Happening @ Michigan https://events.umich.edu/list/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. Department of Computational Medicine & Bioinformatics Weekly Seminar (December 1, 2021 4:00pm) https://events.umich.edu/event/88514 88514-21654664@events.umich.edu Event Begins: Wednesday, December 1, 2021 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract:

Epigenetic control of gene expression is highly cell-type- and context-specific. Yet, despite its complexity, gene regulatory logic can be broken down into modular components consisting of a transcription factor (TF) activating or repressing the expression of a target gene through its binding to a cis-regulatory region. Recent advances in joint profiling of transcription and chromatin accessibility with single-cell resolution offer unprecedented opportunities to interrogate such regulatory logic. Here, we propose a nonparametric approach, TRIPOD, to detect and characterize three-way relationships between a TF, its target gene, and the accessibility of the TF’s binding site, using single-cell RNA and ATAC multiomic data. We apply TRIPOD to interrogate cell-type-specific regulatory logic in peripheral blood mononuclear cells and contrast our results to detections from enhancer databases, cis-eQTL studies, ChIP-seq experiments, and TF knockdown/knockout studies. We then apply TRIPOD to mouse embryonic brain data during neurogenesis and gliogenesis and identified known and novel putative regulatory relationships, validated by ChIP-seq and PLAC-seq. Finally, we demonstrate TRIPOD on SHARE-seq data of differentiating mouse hair follicle cells and identify lineage-specific regulation supported by histone marks for gene activation and super-enhancer annotations.

Hosted by: Joshua Welch, PhD

Speaker will be in-person and the seminar will be live-streamed via Zoom.

Zoom: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Lecture / Discussion Thu, 21 Oct 2021 14:55:35 -0400 2021-12-01T16:00:00-05:00 2021-12-01T17:00:00-05:00 Palmer Commons DCMB Seminar Series Lecture / Discussion Yuchao Jiang (Assistant Professor in the Departments of Biostatistics and Genetics at UNC)
U-M Structure Seminar: "Structural studies of JuvEV modular polyketide synthase" (December 3, 2021 10:00am) https://events.umich.edu/event/86440 86440-21634315@events.umich.edu Event Begins: Friday, December 3, 2021 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

Sean Newmister, Ph.D.
Research Investigator
University of Michigan, Sherman Lab

Hybrid: LSI Library and Zoom - https://umich.zoom.us/j/97763780708 (Password: structure)

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Workshop / Seminar Fri, 19 Nov 2021 11:43:36 -0500 2021-12-03T10:00:00-05:00 2021-12-03T11:00:00-05:00 Life Sciences Institute U-M Structural Biology Workshop / Seminar U-M Structure
U-M Structure Seminar: "The Structural and Functional Diversity of Microbial Encapsulin Nanocompartments" (December 17, 2021 10:00am) https://events.umich.edu/event/86442 86442-21634317@events.umich.edu Event Begins: Friday, December 17, 2021 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

Michael Andreas, Ph.D.
Postdoctoral Research Fellow
University of Michigan, Giessen Lab

Hybrid: LSI Library and Zoom - https://umich.zoom.us/j/97763780708 (Password: structure)

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Workshop / Seminar Wed, 01 Dec 2021 11:14:17 -0500 2021-12-17T10:00:00-05:00 2021-12-17T11:00:00-05:00 Life Sciences Institute U-M Structural Biology Workshop / Seminar U-M Structure
Cryo-ET Pipeline for Imaging Small Proteins in Large Biological Structures (January 13, 2022 9:30am) https://events.umich.edu/event/90501 90501-21671200@events.umich.edu Event Begins: Thursday, January 13, 2022 9:30am
Location: Taubman Biomedical Science Research Building
Organized By: U-M Structural Biology

Correlative Light, and Electron Microscopy (CLEM) Faculty Candidate Seminar

Shiwei Zhu, Ph.D.
Research Specialist- MacMicking Lab, HHMI-Immunology & Microbial Pathogenesis, Yale Systems Biology Institute, Yale University

Hosted by: Cell and Developmental Biology & The Life Sciences Institute

Hybrid Zoom Meeting link: https://umich.zoom.us/j/99429897480 for those that are unable to attend

The venue is accessible via elevator and ramp and if you require any accommodations to fully participate in this activity, please inform:
Lori Mirabitur - Phone: (734) 615-7509 - Email: longeway@umich.edu

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Lecture / Discussion Thu, 06 Jan 2022 12:23:25 -0500 2022-01-13T09:30:00-05:00 2022-01-13T10:30:00-05:00 Taubman Biomedical Science Research Building U-M Structural Biology Lecture / Discussion flier
Grad School Interviews Office Hour (January 21, 2022 10:00am) https://events.umich.edu/event/91167 91167-21677027@events.umich.edu Event Begins: Friday, January 21, 2022 10:00am
Location: Off Campus Location
Organized By: Futures in Research, Science, Teaching - FIRST

If you would like to ask current biology grad students about what interviewing at different grad programs is like, or practice interviewing yourself, please stop by.

