Happening @ Michigan https://events.umich.edu/list/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. DCM&B Tools and Technology Seminar (January 20, 2022 12:00pm) https://events.umich.edu/event/89769 89769-21665747@events.umich.edu Event Begins: Thursday, January 20, 2022 12:00pm
Location: Off Campus Location
Organized By: DCMB Tools and Technology Seminar

This presentation will be given remotely, with the livestream available via Zoom.

]]>
Presentation Mon, 17 Jan 2022 10:08:14 -0500 2022-01-20T12:00:00-05:00 2022-01-20T13:00:00-05:00 Off Campus Location DCMB Tools and Technology Seminar Presentation
Structure-Function Relationships of Single Fluorescent Macromolecules (January 20, 2022 4:00pm) https://events.umich.edu/event/88613 88613-21656201@events.umich.edu Event Begins: Thursday, January 20, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

When chemical reactivity is measured for a series of systematically related molecules, a structure-function relationship can be derived that summarizes the effect of the perturbation. This seminar will develop the idea of studying chemistry with single molecule structure-function relationships. In our implementation, optical tweezers are used to isolate a tethered single molecule and apply a force bias to create sub-ensembles of well-defined extension. For fluorescent molecules, the intrinsic optical emission can provide a probe of function. Ongoing research will be discussed, including an investigation into the green fluorescent family of proteins. These proteins share a common chromophore capable of a diverse range of photochemistries (electron transfer, proton transfer, isomerization, oxidative addition) whose reactivity is determined by subtle environmental changes.



Ziad Ganim (Yale University)

]]>
Other Thu, 20 Jan 2022 18:15:29 -0500 2022-01-20T16:00:00-05:00 2022-01-20T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Warren Herb Wagner Virtual Guest Lecture in Plant Evolution: Untangling the cryptic biology of the world’s largest flowers (January 20, 2022 4:00pm) https://events.umich.edu/event/85733 85733-21628572@events.umich.edu Event Begins: Thursday, January 20, 2022 4:00pm
Location: Off Campus Location
Organized By: Ecology and Evolutionary Biology

Charles Davis is Professor of Biology at Harvard University and Curator of Vascular Plants at the Harvard University Herbaria. He uses collections-oriented and phylogenetic research to investigate plant evolution and ecology in a variety of tropical and temperate clades.

Abstract
Parasitic plants have remained a great mystery in the flowering plant tree of life. Among the most iconic and bizarre are the Rafflesiaceae, which produce the world’s largest flowers. I will illustrate our efforts to untangle evolutionary relationships of this charismatic family, expose the developmental underpinnings of their massive flowers, and reveal the genomic basis of extreme plant parasitism.

Image copyright: Jeremy Holden

]]>
Livestream / Virtual Mon, 17 Jan 2022 15:17:08 -0500 2022-01-20T16:00:00-05:00 2022-01-20T17:00:00-05:00 Off Campus Location Ecology and Evolutionary Biology Livestream / Virtual Rafflesia arnoldii, copyright Jeremy Holden
Grad School Interviews Office Hour (January 21, 2022 10:00am) https://events.umich.edu/event/91167 91167-21677027@events.umich.edu Event Begins: Friday, January 21, 2022 10:00am
Location: Off Campus Location
Organized By: Futures in Research, Science, Teaching - FIRST

If you would like to ask current biology grad students about what interviewing at different grad programs is like, or practice interviewing yourself, please stop by.

Zoom link: https://umich.zoom.us/j/99108550897

]]>
Workshop / Seminar Tue, 18 Jan 2022 11:11:32 -0500 2022-01-21T10:00:00-05:00 2022-01-21T11:00:00-05:00 Off Campus Location Futures in Research, Science, Teaching - FIRST Workshop / Seminar FIRST Logo with the name made out of chromosomes separating during mitosis.
U-M Structure Seminar: "Structural and dynamics investigation of NPSL2 by NMR" (January 21, 2022 10:00am) https://events.umich.edu/event/85434 85434-21626421@events.umich.edu Event Begins: Friday, January 21, 2022 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

Yaping Liu, Ph.D.
Postdoctoral Research Fellow
University of Michigan, Sarah Keane Lab

Hybrid: LSI Library and Zoom - https://umich.zoom.us/j/97763780708 (Password: structure)

]]>
Workshop / Seminar Mon, 03 Jan 2022 13:13:44 -0500 2022-01-21T10:00:00-05:00 2022-01-21T11:00:00-05:00 Life Sciences Institute U-M Structural Biology Workshop / Seminar U-M Structure
Bridging structural biology and virology: imaging processes in the native cellular context at molecular resolution (January 24, 2022 11:30am) https://events.umich.edu/event/90559 90559-21671685@events.umich.edu Event Begins: Monday, January 24, 2022 11:30am
Location: Taubman Biomedical Science Research Building
Organized By: U-M Structural Biology

Correlative Light and Electron Microscopy (CLEM) Faculty Candidate Seminar

Luiza Mendonca, Ph.D.
Research Fellow, Wellcome Centre for Human
Genetics, Division of Structural Biology
(STRUBI), University of Oxford

Hosted By:
Department of Cell and Developmental Biology
Life Science Institute
Biosciences Initiative

]]>
Lecture / Discussion Thu, 06 Jan 2022 12:20:14 -0500 2022-01-24T11:30:00-05:00 2022-01-24T12:30:00-05:00 Taubman Biomedical Science Research Building U-M Structural Biology Lecture / Discussion Luiza
Bridging structural biology and virology: imaging processes in the native cellular context at molecular resolution (January 24, 2022 11:30am) https://events.umich.edu/event/90645 90645-21672069@events.umich.edu Event Begins: Monday, January 24, 2022 11:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

The Department of Cell and Developmental Biology and Life Science Institute cryo-EM Biosciences Initiative is pleased to welcome Luiza Montenegro Mendonca, Ph.D. to speak on January 24th, 2022 from 11:30am – 12:30pm.

This event is a Correlative Light and Electron Microscopy (CLEM) Faculty Candidate Seminar.

The title of the seminar is “Bridging structural biology and virology: imaging processes in the native cellular context at molecular resolution” and is scheduled both in-person (BSRB – ABC) and virtual Zoom Meeting link: https://umich.zoom.us/j/93704315949

]]>
Lecture / Discussion Fri, 07 Jan 2022 10:05:19 -0500 2022-01-24T11:30:00-05:00 2022-01-24T12:30:00-05:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion Bridging structural biology and virology: imaging processes in the native cellular context at molecular resolution
Oral Health Sciences Master's Program Information Session (January 24, 2022 1:00pm) https://events.umich.edu/event/87517 87517-21642910@events.umich.edu Event Begins: Monday, January 24, 2022 1:00pm
Location: Off Campus Location
Organized By: Office of Research School of Dentistry

This is a virtual information session for prospective Oral Health Sciences Master's students. You can listen to a brief presentation from the program director and there will be time for questions and answers.
Please Register to receive a Zoom link.

]]>
Meeting Fri, 24 Sep 2021 15:03:50 -0400 2022-01-24T13:00:00-05:00 2022-01-24T14:00:00-05:00 Off Campus Location Office of Research School of Dentistry Meeting logo
Programmable Biomaterials/Regenerative Medicine Grand Challenge (January 24, 2022 1:00pm) https://events.umich.edu/event/88715 88715-21677237@events.umich.edu Event Begins: Monday, January 24, 2022 1:00pm
Location: Off Campus Location
Organized By: Regenerative Medicine Biosciences Initiative

Programmable Biomaterials/Regenerative Medicine Grand Challenge #1

Theme: How to regenerate tissues/organs to optimally integrate with the host

Goal: Bring together clinicians, scientists, and engineers to explore new ideas and catalyze new collaborations to address key barriers to the translation of regenerative medicine technologies

Format: Short talks identifying clinical problems and emerging technologies, followed by breakout sessions to identify opportunities

Breakouts: Based on problems identified, what are transformative things UM can do to solve? We’re looking for big ideas that involve new, heterogeneous groups. Themes/challenges that emerge from breakouts will define an RFA

Outcome: Funding for collaborative proposals that emerge from the grand challenge session w/ criteria that proposals are novel and integrative, satisfying one or more of the following elements:
•High risk, cross-cutting, transformative
•Leverage strengths at UM in new ways
•Pull together new combinations of people
•Tackle new problems or existing problems in new ways
•Topics that will have greatest impact and potential for extramural funding
•We anticipate awarding 3 grants at ~100K each
Please join us for our 2-day VIRTUAL event January 24 and January 25.

]]>
Workshop / Seminar Tue, 18 Jan 2022 19:32:41 -0500 2022-01-24T13:00:00-05:00 2022-01-24T18:30:00-05:00 Off Campus Location Regenerative Medicine Biosciences Initiative Workshop / Seminar Purple Pipette
Programmable Materials/Regenerative Medicine Grand Challenge-Breakout Sessions (January 25, 2022 9:00am) https://events.umich.edu/event/88716 88716-21656961@events.umich.edu Event Begins: Tuesday, January 25, 2022 9:00am
Location: Off Campus Location
Organized By: Regenerative Medicine Biosciences Initiative

Programmable Biomaterials/Regenerative Medicine Grand Challenge Breakout Rooms

Theme: How to regenerate tissues/organs to optimally integrate with the host

Goal: Bring together clinicians, scientists, and engineers to explore new ideas and catalyze new collaborations to address key barriers to the translation of regenerative medicine technologies

Format: Short talks identifying clinical problems and emerging technologies, followed by breakout sessions to identify opportunities

Breakouts: Based on problems identified, what are transformative things UM can do to solve? We’re looking for big ideas that involve new, heterogeneous groups. Themes/challenges that emerge from breakouts will define an RFA

Outcome: Funding for collaborative proposals that emerge from the grand challenge session w/ criteria that proposals are novel and integrative, satisfying one or more of the following elements:
•High risk, cross-cutting, transformative
•Leverage strengths at UM in new ways
•Pull together new combinations of people
•Tackle new problems or existing problems in new ways
•Topics that will have greatest impact and potential for extramural funding
•We anticipate awarding 3 grants at ~100K each
Please join us for our 2-day VIRTUAL event January 24 and January 25.

]]>
Workshop / Seminar Tue, 18 Jan 2022 19:31:38 -0500 2022-01-25T09:00:00-05:00 2022-01-25T12:00:00-05:00 Off Campus Location Regenerative Medicine Biosciences Initiative Workshop / Seminar Regenerative Medicine Grand Challenge
MCDB Faculty Candidate > Light as a Trigger of Chromatin Dynamics (January 25, 2022 11:45am) https://events.umich.edu/event/90358 90358-21670453@events.umich.edu Event Begins: Tuesday, January 25, 2022 11:45am
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Ming Li

]]>
Workshop / Seminar Fri, 21 Jan 2022 09:16:51 -0500 2022-01-25T11:45:00-05:00 2022-01-25T12:45:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow MCDB initials and microscope cartoon on blue background
The Role of Transmembrane Domains in the Modulation of EGFR Activity- Department of Biological Chemistry Faculty Candidate Seminar (January 25, 2022 12:00pm) https://events.umich.edu/event/90650 90650-21672074@events.umich.edu Event Begins: Tuesday, January 25, 2022 12:00pm
Location: Medical Science Unit I
Organized By: Biological Chemistry

Dr. Deepti Karandar, Postdoctoral Research Associate, UC Berkeley, will present a faculty candidate seminar on Tuesday 1/25/22 at 12:00 noon in room 5330 MS I

]]>
Workshop / Seminar Fri, 07 Jan 2022 10:35:43 -0500 2022-01-25T12:00:00-05:00 2022-01-25T13:00:00-05:00 Medical Science Unit I Biological Chemistry Workshop / Seminar Karandur
MCDB Faculty Candidate > An exploration of cis-regulatory diversity in plant single cells (January 27, 2022 11:45am) https://events.umich.edu/event/90359 90359-21670454@events.umich.edu Event Begins: Thursday, January 27, 2022 11:45am
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Andrzej Wierzbicki

]]>
Workshop / Seminar Mon, 03 Jan 2022 17:10:19 -0500 2022-01-27T11:45:00-05:00 2022-01-27T12:45:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow MCDB initials and microscope cartoon on blue background
DCM&B Tools and Technology Seminar (January 27, 2022 12:00pm) https://events.umich.edu/event/89771 89771-21665751@events.umich.edu Event Begins: Thursday, January 27, 2022 12:00pm
Location: Off Campus Location
Organized By: DCMB Tools and Technology Seminar

Tool link: https://github.com/statgen/savvy

This presentation will be given remotely, with the livestream available via Zoom.

]]>
Presentation Thu, 20 Jan 2022 15:23:09 -0500 2022-01-27T12:00:00-05:00 2022-01-27T13:00:00-05:00 Off Campus Location DCMB Tools and Technology Seminar Presentation
EEB Thursday Seminar: Bone histology as a window into the reproductive strategies of ancient mammals (January 27, 2022 4:00pm) https://events.umich.edu/event/86024 86024-21631131@events.umich.edu Event Begins: Thursday, January 27, 2022 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Our weekly seminar series featuring internal and external speakers in the field of ecology and evolutionary biology.

This in-person event will be livestreamed on Zoom https://umich.zoom.us/j/96295962346

Image: Histological cross section from the femur of a 66-million-year-old multituberculate mammal. Credit: Luke Weaver

]]>
Workshop / Seminar Thu, 27 Jan 2022 12:13:33 -0500 2022-01-27T16:00:00-05:00 2022-01-27T17:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Histological cross section from the femur of a 66-million-year-old multituberculate mammal
TBA (January 27, 2022 4:00pm) https://events.umich.edu/event/86100 86100-21631484@events.umich.edu Event Begins: Thursday, January 27, 2022 4:00pm
Location: Off Campus Location
Organized By: Department of Chemistry

Analytical
Tim Bertram (University of Wisconsin)

]]>
Other Tue, 11 Jan 2022 12:15:27 -0500 2022-01-27T16:00:00-05:00 2022-01-27T17:30:00-05:00 Off Campus Location Department of Chemistry Other
MCDB Dissertation Defense > Investigating the proliferation-quiescence decision in tissues and in cancer cells (January 31, 2022 12:00pm) https://events.umich.edu/event/91611 91611-21681029@events.umich.edu Event Begins: Monday, January 31, 2022 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Mentor: Laura Buttitta

Hybrid event
check the Weekly Update or email: mcdb.seminar.info@umich.edu for zoom link and password

]]>
Workshop / Seminar Thu, 27 Jan 2022 12:44:07 -0500 2022-01-31T12:00:00-05:00 2022-01-31T13:00:00-05:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow MCDB initials Microscope cartoon on blue
RNA Faculty Candidate Seminar (January 31, 2022 4:00pm) https://events.umich.edu/event/89608 89608-21664520@events.umich.edu Event Begins: Monday, January 31, 2022 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

In-person/Hybrid seminar co-hosted by the Center for RNA Biomedicine, the Department of Biological Chemistry and the Department of Biophysics

Talk title: “The scanning mechanism of mRNA translation initiation in humans”

Keywords: mRNA, translation, ribosome, helicase

Abstract: Decoding the genetic information into protein is fundamental for all kingdoms of life. It requires precise mechanisms to transcribe the DNA into mRNA, which then can be translated by the ribosome to produce proteins. Translation initiation of eukaryotic mRNAs is a dynamic process regulated by over a dozen protein eukaryotic initiation factors (eIFs). This process starts with the binding of eukaryotic initiation factors eIF1, eIF1A, eIF3, eIF5, and a ternary complex of eIF2–GTP–tRNAiMet (TC) to the 40S small ribosomal subunit, forming the 43S preinitiation complex (43S PIC). Once assembled, the 43S PIC is recruited to the 5′ untranslated region (UTR) of mRNA by the multifactor cap-binding complex eIF4F, forming the 48S initiation complex (48S). The 48S then scans along the 5′ UTR mRNA to locate a start codon. The eIF4F binding site in the 48S and how mRNA is inserted into the mRNA channel in the 40S small ribosomal subunit remained unknown. To gain insights into the molecular mechanism underlining the assembly of the 48S, we used cryo-electron microscopy to determine the structure of a reconstituted human 48S. The structure sheds light on the early events of translation initiation complex assembly, including how eIF4F interacts with the 43S during the scanning process.

If you are having trouble registering, please contact Martina Jerant at mjerant@umich.edu

]]>
Lecture / Discussion Tue, 04 Jan 2022 11:24:42 -0500 2022-01-31T16:00:00-05:00 2022-01-31T17:00:00-05:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion Jailson (Jay) Brito Querido, MRC Laboratory of Molecular Biology
No Membrane, No Problem: Regulation of Biomolecular Condensates by Protein Clusters- Department of Biological Chemistry Faculty Candidate Seminar (February 1, 2022 12:00pm) https://events.umich.edu/event/90660 90660-21672081@events.umich.edu Event Begins: Tuesday, February 1, 2022 12:00pm
Location: Medical Science Unit I
Organized By: Biological Chemistry

Dr. Andrew Folkmann, Postdoctoral Fellow at Johns Hopkins University, will be presenting a faculty candidate seminar on Tuesday February 1st, 2022 at 12 noon in room 5330 MS I

]]>
Workshop / Seminar Fri, 07 Jan 2022 10:48:59 -0500 2022-02-01T12:00:00-05:00 2022-02-01T13:00:00-05:00 Medical Science Unit I Biological Chemistry Workshop / Seminar Folkmann
"Hepato-Biliary-Pancreatic Organogenesis in a Dish" (February 1, 2022 4:00pm) https://events.umich.edu/event/90540 90540-21671507@events.umich.edu Event Begins: Tuesday, February 1, 2022 4:00pm
Location: Off Campus Location
Organized By: Center for Cell Plasticity and Organ Design

The Center for Cell Plasticity and Organ Design is proud to present the following seminar with speaker Takanori Takebe, MD, PhD. Dr. Takebe is the Chair of Organoid Medicine, member of the Center for Stem Cell and Organoid Medicine (CuSTOM), and within the Divisions of Gastroenterology, Hepatology and Nutrition and Developmental Biology at the Cincinnati Children's Hospital Medical Center.

His talk is entitled, "Hepato-Biliary-Pancreatic Organogenesis in a Dish"

Faculty Host: Idse Heemskerk, PhD, Cell and Developmental Biology

For more info, email Organogenesis@umich.edu

]]>
Livestream / Virtual Thu, 06 Jan 2022 10:53:07 -0500 2022-02-01T16:00:00-05:00 2022-02-01T17:00:00-05:00 Off Campus Location Center for Cell Plasticity and Organ Design Livestream / Virtual Flyer for the Event
Bright chiral light from small molecules (February 1, 2022 4:00pm) https://events.umich.edu/event/91340 91340-21678329@events.umich.edu Event Begins: Tuesday, February 1, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Inorganic
Gael Ung (University of Connecticut)

]]>
Other Tue, 01 Feb 2022 18:15:33 -0500 2022-02-01T16:00:00-05:00 2022-02-01T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Graham Sustainability Scholars Info Session (February 2, 2022 5:30pm) https://events.umich.edu/event/91870 91870-21683698@events.umich.edu Event Begins: Wednesday, February 2, 2022 5:30pm
Location: Off Campus Location
Organized By: Graham Sustainability Institute

Join us on Wednesday, February 2, at 5:30 p.m. for an information session on the Graham Scholars Program! This session will walk you through the process and what you can expect from the program, with time set aside to answer all your questions. Pre-register now or join using the Zoom link here.

Graham Sustainability Scholars form a tight-knit cohort supported, challenged, and inspired by each other, as well as by program partners and advisors.

Through rich co-curricular experiences, Graham Scholars learn to incorporate sustainability into the campus, their lifestyle, their discipline, and the broader community. They have access to professional development and other resources that are designed to enhance academic courses and help build resumes.

Program participants begin the in fall of their junior year and complete the program in the fall of their senior year. Their primary focus is managing an interdisciplinary project with a local organization. Through training in project management and community engagement, participants hone leadership, critical thinking, and problem-solving skills—all tools needed to be a leader in any organization.

]]>
Presentation Wed, 02 Feb 2022 12:42:05 -0500 2022-02-02T17:30:00-05:00 2022-02-02T18:30:00-05:00 Off Campus Location Graham Sustainability Institute Presentation Graham Sustainability Scholars Info Session
Graham Sustainability Scholars Info Session (February 2, 2022 5:30pm) https://events.umich.edu/event/91870 91870-21683699@events.umich.edu Event Begins: Wednesday, February 2, 2022 5:30pm
Location: Off Campus Location
Organized By: Graham Sustainability Institute

Join us on Wednesday, February 2, at 5:30 p.m. for an information session on the Graham Scholars Program! This session will walk you through the process and what you can expect from the program, with time set aside to answer all your questions. Pre-register now or join using the Zoom link here.

Graham Sustainability Scholars form a tight-knit cohort supported, challenged, and inspired by each other, as well as by program partners and advisors.

Through rich co-curricular experiences, Graham Scholars learn to incorporate sustainability into the campus, their lifestyle, their discipline, and the broader community. They have access to professional development and other resources that are designed to enhance academic courses and help build resumes.

Program participants begin the in fall of their junior year and complete the program in the fall of their senior year. Their primary focus is managing an interdisciplinary project with a local organization. Through training in project management and community engagement, participants hone leadership, critical thinking, and problem-solving skills—all tools needed to be a leader in any organization.

]]>
Presentation Wed, 02 Feb 2022 12:42:05 -0500 2022-02-02T17:30:00-05:00 2022-02-02T18:30:00-05:00 Off Campus Location Graham Sustainability Institute Presentation Graham Sustainability Scholars Info Session
DCM&B Tools and Technology Seminar (February 3, 2022 12:00pm) https://events.umich.edu/event/89792 89792-21665801@events.umich.edu Event Begins: Thursday, February 3, 2022 12:00pm
Location: Off Campus Location
Organized By: DCMB Tools and Technology Seminar

The MinION is a recent-to-market handheld nanopore sequencer. It can be used to determine the whole genome of a target virus in a biological sample. Its Read Until feature allows us to skip sequencing a majority of non-target reads (DNA/RNA fragments), which constitutes more than 99% of all reads in a typical sample. However, it does not have any on-board computing, which significantly limits its portability. We analyze the performance of a Read Until metagenomic pipeline for detecting target viruses and identifying strain-specific mutations. We find new sources of performance bottlenecks (basecaller in classification of a read) that are not addressed by past genomics accelerators. We present SquiggleFilter, a novel hardware accelerated dynamic time warping (DTW) based filter that directly analyzes MinION’s raw squiggles and filters everything except target viral reads, thereby avoiding the expensive basecalling step. We show that our 14.3W 13.25mm2 accelerator has 274 × greater throughput and 3481 × lower latency than existing GPU-based solutions while consuming half the power, enabling Read Until for the next generation of nanopore sequencers.

SquiggleFilter: https://github.com/TimD1/SquiggleFilter
Associated Article: https://dl.acm.org/doi/10.1145/3466752.3480117

Speaker Bio: Hari Sadasivan is a PhD candidate in CSE focusing on hardware-software co-design for accelerating healthcare solutions like genome sequencing for microbiome abundance and precision medicine.

This presentation will be given remotely, with the livestream available via Zoom.

]]>
Presentation Thu, 20 Jan 2022 15:24:09 -0500 2022-02-03T12:00:00-05:00 2022-02-03T13:00:00-05:00 Off Campus Location DCMB Tools and Technology Seminar Presentation
Learning Health Systems: A Pathway to Sustainable Health Improvement (February 3, 2022 12:00pm) https://events.umich.edu/event/91725 91725-21682582@events.umich.edu Event Begins: Thursday, February 3, 2022 12:00pm
Location:
Organized By: Office of Research School of Dentistry

Charles Friedman is the Josiah Macy Jr. Professor of Medical Education and Chair of the Department of Learning Health Sciences at the University of Michigan Medical School. In recent years, he has focused his academic interests and activities on the concept of Learning Health Systems, and the socio-technical infrastructure required to sustain them. He is editor-in-chief of the open-access journal Learning Health Systems and co-chair of the movement to Mobilize Computable Biomedical Knowledge.

He was recently awarded an honorary doctorate by the University of Lucerne in Switzerland for his contributions to the science of Learning Health Systems.
Prior to coming to Michigan, Friedman held executive positions at the Office of the National Coordinator for Health IT (ONC) in the U.S. Department of Health and Human Services. Immediately prior to his work in the government, Dr. Friedman was Associate Vice Chancellor for Biomedical Informatics, and Founding Director of the Center for Biomedical Informatics at the University of Pittsburgh.

]]>
Presentation Mon, 31 Jan 2022 11:39:40 -0500 2022-02-03T12:00:00-05:00 2022-02-03T13:00:00-05:00 Office of Research School of Dentistry Presentation Charles P. Friedman, PhD
Targeting and monitoring focused ultrasound in the brain with MRI (February 3, 2022 3:30pm) https://events.umich.edu/event/91561 91561-21680566@events.umich.edu Event Begins: Thursday, February 3, 2022 3:30pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: Biomedical Engineering

Abstract:
Focused ultrasound is a noninvasive therapeutic modality in which ultrasound waves are focused to a point in the body to manipulate a target without affecting intervening tissue. Some of the most promising applications for focused ultrasound are in the brain, where it is FDA-approved for thermal ablation in movement disorders, and is also being explored for blood brain barrier opening and neuromodulation. MRI plays a critical role in targeting and monitoring the effects of transcranial focused ultrasound through its ability to image not only fine brain structures but also temperature and tissue displacement. In this talk I will present our efforts to overcome the myriad technical challenges associated with MRI guidance of transcranial focused ultrasound, including achieving volumetric coverage in brain thermometry, alleviating signal voids and artifacts caused by the presence of the transducer and its coupling media, and rapidly imaging tissue displacement to localize the focus and compensate acoustic aberrations caused by the skull. 

