Happening @ Michigan https://events.umich.edu/list/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. DCM&B Tools and Technology Seminar (January 20, 2022 12:00pm) https://events.umich.edu/event/89769 89769-21665747@events.umich.edu Event Begins: Thursday, January 20, 2022 12:00pm
Location: Off Campus Location
Organized By: DCMB Tools and Technology Seminar

This presentation will be given remotely, with the livestream available via Zoom.

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Presentation Mon, 17 Jan 2022 10:08:14 -0500 2022-01-20T12:00:00-05:00 2022-01-20T13:00:00-05:00 Off Campus Location DCMB Tools and Technology Seminar Presentation
Organizational Science and Health Care (January 21, 2022 1:30pm) https://events.umich.edu/event/90175 90175-21668509@events.umich.edu Event Begins: Friday, January 21, 2022 1:30pm
Location: Ross School of Business
Organized By: Interdisciplinary Committee on Organizational Studies - ICOS

Research on topics of organizational science in health care settings for a variety of reasons has proliferated in recent years across both organization- and health-focused disciplines. Yet, questions abound about what we as organizational scholars know, what we have learned, and whether the research we are conducting is relevant. The first goal of this session is to take stock of this important domain by drawing together findings from two recent works: a critical history and analysis of the patient safety movement and an analysis of almost 700 articles published over the past decade in leading organizational science (OS) and health care (HC) journals. A second goal is to provide insight into promising avenues that could ultimately advance organizational science and health care with future research that is both rigorous and relevant.

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Lecture / Discussion Tue, 21 Dec 2021 22:41:02 -0500 2022-01-21T13:30:00-05:00 2022-01-21T15:00:00-05:00 Ross School of Business Interdisciplinary Committee on Organizational Studies - ICOS Lecture / Discussion Ross School of Business
Organizational Science and Health Care (January 21, 2022 1:30pm) https://events.umich.edu/event/90175 90175-21668766@events.umich.edu Event Begins: Friday, January 21, 2022 1:30pm
Location: Off Campus Location
Organized By: Interdisciplinary Committee on Organizational Studies - ICOS

Research on topics of organizational science in health care settings for a variety of reasons has proliferated in recent years across both organization- and health-focused disciplines. Yet, questions abound about what we as organizational scholars know, what we have learned, and whether the research we are conducting is relevant. The first goal of this session is to take stock of this important domain by drawing together findings from two recent works: a critical history and analysis of the patient safety movement and an analysis of almost 700 articles published over the past decade in leading organizational science (OS) and health care (HC) journals. A second goal is to provide insight into promising avenues that could ultimately advance organizational science and health care with future research that is both rigorous and relevant.

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Lecture / Discussion Tue, 21 Dec 2021 22:41:02 -0500 2022-01-21T13:30:00-05:00 2022-01-21T15:00:00-05:00 Off Campus Location Interdisciplinary Committee on Organizational Studies - ICOS Lecture / Discussion
Programmable Biomaterials/Regenerative Medicine Grand Challenge (January 24, 2022 1:00pm) https://events.umich.edu/event/88715 88715-21677237@events.umich.edu Event Begins: Monday, January 24, 2022 1:00pm
Location: Off Campus Location
Organized By: Regenerative Medicine Biosciences Initiative

Programmable Biomaterials/Regenerative Medicine Grand Challenge #1

Theme: How to regenerate tissues/organs to optimally integrate with the host

Goal: Bring together clinicians, scientists, and engineers to explore new ideas and catalyze new collaborations to address key barriers to the translation of regenerative medicine technologies

Format: Short talks identifying clinical problems and emerging technologies, followed by breakout sessions to identify opportunities

Breakouts: Based on problems identified, what are transformative things UM can do to solve? We’re looking for big ideas that involve new, heterogeneous groups. Themes/challenges that emerge from breakouts will define an RFA

Outcome: Funding for collaborative proposals that emerge from the grand challenge session w/ criteria that proposals are novel and integrative, satisfying one or more of the following elements:
•High risk, cross-cutting, transformative
•Leverage strengths at UM in new ways
•Pull together new combinations of people
•Tackle new problems or existing problems in new ways
•Topics that will have greatest impact and potential for extramural funding
•We anticipate awarding 3 grants at ~100K each
Please join us for our 2-day VIRTUAL event January 24 and January 25.

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Workshop / Seminar Tue, 18 Jan 2022 19:32:41 -0500 2022-01-24T13:00:00-05:00 2022-01-24T18:30:00-05:00 Off Campus Location Regenerative Medicine Biosciences Initiative Workshop / Seminar Purple Pipette
Programmable Materials/Regenerative Medicine Grand Challenge-Breakout Sessions (January 25, 2022 9:00am) https://events.umich.edu/event/88716 88716-21656961@events.umich.edu Event Begins: Tuesday, January 25, 2022 9:00am
Location: Off Campus Location
Organized By: Regenerative Medicine Biosciences Initiative

Programmable Biomaterials/Regenerative Medicine Grand Challenge Breakout Rooms

Theme: How to regenerate tissues/organs to optimally integrate with the host

Goal: Bring together clinicians, scientists, and engineers to explore new ideas and catalyze new collaborations to address key barriers to the translation of regenerative medicine technologies

Format: Short talks identifying clinical problems and emerging technologies, followed by breakout sessions to identify opportunities

Breakouts: Based on problems identified, what are transformative things UM can do to solve? We’re looking for big ideas that involve new, heterogeneous groups. Themes/challenges that emerge from breakouts will define an RFA

Outcome: Funding for collaborative proposals that emerge from the grand challenge session w/ criteria that proposals are novel and integrative, satisfying one or more of the following elements:
•High risk, cross-cutting, transformative
•Leverage strengths at UM in new ways
•Pull together new combinations of people
•Tackle new problems or existing problems in new ways
•Topics that will have greatest impact and potential for extramural funding
•We anticipate awarding 3 grants at ~100K each
Please join us for our 2-day VIRTUAL event January 24 and January 25.

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Workshop / Seminar Tue, 18 Jan 2022 19:31:38 -0500 2022-01-25T09:00:00-05:00 2022-01-25T12:00:00-05:00 Off Campus Location Regenerative Medicine Biosciences Initiative Workshop / Seminar Regenerative Medicine Grand Challenge
CVFS COVID-19 2021 Pilot (January 26, 2022 2:00pm) https://events.umich.edu/event/85341 85341-21626254@events.umich.edu Event Begins: Wednesday, January 26, 2022 2:00pm
Location: Off Campus Location
Organized By: Institute for Social Research

This webinar series on the Chitwan Valley Family Study (CVFS) is about global and comparative population research. Sessions include measuring mental health, Covid-19, linking data, genetics, & migrant data.

Webinar 9: CVFS COVID-19 2021 Pilot
Wednesday, January 26, 2022
2-3pm EDT
Presenter: Sabrina Hermosilla

This webinar will review the methods and primary findings from the COVID-19 CVFS Pilot Study implemented in the first quarter of 2021. This study explored the physical, social, and economic disruptions caused by COVID-19 prevention measures within households of the CVFS. There will be a Q&A session after the presentation.

The webinar will be hosted using Zoom. Registration is required to attend the webinar. Support provided by NICHD (R25 HD101358).

Registration is required for this event: https://umich.zoom.us/meeting/register/tJYqcuCgpz8jGtNqH0O03W4w1QbQmBQAS1ph

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Presentation Tue, 17 Aug 2021 14:47:13 -0400 2022-01-26T14:00:00-05:00 2022-01-26T15:00:00-05:00 Off Campus Location Institute for Social Research Presentation Nepal mountains
DCM&B Tools and Technology Seminar (January 27, 2022 12:00pm) https://events.umich.edu/event/89771 89771-21665751@events.umich.edu Event Begins: Thursday, January 27, 2022 12:00pm
Location: Off Campus Location
Organized By: DCMB Tools and Technology Seminar

Tool link: https://github.com/statgen/savvy

This presentation will be given remotely, with the livestream available via Zoom.

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Presentation Thu, 20 Jan 2022 15:23:09 -0500 2022-01-27T12:00:00-05:00 2022-01-27T13:00:00-05:00 Off Campus Location DCMB Tools and Technology Seminar Presentation
Elasticity Imaging: From Fibrosis and Tumor Pressure to Mechanotransduction and Visualizing Primary Neuronal Activity (January 27, 2022 3:30pm) https://events.umich.edu/event/91489 91489-21680069@events.umich.edu Event Begins: Thursday, January 27, 2022 3:30pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Abstract:
Only recently have we understood the importance of mechanical forces between cells to generate tissue homeostasis. This translates equally to the organ level with tissue biomechanics an excellent proxy for pathological alterations.

In this lecture we will review the current method of quantifying tissue biomechanics via MRI using mechanical shear waves elicitated at the surface of the patient, new ways to quantify non-invasively tumour pressure via non-linear mechanics, and look into mechanical changes induced by neuronal activities. Finally, we will change our position from being a passive bystander quantifying tissue mechanics to an active player altering cellular fate via shear waves.
Bio:
Professor Ralph Sinkus is a physicist with a background in high energy physics, nuclear physics and MRI. He has dual labs at King’s College London’s School of Biomedical Engineering and Imaging Sciences as well as at INSERM (University Paris Diderot, Sorbonne Paris Cité, Hôpital Bichat/Beaujon, Paris, France). After a PhD in high energy physics (DESY, Deutsches Elektronen Synchrotron, Hamburg, Germany), Professor Sinkus took a position at Philips Medical Systems Research Laboratories (Hamburg, Germany) focusing on magnetic resonance imaging (MRI) and elastography. Moving back to academia, Professor Sinkus worked for the Laboratoire Ondes et Acoustique (ESPCI) in Paris, France as a research director until accepting a chair position at King’s College London. Professor Sinkus is an expert in MRI and MR-elastography, and works with a diverse range of clinicians, biomedical engineers, physists and mathematicians for the translation of these technologies to address clinical diagnostics through imaging.
Organized by:
Dr. Brendon Baker,
Assistant Professor, Biomedical Engineering

Dr. David Nordsletten,
Associate Professor, Department of Biomedical Engineering and Cardiac Surgery

Zoom Link: https://umich.zoom.us/j/96508834308

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Workshop / Seminar Tue, 25 Jan 2022 13:56:46 -0500 2022-01-27T15:30:00-05:00 2022-01-27T16:30:00-05:00 Off Campus Location Biomedical Engineering Workshop / Seminar BME Seminar
The Scars of Life Course Trauma on the Immune System (January 31, 2022 12:00pm) https://events.umich.edu/event/90732 90732-21673478@events.umich.edu Event Begins: Monday, January 31, 2022 12:00pm
Location: Off Campus Location
Organized By: Institute for Social Research

The Scars of Life Course Trauma on the Immune System
by Grace Noppert

Monday, January 31
12-1:10 pm ET via Zoom

Abstract:
We are currently observing an unprecedented rise in childhood trauma from COVID-19—specifically related to the loss and disruption of caregiving. Yet, we know little about the impact or persistence of early life trauma on later life immune function. Using nationally representative data on older adults from the U.S. Health and Retirement Study, we examined the association between experiencing parental death or parental separation before the age of 16 years and four markers of immune function in late life: high sensitive C-reactive Protein (CRP), Interleukin-6 (IL-6), soluble Tumor Necrosis Factor (sTNFR), and immune response to cytomegalovirus (CMV) measured by the level of Immunoglobulin G (IgG). We also examined racial and ethnic differences in these associations. We found that racialized minority individuals were more likely to experience parental death/separation in early life compared to non-Hispanic Whites and had poorer immune function in later life. We also found consistent associations between parental death or separation and poor immune function in later life measured by both CMV and IL-6 across all race/ethnic subgroups. This presentation will discuss the growing body of evidence that early life trauma becomes embedded in the architecture of the immune system with consequences for health throughout the life course.

Bio:
Dr. Noppert's work lies at the intersection of biology, sociology, and epidemiology. Her work seeks to explain how social processes become biologically embedded with implications for health across the life course. She began her work as an infectious disease epidemiologist examining health disparities in tuberculosis (TB) in the U.S. Since then, her work has focused on uncovering the social underpinning of a range of infectious diseases, both established (e.g., TB) and emergent (e.g., SARS-CoV-2). Her current work focuses on sociobiological exposures such as persistent viral infections (e.g., CMV, HSV-1, etc.) and how they intersect with the immune system. Understanding the link between social factors, infections, and immune function may hold clues to explaining and disrupting persistent health inequities across the life course.

Michigan Population Studies Center (PSC) Brown Bag seminars highlight recent research in population studies and serve as a focal point for building our research community.

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Lecture / Discussion Tue, 18 Jan 2022 13:39:42 -0500 2022-01-31T12:00:00-05:00 2022-01-31T13:00:00-05:00 Off Campus Location Institute for Social Research Lecture / Discussion event flyer
DCM&B Tools and Technology Seminar (February 3, 2022 12:00pm) https://events.umich.edu/event/89792 89792-21665801@events.umich.edu Event Begins: Thursday, February 3, 2022 12:00pm
Location: Off Campus Location
Organized By: DCMB Tools and Technology Seminar

The MinION is a recent-to-market handheld nanopore sequencer. It can be used to determine the whole genome of a target virus in a biological sample. Its Read Until feature allows us to skip sequencing a majority of non-target reads (DNA/RNA fragments), which constitutes more than 99% of all reads in a typical sample. However, it does not have any on-board computing, which significantly limits its portability. We analyze the performance of a Read Until metagenomic pipeline for detecting target viruses and identifying strain-specific mutations. We find new sources of performance bottlenecks (basecaller in classification of a read) that are not addressed by past genomics accelerators. We present SquiggleFilter, a novel hardware accelerated dynamic time warping (DTW) based filter that directly analyzes MinION’s raw squiggles and filters everything except target viral reads, thereby avoiding the expensive basecalling step. We show that our 14.3W 13.25mm2 accelerator has 274 × greater throughput and 3481 × lower latency than existing GPU-based solutions while consuming half the power, enabling Read Until for the next generation of nanopore sequencers.

SquiggleFilter: https://github.com/TimD1/SquiggleFilter
Associated Article: https://dl.acm.org/doi/10.1145/3466752.3480117

Speaker Bio: Hari Sadasivan is a PhD candidate in CSE focusing on hardware-software co-design for accelerating healthcare solutions like genome sequencing for microbiome abundance and precision medicine.

This presentation will be given remotely, with the livestream available via Zoom.

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Presentation Thu, 20 Jan 2022 15:24:09 -0500 2022-02-03T12:00:00-05:00 2022-02-03T13:00:00-05:00 Off Campus Location DCMB Tools and Technology Seminar Presentation
Learning Health Systems: A Pathway to Sustainable Health Improvement (February 3, 2022 12:00pm) https://events.umich.edu/event/91725 91725-21682582@events.umich.edu Event Begins: Thursday, February 3, 2022 12:00pm
Location:
Organized By: Office of Research School of Dentistry

Charles Friedman is the Josiah Macy Jr. Professor of Medical Education and Chair of the Department of Learning Health Sciences at the University of Michigan Medical School. In recent years, he has focused his academic interests and activities on the concept of Learning Health Systems, and the socio-technical infrastructure required to sustain them. He is editor-in-chief of the open-access journal Learning Health Systems and co-chair of the movement to Mobilize Computable Biomedical Knowledge.

He was recently awarded an honorary doctorate by the University of Lucerne in Switzerland for his contributions to the science of Learning Health Systems.
Prior to coming to Michigan, Friedman held executive positions at the Office of the National Coordinator for Health IT (ONC) in the U.S. Department of Health and Human Services. Immediately prior to his work in the government, Dr. Friedman was Associate Vice Chancellor for Biomedical Informatics, and Founding Director of the Center for Biomedical Informatics at the University of Pittsburgh.

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Presentation Mon, 31 Jan 2022 11:39:40 -0500 2022-02-03T12:00:00-05:00 2022-02-03T13:00:00-05:00 Office of Research School of Dentistry Presentation Charles P. Friedman, PhD
Targeting and monitoring focused ultrasound in the brain with MRI (February 3, 2022 3:30pm) https://events.umich.edu/event/91561 91561-21680566@events.umich.edu Event Begins: Thursday, February 3, 2022 3:30pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: Biomedical Engineering

Abstract:
Focused ultrasound is a noninvasive therapeutic modality in which ultrasound waves are focused to a point in the body to manipulate a target without affecting intervening tissue. Some of the most promising applications for focused ultrasound are in the brain, where it is FDA-approved for thermal ablation in movement disorders, and is also being explored for blood brain barrier opening and neuromodulation. MRI plays a critical role in targeting and monitoring the effects of transcranial focused ultrasound through its ability to image not only fine brain structures but also temperature and tissue displacement. In this talk I will present our efforts to overcome the myriad technical challenges associated with MRI guidance of transcranial focused ultrasound, including achieving volumetric coverage in brain thermometry, alleviating signal voids and artifacts caused by the presence of the transducer and its coupling media, and rapidly imaging tissue displacement to localize the focus and compensate acoustic aberrations caused by the skull. 

Bio:
Will Grissom is an Associate Professor of Biomedical Engineering at Vanderbilt University. He received his PhD from the University of Michigan in 2008, completed a postdoctoral fellowship at Stanford University in 2009, and worked as a Research Engineer at GE Global Research in Munich Germany until 2011. He then joined the Department of Biomedical Engineering and the Institute of Imaging Science at Vanderbilt University where he works on RF pulse design, image reconstruction, and RF coils for MRI from 47 mT to 7 T, and develops interventional MRI methods for guiding focused ultrasound and laser ablation and neuromodulation.

Organized by:
Dr. Brendon Baker,
Assistant Professor, Biomedical Engineering

Dr. David Nordsletten,
Associate Professor, Department of Biomedical Engineering and Cardiac Surgery

Zoom Link: https://umich.zoom.us/j/96508834308
Location: 1131 LBME, 1101 Beal Ave., Ann Arbor, MI 48109-2110

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Workshop / Seminar Wed, 26 Jan 2022 15:42:01 -0500 2022-02-03T15:30:00-05:00 2022-02-03T16:30:00-05:00 Lurie Biomedical Engineering (formerly ATL) Biomedical Engineering Workshop / Seminar BME Seminar
Jeff Galvin (American Gene Technologies, CEO) - Gene and Cell Development, Genetically Modified Organisms, Software, Business (February 7, 2022 6:00pm) https://events.umich.edu/event/88951 88951-21659250@events.umich.edu Event Begins: Monday, February 7, 2022 6:00pm
Location: Off Campus Location
Organized By: Bio-Tech, Entrepreneurship, and Coding Organization

On Monday, February 07, 2022 @ 6:00PM-7:00PM ET, come virtually listen to Jeff Galvin (Harvard '81 Economics; CEO of American Gene Technologies and VP/CEO/Director of various other private and public technology companies) discuss gene therapy vs. cell therapy, recombinant DNA, how cells are grown and manipulated for commercial products, genetically modified organisms, and international business, all with connections to food, beverage, agriculture, nutrition, healthcare, and general biotechnology.

American Gene Technologies (AGT) is a private company developing and commercializing genetic medicines targeting major diseases, including HIV/AIDS, Phenylketonuria (PKU) and Hepatocellular carcinoma (liver cancer, or HCC). Its drug candidates have achieved initial proof of concept in preclinical studies, are in clinical trials, and have potential to deliver cost-effective therapies that are better targeted and more potent with fewer side effects. AGT’s drugs will treat symptomatic diseases, but are intended to provide durable cures that extend the length and improve the quality of patients’ lives using its unique gene-delivery platform.

This event is co-hosted by two student organizations: biology-focused Michigan Synthetic Biology Team ("MSBT"), business-focused Bio-Tech, Entrepreneurship, and Coding Organization ("BECO"), and engineering-focused Food Industry Student Association ("FISA"). Please navigate to MSBT's, BECO's, and FISA's respective homepages linked on this post to learn more and join their email lists.

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Workshop / Seminar Thu, 03 Feb 2022 07:20:59 -0500 2022-02-07T18:00:00-05:00 2022-02-07T19:00:00-05:00 Off Campus Location Bio-Tech, Entrepreneurship, and Coding Organization Workshop / Seminar Cells
What has the Pandemic Taught Us About the American System of Health Insurance? (February 8, 2022 10:00am) https://events.umich.edu/event/91134 91134-21676769@events.umich.edu Event Begins: Tuesday, February 8, 2022 10:00am
Location: Off Campus Location
Organized By: Osher Lifelong Learning Institute (50+)

Health insurance in the U.S. comes from many different public and private sources. This talk will consider how the coronavirus has illuminated the weaknesses (and one surprising strength) of our decentralized approach to courage.

Dr. Helen Levy is a Research Professor in the Department of Health Management and Policy; she is also a Research Professor at the Institute for Social Research and the Ford School of Public Policy. She is a Research Associate at the National Bureau of Economic Research. Before coming to the University of Michigan she was an Assistant Professor at the Harris Graduate School of Public Policy Studies at the University of Chicago and a Robert Wood Johnson Foundation Scholar in Health Policy Research at the University of California at Berkeley. In 2010 - 2011, Dr. Levy served as a Senior Economist to the President’s Council of Economic Advisers in Washington, DC.

Dr. Levy’s research interests include the causes and consequences of lacking health insurance, evaluation of public health insurance programs, and the role of health literacy in explaining disparities in health outcomes. She is a co-Investigator on the Health and Retirement Study, a long-running longitudinal study of health and economic dynamics at older ages. She is currently the recipient of a Career Development Award from the National Institute on Aging to study health literacy and health disparities among the elderly.

This is the first of five lectures to be presented once each month from February through June of 2022. A new series will start in September 2022.The next lecture in the current series will take place March 8, 2022.The title is: The Dagger in the Heart of Christianity. Learn from well-known experts about an array of interesting subjects, with an interactive Q&A period following each lecture.

Preregistration is required via the OLLI website or phone. A link to access the lecture will be e-mailed to you approximately one week prior to the first session.

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Lecture / Discussion Mon, 17 Jan 2022 15:54:02 -0500 2022-02-08T10:00:00-05:00 2022-02-08T11:30:00-05:00 Off Campus Location Osher Lifelong Learning Institute (50+) Lecture / Discussion OLLI Image
Long-term Air Pollution and Incident Dementia in U.S. (February 8, 2022 12:00pm) https://events.umich.edu/event/91240 91240-21677512@events.umich.edu Event Begins: Tuesday, February 8, 2022 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

REGISTRATION REQUIRED
https://umich.zoom.us/webinar/register/WN_d_LFab2xTmmTjHuJsfZLmg

Liuhua Shi, ScD, is Assistant Professor of Environmental Health in the Rollins School of Public Health at Emory University.

Dr. Shi's research focuses on employing massive datasets, including satellite-retrieved high resolution exposures and health data, to investigate how climate change and air pollution influence seniors' health.

More specifically, her research is focused on:
1. application of remote sensing in environmental exposure modeling (e.g., predicting high-resolution PM2.5, ozone, NO2, and temperature);
2. estimating the health consequences of exposure to air pollution and climate change;
3. estimating the link between climate change and air quality, and the mediated health impacts;
4. estimating the joint and independent health effects of air pollutant mixtures;
5. statistical modeling, e.g., causal modeling and big data approach.

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Lecture / Discussion Wed, 19 Jan 2022 13:12:34 -0500 2022-02-08T12:00:00-05:00 2022-02-08T12:50:00-05:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Air pollution and dementia
Food Literacy for All:“Beginning Farmers, Environment, and Feeding Community” (February 8, 2022 6:30pm) https://events.umich.edu/event/90247 90247-21668925@events.umich.edu Event Begins: Tuesday, February 8, 2022 6:30pm
Location: Off Campus Location
Organized By: UM Sustainable Food Systems Initiative

Launched in 2017, Food Literacy for All is a community-academic partnership course based at the University of Michigan. Structured as an evening lecture series, Food Literacy for All features different guest speakers each week to address challenges and opportunities of diverse food systems.

The course is free and open to the public. The 2022 course is virtual on Tuesday evenings at 6:30pm EST.

Food Literacy 2022 Registration: https://umich.zoom.us/webinar/register/WN_0TGY1FaMRMSW2VzuP2pPDQ

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Workshop / Seminar Fri, 21 Jan 2022 12:47:08 -0500 2022-02-08T18:30:00-05:00 2022-02-08T20:00:00-05:00 Off Campus Location UM Sustainable Food Systems Initiative Workshop / Seminar Special thanks to our co-sponsors!
Craniofacial Regeneration, Stem Cells, and Clinical Cell Therapy...Where are we now? (February 10, 2022 12:00pm) https://events.umich.edu/event/91853 91853-21683555@events.umich.edu Event Begins: Thursday, February 10, 2022 12:00pm
Location:
Organized By: Office of Research School of Dentistry

Major M. Ash Collegiate Professor of Periodontics
Department of Periodontics and Oral Medicine
University of Michigan

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Presentation Wed, 02 Feb 2022 08:43:33 -0500 2022-02-10T12:00:00-05:00 2022-02-10T13:00:00-05:00 Office of Research School of Dentistry Presentation Darnell Kaigler, Jr., D.D.S, M.S., Ph.D.
Physiologic mechanics drive contractile development in stem cell derived cardiac muscle to model genetic heart disease (February 10, 2022 3:30pm) https://events.umich.edu/event/92035 92035-21686280@events.umich.edu Event Begins: Thursday, February 10, 2022 3:30pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Physiologic mechanics drive contractile development in stem cell derived cardiac muscle to model genetic heart disease

Abstract:
Disorganized mechanics and immaturity of stem cell derived cardiomyocytes have been hurdles to reproducible applications for regenerative medicine or disease modeling. We developed a platform of micron-scale cardiac muscle bundles to control biomechanics in arrays of thousands of purified, independently contracting cardiac muscle strips on two-dimensional elastomer substrates. By defining geometry and workload in this reductionist platform, we show that myofibrillar alignment and auxotonic contractions at physiologic workload drive maturation of contractile function, calcium handling, and electrophysiology. Using transcriptomics, reporter hPSC-CMs, and quantitative immunofluorescence, these cardiac muscle bundles can be used to parse orthogonal cues in early development, including contractile force, calcium load, and metabolic signals. Additionally, the resultant organized biomechanics facilitates automated extraction of contractile kinetics from brightfield microscopy imaging, increasing the accessibility, reproducibility, and throughput of pharmacologic testing. Our lab is working toward applications of this system to understand human cardiomyopathies caused by variants that affect cardiomyocyte structure and function.

Bio:
Dr. Helms is a physician-scientist in the Division of Cardiovascular Medicine at the University of Michigan. He co-directs the Inherited Cardiomyopathy and Arrhythmia Clinic. His lab studies genetic cardiomyopathy using stem cell derived cardiomyocyte and mouse models. 

Zoom Link: https://umich.zoom.us/j/96508834308

Organized by:
Dr. Brendon Baker,
Assistant Professor, Biomedical Engineering

Dr. David Nordsletten,
Associate Professor, Department of Biomedical Engineering and Cardiac Surgery

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Workshop / Seminar Wed, 09 Feb 2022 10:16:37 -0500 2022-02-10T15:30:00-05:00 2022-02-10T16:30:00-05:00 Off Campus Location Biomedical Engineering Workshop / Seminar BME Seminar
COVID-19 and Re-Enchanting Medicine (February 11, 2022 12:00pm) https://events.umich.edu/event/91006 91006-21675422@events.umich.edu Event Begins: Friday, February 11, 2022 12:00pm
Location: Off Campus Location
Organized By: The University of Michigan Medical School Program on Health, Spirituality and Religion

The Woll Family Speaker Series on Health, Spirituality and Religion presents

Lydia Dugdale, MD, MAR (Ethics), Dorothy L. and Daniel H. Silberberg Associate Professor of Medicine, Director, Center for Clinical Medical Ethics, Associate Director of Clinical Ethics, New York Presbyterian Hospital, Columbia Vagelos College of Physician and Surgeons

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Workshop / Seminar Fri, 14 Jan 2022 07:23:59 -0500 2022-02-11T12:00:00-05:00 2022-02-11T13:00:00-05:00 Off Campus Location The University of Michigan Medical School Program on Health, Spirituality and Religion Workshop / Seminar Seminar announcement
Medical School Application workshop (February 14, 2022 5:00pm) https://events.umich.edu/event/90755 90755-21673507@events.umich.edu Event Begins: Monday, February 14, 2022 5:00pm
Location: Off Campus Location
Organized By: LSA Honors Program

Are you planning on applying to medical school this summer and want help in this process? If so, we invite you to attend this Honors Program workshop led by Stephanie Chervin, LSA Honors Program Pre-Med Advisor, to help you:

• Understand the timeline of the process from application to interview

• Choose target medical programs

• Get acquainted with the application service AMCAS

Bring your questions! This session is for current LSA Honors Program students only.

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Workshop / Seminar Mon, 10 Jan 2022 13:17:09 -0500 2022-02-14T17:00:00-05:00 2022-02-14T18:15:00-05:00 Off Campus Location LSA Honors Program Workshop / Seminar Stethoscope and Laptop Computer. Laptop computers and other kinds of mobile devices and communications technologies are of increasing importance in the delivery of health care. Photographer Daniel Sone
CANCELLED - Laura Lindberg - Quality of Abortion Reporting in the US and Pathways to Improvement (February 16, 2022 12:00pm) https://events.umich.edu/event/91431 91431-21679571@events.umich.edu Event Begins: Wednesday, February 16, 2022 12:00pm
Location: Off Campus Location
Organized By: Michigan Program in Survey and Data Science

Laura Lindberg
Principal Research Scientist, Guttmacher Institute

Dr. Laura Lindberg is a Principal Research Scientist at the Guttmacher Institute, where she has worked for nearly two decades. As a social demographer, Dr. Lindberg focuses on measuring the trends, determinants and consequences of sexual and reproductive health in the U.S. population and working to improve the quality of survey data on sexual and reproductive behaviors. She currently has two NICHD grants on measurement of core demographic constructs, abortion and contraceptive failure rates. Over the course of her career, she has conducted policy-related research on adolescent sexual behaviors, sex education, adolescent preventive services, unintended pregnancy and contraceptive use. Dr. Lindberg received her undergraduate degree from Princeton University; she earned her MA and PhD in sociology at the University of Michigan, where her favorite class was on survey research methods with Bob Groves.

Quality of Abortion Reporting in the US and Pathways to Improvement

Despite the fact that an estimated one in five pregnancies in the United States end in induced abortion, abortion remains a highly sensitive, stigmatized and thus difficult-to-measure behavior. I will present on a body of recent research designed to help to develop new techniques and improve existing methodologies for measuring abortion reporting. First, I share a series of quantitative analyses to identify the scope and correlates of abortion underreporting for three of the most commonly used national fertility surveys in the United States: the National Survey of Family Growth, the National Longitudinal Survey of Youth 1997, and the National Longitudinal Study of Adolescent to Adult Health. These analyses informed the development of new question designs were explored in cognitive interviews and experimentally tested and evaluated in a national survey. Abortion underreporting in population surveys has far-reaching implications for research in sexual and reproductive health and maternal and child health.

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Lecture / Discussion Mon, 14 Feb 2022 09:50:07 -0500 2022-02-16T12:00:00-05:00 2022-02-16T13:00:00-05:00 Off Campus Location Michigan Program in Survey and Data Science Lecture / Discussion February 16th Seminar Cancelled
Identifying & Managing Burnout (February 16, 2022 6:00pm) https://events.umich.edu/event/87834 87834-21647058@events.umich.edu Event Begins: Wednesday, February 16, 2022 6:00pm
Location: Off Campus Location
Organized By: Michigan Medicine Wellness Office

Graduate school is constant, stressful, and consumes much of our daily energy. Thankfully there is an endpoint! During graduate school, it's important to recognize and manage signs of burnout in order to get to the finish line while maintaining our mental, physical and emotional health. Join this session to learn more about recognizing and managing burnout, well-being resources and communities, and strategies for managing stress. All of the tools talked about in this session are great for getting through the grind of graduate school and beyond.

Please register to receive zoom link: https://sessions.studentlife.umich.edu/track/event/session/45697

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Well-being Mon, 04 Oct 2021 11:44:08 -0400 2022-02-16T18:00:00-05:00 2022-02-16T19:00:00-05:00 Off Campus Location Michigan Medicine Wellness Office Well-being Wellness Office Logo
DCM&B Tools and Technology Seminar (February 17, 2022 12:00pm) https://events.umich.edu/event/89794 89794-21665803@events.umich.edu Event Begins: Thursday, February 17, 2022 12:00pm
Location: Off Campus Location
Organized By: DCMB Tools and Technology Seminar

I will describe a tool to learn representations of brain activity observed with functional magnetic resonance imaging. I will show how the tool works and how it can be extended. I will use some examples to demonstrate how to decode brain activity, connect brain to behavior, and use brain scans to identify individuals.

Tool Link: https://github.com/libilab/rsfMRI-VAE

This presentation will be remote only via Zoom

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Presentation Wed, 16 Feb 2022 13:03:02 -0500 2022-02-17T12:00:00-05:00 2022-02-17T13:00:00-05:00 Off Campus Location DCMB Tools and Technology Seminar Presentation
Oral Health for All: Opportunities for Improvement and Understanding (February 17, 2022 1:00pm) https://events.umich.edu/event/91753 91753-21683050@events.umich.edu Event Begins: Thursday, February 17, 2022 1:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

Dr. Jennifer Webster-Cyriaque is the deputy director of National Institute of Dental and Craniofacial Research, National Institutes of Health. An accomplished clinician, researcher, and leader, Dr. Webster-Cyriaque had previously served as a faculty member at the University of North Carolina (UNC) schools of dentistry and medicine for more than two decades.

As a tenured full professor at UNC, Dr. Webster-Cyriaque also served as the attending on clinical service at the UNC Hospital’s dental clinic. While there, she led research into a potential etiologic agent for salivary gland disease in patients living with HIV, assessed the oral microbiome and its implications for cancer-causing viruses, and studied the impact of the oral microbiome and oral health on HIV outcomes.

In addition to her research, Dr. Webster-Cyriaque has held leadership roles as the chair/vice chair of the Oral HIV/AIDS Research Alliance, as research director at the National Dental Association Foundation, as director of postdoctoral CTSA training, along with multiple roles within the American Association for Dental, Oral, and Craniofacial Research and the International Association for Dental Research. Since 2004, she has led the UNC Malawi project and provided assistance in founding Malawi’s first dental school in 2019. Dr. Webster-Cyriaque earned her PhD in microbiology/immunology from the University of North Carolina-Chapel Hill in 1998, her DDS from SUNY Buffalo in 1992, and her BA in biology and interdisciplinary social science from SUNY Buffalo in 1988.