Zoom link: https://umich.zoom.us/j/99108550897

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Workshop / Seminar Tue, 18 Jan 2022 11:11:32 -0500 2022-01-21T10:00:00-05:00 2022-01-21T11:00:00-05:00 Off Campus Location Futures in Research, Science, Teaching - FIRST Workshop / Seminar FIRST Logo with the name made out of chromosomes separating during mitosis.
U-M Structure Seminar: "Structural and dynamics investigation of NPSL2 by NMR" (January 21, 2022 10:00am) https://events.umich.edu/event/85434 85434-21626421@events.umich.edu Event Begins: Friday, January 21, 2022 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

Yaping Liu, Ph.D.
Postdoctoral Research Fellow
University of Michigan, Sarah Keane Lab

Hybrid: LSI Library and Zoom - https://umich.zoom.us/j/97763780708 (Password: structure)

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Workshop / Seminar Mon, 03 Jan 2022 13:13:44 -0500 2022-01-21T10:00:00-05:00 2022-01-21T11:00:00-05:00 Life Sciences Institute U-M Structural Biology Workshop / Seminar U-M Structure
Bridging structural biology and virology: imaging processes in the native cellular context at molecular resolution (January 24, 2022 11:30am) https://events.umich.edu/event/90559 90559-21671685@events.umich.edu Event Begins: Monday, January 24, 2022 11:30am
Location: Taubman Biomedical Science Research Building
Organized By: U-M Structural Biology

Correlative Light and Electron Microscopy (CLEM) Faculty Candidate Seminar

Luiza Mendonca, Ph.D.
Research Fellow, Wellcome Centre for Human
Genetics, Division of Structural Biology
(STRUBI), University of Oxford

Hosted By:
Department of Cell and Developmental Biology
Life Science Institute
Biosciences Initiative

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Lecture / Discussion Thu, 06 Jan 2022 12:20:14 -0500 2022-01-24T11:30:00-05:00 2022-01-24T12:30:00-05:00 Taubman Biomedical Science Research Building U-M Structural Biology Lecture / Discussion Luiza
RNA Faculty Candidate Seminar (January 31, 2022 4:00pm) https://events.umich.edu/event/89608 89608-21664520@events.umich.edu Event Begins: Monday, January 31, 2022 4:00pm
Location: Taubman Biomedical Science Research Building
Organized By: Center for RNA Biomedicine

In-person/Hybrid seminar co-hosted by the Center for RNA Biomedicine, the Department of Biological Chemistry and the Department of Biophysics

Talk title: “The scanning mechanism of mRNA translation initiation in humans”

Keywords: mRNA, translation, ribosome, helicase

Abstract: Decoding the genetic information into protein is fundamental for all kingdoms of life. It requires precise mechanisms to transcribe the DNA into mRNA, which then can be translated by the ribosome to produce proteins. Translation initiation of eukaryotic mRNAs is a dynamic process regulated by over a dozen protein eukaryotic initiation factors (eIFs). This process starts with the binding of eukaryotic initiation factors eIF1, eIF1A, eIF3, eIF5, and a ternary complex of eIF2–GTP–tRNAiMet (TC) to the 40S small ribosomal subunit, forming the 43S preinitiation complex (43S PIC). Once assembled, the 43S PIC is recruited to the 5′ untranslated region (UTR) of mRNA by the multifactor cap-binding complex eIF4F, forming the 48S initiation complex (48S). The 48S then scans along the 5′ UTR mRNA to locate a start codon. The eIF4F binding site in the 48S and how mRNA is inserted into the mRNA channel in the 40S small ribosomal subunit remained unknown. To gain insights into the molecular mechanism underlining the assembly of the 48S, we used cryo-electron microscopy to determine the structure of a reconstituted human 48S. The structure sheds light on the early events of translation initiation complex assembly, including how eIF4F interacts with the 43S during the scanning process.

