Presented By: Biomedical Engineering
Decoding morphogenic instruction in human microphysiological systems
Biomedical Engineering (BME 500) Seminar Series - Matt Kutys, Ph.D.
Abstract:
Tissue structure and function requires coordination between the physical organization of cells and the genetic programs controlling cell phenotype. Our lab investigates how intersections of chemical and mechanical signals at cell adhesive interfaces function across time and length scales to orchestrate 3D tissue morphogenesis and regulatory signaling. To do so, we develop and apply biomimetic human microphysiological culture systems that incorporate 3D organotypic architectures and permit the study of diverse tissue morphogenic processes associated with human development, regeneration, and pathogenesis with high resolution and biological control. Combining these systems with new molecular tools and microscopy-based methods, we have gained new mechanistic insight into diverse tissue morphogenic events ranging from the genesis and progression of human tuberculosis granulomas to the coordinated assembly and maintenance of human microvascular networks. In this talk, I will highlight these recent advances and detail our recent work establishing a previously unappreciated function for Notch receptors that links adhesive and cytoskeletal processes to transcriptional regulation of cell fate.
Bio:
Matt Kutys is an Assistant Professor in the Department of Cell and Tissue Biology at the University of California San Francisco (UCSF) and is faculty in the Helen Diller Family Comprehensive Cancer Center, the Cardiovascular Research Institute, and the UCSF – UC Berkeley Joint Graduate Program in Bioengineering. Dr. Kutys obtained his BS in Bioengineering from Pennsylvania State University working Dr. William Hancock and he received his PhD in Cell and Developmental Biology from the University of North Carolina Chapel Hill and the National Institutes of Health under Dr. Kenneth Yamada. He was a postdoctoral fellow at Boston University under Dr. Christopher Chen before joining UCSF in 2020. Dr. Kutys is the recipient of an NCI Pathway to Independence Award, a UCSF Program for Breakthrough Biomedical Research Award, and is a Shu Chien Early Career Award Lecturer from the Bioengineering Institute of California.
Zoom:
https://umich.zoom.us/j/91375430500
Tissue structure and function requires coordination between the physical organization of cells and the genetic programs controlling cell phenotype. Our lab investigates how intersections of chemical and mechanical signals at cell adhesive interfaces function across time and length scales to orchestrate 3D tissue morphogenesis and regulatory signaling. To do so, we develop and apply biomimetic human microphysiological culture systems that incorporate 3D organotypic architectures and permit the study of diverse tissue morphogenic processes associated with human development, regeneration, and pathogenesis with high resolution and biological control. Combining these systems with new molecular tools and microscopy-based methods, we have gained new mechanistic insight into diverse tissue morphogenic events ranging from the genesis and progression of human tuberculosis granulomas to the coordinated assembly and maintenance of human microvascular networks. In this talk, I will highlight these recent advances and detail our recent work establishing a previously unappreciated function for Notch receptors that links adhesive and cytoskeletal processes to transcriptional regulation of cell fate.
Bio:
Matt Kutys is an Assistant Professor in the Department of Cell and Tissue Biology at the University of California San Francisco (UCSF) and is faculty in the Helen Diller Family Comprehensive Cancer Center, the Cardiovascular Research Institute, and the UCSF – UC Berkeley Joint Graduate Program in Bioengineering. Dr. Kutys obtained his BS in Bioengineering from Pennsylvania State University working Dr. William Hancock and he received his PhD in Cell and Developmental Biology from the University of North Carolina Chapel Hill and the National Institutes of Health under Dr. Kenneth Yamada. He was a postdoctoral fellow at Boston University under Dr. Christopher Chen before joining UCSF in 2020. Dr. Kutys is the recipient of an NCI Pathway to Independence Award, a UCSF Program for Breakthrough Biomedical Research Award, and is a Shu Chien Early Career Award Lecturer from the Bioengineering Institute of California.
Zoom:
https://umich.zoom.us/j/91375430500
Livestream Information
ZoomOctober 27, 2022 (Thursday) 4:30pm
Meeting ID: 91375430500
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