Happening @ Michigan https://events.umich.edu/list/rss RSS Feed for Happening @ Michigan Events at the University of Michigan. Diagnosing disease on a microchip: Finding nanoscale needles in a nanoscale haystack (March 30, 2023 3:30pm) https://events.umich.edu/event/106711 106711-21814734@events.umich.edu Event Begins: Thursday, March 30, 2023 3:30pm
Location: Cooley Building
Organized By: Biomedical Engineering

Abstract: The transformative growth in microelectronics in the latter half of the 20th century was fueled fundamentally by the ability to miniaturize complex circuits onto chips. The impact of this has been profound– computing is pervasive and portable and communication is instant and global. My research aims to harness this same engineering approach to solve high impact problems in medical diagnostics. To accomplish this goal my lab develops hybrid microchips, where microfluidics are built directly on top of semiconductor chips. In this talk I will focus on recent work at Penn on 'digital asays.' Digital assays — in which ultra-sensitive molecular measurements are made by performing millions of parallel experiments in picoliter droplets — have generated enormous enthusiasm due to their single molecule resolution. These assays have incredible untapped potential for disease diagnostics but are currently confined to laboratory settings due to the instrumentation necessary to generate, control, and measure tens of millions of droplets. To overcome this challenge, we are developing a hybrid microelectronic / microfluidic chip to ‘unlock’ droplet-based assays for mobile use. Our microDroplet Fluorescence Detector (µDFD) takes inspiration from cellular networks, in which phones are identified by their carrier frequency and not their particular location. In collaboration with physicians at The Abramson Cancer Center, we are demonstrating the power of this approach by developing a multiplexed exosome-based diagnostic for the early detection of pancreatic cancer.

Bio: The Issadore lab combines microelectronics, microfluidics, nanomaterials, and machine learning to solve big problems in healthcare. We create miniaturized platforms for the diagnosis of disease, we develop new platforms to manufacture micro and nanomaterials, and we dip our toes into an assortment of other areas where we can leverage our engineering training to improve healthcare. This work requires an interdisciplinary approach in which engineers, scientists, and physicians work together in teams.

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Workshop / Seminar Sat, 25 Mar 2023 18:10:52 -0400 2023-03-30T15:30:00-04:00 2023-03-30T16:30:00-04:00 Cooley Building Biomedical Engineering Workshop / Seminar BME Seminar Series
Hallucinations and objective assessments of deep learning technologies for medical image formation (April 6, 2023 3:30pm) https://events.umich.edu/event/107076 107076-21815261@events.umich.edu Event Begins: Thursday, April 6, 2023 3:30pm
Location: Cooley Building
Organized By: Biomedical Engineering

Abstract:
A variety of deep learning-based image restoration and reconstruction methods, generically referred to as image formation methods, have been proposed for use with biomedical images. It is widely accepted that the assessment and refinement of biomedical imaging technologies should be performed by objective, i.e., task-based, measures of image quality (IQ). However, the objective evaluation of deep learning-based image formation technologies remains largely lacking, despite the breakneck speed at which they are being developed. As such, there is an ever-growing collection of methods whose utility and trustworthiness remains largely unknown. Moreover, such methods have the capability to ‘hallucinate’ false structures, which is of significant concern in medical imaging applications. In this work, we report studies in which the performance of deep learning-based image restoration methods is objectively assessed. The performance of the ideal observer (IO) and common linear numerical observers are quantified, and detection efficiencies are computed to assess the impact of deep learning image formation methods on signal detection performance. The numerical results indicate that, in the cases considered, the application of a deep image formation network can result in a loss of task-relevant information in the image, despite improvement in traditional computer-vision metrics. We also demonstrate that traditional and objective IQ measures can vary in opposite ways as a function of network depth. These results highlight the need for the objective evaluation of IQ for deep image formation technologies and may suggest future avenues for improving the effectiveness of medical imaging applications. 

Bio:
Dr. Mark Anastasio is the Donald Biggar Willett Professor in Engineering and the Head of the Department of Bioengineering at the University of Illinois at Urbana-Champaign (UIUC). Before joining UIUC in 2019, he was a Professor of Biomedical Engineering at Washington University in St. Louis, where he established one of the nation’s first stand-alone PhD programs in imaging science. Dr. Anastasio’s research accomplishments to the fields of biomedical imaging and image science have been numerous and impactful and his general interests broadly address the computational aspects of image formation, modern imaging science, and applied machine learning. He has conducted research in the fields of diffraction tomography, X-ray phase-contrast imaging, and ultrasound tomography. He one of the world’s leading authorities on photoacoustic computed tomography (PACT) and has made numerous and important contributions to development of PACT for over fifteen years. He has published over 175 peer-reviewed journal papers in leading imaging and optical science journals and was the recipient of a National Science Foundation (NSF) CAREER Award to develop image reconstruction methods. He is a Fellow of the American Institute for Medical and Biological Engineering (AIMBE), the International Academy of Medical and Biological Engineering (IAMBE) and the SPIE. He also served as the Chair of the NIH BMIT-B and EITA Study Sections.

Zoom:
https://umich.zoom.us/j/91712262512

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Workshop / Seminar Fri, 31 Mar 2023 14:53:29 -0400 2023-04-06T15:30:00-04:00 2023-04-06T16:30:00-04:00 Cooley Building Biomedical Engineering Workshop / Seminar BME Seminar Series
2023 Biomedical Engineering Symposium with Glenn V. Edmonson Lecture (May 4, 2023 10:00am) https://events.umich.edu/event/107592 107592-21816243@events.umich.edu Event Begins: Thursday, May 4, 2023 10:00am
Location: North Campus Research Complex Building 18
Organized By: Biomedical Engineering

The 2023 Biomedical Engineering Symposium with Glenn V. Edmonson Lecture is intended to build the BME community across campus and honor the legacy of the first graduate chair of the Biomedical Engineering program. These events will provide a forum for BME faculty and students campus-wide along with our collaborators to present current research progress and discuss future research opportunities at the interface of engineering and medicine.

Featuring Glenn V. Edmonson Lecture speaker
Naomi Chesler
Chancellor's Inclusive Excellence Professor
Department of Biomedical Engineering University of California, Irvine
Director of the University of California Irvine
Edwards Lifesciences Foundation
Cardiovascular Innovation & Research Center

The events will take place on Thursday, May 4th, from 10:00 AM - 5:00 PM at NCRC, Bldg 18, Dining Hall. Please RSVP by Thursday, April 27th, 2023.

https://forms.gle/9BivDqH4uh4Wvphn9

Questions: Contact bmesymposium2023@umich.edu

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Lecture / Discussion Fri, 14 Apr 2023 09:58:33 -0400 2023-05-04T10:00:00-04:00 2023-05-04T17:00:00-04:00 North Campus Research Complex Building 18 Biomedical Engineering Lecture / Discussion BME Symposium
BME Summer Workshops @ Michigan (August 11, 2023 2:00pm) https://events.umich.edu/event/109859 109859-21823106@events.umich.edu Event Begins: Friday, August 11, 2023 2:00pm
Location: North Campus Research Complex Building 10
Organized By: Biomedical Engineering

The BME Summer Workshop @ Michigan, titled “Imaging and Therapy in Vision Research 2023,” is happening August 11-12, 2023, at NCRC Building 10, South Atrium.