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Presentation Tue, 01 Feb 2022 08:51:49 -0500 2022-02-17T13:00:00-05:00 2022-02-17T14:00:00-05:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Presentation Jennifer Webster-Cyriaque, DDS, PhD
Machine Learning in Drug Development (February 17, 2022 3:30pm) https://events.umich.edu/event/92334 92334-21690196@events.umich.edu Event Begins: Thursday, February 17, 2022 3:30pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Abstract:
An undesirable side effect of drugs are cardiac arrhythmias, in particular a condition called torsades de pointes. Current paradigms for drug safety evaluation are costly, lengthy, and conservative, and impede efficient drug development. Here we combine multiscale experiment and simulation, high-performance computing, and machine learning to create an easy-to-use risk assessment diagram to quickly and reliable stratify the pro-arrhythmic potential of new and existing drugs. We capitalize on recent developments in machine learning and integrate information across ten orders of magnitude in space and time to provide a holistic picture of the effects of drugs, either individually or in combination with other drugs. We show, both experimentally and computationally, that drug-induced arrhythmias are dominated by the interplay of two currents with opposing effects: the rapid delayed rectifier potassium current and the L-type calcium current. Using Gaussian process classification, we create a classifier that stratifies safe and arrhythmic domains for any combinations of these two currents. We demonstrate that our classifier correctly identifies the risk categories of 23 common drugs, exclusively on the basis of their concentrations at 50% current block. Our study shapes the way towards establishing science-based criteria to accelerate drug development, design safer drugs, and reduce heart rhythm disorders.
Bio:
Ellen Kuhl is the Walter B. Reinhold Professor in the School of Engineering and Robert Bosch Chair of Mechanical Engineering at Stanford University. She received her PhD from the University of Stuttgart in 2000 and her Habilitation from the University of Kaiserslautern in 2004. Her area of expertise is Living Matter Physics, the design of theoretical and computational models to simulate and predict the behavior of living systems. Ellen has published more than 200 peer-reviewed journal articles, edited two books, and published a textbook on COVID-19. She is a founding member of the Living Heart Project, a translational research initiative to revolutionize cardiovascular science through realistic simulation with 400 participants from research, industry, and medicine from 24 countries. Ellen is the current Chair of the US National Committee on Biomechanics and a Member-Elect of the World Council of Biomechanics. She is a Fellow of the American Society of Mechanical Engineers and of the American Institute for Mechanical and Biological Engineering. She received the National Science Foundation Career Award in 2010, was selected as Midwest Mechanics Seminar Speaker in 2014, and received the Humboldt Research Award in 2016 and the ASME Ted Belytschko Applied Mechanics Award in 2021. Ellen is an All American triathlete, a multiple Boston, Chicago, and New York marathon runner, and a Kona Ironman World Championship finisher.

Zoom Link: https://umich.zoom.us/j/96508834308

Organized by:
Dr. Brendon Baker,
Assistant Professor, Biomedical Engineering

Dr. David Nordsletten,
Associate Professor, Department of Biomedical Engineering and Cardiac Surgery

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Workshop / Seminar Mon, 14 Feb 2022 10:57:37 -0500 2022-02-17T15:30:00-05:00 2022-02-17T16:30:00-05:00 Off Campus Location Biomedical Engineering Workshop / Seminar BME Seminar
Medical School Application Workshop (February 17, 2022 4:00pm) https://events.umich.edu/event/90756 90756-21673508@events.umich.edu Event Begins: Thursday, February 17, 2022 4:00pm
Location: Off Campus Location
Organized By: LSA Honors Program

Are you planning on applying to medical school this summer and want help in this process? If so, we invite you to attend this Honors Program workshop led by Stephanie Chervin, LSA Honors Program Pre-Med Advisor, to help you:

• Understand the timeline of the process from application to interview

• Choose target medical programs

• Get acquainted with the application service AMCAS

Bring your questions! This session is for current LSA Honors Program students only.

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Workshop / Seminar Mon, 10 Jan 2022 13:19:11 -0500 2022-02-17T16:00:00-05:00 2022-02-17T17:15:00-05:00 Off Campus Location LSA Honors Program Workshop / Seminar Stethoscope and Laptop Computer. Laptop computers and other kinds of mobile devices and communications technologies are of increasing importance in the delivery of health care. Photographer Daniel Sone
TEDxUofM 2022 Conference: SHATTERPROOF (February 18, 2022 6:00pm) https://events.umich.edu/event/90984 90984-21675132@events.umich.edu Event Begins: Friday, February 18, 2022 6:00pm
Location: Power Center for the Performing Arts
Organized By: TEDxUofM

TEDxUofM is a university-wide initiative to galvanize the community for an event like no other; filled with inspiration, discovery, and excitement. Borrowing the template from the world-renowned TED conference, TEDxUofM aims to bring a TED-like experience to the University of Michigan. Our vision is to showcase the most fascinating thinkers and doers, the “leaders and best” in Michigan terms, for a stimulating day of presentations, discussions, entertainment, and art that will spark new ideas and opportunities across all disciplines. Our conference will feature 8 speakers, 3 performing groups, and interactive labs/activities for attendees!

Our theme for this year’s conference is SHATTERPROOF. Through a time of fragmentation and dissonance, individuals and communities have showcased an incredible ability to withstand adversity. Resilience is found in all of us despite the size of the challenge. We use our voices to empower each other. We use ideas to drive us forward. We refuse to crack under pressure. We are shatterproof. As we set the stage with this spirit, our goal is for attendees to discover what being shatterproof means to them.

Visit www.tedxuofm.com to get tickets to our Conference!

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Conference / Symposium Thu, 13 Jan 2022 17:56:24 -0500 2022-02-18T18:00:00-05:00 2022-02-18T21:30:00-05:00 Power Center for the Performing Arts TEDxUofM Conference / Symposium TEDxUofM Conference Flyer
We Can Be Heroes Film Screening Event (February 22, 2022 5:30pm) https://events.umich.edu/event/90983 90983-21675131@events.umich.edu Event Begins: Tuesday, February 22, 2022 5:30pm
Location: Off Campus Location
Organized By: UM Addiction Center

On February 22, 2022, the U-M Addiction Center, Washtenaw Families Against Narcotics, and Under the Hood Productions invite you to bring a one-of-a-kind free event to the Michigan Theater on the evening of February 22, 2022, starting at 5:30 p.m. This event will include a:

• Documentary film screening of We Can Be Heroes, from acclaimed director Mike Ramsdell, Under the Hood Productions.The film follows Taylor “Machine Gun” Duerr as he fights his way to a national boxing title inside the ring, while fighting the demons of addiction out of the ring;

• Panel discussion on addiction stigma moderated by the Director of the U-M Addiction Center, Dr. Frederic C. Blow. Panelists include Taylor Duerr, Mike Ramsdell, treatment professionals, and community and national leaders;

• Curated art show featuring local and regional artists who have been affected by substance use disorders, reflecting their experience and their hope; and

• Free print copy of I’m Still a Person: The Stigma of Substance Use & Power of Respect, a workbook designed to help people take thoughtful action to address the stigma of addiction within themselves, their families, and their communities.

Learn more and get your free tickets! http://www.uthproductions.com/wecanbeheroes

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Film Screening Thu, 13 Jan 2022 16:44:54 -0500 2022-02-22T17:30:00-05:00 2022-02-22T21:00:00-05:00 Off Campus Location UM Addiction Center Film Screening We Can Be Heroes Event
Weekly Seminar for DCMB / CCMB (February 23, 2022 4:00pm) https://events.umich.edu/event/92060 92060-21686457@events.umich.edu Event Begins: Wednesday, February 23, 2022 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

In the Peixoto lab we use genomic approaches to understand gene expression and its epigenetic regulation in response to learning and sleep deprivation, and its alteration in autism spectrum disorders. This requires combining behavioral paradigms in mice, molecular biology and the analysis of high-throughput data in the brain in vivo. It also requires using the right data analysis tools to be able to capture the effect of learning or sleep in the context of an ever-active brain. In this talk we will discuss the effects of learning on chromatin accessibility and the effects of sleep loss in gene expression, with an emphasis on how data analysis influences our ability to detect novel and reproducible biology.

Short bio:

Lucia Peixoto received her bachelor’s degree in Biochemistry from the Universidad de la Republica in her native Uruguay in 2002. She subsequently earned her Ph.D. at The University of Pennsylvania under the mentorship of Dr. David S. Roos, using genomic and computational biology approaches to understand host-pathogen interactions. She completed her postdoctoral training in Neuroscience with Dr. Ted Abel at The University of Pennsylvania in 2015. During her fellowship, she was also a trainee at the Training Program in Neurodevelopmental disabilities at the Children’s Hospital of Philadelphia. As a trainee at CHOP, she completed a clinical internship at the Center for Autism Research under the supervision of Dr. Robert Schultz. She became an Assistant Professor at Washington State University in 2015 and has since been recognized with a K01 Early Career Faculty award from NIH/NINDS and a pilot award from the Simons Foundation Autism Research Initiative. She is also a member of the board of directors of the International Society of computational biology (ISCB) and cochair the Equity, Diversity and Inclusion committee of ISCB. Her lab uses behavior, electrophysiology, molecular biology and genomic approaches to understand how sleep and learning modulate transcription and how this may be altered in Autism Spectrum Disorders.

Zoom livestream link: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Workshop / Seminar Mon, 07 Feb 2022 14:54:44 -0500 2022-02-23T16:00:00-05:00 2022-02-23T17:00:00-05:00 Off Campus Location DCMB Seminar Series Workshop / Seminar
DCM&B Tools and Technology Seminar (February 24, 2022 12:00pm) https://events.umich.edu/event/89807 89807-21665816@events.umich.edu Event Begins: Thursday, February 24, 2022 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

Networks are a valuable tool for quantifying a variety of biological relationships, from gene co-expression to cellular proximity. Comparison of these networks can thus shed light on how biological systems vary in different settings, such as across treatment groups or disease states. In this presentation, I present a collection of tools for quantifying and visualizing differences across a set of networks.

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

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Presentation Mon, 06 Dec 2021 18:33:03 -0500 2022-02-24T12:00:00-05:00 2022-02-24T13:00:00-05:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
LHS Collaboratory (February 24, 2022 12:00pm) https://events.umich.edu/event/90079 90079-21667713@events.umich.edu Event Begins: Thursday, February 24, 2022 12:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

The session will describe the landscape history, current status, and future of federated health data networks that are used to support a Learning Health System. Dr. Brown will describe the creation, infrastructure, operation, and uses of several networks from the perspective of a network coordinating center. Dr. Harris will describe insights from participating in multiple networks as a network partner, including infrastructure, governance, and operational lessons learned.

Presenters:
Jeffrey Brown, PhD
Dr. Brown is the inventor of PopMedNet, an open-source software platform that facilitates creation and operation of distributed health data networks.

Marcelline Harris, Ph.D., RN, FACMI
Associate Professor Emerita
Department of Systems, Populations and Leadership
University of Michigan School of Nursing

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Lecture / Discussion Sat, 29 Jan 2022 11:26:41 -0500 2022-02-24T12:00:00-05:00 2022-02-24T13:30:00-05:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion Collaboratory logo
From R&D to the Patient: (February 25, 2022 10:30am) https://events.umich.edu/event/91861 91861-21683567@events.umich.edu Event Begins: Friday, February 25, 2022 10:30am
Location: Off Campus Location
Organized By: William Davidson Institute

Moving health products from the research and development stage to the clinic is a long and costly process that involves many actors, particularly in low- and middle-income countries (LMICs). In these markets, global organizations such as the Bill & Melinda Gates Foundation, the Global Fund to Fight AIDS, TB and Malaria, and Gavi play a significant role in moving health products through the process. These organizations influence market behavior at the research and development, manufacturing, procurement and delivery stages with the hopes of increasing access to life saving health products to patients in LMICs. Their efforts have been effective. For example, over the last 20 years the number of deaths caused by AIDS, tuberculosis and malaria has been reduced by 46% in countries where Global Fund works. Gavi has helped immunize 760 million children in the last 21 years, preventing over 13 million deaths worldwide. These are significant achievements, but are there opportunities to better engage some of the other actors in this space, particularly those from the private sector? We will explore this idea through discussion with the panelists representing the Gates Foundation, the Global Fund and representing the Gates Foundation, the RBM Partnership to End Malaria, and The Global Fund to Fight AIDS, TB & Malaria.

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Livestream / Virtual Wed, 02 Feb 2022 11:42:32 -0500 2022-02-25T10:30:00-05:00 2022-02-25T12:00:00-05:00 Off Campus Location William Davidson Institute Livestream / Virtual From R&D to the Patient: Changing the Role of Business in Global Health
DCM&B Tools and Technology Seminar (March 3, 2022 12:00pm) https://events.umich.edu/event/92260 92260-21688747@events.umich.edu Event Begins: Thursday, March 3, 2022 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

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Presentation Fri, 11 Feb 2022 15:02:48 -0500 2022-03-03T12:00:00-05:00 2022-03-03T13:00:00-05:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
EMERSE Meeting Series (March 3, 2022 2:00pm) https://events.umich.edu/event/91855 91855-21683557@events.umich.edu Event Begins: Thursday, March 3, 2022 2:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Unstructured clinical data, such as clinical notes and reports, along with the computational infrastructure and tools, have seen an increasing demand from the research community in the last years, mostly fueled by recent advances in statistical and machine-learning approaches to data insight. We are meeting this demand with the Information Commons – a research data platform that hosts and provides direct access to de-identified data, advanced analytics tools, and computational environments for our research community. 

While we are realizing access to de-identified electronic health records, images, omics and biobank data, this session highlights the progress made to provide more than 110 million de-identified notes to the research community. We developed and operationalized a fully automatic de-identification algorithm and implemented EMERSE, a user-friendly tool for non-programmatic access and sophisticated textual searches on the de-identified clinical notes.   

As of December 2021 Our de-identification algorithm and our clinical notes are certified de-identified and are currently available for the UCSF researchers with IRD. The presentation covers the entire pipeline from data extraction to publication and data access focusing on the secured computational infrastructure. Furthermore, we discuss the rigorous evaluation techniques to ensure the quality of the deidentification process and the resulting data according to HIPAA and UCSF Security and Privacy protection requirements. Lastly, we showcase highlights from our research collaborations enabled by this new resource of machine-redacted, unstructured clinical notes linked with de-identified structured EHR data using EMERSE and their impact on the research community.

Speakers:
Eric Meeks
Chief Technology Officer, CTSI @University of California, San Francisco

Lakshmi Radhakrishnan
Data Scientist @University of California, San Francisco

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Lecture / Discussion Wed, 02 Feb 2022 09:28:30 -0500 2022-03-03T14:00:00-05:00 2022-03-03T15:00:00-05:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion EMERSE logo
Mind Matters: Navigating Mental Health Treatment (March 3, 2022 7:00pm) https://events.umich.edu/event/91354 91354-21678346@events.umich.edu Event Begins: Thursday, March 3, 2022 7:00pm
Location: Off Campus Location
Organized By: Department of Psychiatry

This is a free webinar for individuals who are looking for help for themselves or a loved one. It will feature a panel of experts as well as individuals who have been through the system who will share their stories.1.0 Continuing Education Credit for Social Workers is available.

The panelists will cover:

-Being diagnosed
-Treatment models
-Financial resources
-How to advocate for yourself or a loved one
-Resources for caregivers


This event is joint collaboration between the Michigan Medicine Department of Psychiatry, Kadima and JVS Human Services.

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Well-being Mon, 24 Jan 2022 09:48:35 -0500 2022-03-03T19:00:00-05:00 2022-03-03T20:30:00-05:00 Off Campus Location Department of Psychiatry Well-being Registration Required
Med Madness with Wayne State School of Medicine! (March 8, 2022 7:00pm) https://events.umich.edu/event/93043 93043-21699563@events.umich.edu Event Begins: Tuesday, March 8, 2022 7:00pm
Location: Palmer Commons
Organized By: MAPS (Multicultural Association for Pre-health Students)

Come join us to hear from representative Dawn Yargeau and Vice Dean for Diversity and Inclusion Dr. Donovan Roy from the Wayne State School of Medicine! Learn about all that the Wayne State School of Medicine has to offer and get your questions answered!

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Workshop / Seminar Sat, 05 Mar 2022 12:11:47 -0500 2022-03-08T19:00:00-05:00 2022-03-08T20:00:00-05:00 Palmer Commons MAPS (Multicultural Association for Pre-health Students) Workshop / Seminar event flyer
Potential and Pitfalls of Polygenic Scores For Social Demographic Research (March 9, 2022 2:00pm) https://events.umich.edu/event/85344 85344-21626257@events.umich.edu Event Begins: Wednesday, March 9, 2022 2:00pm
Location: Off Campus Location
Organized By: Institute for Social Research

This webinar series on the Chitwan Valley Family Study (CVFS) is about global and comparative population research. Sessions include measuring mental health, Covid-19, linking data, genetics, & migrant data.

Webinar 12: Potential and Pitfalls of Polygenic Scores For Social Demographic Research
Wednesday, March 9, 2022
2-3pm EDT
Presenter: Colter Mitchell

This webinar will provide an overview of the methodology around the construction of polygenic scores and their applications in demographic research. There will be a Q&A session after the presentation.

The webinar will be hosted using Zoom. Registration is required to attend the webinar. Support provided by NICHD (R25 HD101358).

Registration is required for this event: https://umich.zoom.us/meeting/register/tJwqde2tpzovGt21ffMiK7ndNIVGOovGaCqi

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Presentation Tue, 17 Aug 2021 15:01:18 -0400 2022-03-09T14:00:00-05:00 2022-03-09T15:00:00-05:00 Off Campus Location Institute for Social Research Presentation Nepal mountains
BioArtography - Call for Images (March 10, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701901@events.umich.edu Event Begins: Thursday, March 10, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-10T00:00:00-05:00 2022-03-10T23:59:00-05:00 BioArtography Other U-M BioArtography
Virtual Physician Shadow: Live ACL Reconstruction Surgery (March 10, 2022 8:00am) https://events.umich.edu/event/92953 92953-21698444@events.umich.edu Event Begins: Thursday, March 10, 2022 8:00am
Location: Off Campus Location
Organized By: LSA Opportunity Hub

Elective surgeries are necessary for healthcare because they are an important aspect of patient recovery and well-being. At a time when elective surgeries have been impacted significantly by the global pandemic, with either longer waiting periods or a cancellation altogether, the ability to schedule those potentially life-changing operations in advance has been compromised. Join us for a live look into an ACL reconstruction with BTB allograft surgery as Dr. Verma and his team use advanced surgical techniques to reconstruct a ruptured ACL

Dr. Verma is a Sports Medicine and Shoulder physician who performs over 500 procedures per year, and he specializes in treatment of the shoulder, elbow and knee with an emphasis on advanced arthroscopic reconstructive techniques. He is the Director of the Division of Sports Medicine and Director of the Sports Medicine Fellowship Program. In addition, Dr. Verma serves as a team physician for the Chicago White Sox and Chicago Bulls.

Have you ever wanted to view a live surgery? Has the global pandemic impacted your opportunity to shadow a physician at their clinical practice? Are you interested in exploring different medical fields? Then this event is for you!

You should attend this session if you are:

A liberal arts and/or science undergraduate student
Exploring careers and specialities in medicine and healthcare
Looking to understand more about the medical field from the perspective of a physician

What you’ll gain from attending:

The opportunity to watch a live surgery performed by a physician and his team using leading technology in the field
The chance to ask the physician questions about the surgery and his work more broadly
Gain insight into how the physicians are handling elective surgeries during COVID-19

RSVP today to reserve your spot to view the live surgery. Seats will be capped at 100. Once your RSVP is complete, you will receive a confirmation email with the event details and a link to access the live viewing before the event takes place.

The LSA Opportunity Hub aims to deliver inclusive and accessible experiences and welcomes all LSA students to participate. This event will be hosted on Zoom (learn more about Zoom accessibility) and can be accessed by phone or computer. Presentation materials will be shared in advance and live captioning will be provided. To request other accommodations please contact Paige Baker at paigebak@umich.edu or 734.763.4674. so we can make arrangements.

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Workshop / Seminar Thu, 03 Mar 2022 11:14:10 -0500 2022-03-10T08:00:00-05:00 2022-03-10T09:00:00-05:00 Off Campus Location LSA Opportunity Hub Workshop / Seminar
“Endemic” Defined: Its Impact on You, Health Care, and Society (March 10, 2022 12:00pm) https://events.umich.edu/event/93021 93021-21699124@events.umich.edu Event Begins: Thursday, March 10, 2022 12:00pm
Location: Off Campus Location
Organized By: Michigan Medicine

COVID-19 has permeated our lives for two years, and its impact on health care has been profound. While some uncertainty remains about future variants and immunity, we are potentially at a crossroads, moving to a new phase of the pandemic often described as endemic. But what does it mean and how will it shape health care and impact your loved ones?

Join Michigan Medicine experts from the Institute for Healthcare Policy and Innovation as we discuss effects of the pandemic and what we can expect moving forward.

Please submit questions for the Q&A when you RSVP at https://umich.formstack.com/forms/march_wellaware_rsvp?fbclid=IwAR0_j6ayOWZuzb1cM_EqcymSz0kmUGzed5eSGh7P7KbFpTVWuTOZdO-zwlk

The event features:

Kao-Ping Chua, M.D., Ph.D. - Assistant Professor of Pediatrics, U-M Medical Schoool, and Health Management and Policy, School of Public Heealth

Lindsay Kobayashi, Ph.D. - Assistant Professor of Epidemiology, School of Public Health

Emily Toth Martin, Ph.D., MPH - Associate Professor of Epidemiology, U-M School of Public Health

Lona Mody, M.D., the Amanda Sanford Hickey Collegiate Professor of Internal Medicine, Professor of Internal Medicine, Medical School, Professor of Epidemiology, School of Public Health, and Research Professor, Institute of Gerontology

Moderator: John Z. Ayanian, M.D., M.P.P., Director of the U-M Institute for Healthcare Policy and Innovation and the Alice Hamilton Distinguished University Professor of Medicine and Healthcare Policy

The event will also be livestreamed on Michigan Medicine social media channels

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Livestream / Virtual Fri, 04 Mar 2022 14:34:26 -0500 2022-03-10T12:00:00-05:00 2022-03-10T13:00:00-05:00 Off Campus Location Michigan Medicine Livestream / Virtual Well Aware "Endemic" promotional illustration - people in masks with thought bubbles and coronavirus particles
DCM&B Tools and Technology Seminar (March 10, 2022 12:00pm) https://events.umich.edu/event/89809 89809-21665887@events.umich.edu Event Begins: Thursday, March 10, 2022 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

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Presentation Tue, 07 Dec 2021 09:00:37 -0500 2022-03-10T12:00:00-05:00 2022-03-10T13:00:00-05:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
Biomechanics of the Female Reproductive System: Role of Smooth Muscle Contractility (March 10, 2022 3:30pm) https://events.umich.edu/event/92876 92876-21697628@events.umich.edu Event Begins: Thursday, March 10, 2022 3:30pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Abstract:
The tissues of the female reproductive system drastically remodel their shape and function in response to altered biomechanical and biochemical signals during processes such as pregnancy and aging. Tissue dynamics may include both passive remodeling of the extracellular matrix composition and organization, as well as the active response via changes in the amount, organization, and contractile response of smooth muscle cells.  Lack of adaptations in response to variable pressures may lead to structural instability in the female reproductive system, contributing to significant health problems, such as obstetric injury, preterm birth, and pelvic organ prolapse. The vagina is central to pelvic floor support; however, the relationship between vaginal extracellular matrix, smooth muscle contractility, and mechanical properties are not fully elucidated. In this talk, I will present our efforts to delineate the mechanical role of smooth muscle cells and potential interactions with elastic fibers in the murine vagina, and how these relationships evolve in a mouse model of pelvic organ prolapse and with reproductive age.

Bio:
Dr. Kristin S. Miller is an Associate Professor of Biomedical Engineering at Tulane University. Dr. Miller’s research interests are focused on the mechanobiology of soft tissues, including evaluating the role of elastic fibers and contractility in the female reproductive system. Before joining Tulane, Dr. Miller conducted postdoctoral research at Yale University and received her PhD in Bioengineering at the University of Pennsylvania. In 2018, Kristin was awarded the NSF CAREER award to develop a biomechanical model that can predict how elastic fibers in the soft tissues of the female reproductive system changes in response to mechanical pressure. In 2021, Kristin was awarded the YC Fung Early Career Award from the American Society of Mechanical Engineers.

Zoom Link: https://umich.zoom.us/j/96508834308

Organized by:
Dr. Brendon Baker,
Assistant Professor, Biomedical Engineering

Dr. David Nordsletten,
Associate Professor, Department of Biomedical Engineering and Cardiac Surgery

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Workshop / Seminar Tue, 01 Mar 2022 13:59:46 -0500 2022-03-10T15:30:00-05:00 2022-03-10T16:30:00-05:00 Off Campus Location Biomedical Engineering Workshop / Seminar BME Seminar
BioArtography - Call for Images (March 11, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701902@events.umich.edu Event Begins: Friday, March 11, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-11T00:00:00-05:00 2022-03-11T23:59:00-05:00 BioArtography Other U-M BioArtography
Data Science in Health Disparities Research Symposium (March 11, 2022 9:00am) https://events.umich.edu/event/91976 91976-21684826@events.umich.edu Event Begins: Friday, March 11, 2022 9:00am
Location: Palmer Commons
Organized By: DCMB Seminar Series

Additional speakers on the topics of:

How data science can be used to understand racial health disparities

How data science with biased data exacerbates health disparities

Lunch and discussion sessions following the talks.

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Workshop / Seminar Mon, 07 Feb 2022 10:37:38 -0500 2022-03-11T09:00:00-05:00 2022-03-11T15:00:00-05:00 Palmer Commons DCMB Seminar Series Workshop / Seminar
BioArtography - Call for Images (March 12, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701903@events.umich.edu Event Begins: Saturday, March 12, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-12T00:00:00-05:00 2022-03-12T23:59:00-05:00 BioArtography Other U-M BioArtography
BioArtography - Call for Images (March 13, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701904@events.umich.edu Event Begins: Sunday, March 13, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-13T00:00:00-05:00 2022-03-13T23:59:00-04:00 BioArtography Other U-M BioArtography
Project Management Certification (March 13, 2022 1:00pm) https://events.umich.edu/event/91083 91083-21676628@events.umich.edu Event Begins: Sunday, March 13, 2022 1:00pm
Location: Off Campus Location
Organized By: Tauber Institute for Global Operations

Once again, the Tauber Institute, in conjunction with the International Project Management Association (IPMA), is sponsoring a Project Management certification class and exam for graduate business and engineering students, alumni, and staff.

In order to participate, you will need to reflect upon a project management experience (for example: a work project, an engineering design experience/senior capstone, Ross' MAP project, Tauber team project, etc). If you cannot make it to the classes (due to project travel, MAP, or other another class), the sessions will be recorded. Homework (mastery verification) will be required after each session.

The cost to an individual to take the exam is normally $595, however, Tauber is offering the exam at a substantial discount to non-Tauber students:
$550 for U-M alumni or public
$425 for U-M students, U-M employees, or Tauber alumni
$325 for U-M Ross School of Business or U-M College of Engineering staff
$225 for Tauber Institute students
$145 for previous students to retake the exam

Certification is valid for 5 years. Three certification classes will be taught by Professor Eric Svaan on the following dates:

Sunday, March 13 (1:00 pm - 4:00 pm)
Sunday, March 27 (1:00 pm - 4:00 pm)
Sunday, April 10 (1:00 pm - 4:00 pm)

The certification exam, administered by IPMA-USA is scheduled for May 1, 2022 (11:00 am) virtually. Successfully passing the exam will yield IPMA's Level D certification (Certified Project Management Associate).

Project Management is a powerful skill set to have in your toolbox as you look for full-time employment!

REGISTRATION: Please register through iMpact by clicking here:
https://www.bus.umich.edu/Conferences/Project-Management-Certification-2022/Default.aspx

NOTE: The non-refundable fees

HOSTED BY: Tauber Institute for Global Operations. For questions about this event, please contact tauberinstitute@umich.edu or visit tauber.umich.edu.

What is IPMA Level D® (Certified Project Management Associate)? The IPMA Level D is an internationally recognized entry-level qualification in the area of project management. This designation, which demonstrates the individual's ability to understand the basics of project management, is similar to the exam-oriented, knowledge-based certifications of other major Project Management associations. For many, Level D® is the first step towards a professional project or program manager role. It is the first step in a sequence (C, B and A) to be earned by demonstration of success in larger PM responsibility sets.

For more information,
Visit tauber.umich.edu or call 734-647-1333
Connect via email to Diana Crossley dianak@umich.edu

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Class / Instruction Mon, 21 Feb 2022 15:54:30 -0500 2022-03-13T13:00:00-04:00 2022-03-13T16:00:00-04:00 Off Campus Location Tauber Institute for Global Operations Class / Instruction Certificate photo
BioArtography - Call for Images (March 14, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701905@events.umich.edu Event Begins: Monday, March 14, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-14T00:00:00-04:00 2022-03-14T23:59:00-04:00 BioArtography Other U-M BioArtography
Caswell Diabetes Institute Seminar Series (March 14, 2022 12:00pm) https://events.umich.edu/event/93237 93237-21701924@events.umich.edu Event Begins: Monday, March 14, 2022 12:00pm
Location: Off Campus Location
Organized By: Caswell Diabetes Institute

The Caswell Diabetes Institute Seminar Series features plenary seminar events addressing the broad interests in diabetes-, obesity-, metabolism-, and complications-related research and care across the University of Michigan campus and worldwide.

Prof Andrew Hattersley FRS is an outstanding clinical scientist, who is distinguished for his contributions to the understanding of the genetics of diabetes and the application of that knowledge to clinical practice. He became Gillings Chair in Precision Medicine at Exeter in 2015 and leads the Precision medicine initiative at the University of Exeter working with both scientific and clinical colleagues.

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Livestream / Virtual Thu, 10 Mar 2022 09:25:53 -0500 2022-03-14T12:00:00-04:00 2022-03-14T13:00:00-04:00 Off Campus Location Caswell Diabetes Institute Livestream / Virtual Hattersley CDI Seminar Notice
Why medicine? Med school personal statement workshop. (March 14, 2022 3:00pm) https://events.umich.edu/event/92335 92335-21690197@events.umich.edu Event Begins: Monday, March 14, 2022 3:00pm
Location:
Organized By: LSA Honors Program

Looking for feedback on your med-school application essays or personal statement for other opportunities? Join Honors advisor Margo Kolenda-Mason and get fresh eyes on your personal statements. This session will run on a peer-review workshop model, so be prepared to bring and share your writing with other students.

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Workshop / Seminar Mon, 14 Feb 2022 11:14:57 -0500 2022-03-14T15:00:00-04:00 2022-03-14T16:00:00-04:00 LSA Honors Program Workshop / Seminar work flow
BioArtography - Call for Images (March 15, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701906@events.umich.edu Event Begins: Tuesday, March 15, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-15T00:00:00-04:00 2022-03-15T23:59:00-04:00 BioArtography Other U-M BioArtography
Integrating intersectionality into Environmental Health Sciences (March 15, 2022 12:00pm) https://events.umich.edu/event/92997 92997-21698985@events.umich.edu Event Begins: Tuesday, March 15, 2022 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

*Registered required.

Ami Zota, ScD, MS, is an Associate Professor in the Department of Environmental & Occupational Health at George Washington University's Milken School of Public Health. Dr. Zota’s work seeks to secure environmental justice and improve health equity through advancements in science, policy, and clinical practice. Her research identifies novel pathways linking social disparities, environmental exposures, and reproductive and children’s health.

The environmental research seminar series is organized by the Integrated Health Sciences Core of the Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD). More information about M-LEEaD and upcoming events can be found here: http://mleead.umich.edu/index.php

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Lecture / Discussion Fri, 04 Mar 2022 09:34:10 -0500 2022-03-15T12:00:00-04:00 2022-03-15T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Integrating intersectionality into Environmental Health Sciences
Why medicine? Med school personal statement workshop. (March 15, 2022 5:00pm) https://events.umich.edu/event/92335 92335-21690198@events.umich.edu Event Begins: Tuesday, March 15, 2022 5:00pm
Location: Off Campus Location
Organized By: LSA Honors Program

Looking for feedback on your med-school application essays or personal statement for other opportunities? Join Honors advisor Margo Kolenda-Mason and get fresh eyes on your personal statements. This session will run on a peer-review workshop model, so be prepared to bring and share your writing with other students.

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Workshop / Seminar Mon, 14 Feb 2022 11:14:57 -0500 2022-03-15T17:00:00-04:00 2022-03-15T18:00:00-04:00 Off Campus Location LSA Honors Program Workshop / Seminar work flow
Med Madness with Oakland University William Beaumont School of Medicine! (March 15, 2022 6:00pm) https://events.umich.edu/event/93210 93210-21701537@events.umich.edu Event Begins: Tuesday, March 15, 2022 6:00pm
Location: Off Campus Location
Organized By: MAPS (Multicultural Association for Pre-health Students)

Come join us to hear from Ben Malamet, a U-M alumnus and current 4th-year medical student from the Oakland University William Beaumont School of Medicine! Learn all about what Oakland has to offer and get your questions answered! This is part of MedMadness, our month-long information sessions with Medical School representatives across Michigan.

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Workshop / Seminar Wed, 09 Mar 2022 16:03:50 -0500 2022-03-15T18:00:00-04:00 2022-03-15T19:00:00-04:00 Off Campus Location MAPS (Multicultural Association for Pre-health Students) Workshop / Seminar event flyer
BioArtography - Call for Images (March 16, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701907@events.umich.edu Event Begins: Wednesday, March 16, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-16T00:00:00-04:00 2022-03-16T23:59:00-04:00 BioArtography Other U-M BioArtography
2022 Precision Health Symposium (March 16, 2022 8:00am) https://events.umich.edu/event/91836 91836-21683225@events.umich.edu Event Begins: Wednesday, March 16, 2022 8:00am
Location: North Campus Research Complex Building 18
Organized By: Precision Health

Join us for a half-day, in-person event (with remote option) that will focus on the transformative impact artificial intelligence and machine learning are having on precision healthcare. Attendees will hear from thought leaders, researchers, and practitioners who will guide the conversation from big picture concepts, to the importance of applying new research tools responsibly and inclusively, to the need for integrating new methods and inclusivity considerations into training for clinicians, researchers, and other learners.