Bio:
Will Grissom is an Associate Professor of Biomedical Engineering at Vanderbilt University. He received his PhD from the University of Michigan in 2008, completed a postdoctoral fellowship at Stanford University in 2009, and worked as a Research Engineer at GE Global Research in Munich Germany until 2011. He then joined the Department of Biomedical Engineering and the Institute of Imaging Science at Vanderbilt University where he works on RF pulse design, image reconstruction, and RF coils for MRI from 47 mT to 7 T, and develops interventional MRI methods for guiding focused ultrasound and laser ablation and neuromodulation.

Organized by:
Dr. Brendon Baker,
Assistant Professor, Biomedical Engineering

Dr. David Nordsletten,
Associate Professor, Department of Biomedical Engineering and Cardiac Surgery

Zoom Link: https://umich.zoom.us/j/96508834308
Location: 1131 LBME, 1101 Beal Ave., Ann Arbor, MI 48109-2110

]]>
Workshop / Seminar Wed, 26 Jan 2022 15:42:01 -0500 2022-02-03T15:30:00-05:00 2022-02-03T16:30:00-05:00 Lurie Biomedical Engineering (formerly ATL) Biomedical Engineering Workshop / Seminar BME Seminar
EEB Virtual Thursday Seminar: Attract, wait it out, then do it yourself: a pollination contingency plan (February 3, 2022 4:00pm) https://events.umich.edu/event/85734 85734-21628573@events.umich.edu Event Begins: Thursday, February 3, 2022 4:00pm
Location: Off Campus Location
Organized By: Ecology and Evolutionary Biology

Our weekly seminar series featuring internal and external speakers in the field of ecology and evolutionary biology.

Abstract
Nearly 90 percent of flowering plants rely on pollinators for successful seed production. But what happens when pollinators fail? Selection may act to favor traits that make plants more attractive to pollinators. Or, plants could extend the amount of time they are able to export and import outcross pollen. And, if all else fails, the only option left may be to self-pollinate. First, I will present results from a study investigating spatial variation in pollinator-mediated selection on floral traits across wild populations of a biennial plant, Sabatia angularis. Next, I will present a series of experimental studies related to the evolution of floral longevity and its constraints. Finally, I will discuss how fragmentation and alteration of the landscape influence the extent to which plants must rely on self-pollination and shape population connectivity and genetic structure. This work has implications for understanding the forces that maintain variance within and among populations, the evolution of plant mating systems, and the fate of plant populations in a changing world.

Image credit: RB Spigler

]]>
Workshop / Seminar Thu, 20 Jan 2022 15:13:16 -0500 2022-02-03T16:00:00-05:00 2022-02-03T17:00:00-05:00 Off Campus Location Ecology and Evolutionary Biology Workshop / Seminar A bee on a pink flowering Sabatia plant
RISE Virtual Talking Circle (February 7, 2022 12:00pm) https://events.umich.edu/event/91172 91172-21677116@events.umich.edu Event Begins: Monday, February 7, 2022 12:00pm
Location: Off Campus Location
Organized By: RISE (Research. Innovation. Scholarship. Education.)

Education Innovations in the Laboratory Setting

Register via Eventbrite

]]>
Workshop / Seminar Tue, 18 Jan 2022 12:06:56 -0500 2022-02-07T12:00:00-05:00 2022-02-07T13:00:00-05:00 Off Campus Location RISE (Research. Innovation. Scholarship. Education.) Workshop / Seminar RISE Virtual Talking Circle
Dark Matter of the Human Genome (February 7, 2022 4:00pm) https://events.umich.edu/event/82493 82493-21110099@events.umich.edu Event Begins: Monday, February 7, 2022 4:00pm
Location: Off Campus Location
Organized By: Department of Chemistry

Analytical
Sarah Slavoff (Yale University)

]]>
Other Mon, 07 Feb 2022 18:15:27 -0500 2022-02-07T16:00:00-05:00 2022-02-07T17:30:00-05:00 Off Campus Location Department of Chemistry Other
MCDB Faculty Candidate > Phase Separation Control of Plant Immunity (February 8, 2022 11:45am) https://events.umich.edu/event/90361 90361-21670456@events.umich.edu Event Begins: Tuesday, February 8, 2022 11:45am
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Anthony Vecchiarelli

]]>
Workshop / Seminar Tue, 01 Feb 2022 11:29:58 -0500 2022-02-08T11:45:00-05:00 2022-02-08T12:45:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow MCDB initials and microscope cartoon on blue background
Long-term Air Pollution and Incident Dementia in U.S. (February 8, 2022 12:00pm) https://events.umich.edu/event/91240 91240-21677512@events.umich.edu Event Begins: Tuesday, February 8, 2022 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

REGISTRATION REQUIRED
https://umich.zoom.us/webinar/register/WN_d_LFab2xTmmTjHuJsfZLmg

Liuhua Shi, ScD, is Assistant Professor of Environmental Health in the Rollins School of Public Health at Emory University.

Dr. Shi's research focuses on employing massive datasets, including satellite-retrieved high resolution exposures and health data, to investigate how climate change and air pollution influence seniors' health.

More specifically, her research is focused on:
1. application of remote sensing in environmental exposure modeling (e.g., predicting high-resolution PM2.5, ozone, NO2, and temperature);
2. estimating the health consequences of exposure to air pollution and climate change;
3. estimating the link between climate change and air quality, and the mediated health impacts;
4. estimating the joint and independent health effects of air pollutant mixtures;
5. statistical modeling, e.g., causal modeling and big data approach.

]]>
Lecture / Discussion Wed, 19 Jan 2022 13:12:34 -0500 2022-02-08T12:00:00-05:00 2022-02-08T12:50:00-05:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Air pollution and dementia
Probing the Energetics of Single Membrane Proteins by Atomic Force Microscopy- Department of Biological Chemistry Faculty Candidate Seminar (February 8, 2022 12:00pm) https://events.umich.edu/event/90661 90661-21672082@events.umich.edu Event Begins: Tuesday, February 8, 2022 12:00pm
Location: Medical Science Unit I
Organized By: Biological Chemistry

Dr. David Jacobson, Postdoctoral Research Associate, University of Colorado at Boulder, will be presenting a faculty candidate seminar on Tuesday February 8th, 2022 at 12:00 noon in room 5330 MS I

]]>
Workshop / Seminar Fri, 07 Jan 2022 10:53:31 -0500 2022-02-08T12:00:00-05:00 2022-02-08T13:00:00-05:00 Medical Science Unit I Biological Chemistry Workshop / Seminar Jacobson
Modeling Enzymatic Reactivity with Copper Coordination Complexes (February 8, 2022 4:00pm) https://events.umich.edu/event/84411 84411-21623897@events.umich.edu Event Begins: Tuesday, February 8, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Synthetic models of enzyme intermediates play an important role in evaluating mechanistic hypotheses for critical biochemical reactions. In the first part of my talk, I will present the synthesis of dicopper coordination complexes as models to understand the reactivity of NO and NO2- at copper enzymes. We discovered that dicopper complex could activate NO or nitrite to generate a unique dicopper (II,III) oxo nitrosyl species [Cu2(μ-O)(μ-NO)]2+, which exhibits oxidative and nitrosative reactivity. This new mode of reactivity has important implications in how Nature employs NO and nitrite as electron acceptors for hydrocarbon oxidation. In the second part of my talk, I will discuss how synthetic models of monocopper oxygenases can be applied in the synthesis of pharmaceutically relevant organic molecules. Inspired by lytic polysaccharide monooxygenases, we develop a general Cu(II)/Cu(III) platform to activate simple nucleophiles (Nu) toward C-H functionalization. Oxidation of Cu(II)-Nu to Cu(III)-Nu endows the Nu moiety with hydrogen atom transfer and radical capture reactivity. Building on this platform, we have established a catalytic C-H fluorination method that selectively produces monofluorinated products in an undivided electrochemical cell at room temperature.

Shiyu Zhang (Ohio State University)

]]>
Other Tue, 08 Feb 2022 18:15:39 -0500 2022-02-08T16:00:00-05:00 2022-02-08T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
How the brain gets its sex (February 9, 2022 9:30am) https://events.umich.edu/event/90532 90532-21671498@events.umich.edu Event Begins: Wednesday, February 9, 2022 9:30am
Location: Off Campus Location
Organized By: Cell & Developmental Biology

Cell & Developmental Biology's 2022 Seminar Series is pleased to welcome E. Josie Clowney, Ph.D. to present on Wednesday, February 9th, 2022 in BSRB Kahn Auditorium.

E. Josie Clowney will be presenting an in-person and virtual seminar to discuss "How the brain gets its sex".

Hosted by: CDB and Jill Pearring

]]>
Lecture / Discussion Thu, 06 Jan 2022 09:06:58 -0500 2022-02-09T09:30:00-05:00 2022-02-09T10:30:00-05:00 Off Campus Location Cell & Developmental Biology Lecture / Discussion How the brain gets its sex
MCDB Faculty Candidate > Molecular logic and evolution of bitter taste in flies (February 10, 2022 11:45am) https://events.umich.edu/event/90360 90360-21670455@events.umich.edu Event Begins: Thursday, February 10, 2022 11:45am
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Postponed due to weather. New date: February 10
Host: Mohammed Akaaboune

]]>
Workshop / Seminar Tue, 01 Feb 2022 20:29:08 -0500 2022-02-10T11:45:00-05:00 2022-02-10T12:45:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow MCDB initials and microscope cartoon on blue background
Craniofacial Regeneration, Stem Cells, and Clinical Cell Therapy...Where are we now? (February 10, 2022 12:00pm) https://events.umich.edu/event/91853 91853-21683555@events.umich.edu Event Begins: Thursday, February 10, 2022 12:00pm
Location:
Organized By: Office of Research School of Dentistry

Major M. Ash Collegiate Professor of Periodontics
Department of Periodontics and Oral Medicine
University of Michigan

]]>
Presentation Wed, 02 Feb 2022 08:43:33 -0500 2022-02-10T12:00:00-05:00 2022-02-10T13:00:00-05:00 Office of Research School of Dentistry Presentation Darnell Kaigler, Jr., D.D.S, M.S., Ph.D.
High Sensitivity Microfluidic Measurements of Biomolecules (February 10, 2022 4:00pm) https://events.umich.edu/event/90950 90950-21675088@events.umich.edu Event Begins: Thursday, February 10, 2022 4:00pm
Location: Off Campus Location
Organized By: Department of Chemistry

Microfluidic analyses offer numerous benefits compared to traditional bioanalytical techniques. These miniaturized systems afford faster analysis times, require less sample volume, and can integrate sample preparation and analysis into a single platform. Our laboratory has harnessed these benefits to develop high sensitivity gel electrophoresis and digital PCR methods to measure diverse biological analytes including proteins, nucleic acids, small molecules, and cells. Our electrophoresis project utilizes thermally responsive polymers as a gel matrix. Temperature is adjusted to tune analytical performance and achieve preconcentration and separation of biomolecules and cells. Our digital PCR project integrates detection of proteins and nucleic acids. Target analytes are measured from individual biocomplexes with single-molecule sensitivity. The innovative analytical strategies developed in our laboratory enhance measurement capabilities to facilitate biological research.
Tom Linz (Wayne State University)

]]>
Other Thu, 10 Feb 2022 18:15:31 -0500 2022-02-10T16:00:00-05:00 2022-02-10T17:30:00-05:00 Off Campus Location Department of Chemistry Other
NO EEB Thursday Seminar today (February 10, 2022 4:00pm) https://events.umich.edu/event/86327 86327-21632728@events.umich.edu Event Begins: Thursday, February 10, 2022 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

There is NO SEMINAR today. See you next week!

Our weekly seminar series featuring internal and external speakers in the field of ecology and evolutionary biology.

]]>
Workshop / Seminar Tue, 25 Jan 2022 15:24:21 -0500 2022-02-10T16:00:00-05:00 2022-02-10T17:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Exterior of Biological Sciences Building with words EEB Thursday Seminar Series and UM EEB logo
MCDB Seminar> Genomes gone wild: Experimental evolution meets synthetic biology (February 11, 2022 12:00pm) https://events.umich.edu/event/90306 90306-21669862@events.umich.edu Event Begins: Friday, February 11, 2022 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Andrzej Wierzbicki

]]>
Workshop / Seminar Thu, 30 Dec 2021 18:04:12 -0500 2022-02-11T12:00:00-05:00 2022-02-11T13:00:00-05:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow MCDB initials and microscope drawing on blue background
RNA Faculty Candidate Seminar (February 14, 2022 4:00pm) https://events.umich.edu/event/89617 89617-21664565@events.umich.edu Event Begins: Monday, February 14, 2022 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

In-person/Hybrid seminar co-hosted by the Center for RNA Biomedicine, the Department of Biological Chemistry and the Department of Biophysics

Talk title: “Mechanisms of co-transcriptional ribonucleoprotein assembly”

Keywords: RNA, RNP, ribosome assembly, transcription, single-molecule fluorescence

If you are having trouble registering, please contact Martina Jerant at mjerant@umich.edu

]]>
Lecture / Discussion Thu, 02 Dec 2021 15:28:59 -0500 2022-02-14T16:00:00-05:00 2022-02-14T17:00:00-05:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion Margaret (Maggie) Rodgers, Johns Hopkins University
Complex Systems Seminar | Markov genealogy processes for exact phylodynamic inference (February 15, 2022 11:30am) https://events.umich.edu/event/92259 92259-21688751@events.umich.edu Event Begins: Tuesday, February 15, 2022 11:30am
Location: Weiser Hall
Organized By: The Center for the Study of Complex Systems

THIS WILL BE A HYBRID SEMINAR
WEISER HALL ROOM 747 (limit 30, mask required)
https://umich.zoom.us/j/96616169868 Passcode: CSCS

Abstract: We describe an approach to phylodynamics that unifies and extends existing likelihood-based methods for extracting information from virus genealogies to parameterize pathogen transmission models. While existing methods rely on approximations that are often violated in practice, our approach yields exact expressions for the likelihood. Specifically, we introduce a class of genealogy-valued Markov processes, induced by population-scale transmission models and show how these lead to a nonlinear filtering equation. The theory is mathematically rigorous and leads directly to computationally efficient inference algorithms.

]]>
Workshop / Seminar Mon, 14 Feb 2022 14:55:28 -0500 2022-02-15T11:30:00-05:00 2022-02-15T13:00:00-05:00 Weiser Hall The Center for the Study of Complex Systems Workshop / Seminar Aaron King
MCDB Faculty Candidate > The neural basis of sickness and immune-driven behaviors (February 15, 2022 11:45am) https://events.umich.edu/event/90362 90362-21670457@events.umich.edu Event Begins: Tuesday, February 15, 2022 11:45am
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Kwoon Wong

]]>
Workshop / Seminar Mon, 03 Jan 2022 17:27:45 -0500 2022-02-15T11:45:00-05:00 2022-02-15T12:45:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow MCDB initials and microscope cartoon on blue background
Biomolecular Condensates in Biology and Disease- Department of Biological Chemistry Faculty Candidate Seminar (February 15, 2022 12:00pm) https://events.umich.edu/event/90662 90662-21672083@events.umich.edu Event Begins: Tuesday, February 15, 2022 12:00pm
Location: Medical Science Unit I
Organized By: Biological Chemistry

Dr. Steven Boeynaems, Postdoctoral Researcher, Stanford University, will present a faculty candidate seminar on Tuesday February 15th, 2022 at 12:00 noon in room 5330 MS I

]]>
Workshop / Seminar Fri, 07 Jan 2022 10:58:24 -0500 2022-02-15T12:00:00-05:00 2022-02-15T13:00:00-05:00 Medical Science Unit I Biological Chemistry Workshop / Seminar Boeynaems
Whole genome sequencing in hematologic disease (February 16, 2022 9:30am) https://events.umich.edu/event/91439 91439-21679631@events.umich.edu Event Begins: Wednesday, February 16, 2022 9:30am
Location: Off Campus Location
Organized By: Cell & Developmental Biology

The department of Cell and Developmental Biology is pleased to present Dr. Patrick Gallagher for a virtual seminar on Wednesday, February 16th at 9:30 AM.

Entitled: Whole genome sequencing in hematologic disease

Hosted by: Doug Engel, Ph.d. and Rami Khoriaty, M.D.

]]>
Livestream / Virtual Mon, 24 Jan 2022 15:55:07 -0500 2022-02-16T09:30:00-05:00 2022-02-16T10:30:00-05:00 Off Campus Location Cell & Developmental Biology Livestream / Virtual Whole genome sequencing in hematologic disease
Engineering Folliculogenesis in a Biomimetic Matrix (February 16, 2022 3:00pm) https://events.umich.edu/event/92270 92270-21688760@events.umich.edu Event Begins: Wednesday, February 16, 2022 3:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Cancer survivorship has increased in recent decades due to advancements in anticancer treatments, yet cancer survivors continue to suffer from irreversible premature ovarian insufficiency and loss of fertility caused by radiation and chemotherapy. Restoration of reproductive function is uniquely challenging because women are born with a non-renewable reserve of ovarian follicles, the functional units of the ovary each carrying an oocyte (egg) and hormone producing somatic cells. Removal of ovarian tissue prior to gonadotoxic treatments and culture of isolated ovarian follicles is a safe fertility preservation option for pediatric and adult patients and does not require delays in treatment or hormonal stimulation. However, a high-yield, translational, and reproducible in vitro culture system that produces fertilizable eggs does not exist. Survival, growth, and maturation of early-stage primordial follicles, which constitute the majority of the follicular reserve, depend on bidirectional paracrine signaling through soluble cytokines and interactions with the extracellular matrix (ECM). To meet the needs of growing ovarian follicles we designed a biomimetic hydrogel for in vitro follicle culture that restores critical cell-cell and cell-matrix interactions for improved follicle outcomes. We hypothesized that a degradable poly(ethylene glycol) (PEG)-based matrix with tunable biophysical properties would (1) enable co-encapsulation of follicles and cells for paracrine signaling and (2) mimic the ECM functions of ovarian tissue.

First, we established that our degradable hydrogel could support co-culture of multiple cell types by co-encapsulating isolated murine primary follicles with adipose-derived stem cells (ADSCs) that secrete survival- and growth-promoting cytokines, compensating for the loss of native stromal cells. Bidirectional crosstalk between follicles and ADSCs promoted folliculogenesis and follicles doubled in size compared to follicles cultured without the ADSCs. Second, we incorporated ECM-sequestering peptides that retain cell-secreted ECM molecules, such as laminin, fibronectin, collagen type 1, and perlecan, thereby restoring cell-matrix interactions and improving growth factor binding. Secondary follicles cultured in PEG functionalized with peptides that bind basement membrane proteins exhibited greater than 93% survival, reached 340 µm in diameter, and achieved oocyte maturation rates of 84%. Lastly, we combined these approaches for restoring paracrine signaling and ECM function for culture of primordial follicles, the most immature and difficult to grow, but most abundant type of follicle in the ovary. We embedded hydrogels with ECM-sequestering dextran fibers to act as a scaffold for ECM deposition, better mimicking the fibrous structure of native ECM. ECM deposition and subsequent cell binding to fibers facilitated follicle and cell aggregation within the hydrogel matrix. Oocyte survival and growth was significantly improved in conditions which formed follicle-like aggregates surrounded by stroma, likely due to restoration of key cell-cell and cell-matrix interactions that promote follicle development.

In conclusion, we have engineered a fully synthetic hydrogel culture system that recapitulates the cellular and extracellular components of native ovarian tissue for improved follicle outcomes. This translational biomaterial is significant for guiding the development of a standardized in vitro culture system for maturation of human follicles and a safe fertility preservation option for cancer survivors unable to produce mature eggs. This biomimetic hydrogel also has broader impacts in the field of tissue engineering as it facilitates cell-driven reconstruction of their native microenvironments, providing a more comprehensive model for deciphering key mechanisms that drive regeneration in vitro.

Date: Wednesday, February 16, 2022
Time: 3:00 PM EST
Zoom: https://umich.zoom.us/j/99438979027 Passcode: GoFollicle
Chair: Dr. Ariella Shikanov

]]>
Presentation Fri, 11 Feb 2022 16:43:57 -0500 2022-02-16T15:00:00-05:00 2022-02-16T16:00:00-05:00 Off Campus Location Biomedical Engineering Presentation BME Defense Announcement
DCM&B Tools and Technology Seminar (February 17, 2022 12:00pm) https://events.umich.edu/event/89794 89794-21665803@events.umich.edu Event Begins: Thursday, February 17, 2022 12:00pm
Location: Off Campus Location
Organized By: DCMB Tools and Technology Seminar

I will describe a tool to learn representations of brain activity observed with functional magnetic resonance imaging. I will show how the tool works and how it can be extended. I will use some examples to demonstrate how to decode brain activity, connect brain to behavior, and use brain scans to identify individuals.

Tool Link: https://github.com/libilab/rsfMRI-VAE

This presentation will be remote only via Zoom

]]>
Presentation Wed, 16 Feb 2022 13:03:02 -0500 2022-02-17T12:00:00-05:00 2022-02-17T13:00:00-05:00 Off Campus Location DCMB Tools and Technology Seminar Presentation
Oral Health for All: Opportunities for Improvement and Understanding (February 17, 2022 1:00pm) https://events.umich.edu/event/91753 91753-21683050@events.umich.edu Event Begins: Thursday, February 17, 2022 1:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

Dr. Jennifer Webster-Cyriaque is the deputy director of National Institute of Dental and Craniofacial Research, National Institutes of Health. An accomplished clinician, researcher, and leader, Dr. Webster-Cyriaque had previously served as a faculty member at the University of North Carolina (UNC) schools of dentistry and medicine for more than two decades.

As a tenured full professor at UNC, Dr. Webster-Cyriaque also served as the attending on clinical service at the UNC Hospital’s dental clinic. While there, she led research into a potential etiologic agent for salivary gland disease in patients living with HIV, assessed the oral microbiome and its implications for cancer-causing viruses, and studied the impact of the oral microbiome and oral health on HIV outcomes.

In addition to her research, Dr. Webster-Cyriaque has held leadership roles as the chair/vice chair of the Oral HIV/AIDS Research Alliance, as research director at the National Dental Association Foundation, as director of postdoctoral CTSA training, along with multiple roles within the American Association for Dental, Oral, and Craniofacial Research and the International Association for Dental Research. Since 2004, she has led the UNC Malawi project and provided assistance in founding Malawi’s first dental school in 2019. Dr. Webster-Cyriaque earned her PhD in microbiology/immunology from the University of North Carolina-Chapel Hill in 1998, her DDS from SUNY Buffalo in 1992, and her BA in biology and interdisciplinary social science from SUNY Buffalo in 1988.

]]>
Presentation Tue, 01 Feb 2022 08:51:49 -0500 2022-02-17T13:00:00-05:00 2022-02-17T14:00:00-05:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Presentation Jennifer Webster-Cyriaque, DDS, PhD
EEB Thursday Seminar: Light and dark side of the force: Marine bivalve-algal photosymbiosis in light gradients (February 17, 2022 4:00pm) https://events.umich.edu/event/91562 91562-21680579@events.umich.edu Event Begins: Thursday, February 17, 2022 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Abstract
Photosymbiotic associations between heterotrophic hosts and photosynthetic algae play crucial roles in maintaining the trophic and structural integrity of marine ecosystems. This relationship has independently evolved in diverse eukaryotic lineages including sponges, corals, and bivalves. However, the basic biology of photosymbioses and their evolutionary implications are not well-understood. In this talk, I will use a representative photosymbiotic bivalve group to investigate the partners’ ecological and molecular adaptation to the photosymbiotic lifestyle. I will demonstrate that light availability play an important role in shaping the hosts’ morphological adaptation, energy update, symbiont composition, and genomic evolution.

