction, we have developed methods based on supervised mutual nearest neighbor detection to harness the power of known cell type labels for certain single cells. We benchmarked all methods in various scRNA-seq datasets to demonstrate their utilities.

Short bio: Yun Li, PhD is an Associate professor of Genetics and Biostatistics at the University of North Carolina, Chapel Hill. Dr. Li is a statistical geneticist with extensive experiences with method development and application on genotype imputation (developer of MaCH and MaCH-admix), genetic studies of recently admixed population, design and analysis of sequencing-based studies, analyses of multi-omics data including mRNA expression, DNA methylation and chromatin three dimensional organization. Dr. Li has been playing an active role in genetic studies of complex human traits resulting many GWAS and meta-analysis publications, including >30 in Nature, Science, Cell, and Nature Genetics. Dr. Li has been leading multiple R01 projects on statistical method development for complex trait genetics. Dr. Li has also been the Director for the Data Science Core of IDDRC (Intellectual and Developmental Disabilities Research Center). Dr. Li has received many awards and became the Thomson Reuters Highly Cited Researcher due to her high impact scientific work. Specifically, her work has been cited >60,000 times with h-index of 64 and i10-index of 113.

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Wed, 14 Oct 2020 10:41:20 -0400 2020-10-28T16:00:00-04:00 2020-10-28T17:00:00-04:00 Off Campus Location DCMB Seminar Series Livestream / Virtual Yun Li, PhD (Associate Professor of Genetics & Biostatistics; Adjunct Associate Professor, Applied Physical Sciences at School of Medicine, Genetics at University of North Carolina)
BME Seminar Series: Sudin Bhattacharya (October 29, 2020 4:00pm) https://events.umich.edu/event/75908 75908-19623826@events.umich.edu Event Begins: Thursday, October 29, 2020 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Join us for our virtual seminar series on Thursdays from 4-5pm!
These events will take place on BlueJeans at this link: https://bluejeans.com/628109990

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Workshop / Seminar Thu, 20 Aug 2020 14:09:37 -0400 2020-10-29T16:00:00-04:00 2020-10-29T17:00:00-04:00 Off Campus Location Biomedical Engineering Workshop / Seminar BME
Biophysics Seminar Series (October 30, 2020 12:00pm) https://events.umich.edu/event/77919 77919-19941584@events.umich.edu Event Begins: Friday, October 30, 2020 12:00pm
Location: Off Campus Location
Organized By: LSA Biophysics

Join us on Zoom: https://umich.zoom.us/j/91037518250

The Biophysics Virtual Seminar Series presents:

Dr. Ido Golding - Professor of Physics, School of Molecular & Cellular Biology, University of Illinois Urbana-Champaign

"Illuminating bacterial individuality"

ABSTRACT: Single-cell measurements of mRNA copy numbers inform our understanding of stochastic gene expression, but these measurements coarse-grain over the individual copies of the gene, where transcription and its regulation take place stochastically. We recently combined single-molecule quantification of mRNA and gene loci to measure the transcriptional activity of an endogenous gene in
individual Escherichia coli bacteria. When interpreted using a theoretical model for mRNA dynamics, the single-cell data allowed us to obtain the probabilistic rates of promoter switching, transcription initiation and elongation, mRNA release and degradation. Unexpectedly, we found that gene activity can be strongly coupled to the transcriptional state of another copy of the same gene present in the cell, and to the event of gene replication during the bacterial cell cycle. These gene-copy and cell-cycle correlations demonstrate the limits of mapping whole-cell mRNA numbers to the underlying stochastic gene activity and highlight the contribution of previously hidden variables to the observed population heterogeneity.

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Livestream / Virtual Mon, 26 Oct 2020 09:26:15 -0400 2020-10-30T12:00:00-04:00 2020-10-30T13:00:00-04:00 Off Campus Location LSA Biophysics Livestream / Virtual Dr. Ido Golding
Economics at Work (October 30, 2020 1:00pm) https://events.umich.edu/event/78078 78078-19957577@events.umich.edu Event Begins: Friday, October 30, 2020 1:00pm
Location: Off Campus Location
Organized By: Department of Economics

Economics@Work is intended for any student who is interested in learning about a variety of career opportunities for economics majors. Early students of economics may use this class to explore whether an economics major best suits their interests and goals. Advanced students in economics will benefit from the information and networking opportunities.

To join the seminar, please register from the following link.
https://forms.gle/nCQSPmbG9in5xSoN8

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Workshop / Seminar Thu, 01 Oct 2020 17:22:28 -0400 2020-10-30T13:00:00-04:00 2020-10-30T14:30:00-04:00 Off Campus Location Department of Economics Workshop / Seminar Econ Umich
Rightsizing Prenatal Care: Tailoring Prenatal Services to Match Patients’ Needs (November 2, 2020 5:30pm) https://events.umich.edu/event/78743 78743-20115267@events.umich.edu Event Begins: Monday, November 2, 2020 5:30pm
Location: Off Campus Location
Organized By: Center for Healthcare Engineering & Patient Safety (CHEPS)

Please note the seminar starts at 5:30 PM EST, an hour later than our usual seminar time.

Each year, nearly 4 million women who give birth in the United States receive prenatal care—a crucial preventive service that improves pregnancy outcomes for mothers and their children. National guidelines currently recommend 12 to 14 in-person prenatal visits for all patients regardless of medical or social needs. This schedule recommends more care for low-risk women than peer countries with better outcomes that the U.S., and has remained unchanged since 1930, failing to adapt to the needs of modern patients. Current prenatal care has also failed to address significant inequities in maternity care: low-income and black patients less likely to receive recommended services before delivery, and are more likely to suffer from severe maternal morbidity and mortality in pregnancy.

Although we know that prenatal care services (e.g. laboratory tests and vaccinations) are evidence based, these evidence-based services can be delivered in fewer than 14 visits. There is also evidence that patients do not need to visit clinics in person to receive all maternity services. This schedule results in overutilization of care for low-risk pregnant patients, and potential access issues for patients with more intense needs in pregnancy. In this talk, we will review the evidence supporting prenatal care and new delivery models. We will then introduce a new conceptual model for redesigning prenatal care to meet patients’ diverse medical and social needs, and demonstrate how this model can be used to test new models of prenatal care to drive appropriate resource allocation. We will conclude with early findings from new models that were launched during the COVID-19 pandemic with a focus on ensuring new prenatal care delivery is effective, efficient and equitable.

Dr. Alex Peahl is an Obstetrician Gynecologist and physician-investigator in the Department of Obstetrics and Gynecology at the University of Michigan. Her research focuses on how to improve the effectiveness, efficiency and equity of reproductive health care through developing, studying and disseminating high-quality maternity care interventions. She is a nationally recognized expert on prenatal care redesign and innovation and has completed seminal studies and thought pieces on how to best incorporate patients’ preferences and needs into rightsized prenatal care plans: plans that match patients’ needs to services delivered. She is the research lead for prenatal care redesign at the University of Michigan, and new guidelines driven by her team were recognized by the American College of Obstetricians and Gynecologists as the example for nationwide practice during the COVID-19 pandemic. She is currently leading the Michigan Plan for Appropriate, Tailored Healthcare in Pregnancy, a national consensus process to develop new prenatal care guidelines in pregnancy.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach. For the Zoom link and password and to be added to the weekly e-mail for the series, please RSVP. For additional questions, contact CHEPSseminar@umich.edu. Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Wed, 21 Oct 2020 17:28:03 -0400 2020-11-02T17:30:00-05:00 2020-11-02T18:30:00-05:00 Off Campus Location Center for Healthcare Engineering & Patient Safety (CHEPS) Lecture / Discussion Alex Peahl, MD, MSc
Human Capital, History, Demography & Development (H2D2): Demand Shocks, Staffing Decisions, and Firm Performance: Evidence from the Introduction of a Food Delivery Platform in Colombia (November 3, 2020 11:30am) https://events.umich.edu/event/78920 78920-20154730@events.umich.edu Event Begins: Tuesday, November 3, 2020 11:30am
Location: Off Campus Location
Organized By: Department of Economics

To join the seminar, please visit the following webpage.
https://sites.google.com/view/h2d2/seminars

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Workshop / Seminar Mon, 26 Oct 2020 13:59:09 -0400 2020-11-03T11:30:00-05:00 2020-11-03T12:50:00-05:00 Off Campus Location Department of Economics Workshop / Seminar Econ Umich
MIPSE Seminar | Quantum Hydrodynamics and Rayleigh-Taylor Instability (November 4, 2020 3:30pm) https://events.umich.edu/event/76466 76466-19717159@events.umich.edu Event Begins: Wednesday, November 4, 2020 3:30pm
Location: Off Campus Location
Organized By: Michigan Institute for Plasma Science and Engineering (MIPSE)

The seminar is free and open to the public.
To request the Zoom link, please send an email to:
mipse-central@umich.edu

Abstract:
Matter at extreme pressures, temperatures, and densities characterizes a wide variety of natural and man-made phenomena, including interiors of Jovian size planets, hyper-velocity meteor impacts, the burning core of stars, thermonuclear burning inertial confinement fusion capsules. Matter at these conditions defines the exciting and challenging field of High Energy Density Physics (HEDP). Besides vast experimental resources, there exists a rich set of computational tools that model the micro to macro regimes of HEDP. Recently, there has been a resurgence in interest in using a “simpler” approach to investigating HEDP based on quantum hydrodynamics. Quantum Hydrodynamics (QHD) has a long and interesting history, dating back to the first developments by Madelung and Bohm. In this talk, we discuss the historical and recent developments in QHD, including pitfalls, as applied to quantum many-body systems relevant to HEDP regimes. We will present three different approaches to deriving the QHD equations-Madelung, Bloch, and Wigner and discuss their pros and cons. Finally, the role that Rayleigh-Taylor hydrodynamic instabilities play is discussed within the QHD formalism.

About the Speaker:
Frank Graziani received a BS in physics from Santa Clara U., and a PhD in physics from UCLA. He was a postdoctoral fellow at U. Colorado and U. Minnesota working in cosmology and particle physics; and worked with NASA on exoplanet dynamics and star formation. Dr. Graziani joined Lawrence Livermore National Lab. in 1989 where he worked in radiation transport and plasma physics. He has held many leadership positions at LLNL, including group leader, V&V Leader, PI for LDRD-Strategic Initiatives, lead for the National Boost Initiative and Assoc. Division Leader for computational physics. He now directs the High Energy Density Sciences Center. He has won four DOE Defense Program Awards of Excellence, the LLNL Director’s S&T Award and is a Distinguished Member of the Technical Staff. His research interests include the micro-physics of dense plasmas and HED education. Dr. Graziani is editor of two books on computational methods and a book on warm dense matter physics.

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Livestream / Virtual Tue, 01 Sep 2020 10:59:54 -0400 2020-11-04T15:30:00-05:00 2020-11-04T16:30:00-05:00 Off Campus Location Michigan Institute for Plasma Science and Engineering (MIPSE) Livestream / Virtual Dr. Frank Graziani
DCMB / CCMB Weekly Seminar (November 4, 2020 4:00pm) https://events.umich.edu/event/78770 78770-20121164@events.umich.edu Event Begins: Wednesday, November 4, 2020 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract: Metabolomics is a powerful approach to characterize small molecules produced in cells, tissues, and other biological systems. Metabolites are direct products of enzymatic reactions and provide a snapshot of cellular activities. Metabolomics-based research has already had a profound impact on biomarker discovery, nutritional analysis, and other biomedical and biological discoveries. The most pressing problem in metabolomics however is identifying compounds in the sample-under-study from the metabolomics measurements. Current analysis tools are capable of annotating only a small portion of sample measurements.