Keynote Speaker: Bob Wachter

Featured Speakers: Akbar Waljee, Lionel Robert, Jodyn Platt

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Workshop / Seminar Mon, 07 Mar 2022 16:32:48 -0500 2022-03-16T08:00:00-04:00 2022-03-16T12:00:00-04:00 North Campus Research Complex Building 18 Precision Health Workshop / Seminar Precision Health Symposium
Why medicine? Med school personal statement workshop. (March 16, 2022 2:30pm) https://events.umich.edu/event/92335 92335-21690199@events.umich.edu Event Begins: Wednesday, March 16, 2022 2:30pm
Location: Off Campus Location
Organized By: LSA Honors Program

Looking for feedback on your med-school application essays or personal statement for other opportunities? Join Honors advisor Margo Kolenda-Mason and get fresh eyes on your personal statements. This session will run on a peer-review workshop model, so be prepared to bring and share your writing with other students.

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Workshop / Seminar Mon, 14 Feb 2022 11:14:57 -0500 2022-03-16T14:30:00-04:00 2022-03-16T15:30:00-04:00 Off Campus Location LSA Honors Program Workshop / Seminar work flow
Redefine Success: Reach Out, Reduce Stress (March 16, 2022 6:00pm) https://events.umich.edu/event/87835 87835-21647060@events.umich.edu Event Begins: Wednesday, March 16, 2022 6:00pm
Location: Off Campus Location
Organized By: Michigan Medicine Wellness Office

Learn strategies to reduce stress, identify how and when to reach out for help, and consider how redefining success can positively impact your life.

Please register to receive zoom link: https://sessions.studentlife.umich.edu/track/event/session/45699

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Well-being Mon, 04 Oct 2021 11:46:17 -0400 2022-03-16T18:00:00-04:00 2022-03-16T19:00:00-04:00 Off Campus Location Michigan Medicine Wellness Office Well-being Wellness Office Logo
BioArtography - Call for Images (March 17, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701908@events.umich.edu Event Begins: Thursday, March 17, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-17T00:00:00-04:00 2022-03-17T23:59:00-04:00 BioArtography Other U-M BioArtography
“The Salivary Glands: Robust Sites for Infection and Transmission of SARS-CoV-2” (March 17, 2022 12:00pm) https://events.umich.edu/event/92751 92751-21695193@events.umich.edu Event Begins: Thursday, March 17, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

BIOGRAPHY
Born: August 3rd, 1981, Defiance, Ohio, United States of America

LICENSES & CERTIFICATIONS
Diplomate, Oral and Maxillofacial Pathology – American Board of Oral and Maxillofacial Pathology
Dental License(s) – Unrestricted Dental License, Commonwealth of Pennsylvania, DS039850
DEA Registration – US Department of Justice
CPR Certification – American Red Cross

HONORS, AWARDS, & NOTEWORTHY INVITED TALKS.
2021 American College of Rheumatology Convergence, Invited Speaker, “Epigenetics of Sjogren’s Syndrome.” November 2021. >600 Attendees/Views.

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Lecture / Discussion Tue, 01 Mar 2022 11:08:51 -0500 2022-03-17T12:00:00-04:00 2022-03-17T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Lecture / Discussion Blake Warner, DDS, PhD, MPH Assistant Clinical Investigator Chief of the Salivary Disorders Unit and the Sjogren’s Syndrome Clinic NIH National Institute of Dental and Craniofacial Research
DCM&B Tools and Technology Seminar (March 17, 2022 12:00pm) https://events.umich.edu/event/89810 89810-21665888@events.umich.edu Event Begins: Thursday, March 17, 2022 12:00pm
Location: Off Campus Location
Organized By: DCMB Tools and Technology Seminar

This presentation will be remote only via Zoom

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Presentation Mon, 07 Mar 2022 13:13:54 -0500 2022-03-17T12:00:00-04:00 2022-03-17T13:00:00-04:00 Off Campus Location DCMB Tools and Technology Seminar Presentation
BioArtography - Call for Images (March 18, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701909@events.umich.edu Event Begins: Friday, March 18, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-18T00:00:00-04:00 2022-03-18T23:59:00-04:00 BioArtography Other U-M BioArtography
Pre-Clinical Investigation of Histotripsy for Non-Invasive Ablation of Liver Cancer (March 18, 2022 1:30pm) https://events.umich.edu/event/92996 92996-21698984@events.umich.edu Event Begins: Friday, March 18, 2022 1:30pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Liver cancer, including hepatocellular carcinoma (HCC) is one of the top ten causes of cancer related deaths worldwide and in the United States. The liver is also a frequent site for metastases originating from colorectal cancer, pancreatic cancer, melanoma, lung cancer and breast cancer. Depending on the location, severity and staging of liver cancer, multiple treatment options are currently available including surgical resection, liver transplantation, chemotherapy, radiation therapy, targeted drug therapy, immunotherapies, and ablation techniques including radiofrequency ablation (RFA), microwave ablation (MWA), cryoablation, high intensity focused ultrasound (HIFU), yet the prognosis of HCC remains poor with five-year survival rates reported at only 18% in the US. Even after treatment, the high prevalence of tumor recurrence and metastasis highlights the clinical need for improving outcomes of liver cancer.

Histotripsy is a novel non-invasive, non-ionizing, and non-thermal ablation technique that mechanically destroys target tissue by controlled acoustic cavitation. High pressure (p->30MPa), microsecond-length ultrasound pulses cause endogenous nanometer-scale gas nuclei in the target tissue to rapidly expand and collapse, generating high mechanical stress and strain to disrupt the cellular structure into an acellular homogenate. This dissertation investigates histotripsy as a therapeutic ultrasound treatment option of liver cancer and other solid tumors.

The first study evaluated the safety and feasibility and survival benefits of histotripsy in an in vivo murine liver tumor model. Results showed that non-invasive histotripsy ablation reduced local tumor progression of subcutaneous human-derived HCC tumor and improved survival outcomes in immunocompromised mice. This study also characterized the radiological features correlating to the histotripsy tumor response.

The second study investigated the anti-tumor immune response generated by histotripsy ablation of subcutaneous murine melanoma and HCC tumors. Histotripsy stimulated potent local intratumoral infiltration of innate and adaptive immune cell populations, promoted abscopal immune responses at untreated tumor sites and inhibited growth of pulmonary metastases. Histotripsy was capable of releasing tumor antigens with retained immunogenicity and was able to amplify the efficacy of checkpoint inhibition immunotherapy.

The third study evaluated the safety, feasibility, and tumor volume reduction effects of histotripsy for liver cancer ablation in an orthotopic, immune-competent in vivo rat HCC model. For the first time, it was demonstrated that complete as well as partial histotripsy ablation of tumors can result in complete tumor regression with no recurrence.

The fourth study evaluated the effects of partial histotripsy tumor ablation on tumor response, risk of metastases and immune infiltration in an orthotopic, immunocompetent, metastatic rodent hepatocellular carcinoma (HCC) model. Results showed that histotripsy significantly improved survival outcomes with no increased risk of metastasis compared to controls and demonstrated that augmented tumor immune infiltration may have contributed to the eventual regression even with partial treatment of tumors.

The fifth study compared the safety, tumor response and survival outcomes between single and repeat histotripsy treatments of human-derived HCC tumors in immunocompromised murine hosts and mouse-derived HCC tumors in immunocompetent murine hosts. One week after the initial histotripsy treatment, animals received a repeat histotripsy treatment. Results showed that while both histotripsy groups significantly improved survival outcomes over control, the repeat histotripsy group demonstrated slower tumor growth and increased survival compared to single histotripsy.

Overall, this dissertation demonstrated the potential and in vivo feasibility of histotripsy for successful non-invasive tumor ablation, reduction of local tumor burden and prevention of metastasis. Future studies will continue to investigate the safety, efficacy, and biological effects of histotripsy liver cancer treatment for potential translation to clinic.

Date: Friday, March 18, 2022
Time: 1:30 PM EST
Zoom: https://umich.zoom.us/j/95042725076 Passcode: EarthPass
Chair: Professor Zhen Xu

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Presentation Fri, 04 Mar 2022 09:28:05 -0500 2022-03-18T13:30:00-04:00 2022-03-18T14:30:00-04:00 Off Campus Location Biomedical Engineering Presentation BME PhD Defense
BioArtography - Call for Images (March 19, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701910@events.umich.edu Event Begins: Saturday, March 19, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-19T00:00:00-04:00 2022-03-19T23:59:00-04:00 BioArtography Other U-M BioArtography
2022 University of Michigan Brain Bee (March 19, 2022 12:00pm) https://events.umich.edu/event/92806 92806-21695825@events.umich.edu Event Begins: Saturday, March 19, 2022 12:00pm
Location: Michigan League
Organized By: Michigan Brain Bee

The university of Michigan Brain Bee is a neuroscience competition open to all Michigan students in grades 9-12! The winner of the Michigan Brain Bee will win 250$ and the right to represent Michigan in the National Brain Bee, held remotely on April 9th, 2022. To learn more information and to register please see the link below!
https://sites.google.com/umich.edu/brainbee

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Fair / Festival Fri, 25 Feb 2022 14:39:38 -0500 2022-03-19T12:00:00-04:00 2022-03-19T17:00:00-04:00 Michigan League Michigan Brain Bee Fair / Festival Michigan Brain Bee Logo
BioArtography - Call for Images (March 20, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701911@events.umich.edu Event Begins: Sunday, March 20, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-20T00:00:00-04:00 2022-03-20T23:59:00-04:00 BioArtography Other U-M BioArtography
BioArtography - Call for Images (March 21, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701912@events.umich.edu Event Begins: Monday, March 21, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-21T00:00:00-04:00 2022-03-21T23:59:00-04:00 BioArtography Other U-M BioArtography
Approaches to Prevascularize Pancreatic Islets: A Preliminary Study for Diabetic Cell Therapy (March 21, 2022 3:00pm) https://events.umich.edu/event/93457 93457-21704627@events.umich.edu Event Begins: Monday, March 21, 2022 3:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

This research is seeking to examine two approaches to vascularize a scaffold material, toward the goal of engineering a prevascularized islet implant. Type 1 diabetes mellitus (T1DM) is a chronic condition that affects millions of people worldwide. It is indicated by the autoimmune destruction of beta cells within pancreatic islets which results in significantly decreased or no production of insulin. Without enough insulin, the body cannot maintain healthy blood glucose levels, and this deficiency can lead to a range of other issues. A previous cell therapy method has been established to attempt to permanently cure T1DM, but the need for harsh immunosuppressive drugs, as well as poor vascularization, keep this protocol from being widely used. The scaffold vascularization strategies utilized in this research aim to mitigate the negative aspects of this preceding protocol.

The first part of this study characterized the effects of cell-specific media formulations on in vitro endothelial network development. In these experiments, hybrid media formulations containing varying ratios of vascular growth medium and beta cell medium were used to culture cellular fibrin hydrogels for 5 and 7 days. 3D vessel density analysis was performed for each gel, and the results showed that increasing the amount of beta cell medium in the gel culture media significantly decreased overall vessel density, and decreased vessel growth between day 5 and 7.

The second part of this study evaluated how the extent of in vitro endothelial network development in 3D fibrin hydrogels was affected by applying a modular tissue engineering strategy. Cellular fibrin microbeads were fabricated for this experiment. One group was immediately embedded into fibrin hydrogels, and a second group was kept in preculture for 5 days before being embedded. These embedded hydrogels were allowed to culture for 7 days before being analyzed for extent of vascularization. Average vessel sprout lengths were determined for each experimental group and compared, and the results of this study showed that the precultured microbeads were able to sprout statistically significantly longer vessels than non-precultured microbeads by the end of the 7-day culture period.

These studies help to demonstrate directions that could be pursued to develop a successful method for pre-vascularizing islet implants. The islet beta cell medium is not well suited for vascularization strategies because it lacks growth factors and supplements needed for endothelial network development. Because the islet’s media environment is incompatible with direct endothelial network growth, utilizing a precultured microtissue within an islet-containing hydrogel could aid in network growth even with beta cell medium. The microtissue itself serves as a temporary environment for an endothelial network to form before being exposed to beta medium, and the preformed endothelial network is beneficial in promoting vessel sprouting mechanisms and secreting proangiogenic factors lacking in the beta cell medium. Overall, incorporating precultured microtissues to vascularize islets could be a promising step towards treating T1DM.

DATE: Monday, March 21, 2002
TIME: 3:00 PM
Zoom: https://umich.zoom.us/j/8624071458 (Passcode: 932317)
Chair: Prof. Jan Stegemann

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Lecture / Discussion Tue, 15 Mar 2022 15:21:55 -0400 2022-03-21T15:00:00-04:00 2022-03-21T16:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Master's Defense
Med Madness with MSU College of Human Medicine! (March 21, 2022 6:00pm) https://events.umich.edu/event/93627 93627-21706443@events.umich.edu Event Begins: Monday, March 21, 2022 6:00pm
Location: Off Campus Location
Organized By: MAPS (Multicultural Association for Pre-health Students)

Come join us to hear from Elizabeth Guerrero Lyons, the Director of Multicultural Recruitment at the Michigan State University College of Human Medicine! Learn all about what MSU's MD program has to offer and get all your pre-med questions answered! This is part of MedMadness, our month-long information sessions with Medical School representatives across Michigan.

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Workshop / Seminar Fri, 18 Mar 2022 17:50:43 -0400 2022-03-21T18:00:00-04:00 2022-03-21T19:00:00-04:00 Off Campus Location MAPS (Multicultural Association for Pre-health Students) Workshop / Seminar event flyer
BioArtography - Call for Images (March 22, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701913@events.umich.edu Event Begins: Tuesday, March 22, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-22T00:00:00-04:00 2022-03-22T23:59:00-04:00 BioArtography Other U-M BioArtography
LHS Collaboratory (March 22, 2022 12:00pm) https://events.umich.edu/event/90095 90095-21667763@events.umich.edu Event Begins: Tuesday, March 22, 2022 12:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Presentation 1: PCORNet and the PaTH subnetwork

Kathleen McTigue, MD, MPH, MS

In this talk, Kathleen McTigue describes the vision of PCORNet, its organization, and its value to the field of clinical research. PCORNet is divided into regional subnetworks one of which is PaTH. The organization of PaTH along with its priories will be discussed.

Presentation 2: UM’s site within PCORNet/PaTH

David Williams, PhD

The University of Michigan is an institutional member of PaTH/PCORNet.
In this talk, David Williams describes the organization and processes of the UM site within PCORNet/PaTH, studies in which UM participates, and resources for UM investigators interested in participating in PCORNet studies.

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Lecture / Discussion Wed, 15 Dec 2021 22:38:45 -0500 2022-03-22T12:00:00-04:00 2022-03-22T13:30:00-04:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion Collaboratory logo
Operationalizing the exposome through chemical surveillance & bioeffect monitoring with high-resolution mass spectrometry (March 22, 2022 12:00pm) https://events.umich.edu/event/93450 93450-21704620@events.umich.edu Event Begins: Tuesday, March 22, 2022 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Registration required https://umich.zoom.us/webinar/register/WN_wum4p_pdRMKIixVZJAlicg

Douglas Walker is assistant professor in the Dept of Environmental Medicine & Public Health, Icahn School of Medicine, Mount Sinai. Dr. Walker's research is focused on using untargeted metabolomics to measure environmental exposures, and how exposures lead to biological changes that cause diseases. During his postdoctoral fellowship at Emory University, he acted as Director of Exposome Research for the Clinical Biomarkers Laboratory and was a member of the HERCULES Exposome Research Center. Through application of high-resolution mass spectrometry platforms, Dr. Walker has shown it is possible to provide measures of 10,000-100,000 chemical signals in a cost-effective manner using a single human blood sample, providing a key advance for nutritional assessment, precision medicine and exposome research. At Mount Sinai, his research will be focus on continued development and application of advanced analytical strategies for measuring the occurrence, distribution and magnitude of previously unidentified environmental exposures and assist in delineating the mechanisms underlying environment-related diseases in humans.

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Lecture / Discussion Tue, 15 Mar 2022 13:21:33 -0400 2022-03-22T12:00:00-04:00 2022-03-22T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Dr. Douglas Walker (Mt. Sinai) presents the M-LEEaD Environmental Research Seminar
BioArtography - Call for Images (March 23, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701914@events.umich.edu Event Begins: Wednesday, March 23, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-23T00:00:00-04:00 2022-03-23T23:59:00-04:00 BioArtography Other U-M BioArtography
BioArtography - Call for Images (March 24, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701915@events.umich.edu Event Begins: Thursday, March 24, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-24T00:00:00-04:00 2022-03-24T23:59:00-04:00 BioArtography Other U-M BioArtography
DCM&B Tools and Technology Seminar (March 24, 2022 12:00pm) https://events.umich.edu/event/89811 89811-21665889@events.umich.edu Event Begins: Thursday, March 24, 2022 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

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Presentation Tue, 07 Dec 2021 09:06:13 -0500 2022-03-24T12:00:00-04:00 2022-03-24T13:00:00-04:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
Biomechanical Strain Sensors and FRESH 3D Bioprinted Microfluidics for Tissue Engineering and Disease Modeling (March 24, 2022 3:30pm) https://events.umich.edu/event/93522 93522-21705224@events.umich.edu Event Begins: Thursday, March 24, 2022 3:30pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: Biomedical Engineering

Abstract:
The pursuit of an ideal model system to study the pathophysiology of vascular disease has included the use of tissue engineered blood vessels (TEBV), vascularizing engineered volumetric tissue, silicone-based “organ-on-a-chip” platforms, and tissue decellularization; yet we are still far from generating engineered vascular tissue that recapitulates native physiology. 3D bioprinting has led to additive manufacturing approaches for creating fluidic channels; however, it remains challenging to produce continuous networks with vessels ranging from large (>6 mm) to small (<1 mm) diameter using soft native-like extracellular matrix (ECM) that mimics the mechanical properties, geometric organization, and compositional complexity of the cellular and extracellular microenvironment. An ideal engineering strategy would combine the advantages of additive manufacturing with the controlled fluid flow achieved by organ-on-a-chip platforms, and the ECM structure, composition, and biomechanics of decellularized tissue. In this presentation I will highlight recent work on developing i) a fluorescence-based mechanical strain sensor for mapping 3D surface strain of contractile cells, developing tissue, and engineered blood vessels, ii) 3D bioprinted ECM microfluidics using Freeform Reversible Embedding of Suspended Hydrogels (FRESH), and iii) an in-process imaging platform for error detection and 3D gauging using optical coherence tomography (OCT). Together, this work highlights the exciting potential for FRESH printed ECM-based microfluidic scaffolds and vascular tissue engineering that will set the foundation for future work studying how ECM composition, mechanical properties, and fluid flow contribute to vascular disease. In addition to vascular biology, the collagen-based microfluidics and fluorescence strain sensor are platform technologies amenable to other organ systems, and can be utilized to study cell proliferation, metastasis, ECM remodeling, and biomechanics in a 3D environment.
Bio:
Dr. Shiwarski received a B.S. in Cell Biology and Biochemistry from Bucknell University and a Ph.D. in Biology and Neuroscience from Carnegie Mellon University. During his doctoral research, he investigated how opioid receptor membrane trafficking events influence pain inhibition and opioid addiction using advanced live cell fluorescence imaging and analysis techniques to track exocytic and endocytic events. In 2017 he began a postdoctoral fellowship in Dr. Adam Feinberg’s Lab in the Department of Biomedical Engineering at Carnegie Mellon University where he has: 1) studied how biomechanical forces are essential for cellular and tissue physiology by developing a fluorescence-based nanomechanical biosensor to map real-time changes in cell and tissue strain, 2) was a key contributor on the development of the 3D bioprinting technology FRESH 2.0,  which provided the ability to print unmodified collagen into functional components of the human heart, and 3) designed and published a series of open-source hardware and software platforms for 3D bioprinting, bi-axial mechanical testing, and in-process monitoring for additive manufacturing. Dr. Shiwarski has a broad background in cell biology, quantitative imaging, and tissue engineering with specific expertise in live cell fluorescence imaging, cellular biosensors, computational image analysis, 3D bioprinting, and cellular biomechanics. His future work focuses on engineering FRESH printed ECM-based microfluidic scaffolds as a platform technology for vascular tissue engineering that will set the foundation for studying how vascular smooth muscle cell differentiation, ECM composition, mechanical properties, and fluid flow contribute to hypertensive vascular disease. 

Zoom Link: https://umich.zoom.us/j/96508834308

Organized by:
Dr. Brendon Baker,
Assistant Professor, Biomedical Engineering

Dr. David Nordsletten,
Associate Professor, Department of Biomedical Engineering and Cardiac Surgery

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Workshop / Seminar Wed, 16 Mar 2022 14:21:05 -0400 2022-03-24T15:30:00-04:00 2022-03-24T16:30:00-04:00 Lurie Biomedical Engineering (formerly ATL) Biomedical Engineering Workshop / Seminar BME Seminar
BioArtography - Call for Images (March 25, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701916@events.umich.edu Event Begins: Friday, March 25, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-25T00:00:00-04:00 2022-03-25T23:59:00-04:00 BioArtography Other U-M BioArtography
6th Annual RNA Symposium (March 25, 2022 8:00am) https://events.umich.edu/event/93125 93125-21700908@events.umich.edu Event Begins: Friday, March 25, 2022 8:00am
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

Symposium Agenda

8:30 / Morning Welcome: President Mary Sue Coleman
8:40 / Jack Szostak "The emergence of RNA from heterogeneous prebiotic chemistry"
9:35 / Gigi Storz "RNA-mediated regulation within protein-coding sequences"
10:30 / coffee break
10:55 / Chris Burge "Impact of RNA-Binding Proteins on Human Genomic Variation"
12:00 / Lunch - please register for free box lunch
1:00 / Afternoon Welcome: Rebecca Cunningham, Vice President for Research
1:10 / Wendy Gilbert “Decoding the untranslated”
2:05 / Michelle Hastings "Splice-Modulating Antisense Oligonucleotides for the Treatment of Disease"
2:55 / Panel discussion with keynote speakers
Topic: Future of RNA Therapeutics, moderated by John Androsavich, Pfizer Global Lead, RNA Medicine

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Lecture / Discussion Wed, 16 Mar 2022 15:43:32 -0400 2022-03-25T08:00:00-04:00 2022-03-25T16:00:00-04:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion 6th Annual RNA Symposium
Beneficial virus: evolutionary, modeling & clinical perspectives on phage (March 25, 2022 9:00am) https://events.umich.edu/event/88027 88027-21648632@events.umich.edu Event Begins: Friday, March 25, 2022 9:00am
Location: Rackham Graduate School (Horace H.)
Organized By: MAC-EPID

SPEAKERS INCLUDE:

Stephanie Strathdee, PhD (Associate Dean of Global Health Sciences; Harold Simon Professor, UCSD Department of Medicine; Co-Director, Center for Innovative Phage Applications and Therapeutics; Author of The Perfect Predator)

Vivek Mutalik, PhD (Staff Scientist, Environmental Genomics and Systems Biology: Comparative and Functional Genomics; Biological Systems and Engineering: Organismal Systems & Bioresilience, Biodesign at Lawrence Berkeley National Laboratory)

Samuel Brown, PhD (Professor, Georgia Tech Biological Sciences)

Gina Suh, M.D. (Senior Associate Consultant, Division of Infectious Diseases, Department of Internal Medicine. Assistant Professor of Medicine, Mayo Clinic)

* * * * *
Coffee hour directly following talks.
Please register for this free symposium since lunch will be provided. Thank you!

For more information and registration for this FREE event:
www.MAC-EPID.org
Anna Cronenwett, weaverd@umich.edu

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Conference / Symposium Thu, 07 Oct 2021 13:05:57 -0400 2022-03-25T09:00:00-04:00 2022-03-25T16:00:00-04:00 Rackham Graduate School (Horace H.) MAC-EPID Conference / Symposium Event Flyer
Mechanisms of Action and Sources of Variability in Neurostimulation for Chronic Pain (March 25, 2022 12:00pm) https://events.umich.edu/event/93458 93458-21704629@events.umich.edu Event Begins: Friday, March 25, 2022 12:00pm
Location: North Campus Research Complex Building 10
Organized By: Biomedical Engineering

Chronic pain is a debilitating neurological disorder which affects hundreds of millions of people worldwide. Neurostimulation therapies, such as spinal cord stimulation (SCS) and dorsal root ganglion stimulation (DRGS), are non-addictive alternatives for managing chronic neuropathic pain that is refractory to conventional medical management. SCS and DRGS apply sequences of brief electrical impulses to neural tissue. However, not all patients receiving these therapies obtain adequate pain relief, and patient outcomes are not improving despite decades of clinical experience and advancements in stimulation technology. This dissertation addresses two crucial knowledge gaps limiting the success of neurostimulation therapies: 1) we do not understand the physiological mechanisms of electrical stimulation-induced pain relief, and 2) we do not understand the sources of variability affecting the neural response to stimulation.

The first portion of this thesis examined the mechanisms of action of DRGS. We developed statistical models of neural element (i.e., cell bodies, axons) locations in histological samples of human dorsal root ganglia (DRG) tissue. Next, we employed a histologically informed field-cable modeling approach to study the neural response to DRGS. We coupled a finite element method model of the potential distribution generated by DRGS to multi-compartment cable models of DRG neurons to simulate which types of sensory neurons are activated by therapeutic DRGS. Our data suggest that clinical DRGS directly activates the subset of sensory neurons that code non-painful touch sensations, which may trigger pain-inhibition neural networks in the spinal cord dorsal horn.

The second portion of this thesis investigated how biological variability at different scales (e.g., single cells, patient anatomy) affected the neural response to stimulation. We implemented a Markov Chain Monte Carlo (MCMC) method to parametrize populations of neurons with heterogeneous ion channel expression profiles. We incorporated this approach in our field-cable model of DRGS and showed that variability in ion channel expression can affect the stimulation amplitude required to generate activity in target neurons. We further applied this population-modeling approach to investigate how pathology induced changes in ion channel expression can affect the behavior of neural circuits governing sensory transmission. Finally, we developed a framework for constructing patient-specific field-cable models of patients receiving SCS. This framework captured the effect of key anatomical details (e.g., the amount of cerebrospinal fluid between a patient’s SCS electrode array and the spinal cord) on neural activation during stimulation. Furthermore, this patient-specific modeling framework allows the comparison of model predictions of neural activation during SCS with clinical data, such as patient-reported outcomes (e.g., pain relief).

The results of this dissertation suggest that DRGS may share mechanisms of action with other neurostimulation therapies for pain management, such as SCS. This dissertation also developed frameworks for studying the effect of biological variability on the nervous system’s response to electrical stimulation. To develop safe and effective therapies for neurological disorders, it is crucial to understand both the physiological mechanisms of symptom relief, and how the neural response to therapy may vary across cells, circuits, and patients. This dissertation provides novel insights on both aspects as they relate to neurostimulation for chronic pain.

Date: Friday, March 25, 2022
Time: 12:00 PM EST
Zoom link: https://umich.zoom.us/j/93382361344 (password: neuron)
Chair: Dr. Scott F. Lempka

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Class / Instruction Tue, 15 Mar 2022 15:42:02 -0400 2022-03-25T12:00:00-04:00 2022-03-25T13:00:00-04:00 North Campus Research Complex Building 10 Biomedical Engineering Class / Instruction BME PhD Defense
BioArtography - Call for Images (March 26, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701917@events.umich.edu Event Begins: Saturday, March 26, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-26T00:00:00-04:00 2022-03-26T23:59:00-04:00 BioArtography Other U-M BioArtography
BioArtography - Call for Images (March 27, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701918@events.umich.edu Event Begins: Sunday, March 27, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-27T00:00:00-04:00 2022-03-27T23:59:00-04:00 BioArtography Other U-M BioArtography
Project Management Certification (March 27, 2022 1:00pm) https://events.umich.edu/event/91083 91083-21677007@events.umich.edu Event Begins: Sunday, March 27, 2022 1:00pm
Location: Off Campus Location
Organized By: Tauber Institute for Global Operations

Once again, the Tauber Institute, in conjunction with the International Project Management Association (IPMA), is sponsoring a Project Management certification class and exam for graduate business and engineering students, alumni, and staff.

In order to participate, you will need to reflect upon a project management experience (for example: a work project, an engineering design experience/senior capstone, Ross' MAP project, Tauber team project, etc). If you cannot make it to the classes (due to project travel, MAP, or other another class), the sessions will be recorded. Homework (mastery verification) will be required after each session.

The cost to an individual to take the exam is normally $595, however, Tauber is offering the exam at a substantial discount to non-Tauber students:
$550 for U-M alumni or public
$425 for U-M students, U-M employees, or Tauber alumni
$325 for U-M Ross School of Business or U-M College of Engineering staff
$225 for Tauber Institute students
$145 for previous students to retake the exam

Certification is valid for 5 years. Three certification classes will be taught by Professor Eric Svaan on the following dates:

Sunday, March 13 (1:00 pm - 4:00 pm)
Sunday, March 27 (1:00 pm - 4:00 pm)
Sunday, April 10 (1:00 pm - 4:00 pm)

The certification exam, administered by IPMA-USA is scheduled for May 1, 2022 (11:00 am) virtually. Successfully passing the exam will yield IPMA's Level D certification (Certified Project Management Associate).

Project Management is a powerful skill set to have in your toolbox as you look for full-time employment!

REGISTRATION: Please register through iMpact by clicking here:
https://www.bus.umich.edu/Conferences/Project-Management-Certification-2022/Default.aspx

NOTE: The non-refundable fees

HOSTED BY: Tauber Institute for Global Operations. For questions about this event, please contact tauberinstitute@umich.edu or visit tauber.umich.edu.

What is IPMA Level D® (Certified Project Management Associate)? The IPMA Level D is an internationally recognized entry-level qualification in the area of project management. This designation, which demonstrates the individual's ability to understand the basics of project management, is similar to the exam-oriented, knowledge-based certifications of other major Project Management associations. For many, Level D® is the first step towards a professional project or program manager role. It is the first step in a sequence (C, B and A) to be earned by demonstration of success in larger PM responsibility sets.

For more information,
Visit tauber.umich.edu or call 734-647-1333
Connect via email to Diana Crossley dianak@umich.edu

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Class / Instruction Mon, 21 Feb 2022 15:54:30 -0500 2022-03-27T13:00:00-04:00 2022-03-27T16:00:00-04:00 Off Campus Location Tauber Institute for Global Operations Class / Instruction Certificate photo
BioArtography - Call for Images (March 28, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701919@events.umich.edu Event Begins: Monday, March 28, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-28T00:00:00-04:00 2022-03-28T23:59:00-04:00 BioArtography Other U-M BioArtography
Med Madness with the University of Michigan Medical School! (March 28, 2022 6:00pm) https://events.umich.edu/event/93628 93628-21706444@events.umich.edu Event Begins: Monday, March 28, 2022 6:00pm
Location:
Organized By: MAPS (Multicultural Association for Pre-health Students)

Come join us to hear from Carol Teener, the Director of Admissions at the University of Michigan Medical School! Learn all about what Michigan has to offer and get all your pre-med questions answered! This is part of MedMadness, our month-long information sessions with Medical School representatives across Michigan.

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Workshop / Seminar Fri, 18 Mar 2022 17:59:50 -0400 2022-03-28T18:00:00-04:00 2022-03-28T19:00:00-04:00 MAPS (Multicultural Association for Pre-health Students) Workshop / Seminar event flyer
BioArtography - Call for Images (March 29, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701920@events.umich.edu Event Begins: Tuesday, March 29, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-29T00:00:00-04:00 2022-03-29T23:59:00-04:00 BioArtography Other U-M BioArtography
BioArtography - Call for Images (March 30, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701921@events.umich.edu Event Begins: Wednesday, March 30, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-30T00:00:00-04:00 2022-03-30T23:59:00-04:00 BioArtography Other U-M BioArtography
DCMB / CCMB Weekly Seminar presents Rehan Akbani, PhD (Associate Professor, University of Texas, MD Anderson Cancer Center) (March 30, 2022 4:00pm) https://events.umich.edu/event/93933 93933-21711327@events.umich.edu Event Begins: Wednesday, March 30, 2022 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

The TP53 tumor suppressor gene is frequently mutated in human cancers. We illustrate the “omics” landscape of the TP53 pathway across five data platforms in 10,225 patient samples from 33 cancers reported by The Cancer Genome Atlas (TCGA). More than 91% of TP53-mutant cancers exhibit second allele loss by mutation, chromosomal deletion, or copy-neutral loss of heterozygosity. TP53 mutations are associated with enhanced chromosomal instability, including increased amplification of oncogenes and deep deletion of tumor suppressor genes. Tumors with TP53 mutations differ from their non-mutated counterparts in RNA, miRNA, and protein expression patterns, with mutant TP53 tumors displaying enhanced expression of cell cycle progression genes and proteins. A mutant TP53 RNA expression signature shows significant correlation with reduced survival in 11 cancer types. Pathway activity scores were computed for all the samples using mRNA expression levels of ten TP53 pathway member genes. Gynecologic cancers show high activity of the pathway. The pathway is correlated with immune infiltration and EMT, and anti-correlated with RTK and RAS/MAPK pathways. In particular, a strong correlation with immune infiltration is observed in breast cancer. ATAC-seq data also show high chromatin accessibility of the pathway genes in breast cancer. Thus, the TP53 pathway has profound effects on tumor cell genomic structure, expression, and clinical outlook depending on tumor type.

Short Bio
Dr. Rehan Akbani is an Associate Professor at the University of Texas MD Anderson Cancer Center in Houston, Texas, in the Department of Bioinformatics and Computational Biology. He has worked at MD Anderson since 2009. He has played many leadership roles in major enterprises, including as PI on TCGA’s MD Anderson Genome Data Analysis Center (GDAC) grant. Within the TCGA consortium, he led four of TCGA’s analysis working groups and he’s been a co-author on each one of TCGA’s 33 marker papers and 27 pan-cancer papers since 2009. His primary contributions have been leading the analysis of proteomics data, and batch effects and quality control of omics data. He won the AACR “Team Science Award” in 2020 for his work in TCGA. He was conferred the “Highly Cited Researchers 2019” award by Web of Science for co-authoring the most highly cited papers in the past decade. He has over 87,700 citations and an h-index of 78 on Google Scholar. In 2014, he won the “Test of Time” award from the European Conference on Machine Learning (ECML) for publishing the most highly cited paper in ECML a decade ago. Currently, Dr. Akbani is the Co-Director of MD Anderson’s proteomics core and Co-Director of the metabolomics core, where he’s led the development of software pipelines for normalizing raw data and generating customer reports semi-automatically. He’s also contributed proteomics data analysis for projects including the Cancer Cell Line Encyclopedia (CCLE) and the MD Anderson Cell Line Project (MCLP).