]]>
Workshop / Seminar Thu, 17 Feb 2022 12:50:01 -0500 2022-02-17T16:00:00-05:00 2022-02-17T17:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Photosymbiotic cockle hosting microalgae
From Thermodynamics to Spin Trapping: Challenges across the Periodic Table (February 17, 2022 4:00pm) https://events.umich.edu/event/91341 91341-21678330@events.umich.edu Event Begins: Thursday, February 17, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Physical
Angela Wilson (Michigan State University)

]]>
Other Thu, 17 Feb 2022 18:15:29 -0500 2022-02-17T16:00:00-05:00 2022-02-17T17:30:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
U-M Structure Seminar: “The GRAFFENDOR (Graphene-based Affinity grid for the Endogenous Proteins) Grid" (February 18, 2022 10:00am) https://events.umich.edu/event/85437 85437-21626424@events.umich.edu Event Begins: Friday, February 18, 2022 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

Uhn-Soo Cho, Ph.D.
Associate Professor of Biological Chemistry, Medical School
University of Michigan

Hybrid: LSI Library and Zoom - https://umich.zoom.us/j/97763780708 (Password: structure)

]]>
Workshop / Seminar Mon, 24 Jan 2022 08:22:17 -0500 2022-02-18T10:00:00-05:00 2022-02-18T11:00:00-05:00 Life Sciences Institute U-M Structural Biology Workshop / Seminar U-M Structure
MCDB Seminar> 10 Years of Ferroptosis: Emerging Mechanisms and Therapeutic Applications (February 18, 2022 12:00pm) https://events.umich.edu/event/90307 90307-21669891@events.umich.edu Event Begins: Friday, February 18, 2022 12:00pm
Location: Off Campus Location
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Wanlu Du

Virtual: zoom link and passcode in Weekly Update or
email: mcdb.seminar.info@umich.edu

]]>
Workshop / Seminar Tue, 08 Feb 2022 14:01:24 -0500 2022-02-18T12:00:00-05:00 2022-02-18T13:00:00-05:00 Off Campus Location Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar illustration of cartoon of a molecule over a drawing of fetus with letters of DNA superimposed
SCSAP Monthly Seminar Series (February 21, 2022 1:00pm) https://events.umich.edu/event/92429 92429-21691399@events.umich.edu Event Begins: Monday, February 21, 2022 1:00pm
Location: Off Campus Location
Organized By: Single Cell Spatial Analysis Program (SCSAP)

Join us on Monday to hear about IsoPlexis’ product suite capabilities and how functional phenotyping is addressing urgent challenges central to unlocking the next stage of personalized cancer immunotherapies and vaccines related to immunological mechanisms in infectious disease. With single-cell proteomics barcoding and detection of a full range of cytokines (30+) per single-cell across thousands of single-cells, the IsoLight platform is showing the unique value of resolving the heterogeneity of a variety of immune cell types, elucidating key pre-clinical translational biomarkers to accelerate research and discovery.
JOIN US AT THE END OF THE TECH TALK TO LEARN ABOUT AN EXCITING GRANT PROGRAM SPONSORED BY THE UNIVERSITY OF MICHIGAN
SINGLE CELL SPATIAL ANALYSIS PROGRAM
Discussion topics include:
• Reveal the functional mechanism of immune activation in a novel agonist combination with adoptive cell therapy
• Uncover the role of TILs within Ipi/Nivo checkpoint combination and reveal the biological drivers of patient response
• Identify the unique polyfunctional monocyte cell types that drive tumor suppression
• Understand the functional differences of tumor antigen potency in bispecifics
• Identify functional immune mechanism CD8 T cell response for infectious diseases
• And other single-cell functional proteomics cases

]]>
Workshop / Seminar Wed, 16 Feb 2022 11:53:04 -0500 2022-02-21T13:00:00-05:00 2022-02-21T14:00:00-05:00 Off Campus Location Single Cell Spatial Analysis Program (SCSAP) Workshop / Seminar Isoplexis
MCDB Faculty Candidate > A genetically tractable jellyfish model for systems and evolutionary neuroscience (February 22, 2022 11:45am) https://events.umich.edu/event/90363 90363-21670458@events.umich.edu Event Begins: Tuesday, February 22, 2022 11:45am
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: E. Josie Clowney

]]>
Workshop / Seminar Tue, 01 Feb 2022 20:26:21 -0500 2022-02-22T11:45:00-05:00 2022-02-22T12:45:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow MCDB initials and microscope cartoon on blue background
Activities & Experiences of the Climate Hazards, Housing, & Health (CHHH) Community-Academic Partnership (February 22, 2022 12:00pm) https://events.umich.edu/event/92173 92173-21687628@events.umich.edu Event Begins: Tuesday, February 22, 2022 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Registration Required https://umich.zoom.us/webinar/register/WN_di5aDB3VTAa8U8sLrsOJtA

Zachary Rowe (Friends of Parkside, Detroit) and Carina Gronlund (Institute for Social Research, University of Michigan) will discuss issues of climate and health in Detroit.

Moderated by Marie O’Neill (School of Public Health, University of Michigan).

Recordings of the webinar series are posted to the M-LEEaD YouTube Channel https://www.youtube.com/channel/UC2MD-2fqFHTU3ODB8BHEDTg.

Organized by the Community Engagement Core and Integrated Health Sciences Core of the Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD).

]]>
Lecture / Discussion Wed, 09 Feb 2022 12:39:50 -0500 2022-02-22T12:00:00-05:00 2022-02-22T12:50:00-05:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion R&R: Residents and Researchers Tuesday Talks at 12 on environment, health, and community
How Cells Deal With Fat: Mechanisms of Lipid Storage and Mobilization- Department of Biological Chemistry Faculty Candidate Seminar (February 22, 2022 12:00pm) https://events.umich.edu/event/90663 90663-21672084@events.umich.edu Event Begins: Tuesday, February 22, 2022 12:00pm
Location: Medical Science Unit I
Organized By: Biological Chemistry

Dr. Jeeyun Chung, Postdoctoral Fellow, Harvard Medical School, will present a faculty candidate seminar on Tuesday February 22nd, 2022 at 12 noon in room 5330 MS I

]]>
Workshop / Seminar Fri, 07 Jan 2022 11:01:26 -0500 2022-02-22T12:00:00-05:00 2022-02-22T13:00:00-05:00 Medical Science Unit I Biological Chemistry Workshop / Seminar Chung
Activity-based chemical probes for RNA modifying enzymes (February 22, 2022 4:00pm) https://events.umich.edu/event/88867 88867-21658706@events.umich.edu Event Begins: Tuesday, February 22, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Epitranscriptomic RNA modifications can regulate RNA activity, however there remains a major gap in our understanding of the scope of RNA chemistry present in biological systems, the enzymes responsible for regulating modification levels, and the ultimate function of these modifications in biological processes. To address this gap, our group has developed RNA-mediated activity-based protein profiling (RNABPP), a chemoproteomic strategy relying upon metabolic RNA labeling with modified nucleoside probes, RNA-protein enrichment, and quantitative proteomics. This lecture will discuss the application of RNABPP with fluoropyrimidine nucleosides in human cells in order to profile diverse families of RNA modifying enzymes including m5C and m5U methyltranferases, as well as dihydrouridine synthase (DUS) enzymes. Time allowing, I will also discuss new developments in RNA metabolic labeling technology.







Ralph Kleiner (Princeton University)

]]>
Other Tue, 22 Feb 2022 18:15:39 -0500 2022-02-22T16:00:00-05:00 2022-02-22T17:15:00-05:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Functional MRI 2021-22 Speaker Series with Richard Betzel, Ph.D. (February 22, 2022 4:00pm) https://events.umich.edu/event/91424 91424-21679561@events.umich.edu Event Begins: Tuesday, February 22, 2022 4:00pm
Location: Off Campus Location
Organized By: Functional MRI Lab

Abstract:

Network neuroscience is built atop a network model in which cells, populations, and regions are linked to one another via anatomical or functional connections. Historically, this model has been approached from a node-centric perspective, emphasizing features of neural elements: the number of connections they make, their centrality, module affiliation, etc. However, brain networks can also be examined from an edge-centric perspective that explicitly focuses on properties of connections: their material and metabolic costs, the generative processes that govern connection formation and their dynamics across time. In this talk, I will present results from several recent papers and highlight findings and advantages of edge-centric network perspectives compared with traditional node-centric network representations.

This will be a virtual event, you can attend via Zoom:
https://umich.zoom.us/j/95541670960
passcode: 207196

]]>
Lecture / Discussion Mon, 24 Jan 2022 12:13:17 -0500 2022-02-22T16:00:00-05:00 2022-02-22T17:30:00-05:00 Off Campus Location Functional MRI Lab Lecture / Discussion Richard Betzel, Ph.D.
Weekly Seminar for DCMB / CCMB (February 23, 2022 4:00pm) https://events.umich.edu/event/92060 92060-21686457@events.umich.edu Event Begins: Wednesday, February 23, 2022 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

In the Peixoto lab we use genomic approaches to understand gene expression and its epigenetic regulation in response to learning and sleep deprivation, and its alteration in autism spectrum disorders. This requires combining behavioral paradigms in mice, molecular biology and the analysis of high-throughput data in the brain in vivo. It also requires using the right data analysis tools to be able to capture the effect of learning or sleep in the context of an ever-active brain. In this talk we will discuss the effects of learning on chromatin accessibility and the effects of sleep loss in gene expression, with an emphasis on how data analysis influences our ability to detect novel and reproducible biology.

Short bio:

Lucia Peixoto received her bachelor’s degree in Biochemistry from the Universidad de la Republica in her native Uruguay in 2002. She subsequently earned her Ph.D. at The University of Pennsylvania under the mentorship of Dr. David S. Roos, using genomic and computational biology approaches to understand host-pathogen interactions. She completed her postdoctoral training in Neuroscience with Dr. Ted Abel at The University of Pennsylvania in 2015. During her fellowship, she was also a trainee at the Training Program in Neurodevelopmental disabilities at the Children’s Hospital of Philadelphia. As a trainee at CHOP, she completed a clinical internship at the Center for Autism Research under the supervision of Dr. Robert Schultz. She became an Assistant Professor at Washington State University in 2015 and has since been recognized with a K01 Early Career Faculty award from NIH/NINDS and a pilot award from the Simons Foundation Autism Research Initiative. She is also a member of the board of directors of the International Society of computational biology (ISCB) and cochair the Equity, Diversity and Inclusion committee of ISCB. Her lab uses behavior, electrophysiology, molecular biology and genomic approaches to understand how sleep and learning modulate transcription and how this may be altered in Autism Spectrum Disorders.

Zoom livestream link: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

]]>
Workshop / Seminar Mon, 07 Feb 2022 14:54:44 -0500 2022-02-23T16:00:00-05:00 2022-02-23T17:00:00-05:00 Off Campus Location DCMB Seminar Series Workshop / Seminar
Synthesis and Photophysics of First-Row Transition Metal Oxide Semiconductor Nanomaterials (February 24, 2022 12:00am) https://events.umich.edu/event/91600 91600-21681018@events.umich.edu Event Begins: Thursday, February 24, 2022 12:00am
Location: Off Campus Location
Organized By: Department of Chemistry

Metal oxide nanomaterials based on first-row transition metals are particularly attractive for applications in renewable energy technologies because (i) they absorb visible light, (ii) they are thermodynamically capable of performing desired photoredox chemistry, such as water oxidation and reduction of protons or carbon dioxide, and (iii) they are composed of inexpensive, earth-abundant, nontoxic elements. Complete synthetic control of the size, shape, and crystal structure of first-row transition metal oxide nanomaterials combined with a thorough understanding of their electrochemical and photophysical behavior is required to optimize their function in photocatalytic applications. This talk focuses on recent results from two ongoing areas in our group. The first area investigates the role of organic ligands, solvent, and precursor chemistry in controlling the size, shape, composition, and crystal phase of first-row transition metal oxide nanocrystals synthesized at elevated pressure using solvothermal methods. The second project combines thermal difference and resonance Raman spectroscopy with DFT calculations to explore the dynamics and electronic structure of photoexcited states of nanostructured thin films of alpha-Fe2O3 (hematite). These data indicate that polarons (quasiparticles that comprise a charge-carrier self-trapped in a potential well formed by nuclear displacements of the surrounding lattice) form directly upon photoexcitation of a thermally activated lattice. This newly recognized mechanism of photoinduced polaron formation has significant implications for the use of hematite in light-conversion technologies such as photoelectrochemical water oxidation.
Kathryn Knowles (University of Rochester)

]]>
Other Thu, 24 Feb 2022 18:15:22 -0500 2022-02-24T00:00:00-05:00 2022-02-24T00:00:00-05:00 Off Campus Location Department of Chemistry Other
DCM&B Tools and Technology Seminar (February 24, 2022 12:00pm) https://events.umich.edu/event/89807 89807-21665816@events.umich.edu Event Begins: Thursday, February 24, 2022 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

Networks are a valuable tool for quantifying a variety of biological relationships, from gene co-expression to cellular proximity. Comparison of these networks can thus shed light on how biological systems vary in different settings, such as across treatment groups or disease states. In this presentation, I present a collection of tools for quantifying and visualizing differences across a set of networks.

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

]]>
Presentation Mon, 06 Dec 2021 18:33:03 -0500 2022-02-24T12:00:00-05:00 2022-02-24T13:00:00-05:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
LHS Collaboratory (February 24, 2022 12:00pm) https://events.umich.edu/event/90079 90079-21667713@events.umich.edu Event Begins: Thursday, February 24, 2022 12:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

The session will describe the landscape history, current status, and future of federated health data networks that are used to support a Learning Health System. Dr. Brown will describe the creation, infrastructure, operation, and uses of several networks from the perspective of a network coordinating center. Dr. Harris will describe insights from participating in multiple networks as a network partner, including infrastructure, governance, and operational lessons learned.

Presenters:
Jeffrey Brown, PhD
Dr. Brown is the inventor of PopMedNet, an open-source software platform that facilitates creation and operation of distributed health data networks.

Marcelline Harris, Ph.D., RN, FACMI
Associate Professor Emerita
Department of Systems, Populations and Leadership
University of Michigan School of Nursing

]]>
Lecture / Discussion Sat, 29 Jan 2022 11:26:41 -0500 2022-02-24T12:00:00-05:00 2022-02-24T13:30:00-05:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion Collaboratory logo
EEB Thursday Seminar: Using the past to predict the future: Holocene species extinctions help set wildlife conservation priorities for a heating planet (February 24, 2022 4:00pm) https://events.umich.edu/event/92522 92522-21692012@events.umich.edu Event Begins: Thursday, February 24, 2022 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Our weekly seminar series featuring internal and external speakers in the field of ecology and evolutionary biology.

Image: An Aegean wall lizard (Podarcis erhardii)

]]>
Workshop / Seminar Tue, 22 Feb 2022 09:06:27 -0500 2022-02-24T16:00:00-05:00 2022-02-24T17:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar An Aegean wall lizard (Podarcis erhardii) sunning on a rock with water in the background
U-M Structure Seminar: "Machine learning in cryo-EM" (February 25, 2022 10:00am) https://events.umich.edu/event/85438 85438-21626425@events.umich.edu Event Begins: Friday, February 25, 2022 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

Yilai Li, Ph.D.
Postdoctoral Research Fellow
University of Michigan, Cianfrocco Lab

This seminar is only open to UM researchers.

]]>
Workshop / Seminar Wed, 02 Feb 2022 10:48:48 -0500 2022-02-25T10:00:00-05:00 2022-02-25T11:00:00-05:00 Life Sciences Institute U-M Structural Biology Workshop / Seminar U-M Structure
From R&D to the Patient: (February 25, 2022 10:30am) https://events.umich.edu/event/91861 91861-21683567@events.umich.edu Event Begins: Friday, February 25, 2022 10:30am
Location: Off Campus Location
Organized By: William Davidson Institute

Moving health products from the research and development stage to the clinic is a long and costly process that involves many actors, particularly in low- and middle-income countries (LMICs). In these markets, global organizations such as the Bill & Melinda Gates Foundation, the Global Fund to Fight AIDS, TB and Malaria, and Gavi play a significant role in moving health products through the process. These organizations influence market behavior at the research and development, manufacturing, procurement and delivery stages with the hopes of increasing access to life saving health products to patients in LMICs. Their efforts have been effective. For example, over the last 20 years the number of deaths caused by AIDS, tuberculosis and malaria has been reduced by 46% in countries where Global Fund works. Gavi has helped immunize 760 million children in the last 21 years, preventing over 13 million deaths worldwide. These are significant achievements, but are there opportunities to better engage some of the other actors in this space, particularly those from the private sector? We will explore this idea through discussion with the panelists representing the Gates Foundation, the Global Fund and representing the Gates Foundation, the RBM Partnership to End Malaria, and The Global Fund to Fight AIDS, TB & Malaria.

]]>
Livestream / Virtual Wed, 02 Feb 2022 11:42:32 -0500 2022-02-25T10:30:00-05:00 2022-02-25T12:00:00-05:00 Off Campus Location William Davidson Institute Livestream / Virtual From R&D to the Patient: Changing the Role of Business in Global Health
BIBC Pharmaceutical Sciences Faculty Candidate (February 25, 2022 12:00pm) https://events.umich.edu/event/92617 92617-21693694@events.umich.edu Event Begins: Friday, February 25, 2022 12:00pm
Location:
Organized By: BioInnovations in Brain Cancer

Hybrid Research seminar for the BioInnovations in Brain Cancer Faculty Candidate, Julian Zhu, PhD. This appointment is through the Pharmaceutical Sciences department and will be held at NCRC B10, Research Auditorium and over Zoom (registration required).

]]>
Conference / Symposium Mon, 21 Feb 2022 10:29:42 -0500 2022-02-25T12:00:00-05:00 2022-02-25T13:00:00-05:00 BioInnovations in Brain Cancer Conference / Symposium Dr. Julian Zhu - Research Seminar Flyer
MCDB Seminar> Chromatin, transcription regulation in ethylene response and drought stress (February 25, 2022 12:00pm) https://events.umich.edu/event/90308 90308-21669892@events.umich.edu Event Begins: Friday, February 25, 2022 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Ming Li

]]>
Workshop / Seminar Tue, 08 Feb 2022 13:56:25 -0500 2022-02-25T12:00:00-05:00 2022-02-25T13:00:00-05:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow MCDB initials and microscope cartoon on blue background
RNA Seminar: “Translating the cancer genome: dark matter proteins” (February 28, 2022 4:00pm) https://events.umich.edu/event/92357 92357-21690330@events.umich.edu Event Begins: Monday, February 28, 2022 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

In-person/Hybrid seminar co-hosted by The Center for RNA Biomedicine, Department of Computational Medicine & Bioinformatics, and Department of Pediatric Oncology

Talk title: “Translating the cancer genome: dark matter proteins”

Keywords: cancer, ribosome profiling, functional genomics, gene discovery.

Abstract: Although genomic analyses predict many non-canonical open reading frames (ORFs) in the human genome, it is unclear whether they encode biologically active proteins in diseases such as cancer. Here, we have developed functional genomics platforms to systematically interrogate non-canonical ORFs identified in ribosome profiling data. Using CRISPR loss-of-function screens in numerous human cancer models, we define the frequency with which ORFs contribute to cell essentiality phenotypes. We further constructed large-scale ORF plasmid libraries to assess their capacity to encode a protein and induce cancer cell transcriptional changes. We pursued focused investigation of several uncharacterized protein-coding loci, defining roles for the lncRNA-ORF GREP1 in breast cancer and the ASNSD1 upstream ORF (uORF) in medulloblastoma. Lastly, we have assembled a pathway to bring such ORF candidates into the mainstream of biological research via an international consortium of gene database stakeholders. Together, this work establishes non-canonical ORFs as critical mediators of cancer cell biology, suggests their potential promise as therapeutic targets in cancer, and outlines a path forward for dissemination of these ORFs amongst the global research community.

If you are having trouble registering, please contact Martina Jerant at mjerant@umich.edu

]]>
Lecture / Discussion Mon, 14 Feb 2022 16:09:35 -0500 2022-02-28T16:00:00-05:00 2022-02-28T17:00:00-05:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion John Prensner, MD, PhD
MCDB Faculty Candidate > Neuronal Activity - Dependent DNA Repair in Plasticity and Aging (March 1, 2022 11:45am) https://events.umich.edu/event/90405 90405-21670710@events.umich.edu Event Begins: Tuesday, March 1, 2022 11:45am
Location: Chemistry Dow Lab
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Sara Aton

]]>
Workshop / Seminar Tue, 08 Feb 2022 13:48:39 -0500 2022-03-01T11:45:00-05:00 2022-03-01T12:45:00-05:00 Chemistry Dow Lab Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow MCDB initials and microscope cartoon on blue background
BIBC Pharmaceutical Sciences Faculty Candidate (March 2, 2022 11:00am) https://events.umich.edu/event/92618 92618-21693695@events.umich.edu Event Begins: Wednesday, March 2, 2022 11:00am
Location:
Organized By: BioInnovations in Brain Cancer

Hybrid Research seminar for the BioInnovations in Brain Cancer Faculty Candidate, Yizhou Dong, PhD. This appointment is through the Pharmaceutical Sciences department and will be held at NCRC B10, Research Auditorium and over Zoom (registration required).

]]>
Conference / Symposium Mon, 28 Feb 2022 11:07:22 -0500 2022-03-02T11:00:00-05:00 2022-03-02T12:00:00-05:00 BioInnovations in Brain Cancer Conference / Symposium Dr. Yizhou Dong - Research Seminar Flyer
DCM&B Tools and Technology Seminar (March 3, 2022 12:00pm) https://events.umich.edu/event/92260 92260-21688747@events.umich.edu Event Begins: Thursday, March 3, 2022 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

]]>
Presentation Fri, 11 Feb 2022 15:02:48 -0500 2022-03-03T12:00:00-05:00 2022-03-03T13:00:00-05:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
EMERSE Meeting Series (March 3, 2022 2:00pm) https://events.umich.edu/event/91855 91855-21683557@events.umich.edu Event Begins: Thursday, March 3, 2022 2:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Unstructured clinical data, such as clinical notes and reports, along with the computational infrastructure and tools, have seen an increasing demand from the research community in the last years, mostly fueled by recent advances in statistical and machine-learning approaches to data insight. We are meeting this demand with the Information Commons – a research data platform that hosts and provides direct access to de-identified data, advanced analytics tools, and computational environments for our research community. 

While we are realizing access to de-identified electronic health records, images, omics and biobank data, this session highlights the progress made to provide more than 110 million de-identified notes to the research community. We developed and operationalized a fully automatic de-identification algorithm and implemented EMERSE, a user-friendly tool for non-programmatic access and sophisticated textual searches on the de-identified clinical notes.   

As of December 2021 Our de-identification algorithm and our clinical notes are certified de-identified and are currently available for the UCSF researchers with IRD. The presentation covers the entire pipeline from data extraction to publication and data access focusing on the secured computational infrastructure. Furthermore, we discuss the rigorous evaluation techniques to ensure the quality of the deidentification process and the resulting data according to HIPAA and UCSF Security and Privacy protection requirements. Lastly, we showcase highlights from our research collaborations enabled by this new resource of machine-redacted, unstructured clinical notes linked with de-identified structured EHR data using EMERSE and their impact on the research community.

Speakers:
Eric Meeks
Chief Technology Officer, CTSI @University of California, San Francisco

Lakshmi Radhakrishnan
Data Scientist @University of California, San Francisco

]]>
Lecture / Discussion Wed, 02 Feb 2022 09:28:30 -0500 2022-03-03T14:00:00-05:00 2022-03-03T15:00:00-05:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion EMERSE logo
NO EEB Thursday Seminar today (March 3, 2022 4:00pm) https://events.umich.edu/event/92799 92799-21695815@events.umich.edu Event Begins: Thursday, March 3, 2022 4:00pm
Location:
Organized By: Ecology and Evolutionary Biology

See you next week!

Image: Teresa Pegan

]]>
Workshop / Seminar Fri, 25 Feb 2022 12:49:28 -0500 2022-03-03T16:00:00-05:00 2022-03-03T17:00:00-05:00 Ecology and Evolutionary Biology Workshop / Seminar Chickadee on a snowy branch.
U-M Structure Seminar: "Defining Human Cytochrome P450 8B1 Structure and Function: Supporting Drug Design for Nonalcoholic Fatty Liver Disease and Diabetes" (March 4, 2022 10:00am) https://events.umich.edu/event/85439 85439-21626426@events.umich.edu Event Begins: Friday, March 4, 2022 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

Jinghan Liu
Graduate Student
University of Michigan, Emily Scott Lab

Hybrid: LSI Library and Zoom - https://umich.zoom.us/j/97763780708 (Password: structure)

]]>
Workshop / Seminar Thu, 10 Feb 2022 12:49:21 -0500 2022-03-04T10:00:00-05:00 2022-03-04T11:00:00-05:00 Life Sciences Institute U-M Structural Biology Workshop / Seminar U-M Structure
BIBC Neurosurgery Faculty Candidate (March 7, 2022 3:00pm) https://events.umich.edu/event/92826 92826-21697072@events.umich.edu Event Begins: Monday, March 7, 2022 3:00pm
Location: Medical Science Unit II
Organized By: BioInnovations in Brain Cancer

The BioInnovations in Brain Cancer Program is recruiting tenure track faculty positions at all levels. On March 7-8, the Neurosurgery department will be hosting Dr. Toshiro Hara as a candidate for one of these positions, and his research seminar is available to view either in person or over Zoom.

]]>
Conference / Symposium Mon, 28 Feb 2022 11:06:25 -0500 2022-03-07T15:00:00-05:00 2022-03-07T16:00:00-05:00 Medical Science Unit II BioInnovations in Brain Cancer Conference / Symposium Dr. Toshiro Hara - Research Seminar Flyer
Complex Systems Seminar: Promoting the use of agent-based modeling in scientific inquiry: a Learning Sciences approach (March 8, 2022 11:30am) https://events.umich.edu/event/92858 92858-21697300@events.umich.edu Event Begins: Tuesday, March 8, 2022 11:30am
Location: Off Campus Location
Organized By: The Center for the Study of Complex Systems

Virtual Seminar
https://umich.zoom.us/j/96616169868
Password: CSCS (all caps)

Abstract: Agent-based modeling provides a powerful computational infrastructure to construct dynamic representations of scientific phenomena that can augment analytical models in unique and meaningful ways. However, although it is used extensively in the field of complex systems and embraced by social scientists, only a handful of researchers in natural sciences incorporate agent-based modeling components into their theoretical investigations. In this talk, I will present findings from two of my prior studies on reconstructing existing theoretical models through agent-based modeling and I will argue that the tools and methods of Learning Sciences can help us cultivate productive ways of augmenting existing theoretical studies with agent-based components in a manner that is commensurate with scientists’ ways of thinking, which would in turn accelerate adoption of the complexity lens by more and more natural scientists.

]]>
Workshop / Seminar Tue, 08 Mar 2022 11:04:29 -0500 2022-03-08T11:30:00-05:00 2022-03-08T13:00:00-05:00 Off Campus Location The Center for the Study of Complex Systems Workshop / Seminar Ümit Aslan
Finding Funding: Identifying Opportunities & Scoping the Grants Landscape (March 8, 2022 12:00pm) https://events.umich.edu/event/91560 91560-21680564@events.umich.edu Event Begins: Tuesday, March 8, 2022 12:00pm
Location: Off Campus Location
Organized By: OVPR Office of Research Development

Hosted by U-M Research Development & Proposal Services, library experts Judy Smith and Paul Barrow will present a workshop to help investigators at all levels use online tools to be proactive in identifying federal, state, and foundation research funding. Topics will include efficient searching of funding databases and setting up funding alerts through examining the special features of Foundation Directory Online and Pivot. The workshop also will direct researchers to units at U-M that will support their grantseeking endeavors.

]]>
Livestream / Virtual Wed, 26 Jan 2022 15:26:33 -0500 2022-03-08T12:00:00-05:00 2022-03-08T13:00:00-05:00 Off Campus Location OVPR Office of Research Development Livestream / Virtual Finding funding
"Using Epigenome Actuation to Advance Epigenetic Therapy for Triple Negative Breast Cancer" (March 8, 2022 4:00pm) https://events.umich.edu/event/91191 91191-21677135@events.umich.edu Event Begins: Tuesday, March 8, 2022 4:00pm
Location: Off Campus Location
Organized By: Center for Cell Plasticity and Organ Design

The Center for Cell Plasticity and Organ Design is proud to present the following seminar with guest speaker Karmella A. Haynes, PhD. Dr. Haynes is an Assistant Professor of Biomedical Engineering at Emory University.