In this talk, we present machine learning solutions to three challenges related to the interpretation of metabolomics data. To mimic the function of a mass spectrometer in generating a mass spectrum, we use graph neural networks to translate a molecular structure into its respective spectral signature. To interpret the biological measurements in the context of the biological sample, we use Bayesan learning to deduce the likelihood of pathway activities. To suggest putative candidate molecules that are biologically relevant matches to the measured spectra, we explore several methods for predicting possible enzymatic products. We discuss several results, highlighting the value of using machine learning for advancing metabolomics analysis.

Short bio: Soha Hassoun is Professor and Past Chair of the Department of Computer Science at Tufts University. Soha received her undergraduate degree in Electrical Engineering from South Dakota State University, the Master's degree from MIT, and the Ph.D. degree from the Department of Computer Science and Engineering, University of Washington in Seattle. Soha’s lab uses Machine Learning to develop analysis and discovery tools for synthetic and systems biology, with a focus on enzyme promiscuity prediction and metabolomics analysis. Soha was a recipient of the NSF CAREER Award, and several technical and service awards from various professional societies. She provided technical leadership for several conferences including ICCAD and DAC. She co-founded the International Workshop on Bio-Design Automation in 2009. Soha serves on the board of the Computing Research Association's Committee on Widening Participation in Computing Research.

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Thu, 22 Oct 2020 11:33:23 -0400 2020-11-04T16:00:00-05:00 2020-11-04T17:00:00-05:00 Off Campus Location DCMB Seminar Series Livestream / Virtual
Michael Beauregard Seminar in Macroeconomics (November 4, 2020 4:00pm) https://events.umich.edu/event/79058 79058-20184340@events.umich.edu Event Begins: Wednesday, November 4, 2020 4:00pm
Location: Off Campus Location
Organized By: Department of Economics

Abstract:
Details to Come.

* To join the seminar, please contact at econ.events@umich.edu

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Other Fri, 30 Oct 2020 09:22:57 -0400 2020-11-04T16:00:00-05:00 2020-11-04T17:00:00-05:00 Off Campus Location Department of Economics Other Econ Umich
BME Seminar Series: Lori Setton (November 5, 2020 4:00pm) https://events.umich.edu/event/75909 75909-19623827@events.umich.edu Event Begins: Thursday, November 5, 2020 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Join us for our virtual seminar series on Thursdays from 4-5pm!
These events will take place on BlueJeans at this link: https://bluejeans.com/628109990

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Workshop / Seminar Thu, 20 Aug 2020 14:14:30 -0400 2020-11-05T16:00:00-05:00 2020-11-05T17:00:00-05:00 Off Campus Location Biomedical Engineering Workshop / Seminar BME
Biophysics Seminar Series (November 6, 2020 12:00pm) https://events.umich.edu/event/77920 77920-19941585@events.umich.edu Event Begins: Friday, November 6, 2020 12:00pm
Location: Off Campus Location
Organized By: LSA Biophysics

The Biophysics Virtual Seminar Series presents:

Dr. Nozomi Ando - Assistant Professor of Chemistry & Chemical Biology, Cornell University

*"Protein Allostery: Evolution and Correlated Motions"*

Join us on Zoom: https://umich.zoom.us/j/99976448506

ABSTRACT: Understanding the relationship between protein sequence, structure, dynamics, and function is the ultimate goal of structural biology. For this reason, my lab studies protein allostery - a special property of macromolecules that connects molecular motion and action. In this talk, I'll present two stories. First, I'll talk about how the evolution of allosteric mechanisms and the tools of structural biology can teach us about the relationship between protein sequence and function. In the second story, I'll talk about how one can learn about correlated motions that give rise to allostery.

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Livestream / Virtual Mon, 02 Nov 2020 09:56:44 -0500 2020-11-06T12:00:00-05:00 2020-11-06T13:00:00-05:00 Off Campus Location LSA Biophysics Livestream / Virtual Dr. Nozomi Ando
MCDB Virtual: Olfactory Navigation in Drosophila--Algorithms and Circuits (November 6, 2020 12:00pm) https://events.umich.edu/event/77405 77405-19848067@events.umich.edu Event Begins: Friday, November 6, 2020 12:00pm
Location: Off Campus Location
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Josie Clowney

Abstract: Olfactory navigation provides a tractable model for studying the circuit basis of sensori-motor transformations and goal-directed behavior. Macroscopic organisms typically navigate in odor plumes that provide a noisy and uncertain signal about the location of an odor source. Work in many species has suggested that animals accomplish this task by combining temporal processing of dynamic odor information with an estimate of wind direction.

Our lab has been using adult walking Drosophila to understand both the computational algorithms and the neural circuits that support navigation in a plume of attractive food odor. We developed a high-throughput paradigm to study behavioral responses to temporally-controlled odor and wind stimuli. Using this paradigm we found that flies respond to a food odor (apple cider vinegar) with two behaviors: during the odor they run upwind, while after odor loss they perform a local search. A simple computational model based one these two responses is sufficient to replicate many aspects of fly behavior in a natural turbulent plume.

In on-going work, we are seeking to identify the neural circuits and biophysical mechanisms that perform the computations delineated by our model. Using electrophysiology, we have identified mechanosensory neurons that compute wind direction from movements of the two antennae, and central mechanosensory neurons that encode wind direction are involved in generating a stable downwind orientation. Using optogenetic activation, we have traced olfactory circuits capable of evoking upwind orientation and offset search from the periphery, through the mushroom body and lateral horn, to the central complex. Most recently, connectomic analysis has suggested a plausible model for how wind and odor information might be integrated in the central complex to allow flies to flexibly alter their orientation to wind. Our work illustrates how the tools available in fruit fly can be applied to dissect the mechanisms underlying a complex goal-directed behavior.

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Workshop / Seminar Mon, 26 Oct 2020 15:53:06 -0400 2020-11-06T12:00:00-05:00 2020-11-06T13:00:00-05:00 Off Campus Location Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Katherine Nagel with lab view behind her
Economics at Work (November 6, 2020 1:00pm) https://events.umich.edu/event/78079 78079-19957578@events.umich.edu Event Begins: Friday, November 6, 2020 1:00pm
Location: Off Campus Location
Organized By: Department of Economics

Economics@Work is intended for any student who is interested in learning about a variety of career opportunities for economics majors. Early students of economics may use this class to explore whether an economics major best suits their interests and goals. Advanced students in economics will benefit from the information and networking opportunities.

To join the seminar, please register from the following link.
https://forms.gle/QYre9DYYtmq8Wpe89

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Workshop / Seminar Thu, 01 Oct 2020 17:25:52 -0400 2020-11-06T13:00:00-05:00 2020-11-06T14:30:00-05:00 Off Campus Location Department of Economics Workshop / Seminar Econ Umich
Economic Theory: Persuading Statisticians (November 6, 2020 2:30pm) https://events.umich.edu/event/81680 81680-20941464@events.umich.edu Event Begins: Friday, November 6, 2020 2:30pm
Location: Off Campus Location
Organized By: Department of Economics

Abstract:
A decision maker (DM) contemplates whether to take a costly action. The DM does not know the action's value and relies on data and unbiased statistical inference to estimate it. The data are Bernoulli experiments governed by the action's value. A designer, who wishes the DM to take the action, controls the size of the data, i.e., the sample size, available to the DM. We establish that in many environments the designer's optimal sample size is the largest one satisfying that either a single --- or a simple majority --- of favorable realizations would persuade the DM to take the action.

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Workshop / Seminar Wed, 03 Feb 2021 11:53:54 -0500 2020-11-06T14:30:00-05:00 2020-11-06T15:50:00-05:00 Off Campus Location Department of Economics Workshop / Seminar Econ Umich
Social, Behavioral & Experimental Economics (SBEE): Disguising Prejudice: Popular Rationales as Excuses for Intolerant Expression (November 10, 2020 10:00am) https://events.umich.edu/event/79006 79006-20170600@events.umich.edu Event Begins: Tuesday, November 10, 2020 10:00am
Location: Off Campus Location
Organized By: Department of Economics

Abstract:
We study the use of popular rationales to justify public anti-minority actions. Rationales to oppose minorities change some people's private opinions, leading them to take anti-minority actions even if they are not prejudiced against minorities. When these rationales become widespread, prejudiced people can pool with unprejudiced people who are persuaded, decreasing the stigma associated with anti-minority expression and enabling greater public opposition to minority groups. In a first experiment, subjects learn that a previous respondent authorized a donation to an anti-immigrant organization and then make an inference about the respondent's underlying motivations. Subjects informed that their matched respondent learned about a study claiming that immigrants increase crime rates before authorizing the donation see the respondent as less intolerant and more easily persuadable. In a second experiment, subjects learn about that same study and then choose whether to authorize a publicly observable donation to the anti-immigrant organization. Subjects who are informed that their exposure to the rationale will be publicly observable are substantially more likely to make the donation than subjects who believe that their exposure will remain anonymous. Our findings suggest that prominent public figures can lower the social cost of intolerant expression by popularizing rationales, contributing to waves of anti-minority behavior.

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Workshop / Seminar Wed, 28 Oct 2020 15:23:25 -0400 2020-11-10T10:00:00-05:00 2020-11-10T11:15:00-05:00 Off Campus Location Department of Economics Workshop / Seminar Econ Umich
Students’ mobility patterns on campus and the implications for the recovery of campus activities post-pandemic (November 10, 2020 10:30am) https://events.umich.edu/event/79204 79204-20231445@events.umich.edu Event Begins: Tuesday, November 10, 2020 10:30am
Location: Off Campus Location
Organized By: Michigan Institute for Data Science

This research project uses location data gathered from WiFi access points on campus to model the mobility patterns of students in order to inform the planning of educational activities that can minimize the transmission risk.
The first aim is to understand the general mobility patterns of students on campus to identify physical spaces associating with a high-risk of transmission. For example, we can extract insights from WiFi data about which locations are the busiest during which time of the day, how much time was typically spent at each location, and how do these mobility patterns change over time. The second aim is to understand how students share the same physical spaces on campus (e.g. attending a lecture, meeting in the same room, sharing the same dorm). Students are presumably in a close proximity when they are connected to the same WiFi access point. We model a student-to-student network from their co-location activities and use its network centrality measures as proxies of transmission risk (i.e. students in the center of a network would have a higher chance of getting exposed to COVID-19 than those in the periphery). We then correlate network centrality measures with academic information (e.g. class schedule, course enrollment, study major, year of study, gender, ethnicity) to determine whether certain features of the academic record are related to transmission risk. For example, we can identify which groups of students are more vulnerable to potential infections by associating with a high network centrality. Insights from this research project will inform the University of Michigan’s strategies for the recovery of educational activities post-pandemic with empirical evidence of students’ mobility pattern on campus as well as factors that associate with a high-risk of transmission.

