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Presented By: LSA Biophysics

The awesome power of fluorine NMR - from drugs to cells

Angela Gronenborn (University of Pittsburgh)

Nuclear magnetic resonance (NMR) spectroscopy is a versatile tool for probing structure, dynamics, folding, and interactions at atomic resolution. While naturally occurring magnetically active isotopes, such as 1 H, 13 C, or 15 N, are most commonly used in biomolecular NMR, with 15 N and 13 C isotopic labeling routinely employed at the present time, 19 F is a very attractive and sensitive alternative nucleus, which offers rich information on biomolecules in solution and in the solid state. This presentation will summarize the unique benefits of solution, solid-state and in-cell 19 F NMR spectroscopy for the study of biomolecular systems. Particular focus will be placed on the most recent studies and on unique and important potential applications of fluorine NMR methodology.

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