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Presented By: Center for RNA Biomedicine

RNA Innovation Seminar: Evgeny Nudler, New York University

Transcription-driven DNA repair

Evgeny Nudler Evgeny Nudler
Evgeny Nudler
In-person: BSRB, ABC seminar rooms

Abstract: Using E. coli as a model system, we have developed new approaches to study damage recognition and processing in vivo for three major DNA repair pathways, nucleotide excision repair (NER), ribonucleotide excision repair (RER), and base excision repair (BER). Our recent findings let us to formulate a conceptually new model of global transcription-driven repair (TDR), in which RNA polymerase serves as the indispensable genome-wide DNA damage sensor and
also delivery vehicle and platform for the assembly of specialized repair complexes in living cells. The model provides a framework for better understanding genotoxic stress response and genome instability in bacteria and beyond.

Keywords: DNA repair, transcription elongation, RNA polymerase, ppGpp, NER, BER, RER
Evgeny Nudler Evgeny Nudler
Evgeny Nudler

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