If you are having trouble registering, please contact Martina Jerant at mjerant@umich.edu

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Lecture / Discussion Tue, 04 Jan 2022 11:24:42 -0500 2022-01-31T16:00:00-05:00 2022-01-31T17:00:00-05:00 Taubman Biomedical Science Research Building Center for RNA Biomedicine Lecture / Discussion Jailson (Jay) Brito Querido, MRC Laboratory of Molecular Biology
U-M Structure Seminar: “The GRAFFENDOR (Graphene-based Affinity grid for the Endogenous Proteins) Grid" (February 18, 2022 10:00am) https://events.umich.edu/event/85437 85437-21626424@events.umich.edu Event Begins: Friday, February 18, 2022 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

Uhn-Soo Cho, Ph.D.
Associate Professor of Biological Chemistry, Medical School
University of Michigan

Hybrid: LSI Library and Zoom - https://umich.zoom.us/j/97763780708 (Password: structure)

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Workshop / Seminar Mon, 24 Jan 2022 08:22:17 -0500 2022-02-18T10:00:00-05:00 2022-02-18T11:00:00-05:00 Life Sciences Institute U-M Structural Biology Workshop / Seminar U-M Structure
Weekly Seminar for DCMB / CCMB (February 23, 2022 4:00pm) https://events.umich.edu/event/92060 92060-21686457@events.umich.edu Event Begins: Wednesday, February 23, 2022 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

In the Peixoto lab we use genomic approaches to understand gene expression and its epigenetic regulation in response to learning and sleep deprivation, and its alteration in autism spectrum disorders. This requires combining behavioral paradigms in mice, molecular biology and the analysis of high-throughput data in the brain in vivo. It also requires using the right data analysis tools to be able to capture the effect of learning or sleep in the context of an ever-active brain. In this talk we will discuss the effects of learning on chromatin accessibility and the effects of sleep loss in gene expression, with an emphasis on how data analysis influences our ability to detect novel and reproducible biology.

Short bio:

Lucia Peixoto received her bachelor’s degree in Biochemistry from the Universidad de la Republica in her native Uruguay in 2002. She subsequently earned her Ph.D. at The University of Pennsylvania under the mentorship of Dr. David S. Roos, using genomic and computational biology approaches to understand host-pathogen interactions. She completed her postdoctoral training in Neuroscience with Dr. Ted Abel at The University of Pennsylvania in 2015. During her fellowship, she was also a trainee at the Training Program in Neurodevelopmental disabilities at the Children’s Hospital of Philadelphia. As a trainee at CHOP, she completed a clinical internship at the Center for Autism Research under the supervision of Dr. Robert Schultz. She became an Assistant Professor at Washington State University in 2015 and has since been recognized with a K01 Early Career Faculty award from NIH/NINDS and a pilot award from the Simons Foundation Autism Research Initiative. She is also a member of the board of directors of the International Society of computational biology (ISCB) and cochair the Equity, Diversity and Inclusion committee of ISCB. Her lab uses behavior, electrophysiology, molecular biology and genomic approaches to understand how sleep and learning modulate transcription and how this may be altered in Autism Spectrum Disorders.

Zoom livestream link: https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Workshop / Seminar Mon, 07 Feb 2022 14:54:44 -0500 2022-02-23T16:00:00-05:00 2022-02-23T17:00:00-05:00 Off Campus Location DCMB Seminar Series Workshop / Seminar
U-M Structure Seminar: "Machine learning in cryo-EM" (February 25, 2022 10:00am) https://events.umich.edu/event/85438 85438-21626425@events.umich.edu Event Begins: Friday, February 25, 2022 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

Yilai Li, Ph.D.
Postdoctoral Research Fellow
University of Michigan, Cianfrocco Lab

This seminar is only open to UM researchers.

