Presented By: Center for RNA Biomedicine
RNA Innovation Seminar: Evgeny Nudler, New York University
Transcription-driven DNA repair
HYBRID SEMINAR:
In-person: BSRB, ABC seminar rooms
Zoom: https://umich.zoom.us/webinar/register/WN_axswG-EGQSaGb6mmEGNlbQ
Abstract: Using E. coli as a model system, we have developed new approaches to study damage recognition and processing in vivo for three major DNA repair pathways, nucleotide excision repair (NER), ribonucleotide excision repair (RER), and base excision repair (BER). Our recent findings let us to formulate a conceptually new model of global transcription-driven repair (TDR), in which RNA polymerase serves as the indispensable genome-wide DNA damage sensor and
also delivery vehicle and platform for the assembly of specialized repair complexes in living cells. The model provides a framework for better understanding genotoxic stress response and genome instability in bacteria and beyond.
Keywords: DNA repair, transcription elongation, RNA polymerase, ppGpp, NER, BER, RER
In-person: BSRB, ABC seminar rooms
Zoom: https://umich.zoom.us/webinar/register/WN_axswG-EGQSaGb6mmEGNlbQ
Abstract: Using E. coli as a model system, we have developed new approaches to study damage recognition and processing in vivo for three major DNA repair pathways, nucleotide excision repair (NER), ribonucleotide excision repair (RER), and base excision repair (BER). Our recent findings let us to formulate a conceptually new model of global transcription-driven repair (TDR), in which RNA polymerase serves as the indispensable genome-wide DNA damage sensor and
also delivery vehicle and platform for the assembly of specialized repair complexes in living cells. The model provides a framework for better understanding genotoxic stress response and genome instability in bacteria and beyond.
Keywords: DNA repair, transcription elongation, RNA polymerase, ppGpp, NER, BER, RER
Co-Sponsored By
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