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Presented By: Biomedical Engineering

Dynamic communication networks between regulatory T cells and mesenchymal stromal cells regulate muscle repair and regeneration

Biomedical Engineering (BME 500) Seminar Series - Andrés Muñoz-Rojas, PhD

BME Seminar Series BME Seminar Series
BME Seminar Series
Abstract:

Tissue repair and regeneration require a temporally coordinated immune response to clear affected areas and rebuild tissue architecture. To study the dynamic regulation of muscle repair, we generated a time-resolved single-cell RNA sequencing dataset of regulatory T cells (Tregs) and mesenchymal stromal cells (MSCs) in a mouse model of skeletal muscle injury. We built a computational tool to predict the dynamic cellular communication networks between these cell types and found distinct communication pathways during different phases of repair. Using a combination of in vivo CRISPR and genetic mouse models, we validated these interactions and identified novel communication pathways that regulate tissue regeneration.



Short Bio:

Dr. Andrés Muñoz-Rojas is originally from Mexico City. He has a degree in Bioengineering from the University of Pennsylvania. Andrés got his PhD in Biomedical Engineering at Yale University, where he worked with Dr. Kathryn Miller-Jensen using single-cell secretion and transcription technologies to study macrophage polarization in vitro and in tumor microenvironments. He then joined the lab of Diane Mathis at Harvard Medical School as a Postdoctoral Fellow to study tissue immunology and explore the role of Tregs in regulating tissue function.
BME Seminar Series BME Seminar Series
BME Seminar Series

Livestream Information

 Zoom
March 23, 2023 (Thursday) 3:30pm
Meeting ID: 91712262512

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