Her talk is entitled, "Using Epigenome Actuation to Advance Epigenetic Therapy for Triple Negative Breast Cancer".

Faculty Host: Laura Buttitta, PhD, LSA-Molecular, Cellular, & Developmental Biology

For more information, please email Organogenesis@umich.edu(link

]]>
Lecture / Discussion Tue, 18 Jan 2022 14:08:23 -0500 2022-03-08T16:00:00-05:00 2022-03-08T17:00:00-05:00 Off Campus Location Center for Cell Plasticity and Organ Design Lecture / Discussion Flyer for the Event
Exploration of Photoresponsive Materials (March 8, 2022 4:00pm) https://events.umich.edu/event/91344 91344-21678333@events.umich.edu Event Begins: Tuesday, March 8, 2022 4:00pm
Location: Off Campus Location
Organized By: Department of Chemistry

Photons have multiple enabling advantages to control stimuli-responsive materials. In this seminar, I will discuss our groups effort to design and develop a new class of negative photochromic molecules termed DASA, their incorporation into materials and subsequent effort to unlock their potential to convert light directly into mechanical work.




Javier Read de Alaniz (UC Santa Barbara)

]]>
Other Tue, 08 Mar 2022 18:15:27 -0500 2022-03-08T16:00:00-05:00 2022-03-08T17:30:00-05:00 Off Campus Location Department of Chemistry Other
Making TSCA Work: Demystifying the Risk Assessment Process (March 8, 2022 4:00pm) https://events.umich.edu/event/92216 92216-21688196@events.umich.edu Event Begins: Tuesday, March 8, 2022 4:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

REGISTRATION REQUIRED
https://umich.zoom.us/webinar/register/WN_K4BCE3rXSIuGYHsJ3n5LFw

The University of Michigan M-LEEaD Center is co-sponsoring a virtual event to discuss the bipartisan legislation called the Frank R. Lautenberg Chemical Safety for the 21st Century Act. This reform law was designed to modernize the Toxic Substances Control Act (TSCA) and U.S. industrial chemical policy to promote health, but has it lived up to its promise?

Toxic chemicals can harm our health as these substances are present in everyday products (e.g., cleaning products, cookware, housing and infrastructure materials, bedding, toys). Unlike pharmaceuticals, industrial and commercial chemicals are rarely tested for safety before they reach the U.S. market. However, amended TSCA gave the U.S. Environmental Protection Agency new authorities to require manufacturers provide the data needed for risk assessments. People expect the outcomes of implementing our environmental laws to be equitable health protection for the public from environmental harms. Yet, key components of risk evaluations seem complex and thus inaccessible to the public. Our goal is to demystify the process of assessing the science to move toward evidence-based safeguards communities want for public health.

Our virtual event will examine key issues from a series of recent scientific workshops. We will present a case study of applying the principles to treating cancer and non-cancer health effects in similar manners in the risk assessment for the chemical perchloroethylene (PCE). We will explore the use of probabilistic assessments in TSCA risk evaluations. The amended TSCA gave the U.S. Environmental Protection Agency new requirements and authorities. The public health impact points to the need for the U.S. EPA to fully use its new powers to evaluate all risks from hazardous chemicals and set policies which protect health and are accountable to high-risk communities. Preventive actions are urgently needed.

Speakers and discussants include:
* Regina Strong (Office of the Environmental Justice Public Advocate for the Michigan Department of Environment, Great Lakes and Energy (EGLE));
* Wilma Subra (Technical Director, Louisiana Environmental Action Network);
* Wendy Heiger-Bernays, PhD (Clinical Professor, Department of Environmental Health, Boston University);
* Gary Ginsberg, PhD (New York Dept of Health, Center for Environmental Health (CEH));
* Chanese Forté, PhD, MPH (Assistant Research Scientist, University of California, San Francisco, Program on Reproductive Health and the Environment);
* Greylin Nielsen, MPH (Doctoral student, Department of Environmental Health, Boston University School of Public Health).

REGISTRATION REQUIRED
https://umich.zoom.us/webinar/register/WN_K4BCE3rXSIuGYHsJ3n5LFw

]]>
Workshop / Seminar Mon, 07 Mar 2022 12:42:08 -0500 2022-03-08T16:00:00-05:00 2022-03-08T18:00:00-05:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Workshop / Seminar Making TSCA Work
Potential and Pitfalls of Polygenic Scores For Social Demographic Research (March 9, 2022 2:00pm) https://events.umich.edu/event/85344 85344-21626257@events.umich.edu Event Begins: Wednesday, March 9, 2022 2:00pm
Location: Off Campus Location
Organized By: Institute for Social Research

This webinar series on the Chitwan Valley Family Study (CVFS) is about global and comparative population research. Sessions include measuring mental health, Covid-19, linking data, genetics, & migrant data.

Webinar 12: Potential and Pitfalls of Polygenic Scores For Social Demographic Research
Wednesday, March 9, 2022
2-3pm EDT
Presenter: Colter Mitchell

This webinar will provide an overview of the methodology around the construction of polygenic scores and their applications in demographic research. There will be a Q&A session after the presentation.

The webinar will be hosted using Zoom. Registration is required to attend the webinar. Support provided by NICHD (R25 HD101358).

Registration is required for this event: https://umich.zoom.us/meeting/register/tJwqde2tpzovGt21ffMiK7ndNIVGOovGaCqi

]]>
Presentation Tue, 17 Aug 2021 15:01:18 -0400 2022-03-09T14:00:00-05:00 2022-03-09T15:00:00-05:00 Off Campus Location Institute for Social Research Presentation Nepal mountains
BioArtography - Call for Images (March 10, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701901@events.umich.edu Event Begins: Thursday, March 10, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-10T00:00:00-05:00 2022-03-10T23:59:00-05:00 BioArtography Other U-M BioArtography
DCM&B Tools and Technology Seminar (March 10, 2022 12:00pm) https://events.umich.edu/event/89809 89809-21665887@events.umich.edu Event Begins: Thursday, March 10, 2022 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

]]>
Presentation Tue, 07 Dec 2021 09:00:37 -0500 2022-03-10T12:00:00-05:00 2022-03-10T13:00:00-05:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
EEB Thursday Seminar: Predicting behavior in a changing world: sensory resilience and climate change (March 10, 2022 4:00pm) https://events.umich.edu/event/85736 85736-21628575@events.umich.edu Event Begins: Thursday, March 10, 2022 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Our weekly seminar series featuring internal and external speakers in the field of ecology and evolutionary biology.

Abstract
Whether organisms survive climate change depends on their abilities to sense environmental shifts and to respond accordingly. We can use evolutionary inferences about historical changes in sensory behavior to predict future resilience to climate change. Here, I illustrate this process with our own studies of Sceloporus lizard communication and wild zebrafish social behavior.

This event will be in person and livestreamed (see link this page).

Image: Stephanie M. Campos

]]>
Workshop / Seminar Fri, 04 Mar 2022 16:16:29 -0500 2022-03-10T16:00:00-05:00 2022-03-10T17:00:00-05:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Sceloporus lizard on a rock
BioArtography - Call for Images (March 11, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701902@events.umich.edu Event Begins: Friday, March 11, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-11T00:00:00-05:00 2022-03-11T23:59:00-05:00 BioArtography Other U-M BioArtography
Data Science in Health Disparities Research Symposium (March 11, 2022 9:00am) https://events.umich.edu/event/91976 91976-21684826@events.umich.edu Event Begins: Friday, March 11, 2022 9:00am
Location: Palmer Commons
Organized By: DCMB Seminar Series

Additional speakers on the topics of:

How data science can be used to understand racial health disparities

How data science with biased data exacerbates health disparities

Lunch and discussion sessions following the talks.

]]>
Workshop / Seminar Mon, 07 Feb 2022 10:37:38 -0500 2022-03-11T09:00:00-05:00 2022-03-11T15:00:00-05:00 Palmer Commons DCMB Seminar Series Workshop / Seminar
MCDB Seminar> Regulation of miRNA biogenesis in Arabidopsis (March 11, 2022 12:00pm) https://events.umich.edu/event/90408 90408-21670714@events.umich.edu Event Begins: Friday, March 11, 2022 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Andrzej Wierzbicki

]]>
Workshop / Seminar Tue, 08 Feb 2022 15:39:53 -0500 2022-03-11T12:00:00-05:00 2022-03-11T13:00:00-05:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar drawing of Brahma, Hindi god with several arms and faces and mRNA
Movement on Demand: Pharmacological and Protein-based Inhibition of Mitotic Kinesins (March 11, 2022 2:00pm) https://events.umich.edu/event/92880 92880-21697632@events.umich.edu Event Begins: Friday, March 11, 2022 2:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

We are pleased to announce that April Solon will present her Dissertation Defense on March 11, 2022, in person at Kahn Auditorium (BSRB) and via live stream on Friday, March 11th at 2:00 pm!

April will present: Movement on Demand: Pharmacological and Protein-based Inhibition of Mitotic Kinesins

Livestream: https://umich.zoom.us/j/98859460380 Passcode: April

Hosted By the Dissertation Committee:
Professor: Nouri Neamati, Chair
Associate: Professor Puck Ohi, Mentor
Professor: Kristen Verhey
Professor: Howard Crawford

]]>
Lecture / Discussion Wed, 02 Mar 2022 12:20:16 -0500 2022-03-11T14:00:00-05:00 2022-03-11T15:00:00-05:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion Movement on Demand: Pharmacological and Protein-based Inhibition of Mitotic Kinesins
BioArtography - Call for Images (March 12, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701903@events.umich.edu Event Begins: Saturday, March 12, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-12T00:00:00-05:00 2022-03-12T23:59:00-05:00 BioArtography Other U-M BioArtography
BioArtography - Call for Images (March 13, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701904@events.umich.edu Event Begins: Sunday, March 13, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-13T00:00:00-05:00 2022-03-13T23:59:00-04:00 BioArtography Other U-M BioArtography
BioArtography - Call for Images (March 14, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701905@events.umich.edu Event Begins: Monday, March 14, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-14T00:00:00-04:00 2022-03-14T23:59:00-04:00 BioArtography Other U-M BioArtography
BIBC Neurosurgery Faculty Candidate (March 14, 2022 11:00am) https://events.umich.edu/event/92827 92827-21697073@events.umich.edu Event Begins: Monday, March 14, 2022 11:00am
Location: Medical Science Unit II
Organized By: BioInnovations in Brain Cancer

This Research Seminar is for the BioInnovations in Brain Cancer Tenure Track Faculty Search.

]]>
Conference / Symposium Mon, 28 Feb 2022 11:09:22 -0500 2022-03-14T11:00:00-04:00 2022-03-14T12:00:00-04:00 Medical Science Unit II BioInnovations in Brain Cancer Conference / Symposium Dr. Christof Fellmann - Research Seminar Flyer
MCDB Connell Lecture > Thomas C. Südhof, M.D. (March 14, 2022 3:00pm) https://events.umich.edu/event/90404 90404-21670709@events.umich.edu Event Begins: Monday, March 14, 2022 3:00pm
Location: Rackham Graduate School (Horace H.)
Organized By: Department of Molecular, Cellular, and Developmental Biology

Thomas C. Südhof is a Nobel-prize winning biochemist at Stanford University.

The Südhof laboratory studies how synapses form in the brain and how their properties are specified, which together organize neural circuits. Moreover, the Südhof laboratory examines how synapses become dysfunctional in neurodegenerative and neuropsychiatric disorders to pave the way for better therapies.

Dr. Südhof has had a remarkably productive career studying the molecular mechanisms controlling synaptic transmission and synaptogenesis. He is perhaps best known for his work identifying the core molecular machinery controlling the fusion of synaptic vesicles with the plasma membrane, including the calcium sensor synaptotagmin. His group also discovered neurexins and neuroligins, which are important cell-surface proteins controlling the specificity synapse formation.

In recent years, his group and collaborators have explored the molecular basis of several human diseases, including Alzheimer’s disease, schizophrenia and autism.

Dr. Südhof has been an HHMI Investigator since 1986 and is the recipient of many awards recognizing his fundamental contributions to neuroscience and cell/molecular biology--among them, induction into the National Academy of Sciences (2002), the Kavli Prize (2010), the Albert Lasker Award (2013) as well as the 2013 Nobel Prize in Physiology.

After Dr. Südhof’s seminar there will be a reception in the West Atrium of the Biological Sciences Building under the life-size model of a pterosaur (Quetzalcoatlus northropi, the largest known flying animal to ever live on earth).

Please join us on March 14 for what will no doubt be a fascinating talk and an opportunity to meet with Dr. Südhof and members of the U-M science community.


Connell Lecture
This special event is possible through an endowment from Priscilla Connell's family as a memorial to her career as a nature photographer.

]]>
Lecture / Discussion Mon, 28 Feb 2022 15:12:33 -0500 2022-03-14T15:00:00-04:00 2022-03-14T16:30:00-04:00 Rackham Graduate School (Horace H.) Department of Molecular, Cellular, and Developmental Biology Lecture / Discussion Portrait of Thomas Südhof
BioArtography - Call for Images (March 15, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701906@events.umich.edu Event Begins: Tuesday, March 15, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-15T00:00:00-04:00 2022-03-15T23:59:00-04:00 BioArtography Other U-M BioArtography
Integrating intersectionality into Environmental Health Sciences (March 15, 2022 12:00pm) https://events.umich.edu/event/92997 92997-21698985@events.umich.edu Event Begins: Tuesday, March 15, 2022 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

*Registered required.

Ami Zota, ScD, MS, is an Associate Professor in the Department of Environmental & Occupational Health at George Washington University's Milken School of Public Health. Dr. Zota’s work seeks to secure environmental justice and improve health equity through advancements in science, policy, and clinical practice. Her research identifies novel pathways linking social disparities, environmental exposures, and reproductive and children’s health.

The environmental research seminar series is organized by the Integrated Health Sciences Core of the Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD). More information about M-LEEaD and upcoming events can be found here: http://mleead.umich.edu/index.php

]]>
Lecture / Discussion Fri, 04 Mar 2022 09:34:10 -0500 2022-03-15T12:00:00-04:00 2022-03-15T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Integrating intersectionality into Environmental Health Sciences
“Mechanobiology of vertebrate gut morphogenesis" (March 15, 2022 4:00pm) https://events.umich.edu/event/92788 92788-21695466@events.umich.edu Event Begins: Tuesday, March 15, 2022 4:00pm
Location: Off Campus Location
Organized By: Center for Cell Plasticity and Organ Design

The Center for Cell Plasticity and Organ Design is proud to present the following seminar with guest speaker Nandan L. Nerurkar, PhD, Assistant Professor of Biomedical Engineering at Columbia University.

The talk is entitled, "Mechanobiology of vertebrate gut morphogenesis."

Faculty Host: Brendon Baker, PhD, Biomedical Engineering

For more information, please email Organogenesis@umich.edu

]]>
Lecture / Discussion Thu, 24 Feb 2022 21:22:04 -0500 2022-03-15T16:00:00-04:00 2022-03-15T17:00:00-04:00 Off Campus Location Center for Cell Plasticity and Organ Design Lecture / Discussion Nerurkar Flyer
Establishing Compositional Control in 2D and 3D Metal Sulfide Electrocatalysts to Drive CO2 and CO Conversion to Alcohols (March 15, 2022 4:00pm) https://events.umich.edu/event/84371 84371-21623617@events.umich.edu Event Begins: Tuesday, March 15, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Development of materials that address the growing dichotomy of simultaneously increasing energy demands and carbon emissions is an imperative that has progressively affected energy-related research efforts. An emerging technical avenue in this area is the conversion of vastly abundant renewable energy sources that can be harnessed and directed towards synthesis of traditionally fossil fuel-based products from atmospheric feedstocks like CO2. To this end, our work establishes structure—function relationships for materials within the versatile classes of MX2 (M = Mo, W; X = S, Se) and Chevrel-Phase (CP) MyMo6X8 (M = alkali, alkaline, transition or post-transition metal; y = 0-4; X = S, Se, Te) chalcogenides. The molybdenum sulfide structures from both families exhibit exceptional promise as CO2R catalysts. Furthermore, we have identified the CP catalyst framework as being selective towards the electrochemical reduction of CO2 and CO to methanol (only major liquid-phase product) under applied potentials as mild as -0.4 V vs RHE. Reactivity toward electrochemical reduction of CO2 and CO to methanol is correlated with increased population of chalcogen states, as confirmed via X-Ray Absorption Spectroscopy. Overall, this work seeks to unravel optimally reactive novel small-molecule reduction catalyst compositions.
Jesus Velazquez (University of California, Davis)

]]>
Other Tue, 15 Mar 2022 18:15:27 -0400 2022-03-15T16:00:00-04:00 2022-03-15T17:15:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Functional MRI 2021-22 Speaker Series with Kawin Setsompop, Ph.D. (March 15, 2022 4:00pm) https://events.umich.edu/event/92833 92833-21697181@events.umich.edu Event Begins: Tuesday, March 15, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Functional MRI Lab

Abstract:

Advances in MRI’s instrumentation, data acquisition, and reconstruction algorithms have opened up exciting opportunities for dramatic gains in MR image encoding efficiency, particularly through the use of continuous volumetric data acquisition strategies. In this talk, I will provide an overview of the on-going research in my lab in developing technologies in this direction. The goal of our work has been in moving towards more precise MR imaging, or ‘precision MRI’, where the targets have been in achieving: i) rapid and comprehensive, high-resolution brain exam with a wealth of precise quantitative tissue parameters and multi-tissue compartment information, and ii) high-speed mesoscale structural and functional imaging of the brain, where the imaging can be done precisely, free of the typical distortion and blurring artifacts that have plagued standard EPI and spiral acquisitions.

You can attend in person: 4 p.m. Chemistry & Dow Willard H Laboratory (Central Campus), Room 1300.

You can attend via Zoom: https://umich.zoom.us/j/96633733558, passcode: 721418

]]>
Lecture / Discussion Mon, 28 Feb 2022 13:18:26 -0500 2022-03-15T16:00:00-04:00 2022-03-15T17:30:00-04:00 Chemistry Dow Lab Functional MRI Lab Lecture / Discussion Kawin Setsompop, Ph.D.
BioArtography - Call for Images (March 16, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701907@events.umich.edu Event Begins: Wednesday, March 16, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-16T00:00:00-04:00 2022-03-16T23:59:00-04:00 BioArtography Other U-M BioArtography
MCDB Defense> Mechanisms of Lysosome Biogenesis and Regulation (March 16, 2022 1:30pm) https://events.umich.edu/event/93110 93110-21700730@events.umich.edu Event Begins: Wednesday, March 16, 2022 1:30pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Mentor: Ming Li

Hybrid event

Link and Passcode in the Weekly Update or
email: mcdb.seminar.info@umich.edu

]]>
Workshop / Seminar Tue, 08 Mar 2022 10:30:40 -0500 2022-03-16T13:30:00-04:00 2022-03-16T14:30:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow initials MCDB and cartoon of a microscope on a blue background
BioArtography - Call for Images (March 17, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701908@events.umich.edu Event Begins: Thursday, March 17, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-17T00:00:00-04:00 2022-03-17T23:59:00-04:00 BioArtography Other U-M BioArtography
“The Salivary Glands: Robust Sites for Infection and Transmission of SARS-CoV-2” (March 17, 2022 12:00pm) https://events.umich.edu/event/92751 92751-21695193@events.umich.edu Event Begins: Thursday, March 17, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

BIOGRAPHY
Born: August 3rd, 1981, Defiance, Ohio, United States of America

LICENSES & CERTIFICATIONS
Diplomate, Oral and Maxillofacial Pathology – American Board of Oral and Maxillofacial Pathology
Dental License(s) – Unrestricted Dental License, Commonwealth of Pennsylvania, DS039850
DEA Registration – US Department of Justice
CPR Certification – American Red Cross

HONORS, AWARDS, & NOTEWORTHY INVITED TALKS.
2021 American College of Rheumatology Convergence, Invited Speaker, “Epigenetics of Sjogren’s Syndrome.” November 2021. >600 Attendees/Views.

]]>
Lecture / Discussion Tue, 01 Mar 2022 11:08:51 -0500 2022-03-17T12:00:00-04:00 2022-03-17T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Lecture / Discussion Blake Warner, DDS, PhD, MPH Assistant Clinical Investigator Chief of the Salivary Disorders Unit and the Sjogren’s Syndrome Clinic NIH National Institute of Dental and Craniofacial Research
DCM&B Tools and Technology Seminar (March 17, 2022 12:00pm) https://events.umich.edu/event/89810 89810-21665888@events.umich.edu Event Begins: Thursday, March 17, 2022 12:00pm
Location: Off Campus Location
Organized By: DCMB Tools and Technology Seminar

This presentation will be remote only via Zoom

]]>
Presentation Mon, 07 Mar 2022 13:13:54 -0500 2022-03-17T12:00:00-04:00 2022-03-17T13:00:00-04:00 Off Campus Location DCMB Tools and Technology Seminar Presentation
LSI Seminar Series: William C. Mobley, M.D., Ph.D., University of California, San Diego (March 17, 2022 12:00pm) https://events.umich.edu/event/92761 92761-21695328@events.umich.edu Event Begins: Thursday, March 17, 2022 12:00pm
Location: Palmer Commons
Organized By: Life Sciences Institute (LSI)

Synapse dysfunction and loss are hallmarks of Alzheimer’s disease (AD), responsible for its clinical manifestations. Defining the molecular basis for deficits in synapse structure and function are essential for elucidating AD pathogenesis and promise to enhance discovery of effective treatments. Elderly adults with Down syndrome (DS) demonstrate many of the clinical and pathological manifestations of AD; the condition is referred to as AD-DS. While age is an important risk factor for both AD and AD-DS, how age intersects with underlying changes in brain function are unclear. Studies in DS provide an opportunity to decipher the biology that underlies the impact of age on the genetic factor known to be necessary for AD-DS, an increase in APP copy number. Studies of synapse dysfunction and loss are not well investigated in those with AD-DS. We will explore the age by gene interaction through cell biological and in vivo studies in a mouse model and in the AD-DS brain.


**About the Speaker**
William Mobley is a Distinguished Professor of Neurosciences and Associate Dean for Neurosciences Initiatives at the University of California, San Diego. He came to UCSD in June of 2009 from Stanford University, where he served as the John E. Cahill Family Professor in the Department of Neurology and Neurological Sciences and was the founding director of the Neuroscience Institute. He earned his Ph.D. in neuro- & behavioral science from Stanford University in Palo Alto, California in 1974 and an M.D. from the same institution in 1976. Dr. Mobley completed an internship in pathology in 1977 and a pediatric residency in 1979, both at Stanford University, followed by a residency and fellowship in Neurology and Pediatric Neurology at The Johns Hopkins University. While there, he was selected to serve as chief resident in pediatric neurology from 1981 to 1982. He is certified by both the American Board of Pediatrics and the American Board of Psychiatry and Neurology with Special Competence in Child Neurology. He is a past president of the Association of University Professors of Neurology, the Professors of Child Neurology, and the International Society for Developmental Neuroscience. He is also a Fellow of the Royal College of Physicians an elected member of the National Academy of Medicine. In 2006, Dr. Mobley was named a Fellow of the American Association for the Advancement of Science, in 2011 received the International Sisley-Jérôme Lejeune Prize for research in Down Syndrome, and in 2014 was named to the Johns Hopkins Society of Scholars. Dr. Mobley currently serves as president of the T21 Research Society. In 2019 he was appointed interim Director of the Sanford Institute for Empathy and Compassion. His research focuses on the biology of Alzheimer's disease, especially as manifest in those with Down syndrome. It encompasses studies that extend from basic cellular mechanisms to the discovery of treatments and to the compassionate care of these individuals.

]]>
Lecture / Discussion Thu, 24 Feb 2022 15:46:30 -0500 2022-03-17T12:00:00-04:00 2022-03-17T13:00:00-04:00 Palmer Commons Life Sciences Institute (LSI) Lecture / Discussion Life Sciences Institute Seminar Series
EEB Thursday Seminar: Genetic causes and organismal consequences of metabolic enzyme evolution (March 17, 2022 4:00pm) https://events.umich.edu/event/86328 86328-21632729@events.umich.edu Event Begins: Thursday, March 17, 2022 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Our weekly seminar series featuring internal and external speakers in the field of ecology and evolutionary biology.

This seminar will be in person and livestreamed on Zoom (link this page)

Image: The crystal structure is freely available online through the protein database (https://www.rcsb.org/structure/4iq8). Its specific structural ID is 4iq8. Mo processed the raw structure using a protein visualization software (PyMol) to display its most likely structure as a ribbon dimer and highlighted some residues of interest.

