We provide precise conditions for nonparametric identification of causal effects by high-frequency event study regressions, which have been used widely in the recent macroeconomics, financial eco- nomics and political economy literatures. The high-frequency event study method regresses changes in an outcome variable on a measure of unexpected changes in a policy variable in a narrow time window around an event or a policy announcement (e.g., a 30-minute window around an FOMC an- nouncement). We show that, contrary to popular belief, the narrow size of the window is not sufficient for identification. Rather, the population regression coefficient identifies a causal estimand when (i) the effect of the policy shock on the outcome does not depend on the other variables (separability) and (ii) the surprise component of the news or event dominates all other variables that are present in the event window (relative exogeneity). Technically, the latter condition requires the ratio between the variance of the policy shock and that of the other variables to be infinite in the event window. Under these conditions, we establish the causal meaning of the event study estimand corresponding to the regression coefficient and the consistency and asymptotic normality of the event study estimator. Notably, this standard linear regression estimator is robust to general forms of nonlinearity. We apply our results to Nakamura and Steinsson’s (2018a) analysis of the real economic effects of monetary pol- icy, providing a simple empirical procedure to analyze the extent to which the standard event study estimator adequately estimates causal effects of interest.