A homeostatic control system for breathing regulation serves to maintain blood gases and tissue acid-base status, with lung ventilation dynamically regulated to maintain CO2/H+ within a narrow physiological range. In this talk, we will describe the identification of a long-sought group of brainstem neurons that are critically responsible for CO2 sensation in the service of breathing control, and of the molecular proton detectors that subserve this sensory function. We will also describe some of the intrinsic properties and neuromodulatory capabilities of these neurons, including our discovery of a peptidergic system that activates at the time of birth to stabilize breathing. Finally, we will provide evidence that this system may contribute to various breathing disorders, including congenital central hypoventilation syndrome (CCHS).

About the Speaker:
Doug Bayliss, Ph.D.
Joseph & Frances Larner Professor and Chair of Pharmacology
University of Virginia, Charlottesville

Doug Bayliss obtained his Ph.D. in Physiology from the University of North Carolina and, after postdoctoral training in Physiology and Biophysics at the University of Washington, he joined the faculty at the University of Virginia where he is currently the Joseph and Frances Larner Professor and Chair of Pharmacology. Dr. Bayliss has a long-standing interest in cellular and ionic mechanisms that regulate brain function, with a particular interest in the receptors, signaling pathways and ion channel effectors that underlie neurotransmitter/neuropeptide modulation of brainstem neurons involved in cardiorespiratory control. Another area of interest is in understanding activation of Pannexin ion channels, which are widely expressed and release ATP and other metabolites for intercellular signaling in multiple (patho)physiological contexts.

Please Note:
This is a Hybrid Seminar: In person at Palmer Commons Forum Hall and on Zoom.