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Workshop / Seminar Wed, 02 Feb 2022 10:48:48 -0500 2022-02-25T10:00:00-05:00 2022-02-25T11:00:00-05:00 Life Sciences Institute U-M Structural Biology Workshop / Seminar U-M Structure
U-M Structure Seminar: "Defining Human Cytochrome P450 8B1 Structure and Function: Supporting Drug Design for Nonalcoholic Fatty Liver Disease and Diabetes" (March 4, 2022 10:00am) https://events.umich.edu/event/85439 85439-21626426@events.umich.edu Event Begins: Friday, March 4, 2022 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

Jinghan Liu
Graduate Student
University of Michigan, Emily Scott Lab

Hybrid: LSI Library and Zoom - https://umich.zoom.us/j/97763780708 (Password: structure)

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Workshop / Seminar Thu, 10 Feb 2022 12:49:21 -0500 2022-03-04T10:00:00-05:00 2022-03-04T11:00:00-05:00 Life Sciences Institute U-M Structural Biology Workshop / Seminar U-M Structure
Data Science in Health Disparities Research Symposium (March 11, 2022 9:00am) https://events.umich.edu/event/91976 91976-21684826@events.umich.edu Event Begins: Friday, March 11, 2022 9:00am
Location: Palmer Commons
Organized By: DCMB Seminar Series

Additional speakers on the topics of:

How data science can be used to understand racial health disparities

How data science with biased data exacerbates health disparities

Lunch and discussion sessions following the talks.

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Workshop / Seminar Mon, 07 Feb 2022 10:37:38 -0500 2022-03-11T09:00:00-05:00 2022-03-11T15:00:00-05:00 Palmer Commons DCMB Seminar Series Workshop / Seminar
U-M Structure Seminar: "High throughput screening of small molecule binding partners for the FMN riboswitch by a multidisciplinary approach" (March 18, 2022 10:00am) https://events.umich.edu/event/85436 85436-21626423@events.umich.edu Event Begins: Friday, March 18, 2022 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

Elizabeth Tidwell
Graduate Student
University of Michigan, Koutmos Lab

Hybrid: LSI Library and Zoom - https://umich.zoom.us/j/97763780708 (Password: structure)

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Workshop / Seminar Thu, 03 Mar 2022 11:40:42 -0500 2022-03-18T10:00:00-04:00 2022-03-18T11:00:00-04:00 Life Sciences Institute U-M Structural Biology Workshop / Seminar U-M Structure
UM Structure Seminar: "Structures in situ: Discovering a new lattice inside alpha-carboxysomes" (March 25, 2022 12:00pm) https://events.umich.edu/event/89500 89500-21663332@events.umich.edu Event Begins: Friday, March 25, 2022 12:00pm
Location: Life Sciences Institute
Organized By: U-M Structural Biology

Lauren Ann Metskas, Ph.D.
Assistant Professor
Purdue University

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Lecture / Discussion Mon, 28 Feb 2022 08:56:39 -0500 2022-03-25T12:00:00-04:00 2022-03-25T13:00:00-04:00 Life Sciences Institute U-M Structural Biology Lecture / Discussion U-M Structure
DCMB / CCMB Weekly Seminar presents Rehan Akbani, PhD (Associate Professor, University of Texas, MD Anderson Cancer Center) (March 30, 2022 4:00pm) https://events.umich.edu/event/93933 93933-21711327@events.umich.edu Event Begins: Wednesday, March 30, 2022 4:00pm
Location: Off Campus Location
Organized By: DCMB Seminar Series

Abstract:

The TP53 tumor suppressor gene is frequently mutated in human cancers. We illustrate the “omics” landscape of the TP53 pathway across five data platforms in 10,225 patient samples from 33 cancers reported by The Cancer Genome Atlas (TCGA). More than 91% of TP53-mutant cancers exhibit second allele loss by mutation, chromosomal deletion, or copy-neutral loss of heterozygosity. TP53 mutations are associated with enhanced chromosomal instability, including increased amplification of oncogenes and deep deletion of tumor suppressor genes. Tumors with TP53 mutations differ from their non-mutated counterparts in RNA, miRNA, and protein expression patterns, with mutant TP53 tumors displaying enhanced expression of cell cycle progression genes and proteins. A mutant TP53 RNA expression signature shows significant correlation with reduced survival in 11 cancer types. Pathway activity scores were computed for all the samples using mRNA expression levels of ten TP53 pathway member genes. Gynecologic cancers show high activity of the pathway. The pathway is correlated with immune infiltration and EMT, and anti-correlated with RTK and RAS/MAPK pathways. In particular, a strong correlation with immune infiltration is observed in breast cancer. ATAC-seq data also show high chromatin accessibility of the pathway genes in breast cancer. Thus, the TP53 pathway has profound effects on tumor cell genomic structure, expression, and clinical outlook depending on tumor type.