Host: Veera Baladandayuthapani, Ph.D.
https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Lecture / Discussion Thu, 24 Mar 2022 12:32:18 -0400 2022-03-30T16:00:00-04:00 2022-03-30T17:00:00-04:00 Off Campus Location DCMB Seminar Series Lecture / Discussion Rehan Akbani, PhD (Associate Professor, University of TX MD Anderson Cancer Center)
BioArtography - Call for Images (March 31, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701922@events.umich.edu Event Begins: Thursday, March 31, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-03-31T00:00:00-04:00 2022-03-31T23:59:00-04:00 BioArtography Other U-M BioArtography
“Bioengineered Synthetic Hydrogels for Regenerative Medicine" (March 31, 2022 12:00pm) https://events.umich.edu/event/92752 92752-21695194@events.umich.edu Event Begins: Thursday, March 31, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

Andrés J. García is the Executive Director of the Petit Institute for Bioengineering and Bioscience and Regents’ Professor at the Georgia Institute of Technology. Dr. García’s research program integrates innovative engineering, materials science, and cell biology concepts and technologies to create cell-instructive biomaterials for regenerative medicine and generate new knowledge in mechanobiology. This cross-disciplinary effort has resulted in new biomaterial platforms that elicit targeted cellular responses and tissue repair in various biomedical applications, innovative technologies to study and exploit cell adhesive interactions, and new mechanistic insights into the interplay of mechanics and cell biology.

In addition, his research has generated intellectual property and licensing agreements with start-up and multi-national companies. He is a co-founder of 3 start-up companies (CellectCell, CorAmi Therapeutics, iTolerance). He has received several distinctions, including the NSF CAREER Award, Young Investigator Award from the Society for Biomaterials, Georgia Tech’s Outstanding Interdisciplinary Activities Award, the Clemson Award for Basic Science from the Society for Biomaterials, the International Award from the European Society for Biomaterials, and Georgia Tech’s Class of 1934 Distinguished Professor Award.

He is an elected Fellow of Biomaterials Science and Engineering (by the International Union of Societies of Biomaterials Science and Engineering), Fellow of the American Association for the Advancement of Science, Fellow of the American Society of Mechanical Engineers, and Fellow of the American Institute for Medical and Biological Engineering. He served as President for the Society for Biomaterials in 2018-2019. He is an elected member of the National Academy of Engineering, the National Academy of Medicine, and the National Academy of Inventors.

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Lecture / Discussion Fri, 18 Mar 2022 10:06:32 -0400 2022-03-31T12:00:00-04:00 2022-03-31T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Lecture / Discussion Andrés J. García, Ph.D.
DCM&B Tools and Technology Seminar (March 31, 2022 12:00pm) https://events.umich.edu/event/89812 89812-21665890@events.umich.edu Event Begins: Thursday, March 31, 2022 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

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Presentation Thu, 27 Jan 2022 12:48:19 -0500 2022-03-31T12:00:00-04:00 2022-03-31T13:00:00-04:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
Strategies for finding genes in time-dependent human phenotypes: The genetics of delta-t (March 31, 2022 3:30pm) https://events.umich.edu/event/93968 93968-21712968@events.umich.edu Event Begins: Thursday, March 31, 2022 3:30pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: Biomedical Engineering

Abstract:
Each person's physiology (phenotype) changes over their lives. While there are common patterns in these changes as we age, there are also significant differences between individuals. Differences in phenotype are dependent on the interaction of the individual's environment and their unique genetic makeup (genotype). What are the genes -- and variants in these genes -- in the human population that impact the variation we see in time-dependent phenotypes? The talk will address the challenges of studying the complexity of human age- and time-dependent (longitudinal) phenotypes. TIme-dependent experimental strategies will require new types of reproducible, non-invasive, quantitative phenotype measurement tools. And, to have a general impact, human measurement technologies should be broadly accessible, particularly to under-served populations. A low-cost, quantitative system for measuring neurological status will be presented as an initial prototype for non-invasive longitudinal phenotype assessment.
Bio:
Dr. Burke is a Professor in the Department of Human Genetics, University of Michigan Medical School. His research centers on developing experimental strategies and technologies for exploring complex, multi-gene genetics in humans. Dr. Burke is interested in understanding the interaction of genetic variation and the environment with chronic, late-life diseases. Before joining the University of Michigan in 1991, he was a post-doctoral fellow in molecular genetics at Princeton University where he studied the laboratory mouse as a model genetic system. Dr. Burke obtained his PhD in the Department of Genetics at Washington University in St. Louis, where he was working on the initial stages of the Human Genome Project. During his time at Michigan, he has worked collaboratively with research groups in the UM College of Engineering, primarily in the area of microfluidics.

Zoom Link: https://umich.zoom.us/j/96508834308

Organized by:
Dr. Brendon Baker,
Assistant Professor, Biomedical Engineering

Dr. David Nordsletten,
Associate Professor, Department of Biomedical Engineering and Cardiac Surgery

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Workshop / Seminar Fri, 25 Mar 2022 08:58:52 -0400 2022-03-31T15:30:00-04:00 2022-03-31T16:30:00-04:00 Lurie Biomedical Engineering (formerly ATL) Biomedical Engineering Workshop / Seminar BME Seminar
BioArtography - Call for Images (April 1, 2022 12:00am) https://events.umich.edu/event/73295 73295-21701923@events.umich.edu Event Begins: Friday, April 1, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-01T00:00:00-04:00 2022-04-01T23:59:00-04:00 BioArtography Other U-M BioArtography
April in Paris: Life Sciences Orchestra concert (April 1, 2022 7:30pm) https://events.umich.edu/event/93022 93022-21699125@events.umich.edu Event Begins: Friday, April 1, 2022 7:30pm
Location: Hill Auditorium
Organized By: Life Sciences Orchestra

The LSO returns to the stage after two years with a free concert that includes three works with a French connection, and a piano concerto by the first Black American female composer to have her work performed by major symphony orchestras.

The program includes:
Mozart's Symphony No. 31, known as the Paris Symphony
Florence Price's Piano Concerto in One Movement, featuring Xiaoya Liu
Debussy's La Mer (first movement)
Berlioz's Symphonie Fantastique (first movement)

The LSO's music director is Yeo Ryeong Ahn, assisted by Leonard Bopp. Both are students in orchestral conducting at the U-M School of Music, Theatre & Dance; Ahn recently competed in the international La Maestra competition for female conductors in Paris.

The orchestra is made up of faculty, staff, students, alumni and volunteers from the U-M medical, health and science community, and is a program of Gifts of Art at Michigan Medicine.

The concert is free and no tickets are required. Audience members must complete the Responsiblue guest screening at https://bit.ly/LSOguest and wear a mask at all times, and no children under 3 will be admitted. Any other COVID protocols required for the concert will be posted by the week of the concert on the LSO website and Facebook page

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Performance Mon, 28 Mar 2022 08:25:01 -0400 2022-04-01T19:30:00-04:00 2022-04-01T21:15:00-04:00 Hill Auditorium Life Sciences Orchestra Performance Composer Florence Price is the centerpiece of the LSO concert poster
BioArtography - Call for Images (April 2, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742264@events.umich.edu Event Begins: Saturday, April 2, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-02T00:00:00-04:00 2022-04-02T23:59:00-04:00 BioArtography Other U-M BioArtography
BioArtography - Call for Images (April 3, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742265@events.umich.edu Event Begins: Sunday, April 3, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-03T00:00:00-04:00 2022-04-03T23:59:00-04:00 BioArtography Other U-M BioArtography
BioArtography - Call for Images (April 4, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742266@events.umich.edu Event Begins: Monday, April 4, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

]]>
Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-04T00:00:00-04:00 2022-04-04T23:59:00-04:00 BioArtography Other U-M BioArtography
Isa Kujawski - Health & Wellness, Food, Digestion, Psychology (April 4, 2022 6:00pm) https://events.umich.edu/event/93234 93234-21701671@events.umich.edu Event Begins: Monday, April 4, 2022 6:00pm
Location: Off Campus Location
Organized By: Bio-Tech, Entrepreneurship, and Coding Organization

On Monday, April 04, 2022 @ 6:00PM-7:00PM ET, come virtually listen to alumni Isa Kujawksi discuss the interconnections between mental, metabolic, and nutritional health; integrative medicine; the day-to-day in a nutritional counseling role; her podcast and start-up Mea Nutrition; and case studies from military retirees, first responders, PTSD/depression/anxiety patients and their nutritional therapy plans.

Please feel free to distribute the following event flyer: https://drive.google.com/file/d/1WbE_I83i-KFNWQpGWDysOVShZixW3TQ4/view.

This event is co-hosted by three student organizations: kinesiology-focused Phi Epsilon Kappa ("PEK"), business-focused Bio-Tech, Entrepreneurship, and Coding Organization ("BECO"), and engineering-focused Food Industry Student Association ("FISA"). Please navigate to PEK's, BECO's, and FISA's respective homepages linked on this post to learn more and join their email lists.

All members of the UofM community (students, faculty, staff, alumni, etc.) are welcome! Please sign in to view the Zoom link. No pressure to participate, turn on cameras, or unmute! Hope to see you there!

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Workshop / Seminar Sun, 03 Apr 2022 12:11:51 -0400 2022-04-04T18:00:00-04:00 2022-04-04T19:00:00-04:00 Off Campus Location Bio-Tech, Entrepreneurship, and Coding Organization Workshop / Seminar Mental and Nutritional Health
BioArtography - Call for Images (April 5, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742267@events.umich.edu Event Begins: Tuesday, April 5, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-05T00:00:00-04:00 2022-04-05T23:59:00-04:00 BioArtography Other U-M BioArtography
Health Professions Education Day 2022 (April 5, 2022 8:30am) https://events.umich.edu/event/90786 90786-21673925@events.umich.edu Event Begins: Tuesday, April 5, 2022 8:30am
Location: Michigan League
Organized By: Department of Learning Health Sciences

Health Professions Education Day is an annual event that brings together faculty, students, and staff from the 10 health science schools across the University of Michigan’s three campuses to share best practices for interprofessional education and collaborative care.

Many of our educators work collaboratively through the U-M Center for Interprofessional Education (C-IPE) to develop and teach novel courses and collaborative care opportunities focused on interprofessional health education.

This annual event aims to spark interprofessional collaboration, networking, and inspiration for future research and practice for educational efforts across the health professions schools at the University of Michigan.

Abstracts are currently being accepted until 11:59 PM ET on Tuesday, February 1, 2022. Registration is open now.

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Conference / Symposium Wed, 12 Jan 2022 08:48:24 -0500 2022-04-05T08:30:00-04:00 2022-04-05T12:30:00-04:00 Michigan League Department of Learning Health Sciences Conference / Symposium Health Professions Education Day
BioArtography - Call for Images (April 6, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742268@events.umich.edu Event Begins: Wednesday, April 6, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-06T00:00:00-04:00 2022-04-06T23:59:00-04:00 BioArtography Other U-M BioArtography
Immunotherapeutic and Diagnostic Potential of Engineered Materials (April 6, 2022 2:00pm) https://events.umich.edu/event/94118 94118-21722028@events.umich.edu Event Begins: Wednesday, April 6, 2022 2:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Globally, breast cancer has the highest rates of incidence and mortality among women. For breast cancer diagnoses, while there is a 99% five-year relative survival rate for localized disease, survival drops to 29% for progression to metastatic disease. And, although robust advances have been made in the treatment of localized breast cancer, few therapies exist to effectively treat metastases. As such, distant spread marks the disease stage where treatment no longer has curative intent, and disease progression leads to mortality. The increased mortality with metastasis motivates the development of diagnostic and therapeutic strategies for managing metastatic disease, and I hypothesize that the microenvironment at the metastatic niche can serve as a target for these strategies.

First, I present a study investigating the utility of cargo-free PLGA nanoparticles (NPs) that, upon intravenous delivery, can be internalized by myeloid cells and subsequently alter their impact on the metastatic niche. We demonstrated that NPs reduce metastatic colonization of the lungs in a murine model of metastatic triple negative breast cancer (mTNBC). The NPs were found to modulate the immune microenvironment of the lungs, skewing myeloid cells toward inflammatory, anti-tumor phenotypes through single cell RNA sequencing. We then found that the reduction of metastatic spread was dependent on mature T-cells. Finally, NPs were administered in a primary tumor (PT) resection model and shown to lead to clearance of established metastatic lesions when delivered as an adjuvant therapy, following surgical resection.

The treatment of TNBC with immune checkpoint blockade (ICB) therapy, a T-cell targeted immunotherapy, has shown robust improvements in patient outcomes. However, while ICB-sensitive patients have durable responses to therapy, no effective biomarkers are available for predicting ICB-response and stratifying ICB-sensitivity from ICB-resistance. Our lab has previously shown that the immune milieu of a microporous PCL implant, which recapitulates key features of the native metastatic niche, can be longitudinally probed for monitoring 1) progression of cancer and 2) response to a PT resection. I investigate the hypothesis that the microporous implant can be longitudinally probed for ICB-response. Divergent responses in TNBC progression, as a result of anti-PD-1 administration, were identified and gene expression at the implant allowed for the ability to monitor ICB-response. Differential lymphocyte and myeloid cell responses were also identified that are correlative of the divergent responses to therapy. Finally, implant-derived gene expressions were probed prior to treatment to investigate predictive analytes for ICB-response before initiating therapy.

Overall, this dissertation demonstrates the potential for applying engineered materials to 1) modulate cancer-associated myeloid cells to enhance anti-tumor T-cell surveillance with the goal of clearing metastatic disease and 2) probe biomarkers to stratify ICB-response and investigate mechanisms underlying therapy resistance.

Date: Wednesday, April 6, 2022
Time: 2:00 PM EST
Zoom: https://umich.zoom.us/j/94478502873
Chair: Professor Lonnie D. Shea

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Presentation Tue, 29 Mar 2022 13:19:30 -0400 2022-04-06T14:00:00-04:00 2022-04-06T15:00:00-04:00 Off Campus Location Biomedical Engineering Presentation BME Ph.D. Defense
BioArtography - Call for Images (April 7, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742269@events.umich.edu Event Begins: Thursday, April 7, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-07T00:00:00-04:00 2022-04-07T23:59:00-04:00 BioArtography Other U-M BioArtography
DCM&B Tools and Technology Seminar (April 7, 2022 12:00pm) https://events.umich.edu/event/89813 89813-21665891@events.umich.edu Event Begins: Thursday, April 7, 2022 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

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Presentation Tue, 07 Dec 2021 09:11:01 -0500 2022-04-07T12:00:00-04:00 2022-04-07T13:00:00-04:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
Dynamical network models of the epileptic brain to improve surgical outcomes (April 7, 2022 3:30pm) https://events.umich.edu/event/94203 94203-21724114@events.umich.edu Event Begins: Thursday, April 7, 2022 3:30pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: Biomedical Engineering

Abstract:

Medically-refractory epilepsy (MRE) is a devastating neurological disease that is defined by recurrent and unprovoked seizures that are insufficiently controlled by anti-epileptic medication. If the seizures are originating from a specific region of the brain, surgical removal or stimulation of the epileptogenic region can be an effective therapy for these patients. The accurate localization of the seizure onset zone (SOZ) is critical for surgical success, but localizing the SOZ often requires implantation of intracranial EEG electrodes and continuous monitoring in the hospital for days to weeks so that seizures are recorded. Despite the longevity and invasiveness of this procedure, surgical success rates can be as low as 34%. In this talk, I will describe a study that aims to improve seizure onset localization and expedite the intracranial monitoring process by employing dynamical network models that investigate the patient’s epileptogenic network with recordings obtained during single-pulse electrical stimulation (SPES). We hypothesize that a dynamical quantification of the connectivity networks derived from the evoked responses induced by SPES could also be used to accurately localize the SOZ and guide clinicians in eliciting native seizures with electrical stimulation. I will give an overview of these dynamical network techniques and describe their potential impact in the clinical treatment of medically-refractory epilepsy.

Bio:

Rachel June Smith is a postdoctoral fellow in the Biomedical Engineering Department and Institute for Computational Medicine at Johns Hopkins University. She received her B.S. in Biomedical Engineering from the University of Tennessee, Knoxville, in 2014 and her M.S. and Ph.D. from UC Irvine in Biomedical Engineering in 2019. Her doctoral work focused on the development of computational metrics in scalp EEG data that reflected disease burden and predicted response to treatment in patients with infantile spasms. Currently, Rachel uses dynamical systems and control theory techniques to localize the onset of seizures in the epileptic brain. Rachel has been recently recognized for her work by the American Epilepsy Society where she won a 2020 Young Investigator Award and was named an AES Fellow.

Zoom Link: https://umich.zoom.us/j/96508834308

Organized by:

Dr. Brendon Baker,
Assistant Professor, Biomedical Engineering

Dr. David Nordsletten,
Associate Professor, Department of Biomedical Engineering and Cardiac Surgery

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Workshop / Seminar Wed, 30 Mar 2022 15:27:55 -0400 2022-04-07T15:30:00-04:00 2022-04-07T16:30:00-04:00 Lurie Biomedical Engineering (formerly ATL) Biomedical Engineering Workshop / Seminar BME 500 Seminar
BioArtography - Call for Images (April 8, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742270@events.umich.edu Event Begins: Friday, April 8, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-08T00:00:00-04:00 2022-04-08T23:59:00-04:00 BioArtography Other U-M BioArtography
BioArtography - Call for Images (April 9, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742271@events.umich.edu Event Begins: Saturday, April 9, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-09T00:00:00-04:00 2022-04-09T23:59:00-04:00 BioArtography Other U-M BioArtography
BioArtography - Call for Images (April 10, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742272@events.umich.edu Event Begins: Sunday, April 10, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-10T00:00:00-04:00 2022-04-10T23:59:00-04:00 BioArtography Other U-M BioArtography
Project Management Certification (April 10, 2022 1:00pm) https://events.umich.edu/event/91083 91083-21677008@events.umich.edu Event Begins: Sunday, April 10, 2022 1:00pm
Location: Off Campus Location
Organized By: Tauber Institute for Global Operations

Once again, the Tauber Institute, in conjunction with the International Project Management Association (IPMA), is sponsoring a Project Management certification class and exam for graduate business and engineering students, alumni, and staff.

In order to participate, you will need to reflect upon a project management experience (for example: a work project, an engineering design experience/senior capstone, Ross' MAP project, Tauber team project, etc). If you cannot make it to the classes (due to project travel, MAP, or other another class), the sessions will be recorded. Homework (mastery verification) will be required after each session.

The cost to an individual to take the exam is normally $595, however, Tauber is offering the exam at a substantial discount to non-Tauber students:
$550 for U-M alumni or public
$425 for U-M students, U-M employees, or Tauber alumni
$325 for U-M Ross School of Business or U-M College of Engineering staff
$225 for Tauber Institute students
$145 for previous students to retake the exam

Certification is valid for 5 years. Three certification classes will be taught by Professor Eric Svaan on the following dates:

Sunday, March 13 (1:00 pm - 4:00 pm)
Sunday, March 27 (1:00 pm - 4:00 pm)
Sunday, April 10 (1:00 pm - 4:00 pm)

The certification exam, administered by IPMA-USA is scheduled for May 1, 2022 (11:00 am) virtually. Successfully passing the exam will yield IPMA's Level D certification (Certified Project Management Associate).

Project Management is a powerful skill set to have in your toolbox as you look for full-time employment!

REGISTRATION: Please register through iMpact by clicking here:
https://www.bus.umich.edu/Conferences/Project-Management-Certification-2022/Default.aspx

NOTE: The non-refundable fees

HOSTED BY: Tauber Institute for Global Operations. For questions about this event, please contact tauberinstitute@umich.edu or visit tauber.umich.edu.

What is IPMA Level D® (Certified Project Management Associate)? The IPMA Level D is an internationally recognized entry-level qualification in the area of project management. This designation, which demonstrates the individual's ability to understand the basics of project management, is similar to the exam-oriented, knowledge-based certifications of other major Project Management associations. For many, Level D® is the first step towards a professional project or program manager role. It is the first step in a sequence (C, B and A) to be earned by demonstration of success in larger PM responsibility sets.

For more information,
Visit tauber.umich.edu or call 734-647-1333
Connect via email to Diana Crossley dianak@umich.edu

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Class / Instruction Mon, 21 Feb 2022 15:54:30 -0500 2022-04-10T13:00:00-04:00 2022-04-10T16:00:00-04:00 Off Campus Location Tauber Institute for Global Operations Class / Instruction Certificate photo
BioArtography - Call for Images (April 11, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742273@events.umich.edu Event Begins: Monday, April 11, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-11T00:00:00-04:00 2022-04-11T23:59:00-04:00 BioArtography Other U-M BioArtography
BioArtography - Call for Images (April 12, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742274@events.umich.edu Event Begins: Tuesday, April 12, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-12T00:00:00-04:00 2022-04-12T23:59:00-04:00 BioArtography Other U-M BioArtography
2022 Institute for Healthcare Policy & Innovation Director’s Lecture: A Conversation with Dr. Joneigh Khaldun (April 12, 2022 3:00pm) https://events.umich.edu/event/94176 94176-21723578@events.umich.edu Event Begins: Tuesday, April 12, 2022 3:00pm
Location: North Campus Research Complex Building 10
Organized By: Institute for Healthcare Policy and Innovation

Join IHPI Director Dr. John Ayanian and Dr. Joneigh Khaldun as they discuss the challenges of mobilizing public health responses to COVID-19 in the face of profound disparities.

In-person attendance is available for members of the U-M Community. Reception to follow from 4:00-4:30 pm.

Registration is required for both in-person and live-streaming attendance.

All in-person attendees will be required to complete the ResponsiBLUE health screening for entrance and adhere to U-M face-covering policies at the time of the event.

#IHPI22

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Lecture / Discussion Wed, 30 Mar 2022 10:19:39 -0400 2022-04-12T15:00:00-04:00 2022-04-12T16:00:00-04:00 North Campus Research Complex Building 10 Institute for Healthcare Policy and Innovation Lecture / Discussion Dr. Joneigh Khaldun
BioArtography - Call for Images (April 13, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742275@events.umich.edu Event Begins: Wednesday, April 13, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-13T00:00:00-04:00 2022-04-13T23:59:00-04:00 BioArtography Other U-M BioArtography
The Art of Emotional Intelligence (April 13, 2022 6:00pm) https://events.umich.edu/event/87836 87836-21647061@events.umich.edu Event Begins: Wednesday, April 13, 2022 6:00pm
Location: Off Campus Location
Organized By: Michigan Medicine Wellness Office

Emotional intelligence can help with our personal relationships, but can also strengthen our professional communication and ability to perform at school/work.

Register to receive zoom link: https://sessions.studentlife.umich.edu/track/event/session/45700

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Well-being Mon, 04 Oct 2021 11:49:23 -0400 2022-04-13T18:00:00-04:00 2022-04-13T19:00:00-04:00 Off Campus Location Michigan Medicine Wellness Office Well-being Wellness Office Logo
U-M Addiction Center Community Education Series (April 13, 2022 7:00pm) https://events.umich.edu/event/91805 91805-21683056@events.umich.edu Event Begins: Wednesday, April 13, 2022 7:00pm
Location: Off Campus Location
Organized By: UM Addiction Center

The U-M Addiction Center is hosting a free, virtual community education series designed for individuals and families. Join experts from U-M Addiction Treatment Services (UMATS), live via Zoom to learn more about important topics related to addiction and recovery.

This third session of the 4-part series, will take place on April 13th, 2022 from 7pm-8pm via Zoom. Participants will learn about the various medications that can be used to treat substance use disorders and how they're used as part of a successful program of recovery. Resources on how to obtain help and support will be provided.

Registered attendees will receive a reminder email from zoom the day before and the morning of.

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Livestream / Virtual Tue, 01 Feb 2022 08:56:09 -0500 2022-04-13T19:00:00-04:00 2022-04-13T20:00:00-04:00 Off Campus Location UM Addiction Center Livestream / Virtual Click on the link below to register.
BioArtography - Call for Images (April 14, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742276@events.umich.edu Event Begins: Thursday, April 14, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-14T00:00:00-04:00 2022-04-14T23:59:00-04:00 BioArtography Other U-M BioArtography
Cellular Mechanisms of Lip and Primary Palate Fusion (April 14, 2022 12:00pm) https://events.umich.edu/event/94366 94366-21735840@events.umich.edu Event Begins: Thursday, April 14, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

A. Personal Statement

Highlighted publications:

Lewis A.E., Kuwahara A., Franzosi J., Bush, J.O.* (2022) Tracheal separation is driven by NKX2-1-mediated repression of Efnb2 and regulation of endodermal cell sorting. Cell Reports, 38(11):110510

Kindberg A.A., Srivastava, V., Muncie, J.M., Weaver V.M., Gartner, Z.J. and Bush, J.O.* (2021). EPH/EPHRIN regulates cellular organization by actomyosin contractility effects on cell contacts Journal of Cell Biology 220 (6): e202005216 PMCID: PMC8025214

Kuwahara, A., Lewis, A., Coombes, C., Leung, F.S., Percharde M., Bush J.O.* (2020) Delineating the early transcriptional specification of the mammalian trachea and esophagus. eLife, 9:e55526 PMCID: PMC7282815

Niethamer, T. K., Teng, T., Franco, M., Du, Y. X., Percival, C. J., Bush, J.O.* (2020). Aberrant cell segregation in the craniofacial primordium and the emergence of facial dysmorphology in craniofrontonasal syndrome. PLoS Genet. 16, e1008300.

Highlighted projects:
R35 DE031926-01 (PI: Bush) 4/1/2022-3/31/2030
NIH/NIDCR
Signaling control and cellular basis of craniofacial morphogenesis and congenital disease

R01 DE023337 (PI: Bush) 7/9/2013-3/31/2022
NIH/NIDCR
Mechanisms of Eph/Ephrin signaling in craniofacial morphogenesis and craniofrontonasal syndrome

R01DE028753 (PI: Selleri) 4/1/2019-3/31/2024
NIH/NIDCR
Phenotype-driven approach to understanding the function of craniofacial regulators using IMPC-generated mouse strains

UG3DE028872 (PI: Klein) 7/1/2019-6/30/2024
NIH/NIDCR
“Enamel atlas: systems-level amelogenesis tools at multiple scales”

B. Positions, Scientific Appointments and Honors
Positions and Employment:
2019-present Vice Chair, Department of Cell and Tissue Biology
2021-present Professor, Department of Cell and Tissue Biology and Program in Craniofacial Biology, University of California at San Francisco
2017-2021 Associate Professor, Department of Cell and Tissue Biology and Program in Craniofacial
Biology, University of California at San Francisco
2011-2017 Assistant Professor, Department of Cell and Tissue Biology and Program in
Craniofacial Biology, University of California at San Francisco
2005-2011 Postdoctoral research at FHCRC/MSSM
Advisor: Dr. Philippe Soriano
1999-2005 Graduate and postdoctoral research at University of Rochester
Advisor: Dr. Rulang Jiang

Awards and Honors:
2021 Marylou Buyse Distinguished Scientist in Craniofacial Research award from the Society for Craniofacial Genetics and Developmental Biology
2019 F1000 Faculty member for Developmental Biology
2019 David W. Smith workshop on malformations and morphogenesis keynote
2014 American Association of Anatomists Young Faculty Travel Award
2010-present F1000/F1000Prime has featured and highly ranked five of our publications
2010 NIH pathway to independence award from NIH/NIDCR K99/R00 (DE020855)
2006-2008 Ruth L Kirschstein NRSA Individual Fellowship from NIH/NIDCR F32 (DE17506)
2005 Basil Bibby award from the AADR
2004 Michael G. Buonocore award from the AADR

Other Experience and Professional Memberships
2021-2025 Member NIH Skeletal Biology Development and Disease (SBDD)
2021 Cold Spring Harbor Labs Mouse Engineering Course lecturer and workshop leader
2021 American Association of Anatomists Program Committee
2020 Ad hoc reviewer NIH/NIDCR SEP ZDE1 Endogenous Regeneration of Dental, Oral and Craniofacial Tissue
2020 Ad hoc reviewer NIH CSR ZRG1 Fellowships: Cell Biology, Developmental Biology and Bioengineering
2020 Ad hoc reviewer Czech Science Foundation
2019 Ad hoc reviewer for NIH Skeletal Biology Development and Disease (SBDD)
2017 Ad hoc reviewer for NIH on Microphysiological Systems (MPS) for Disease Modeling and Efficacy Testing (UG3/UH3) “Tissue Chips and Disease Modeling”
2017-present International Association for Dental Research
2017 Guest Editor, Developmental Biology, special issue on signaling in development
2014 Ad hoc reviewer for NIH on SEP ZRG1 MOSS-D (02), “Bone, Cartilage and Tendon”
2013, 2014 Invited peer reviewer for UK MRC
2012 Ad hoc reviewer for NIH on Council ZES1, “Environmental influences on stem cells in development, health and disease”
2012 Organizer, session chair, Society of Craniofacial Genetics Annual Meeting, San Francisco, CA
2012-present Member, Society for Craniofacial Genetics and Development
2010-present Member, American Association of Anatomists
2000-present Member, Society for Developmental Biology
Ad hoc Reviewer for Development, Developmental Biology, Developmental Dynamics, Journal of Dental Research, Genesis, Immunobiology, Journal of Cell Biology, Science, PLOS Genetics, Immunobiology, PLOS One, Developmental Cell, PLOS Biology, Human Molecular Genetics, JOVE

C. Contributions to Science
1. Identified Eph/ephrin cellular mechanisms in morphogenesis
We have made major contributions to understanding EPH/EPHRIN signaling mechanisms in development in multiple contexts including the craniofacial, neural and neural crest systems. The EPHs compose the largest family of receptor tyrosine kinases in the vertebrate genome constituting one quarter of the total number. Though extensively studied in the nervous system, the signaling mechanisms utilized by this family in other contexts are complex and modestly understood, particularly in vivo. We have learned that a large number of these molecules exhibit distinct expression patterns in the developing craniofacial region. In a novel “conditional-rescue” approach we discovered that EPHRIN-B2 is required in the vascular endothelium for normal NCC development. EPH/EPHRIN signaling is widely known to regulate cellular organization, but the signaling mechanisms by which it does so are unclear. By studying a series of targeted and signaling mutations in EPHRIN-B1 and its receptors EPHB2 and EPHB3 in mice, we determined that EPH/EPHRIN cell segregation involves unidirectional forward signaling from EPHRIN-B1 and relies on kinase activity of the receptors. By live cell imaging we also observe that this unidirectional signaling results in changes in cortical actomyosin accumulation and leading us to interrogate the biophysical basis for EPH/EPHRIN cell segregation. We recently discovered that EPH/EPHRIN signaling modulates the strength of cell-cell contacts by regulating cell interfacial tension through increased heterotypic cortical actomyosin contractility. The minimization of heterotypic interfacial tension also informs how EPH/EPHRIN signaling regulates tissue shape changes relevant to Contributions number 2 and 4. Current efforts in this area focus on how EPH/EPHRIN signaling regulates mesenchymal cell polarity and cell position, forming the basis for part of “Focus one” of this proposal.

Agrawal, P., Wang, M., Kim, S., Lewis, A.E., Bush, J.O.* (2014) The embryonic expression of EphA receptor genes in mice supports their candidacy for involvement in cleft lip and palate. Developmental Dynamics, 243 (11): 1470-6. PMCID: PMC4404412
Lewis, A.E., Hwa, J., Wang, R., Soriano P., Bush, J.O.* (2015) Neural crest defects in ephrin-B2 mutant mice are non-autonomous and originate from defects in the vasculature. Developmental Biology, 406(2): 186-95. PMCID: PMC4639416
O’Neill, A.O., Kindberg, A.A., Niethamer, T.K. Larson, A.R., Ho, H.H., Greenberg, M.E., Bush, J.O.* (2016) Unidirectional Eph/ephrin signaling creates a cortical actomyosin differential to drive cell segregation. Journal of Cell Biology, 215 (2): 217 PMCID: PMC5984648
Kindberg A.A., Srivastava, V., Muncie, J.M., Weaver V.M., Gartner, Z.J. and Bush, J.O.* (2021). EPH/EPHRIN regulates cellular organization by actomyosin contractility effects on cell contacts Journal of Cell Biology 220 (6): e202005216 PMCID: PMC8025214

2. Delineated Eph/ephrin signaling mechanisms underlying craniofrontonasal syndrome
We have focused on the role of EPH/EPHRIN signaling in craniofrontonasal syndrome (CFNS), an X-linked condition caused by mutations in EFNB1 characterized by hypertelorism, craniosynostosis, cleft lip and palate, agenesis of the corpus callosum, and particularly increased severity in female patients. By generating a series of signaling mutations in three different gene targeted mouse lines, we were able to determine the relevant modes of signaling for different EPHRIN-B1 phenotypes. We found that reverse signaling by a PDZ-dependent mechanism is critical for axon guidance, whereas it is dispensible for skeletal and craniofacial development. This work showed that different aspects of craniofrontonasal syndrome are caused by loss of function of distinct molecular EPHRIN-B1 signaling functions. Further, by integrating mouse genetics, phosphoproteomic and transcriptomic approaches we have investigated downstream signaling pathways utilized by EPHRIN-B1 in craniofacial development and disease. In this context, we were the first to show that EPH receptor expression is regulated by endocytosis in vivo, and that EPHRIN-B1 controls cell proliferation by the Ras/MAPK signaling pathway. We have also generated an hiPSC model for CFNS, which to our knowledge is the first hiPSC model of a congenital craniofacial syndrome, and used to it ask key questions about the cellular etiology underlying this perplexing disease. Recently, we coupled geometric morphometric techniques with temporal and spatial manipulation of EPHRIN-B1 signaling to elucidate how Efnb1 mutations result in stereotyped dysmorphology in CFNS. Current efforts in this area focus on delineating the proximal signal transduction mechanisms employed by EPH/EPHRIN-B1 signaling in craniofacial morphogenesis using CRISPR/CAS9 based methods.