This event, co-hosted by U-M BME and Ophthalmology and Visual Sciences, will provide a platform for discussing common research interests in diagnosis and treatment of pathologic conditions associated with the eye and the brain.

Featured guest speakers will include Dr. Joseph Izatt, the Michael J. Fitzpatrick Distinguished Professor of Engineering and Chair, Biomedical Engineering Department, Duke University; Dr. Xincheng Yao, the Richard and Loan Hill Professor from the University of Illinois at Chicago; Dr. Juliette E. McGregor, Assistant Professor at the University of Rochester, and Dr. Salavat Aglyamov, Research Assistant Professor from the University of Houston.

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Workshop / Seminar Sat, 05 Aug 2023 07:52:02 -0400 2023-08-11T14:00:00-04:00 2023-08-11T20:30:00-04:00 North Campus Research Complex Building 10 Biomedical Engineering Workshop / Seminar Imaging and Therapy in Vision Research 2023
BME Summer Workshops @ Michigan (August 12, 2023 8:00am) https://events.umich.edu/event/109859 109859-21823107@events.umich.edu Event Begins: Saturday, August 12, 2023 8:00am
Location: North Campus Research Complex Building 10
Organized By: Biomedical Engineering

The BME Summer Workshop @ Michigan, titled “Imaging and Therapy in Vision Research 2023,” is happening August 11-12, 2023, at NCRC Building 10, South Atrium.

This event, co-hosted by U-M BME and Ophthalmology and Visual Sciences, will provide a platform for discussing common research interests in diagnosis and treatment of pathologic conditions associated with the eye and the brain.

Featured guest speakers will include Dr. Joseph Izatt, the Michael J. Fitzpatrick Distinguished Professor of Engineering and Chair, Biomedical Engineering Department, Duke University; Dr. Xincheng Yao, the Richard and Loan Hill Professor from the University of Illinois at Chicago; Dr. Juliette E. McGregor, Assistant Professor at the University of Rochester, and Dr. Salavat Aglyamov, Research Assistant Professor from the University of Houston.

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Workshop / Seminar Sat, 05 Aug 2023 07:52:02 -0400 2023-08-12T08:00:00-04:00 2023-08-12T12:00:00-04:00 North Campus Research Complex Building 10 Biomedical Engineering Workshop / Seminar Imaging and Therapy in Vision Research 2023
Biomedical Engineering Seminar Series (August 31, 2023 4:30pm) https://events.umich.edu/event/110517 110517-21825007@events.umich.edu Event Begins: Thursday, August 31, 2023 4:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Abstract:
Systems neuroscience is now tackling higher-dimensional spaces as we record from larger neural populations, examine richer behavioral repertoires, and place animals in more complex environments. Combined with precise stimulation technologies, we can begin to dissect large-scale circuits in vivo, constructing models that causally relate neural activity to behavior. Perturbative testing of hypothesized brain-behavior links, however, requires statistically efficient methods for both estimating and intervening on neural activity in real time. Here I will discuss a few ways in which we can construct and refine models built in real-time, as neural or behavioral data are acquired, and use them to ‘close the loop’ and determine the optimal next stimulus to present or optimal next neuronal perturbation to apply. We demonstrate these methods in simulation and in experiments studying the optomotor response in larval zebrafish with calcium fluorescence imaging.

Bio:
Dr. Anne Draelos is an Assistant Professor in Biomedical Engineering and Computational Medicine & Bioinformatics at the University of Michigan. Her lab is focused on machine learning and statistical techniques to facilitate real-time analysis of high-dimensional neural and behavioral data. Anne obtained her PhD in physics and underwent postdoctoral training in neuroscience at Duke University. She currently holds a Career Award at the Scientific Interface from the Burroughs Wellcome Fund.

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Workshop / Seminar Mon, 21 Aug 2023 08:28:17 -0400 2023-08-31T16:30:00-04:00 2023-08-31T17:30:00-04:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar A speaker talking to a group of students in a classroom.
Biomedical Engineering Seminar Series (September 7, 2023 4:30pm) https://events.umich.edu/event/111217 111217-21826267@events.umich.edu Event Begins: Thursday, September 7, 2023 4:30pm
Location: Lurie Biomedical Engineering (formerly ATL)
Organized By: Biomedical Engineering

Abstract:
Drug-eluting stents (DES) revolutionized the treatment of coronary artery disease and became one of the fastest growing medical device markets in history. Beginning in the early 2000s, the next two decades brought rapid innovation, hyper-competition, and, eventually, market maturation. Via an interactive discussion, we’ll seek to understand the role of different stakeholders, drivers of market competitiveness, and evolving strategies as the market progressed.

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Workshop / Seminar Wed, 30 Aug 2023 17:24:11 -0400 2023-09-07T16:30:00-04:00 2023-09-07T18:00:00-04:00 Lurie Biomedical Engineering (formerly ATL) Biomedical Engineering Workshop / Seminar A speaker talking to a group of students in a classroom.
Biomedical Engineering Seminar Series (September 14, 2023 4:30pm) https://events.umich.edu/event/111280 111280-21826619@events.umich.edu Event Begins: Thursday, September 14, 2023 4:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Abstract:
Our lab integrates biomolecular engineering, biomaterials, and bioanalytical chemistry approaches to address therapeutic and diagnostic challenges across cancer and other diseases. In the therapeutics arena, RNA is experiencing a renaissance since the recent clinical successes of the COVID-19 mRNA vaccines. By leveraging the sequence and structural versatilities of RNA, we engineer multifunctional RNA macromolecules as genetic tools, immunomodulatory materials, and generic building blocks. Towards overcoming analytical barriers in clinical diagnostics, I will highlight work in developing and translating ultrasensitive single-molecule detection technologies for measuring low abundance protein biomarkers.

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Workshop / Seminar Thu, 31 Aug 2023 11:40:41 -0400 2023-09-14T16:30:00-04:00 2023-09-14T17:30:00-04:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar A speaker talking to a group of students in a classroom.
Engineering Education Research Seminar (September 21, 2023 2:30pm) https://events.umich.edu/event/112519 112519-21829073@events.umich.edu Event Begins: Thursday, September 21, 2023 2:30pm
Location: Duderstadt Center
Organized By: Biomedical Engineering

Science and engineering are increasingly multidisciplinary. Many researchers encounter career challenges when adopting methods from fields outside their formal training. For example, faculty who shift disciplines need to acquire new skills while fulfilling their mentoring responsibilities to students who join them in the new field. We used collaborative autoethnography to study a tripartite mentoring relationship between an experienced engineering education researcher and two novice education researchers who have backgrounds in engineering—a biomedical engineering faculty member and graduate student. Using data from written reflections and interviews, we explored the role of instrumental and psychosocial supports in our mentoring relationship. We noted how elements of cognitive apprenticeship such as scaffolding and gradual fading of instrumental supports helped novices learn qualitative research skills that differed drastically from their biomedical engineering research expertise. While our mentoring relationship was overall very positive, it has included many moments of miscommunication and misunderstanding. We draw on Lent and Lopez’s idea of relation-inferred self-efficacy to explain some of these missed opportunities for communication and understanding. Our initial mentoring model failed to consider how challenging it is for mentees to make the paradigm shift from technical engineering to social science research and how that would affect a faculty member’s ability to mentor students in a new field. Our experiences have implications for expanding research capacity because they raise practical and conceptual issues for experienced and novice researchers to consider as they form mentoring relationships.