Short Bio
Dr. Rehan Akbani is an Associate Professor at the University of Texas MD Anderson Cancer Center in Houston, Texas, in the Department of Bioinformatics and Computational Biology. He has worked at MD Anderson since 2009. He has played many leadership roles in major enterprises, including as PI on TCGA’s MD Anderson Genome Data Analysis Center (GDAC) grant. Within the TCGA consortium, he led four of TCGA’s analysis working groups and he’s been a co-author on each one of TCGA’s 33 marker papers and 27 pan-cancer papers since 2009. His primary contributions have been leading the analysis of proteomics data, and batch effects and quality control of omics data. He won the AACR “Team Science Award” in 2020 for his work in TCGA. He was conferred the “Highly Cited Researchers 2019” award by Web of Science for co-authoring the most highly cited papers in the past decade. He has over 87,700 citations and an h-index of 78 on Google Scholar. In 2014, he won the “Test of Time” award from the European Conference on Machine Learning (ECML) for publishing the most highly cited paper in ECML a decade ago. Currently, Dr. Akbani is the Co-Director of MD Anderson’s proteomics core and Co-Director of the metabolomics core, where he’s led the development of software pipelines for normalizing raw data and generating customer reports semi-automatically. He’s also contributed proteomics data analysis for projects including the Cancer Cell Line Encyclopedia (CCLE) and the MD Anderson Cell Line Project (MCLP).

Host: Veera Baladandayuthapani, Ph.D.
https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Lecture / Discussion Thu, 24 Mar 2022 12:32:18 -0400 2022-03-30T16:00:00-04:00 2022-03-30T17:00:00-04:00 Off Campus Location DCMB Seminar Series Lecture / Discussion Rehan Akbani, PhD (Associate Professor, University of TX MD Anderson Cancer Center)
U-M Structure Seminar: "Size doesn't matter: de novo generation of llama-derived nanobodies for biological research" (April 15, 2022 10:00am) https://events.umich.edu/event/90345 90345-21670437@events.umich.edu Event Begins: Friday, April 15, 2022 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

Matthias Truttman, Ph.D.
Assistant Professor, Department of Molecular & Integrative Physiology
University of Michigan

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Livestream / Virtual Wed, 23 Mar 2022 10:41:54 -0400 2022-04-15T10:00:00-04:00 2022-04-15T11:00:00-04:00 Life Sciences Institute U-M Structural Biology Livestream / Virtual structure
U-M Structure Seminar: "Structural and kinetic characterization of a minimal archaeal RNase P" (April 29, 2022 10:00am) https://events.umich.edu/event/85441 85441-21626428@events.umich.edu Event Begins: Friday, April 29, 2022 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

Catherine Wilhelm
Graduate Student
University of Michigan, Koutmos Lab

Hybrid: LSI Library and Zoom - https://umich.zoom.us/j/97763780708 (Password: structure)

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Workshop / Seminar Mon, 11 Apr 2022 14:00:58 -0400 2022-04-29T10:00:00-04:00 2022-04-29T11:00:00-04:00 Life Sciences Institute U-M Structural Biology Workshop / Seminar U-M Structure
Science Communication Certificate Program (September 12, 2022 12:00pm) https://events.umich.edu/event/98347 98347-21796523@events.umich.edu Event Begins: Monday, September 12, 2022 12:00pm
Location:
Organized By: Futures in Research, Science, Teaching - FIRST

A science communication program run by the Museum of Natural History and the MCDB department. Create a video based on a past research project/experience to be shared on the Museum's website. Completion of the workshops and final video will earn a science communication certificate.

More details:
https://drive.google.com/file/d/1R0o_bkRGMgPn7L_MVSD_V4b3_j3p8a-Y/view?usp=sharing

Application deadline is Sept. 12th

Please email us with any questions:
SECOND.Contact@umich.edu

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Workshop / Seminar Thu, 08 Sep 2022 17:46:46 -0400 2022-09-12T12:00:00-04:00 2022-09-12T12:00:00-04:00 Futures in Research, Science, Teaching - FIRST Workshop / Seminar SECOND Science Communication
Cargo Transport by Dynein/Dynactin (September 13, 2022 12:00pm) https://events.umich.edu/event/98199 98199-21795702@events.umich.edu Event Begins: Tuesday, September 13, 2022 12:00pm
Location:
Organized By: U-M Structural Biology

University of Michigan Department of Biological Chemistry is hosting Dr. Andrew Carter, MRC-LMB to provide a talk titled "Cargo Transport by Dynein/Dynactin"