Bush, J. O. and Soriano, P. (2010). Ephrin-B1 forward signaling regulates craniofacial morphogenesis by controlling cell proliferation across Eph-ephrin boundaries. Genes Dev. 24, 2048-60. PMCID: PMC2939368
Niethamer, T.K., Larson, A.R., O’Neill A.K., Bershteyn, M., Hsiao, E.C., Klein, O.D., Pomerantz, J.H., Bush J.O.* (2017) EPHRIN-B1 mosaicism drives cell segregation in craniofrontonasal syndrome hiPSC-derived neuroepithelial cells. Stem Cell Reports, 8(3): 529-537. PMCID: PMC5355632
Niethamer, T. K. and Bush, J. O.* (2019). Getting direction(s): The Eph/ephrin signaling system in cell positioning. Dev. Biol. 447, 42–57.
Niethamer, T. K., Teng, T., Franco, M., Du, Y. X., Percival, C. J., Bush, J. O. (2020). Aberrant cell segregation in the craniofacial primordium and the emergence of facial dysmorphology in craniofrontonasal syndrome. PLoS Genet. 16, e1008300.

3. Developed live imaging approaches to discover cellular mechanisms of craniofacial tissue fusions
Though tissue fusion is a critical final step of lip and palate development, we currently lack cellular resolution understanding of how these tissue fusion events occur, and how they are controlled. We have been examining the cellular and molecular mechanisms by which tissue fusion occurs by combining live imaging of mouse morphogenesis with mouse genetic and physical perturbations. We developed the first successful application of confocal live imaging technology to secondary palate development, and it has allowed us to make new discoveries on the cellular mechanisms at play. Our results indicate that tissue fusion proceeds by a progression of dynamic cell behaviors beginning with convergence of two independent epithelia and concomitant to orthogonal displacement of the resultant shared epithelium. Further, we have found that epithelial cell extrusion, in which cells are squeezed out of an epithelium, is a novel contributor to the removal of the midline epithelial seam (MES). A nearly completed manuscript presents a new live imaging approach to understanding secondary palate fusion, and demonstrates a unique and novel form of collective epithelial migration that is crucial for this process. Most recently, we have also established live imaging approaches for the study of upper lip/primary palate fusion, which we are using to study roles for actomyosin contractility and cell adhesion in this process.

Bush J.O.*, Jiang R.* (2012) Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development. Development. 139(2):231-43. PMCID: PMC3243091
Kim, S., Lewis A.E., Singh V., Ma, X., Adelstein, R., Bush, J.O.,* (2015) Convergence and extrusion are required for normal fusion of the mammalian secondary palate. PLOS Biology, 13(4) PMCID: 4388528
Kim S., Prochazka, J., Bush J.O.*, (2017) Live imaging of Mouse Secondary Palate Fusion. JoVE. July 2017 (125) PMCID: In process

4. Improved mouse genetics tools for the study of craniofacial and neural crest development and disease
In the course of our studies, we discovered that the Wnt1-Cre mouse line exhibits developmental phenotypes attributable to elevated and ectopic activation of Wnt signaling. This is a standard and widely used reagent in the fields of craniofacial development and neural crest stem cell biology and our careful analysis of this reagent has already had broad-reaching effects causing labs to re-examine previously published work. To provide a reagent that is devoid of these complications, we generated a Wnt1-Cre2 transgenic mouse line that exhibits the same pattern of activity as Wnt1-Cre but does not cause ectopic activation of Wnt signaling or developmental phenotypes. Over the past five years, I have also served as the faculty advisor for the UCSF mouse inventory database, which facilitates the sharing of genetically modified mouse lines. Most recently, my lab has successfully adopted the iGONAD electroporation method for rapid generation of new mouse lines which we are employing to generate new mouse models for the study of congenital disease.

Lewis, A., Vasudevan, H., O’Neill, A., Soriano, P., Bush, J.O.* (2013) The widely used Wnt1-Cre transgene causes developmental phenotypes by ectopic activation of Wnt signaling. Developmental Biology, 379(2):229-34. PMCID: PMC3804302
Wall, E., Scoles, J., Joo, A., Klein, O., Quinonez, C., Bush, J. O., Martin, G. R. and Laird, D. J. (2020). The UCSF Mouse Inventory Database Application, an Open-Source Web App for Sharing Mutant Mice within a Research Community. G3 (Bethesda).

5. Understanding how cell fate and morphogenesis are coupled in the developing foregut
Based initially on phenotypes that we discovered in an Efnb2 mutant mouse line that we generated, we have now established a robust research focus on understanding the specification and morphogenesis of the trachea and esophagus. Classical developmental biology experiments hypothesize that two transcription factors, NKX2.1 and SOX2 act as master regulators of these fates, but this remains untested at the transcriptome level and their targets were unknown. we combine state-of-the-art transcriptomic experiments in embryonic tissues with functional mouse genetic experiments to expose the fundamental process of fate specification of the trachea and esophagus. We performed single cell RNA sequencing in mice to establish a transcriptome-wide understanding of the early steps of trachea and esophagus development and used these data, combined with RNA-sequencing of mutants and embryonic ChIP-seq to interrogate the transcriptome-wide function of NKX2.1 in tracheal and esophageal development. The results of these experiments provide a new understanding of how the trachea and esophagus are initially specified at the genome-wide level. Our studies also reveal that NKX2.1 directly represses Efnb2 to regulate the site of tracheoesophageal separation. These discoveries may be impactful to the study of tracheal, lung, and esophageal developmental biology and related structural anomalies in humans, as well as for the fields of embryonic stem cell biology and for lung and esophageal cancer for which these are keystone transcriptional pathways.

Kuwahara, A., Lewis, A., Coombes, C., Leung, F.S., Percharde M., Bush J.O.* (2020) Delineating the early transcriptional specification of the mammalian trachea and esophagus. eLife, 9:e55526 PMCID: PMC7282815
Lewis A.E., Kuwahara A., Franzosi J., Bush, J.O.* (2022) Tracheal separation is driven by NKX2-1-mediated repression of Efnb2 and regulation of endodermal cell sorting. Cell Reports, 38(11):110510

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Lecture / Discussion Tue, 05 Apr 2022 10:39:07 -0400 2022-04-14T12:00:00-04:00 2022-04-14T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Lecture / Discussion Jeffrey Bush Professor and Vice Chair, Department of Cell and Tissue Biology and Program in Craniofacial Biology
DCM&B Tools and Technology Seminar (April 14, 2022 12:00pm) https://events.umich.edu/event/89814 89814-21665892@events.umich.edu Event Begins: Thursday, April 14, 2022 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

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Presentation Fri, 25 Mar 2022 10:41:08 -0400 2022-04-14T12:00:00-04:00 2022-04-14T13:00:00-04:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
Reimagining Primary Health Care for Individuals with Disabilities (April 14, 2022 2:00pm) https://events.umich.edu/event/93989 93989-21713515@events.umich.edu Event Begins: Thursday, April 14, 2022 2:00pm
Location: Off Campus Location
Organized By: Inter-university Consortium for Political and Social Research

Webinar registration link: https://umich.zoom.us/webinar/register/WN_5NqKB4IwQHaNSB4TR6baNw

Nearly 1 in 4 individuals report a disability, yet current health care is poorly equipped to care for them. Individuals with disabilities report miscommunication, inaccessible health equipment and facilities, reduced awareness and training by health care providers, and low patient satisfaction while struggling with inadequate health literacy. These factors contribute to existing health inequities. Rethinking and redesigning our health care through the guidance of innovative clinics and programs is needed to address these inequities and care for these individuals effectively. This webinar will review current models and strategies that could be widely adopted in health care. These steps can make health care more inclusive and equitable.

This webinar is free and open to the public, but registration is required. Communication Access Realtime Translation (CART) services will be available to provide live closed captions.

In addition, this webinar has been approved for CME credit. The University of Michigan Medical School is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. The UM Medical School designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credit(s)TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

To register for CME credit, you must log in or create an account via the MiCME website at https://ww2.highmarksce.com/micme/activity/202212022C The webinar registration and CME registration must be completed to receive CME credit for attending the event.

The development of this webinar was supported by a grant from the National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR #90RTHF0001).

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Presentation Fri, 25 Mar 2022 14:47:13 -0400 2022-04-14T14:00:00-04:00 2022-04-14T15:00:00-04:00 Off Campus Location Inter-university Consortium for Political and Social Research Presentation IDEAL RRTC April 14, 2022 Webinar Flyer
Reimagining Primary Health Care for Individuals with Disabilities (April 14, 2022 2:00pm) https://events.umich.edu/event/93875 93875-21709211@events.umich.edu Event Begins: Thursday, April 14, 2022 2:00pm
Location: Off Campus Location
Organized By: ICPSR at the University of Michigan Institute for Social Research

Thursday, April 14, 2022, 2:00 - 3:00 p.m. Eastern Time

Registration link: https://bit.ly/3D3gwHB

Continuing Medical Education Credit Information
The University of Michigan Medical School is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. The University of Michigan Medical School designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Register for CME credit by going to https://ww2.highmarksce.com/micme/activity/202212022C

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Workshop / Seminar Wed, 23 Mar 2022 15:05:18 -0400 2022-04-14T14:00:00-04:00 2022-04-14T15:00:00-04:00 Off Campus Location ICPSR at the University of Michigan Institute for Social Research Workshop / Seminar IDEAL RRTC Disability Webinar Series: Reimagining Primary Health Care for Individuals with Disabilities
Breaking barriers to drug and cellular delivery for cancer and other diseases (April 14, 2022 3:30pm) https://events.umich.edu/event/94382 94382-21736329@events.umich.edu Event Begins: Thursday, April 14, 2022 3:30pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: Biomedical Engineering

Abstract:
A myriad of challenges plague current efforts toward safe and effective disease treatment. In the realm of small molecule drugs and biologicals, systemic administration leads to diffuse biodistribution and systemic side effects that limit doses and efficacy. Local depot can overcome some of these challenges, but these suffer from depot exhaustion and dose-limiting local impact. With cellular therapeutics, a costly and labor-intensive manufacturing process inflates the price and limits patient access. This seminar will describe our lab’s efforts to tackle the challenges of therapeutic delivery and access through the development of two technologies. First, we have developed injectable drug-eluting depots that can be repeatedly and noninvasively refilled by systemic administration of inert protodrug refills. Refillable depots enable repeat local drug presentation, temporal regulation, and the prospect of changing drug or dose with disease progression. Second, we have developed biomaterial scaffolds that recapitulate the key functions of ex vivo CAR-T cell production (activation, transduction, expansion) inside the body, reducing CAR-T cell manufacturing from the conventional 4-8 weeks of effort to a single day. The application and utility of these technology in both cancer as well as other diseases will be highlighted.
Bio:
Yevgeny is a Joint Assistant Professor in the Department of Biomedical Engineering at UNC – Chapel Hill and NC State – Raleigh. He earned dual B.A. degrees in Chemistry and Biophysics with minors in Math and Philosophy. He obtained his PhD in Organic Chemistry at Harvard University, developing directed evolution technologies with Prof. David R. Liu. Dr. From there, he went on to do a postdoctoral fellowship at the Wyss Institute at Harvard with Prof. David Mooney, developing controlled release drug delivery technologies for cancer and regenerative medicine. He joined UNC/NC State in 2017, with research interests that span organic synthetic chemistry, materials science and pharmacology. Dr. Brudno’s research rooted in the belief that advances in Chemistry and the basic molecular sciences can generate meaningful change in how therapies are designed, produced, and administered. More information about his group’s work can be found at https://pharmaco.bme.unc.edu/.

Zoom Link: https://umich.zoom.us/j/96508834308

Organized by:
Dr. Brendon Baker,
Assistant Professor, Biomedical Engineering

Dr. David Nordsletten,
Associate Professor, Department of Biomedical Engineering and Cardiac Surgery

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Workshop / Seminar Tue, 05 Apr 2022 16:09:14 -0400 2022-04-14T15:30:00-04:00 2022-04-14T16:30:00-04:00 Lurie Biomedical Engineering (formerly ATL) Biomedical Engineering Workshop / Seminar BME 500 Seminar
BioArtography - Call for Images (April 15, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742277@events.umich.edu Event Begins: Friday, April 15, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-15T00:00:00-04:00 2022-04-15T23:59:00-04:00 BioArtography Other U-M BioArtography
BioArtography - Call for Images (April 16, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742278@events.umich.edu Event Begins: Saturday, April 16, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-16T00:00:00-04:00 2022-04-16T23:59:00-04:00 BioArtography Other U-M BioArtography
BioArtography - Call for Images (April 17, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742279@events.umich.edu Event Begins: Sunday, April 17, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-17T00:00:00-04:00 2022-04-17T23:59:00-04:00 BioArtography Other U-M BioArtography
BioArtography - Call for Images (April 18, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742280@events.umich.edu Event Begins: Monday, April 18, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-18T00:00:00-04:00 2022-04-18T23:59:00-04:00 BioArtography Other U-M BioArtography
The Promise of Inclusivity in Biosocial Research - Lessons from Population-based Studies (April 18, 2022 12:00pm) https://events.umich.edu/event/92210 92210-21688190@events.umich.edu Event Begins: Monday, April 18, 2022 12:00pm
Location: Off Campus Location
Organized By: Institute for Social Research

Inclusive Research Matters Series
The Promise of Inclusivity in Biosocial Research - Lessons from Population-based Studies
April 18, 2022, noon ET via Zoom

Speakers:
- Jessica Faul, Research Associate Professor, SRC, Institute for Social Research
- Colter Mitchell, Research Associate Professor, SRC, Institute for Social Research

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Lecture / Discussion Thu, 10 Feb 2022 14:42:54 -0500 2022-04-18T12:00:00-04:00 2022-04-18T13:10:00-04:00 Off Campus Location Institute for Social Research Lecture / Discussion flyer
BioArtography - Call for Images (April 19, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742281@events.umich.edu Event Begins: Tuesday, April 19, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-19T00:00:00-04:00 2022-04-19T23:59:00-04:00 BioArtography Other U-M BioArtography
LHS Collaboratory (April 19, 2022 11:00am) https://events.umich.edu/event/93101 93101-21700618@events.umich.edu Event Begins: Tuesday, April 19, 2022 11:00am
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Presentation 1:
Medical AI - Three Common Myths on the Path from Code to Clinic
Alan Karthikesalingam, MD, PhD
Research Lead, Google Health UK at Google

In this talk, Alan Karthikesalingam will discuss lessons learned in Google's experiences of taking medical AI systems from early research to clinical implementation.

Presentation 2:
Medical AI - Raising the Bar on Evidence Standards
Xiao Liu, MBChB, PhD(link is external)
Ophthalmologist and Clinical Researcher
University Hospitals Birmingham NHS Foundation Trust University of Birmingham, UK

In this talk, Xiao Liu will discuss existing and new clinical evidence standards as applied to medical AI systems. Her talk will focus on recently published standards to ensure transparency and reproducibility of clinical evidence underpinning medical AI systems, including reporting guidelines such as SPIRIT-AI and CONSORT-AI.

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Lecture / Discussion Tue, 08 Mar 2022 00:04:28 -0500 2022-04-19T11:00:00-04:00 2022-04-19T12:30:00-04:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion Collaboratory logo
Perspectives on Leadership from the Nation's Doctor (April 19, 2022 4:00pm) https://events.umich.edu/event/94250 94250-21726704@events.umich.edu Event Begins: Tuesday, April 19, 2022 4:00pm
Location: Off Campus Location
Organized By: School of Public Health

Join us for a virtual conversation with Dr. Jerome Adams and School of Public Health Dean DuBois Bowman. As the 20th U.S. Surgeon General and a prior member of the President’s Coronavirus task force, Dr. Adams has been at the forefront of America’s most pressing health challenges. Dr. Adams was appointed as a Presidential Fellow and the Executive Director of Purdue's Health Equity Initiatives on October 1, 2021. He is also a Distinguished Professor of Practice in the departments of Pharmacy Practice and Public Health. Dr. Adams is a licensed anesthesiologist with a master’s degree in public health, and ran the Indiana State Department of Health prior to becoming Surgeon General. This event is part of the School of Public Health's leadership speaker series "Ahead of the Curve." It is free and open to the public.

Please register to receive the streaming link.

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Livestream / Virtual Thu, 31 Mar 2022 23:08:22 -0400 2022-04-19T16:00:00-04:00 2022-04-19T17:00:00-04:00 Off Campus Location School of Public Health Livestream / Virtual Doctor Jerome Adams wearing his Public Health Corp uniform adorned with medals sitting in front of the American flag.
BioArtography - Call for Images (April 20, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742282@events.umich.edu Event Begins: Wednesday, April 20, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-20T00:00:00-04:00 2022-04-20T23:59:00-04:00 BioArtography Other U-M BioArtography
BioArtography - Call for Images (April 21, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742283@events.umich.edu Event Begins: Thursday, April 21, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-21T00:00:00-04:00 2022-04-21T23:59:00-04:00 BioArtography Other U-M BioArtography
Integration of Extracellular Matrix of Chondrogenic Pellet Cultures with Chondrocyte-Binding Peptide (April 21, 2022 12:00pm) https://events.umich.edu/event/94519 94519-21747487@events.umich.edu Event Begins: Thursday, April 21, 2022 12:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Articular cartilage injuries (ACIs), which predominantly affect about 37% of young high-level athletes and around 40% of adults over the age of 65, consist of acute and intense joint loading causing sharp pain, joint dysfunction, effusion, and a potential progression to joint degeneration. ACIs are characterized by several severities of lesions, namely low-grade or chondral lesions (grades 1-3) that do not fully reach the bone and are characterized by cartilage swelling or partial-thickness loss, and full-thickness or subchondral lesions (grade 4) that do fully reach the bone. Although intrinsic healing is possible in both cases, these injuries collectively disrupt the integration of the cartilage extracellular matrix and consequently interrupt mechanical load distribution throughout the cartilage and joint as a whole. The mechanical mismatch can eventually lead to osteoarthritis, which leads to the progressive loss of cartilage, destruction of the subchondral bone, and deterioration of ligaments, among other damaging effects, as well as a detrimental loss of aggrecan, an important component of cartilage. Current interventions to aid in the repair of cartilage include microfracture,osteochondral autograft transplantation, and autologous chondrocyte implantation. These surgeries can aid in providing improved temporary comfort to the patient and artificial repairs to the site of injury but fail in significantly reintegrating the cartilage extracellular matrix and maintaining the mechanical load distribution present prior to the injury.

Therefore, this project seeks to utilize chondrocyte-binding peptide RLD-RLD to improve extracellular matrix integration at the interface between cartilage. The first part of the study consists of verifying the adsorption of RLD-RLD to ATDC5 chondrogenic cells. These cells were grown in both 2D as a monolayer and 3D as cell pellets, and the adsorption of RLD-RLD and VTK, a peptide previously identified to have a high affinity for apatite, was measured. After ensuring the adsorption of RLD-RLD to ATDC5 cells, 3D ATDC5 pellets were combined after a 7-day culture period and the peptide was added to chondrogenic media for 3- and 7-day periods. Pellets were then sectioned and stained to visualize the integration of ECM at the interface, and a quantitative scoring system was used to characterize the pellets with and without the use of the peptide. Finally, pellets were again grown for a 7-day period and then combined along with RLD-RLD for a 3-day period, and atomic force microscopy was performed on the pellets to determine the mechanical integration strength between the pellets.

Overall, the data demonstrated an increase in integration at the interface between pellets with the chondrocyte-binding peptide compared to the control group with no peptide. These findings can be utilized for future investigation of the use ofRLD-RLD in many cartilage applications, specifically in using a form of this peptide for integration at the cartilage-bone interface, which would be useful for the healing of subchondral lesions. It would also be beneficial to continue these studies in vivo with a mice model to investigate its advantage when applied directly to injured cartilage.

DATE: Thursday, April 21, 2022
TIME: 12:00 PM (Noon)
Zoom: https://umich.zoom.us/j/99821287326 (Passcode: 926901)
Chair: Prof. David Kohn

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Lecture / Discussion Mon, 11 Apr 2022 08:56:53 -0400 2022-04-21T12:00:00-04:00 2022-04-21T13:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Master's Defense
Studying Immunosuppressive Tumor Microenvironments for the application of CAR-T cell therapy in treatment of Metastatic Triple Negative Breast Cancer (April 21, 2022 12:30pm) https://events.umich.edu/event/94645 94645-21753255@events.umich.edu Event Begins: Thursday, April 21, 2022 12:30pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Triple Negative Breast Cancer (TNBC) is a highly aggressive form of breast cancer that makes up approximately 10 - 15 percent of cases. This specific subtype is characterized by the absence of Estrogen Receptors, Progesterone Receptors and Human Epidermal Growth Factor Receptor 2 (HER-2) on its cells. These three receptors are often targeted in commonly used breast cancer treatments and their absence limits treatment options for patients suffering with TNBC. A common treatment regimen for TNBC typically comprises a combination of chemotherapy followed by surgical intervention and radiation. However, this has many systemic side effects and limited efficacy in clearing advanced disease. The five-year survival rate for patients who suffer from a metastatic form of TNBC is 11% - making the prognosis for these patients quite devastating.

Chimeric Antigen Receptor (CAR) T cell therapy is an exciting new development in the field of cancer immunotherapy. T cells are engineered to have a receptor that targets a specific antigen that is commonly expressed on the surface of cancer cells. This therapy has been granted FDA approval largely for the treatment of blood related cancer such as leukemias and lymphomas through targeting the highly expressed CD19 antigen. Currently, work is being done to extend this promising therapy for the treatment of solid tumors (such as TNBC) in order to give people who suffer from this disease an effective alternative treatment. However, this has proven to be quite difficult for several reasons - one of them being the presence of an immunosuppressive tumor microenvironment.

Throughout this body of work, a CD19-expressing 4T1 murine triple negative breast cancer cell line was used as a model system to explore the immunosuppressive microenvironment in metastasizing TNBC and elucidate specific cellular mechanisms that cause suppression of CART therapy. First, T cell proliferation was measured in normal and conditioned media that were made from the primary 4T1 and metastatic 4T1 lung tumors grown in balb/c mice at the Day 7, 14 and 21 timepoints. The cytotoxicity of CD19 positive CAR-T cells was then measured when co-cultured with CD19-expressing 4T1 cells in the conditioned media from the metastatic 4T1 lung tumors. Next, single-cell RNA sequencing was performed on lungs from tumor-bearing mice in order to characterize the metastatic microenvironment and find potential transcription factors and specific cellular pathways that were upregulated. Finally, T cells were transfected with fluorescent transcription factor reporters in order to confirm the activation of specific transcription factors when cultured in the conditioned medias from metastatic 4T1 lung tumors.

As a result of these experiments, the presence of an immunosuppressive microenvironment that is specific to the conditioned media produced from metastatic 4T1 lung tumors at the Day 21 time point was shown. Results obtained also suggested the role of neutrophils in activating the transcription factor STAT3 which in turn upregulates the activity of the pd1/pdl1 pathway and leads to the suppression of T cell function in the metastatic microenvironment of Triple Negative Breast Cancer. Identifying these mechanisms are crucial as they will help improve CAR-T cell therapy and extend their application to the treatment of solid tumors.

DATE: Thursday, April 21, 2022
TIME: 12:30 PM
Zoom: https://umich.zoom.us/j/92806777883
Chair: Prof. Lonnie Shea

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Lecture / Discussion Thu, 14 Apr 2022 14:50:58 -0400 2022-04-21T12:30:00-04:00 2022-04-21T13:30:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Event
BioArtography - Call for Images (April 22, 2022 12:00am) https://events.umich.edu/event/73295 73295-21742284@events.umich.edu Event Begins: Friday, April 22, 2022 12:00am
Location:
Organized By: BioArtography

BioArtography is now collecting digital images for its 2022 collection, which will debut at the Ann Arbor Art Fair in July 2022!

The BioArtography program, a unique blend of art and science, captures the microscopic beauty of cells in their environment, affording the public a deeper understanding of state-of-the-art biomedical research at the University of Michigan. The goal of our program is to provide support for training of the next generation of scientists, while simultaneously informing and engaging the public about important new developments in health and disease.

The top 3 images selected by our jury will receive $100!

Please click the BioArtography Image Submission Info link for all details.

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Other Fri, 08 Apr 2022 15:28:00 -0400 2022-04-22T00:00:00-04:00 2022-04-22T23:59:00-04:00 BioArtography Other U-M BioArtography
Africa-US Collaborations in Health: Observations from Kenya (April 28, 2022 10:00am) https://events.umich.edu/event/93873 93873-21709208@events.umich.edu Event Begins: Thursday, April 28, 2022 10:00am
Location: Michigan League
Organized By: Center for Global Health Equity

Dr. Lukoye Atwoli, professor of psychiatry at Aga Khan University and a leader of health initiatives around the globe, will share his reflections on collaborations between African and US partners that have advanced health in recent decades. Dr. Atwoli will share lessons he and others learned from their engagement with a range of projects, including the AMPATH research network.

This in-person discussion with a global health leader is a unique opportunity, especially for anyone interested in health sciences research and other collaborations in Africa.

Light refreshments will be served. RSVP at myumi.ch/pZd4y.

Co-Sponsored by the African Studies Center and the Center for Global Health Equity

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Presentation Wed, 23 Mar 2022 14:32:59 -0400 2022-04-28T10:00:00-04:00 2022-04-28T11:00:00-04:00 Michigan League Center for Global Health Equity Presentation Dr. Lukoye Atwoli addresses AKU and U-M colleagues in Nairobi, Kenya
Defined Culture Environments Create an Improved Human Intestinal Organoid Model System to Study Intestinal Development (April 28, 2022 3:00pm) https://events.umich.edu/event/94646 94646-21753258@events.umich.edu Event Begins: Thursday, April 28, 2022 3:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Biomedical Engineering

Organoids are small stem cell-derived tissues that mimic some aspects of the structure and function of the organs they are modelled after. Thus, organoids provide a 3D model for studying human development and disease in a complex human-derived in vitro system, and offer advantages over traditionally utilized 2D in vitro cell culture platforms or in vivo animal models. Intestinal organoids have been well characterized and used for over a decade to model intestinal pathologies and advance our understanding of intestinal biology. However, intestinal organoid models have been limited by a reliance on commercial basement membrane extracellular matrix (ECM) products such as Matrigel which introduce experimental variability, limit experimental control, and are unsuitable for downstream clinical applications due to their xenogeneic origin. Additionally, current intestinal organoids are relatively immature and do not contain all of the key cell types found in the human intestine. In particular, a serosal mesothelium, the outermost layer of the intestine that provides a protective boundary for the gut, has not been observed within previous in vitro intestinal models.

In this dissertation, I describe improved culture methods for pluripotent stem cell-derived human intestinal organoids (HIOs) that eliminate reliance on Matrigel and more faithfully recapitulate the organization of the human small intestine. I show that HIOs do not require biochemical support from a 3D ECM matrix as they contain both epithelial and mesenchymal compartments, which enables the formation of a supportive niche within the organoid. Thus, HIOs can be cultured in bioinert environments including unmodified alginate hydrogels and even suspension culture. Alginate and suspension culture provide simple, cost effective culture systems for HIOs that offer increased experimental control and decreased variability compared to Matrigel. I demonstrate that alginate and suspension culture are effective replacements for Matrigel that support the HIO epithelium, as HIOs cultured in alginate and suspension give rise to expected intestinal epithelial cell types.

Additionally, HIOs cultured in bioinert conditions (alginate or suspension) form an organized outer mesenchymal layer that closely resembles the human intestine. Strikingly, HIOs cultured in alginate and suspension form an outer serosal mesothelium that has not been previously observed in Matrigel HIOs. This serosa formation is enhanced in suspension culture compared to alginate. I characterized HIO-serosa to demonstrate that it is molecularly and functionally similar to human intestinal serosal mesothelium. I then utilized suspension HIOs as a model to investigate serosal development and identified roles for HH and WNT signaling in human intestinal serosa formation and patterning. Overall, this work provides improved, defined culture methods for human intestinal organoids that better recapitulate the native intestine for enhanced studies of intestinal development and disease modelling.

Date: Thursday, April 28, 2022
Time: 3:00 PM EST
Location: BSRB Kahn Auditorium
Chair: Professor Jason R. Spence

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Lecture / Discussion Thu, 14 Apr 2022 14:55:51 -0400 2022-04-28T15:00:00-04:00 2022-04-28T16:00:00-04:00 Taubman Biomedical Science Research Building Biomedical Engineering Lecture / Discussion BME PhD Defense
The Heart of Collaborations: Exploring future cardiovascular joint research between Michigan Medicine and PKUHSC (April 29, 2022 7:00am) https://events.umich.edu/event/94586 94586-21751046@events.umich.edu Event Begins: Friday, April 29, 2022 7:00am
Location: Off Campus Location
Organized By: UMMS Global REACH

Join experts from Michigan Medicine and PKUHSC to explore future collaborations in cardiovascular medicine. Cardiovascular research has long been a pillar of the Joint Institute, with 15 funded projects since the JI was first established in 2010. What does the future joint cardiovascular research look like? Experts from both PKUHSC and U-M will discuss their work and explore potential projects and partnerships in this area.

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Livestream / Virtual Wed, 13 Apr 2022 09:09:28 -0400 2022-04-29T07:00:00-04:00 2022-04-29T08:30:00-04:00 Off Campus Location UMMS Global REACH Livestream / Virtual Joint Institute Logo
Project Management Certification (May 1, 2022 1:00pm) https://events.umich.edu/event/91083 91083-21677009@events.umich.edu Event Begins: Sunday, May 1, 2022 1:00pm
Location: Off Campus Location
Organized By: Tauber Institute for Global Operations

Once again, the Tauber Institute, in conjunction with the International Project Management Association (IPMA), is sponsoring a Project Management certification class and exam for graduate business and engineering students, alumni, and staff.

In order to participate, you will need to reflect upon a project management experience (for example: a work project, an engineering design experience/senior capstone, Ross' MAP project, Tauber team project, etc). If you cannot make it to the classes (due to project travel, MAP, or other another class), the sessions will be recorded. Homework (mastery verification) will be required after each session.

The cost to an individual to take the exam is normally $595, however, Tauber is offering the exam at a substantial discount to non-Tauber students:
$550 for U-M alumni or public
$425 for U-M students, U-M employees, or Tauber alumni
$325 for U-M Ross School of Business or U-M College of Engineering staff
$225 for Tauber Institute students
$145 for previous students to retake the exam

Certification is valid for 5 years. Three certification classes will be taught by Professor Eric Svaan on the following dates:

Sunday, March 13 (1:00 pm - 4:00 pm)
Sunday, March 27 (1:00 pm - 4:00 pm)
Sunday, April 10 (1:00 pm - 4:00 pm)

The certification exam, administered by IPMA-USA is scheduled for May 1, 2022 (11:00 am) virtually. Successfully passing the exam will yield IPMA's Level D certification (Certified Project Management Associate).

Project Management is a powerful skill set to have in your toolbox as you look for full-time employment!

REGISTRATION: Please register through iMpact by clicking here:
https://www.bus.umich.edu/Conferences/Project-Management-Certification-2022/Default.aspx

NOTE: The non-refundable fees

HOSTED BY: Tauber Institute for Global Operations. For questions about this event, please contact tauberinstitute@umich.edu or visit tauber.umich.edu.

What is IPMA Level D® (Certified Project Management Associate)? The IPMA Level D is an internationally recognized entry-level qualification in the area of project management. This designation, which demonstrates the individual's ability to understand the basics of project management, is similar to the exam-oriented, knowledge-based certifications of other major Project Management associations. For many, Level D® is the first step towards a professional project or program manager role. It is the first step in a sequence (C, B and A) to be earned by demonstration of success in larger PM responsibility sets.

For more information,
Visit tauber.umich.edu or call 734-647-1333
Connect via email to Diana Crossley dianak@umich.edu

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Class / Instruction Mon, 21 Feb 2022 15:54:30 -0500 2022-05-01T13:00:00-04:00 2022-05-01T16:00:00-04:00 Off Campus Location Tauber Institute for Global Operations Class / Instruction Certificate photo
A Multicellular, Biomaterial-based Platform for the Engineering of Vascularized Bone (May 9, 2022 11:00am) https://events.umich.edu/event/94843 94843-21776805@events.umich.edu Event Begins: Monday, May 9, 2022 11:00am
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: Biomedical Engineering

Cell-based tissue engineering offers the potential to greatly improve the treatment of large and complex bone defects by addressing the main shortcomings associated with current bone grafting procedures. A main challenge is the ischemic environment that can result from traumatic bone injury, resulting in the death of transplanted cells and tissue constructs. Achieving an adequate vascular supply is a critical barrier preventing the translational success of cell-based regeneration approaches. Therefore, a variety of strategies have been developed to prevascularize engineered tissue constructs prior to transplantation. Adult mesenchymal stromal cells (MSC) and endothelial cells (EC) are key players in native orthopaedic tissue regeneration and vascularization, and represent promising cell types for tissue engineering strategies to create vascularized bone. However, to effectively harness the regenerative potential of MSC, the appropriate phenotype must be achieved before implantation. A main challenge in engineering vascularized bone tissue is creating an appropriate culture environment to support multiple cell phenotypes. Therefore, this work focuses on designing a cell-based, biomaterial-enabled strategy that provides spatiotemporal control of key microenvironmental cues to support the co-development of osseous and vascular tissues, with the end goal of generating vascularized, bone-forming constructs.

First, this thesis explores how temporal control of the culture environment can be used to maintain preformed vessels and subsequent osteogenic development in engineered tissue constructs. To mimic the sequential process of native bone development, in which vascularization precedes tissue ossification, we generated cell-laden hydrogel constructs cultured in vasculogenic growth medium to induce vessel development, and subsequently supplemented the medium with osteoinductive components to promote osteogenic differentiation. Our results revealed conflicting effects of the two culture environments, in which osteoinductive factors compromised cellular viability and MSC pericyte-like function, leading to ~93% regression of preformed vessels. Further, vasculogenic culture conditions inhibited MSC-mediated matrix mineralization as evidenced by impaired calcium deposition.

Next, this thesis describes the development and characterization of a modular biomaterial approach that provides control of discrete environmental properties designed to promote vasculogenic and osteogenic tissue development. Separate populations of cell-laden microtissues were fabricated and independently cultured under specific differentiation conditions to support either osteogenic or pericyte-like lineage commitment of MSC. This approach enabled the formation of primitive osteogenic microtissues exhibiting mineralization of the extracellular matrix, and vascular microtissues with demonstrated EC sprouting potential. The combination of microtissues led to the generation of a multiphase construct that supported extensive vessel development. While osteogenic activity was maintained without exogenous osteoinductive factors, the vasculogenic culture environment was not conducive for sustained mineralization.