]]>
Workshop / Seminar Tue, 15 Mar 2022 12:46:16 -0400 2022-03-17T16:00:00-04:00 2022-03-17T17:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Illustration of an enzyme
BioArtography - Call for Images (March 18, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701909@events.umich.edu Event Begins: Friday, March 18, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-18T00:00:00-04:00 2022-03-18T23:59:00-04:00 BioArtography Other U-M BioArtography
U-M Structure Seminar: "High throughput screening of small molecule binding partners for the FMN riboswitch by a multidisciplinary approach" (March 18, 2022 10:00am) https://events.umich.edu/event/85436 85436-21626423@events.umich.edu Event Begins: Friday, March 18, 2022 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

Elizabeth Tidwell
Graduate Student
University of Michigan, Koutmos Lab

Hybrid: LSI Library and Zoom - https://umich.zoom.us/j/97763780708 (Password: structure)

]]>
Workshop / Seminar Thu, 03 Mar 2022 11:40:42 -0500 2022-03-18T10:00:00-04:00 2022-03-18T11:00:00-04:00 Life Sciences Institute U-M Structural Biology Workshop / Seminar U-M Structure
MCDB Seminar> Chemical Biology and Proteomic Approaches to Rare Disease and Cancer (March 18, 2022 12:00pm) https://events.umich.edu/event/90411 90411-21670716@events.umich.edu Event Begins: Friday, March 18, 2022 12:00pm
Location: Off Campus Location
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Yanzhuang Wang

Virtual event: For Zoom link and passcode, see the Weekly Update or
email: mcdb.seminar.info@umich.edu

]]>
Workshop / Seminar Wed, 09 Mar 2022 14:14:00 -0500 2022-03-18T12:00:00-04:00 2022-03-18T13:00:00-04:00 Off Campus Location Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow MCDB initials and microscope cartoon on blue background
BioArtography - Call for Images (March 19, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701910@events.umich.edu Event Begins: Saturday, March 19, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-19T00:00:00-04:00 2022-03-19T23:59:00-04:00 BioArtography Other U-M BioArtography
2022 University of Michigan Brain Bee (March 19, 2022 12:00pm) https://events.umich.edu/event/92806 92806-21695825@events.umich.edu Event Begins: Saturday, March 19, 2022 12:00pm
Location: Michigan League
Organized By: Michigan Brain Bee

The university of Michigan Brain Bee is a neuroscience competition open to all Michigan students in grades 9-12! The winner of the Michigan Brain Bee will win 250$ and the right to represent Michigan in the National Brain Bee, held remotely on April 9th, 2022. To learn more information and to register please see the link below!
https://sites.google.com/umich.edu/brainbee

]]>
Fair / Festival Fri, 25 Feb 2022 14:39:38 -0500 2022-03-19T12:00:00-04:00 2022-03-19T17:00:00-04:00 Michigan League Michigan Brain Bee Fair / Festival Michigan Brain Bee Logo
17th Annual Early Career Scientists Symposium (March 19, 2022 2:00pm) https://events.umich.edu/event/89657 89657-21664739@events.umich.edu Event Begins: Saturday, March 19, 2022 2:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

The Department of Ecology and Evolutionary Biology (EEB) at the University of Michigan presents the 17th Annual Early Career Scientists Symposium: Racial Justice and Anti-Racist Research in EEB. We are delighted to announce that our featured speaker, Steward Pickett, distinguished urban ecologist from the Cary Institute and this year’s eminent ecologist of the Ecological Society of America, will open the symposium. A panel discussion led by Nicholas Reo, Associate Professor of Native American Studies at Dartmouth will bring the symposium to its conclusion.

Eight early career scholars who are transforming our discipline through anti-racist and justice-centered research that pushes our understanding of the links between EEB research and society, will present their perspectives in many areas of EEB, such as Global Environmental Change, Genomics and Population Genetics, Urban Ecology and Evolution, Environmental History, STEM Education, Marine Ecology, Water Security, Theoretical Ecology and Evolution, Global Food Systems, and Disease Ecology. The goal of this symposium is to provide a space for the EEB community to think imaginatively about the future of our discipline.

The symposium will begin on Saturday, March 19, 2022 (2 - 6 pm EDT) in-person and live-streamed, followed by three consecutive virtual Fridays from March 25– April 8, 2022 (noon - 2 pm EDT). Two to three participants will present each Friday, followed by a moderated discussion.

**ALL TIMES ARE EDT (Eastern Daylight Time)**

While the symposium presents the work of rising early career scientists, it is open to all (i.e., you don’t have to be in your early career to attend).

REGISTRATION is required for in person and Zoom entry. You will be provided with the link and passcode upon registration. https://myumi.ch/ECSSregister

You must complete the UM ResponsiBLUE short questionnaire before you come to campus https://responsiblue.umich.edu/home

Please contact the planning committee with questions: ecss-2022@umich.edu

SPECIAL THANKS TO COSPONSORS CEW+ (Center for the Education of Women+) Irma M. Wyman Grant Program Fund and the Rackham Faculty Allies Diversity Grant!

Art by John Megahan based on a photo by Nick Reo. About the photo: Kanaka Maoli and Anishinaabe land and language warriors visit and exchange knowledge at Hale O Kuhio, a structure erected in 2018 to assert the unfulfilled mandate of the Hawaiian Homes Commission Act of 1920.

]]>
Conference / Symposium Fri, 04 Mar 2022 15:27:44 -0500 2022-03-19T14:00:00-04:00 2022-03-19T18:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Conference / Symposium Art by John Megahan based on a photo by Nick Reo. Kanaka Maoli and Anishinaabe land and language warriors visit and exchange knowledge at Hale O Kuhio, a structure erected in 2018 to assert the unfulfilled mandate of the Hawaiian Homes Commission Act of 1920.
BioArtography - Call for Images (March 20, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701911@events.umich.edu Event Begins: Sunday, March 20, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-20T00:00:00-04:00 2022-03-20T23:59:00-04:00 BioArtography Other U-M BioArtography
3rd Year Graduate Student Seminars (March 21, 2022 12:00am) https://events.umich.edu/event/91691 91691-21681612@events.umich.edu Event Begins: Monday, March 21, 2022 12:00am
Location: Off Campus Location
Organized By: Department of Chemistry

Inorganic
tba

]]>
Other Mon, 21 Mar 2022 18:15:28 -0400 2022-03-21T00:00:00-04:00 2022-03-21T00:00:00-04:00 Off Campus Location Department of Chemistry Other
BioArtography - Call for Images (March 21, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701912@events.umich.edu Event Begins: Monday, March 21, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-21T00:00:00-04:00 2022-03-21T23:59:00-04:00 BioArtography Other U-M BioArtography
Sea Changes: Experimental Collaborations across the Indian Ocean (March 21, 2022 12:00pm) https://events.umich.edu/event/89835 89835-21665913@events.umich.edu Event Begins: Monday, March 21, 2022 12:00pm
Location: Off Campus Location
Organized By: Institute for Social Research

Sea Changes: Experimental Collaborations across the Indian Ocean
Vivian Choi, St. Olaf College

Monday, Mar. 21, Open Talks will be held noon to 1pm, and the Grad Workshops will be held 1 to 3pm.
In-person in ISR-Thompson 6050
Presentations will also be available online via Zoom

Abstract:
Inspired by ethnographic accounts recounting the colors of the Indian Ocean in Eastern Sri Lanka, this talk explores the colors of the Indian Ocean, as social, political, and material reflections of life and death. While oceans are almost always described and associated with the color blue, these descriptions of past disasters — the black sludgy waters of the 2004 Indian Ocean tsunami and the red, blood-tinged sea from civil war violence — harken to the Indian Ocean’s significance as a reminder and a harbinger of danger. Scaling up, I then turn to ocean color science, which charts and models the presence or absence of phytoplankton as an indicator of the rapidly warming Indian Ocean basin, changing its hues to a deeper green and signaling broader concerns for and relations with biological life, weather, atmosphere and land. What might a broader spectrum of hues offer in contrast to dominant economic and security narratives of bluing? What might attention to Indian Ocean colors offer to examine the social and ecological impacts of planetary risk and danger?

This is a part of the Research Center for Group Dynamics (RCGD) Winter 2022 Series - "Water Ways: New Social Science, Science Studies, and Environmental Approaches to Water"

This is also a part of the class Anthrcul 558 section 002

]]>
Presentation Mon, 21 Mar 2022 12:33:43 -0400 2022-03-21T12:00:00-04:00 2022-03-21T15:00:00-04:00 Off Campus Location Institute for Social Research Presentation event flyer
Inaugural RNA Therapeutics Seminar (March 21, 2022 3:00pm) https://events.umich.edu/event/93388 93388-21704102@events.umich.edu Event Begins: Monday, March 21, 2022 3:00pm
Location: Palmer Commons
Organized By: Center for RNA Biomedicine

Michelle Hastings, Ph.D.
Professor, Cell Biology and Anatomy
Director, Center for Genetic Diseases
Rosalind Franklin University of Medicine and Science

This is an internal U-M event

Hybrid event:
In-person: Palmer Commons, Forum Hall
Zoom: https://myumi.ch/DJ6ky

]]>
Lecture / Discussion Mon, 21 Mar 2022 07:09:36 -0400 2022-03-21T15:00:00-04:00 2022-03-21T16:00:00-04:00 Palmer Commons Center for RNA Biomedicine Lecture / Discussion Michelle Hastings, Rosalind Franklin University
BioArtography - Call for Images (March 22, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701913@events.umich.edu Event Begins: Tuesday, March 22, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-22T00:00:00-04:00 2022-03-22T23:59:00-04:00 BioArtography Other U-M BioArtography
CSCS Hybrid Seminar: The role of non-conservative interactions in non-equilibrium stochastic systems (March 22, 2022 11:30am) https://events.umich.edu/event/93138 93138-21700936@events.umich.edu Event Begins: Tuesday, March 22, 2022 11:30am
Location: Weiser Hall
Organized By: The Center for the Study of Complex Systems

HYBRID SEMINAR
https://umich.zoom.us/j/96616169868 | Weiser Hall Room 747
Password: CSCS (all caps)

Abstract: The complex world surrounding us, including all living matter and various artificial complex systems, mostly operates far from thermal equilibrium. A major goal of modern statistical physics and thermodynamics is to unravel the fundamental principles that govern the individual dynamics and collective behavior of such nonequilibrium systems, like the swarming of fish or flocking of birds. A novel key concept to describe and classify nonequilibrium systems is the stochastic entropy production, which explicitly quantifies the breaking of time-reversal symmetry. However, so far, little attention has been paid to the implications of non-conservative interactions, such as time-delayed (i.e., retarded) or non-reciprocal interactions, which cannot be represented by Hamiltonians contrasting all interactions traditionally considered in statistical physics. Non-conservative interactions indeed emerge commonly in biological, chemical and feedback systems, and are widespread in engineering and machine learning. In this talk, I will use simple time- and space-continuous models to discuss technical challenges and unexpected physical phenomena induced by non-reciprocity [1,2] and time delay [3,4].

[1] Loos and Klapp, NJP 22, 123051 (2020)
[2] Loos, Hermann, and Klapp, Entropy 23, 696 (2021)
[3] Loos and Klapp, Sci. Rep. 9, 2491 (2019)
[4] Holubec, Geiss, Loos, Kroy, and Cichos, PRL 127, 258001 (2021)

]]>
Workshop / Seminar Tue, 08 Mar 2022 15:15:04 -0500 2022-03-22T11:30:00-04:00 2022-03-22T13:00:00-04:00 Weiser Hall The Center for the Study of Complex Systems Workshop / Seminar Sarah Loos
How A Ubiquitin-like Protein Brings Ubiquitin Ligases to Life- Department of Biological Chemistry Annual Greenberg Lecture (March 22, 2022 12:00pm) https://events.umich.edu/event/92442 92442-21691556@events.umich.edu Event Begins: Tuesday, March 22, 2022 12:00pm
Location: Off Campus Location
Organized By: Biological Chemistry

Dr. Brenda Schulman will present the annual Robert Greenberg Lectureship on Tuesday March 22 at 12:00noon via zoom

]]>
Workshop / Seminar Wed, 16 Feb 2022 12:39:14 -0500 2022-03-22T12:00:00-04:00 2022-03-22T13:00:00-04:00 Off Campus Location Biological Chemistry Workshop / Seminar Schulman
LHS Collaboratory (March 22, 2022 12:00pm) https://events.umich.edu/event/90095 90095-21667763@events.umich.edu Event Begins: Tuesday, March 22, 2022 12:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Presentation 1: PCORNet and the PaTH subnetwork

Kathleen McTigue, MD, MPH, MS

In this talk, Kathleen McTigue describes the vision of PCORNet, its organization, and its value to the field of clinical research. PCORNet is divided into regional subnetworks one of which is PaTH. The organization of PaTH along with its priories will be discussed.

Presentation 2: UM’s site within PCORNet/PaTH

David Williams, PhD

The University of Michigan is an institutional member of PaTH/PCORNet.
In this talk, David Williams describes the organization and processes of the UM site within PCORNet/PaTH, studies in which UM participates, and resources for UM investigators interested in participating in PCORNet studies.

]]>
Lecture / Discussion Wed, 15 Dec 2021 22:38:45 -0500 2022-03-22T12:00:00-04:00 2022-03-22T13:30:00-04:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion Collaboratory logo
MCDB Defense> Characterization of unstudied genes important for survival to DNA damage in damage-independent replication fork arrest (March 22, 2022 12:00pm) https://events.umich.edu/event/93111 93111-21700731@events.umich.edu Event Begins: Tuesday, March 22, 2022 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Mentor: Lyle Simmons

Hybrid event:
link and passcode in Weekly Update or
email: mcdb.seminar.info@umich.edu

]]>
Workshop / Seminar Tue, 08 Mar 2022 10:35:53 -0500 2022-03-22T12:00:00-04:00 2022-03-22T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow initials MCDB and cartoon of a microscope on a blue background
Operationalizing the exposome through chemical surveillance & bioeffect monitoring with high-resolution mass spectrometry (March 22, 2022 12:00pm) https://events.umich.edu/event/93450 93450-21704620@events.umich.edu Event Begins: Tuesday, March 22, 2022 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Registration required https://umich.zoom.us/webinar/register/WN_wum4p_pdRMKIixVZJAlicg

Douglas Walker is assistant professor in the Dept of Environmental Medicine & Public Health, Icahn School of Medicine, Mount Sinai. Dr. Walker's research is focused on using untargeted metabolomics to measure environmental exposures, and how exposures lead to biological changes that cause diseases. During his postdoctoral fellowship at Emory University, he acted as Director of Exposome Research for the Clinical Biomarkers Laboratory and was a member of the HERCULES Exposome Research Center. Through application of high-resolution mass spectrometry platforms, Dr. Walker has shown it is possible to provide measures of 10,000-100,000 chemical signals in a cost-effective manner using a single human blood sample, providing a key advance for nutritional assessment, precision medicine and exposome research. At Mount Sinai, his research will be focus on continued development and application of advanced analytical strategies for measuring the occurrence, distribution and magnitude of previously unidentified environmental exposures and assist in delineating the mechanisms underlying environment-related diseases in humans.

]]>
Lecture / Discussion Tue, 15 Mar 2022 13:21:33 -0400 2022-03-22T12:00:00-04:00 2022-03-22T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Dr. Douglas Walker (Mt. Sinai) presents the M-LEEaD Environmental Research Seminar
BioArtography - Call for Images (March 23, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701914@events.umich.edu Event Begins: Wednesday, March 23, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-23T00:00:00-04:00 2022-03-23T23:59:00-04:00 BioArtography Other U-M BioArtography
BioArtography - Call for Images (March 24, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701915@events.umich.edu Event Begins: Thursday, March 24, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-24T00:00:00-04:00 2022-03-24T23:59:00-04:00 BioArtography Other U-M BioArtography
DCM&B Tools and Technology Seminar (March 24, 2022 12:00pm) https://events.umich.edu/event/89811 89811-21665889@events.umich.edu Event Begins: Thursday, March 24, 2022 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

]]>
Presentation Tue, 07 Dec 2021 09:06:13 -0500 2022-03-24T12:00:00-04:00 2022-03-24T13:00:00-04:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
EEB Thursday Seminar: Assembling communities in a changing world: how changing climates and invading species are reshaping our ecosystems (March 24, 2022 4:00pm) https://events.umich.edu/event/85737 85737-21628576@events.umich.edu Event Begins: Thursday, March 24, 2022 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Our weekly seminar series featuring internal and external speakers in the field of ecology and evolutionary biology.

This seminar will be in person and livestreamed on Zoom (link this page).

Image: Megan Ryan

]]>
Workshop / Seminar Mon, 14 Mar 2022 12:23:54 -0400 2022-03-24T16:00:00-04:00 2022-03-24T17:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Two people walking on a trail away from the camera through the woods
BioArtography - Call for Images (March 25, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701916@events.umich.edu Event Begins: Friday, March 25, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-25T00:00:00-04:00 2022-03-25T23:59:00-04:00 BioArtography Other U-M BioArtography
6th Annual RNA Symposium (March 25, 2022 8:00am) https://events.umich.edu/event/93125 93125-21700908@events.umich.edu Event Begins: Friday, March 25, 2022 8:00am
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Symposium Agenda

8:30 / Morning Welcome: President Mary Sue Coleman
8:40 / Jack Szostak "The emergence of RNA from heterogeneous prebiotic chemistry"
9:35 / Gigi Storz "RNA-mediated regulation within protein-coding sequences"
10:30 / coffee break
10:55 / Chris Burge "Impact of RNA-Binding Proteins on Human Genomic Variation"
12:00 / Lunch - please register for free box lunch
1:00 / Afternoon Welcome: Rebecca Cunningham, Vice President for Research
1:10 / Wendy Gilbert “Decoding the untranslated”
2:05 / Michelle Hastings "Splice-Modulating Antisense Oligonucleotides for the Treatment of Disease"
2:55 / Panel discussion with keynote speakers
Topic: Future of RNA Therapeutics, moderated by John Androsavich, Pfizer Global Lead, RNA Medicine

]]>
Lecture / Discussion Wed, 16 Mar 2022 15:43:32 -0400 2022-03-25T08:00:00-04:00 2022-03-25T16:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion 6th Annual RNA Symposium
Beneficial virus: evolutionary, modeling & clinical perspectives on phage (March 25, 2022 9:00am) https://events.umich.edu/event/88027 88027-21648632@events.umich.edu Event Begins: Friday, March 25, 2022 9:00am
Location: Rackham Graduate School (Horace H.)
Organized By: MAC-EPID

SPEAKERS INCLUDE:

Stephanie Strathdee, PhD (Associate Dean of Global Health Sciences; Harold Simon Professor, UCSD Department of Medicine; Co-Director, Center for Innovative Phage Applications and Therapeutics; Author of The Perfect Predator)

Vivek Mutalik, PhD (Staff Scientist, Environmental Genomics and Systems Biology: Comparative and Functional Genomics; Biological Systems and Engineering: Organismal Systems & Bioresilience, Biodesign at Lawrence Berkeley National Laboratory)

Samuel Brown, PhD (Professor, Georgia Tech Biological Sciences)

Gina Suh, M.D. (Senior Associate Consultant, Division of Infectious Diseases, Department of Internal Medicine. Assistant Professor of Medicine, Mayo Clinic)

* * * * *
Coffee hour directly following talks.
Please register for this free symposium since lunch will be provided. Thank you!

For more information and registration for this FREE event:
www.MAC-EPID.org
Anna Cronenwett, weaverd@umich.edu

]]>
Conference / Symposium Thu, 07 Oct 2021 13:05:57 -0400 2022-03-25T09:00:00-04:00 2022-03-25T16:00:00-04:00 Rackham Graduate School (Horace H.) MAC-EPID Conference / Symposium Event Flyer
17th Annual Early Career Scientists Symposium (March 25, 2022 12:00pm) https://events.umich.edu/event/89659 89659-21664740@events.umich.edu Event Begins: Friday, March 25, 2022 12:00pm
Location: Off Campus Location
Organized By: Ecology and Evolutionary Biology

The Department of Ecology and Evolutionary Biology (EEB) at the University of Michigan presents the 17th Annual Early Career Scientists Symposium: Racial Justice and Anti-Racist Research in EEB. We are delighted to announce that our featured speaker, Steward Pickett, distinguished urban ecologist from the Cary Institute and this year’s eminent ecologist of the Ecological Society of America, will open the symposium. A panel discussion led by Nicholas Reo, Associate Professor of Native American Studies at Dartmouth will bring the symposium to its conclusion.

Eight early career scholars who are transforming our discipline through anti-racist and justice-centered research that pushes our understanding of the links between EEB research and society, will present their perspectives in many areas of EEB, such as Global Environmental Change, Genomics and Population Genetics, Urban Ecology and Evolution, Environmental History, STEM Education, Marine Ecology, Water Security, Theoretical Ecology and Evolution, Global Food Systems, and Disease Ecology. The goal of this symposium is to provide a space for the EEB community to think imaginatively about the future of our discipline.

The symposium will begin on Saturday, March 19, 2022 (2 - 6 pm EDT) in-person and live-streamed, followed by three consecutive virtual Fridays (noon - 2 pm EDT) from March 25– April 8, 2022. Two to three participants will present each Friday, followed by a moderated discussion. For the symposium, we consider early career scientists as senior graduate students (who stand to receive their Ph.D. within two years), postdoctoral researchers, faculty or staff scientists within their first or second year, and researchers at equivalent career stages who are not affiliated with an academic institution.

While the symposium presents the work of rising early career scientists, it is open to all (i.e., you don’t have to be in your early career to attend).

Please contact the planning committee with questions: ecss-2022@umich.edu.

REGISTRATION is required for Zoom entry. You will be provided with the link and passcode upon registration. https://myumi.ch/ECSSregister

SPECIAL THANKS TO COSPONSORS CEW+ (Center for the Education of Women+) Irma M. Wyman Grant Program Fund and the Rackham Faculty Allies Diversity Grant!

Art by John Megahan based on a photo by Nick Reo. Kanaka Maoli and Anishinaabe land and language warriors visit and exchange knowledge at Hale O Kuhio, a structure erected in 2018 to assert the unfulfilled mandate of the Hawaiian Homes Commission Act of 1920.

]]>
Livestream / Virtual Fri, 04 Mar 2022 15:29:01 -0500 2022-03-25T12:00:00-04:00 2022-03-25T14:00:00-04:00 Off Campus Location Ecology and Evolutionary Biology Livestream / Virtual Art by John Megahan based on a photo by Nick Reo. Kanaka Maoli and Anishinaabe land and language warriors visit and exchange knowledge at Hale O Kuhio, a structure erected in 2018 to assert the unfulfilled mandate of the Hawaiian Homes Commission Act of 1920.
MCDB Seminar> Leaving a mark: Formation of distinct plasma membrane domains on the pollen surface (March 25, 2022 12:00pm) https://events.umich.edu/event/90413 90413-21670788@events.umich.edu Event Begins: Friday, March 25, 2022 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Cora MacAlister

]]>
Workshop / Seminar Fri, 04 Mar 2022 11:57:01 -0500 2022-03-25T12:00:00-04:00 2022-03-25T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar images of pollen in yin yang pattern on black background
UM Structure Seminar: "Structures in situ: Discovering a new lattice inside alpha-carboxysomes" (March 25, 2022 12:00pm) https://events.umich.edu/event/89500 89500-21663332@events.umich.edu Event Begins: Friday, March 25, 2022 12:00pm
Location: Life Sciences Institute
Organized By: U-M Structural Biology

Lauren Ann Metskas, Ph.D.
Assistant Professor
Purdue University

]]>
Lecture / Discussion Mon, 28 Feb 2022 08:56:39 -0500 2022-03-25T12:00:00-04:00 2022-03-25T13:00:00-04:00 Life Sciences Institute U-M Structural Biology Lecture / Discussion U-M Structure
BioArtography - Call for Images (March 26, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701917@events.umich.edu Event Begins: Saturday, March 26, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-26T00:00:00-04:00 2022-03-26T23:59:00-04:00 BioArtography Other U-M BioArtography
BioArtography - Call for Images (March 27, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701918@events.umich.edu Event Begins: Sunday, March 27, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-27T00:00:00-04:00 2022-03-27T23:59:00-04:00 BioArtography Other U-M BioArtography
3rd year Graduate Student Seminars (March 28, 2022 12:00am) https://events.umich.edu/event/91692 91692-21681613@events.umich.edu Event Begins: Monday, March 28, 2022 12:00am
Location: Off Campus Location
Organized By: Department of Chemistry

Inorganic
tba

]]>
Other Mon, 28 Mar 2022 18:15:25 -0400 2022-03-28T00:00:00-04:00 2022-03-28T00:00:00-04:00 Off Campus Location Department of Chemistry Other
BioArtography - Call for Images (March 28, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701919@events.umich.edu Event Begins: Monday, March 28, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-28T00:00:00-04:00 2022-03-28T23:59:00-04:00 BioArtography Other U-M BioArtography
RNA Innovation Seminar: "Marvelous U: Canonical and non-canonical functions of uridine modifying enzymes in health and disease" (March 28, 2022 4:00pm) https://events.umich.edu/event/92831 92831-21697176@events.umich.edu Event Begins: Monday, March 28, 2022 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

In-person/Hybrid seminar

Talk title: “Marvelous U: Canonical and non-canonical functions of uridine modifying enzymes in health and disease"

Keywords: RNA modifications, RNA processing, RNA folding, pre-mRNA, tRNA, translation, cancer

Abstract: RNA modifications are essential for human health—too much or too little leads to serious illnesses ranging from neurodevelopmental disorders to cancer. We are working to uncover the RNA targets of RNA modifying enzymes that are dysregulated in disease and to understand their molecular and organismal roles. Recent advances in detecting the modified nucleosides pseudouridine and dihydrouridine reveal complex landscapes that include pre-messenger RNA and diverse classes of noncoding RNA in yeast and human cells. I will give an update on our progress towards answering three questions: How are specific RNA sites selected for modification and how is this process regulated? What are the molecular consequences of mRNA and non-coding RNA modifications? How do specific defects in RNA metabolism result in organismal phenotypes, including disease?

Brief Bio:
Wendy Gilbert is an Associate Professor of Molecular Biophysics and Biochemistry. Her work focuses on regulatory elements in messenger RNA that control the cellular expression of the information stored in the genetic code. She earned her PhD at UCSF with Christine Guthrie, studying mRNA export and being fascinated by the exquisite mechanisms that couple export-competence to completion of RNA processing. As a postdoc in Jennifer Doudna’s lab at UC Berkeley, she uncovered a non-canonical mechanism of translation initiation. She started her lab at MIT in 2008 and joined the faculty at Yale in 2017. Her lab’s current work ranges widely across RNA biology with the unifying theme of elucidating the molecular mechanisms of RNA regulatory elements controlling mRNA biogenesis, translation and decay. Most recently, this has been in the area of RNA base modification. She was recognized with the RNA Society’s Early Career Award in 2017 for her “paradigm-altering contributions to the field of post-transcriptional gene regulation.”