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Presentation Thu, 05 Nov 2020 09:35:37 -0500 2020-11-10T10:30:00-05:00 2020-11-10T10:50:00-05:00 Off Campus Location Michigan Institute for Data Science Presentation Quan Nguyen
Human Capital, History, Demography & Development (H2D2): Legacies of Colonial Rule and the HIV Epidemic in Africa: Evidence from the Mozambique Company Concession (November 10, 2020 11:30am) https://events.umich.edu/event/78921 78921-20154731@events.umich.edu Event Begins: Tuesday, November 10, 2020 11:30am
Location: Off Campus Location
Organized By: Department of Economics

To join the seminar, please visit the following webpage.
https://sites.google.com/view/h2d2/seminars

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Workshop / Seminar Mon, 26 Oct 2020 14:02:42 -0400 2020-11-10T11:30:00-05:00 2020-11-10T12:50:00-05:00 Off Campus Location Department of Economics Workshop / Seminar Econ Umich
Of Moms and Microbes: Pregnancy and the Microbiome (November 10, 2020 12:00pm) https://events.umich.edu/event/79039 79039-20178452@events.umich.edu Event Begins: Tuesday, November 10, 2020 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Kimberly McKee, PhD, Assistant Professor of Family Medicine at the UM Medical School will present a seminar, with Q&A, on "Of Moms and Microbes: Pregnancy and the Microbiome".

ZOOM link:
https://umich.zoom.us/j/97328685723

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Lecture / Discussion Thu, 29 Oct 2020 13:13:13 -0400 2020-11-10T12:00:00-05:00 2020-11-10T12:50:00-05:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Environmental Research Seminar
DCMB / CCMB Weekly Seminar (November 11, 2020 4:00pm) https://events.umich.edu/event/79286 79286-20264787@events.umich.edu Event Begins: Wednesday, November 11, 2020 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract: There is a growing understanding that stress and depression during the process of training to become physicians is high. In this talk, we will discuss how we have used mobile and wearable data as well as genomics to understand the prevalence in the US and China, drivers and possible solutions about training physician depression and how the COVID-19 pandemic has affected them in the two countries.

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Mon, 09 Nov 2020 14:13:58 -0500 2020-11-11T16:00:00-05:00 2020-11-11T17:00:00-05:00 Off Campus Location DCMB Seminar Series Livestream / Virtual Drs. Margit Burmeister and Srijan Sen
Michael Beauregard Seminar in Macroeconomics: Scalable Expertise (November 11, 2020 4:00pm) https://events.umich.edu/event/79059 79059-20184343@events.umich.edu Event Begins: Wednesday, November 11, 2020 4:00pm
Location: Off Campus Location
Organized By: Department of Economics

Abstract:
We document that aggregate or sectoral demand shocks have disproportionately bigger effects on larger firms. Changes in scope, the number of products/locations, plays a significant role in this heterogeneity. Motivated by these facts, we present a theory of firm size, where both scope and expertise (which determines revenues and profits) are chosen endogenously. The extent to which expertise is scalable (applicable to multiple products), as opposed to local (specific to a particular product), is also chosen by the firm. The model predicts rich heterogeneity in responses to a sector-wide demand shock: firms with higher revenue per product (conditional on scope) adjust their scope by less, while those with higher scope (conditional on revenue per peroduct) adjust by more. Using data on multi-product and multi-establishment firms, we provide empirical evidence in support of these predictions. We also construct a proxy for the scalability of the firm’s expertise and show that the predictions of the model with respect to the scalability of firm-level expertise, both in the cross-section and in response to shocks, are also consistent with the patterns observed in the data.

* To join the seminar, please contact at econ.events@umich.edu

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Workshop / Seminar Mon, 09 Nov 2020 17:22:03 -0500 2020-11-11T16:00:00-05:00 2020-11-11T17:00:00-05:00 Off Campus Location Department of Economics Workshop / Seminar Econ Umich
A New Perspective on Amelogenesis and Dental Diagnoses (November 12, 2020 12:00pm) https://events.umich.edu/event/79191 79191-20225570@events.umich.edu Event Begins: Thursday, November 12, 2020 12:00pm
Location: Off Campus Location
Organized By: Office of Research School of Dentistry

James P. Simmer, DDS, PhD Professor of Dentistry
Biologic and Materials Sciences & Prosthodontics
University of Michigan School of Dentistry

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Lecture / Discussion Wed, 04 Nov 2020 15:24:08 -0500 2020-11-12T12:00:00-05:00 2020-11-12T13:00:00-05:00 Off Campus Location Office of Research School of Dentistry Lecture / Discussion Simmer
BME Seminar Series: Eytan Ruppin (November 12, 2020 4:00pm) https://events.umich.edu/event/75910 75910-19623828@events.umich.edu Event Begins: Thursday, November 12, 2020 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Join us for our virtual seminar series on Thursdays from 4-5pm!
These events will take place on BlueJeans at this link: https://bluejeans.com/628109990

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Workshop / Seminar Thu, 20 Aug 2020 14:22:54 -0400 2020-11-12T16:00:00-05:00 2020-11-12T17:00:00-05:00 Off Campus Location Biomedical Engineering Workshop / Seminar BME
Michael Woodroofe Lecture Series: Emery Brown, Director of the Harvard–MIT Program of Health Sciences and Technology (November 13, 2020 10:00am) https://events.umich.edu/event/76734 76734-19741053@events.umich.edu Event Begins: Friday, November 13, 2020 10:00am
Location: Off Campus Location
Organized By: Department of Statistics

Abstract: General anesthesia is a drug-induced, reversible condition comprised of five behavioral states: unconsciousness, amnesia (loss of memory), antinociception (loss of pain sensation), akinesia (immobility), and hemodynamic stability with control of the stress response. Our work shows that a primary mechanism through which anesthetics create these altered states of arousal is by initiating and maintaining highly structured oscillations. These oscillations impair communication among brain regions. We illustrate this effect by presenting findings from our human studies of general anesthesia using high-density EEG recordings and intracranial recordings. These studies have allowed us to give a detailed characterization of the neurophysiology of loss and recovery of consciousness due to propofol. We show how these dynamics change systematically with different anesthetic classes and with age. We have developed a principled, neuroscience-based paradigm for using the EEG to monitor the brain states of patients receiving general anesthesia. We demonstrate that the state of general anesthesia can be rapidly reversed by activating specific brain circuits. Finally, we demonstrate that the state of general anesthesia can be controlled using closed loop feedback control systems. The success of our research has depended critically on tight coupling of experiments, signal processing research and mathematical modeling.

Biography: Emery N. Brown, M.D., Ph.D. is the Warren M. Zapol Professor of Anaesthesia at Harvard Medical School; an anesthesiologist at Massachusetts General Hospital; and the Edward Hood Taplin Professor of Medical Engineering and Computational Neuroscience at MIT. Brown is an anesthesiologist-statistician whose research is defining the neuroscience of how anesthetics produce general anesthesia. He also develops statistical methods for neuroscience data analysis. Dr. Brown has received the American Society of Anesthesiologists Excellence in Research Award and the Dickson Prize in Science and the Swartz Prize for Computational and Theoretical Neuroscience. He is a fellow of the American Academy of Arts Sciences and the National Academy of Inventors. Dr. Brown is a member of the National Academy of Medicine, National Academy of Sciences and the National Academy of Engineering.

This seminar will be livestreamed via Zoom https://umich.zoom.us/j/94350208889
There will be a virtual reception to follow.

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Workshop / Seminar Tue, 10 Nov 2020 14:47:46 -0500 2020-11-13T10:00:00-05:00 2020-11-13T11:00:00-05:00 Off Campus Location Department of Statistics Workshop / Seminar Emery Brown
Biophysics Seminar Series (November 13, 2020 12:00pm) https://events.umich.edu/event/77921 77921-19941586@events.umich.edu Event Begins: Friday, November 13, 2020 12:00pm
Location: Off Campus Location
Organized By: LSA Biophysics

The Biophysics Virtual Seminar Series presents:

Dr. Nancy Forde - Department of Physics, Simon Fraser University

*“Collagen: a fascinating responsive material building block from Nature”*

Join us on Zoom: https://umich.zoom.us/j/96009492561

Abstract: Multicellular life is scaffolded by structures that maintain cells in the desired locations and organizations. Conventionally these extracellular scaffolds have been viewed as rigid, unchanging supports laid down during development and unaltered except by injury or disease. Recent scientific advances are revealing instead that these matrices are highly dynamic and respond to changes in their local microenvironment, in turn affecting cells. The collagen family of proteins has been selected via evolution as the preferred building block of these extracellular structures.

In this talk, I will introduce some of the fascinating physical properties of the unique triple-helix structure of collagen, and will highlight the results of our investigations into its mechanical properties. Our single-molecule approaches include centrifuge force microscopy, optical tweezers and atomic force microscopy, and many parallels can be drawn with the mechanics of DNA. Our work is revealing clues as to how stability is encoded within collagen’s sequence, and how collagen’s triple helix balances structural stability with responsiveness to applied force and chemical environment.

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Livestream / Virtual Wed, 04 Nov 2020 11:44:26 -0500 2020-11-13T12:00:00-05:00 2020-11-13T13:00:00-05:00 Off Campus Location LSA Biophysics Livestream / Virtual Dr. Nancy Forde
Economics at Work (November 13, 2020 1:00pm) https://events.umich.edu/event/78080 78080-19957579@events.umich.edu Event Begins: Friday, November 13, 2020 1:00pm
Location: Off Campus Location
Organized By: Department of Economics

Economics@Work is intended for any student who is interested in learning about a variety of career opportunities for economics majors. Early students of economics may use this class to explore whether an economics major best suits their interests and goals. Advanced students in economics will benefit from the information and networking opportunities.

To join the seminar, please register from the following link.
https://forms.gle/eLwgQ3wda3DmtZ6eA

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Workshop / Seminar Thu, 01 Oct 2020 17:28:58 -0400 2020-11-13T13:00:00-05:00 2020-11-13T14:30:00-05:00 Off Campus Location Department of Economics Workshop / Seminar Econ Umich
Honors Seminar Series: Ethan Kross (November 13, 2020 2:00pm) https://events.umich.edu/event/76513 76513-19719174@events.umich.edu Event Begins: Friday, November 13, 2020 2:00pm
Location: Off Campus Location
Organized By: LSA Honors Program

On October 8, 2013 Malala Yousafzai appeared on the Daily Show to talk about her harrowing experience surviving the Taliban’s attempt to assassinate her. At one point during the interview she described how she reacted when she discovered that the Taliban were planning to kill her. “I used to think that the Tali[ban] would come and he would just kill me,” she told to Stewart. “But then I said, if he comes, what would you do Malala? Then I would reply to myself, Malala just take a shoe and hit him…”

Malala’s interview provides a window into the at times curious ways that we reflect on our lives. Although we all have an inner monologue that we engage in from time to time, an inner voice that guides our moment-to-moment reflections, people often report referring to themselves in strikingly different ways when they introspect. Whereas people typically use 1st person singular pronouns (e.g., I, me, my) to refer to themselves during introspection, they at times also use their own name and other non-1st-person pronouns to refer to themselves as well.