BIOGRAPHICAL SKETCH: Dr. Paul Jensen an assistant professor of biomedical engineering at the University of Michigan, where he mentors students in systems microbiology, artificial intelligence, and automated science. Paul trained as an engineer and microbiologist at the University of Minnesota, the University of Virginia, and Boston College. He is an ASQ Certified Quality Engineer and co-founder of the biotech company Cerillo, Inc. In 2020, Paul received the Stanley H. Pierce Faculty Award for developing empathetic student-faculty relationships.

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Workshop / Seminar Sat, 16 Sep 2023 14:59:32 -0400 2023-09-21T14:30:00-04:00 2023-09-21T15:30:00-04:00 Duderstadt Center Biomedical Engineering Workshop / Seminar Duderstadt Center
Biomedical Engineering Seminar Series (September 21, 2023 4:30pm) https://events.umich.edu/event/112629 112629-21829204@events.umich.edu Event Begins: Thursday, September 21, 2023 4:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Abstract:
The primary barrier for clinical translation of nanomedicines remains delivery to target tissues in vivo. Upon intravenous (IV) administration, vehicles encounter extracellular and intracellular barriers. It is also unclear how NP design features impact physiological interactions with biological systems, highlighting the need for studies that elucidate these structure-function relationships. In this seminar, I will describe our work on developing polymeric nanoparticles (NPs) to deliver therapeutic nucleic acids to a variety of tissues following systemic IV administration. We found that gene therapy can be significantly enhanced using a new class of polymeric vehicles consisting of poly(amine-co-ester) (PACE) polymers that are designed for safe and effective nucleic acid delivery. We have also developed tools to study nanomaterial-biology interactions in animal models. I will describe our robust high-throughput quantitative microscopy-based platform to standardize and accelerate the analysis of circulation half-life and biodistribution of nanomedicines to facilitate pre-clinical screening in vivo. This tool, alongside the development of novel polymeric carriers, can be used to study the structure-function relationships that guide the physiological fate of NPs in order to rationally design more effective delivery vehicles for future applications.

Bio:
Dr. Alexandra S. Piotrowski-Daspit, Ph.D. is an Assistant Professor of Biomedical Engineering and Internal Medicine – Pulmonary and Critical Care Medicine Division at the University of Michigan. Dr. Piotrowski-Daspit received her bachelor’s degree in Chemical-Biological Engineering and Biology from the Massachusetts Institute of Technology (MIT) and her Ph.D. in Chemical & Biological Engineering from Princeton University. She trained as a postdoctoral fellow at Yale University, and has received funding from the NIH (NHLBI K99/R00 Pathway to Independence Award) and the Cystic Fibrosis Foundation (Postdoc-to-Faculty Transition Award) to support her interdisciplinary research in chemical/biomedical engineering, biomaterials, genetics, and drug delivery to develop therapeutic strategies to treat hereditary disorders with a focus on lung diseases.

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Workshop / Seminar Mon, 18 Sep 2023 15:59:09 -0400 2023-09-21T16:30:00-04:00 2023-09-21T17:30:00-04:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar A speaker talking to a group of students in a classroom.
Biomedical Engineering Seminar Series (September 28, 2023 4:30pm) https://events.umich.edu/event/113073 113073-21829989@events.umich.edu Event Begins: Thursday, September 28, 2023 4:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Abstract:

Heart disease is the leading cause of death in the developed world and is often characterized by changes in cellular scale mechanics that drive changes in heart structure and function. Hypertrophic cardiomyopathy is a specific genetic form of heart disease caused by mutations in the proteins responsible for muscle contraction (myosin), and study of these mutations have revealed surprising heterogeneity of effects that can complicate the development of therapies. The Vander Roest lab uses several innovative molecular, cellular, bioengineering, and computational modeling tools to examine and contextualize the role of altered cellular mechanics in driving changes in cardiac cell phenotypes. CRISPR/Cas9 gene editing in human induced pluripotent stem cells provides a model system to investigate the effects of specific mutations in a dynamic cellular context. Micropatterned engineered platforms will be used to improve myofibril alignment and allow direct measurement of intracellular force production by traction force microscopy. and the Vander Roest lab can study the impact of these mutations using stem cell derived cardiomyocytes. We use traction force microscopy and tension sensor FRET imaging to measure forces generated by these cells and relate these altered mechanics to disease phenotypes. We also use computational modeling to understand how altered forces are generated from myosin are propagated from the molecular to cellular to tissue scale. Understanding disease mechanisms and the heterogeneity of phenotypes across multiple scales (molecular, cellular, and clinical) will enable the development of better and more individualized therapies for patients with HCM.

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Workshop / Seminar Mon, 25 Sep 2023 18:52:48 -0400 2023-09-28T16:30:00-04:00 2023-09-28T17:30:00-04:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar A speaker talking to a group of students in a classroom.
Biomedical Engineering Seminar Series (October 5, 2023 4:30pm) https://events.umich.edu/event/113383 113383-21830905@events.umich.edu Event Begins: Thursday, October 5, 2023 4:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Abstract:
There are profound deficits in how humans, and adults in particular, heal and recover from tissue damage. The alternative to productive tissue healing is the formation of dysfunctional scaring, which underlies chronic degenerative arthritic conditions, chronic autoimmune diseases and the fibrosis associated with the foreign body response to implants. Our clinical translation experiences in orthopedics and plastic surgery yielded the unexpected discovery of adaptive immune cells in the biomaterial response. Distinct pathways of adaptive immunity, T cells together with linked activity of innate lymphocytes, regulate productive versus destructive tissue responses and should therefore be the primary targets of regenerative medicine. Recent data further implicate cellular senescence as a major therapeutically targetable player in local tissue-destructive immune responses and fibrosis. Understanding and subsequent manipulation of the local tissue microenvironment with regenerative immunotherapies and biomaterials is a mechanism by which the effector class and T cell function and senescence can be engaged. We are now working to understand the role of the immune system and cellular senescence in the biomaterial response and repair across different tissues across lifespan.
Bio:
Dr. Elisseeff is the Morton Goldberg Professor and Founder of the Translational Tissue Engineering Center at Johns Hopkins Department of Biomedical Engineering and the Wilmer Eye Institute and is Interim Chair of the Department of Chemical and Biomolecular Engineering. She was elected a Fellow of the American Institute of Medical and Biological Engineering, the National Academy of Inventors, a Young Global Leader by World Economic Forum. In 2018, she was elected to the National Academy of Engineering and National Academy of Medicine and in 2019 she received the NIH Directors Pioneer Award. In 2022 she was elected as a fellow of the American Academy of Arts and Sciences and in 2023 a member of the National Academy of Sciences.

