I will present aspects of AdS_2 holography for a specific Einstein-Maxwell-Dilaton model that is obtained by Kaluza-Klein reduction from pure AdS_3 gravity with negative cosmological constant. In particular, I will derive the one-dimensional holographic dual for both running and constant dilaton solutions, and I will discuss the connection with the Sachdev-Ye-Kitaev model. Finally, I will explain how this dilaton gravity model provides a holographic description for four-dimensional asymptotically conformally AdS_2 x S^2 non-extremal black holes. The talk is based on the recent paper https://arxiv.org/abs/1608.07018