Lastly, this thesis describes a novel approach incorporating the modular biomaterial platform with a biomimetic induction process emulating the native endochondral ossification (EO) pathway to better couple vascular and osteogenic tissue development. Chondrogenically-primed MSC were matured to hypertrophy to form hypertrophic pellets resembling EO, as evidenced by MMP-mediated remodeling and mineralization of the formed cartilaginous matrix. Hypertrophic induction of MSC was associated with secretion of distinct angiogenic factors which stimulated EC vasculogenesis. When combined with vasculogenic microtissues, hypertrophic pellets supported robust vessel development and cell-mediated mineralization without exogenous vasculogenic medium or osteoinductive components.

Overall, this dissertation presents an attractive strategy for generating vascularized bone-like tissue. By integrating the modular biomaterial platform with an EO-based induction process, we successfully leveraged physiologic cues of hypertrophic MSC to achieve concomitant vasculogenic and osteogenic development.

Date: Monday, May 9, 2022
Time: 11:00 AM
Location: 1130 LBME and Zoom (https://umich.zoom.us/j/96133803682 Passcode: bones)
Chair: Dr. Jan Stegemann

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Presentation Wed, 27 Apr 2022 14:28:01 -0400 2022-05-09T11:00:00-04:00 2022-05-09T12:00:00-04:00 Lurie Biomedical Engineering (formerly ATL) Biomedical Engineering Presentation BME PhD Defense
2022 Caswell Diabetes Institute - Metabolism, Obesity & Diabetes (CDI-MOD) and the Frontiers in Diabetes Complications Symposium (May 11, 2022 8:00am) https://events.umich.edu/event/94750 94750-21764822@events.umich.edu Event Begins: Wednesday, May 11, 2022 8:00am
Location: North Campus Research Complex Building 18
Organized By: Caswell Diabetes Institute

The CDI-MOD and Frontiers in Diabetes Complications Symposium provides a forum for intellectual exchange on topics associated with diabetes, obesity, metabolism and related complications among established investigators, junior faculty, students, and other researchers at the University of Michigan (U-M) and surrounding areas. This symposium features two days of invited speakers with a lively debate, poster session and data blitz, providing time for discussion and exploration of new collaborations. Speakers include a combination of researchers of international stature from outside of U-M and junior and senior faculty within the University. Symposium participants will enhance their knowledge and understanding of the latest advances in basic, translational and clinical research as well as the latest advances in the care and treatment of diabetes, obesity, metabolism and related complications. After this activity, participants will be able to elucidate and predict more clear causes of diabetes and metabolic diseases and utilize this information to guide future research. The target audience includes physicians, house officers, medical students, technicians, administrators and other healthcare professionals.

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Conference / Symposium Wed, 20 Apr 2022 15:14:09 -0400 2022-05-11T08:00:00-04:00 2022-05-11T18:00:00-04:00 North Campus Research Complex Building 18 Caswell Diabetes Institute Conference / Symposium CDI-MOD Complications Schedule-At-A-Glance
2022 Caswell Diabetes Institute - Metabolism, Obesity & Diabetes (CDI-MOD) and the Frontiers in Diabetes Complications Symposium (May 12, 2022 8:00am) https://events.umich.edu/event/94750 94750-21764823@events.umich.edu Event Begins: Thursday, May 12, 2022 8:00am
Location: North Campus Research Complex Building 18
Organized By: Caswell Diabetes Institute

The CDI-MOD and Frontiers in Diabetes Complications Symposium provides a forum for intellectual exchange on topics associated with diabetes, obesity, metabolism and related complications among established investigators, junior faculty, students, and other researchers at the University of Michigan (U-M) and surrounding areas. This symposium features two days of invited speakers with a lively debate, poster session and data blitz, providing time for discussion and exploration of new collaborations. Speakers include a combination of researchers of international stature from outside of U-M and junior and senior faculty within the University. Symposium participants will enhance their knowledge and understanding of the latest advances in basic, translational and clinical research as well as the latest advances in the care and treatment of diabetes, obesity, metabolism and related complications. After this activity, participants will be able to elucidate and predict more clear causes of diabetes and metabolic diseases and utilize this information to guide future research. The target audience includes physicians, house officers, medical students, technicians, administrators and other healthcare professionals.

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Conference / Symposium Wed, 20 Apr 2022 15:14:09 -0400 2022-05-12T08:00:00-04:00 2022-05-12T17:00:00-04:00 North Campus Research Complex Building 18 Caswell Diabetes Institute Conference / Symposium CDI-MOD Complications Schedule-At-A-Glance
2022 MaryFran Sowers Memorial Symposium (Day 1, May 12) (May 12, 2022 1:30pm) https://events.umich.edu/event/92998 92998-21698986@events.umich.edu Event Begins: Thursday, May 12, 2022 1:30pm
Location: Off Campus Location
Organized By: Center for Midlife Science

*featuring the career of Siobán D. Harlow, PhD, (Professor Emerita of Epidemiology, Global Public Health, and Obstetrics & Gynecology)*

**REGISTER TODAY** (In-person and virtual attendance options available)

http://midlifescience.umich.edu/Event_Sowers2022.php

Keynote speaker Dr. Fugate Woods is Professor Emerita, University of Washington School of Nursing, and Co-Director, de Tornyay Center for Healthy Aging.

**May 12 (Thursday)1:30-4:30 pm**
Welcome: SPH Dean Dubois Bowman
Keynote address: Nancy Fugate Woods "Women's Lives, Women's Health Across the Lifespan"

Michael Elliott, PhD: "What Makes a Good Collaboration? An Exemplary Example in My Work with Professor Sioban Harlow"

Kristin Dunkle, PhD: "From Prevalence to Effective Prevention: Evolution of Epidemiological Research on Gender-based Violence"

Alexis Reeves, PhD: "Addressing Racially Diverse Trajectories of Health in Women - Methodological Challenges and Implications"

Reception: Organized by Epidemiology Dept.

Registration required. Please see webpage for more information and registration.
http://midlifescience.umich.edu/SOWERS2022

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Conference / Symposium Fri, 06 May 2022 14:02:54 -0400 2022-05-12T13:30:00-04:00 2022-05-12T16:30:00-04:00 Off Campus Location Center for Midlife Science Conference / Symposium MaryFran Sowers Memorial Symposium featuring the career of Siobán Harlow
Scalable online modeling and perturbations for adaptive neuroscience experiments (May 12, 2022 3:30pm) https://events.umich.edu/event/95066 95066-21788408@events.umich.edu Event Begins: Thursday, May 12, 2022 3:30pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: Biomedical Engineering

Abstract:
Systems neuroscience is increasingly able to leverage new recording tools and statistical analyses to describe the coordinated activity of large neuronal populations, even entire brains. Combined with precise stimulation technologies, we could begin to dissect large-scale circuits in vivo, constructing models that causally relate neural activity to behavior. Perturbative testing of hypothesized brain-behavior links, however, requires statistically efficient methods for both estimating and intervening on population-level neural dynamics in real time. To build neural models online, we describe a new machine learning method that combines fast, stable dimensionality reduction with a soft tiling of the resulting neural manifold, allowing dynamics to be approximated as a probability flow between tiles. This method can be fit efficiently, scales to large populations, and outperforms existing methods when dynamics are noise-dominated or feature multi-modal transition probabilities. Using online modeling, we can also ‘close the loop’ by selecting optimal circuit interventions to create maps of causal influence within large networks. Our algorithm uses online convex optimization and adaptive stimulation selection to quickly infer the binary network connectivity, rendering the inference of networks of tens of thousands of neurons in vivo feasible in a single experiment. We additionally present a neural response optimization method with multi-output Gaussian processes that uses active stimulus selection to acquire data at locations where models are likeliest to be wrong given the data seen so far. These methods, which combine online neural modeling with adaptive intervention, open the door to automated, theory-driven circuit dissection at scale, providing a powerful new means of interrogating neural function.

Bio:
Dr. Anne Draelos is a Postdoctoral Associate in the Pearson Lab at Duke University focused on machine learning and statistical techniques to facilitate real-time analysis of high-dimensional neural and behavioral data. She is currently a Swartz Foundation Fellow for Theory in Neuroscience and received a 2021 Career Awards at the Scientific Interface from the Burroughs Wellcome Fund.

Zoom Link: https://umich.zoom.us/j/91252848761?pwd=MkpCaDRHcjlRRWxuUzFEakQyM1RYUT09

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Lecture / Discussion Tue, 10 May 2022 10:07:27 -0400 2022-05-12T15:30:00-04:00 2022-05-12T16:30:00-04:00 Lurie Biomedical Engineering (formerly ATL) Biomedical Engineering Lecture / Discussion BME Seminar Event
2022 MaryFran Sowers Memorial Symposium (Day 2, May 13) (May 13, 2022 11:00am) https://events.umich.edu/event/93519 93519-21705222@events.umich.edu Event Begins: Friday, May 13, 2022 11:00am
Location: Off Campus Location
Organized By: Center for Midlife Science

*featuring the career of Siobán D. Harlow, PhD*

REGISTER TODAY (in person and virtual attendance options)
http://midlifescience.umich.edu/Event_Sowers2022.php

May 13 (Friday)11:00 am - 1:00 pm
Panel: The Future of Women's Health
Moderator, Nancy Fugate Wood

Panel A: NGO and Practice
With...
Lisa Zook, MPH (InformEd International)
Richa Mittal, MPH (Fair Labor Association)
Alain Mukwege, MD (Panzi Foundation)

Panel B: Research
With...
Alexis Handal, PhD (U of M)
Carrie Karvonen-Gutierrez, PhD (U of M)
Lynda Lisabeth, PhD (U of M)
Hilda Garcia, PhD (Colegio de Frontera Norte)

Registration required. Please see webpage for more information and registration.
http://midlifescience.umich.edu/SOWERS2022

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Conference / Symposium Mon, 25 Apr 2022 13:38:04 -0400 2022-05-13T11:00:00-04:00 2022-05-13T13:00:00-04:00 Off Campus Location Center for Midlife Science Conference / Symposium MaryFran Sowers Memorial Symposium featuring the career of Siobán Harlow
Clinical Simulation Center Brown Bag Discussion (May 13, 2022 12:00pm) https://events.umich.edu/event/94796 94796-21768749@events.umich.edu Event Begins: Friday, May 13, 2022 12:00pm
Location: Off Campus Location
Organized By: Clinical Simulation Center

Stephen Dowker will discuss the simulation work of the Department of Learning Health Sciences, Cardiology, and Emergency Medicine colleagues to improve cardiac arrest care in the prehospital setting.

Come join the discussion on Zoom.

Link: https://umich.zoom.us/j/96776571266?pwd=RnB6ZFdnMmcyYm9ZZEpnZ0tFMEx1dz09

Meeting ID: 967 7657 1266
Passcode: 48109

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Lecture / Discussion Fri, 22 Apr 2022 18:01:54 -0400 2022-05-13T12:00:00-04:00 2022-05-13T13:00:00-04:00 Off Campus Location Clinical Simulation Center Lecture / Discussion Stephen Dowker, Research Area Specialist Associate - M-RISE | EPOC
Effects of the Pandemic on Trauma and Abuse within Families and Communities (May 17, 2022 4:00pm) https://events.umich.edu/event/94935 94935-21786943@events.umich.edu Event Begins: Tuesday, May 17, 2022 4:00pm
Location: Off Campus Location
Organized By: Michigan Medicine

This talk, which serves as the 14th Annual Susan B. Meister Lecture in Child Health Policy, aims to focus attention on the impact of the pandemic on trauma and abuse in children and older adults.

The event will take place via Zoom. Registration is free, but required, at chear.org/meister-lecture

Keynote Speaker:
Terry Fulmer, PhD, RN, FAAN
President, The John A. Hartford Foundation

Panelists:
Debra Chopp, JD
Associate Dean for Experiential Education
Clinical Professor of Law
Director, Pediatric Advocacy Clinic

Todd I. Herrenkohl, PhD, MSW
Marion Elizabeth Blue Professor of
Children and Families
School of Social Work

Preeti N. Malani, MD, MSJ
Chief Health Officer
Professor of Medicine, Michigan Medicine
Infectious Disease

Sponsored by the Susan B. Meister Child Health Evaluation and Research (CHEAR) Center within the Department of Pediatrics - and the CHEAR Faculty Executive Representatives, a collaborative of the Schools of Business, Dentistry, Education, Law, Medicine, Nursing, Pharmacy, Public Health, Public Policy, & Social Work

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Lecture / Discussion Tue, 03 May 2022 12:10:19 -0400 2022-05-17T16:00:00-04:00 2022-05-17T17:30:00-04:00 Off Campus Location Michigan Medicine Lecture / Discussion Terry Fulmer, Ph.D., R.N., FAAN
Glenn V. Edmonson Lecture & 2022 Biomedical Engineering Symposium (May 18, 2022 10:00am) https://events.umich.edu/event/94970 94970-21788170@events.umich.edu Event Begins: Wednesday, May 18, 2022 10:00am
Location: Palmer Commons
Organized By: Biomedical Engineering

The Inaugural Glenn V. Edmonson Lecture and 2022 Biomedical Engineering Symposium are intended to build the BME community across campus and honor the legacy of the first graduate chair of the Biomedical Engineering program. These events will provide a forum for BME faculty and students campus-wide along with our collaborators to present current research progress and discuss future research opportunities at the interface of engineering and medicine.

The events will take place on Wednesday, May 18th, from 10:00 AM - 5:00 PM at Palmer Commons (4th Floor). Please RSVP by Friday, May 6th, 2022.

RSVP Link: https://forms.gle/QB7kS8UnQftWrZaX9

Schedule:
10:00 AM - 10:15 AM Welcome and Introduction from BME Interim Chair, Mary-Ann Mycek Ph.D., and Symposium Chairs, Rhima Coleman, Ph.D., and Tim Bruns, Ph.D.

10:15 AM - 11:05 AM Cell and In vitro
Sue Brooks Herzog, Ph.D.
Sherman Fan, Ph.D.
Geeta Mehta, Ph.D.

11:05 AM - 11:15 AM Break

11:15 AM - 12:05 PM In Vivo
Jiande Chen, Ph.D.
Megan Killian, Ph.D.
Cindy Chestek, Ph.D.

12:05 PM - 1:00 PM LUNCH BREAK - with Poster Viewing

1:00 PM - 1:50 PM Computational
Indika Rajapakse, Ph.D.
David Nordsletten, Ph.D.
Ellen Arruda, Ph.D.

1:50 PM - 2:00 PM Break

2:00 PM - 2:50 PM Clinical / Human Subjects
Susan Shore, Ph.D.
Jon-Fredrik Nielsen, Ph.D.
David Zopf, M.D., M.S.

2:50 PM - 3:00 PM Break

3:00 PM – 4:15 PM Glenn V. Edmonson Lecture
Paul Cederna, M.D. FACS

4:15 PM - 5:00 PM POSTER SESSION and Reception

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Conference / Symposium Wed, 04 May 2022 14:01:07 -0400 2022-05-18T10:00:00-04:00 2022-05-18T17:00:00-04:00 Palmer Commons Biomedical Engineering Conference / Symposium BME Symposium
Wellness on the Wards (May 18, 2022 6:00pm) https://events.umich.edu/event/87837 87837-21647062@events.umich.edu Event Begins: Wednesday, May 18, 2022 6:00pm
Location: Off Campus Location
Organized By: Michigan Medicine Wellness Office

Learn about strategies for improving your wellness while on clinical rotations, and working in the hospital. Share stories with other students, and exchange ideas for supporting one another in this high-intensity setting.

Register to receive zoom link: https://sessions.studentlife.umich.edu/track/event/session/45701

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Well-being Mon, 04 Oct 2021 11:51:14 -0400 2022-05-18T18:00:00-04:00 2022-05-18T19:00:00-04:00 Off Campus Location Michigan Medicine Wellness Office Well-being Wellness Office Logo
Tissue Engineering and Regenerative Medicine Approaches to Study Fat-Cartilage Crosstalk (May 19, 2022 3:00pm) https://events.umich.edu/event/95137 95137-21788505@events.umich.edu Event Begins: Thursday, May 19, 2022 3:00pm
Location: Taubman Library
Organized By: Regenerative Medicine Biosciences Initiative

Dr. Collins received her PhD in Biomedical Engineering in 2017 in Dr. Walter Herzog’s lab at the University of Calgary on diet-induced obesity in a rat model of osteoarthritis. As a Postdoctoral Research Scholar in the Guilak Laboratory at Washington University in St. Louis, Kelsey has created a niche in adipose-cartilage signaling, stem-cell biology, synthetic biology, and drug delivery to evaluate systemic contributors and novel therapeutic strategies in osteoarthritis and rheumatoid arthritis.

This is a hybrid event, in-person at Taubman Library 2901, and also available via Zoom.

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Workshop / Seminar Fri, 13 May 2022 11:56:20 -0400 2022-05-19T15:00:00-04:00 2022-05-19T16:30:00-04:00 Taubman Library Regenerative Medicine Biosciences Initiative Workshop / Seminar Dr. Kelsey Collins
Tissue Engineering and Regenerative Medicine Approaches to Study Fat-Cartilage Crosstalk (May 19, 2022 3:00pm) https://events.umich.edu/event/95137 95137-21788506@events.umich.edu Event Begins: Thursday, May 19, 2022 3:00pm
Location: Off Campus Location
Organized By: Regenerative Medicine Biosciences Initiative

Dr. Collins received her PhD in Biomedical Engineering in 2017 in Dr. Walter Herzog’s lab at the University of Calgary on diet-induced obesity in a rat model of osteoarthritis. As a Postdoctoral Research Scholar in the Guilak Laboratory at Washington University in St. Louis, Kelsey has created a niche in adipose-cartilage signaling, stem-cell biology, synthetic biology, and drug delivery to evaluate systemic contributors and novel therapeutic strategies in osteoarthritis and rheumatoid arthritis.

This is a hybrid event, in-person at Taubman Library 2901, and also available via Zoom.

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Workshop / Seminar Fri, 13 May 2022 11:56:20 -0400 2022-05-19T15:00:00-04:00 2022-05-19T16:30:00-04:00 Off Campus Location Regenerative Medicine Biosciences Initiative Workshop / Seminar Dr. Kelsey Collins
Bone Marrow Stromal Cells Regulate Functional States of ER+ Breast Cancer Cells (May 25, 2022 1:00pm) https://events.umich.edu/event/94936 94936-21786532@events.umich.edu Event Begins: Wednesday, May 25, 2022 1:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Even with targeted therapies, patients with the most common subtype of breast cancer, estrogen-receptor-positive (ER+) disease, face an ongoing, progressively increasing risk of metastases. ER+ breast cancer predominantly metastasizes to bone marrow (~70% of patients with advanced disease). Current hormone therapies frequently suppress, but fail to eliminate, both proliferating and quiescent breast cancer cells in bone marrow. While drug resistance may arise from cancer-cell intrinsic mechanisms, studies implicate interactions between ER+ breast cancer cells and bone marrow mesenchymal stromal cells (MSCs) as a pivotal cause of resistance to hormone therapies and transitions to CSC states. This dissertation focuses on elucidating targetable mechanisms for MSC-induced increases in cancer cell plasticity and resistance to antiestrogenic therapy.

This work began showing that direct co-culture with MSCs induces resistance to antiestrogenic therapy in ER+ breast cancer cells, in part through increases in intracellular iron. Combining iron chelators or novel lysosomal iron-targeting compounds with clinical antiestrogenic therapy reduced resistance of cancer cells to therapy. Next, we showed that co-culture with MSCs increased oxidative metabolism, intracellular ATP, glucose, and metabolic plasticity in ER+ breast cancer cells treated with antiestrogenic therapy, including under conditions of nutrient stress. We successfully limited metabolic plasticity, heterogeneous treatment responses, and drug resistance by inhibiting monocarboxylate transporters. Finally, we utilized a physiologically-relevant 3D co-culture model with MSCs that successfully recapitulated slow proliferation, signaling, and metabolic profiles of disseminated ER+ breast cancer cells. Simultaneous treatment with inhibitors of Akt and thioredoxin reductase effectively reduced cancer burden versus antiestrogenic therapy in both in vitro and in vivo models. By exploiting adaptations of ER+ breast cancer cells to the stromal microenvironment, we identified multiple clinically-actionable approaches to overcome stromal-mediated drug resistance, paving the way toward more effective treatments against bone marrow metastases.

Date: Wednesday May 25, 2022
Time: 1:00 PM
Zoom: https://umich.zoom.us/j/96774775771
Chair: Dr. Gary Luker

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Presentation Tue, 03 May 2022 08:39:58 -0400 2022-05-25T13:00:00-04:00 2022-05-25T14:00:00-04:00 Off Campus Location Biomedical Engineering Presentation BME PhD Defense
7th Annual Gilbert S. Omenn, MD, PhD Lecture (June 3, 2022 10:00am) https://events.umich.edu/event/95013 95013-21788268@events.umich.edu Event Begins: Friday, June 3, 2022 10:00am
Location: Off Campus Location
Organized By: Omenn Lecture

Talk Title: Biomedical Data Science: The Hope, Hype, and Promise

Abstract: Data science was introduced as a “new” profession in the early 1960s, yet the Office of Data Science Strategy at the National Institutes of Health (NIH) was not established until 2018. Artificial intelligence (AI) traces its roots to at least the 1950s, with its first application as an expert system in medicine in the early 1970s. Yet, the NIH Working Group on AI was not established until 2018 as well, with their first report issued in 2019. This is not to say that these topics have been neglected over the past half-century, but it begs the question of why have they only now come to the forefront of biomedicine? We have seen multiple AI booms and busts, each of which has caused massive hype, dream crushing failures, and notable advancements (some more flashy than others) along the way. This talk is not intended to be a history lesson, but it will provide some context for how we got to where we are and what this says about where biomedical research and healthcare seems to be heading. I will further provide insight into how various innovations in computation, policy, and industry have pushed the field forward and where recently established programs to expand AI activities, such as AIM-AHEAD and Bridge2AI, may push the biomedical research community over the next decade. To ground this presentation, I will provide examples of how AI and data science more generally have driven activities at the All of Us Research Program and the Vanderbilt Health Data Science Center.

Short Bio: Bradley Malin is the Vice Chair for Research in the Department of Biomedical Informatics at Vanderbilt University Medical Center and is the Accenture Professor of Biomedical Informatics, Biostatistics, and Computer Science at Vanderbilt University. He founded and co-directs the Vanderbilt Health Data Science Center, as well as the Center for Genetic Privacy and Identity in Community Settings (GetPreCiSe), the latter of which is an NIH Center of Excellence in Ethical, Legal, and Social Implications Research. Since 2007, he has chaired the Committee on Access, Privacy, and Security (CAPS) for the NIH-sponsored All of Us Research Program and, in 2021, he became one of the founding PIs of the NIH Artificial Intelligence/Machine Learning Consortium to Advance Health Equity and Researcher Diversity (AIM-AHEAD). He serves on various governmental advisory bodies, including the Board of Scientific Counselors of the National Center for Health Statistics (NCHS) of the U.S. Centers for Disease Control and Medicine (CDC). He was honored as a Presidential Early Career Award for Scientists and Engineers (PECASE) and is an elected member of the National Academy of Medicine (NAM), the American College of Medical Informatics (ACMI), the American Institute for Medical and Biological Engineering (AIMBE), and the International Academy of Health Sciences Informatics (IAHSI) . He received a B.S. in Biological Sciences, M.S. in Machine Learning, M.Phil. in Public Policy and Management, and Ph.D. in Computer Science, all from Carnegie Mellon University.

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Lecture / Discussion Fri, 06 May 2022 12:03:12 -0400 2022-06-03T10:00:00-04:00 2022-06-03T11:00:00-04:00 Off Campus Location Omenn Lecture Lecture / Discussion Bradley Malin, PhD
7th Annual Gilbert S. Omenn, MD, PhD Lecture (June 3, 2022 10:00am) https://events.umich.edu/event/95013 95013-21789263@events.umich.edu Event Begins: Friday, June 3, 2022 10:00am
Location: Off Campus Location
Organized By: Omenn Lecture

Talk Title: Biomedical Data Science: The Hope, Hype, and Promise

Abstract: Data science was introduced as a “new” profession in the early 1960s, yet the Office of Data Science Strategy at the National Institutes of Health (NIH) was not established until 2018. Artificial intelligence (AI) traces its roots to at least the 1950s, with its first application as an expert system in medicine in the early 1970s. Yet, the NIH Working Group on AI was not established until 2018 as well, with their first report issued in 2019. This is not to say that these topics have been neglected over the past half-century, but it begs the question of why have they only now come to the forefront of biomedicine? We have seen multiple AI booms and busts, each of which has caused massive hype, dream crushing failures, and notable advancements (some more flashy than others) along the way. This talk is not intended to be a history lesson, but it will provide some context for how we got to where we are and what this says about where biomedical research and healthcare seems to be heading. I will further provide insight into how various innovations in computation, policy, and industry have pushed the field forward and where recently established programs to expand AI activities, such as AIM-AHEAD and Bridge2AI, may push the biomedical research community over the next decade. To ground this presentation, I will provide examples of how AI and data science more generally have driven activities at the All of Us Research Program and the Vanderbilt Health Data Science Center.

Short Bio: Bradley Malin is the Vice Chair for Research in the Department of Biomedical Informatics at Vanderbilt University Medical Center and is the Accenture Professor of Biomedical Informatics, Biostatistics, and Computer Science at Vanderbilt University. He founded and co-directs the Vanderbilt Health Data Science Center, as well as the Center for Genetic Privacy and Identity in Community Settings (GetPreCiSe), the latter of which is an NIH Center of Excellence in Ethical, Legal, and Social Implications Research. Since 2007, he has chaired the Committee on Access, Privacy, and Security (CAPS) for the NIH-sponsored All of Us Research Program and, in 2021, he became one of the founding PIs of the NIH Artificial Intelligence/Machine Learning Consortium to Advance Health Equity and Researcher Diversity (AIM-AHEAD). He serves on various governmental advisory bodies, including the Board of Scientific Counselors of the National Center for Health Statistics (NCHS) of the U.S. Centers for Disease Control and Medicine (CDC). He was honored as a Presidential Early Career Award for Scientists and Engineers (PECASE) and is an elected member of the National Academy of Medicine (NAM), the American College of Medical Informatics (ACMI), the American Institute for Medical and Biological Engineering (AIMBE), and the International Academy of Health Sciences Informatics (IAHSI) . He received a B.S. in Biological Sciences, M.S. in Machine Learning, M.Phil. in Public Policy and Management, and Ph.D. in Computer Science, all from Carnegie Mellon University.

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Lecture / Discussion Fri, 06 May 2022 12:03:12 -0400 2022-06-03T10:00:00-04:00 2022-06-03T11:00:00-04:00 Off Campus Location Omenn Lecture Lecture / Discussion Bradley Malin, PhD
“Genetic regulation of epithelial homeostasis and injury” (June 7, 2022 4:00pm) https://events.umich.edu/event/95318 95318-21789154@events.umich.edu Event Begins: Tuesday, June 7, 2022 4:00pm
Location:
Organized By: Center for Cell Plasticity and Organ Design

The NIH T32 Training Program in Organogenesis trainees are please to present a Special Series, "Building and Rebuilding: Regulation of Cell Signaling in Development and Regeneration," featuring guest speaker, Adam D. Gracz, PhD.

Dr. Gracz is an Assistant Professor of Medicine-Division of Digestive Disease at Emory University.

The talk is entitled, “Genetic regulation of epithelial homeostasis
and injury.”

Trainee Host
Megan Radyk, PhD-Lyssiotis & Shah Labs

For more information email: Organogenesis@umich.edu

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Lecture / Discussion Thu, 26 May 2022 10:58:57 -0400 2022-06-07T16:00:00-04:00 2022-06-07T17:00:00-04:00 Center for Cell Plasticity and Organ Design Lecture / Discussion Gracz flyer
BME PhD Defense: Feiran Li (June 13, 2022 12:00pm) https://events.umich.edu/event/95461 95461-21789961@events.umich.edu Event Begins: Monday, June 13, 2022 12:00pm
Location: North Campus Research Complex Building 520
Organized By: Biomedical Engineering

Cell-based therapies are emerging for Type I diabetes mellitus (T1D), an autoimmune disease characterized by the destruction of insulin producing pancreatic β-cells, as a means to provide long term restoration of glycemic control. The limited supply of donor islets has motivated research into methods for differentiating pancreatic β-cells from renewable pluripotent stem cells such as human pluripotent stem cells (hPSCs). Biomaterial scaffolds maintain the integrity of cell-to-cell and cell-to-matrix connections by avoiding the disruption of the cell niche during handling. This dissertation addresses three key questions with respect to cell therapy and immunomodulation for T1D, including culture system on porous PLG scaffold, functionalized scaffold for improved cell viability and maturation, and immunomodulation with the membrane coated nanoparticles (MCNPs).

Culture on porous biomaterial scaffolds of hPSCs was investigated at multiple stages of differentiation between Stage 0 and 6 for improved differentiation. Scaffolds are biomaterial devices that could provide chemical and physical cues to control the microenvironment and subsequently alter cellular behavior by facilitating cell-cell interactions. The culture of cells on the scaffolds was found to support maturation of SC derived beta cells depending on the stage of seeding. Suspension cultured-pancreatic progenitors seeded onto scaffolds for stage 5 culture (pancreatic endocrine development), demonstrated enhanced expression for many maturation genes compared to cells that remained in suspension culture through the end of stage 6. This study showcased the scaffold culture as a promising platform for maturation that allows cells to develop a niche and may allow for direct transplantation without manipulating cells.

Early engraftment and development of β-cells post transplantation are a major limitation for stem cell derived beta cells due in part to their being immature. The survival and development of hPSC-derived β-cells seeded onto PLG microporous scaffolds were investigated within the initial 2 weeks post transplantation. Early inflammatory events induced by the biomaterial and transplanted cells heavily affected hPSC-derived β-cell engraftment due to the innate immune response. The inflammation includes the production of soluble mediators, inflammatory cytokines and the recruitment of innate cells at the graft site, hindering early graft engraftment and in-vivo hPSC-derived β-cell maturation. The PLG-based biodegradable scaffold chemically linked with a novel form of FasL chimeric with streptavidin, SA-FasL, was applied to create an immunoprivileged transplant site by modulating the local inflammatory microenvironment. The β-cell viability and differentiation were found improved at the SA-FasL induced immunoprivileged site together with a suppressed inflammatory reaction.

Life-long systemic immune suppression due to allogenic graft/cell transplant also limits the translation of cell therapies for T1D. We investigated the design of membrane-coated nanoparticles (MCNPs), with membranes derived from bone marrow-derived dendritic cells and coated onto poly(lactic-co-glycolic acid) (PLGA) nanoparticle cores, to directly interact with both naïve and activated T cells. Mechanistic studies revealed that the developed MCNPs have the capability to communicate with allogenic T cells by modulating the cytokine secretion levels similar to professional antigen presenting cells. Furthermore, the MCNPs can be engineered pre- and post-fabrication for upregulated surface molecules or varied antigen binding and can be functionalized by biotinylation for a wider range of protein loading.

Overall, this dissertation discussed optimization and early immunomodulation of the biomaterial culturing system for hPSC-derived β cells, and development of tunable MCNPs for direct T cell communication.

Date: Monday, June 13, 2022
Time: 12:00 PM
Location: NCRC Building 520 Room 1122 and Zoom (https://umich.zoom.us/j/93840656651)
Chair: Dr. Lonnie Shea

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Lecture / Discussion Tue, 07 Jun 2022 09:22:42 -0400 2022-06-13T12:00:00-04:00 2022-06-13T13:00:00-04:00 North Campus Research Complex Building 520 Biomedical Engineering Lecture / Discussion BME Defense
Well-Being & Academic Success Celebration Ceremony (June 15, 2022 6:00pm) https://events.umich.edu/event/87838 87838-21647064@events.umich.edu Event Begins: Wednesday, June 15, 2022 6:00pm
Location: Off Campus Location
Organized By: Michigan Medicine Wellness Office

Come celebrate yourself and your commitment to self-care.


Register to receive zoom link: https://sessions.studentlife.umich.edu/track/event/session/45702

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Well-being Mon, 04 Oct 2021 11:55:07 -0400 2022-06-15T18:00:00-04:00 2022-06-15T19:00:00-04:00 Off Campus Location Michigan Medicine Wellness Office Well-being Wellness Office Logo
Understanding and engineering microbes for solving complex problems in biology and medicine (June 16, 2022 3:30pm) https://events.umich.edu/event/95526 95526-21790074@events.umich.edu Event Begins: Thursday, June 16, 2022 3:30pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: Biomedical Engineering

Abstract:

The microbiome represents an exciting frontier in medicine, and early successes in the field have demonstrated the dynamic interactions among individual microbial species and highlighted the crosstalk between microbiota and their hosts at the mucosal interface.  The Li research group in the Department of Bioengineering at Northeastern University focuses on the development of molecular and live cell-based therapeutics, with a major emphasis on harnessing innovative synthetic biology and drug delivery approaches for improving human health in a sustainable manner. In this talk, I will present our work from the past three years in interrogating and manipulating commensal bacteria and probiotics as therapeutic platforms to promote human health.

Bio:

Jiahe Li obtained his PhD in Biomedical Engineering at Cornell University in 2015, where he leveraged synthetic biology approaches and cell biology to engineer bacteria and platelets as platforms for treating metastatic cancer. Later, he pursued his postdoctoral training at the Koch Institute for Integrative Cancer Research at MIT from 2015-2018, where he gained complementary expertise in polymer science and gene delivery. He started a tenure-track faculty position in the Department of Bioengineering at Northeastern University in 2019, and his current research is supported by NIH, DoD, and various biotech companies.

Zoom Link: https://umich.zoom.us/j/97247012805

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Lecture / Discussion Thu, 09 Jun 2022 15:34:33 -0400 2022-06-16T15:30:00-04:00 2022-06-16T16:30:00-04:00 Lurie Biomedical Engineering (formerly ATL) Biomedical Engineering Lecture / Discussion BME Seminar
LHS Collaboratory (June 21, 2022 12:00pm) https://events.umich.edu/event/95245 95245-21789057@events.umich.edu Event Begins: Tuesday, June 21, 2022 12:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

"Restructuring health systems for learning: Building equity into the Learning Health System"
Learn more about ELSI-LHS (Ethical, Legal, and Social Implications of Learning Health Systems). The session will be moderated by, Jody E. Platt, MPH, PhD, Assistant Professor of Learning Health Sciences.