Zoom:
https://umich.zoom.us/j/99085426766

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Workshop / Seminar Mon, 02 Oct 2023 14:54:46 -0400 2023-10-05T16:30:00-04:00 2023-10-05T17:30:00-04:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar A speaker talking to a group of students in a classroom.
Biomedical Engineering Seminar Series (October 19, 2023 4:30pm) https://events.umich.edu/event/114040 114040-21832241@events.umich.edu Event Begins: Thursday, October 19, 2023 4:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Sentinel Biomaterials in Alloimmunity: Transplant and Prenatal Care
DUE TO ILLNESS, Dr. Whitehead will be rescheduled for a future date

Abstract:
As there is no assay to predict alloimmunity in transplant or fetal rejection, clinicians rely on invasive tissue biopsy, non-specific blood-based assays, and, in transplant, aggressive immunosuppression. Primary tissue histology is a flawed standard for alloimmunity surveillance, as histological evidence of rejection inherently lags behind molecular biomarkers of alloimmunity. A minimally invasive surveillance method is needed to identify early risk of rejection for minimizing invasive procedures and personalizing interventions. We have developed biomaterial scaffolds for minimally-invasive sampling. These scaffolds amass immune cells producing biomarkers of disease as an engineered niche which can predict rejection onset. In this work, we employ biomaterials as sentinels to capture the longitudinal immune domain of healthy and rejecting transplants and healthy and miscarriage-prone rodent pregnancies without disrupting the primary tissue and with greater specificity than blood.

Bio:
Dr. Russell Urie is a postdoctoral fellow here at the University of Michigan with Professor Lonnie Shea, developing tissue engineering scaffolds for immunosurveillance of transplant rejection and prenatal complications. Prior to his postdoc, he obtained his PhD with Dr. Kaushal Rege in Chemical Engineering from Arizona State University, where his research centered on the creation of stimulus-responsive nanomaterials for tissue repair. Throughout his academic journey, Russell has received several accolades for his research and teaching contributions. Moreover, he has demonstrated a strong commitment to mentoring undergraduate and graduate students in their research pursuits.​​​​​​​

Zoom:
https://umich.zoom.us/j/99085426766

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Workshop / Seminar Wed, 18 Oct 2023 18:49:44 -0400 2023-10-19T16:30:00-04:00 2023-10-19T17:30:00-04:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar A speaker talking to a group of students in a classroom.
Biomedical Engineering Seminar Series (October 26, 2023 4:30pm) https://events.umich.edu/event/114383 114383-21832817@events.umich.edu Event Begins: Thursday, October 26, 2023 4:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Abstract:
Engineered extracellular matrices (ECMs) are important for cellular therapies and tissue engineering applications; however, synthetic ECMs remain less structurally and biologically complex than natural ECM. In particular, the native ECM is composed of hierarchically structured biopolymers with dynamic properties that change over time. Synthetic ECMs, however, are typically formed from disordered polymers and chemistries that lead to time-invariant properties. Toward this end, we have developed bioinspired strategies to incorporate hierarchical order and dynamic behavior into synthetic hydrogels. We will discuss the chemical and physical mechanisms that lead to multiscale control in these materials, as well as their application toward matrices for human mesenchymal stromal cell culture.
Bio:
Dr. Adrianne Rosales is an Assistant Professor of Chemical Engineering at the University of Texas at Austin. She is a co-lead of the Interdisciplinary Research Group “Fuel-Driven Pluripotent Materials” in UT Austin’s Materials Research Science and Engineering Center. She received her B.S. in Chemical Engineering from UT Austin and obtained her Ph.D. in Chemical Engineering from UC Berkeley. After completing her Ph.D. in 2013, she trained at the University of Colorado Boulder as an NIH NRSA post-doctoral fellow. Adrianne's group at UT Austin focuses on the development of bioinspired polymeric materials to model cellular microenvironments and engineer therapeutic technologies. This work has received emerging investigator recognitions from the Burroughs Wellcome Fund, the NIH, the NSF, and the American Chemical Society Polymeric Materials: Science and Engineering Division.

Zoom:
https://umich.zoom.us/j/99085426766

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Workshop / Seminar Tue, 24 Oct 2023 12:36:25 -0400 2023-10-26T16:30:00-04:00 2023-10-26T17:30:00-04:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar A speaker talking to a group of students in a classroom.
U-M Biomedical Engineering Virtual PhD Application Webinar (November 2, 2023 1:00pm) https://events.umich.edu/event/114310 114310-21832647@events.umich.edu Event Begins: Thursday, November 2, 2023 1:00pm
Location: Off Campus Location
Organized By: Biomedical Engineering

Learn about the PhD application process during this live three-hour webinar. Use the link or QR code to register and receive the link to attend.

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Livestream / Virtual Sat, 21 Oct 2023 11:03:58 -0400 2023-11-02T13:00:00-04:00 2023-11-02T16:00:00-04:00 Off Campus Location Biomedical Engineering Livestream / Virtual Images of BME with a QR Code to Register for the Webinar
Alan J. Hunt Memorial Lecture-U-M Biomedical Engineering (November 3, 2023 3:00pm) https://events.umich.edu/event/113716 113716-21831489@events.umich.edu Event Begins: Friday, November 3, 2023 3:00pm
Location:
Organized By: Biomedical Engineering

Abstract:
Total joint replacements (TJR) restore pain-free mobility and function to damaged or diseased cartilage in the articular joints using engineering materials. These load-bearing implant systems typically comprise metal-on-polymer couplings. There are nearly one million total joint replacement surgeries performed annually in the United States with CoCr alloys articulating against ultra-high molecular weight polyethylene (UHMWPE) comprising the majority of hip, knee and shoulder replacements (American Academy of Orthopedic Surgeons, 2022). These medical devices must offer extraordinary resistance to wear, corrosion and fatigue loading. Approximately 12% of these devices require revision due to loosening, wear-mediated osteolysis (bone loss around the implant), fracture of components or failure of the bearing surfaces within their first decade of use.

Professor Pruitt and her lab have devoted nearly 30 years of research toward the understanding of the complex material behavior in total joint replacement designs. Her work has elucidated many of the primary failure mechanisms found in the bearing systems as well as the inherent trade-offs that exist in the fatigue, fracture, wear and oxidation resistance in orthopedic polymers, and most notably in UHMWPE. These failure schemes are complicated by stress concentrations required for locking mechanisms, joint articulation, fixation to surrounding tissues and features in the implants that facilitate retrieval of the device. Well-functioning implants offer 10-20 years of service but generally require at least one revision in the lifetime of a patient. Hence implants must enable a retrieval scheme that minimizes damage to surrounding tissues upon replacement of an implant - such challenges are ever-increasing as demographics shift to younger and more active patients.

Professor Pruitt’s ongoing research focuses on the characterization of structure-property relationships in orthopedic biomaterials in order to optimize systems for resistance to in-vivo fatigue, wear and oxidation in TJR. Professor Pruitt will also discuss how such research provides a pathway for inclusive excellence in teaching, research and mentoring.

Bio:
Lisa Pruitt, Ph.D., is Professor of Mechanical Engineering and Bioengineering at the University of California at Berkeley. Dr. Pruitt also is the Director of the Medical Polymer Group at the school. She received her Ph.D. from Brown University and joined the faculty of Mechanical Engineering at UC Berkeley in 1993.

Dr. Pruitt has authored more than 300 publications in her research field of failure analysis, biomaterials and medical devices. The recipient of numerous awards and honors, her research has been recognized with a Congressional citation; a National Science Foundation CAREER award; an Office of Naval Research Young Investigator Award; and election to the American Institute of Medical and Biological Engineering. Professor Pruitt has also been honored for her commitment to excellence in mentoring, teaching and outreach. She has received the American Association of Advancement of Sciences Mentoring Award; the Presidential Award for Excellence in Science, Mathematics and Engineering Mentoring; the UC Berkeley Distinguished Teaching Award as well as the Brown Engineering Alumni Medal.

