Methanobactins (Mbns) are ribosomally synthesized, post-translationally modified peptide natural products that were first isolated from methane-oxidizing bacteria (methanotrophs). Produced during conditions of copper starvation, secreted Mbns scavenge and bind copper, and are internalized to provide copper for the bacteria. This seminar will focus on efforts to identify and characterize the protein machinery responsible for the trafficking of Mbns in methanotrophs.
Laura Dassama (Northwestern University)