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Presented By: LSA Biophysics

From molecular biophysics to developing high content genomics tools to unlock new therapeutic potential

Katie Geiger-Schuller (Genentech)

My training in molecular biophysics served as a solid platform to explore a variety of new, high-content technologies and data. Moreover, the ability to operate at the interface of mathematical modeling, technology development, and biology created a unique opportunity to ask challenging questions in cross-functional teams.

Specifically, recent advances in single cell biology and human genetics have enabled profiling transcriptomics of healthy and diseased individuals leading to the discoveries of gene programs and genetic variants associated with disease. However, we lack robust pipelines to understand the function of implicated genes and to place those genes in directional cellular and tissue circuits. We are uniquely suited to bring together emerging multimodal single cell technologies and advances in CRISPR screening to map genetic circuits in unprecedented resolution thus opening new questions and unlocking new therapeutic potential.

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