Professor Pruitt teaches undergraduate and graduate courses in Mechanical Behavior of Engineering Materials, Failure Analysis, Polymer Engineering, Medical Device Design and Personal Leadership. Lisa Pruitt is the author of four books including Soul of a Professor: Memoir of an Un-engineered Life (Merry Dissonance Press, 2022); Mechanics of Biomaterials: Fundamentals for Implant Design (Cambridge University Press, 2011); Horse of Fire: The story of an extraordinary and Knowing Horse as told by JJ Luck (Authorhouse, 2008; Amazon, 2019); as well as a children’s book, Savanna and the Magic Boots (Authorhouse, 2011).

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Lecture / Discussion Mon, 09 Oct 2023 12:41:56 -0400 2023-11-03T15:00:00-04:00 2023-11-03T17:00:00-04:00 Biomedical Engineering Lecture / Discussion Alan J. Hunt and a quote from him
Biomedical Engineering Seminar Series (November 9, 2023 4:30pm) https://events.umich.edu/event/114850 114850-21833694@events.umich.edu Event Begins: Thursday, November 9, 2023 4:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Abstract:
Sleep apnea is associated with cardiovascular dysfunction which is linked to fatigability associated with activities of daily living. A well-established treatment modality (continuous positive airway pressure) is often ineffective in mitigating these co-morbidities. Thus, the development of novel treatments to eliminate apnea and mitigate associated co-morbidities is imperative. We are addressing this mandate by determining if repeated exposure to mild intermittent hypoxia (MIH) mitigates cardiovascular dysfunction and enhances performance fatigability. We propose that exposure to MIH has a multipronged effect. MIH directly targets cardiovascular co-morbidities, while simultaneously enhancing upper airway stability and increasing the arousal threshold. These modifications may serve to directly mitigate apnea. Alternatively, these modifications may serve to improve treatment adherence with continuous positive airway pressure. Independent of its effect, MIH may serve as an adjunctive therapy which provides another path to mitigating cardiovascular co-morbidities that might ultimately result in improvements in performance fatigability.

Bio:
Dr. Mateika is a respiratory physiologist who is presently investigating the impact of genetically or spinal cord injury induced reductions in central nervous system serotonin on mechanisms that influence breathing stability and cardiovascular/autonomic function in mice. Dr. Mateika is also exploring if repeated daily exposure to mild intermittent hypoxia independently or combined with continuous positive airway pressure mitigates co-morbidities (i.e. hypertension) linked to sleep apnea in humans.

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Workshop / Seminar Fri, 03 Nov 2023 10:37:09 -0400 2023-11-09T16:30:00-05:00 2023-11-09T17:30:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar A speaker talking to a group of students in a classroom.
Biomedical Engineering Seminar Series (November 16, 2023 4:30pm) https://events.umich.edu/event/115040 115040-21833965@events.umich.edu Event Begins: Thursday, November 16, 2023 4:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Abstract:
The intrinsic motion sensitivity of magnetic resonance imaging (MRI) can be used acquire and quantify blood flow in-vivo. Advances in imaging techniques allow the use of 4D flow MRI to measure, visualize and quantify 3D blood flow with full volumetric coverage of cardiac chambers or cardio- or neurovascular regions (e.g., thoracic aorta, large cerebral vessels). The complexity of the 4D flow MRI data (3 spatial dimension, 3 velocity directions, time) allows for the visualization of complex 3D blood flow patterns and the retrospective quantification of blood flow and derived hemodynamic parameters (e.g., wall shear stress, pressure gradients) which has facilitated insight into cardiovascular hemodynamics previously limited by other in-vivo imaging strategies. Specifically, quantitative flow analysis can provide information on the impact of cardio- or neurovascular pathologies on altered hemodynamics associated with disease progression and patient outcome.

This presentation will 1) introduce methodological aspects of 2D flow imaging with MRI and the state-of-the-art and recent developments related to 4D flow MRI; 2) describe clinical applications of cardiothoracic 4D flow MRI for the assessment of 3D flow dynamics in the heart and vessels that have demonstrated its potential for an improved assessment of cardiovascular disease, and 3) discuss recent developments such as 5D flow imaging and application of artificial intelligence and deep learning for improved analysis workflows.

Bio:

Dr. Markl is the Vice Chair for Research in the Department of Radiology at Northwestern University Feinberg School of Medicine. He is also the Lester B. and Frances T. Knight Professor of Cardiac Imaging in the Departments of Radiology and Biomedical Engineering at Northwestern University. He received his PhD in Physics from the University of Freiburg, Germany (2000), and served as a postdoctoral fellow at the Lucas MRI/S Center at Stanford University, Radiology (2001-2004). In 2004, he returned to the University Hospital in Freiburg, Germany as the Director of Cardiovascular MRI. Dr. Markl joined the Northwestern Radiology and BME faculty in 2011.

Dr. Markl's research program has had a major impact on the diagnosis and management of cardiovascular disease including the development of novel imaging techniques for the assessment of cardiac structure, function and hemodynamics, and discovery of mechanisms underlying cardiovascular diseases development and stroke. He is internationally recognized as the pioneer of 4D flow MRI and work in this area has advanced the understanding of cardiovascular disease processes as well as enhanced patient care.

To date, his accomplishments include a total of >380 peer-reviewed publications, 800+ conference abstracts, 29 invited review articles, 5 clinical guideline or consensus statement documents, 11 book chapters, 13 patents, and >180 invited presentation. In addition, Dr. Markl has a track-record of external funding with over 40 awarded grants from the NIH, societies, and industry collaborations. He has a record of mentorship having trained over 90 medical and graduate students, postdocs, clinical fellows, and junior faculty. These trainees have received prestigious awards from the NIH, AHA, ISMRM, RSNA, and others and have successful careers in academia and industry.

Dr. Markl is a recipient of the RSNA Research Trainee Prize, the I.I. Rabi Award Young Investigator Award of the ISMRM, and the Distinguished Investigator Award of the Academy of Radiology Research. He is an Associate Editor for 'Radiology - Cardiothoracic Imaging’, a Fellow of the ISMRM and SCMR, a member of the Executive Committee of the Board of Trustees (Vice-President) of the SCMR, and the Past-President-of the SMRA.

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Workshop / Seminar Wed, 08 Nov 2023 13:10:44 -0500 2023-11-16T16:30:00-05:00 2023-11-16T17:30:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar A speaker talking to a group of students in a classroom.
Biomedical Engineering Seminar Series (November 30, 2023 4:30pm) https://events.umich.edu/event/115357 115357-21834565@events.umich.edu Event Begins: Thursday, November 30, 2023 4:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Abstract:
The intervertebral disc (IVD) is an essential fibrocartilaginous joint in the spinal column that provides the shock absorption and weight distribution biomechanical properties of the spine. IVDs are complex, heterogeneous structures that are prone to cumulative damage overtime due to a limited regenerative capacity. The accrual of IVD injuries leads to IVD degeneration, which is associated with debilitating back pain. Successful healing of connective tissue injuries relies on temporally regulated immune cells that rapidly infiltrate damaged tissues and initiate regenerative cascades. These immune cells migrate into injured tissues and function as critical mediators of tissue regeneration and healing. However, the identity of these immune cell subtypes, their temporal coordination, and their effect on the IVD healing response after acute injury remain understudied. The objective of this study is to prevent IVD degeneration by defining the role of infiltrating immune cells during the acute stages of IVD repair. The importance of immune cells in facilitating healing has been well characterized in many musculoskeletal (MSK) tissues, such as bone and muscle, where T lymphocytes have been shown to be critical mediators of repair, but their role in IVD healing is unknown. Preliminary data show an important regulation of Cd3+ T cells in the IVD healing response that varies with sex where 12 week C57BL6 female mice with recurring waves of T cell infiltration during the acute IVD repair stages show less degenerative changes post injury than aged matched males. Therefore, the hypothesis is that Cd3+T cells are essential for IVD healing in female mice. These studies will offer a targeted approach to modulate IVD repair by elucidating the sex-related differences in the types and temporal regulation of key immune cell subtypes important during IVD healing.