If you are having trouble registering, please contact Martina Jerant at mjerant@umich.edu

]]>
Lecture / Discussion Mon, 14 Mar 2022 15:29:11 -0400 2022-03-28T16:00:00-04:00 2022-03-28T17:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion Wendy Gilbert, Yale School of Medicine
BioArtography - Call for Images (March 29, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701920@events.umich.edu Event Begins: Tuesday, March 29, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-29T00:00:00-04:00 2022-03-29T23:59:00-04:00 BioArtography Other U-M BioArtography
Mechanisms of Organelle Trafficking, Inheritance, and Homeostasis in Bacteria- Department of Biological Chemistry Seminar (March 29, 2022 12:00pm) https://events.umich.edu/event/92443 92443-21691557@events.umich.edu Event Begins: Tuesday, March 29, 2022 12:00pm
Location: Medical Science Unit I
Organized By: Biological Chemistry

Dr. Vecchiarelli will present a seminar in person in room 5330 MS I at 12 noon

]]>
Workshop / Seminar Wed, 16 Feb 2022 12:43:04 -0500 2022-03-29T12:00:00-04:00 2022-03-29T13:00:00-04:00 Medical Science Unit I Biological Chemistry Workshop / Seminar Vecchiarelli
A New Way to Stop the Spread of Viral Respiratory Infections (March 29, 2022 4:00pm) https://events.umich.edu/event/93801 93801-21708246@events.umich.edu Event Begins: Tuesday, March 29, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

I want to speak about viral respiratory diseases, such as influenza and COVID-19. When COVID-19 first appeared, public health authorities worried about the new coronavirus being spread by contact with large fluid droplets or by residues upon droplet evaporation. The guidance for individual behavior that was given included washing hands, cleaning groceries, wearing face coverings, avoiding people who sneeze or cough, and keeping some social distance apart from other individuals. But a detailed understanding of flu transmission, which took decades to develop, led scientists to understand only relatively recently that SARS-CoV-2 follows the same path of airborne transmission. Researchers found that the virus is breathed out in small particles by infected individuals while talking, singing, sneezing, and coughing. And these viruses have been found in many indoor environments. Those infected can even spread the virus when showing no symptoms of being sick, which shows that transmission does not depend on coughing or sneezing. Large wet droplets are not required for transmission.

The transmission of many infectious diseases requires that pathogens can survive, that is, remain infectious, in the environment, outside the host. It has long been recognized that viral respiratory diseases show a seasonal variation in temperate parts of the world, such that they increase in the winter but decrease in the summer. This behavior is strongly correlated with outside temperature, but viruses are hardy and are not killed by temperature changes of the outdoors. Instead, evidence has accumulated that the correlation is strongest with relative humidity in which viruses show U-shaped viability, surviving best in high or low humidity but surviving much more poorly in the relative humidity range of 40 to 60 %.[1] People in temperate regions of the world spend about 90% of their time indoors, and the relative humidity of indoor air is typically much reduced in the wintertime caused by heating of the indoor air which is necessary to keep people warm.[2] Evidence will be presented that relative humidity affects the evaporation rate of aqueous microdroplets (aerosols) in the air, and that relative humidity values of 40-60% provide enough time to kill viruses in aqueous microdroplets.[3] This conclusion explains this seasonal variation, which has heretofore been quite puzzling and often ignored. We find that this killing is promoted by the presence of reactive oxygen species (ROS) in aqueous microdroplets in the size range of 1 to 20 microns in diameter. The possible mechanism for the formation of ROS will be discussed.

References:

1. Lin K, Marr LC. (2020) "Humidity-dependent decay of viruses, but not bacteria, in aerosols and droplets follows disinfection kinetics," Environmental Science & Technology 54, 1024-1032.
2. Bozic A, Kanduc M. (2021) "Relative humidity in droplet and airborne transmission of disease." Journal of Biological Physics 47,1-29.
3. Dulay MT, Huerta Aguila AC, Chamberlayne CF, Zare RN, Davidse A, Vukovic S. (2021), "Effect of Relative Humidity on Hydrogen Peroxide Production in Water Droplets," QRB Discovery 2, e8, 1-6.





Dick Zare (Stanford University)

]]>
Other Tue, 29 Mar 2022 18:15:35 -0400 2022-03-29T16:00:00-04:00 2022-03-29T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
BioArtography - Call for Images (March 30, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701921@events.umich.edu Event Begins: Wednesday, March 30, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-30T00:00:00-04:00 2022-03-30T23:59:00-04:00 BioArtography Other U-M BioArtography
The Role of Specialized Cell Cycles During Erythroid Lineage Development (March 30, 2022 9:30am) https://events.umich.edu/event/91810 91810-21683063@events.umich.edu Event Begins: Wednesday, March 30, 2022 9:30am
Location: Off Campus Location
Organized By: Cell & Developmental Biology

CDB 2022 Seminar Series (In person & Virtual):

We are pleased to welcome Merav Socolovsky, Ph.D., to present on Wednesday, March 30, 2022, from 9:30 – 10:30 am, (BSRB - Kahn Auditorium and virtual event). She will present “The Role of Specialized Cell Cycles During Erythroid Lineage Development.”

Zoom Meeting link:
https://umich.zoom.us/j/91043855664

Hosted by Doug Engel, Ph.D.

]]>
Lecture / Discussion Thu, 10 Mar 2022 10:30:38 -0500 2022-03-30T09:30:00-04:00 2022-03-30T10:30:00-04:00 Off Campus Location Cell & Developmental Biology Lecture / Discussion The Role of Specialized Cell Cycles During Erythroid Lineage Development
DCMB / CCMB Weekly Seminar presents Rehan Akbani, PhD (Associate Professor, University of Texas, MD Anderson Cancer Center) (March 30, 2022 4:00pm) https://events.umich.edu/event/93933 93933-21711327@events.umich.edu Event Begins: Wednesday, March 30, 2022 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

The TP53 tumor suppressor gene is frequently mutated in human cancers. We illustrate the “omics” landscape of the TP53 pathway across five data platforms in 10,225 patient samples from 33 cancers reported by The Cancer Genome Atlas (TCGA). More than 91% of TP53-mutant cancers exhibit second allele loss by mutation, chromosomal deletion, or copy-neutral loss of heterozygosity. TP53 mutations are associated with enhanced chromosomal instability, including increased amplification of oncogenes and deep deletion of tumor suppressor genes. Tumors with TP53 mutations differ from their non-mutated counterparts in RNA, miRNA, and protein expression patterns, with mutant TP53 tumors displaying enhanced expression of cell cycle progression genes and proteins. A mutant TP53 RNA expression signature shows significant correlation with reduced survival in 11 cancer types. Pathway activity scores were computed for all the samples using mRNA expression levels of ten TP53 pathway member genes. Gynecologic cancers show high activity of the pathway. The pathway is correlated with immune infiltration and EMT, and anti-correlated with RTK and RAS/MAPK pathways. In particular, a strong correlation with immune infiltration is observed in breast cancer. ATAC-seq data also show high chromatin accessibility of the pathway genes in breast cancer. Thus, the TP53 pathway has profound effects on tumor cell genomic structure, expression, and clinical outlook depending on tumor type.

Short Bio
Dr. Rehan Akbani is an Associate Professor at the University of Texas MD Anderson Cancer Center in Houston, Texas, in the Department of Bioinformatics and Computational Biology. He has worked at MD Anderson since 2009. He has played many leadership roles in major enterprises, including as PI on TCGA’s MD Anderson Genome Data Analysis Center (GDAC) grant. Within the TCGA consortium, he led four of TCGA’s analysis working groups and he’s been a co-author on each one of TCGA’s 33 marker papers and 27 pan-cancer papers since 2009. His primary contributions have been leading the analysis of proteomics data, and batch effects and quality control of omics data. He won the AACR “Team Science Award” in 2020 for his work in TCGA. He was conferred the “Highly Cited Researchers 2019” award by Web of Science for co-authoring the most highly cited papers in the past decade. He has over 87,700 citations and an h-index of 78 on Google Scholar. In 2014, he won the “Test of Time” award from the European Conference on Machine Learning (ECML) for publishing the most highly cited paper in ECML a decade ago. Currently, Dr. Akbani is the Co-Director of MD Anderson’s proteomics core and Co-Director of the metabolomics core, where he’s led the development of software pipelines for normalizing raw data and generating customer reports semi-automatically. He’s also contributed proteomics data analysis for projects including the Cancer Cell Line Encyclopedia (CCLE) and the MD Anderson Cell Line Project (MCLP).

Host: Veera Baladandayuthapani, Ph.D.
https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

]]>
Lecture / Discussion Thu, 24 Mar 2022 12:32:18 -0400 2022-03-30T16:00:00-04:00 2022-03-30T17:00:00-04:00 Off Campus Location DCMB Seminar Series Lecture / Discussion Rehan Akbani, PhD (Associate Professor, University of TX MD Anderson Cancer Center)
BioArtography - Call for Images (March 31, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701922@events.umich.edu Event Begins: Thursday, March 31, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-31T00:00:00-04:00 2022-03-31T23:59:00-04:00 BioArtography Other U-M BioArtography
“Bioengineered Synthetic Hydrogels for Regenerative Medicine" (March 31, 2022 12:00pm) https://events.umich.edu/event/92752 92752-21695194@events.umich.edu Event Begins: Thursday, March 31, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

Andrés J. García is the Executive Director of the Petit Institute for Bioengineering and Bioscience and Regents’ Professor at the Georgia Institute of Technology. Dr. García’s research program integrates innovative engineering, materials science, and cell biology concepts and technologies to create cell-instructive biomaterials for regenerative medicine and generate new knowledge in mechanobiology. This cross-disciplinary effort has resulted in new biomaterial platforms that elicit targeted cellular responses and tissue repair in various biomedical applications, innovative technologies to study and exploit cell adhesive interactions, and new mechanistic insights into the interplay of mechanics and cell biology.

In addition, his research has generated intellectual property and licensing agreements with start-up and multi-national companies. He is a co-founder of 3 start-up companies (CellectCell, CorAmi Therapeutics, iTolerance). He has received several distinctions, including the NSF CAREER Award, Young Investigator Award from the Society for Biomaterials, Georgia Tech’s Outstanding Interdisciplinary Activities Award, the Clemson Award for Basic Science from the Society for Biomaterials, the International Award from the European Society for Biomaterials, and Georgia Tech’s Class of 1934 Distinguished Professor Award.

He is an elected Fellow of Biomaterials Science and Engineering (by the International Union of Societies of Biomaterials Science and Engineering), Fellow of the American Association for the Advancement of Science, Fellow of the American Society of Mechanical Engineers, and Fellow of the American Institute for Medical and Biological Engineering. He served as President for the Society for Biomaterials in 2018-2019. He is an elected member of the National Academy of Engineering, the National Academy of Medicine, and the National Academy of Inventors.

]]>
Lecture / Discussion Fri, 18 Mar 2022 10:06:32 -0400 2022-03-31T12:00:00-04:00 2022-03-31T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Lecture / Discussion Andrés J. García, Ph.D.
DCM&B Tools and Technology Seminar (March 31, 2022 12:00pm) https://events.umich.edu/event/89812 89812-21665890@events.umich.edu Event Begins: Thursday, March 31, 2022 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

]]>
Presentation Thu, 27 Jan 2022 12:48:19 -0500 2022-03-31T12:00:00-04:00 2022-03-31T13:00:00-04:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
EEB Thursday Seminar: Intractable species boundaries and their implications for speciation and the assembly of continental faunas (March 31, 2022 4:00pm) https://events.umich.edu/event/86026 86026-21631132@events.umich.edu Event Begins: Thursday, March 31, 2022 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Our weekly seminar series featuring internal and external speakers in the field of ecology and evolutionary biology. This seminar will be in person and livestreamed on Zoom (link this page).

Image: Ivan Prates

]]>
Workshop / Seminar Thu, 24 Mar 2022 10:54:15 -0400 2022-03-31T16:00:00-04:00 2022-03-31T17:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Complex species boundaries impact inferences in macroecology and macroevolution. Top left, the relationship between geographic range size and climatic niche breadth across 900 species of Australian lizards and snakes. Top right, major biomes in the Australian continent. Center, illustration of molecular delimitation of operational candidate species in a subclade of lizards; genotypic clustering and phylogenetic patterns are shown. Bottom: Representative examples of variation in range size in Ctenotus lizards.
Physics-Inspired Machine Learning Methods: A Status Report on Predictive Chemistry (March 31, 2022 4:00pm) https://events.umich.edu/event/91346 91346-21678335@events.umich.edu Event Begins: Thursday, March 31, 2022 4:00pm
Location: Off Campus Location
Organized By: Department of Chemistry

Physical
Teresa Head-Gordon (University of California - Berkeley)

]]>
Other Thu, 31 Mar 2022 18:15:33 -0400 2022-03-31T16:00:00-04:00 2022-03-31T17:30:00-04:00 Off Campus Location Department of Chemistry Other
BioArtography - Call for Images (April 1, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701923@events.umich.edu Event Begins: Friday, April 1, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-01T00:00:00-04:00 2022-04-01T23:59:00-04:00 BioArtography Other U-M BioArtography
17th Annual Early Career Scientists Symposium (April 1, 2022 12:00pm) https://events.umich.edu/event/89659 89659-21664741@events.umich.edu Event Begins: Friday, April 1, 2022 12:00pm
Location: Off Campus Location
Organized By: Ecology and Evolutionary Biology

The Department of Ecology and Evolutionary Biology (EEB) at the University of Michigan presents the 17th Annual Early Career Scientists Symposium: Racial Justice and Anti-Racist Research in EEB. We are delighted to announce that our featured speaker, Steward Pickett, distinguished urban ecologist from the Cary Institute and this year’s eminent ecologist of the Ecological Society of America, will open the symposium. A panel discussion led by Nicholas Reo, Associate Professor of Native American Studies at Dartmouth will bring the symposium to its conclusion.

Eight early career scholars who are transforming our discipline through anti-racist and justice-centered research that pushes our understanding of the links between EEB research and society, will present their perspectives in many areas of EEB, such as Global Environmental Change, Genomics and Population Genetics, Urban Ecology and Evolution, Environmental History, STEM Education, Marine Ecology, Water Security, Theoretical Ecology and Evolution, Global Food Systems, and Disease Ecology. The goal of this symposium is to provide a space for the EEB community to think imaginatively about the future of our discipline.

The symposium will begin on Saturday, March 19, 2022 (2 - 6 pm EDT) in-person and live-streamed, followed by three consecutive virtual Fridays (noon - 2 pm EDT) from March 25– April 8, 2022. Two to three participants will present each Friday, followed by a moderated discussion. For the symposium, we consider early career scientists as senior graduate students (who stand to receive their Ph.D. within two years), postdoctoral researchers, faculty or staff scientists within their first or second year, and researchers at equivalent career stages who are not affiliated with an academic institution.

While the symposium presents the work of rising early career scientists, it is open to all (i.e., you don’t have to be in your early career to attend).

Please contact the planning committee with questions: ecss-2022@umich.edu.

REGISTRATION is required for Zoom entry. You will be provided with the link and passcode upon registration. https://myumi.ch/ECSSregister

SPECIAL THANKS TO COSPONSORS CEW+ (Center for the Education of Women+) Irma M. Wyman Grant Program Fund and the Rackham Faculty Allies Diversity Grant!

Art by John Megahan based on a photo by Nick Reo. Kanaka Maoli and Anishinaabe land and language warriors visit and exchange knowledge at Hale O Kuhio, a structure erected in 2018 to assert the unfulfilled mandate of the Hawaiian Homes Commission Act of 1920.

]]>
Livestream / Virtual Fri, 04 Mar 2022 15:29:01 -0500 2022-04-01T12:00:00-04:00 2022-04-01T14:00:00-04:00 Off Campus Location Ecology and Evolutionary Biology Livestream / Virtual Art by John Megahan based on a photo by Nick Reo. Kanaka Maoli and Anishinaabe land and language warriors visit and exchange knowledge at Hale O Kuhio, a structure erected in 2018 to assert the unfulfilled mandate of the Hawaiian Homes Commission Act of 1920.
MCDB Seminar > Transcriptional reprogramming of neural circuits with social experience (April 1, 2022 12:00pm) https://events.umich.edu/event/92830 92830-21697175@events.umich.edu Event Begins: Friday, April 1, 2022 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Josie Clowney

]]>
Workshop / Seminar Tue, 22 Mar 2022 22:17:26 -0400 2022-04-01T12:00:00-04:00 2022-04-01T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow MCDB initials and Microscope on blue
BioArtography - Call for Images (April 2, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742264@events.umich.edu Event Begins: Saturday, April 2, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-02T00:00:00-04:00 2022-04-02T23:59:00-04:00 BioArtography Other U-M BioArtography
BioArtography - Call for Images (April 3, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742265@events.umich.edu Event Begins: Sunday, April 3, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-03T00:00:00-04:00 2022-04-03T23:59:00-04:00 BioArtography Other U-M BioArtography
BioArtography - Call for Images (April 4, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742266@events.umich.edu Event Begins: Monday, April 4, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-04T00:00:00-04:00 2022-04-04T23:59:00-04:00 BioArtography Other U-M BioArtography
Proteostasis and Viral Evolution (April 4, 2022 4:00pm) https://events.umich.edu/event/85240 85240-21626064@events.umich.edu Event Begins: Monday, April 4, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Our group is broadly interested in understanding how cells fold complex proteins, as well as in the design and application of next-generation in vivo directed evolution platforms. In recent work, we used chemical genetic tools for controlling mammalian proteostasis networks to reveal that RNA viruses hijack host chaperones to facilitate their rapid evolution. This phenomenon has proven broadly significant for understanding viral adaptation and pathology. More recently, we discovered that host protein quality control mechanisms (as opposed to folding chaperones) can have the opposite effect on viral evolution -- effectively constraining viral mutational space. The connections drawn between host proteostasis and viral evolution have potentially significant implications for topics including viral host-switching, vaccine development, and the design of improved antiviral therapeutic strategies. Moreover, these principles may provide strategies to turbo-charge directed evolution campaigns aimed at the development of new biotechnologies.

Matthew Shoulders (Massachusetts Institute of Technology)

]]>
Other Mon, 04 Apr 2022 18:15:27 -0400 2022-04-04T16:00:00-04:00 2022-04-04T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
BioArtography - Call for Images (April 5, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742267@events.umich.edu Event Begins: Tuesday, April 5, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-05T00:00:00-04:00 2022-04-05T23:59:00-04:00 BioArtography Other U-M BioArtography
Environmental Injustice in the Southend of Dearborn (April 5, 2022 12:00pm) https://events.umich.edu/event/93452 93452-21704623@events.umich.edu Event Begins: Tuesday, April 5, 2022 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Registration required https://umich.zoom.us/webinar/register/WN_YhR24FAcQUm3sDY3FZmfwg

The next in the R&R series of talks featuring residents and researchers discussing the environment, health and community is "Environmental Injustice in the Southend of Dearborn".

Panelists include Samra'a Luqman, and environmental activist in the Southend of Dearborn and Zeina Reda, a University of Michigan student. Moderated by Natalie Sampson, Associate Professor of Health and Human Services, University of Michigan-Dearborn.

]]>
Lecture / Discussion Tue, 15 Mar 2022 13:53:19 -0400 2022-04-05T12:00:00-04:00 2022-04-05T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion R&R: Residents and Researchers Tuesday Talks at 12 on environment, health, and community
Incorporation and molecular level consequences of uridine mRNA modifications-Department of Biological Chemistry Seminar (April 5, 2022 12:00pm) https://events.umich.edu/event/92444 92444-21691559@events.umich.edu Event Begins: Tuesday, April 5, 2022 12:00pm
Location: Medical Science Unit I
Organized By: Biological Chemistry

Dr. Koutmou will present an in person seminar on 4/5/22 at 12:00 noon in room 5330 MS I

]]>
Workshop / Seminar Tue, 29 Mar 2022 10:34:07 -0400 2022-04-05T12:00:00-04:00 2022-04-05T13:00:00-04:00 Medical Science Unit I Biological Chemistry Workshop / Seminar Koutmou
‘Genetic mechanisms of pediatric renovascular hypertension’ (April 5, 2022 4:00pm) https://events.umich.edu/event/91188 91188-21677134@events.umich.edu Event Begins: Tuesday, April 5, 2022 4:00pm
Location: Off Campus Location
Organized By: Center for Cell Plasticity and Organ Design

The Center for Cell Plasticity and Organ Design is proud to present the following Cross Talk seminar with:

Dawn Marie Coleman, MD, FACS
Handleman Research Professor Associate Professor, Surgery and Pediatrics & Communicable Diseases
and
Santhi K. Ganesh, MD
Associate Professor, Cardiovascular Medicine,
Department of Internal Medicine, Department of Human Genetics

The Cross Talk is entitled, ‘Genetic mechanisms of pediatric renovascular hypertension.'

Moderator: Filip Bednar, MD, PhD, Surgery

For more information, please email: Organogenesis@umich.edu

]]>
Lecture / Discussion Sun, 20 Mar 2022 16:23:49 -0400 2022-04-05T16:00:00-04:00 2022-04-05T17:00:00-04:00 Off Campus Location Center for Cell Plasticity and Organ Design Lecture / Discussion flyer
Mini-Enzymes for Hydrogen Production and Small Molecule Activation (April 5, 2022 4:00pm) https://events.umich.edu/event/84372 84372-21623618@events.umich.edu Event Begins: Tuesday, April 5, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Inorganic
Kara Bren (University of Rochester)

]]>
Other Tue, 05 Apr 2022 18:15:24 -0400 2022-04-05T16:00:00-04:00 2022-04-05T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
BioArtography - Call for Images (April 6, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742268@events.umich.edu Event Begins: Wednesday, April 6, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-06T00:00:00-04:00 2022-04-06T23:59:00-04:00 BioArtography Other U-M BioArtography
Epithelial Oncogenic KRAS Drives Immunosuppression in Pancreatic Cancer (April 6, 2022 9:00am) https://events.umich.edu/event/93433 93433-21704488@events.umich.edu Event Begins: Wednesday, April 6, 2022 9:00am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

We are pleased to announce that Ashley Velez will present her Dissertation Defense on Epithelial Oncogenic KRAS Drives Immunosuppression in Pancreatic Cancer, on April 6, 2022, at 9:00 am in person at Kahn Auditorium (BSRB). and via live stream: Meeting Link: https://umich.zoom.us/j/94003848903 Passcode: KRAS

Hosted By the Dissertation Committee:
Marina Pasca di Magliano, Ph.D., Principal Investigator
Qing Li, MD, Ph.D., Chair
James Moon, Ph.D.
Timothy Frankel, M.D.
Howard Crawford, Ph.D.

]]>
Livestream / Virtual Tue, 15 Mar 2022 08:12:47 -0400 2022-04-06T09:00:00-04:00 2022-04-06T10:00:00-04:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Livestream / Virtual Epithelial Oncogenic KRAS Drives Immunosuppression in Pancreatic Cancer
Immunotherapeutic and Diagnostic Potential of Engineered Materials (April 6, 2022 2:00pm) https://events.umich.edu/event/94118 94118-21722028@events.umich.edu Event Begins: Wednesday, April 6, 2022 2:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Globally, breast cancer has the highest rates of incidence and mortality among women. For breast cancer diagnoses, while there is a 99% five-year relative survival rate for localized disease, survival drops to 29% for progression to metastatic disease. And, although robust advances have been made in the treatment of localized breast cancer, few therapies exist to effectively treat metastases. As such, distant spread marks the disease stage where treatment no longer has curative intent, and disease progression leads to mortality. The increased mortality with metastasis motivates the development of diagnostic and therapeutic strategies for managing metastatic disease, and I hypothesize that the microenvironment at the metastatic niche can serve as a target for these strategies.

First, I present a study investigating the utility of cargo-free PLGA nanoparticles (NPs) that, upon intravenous delivery, can be internalized by myeloid cells and subsequently alter their impact on the metastatic niche. We demonstrated that NPs reduce metastatic colonization of the lungs in a murine model of metastatic triple negative breast cancer (mTNBC). The NPs were found to modulate the immune microenvironment of the lungs, skewing myeloid cells toward inflammatory, anti-tumor phenotypes through single cell RNA sequencing. We then found that the reduction of metastatic spread was dependent on mature T-cells. Finally, NPs were administered in a primary tumor (PT) resection model and shown to lead to clearance of established metastatic lesions when delivered as an adjuvant therapy, following surgical resection.

The treatment of TNBC with immune checkpoint blockade (ICB) therapy, a T-cell targeted immunotherapy, has shown robust improvements in patient outcomes. However, while ICB-sensitive patients have durable responses to therapy, no effective biomarkers are available for predicting ICB-response and stratifying ICB-sensitivity from ICB-resistance. Our lab has previously shown that the immune milieu of a microporous PCL implant, which recapitulates key features of the native metastatic niche, can be longitudinally probed for monitoring 1) progression of cancer and 2) response to a PT resection. I investigate the hypothesis that the microporous implant can be longitudinally probed for ICB-response. Divergent responses in TNBC progression, as a result of anti-PD-1 administration, were identified and gene expression at the implant allowed for the ability to monitor ICB-response. Differential lymphocyte and myeloid cell responses were also identified that are correlative of the divergent responses to therapy. Finally, implant-derived gene expressions were probed prior to treatment to investigate predictive analytes for ICB-response before initiating therapy.

Overall, this dissertation demonstrates the potential for applying engineered materials to 1) modulate cancer-associated myeloid cells to enhance anti-tumor T-cell surveillance with the goal of clearing metastatic disease and 2) probe biomarkers to stratify ICB-response and investigate mechanisms underlying therapy resistance.

