My lab has focused on adaptive protein evolution, with a particular focus on the function and evolution of reproductive proteins. The rapid divergence of reproductive proteins could result in speciation due to the mismatch of sperm-egg recognition molecules. Our approach is highly integrative, using proteomics, genomics, biochemical and computational approaches. We work on a variety of taxonomic groups, including abalone, plants, Drosophila and primates. I will demonstrate how the use of proteomics has been invaluable for the study of reproductive protein evolution in these systems. In particular, I will focus on how studies of molecular co-evolution can shed light on the function of reproductive proteins including predicting protein - protein interactions.