In this talk, Professor Ethan Kross will review findings from a growing body of psychological and neuroscience research, which suggests that far from representing a simple quirk of speech, engaging in such distanced self-talk enhances people’s ability to control their thoughts, feelings and behavior under stress.

You can register here: https://myumi.ch/0W1Op

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Workshop / Seminar Thu, 29 Oct 2020 09:47:52 -0400 2020-11-13T14:00:00-05:00 2020-11-13T15:00:00-05:00 Off Campus Location LSA Honors Program Workshop / Seminar Professor Ethan Kross
Economic Theory: Caution and Reference Effects (oint with Simone Cerreia-Vioglio and David Dillenberger) (November 13, 2020 2:30pm) https://events.umich.edu/event/81681 81681-20941465@events.umich.edu Event Begins: Friday, November 13, 2020 2:30pm
Location: Off Campus Location
Organized By: Department of Economics

Abstract:
We establish a theoretical link between three phenomena at the core of behavioral economics: the Endowment Effect, Loss Aversion, and violations of Expected Utility as in the Certainty Effect. In our model, all jointly stem from one single force: uncertainty about the utility function to use and caution. Behaviorally, we show that our model is derived from positing a form of the certainty effect, that we show implies both Loss Aversion and the Endowment Effect. We analyze further implications of our model and demonstrate how it can organize existing empirical evidence of the Endowment Effect, and how it is conceptually and behaviorally distinct from other popular approaches, e.g., Cumulative Prospect Theory.

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Workshop / Seminar Wed, 03 Feb 2021 11:56:40 -0500 2020-11-13T14:30:00-05:00 2020-11-13T15:50:00-05:00 Off Campus Location Department of Economics Workshop / Seminar Econ Umich
Optimal Influenza Vaccine Distribution With Equity (November 16, 2020 4:30pm) https://events.umich.edu/event/79331 79331-20272794@events.umich.edu Event Begins: Monday, November 16, 2020 4:30pm
Location: Off Campus Location
Organized By: Center for Healthcare Engineering & Patient Safety (CHEPS)

Influenza is a serious public health concern. Each year 5-15% of the world’s population is infected with influenza resulting in 3-5 million severe cases and 250,000-500,000 deaths. This presentation is concerned with the optimal influenza vaccine distribution in a heterogeneous population consisting of multiple subgroups. In our experiments, each subgroup corresponds to a set of people within an age group living in a certain geographic area, however the definition of subgroup is flexible. For example, healthcare workers or nursing home residents can be considered as subgroups in real life policy decisions. To characterize the spread of influenza through interacting subgroups, we employ an epidemic model that incorporates transmission dynamics and social distancing. The epidemic model is then coupled with a nonlinear mathematical program to find the critical vaccine allocation that minimizes vaccine usage. We also include an equity constraint to help public health authorities find a balanced vaccine allocation policy with respect to equity and effectiveness. Several detailed epidemic simulation models are developed in the literature to evaluate vaccination policies before their implementation so as to efficiently allocate resources. This study goes beyond evaluating a given vaccine allocation policy. The proposed approach can be utilized as a decision support tool to prescribe an equitable vaccine allocation policy to extinguish an emerging outbreak in its early stages. Furthermore, the optimal objective function value of our model can inform public health authorities about the amount of vaccine stockpiles needed to stop future outbreaks. Our results indicate that consideration of group-specific transmission dynamics is paramount to the optimal distribution of influenza vaccines.

Shakiba Enayati is an Assistant Professor in Supply Chain and Analytics Department in the College of Business Administration at the University of Missouri- Saint Louis. She earned her Ph.D. in Operations Research Program from North Carolina State University in May 2017. She also holds a Master of Science and a Bachelor in Industrial Engineering from Tarbiat Modares University and Iran University of Science and Technology in Tehran, Iran. She was previously employed as Assistant Professor of Analytics in Management, Information Systems, and Analytics Department at State University of New York, Plattsburgh. Shakiba’s primary research interests are in analytical modeling and optimization of stochastic/dynamic complex systems as applied to healthcare and service systems. Her goal is to address computational and operational aspects of problems arising in public health policy making, health systems management, and medical decision making via incorporating individual patient data. She is also interested in predictive analytics to evaluate, anticipate, and recommend actions for health outcomes at both individual and system levels. Her Ph.D. dissertation focused on service quality improvement and optimally allocating resources in the dynamic and stochastic environment of Emergency Medical Service systems under realistic operational restrictions.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach. For the Zoom link and password and to be added to the weekly e-mail for the series, please RSVP. For additional questions, contact CHEPSseminar@umich.edu. Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Tue, 10 Nov 2020 16:00:42 -0500 2020-11-16T16:30:00-05:00 2020-11-16T17:30:00-05:00 Off Campus Location Center for Healthcare Engineering & Patient Safety (CHEPS) Lecture / Discussion Shakiba Enayati, Ph.D.
Human Capital, History, Demography & Development (H2D2): Wage Inequality and the Rise in Labor Force Exit: The Case of US Prime-Age Men (November 17, 2020 11:30am) https://events.umich.edu/event/78922 78922-20154732@events.umich.edu Event Begins: Tuesday, November 17, 2020 11:30am
Location: Off Campus Location
Organized By: Department of Economics

To join the seminar, please visit the following webpage.
https://sites.google.com/view/h2d2/seminars

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Workshop / Seminar Mon, 26 Oct 2020 14:05:47 -0400 2020-11-17T11:30:00-05:00 2020-11-17T12:50:00-05:00 Off Campus Location Department of Economics Workshop / Seminar Econ Umich
Deploying CV2X Infrastructure - CCAT Research Review (November 17, 2020 2:00pm) https://events.umich.edu/event/78766 78766-20121156@events.umich.edu Event Begins: Tuesday, November 17, 2020 2:00pm
Location: Off Campus Location
Organized By: Center for Connected and Automated Transportation

The final CCAT Research Review of 2020 will feature Associate Professor, Gabor Orosz, of the University of Michigan.

The focus of this research is the deployment of connected smart infrastructure on highway I-275 in SE Michigan. Researchers will collect and aggregate traffic information that can be used by connected vehicles traveling the corridor to improve their efficiency. The system consists of a set of road side units (RSU) which collect traffic data via vehicle-to-everything (CV2X) communication. Vehicles of different levels of automation may utilize the collected data when selecting their lane and controlling their longitudinal motion in order to maximize their fuel economy and minimize their travel time. The impact of these vehicles on the rest of the traffic flow is also being evaluated.

About the speaker: Gabor Orosz received the MSc degree in Engineering Physics from the Budapest University of Technology, Hungary, in 2002 and the PhD degree in Engineering Mathematics from the University of Bristol, UK, in 2006. He held postdoctoral positions at the University of Exeter, UK and at the University of California, Santa Barbara. In 2010, he joined the University of Michigan, Ann Arbor where he is currently an Associate Professor in Mechanical Engineering and in Civil and Environmental Engineering. During 2017-2018 he was a Visiting Professor in Control and Dynamical Systems at the California Institute of Technology. His research interests include nonlinear dynamics and control, time delay systems, and reinforcement learning with applications to connected and automated vehicles, traffic flow, and biological networks. He served as the Program Chair of the 2015 IFAC Workshop on Time Delay Systems and served as the General Chair of the 2019 IAVSD Workshop on Dynamics of Road Vehicles: Connected and Automated Vehicles. Since 2018 he has been serving as an editor for the journal Transportation Research Part C.

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Livestream / Virtual Thu, 22 Oct 2020 10:09:41 -0400 2020-11-17T14:00:00-05:00 2020-11-17T15:00:00-05:00 Off Campus Location Center for Connected and Automated Transportation Livestream / Virtual Decorative Image
From Sky Surveys to Cancer: Spatial Data Everywhere (November 18, 2020 3:00pm) https://events.umich.edu/event/78283 78283-20002866@events.umich.edu Event Begins: Wednesday, November 18, 2020 3:00pm
Location: Off Campus Location
Organized By: Michigan Institute for Data Science

The talk describes a 25 year journey leading from the Sloan Digital Sky Survey to a wide range of projects in data science. There are many common threads: the need for extreme interactivity, the need for flexible data aggregation and the commonality of spatial data. The size of data sets have grown almost a million fold, but user expectations for almost instant results has not changed. The talk will describe the gradual evolution of the SciServer, and how new interactive metaphors to interact with hundreds of terabytes of turbulence simulations emerged. We will discuss how machine learning and AI tools are transforming science, from simulations to how large experiments are designed and executed. We will also emphasize that much of these new developments still rely on having unique high value data sets at our fingertips, and how the long term survival of these is entering a critical, endangered phase.

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Presentation Fri, 13 Nov 2020 12:16:36 -0500 2020-11-18T15:00:00-05:00 2020-11-18T17:00:00-05:00 Off Campus Location Michigan Institute for Data Science Presentation https://umich.zoom.us/j/96874360760
MIPSE Seminar | Lasers, Z Pinches, and Nuclear Weapons: The Importance of Plasma Physics to the NNSA (November 18, 2020 3:30pm) https://events.umich.edu/event/76470 76470-19717163@events.umich.edu Event Begins: Wednesday, November 18, 2020 3:30pm
Location: Off Campus Location
Organized By: Michigan Institute for Plasma Science and Engineering (MIPSE)

The seminar is free and open to the public.
To request the Zoom link, please send an email to:
mipse-central@umich.edu

About the Speaker:
Dr. Sarah Nelson, a nuclear and radiochemist, is Deputy Director of the Office of Experimental Science for the NNSA Office of Defense Programs. Sarah earned her BS from U. California Santa Barbara and doctorate from U. California Berkeley studying odd-Z transactinide compound nucleus reactions including the discovery of the new isotope 260Bh. Prior to joining NNSA, Sarah was the Roger Batzel Fellow at Lawrence Livermore National Laboratory in nuclear chemistry diagnostic development for NIF and analysis of nuclear systems for domestic counterterrorism applications, co-discovering 14 new transactinide isotopes. Sarah also was selected as a Christine Mirzayan Science & Technology Policy Fellow of The National Academies in 2012. Prior to NNSA, Sarah was also with Pacific Northwest National Laboratory on assignment with the Defense Threat Reduction Agency. She has received numerous awards including the DTRA/US STRATCOM Center for Combatting Weapons of Mass Destruction Director’s Award, LLNL’s Excellence in Publication Award in Basic Science, and the Gordon Battelle Prize for Scientific Discovery.