Bio:

Dr. Sade Clayton is a Burroughs Wellcome Fund PDEP and Rita Levi- Montalcini Post-Doctoral Fellow in Regenerative Medicine in her third year of her training at Washington University in St. Louis in the Orthopaedic Surgery department. Her PhD thesis work was conducted in the Cell, Developmental and Integrative Biology department at the University of Alabama at Birmingham with Rosa Serra. There, she identified a novel signaling pathway utilized by TGFβ during spinal column formation with an emphasis on spinal fibrous tissue development in mouse and chick embryo models. Her postdoctoral work in the labs of Simon Tang and Lori Setton aims to determine the function of the immune system in the development and repair of the intervertebral discs of the spine using RNA transcriptomics, microscopy, and flow cytometry in mouse and humans.

Zoom:
https://umich.zoom.us/j/99085426766

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Workshop / Seminar Fri, 17 Nov 2023 15:37:24 -0500 2023-11-30T16:30:00-05:00 2023-11-30T17:30:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar A speaker talking to a group of students in a classroom.
Biomedical Engineering Seminar Series (December 7, 2023 4:30pm) https://events.umich.edu/event/115549 115549-21834994@events.umich.edu Event Begins: Thursday, December 7, 2023 4:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Abstract:
Macrophages are innate immune cells that fight infections, repair tissues, and contribute to maintaining tissue homeostasis. Macrophages exhibit extensive cell-to-cell heterogeneity, and my lab is interested in how functional responses emerge from this complexity. I will discuss how my lab has combined single-cell measurements with computational analyses to explore how macrophage interactions via paracrine signaling regulate the collective inflammatory response in vitro. I will also discuss our efforts to resolve macrophage heterogeneity in the more complex environment of melanoma tumors and how this impacts response to combinatorial immunotherapy.

Bio:
Dr. Kathryn Miller-Jensen is an Associate Professor of Biomedical Engineering and Molecular, Cellular, and Developmental Biology at Yale University. Her lab combines experimental and computational approaches to study signaling and transcriptional regulation in the immune system, with a focus on how intercellular heterogeneity drives disease phenotypes. Recent work in the lab explores the regulation of functional heterogeneity in macrophages in inflammation, and how macrophage-mediated extracellular signaling networks shape the tumor microenvironment. Her research is supported by the National Institutes of Health, the National Science Foundation, and the Cancer Research Institute. Prof. Miller-Jensen is an NSF CAREER Award recipient and a fellow of the American Institute of Medical and Biological Engineers. She was an NIH NSRA Postdoctoral Fellow at the University of California at Berkeley and she holds a Ph.D. in Chemical Engineering from the Massachusetts Institute of Technology.

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Workshop / Seminar Tue, 28 Nov 2023 08:25:58 -0500 2023-12-07T16:30:00-05:00 2023-12-07T17:30:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar A speaker talking to a group of students in a classroom.
Biomedical Engineering Seminar Series (January 11, 2024 3:30pm) https://events.umich.edu/event/116591 116591-21837606@events.umich.edu Event Begins: Thursday, January 11, 2024 3:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Abstract:
Imaging deep inside living organisms with cellular resolution remains challenging as recurrent scattering by submicron-scale heterogeneous structures degrades the image-bearing capability of light. In this talk, I will present my work on imaging through turbid tissues with improved resolution and sensitivity using interferometric techniques and computational algorithms. I will first discuss how quantitative phase imaging (QPI) improves contrast and sensitivity in three-dimensional cellular structures. I will show how the phase information provided by QPI is used to retrieve the intrinsic properties of biological samples. Then, I will present a label-free imaging method using deep learning to achieve confocal-level resolution, sensitivity, and chemical specificity non-destructively on unlabeled specimens. Next, I will present an ongoing project on confocal gradient light interference microscopy for in vivo mouse brain imaging with a comparison to multiphoton imaging. The talk will conclude with a discussion of my future research direction on pushing the limits of label-free optical imaging in deep living systems and artificial intelligence-assisted applications.

Bio:
Dr. Xi Chen is a postdoctoral associate and K99/R00 awardee at Cornell University in Prof. Chris Xu’s group. She previously had postdoctoral training at the University of Illinois at Urbana Champaign (UIUC) in Prof. Gabriel Popescu’s Quantitative Light Imaging lab. She received her Ph.D. in Physics in 2019 under the supervision of Prof. Olga Korotkova at the University of Miami. Her research experiences include developing label-free imaging modalities, computational algorithms for studying two-dimensional and three-dimensional cellular structures and clusters, and adaptive optics for multiphoton microscopy. She has 15 peer-reviewed publications, 10 of which are first-author papers in journals including Nature Photonics, Advances in Optics and Photonics, and Light: Science & Applications. She currently works on confocal phase imaging in deep turbid tissues and wavefront sensing and correction for improving multiphoton imaging in live animals funded by her NIH k99/R00 award.

Zoom:
https://umich.zoom.us/j/94801149707

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Workshop / Seminar Fri, 05 Jan 2024 08:46:40 -0500 2024-01-11T15:30:00-05:00 2024-01-11T16:30:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar A speaker talking to a group of students in a classroom.
Biomedical Engineering Seminar Series (January 25, 2024 3:30pm) https://events.umich.edu/event/117192 117192-21838807@events.umich.edu Event Begins: Thursday, January 25, 2024 3:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Abstract:
Over the past two decades, ultrafast ultrasound has rapidly transformed the landscape of diagnostic and preclinical ultrasound imaging. Owing to the ultra-high imaging speed ranging from 1,000 to 10,000 frames per second, ultrafast ultrasound enables the visualization and measurement of many fast and transient physiological phenomena that are intricately linked to the structural and functional properties of biological tissues. In this presentation, I will introduce the principles of ultrafast ultrasound and our recent advancements across various domains such as shear wave elastography, ultrafast Doppler imaging, super-resolution microvascular imaging, functional brain imaging, deep learning, and ultrafast 3D imaging. In addition to the technical development, I will also present preclinical and clinical applications of ultrafast ultrasound in the areas of early detection and characterization of cancer and Alzheimer’s Disease.

Bio:
Pengfei Song, Ph.D. is a Y. T. Lo Faculty Fellow and Assistant Professor of the Department of Electrical and Computer Engineering at the University of Illinois Urbana-Champaign (UIUC). Dr. Song is also an affiliate faculty member with the Beckman Institute for Advanced Science and Technology, Department of Bioengineering, Neuroscience Program, Cancer Center at Illinois, Carl R. Woese Institute for Genomic Biology, and Carle Illinois College of Medicine at UIUC.

