{ "143395-21893072": { "datetime_modified":"20260107T120530", "datetime_start":"20260914T110000", "datetime_end":"20260914T120000", "has_end_time":1, "date_start":"2026-09-14", "date_end":"2026-09-14", "time_start":"11:00:00", "time_end":"12:00:00", "time_zone":"America\/Detroit", "event_title":"Human Genetics Research Seminar Series", "occurrence_title":"", "combined_title":"Human Genetics Research Seminar Series: presenting Yang Shi, PhD Professor of Epigenetics Ludwig Institute for Cancer Research, Oxford University, Oxford, England", "event_subtitle":"presenting Yang Shi, PhD Professor of Epigenetics Ludwig Institute for Cancer Research, Oxford University, Oxford, England", "event_type":"Lecture \/ Discussion", "event_type_id":"13", "description":"Monday, September 14, 2026\r\n11:00am - 12:00pm\r\nLocation TBD\r\n\r\nYang Shi, PhD\r\nProfessor of Epigenetics\r\nLudwig Institute for Cancer Research\r\nOxford University, Oxford, England\r\n\u201cSeminar Title TBD\u201d\r\n\r\nHosted By: Shigeki Iwase, PhD, Department of Human Genetics\r\n___\r\nBefore joining Ludwig Oxford in 2020, I was Professor of Cell Biology and C. H. Waddington Professor of Pediatrics at Harvard Medical School. I received my PhD from New York University and postdoctoral training at Princeton University. I joined Harvard Medical School as an Assistant Professor in 1991 and was appointed a Professor of Pathology in 2004. In 2009 I joined the Newborn Medicine Division of Boston Children\u2019s Hospital.\r\n\r\nI am interested in identifying key epigenetic regulators in cancer, elucidating their mechanism of action and providing the conceptual basis for translating our basic findings to the clinic via the development of new therapeutic strategies. With the discovery of the first histone methyl eraser, LSD1, in 2004, our group demonstrated that histone methylation is dynamically regulated, which overturned the long-held dogma that such modifications were static and irreversible. We have also discovered many additional histone demethylases with different specificities, and novel readers, including those that specifically recognize unmodified lysine and arginine and suggest that the unmodified states are not simply a ground neutral state of epigenetic information but rather likely code for epigenetic information as modified states. Importantly, many of these chromatin enzymes and readers have since been implicated in various types of human cancers, indicating an important role of chromatin regulation in tumorigenesis.\r\n\r\nMore recently, we have also been studying RNA modifications and how they impact gene expression regulation. In many ways this exciting field parallels the early days of chromatin biochemistry and biology, i.e., the nature and the biological and pathological functions of RNA modifications, as well as the enzymes responsible for writing, erasing and reading them, are just beginning to be understood.\r\n\r\nAt Ludwig Oxford, my lab is focusing on two questions. First, how to convert \u201ccold tumors to \u201chot\u201d and how to sustain durable responses to cancer immune checkpoint blockade therapy. Second, how to induce therapeutic differentiation of cancers, using acute myeloid leukemia and diffuse intrinsic pontine glioma as models where chromatin\/epigenetics have been shown to play a crucial role in the maintenance of a poorly differentiated state.", "occurrence_notes":null, "guid":"143395-21893072@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/143395", "building_id":"", "building_name":"", "campus_maps_id":"", "room":"", "location_name":null, "has_livestream":0, "cost":"", "tags":["Natural Sciences","genomics","human genetics","Human Genetics, Genetics, Epidemiology","Human Genetics, Genetics, Neurogenetic Diseases","Information and Technology","lecture","Life Science","lifton","Medicine","genome","neel","neurological disease","Postdoctoral Research Fellows","Public Health","Public Policy","Reception","research","Science","seminar","genetics","symposium","sodium channel","Basic Science","basic sciences","biolgical chemistry","biological chemistry","biological science","Biology","Biosciences","Bsbsigns","cancer","Chemistry","Discussion","epilepsy","Faculty","Free"], "website":"https:\/\/medschool.umich.edu\/events?f%5B0%5D=series%3A13266", "sponsors":[ { "group_name":"Department of Human Genetics", "group_id":"1137", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21893072 } , "145914-21898092": { "datetime_modified":"20260226T144516", "datetime_start":"20260915T200000", "datetime_end":"", "has_end_time":0, "date_start":"2026-09-15", "date_end":"", "time_start":"20:00:00", "time_end":"", "time_zone":"America\/Detroit", "event_title":"Bill Edwards Album Release and Birthday Celebration", "occurrence_title":"", "combined_title":"Bill Edwards Album Release and Birthday Celebration: Feat. Grant Flick, Jason Dennie, and John Holkeboer w\/sg Kathy Wieland", "event_subtitle":"Feat. Grant Flick, Jason Dennie, and John Holkeboer w\/sg Kathy