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Livestream / Virtual Wed, 07 Sep 2022 08:13:03 -0400 2022-09-13T12:00:00-04:00 2022-09-13T13:00:00-04:00 U-M Structural Biology Livestream / Virtual
Structure and Function of a Bacterial Histone Lysine Methyltransferase in Pathogenesis: How Bacteria Read and Write Histone Modifications (September 23, 2022 10:00am) https://events.umich.edu/event/98380 98380-21796578@events.umich.edu Event Begins: Friday, September 23, 2022 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

University of Michigan, Department of Biological Chemistry

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Workshop / Seminar Fri, 16 Sep 2022 11:51:02 -0400 2022-09-23T10:00:00-04:00 2022-09-23T11:00:00-04:00 Life Sciences Institute U-M Structural Biology Workshop / Seminar RT Seminar Flier
Structural Basis for HCMV Receptor Recognition and Antibody Neutralization (September 27, 2022 12:00pm) https://events.umich.edu/event/98200 98200-21795703@events.umich.edu Event Begins: Tuesday, September 27, 2022 12:00pm
Location: Medical Science Unit I
Organized By: U-M Structural Biology

Genentech

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Workshop / Seminar Wed, 07 Sep 2022 09:00:13 -0400 2022-09-27T12:00:00-04:00 2022-09-27T13:00:00-04:00 Medical Science Unit I U-M Structural Biology Workshop / Seminar
Conformational Change of Methylenetetrahydrofolate Reductase in the Allosteric Regulation: Crystal Structure of Eukaryotic MTHFR in Complex with S-Adenosylmethionine (September 30, 2022 10:00am) https://events.umich.edu/event/98738 98738-21797129@events.umich.edu Event Begins: Friday, September 30, 2022 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

University of Michigan, Koutmos Lab

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Workshop / Seminar Fri, 16 Sep 2022 11:53:03 -0400 2022-09-30T10:00:00-04:00 2022-09-30T11:00:00-04:00 Life Sciences Institute U-M Structural Biology Workshop / Seminar KY Seminar Flier
DCMB / CCMB Weekly Seminar (October 5, 2022 4:00pm) https://events.umich.edu/event/99751 99751-21798643@events.umich.edu Event Begins: Wednesday, October 5, 2022 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract:

Accurately predicting the onset of disease is a major challenge in clinical medicine because the genesis of diseases is generally a complex and dynamic process. Wearable sensor technologies provide an unprecedented opportunity to collect physiological data at orders of magnitude higher high time-resolution than conventional clinical practice. This provides unprecedented opportunities for investigating the dynamics of disease processes and may usher in a new era of real-time, personalized medicine. We have proposed the potential of real-time, continuously measured physiological data as a non-invasive, “digital biomarker” approach for detecting the earliest stages in transition to a disease state. In this talk, I will describe an example of our interdisciplinary team’s work on this topic that uses the early detection and possible prediction of febrile (i.e., fever-associated) adverse events in cancer events as an important application.

Clinical Interests
Prostate Cancer, General Oncology, Biomarkers in Oncology
Research Interests
• Biology of circulating, extracellular nucleic acids and translational applications
• Developing next generation approaches for early detection and monitoring of cancer
• Bioinformatics and computational biology, high-throughput sequencing
• New technologies to enable cancer detection and monitoring

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

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Lecture / Discussion Mon, 03 Oct 2022 15:21:48 -0400 2022-10-05T16:00:00-04:00 2022-10-05T17:00:00-04:00 Palmer Commons DCMB Seminar Series Lecture / Discussion Muneesh Tewari, MD, PhD
Novel Structure of a Type I Polyketide Synthase Reductive Cassette (October 7, 2022 10:00am) https://events.umich.edu/event/98739 98739-21797130@events.umich.edu Event Begins: Friday, October 7, 2022 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

University of Michigan, Smith Lab

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Workshop / Seminar Fri, 16 Sep 2022 11:52:27 -0400 2022-10-07T10:00:00-04:00 2022-10-07T11:00:00-04:00 Life Sciences Institute U-M Structural Biology Workshop / Seminar TC Seminar Flier
Poster Design Workshop (October 11, 2022 4:00pm) https://events.umich.edu/event/99872 99872-21798816@events.umich.edu Event Begins: Tuesday, October 11, 2022 4:00pm
Location: Biological Sciences Building
Organized By: Futures in Research, Science, Teaching - FIRST

A short presentation on STEM poster design, followed by researchers and graduate students sharing personal examples. Topics will included formatting, narrating your research story, and designing a poster that works equally well presented or read on its own.