Speaker:
Lauren A. Taylor, PhD, MDiv, MPH
Assistant Professor
Department of Population Health
Division of Medical Ethics
NYU Grossman School of Medicine

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Lecture / Discussion Wed, 25 May 2022 00:20:49 -0400 2022-06-21T12:00:00-04:00 2022-06-21T13:00:00-04:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion LHS Collaboratory logo
Health Professionals and Politics (June 21, 2022 5:00pm) https://events.umich.edu/event/95521 95521-21790034@events.umich.edu Event Begins: Tuesday, June 21, 2022 5:00pm
Location: Medical Science Research Building 1
Organized By: NextGen Med

Join us for a presentation and Q/A session with Dr. Abdul El-Sayed who will be discussing the role health professionals can take to positively shape our healthcare system and future as a nation.

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Presentation Thu, 09 Jun 2022 13:47:44 -0400 2022-06-21T17:00:00-04:00 2022-06-21T18:30:00-04:00 Medical Science Research Building 1 NextGen Med Presentation Dr. El-Sayed
Clinical Simulation Center Lunch and Learn (July 20, 2022 12:00pm) https://events.umich.edu/event/95923 95923-21791439@events.umich.edu Event Begins: Wednesday, July 20, 2022 12:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Dr. Owens' team helped to develop the Stanford Virtual Heart (SVH), a virtual reality curriculum to teach normal cardiac anatomy as well as 6 basic congenital heart defects (CHDs). Multi-center prospective studies have shown that the SVH improves pediatric residents' as well as medical students' knowledge on CHDs. Future initiatives include developing a virtual reality curriculum for more complex lesions (such as hypoplastic left heart syndrome).

Join her presentation and subsequent discussion on Zoom.

Join Zoom Meeting:
https://umich.zoom.us/j/98458273274?pwd=MXJTTWdFaURHa3d4NE5XNjd2YmVMUT09

Meeting ID: 984 5827 3274
Passcode: 1111

One tap mobile
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Dial by your location
+1 646 876 9923
Meeting ID: 984 5827 3274
Passcode: 1111
Find your local number: https://umich.zoom.us/u/ad8qCm9Q22

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Presentation Thu, 07 Jul 2022 15:11:10 -0400 2022-07-20T12:00:00-04:00 2022-07-20T13:00:00-04:00 Off Campus Location Department of Learning Health Sciences Presentation Picture source: https://www.stanfordchildrens.org/en/innovation/virtual-reality/stanford-virtual-heart
BioArtography Booth at the Ann Arbor Art Fair (July 21, 2022 10:00am) https://events.umich.edu/event/96071 96071-21791886@events.umich.edu Event Begins: Thursday, July 21, 2022 10:00am
Location:
Organized By: BioArtography

BioArtography will be in South University Booth SU1109 (Between E. Univ. and Church) the Ann Arbor Art Fair! 13 spectacular new images for 2022 will be making their debut!

Every day at the University of Michigan, scientists from many fields work together to study organism development, function and disease. While the goal of these studies is to design new and effective ways to treat disease and provide better understanding of ourselves as well as the world around us, many are also taking the time to share the beauty of their work with others through a program called BioArtography. In the course of research, scientists use special stains to add color to the otherwise transparent tissues. Microscopes then allow detailed observation of the tiny, colorful biological structures revealed in these images. This results in a fascinating combination of art and science that U-M researchers are capturing in pictures taken through microscopes and turning into artworks that would look beautiful on any wall.

The goal of these studies is to design new and effective ways to treat disease and provide better understanding of ourselves as well as the world that surrounds us. Proceeds from the sale of this work help support the training of our next generation of researchers. Past BioArtography sales have raised enough money to send more than 100 graduate students and postdoctoral fellows to scientific conferences, where they can present their work to other scientists and make connections that can help them launch their careers in research and industry.

Throughout the year BioArtography images (a collection of over 250) can be viewed and ordered online at www.bioartography.com

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Exhibition Mon, 18 Jul 2022 12:08:38 -0400 2022-07-21T10:00:00-04:00 2022-07-21T21:00:00-04:00 BioArtography Exhibition BioArtography at the Ann Arbor Art Fair
BioArtography Booth at the Ann Arbor Art Fair (July 22, 2022 10:00am) https://events.umich.edu/event/96071 96071-21791887@events.umich.edu Event Begins: Friday, July 22, 2022 10:00am
Location:
Organized By: BioArtography

BioArtography will be in South University Booth SU1109 (Between E. Univ. and Church) the Ann Arbor Art Fair! 13 spectacular new images for 2022 will be making their debut!

Every day at the University of Michigan, scientists from many fields work together to study organism development, function and disease. While the goal of these studies is to design new and effective ways to treat disease and provide better understanding of ourselves as well as the world around us, many are also taking the time to share the beauty of their work with others through a program called BioArtography. In the course of research, scientists use special stains to add color to the otherwise transparent tissues. Microscopes then allow detailed observation of the tiny, colorful biological structures revealed in these images. This results in a fascinating combination of art and science that U-M researchers are capturing in pictures taken through microscopes and turning into artworks that would look beautiful on any wall.

The goal of these studies is to design new and effective ways to treat disease and provide better understanding of ourselves as well as the world that surrounds us. Proceeds from the sale of this work help support the training of our next generation of researchers. Past BioArtography sales have raised enough money to send more than 100 graduate students and postdoctoral fellows to scientific conferences, where they can present their work to other scientists and make connections that can help them launch their careers in research and industry.

Throughout the year BioArtography images (a collection of over 250) can be viewed and ordered online at www.bioartography.com

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Exhibition Mon, 18 Jul 2022 12:08:38 -0400 2022-07-22T10:00:00-04:00 2022-07-22T21:00:00-04:00 BioArtography Exhibition BioArtography at the Ann Arbor Art Fair
BioArtography Booth at the Ann Arbor Art Fair (July 23, 2022 10:00am) https://events.umich.edu/event/96071 96071-21791888@events.umich.edu Event Begins: Saturday, July 23, 2022 10:00am
Location:
Organized By: BioArtography

BioArtography will be in South University Booth SU1109 (Between E. Univ. and Church) the Ann Arbor Art Fair! 13 spectacular new images for 2022 will be making their debut!

Every day at the University of Michigan, scientists from many fields work together to study organism development, function and disease. While the goal of these studies is to design new and effective ways to treat disease and provide better understanding of ourselves as well as the world around us, many are also taking the time to share the beauty of their work with others through a program called BioArtography. In the course of research, scientists use special stains to add color to the otherwise transparent tissues. Microscopes then allow detailed observation of the tiny, colorful biological structures revealed in these images. This results in a fascinating combination of art and science that U-M researchers are capturing in pictures taken through microscopes and turning into artworks that would look beautiful on any wall.

The goal of these studies is to design new and effective ways to treat disease and provide better understanding of ourselves as well as the world that surrounds us. Proceeds from the sale of this work help support the training of our next generation of researchers. Past BioArtography sales have raised enough money to send more than 100 graduate students and postdoctoral fellows to scientific conferences, where they can present their work to other scientists and make connections that can help them launch their careers in research and industry.

Throughout the year BioArtography images (a collection of over 250) can be viewed and ordered online at www.bioartography.com

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Exhibition Mon, 18 Jul 2022 12:08:38 -0400 2022-07-23T10:00:00-04:00 2022-07-23T20:00:00-04:00 BioArtography Exhibition BioArtography at the Ann Arbor Art Fair
Discovery and Development of Agonist Antibodies for T Cell Receptors (July 29, 2022 10:00am) https://events.umich.edu/event/96254 96254-21792188@events.umich.edu Event Begins: Friday, July 29, 2022 10:00am
Location: Off Campus Location
Organized By: Biomedical Engineering

Agonist antibodies that activate co-stimulatory immune receptors, such as the tumor necrosis factor (TNF) receptors OX40 and CD137, are an important class of emerging therapeutics due to their ability to regulate immune cell activity. Despite their promise, there are no approved agonist antibodies for treating cancer as demonstrated by previous unsuccessful clinical trials. Although multiple factors are responsible for poor clinical efficacy, one major bottleneck is the reliance on FcγR-mediated crosslinking for sufficient receptor activation. This is inherently problematic because FcγR expression varies greatly on different immune cells, leading to a wide range of receptor agonism. Emerging research suggests that antibodies engaging two different epitopes on the same immune receptor mediate receptor superclustering and enable robust antibody agonism without extrinsic Fc crosslinking. However, there are no systematic methods for identifying such biepitopic (also known as biparatopic) agonist antibodies. Therefore, the objective of this research work is to develop facile methods for reliably identifying biepitopic antibodies to activate immune receptors for immunotherapeutic applications.

Biepitopic antibodies have been shown to mediate potent receptor activation for a variety of immune receptors. Traditionally, the generation of these antibodies requires key steps including animal immunization, epitope binning to identify unique antibody pairs, and combining antibody pairs to engineer biepitopic antibodies. While this approach has been used to successfully discover biepitopic antibodies, it suffers from key limitations. Notably, animal immunization and subsequent antibody isolation is an arduous and unpredictable process. Even when successful clones are discovered from these processes, further epitope binning experiments are needed to select antibody pairs to discover potent immune therapeutics. To overcome these limitations, we developed an antibody screening strategy that greatly simplifies the discovery of biepitopic antibodies. Our approach eliminates the need for animal immunization by using existing, off-the-shelf IgG antibodies specific to the target receptor. Next, we perform in vitro selections by blocking the receptor epitope of the existing antibody and conducting subsequent sorts to identify single-chain antibodies with orthogonal binding domains. Thus far, our work has shown that the antibody screening strategy can be used to discover antibodies for a variety of TNF receptors including OX40 and CD137.

Given that receptor clustering of three or more receptors is critical for activating TNF receptors, we first generated biepitopic tetravalent OX40 antibodies by attaching novel single-chain antibodies to the C-termini of the light chain of existing clinical-stage antibodies. These tetravalent biepitopic antibodies showed remarkable T cell proliferation and cytokine secretion for biepitopic antibodies compared to their monoepitopic counterparts. Next, we sought to improve the additional clinical-stage OX40 IgGs engineered as biepitopic antibodies to show the generality of our findings that biepitopic antibodies can mediate superior and FcγR-independent activities. Beyond OX40 IgGs, we also show that biepitopic antibodies can be used to mediate superior T cell proliferation for other TNF receptors including CD137. Looking forward, we anticipate that these research advancements will accelerate the discovery and development of the next generation of immune therapeutics.

Date: Friday, July 29, 2022
Time: 10:00 AM
Zoom: https://umich.zoom.us/j/5163583658
Co-Chairs: Professors Peter Tessier and Lonnie Shea

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Lecture / Discussion Tue, 26 Jul 2022 13:09:39 -0400 2022-07-29T10:00:00-04:00 2022-07-29T11:00:00-04:00 Off Campus Location Biomedical Engineering Lecture / Discussion BME Ph.D. Defense
Michigan Marrow Donor Dash (July 31, 2022 9:00am) https://events.umich.edu/event/86426 86426-21788726@events.umich.edu Event Begins: Sunday, July 31, 2022 9:00am
Location: Off Campus Location
Organized By: Wolverines for Life

Register for our second annual Michigan Marrow Donor Day Dash! We're excited to meet on July 31st at Olson Park for a 3k walk and picnic. Attendees are encouraged to bring their friends, family, and pets in support of bone marrow donation. While you're there, join the bone marrow registry, learn more about Wolverines for Life and our partners, grab some giveaways, jam out with the DJ, and celebrate donation!

Michigan Medicine employees and visitors can choose to complete their walk virtually on an established route around the hospital grounds. Keep an eye out for signs posted a week prior to the in-person event event. Details will be emailed to registered attendees.

Registration: $30 (Discounts available for students, teams, and children.)

Proceeds will go towards Be the Match and the Michigan Medicine Bone Marrow Transplant Department.



All participants will receive a FREE Wolverines for Life and Be the Match t-shirt.

Register here: https://wesavelives.bethematch.org/index.cfm?fuseaction=donorDrive.event&eventID=621



We’ll also need a small team of volunteers to help set-up, tear-down, and staffing tables at the event.

Click here to volunteer: https://www.signupgenius.com/go/20f0e4fa8ac2fa0fb6-michigan1

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Exercise / Fitness Tue, 17 May 2022 16:33:57 -0400 2022-07-31T09:00:00-04:00 2022-07-31T13:00:00-04:00 Off Campus Location Wolverines for Life Exercise / Fitness Donor Dash Flyer
Hierarchical motion modeling of abdominal motions for radiation therapy (August 9, 2022 10:00am) https://events.umich.edu/event/96536 96536-21792631@events.umich.edu Event Begins: Tuesday, August 9, 2022 10:00am
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: Biomedical Engineering

Abstract:

Human abdominal organs are subject to a variety of physiological forces that superimpose their effects to influence local motion and configuration. Motions include breathing, gastric contraction, and other types of less periodic slow configuration changes. Breathing motion has been extensively studied and well characterized; however, gastric contraction and slow configuration motion have been rarely investigated. By using a golden angle stack-of-star radial sampling magnetic resonance image (MRI) sequence, we constructed a hierarchical motion model that characterizes each of these three motions, as well as their combined effects. Breathing motion is extracted and corrected as the first step, following by reconstruction of gastric motion and slow configuration changes. The model shows non-neglectable geometric displacements raised by all three motion modes. These motions, if not managed properly during radiation therapy, may potentially result in overdose to normal tissue or underdosage to the tumor target. Magnetic resonance guided radiotherapy (MRgRT) systems have been developed which have the technical capability to address these complex motions, but to date their primary applications have been relegated to management of breathing motion. In this dissertation, we proposed a gastric motion prediction framework to allow real-time management of contractile motion during MRgRT taking advantage of the intra-scan stability of gastric contraction motion observed in patients under standard pre-session eating restrictions. The framework was able to achieve submillimeter prediction error with a sufficient future prediction time to overcome the latency introduced by the image sampling reconstruction, motion assessment and treatment interruption or modification on MR-guided linear accelerators. Motions and deformations during radiation treatment present a challenge to precisely and accurately measure the radiation dose delivered to abdominal organs. A dose accumulation tool, developed based on the hierarchical motion model, was built to estimate dose distributions with abdominal motions. The tool demonstrates potential deviations of dose due to motion and shows exceeding of dose constraints in certain cases. It could support offline adaptation or help record delivered dose more accurately than stationary images used for daily patient positioning and/or online adaptation of treatment plans. The motion model is also currently supporting other clinical applications, including providing improved image quality reconstructions from free-breathing scans for improvement of accuracy of perfusion as well as liver functional maps. In the future, the model can be further utilized in other fields including radiology or gastroenterology.  

Room: LBME 2185 / Zoom Link: https://umich.zoom.us/j/93620134849 Meeting ID: 936 2013 4849 Passcode: 268890

Committee Chair(s): Dr. James Balter and Dr. Rojano Kashani

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Lecture / Discussion Fri, 05 Aug 2022 10:05:16 -0400 2022-08-09T10:00:00-04:00 2022-08-09T11:00:00-04:00 Lurie Biomedical Engineering (formerly ATL) Biomedical Engineering Lecture / Discussion BME Defense
Effects of Electric Stimulation on Physiology and Anatomy of the Visual Pathway (August 10, 2022 12:00pm) https://events.umich.edu/event/96539 96539-21792637@events.umich.edu Event Begins: Wednesday, August 10, 2022 12:00pm
Location:
Organized By: Biomedical Engineering

Abstract:
Retinal degenerative diseases that progressively lead to severe blindness impact the affected individual’s quality-of-life. Visual prosthesis technology aims to provide an individual a potential means of obtaining visual information lost to them by blindness. Since the proof-of-concept success in 1968 of a device implanted in a human, visual prostheses have had sustained academic research and commercial interest. However, commercial failure of two retinal prosthesis device has raised concerns for the visual prosthesis field. To learn from this experience, research in this dissertation is aimed at understanding the impact of electric stimulation on the target neural tissue and investigating technology for a visual cortex prosthesis, which can reach a larger patient population (compared to a retinal prosthesis).

My first set of experiments assessed, in an animal model of retinal degeneration, the condition of the brain and its ability to receive artificial vision information. Retinitis Pigmentosa has been proven to impact the human brain. My study investigated the extent to which this was replicated in a rat animal model of a single genetic mutation of Retinitis Pigmentosa. The P23H-1 rat was investigated with electrophysiology and immunohistochemistry to understand the brain’s function and structural condition. The rat brain’s response to light and electric stimulation was investigated, and the change of visually evoked responses and maintenance of electrically evoked responses was observed. Histology images show a relatively stable macrostructure of the blind rat brain.

I also performed retinal and cortical implant procedures to test newly developed visual prosthesis technology to enable investigations into researching neural change occurring from blindness and electric stimulation. A retinal device with Parylene-C as its main component was tested and its feasibility in the small eye of a rat animal model was investigated. The device can survive 4-weeks of implantation and is stable within the eye. In support of the development of a novel cortical visual prosthesis device that fits the need of blind individuals, I used a small animal model first to prove the efficacy and safety of a novel neurostimulation electrode. The device, named StiMote, is in preclinical development. I worked to characterize the full ability of the neural interface, High-Density Carbon Fibers with electrodeposited Platinum-Iridium. The ability of PtIr-HDCF as a recording and stimulation neural interface device was verified using electrochemical measurements before, during, and after a long-duration 7-hour electric stimulation session that simulates a full day of device use.

PtIr-HDCF as a neural interface device was verified by my previous work and its improvement in reducing neuroinflammatory response compared to other microelectrode array archetypes has been previously researched. As a result, PtIr-HDCF can be used as a device to monitor the brain and can better extract the effect of electric stimulation on the brain alone. I recorded neural electrophysiology to verify the rat brain’s sensitivity to stimuli before and after 7-hour stimulation. To supplement the already existing neural implant and electric stimulation inflammation data, Spatial Transcriptomics as a novel method to define electric stimulation safety was performed. Spatial Transcriptomics showed that PtIr-HDCF, when compared to a conventional microwire array, performs better in sustaining neural health by reducing neuroinflammation and eliciting mRNA upregulation of neurotrophic factors.

Findings of this project can be used to better inform future investigations into brain electrophysiology and transcriptomics projects aimed to understand the neural change from blindness and electric stimulation.

Committee Chair(s): Dr. James Weiland

Location: 1501 Auditorium, NCRC Bldg 32 & https://umich.zoom.us/j/91500987159?pwd=RWIvQkZVT2FHZjQ2S1BBS2k0ck1SUT09

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Lecture / Discussion Fri, 05 Aug 2022 10:32:21 -0400 2022-08-10T12:00:00-04:00 2022-08-10T13:00:00-04:00 Biomedical Engineering Lecture / Discussion BME Defense
Artscapade! (August 26, 2022 6:00pm) https://events.umich.edu/event/97379 97379-21794495@events.umich.edu Event Begins: Friday, August 26, 2022 6:00pm
Location: Museum of Art
Organized By: University of Michigan Museum of Art (UMMA)

.

UMMA and Arts at Michigan celebrate Welcome Week by introducing new University of Michigan students to the Museum of Art for an evening of  live music, performances, dance, poetry, film, games, prize raffle, and a variety of art-making activities.  During the event, students will  have the opportunity to become familiar with the Museum and everything it has to offer, as well as experience the wide array of possibilities for arts participation across campus. 

All students, faculty and staff on the Ann Arbor (including Michigan Medicine), Dearborn and Flint campuses are required to be vaccinated against COVID-19 and submit their vaccination information by August 30. In addition, masks will be required in all indoor spaces and social distancing guidelines will be in place.

Student programming at UMMA is generously supported by the University of Michigan Credit Union Arts Adventures Program, UMMA's Lead Sponsor for Student and Family Engagement.

 

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Presentation Sat, 27 Aug 2022 00:16:16 -0400 2022-08-26T18:00:00-04:00 2022-08-26T21:00:00-04:00 Museum of Art University of Michigan Museum of Art (UMMA) Presentation Museum of Art
Biomaterials and Synthetic Biology for Monitoring Immune Function (September 1, 2022 4:30pm) https://events.umich.edu/event/97432 97432-21794558@events.umich.edu Event Begins: Thursday, September 1, 2022 4:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Abstract:
Although the prevalence of autoimmune diseases continues to grow, monitoring these conditions remains a challenge resulting in delayed diagnosis, ineffective treatment, and ultimately increased patient morbidity. The PRecision Immune MicroEnvironments (PRIME) Lab, seeks to address this challenge by combining biomaterials and synthetic biology to create a minimally invasive toolset for monitoring immune responses within tissues. Our work on biomaterial-based immunological niches demonstrates that implantable materials enable the formation of an engineered tissue that can be biopsied to monitor multiple sclerosis (MS). These niches provide insights into the phenotype of immune cells that control disease activity, and can be used to monitor disease dynamics or to gauge the effectiveness of treatment. To move beyond biopsy, we are developing synthetic biology tools that enable detection of specific biomarkers of immune function. I will conclude my talk with a brief discussion of my planned research program that aims to leverage materials, immune engineering, and synthetic biology to build translatable tools for real-time monitoring of tissue immunity.

Bio:
Dr. Aaron Morris is an Assistant Professor in the Department of Biomedical Engineering at the University of Michigan, and runs the PRecision Immune MicroEnvironments Laboratory (PRIME Lab). Dr. Morris completed a B.S. in BME at Georgia Tech, followed by a Ph.D. in BME from Yale University. As a postdoc, Dr. Morris worked with Dr. Lonnie Shea at the University of Michigan to use biomaterials to interrogate the immune system during autoimmunity and with Dr. Joshua Leonard at Northwestern University to build synthetic, modular receptor systems for synthetic biology platforms. Dr. Morris’s work has been supported through a number of mechanisms including the NIH K99/R00, NSF GRFP, NIH T32, Michigan Life Sciences Institute Fellows program, and a Michigan Precision Health grant, and a TED Fellowship (check out his TED talk here if interested).

Zoom:
https://umich.zoom.us/j/91375430500

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Workshop / Seminar Thu, 01 Sep 2022 10:47:54 -0400 2022-09-01T16:30:00-04:00 2022-09-01T17:30:00-04:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar BME 500 Seminar
From molecules to development: biological timing and patterning (September 8, 2022 4:30pm) https://events.umich.edu/event/97913 97913-21795312@events.umich.edu Event Begins: Thursday, September 8, 2022 4:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Abstract:
Organisms from bacteria to humans employ complex biochemical or genetic oscillatory networks, termed biological clocks, to drive a wide variety of cellular and developmental processes for robust timing and patterning. Despite their complexity and diversity, many of these clocks share the same core architectures that are highly conserved from species to species, suggesting an essential role of network structures underlying clock functioning. The Yang lab, bridging biophysics and systems & synthetic biology, has integrated modeling with experiments in minimal cells and live embryos to elucidate universal physical mechanisms underlying the complex processes during development. In this talk, I will focus on our recent efforts in understanding the design and interaction of cellular clocks in cell cycles and embryonic developmental patterns. Computationally, we have identified network motifs, notably incoherent inputs, that universally enhance systems' robust performance. Experimentally, we developed a unique synthetic-cell system in microfluidic droplets to analyze circuits and functions of robustness and tunability. We also established single-cell assays of zebrafish embryos combined with biomechanics to analyze the role of energy and mechanical and biochemical signaling in spatiotemporal patterns.

Bio:
Qiong Yang received a Ph.D. in Physics from MIT in 2009 before joining the Department of Chemical and Systems Biology at Stanford University for postdoctoral research, supported by the Stanford Dean’s Postdoctoral Fellowship and a Damon Runyon Cancer Research Fellowship. She was appointed as an Assistant Professor in Biophysics at the University of Michigan in 2014 and was promoted to Associate Professor in 2022. Her research group is affiliated with the departments of Physics, Applied Physics, BME, Complex Systems, and Computational Medicine & Bioinformatics at UM. She has received awards including NSF CAREER, NIH MIRA, Sloan Fellowship, Elizabeth C. Crosby Award, and Class of 1923 Memorial Teaching Award.​​​​​​​

Zoom:
https://umich.zoom.us/j/91375430500

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Workshop / Seminar Thu, 01 Sep 2022 10:44:42 -0400 2022-09-08T16:30:00-04:00 2022-09-08T17:30:00-04:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar BME 500 Seminar
Alum Connection: Medicine and Beyond with Dr. Tyler Barrett (September 9, 2022 12:00pm) https://events.umich.edu/event/96846 96846-21794618@events.umich.edu Event Begins: Friday, September 9, 2022 12:00pm
Location: LSA Building
Organized By: LSA Opportunity Hub

Exploring the possibility of a career in medicine? LSA alum Dr. Tyler Barrett joins us to help you think through the decision process on applying to medical school, as well as alternative career paths one might consider. With a speciality in emergency services and opioid treatments, Dr. Barrett will share his experiences and provide insights that may inform your decision to pursue a career in medicine as a clinician, research scientist, administrator, or one of many other important professional roles. He will also share his tips for how best to translate your undergraduate experience onto paper for a future medical school application. If you’re looking for a medicine-adjacent career, Dr. Barrett will also offer expertise and learnings into the areas of administration, research, publishing, and private consulting.


About Dr. Tyler Barrett
Dr. Tyler W. Barrett serves as the executive medical director for emergency services and professor of emergency medicine at Vanderbilt University. Dr. Barrett’s clinical goals are optimizing efficient and appropriate patient care, quality improvement, opioid stewardship, opioid dependence treatment, multidisciplinary patient care pathways, and reimbursement related issues. His research goals are to improve the emergency department (ED) treatment of patients with opioid use disorder, increase use of non-opioid analgesia, management of venous thromboembolism, and risk stratification of ED patients with atrial fibrillation.

He co-chairs the Vanderbilt University Medical Center Controlled Substances Quality Oversight Committee and chairs the Vanderbilt Committee on Opioid Monitoring and Stewardship. He was supported as principal investigator by a NHLBI K23 award. Dr. Barrett is currently funded through federal and state grants related to opioid use disorder treatment and educating prescribers on optimal opioid stewardship. Dr. Barrett serves as an Emergency Medicine Team Physician for the Nashville Predators, served on the Nashville Youth Hockey League Board of Directors from 2014-2022, and is actively involved in promoting education about the dangers of opioids among student-athletes. He authored the USA Hockey Player Safety Program “Opioid Fact Check” and “E-cigarette “Vaping” Fact Check” educational materials.


You should attend this session if you are:
-An undergraduate U-M LSA student
-Interested in white coat medicine, and sub-specialities like emergency medicine or opioid treatments
-Thinking about applying to medical school after you graduate from LSA
-Looking for other career paths within healthcare and medicine like medical consulting


What you’ll gain by attending:
-Make a valuable connection with a successful LSA alum ready to help you navigate the medical school application process
-Get ideas for how to build a career in medicine outside of traditional white coat medicine
-Gain tips and tricks for building communities and networks past your LSA degree


RSVP NOW to be part of the conversation. This conversation is available in person and virtually. Please RSVP in the applicable link.

The Opportunity Hub aims to deliver inclusive and accessible experiences and welcomes all LSA students to participate. This event is on the 1st floor of a wheelchair accessible building which includes wheelchair-accessible restrooms on the 1st floor, a gender-inclusive and accessible restroom on the 1st floor, places to sit or stand during the event, and accessible parking options nearby on Maynard Street. The LSA Opportunity Hub can email materials ahead of time to virtual participants as well. To request other accommodations please contact Sairah Husain at sairah@umich.edu or 734-763-4674 so we can make arrangements.

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Workshop / Seminar Fri, 26 Aug 2022 11:47:16 -0400 2022-09-09T12:00:00-04:00 2022-09-09T13:00:00-04:00 LSA Building LSA Opportunity Hub Workshop / Seminar Dr. Tyler Barrett
DCM&B Tools and Technology Seminar (September 15, 2022 12:00pm) https://events.umich.edu/event/96847 96847-21793398@events.umich.edu Event Begins: Thursday, September 15, 2022 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

npore is a read realigner which recalculates each read's fine-grained alignment in order to more accurately align ''n-polymers'' such as homopolymers (n=1) and tandem repeats (2 ≤ n ≤ 6). In other words, given an input BAM, it adjusts each read's CIGAR string to more accurately model the most likely sequencing errors and actual variants. Traditional affine gap penalties are context-agnostic, and do not model the higher likelihood of INDELs in low-complexity regions (particularly n-polymers), leading to poor or inconsistent alignments. We find that npore improves pileup concordance across reads and results in slightly better variant calling performance.

Tool Link: https://github.com/TimD1/nPoRe

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

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Presentation Mon, 15 Aug 2022 10:35:55 -0400 2022-09-15T12:00:00-04:00 2022-09-15T13:00:00-04:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
Engineering Operational Transplant Tolerance via Biomaterials (September 15, 2022 4:30pm) https://events.umich.edu/event/97969 97969-21795406@events.umich.edu Event Begins: Thursday, September 15, 2022 4:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Abstract:
Organ and cell replacement therapies hold great promise for the treatment of multiple conditions, including autoimmune diseases such as type 1 diabetes. Restoration of endogenous insulin production, via cell delivery, has shown to be clinically successful in lowering complications and improving glucose sensing in patients. Yet, a widespread application has been hampered by the need for chronic immunosuppressive drugs to prevent strong inflammatory and immunological responses to the graft. Engineered materials offer a powerful approach for local, selective targeting of immune functionalities without compromising systemic immune function. In this talk, we will highlight engineered synthetic polymeric materials that can promote tissue integration and induce operational tolerance to cell therapies by generating a multifaced regulatory network.

Bio:
Prof Coronel is a Biological scholar and Assistant Professor of Biomedical Engineering at the University of Michigan. Her lab is centered on engineering biomaterials for perturbing and investigating immunological responses. Dr. Coronel received her BS degree in Biomedical Engineering from the University of Miami, and her Ph.D. in Biomedical Engineering from the University of Florida. She also obtained a certificate in Clinical Translational Research from Emory University Public Health School. She finished her postdoctoral fellowship at the Georgia Institute of Technology. Her work has been funded by JDRF, NIH, and the programmable materials initiative at the University of Michigan.

Zoom:
https://umich.zoom.us/j/91375430500

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Workshop / Seminar Thu, 01 Sep 2022 15:04:37 -0400 2022-09-15T16:30:00-04:00 2022-09-15T17:30:00-04:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar BME 500 Seminar
2nd Annual U-M Drug Discovery Symposium (September 21, 2022 9:00am) https://events.umich.edu/event/96651 96651-21793014@events.umich.edu Event Begins: Wednesday, September 21, 2022 9:00am
Location: Rackham Graduate School (Horace H.)
Organized By: Michigan Drug Discovery

Date: Wednesday, September 21, 2022
Time: 9:00am-4:00pm EST
Location: Rackham Building (915 E Washington)
~~This event is only open to current U-M students/trainees, staff, and faculty members~~

The second Annual U-M Drug Discovery Symposium aims to highlight success stories from the drug discovery community at Michigan, share best practices, and provide opportunities for networking.

Keynote Speaker:
Nicholas Meanwell, Ph.D.; Bristol Myers Squibb

Featured Speakers:
Mukesh Nyati, Ph.D.
Zaneta Nikolovska-Coleska, Ph.D.
James Shayman, M.D.
Peter Scott, Ph.D.



Questions/Comments please contact us at: drugdiscovery@umich.edu

Visit our event website for full details and schedule:
https://www.lsi.umich.edu/events/2022-09/annual-u-m-drug-discovery-symposium

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Conference / Symposium Mon, 19 Sep 2022 12:43:33 -0400 2022-09-21T09:00:00-04:00 2022-09-21T16:00:00-04:00 Rackham Graduate School (Horace H.) Michigan Drug Discovery Conference / Symposium Michigan Drug Discovery
DCMB Weekly Seminar (September 21, 2022 4:00pm) https://events.umich.edu/event/98815 98815-21797218@events.umich.edu Event Begins: Wednesday, September 21, 2022 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract:
The intersect between the life sciences (cells, tissues, organs) and engineered materials (polymers, biomacromolecules, semiconductors) is crucial for a wide range of medical and biotechnological applications. Hence, the precise control of biotic/abiotic interfaces has been one of the main obstacles of past decades. The Lahann Lab designs polymers for a range of different medical applications. In particular, we have developed a class of protein nanoparticles for targeting of glioblastoma. In addition, I will summarize our efforts related to sheet-like 3D organoid systems and will address recent advances with morphologically designed interfaces.

Research Interests:
Designer surfaces, advanced polymers, biomimetic materials, microfluidic devices, engineered microenvironments, nano-scale self-assembly.

Joerg Lahann’s research is broadly related to surface engineering with strong ties to biomedical engineering and nanotechnology. His research on reversibly switching surfaces was featured in an article in Science (J. Lahann, et al., A Reversibly Switching Surface, January 17, 2003, 299, 371-374.) These “smart surfaces” can reversibly switch properties in response to an external stimulus. To demonstrate these findings, a surface design was developed that can be changed from water-attracting to water-repelling with the application of a weak electric field. Designed as a switch, single-layered molecular-level machines are aligned on a surface using self-assembly and then are flipped between defined microscopic states. This type of surface design may offer a new paradigm for interfacial engineering as it amplifies reversible conformational transitions at a molecular level to macroscopic changes in surface properties without altering the chemical identity of the surface.

Joerg has also developed a novel class of polymers with potential for biomimetic and spatially directed surface engineering. This “reactive coating” technology uses chemical vapor deposition (CVD) polymerization to deposit a wide range of chemical signatures on various substrate materials. Its simplicity in providing chemically reactive groups and its applicability to three-dimensional geometries (e.g., for microfluidics) enables the exact tailoring of surface properties and the preparation of biologically relevant microenvironments. Reactive coatings are compatible with soft lithographic processes, allowing for patterning of proteins, DNA, cytokines, and mammalian cells.