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Livestream / Virtual Tue, 01 Sep 2020 11:12:17 -0400 2020-11-18T15:30:00-05:00 2020-11-18T16:30:00-05:00 Off Campus Location Michigan Institute for Plasma Science and Engineering (MIPSE) Livestream / Virtual Dr. Sarah Nelson
DCMB / CCMB Weekly Seminar (November 18, 2020 4:00pm) https://events.umich.edu/event/79290 79290-20264791@events.umich.edu Event Begins: Wednesday, November 18, 2020 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract: Genetic variation affecting gene expression is wide-spread within and among species. This variation reflects the combined actions of mutation introducing new genetic variants and selection eliminating deleterious ones. Comparative studies of gene expression in fruit flies, yeast, plants, and mice have shown that the relative contributions of cis- and trans-acting variants to expression differences change over evolutionary time, indicating that selection has different effects on cis- and trans-regulatory variants. To better understand the reasons for this now widely observed pattern, we have been systematically studying the effects of mutation and selection on expression of the TDH3 gene of the baker’s yeast Saccharomyces cerevisiae. This work has revealed differences between cis- and trans-regulatory mutations in their frequency, effects, and dominance. Differences in pleiotropy are also generally assumed to exist between cis- and trans-regulatory that affect their evolutionary fate, but have been difficult to measure. In this talk, I will discuss how newly arising cis- and trans-regulatory mutations affecting expression of this focal gene are structured within the regulatory network, their pleiotropic effects on expression of all other genes in the genome, and how these pleiotropic effects influence fitness. A computational model of regulatory evolution integrating empirically observed differences in properties of cis- and trans-regulatory mutations will also be presented and discussed.

Patricia Wittkopp received a BS from the University of Michigan, a PhD from the University of Wisconsin, and did postdoctoral work at Cornell University. In 2005, she began a faculty position at the University of Michigan, where she is now the Sally L. Allen Collegiate Professor and Arthur F Thurnau Professor in the Department of Ecology and Evolutionary Biology and the Department of Molecular, Cellular, and Developmental Biology, and is a member of the Center for Computational Medicine and Bioinformatics. Her research investigates the genetic basis of phenotypic evolution, with an emphasis on the evolution of gene expression. She was a Damon Runyon Cancer Research Fellow, an Alfred P Sloan Research Fellow, Guggenheim Fellow, and a recipient of a March of Dimes Starter Scholar Award, the Margaret Dayhoff Mid-Career Award from the Society of Molecular Biology and Evolution, and the Friedrich Wilhelm Bessel Research Award from the Alexander von Humboldt Foundation.

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Mon, 09 Nov 2020 15:12:34 -0500 2020-11-18T16:00:00-05:00 2020-11-18T17:00:00-05:00 Off Campus Location DCMB Seminar Series Livestream / Virtual
Michael Beauregard Seminar in Macroeconomics: Why does capital flow from equal to unequal countries? (November 18, 2020 4:00pm) https://events.umich.edu/event/79060 79060-20184344@events.umich.edu Event Begins: Wednesday, November 18, 2020 4:00pm
Location: Off Campus Location
Organized By: Department of Economics

Abstract:
Capital flows from equal to unequal countries. We document this empirical regularity in a large sample of advanced economies. The capital flows are largely driven by private savings. We propose a theory that can rationalize these findings: more unequal countries endogenously develop deeper financial markets. Households in unequal counties, in turn, borrow more, driving the observed direction of capital flows.

* To join the seminar, please contact at econ.events@umich.edu

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Workshop / Seminar Mon, 16 Nov 2020 12:12:16 -0500 2020-11-18T16:00:00-05:00 2020-11-18T17:00:00-05:00 Off Campus Location Department of Economics Workshop / Seminar Econ Umich
Chemosensory pathways involved in periodontitis and odontogenic pain (November 19, 2020 12:00pm) https://events.umich.edu/event/79190 79190-20225569@events.umich.edu Event Begins: Thursday, November 19, 2020 12:00pm
Location: Off Campus Location
Organized By: Office of Research School of Dentistry

Marco Tizzano, PhD
Assistant Member, Monell Chemical Senses Center
Adjunct Assistant Professor, Basic & Translational Sciences - Penn Dental Medicine

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Lecture / Discussion Wed, 04 Nov 2020 15:19:42 -0500 2020-11-19T12:00:00-05:00 2020-11-19T13:00:00-05:00 Off Campus Location Office of Research School of Dentistry Lecture / Discussion Tizzano
Women + Data Science (November 19, 2020 3:30pm) https://events.umich.edu/event/78621 78621-20075975@events.umich.edu Event Begins: Thursday, November 19, 2020 3:30pm
Location: Off Campus Location
Organized By: Michigan Institute for Data Science

Michigan State University & University of Michigan invite you to their joint monthly webinar & meetup series for Fall 2020! Please register for access to the Zoom link.

Keynote speaker - Maria Chikina
Lightning talk speakers - Anna Yannakopoulos, MSU | Kayla Johnson, MSU | Stephanie Hickey, MSU

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Presentation Fri, 16 Oct 2020 15:47:06 -0400 2020-11-19T15:30:00-05:00 2020-11-19T17:00:00-05:00 Off Campus Location Michigan Institute for Data Science Presentation Women + Data Science
BME Seminar Series: Maciek Antoniewicz (November 19, 2020 4:00pm) https://events.umich.edu/event/75911 75911-19623829@events.umich.edu Event Begins: Thursday, November 19, 2020 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Join us for our virtual seminar series on Thursdays from 4-5pm!
These events will take place on BlueJeans at this link: https://bluejeans.com/628109990

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Workshop / Seminar Thu, 20 Aug 2020 14:25:40 -0400 2020-11-19T16:00:00-05:00 2020-11-19T17:00:00-05:00 Off Campus Location Biomedical Engineering Workshop / Seminar BME
Biophysics Seminar Series (November 20, 2020 12:00pm) https://events.umich.edu/event/77922 77922-20319908@events.umich.edu Event Begins: Friday, November 20, 2020 12:00pm
Location: Off Campus Location
Organized By: LSA Biophysics

The Biophysics Virtual Seminar Series presents:

Dr. Gabriele Varani - Department of Chemistry, University of Washington

*"Small drug-like molecules targeting RNA with nanomolar affinity and cellular activityon"*

Join us on Zoom: https://umich.zoom.us/j/99793210061

ABSTRACT: The ever expanding appreciation of the role of RNA in healthy and disease cellular states has created ever increasing opportunities to redress human disease by targeting RNA with small molecules. However, the chemistry of small molecules targeting RNA remains a challenge. The academic literature has been littered since the mid-1990s with reports of small molecules binding to RNA that, in most cases, did not have the pharmaceutical properties of successful drug candidates and did not bind to RNA potently nor specifically. Screening protein-directed chemical libraries allows the discovery of drug-like molecules that bind to RNA, but success rates are low, typically 1/10,000, and affinity typically in the low to mid-uM range. We have discovered RNA-binding small molecules that obey Lipinski and RO5 rules and bind to RNA potently (low to mid nM) and specifically (discriminate single nucleotide changes). These molecules target RNAs considered 'undruggable' with low nM affinity. Their size (<400 Da), absence of charge, and in vitro pharmacological properties (ADME and in vitro pharmacology) are those of favorable drug candidates. We will illustrate two examples of the application of this chemistry by reporting 10 nM ligands for HIV TAR and 100 nM ligands for pre-miR-21 with specific biochemical and cellular activity against this potent oncogene.

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Livestream / Virtual Mon, 16 Nov 2020 13:13:38 -0500 2020-11-20T12:00:00-05:00 2020-11-20T13:00:00-05:00 Off Campus Location LSA Biophysics Livestream / Virtual Dr. Gabriele Varani
MCDB Virtual Seminar: Building Functional Neurons with Motors & Microtubules (November 20, 2020 12:00pm) https://events.umich.edu/event/77423 77423-19848085@events.umich.edu Event Begins: Friday, November 20, 2020 12:00pm
Location: Off Campus Location
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Morgan DeSantis

Neurons display an amazing diversity of shapes, sizes and activities. Underlying neuron structure and function is the microtubule cytoskeleton. Microtubules can be stable or highly dynamic, undergoing bouts of growth and shrinkage. We have uncovered a novel a-tubulin mutation that regulates microtubule dynamics, potentially through an effect on acetylation on an uncharacterized site in a-tubulin, and differentially affects the morphology of two distinct neuron types.

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Workshop / Seminar Mon, 16 Nov 2020 15:00:39 -0500 2020-11-20T12:00:00-05:00 2020-11-20T13:30:00-05:00 Off Campus Location Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar drawing of microscope and initials on blue background
Economic Theory: Outside Options and Optimal Bargaining Dynamics (November 20, 2020 2:30pm) https://events.umich.edu/event/81682 81682-20941466@events.umich.edu Event Begins: Friday, November 20, 2020 2:30pm
Location: Off Campus Location
Organized By: Department of Economics

Abstract:
We study how to design optimal bargaining strategies in a bargaining model with two players, P and A, when A’s outside option changes over time. We solve for P’s optimal strategy and find a new, but intuitive, set of bargaining dynamics. When A’s outside option increases, A is tempted to cease bargaining, leading P to increase A’s continuation by gradually promising A a larger share of the surplus (decreasing demands) and giving A more time to explore his outside option before being forced to make a decision (decreasing pressure). We explore comparative statics and show that although P ’s value of bargaining is decreasing in A’s outside option, it increases when the expected value of A’s outside option tomorrow rises. We show P’s optimal strategy can be implemented without commitment.

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Workshop / Seminar Wed, 03 Feb 2021 11:59:53 -0500 2020-11-20T14:30:00-05:00 2020-11-20T15:50:00-05:00 Off Campus Location Department of Economics Workshop / Seminar Econ Umich
Impact of COVID-19 on Service Workers: Work Experiences & Concerns of food retail, food services, and hospitality workers (November 24, 2020 12:00pm) https://events.umich.edu/event/79384 79384-20288598@events.umich.edu Event Begins: Tuesday, November 24, 2020 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Marie-Anne Rosemberg is an assistant professor in UM's School of Nursing.
ABSTRACT
Objectives: COVID-19 presents a unique burden specifically for workers in service industries not only because they are disproportionately at risk for contracting the virus but also because of their work-related burdens. We aimed to understand the impact of COVID-19 on these workers.
Methods: This was a mixed-method study with a congruent triangulation design. Participants were recruited through social media. Each interview lasted up to 20 minutes. The survey data included demographic questions along with items from the CAGE and PC-PTSD questionnaires.
Results: Twenty-seven individuals completed audio-recorded phone interviews and 28 completed the survey. Participants were mostly women with an age range between 19 and 65. Participants worked in food retail (n=23), restaurant (n=25), and hospitality (n=7) industries. Length of time on the job ranged from two months to 25 years and 60% of the participants worked full time. Participants reported experiencing symptoms of depression and maladaptive coping. Job insecurity, change of job tasks, and work hours were the most common ways that COVID-19 affected the workers. Themes that emerged about participant’s concerns included being infected and/or unknowingly infecting others, the unknown, isolation, and work and customer demands. Constant changes relating to communication and protection measures were a major source of stress. There was discordance in the perceived level of threat of COVID-19. Most participants reported that their workplace complied with their state’s mandates for protection measures. While others reported lacking basic supplies such as soap, hand sanitizer, and masks.
Conclusions: In addition to their work experiences, COVID-19 has affected service workers at the financial, physical and mental levels. This study has implications of employers, occupational health and safety professionals and policy stakeholders.