Date: Wednesday, April 6, 2022
Time: 2:00 PM EST
Zoom: https://umich.zoom.us/j/94478502873
Chair: Professor Lonnie D. Shea

]]>
Presentation Tue, 29 Mar 2022 13:19:30 -0400 2022-04-06T14:00:00-04:00 2022-04-06T15:00:00-04:00 Off Campus Location Biomedical Engineering Presentation BME Ph.D. Defense
BioArtography - Call for Images (April 7, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742269@events.umich.edu Event Begins: Thursday, April 7, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-07T00:00:00-04:00 2022-04-07T23:59:00-04:00 BioArtography Other U-M BioArtography
2022 Investigators Awards Launch Event (April 7, 2022 10:00am) https://events.umich.edu/event/92973 92973-21698652@events.umich.edu Event Begins: Thursday, April 7, 2022 10:00am
Location: Off Campus Location
Organized By: Precision Health

Join us for a lively, fast-paced series of presentations (3 minutes each!) by our most recently funded project PIs. Hear what exciting challenges they're taking on and see how multidisciplinary teams are working together to improve health.

After these presentations, we will open breakout rooms to invite your ideas on the following topics:
Tackling Health Disparities through Precision Health
New Advances in Health Image Analysis
Using Genetic Information to Individualize Patient Care
Reinforcement Learning & Causal Inference in Healthcare
Learning from Multi-institution EHR data Opportunities to Enhance Data Sharing and Collaboration
What's missing from Precision Health resources?

The launching projects include:
Anouck Girard (COE), Josephine Kasa-Vubu (Med), Michael DiPietro (Med) -- "Using Artificial Intelligence To Broaden and Diversify Outdated Standards for the Determination of Skeletal Maturation in Growing Children"

Todd Hollon (COE), Honglak Lee (COE), Sandra Camelo-Piragua (Med) -- "Rapid Intraoperative Molecular Diagnosis of Diffuse Gliomas Using Stimulated Raman Histology and Deep Neural Networks"

Hui Jiang (SPH) -- "Statistical and Computational Methods for Asymmetric Integration of Datasets from Different Cancers for the Identification of Cancer-related Genes and Biomarkers in Case-control Analyses"

Michael Mathis (Med) -- "Predicting Cardiac Surgery-Associated Acute Kidney Injury using Federated Learning"

Amy Pasternak (Pharm), Vaibhav Sahai (Med) -- "Assessing the Impact of Germline Pharmacogenetics (PGx) on Medication Outcomes and Clinician Prescribing Decisions in Patients with Cancer"

Scott Peltier (BME), Zhongming Liu (BME) -- "Deep Learning for Prediction of Mild Cognitive Impairment and Dementia of the Alzheimer’s Type"

Xu Shi (SPH) -- "Automated Harmonization of Multi-institutional Electronic Health Records Data"


Questions? Contact Tina Creguer, tcreguer@umich.edu.

]]>
Presentation Thu, 03 Mar 2022 16:52:49 -0500 2022-04-07T10:00:00-04:00 2022-04-07T11:30:00-04:00 Off Campus Location Precision Health Presentation Precision Health Investigators Awards
DCM&B Tools and Technology Seminar (April 7, 2022 12:00pm) https://events.umich.edu/event/89813 89813-21665891@events.umich.edu Event Begins: Thursday, April 7, 2022 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

]]>
Presentation Tue, 07 Dec 2021 09:11:01 -0500 2022-04-07T12:00:00-04:00 2022-04-07T13:00:00-04:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
Dynamical network models of the epileptic brain to improve surgical outcomes (April 7, 2022 3:30pm) https://events.umich.edu/event/94203 94203-21724114@events.umich.edu Event Begins: Thursday, April 7, 2022 3:30pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: Biomedical Engineering

Abstract:

Medically-refractory epilepsy (MRE) is a devastating neurological disease that is defined by recurrent and unprovoked seizures that are insufficiently controlled by anti-epileptic medication. If the seizures are originating from a specific region of the brain, surgical removal or stimulation of the epileptogenic region can be an effective therapy for these patients. The accurate localization of the seizure onset zone (SOZ) is critical for surgical success, but localizing the SOZ often requires implantation of intracranial EEG electrodes and continuous monitoring in the hospital for days to weeks so that seizures are recorded. Despite the longevity and invasiveness of this procedure, surgical success rates can be as low as 34%. In this talk, I will describe a study that aims to improve seizure onset localization and expedite the intracranial monitoring process by employing dynamical network models that investigate the patient’s epileptogenic network with recordings obtained during single-pulse electrical stimulation (SPES). We hypothesize that a dynamical quantification of the connectivity networks derived from the evoked responses induced by SPES could also be used to accurately localize the SOZ and guide clinicians in eliciting native seizures with electrical stimulation. I will give an overview of these dynamical network techniques and describe their potential impact in the clinical treatment of medically-refractory epilepsy.

Bio:

Rachel June Smith is a postdoctoral fellow in the Biomedical Engineering Department and Institute for Computational Medicine at Johns Hopkins University. She received her B.S. in Biomedical Engineering from the University of Tennessee, Knoxville, in 2014 and her M.S. and Ph.D. from UC Irvine in Biomedical Engineering in 2019. Her doctoral work focused on the development of computational metrics in scalp EEG data that reflected disease burden and predicted response to treatment in patients with infantile spasms. Currently, Rachel uses dynamical systems and control theory techniques to localize the onset of seizures in the epileptic brain. Rachel has been recently recognized for her work by the American Epilepsy Society where she won a 2020 Young Investigator Award and was named an AES Fellow.

Zoom Link: https://umich.zoom.us/j/96508834308

Organized by:

Dr. Brendon Baker,
Assistant Professor, Biomedical Engineering

Dr. David Nordsletten,
Associate Professor, Department of Biomedical Engineering and Cardiac Surgery

]]>
Workshop / Seminar Wed, 30 Mar 2022 15:27:55 -0400 2022-04-07T15:30:00-04:00 2022-04-07T16:30:00-04:00 Lurie Biomedical Engineering (formerly ATL) Biomedical Engineering Workshop / Seminar BME 500 Seminar
Chronic Traumatic Encephalopathy (CTE) and the Long-Term Consequences of Sports-Related Repetitive Head Impact Exposure: What We Know Now and What We Need to Know Next (April 7, 2022 4:00pm) https://events.umich.edu/event/93056 93056-21700220@events.umich.edu Event Begins: Thursday, April 7, 2022 4:00pm
Location: Off Campus Location
Organized By: Michigan Concussion Center

Robert Stern, professor of Neurology, Neurosurgery, and Anatomy & Neurobiology and fo-founder and director of Clinical Research at Boston University CTE Center, will present the neuropathological features of chronic traumatic encephalopathy (CTE), including what is currently known about risk factors for developing CTE; the clinical features associated with CTE and the NINDS Consensus Diagnostic Criteria for Traumatic Encephalopathy Syndrome; and the possible fluid and neuroimaging biomarkers for CTE.

]]>
Lecture / Discussion Mon, 07 Mar 2022 08:37:47 -0500 2022-04-07T16:00:00-04:00 2022-04-07T17:00:00-04:00 Off Campus Location Michigan Concussion Center Lecture / Discussion Robert Stern image and title on blue background with blue brain
EEB Thursday Virtual Seminar: Insect evolution, with a focus on Odonata (dragonflies and damselflies) (April 7, 2022 4:00pm) https://events.umich.edu/event/85738 85738-21628577@events.umich.edu Event Begins: Thursday, April 7, 2022 4:00pm
Location: Off Campus Location
Organized By: Ecology and Evolutionary Biology

Our weekly seminar series featuring internal and external speakers in the field of ecology and evolutionary biology.

Abstract
Dragonflies and damselflies, representing the insect order Odonata, are among the earliest flying insects with living (extant) representatives. However, unravelling details of their long evolutionary history, such as egg laying (oviposition) strategies, is impeded by unresolved phylogenetic relationships, an issue particularly prevalent in damselfly families and fossil lineages. Here we present the first transcriptome-based and AHE-based phylogenetic reconstructions of Odonata representing nearly all of the order’s families (except Austropetaliidae and Neopetaliidae). All damselfly families and most dragonfly families are recovered as monophyletic groups. Our Molecular clock estimates suggest that crown-Zygoptera (damselflies) and -Anisoptera (dragonflies) both arose during the late Triassic. Lastly, I briefly will review what we know about population structure in two groups of dragonflies, Neurocordulia and Pantala.

Brief biography
Jessica Ware is an associate curator in invertebrate zoology at the American Museum of Natural History. Dr. Ware’s research focuses on the evolution of behavioral and physiological adaptations in insects, with an emphasis on how these occur in Odonata (dragonflies and damselflies) and Dictyoptera (termites, cockroaches, and mantises). She holds a B.Sc. from the University of British Columbia in Canada, and a Ph.D. from Rutgers, New Brunswick. Ware is the past president of the Worldwide Dragonfly Association and serves as current president of the Entomological Society of America. She was recently awarded a PECASE medal from the U.S. government for her work on insect evolution.

See Zoom link this page

Image: Jessica Ware

]]>
Workshop / Seminar Tue, 05 Apr 2022 09:18:26 -0400 2022-04-07T16:00:00-04:00 2022-04-07T17:00:00-04:00 Off Campus Location Ecology and Evolutionary Biology Workshop / Seminar A dragonfly on a bag of lemons
BioArtography - Call for Images (April 8, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742270@events.umich.edu Event Begins: Friday, April 8, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-08T00:00:00-04:00 2022-04-08T23:59:00-04:00 BioArtography Other U-M BioArtography
17th Annual Early Career Scientists Symposium (April 8, 2022 12:00pm) https://events.umich.edu/event/89659 89659-21664742@events.umich.edu Event Begins: Friday, April 8, 2022 12:00pm
Location: Off Campus Location
Organized By: Ecology and Evolutionary Biology

The Department of Ecology and Evolutionary Biology (EEB) at the University of Michigan presents the 17th Annual Early Career Scientists Symposium: Racial Justice and Anti-Racist Research in EEB. We are delighted to announce that our featured speaker, Steward Pickett, distinguished urban ecologist from the Cary Institute and this year’s eminent ecologist of the Ecological Society of America, will open the symposium. A panel discussion led by Nicholas Reo, Associate Professor of Native American Studies at Dartmouth will bring the symposium to its conclusion.

Eight early career scholars who are transforming our discipline through anti-racist and justice-centered research that pushes our understanding of the links between EEB research and society, will present their perspectives in many areas of EEB, such as Global Environmental Change, Genomics and Population Genetics, Urban Ecology and Evolution, Environmental History, STEM Education, Marine Ecology, Water Security, Theoretical Ecology and Evolution, Global Food Systems, and Disease Ecology. The goal of this symposium is to provide a space for the EEB community to think imaginatively about the future of our discipline.

The symposium will begin on Saturday, March 19, 2022 (2 - 6 pm EDT) in-person and live-streamed, followed by three consecutive virtual Fridays (noon - 2 pm EDT) from March 25– April 8, 2022. Two to three participants will present each Friday, followed by a moderated discussion. For the symposium, we consider early career scientists as senior graduate students (who stand to receive their Ph.D. within two years), postdoctoral researchers, faculty or staff scientists within their first or second year, and researchers at equivalent career stages who are not affiliated with an academic institution.

While the symposium presents the work of rising early career scientists, it is open to all (i.e., you don’t have to be in your early career to attend).

Please contact the planning committee with questions: ecss-2022@umich.edu.

REGISTRATION is required for Zoom entry. You will be provided with the link and passcode upon registration. https://myumi.ch/ECSSregister

SPECIAL THANKS TO COSPONSORS CEW+ (Center for the Education of Women+) Irma M. Wyman Grant Program Fund and the Rackham Faculty Allies Diversity Grant!

Art by John Megahan based on a photo by Nick Reo. Kanaka Maoli and Anishinaabe land and language warriors visit and exchange knowledge at Hale O Kuhio, a structure erected in 2018 to assert the unfulfilled mandate of the Hawaiian Homes Commission Act of 1920.

]]>
Livestream / Virtual Fri, 04 Mar 2022 15:29:01 -0500 2022-04-08T12:00:00-04:00 2022-04-08T14:00:00-04:00 Off Campus Location Ecology and Evolutionary Biology Livestream / Virtual Art by John Megahan based on a photo by Nick Reo. Kanaka Maoli and Anishinaabe land and language warriors visit and exchange knowledge at Hale O Kuhio, a structure erected in 2018 to assert the unfulfilled mandate of the Hawaiian Homes Commission Act of 1920.
MCDB Seminar>CANCELED Shorter Visit CANCELED (April 8, 2022 12:00pm) https://events.umich.edu/event/90418 90418-21670792@events.umich.edu Event Begins: Friday, April 8, 2022 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

This seminar has been canceled.

]]>
Workshop / Seminar Mon, 28 Mar 2022 22:06:54 -0400 2022-04-08T12:00:00-04:00 2022-04-08T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow MCDB initials and microscope cartoon on blue background
BioArtography - Call for Images (April 9, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742271@events.umich.edu Event Begins: Saturday, April 9, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-09T00:00:00-04:00 2022-04-09T23:59:00-04:00 BioArtography Other U-M BioArtography
BioArtography - Call for Images (April 10, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742272@events.umich.edu Event Begins: Sunday, April 10, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-10T00:00:00-04:00 2022-04-10T23:59:00-04:00 BioArtography Other U-M BioArtography
BioArtography - Call for Images (April 11, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742273@events.umich.edu Event Begins: Monday, April 11, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-11T00:00:00-04:00 2022-04-11T23:59:00-04:00 BioArtography Other U-M BioArtography
LSI SciComm Speaker Series: Matt Richtel (April 11, 2022 10:00am) https://events.umich.edu/event/92899 92899-21697950@events.umich.edu Event Begins: Monday, April 11, 2022 10:00am
Location: Palmer Commons
Organized By: Life Sciences Institute (LSI)

* The LSI's SciComm Speaker Series highlights the importance of disseminating scientific findings beyond the walls of the academy and effectively communicating the impact of publicly-funded research. This annual event provides world-leading science writers and communicators with an opportunity to share their experiences with faculty, staff and students, while also tapping into U-M's vast scientific research community. This year's speaker is best-selling author and Pulitzer Prize-winning reporter Matt Richtel.*

In 2019, Richtel's book about the immune system, An Elegant Defense, hit shelves. Richtel steeped the book in deep science, but covered all that deep science in frosting: story, anecdote and humor. When the book came out, the New York Times published an excerpt. What chapter did they choose? The one that asked: Should you pick your nose? Richtel had asked the question as a way of exploring whether our urge to probe our noses is actually a way for evolution to sneak some outside information to our immune systems. While we may not have a definitive answer to that question, after more than two decades at the New York Times and as author of several best-of-the-year science books, Richtel does know the answer to this: How do you make science information palatable? What does it take to educate the public?

There are two answers: One is story. The second is existential crisis. When Covid hit, the public started paying attention to science as never before. But this talk about the former—how to turn science into a story that people are eager to consume and that they will remember.

Over the course of this conversation, Richtel will offer specific examples of how he has married complicated science with compelling stories without sacrificing the sanctity and complexity of the research and scholarship. He will also tackle a number of specific, key issues around the marriage of science and storytelling: ethics, the role of the scientist/scholar, the relationship between scientist and journalist and how to improve it; the responsibility of media to understand how to read science, and accurately calibrate its weight. Plus, all the questions you want to ask!

*Coffee and light refreshments will be offered beginning at 9:30. Richtel will be available to sign books and bookplates immediately following the event.*

About the Speaker:
Matt Richtel is a Pulitzer Prize-winning reporter for The New York Times, lauded speaker and bestselling author. He writes about technology, its impact on society, and how it changes the way we work, play and relate to each other. In 2010 he won the Pulitzer Prize for National Reporting for his series of articles on the hazardous use of cell phones, computers and other devices while driving. Richtel lives in San Francisco with his wife and their two children. He is an avid tennis player, a recreational athlete, a prideful maker of guacamole for parties and a periodic (and not good) songwriter. He grew up in Boulder, Colorado, the son of two avid readers, attended Boulder High School, and obtained a bachelor’s degree in rhetoric from University of California at Berkeley and a master's degree in journalism from Columbia University.

]]>
Lecture / Discussion Tue, 29 Mar 2022 08:05:21 -0400 2022-04-11T10:00:00-04:00 2022-04-11T11:00:00-04:00 Palmer Commons Life Sciences Institute (LSI) Lecture / Discussion LSI SciComm Speaker Series: Matt Richtel, Author and Reporter
Metal Oxo Clusters in Oxidation Chemistry and Water-Splitting Catalysis (April 11, 2022 4:00pm) https://events.umich.edu/event/91343 91343-21678332@events.umich.edu Event Begins: Monday, April 11, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

The conversion of solar energy into a useful chemical fuel represents a major scientific goal in the drive towards a society powered by renewable energy. Several potential solar fuels seem possible, including hydrogen from proton reduction, or hydrocarbons from the reduction of carbon dioxide. Useful rates of solar fuel production must rely on an efficient oxidation that generates electrons and protons. In nature's photosynthesis, this is accomplished by a tetra-manganese oxo cluster (the oxygen-evolving complex, OEC), which yields 4 protons and 4 electrons by the photo-oxidation of water (the oxygen evolution reaction, OER). For solar fuel applications this water-splitting half reaction must be catalyzed to make it energetically feasible, and transition-metal oxo cubane clusters related to the OEC represent intriguing model systems and design motifs for new water-splitting catalysts based on abundant metals. Molecularly derived catalysts of this type offer potential advantages, including the synthetic tunability of catalytic and chemical properties. In addition, the study of high-valent molecular species can provide key insights into the mechanism of water oxidation and help bridge the gap between solid-state and molecular systems to allow for more rational design of catalysts. This presentation will describe high-valent metal complexes and clusters, and a detailed mechanism for the evolution of oxygen via water oxidation at a tetranuclear cobalt oxo cubane. An important aspect to this catalysis relates to the manner in which metals cooperate to mediate multi-electron, multi-proton oxidations. In further pursuit of these concepts, the synthesis and study of related heterometallic oxo clusters have been targeted.

Don Tilley (University of Caifornia, Berkeley)

]]>
Other Mon, 11 Apr 2022 18:15:26 -0400 2022-04-11T16:00:00-04:00 2022-04-11T17:30:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
RNA Innovation Seminar: "Alternative structures of the SARS-CoV-2 RNA genome control gene expression and offer therapeutic strategies" (April 11, 2022 4:00pm) https://events.umich.edu/event/92832 92832-21697177@events.umich.edu Event Begins: Monday, April 11, 2022 4:00pm
Location: Off Campus Location
Organized By: Center for RNA Biomedicine

VIrtual Seminar: https://umich.zoom.us/webinar/register/WN_zi3UlKucR6G51hEA_33Exg

If you are having trouble registering, please contact Martina Jerant at mjerant@umich.edu

]]>
Lecture / Discussion Fri, 01 Apr 2022 17:40:01 -0400 2022-04-11T16:00:00-04:00 2022-04-11T17:00:00-04:00 Off Campus Location Center for RNA Biomedicine Lecture / Discussion Silvi Rouskin, Ph.D., Harvard Medical School
BioArtography - Call for Images (April 12, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742274@events.umich.edu Event Begins: Tuesday, April 12, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-12T00:00:00-04:00 2022-04-12T23:59:00-04:00 BioArtography Other U-M BioArtography
Nickel-Mediated Radical Pathways and Applications to Peptide Modification (April 12, 2022 11:00am) https://events.umich.edu/event/94329 94329-21734377@events.umich.edu Event Begins: Tuesday, April 12, 2022 11:00am
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Reactions involving organic radical intermediates have been traditionally regarded as overly reactive and unselective. Nickel complexes can mediate reactions involving radicals by forming metallo-radical intermediates, and thus modulate the reactivity and control the selectivity. We apply organometallic and physical organic techniques to characterize fundamental steps involved in nickel-catalyzed cross-coupling reactions, including radical generation, chain propagation, termination, and C–C bond formation. Mechanistic insight has informed us in the development of an enantioselective method to modify peptides. The reaction provides a convenient means to access non-canonical peptides that could serve as pharmaceutical targets.
Tianning Diao (New York University)

]]>
Other Tue, 12 Apr 2022 18:15:17 -0400 2022-04-12T11:00:00-04:00 2022-04-12T12:00:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
A Detailed Look at Tail-Anchored Membrane Protein Targeting-From Opisthokonts to Protists to Plans- Department of Biological Chemistry Martha Ludwig Lectureship (April 12, 2022 12:00pm) https://events.umich.edu/event/92445 92445-21691563@events.umich.edu Event Begins: Tuesday, April 12, 2022 12:00pm
Location: Medical Science Unit I
Organized By: Biological Chemistry

Dr. Bil Clemons will give an in person seminar on Tuesday 4/12/2022 at 12:00 noon in 5330 MS I.

]]>
Workshop / Seminar Wed, 16 Feb 2022 12:55:15 -0500 2022-04-12T12:00:00-04:00 2022-04-12T13:00:00-04:00 Medical Science Unit I Biological Chemistry Workshop / Seminar Clemons
“How your cilia communicate intercellular signaling?" (April 12, 2022 4:00pm) https://events.umich.edu/event/90536 90536-21671501@events.umich.edu Event Begins: Tuesday, April 12, 2022 4:00pm
Location: Off Campus Location
Organized By: Center for Cell Plasticity and Organ Design

The Center for Cell Plasticity and Organ Design is proud to present the following seminar speaker:
Jeremy Reiter, MD, PhD
Professor & Chair, Department of Biochemistry and Biophysics
University of California, San Francisco


The talk is entitled, “How your cilia communicate intercellular signaling."

Public Seminar: 4-5 p.m. Zoom: https://umich.zoom.us/j/98790098902

Faculty Host: Sunny Wong, PhD, Department of Dermatology

For more info email: Organogenesis@umich.edu

]]>
Lecture / Discussion Thu, 24 Mar 2022 16:20:19 -0400 2022-04-12T16:00:00-04:00 2022-04-12T17:00:00-04:00 Off Campus Location Center for Cell Plasticity and Organ Design Lecture / Discussion JR Flyer
Capture and Release of Metals of Energy Importance Using Redox-Switchable Carboranes (April 12, 2022 4:00pm) https://events.umich.edu/event/90378 90378-21670539@events.umich.edu Event Begins: Tuesday, April 12, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Department of Chemistry

Inorganic
Gabriel Menard (UC Santa Barbara)

]]>
Other Tue, 12 Apr 2022 18:15:17 -0400 2022-04-12T16:00:00-04:00 2022-04-12T17:15:00-04:00 Chemistry Dow Lab Department of Chemistry Other Chemistry Dow Lab
Functional MRI 2021-22 Speaker Series with Katharine Thakkar, Ph.D. (April 12, 2022 4:00pm) https://events.umich.edu/event/93931 93931-21710805@events.umich.edu Event Begins: Tuesday, April 12, 2022 4:00pm
Location: Chemistry Dow Lab
Organized By: Functional MRI Lab

Abstract:

The ability to make rapid behavioral adjustments is critical in a dynamic environment, and impaired action control is associated with several neuropsychiatric disorders, including schizophrenia. Rapid action modification and cancellation has been investigated using the stop-signal task and related paradigms. These paradigms require a fast response to a movement cue unless a subsequent signal is presented that instructs participants to inhibit or change the planned movement. Performance on these tasks is modeled as a race between competing STOP and GO processes, which permits an estimation of the time it takes to stop a prepared action—stop-signal reaction time. Using oculomotor versions of such tasks, nonhuman primate studies have investigated the cellular basis of reactive action control and performance monitoring. This body of neurophysiology work provides a firm basis from which to understand the brain circuits supporting reactive action control in humans. In this talk, I will present work that uses fMRI to examine the network involved in rapid cancellation, modification, and monitoring of gaze in humans. In addition, I will present a series of studies indicating reduced efficiency of action cancellation in individuals with schizophrenia that are related to symptoms and functional outcomes and more recent work demonstrating altered activation in a frontobasal network in individuals with schizophrenia while performing a modified oculomotor stop-signal task. Combined, this work provides a link between mechanisms of action control in humans and non-human primates and insights into potential mechanisms of inefficient action control in individuals with schizophrenia.

You can attend in person: 4 p.m. Chemistry & Dow Willard H Laboratory (Central Campus), Room 1300.

You can attend via Zoom: https://umich.zoom.us/j/91394388153,
passcode: 892467

]]>
Lecture / Discussion Thu, 24 Mar 2022 07:28:12 -0400 2022-04-12T16:00:00-04:00 2022-04-12T17:30:00-04:00 Chemistry Dow Lab Functional MRI Lab Lecture / Discussion Katharine Thakkar, Ph.D.
BioArtography - Call for Images (April 13, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742275@events.umich.edu Event Begins: Wednesday, April 13, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-13T00:00:00-04:00 2022-04-13T23:59:00-04:00 BioArtography Other U-M BioArtography
New insights into the regulation of energy homeostasis (April 13, 2022 9:30am) https://events.umich.edu/event/92909 92909-21698063@events.umich.edu Event Begins: Wednesday, April 13, 2022 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: Cell & Developmental Biology

CDB 2022 Seminar Series:

We are pleased to welcome Alan Robert Saltiel, Ph.D. to the Kahn Auditorium in BSRB on April 13, 2022, to present his talk titled "New insights into the regulation of energy homeostasis"!

