Abstract:
The current surgical treatment of malignant brain tumors is invasive and can lead to bleeding and morbid complications. Histotripsy is a noninvasive cavitational ultrasound surgical method that has shown great promise as a noninvasive neurosurgical technology. This dissertation presents image-guided transcranial histotripsy as a potential neurosurgical modality for brain tumors. The first chapter introduces image guidance, brain tumors, the current standard of care, investigative ablation modalities, the mechanism of transcranial histotripsy, and the potential of transcranial histotripsy as a neurosurgical interventional tool. The second chapter discusses the development of a stereotactic transcranial histotripsy targeting system for in vivo murine brain models, The third chapter investigates the magnetic resonance imaging (MRI) analysis and characterization of in vivo features of transcranial histotripsy on murine models. The fourth chapter discusses the first-pass investigation of the blood-brain barrier (BBB) status following transcranial histotripsy in in vivo mice brains. The fifth chapter presents the system error analysis and feasibility of a neuronavigation-guided transcranial histotripsy (NaviTH) system designed for cadaveric models. The final chapter concludes with future work for murine and cadaveric transcranial histotripsy.

Zoom Link: https://umich.zoom.us/j/91504014959
Meeting ID: 915 0401 4959
Password: 0000

Committee Chair(s):
Dr. Zhen Xu