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Lecture / Discussion Thu, 12 Nov 2020 16:33:42 -0500 2020-11-24T12:00:00-05:00 2020-11-24T12:50:00-05:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Impact of COVID-19 on Service Workers
An Industrial Engineering-Based Approach to Designing and Evaluating Healthcare Systems to Improve Veteran Access to Care (November 30, 2020 4:30pm) https://events.umich.edu/event/79527 79527-20351367@events.umich.edu Event Begins: Monday, November 30, 2020 4:30pm
Location: Off Campus Location
Organized By: Center for Healthcare Engineering & Patient Safety (CHEPS)

Access to healthcare is a critical public health issue in the United States, especially for veterans. Veterans are older on average than the general U.S. population and are thus at higher risk for chronic disease. Further, veterans report more delays when seeking healthcare. The Veterans Affairs (VA) Healthcare System continuously works to develop policies and technologies that aim to improve veteran access to care. Industrial engineering methods can be effective in analyzing the impact of such policies, as well as designing or modifying systems to better align veteran patients’ needs with providers and resources.

In the talk, I will focus on veteran access to chronic eye disease screening. Ophthalmologists in the VA have developed a platform in which ophthalmic technicians screen patients for major chronic eye diseases during primary care visits. We use mixed-integer programming-based facility location models to understand how the VA can determine which clinics should offer eye screenings, which provider type(s) should staff those clinics, and how to distribute patients among clinics. The results of this work show how the VA can achieve various objectives including minimizing the cost of treating a given population or maximizing the number of patients receiving care given a fixed budget.

Adam VanDeusen is a PhD candidate in Industrial and Operations Engineering at the University of Michigan working under Dr. Amy Cohn. His work applies operations research and systems engineering methods to public health policy and access to healthcare. As part of his graduate training, Adam works with the University of Michigan Center for Healthcare Engineering & Patient Safety (CHEPS). Adam completed his undergraduate degree in Industrial and Operations Engineering at the University of Michigan and his Master of Public Health in Chronic Disease Epidemiology from Yale School of Public Health. Prior to beginning his PhD, Adam worked as the Senior Director of Clinical Programs at the Health Management Academy and as a Health Systems Engineer at Mayo Clinic.

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach. For the Zoom link and password and to be added to the weekly e-mail for the series, please RSVP. For additional questions, contact CHEPSseminar@umich.edu. Photographs and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Fri, 20 Nov 2020 15:23:50 -0500 2020-11-30T16:30:00-05:00 2020-11-30T17:30:00-05:00 Off Campus Location Center for Healthcare Engineering & Patient Safety (CHEPS) Lecture / Discussion Adam VanDeusen
Social, Behavioral & Experimental Economics (SBEE): Loss Attitudes in the U.S. Population: Evidence from Dynamically Optimized Sequential Experimentation (DOSE) (December 1, 2020 10:00am) https://events.umich.edu/event/78715 78715-20107423@events.umich.edu Event Begins: Tuesday, December 1, 2020 10:00am
Location: Off Campus Location
Organized By: Department of Economics

Abstract:
To measure individual-level loss aversion in a representative sample of the U.S. population (N = 2,000), we introduce DOSE—Dynamically Optimized Sequential Experimentation. We find that around 50% of the U.S. population is loss tolerant. This is
counter to earlier findings, which mostly come from lab/student samples, that a strong majority of participants are loss averse. Loss attitudes are correlated with cognitive ability: loss aversion is more prevalent in people with high cognitive ability, and loss tolerance is more common in those with low cognitive ability. We also use DOSE to document facts about risk and time preferences, and demonstrate that DOSE elicitations are more accurate, more stable across time, and faster to administer than standard methods.

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Workshop / Seminar Tue, 20 Oct 2020 17:29:10 -0400 2020-12-01T10:00:00-05:00 2020-12-01T11:15:00-05:00 Off Campus Location Department of Economics Workshop / Seminar Econ Umich
CSCS Seminar | Developing a systematic approach to modulate the emergence of consciousness from pharmacologically-and pathologically induced unconsciousness (December 1, 2020 11:30am) https://events.umich.edu/event/76220 76220-19677552@events.umich.edu Event Begins: Tuesday, December 1, 2020 11:30am
Location: Off Campus Location
Organized By: The Center for the Study of Complex Systems

ZOOM MEETING LINK: myumi.ch/v2ZYv

Re-scheduled from earlier this fall.

ABSTRACT:
Why is it so difficult to develop a systematic approach to modulate the recovery of consciousness from pharmacologically and pathologically induced unconsciousness? Three things are required to develop a systematic approach; a reliable neural activity that corresponds to consciousness, a reliable brain stimulation to induce the target neural activity, and a mechanism to guarantee the induced neural activity results in consciousness. However, no single neural activity or a mechanism has been identified yet as a neural correlate of consciousness, suggesting that consciousness might emerge through complex interactions of spatially and temporally distributed brain functions. Accumulating evidence from computational model and empirical studies suggest that brain criticality – a balanced state between order and disorder, stability and instability, incoherent and synchronized connectivity at a global network level, is a necessary condition for the emergence of consciousness. Thus, in our research project, we hypothesized that with modulating brain network criticality, we may be able to control the state transition during the loss and recovery of consciousness in general anesthesia and coma. In this talk, I will introduce our current project that aims to develop a systematic method to precisely evaluate a brain state in altered states of consciousness and to control the emergence from unconsciousness, which is based on highly advanced methods in physics, network science, and neurobiology of consciousness.

Please join us 15 minutes before and after the seminar for a social coffee hangout. Put your speakers and video on and say hi to old friends or go to the 'lounge' and chat with an acquaintance

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Livestream / Virtual Mon, 23 Nov 2020 16:33:23 -0500 2020-12-01T11:30:00-05:00 2020-12-01T13:00:00-05:00 Off Campus Location The Center for the Study of Complex Systems Livestream / Virtual Photo of UnCheol Lee
Human Capital, History, Demography & Development (H2D2): Combating COVID-19: Measuring and Changing Beliefs, Knowledge, and Behaviors - Part 2 (December 1, 2020 11:30am) https://events.umich.edu/event/78925 78925-20154734@events.umich.edu Event Begins: Tuesday, December 1, 2020 11:30am
Location: Off Campus Location
Organized By: Department of Economics

To join the seminar, please visit the following webpage.
https://sites.google.com/view/h2d2/seminars

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Workshop / Seminar Tue, 17 Nov 2020 17:23:48 -0500 2020-12-01T11:30:00-05:00 2020-12-01T12:50:00-05:00 Off Campus Location Department of Economics Workshop / Seminar Econ Umich
MIPSE Seminar | Exploring Transformative Startup Solutions for Magnetically Confined Fusion Plasmas (December 2, 2020 3:30pm) https://events.umich.edu/event/76473 76473-19717165@events.umich.edu Event Begins: Wednesday, December 2, 2020 3:30pm
Location: Off Campus Location
Organized By: Michigan Institute for Plasma Science and Engineering (MIPSE)

The seminar is free and open to the public.
To request the Zoom link, please send an email to:
mipse-central@umich.edu

Abstract:
The potential to use fusion as a carbon-free, fuel-abundant energy source to meet the world’s growing energy demands has motivated significant US and international research. One research path to realize fusion energy involves tokamaks that magnetically confine hot plasmas in the shape of a torus. Almost every tokamak fusion reactor in the world relies on magnetic induction from a central solenoid to drive the current necessary to create a fusion grade plasma. Minimizing or eliminating the need for a central solenoid in a tokamak would greatly simplify the construction and reduce the cost of these devices, increasing their viability for commercial energy production. Solenoid-free startup techniques such as helicity injection (HI) and radiofrequency (RF) wave injection offer the potential of reducing the technical requirements of, or possibly the need for, a central solenoid. A major upgrade is underway for the spherical tokamak, Pegasus-III at the U of Wisconsin. The new facility will be a dedicated US platform to study innovations in plasma startup techniques, allowing for studies of both HI and RF during plasma initiation, ramp-up and sustainment. Experimental plans for RF heating and current drive in the microwave regime will be presented. The new capabilities of Pegasus-III will provide a bold test of the viability of a non-solenoidal compact tokamak using reactor relevant techniques.

About the Speaker:
Prof. Diem’s research interests are in experimental plasma physics for fusion energy development with emphasis on validating numerical models with experimental data. She focuses on utilizing radio frequency (RF) waves to heat and drive current in magnetically confined plasmas. Prof. Diem’s current research is focused on electron Bernstein wave and electron cyclotron heating and current drive experiments on Pegasus-III at UW-Madison as well as collaborations domestically and internationally on RF injection in magnetically confined fusion plasmas. Prof. Diem received her PhD in Plasma Physics from Princeton U. where she developed diagnostics to study electron Bernstein wave emission and mode conversion on the National Spherical Tokamak at the Princeton Plasma Physics Lab. She received a BS in Nuclear Engineering & Engineering Physics from UW-Madison. Prior to joining the faculty at UW-Madison, Prof. Diem was a Research and Development Staff Scientist in the Fusion Energy Division at Oak Ridge National Lab. and was on long-term assignment at the DIII-D National Fusion Facility at General Atomics in San Diego, CA.

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Livestream / Virtual Tue, 01 Sep 2020 11:32:57 -0400 2020-12-02T15:30:00-05:00 2020-12-02T16:30:00-05:00 Off Campus Location Michigan Institute for Plasma Science and Engineering (MIPSE) Livestream / Virtual Prof. Stephanie Diem
DCMB / CCMB Weekly Seminar (December 2, 2020 4:00pm) https://events.umich.edu/event/79631 79631-20436379@events.umich.edu Event Begins: Wednesday, December 2, 2020 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

ABSTRACT: The brain is made of networks of neurons that send information to each other via spikes. Sleep and wake are the most clearly definable brain states and each exerts unique effects upon neural network spiking activity. We used large-scale recordings in the frontal cortex of mice and rats to examine the activity of neurons during wake/sleep cycles and found that a novel form of homeostatic action is taken by sleep: homogenization of firing rates. Whereas it was previously believed that sleep simple decreased firing rates, we found that this was much more true of the most active neurons only, thereby reducing the variance of the population.

To extend this observation of homeostatic forced during sleep we also examine how sleep and wake states interact with learning and performance, which is also facilitated by sleep. We have therefore begun to record before, during and after learning sessions to determine how learning interacts with the usual homeostatic effects of sleep. Further we can also record how waking changes in brain states such as motivation and attention modulate firing and information processing by neurons during behavior itself.

Finally, our end-goal to translate these kinds of basic neurobiologic observations in healthy rodents to states of stress or treatments of stress. Unfortunately the chronic stress states of relevance to psychiatric disease do not last seconds but days and weeks. We have therefore begun to build new long-term recording environments to enable future experiments over these time-spans.

BIOGRAPHY:
Dr. Watson is an assistant professor in psychiatry at the University of Michigan. He grew up in Ann Arbor and then obtained his BA from Cornell University and his M.D. and Ph.D. degrees from Columbia University. During his Ph.D. he used two-photon microscopy to study the behavior of neurons in local cortical microcircuits. During his doctoral work he also participated in technical development of multi-beam two photon imaging techniques. Upon graduation from medical school, Dr. Watson pursued a residency in Psychiatry at Weill Cornell Medical College as well postdoctoral work at New York University. He received the National Institute for Mental Health’s Outstanding Resident Award, the American Psychiatric Association’s Lilly Research Fellowship and the Leon Levy Neuroscience Fellowship. He did a fellowship with Dr. Gyorgy Buzsaki at NYU to record ongoing activity in naturally behaving and sleeping animals wherein he showed that sleep reorganizes neuronal firing architecture in the neocortex in previously unknown ways. He is now combining his electrical recordings with behavioral tools to deepen his understanding of both use and regulation of cortical brain circuits.