Before joining Illinois as a tenure-track assistant professor in 2019, Dr. Song obtained his Ph.D. degree in 2014 and conducted his postdoctoral training under the supervision of Drs. James Greenleaf and Shigao Chen at Mayo Clinic until 2018. His research interests include ultrafast ultrasound imaging, super-resolution ultrasound, functional ultrasound, 3D ultrasound imaging, deep learning, and ultrasound shear wave elastography. Dr. Song has published over 85 peer-reviewed journal papers with a Google Scholar total citation exceeding 4900 and an h-index of 38. He holds several patents that have been licensed and commercialized by major ultrasound companies and used worldwide in the clinic.

Dr. Song has delivered over 20 invited presentations including twice at the Gordon Research Conference. He has been regularly selected to the List of Teachers Ranked as Excellent by Their Students for his teaching career at UIUC.

Dr. Song is a recipient of the NIH K99/R00 Pathway to Independence Award, the NSF CAREER Award, the NIBIB Trailblazer Award, the IEEE Ultrasonics Early Career Investigator Award, and the Chan Zuckerberg Initiative (CZ) Early Career Acceleration Award. His research program has been continuously funded by NIH, DOD CDMRP, and NSF. He is an elected Fellow of the American Institute of Ultrasound in Medicine (AIUM), a Senior Member of the National Academy of Inventors (NAI), a Senior Member of IEEE, and a Full Member of the Acoustical Society of America (ASA).

Zoom:
https://umich.zoom.us/j/94801149707

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Workshop / Seminar Tue, 16 Jan 2024 09:20:34 -0500 2024-01-25T15:30:00-05:00 2024-01-25T16:30:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar A speaker talking to a group of students in a classroom.
Biomedical Engineering Seminar Series (February 8, 2024 3:30pm) https://events.umich.edu/event/118031 118031-21840375@events.umich.edu Event Begins: Thursday, February 8, 2024 3:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

From Seaside to Bedside: Bioengineering Proteins as Tools for Molecular Imaging

Abstract:
Medical imaging has transformed the clinical decision-making process by providing physicians with vital information through MRI, CT, and ultrasound scans. However, despite the benefits of these imaging modalities, there is a critical need to develop new and improved technologies that can monitor changes and abnormalities at the cellular, molecular, and functional levels. Our research lab is at the forefront of the discipline of Molecular Imaging, which is a promising field positioned in the intersection of biomedical research and molecular biology. We focus on creating, implementing, and developing cutting-edge protein engineering techniques to produce genetically encoded tools for Molecular Imaging. In this presentation, we will discuss our latest research findings and their contribution to Molecular Imaging.

We will discuss the development of synthetic and semi-synthetic proteins that can generate contrast through Chemical Exchange Saturation Transfer (CEST)-MRI. We have recently developed new types of proteins that can be efficiently detected through MRI. To achieve this, we designed a novel machine-learning algorithm based on genetic programming, that has allowed us to broaden the search space of peptides that can produce CEST MRI contrast. We have then assembled these peptides into a functional protein that can be used as a reporter to track therapeutic cells and gene delivery vehicles in live systems. We are constantly expanding our arsenal of such reporters by seeking and recombining proteins from various organisms. For example, we are evolving proteins and peptides that bind the lanthanide gadolinium to enhance imaging sensitivity as well as for cleaning medical waste. Another example discussed is a magneto-receptive gene cloned from the glass catfish (Kryptopterus vitreolus). This gene can function as a "biomagnetic switch" and can remotely control the activity of enzymes transduced in cells. Inspired by unique mechanisms found in marine organisms, we aim to develop the next generation of genetically encoded technologies to tackle urgent problems in the biomedical field.

Bio:
Assaf A. Gilad is a Michigan State University Chemical Engineering and Materials Science and Radiology Professor. The overarching theme of his research program is to utilize synthetic biology to develop new biomedical imaging technologies. Specifically, he works to develop novel genetically encoded and nanoparticle biosensors for brain imaging, neuromodulation, and cancer research. He received a B.A. from the Technion, Israel Institute of Technology in Haifa, Israel, and an M.Sc. and Ph.D. in Biology from the Weizmann Institute of Science. He spent three years conducting postdoctoral research in the Department of Radiology at The Johns Hopkins University. In 2007, he joined the Radiology department at The Johns Hopkins University as an Assistant Professor and later as an Associate Professor. In 2017, he moved to Michigan State University.

Zoom:
https://umich.zoom.us/j/94801149707

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Workshop / Seminar Mon, 29 Jan 2024 14:42:18 -0500 2024-02-08T15:30:00-05:00 2024-02-08T16:30:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar A speaker talking to a group of students in a classroom.
Biomedical Engineering Seminar Series (February 15, 2024 3:30pm) https://events.umich.edu/event/118620 118620-21841299@events.umich.edu Event Begins: Thursday, February 15, 2024 3:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Abstract:
The microbiome represents an exciting frontier in medicine, and early successes in the field have demonstrated the dynamic interactions among individual microbial species and highlighted the crosstalk between microbiota and their hosts at the mucosal interface. In this talk, I will present our work from the past few years in interrogating and manipulating commensal bacteria and probiotics as therapeutic platforms to promote human health.

Bio:
Dr. Li earned his PhD in Biomedical Engineering at Cornell University in 2015, where he leveraged synthetic biology approaches and cell biology to engineer bacteria and platelets as platforms to address cancer. Later, he performed postdoctoral training at MIT (2015-2018), where he gained new training in RNA chemistry and delivery. He was a tenure-track Assistant Professor in the Department of Bioengineering at Northeastern University from 2019 to 2023.

Dr. Li relocated the lab to the University of Michigan in the summer of 2023, and his research focuses on the development of molecular and live cell-based therapeutics to interrogate and manipulate interactions among therapeutics, the microbiome, and host.

Zoom:
https://umich.zoom.us/j/94801149707

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Workshop / Seminar Thu, 08 Feb 2024 14:54:18 -0500 2024-02-15T15:30:00-05:00 2024-02-15T16:30:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar A speaker talking to a group of students in a classroom.
Biomedical Engineering Seminar Series (February 22, 2024 3:30pm) https://events.umich.edu/event/118966 118966-21841970@events.umich.edu Event Begins: Thursday, February 22, 2024 3:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Abstract:
Therapeutic monoclonal antibodies and their derivatives have become the fastest growing drug class and are often thought of as the ideal means of testing the translational significance of newly identified disease mediators. Nonetheless, there are significant barriers to their distribution throughout the body and consequences of relying on non-specific mechanisms of organ uptake. In this talk, I will discuss how affinity can be used to control the accumulation and retention of antibodies and other biotherapeutics at intended sites of action, improving both therapeutic efficacy and translational prospects. Specific examples will include delivery to brain, bone, blood cells, and lung.

Bio:
Dr. Greineder is a practicing emergency physician who earned his MD at the Yale School of Medicine and PhD at the University of Pennsylvania. He did post-doctoral training at the Institute for Translational Medicine and Therapeutics and then moved to the University of Michigan in 2018 to join the Departments of Emergency Medicine and Pharmacology. His lab is part of the BioInterfaces Institute and, largely through collaboration with engineers, pharmaceutical scientists, and disease experts, has developed a number of patented technologies around biotherapeutic delivery.