RSVP: https://forms.gle/DVGvnsSXhtCEBeWy6

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Workshop / Seminar Wed, 05 Oct 2022 13:46:21 -0400 2022-10-11T16:00:00-04:00 2022-10-11T17:00:00-04:00 Biological Sciences Building Futures in Research, Science, Teaching - FIRST Workshop / Seminar FIRST Logo
DCMB / CCMB Weekly Seminar (October 12, 2022 4:00pm) https://events.umich.edu/event/99377 99377-21797973@events.umich.edu Event Begins: Wednesday, October 12, 2022 4:00pm
Location: Palmer Commons
Organized By: DCMB Seminar Series

Abstract:

Our current understanding of how genes are regulated is akin to solving a jigsaw puzzle. Many factors governing gene expression have been identified, and researchers have collected a wide variety of related datasets. However, how these "parts" are pieced together to function as a whole remains unclear. In this talk, I will discuss our research to develop and apply state-of-the-art machine learning methods to genomics datasets to attempt to put together the pieces from the data. I will cover our work using deep learning architecture that captures the data's underlying structure to integrate datasets and connect them to gene expression via the prediction task. We also interpret the prediction results and tie them back to contributing factors to develop potential hypotheses related to gene regulation. I will then move from bulk data to the single-cell data domain and discuss methods to perform unsupervised integration of different types of single-cell experiments. This talk aims to highlight our research direction's potential to reveal the important gene regulatory mechanisms in characterizing cell types and diseases from the collected data.

Bio:

Ritambhara Singh is an Assistant Professor in the Computer Science department and a faculty member of the Center for Computational Molecular Biology at Brown University. Her research lab works at the intersection of machine learning and biology. Prior to joining Brown, Singh was a post-doctoral researcher in the Noble Lab at the University of Washington. She completed her Ph.D. in 2018 from the University of Virginia with Dr. Yanjun Qi as her advisor. Her research has involved developing machine learning algorithms for the analysis of biological data as well as applying deep learning models to novel biological and biomedical applications. She recently received the NHGRI Genomic Innovator Award for developing deep learning methods to integrate and model genomics datasets. URL: https://vivo.brown.edu/display/rsingh47

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Lecture / Discussion Tue, 27 Sep 2022 09:32:07 -0400 2022-10-12T16:00:00-04:00 2022-10-12T17:00:00-04:00 Palmer Commons DCMB Seminar Series Lecture / Discussion Ritambhara Singh, Asst. Professor (Brown University)
Celebrate Invention (October 13, 2022 1:00pm) https://events.umich.edu/event/98346 98346-21796522@events.umich.edu Event Begins: Thursday, October 13, 2022 1:00pm
Location: Michigan Union
Organized By: Innovation Partnerships

Celebrate University of Michigan inventors and the growing impact of U-M innovations!

Don’t miss this year’s annual Celebrate Invention highlighting demonstrations from promising U-M startups, networking opportunities at the ecosystem fair, panel discussions featuring prominent inventors and alumni, and the presentation of the Distinguished University Innovator of the Year Award.

Thursday, October 13
1:00–6:00pm
Michigan Union, 2nd Floor
530 S. State Street, Ann Arbor, MI 48109

Part of Ann Arbor SPARK's a2Tech360, Celebrate Invention is free and open to the public. Register today at *https://myumi.ch/DJNbM!*

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1:00–3:00pm: Panel Sessions & Ecosystem Fair

3:00–6:00pm: Reception, Rogel Ballroom, Michigan Union, 2nd Floor

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Reception / Open House Thu, 08 Sep 2022 17:06:20 -0400 2022-10-13T13:00:00-04:00 2022-10-13T18:00:00-04:00 Michigan Union Innovation Partnerships Reception / Open House Image of the Celebrate Invention logo on a blue background.
The "structural" journey of a ribonucleoprotein complex: From molecules to droplets (October 14, 2022 10:00am) https://events.umich.edu/event/98740 98740-21797131@events.umich.edu Event Begins: Friday, October 14, 2022 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