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Tue, 01 Dec 2020 09:45:44 -0500 2020-12-02T16:00:00-05:00 2020-12-02T17:00:00-05:00 Off Campus Location DCMB Seminar Series Livestream / Virtual
Michael Beauregard Seminar in Macroeconomics (December 2, 2020 4:00pm) https://events.umich.edu/event/79061 79061-20184345@events.umich.edu Event Begins: Wednesday, December 2, 2020 4:00pm
Location: Off Campus Location
Organized By: Department of Economics

Abstract:
Details to come.

* To join the seminar, please contact at econ.events@umich.edu

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Workshop / Seminar Mon, 09 Nov 2020 17:19:16 -0500 2020-12-02T16:00:00-05:00 2020-12-02T17:00:00-05:00 Off Campus Location Department of Economics Workshop / Seminar Econ Umich
“Mesenchymal Regulation of Tooth Root Formation and Eruption” (December 3, 2020 12:00pm) https://events.umich.edu/event/79611 79611-20430435@events.umich.edu Event Begins: Thursday, December 3, 2020 12:00pm
Location: Off Campus Location
Organized By: Office of Research School of Dentistry

Wanida Ono, PhD
Assistant Professor, Orthodontics and Pediatric Dentistry
University of Michigan School of Dentistry

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Workshop / Seminar Mon, 30 Nov 2020 14:32:33 -0500 2020-12-03T12:00:00-05:00 2020-12-03T13:00:00-05:00 Off Campus Location Office of Research School of Dentistry Workshop / Seminar Ono
BME Seminar Series: Jae-Won Shin (December 3, 2020 4:00pm) https://events.umich.edu/event/75912 75912-19623830@events.umich.edu Event Begins: Thursday, December 3, 2020 4:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Join us for our virtual seminar series on Thursdays from 4-5pm!
These events will take place on BlueJeans at this link: https://bluejeans.com/628109990

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Workshop / Seminar Thu, 20 Aug 2020 14:28:28 -0400 2020-12-03T16:00:00-05:00 2020-12-03T17:00:00-05:00 Off Campus Location Biomedical Engineering Workshop / Seminar BME
Statistics Department Seminar Series: Yinqiu He, PhD Candidate, Department of Statistics, University of Michigan (December 4, 2020 10:00am) https://events.umich.edu/event/79568 79568-20382970@events.umich.edu Event Begins: Friday, December 4, 2020 10:00am
Location: Off Campus Location
Organized By: Department of Statistics

Abstract:
In scientific research that involves large-scale data, researchers often start with questions regarding the global properties of a large set of measurements. For instance, are a group of related genes in the same functional pathway jointly associated with a trait of interest? Such questions can be formulated as hypothesis testing problems that globally examine a large number of parameters in a high-dimensional joint distribution. Examples include hypothesis testing on mean vectors, covariance matrices and regression coefficients. To extract informative scientific knowledge from abundant data, reliability and efficiency are among the major concerns in statistical inference.

In this talk, I will address particular reliability and efficiency issues arising from jointly testing a large number of parameters. First, I will discuss how reliable the popular likelihood ratio tests (LRTs) are in terms of the type I error control for high-dimensional data. I will present statistically principled guidelines on the reliability of the LRTs in a variety of problems, which are based on phase transition results of the foundational Wilk’s theorem. Next, to improve efficiency of the existing testing procedures under high-dimensional settings, I will introduce a new adaptive testing framework that can maintain high statistical power against a wide range of alternative hypotheses. The proposed framework is based on a family of U-statistics that are constructed to capture the information in different directions in high-dimensional spaces. For a broad class of problems, we establish high-dimensional asymptotic theory for the U-statistics and develop adaptive testing procedures that are statistically powerful in a wide variety of scenarios.

This seminar will be livestreamed via Zoom https://umich.zoom.us/j/94350208889
There will be a virtual reception to follow.

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Workshop / Seminar Tue, 24 Nov 2020 15:18:56 -0500 2020-12-04T10:00:00-05:00 2020-12-04T11:00:00-05:00 Off Campus Location Department of Statistics Workshop / Seminar Yinqiu He
Biophysics Seminar Series (December 4, 2020 12:00pm) https://events.umich.edu/event/77923 77923-19941588@events.umich.edu Event Begins: Friday, December 4, 2020 12:00pm
Location: Off Campus Location
Organized By: LSA Biophysics

The Biophysics Virtual Seminar Series presents:

Dr. Oleg Igoshin - Professor of Bioengineering & BioSciences, Associate Chair of Bioengineering, Rice University

*“Understanding Trade-offs in Biological Error Correction”*

Join us on Zoom: https://umich.zoom.us/j/96475935279

Abstract: High accuracy of major biological processes relies on the ability of the participating enzymatic molecules to preferentially select the correct substrate from a pool of chemically similar substrates by activating the so-called proofreading mechanisms. While the importance of such mechanisms is widely accepted, it is still unclear how evolution has optimized the biological systems with respect to their characteristic properties. We developed a comprehensive first-passage theoretical framework that allowed us to quantitatively investigate the trade-offs between four properties of enzymatic systems namely, error, speed, noise and energy dissipation. Within this framework, we simultaneously analyzed speed and accuracy of several fundamental biological processes, including DNA replication, tRNA charging, and tRNA selection during the translation. The results indicate that contrary to typical assumptions speed-accuracy trade-off is not always observed. However, when the trade-off is present, the biological systems tend to optimize the speed rather than the accuracy of the processes, as long as the error level is tolerable. When systems function in the regime where no speed-accuracy trade-off is observed, constraints due to energy dissipation in the proofreading play a key role. Our theory demonstrates a universal Pareto front in error-dissipation trade-off and shows how naturally selected kinetic parameters position their system close to this boundary. Our findings, therefore, provide a new system-level picture of how complex biological processes are able to function so fast with a high accuracy and low dissipation.

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Livestream / Virtual Tue, 01 Dec 2020 08:40:21 -0500 2020-12-04T12:00:00-05:00 2020-12-04T13:00:00-05:00 Off Campus Location LSA Biophysics Livestream / Virtual Dr. Igoshin
MCDB Virtual Seminar: Receptors, channels and animal behavior (December 4, 2020 12:00pm) https://events.umich.edu/event/72767 72767-19848086@events.umich.edu Event Begins: Friday, December 4, 2020 12:00pm
Location: Off Campus Location
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Bo Duan

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Workshop / Seminar Mon, 26 Oct 2020 14:45:08 -0400 2020-12-04T12:00:00-05:00 2020-12-04T14:00:00-05:00 Off Campus Location Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar MCDB initials & microscope drawing in yellow on a blue square
Cognitive Science Seminar: "Cognitive Tools for Learning and Communication" (virtual) (December 7, 2020 2:30pm) https://events.umich.edu/event/76965 76965-19782527@events.umich.edu Event Begins: Monday, December 7, 2020 2:30pm
Location: Off Campus Location
Organized By: Weinberg Institute for Cognitive Science

Dr. Judith Fan, Assistant Professor in the Department of Psychology, UC San Diego, will give a talk titled "Cognitive Tools for Learning and Communication."

ABSTRACT

How does the human mind transform a cascade of sensory information into meaningful knowledge? While traditional approaches to learning focus on how people process the data provided to them by the world, this approach leaves aside all of the powerful tools people have to actively reformat their experiences and generate new ones. For example, we choose what to look at, bring certain memories to mind, produce pictures to share, and compose stories to tell. The goal of our lab’s research is to “reverse engineer” the core mechanisms by which employing such cognitive tools enable humans to learn and communicate more effectively. Our recent work focuses on visual communication, one of our most basic and versatile tools, because it also represents a key challenge for understanding how multiple cognitive systems interact to support complex, natural behaviors. This talk will highlight our recent progress, as well as open research questions in this domain.

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Livestream / Virtual Mon, 07 Dec 2020 11:22:51 -0500 2020-12-07T14:30:00-05:00 2020-12-07T16:00:00-05:00 Off Campus Location Weinberg Institute for Cognitive Science Livestream / Virtual Judith Fan
Forecasting and Stochastic Programming Models to Address Uncertainty in the Trauma System Configuration Problem (December 7, 2020 4:30pm) https://events.umich.edu/event/79689 79689-20454252@events.umich.edu Event Begins: Monday, December 7, 2020 4:30pm
Location: Off Campus Location
Organized By: Center for Healthcare Engineering & Patient Safety (CHEPS)

Trauma care services are a vital part of all healthcare-based network as timely accessibility is important for citizens. Trauma care access is even more relevant when unexpected events such as the COVID-19 pandemic overload the capacity of the hospitals. Research literature has highlighted that access to trauma care is not even for all populations, especially when comparing rural and urban groups. Historically, the configuration of a trauma system was often not considered as a whole but instead hinged on the designation and verification of individual hospitals as trauma care centers. Recognition of the benefits of an inclusive trauma system has precipitated a more holistic approach. The optimal geographic configuration of trauma care centers is key to maximizing accessibility while promoting the efficient use of resources. This talk focuses on analyzing and forecasting physical trauma sustained from accidents, in environments both personal and work related, pertaining to individual injuries and to formulate a stochastic programming model that utilizes recorded injuries as demands to place trauma centers in the most optimal location. The first part of the talk discusses the limitations faced by the existing trauma healthcare infrastructure by forecasting the expected number of people requiring the services of trauma facilities for both rural and urban locations in Texas. Five types of forecasting methods were analyzed to determine the best option to utilize for forecasting for individual data sets. The aim is to identify which forecasting model performs the best for given data sets that can be used to forecast patient demand for a given location and determine the optimal locations for trauma network expansion. The second part of the talk reports on the development of a two-stage stochastic optimization model for geospatial expansion of a trauma network in the state of Texas. The stochastic optimization model recommends the siting of new trauma care centers according to the geographic distribution of the injured population. The model has the potential to benefit both patients and institutions, by facilitating prompt access and promoting the efficient use of resources.

Eduardo Pérez is an Associate Professor in the Ingram School of Engineering at Texas State University. He was a Postdoctoral Research Associate in the Department of Industrial and Systems Engineering at Texas A&M University from 2010 to 2012. He received his PhD in Industrial and Systems Engineering from Texas A&M University in 2010 and his B.S. in Industrial Engineering from the University of Puerto Rico at Mayagüez, Puerto Rico in 2004. Dr. Pérez’s research interests are in the use of methodologies and theories in operations research, systems engineering, discrete-event simulation, algorithms and software design, and decision theory analysis to solve problems in service systems. Some of his research project sponsors include the National Science Foundation (NSF), the Department of Homeland Security (DHS), the Robert Wood Johnson Foundation, Baylor Scott & White Health System, Adventist Health System, and the NEC Corporation. Dr. Eduardo Pérez is a member of the Institute of Industrial Engineers (IIE), the Institute for Operations Research and Management Sciences (INFORMS), and the Society for Computer Simulation International (SCS). He received his Engineering-In-Training (EIT) certification in 2004. He is the director of the Integrated Modeling and Optimization for Service Systems (iMOSS) research laboratory.