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Lecture / Discussion Thu, 15 Sep 2022 11:36:52 -0400 2022-09-21T16:00:00-04:00 2022-09-21T17:00:00-04:00 Palmer Commons DCMB Seminar Series Lecture / Discussion (Protein pattern deposited on a polymer surface, artistic rendering, credit: Bahar Dadfar)
DCM&B Tools and Technology Seminar (September 22, 2022 12:00pm) https://events.umich.edu/event/96848 96848-21793400@events.umich.edu Event Begins: Thursday, September 22, 2022 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

This presentation will be given remotely, with the livestream available for group viewing in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

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Presentation Mon, 15 Aug 2022 10:42:50 -0400 2022-09-22T12:00:00-04:00 2022-09-22T13:00:00-04:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
LHS Collaboratory (September 22, 2022 12:00pm) https://events.umich.edu/event/96027 96027-21791723@events.umich.edu Event Begins: Thursday, September 22, 2022 12:00pm
Location: Palmer Commons
Organized By: Department of Learning Health Sciences

LHS Collaboratory Kickoff Poster Session Showcasing LHS Work at the University of Michigan

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Lecture / Discussion Tue, 12 Jul 2022 10:55:57 -0400 2022-09-22T12:00:00-04:00 2022-09-22T14:00:00-04:00 Palmer Commons Department of Learning Health Sciences Lecture / Discussion LHS Collaboratory logo
OHS Seminar Series Schedule (September 22, 2022 12:00pm) https://events.umich.edu/event/98131 98131-21795615@events.umich.edu Event Begins: Thursday, September 22, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

OHS Seminar Series Schedule Fall 2022 - Stay tuned for more updates!

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Presentation Tue, 06 Sep 2022 13:16:28 -0400 2022-09-22T12:00:00-04:00 2022-09-22T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Presentation OHS Seminar Series Schedule Fall 2022
Postdoc Appreciation Week – Special Presentations (September 22, 2022 12:00pm) https://events.umich.edu/event/98318 98318-21796492@events.umich.edu Event Begins: Thursday, September 22, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

Felicia Miranda, DDS, MS, PhD
Postdoctoral Fellow
Department of Orthodontics
University of Michigan School of Dentistry
Mentor: Lucia Cevidanes

Amanda Rodriguez, DDS, MS
Research Fellow & PiMA Program Assistant Director
Department of Periodontics and Oral Medicine
University of Michigan School of Dentistry
Mentors: Drs. Hsun-Liang Chan, DDS, MS and
Oliver Kripfgans, PhD

Hiroki Ueharu, Ph.D.
Department of Biologic & Materials Sciences and Prosthodontics, University of Michigan School of Dentistry
Mentor: Dr. Yuji Mishina

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Presentation Thu, 08 Sep 2022 12:20:48 -0400 2022-09-22T12:00:00-04:00 2022-09-22T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Presentation Postdoc Appreciation Week – Special Presentations
MAPS Mass Meeting! (September 22, 2022 9:00pm) https://events.umich.edu/event/98660 98660-21797035@events.umich.edu Event Begins: Thursday, September 22, 2022 9:00pm
Location: Mason Hall
Organized By: MAPS (Multicultural Association for Pre-health Students)

Come hear about the exciting plans for MAPS this year, meet the e-board, and engage with your fellow MAPS members!

The meeting is in 2306 Mason Hall on 9/22/22 from 9-10 pm.

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Meeting Tue, 13 Sep 2022 12:42:04 -0400 2022-09-22T21:00:00-04:00 2022-09-22T22:00:00-04:00 Mason Hall MAPS (Multicultural Association for Pre-health Students) Meeting event flyer
PBBs in Michigan: Empowering an Exposed Community (September 27, 2022 12:00pm) https://events.umich.edu/event/98897 98897-21797325@events.umich.edu Event Begins: Tuesday, September 27, 2022 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Featuring Bonnie Havlicek, RN (Co-Chair PBB Advisory Board) and Michele Marcus, PhD, MPH (Professor, Departments of Epidemiology, Environmental Health & Pediatrics, Schools of Public Health and Medicine, Emory University). Moderated by Amy Schulz, PhD (M-LEEaD CEC Core Leader, UM SPH).

Registration required for Zoom webinar https://bit.ly/3Le7hby

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Workshop / Seminar Fri, 16 Sep 2022 16:26:51 -0400 2022-09-27T12:00:00-04:00 2022-09-27T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Workshop / Seminar Residents & Researchers Tuesday Talks
OHS Seminar Series Schedule (September 29, 2022 12:00pm) https://events.umich.edu/event/98131 98131-21795616@events.umich.edu Event Begins: Thursday, September 29, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

OHS Seminar Series Schedule Fall 2022 - Stay tuned for more updates!

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Presentation Tue, 06 Sep 2022 13:16:28 -0400 2022-09-29T12:00:00-04:00 2022-09-29T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Presentation OHS Seminar Series Schedule Fall 2022
10th Anniversary Symposium & Celebration - Department of Computational Medicine & Bioinformatics (September 29, 2022 1:15pm) https://events.umich.edu/event/98793 98793-21797190@events.umich.edu Event Begins: Thursday, September 29, 2022 1:15pm
Location: Taubman Biomedical Science Research Building
Organized By: Omenn Lecture

On September 29, 2022, the University of Michigan Department of Computational Medicine and Bioinformatics (DCMB) will celebrate its 10th anniversary with a symposium and in-person gathering.

The event will be introduced by James Woolliscroft, M.D., Lyle C. Roll Professor of Medicine, and former dean of the Medical School. Department faculty members will present about their research, and two distinguished alumni –Erin Shellman, Ph.D., Head of Data at Gingko Bioworks, and Dan Rhodes, Ph.D., co-founder and CEO at Strata Oncology – will talk about their respective careers.

At 4:00 p.m., Holden Thorp, Ph.D., editor-in-chief, Science Family of Journals will give the 8th Annual G. Omenn Lecture: "Data Science and Medicine in the Age of Open Data, Open Code, and Open Access: From Protein Structure Prediction to COVID Origins"

A poster session will close the afternoon. For more information and registration, visit our website.

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Lecture / Discussion Wed, 14 Sep 2022 16:17:20 -0400 2022-09-29T13:15:00-04:00 2022-09-29T18:30:00-04:00 Taubman Biomedical Science Research Building Omenn Lecture Lecture / Discussion DCMB 10th Anniversary Symposium & Celebration
Re-imagining Ultrasound and Photoacoustic Imaging (September 29, 2022 4:30pm) https://events.umich.edu/event/99202 99202-21797699@events.umich.edu Event Begins: Thursday, September 29, 2022 4:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Abstract:
Paradigm shifts in technology are needed for next-generation ultrasound imaging. We introduce novel electrostrictive row-column array technology that promises improved 3D image quality and ultrafast imaging speeds. Moreover, these advances will lead to arrays of unprecedented size and novel form-factors such as endoscopic probes and wearable band-aids that will mitigate operator dependence and lead to longitudinal imaging opportunities. Our technology enables readout from every element of the 2D array using only row and column addressing, and is well-suited to volumetric photoacoustic imaging using pulsed laser excitation to image optical properties of tissues. Novel agents and genetically-encoded reporters will be introduced. Applications to brain imaging, cardiovascular medicine, small animal imaging will be discussed. Furthermore, a new non-contact all optical form of photoacoustic imaging will be discussed with applications to virtual histology of tissues.

Bio:
Roger Zemp earned his PhD from UC Davis in 2004 and after three years of postdoctoral work in the Laboratory of Prof. Lihong Wang, joined the Faculty in the Department of Electrical and Computer Engineering and Biomedical Engineering at the University of Alberta in 2007. He is a recognized international leader in the field of photoacoustic imaging and ultrasound imaging. He has co-founded two startup companies and maintains an active laboratory at the intersection of ultrasound, optics, micro-nano-fabrication, and in vivo imaging. ​​​​​​​

Zoom:
https://umich.zoom.us/j/91375430500

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Workshop / Seminar Thu, 22 Sep 2022 15:39:52 -0400 2022-09-29T16:30:00-04:00 2022-09-29T17:30:00-04:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar BME 500 Seminar
MGI 10th Anniversary Symposium (September 30, 2022 11:00am) https://events.umich.edu/event/97825 97825-21795204@events.umich.edu Event Begins: Friday, September 30, 2022 11:00am
Location: School of Public Health Bldg I and Crossroads and Tower
Organized By: Precision Health

At this free, in-person event, present and future users of Michigan Genomics Initiative (MGI) data can meet fellow MGI researchers and learn about the breadth and scope of ongoing MGI-supported research. We will present an overview of the available data resources to support your research, teaching, or grant writing, and explain how to access and use these resources. We will discuss our near-term and long-term goals and hope to get your input to shape our priorities.

Professor Goncalo Abecasis, D.Phil., will deliver a keynote address, and six MGI researchers will discuss their experience and highlight projects that benefited from MGI data.

Lunch will be provided, to give present and future MGI researchers, students, and postdocs the opportunity to network.

The one-day symposium will run from 11 am to 5 pm on Friday, September 30.

Attendance is free for registered participants.

Please RSVP By September 21.

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Conference / Symposium Fri, 02 Sep 2022 13:03:43 -0400 2022-09-30T11:00:00-04:00 2022-09-30T17:00:00-04:00 School of Public Health Bldg I and Crossroads and Tower Precision Health Conference / Symposium Keynote Speaker Goncalo Abecasis
The Interplay of Maternal Diet with Environmental Exposures in Pregnancy (October 4, 2022 12:00pm) https://events.umich.edu/event/99286 99286-21797811@events.umich.edu Event Begins: Tuesday, October 4, 2022 12:00pm
Location: Off Campus Location
Organized By: Michigan Lifestage Environmental Exposures and Disease Center

Registration required https://bit.ly/3Lzeh39

Rita Strakovsky, PhD, RD is an Assistant Professor of Maternal Nutrition and Toxicology in the Department of Food Science and Human Nutrition at Michigan State University.

Dr. Strakovsky's research focuses on various modifiable lifestyle and environmental factors that can be targeted to protect maternal and child health.

She has worked extensively in rodent pregnancy models to study the effects of maternal diet or exposure to environmental endocrine disrupting chemicals (EDCs) on the epigenetic regulation of energy metabolism in offspring. Driven by findings from these studies, my current research in human populations uses molecular epidemiology and biostatistics techniques to address several questions related to the health of mom and her developing fetus during pregnancy:
* Does exposure to endocrine disrupting chemicals in pregnancy impact maternal hormone levels and how does that impact fetal development via dysregulation of fetal fatty acid supply? (supported by K99/R00 award from NIEHS).
* Does exposure to phthalates in pregnancy impact maternal long-term cardiometabolic health, and does hormonal disruption mediate this relationship? (supported by R01 award from NIEHS).
* Do mixtures of dietary micronutrients impact length of gestation, and does diet quality or exposure to environmental chemicals modify this relationship? (supported by Administrative Supplement from NIH Office of Dietary Supplements).
* How does maternal obesity and adiposity impact biomarkers of reproductive endpoints in newborns, and does this differ in male vs. female babies? (supported by R03 award from NICHD).
* Is perinatal obesity associated with maternal mitochondrial epigenetic disruption and is that related to newborn weight or gestational age at birth? (supported by pilot grant from Michigan Environmental Influences on Child Health Outcomes cohort (ECHO))

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Lecture / Discussion Mon, 26 Sep 2022 11:17:41 -0400 2022-10-04T12:00:00-04:00 2022-10-04T12:50:00-04:00 Off Campus Location Michigan Lifestage Environmental Exposures and Disease Center Lecture / Discussion Oct 4 Interplay of Maternal Diet with Environmental Exposures in Pregnancy (Rita Strakovsky)
DCMB / CCMB Weekly Seminar (October 5, 2022 4:00pm) https://events.umich.edu/event/99751 99751-21798643@events.umich.edu Event Begins: Wednesday, October 5, 2022 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract:

Accurately predicting the onset of disease is a major challenge in clinical medicine because the genesis of diseases is generally a complex and dynamic process. Wearable sensor technologies provide an unprecedented opportunity to collect physiological data at orders of magnitude higher high time-resolution than conventional clinical practice. This provides unprecedented opportunities for investigating the dynamics of disease processes and may usher in a new era of real-time, personalized medicine. We have proposed the potential of real-time, continuously measured physiological data as a non-invasive, “digital biomarker” approach for detecting the earliest stages in transition to a disease state. In this talk, I will describe an example of our interdisciplinary team’s work on this topic that uses the early detection and possible prediction of febrile (i.e., fever-associated) adverse events in cancer events as an important application.

Clinical Interests
Prostate Cancer, General Oncology, Biomarkers in Oncology
Research Interests
• Biology of circulating, extracellular nucleic acids and translational applications
• Developing next generation approaches for early detection and monitoring of cancer
• Bioinformatics and computational biology, high-throughput sequencing
• New technologies to enable cancer detection and monitoring

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Lecture / Discussion Mon, 03 Oct 2022 15:21:48 -0400 2022-10-05T16:00:00-04:00 2022-10-05T17:00:00-04:00 Palmer Commons DCMB Seminar Series Lecture / Discussion Muneesh Tewari, MD, PhD
MS / PhD Open House (October 5, 2022 5:00pm) https://events.umich.edu/event/98232 98232-21795760@events.umich.edu Event Begins: Wednesday, October 5, 2022 5:00pm
Location: Palmer Commons
Organized By: U-M College of Pharmacy

Explore programs in drug discovery, delivery, and optimization.

Learn about our PhD programs in:
Medicinal Chemistry
Pharmaceutical Sciences
Clinical Pharmacy Translational Science

and our MS program in Integrated Pharmaceutical Sciences.

The event will include overview presentations regarding each program as well as a poster session featuring research presentations by our graduate students.

The MS/PhD Open House will be hosted in both in-person and virtual formats. We hope that you will make plans to attend!

If you have any questions, please contact Cherie Dotson at crdotson@umich.edu

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Reception / Open House Wed, 07 Sep 2022 14:17:55 -0400 2022-10-05T17:00:00-04:00 2022-10-05T19:00:00-04:00 Palmer Commons U-M College of Pharmacy Reception / Open House Text: advance your education.
DCM&B Tools and Technology Seminar (October 6, 2022 12:00pm) https://events.umich.edu/event/96850 96850-21793401@events.umich.edu Event Begins: Thursday, October 6, 2022 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

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Presentation Mon, 29 Aug 2022 13:40:58 -0400 2022-10-06T12:00:00-04:00 2022-10-06T13:00:00-04:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
Deciphering mechanisms of organismal phosphate regulation (October 6, 2022 12:00pm) https://events.umich.edu/event/98813 98813-21797217@events.umich.edu Event Begins: Thursday, October 6, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

EDUCATION
Massachusetts Institute of Technology, Cambridge, MA, USA
Doctor of Philosophy in Biology, September 2007-June 2014
University of Washington, Seattle, WA, USA
Honors Bachelor of Science in Neurobiology, September 2002-June 2006
POSITIONS AND ACADEMIC APPOINTMENTS
2021-Present Assistant Professor, University of Michigan School of Dentistry
2022-Present Faculty Member, Cellular and Molecular Biology Graduate Program, University of Michigan
2019-2021 Instructor in Medicine, Harvard Medical School, Massachusetts General Hospital, Boston, MA
2017-2019 Research Fellow, Endocrine Unit, Lab of Dr. Michael Mannstadt, MGH, Boston, MA
2015-2017 Postdoctoral Associate, Department of Molecular and Cellular Biology, Lab of Dr. Erin O’Shea,

Harvard University, Cambridge, MA

2007-2014 Graduate Research Fellow, Department of Biology, Lab of Dr. Laurie Boyer, MIT, Cambridge, MA
2006 Research Assistant, Department of Orthobiology, Lab of Dr. Mary Murphy,

National University of Ireland, Galway, Ireland

2005-2006 Undergraduate Research Fellow, Department of Genome Sciences, Lab of Dr. Leo Pallanck,

University of Washington, Seattle, WA

2003-2005 Undergraduate Research Fellow, Department of Biochemistry, Lab of Dr. Brian Kennedy,

University of Washington, Seattle, WA
ACADEMIC AND PROFESSIONAL HONORS
2021 University of Michigan Biological Sciences Scholar, Ann Arbor, MI
2019 Most Outstanding Poster, Bisphosphonates 50th Anniversary Meeting
2018 Endocrine Fellows Foundation Forum Travel Grant, Fellows Forum on Metabolic Bone Disease
2018 AIMM-ASBMR John Haddad Young Investigator Fellow
2017 American Society for Bone and Mineral Research Young Investigator Travel Grant Award,
2019 MIT Vertex Scholar, Cambridge, MA
2007 MIT Presidential Scholar
2006 University of Washington Herschel and Caryl Roman Undergraduate Science Scholar
2006 University of Washington Mary Gates Research Scholar
GRANTS AND FELLOWSHIPS
Current
NIH/NIAMS K99/R00 Pathway to Independence Award,
K99 period: August 2019-Sept 2021, R00 period: Feb 2022-Jan 2025
Title: Deciphering mechanisms of nitrogen-containing bisphosphonates, R00 funding: $249,000/year for 3 years

Previous
2018-2019 NIH T32 Training Grant Trainee, 2018-2019, Endocrinology Division, Massachusetts General Hospital
2017 American Cancer Society Postdoctoral Fellowship, 2017
PUBLICATIONS
Bondeson, D.P., Paolella, B.R., Asfaw, A., Rothberg, M., Skipper, T., Mesa, G., Gonzalez, A., Surface, L.E., Ito, K.,
Kazachkova, M., Colgan, W.N., Warren, A., Dempster, J., Krill-Burger, J., Ericsson, M., Tang, A., Fung, I., Chambers,
E.S., Abdusamad, M., Dumont, N., Doench, J.G., Piccioni, F., Root, D.R., Boehm, J., Hahn, W.C, Mannstadt, M.,
McFarland, J.M., Vazquez, F., Golub, T.R., (2022) Phosphate dysregulation via the XPR1:KIDINS220 protein
complex is a therapeutic vulnerability in ovarian cancer., Nature Cancer, 6:681-695

Surface,L.E., Burrow, D.T., Li, J., Park, J., Kumar, S., Lyu, C., Song, N., Yu, Z., Rajagopal, A., Bae, Y., Lee, B.H.,
Mumm, S., Gu, C., Baker, J.C., Mohseni, M., Sum, M., Huskey, M., Duan, S., Bijanki, V.N., Civitelli, R., Gardner,
M.J., McAndrew, C.M., Ricci, W.M., Gurnett, C.A., Diemer, K., Wan, F., Costantino, C.L., Shannon, K.M., Raje, N.,
Dodson, T.B., Haber, D.A., Carette, J.E., Varadarajan, M., Brummelkamp, T.R., Birsoy, K., Sabatini, D.M., Haller, G.,
Peterson, T.R., (2020) ATRAID regulates the action of nitrogen-containing bisphosphonates on bone. Science
Translational Medicine, 12:544, eaav9166
Yu, Z., Surface, L.E., Park, C.Y., Horlbeck, M.A., Wyant, G.A., Abu-Remaileh, M., Peterson, T.R., Sabatini, D.M.,
Weissman, J.S., O’Shea, E.K., (2018) Identification of a transporter complex responsible for the cytosolic entry of
nitrogen-containing bisphosphonates. Elife 7:e36620
Surface, L.E.*, Fields, P.F*, Subramanian, V., Behmer, R., Udeshi, N., Peach, S.E., Carr, S.A., Jaffe, J.D., Boyer, L.A.
(2016) H2A.Z.1 monoubiquitylation antagonizes BRD2 to maintain poised chromatin in ESCs. Cell Reports, 14, 1142-
1155. *equal contribution
Subramanian, V., Mazumder, A., Surface, L.E., Butty, V.L., Fields, P.A., Alwan, A., Torrey, L., Thai, K.K., Levine,
S.S., Bathe, M., Boyer, L.A. (2013) H2A.Z acidic patch couples chromatin dynamics to regulation of gene expression
programs during ESC differentiation. PLoS Genetics, 9, e1003725
Klattenhoff, C*., Sheuermann, J.C.*, Surface, L.E., Bradley, R.K., Fields, P., Steinhauser, M.L., Ding, H., Butty, V.L.,

Torrey, L., Haas S., Abo, R., Tabebordbar, M., Lee, R.T., Burge, C.B., Boyer, L.A. (2013) Braveheart, a long non-
coding RNA required for cardiovascular lineage commitment. Cell 152, 1-14. *equal contribution

Surface, L.E.*, Thornton, S.R.*, Boyer, L.A. (2010) Polycomb group proteins set the stage for early lineage
commitment. Cell Stem Cell 7, 288-298. *equal contribution
Lockshon, D., Surface L.E., Kerr, E.O., Kaeberlein, M., Kennedy, B.K. (2007). The sensitivity of yeast mutants to
oleic acid implicates the peroxisome and other processes in membrane function. Genetics 175, 77-91.
SERVICE & OUTREACH EXPERIENCE
Member, American Society of Bone and Mineral Research, Early Stage Investigator Committee, 2022-Present
Member, Oral Health Sciences PhD Program Committee University of Michigan, 2022-Present
Abstract Reviewer, American Society of Bone and Mineral Research, Annual Meeting, 2020-Present
Workshop Committee Member, Center for Skeletal Research, 2019-2021
-Plan instructional workshops for the Boston-area skeletal research community.
Grant Reviewer, Seeding Labs (Non-profit science development organization), Boston, MA, 2016-Present
-Review grant applications for instrument access grants provided to laboratories in developing countries
-Contributed to data analysis of existing grants
Mentor, Science Club for Girls, Roxbury, MA, 2015-2019
-Led middle school girls from diverse backgrounds in weekly science clubs on Saturdays to engage them with
science and technology
Postdoc Liason Committee, Harvard Department of Molecular and Cellular Biology, 2015-2017
-Served on a committee that advocates for issues relevant for postdocs and beyond. Advocated for the
department to consider a preprint server policy, and bringing in a more diverse set of scientists for talks.
Science Fair Judge, Quincy High School, Quincy, MA, 2010-2021
-Judged the science fair of a diverse high school near Boston, and spoke with attendees about my own career
path through science.

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Lecture / Discussion Thu, 15 Sep 2022 11:20:30 -0400 2022-10-06T12:00:00-04:00 2022-10-06T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Lecture / Discussion Lauren Surface, PhD
OHS Seminar Series Schedule (October 6, 2022 12:00pm) https://events.umich.edu/event/98131 98131-21795617@events.umich.edu Event Begins: Thursday, October 6, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

OHS Seminar Series Schedule Fall 2022 - Stay tuned for more updates!

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Presentation Tue, 06 Sep 2022 13:16:28 -0400 2022-10-06T12:00:00-04:00 2022-10-06T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Presentation OHS Seminar Series Schedule Fall 2022
Towards a digital lung for medical research and applications (October 6, 2022 4:30pm) https://events.umich.edu/event/99561 99561-21798343@events.umich.edu Event Begins: Thursday, October 6, 2022 4:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Abstract:
Respiratory infections and chronic diseases have been among the top causes of death worldwide for decades, killing over 8 million people annually. Current diagnostic methods for respiratory diseases result in late diagnosis and high rates of underdiagnosis. Further, the wide variability in the patient response to treatment challenges population-based therapies. Personalized medicine arises as a promising alternative to standard practice, but it relies on expensive laboratory and testing infrastructure not available worldwide. This motivates the creation of computational models of the human lungs for in silico research and applications.

In this talk, I will present our group's efforts to construct computational models of the lung for medical research and applications. I will review how computer simulations of alveolar structures informed by micro-computed tomography can change our current understanding of the forces acting on the lung extracellular matrix (ECM). Further, I will discuss a class of microstructurally informed models for predicting the lung tissue response and how they can capture mechanical changes in lung mechanics triggered by ECM remodeling. Finally, I will show our current work on creating personalized virtual lungs and how we can use them to simulate the response of patients under respiratory failure that are connected to mechanical ventilation.

Bio:
Daniel E. Hurtado is an associate professor with the School of Engineering at PUC Chile, and a visiting professor at the Institute for Medical Engineering and Science at MIT. He leads the Computational Medicine Group, an interdisciplinary team that focuses on the creation of personalized computational replicas of the human lungs, with applications in the study of mechanical ventilation and early diagnosis of pulmonary diseases. His work also involves the development of wearable respiratory systems to monitor breathing in athletes and hospital patients. 

Prof. Hurtado received his M.S. and Ph.D. degrees from the California Institute of Technology as a Fulbright fellow. His thesis work made him the recipient of the Robert J. Melosh Medal, presented by Duke University. In 2018, the World Economic Forum selected him as one of the 50 most influential young scientists worldwide under 40 years old for his contributions in research and innovation in biomedical engineering. He is also an elected member for the World Council of Biomechanics.

Zoom:
https://umich.zoom.us/j/91375430500

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Workshop / Seminar Thu, 29 Sep 2022 15:17:19 -0400 2022-10-06T16:30:00-04:00 2022-10-06T17:30:00-04:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar BME 500 Seminar
CGIS Study Abroad Fair (October 11, 2022 12:00pm) https://events.umich.edu/event/96881 96881-21793528@events.umich.edu Event Begins: Tuesday, October 11, 2022 12:00pm
Location: Michigan Union
Organized By: Center for Global and Intercultural Study

Learn about 115+ programs in over 45 countries, ask about U-M faculty-led programs, and figure out which program can help satisfy your major/minor requirements. CGIS has programs ranging from a few weeks to an academic year! Meet with CGIS advisors, staff from the Office of Financial Aid and the LSA Scholarship Office, CGIS Alumni, and other on-campus offices who can help you select a program that works best for you.

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Fair / Festival Tue, 04 Oct 2022 11:40:54 -0400 2022-10-11T12:00:00-04:00 2022-10-11T16:00:00-04:00 Michigan Union Center for Global and Intercultural Study Fair / Festival Join us for the CGIS Study Abroad Fair on October 11, 2022
EMERSE Meeting Series (October 11, 2022 1:00pm) https://events.umich.edu/event/98192 98192-21795695@events.umich.edu Event Begins: Tuesday, October 11, 2022 1:00pm
Location: Off Campus Location
Organized By: Department of Learning Health Sciences

Speaker:
Mark Beno, MSM
Executive Director, Cleveland Institute for Computational Biology,
School of Medicine, Case Western Reserve University

The Electronic Medical Record Search Engine (EMERSE) was installed at University Hospitals of Cleveland (UH) in 2021 by the Cleveland Institute for Computational Biology (CICB), a collaboration between Case Western Reserve University (CWRU) and UH.  At present, EMERSE contains indexed medical notes from 2018 through present for over 1.7 million UH patients.  This presentation will discuss the strategies we employed to successfully install EMERSE, the lessons-learned in rolling out EMERSE to research and operational teams, some research success stories since EMERSE adoption, and the additional tools we have developed as add-ons to the EMERSE application that we use internally for tracking EMERSE metrics and plan to share with the broader EMERSE community.

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Lecture / Discussion Tue, 06 Sep 2022 23:35:08 -0400 2022-10-11T13:00:00-04:00 2022-10-11T14:00:00-04:00 Off Campus Location Department of Learning Health Sciences Lecture / Discussion EMERSE logo
Information Session Webinar- Michigan Program in Survey and Data Science (MPSDS) (October 12, 2022 3:00pm) https://events.umich.edu/event/98336 98336-21796508@events.umich.edu Event Begins: Wednesday, October 12, 2022 3:00pm
Location: Off Campus Location
Organized By: Michigan Program in Survey and Data Science

Wednesday, October 12, 2002
3:00 - 4:00pm
Registration is required.

Please join us October 12, 2022 to learn about the Michigan Program in Survey and Data Science. The speaker will be Dr. Brady West.

Advance registration is required, https://bit.ly/3d3upwR

The Michigan Program in Survey and Data Science (MPSDS) offers graduate degrees that combine ideas and techniques for producing and analyzing data about humans and our society. Joint us to launch your career in this exciting and rewarding field in which scientists interpret the world through data.

The University of Michigan Program in Survey Methodology was established in 2001 seeking to train future generations of survey and data scientists. In 2021, we changed our name to the Michigan Program in Survey and Data Science. Our curriculum is concerned with a broad set of data sources including survey data, but also including social media posts, sensor data, and administrative records, as well as analytic methods for working with these new data sources. And we bring to data science a focus on data quality — which is not at the center of traditional data science. The new name speaks to what we teach and work on at the intersection of social research and data. The program offers doctorate and master of science degrees and a certificate through the University of Michigan. The program's home is the Institute for Social Research, the world's largest academically-based social science research institute.

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Presentation Thu, 08 Sep 2022 14:38:06 -0400 2022-10-12T15:00:00-04:00 2022-10-12T16:00:00-04:00 Off Campus Location Michigan Program in Survey and Data Science Presentation MPSDS Informational Session Webinar
DCMB / CCMB Weekly Seminar (October 12, 2022 4:00pm) https://events.umich.edu/event/99377 99377-21797973@events.umich.edu Event Begins: Wednesday, October 12, 2022 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract:

Our current understanding of how genes are regulated is akin to solving a jigsaw puzzle. Many factors governing gene expression have been identified, and researchers have collected a wide variety of related datasets. However, how these "parts" are pieced together to function as a whole remains unclear. In this talk, I will discuss our research to develop and apply state-of-the-art machine learning methods to genomics datasets to attempt to put together the pieces from the data. I will cover our work using deep learning architecture that captures the data's underlying structure to integrate datasets and connect them to gene expression via the prediction task. We also interpret the prediction results and tie them back to contributing factors to develop potential hypotheses related to gene regulation. I will then move from bulk data to the single-cell data domain and discuss methods to perform unsupervised integration of different types of single-cell experiments. This talk aims to highlight our research direction's potential to reveal the important gene regulatory mechanisms in characterizing cell types and diseases from the collected data.

Bio:

Ritambhara Singh is an Assistant Professor in the Computer Science department and a faculty member of the Center for Computational Molecular Biology at Brown University. Her research lab works at the intersection of machine learning and biology. Prior to joining Brown, Singh was a post-doctoral researcher in the Noble Lab at the University of Washington. She completed her Ph.D. in 2018 from the University of Virginia with Dr. Yanjun Qi as her advisor. Her research has involved developing machine learning algorithms for the analysis of biological data as well as applying deep learning models to novel biological and biomedical applications. She recently received the NHGRI Genomic Innovator Award for developing deep learning methods to integrate and model genomics datasets. URL: https://vivo.brown.edu/display/rsingh47

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Lecture / Discussion Tue, 27 Sep 2022 09:32:07 -0400 2022-10-12T16:00:00-04:00 2022-10-12T17:00:00-04:00 Palmer Commons DCMB Seminar Series Lecture / Discussion Ritambhara Singh, Asst. Professor (Brown University)
Mind Matters: Addiction 101 - Addiction & the Brain (October 12, 2022 7:00pm) https://events.umich.edu/event/99587 99587-21798368@events.umich.edu Event Begins: Wednesday, October 12, 2022 7:00pm
Location: Off Campus Location
Organized By: UM Addiction Center

The U-M Addiction Center is hosting a free, virtual community education series designed for individuals and families. Join experts from U-M Addiction Treatment Services (UMATS), live via Zoom to learn more about important topics related to addiction and recovery.

This first session in the 4-part series will take place on October 12th from 7-8pm via Zoom. Participants will learn helpful information about addiction and how it changes the brain and behavior. Registration required.

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Livestream / Virtual Fri, 30 Sep 2022 09:31:44 -0400 2022-10-12T19:00:00-04:00 2022-10-12T20:00:00-04:00 Off Campus Location UM Addiction Center Livestream / Virtual Click on the link below to register
DCM&B Tools and Technology Seminar (October 13, 2022 12:00pm) https://events.umich.edu/event/96851 96851-21793402@events.umich.edu Event Begins: Thursday, October 13, 2022 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

The current COVID-19 pandemic and the previous SARS/MERS outbreaks of 2003 and 2012 have resulted in a series of major global public health crises. We must integrate the large and exponentially growing amount of heterogeneous coronavirus data to better understand coronaviruses and associated disease mechanisms, in the interest of developing effective and safe vaccines and drugs. Ontologies play an important role in standard-based knowledge and data representation, integration, sharing, and analysis. Accordingly, we initiated the development of the community-based Coronavirus Infectious Disease Ontology (CIDO) in early 2020.

Tool Link: https://github.com/CIDO-ontology/cido

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

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Presentation Mon, 15 Aug 2022 10:49:10 -0400 2022-10-13T12:00:00-04:00 2022-10-13T13:00:00-04:00 Palmer Commons DCMB Tools and Technology Seminar Presentation
Glucose metabolism in bone biology and diabetic osteopenia (October 13, 2022 12:00pm) https://events.umich.edu/event/98788 98788-21797183@events.umich.edu Event Begins: Thursday, October 13, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

I have been studying skeletal development and homeostasis for over 25 years. I am interested in understanding the molecular and metabolic regulation of skeletal cell types both in the embryo and in adults under normal or pathological conditions. The work has led to new insights into the metabolic features of chondrocytes, osteoblasts and osteoclasts. Studies of Hh, Wnt, Bmp and Notch signaling have uncovered metabolic reprogramming as a common link for developmental signals to regulate the fate and activity of skeletal cells. In a separate line of work, we have sought to elucidate the molecular identify and regulation of mesenchymal stem and progenitor cells in bone. This pursuit has led to the discovery of Gli1+ mesenchymal progenitors as the main source for osteoblasts in growing bones (Shi et al., 2017, Nat Commun., PMC
5725597). More recently, we have demonstrated a critical role for the Gli1+ progenitors in mediating the bone
anabolic role of teriparatide, the main bone anabolic therapy for osteoporosis (Shi et al, 2021, Cell Rep, in
press). The current proposal extends our work on mesenchymal progenitors and builds on the discovery of a
potential adipo-osteoprogenitor in the adult bone marrow. Completion of the proposed study is expected to
uncover the role of the newly discovered progenitors in bone homeostasis, skeletal aging and diabetic
osteopenia.

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Lecture / Discussion Thu, 15 Sep 2022 09:48:26 -0400 2022-10-13T12:00:00-04:00 2022-10-13T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Lecture / Discussion Fanxin Long, PhD William W. Smith Endowed Chair in Pediatric Genomic Research The Children's Hospital of Philadelphia Professor of Orthopedic Surgery University of Pennsylvania
OHS Seminar Series Schedule (October 13, 2022 12:00pm) https://events.umich.edu/event/98131 98131-21795618@events.umich.edu Event Begins: Thursday, October 13, 2022 12:00pm
Location: Dental & W.K. Kellogg Institute
Organized By: Office of Research School of Dentistry

OHS Seminar Series Schedule Fall 2022 - Stay tuned for more updates!

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Presentation Tue, 06 Sep 2022 13:16:28 -0400 2022-10-13T12:00:00-04:00 2022-10-13T13:00:00-04:00 Dental & W.K. Kellogg Institute Office of Research School of Dentistry Presentation OHS Seminar Series Schedule Fall 2022