Wieland", "event_type":"Performance", "event_type_id":"15", "description":"Bill Edwards is an award-winning singer\/songwriter from Ann Arbor, MI. He\u2019s known for his thoughtful, moving and sometimes hilarious songs, supported by his fine voice and excellent guitar playing. You\u2019d probably call his style \u201crootsy\u201d, ranging from classic country to acoustic rock, with an emphasis on well-crafted lyrics.", "occurrence_notes":null, "guid":"145914-21898092@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/145914", "building_id":"", "building_name":"", "campus_maps_id":"", "room":"", "location_name":"ARK Reserved", "has_livestream":0, "cost":"See Site For Pricing Information", "tags":["Ark","Mutotix"], "website":"https:\/\/www.kathywieland.com\/", "sponsors":[ { "group_name":"Michigan Union Ticket Office (MUTO)", "group_id":"1053", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2026\/02\/event_145914_original-1.jpg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2026\/02\/event_145914_original-1.jpg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2026\/02\/event_145914_original-1.jpg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2026\/02\/event_145914_original-1.jpg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2026\/02\/event_145914_original-1.jpg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2026\/02\/event_145914_original-1.jpg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2026\/02\/event_145914_original-1.jpg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2026\/02\/event_145914_original-1.jpg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2026\/02\/event_145914_original-1.jpg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2026\/02\/event_145914_original-1.jpg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2026\/02\/event_145914_original-1.jpg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2026\/02\/event_145914_original-1.jpg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2026\/02\/event_145914_original-1.jpg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2026\/02\/event_145914_original-1.jpg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2026\/02\/event_145914_original-1.jpg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2026\/02\/event_145914_original-1.jpg" }, "occurrence_count":1, "first_occurrence":21898092 } , "139459-21885567": { "datetime_modified":"20250918T100906", "datetime_start":"20260916T200000", "datetime_end":"", "has_end_time":0, "date_start":"2026-09-16", "date_end":"", "time_start":"20:00:00", "time_end":"", "time_zone":"America\/Detroit", "event_title":"The Gothard Sisters", "occurrence_title":"", "combined_title":"The Gothard Sisters: Presented by The Ark", "event_subtitle":"Presented by The Ark", "event_type":"Performance", "event_type_id":"15", "description":"The Gothard Sisters are three sisters Greta, Willow and Solana. They are contemporary Celtic folk multi-instrumentalists, composers, performers and songwriters. Blending Celtic, folk, world, classical and new age musical influences, the Gothard Sisters bring songs to life with violin, acoustic guitar, mandolin, bodhran, djembe, whistle and vocal harmonies, creating music that is \u201cvivid, inspirational and captivating.\u201d (Tim Carroll, Folk Words Review 2018)\r\n\r\nRaised and homeschooled by artists in the Pacific Northwest, the Gothard Sisters grew up immersed in nature, imaginative play and traditional folk and classical music. Their music takes inspiration from folk music traditions around the world, timeless stories, new age and classical records, and nature itself. Writing and recording near their home in the Pacific Northwest, USA, the band has released 11 albums and performed over 2,000 live shows over the course of their career.", "occurrence_notes":null, "guid":"139459-21885567@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/139459", "building_id":"", "building_name":"", "campus_maps_id":"", "room":"", "location_name":"ARK Reserved", "has_livestream":0, "cost":"See Site For Pricing Information", "tags":["Mutotix","Ark"], "website":"https:\/\/theark.org\/support-the-ark\/", "sponsors":[ { "group_name":"Michigan Union Ticket Office (MUTO)", "group_id":"1053", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2025\/09\/event_139459_original-2.jpg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2025\/09\/event_139459_original-2.jpg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2025\/09\/event_139459_original-2.jpg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2025\/09\/event_139459_original-2.jpg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2025\/09\/event_139459_original-2.jpg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2025\/09\/event_139459_original-2.jpg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2025\/09\/event_139459_original-2.jpg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2025\/09\/event_139459_original-2.jpg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2025\/09\/event_139459_original-2.jpg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2025\/09\/event_139459_original-2.jpg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2025\/09\/event_139459_original-2.jpg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2025\/09\/event_139459_original-2.jpg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2025\/09\/event_139459_original-2.jpg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2025\/09\/event_139459_original-2.jpg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2025\/09\/event_139459_original-2.jpg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2025\/09\/event_139459_original-2.jpg" }, "occurrence_count":1, "first_occurrence":21885567 } , "143758-21893965": { "datetime_modified":"20260318T093432", "datetime_start":"20260918T120000", "datetime_end":"20260918T123000", "has_end_time":1, "date_start":"2026-09-18", "date_end":"2026-09-18", "time_start":"12:00:00", "time_end":"12:30:00", "time_zone":"America\/Detroit", "event_title":"Heartfulness Meditation", "occurrence_title":"", "combined_title":"Heartfulness Meditation: Pushyami Gundala", "event_subtitle":"Pushyami Gundala", "event_type":"Well-being", "event_type_id":"12", "description":"Heartfulness Guided Meditation is a weekly, drop-in program designed to help you Mental well-being. \r\n\r\nAll U-M students, faculty, and staff are welcome to participate in guided meditation practice with a trainer every Friday at noon over Zoom (details to join are provided below). No prior experience with meditation is required. \r\n\r\n*What will you learn?*\r\n\r\nThe guided meditation practice involves three simple steps: relaxation, rejuvenation, and meditation.\r\n\r\nRelaxation brings your body to a calm, steady posture creating a stillness at the physical level, and prepares the mind for meditation. We follow this with a rejuvenation method to detox the mind to let go of stress and complex emotions, and will leave you feeling light and refreshed. Lastly, learning to meditate by being mindful of your heart will connect you with yourself by listening to your heart\u2019s voice. \r\n\r\n*Why Meditate?*\r\n\r\nWhile physical fitness keeps our bodies in shape, meditation is an exercise for the mind and mental wellness. In addition to the measurable benefits mentally and physically, many people benefit from an unquantifiable inner poise and harmony. \r\n\r\n*Please take Learn to Meditate session if you are new to the practice. These sessions are offered Monthly.* https:\/\/events.umich.edu\/event\/128708\r\n\r\n*Event Details*\r\n\r\nHeartfulness Guided Meditation \r\nFridays from 12-12:30 p.m. ET (except during university season days \/ holidays)\r\nJoin Via Zoom Meeting\r\nRegister to receive Passcode (see \u201cRelated links\u201d\r\n\r\n\r\nThis wellness program is coordinated by ITS Teaching & Learning and provided at no cost by heartfulness.org.", "occurrence_notes":null, "guid":"143758-21893965@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/143758", "building_id":"null", "building_name":"Off Campus Location", "campus_maps_id":"1", "room":"", "location_name":"Virtual", "has_livestream":1, "livestream_type":"other", "livetream_require_login":0, "livestream_id":"", "livestream_link":"", "cost":"", "tags":["Well-being","Health & Wellness","Free"], "website":"https:\/\/ttc.iss.lsa.umich.edu\/ttc\/sessions\/upcoming\/?s=Heartfulness+Meditation", "sponsors":[ { "group_name":"Information and Technology Services (ITS)", "group_id":"1179", "website":"https:\/\/x.com\/umichTECH" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2026\/01\/event_143758_original-1.png", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2026\/01\/event_143758_original-1.png", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2026\/01\/event_143758_original-1.png", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2026\/01\/event_143758_original-1.png", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2026\/01\/event_143758_original-1.png", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2026\/01\/event_143758_original-1.png", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2026\/01\/event_143758_original-1.png", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2026\/01\/event_143758_original-1.png", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2026\/01\/event_143758_original-1.png", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2026\/01\/event_143758_original-1.png", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2026\/01\/event_143758_original-1.png", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2026\/01\/event_143758_original-1.png", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2026\/01\/event_143758_original-1.png", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2026\/01\/event_143758_original-1.png", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2026\/01\/event_143758_original-1.png", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2026\/01\/event_143758_original-1.png" }, "occurrence_count":52, "first_occurrence":21893930 } }