For a full listing of our Fall 2020 seminars, see https://cheps.engin.umich.edu/seminar-series/2020-seminar/

This seminar series is presented by the U-M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi-disciplinary, systems-engineering approach.
For the Zoom link and password and to be added to the weekly e-mail for the series, please RSVP.
For additional questions, contact CHEPSseminar@umich.edu.
Photographs, screen captures, and video taken at this event may be used to promote CHEPS, College of Engineering, and the University.

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Lecture / Discussion Thu, 03 Dec 2020 15:50:46 -0500 2020-12-07T16:30:00-05:00 2020-12-07T17:30:00-05:00 Off Campus Location Center for Healthcare Engineering & Patient Safety (CHEPS) Lecture / Discussion Eduardo Pérez, Ph.D.
Social, Behavioral & Experimental Economics (SBEE): Collaborative Dishonesty: A Meta-Study (December 8, 2020 10:00am) https://events.umich.edu/event/78687 78687-20105422@events.umich.edu Event Begins: Tuesday, December 8, 2020 10:00am
Location: Off Campus Location
Organized By: Department of Economics

Abstract:
Whereas dishonesty is often a result of collaborative efforts, it is commonly studied in individual settings. We present the first meta-study on collaborative dishonesty, reviewing 51,640 decisions, made by 3,264 individuals. Results reveal that people are influenced by their partners’ lies: They lie more (i) in collaborative than in individual settings, (ii) when their partners lie, and (iii) in later stages of the interaction.

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Workshop / Seminar Tue, 20 Oct 2020 11:04:37 -0400 2020-12-08T10:00:00-05:00 2020-12-08T11:15:00-05:00 Off Campus Location Department of Economics Workshop / Seminar Econ Umich
Human Capital, History, Demography & Development (H2D2): The Impact of Trade on Development: Evidence from Pastoralist Practices on the Ancient Silk Road/ Effects of Paid Family Leave on Older Adults (December 8, 2020 11:30am) https://events.umich.edu/event/78923 78923-20154733@events.umich.edu Event Begins: Tuesday, December 8, 2020 11:30am
Location: Off Campus Location
Organized By: Department of Economics

To join the seminar, please visit the following webpage.
https://sites.google.com/view/h2d2/seminars

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Workshop / Seminar Tue, 17 Nov 2020 17:25:09 -0500 2020-12-08T11:30:00-05:00 2020-12-08T12:50:00-05:00 Off Campus Location Department of Economics Workshop / Seminar Econ Umich
Department of Computational Medicine & Bioinformatics Weekly Wednesday Seminar (December 9, 2020 4:00pm) https://events.umich.edu/event/79756 79756-20484062@events.umich.edu Event Begins: Wednesday, December 9, 2020 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Learning objectives:

1. Discuss the conceptual distinction and clinical utility of self-reported race/ethnicity and genetic ancestry in childhood asthma.
2. Discuss the role of genetic ancestry and socio-environmental exposures in childhood asthma.
3. Discuss ancestry-specific polygenic risk scores, precision medicine and childhood asthma disparities.

Short bio: Dr. Mersha is currently an Associate Professor in the Division of Asthma Research and leads the Population Genetics, Ancestry, and Bioinformatics (pGAB) Laboratory (https://research.cchmc.org/mershalab/Home.php).
Dr. Mersha’s research combines quantitative, ancestry and statistical genomics to unravel genetic and non-genetic contributions to complex diseases and racial disparities in human populations, particularly asthma and asthma-related allergic disorders. Much of his research is at the interface of genetic ancestry, statistics, bioinformatics, and functional genomics, and he is interested in cross-line disciplines to unravel the interplay between genome and envirome underlying asthma risk. His long-term research goal is to understand and dissect how biologic predisposition and environmental exposures interact to shape racial disparities in complex disorders.

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Livestream / Virtual Mon, 07 Dec 2020 11:27:42 -0500 2020-12-09T16:00:00-05:00 2020-12-09T17:15:00-05:00 Off Campus Location DCMB Seminar Series Livestream / Virtual Tesfaye ("Tes") Mersha, PhD (Associate Professor, Division of Asthma Research at Cincinnati Children's Hospital Medical Center)
Human Capital, History, Demography & Development (H2D2): Income Effects in Early Childhood/ Do Urgent Care Centers Increase Access to Care and Decrease Healthcare Costs? (December 15, 2020 11:30am) https://events.umich.edu/event/78926 78926-20154735@events.umich.edu Event Begins: Tuesday, December 15, 2020 11:30am
Location: Off Campus Location
Organized By: Department of Economics

To join the seminar, please visit the following webpage.
https://sites.google.com/view/h2d2/seminars

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Workshop / Seminar Mon, 26 Oct 2020 14:17:39 -0400 2020-12-15T11:30:00-05:00 2020-12-15T12:50:00-05:00 Off Campus Location Department of Economics Workshop / Seminar Econ Umich
Data Science Coast to Coast Presents: Dr. Jeanne Holm (December 15, 2020 3:00pm) https://events.umich.edu/event/78800 78800-20125167@events.umich.edu Event Begins: Tuesday, December 15, 2020 3:00pm
Location: Off Campus Location
Organized By: Michigan Institute for Data Science

The DS C2C seminar series, hosted jointly by six academic data science institutes, provides a unique opportunity to foster a broad-reaching data science community.

This fall, the series features important figures in data science, who will provide insight on the transformative use of data science in traditional research disciplines, future breakthroughs in data science research, data science entrepreneurship, and advocacy and national policies for a data-enabled and just society.

Speakers throughout the winter and spring will include faculty members and postdoctoral fellows at the six universities whose research spans the theory and methodology of data science, and their application in arts and humanities, engineering, biomedical, natural, physical and social sciences.

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Presentation Thu, 22 Oct 2020 23:08:05 -0400 2020-12-15T15:00:00-05:00 2020-12-15T16:00:00-05:00 Off Campus Location Michigan Institute for Data Science Presentation Data Science: Coast 2 Coast
THE CHANGING LANDSCAPE OF BIOMEDICAL DATA COLLECTIONS (December 21, 2020 4:00pm) https://events.umich.edu/event/79454 79454-20327789@events.umich.edu Event Begins: Monday, December 21, 2020 4:00pm
Location: Off Campus Location
Organized By: Michigan Institute for Data Science

Abstract:

The landscape of biomedical data is incredibly complex, rich, and rapidly changing, especially as we navigate the influx of data from the COVID-19 pandemic. More and more data is moving to the cloud, both existing and newly generated, with multiple cloud providers adding to the complexity. The data includes Electronic Health Records (EHRs), genomic data, and imaging/sensed data (e.g., pictures of tumors, lungs, cells, gas chromatographs), and all this data is enabling us to delve much deeper into complex biological concepts, for example, the relationship between phenotypes and genotypes. The NHLBI BioData Catalyst project is one example of a coordinated effort to move vast amounts of data into the cloud, navigating the complexities of data ingestion, diverse and widespread teams, and multiple cloud providers/environments.

On top of the massive shift to being able to apply huge amounts of data to better understand individuals, populations and, ultimately, life itself, we need a way to organize all this information. The activities in the NCATS Biomedical Data Translator project can be viewed as a constantly evolving analysis of the relationships of disparate data sets. In a sense, Translator is like Google for searching biomedical data.

My talk will introduce both projects and their respective impacts on biomedical research.

Bio:

Dr. Stan Ahalt is the Director of the Renaissance Computing Institute (RENCI) at UNC-Chapel Hill. As Director, he leads a team of research scientists, software and network engineers, data science specialists, and visualization experts who work closely with faculty research teams at UNC, Duke, NCSU, and partners across the country. Dr. Ahalt is also a Professor in UNC’s Department of Computer Science and the Associate Director of Informatics and Data Science (IDSci) in the North Carolina Translational and Clinical Sciences Institute (NC TraCS), UNC’s CTSA award; in this role, Dr. Ahalt leverages the expertise and resources of RENCI to foster clinical and translational research across UNC’s campus. Dr. Ahalt earned his Ph.D. in Electrical and Computer Engineering from Clemson University and has over 30 years of experience in data science, signal and image processing, and pattern recognition/ML.

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Presentation Mon, 23 Nov 2020 12:01:11 -0500 2020-12-21T16:00:00-05:00 2020-12-21T17:00:00-05:00 Off Campus Location Michigan Institute for Data Science Presentation Stan Ahalt
Social, Behavioral & Experimental Economics (SBEE): Social Learning in Groups: an Experimental Study (January 13, 2021 1:00pm) https://events.umich.edu/event/79776 79776-20491896@events.umich.edu Event Begins: Wednesday, January 13, 2021 1:00pm
Location: Off Campus Location
Organized By: Department of Economics

Abstract:
A large literature in economics and finance has shown the dangers associated with — and the inefficiencies that arise from — the imitation of others’ actions, and from herd behavior in particular. We contribute to this literature by providing empirical evidence of the benefits of imitation in repeated social learning environments. We show experimentally that observing the actions of others improves the quality of decisions and leads to higher information aggregation rates, even in settings where the actions of others do not provide additional information, beyond the private information available to agents.
Specifically, we conduct a series of controlled laboratory experiments, in which subjects repeatedly try to estimate an unknown state of nature while observing private information that arrives sequentially, and, depending on the treatment, additional observations of others. There are no direct externalities in this setting, and each subject is rewarded independently of others for estimating correctly. Between treatments, we vary the information available to subjects at the time they make their guesses. This simple setting allows us to address two questions. First, we document whether at all and to what extent people are capable of extracting the information contained in their peers’ private signals by observing their actions, in a repeated setting. Second, we study the usefulness of observing other people’s decisions when private signals of others are also available, and, thus, others' actions should be irrelevant.

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Workshop / Seminar Tue, 08 Dec 2020 09:10:32 -0500 2021-01-13T13:00:00-05:00 2021-01-13T14:15:00-05:00 Off Campus Location Department of Economics Workshop / Seminar Econ Umich
Biophysics Seminar Series (January 15, 2021 12:00pm) https://events.umich.edu/event/80417 80417-20719670@events.umich.edu Event Begins: Friday, January 15, 2021 12:00pm
Location: Off Campus Location
Organized By: LSA Biophysics

The Biophysics Virtual Seminar Series presents:

Dr. Michele Vendruscolo - Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge

*“Activity Relationship by Kinetics for Drug Discovery in Protein Misfolding Diseases”*

ABSTRACT: Protein oligomers are increasingly recognized as the most cytotoxic forms of protein aggregates. It has been very challenging, however, to target these oligomers with therapeutic compounds, because of their dynamic and transient nature. To overcome this problem, I will describe a 'structure kinetic-activity relationship' (SKAR) approach, which enables the discovery and systematic optimization of compounds that reduce the number of oligomers produced during an aggregation reaction. I will illustrate this strategy for the amyloid beta peptide, which is closely associated with Alzheimer's disease, by developing a rhodanine compound capable of dramatically reducing the production of amyloid beta oligomers. As this strategy is general, it can be applied to oligomers of any protein.

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Livestream / Virtual Wed, 06 Jan 2021 10:17:32 -0500 2021-01-15T12:00:00-05:00 2021-01-15T13:00:00-05:00 Off Campus Location LSA Biophysics Livestream / Virtual Dr. Michele Vendruscolo