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Workshop / Seminar Fri, 16 Feb 2024 14:57:46 -0500 2024-02-22T15:30:00-05:00 2024-02-22T16:30:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar A speaker talking to a group of students in a classroom.
Biomedical Engineering Seminar Series (March 7, 2024 3:30pm) https://events.umich.edu/event/119421 119421-21842743@events.umich.edu Event Begins: Thursday, March 7, 2024 3:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Abstract:
I will tell two stories from my lab. The first story is how biophysical cues dictate the formation and maintenance of dense connective tissues. This work includes how muscle loading during embryogenesis dictates the growth of tissues in the knee joint and how cell contractility regulates cell fate and tissue homeostasis. The second story, which started with a serendipitous discovery during my graduate studies, is focused on how the hedgehog signaling pathway is a master regulator of fibrocartilage formation during enthesis development and tendon-to-bone repair in adults.

Bio:
I obtained my undergraduate degree in Materials Science and Engineering with a specialization in Biomaterials from the University of Illinois at Urbana-Champaign in 2005. I completed my PhD in the Functional Tissue Engineering laboratory under the direction of Dr. David Butler at the University of Cincinnati in 2011. After postdoctoral training in musculoskeletal biology with Dr. David Rowe at UConn Health, I moved to the University of Pennsylvania in 2017, where I developed an independent research program in the McKay Orthopaedic Research Laboratory.

My lab’s primary research goals are directed towards understanding the genetic, cellular, and mechanical mechanisms that regulate normal development, disease, and repair of joint tissues. I am particularly interested in identifying markers that define resident progenitors vs. mature cell types and the environmental cues (molecular and mechanical) that regulate their differentiation. I was awarded a K99/R00 grant in 2015 to define the tendon cell lineage and pathways that regulate tenogenesis, which led to our current work investigating the role of hedgehog signaling in tendon-to-bone repair and developing novel drug delivery systems targeting this pathway to improve repair outcomes. My lab also examines how mechanical forces impact the formation and maintenance of dense connective tissues, which have resulted in a recent publication in PNAS and the formation of the Penn Achilles Tendinopathy Center of Research Translation (PAT-CORT). In 2024, I was awarded the Kappa Delta Young Investigator Award from the AAOS for this work. Ultimately, the long-term goals of my lab are directed towards translating these mechanistic studies to novel therapeutic strategies.

Zoom:
https://umich.zoom.us/j/94801149707

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Workshop / Seminar Wed, 28 Feb 2024 08:49:20 -0500 2024-03-07T15:30:00-05:00 2024-03-07T16:30:00-05:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar A speaker talking to a group of students in a classroom.
Biomedical Engineering Seminar Series (March 14, 2024 3:30pm) https://events.umich.edu/event/119836 119836-21843652@events.umich.edu Event Begins: Thursday, March 14, 2024 3:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Abstract:
The global incidence of dementia is increasing, with over 9.9 million new cases each year, translating to a new diagnosis every 3.2 seconds. This upward trend is expected to intensify due to the growing aging population worldwide. Research into modeling dementia encounters unique challenges, including sparse data and complex non-linear interactions between variables and outcomes. In this talk, I will share my recent work on employing artificial intelligence to unravel the mechanisms behind aging and dementia. This work leverages combined insights from data analysis and domain knowledge. Specifically, for imaging-based analysis, we have developed a novel "subspace network" approach. This technique employs efficient deep learning models for non-linear multi-task learning, even with limited data. The subspace network incrementally refines predictions by sketching a low-dimensional subspace that facilitates knowledge transfer across tasks. Our empirical findings show that this method efficiently identifies the correct parameter subspaces and surpasses existing models in predicting clinical scores of dementia from brain imaging data. Additionally, we explore the use of language markers in diagnosing dementia early. We introduce a novel reinforcement learning framework for training a dialogue agent that efficiently interacts with elderly individuals to detect signs of dementia. This agent optimizes conversations by generating a disease-specific lexical probability distribution, aiming to increase diagnostic precision while minimizing the number of conversational turns needed. We have also developed a cross-modality learning framework that synergizes language markers with brain imaging data. By using a contrastive loss technique, this framework aligns linguistic and imaging data, enhancing the predictive accuracy of language-based markers with the help of auxiliary imaging variables derived from language.

Bio:
Jiayu Zhou is an Associate Professor in the Department of Computer Science and Engineering at Michigan State University. He received his Ph.D. degree in computer science from Arizona State University in 2014. He has a broad research interest in large-scale machine learning and data mining, and biomedical informatics. He served as a technical program committee member of premier conferences such as NIPS, ICML, and SIGKDD.

Dr. Zhou's research is supported by the National Science Foundation, the National Institutes of Health, and the Office of Naval Research. He is a recipient of the National Science Foundation CAREER Award (2018). His papers received the Best Student Paper Award at the 2014 IEEE International Conference on Data Mining (ICDM), the Best Student Paper Award at the 2016 International Symposium on Biomedical Imaging (ISBI), the Best Paper Award at the 2016 IEEE International Conference on Big Data (BigData), and Best Paper Award in Health Track, the 2022 SIGKDD Conference on Knowledge Discovery and Data Mining. He was one of the final winners of the NSF/NIST Privacy-Enhancing Technologies Challenges, where his privacy-preserving machine learning innovation was showcased at the Summit of Democracy as a testament to reinforcing democratic values.

Zoom:
https://umich.zoom.us/j/94801149707

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Workshop / Seminar Thu, 07 Mar 2024 09:04:30 -0500 2024-03-14T15:30:00-04:00 2024-03-14T16:30:00-04:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar A speaker talking to a group of students in a classroom.
Biomedical Engineering Seminar Series (March 21, 2024 3:30pm) https://events.umich.edu/event/120097 120097-21844051@events.umich.edu Event Begins: Thursday, March 21, 2024 3:30pm
Location: Electrical Engineering and Computer Science Building
Organized By: Biomedical Engineering

Deep Analysis of Biomedical Image and Omics Data

Abstract:
AI-driven by deep learning is transforming biomedical science and technology. The enormous success of deep learning stems from its unique capability of extracting essential features from big biomedical datasets for decision-making. In this talk, Dr. Islam will first give a broad overview of his works on AI-driven medical image analysis. He will then present his recent work on efficiently analyzing the deep-learning feature space for better interpretability of AI and using the feature space information for designing high-performance AI models for medical image analysis and radiation treatment planning. Dr. Islam is also going to discuss how to convert omics data into images and integrate the omics data and medical images in a single deep-learning workflow.

Bio:
Dr. Md Tauhidul Islam is a Research Scientist at the Laboratory of Artificial Intelligence in Medicine and Biomedical Physics at the Department of Radiation Oncology, Stanford University. He received his Ph.D. from the Department of Electrical and Computer Engineering, at Texas A&M University. In his PhD, Dr. Islam focused on developing novel ultrasound imaging techniques and medical image analysis methods for better diagnosis, prognosis, and treatment of various cancers. His research spans a broad range of topics, including artificial intelligence, medical image analysis, imaging and cancer physics, big omics data analytics, and image-guided interventions. He has published 41 journal articles and 11 conference papers. Dr. Islam has been awarded an NIH K99/R00 (Pathway to Independence) award.

Zoom:
https://umich.zoom.us/j/94801149707

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Workshop / Seminar Wed, 13 Mar 2024 00:10:41 -0400 2024-03-21T15:30:00-04:00 2024-03-21T16:30:00-04:00 Electrical Engineering and Computer Science Building Biomedical Engineering Workshop / Seminar A speaker talking to a group of students in a classroom.