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Presented By: DCMB Seminar Series

DCMB Seminar - Presenter: Luca Pinello (Assoc. Prof. at MGH and HMS)

Talk title: Computational methods to understand gene regulation and development


CRISPR genome editing technologies and single-cell assays have opened new opportunities to study cellular systems and gene regulation at an unprecedented level of detail.

In this talk, I will first present computational methods we have developed to uncover and dissect regulatory elements using CRISPR genome editing technologies. I will also discuss challenges associated with using CRISPR technologies related to designing perturbations and quantifying editing outcomes.

I will then cover our work in modeling data from current single-cell assays, discussing methods to uncover development trajectories, recover RNA-velocity with uncertainty, and create interpretable regulatory maps from multi-omics data using graph embedding techniques.

Short bio:
Luca Pinello is a computational biologist and leader in developing computational methods for functional genomics, genome editing and single cell technologies. He holds a Ph.D. in Mathematics and Computer Science from University of Palermo, Italy. He is currently an Associate Pathologist at Massachusetts General Hospital (MGH) and an Associate Professor of Pathology at Harvard Medical School. He is also part of the MGH Center for Cancer Research and an Associate Member of the BROAD Institute of MIT and Harvard. He has developed several foundational computational tools in the field of genome editing for the design (CRISPRme, CRISPRitz, PrimeDesign), quantification (CRISPResso 1 and 2), and analyses of coding and non-coding tiling screens (CRISPRO, CRISPR-SURF). He was awarded one of the first NIH R35 Genomic Innovator Awards, a prestigious grant supporting highly innovative researchers working on important problems in genomics.
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