In-Person & Virtual
Zoom Meeting link: https://umich.zoom.us/j/97387165812

Hosted By:
Doug Engel, Ph.D. Cell and Developmental Biology
Scott Soleimanpour, M.D., Caswell Diabetes Institute (CDI)

]]>
Lecture / Discussion Fri, 11 Mar 2022 12:15:06 -0500 2022-04-13T09:30:00-04:00 2022-04-13T10:30:00-04:00 Taubman Biomedical Science Research Building Cell & Developmental Biology Lecture / Discussion New insights into the regulation of energy homeostasis
UM/Agilent Measurement Symposium (April 13, 2022 5:00pm) https://events.umich.edu/event/85162 85162-21625673@events.umich.edu Event Begins: Wednesday, April 13, 2022 5:00pm
Location: Off Campus Location
Organized By: Department of Chemistry

Analytical

]]>
Other Mon, 21 Mar 2022 12:15:27 -0400 2022-04-13T17:00:00-04:00 2022-04-13T20:45:00-04:00 Off Campus Location Department of Chemistry Other
BioArtography - Call for Images (April 14, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742276@events.umich.edu Event Begins: Thursday, April 14, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-14T00:00:00-04:00 2022-04-14T23:59:00-04:00 BioArtography Other U-M BioArtography
UM Agilent Measurement Symposium (April 14, 2022 9:00am) https://events.umich.edu/event/85072 85072-21625546@events.umich.edu Event Begins: Thursday, April 14, 2022 9:00am
Location: Weiser Hall
Organized By: Department of Chemistry

Analytical
David Russell(TAMU) , Susan Olesik(Ohio State University) , John Fjeldsted(Agilent) , Darlene Solomon(Agilent)

]]>
Other Thu, 14 Apr 2022 18:15:24 -0400 2022-04-14T09:00:00-04:00 2022-04-14T17:00:00-04:00 Weiser Hall Department of Chemistry Other Weiser Hall
Cellular Mechanisms of Lip and Primary Palate Fusion (April 14, 2022 12:00pm) https://events.umich.edu/event/94366 94366-21735840@events.umich.edu Event Begins: Thursday, April 14, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

A. Personal Statement

Highlighted publications:

Lewis A.E., Kuwahara A., Franzosi J., Bush, J.O.* (2022) Tracheal separation is driven by NKX2-1-mediated repression of Efnb2 and regulation of endodermal cell sorting. Cell Reports, 38(11):110510

Kindberg A.A., Srivastava, V., Muncie, J.M., Weaver V.M., Gartner, Z.J. and Bush, J.O.* (2021). EPH/EPHRIN regulates cellular organization by actomyosin contractility effects on cell contacts Journal of Cell Biology 220 (6): e202005216 PMCID: PMC8025214

Kuwahara, A., Lewis, A., Coombes, C., Leung, F.S., Percharde M., Bush J.O.* (2020) Delineating the early transcriptional specification of the mammalian trachea and esophagus. eLife, 9:e55526 PMCID: PMC7282815

Niethamer, T. K., Teng, T., Franco, M., Du, Y. X., Percival, C. J., Bush, J.O.* (2020). Aberrant cell segregation in the craniofacial primordium and the emergence of facial dysmorphology in craniofrontonasal syndrome. PLoS Genet. 16, e1008300.

Highlighted projects:
R35 DE031926-01 (PI: Bush) 4/1/2022-3/31/2030
NIH/NIDCR
Signaling control and cellular basis of craniofacial morphogenesis and congenital disease

R01 DE023337 (PI: Bush) 7/9/2013-3/31/2022
NIH/NIDCR
Mechanisms of Eph/Ephrin signaling in craniofacial morphogenesis and craniofrontonasal syndrome

R01DE028753 (PI: Selleri) 4/1/2019-3/31/2024
NIH/NIDCR
Phenotype-driven approach to understanding the function of craniofacial regulators using IMPC-generated mouse strains

UG3DE028872 (PI: Klein) 7/1/2019-6/30/2024
NIH/NIDCR
“Enamel atlas: systems-level amelogenesis tools at multiple scales”

B. Positions, Scientific Appointments and Honors
Positions and Employment:
2019-present Vice Chair, Department of Cell and Tissue Biology
2021-present Professor, Department of Cell and Tissue Biology and Program in Craniofacial Biology, University of California at San Francisco
2017-2021 Associate Professor, Department of Cell and Tissue Biology and Program in Craniofacial
Biology, University of California at San Francisco
2011-2017 Assistant Professor, Department of Cell and Tissue Biology and Program in
Craniofacial Biology, University of California at San Francisco
2005-2011 Postdoctoral research at FHCRC/MSSM
Advisor: Dr. Philippe Soriano
1999-2005 Graduate and postdoctoral research at University of Rochester
Advisor: Dr. Rulang Jiang

Awards and Honors:
2021 Marylou Buyse Distinguished Scientist in Craniofacial Research award from the Society for Craniofacial Genetics and Developmental Biology
2019 F1000 Faculty member for Developmental Biology
2019 David W. Smith workshop on malformations and morphogenesis keynote
2014 American Association of Anatomists Young Faculty Travel Award
2010-present F1000/F1000Prime has featured and highly ranked five of our publications
2010 NIH pathway to independence award from NIH/NIDCR K99/R00 (DE020855)
2006-2008 Ruth L Kirschstein NRSA Individual Fellowship from NIH/NIDCR F32 (DE17506)
2005 Basil Bibby award from the AADR
2004 Michael G. Buonocore award from the AADR

Other Experience and Professional Memberships
2021-2025 Member NIH Skeletal Biology Development and Disease (SBDD)
2021 Cold Spring Harbor Labs Mouse Engineering Course lecturer and workshop leader
2021 American Association of Anatomists Program Committee
2020 Ad hoc reviewer NIH/NIDCR SEP ZDE1 Endogenous Regeneration of Dental, Oral and Craniofacial Tissue
2020 Ad hoc reviewer NIH CSR ZRG1 Fellowships: Cell Biology, Developmental Biology and Bioengineering
2020 Ad hoc reviewer Czech Science Foundation
2019 Ad hoc reviewer for NIH Skeletal Biology Development and Disease (SBDD)
2017 Ad hoc reviewer for NIH on Microphysiological Systems (MPS) for Disease Modeling and Efficacy Testing (UG3/UH3) “Tissue Chips and Disease Modeling”
2017-present International Association for Dental Research
2017 Guest Editor, Developmental Biology, special issue on signaling in development
2014 Ad hoc reviewer for NIH on SEP ZRG1 MOSS-D (02), “Bone, Cartilage and Tendon”
2013, 2014 Invited peer reviewer for UK MRC
2012 Ad hoc reviewer for NIH on Council ZES1, “Environmental influences on stem cells in development, health and disease”
2012 Organizer, session chair, Society of Craniofacial Genetics Annual Meeting, San Francisco, CA
2012-present Member, Society for Craniofacial Genetics and Development
2010-present Member, American Association of Anatomists
2000-present Member, Society for Developmental Biology
Ad hoc Reviewer for Development, Developmental Biology, Developmental Dynamics, Journal of Dental Research, Genesis, Immunobiology, Journal of Cell Biology, Science, PLOS Genetics, Immunobiology, PLOS One, Developmental Cell, PLOS Biology, Human Molecular Genetics, JOVE

C. Contributions to Science
1. Identified Eph/ephrin cellular mechanisms in morphogenesis
We have made major contributions to understanding EPH/EPHRIN signaling mechanisms in development in multiple contexts including the craniofacial, neural and neural crest systems. The EPHs compose the largest family of receptor tyrosine kinases in the vertebrate genome constituting one quarter of the total number. Though extensively studied in the nervous system, the signaling mechanisms utilized by this family in other contexts are complex and modestly understood, particularly in vivo. We have learned that a large number of these molecules exhibit distinct expression patterns in the developing craniofacial region. In a novel “conditional-rescue” approach we discovered that EPHRIN-B2 is required in the vascular endothelium for normal NCC development. EPH/EPHRIN signaling is widely known to regulate cellular organization, but the signaling mechanisms by which it does so are unclear. By studying a series of targeted and signaling mutations in EPHRIN-B1 and its receptors EPHB2 and EPHB3 in mice, we determined that EPH/EPHRIN cell segregation involves unidirectional forward signaling from EPHRIN-B1 and relies on kinase activity of the receptors. By live cell imaging we also observe that this unidirectional signaling results in changes in cortical actomyosin accumulation and leading us to interrogate the biophysical basis for EPH/EPHRIN cell segregation. We recently discovered that EPH/EPHRIN signaling modulates the strength of cell-cell contacts by regulating cell interfacial tension through increased heterotypic cortical actomyosin contractility. The minimization of heterotypic interfacial tension also informs how EPH/EPHRIN signaling regulates tissue shape changes relevant to Contributions number 2 and 4. Current efforts in this area focus on how EPH/EPHRIN signaling regulates mesenchymal cell polarity and cell position, forming the basis for part of “Focus one” of this proposal.

Agrawal, P., Wang, M., Kim, S., Lewis, A.E., Bush, J.O.* (2014) The embryonic expression of EphA receptor genes in mice supports their candidacy for involvement in cleft lip and palate. Developmental Dynamics, 243 (11): 1470-6. PMCID: PMC4404412
Lewis, A.E., Hwa, J., Wang, R., Soriano P., Bush, J.O.* (2015) Neural crest defects in ephrin-B2 mutant mice are non-autonomous and originate from defects in the vasculature. Developmental Biology, 406(2): 186-95. PMCID: PMC4639416
O’Neill, A.O., Kindberg, A.A., Niethamer, T.K. Larson, A.R., Ho, H.H., Greenberg, M.E., Bush, J.O.* (2016) Unidirectional Eph/ephrin signaling creates a cortical actomyosin differential to drive cell segregation. Journal of Cell Biology, 215 (2): 217 PMCID: PMC5984648
Kindberg A.A., Srivastava, V., Muncie, J.M., Weaver V.M., Gartner, Z.J. and Bush, J.O.* (2021). EPH/EPHRIN regulates cellular organization by actomyosin contractility effects on cell contacts Journal of Cell Biology 220 (6): e202005216 PMCID: PMC8025214

2. Delineated Eph/ephrin signaling mechanisms underlying craniofrontonasal syndrome
We have focused on the role of EPH/EPHRIN signaling in craniofrontonasal syndrome (CFNS), an X-linked condition caused by mutations in EFNB1 characterized by hypertelorism, craniosynostosis, cleft lip and palate, agenesis of the corpus callosum, and particularly increased severity in female patients. By generating a series of signaling mutations in three different gene targeted mouse lines, we were able to determine the relevant modes of signaling for different EPHRIN-B1 phenotypes. We found that reverse signaling by a PDZ-dependent mechanism is critical for axon guidance, whereas it is dispensible for skeletal and craniofacial development. This work showed that different aspects of craniofrontonasal syndrome are caused by loss of function of distinct molecular EPHRIN-B1 signaling functions. Further, by integrating mouse genetics, phosphoproteomic and transcriptomic approaches we have investigated downstream signaling pathways utilized by EPHRIN-B1 in craniofacial development and disease. In this context, we were the first to show that EPH receptor expression is regulated by endocytosis in vivo, and that EPHRIN-B1 controls cell proliferation by the Ras/MAPK signaling pathway. We have also generated an hiPSC model for CFNS, which to our knowledge is the first hiPSC model of a congenital craniofacial syndrome, and used to it ask key questions about the cellular etiology underlying this perplexing disease. Recently, we coupled geometric morphometric techniques with temporal and spatial manipulation of EPHRIN-B1 signaling to elucidate how Efnb1 mutations result in stereotyped dysmorphology in CFNS. Current efforts in this area focus on delineating the proximal signal transduction mechanisms employed by EPH/EPHRIN-B1 signaling in craniofacial morphogenesis using CRISPR/CAS9 based methods.

Bush, J. O. and Soriano, P. (2010). Ephrin-B1 forward signaling regulates craniofacial morphogenesis by controlling cell proliferation across Eph-ephrin boundaries. Genes Dev. 24, 2048-60. PMCID: PMC2939368
Niethamer, T.K., Larson, A.R., O’Neill A.K., Bershteyn, M., Hsiao, E.C., Klein, O.D., Pomerantz, J.H., Bush J.O.* (2017) EPHRIN-B1 mosaicism drives cell segregation in craniofrontonasal syndrome hiPSC-derived neuroepithelial cells. Stem Cell Reports, 8(3): 529-537. PMCID: PMC5355632
Niethamer, T. K. and Bush, J. O.* (2019). Getting direction(s): The Eph/ephrin signaling system in cell positioning. Dev. Biol. 447, 42–57.
Niethamer, T. K., Teng, T., Franco, M., Du, Y. X., Percival, C. J., Bush, J. O. (2020). Aberrant cell segregation in the craniofacial primordium and the emergence of facial dysmorphology in craniofrontonasal syndrome. PLoS Genet. 16, e1008300.

3. Developed live imaging approaches to discover cellular mechanisms of craniofacial tissue fusions
Though tissue fusion is a critical final step of lip and palate development, we currently lack cellular resolution understanding of how these tissue fusion events occur, and how they are controlled. We have been examining the cellular and molecular mechanisms by which tissue fusion occurs by combining live imaging of mouse morphogenesis with mouse genetic and physical perturbations. We developed the first successful application of confocal live imaging technology to secondary palate development, and it has allowed us to make new discoveries on the cellular mechanisms at play. Our results indicate that tissue fusion proceeds by a progression of dynamic cell behaviors beginning with convergence of two independent epithelia and concomitant to orthogonal displacement of the resultant shared epithelium. Further, we have found that epithelial cell extrusion, in which cells are squeezed out of an epithelium, is a novel contributor to the removal of the midline epithelial seam (MES). A nearly completed manuscript presents a new live imaging approach to understanding secondary palate fusion, and demonstrates a unique and novel form of collective epithelial migration that is crucial for this process. Most recently, we have also established live imaging approaches for the study of upper lip/primary palate fusion, which we are using to study roles for actomyosin contractility and cell adhesion in this process.

Bush J.O.*, Jiang R.* (2012) Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development. Development. 139(2):231-43. PMCID: PMC3243091
Kim, S., Lewis A.E., Singh V., Ma, X., Adelstein, R., Bush, J.O.,* (2015) Convergence and extrusion are required for normal fusion of the mammalian secondary palate. PLOS Biology, 13(4) PMCID: 4388528
Kim S., Prochazka, J., Bush J.O.*, (2017) Live imaging of Mouse Secondary Palate Fusion. JoVE. July 2017 (125) PMCID: In process

4. Improved mouse genetics tools for the study of craniofacial and neural crest development and disease
In the course of our studies, we discovered that the Wnt1-Cre mouse line exhibits developmental phenotypes attributable to elevated and ectopic activation of Wnt signaling. This is a standard and widely used reagent in the fields of craniofacial development and neural crest stem cell biology and our careful analysis of this reagent has already had broad-reaching effects causing labs to re-examine previously published work. To provide a reagent that is devoid of these complications, we generated a Wnt1-Cre2 transgenic mouse line that exhibits the same pattern of activity as Wnt1-Cre but does not cause ectopic activation of Wnt signaling or developmental phenotypes. Over the past five years, I have also served as the faculty advisor for the UCSF mouse inventory database, which facilitates the sharing of genetically modified mouse lines. Most recently, my lab has successfully adopted the iGONAD electroporation method for rapid generation of new mouse lines which we are employing to generate new mouse models for the study of congenital disease.

Lewis, A., Vasudevan, H., O’Neill, A., Soriano, P., Bush, J.O.* (2013) The widely used Wnt1-Cre transgene causes developmental phenotypes by ectopic activation of Wnt signaling. Developmental Biology, 379(2):229-34. PMCID: PMC3804302
Wall, E., Scoles, J., Joo, A., Klein, O., Quinonez, C., Bush, J. O., Martin, G. R. and Laird, D. J. (2020). The UCSF Mouse Inventory Database Application, an Open-Source Web App for Sharing Mutant Mice within a Research Community. G3 (Bethesda).

5. Understanding how cell fate and morphogenesis are coupled in the developing foregut
Based initially on phenotypes that we discovered in an Efnb2 mutant mouse line that we generated, we have now established a robust research focus on understanding the specification and morphogenesis of the trachea and esophagus. Classical developmental biology experiments hypothesize that two transcription factors, NKX2.1 and SOX2 act as master regulators of these fates, but this remains untested at the transcriptome level and their targets were unknown. we combine state-of-the-art transcriptomic experiments in embryonic tissues with functional mouse genetic experiments to expose the fundamental process of fate specification of the trachea and esophagus. We performed single cell RNA sequencing in mice to establish a transcriptome-wide understanding of the early steps of trachea and esophagus development and used these data, combined with RNA-sequencing of mutants and embryonic ChIP-seq to interrogate the transcriptome-wide function of NKX2.1 in tracheal and esophageal development. The results of these experiments provide a new understanding of how the trachea and esophagus are initially specified at the genome-wide level. Our studies also reveal that NKX2.1 directly represses Efnb2 to regulate the site of tracheoesophageal separation. These discoveries may be impactful to the study of tracheal, lung, and esophageal developmental biology and related structural anomalies in humans, as well as for the fields of embryonic stem cell biology and for lung and esophageal cancer for which these are keystone transcriptional pathways.

Kuwahara, A., Lewis, A., Coombes, C., Leung, F.S., Percharde M., Bush J.O.* (2020) Delineating the early transcriptional specification of the mammalian trachea and esophagus. eLife, 9:e55526 PMCID: PMC7282815
Lewis A.E., Kuwahara A., Franzosi J., Bush, J.O.* (2022) Tracheal separation is driven by NKX2-1-mediated repression of Efnb2 and regulation of endodermal cell sorting. Cell Reports, 38(11):110510

]]>
Lecture / Discussion Tue, 05 Apr 2022 10:39:07 -0400 2022-04-14T12:00:00-04:00 2022-04-14T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Lecture / Discussion Jeffrey Bush Professor and Vice Chair, Department of Cell and Tissue Biology and Program in Craniofacial Biology
DCM&B Tools and Technology Seminar (April 14, 2022 12:00pm) https://events.umich.edu/event/89814 89814-21665892@events.umich.edu Event Begins: Thursday, April 14, 2022 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

]]>
Presentation Fri, 25 Mar 2022 10:41:08 -0400 2022-04-14T12:00:00-04:00 2022-04-14T13:00:00-04:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
EEB Thursday Seminar: How (and why) to get a tenure-track job at a non research-1 university (April 14, 2022 4:00pm) https://events.umich.edu/event/86330 86330-21632730@events.umich.edu Event Begins: Thursday, April 14, 2022 4:00pm
Location: Biological Sciences Building
Organized By: Ecology and Evolutionary Biology

Our weekly seminar series featuring internal and external speakers in the field of ecology and evolutionary biology. This seminar will be in-person and livestreaming on Zoom (link this page).

Abstract
Many Ph.D. students and postdocs at Research-1 (R1) universities are interested in exploring academic careers at non-academic universities, including liberal arts colleges and master's-granting universities. However, resources on how to prepare to be competitive in applications for job openings may be scarce at R1 universities because advising faculty are most familiar with preparation for applying for R1 jobs. I am a professor of biological sciences at a public, master's-granting institution where I have served on numerous tenure-track faculty search committees over the past 18 years. In this presentation, I give attendees practical advice on how to prepare to apply for tenure-track jobs at non-R1 universities, including important experience they should have, how to write the cover letter, teaching statement, research statement, and diversity statement, and advice for phone and on-campus interviews. Though the talk is geared toward graduate students and postdocs, faculty are welcome to attend so that they can better advise students interested in non-R1 jobs.

Image credit: Brittany App

]]>
Workshop / Seminar Wed, 13 Apr 2022 15:45:55 -0400 2022-04-14T16:00:00-04:00 2022-04-14T17:00:00-04:00 Biological Sciences Building Ecology and Evolutionary Biology Workshop / Seminar Emily Taylor showing students a snake on a class field trip
Shaomeng Wang Drug Discovery Award Lecture (April 14, 2022 4:00pm) https://events.umich.edu/event/94455 94455-21739821@events.umich.edu Event Begins: Thursday, April 14, 2022 4:00pm
Location: Palmer Commons
Organized By: U-M College of Pharmacy

The Univeristy of Michigan College of Pharmacy is pleased to announce the first Shaomeng Wang Drug Discovery Award Lecture: “Chemical Strategies for Drugging the Undruggable, from KRAS to p53,” presented by Kevan M. Shokat, PhD, Professor, Department of Cellular and Molecular Pharmacology, UCSF; Professor, Department of Chemistry, UC Berkeley; Investigator, Howard Hughes Medical Institute.

Kevan M. Shokat received his B.A. in Chemistry from Reed College in 1986, his Ph.D. in organic chemistry at UC Berkeley with Professor Peter Schultz and carried out post-doctoral work in cellular immunology at Stanford University with Professor Chris Goodnow. Kevan’s research group is focused on the discovery of new small molecule tools and drug candidates targeting protein/lipid kinases, GTPases, and RNA helicases. His laboratory utilizes the tools of synthetic organic chemistry, protein engineering, structural biology, biochemistry and cell biology. He was inducted into the National Academy of Sciences (2010), the National Academy of Medicine (2011), and the American Academy of Arts and Sciences (2011). He has commercialized discoveries from his laboratory through co-founding several biotechnology companies including Intellikine, Araxes, Wellspring Biosciences, Kura Oncology, eFFECTOR Therapeutics, Mitokinin, Revolution Medicines, Erasca and Kumquat Biosciences.

]]>
Lecture / Discussion Thu, 07 Apr 2022 09:02:06 -0400 2022-04-14T16:00:00-04:00 2022-04-14T17:00:00-04:00 Palmer Commons U-M College of Pharmacy Lecture / Discussion Shaomeng Wang Drug Discovery Award Lecture
BioArtography - Call for Images (April 15, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742277@events.umich.edu Event Begins: Friday, April 15, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-15T00:00:00-04:00 2022-04-15T23:59:00-04:00 BioArtography Other U-M BioArtography
U-M Structure Seminar: "Size doesn't matter: de novo generation of llama-derived nanobodies for biological research" (April 15, 2022 10:00am) https://events.umich.edu/event/90345 90345-21670437@events.umich.edu Event Begins: Friday, April 15, 2022 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

Matthias Truttman, Ph.D.
Assistant Professor, Department of Molecular & Integrative Physiology
University of Michigan

]]>
Livestream / Virtual Wed, 23 Mar 2022 10:41:54 -0400 2022-04-15T10:00:00-04:00 2022-04-15T11:00:00-04:00 Life Sciences Institute U-M Structural Biology Livestream / Virtual structure
MCDB Seminar> Long-term imaging of cortical and spinal cord pain processing in the awake, behaving mouse (April 15, 2022 12:00pm) https://events.umich.edu/event/90432 90432-21670808@events.umich.edu Event Begins: Friday, April 15, 2022 12:00pm
Location: Biological Sciences Building
Organized By: Department of Molecular, Cellular, and Developmental Biology

Host: Bo Duan

]]>
Workshop / Seminar Mon, 11 Apr 2022 13:01:40 -0400 2022-04-15T12:00:00-04:00 2022-04-15T13:00:00-04:00 Biological Sciences Building Department of Molecular, Cellular, and Developmental Biology Workshop / Seminar Yellow MCDB initials and microscope cartoon on blue background
BIBC Research Seminar (April 15, 2022 4:00pm) https://events.umich.edu/event/93656 93656-21707957@events.umich.edu Event Begins: Friday, April 15, 2022 4:00pm
Location: Off Campus Location
Organized By: BioInnovations in Brain Cancer

The BIBC seminars will showcase the multidisciplinary research of faculty studying brain cancer biology and novel technologies that can be used for brain cancer diagnosis and treatment.

Please join us on Friday, April 15, 4-5pm to hear from Dr. Michelle Kim and Dr. Aki Morikawa on their work in developing advanced imaging for glioblastoma and systemic therapeutic options for CNS metastasis. This meeting will be held over a Zoom Webinar using the link and passcode below.

Zoom link: https://umich.zoom.us/j/94080044960
Passcode: 106863

]]>
Livestream / Virtual Mon, 21 Mar 2022 09:24:01 -0400 2022-04-15T16:00:00-04:00 2022-04-15T17:00:00-04:00 Off Campus Location BioInnovations in Brain Cancer Livestream / Virtual
BioArtography - Call for Images (April 16, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742278@events.umich.edu Event Begins: Saturday, April 16, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-16T00:00:00-04:00 2022-04-16T23:59:00-04:00 BioArtography Other U-M BioArtography
BioArtography - Call for Images (April 17, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742279@events.umich.edu Event Begins: Sunday, April 17, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-17T00:00:00-04:00 2022-04-17T23:59:00-04:00 BioArtography Other U-M BioArtography
BioArtography - Call for Images (April 18, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742280@events.umich.edu Event Begins: Monday, April 18, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-18T00:00:00-04:00 2022-04-18T23:59:00-04:00 BioArtography Other U-M BioArtography
RNA Innovation Seminar: "Signaling Pathway Variation and Evolutionary Hotspots in the Fungi" (April 18, 2022 12:00pm) https://events.umich.edu/event/92834 92834-21697178@events.umich.edu Event Begins: Monday, April 18, 2022 12:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

In-person/Hybrid seminar
Zoom: https://umich.zoom.us/webinar/register/WN_7wk1SlRdQ_e04VnwcjVV7g

Talk title: “Signaling Pathway Variation and Evolutionary Hotspots in the Fungi"

Keywords:
population genomics, statistical genetics, gene networks, microbial pathogenesis

Abstract:
Evolutionarily conserved signal transduction pathways, such as Ras-cAMP-PKA, calcineurin, and TOR signaling, are primary regulators of stress responses and morphogenetic processes across the fungal tree of life. From an evolutionary perspective, these pathways are expected to be under relatively strong stabilizing selection, as loss-of-function mutations (LoF) in these pathways typically lead to reduced growth rates and increased sensitivity to environmental stresses. We have carried out comparative population genomic analyses of signaling pathway LoF alleles for multiple fungal species, and find that several pathways exhibit unusually high frequencies of naturally occurring putative LoF alleles. We discuss the implications of this finding for the evolutionary lability of signaling pathways in the fungi, and combine information on loss-of-function alleles with related evidence from QTL mapping and experimental evolution studies to identify pathways that may act as "evolutionary hotspots" for adaptation to novel environments.

If you are having trouble registering, please contact Martina Jerant at mjerant@umich.edu

]]>
Lecture / Discussion Mon, 18 Apr 2022 10:56:03 -0400 2022-04-18T12:00:00-04:00 2022-04-18T13:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion Paul Magwene, Ph.D., Duke University