University of Michigan, Bardwell Lab

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Workshop / Seminar Fri, 23 Sep 2022 07:33:24 -0400 2022-10-14T10:00:00-04:00 2022-10-14T11:00:00-04:00 Life Sciences Institute U-M Structural Biology Workshop / Seminar RM Seminar Flier
Capturing native and intermediate states at atomic resolution by cryoEM (October 18, 2022 12:00pm) https://events.umich.edu/event/98203 98203-21795709@events.umich.edu Event Begins: Tuesday, October 18, 2022 12:00pm
Location: Medical Science Unit I
Organized By: U-M Structural Biology

UCLA

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Workshop / Seminar Fri, 07 Oct 2022 08:51:33 -0400 2022-10-18T12:00:00-04:00 2022-10-18T13:00:00-04:00 Medical Science Unit I U-M Structural Biology Workshop / Seminar
Advanced methods in cryogenic correlative light and electron microscopy: from super-resolution to fluorescent biosensors (October 25, 2022 12:00pm) https://events.umich.edu/event/98204 98204-21795711@events.umich.edu Event Begins: Tuesday, October 25, 2022 12:00pm
Location: Medical Science Unit I
Organized By: U-M Structural Biology

Stanford/SLAC

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Workshop / Seminar Wed, 07 Sep 2022 09:28:20 -0400 2022-10-25T12:00:00-04:00 2022-10-25T13:00:00-04:00 Medical Science Unit I U-M Structural Biology Workshop / Seminar
Writing Personal and Academic Statements (October 25, 2022 4:00pm) https://events.umich.edu/event/100505 100505-21800018@events.umich.edu Event Begins: Tuesday, October 25, 2022 4:00pm
Location: Biological Sciences Building
Organized By: Futures in Research, Science, Teaching - FIRST

Bioscience postdocs and grad students will give a presentation on what to include/avoid and how to frame your story while writing academic and personal statements for research-based grad programs (and others). There will be a chance after for anyone interested in workshopping their statement drafts in small groups.

RSVP: https://forms.gle/43KP9utUYjCknofm8

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Workshop / Seminar Thu, 20 Oct 2022 12:54:49 -0400 2022-10-25T16:00:00-04:00 2022-10-25T17:30:00-04:00 Biological Sciences Building Futures in Research, Science, Teaching - FIRST Workshop / Seminar FIRST Logo
Single Particle Cryo-EM of TRPV1: From Atomic Structures to Gating Mechanism (November 1, 2022 12:00pm) https://events.umich.edu/event/98205 98205-21795716@events.umich.edu Event Begins: Tuesday, November 1, 2022 12:00pm
Location: Medical Science Unit I
Organized By: U-M Structural Biology

UCSF

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Workshop / Seminar Wed, 07 Sep 2022 09:28:49 -0400 2022-11-01T12:00:00-04:00 2022-11-01T13:00:00-04:00 Medical Science Unit I U-M Structural Biology Workshop / Seminar
Structural insights into the mitochondrial B12 trafficking pathway (November 4, 2022 10:00am) https://events.umich.edu/event/98743 98743-21797134@events.umich.edu Event Begins: Friday, November 4, 2022 10:00am
Location: Life Sciences Institute
Organized By: U-M Structural Biology

University of Michigan, Banerjee Lab

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Workshop / Seminar Fri, 07 Oct 2022 08:54:11 -0400 2022-11-04T10:00:00-04:00 2022-11-04T11:00:00-04:00 Life Sciences Institute U-M Structural Biology Workshop / Seminar RM Seminar Flier
Professor Career Path (November 22, 2022 4:00pm) https://events.umich.edu/event/101249 101249-21801109@events.umich.edu Event Begins: Tuesday, November 22, 2022 4:00pm
Location: Biological Sciences Building
Organized By: Futures in Research, Science, Teaching - FIRST

This seminar will cover the career path of STEM professors beginning with undergraduate research. Professor Monica Dus of the MCDB department will share her experiences starting in undergrad research, through earning a PhD, working as a post-doctoral researcher, and eventually starting her own research lab at the University of Michigan. Prof. Dus studies nutrigenomics, which looks at how genes interact with our diet to shape neural plasticity and feeding behavior.

RSVP: https://docs.google.com/forms/d/e/1FAIpQLSeJe8DfFZVUeqqguF_u_tNBzZwlU-nj6il4-TkwjVgRXBEfug/viewform?usp=sf_link

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Workshop / Seminar Thu, 17 Nov 2022 14:25:15 -0500 2022-11-22T16:00:00-05:00 2022-11-22T17:00:00-05:00 Biological Sciences Building Futures in Research, Science, Teaching - FIRST Workshop / Seminar FIRST Logo